Efficient synthesis of the 3-benzazepine framework via intramolecular Heck reductive cyclization.
A microwave-assisted protocol based on reductive Heck reaction was developed for regio- and stereoselective construction of the 3-benzazepine core.
Donets
Pavel A
PA
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
Van der Eycken
Erik V
EV
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001552:Benzazepines / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D008872:Microwaves; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000470:Alkaloids; D001552:Benzazepines