title: Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis.
abstract: Eight new oxygenated lignans, kadsuphilols A-H (1-8), were isolated from the leaves and stems of Kadsura philippinensis. Four of the isolated lignans (1-4) possess the normal C18-dibenzocyclooctadiene skeleton, while the other four lignans (5-8) are C19-homolignans possessing a substituted cyclohexadienone ring with a spiro-benzofuranoid moiety. The structures of the isolated metabolites were elucidated through spectroscopic analyses, including 2D NMR experiments. Compounds 1 and 4 are the first report of an R-biphenyl configuration with a beta-oxygenated substituent at the C-9 position. The in vitro radical-scavenging activities of these compounds using DPPH were tested and evaluated. Compound 3 exhibited more potent activity than vitamins C and E.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China. ycshen@ntu.edu.tw
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.forename: Ting-Wei
authors.initials: TW
authors.lastname: Lan
authors.forename: Chia-Ching
authors.initials: CC
authors.lastname: Liaw
authors.forename: Shorong-Shii
authors.initials: SS
authors.lastname: Liou
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Ashraf Taha
authors.initials: AT
authors.lastname: Khalil
mesh_terms: D001205:Ascorbic Acid / Q000494:pharmacology; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D017705:Lignans; D010851:Picrates; D014810:Vitamin E; C004931:1,1-diphenyl-2-picrylhydrazyl; D001205:Ascorbic Acid