Morphological detection of hormone and growth factor receptors in breast cancer.
In the multidisciplinary effort of today's clinical oncology, histopathology has to deal increasingly with the genetic and proteomic profiles of neoplastic cells obtained in ever smaller samples via various diagnostic routes. None of the numerous molecular markers available has surpassed hormone and growth factor receptors in their relevance for the selection of targeted therapies. In the following, morphologic concepts and histopathologic methods pertinent to the clinically most important receptors are discussed with a focus on tumors of the breast.
Kölble
Konrad
K
Centrum 5 für Diagnostiche und Präventive Labormedizin, Institut für Pathologie, Berlin, Germany.
D001943:Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis*; D017978:Receptors, Growth Factor / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*
D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D017978:Receptors, Growth Factor; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human