Antidyslipidemic activity of Indigofera tinctoria.
Indigofera tinctoria is a perennial shrub, which belongs to the family Papilionaceae. As a part of our drug discovery program we have investigated the antidyslipidemic activity of the alcoholic extract from Indigofera tinctoria as well as its three other components, that is, chloroform, butanol and aqueous fractions in dyslipidemic hamsters that were fed a high fat diet. The chloroform fraction showed a significant decrease in the plasma triglycerides (TG, 52%) (P < 0.001), total cholesterol (TC, 29%) (P < 0.05), glycerol (Gly, 24%) and free fatty acids (FFA, 14%). This decrease was also accompanied by an increase in high density lipoproteins (HDL) by 9% and an increased HDL-C/TC ratio of 52% at the dose of 250 mg/kg of body weight.
Puri
Anju
A
Biochemistry Division of CDRI, Lucknow, India.
Khaliq
Tanvir
T
Rajendran
S M
SM
Bhatia
Geetika
G
Chandra
Ramesh
R
Narender
Tadigoppula
T
D000284:Administration, Oral; D000818:Animals; D000440:Butanols / Q000008:administration & dosage* / Q000737:chemistry; D002725:Chloroform / Q000008:administration & dosage* / Q000737:chemistry; D002784:Cholesterol / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D006224:Cricetinae; D004041:Dietary Fats; D004305:Dose-Response Relationship, Drug; D005990:Glycerol / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D029883:Indigofera / Q000737:chemistry*; D008075:Lipoproteins, HDL / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage; D010946:Plants, Medicinal / Q000737:chemistry; D014280:Triglycerides / Q000378:metabolism
D000440:Butanols; D002788:Cholesterol Esters; D008078:Cholesterol, LDL; D004041:Dietary Fats; C059714:HDL cholesteryl ester; D000960:Hypolipidemic Agents; D008075:Lipoproteins, HDL; D010936:Plant Extracts; D014280:Triglycerides; D002725:Chloroform; D002784:Cholesterol; D005990:Glycerol