title: Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells.
abstract: Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.
authors.affiliation: Technology Innovation Center for Life Science, Cheju National University, Jeju, Korea.
authors.forename: Hoon-Seok
authors.initials: HS
authors.lastname: Yoon
authors.forename: Sun-Ryung
authors.initials: SR
authors.lastname: Lee
authors.forename: Hee-Chul
authors.initials: HC
authors.lastname: Ko
authors.forename: Soo-Youn
authors.initials: SY
authors.lastname: Choi
authors.forename: Ji-Gweon
authors.initials: JG
authors.lastname: Park
authors.forename: Jeong-Kook
authors.initials: JK
authors.lastname: Kim
authors.forename: Se-Jae
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology*; D047309:Flavones / Q000502:physiology*; D005419:Flavonoids / Q000502:physiology*; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000201:enzymology* / Q000209:etiology; D051379:Mice; D014442:Monophenol Monooxygenase / Q000502:physiology
chemical_list: D047309:Flavones; D005419:Flavonoids; D008543:Melanins; C008661:nobiletin; D014442:Monophenol Monooxygenase; D048049:Extracellular Signal-Regulated MAP Kinases