Decrease in activity of the serotoninergic system during mutagenesis.
We studied changes in the content of serotonin-modulated anticonsolidation protein in the liver of goldfishes and gobies caused by oil and industrial pollution. The concentration of serotonin-modulated anticonsolidation protein in fish liver increased after short-term exposure to oil-contaminated water (100 mg/liter), but decreased under long-term effect of industrial wastes. We hypothesize that serotonin plays a role in antimutagenic protection of the organism and maintains the differentiated state of mature cells.
Mekhtiev
A A
AA
A. I. Karaev Institute of Physiology, Azerbaijani Academy of Sciences, Baku. arifm@iphysiol.azeri.com
Gaisina
A A
AA
Palatnikov
G M
GM
Kasimov
R Yu
RY
D000818:Animals; D006054:Goldfish / Q000235:genetics* / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D016296:Mutagenesis; D010578:Petroleum / Q000633:toxicity*; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D010578:Petroleum; D014874:Water Pollutants, Chemical; D012701:Serotonin