title: A novel series of potent cytotoxic agents targeting G2/M phase of the cell cycle and demonstrating cell killing by apoptosis in human breast cancer cells.
abstract: Breast cancer, a leading cause of mortality in women, warrants the development and biological evaluation of new anticancer agents. A novel series of thiopyridine triazine derivatives was synthesized and investigated in the human breast cancer cell line, MDA-MB-468. SM40, the most potent derivative, induced a G2/M arrest and apoptosis with a possible involvement of p53. The cytotoxicity of SM40 was also examined against the NCI 60 cell line panel and its potency was rationalized using molecular modeling. Results suggest that SM40 is a promising cytotoxic agent.
authors.affiliation: Faculty of Medicine, Memorial University of Newfoundland, St John's, NL, Canada.
authors.forename: Soma
authors.initials: S
authors.lastname: Mandal
authors.forename: Gervais
authors.initials: G
authors.lastname: Bérubé
authors.forename: Eric
authors.initials: E
authors.lastname: Asselin
authors.forename: Iqbal
authors.initials: I
authors.lastname: Mohammad
authors.forename: Vernon J
authors.initials: VJ
authors.lastname: Richardson
authors.forename: Atul
authors.initials: A
authors.lastname: Gupta
authors.forename: Saroj K
authors.initials: SK
authors.lastname: Pramanik
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Williams
authors.forename: Sanat K
authors.initials: SK
authors.lastname: Mandal
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D001943:Breast Neoplasms / Q000188:drug therapy*; D002455:Cell Division; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D016195:G2 Phase; D006801:Humans; D006860:Hydrogen Bonding; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry; D014227:Triazines / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D011725:Pyridines; D014227:Triazines