Origin of ganglioside complex antibodies in Guillain-Barré syndrome.
The origin of antibodies to ganglioside complexes, as new immunotargets for Guillain-Barré syndrome (GBS), is unknown. This was investigated in 21 GBS patients from which Campylobacter jejuni was isolated. Two of these patients had serum IgG to the GM1/GD1a complex and two other patients had IgG to the GQ1b/GD1a complex. These pairs of patients were clinically distinct. These antibodies all cross-reacted to lipo-oligosaccharides (LOS) from the autologous C. jejuni strain. Previous mass spectrometry studies on these LOS showed the presence of oligosaccharides with a similar structure, further supporting the hypothesis that in these patients LOS induced the ganglioside complex antibodies.
Kuijf
Mark L
ML
Department of Neurology, Erasmus MC, 's-Gravendijkwal 230, Rotterdam, The Netherlands. m.kuijf@erasmusmc.nl <m.kuijf@erasmusmc.nl>
Godschalk
Peggy C R
PC
Gilbert
Michel
M
Endtz
Hubert P
HP
Tio-Gillen
Anne P
AP
Ang
C Wim
CW
van Doorn
Pieter A
PA
Jacobs
Bart C
BC
D000328:Adult; D000906:Antibodies / Q000097:blood*; D016123:Campylobacter jejuni / Q000276:immunology* / Q000378:metabolism; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged
D000906:Antibodies; D005732:Gangliosides