Vincristine-induced acute neurotoxicity versus Guillain-Barré syndrome: a diagnostic dilemma.
We report the case of a patient with acute lymphoblastic leukaemia who, after the initiation of treatment with vincristine (VCR), developed a fulminant motor polyradiculoneuropathy resembling an axonal variant of Guillain-Barré syndrome (GBS). This report shows that differentiating between axonal GBS and VCR-induced acute neurotoxicity may be a challenge for clinicians.
González Pérez
P
P
Department of Neurology and Clinical Neurophysiology, University Hospital Vírgen del Rocio, Seville, Spain. palgonp@yahoo.es
Serrano-Pozo
A
A
Franco-Macías
E
E
Montes-Latorre
E
E
Gómez-Aranda
F
F
Campos
T
T
D000200:Action Potentials; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D003937:Diagnosis, Differential; D007172:Erectile Dysfunction / Q000139:chemically induced; D017809:Fatal Outcome; D020275:Guillain-Barre Syndrome / Q000175:diagnosis*; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D020335:Paraparesis / Q000139:chemically induced; D010292:Paresthesia / Q000139:chemically induced; D011129:Polyradiculoneuropathy / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D014555:Urination Disorders / Q000139:chemically induced; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects*
D003561:Cytarabine; D014750:Vincristine; D003907:Dexamethasone; D011241:Prednisone; D006854:Hydrocortisone; D008727:Methotrexate; D003630:Daunorubicin