title: Elucidating the spectrum of alpha-thalassemia mutations in Iran.
abstract: Alpha thalassemia (alpha-thal) is one of the most common hemoglobin (Hb) disorders in the world. Alpha-globin genes are located on chromosome 16. The majority of alpha-thal mutations are deletions but point mutations are found as well. Since the Iranian population is a mixture of different ethnic groups, frequency and distribution of alpha-globin mutations in various regions of the country need to be clarified. These findings can contribute to a wider understanding of this disorder.
authors.affiliation: Kariminejad-Najmabadi Pathology & Genetics Center, 14665/154, Tehran, Iran.
authors.forename: Valeh
authors.initials: V
authors.lastname: Hadavi
authors.forename: Amir Hossein
authors.initials: AH
authors.lastname: Taromchi
authors.forename: Mahdi
authors.initials: M
authors.lastname: Malekpour
authors.forename: Behjat
authors.initials: B
authors.lastname: Gholami
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Law
authors.forename: Navid
authors.initials: N
authors.lastname: Almadani
authors.forename: Fariba
authors.initials: F
authors.lastname: Afroozan
authors.forename: Farhad
authors.initials: F
authors.lastname: Sahebjam
authors.forename: Parisa
authors.initials: P
authors.lastname: Pajouh
authors.forename: Roxana
authors.initials: R
authors.lastname: Kariminejad
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Kariminejad
authors.forename: Azita
authors.initials: A
authors.lastname: Azarkeivan
authors.forename: Maryam
authors.initials: M
authors.lastname: Jafroodi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Tamaddoni
authors.forename: Helene
authors.initials: H
authors.lastname: Puehringer
authors.forename: Christian
authors.initials: C
authors.lastname: Oberkanins
authors.forename: Hossein
authors.initials: H
authors.lastname: Najmabadi
mesh_terms: D005787:Gene Frequency; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D017720:Molecular Epidemiology; D009154:Mutation; D017085:alpha-Thalassemia / Q000453:epidemiology / Q000235:genetics*
chemical_list: D006455:Hemoglobins, Abnormal