Evaluation of antidiabetic activity of Coldenia procumbens in alloxan-induced diabetes in rat.
Diabetes was induced in Groups II, III and IV rats by alloxan monohydrate at the rate of 180 mg/kg body weight. Body weight increased significantly (p < 0.05) after Coldenia procumbens treatment. Treatment with C. procumbens significantly (p < 0.05) reduced the blood glucose level from 394.17 +/- 10.52 (mg/dl) to 152.83 +/- 2.15 (mg/dl) in rats when compared with diabetic control group of rats. Serum triglyceride levels decreased significantly (p < 0.05) from 152.33 +/- 2.75 (mg/dl) to 109.17 +/- 1.74 (mg/dl) in C. procumbens-treated rats. Treatment with C. procumbens significantly (p < 0.05) reduced the serum cholesterol level from 59.83 +/- 1.01 (mg/dl) to 44.33 +/- 1.96 (mg/dl) in rats. The analysis of data indicates that the test drug has good hypoglycemic effect in diabetic rats.
Patel
Nita
N
Dept of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Gujarat, India.
Raval
Sunant
S
Goriya
Harshad
H
Jhala
Mayur
M
Joshi
Bhola
B
D000284:Administration, Oral; D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D028082:Boraginaceae; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan; D002784:Cholesterol