title: Sesquiterpenes from the wood of Juniperus lucayana.
abstract: Bioassay-guided fractionation of ethanolic extract from the wood of Juniperus lucayana afforded three sesquiterpenes named 3-hydroxypseudowiddran-6(7)-en-4-ol (1), 15-hydroxyallo-cedrol (2) and 12-hydroxywiddrol (3) together with six known sesquiterpenes (4-9) and two known flavonoids (10 and 11). Their structures were established on the basis of comprehensive spectroscopic analyses, including 2D NMR spectroscopy and mass spectrometry. The structures of compounds were identified as 1alpha,4beta,11alpha,11beta-tetramethylbicyclo[5,4,0]undec-6(7)-en-3alpha, 4alpha-diol (1), 4beta-hydroxymethyl-5,5,9beta-trimethyltricyclo[4.3.0.2(1.4)]undecan-3alpha-ol (2) and 4beta-hydroxymethyl-7alpha,11alpha,11beta-trimethylbicyclo [5.4.0]undec-1-en-4alpha-ol (3). The major compounds isolated were evaluated for their antifungal activity against Botrytis cinerea. Widdrol (7) was the most active, reaching the 71% inhibition level on mycelial growth after 6 days.
authors.affiliation: Instituto de Investigaciones Fundamentales en Agricultura Tropical Alejandro de Humboldt (INIFAT), Calle:2, Esq.1, Santiago de las Vegas, CP 17200, Cuba.
authors.forename: Yarelis Ortíz
authors.initials: YO
authors.lastname: Nuñez
authors.forename: Iraida Spengler
authors.initials: IS
authors.lastname: Salabarria
authors.forename: Isidro G
authors.initials: IG
authors.lastname: Collado
authors.forename: Rosario
authors.initials: R
authors.lastname: Hernández-Galán
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D018653:Juniperus / Q000737:chemistry*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis / Q000379:methods; D014934:Wood / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D012717:Sesquiterpenes