Effects of sulodexide on hemostatic factors, lipid profile, and inflammation in chronic peritoneal dialysis patients.
Sulodexide, a standardized extractive glycosaminoglycan containing 80% "fast moving" heparin and 20% dermatan sulfate, decreased plasma D-dimer, a marker of intravascular coagulation, and fibrinogen levels in chronic peritoneal dialysis patients. Blood levels of von Willebrand factor, lipid, and high-sensitivity C-reactive protein were not significantly changed. No bleeding episodes were reported. These results suggest that sulodexide was effective in partially reversing the thrombogenic coagulation profile without increasing the risk of bleeding.
Kim
Soon Bae
SB
Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sbkin@amc.seoul.kr
Kim
Su Hee
SH
Lee
Moo Song
MS
Chang
Jai Won
JW
Lee
Sang Koo
SK
Park
Jung Sik
JS
D000925:Anticoagulants / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D011446:Prospective Studies; D016896:Treatment Outcome; D014841:von Willebrand Factor / Q000378:metabolism
D000925:Anticoagulants; D015415:Biomarkers; D006025:Glycosaminoglycans; D008055:Lipids; D014841:von Willebrand Factor; C007858:glucuronyl glucosamine glycan sulfate; D002097:C-Reactive Protein