title: Thyroid medullary carcinoma in a teenager with Cowden syndrome.
abstract: Cowden syndrome is a multisystemic cancer predisposition disorder, in which the mucocutaneous lesions are the most constant features. We present a case of Cowden syndrome in a teenage boy with hyperkeratotic papules of the facial skin, especially on the eyelids, with episcleritis, proptosis, and papillomatous lesions on the tip of the tongue and lip mucosa. In addition, two nodules in the thyroid gland were detected. On laboratory examination, the carcinoembryonic antigen (CEA) was 34 ng/mL (normal limits: 0-3 ng/mL). Total thyroidectomy was performed. Histopathologic examination of the specimen revealed thyroid medullary carcinoma. After operation, levels of CEA decreased to normal limits.
authors.affiliation: Department of Pediatric Oncology, Selcuk University, Meram Medical Faculty, Konya, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Koksal
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.forename: Hande
authors.initials: H
authors.lastname: Koksal
authors.forename: Diclehan
authors.initials: D
authors.lastname: Orhan
authors.forename: Ekrem
authors.initials: E
authors.lastname: Unal
authors.forename: Engin
authors.initials: E
authors.lastname: Alagoz
mesh_terms: D000293:Adolescent; D002272:Carcinoembryonic Antigen / Q000097:blood; D018276:Carcinoma, Medullary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy; D014059:Tongue
chemical_list: D002272:Carcinoembryonic Antigen