Hereditary evaluation of multiple developmental abnormalities in the Havanese dog breed.
The Havanese is a toy breed that presents with a wide range of developmental abnormalities. Skeletal defects, particularly osteochondrodysplasia (OCD), are the most frequently observed anomalies. Cataracts, liver shunts, heart murmurs, and missing incisors are also common in this breed. Estimates of heritability and complex segregation analyses were carried out to evaluate modes of transmission for these abnormalities. A moderate heritability was identified and evidence for a single major locus was found. Novel statistical analysis methods were used to identify four traits that co-segregate: cataracts, hepatic abnormalities, OCD, and cardiac abnormalities. A canine-specific microarray was used to identify changes in gene expression in the liver that accompany the aforementioned developmental problems. One hundred and thirteen genes were found to be differentially regulated in the Havanese.
Starr
Alison N
AN
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4467, USA.
Famula
Thomas R
TR
Markward
Nathan J
NJ
Baldwin
Joanne V
JV
Fowler
Karon D
KD
Klumb
Diane E
DE
Simpson
Nancy L
NL
Murphy
Keith E
KE
D000375:Aging / Q000235:genetics; D000818:Animals; D002874:Chromosome Mapping; D000013:Congenital Abnormalities / Q000235:genetics / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D015870:Gene Expression; D020411:Oligonucleotide Array Sequence Analysis; D010641:Phenotype