title: Surgery insight: advantages and disadvantages of laparoscopic radical cystectomy to treat invasive bladder cancer.
abstract: Laparoscopic radical cystectomy (LRC) is a challenging technique, but it has been proposed as an alternative to open radical cystectomy (ORC), which is currently the gold standard treatment for muscle-invasive or high-risk superficial bladder cancer. So far, approximately 200 cases treated with LRC have been reported in the peer-reviewed literature, but follow-up has generally been short (all <48 months). A shorter hospital stay and a quicker recovery of the patient seem to be the main advantages of LRC over ORC. Functional outcomes, cancer control obtained, and safety of the technique need to be confirmed by studies with larger cohorts of patients and longer follow-up than those previously reported, but an initial analysis suggests that LRC is not equivalent to ORC. Given that the majority of patients selected for LRC had lower American Society of Anesthesiologists scores and lower pathological stages than those in ORC studies, the proportion of patients with orthotopic neobladders (47%) and the proportion of disease-free patients (80%) seem to be suboptimal and, actually, those might represent the major disadvantages of LRC.
authors.affiliation: Largo Rosanna Benzi 10, National Institute for Cancer Research, Genoa, Italy. paolo.puppo@auro.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Puppo
authors.forename: Carlo
authors.initials: C
authors.lastname: Introini
authors.forename: Angelo
authors.initials: A
authors.lastname: Naselli
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D015653:Cystectomy / Q000379:methods*; D003558:Cystoscopy / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D009367:Neoplasm Staging; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000601:surgery*