Gamma-glutamyltransferase, redox regulation and cancer drug resistance.
Gamma-glutamyltransferase, a key enzyme of GSH metabolism, can modulate crucial redox-sensitive functions, such as antioxidant/antitoxic defences and cellular proliferative/apoptotic balance, with potential implications in tumour progression and drug resistance. Recent studies have elucidated the mechanisms of GGT involvement in various pathological processes suggesting its potential role as therapeutic target and diagnostic/prognostic marker.
Pompella
Alfonso
A
Dipartimento di Patologia Sperimentale, Università di Pisa, Scuola MedicaVia Roma 55, 56126 Pisa, Italy.
Corti
Alessandro
A
Paolicchi
Aldo
A
Giommarelli
Chiara
C
Zunino
Franco
F
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016503:Drug Delivery Systems; D019008:Drug Resistance, Neoplasm; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D010084:Oxidation-Reduction; D011379:Prognosis; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D000970:Antineoplastic Agents; D005723:gamma-Glutamyltransferase; D005978:Glutathione