title: A complete response with rituximab in metastatic diffuse large B-cell lymphoma of the testis: case report.
abstract: Primary testicular lymphoma is an uncommon testicular tumour. We present a case of a primary non-Hodgkin lymphoma of the testis, describing its clinical and pathological features and discussing our treatment strategy. A 68-year-old man showed a firm erythematous testicular mass within the right emiscrotum. Subsequent ultrasonography demonstrated a right inferior pole testicular mass with disomogenously hypoecogenic. The patient was submitted to inguinal orchidectomy. Light microscopy demonstrated the classic appearance of a diffuse large B-cell lymphoma. The immunohistochemical study showed tumour cells intensively positive for CD45, Ki67 and CD20. No evidence of extra-testicular involvement by lymphoma was found. At 6 months, a TC-PET showed a clinical relapse in lung and abdominal lymphonodes, while clinical examination demonstrated a single, indolent and erythematous nodule in the left foot. The histologic analysis confirmed diagnosis of CD-20 positive B-cell lymphoma. The patient was treated with an anti-CD 20 monoclonal antibody (rituximab) alone every 3 weeks. After 3 months a complete response was observed in all sites of disease. The patient was free from disease at 12 months follow-up.
authors.affiliation: Department of Urology, Second University, Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Autorino
authors.forename: M G
authors.initials: MG
authors.lastname: Lamendola
authors.forename: M
authors.initials: M
authors.lastname: De Sio
authors.forename: R A
authors.initials: RA
authors.lastname: Di Trolio
authors.forename: F
authors.initials: F
authors.lastname: Ferraraccio
authors.forename: G
authors.initials: G
authors.lastname: Di Lorenzo
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D000069283:Rituximab; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab