title: Low-dose oral methotrexate for the management of childhood Cogan's syndrome: a case report.
abstract: Cogan's syndrome is a rare inflammatory disease characterized by nonsyphilitic ocular interstitial keratitis associated with hearing loss and vestibular impairment. Although systemic corticosteroids are usually used as the standard therapy, hearing ability in most cases gradually deteriorates. We, herein, describe a patient with childhood Cogan's syndrome who was treated with low-dose oral methotrexate, which successfully helped to taper the doses of the systemic corticosteroids. The serum levels of the complements were good markers for the disease activity in this patient.
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan. yuzaburo@graduate.chiba-u.jp.
authors.forename: Yuzaburo
authors.initials: Y
authors.lastname: Inoue
authors.affiliation: Department of Otorhinolaryngology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Tomemori
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan.
authors.forename: Takayasu
authors.initials: T
authors.lastname: Arima
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan.
authors.forename: Minako
authors.initials: M
authors.lastname: Tomiita
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Shimojo
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuou-ku, Chiba city, Chiba, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kohno
mesh_terms: D000284:Administration, Oral; D002648:Child; D018450:Disease Progression; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007634:Keratitis / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D013577:Syndrome
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate