title: Endometrial directed biopsy during sonohysterography using the NiGo device: prospective study in women with abnormal uterine bleeding.
abstract: OBJECTIVE
  To determine the accuracy of sonohysterography (SHG), combined with sonography-guided biopsies that are performed by using the NiGo device, in the diagnosis of endometrial pathologies in women with abnormal uterine bleeding (AUB).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Outpatient clinic.
  
  
  METHODS
  One hundred sixteen women with AUB (55 postmenopausal and 61 premenopausal).
  
  
  METHODS
  Patients underwent transvaginal sonography and SHG; when an endometrial condition needing a biopsy was diagnosed, the biopsy was performed both by using the NiGo device (ASL 1, Imperia, Italy) and by using Pipelle.
  
  
  METHODS
  Feasibility of SHG and endometrial biopsy by NiGo.
  
  
  RESULTS
  Sonohysterography was successfully performed by using the NiGo device in 87.4% of the cases (92.6% of premenopausal women and 81.5% of postmenopausal women). Seventy-eight (86.7%) women were judged to require endometrial biopsy; the NiGo device allowed obtaining an adequate biopsy for histological evaluation in 74 cases (94.9%). There was no statistically significant difference in efficacy between the NiGo and Pipelle in providing a specimen that was adequate for histological evaluation. Although no significant difference was observed in the histological diagnosis performed on the specimens obtained by the two techniques, NiGo allowed diagnosis of more focal lesions (simple hyperplasia, endometrial polyps, and myomas).
  
  
  CONCLUSIONS
  The NiGo device allows an adequate biopsy for histological evaluation to be obtained during SHG in an outpatient setting.
authors.affiliation: Department of Women and Children, Division of Obstetrics and Gynecology, Imperia Hospital, Imperia, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Gorlero
authors.forename: Luca
authors.initials: L
authors.lastname: Nicoletti
authors.forename: Davide
authors.initials: D
authors.lastname: Lijoi
authors.forename: Simone
authors.initials: S
authors.lastname: Ferrero
authors.forename: Alberto
authors.initials: A
authors.lastname: Pullè
authors.forename: Nicola
authors.initials: N
authors.lastname: Ragni
mesh_terms: D000368:Aged; D000465:Algorithms; D001706:Biopsy / Q000295:instrumentation*; D004717:Endometrium / Q000000981:diagnostic imaging* / Q000473:pathology; D004867:Equipment Design; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D014463:Ultrasonography; D014591:Uterine Diseases / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014592:Uterine Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology