TACE: a new target in epidermal growth factor receptor dependent tumors.
Soluble proteins play vital roles in mediating intercellular communication. Many of these proteins are secreted as freely soluble molecules, but an important class of signaling proteins are first synthesized and presented at the cell surface as transmembrane precursor proteins. Unlike classically secreted proteins, many of these molecules are regulated at an additional level, requiring proteolytic cleavage for activity. This review focuses on a subset of these proteins, which are cleaved by tumor necrosis factor alpha-converting enzyme (TACE)/ADAM17, and on their role in cancer.
Kenny
Paraic A
PA
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS977-225A, University of California, Berkeley, CA 94720, USA. pakenny@lbl.gov
D051722:ADAM Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000072198:ADAM17 Protein; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D066246:ErbB Receptors; D051722:ADAM Proteins; D000072198:ADAM17 Protein; C000606462:ADAM17 protein, human