title: Teflon granuloma results in a false-positive "second primary" on 18F-2-deoxyglucose positron emission tomography in a patient with a history of nasopharyngeal cancer.
abstract: 18F-2-deoxyglucose positron emission tomography (PET) is a frequent diagnostic tool used to evaluate patients with head and neck squamous cell carcinoma (HNSCC). 18F-2-deoxyglucose-PET is used in this setting for detection of metastases (staging) and/or second primaries. False-positive PET scans (10%-15% frequency) can distract from accurate HNSCC staging and an orderly prescription for treatment. Teflon (DuPont, Wilmington, DE) vocal fold injections can result in granuloma formation that has been described to generate a false-positive uptake on PET. We present a case of an injected vocal cord that appeared as a second laryngeal primary in a patient with recurrent nasopharyngeal cancer.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, Pennsylvania State University College of Medicine, Hershey, PA, USA.
authors.forename: Jonathon L
authors.initials: JL
authors.lastname: Chadwick
authors.forename: Ayesha
authors.initials: A
authors.lastname: Khalid
authors.forename: Henry
authors.initials: H
authors.lastname: Wagner
authors.forename: Brendan C
authors.initials: BC
authors.lastname: Stack
mesh_terms: D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000009:adverse effects*; D005500:Follow-Up Studies; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals / Q000009:adverse effects*; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18