Transmission of influenza A in families.
We conducted a prospective, nested study using nucleotide sequencing to examine influenza positive respiratory samples in families for genetic homology in the hemagglutinin and neuraminidase genes. Influenza A H3N2 viruses from 3 families had identical, family specific, HA1 nucleotide sequences. Sequences among these families were genetically heterogeneous. A 4th family was distinguished by sequencing of the influenza neuraminidase gene.
Teo
Stephen S S
SS
Centre for Child Health, Barts and the London, Queen Mary's School of Medicine and Dentistry, Queen Mary, University of London, UK. teosss@yahoo.com
Ellis
Joanna S
JS
Aitken
Celia
C
Booy
Robert
R
D000328:Adult; D002675:Child, Preschool; D005190:Family; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics / Q000302:isolation & purification*; D007251:Influenza, Human / Q000635:transmission*; D017720:Molecular Epidemiology; D010802:Phylogeny