Synthesis of 3-substituted 2-fluoro- and 2,2-difluoroaziridines.
A new route for the synthesis of stable 3-alkyl- and 3-aryl-2(,2)-(di)fluoroaziridines was developed by hydride reduction of novel alpha-bromo- and alpha-chloro-alpha(,alpha)-(di)fluoroketimines and subsequent ring closure of beta-fluorinated beta-chloro- and beta-bromoamines. This is the first report on the synthesis of 2,2-difluoroaziridines sensu stricto.
Van Hende
Eva
E
Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
Verniest
Guido
G
Surmont
Riccardo
R
De Kimpe
Norbert
N
D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D005461:Fluorine / Q000737:chemistry*
D001388:Aziridines; D005461:Fluorine