title: Associations between Cloninger's temperament dimensions and acute tobacco withdrawal.
abstract: This study examined associations between three temperament dimensions measured by the Temperament and Character Inventory-125 [Cloninger, C.R. (1992). The Temperament and Character Inventory-125 (TCI-125; Version 1.)] and tobacco abstinence effects. Smokers (N=203, >/= 15 cigarettes/day) attended two laboratory sessions, one following 12 h of abstinence and the other following ad libitum smoking (order counterbalanced). Participants completed measures of withdrawal symptoms, cigarette urges, and affect. Smokers high in Novelty Seeking reported greater abstinence-induced increases in several nicotine withdrawal symptoms, negative affect, and cigarette craving. Smokers high in Harm Avoidance reported greater abstinence-induced increases in negative affect and urges to smoke to relieve distress. Reward Dependence was not associated with abstinence effects. Novelty Seeking and Harm Avoidance showed independent predictive associations with negative affect and urges, and their associations with abstinence effects persisted when controlling for FTND scores. Smokers with different temperaments display different patterns of acute tobacco withdrawal, and may benefit from treatments matched to their particular abstinence profile.
authors.affiliation: Center for Alcohol and Addiction Studies, Brown University, Box G-S121, Providence, RI 02912, USA. adam_leventhal@brown.edu
authors.forename: Adam M
authors.initials: AM
authors.lastname: Leventhal
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Waters
authors.forename: Susan
authors.initials: S
authors.lastname: Boyd
authors.forename: Eric T
authors.initials: ET
authors.lastname: Moolchan
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Heishman
authors.forename: Caryn
authors.initials: C
authors.lastname: Lerman
authors.forename: Wallace B
authors.initials: WB
authors.lastname: Pickworth
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010554:Personality Disorders / Q000175:diagnosis / Q000378:metabolism / Q000523:psychology*; D010555:Personality Inventory; D011594:Psychometrics / Q000379:methods; D015203:Reproducibility of Results; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects* / Q000523:psychology; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000378:metabolism / Q000523:psychology*; D011795:Surveys and Questionnaires; D013694:Temperament; D014029:Tobacco Use Disorder / Q000523:psychology*