title: Reductions in drug use among young people living with HIV.
abstract: ZIP models were used to detect reductions in drug abuse among young people living with HIV (YPLH) over 15 months when most young people abstain from use. YPLH (n = 171) aged 16 to 29 years were randomly assigned to an 18 session intervention or a delayed-intervention condition. The ZIP models showed significant reductions in abuse of multiple substances over time in the non-delayed intervention. Previous analyses did not find significant reductions. Intervention efficacy often cannot be detected if there are highly skewed distributions of outcomes, such as drug abuse. ZIP modeling offers an opportunity to more reliably detect behavioral changes.
authors.affiliation: Semel Institute for Neuroscience and Human Behavior and the AIDS Institute, University of California, Los Angeles, California, USA. scomulad@ucla.edu
authors.forename: W Scott
authors.initials: WS
authors.lastname: Comulada
authors.forename: Robert E
authors.initials: RE
authors.lastname: Weiss
authors.forename: William
authors.initials: W
authors.lastname: Cumberland
authors.forename: Mary Jane
authors.initials: MJ
authors.lastname: Rotheram-Borus
mesh_terms: D000293:Adolescent; D000328:Adult; D019090:Case Management; D015928:Cognitive Behavioral Therapy; D003430:Cross-Sectional Studies; D005260:Female; D006679:HIV Seropositivity / Q000453:epidemiology* / Q000523:psychology / Q000635:transmission; D006266:Health Education; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D016012:Poisson Distribution; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000523:psychology / Q000534:rehabilitation; D016896:Treatment Outcome; D014481:United States