N(1)-acetyl-5-methoxykynuramine contrasts with other tryptophan metabolites by a peculiar type of NO scavenging: cyclization to a cinnolinone prevents formation of unstable nitrosamines.
Hardeland
R
R
Backhaus
C
C
Fadavi
A
A
Hess
M
M
D000081:Acetamides / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000378:metabolism; D007735:Kynuramine / Q000031:analogs & derivatives* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D009602:Nitrosamines / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011724:Pyridazines / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*
C511705:3-acetamidomethyl-6-methoxycinnolinone; D000081:Acetamides; D016166:Free Radical Scavengers; D009602:Nitrosamines; D011724:Pyridazines; D009569:Nitric Oxide; D007735:Kynuramine; C032131:N-acetyl-5-methoxy kynurenamine; D014364:Tryptophan