Aromatase inhibitors and musculoskeletal pain in patients with breast cancer.
Aromatase inhibitors are recommended for use by postmenopausal women who have estrogen receptor-positive early-stage breast cancer. They reduce local and distant recurrence more effectively than tamoxifen. Anastrozole (Arimidex, AstraZeneca Pharmaceuticals LP), letrozole (Femara, Novartis Pharmaceuticals Corporation), and exemestane (Aromasin, Pfizer Inc.) inhibit aromatase activity, thus significantly decreasing estrogen production in tissues such as liver, muscle, and fat. Very low levels of estrogen may be one cause of musculoskeletal pain, a common side effect associated with the drugs. In the major adjuvant aromatase inhibitor clinical trials, 25%-30% of the patients enrolled experienced musculoskeletal pain. Although quality-of-life studies demonstrate that aromatase inhibitors are well tolerated overall, some women discontinue this treatment because of musculoskeletal pain. Little is known about how to predict, measure, or manage musculoskeletal pain caused by aromatase inhibition. Oncology nurses play an important role in the assessment and management of side effects related to cancer. This article provides an overview of the current knowledge about musculoskeletal pain in patients with breast cancer receiving aromatase inhibitor therapy.
Winters
Loren
L
Cancer Center, Massachusetts General Hospital, Boston, USA. lwinters@partners.org
Habin
Karleen
K
Gallagher
Joan
J
D000077384:Anastrozole; D000730:Androstadienes / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D047072:Aromatase Inhibitors / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D016903:Drug Monitoring / Q000451:nursing; D005260:Female; D006801:Humans; D009140:Musculoskeletal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D009570:Nitriles / Q000009:adverse effects; D024802:Nurse's Role; D009730:Nursing Assessment; D015399:Nursing Research; D009859:Oncology Nursing / Q000458:organization & administration; D010146:Pain / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D059408:Pain Management; D010147:Pain Measurement; D010347:Patient Care Planning; D010353:Patient Education as Topic; D018579:Patient Selection; D017698:Postmenopause; D011788:Quality of Life; D011960:Receptors, Estrogen; D016896:Treatment Outcome; D014230:Triazoles / Q000009:adverse effects
D000730:Androstadienes; D000970:Antineoplastic Agents; D047072:Aromatase Inhibitors; D009570:Nitriles; D011960:Receptors, Estrogen; D014230:Triazoles; D000077384:Anastrozole; C056516:exemestane