Dendritic cell homeostasis and trafficking in transplantation.
Hematopoietic cell transplantation and solid organ transplantation are definitive therapies for several otherwise fatal conditions. Post-transplant immune reactions are the major cause of morbidity after transplantation and limit the extended use of these critical therapies. Post-transplant immune complications include graft rejection by the host and injury to the host mediated by the graft. Dendritic cells (DCs), a population of professional antigen-presenting cells, are thought to be crucial in triggering primary immune responses against both the graft and the host. Here, we review studies on DC homeostasis and trafficking after transplantation, and examine the role of the host and graft DC in post-transplant immune responses. We also discuss the therapeutic implications of these studies.
Merad
Miriam
M
Department of Gene and Cell Medicine, Mount Sinai Medical School, 1425 Madison Avenue, New York, NY 10029, USA. Miriam.Merad@mssm.edu
Collin
Matthew
M
Bromberg
Jonathan
J
D000818:Animals; D002465:Cell Movement; D003713:Dendritic Cells / Q000502:physiology*; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation; D006706:Homeostasis; D006801:Humans; D016377:Organ Transplantation; D014184:Transplantation, Homologous