Development of a new generation of propofol.
OBJECTIVE
The current advance in development of a new generation of propofol and its clinical implications are reviewed.


RESULTS
All currently available formulations of propofol have side effects related to propofol itself, as well as to the emulsion delivery systems. A search for better and safer propofol continues. Improvement of the emulsion delivery systems is one of approaches, which can be achieved by identifying better inactive components, enhancing stability, and applying new technologies such as nanotechnology. Modification of chemical structure is another approach, particularly with the development of propofol prodrugs.


CONCLUSIONS
There is a continuous need to develop a better and safer propofol. The development of a new propofol should be focused on minimizing the unwanted side effects, while preserving the beneficial profiles. Hopefully, just such a new propofol will be available in the near future for clinical use.
Wang
Haibo
H
Department of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. hwang2@lsuhsc.edu
Cork
Randall
R
Rao
Ashock
A
D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D004492:Edetic Acid / Q000737:chemistry; D004655:Emulsions / Q000737:chemistry; D005990:Glycerol / Q000031:analogs & derivatives / Q000737:chemistry; D036103:Nanotechnology; D010316:Particle Size; D011355:Prodrugs / Q000737:chemistry; D015742:Propofol / Q000009:adverse effects / Q000737:chemistry*
D004655:Emulsions; D011355:Prodrugs; D004492:Edetic Acid; D005990:Glycerol; D015742:Propofol