Synthesis of functionalized pyrroles via gold(I)-catalyzed aza-Claisen-type rearrangement.
Gold(I)-catalyzed cyclization of pentenynyl allyl tosylamides allows the rapid construction of functionalized pyrroles. The concerted aza-Claisen-type mechanism induces a complete selectivity of the process and allows the easy formation of quaternary centers.
Istrate
Florin M
FM
Laboratoire de Synthèse Organique, UMR 7652 CNRS/Ecole Polytechnique, Ecole Polytechnique, 91128 Palaiseau, France.
Gagosz
Fabien
F
D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis*
D001372:Aza Compounds; D011758:Pyrroles; D006046:Gold