Umbilical cord blood transplantation using non-myeloablative conditioning: the Mexican experience.
Twenty-eight children and adults underwent transplantation with allogeneic umbilical cord blood cells (UCB) using a non-ablative conditioning regimen; there were 15 males and 13 females. Seven patients were grafted because a non-malignant condition and 21 for a malignant disease. The median age was 8 years (range 4 months-72 years). Ten UCB were obtained from Mexican cord bloods banks, five cords were from compatible siblings and the remaining 13 cords were obtained from abroad. Median time to recover >0.5 x 10(9)/l granulocytes was 24 days (range 8-32 days), whereas median time to recover >20 x 10(9)/l platelets was 26 days (range 12-50 days). Twelve recipients never engrafted and recovered subsequently endogenous hematopoiesis. The non-engraftment rate was significantly higher in patients allografted for benign conditions (71%) than in those allografted for malignant conditions (28%). The median overall post-transplant survival (SV) was 33 months and the 73-months overall SV was 39%. The cumulative incidence of grade II-IV acute GVHD and grade III-IV GVHD for the entire cohort of patients were 14 and 7%, respectively. Additional studies are needed to define if non-myeloablative conditioning is preferable over conventional conditioning in the case of UCB allografting.
Mancías-Guerra
Consuelo
C
Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Nuero León, México.
Ruiz-Delgado
Guillermo J
GJ
Manzano
Carlos
C
Díaz-Hernandez
Maria Angeles
MA
Tarín-Arzaga
Luz C
LC
González-Llano
Oscar
O
Gómez-Almaguer
David
D
Ruiz-Argüelles
Guillermo J
GJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D005260:Female; D006085:Graft Survival; D006086:Graft vs Host Disease; D006801:Humans; D007223:Infant; D007700:Kinetics; D008297:Male; D008800:Mexico; D008875:Middle Aged; D015996:Survival Rate; D014019:Tissue Donors; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous