Early exposure to yellow fever vaccine during pregnancy.
OBJECTIVE
To investigate the association of Yellow Fever Vaccination (YFV) during pregnancy with the presence of structural defect in exposed babies.


METHODS
An observed/expected frequencies study, before and after the vaccination campaign against YF was designed. 304 babies exposed to YFV during the prenatal period underwent dysmorphological examinations. The expected frequencies of malformations were obtained from a reference population of 10,691 births occurred in the period immediately prior to the vaccination campaign and born in the same region. These frequencies were evaluated using Poisson distribution model.


RESULTS
The major malformation rate found in this study was 3.3% (CI 1.7-6.3%). Minor dysmorphisms, especially naevus, were significantly more frequent (P<0.001) than in the reference population.


CONCLUSIONS
The data here presented provide no indication that immunization with YFV early in pregnancy increases the risk of major malformations. However, the association found between YFV during pregnancy and minor dysmorphisms, especially pigmented naevus, seems to be a bias of evaluation. We suggest, nevertheless, that a reproductive risk hypothesis regarding minor dysmorphisms should be considered in future studies involving YFV.
Cavalcanti
Denise P
DP
Programa de Genética Perinatal, Departamento de Genética Médica, FCM, UNICAMP, Campinas, SP, Brazil. denisepc@unicamp.br
Salomão
Maria Antonieta
MA
Lopez-Camelo
Jorge
J
Pessoto
Mônica A
MA
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced / Q000453:epidemiology; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D004314:Down Syndrome / Q000139:chemically induced / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D008598:Menstruation / Q000502:physiology; D009506:Nevus / Q000139:chemically induced; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control; D011256:Pregnancy Outcome; D015995:Prevalence; D012307:Risk Factors; D015004:Yellow Fever / Q000517:prevention & control; D022341:Yellow Fever Vaccine / Q000009:adverse effects*
D022341:Yellow Fever Vaccine