title: In vivo evaluation of the biocompatibility of a new resin-based obturation system.
abstract: OBJECTIVE
  The aim of this study was to evaluate the in vivo biocompatibility of the new resin-based Epiphany-Resilon root canal filling system after implantation in rat connective tissue.
  
  
  METHODS
  Thirty-six female Wistar albino rats, 9 months old, weighing 200 to 220 g, were used to evaluate the biocompatibility. Four subcutaneous pockets were created in the back of the rats, and each material (Resilon, gutta-percha, a Teflon tube containing Epiphany, and an empty Teflon tube) was implanted into a specific dorsal site. The empty Teflon tubes were used as control. After 1, 4, and 8 weeks, the implants were removed with the surrounding tissues. The inflammatory tissue reactions were graded after a histopathologic examination.
  
  
  RESULTS
  At each time period, there was practically no difference in the reaction of all the implant materials (P > .05). The intensity of the reaction had diminished by the 4-week observation period, and this reduction continued through the 8-week observation period.
  
  
  CONCLUSIONS
  All the tested materials showed an acceptable biocompatibility.
authors.affiliation: Department of Endodontics, Faculty of Dentistry, Baskent University, Bahcelievler, Ankara, Turkey. eonay@baskent.edu.tr
authors.forename: Emel Olga
authors.initials: EO
authors.lastname: Onay
authors.forename: Mete
authors.initials: M
authors.lastname: Ungor
authors.forename: Binnaz Handan
authors.initials: BH
authors.lastname: Ozdemir
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000187:drug effects; D005260:Female; D006171:Gutta-Percha / Q000009:adverse effects; D007249:Inflammation / Q000139:chemically induced*; D008422:Materials Testing / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000009:adverse effects*; D012389:Root Canal Obturation / Q000379:methods*; D013997:Time Factors
chemical_list: D012387:Root Canal Filling Materials; C486893:epiphany sealer; C486892:resilon sealer; D006171:Gutta-Percha