Ligation site in proteins recognized in silico.
Recognition of a ligation site in a protein molecule is important for identifying its biological activity. The model for in silico recognition of ligation sites in proteins is presented. The idealized hydrophobic core stabilizing protein structure is represented by a three-dimensional Gaussian function. The experimentally observed distribution of hydrophobicity compared with the theoretical distribution reveals differences. The area of high differences indicates the ligation site.


BACKGROUND
http://bioinformatics.cm-uj.krakow.pl/activesite.
Brylinski
Michal
M
Department of Bioinformatics and Telemedicine, Collegium Medicum - Jagiellonian University, Kopernika 17, 31-501 Krakow, Poland.
Konieczny
Leszek
L
Roterman
Irena
I