Optimized pH-responsive cyanine fluorochromes for detection of acidic environments.
Modulation of pH-responsive cyanine dye pK(a) values via heteroatom substitution allows for design of fluorescent reporters that are tuned for potential imaging of biologically relevant acidic environments.
Hilderbrand
Scott A
SA
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. Scott_Hilderbrand@hms.harvard.edu
Weissleder
Ralph
R
D000143:Acids / Q000737:chemistry*; D002232:Carbocyanines / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*
D000143:Acids; C478828:BEBO cyanine dye; D002232:Carbocyanines; D005456:Fluorescent Dyes