Kipukasins, nucleoside derivatives from Aspergillus versicolor.
Seven new aroyl uridine derivatives (kipukasins A-G; 1-7) were isolated from solid-substrate fermentation cultures of two different Hawaiian isolates of Aspergillus versicolor. The structures of compounds 1-7 were determined by analysis of NMR and MS data. The nucleoside portion of lead compound 1 was assigned as uracil-1-beta-D-ribofuranoside by spectral comparison with an authentic standard. The bioactivity of the original A. versicolor extracts was accounted for mainly by the presence of the known metabolite sterigmatocystin, but kipukasins A and B showed modest activity in assays against Gram-positive bacteria.
Jiao
Ping
P
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Mudur
Sanjay V
SV
Gloer
James B
JB
Wicklow
Donald T
DT
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006254:Hawaii; D008826:Microbial Sensitivity Tests; D009183:Mycotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009705:Nucleosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013241:Sterigmatocystin / Q000302:isolation & purification / Q000494:pharmacology; D014529:Uridine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009183:Mycotoxins; D009705:Nucleosides; C523219:kipukasin A; C523220:kipukasin B; D013241:Sterigmatocystin; D014529:Uridine