A new anticancer dihydroflavanoid from the root of Spiranthes australis (R. Brown) Lindl.
A new dihydroflavanoid was obtained from the root of Spiranthes australis (R. Brown) Lindl, a traditional Chinese medicinal herb. The structure was elucidated as (2S)-5,2',6'-trihydroxy-6-lavandulyl-4''-(gamma,gamma-dimethylallyl)-2'',2''-dimethylpyrano-[5'',6'' : 7,8]-flavanone by spectroscopic methods including UV, IR, HR-EI-MS, ESI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activities of the compound to inhibit human cancer cells' growth including A549, BEL-7402, SGC-7901, MCF-7, HT-29, K562, and A498 cell lines by MTT method was evaluated in vitro.
Peng
Jinyong
J
School of Pharmacy, Dalian Medical University, Dalian 116027, China. jinyongpeng2005@163.com
Xu
Qiwei
Q
Xu
Youwei
Y
Qi
Yan
Y
Han
Xu
X
Xu
Lina
L
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005562:Formazans / Q000737:chemistry; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D029595:Orchidaceae / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D005562:Formazans; D013778:Tetrazolium Salts; C079782:MTT formazan