Regulation of the mpt operon in Listeria innocua by the ManR protein.
The phosphotransferase system regulation domain (PRD)-containing activator, ManR, is required for glucose-controlled transcription of the mannose permease two (mpt) operon in Listeria innocua. His-871 in ManR PRD-II is needed for mpt repression in glucose-free media. His-506 in PRD-I is needed for mpt induction by glucose.
Xue
Junfeng
J
Department of Molecular Biology, University of Wyoming, 1000 E. University Avenue, Dept. 3944, Laramie, WY 82071-3944, USA.
Miller
Kurt W
KW
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D004269:DNA, Bacterial / Q000032:analysis; D015964:Gene Expression Regulation, Bacterial; D005947:Glucose / Q000378:metabolism; D008087:Listeria / Q000201:enzymology*; D008969:Molecular Sequence Data; D009154:Mutation; D009876:Operon; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000235:genetics / Q000378:metabolism*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D015534:Trans-Activators; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; C037992:phosphoenolpyruvate-mannose phosphotransferase; D005947:Glucose