Inhibition of the IGF-I receptor for treatment of cancer. Kinase inhibitors and monoclonal antibodies as alternative approaches.
Wang
Yan
Y
Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
Ji
Qun-Sheng
QS
Mulvihill
Mark
M
Pachter
Jonathan A
JA
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D017526:Receptor, IGF Type 1 / Q000037:antagonists & inhibitors*
D000911:Antibodies, Monoclonal; D047428:Protein Kinase Inhibitors; D017526:Receptor, IGF Type 1