title: The role of cyclooxygenase-2 in breast cancer: review.
abstract: There is a growing body of evidence that COX-2 expression s a fundamental step in breast cancer pathogenesis acting through prostaglandin-dependent and independent mechanisms. Epidemiological studies suggest that NSAIDs confer a moderate degree of benefit against breast cancer. However further work is required to establish how this enzyme system can be best manipulated for therapeutic benefit.
authors.affiliation: St George's University of London, London, UK.
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Singh-Ranger
authors.forename: Mohamed
authors.initials: M
authors.lastname: Salhab
authors.forename: Kefah
authors.initials: K
authors.lastname: Mokbel
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans
chemical_list: D051546:Cyclooxygenase 2