Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential.
Survivin's proposed dual role as an apoptosis inhibitor and a mitotic effector positioned it in the front line of cancer research. Notably, survivin is detected as a cytoplasmic and nuclear protein in cancer patients, which stimulated numerous studies to investigate and to speculate on the functional and prognostic significance of its dynamic localization. Recent evidence shows that the direct interaction of survivin with the nuclear export receptor Crm1 is critically involved in its intracellular localization and cancer-relevant functions. Here, we review our current understanding of the Crm1/survivin interface and discuss its potential prognostic and therapeutic relevance.
Stauber
Roland H
RH
Department of Otorhinolaryngology, Molecular and Cellular Oncology, University of Mainz, Mainz, Germany. stauber@hno.klinik.uni-mainz.de
Mann
Wolf
W
Knauer
Shirley K
SK
D021581:Active Transport, Cell Nucleus; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D028884:Karyopherins / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis*; D008938:Mitosis; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D000077022:Survivin; D000097606:Exportin 1 Protein
D051034:Inhibitor of Apoptosis Proteins; D028884:Karyopherins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D000077022:Survivin; D000097606:Exportin 1 Protein; C107489:BIRC5 protein, human