[Genotypic heterogeneity and geographic diversity of collection strains of Francisella tularensis as determined using the VNTR variability analysis and DNA sequencing].
The analysis of the identification genotypes allowed the strains to be grouped into 61 variants from A to I with the incidence rate 0.002-0.142. The cluster analysis of the identification genotypes allowed the strains to be grouped into 9 clusters with different number of components. Actual existence of genotypic heterogeneity and geographic diversity of the F. tularensis strains was demonstrated in addition to territorial attribution of certain strains. The geoinformation system Tularemia was developed to provide spatioterritorial analysis of distribution of the genotypes of the strains. A specific feature of the geoinformation system is dynamic mode of its operation, which provides the ability of continuous addition of information not only by the expense of available data but also by the expense of creation of new layers. Any new information is automatically added to the geoinformation system, thereby providing both retrospective and operative analysis. The geoinformation system Tularemia should find promising application to the structure of the epidemiological method. The use of the system will bring the epidemiological control of tularemia to a qualitatively higher level.
Vodop'ianov
A S
AS
Mishan'kin
B N
BN
Pavlovich
N V
NV
Pichurina
N L
NL
D005604:Francisella tularensis / Q000235:genetics* / Q000302:isolation & purification; D014644:Genetic Variation; D005838:Genotype; D018598:Minisatellite Repeats / Q000235:genetics*; D010802:Phylogeny; D040641:Quantitative Trait Loci / Q000235:genetics*; D017422:Sequence Analysis, DNA