Monte Carlo modeling of optoacoustic signals from human internal jugular veins.
Monitoring of blood oxygenation, in particular, cerebral venous oxygenation, is necessary for management of a variety of life-threatening conditions. An optoacoustic technique can be used for noninvasive monitoring of blood oxygenation in blood vessels, including large veins. We calculated optoacoustic signals from a cylinder mimicking a blood vessel using a modified Monte Carlo code and analyzed their temporal profiles. The rate of decrease of the integrated optoacoustic signal at different wavelengths of incident near-infrared radiation was related to the effective attenuation coefficient of normally oxygenated venous blood. We obtained good correlation of this parameter with the blood effective attenuation coefficient in a wide spectral range that may be useful in providing an accurate and robust optoacoustic monitoring of blood oxygenation. We also estimated the accuracy of effective attenuation coefficient calculations.
Patrikeev
Igor
I
Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, 77555-0456, USA.
Petrov
Yuriy Y
YY
Petrova
Irina Y
IY
Prough
Donald S
DS
Esenaliev
Rinat O
RO
D003198:Computer Simulation; D006801:Humans; D007259:Infrared Rays; D007601:Jugular Veins / Q000000981:diagnostic imaging* / Q000502:physiology*; D008955:Models, Cardiovascular; D015233:Models, Statistical; D009010:Monte Carlo Method; D010092:Oximetry / Q000379:methods*; D013055:Spectrophotometry, Infrared / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*