title: Effect of ovary lipid from Skipjack tuna (Katsuwonus pelamis) on brain monoamines in rats.
abstract: In our previous experiments with rats, ovary lipid from Skipjack Tuna (Katsuwonus pelamis) (OLS) was shown to have a mitigating effect on anxiety and/or fear in elevated T-maze tests. This suggests that OLS has some effect on the central nervous system (CNS) of rats. Thus, we performed experiments to examine the status of CNS in rats given OLS. The effect of OLS on chronic stress was also examined at the same time. The feed for control rats used oil and fat that have the same energy percentages for n-6 and n-3 fatty acids and the same n-6/n-3 ratio as OLS. As a result, rats given OLS for 28 days had lower serotonin levels in various brain areas regardless of stress application, showing that OLS affected the serotonin nervous system. From this, it was inferred that the ability of OLS to mitigate anxiety and/or fear resulted from its action on CNS, especially the serotonin nervous system. Substances other than the essential fatty acids may have been responsible for the action of OLS on monoamines and the metabolites. The effect of OLS on CNS, especially the serotonin nervous system, suggests that OLS may suppress anxiety.
authors.affiliation: Industrial Research Institute of Shizuoka Prefecture, Aoi, Shizuoka, Japan.
authors.forename: Katumasa
authors.initials: K
authors.lastname: Ookawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Eiji
authors.initials: E
authors.lastname: Shida
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ooba
authors.forename: Toru
authors.initials: T
authors.lastname: Matumoto
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hokari
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Yokogoshi
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008055:Lipids / Q000494:pharmacology*; D008125:Locus Coeruleus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010053:Ovary / Q000737:chemistry*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D014413:Tuna
chemical_list: D015306:Biogenic Monoamines; D008055:Lipids