Pasty injectable biodegradable polymers derived from natural acids.
Pasty biodegradable polymers that can be mixed with drugs at room temperature and injected to tissue as neat composition are advantageous as they allow simple preparation and delivery of drugs, particularly for heat sensitive drugs. A series of biodegradable pasty poly (ester-anhydride)s were prepared from alkanedicarboxylic acids and ricinoleic acid and its oligomers by transesterification-repolymerization method. The polymers were characterized by common spectroscopic, chromatography, and thermal methods. Polymers containing 70% ricinoleic acid and 30% linear dicarboxylic acids with 4-10 methylene groups were synthesized. The melting point of these poly (ester-anhydride)s increased as the number of methylenes in the alkanedicarboxylic acid increased. Use of short oligomers of ricinoleic acid instead of ricinoleic acid itself increased the melting point and decreased the softness of the resulting polymers. The polymers released model drugs for a few weeks while being degraded to their fatty acid counterparts. Copolymerization of alkanedicarboxylic acids with ricinoleic acid resulted in pasty biodegradable polymers useful as injectable carriers for drugs.
Krasko
Michal Y
MY
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.|Devid R. Bloom Center for Pharmacy, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.|Alex Grass Center for Synthesis and Drug Design, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.
Domb
Abraham J
AJ
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.|Devid R. Bloom Center for Pharmacy, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.|Alex Grass Center for Synthesis and Drug Design, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.
D000143:Acids / Q000737:chemistry*; D001672:Biocompatible Materials; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D011108:Polymers / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D000143:Acids; D001672:Biocompatible Materials; D011108:Polymers