Dopamine-mushroom body circuit regulates saliency-based decision-making in Drosophila.
Drosophila melanogaster can make appropriate choices among alternative flight options on the basis of the relative salience of competing visual cues. We show that this choice behavior consists of early and late phases; the former requires activation of the dopaminergic system and mushroom bodies, whereas the latter is independent of these activities. Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila.
Zhang
Ke
K
Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), 320 Yueyang Road, Shanghai 200031, China.
Guo
Jian Zeng
JZ
Peng
Yueqing
Y
Xi
Wang
W
Guo
Aike
A
D000818:Animals; D030801:Animals, Genetically Modified; D001369:Axons / Q000502:physiology*; D001522:Behavior, Animal; D002755:Choice Behavior; D003463:Cues; D004298:Dopamine / Q000502:physiology*; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry; D023421:Models, Animal; D024521:Mushroom Bodies / Q000294:innervation* / Q000502:physiology*; D009154:Mutation; D013696:Temperature; D013997:Time Factors
D004298:Dopamine