title: Physical activity, Cdx-2 genotype, and BMD.
abstract: The present study investigated the interaction between Cdx-2 polymorphism and physical activity level over bone mineral density (BMD) variation in Brazilian postmenopausal women. One hundred and ninety women volunteered to participate in the study (66.6 +/- 5.3 years, 64.58 +/- 11.74 kg and 151.94 +/- 6.36 cm). Physical activity level (PAL) was assessed using the international physical activity questionnaire (IPAQ). Lumbar spine (L2 - L4), femoral neck, great trochanter and Wards' triangle bone mineral density (BMD) were measured by dual-energy X-ray absorptiometry (DXA). The Cdx-2 polymorphism was genotyped by minisequencing, using the SNaPshottrade mark Multiplex System (Applied Biosystems, Foster City, CA, USA). Overall, no significant association was found between Cdx-2 polymorphism and adjusted BMD at any site. However, the results revealed a significant interaction between PAL and Cdx-2 genotype on adjusted femoral neck and Wards' triangle BMD. Active women carrying the Cdx-G/G genotype showed higher adjusted femoral neck and Wards' triangle BMD than inactive women carrying the same genotype, thus suggesting a larger chronic response to physical activity. These results suggest that, in postmenopausal women, the Cdx-2 polymorphism does not influence BMD by itself; however, it seems to affect the BMD response to physical activity since only the Cdx-G/G genotype carriers presented significant differences between active and inactive.
authors.affiliation: Programa de Pós Graduação em Educação Física, Universidade Católica de Brasília, Taguatinga, Brazil. paulogentil@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: Gentil
authors.forename: R M
authors.initials: RM
authors.lastname: Lima
authors.forename: T C L
authors.initials: TC
authors.lastname: Lins
authors.forename: B S
authors.initials: BS
authors.lastname: Abreu
authors.forename: R W
authors.initials: RW
authors.lastname: Pereira
authors.forename: R J
authors.initials: RJ
authors.lastname: Oliveira
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000704:Analysis of Variance; D015519:Bone Density / Q000235:genetics*; D001938:Brazil; D000071616:CDX2 Transcription Factor; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D011110:Polymorphism, Genetic; D017698:Postmenopause; D011795:Surveys and Questionnaires; D015534:Trans-Activators / Q000235:genetics*
chemical_list: D000071616:CDX2 Transcription Factor; D018398:Homeodomain Proteins; D015534:Trans-Activators