The flow of cytometry into systems biology.
Biomedical research is evolving to address biological systems as molecular pathways integrated into complex networks. Tools for molecular and cell analysis are also evolving to address the new challenges and opportunities of this approach. Flow cytometry is a versatile analytical platform, capable of high speed quantitative measurements of cells and other particles. These capabilities are being exploited and extended in a range of new applications stemming from opportunities presented by the advances of genomics, proteomics and systems biology, which are in turn impacting clinical diagnosis, vaccine development and drug discovery. In this review, we highlight some of these advances and consider the future evolution of flow cytometry technology.
Nolan
John P
JP
La Jolla Bioengineering Institute, 505 Coast Boulevard South, La Jolla, CA 92037, USA. jnolan@ljbi.org
Yang
Loretta
L
D005434:Flow Cytometry / Q000295:instrumentation / Q000379:methods*; D023281:Genomics; D006801:Humans; D040081:Protein Array Analysis; D040901:Proteomics; D049490:Systems Biology / Q000379:methods*