title: Evolution of chiral Lewis basic N-formamide as highly effective organocatalyst for asymmetric reduction of both ketones and ketimines with an unprecedented substrate scope.
abstract: L-Pipecolinic acid derived Lewis basic N-formamide has been developed as a first highly effective catalyst for the asymmetric reduction of aromatic and aliphatic ketones as well as aromatic and aliphatic ketimines in good to high enantioselectivity.
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.forename: Zhouyu
authors.initials: Z
authors.lastname: Wang
authors.forename: Siyu
authors.initials: S
authors.lastname: Wei
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
mesh_terms: D002384:Catalysis; D005559:Formamides / Q000138:chemical synthesis / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry; D010084:Oxidation-Reduction; D010875:Pipecolic Acids / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D005559:Formamides; D007097:Imines; D007659:Ketones; D009930:Organic Chemicals; D010875:Pipecolic Acids