title: Non-Hodgkin's lymphoma of nasal cavity and paranasal sinuses. A clinicopathological and immunohistochemical study.
abstract: Aim of this study was to investigate the clinical characteristics, management and prognosis of non-Hodgkin lymphomas of the nasal cavity and paranasal sinuses. Overall 12 patients with non-Hodgkin malignant lymphoma, at our Institute, were studied over an eight-year period from 1997 to 2005. Patients' data collected were age, sex, presenting signs and symptoms, histology, treatment, complications, and outcome. Also available were computerised tomography findings, and paraffin-embedded tissue bocks. Mean age was 62 years (range: 42-81), with a male dominance (male to female ratio: 7:5). Most patients had not presented any specific symptoms, such as nasal obstruction, headaches, epistaxis and facial swelling. Using immunocytochemistry on paraffin-embedded tissue sections, the predominance of large B-cell subtype was detected. Treatment administered: only radiotherapy (stage IEA) or in combination with chemotherapy (IIE-IVE). Of these patients, 5 died from the disease, 4 survived without disease, 2 survived with the disease, and one died of non-related causes. Non-Hodgkin's lymphomas are relatively rare. Early diagnosis, based mainly on tissue biopsy and computerised tomography, is essential in the management of non-Hodgkin lymphoma.
authors.affiliation: Department of Otolaryngology, Medical School, University of Athens, Hippokration Hospital, Athens, Greece.
authors.forename: T
authors.initials: T
authors.lastname: Chalastras
authors.forename: A
authors.initials: A
authors.lastname: Elefteriadou
authors.forename: J
authors.initials: J
authors.lastname: Giotakis
authors.forename: K
authors.initials: K
authors.lastname: Soulandikas
authors.forename: S
authors.initials: S
authors.lastname: Korres
authors.forename: E
authors.initials: E
authors.lastname: Ferekidis
authors.forename: D
authors.initials: D
authors.lastname: Kandiloros
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009367:Neoplasm Staging; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology* / Q000628:therapy; D014057:Tomography, X-Ray Computed