[Influence of polycythaemia on erythrodieresis].
Influence of the polycythaemia on peritoneal and splenic macrophage function and NO production was studied. Interaction of peritoneal and splenic macrophages with autologous erythrocytes was examined. Concentration of nitrate ions (stable metabolites ofnitric oxide) was measured in peritoneal lavage, splenic cells suspension, blood, as well as in supernatant of peritoneal and splenic macrophages. The data obtained suggest that splenic macrophages from intact rats are more active than the peritoneal ones. Splenic macrophage activity decreases whereas that of peritoneal macrophages stays unaltered in polycythaemia. Concentration of nitrate ions is significantly increased in this condition.
Golubeva
E K
EK
Nazarov
S B
SB
D000818:Animals; D002450:Cell Communication; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000378:metabolism* / Q000473:pathology; D005260:Female; D017737:Macrophages, Peritoneal / Q000378:metabolism* / Q000473:pathology; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D011086:Polycythemia / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D013154:Spleen / Q000378:metabolism / Q000473:pathology
D009566:Nitrates; D009569:Nitric Oxide