title: Disseminated histoplasmosis with lesions restricted to the larynx in a patient with AIDS. Report of a case and review of the literature.
abstract: Histoplasmosis is an endemic and systemic mycosis, caused by the dimorphic fungus Histoplasma capsulatum var capsulatum. Disseminated disease in immunocompromised patients generally results from the reactivation of latent foci after a prolonged period of asymptomatic infection. We report a case of laryngeal histoplasmosis as the unique clinical manifestation of a progressive form of the disease in a patient with advanced HIV/AIDS disease. Histopathological analysis of laryngeal biopsy smears revealed granulomas containing Histoplasma-like organisms. Treatment with amphotericin B followed by itraconazole resulted in complete remission of laryngeal lesions. To our knowledge, this is the third case report of laryngeal histoplasmosis in a patient with AIDS.
authors.affiliation: División de HIV/SIDA, Hospital de Enfermedades Infecciosas Francisco Javier Muñiz, Buenos Aires, Argentina.
authors.forename: Rubén
authors.initials: R
authors.lastname: Solari
authors.forename: Marcelo
authors.initials: M
authors.lastname: Corti
authors.forename: Diana
authors.initials: D
authors.lastname: Cangelosi
authors.forename: Manuel
authors.initials: M
authors.lastname: Escudero
authors.forename: Ricardo
authors.initials: R
authors.lastname: Negroni
authors.forename: Christian
authors.initials: C
authors.lastname: Saccheri
authors.forename: Ricardo
authors.initials: R
authors.lastname: Schtirbu
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D003680:Deglutition Disorders / Q000209:etiology; D006660:Histoplasmosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007827:Laryngitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016312:Treatment Refusal
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B