title: In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus.
abstract: Peptides with broad-spectrum antimicrobial activity, known as antimicrobial peptides, have been isolated from distinct organisms. This paper describes the in vitro evaluation of the cytotoxicity and antiviral activity of nine peptides with different structures and origins against herpes simplex virus type 1, human adenovirus respiratory strain, and rotavirus SA11. Most of the evaluated peptides presented antiviral activity but they were only active near cytotoxic concentrations. Nevertheless, these results seem promising, and further modifications on the peptide's structures may improve their selectivity and reduce their cytotoxicity.
authors.affiliation: Laboratório de Virologia Aplicada, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, Brasil.
authors.forename: Márcia Cristina
authors.initials: MC
authors.lastname: Carriel-Gomes
authors.forename: Jadel Müller
authors.initials: JM
authors.lastname: Kratz
authors.forename: Margherita Anna
authors.initials: MA
authors.lastname: Barracco
authors.forename: Evelyne
authors.initials: E
authors.lastname: Bachére
authors.forename: Célia Regina Monte
authors.initials: CR
authors.lastname: Barardi
authors.forename: Cláudia Maria Oliveira
authors.initials: CM
authors.lastname: Simões
mesh_terms: D000256:Adenoviridae / Q000187:drug effects*; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D012401:Rotavirus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D023181:Antimicrobial Cationic Peptides; D000998:Antiviral Agents