title: Hemispherectomy in early infantile epileptic encephalopathy.
abstract: The authors report the successful surgical treatment of early infantile epileptic encephalopathy and suppression burst in 2 children with hemispheric dysplasia. At surgical evaluation, focal epileptic patterns were recorded from the abnormal hemisphere, and ictal single-photon emission computed tomography demonstrated ipsilateral regional hyperperfusion. Functional hemispherectomy was performed after electrocorticography revealed near-continuous spike and slow-wave discharges over the affected hemisphere. Histopathology revealed Taylor-type cortical dysplasia. Postoperatively, both patients are seizure free on antiepileptic drug monotherapy and have shown improved developmental status. Their favorable outcome demonstrates that children with early infantile epileptic encephalopathy due to unilateral malformations of cortical development may benefit from early surgical intervention.
authors.affiliation: Department of Neurology. Miami Children's Hospital, 3200 SW 60th Court, Miami, FL 33155, USA.
authors.forename: Lorie
authors.initials: L
authors.lastname: Hamiwka
authors.forename: Michael
authors.initials: M
authors.lastname: Duchowny
authors.forename: Israel
authors.initials: I
authors.lastname: Alfonso
authors.forename: Edward
authors.initials: E
authors.lastname: Liu
mesh_terms: D001927:Brain Diseases / Q000150:complications / Q000473:pathology; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D005260:Female; D038421:Hemispherectomy / Q000379:methods*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male