title: Cytotoxic constituents from angelicae sinensis radix.
abstract: Cytotoxic bioassay-guided fractionation of methanol extract of Angelicae Sinensis Radix led to the isolation of a new dimeric Z-ligustilide, named neodiligustilide (1), together with three known compounds, Z-ligustilide (2), 11(S),16(R)-dihydroxy-octadeca-9Z, 17-dien-12,14-diyn-1-yl acetate (3), and 3(R),8(S)-falcarindiol (4). Among them, 2 showed the strongest cytotoxicity against L1210 and K562 cell lines with IC50 values of 2.27 +/- 0.10 and 4.78 +/- 0.18 microM, respectively, while 1 showed moderate cytotoxicity with IC50 values of 5.45 +/- 0.19 and 9.87 +/- 0.14 microM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 +/- 0.90 and 2.87 +/- 0.49 microM, respectively.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
authors.forename: Quan Cheng
authors.initials: QC
authors.lastname: Chen
authors.forename: JongPill
authors.initials: J
authors.lastname: Lee
authors.forename: WenYi
authors.initials: W
authors.lastname: Jin
authors.forename: UiJoung
authors.initials: U
authors.lastname: Youn
authors.forename: HongJin
authors.initials: H
authors.lastname: Kim
authors.forename: Ik Soo
authors.initials: IS
authors.lastname: Lee
authors.forename: XinFeng
authors.initials: X
authors.lastname: Zhang
authors.forename: KyungSik
authors.initials: K
authors.lastname: Song
authors.forename: YeonHee
authors.initials: Y
authors.lastname: Seong
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
mesh_terms: D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D007939:Leukemia L1210; D051379:Mice
chemical_list: D000972:Antineoplastic Agents, Phytogenic