[Troponin-I and creatinkinase-mb values for detection of cardiovascular system damage in children with recurrent respiratory tract disease].
84 patients 3-15 years of age were observed at the department of cardio-rheumatology of the Research Institute of Pediatrics, the laboratory "Test" and the laboratory department of the clinic "Guli". The patients with tonsillitis and recurrent respiratory tract disease were investigated. The patients were divided into study and control groups; The study group included children with signs of cardiovascular system damage according to the clinical and instrumental findings. Cross-sectional study was conducted. Cardiac Troponin-I was measured in serum by ELISA. Ck-MB was measured by colorimetric method. In the cases of cardiovascular system damage significant rise of Tp-I levels in 48,2%; and Ck-MB levels in 36.5% has been found. In 39% of cases positive was only Tp-I, (Ck-MB was negative in this 39% of cases). The study allows to use investigated markers as the diagnostic criteria of cardiovascular damage, to reveal the high risk group in children with tonsillitis and recurrent respiratory tract disease, as they really represent the candidates for future meaningful damage to cardiovascular system, which will require itself further monitoring of clinical and laboratory parameters and including of prevention activities in their life style.
Tsabutashvili
A V
AV
Barabadze
K N
KN
Vekua
M V
MV
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012140:Respiratory Tract Diseases / Q000150:complications; D014069:Tonsillitis / Q000150:complications; D019210:Troponin I / Q000097:blood*
D015415:Biomarkers; D019210:Troponin I; D003402:Creatine Kinase