A perspective on DNA microarrays in pathology research and practice.
DNA microarray technology matured in the mid-1990s, and the past decade has witnessed a tremendous growth in its application. DNA microarrays have provided powerful tools for pathology researchers seeking to describe, classify, and understand human disease. There has also been great expectation that the technology would advance the practice of pathology. This review highlights some of the key contributions of DNA microarrays to experimental pathology, focusing in the area of cancer research. Also discussed are some of the current challenges in translating utility to clinical practice.
Pollack
Jonathan R
JR
Department of Pathology, Stanford University School of Medicine, CCSR-3245A, 269 Campus Dr., Stanford, CA 94305-5176, USA. pollack1@stanford.edu
D001363:Awards and Prizes; D016000:Cluster Analysis; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D010338:Pathology, Clinical / Q000379:methods*