title: Evaluation of three antimicrobial regimens used as metaphylaxis in stocker calves at high risk of developing bovine respiratory disease.
abstract: A total of 894 calves at high risk for bovine respiratory disease were processed at two sites and randomly assigned to receive one of three antimicrobial metaphylactic regimens to determine if a two-drug regimen offered any advantage over the more conventional one-course regimens. On arrival, calves received either a two-course regimen of ceftiofur crystalline free acid (CCFA) followed by tulathromycin 8 days later (Group 1) or a one-course regiment of CCFA (Group 2) or tilmicosin (Group 3). At Site A, morbidity was significantly lower (52%) in Group 1 than in Group 2 (76.3%) and Group 3 (78.4%). At Site B, morbidity was significantly lower in Group 1 (2.6%) than in Group 2 (9.4%) and Group 3 (7.2%).
authors.affiliation: Department of Veterinary Clinical Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Step
authors.forename: Terry
authors.initials: T
authors.lastname: Engelken
authors.forename: Cristina
authors.initials: C
authors.lastname: Romano
authors.forename: Ben
authors.initials: B
authors.lastname: Holland
authors.forename: Clint
authors.initials: C
authors.lastname: Krehbiel
authors.forename: John C
authors.initials: JC
authors.lastname: Johnson
authors.forename: W Lawrence
authors.initials: WL
authors.lastname: Bryson
authors.forename: Cassius M
authors.initials: CM
authors.lastname: Tucker
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Robb
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D048090:Bovine Respiratory Disease Complex / Q000401:mortality / Q000517:prevention & control*; D002417:Cattle; D002511:Cephalosporins / Q000627:therapeutic use*; D004187:Disaccharides / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D008297:Male; D012307:Risk Factors; D016896:Treatment Outcome; D018942:Macrolides
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004187:Disaccharides; D006571:Heterocyclic Compounds; C053503:ceftiofur; C485204:tulathromycin; D018942:Macrolides