Visceral adipocytes and the metabolic syndrome.
Recently, the high responsiveness of omental adipocytes to positive lipolytic stimuli has been clearly demonstrated in women. We conclude that adipose tissue fatty acid release, storage capacity, and secreted cytokines may all be involved in the etiology of the metabolic syndrome. The anatomical location of visceral adipocytes close to the liver, combined with possible depot-specific alterations in various adipocyte or adipose tissue features likely play critical roles in this process. This highly complex etiology is concordant with the heterogeneous clinical manifestations of the metabolic syndrome, and suggests possible interindividual variability in the extent to which each pathophysiological mechanism is involved.
Tchernof
André
A
Molecular Endocrinology and Oncology Research Center, Department of Nutrition, Laval University Medical Research Center and Laval University, Quebec City, Province of Quebec, Canada. andre.tchernof@crchul.ulaval.ca
D050218:Body Fat Distribution; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism* / Q000503:physiopathology; D008099:Liver / Q000378:metabolism* / Q000503:physiopathology; D024821:Metabolic Syndrome / Q000209:etiology* / Q000378:metabolism*; D009852:Omentum; D012307:Risk Factors