title: Investigation of Keyes skin biopsy instrument for cervical biopsy procedures versus Kevorkian biopsy forceps.
abstract: OBJECTIVE
  We aimed to investigate the utility and efficacy of the Keyes skin biopsy instrument for cervical biopsy procedures.
  
  
  METHODS
  A prospective clinical trial was conducted on 50 women with cervical lesions. Colposcopy-guided cervical biopsies were collected using a Keyes biopsy punch and a Kevorkian biopsy forceps and the two methods were compared with definitive histopathological examination of the specimens obtained by the loop electrosurgical excision procedure (LEEP), conization or hysterectomy.
  
  
  RESULTS
  There were no differences in speed of collection, diagnostic value of specimens, complication rates, or sample quality. The sensitivity, specificity, positive and negative predictivity of specimens were all 100% for both methods.
  
  
  CONCLUSIONS
  The Keyes biopsy punch was found to be a safe, rapid and accurate diagnostic tool in cervical biopsy procedures. Based on the results of this study, the use of a Keyes punch instrument can be recommended as an alternative to other cervical biopsy methods.
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Women's and Children's Hospital, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ayas
authors.forename: I
authors.initials: I
authors.lastname: Aköz
authors.forename: A
authors.initials: A
authors.lastname: Gürbüz
authors.forename: E
authors.initials: E
authors.lastname: Eskicirak
authors.forename: H
authors.initials: H
authors.lastname: Cetiner
authors.forename: A
authors.initials: A
authors.lastname: Karateke
mesh_terms: D000328:Adult; D001707:Biopsy, Needle / Q000379:methods*; D002584:Cervix Uteri / Q000473:pathology*; D003127:Colposcopy / Q000379:methods*; D019092:Conization / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014421:Turkey; D002583:Uterine Cervical Neoplasms / Q000473:pathology*