title: A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery.
abstract: We show that the use of multiple photochemistries is necessary to ensure diverse immobilisation of small molecules for binding of polypeptides using phage display and antibody libraries.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.
authors.forename: Suzanne J
authors.initials: SJ
authors.lastname: Dilly
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Bell
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Clark
authors.forename: Andrew
authors.initials: A
authors.lastname: Marsh
authors.forename: Richard M
authors.initials: RM
authors.lastname: Napier
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Sergeant
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: Paul C
authors.initials: PC
authors.lastname: Taylor
mesh_terms: D015195:Drug Design; D019151:Peptide Library; D010455:Peptides / Q000378:metabolism; D010777:Photochemistry
chemical_list: D019151:Peptide Library; D010455:Peptides