Antidepressant-like effects of the traditional Chinese medicine kami-shoyo-san in rats.
Kami-shoyo-san (KSS), a traditional Chinese medicine, has been used to treat patients with neuropsychiatric disorders. The aim of the present paper was to investigate whether KSS has antidepressant-like effects, and to assess its mechanism of action, using male Sprague-Dawley rats given 10-fold (KSS 10X) or 20-fold (KSS 20X) the typical human daily dosage. Immobility time was measured by the forced swimming test, and hippocampal neurogenesis was quantified under immobilization stress. Rats given KSS 20X, but not those given KSS 10X, had a significantly lower immobility time and improved neurogenesis in the hippocampus. These results suggest that KSS possesses an antidepressant-like effect at a behavioral and molecular level.
Park
Sung-Woo
SW
Department of Neuropsychiatry, School of Medicine, Paik Inje Memorial Clinical Research Institute, Inje University, Busan, Korea.
Kim
Young-Koung
YK
Lee
Jung-Goo
JG
Kim
Sun-Hee
SH
Kim
Jae-Min
JM
Yoon
Jin-Sang
JS
Park
Yong-Ki
YK
Lee
Yong-Kyu
YK
Kim
Young-Hoon
YH
D000818:Animals; D000928:Antidepressive Agents; D000963:Antimetabolites; D001522:Behavior, Animal / Q000187:drug effects; D001973:Bromodeoxyuridine; D018891:Dentate Gyrus / Q000187:drug effects / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000473:pathology / Q000523:psychology; D013550:Swimming / Q000523:psychology
D000928:Antidepressive Agents; D000963:Antimetabolites; D004365:Drugs, Chinese Herbal; C103354:kamisyoyo san; D001973:Bromodeoxyuridine