Lack of association between Chlamydophila pneumoniae seropositivity and abdominal aortic aneurysm.
Chronic Chlamydophila pneumoniae infection has been suggested as a possible contributing factor for the development and expansion of abdominal aortic aneurysm (AAA). The relevance of C pneumoniae involved in the processes underlying aneurysmal rupture is unknown. The aim of this study was to examine the relationship between C pneumoniae seropositivity and AAA rupture. In a case-control study, 119 patients with AAA and 36 matched controls were prospectively investigated with C pneumoniae serology. Patients with ruptured AAA have similar levels of IgG antibodies against C pneumoniae as patients with an electively operated AAA, a small AAA, and controls. In conclusion, this study fails to demonstrate a connection between C pneumoniae seropositivity and AAA rupture.
Nyberg
Anders
A
Department of Clinical Bacteriology, University of Lund, Lund, Sweden.
Skagius
Elisabet
E
Nilsson
Ingrid
I
Ljungh
Asa
A
Henriksson
Anders E
AE
D000368:Aged; D017542:Aneurysm, Ruptured; D017544:Aortic Aneurysm, Abdominal / Q000382:microbiology*; D016022:Case-Control Studies; D023521:Chlamydophila Infections / Q000097:blood*; D016993:Chlamydophila pneumoniae; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies