Effects of Salvia officinalis L. extract on experimental acute inflammation.
The aim of this study was to investigate the effects of Salvia officinalis L. tincture on acute inflammation induced with oil of turpentine.


METHODS
Oil of turpentine (i.m. 0.6 ml/100 g b.w.) was injected into male Wistar rats right hind paw. Salviae folium tincture and diclofenac as positive control (30 mg/100 g b.w.) were administrated i.p. The effects were evaluated by measuring total leukocyte count and differential leukocyte count expressed as a percentage, a test of in vitro phagocytosis and evaluation of nitric oxide synthesis by measuring the metabolites: nitrites and nitrates.


RESULTS
Salvia officinalis tincture significantly reduced the total leukocyte and monocytes percentages and the activation of circulating phagocytes. NO synthesis had a slight decrease. Salvia officinalis tincture had a smaller inhibitory effect than diclofenac.


CONCLUSIONS
Salvia officinalis tincture had antiinflammatory effects by reducing marrow acute phase response and NO synthesis.
Oniga
Ilioara
I
Department of Pharmacognosy, School of Pharmacy, "I. Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca.
Pârvu
Alina Elena
AE
Toiu
Anca
A
Benedec
Daniela
D
D000210:Acute-Phase Reaction; D000818:Animals; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D007509:Irritants / Q000009:adverse effects; D008297:Male; D023421:Models, Animal; D009569:Nitric Oxide / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027543:Salvia officinalis / Q000737:chemistry*; D014425:Turpentine / Q000009:adverse effects
D007509:Irritants; D010936:Plant Extracts; D009569:Nitric Oxide; D014425:Turpentine