Low-dose oral methotrexate for the management of childhood Cogan's syndrome: a case report.
Cogan's syndrome is a rare inflammatory disease characterized by nonsyphilitic ocular interstitial keratitis associated with hearing loss and vestibular impairment. Although systemic corticosteroids are usually used as the standard therapy, hearing ability in most cases gradually deteriorates. We, herein, describe a patient with childhood Cogan's syndrome who was treated with low-dose oral methotrexate, which successfully helped to taper the doses of the systemic corticosteroids. The serum levels of the complements were good markers for the disease activity in this patient.
Inoue
Yuzaburo
Y
Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan. yuzaburo@graduate.chiba-u.jp.
Tomemori
Takuya
T
Department of Otorhinolaryngology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Suzuki
Shuichi
S
Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan.
Arima
Takayasu
T
Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan.
Tomiita
Minako
M
Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan.
Shimojo
Naoki
N
Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan.
Kohno
Yoichi
Y
Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan.
D000284:Administration, Oral; D002648:Child; D018450:Disease Progression; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007634:Keratitis / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D013577:Syndrome
D007166:Immunosuppressive Agents; D008727:Methotrexate