title: [Two types of NP-NP associations in influenza virus-infected cells].
abstract: Two types of NP-NP associations are shown to form in the influenza virus-infected cells. Early NP synthesis gives rise to NP associations stabilized by relatively weak bonds. These structures are designed as NP multimers. The high protease- and heat-sensitivities allow NP-multimers to be regarded as incompletely folded proteins. Post-translationally, NP-multimers transform to compact NP associations (NP oligomers) that are relatively highly heat-and protease-resistant. The NP-multimers untransformed to the folded compact NP-oligomers accumulate in the cells and partially degraded. Whether both types of NP-NP associations may be of significance is under discussion.
authors.forename: N P
authors.initials: NP
authors.lastname: Semenova
authors.forename: V M
authors.initials: VM
authors.lastname: Chumakov
authors.forename: T A
authors.initials: TA
authors.lastname: Grigor'eva
authors.forename: I A
authors.initials: IA
authors.lastname: Rudneva
authors.forename: V V
authors.initials: VV
authors.lastname: Burov
authors.forename: E N
authors.initials: EN
authors.lastname: Prokudina
mesh_terms: D000818:Animals; D002460:Cell Line; D006358:Hot Temperature; D029521:Alphainfluenzavirus / Q000145:classification / Q000378:metabolism*; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins / Q000378:metabolism*; D009976:Orthomyxoviridae Infections / Q000821:virology*; D010447:Peptide Hydrolases / Q000494:pharmacology; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D016601:RNA-Binding Proteins / Q000378:metabolism*; D013045:Species Specificity; D014758:Viral Core Proteins / Q000378:metabolism*
chemical_list: C048842:NP protein, Influenza A virus; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D016601:RNA-Binding Proteins; D014758:Viral Core Proteins; D010447:Peptide Hydrolases