[The use of recombinant factor VIIa on the therapy of massive bleeding after cesarean section].
OBJECTIVE
To present a case report of severe post-partum bleeding after caesarean section and successful treatment using recombinant factor VIIa.


METHODS
Obstetrics and Gynecology Department, Faculty Hospital, Nitra, Slovak Republic.


METHODS
A 29-year old secundigravida presented with major post-partum bleeding after caesarean section due to uterine atony. The patient developed hemorrhagic shock, associated with disseminated intravascular coagulation (DIC). Treatment with uterotonic drugs, prostaglandins and hysterectomy failed to control diffuse bleeding. Recombinant factor VIIa (90 microg/kg intravenous injection) was given as a final attempt to control the bleeding. The response to treatment was rapid, with control of the bleeding and resolution of the coagulopathy.


CONCLUSIONS
This case suggests a potential role of recombination factor VIIa in the treatment of severe post-partum bleeding associated with DIC.
Uharcek
P
P
Gynekologicko-pôrodnícka klinika, Fakultná nemocnice Nitra. uharcek@gmx.net
Mlyncek
M
M
Kellner
M
M
Lajtman
E
E
D000328:Adult; D002585:Cesarean Section / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000188:drug therapy; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000188:drug therapy*; D011247:Pregnancy; D011994:Recombinant Proteins / Q000627:therapeutic use; D012771:Shock, Hemorrhagic / Q000209:etiology
D011994:Recombinant Proteins; D015942:Factor VIIa