Sequential polymicrobial infections lead to CNS inflammatory disease: possible involvement of bystander activation in heterologous immunity.
VV(PLP) is a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) that has been used to investigate molecular mimicry and autoimmunity. Since virus infections can cause bystander activation, mice were first infected with VV(PLP), and later challenged with wild-type VV, lymphocytic choriomeningitis virus (LCMV), or murine cytomegalovirus (MCMV). Among the VV(PLP)-primed mice, only MCMV challenge induced significant Ki-67(+), CD3(+)T cell infiltration into the central nervous system (CNS) with a mild PLP antibody response. While MCMV alone caused no CNS disease, control VV-infected mice followed with MCMV developed mild CNS inflammation. Thus, heterologous virus infections can induce CNS pathology.
Tsunoda
Ikuo
I
Department of Neurology, University of Utah School of Medicine, 3R330 SOM, Salt Lake City, Utah 84132-2305, United States.
Libbey
Jane E
JE
Fujinami
Robert S
RS
D000818:Animals; D020274:Autoimmune Diseases of the Nervous System / Q000209:etiology* / Q000473:pathology / Q000821:virology*; D024201:Bystander Effect / Q000276:immunology*; D049109:Cell Proliferation; D002494:Central Nervous System Infections / Q000150:complications* / Q000821:virology*; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental; D005260:Female; D005786:Gene Expression Regulation; D007156:Immunologic Memory; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008217:Lymphocytic choriomeningitis virus; D051379:Mice; D018146:Muromegalovirus; D018991:Myelin Proteolipid Protein; D011994:Recombinant Proteins / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology; D014616:Vaccinia virus
D018991:Myelin Proteolipid Protein; D011994:Recombinant Proteins