title: DNA electrochemical sensor based on an adduct of single-walled carbon nanotubes and ferrocene.
abstract: A novel electrochemical sandwich-type gene sensing system was designed by using a DNA probe (DNA-probe1) immobilized on a gold electrode, the target DNA, and another DNA probe (DNA-probe2) conjugated on a single-walled carbon nanotubes/ferrocene (Fc-SWNT) adduct. In this sandwich-type gene-sensing electrode, the Fc-SWNT adduct could significantly amplify the electrochemical response of the reduction of H(2)O(2). The target DNA could be detected selectively and sensitively based on the much enhanced electrochemical catalytic property of the Fc-SWNT adduct toward H(2)O(2) reduction.
authors.affiliation: School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Yang
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Lu
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Ma
authors.forename: Zunfeng
authors.initials: Z
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Du
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Chen
mesh_terms: D018736:DNA Adducts / Q000737:chemistry*; D015342:DNA Probes / Q000737:chemistry*; D004563:Electrochemistry / Q000295:instrumentation; D005296:Ferrous Compounds / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D000075163:Metallocenes; D008839:Microelectrodes; D037742:Nanotubes, Carbon / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D018736:DNA Adducts; D015342:DNA Probes; D005296:Ferrous Compounds; D000075163:Metallocenes; D037742:Nanotubes, Carbon; D006046:Gold; C004998:ferrocene