Determination of the dialdehyde glyoxal in workroom air-development of personal sampling methodology.
The dialdehyde glyoxal (ethanedial) is an increasingly used industrial chemical with potential occupational health risks. This study describes the development of a personal sampling methodology for the determination of glyoxal in workroom air. Among the compounds evaluated as derivatizing agents; N-methyl-4-hydrazino-7-nitrobenzofurazan (MNBDH), 1,2-phenylenediamine (OPDA), 1-dimethylaminonaphthalene-5-sulfonylhydrazine (dansylhydrazine, DNSH) and 2,4-dinitrophenylhydrazine (DNPH), DNPH was the only reagent that was suitable. Several different samplers were evaluated for sampling efficiency of glyoxal in workroom air using DNPH as derivatizing agent; in-house DNPH coated silica particles packed in two different types of glass tubes, impingers containing acidified DNPH solution, filter cassettes containing glass fibre filters coated with DNPH, a commercially available solid phase cartridge sampler originally developed for formaldehyde sampling (Waters Sep-Pak DNPH-silica cartridge), and the commercially available SKC UMEx 100 passive sampler originally developed for formaldehyde sampling. Aldehyde atmospheres for sampler evaluation were generated with an in-house made vapour atmosphere generator coupled to a sampling unit, with the possibility of parallel sampling. The resulting glyoxal-DNPH derivative was determined using both LC-UV and LC-APCI-MS with negative ionization. By far, the highest recovery of glyoxal was obtained employing one of the in-house DNPH coated silica samplers (93%, RSD = 3.6%, n = 12).
Olsen
Raymond
R
National Institute of Occupational Health, P.O. Box 8149 Dep, N-0033 Oslo, Norway.
Thorud
Syvert
S
Hersson
Merete
M
Ovrebø
Steinar
S
Lundanes
Elsa
E
Greibrokk
Tyge
T
Ellingsen
Dag G
DG
Thomassen
Yngvar
Y
Molander
Paal
P
D000395:Air Pollutants, Occupational / Q000032:analysis*; D004784:Environmental Monitoring / Q000295:instrumentation / Q000379:methods*; D006037:Glyoxal / Q000032:analysis*; D006801:Humans; D016273:Occupational Exposure / Q000032:analysis; D010209:Paper; D017132:Workplace
D000395:Air Pollutants, Occupational; D006037:Glyoxal