Serum prolidase activity in patients with hypertension and its relation with left ventricular hypertrophy.
OBJECTIVE
The purpose of this study was to determine serum prolidase activity in patients with hypertension and its relation with left ventricular hypertrophy.


METHODS
Serum prolidase activity was measured spectrophotometrically in hypertensive patients with (Group II, n=30) and without left ventricular hypertrophy (Group III, n=30) and in control group (Group I, n=30).


RESULTS
Prolidase activity was significantly lower in Group I than in Groups II and III (44.64+/-6.42 U/L vs. 54.14+/-6.30 U/L and 54.25+/-7.14 U/L, respectively; ANOVA, p<0.001). We revealed significant correlation between prolidase activity and presence and duration of hypertension (both of p<0.05) but not left ventricular mass index. Multivariate analysis shown that prolidase activity was significantly associated with age (beta=0.481, p<0.001) and duration of hypertension (beta=0.396, p<0.001).


CONCLUSIONS
Our data show that serum prolidase activity is associated with the presence hypertension independent of left ventricular hypertrophy.
Demirbag
Recep
R
Department of Cardiology, Medical Faculty, Harran University, Sanliurfa, Turkiye, P.K: 112, Sanliurfa, Turkey. rdemirbag@yahoo.com
Yildiz
Ali
A
Gur
Mustafa
M
Yilmaz
Remzi
R
Elçi
Kevser
K
Aksoy
Nurten
N
D000328:Adult; D016022:Case-Control Studies; D004150:Dipeptidases / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000378:metabolism; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013053:Spectrophotometry
D004150:Dipeptidases; C022449:proline dipeptidase