Role of red blood cell flow behavior in hemodynamics and hemostasis.
The primary role of red blood cells (RBCs) is to transport oxygen to the tissues, which is performed predominantly in the blood capillaries. However, RBCs have unique flow-affecting properties that play a key role in blood flow in all blood vessel types and sizes. While RBCs as oxygen carriers have been studied extensively, their hemodynamic function has been examined less comprehensively. This review aims to bridge this gap, focusing on the role of RBC flow properties in hemodynamics, hemostasis and thrombosis.
Barshtein
Gregory
G
Hebrew University-Hadassah Medical School, Department of Biochemistry, Jerusalem 91120, Israel. gregb@cc.huji.ac.il
Ben-Ami
Ronen
R
Yedgar
Saul
S
D001457:Anion Exchange Protein 1, Erythrocyte / Q000502:physiology; D001799:Blood Sedimentation; D004730:Endothelium, Vascular / Q000502:physiology; D004903:Erythrocyte Aggregation / Q000502:physiology; D004907:Erythrocyte Deformability / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology*; D005340:Fibrinogen / Q000502:physiology; D006400:Hematocrit; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D007136:Immunoglobulins / Q000502:physiology; D008833:Microcirculation / Q000502:physiology; D019158:N-Acetylneuraminic Acid / Q000502:physiology; D010973:Platelet Adhesiveness; D012039:Regional Blood Flow / Q000502:physiology*; D012212:Rheology; D013927:Thrombosis / Q000503:physiopathology
D001457:Anion Exchange Protein 1, Erythrocyte; D007136:Immunoglobulins; D005340:Fibrinogen; D019158:N-Acetylneuraminic Acid