Maternal exposure to polybrominated and polychlorinated biphenyls: infant birth weight and gestational age.
Understanding the influence of maternal exposures on gestational age and birth weight is essential given that pre-term and/or low birth weight infants are at risk for increased mortality and morbidity. We performed a retrospective analysis of a cohort exposed to polybrominated biphenyls (PBB) through accidental contamination of cattle feed and polychlorinated biphenyls (PCB) through residual contamination in the geographic region. Our study population consisted of 444 mothers and their 899 infants born between 1975 and 1997. Using restricted maximum likelihood estimation, no significant association was found between estimated maternal serum PBB at conception or enrollment PCB levels and gestational age or infant birth weight in unadjusted models or in models that adjusted for maternal age, smoking, parity, infant gender, and decade of birth. For enrollment maternal serum PBB, no association was observed for gestational age. However, a negative association with high levels of enrollment maternal serum PBB and birth weight was suggested. We also examined the birth weight and gestational age among offspring of women with the highest (10%) PBB or PCB exposure, and observed no significant association. Because brominated compounds are currently used in consumer products and therefore, are increasingly prevalent in the environment, additional research is needed to better understand the potential relationship between in utero exposure to brominated compounds and adverse health outcomes.
Givens
Marjory L
ML
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Small
Chanley M
CM
Terrell
Metrecia L
ML
Cameron
Lorraine L
LL
Michels Blanck
Heidi
H
Tolbert
Paige E
PE
Rubin
Carol
C
Henderson
Alden K
AK
Marcus
Michele
M
D000293:Adolescent; D000328:Adult; D001724:Birth Weight / Q000187:drug effects*; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure; D011075:Polybrominated Biphenyls / Q000097:blood / Q000633:toxicity*; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000633:toxicity*; D011247:Pregnancy; D012044:Regression Analysis
D004785:Environmental Pollutants; D011075:Polybrominated Biphenyls; D011078:Polychlorinated Biphenyls