[Carnosine--biological activity and perspectives in pharmacotherapy].
This review summarizes the data on biological activity and therapeutic potential of camosine. Camosine is a naturally occurring, water-soluble dipeptide. It has buffering activities in excitable animal and human tissues, exhibits metal ions binding properties, antioxidant and antiglycating properties, extends the life-span of cultured human diploid cells, regulates sarcoplasmic reticulum Ca-release channel activity. Carnosine may be a potential therapeutic agent (neurodegenerative, metabolic, cardiovascular diseases) mainly due to its antioxidant and antiglycating activities.
Zieba
Remigiusz
R
Z Zakładu Farmakodynamiki Uniwersytetu Medycznego w łodzi. remusz@wp.pl
D000409:Alanine / Q000737:chemistry; D000544:Alzheimer Disease / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000187:drug effects; D000818:Animals; D000975:Antioxidants; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002336:Carnosine / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology* / Q000627:therapeutic use; D004358:Drug Therapy / Q000639:trends*; D016166:Free Radical Scavengers / Q000378:metabolism; D006639:Histidine / Q000737:chemistry; D006801:Humans; D008670:Metals / Q000378:metabolism; D018763:Muscle Fatigue / Q000187:drug effects / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats
D016229:Amyloid beta-Peptides; D000975:Antioxidants; D015220:Calcium Channels; D016166:Free Radical Scavengers; D008670:Metals; D006639:Histidine; D002336:Carnosine; D000409:Alanine