title: Bcl-2 and MALT1 Genes are not involved in the oncogenesis of uterine tumors resembling ovarian sex cord tumors.
abstract: Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare entities. They were described by Clement and Scully in 1976 who classified them into groups I and II. Group I comprises typical endometrial stromal neoplasms with focal areas resembling ovarian sex cord elements and group II are predominantly or completely composed of ovarian sex cord-like elements. We report a case of UTROSCT type II with cytogenetic analysis. The tumor occurred in a 76-year-old woman who presented with vaginal bleeding. The tumor was lobulated, firm, yellow and histologically composed of sex cord-like elements. Tumor cells expressed vimentin, CD10, CD99 and alpha-actin. Cytogenetic analysis in a previously reported case detected translocation t(4;18)(q21.1;q21.3) in the majority of cells. Bcl-2 and MALT1 genes are located at or near the translocation breakpoints, and the aim of this study was to determine whether these genes were involved in chromosomal translocation or tumorigenesis. We did not find IgH translocation or the most common MALT translocations. Bcl-2 was also not involved in this oncogenesis.
authors.affiliation: Department of Clinical Pathology and Cytology, Clinical Hospital Merkur, Zagreb, Croatia. sitic.st@inet.hr
authors.forename: Sanda
authors.initials: S
authors.lastname: Sitic
authors.forename: Petra
authors.initials: P
authors.lastname: Korac
authors.forename: Petra
authors.initials: P
authors.lastname: Peharec
authors.forename: Gojko
authors.initials: G
authors.lastname: Zovko
authors.forename: Marija Milkovic
authors.initials: MM
authors.lastname: Perisa
authors.forename: Slavko
authors.initials: S
authors.lastname: Gasparov
mesh_terms: D000071443:12E7 Antigen; D000199:Actins / Q000235:genetics / Q000378:metabolism; D000368:Aged; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D020169:Caspases / Q000235:genetics / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D015260:Neprilysin / Q000235:genetics / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000502:physiology*; D018312:Sex Cord-Gonadal Stromal Tumors / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D014178:Translocation, Genetic / Q000235:genetics; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D014599:Uterus / Q000473:pathology / Q000503:physiopathology; D014746:Vimentin / Q000235:genetics / Q000378:metabolism
chemical_list: D000071443:12E7 Antigen; D000199:Actins; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D014746:Vimentin; D020169:Caspases; C400109:MALT1 protein, human; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D015260:Neprilysin