title: A general and practical method of alkynyl indole and benzofuran synthesis via tandem Cu- and Pd-catalyzed cross-couplings.
abstract: A new tandem coupling approach to synthesize 2-alkynyl indoles and benzofurans is described. This reaction utilizes easily accessible gem-dibromovinyl substrates and terminal alkynes and proceeds via Pd/C- and CuI-catalyzed tandem Ullman/Sonogashira couplings.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Nagamochi
authors.forename: Yuan-Qing
authors.initials: YQ
authors.lastname: Fang
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D007211:Indoles; D010165:Palladium; D003300:Copper