title: Interleukin-1alpha and -1beta promoter polymorphisms in Taiwanese patients with dementia.
abstract: BACKGROUND
  Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1alpha -889 C/T and IL-1beta -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD).
  
  
  METHODS
  AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls (n = 209) were analyzed by means of genotype association method.
  
  
  RESULTS
  No significant difference in the genotype distribution of the analyzed single nucleotide polymorphisms was found between AD or VaD cases and controls. However, the frequency of the IL-1alpha -889 CT genotype was notably lower in VaD patients aged over 70 years than the age-matched controls (9.1 vs. 22.9%, p = 0.036) andtheIL-1alpha -889 CT genotype demonstrated a trend toward decrease in risk of developing VaD (odds ratio: 0.34; 95% confidence interval: 0.12-0.83, p = 0.026). Multivariate analysis revealed that the IL-1beta -511T-carrying genotype slightly strengthens the negative association of the IL-1alpha -889 CT genotype with VaD (odds ratio: 0.26; 95% confidence interval: 0.08-0.79, p = 0.024).
  
  
  CONCLUSIONS
  Our data suggest a protective role of the IL-1alpha -889 CT genotype in VaD susceptibility among Taiwanese aged over 70 years.
authors.affiliation: Department of Life Science, National Taiwan Normal University, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan, ROC.
authors.forename: Hsiu-Kuan
authors.initials: HK
authors.lastname: Wang
authors.forename: Wen-Chuin
authors.initials: WC
authors.lastname: Hsu
authors.forename: Hon-Chung
authors.initials: HC
authors.lastname: Fung
authors.forename: Jun-Cheng
authors.initials: JC
authors.lastname: Lin
authors.forename: Hai-Pei
authors.initials: HP
authors.lastname: Hsu
authors.forename: Yih-Ru
authors.initials: YR
authors.lastname: Wu
authors.forename: Yuying
authors.initials: Y
authors.lastname: Hsu
authors.forename: Fen-Ju
authors.initials: FJ
authors.lastname: Hu
authors.forename: Guey-Jen
authors.initials: GJ
authors.lastname: Lee-Chen
authors.forename: Chiung-Mei
authors.initials: CM
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000276:immunology; D015140:Dementia, Vascular / Q000235:genetics* / Q000276:immunology; D005260:Female; D006580:Genetic Carrier Screening; D005838:Genotype; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012306:Risk; D013624:Taiwan
chemical_list: D053582:Interleukin-1alpha; D053583:Interleukin-1beta