title: Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.
abstract: The design, synthesis, and in vitro activity of a series of novel 5-ethynyl-2-aryloxybenzylamine-based histamine H(3) ligands that are also serotonin reuptake transporters is described.
authors.affiliation: Johnson & Johnson Pharmaceutical Research & Development LLC, 3210 Merryfield Row, San Diego, CA 92121, USA. mletavic@prdus.jnj.com
authors.forename: Michael A
authors.initials: MA
authors.lastname: Letavic
authors.forename: Emily M
authors.initials: EM
authors.lastname: Stocking
authors.forename: Ann J
authors.initials: AJ
authors.lastname: Barbier
authors.forename: Pascal
authors.initials: P
authors.lastname: Bonaventure
authors.forename: Jamin D
authors.initials: JD
authors.lastname: Boggs
authors.forename: Brian
authors.initials: B
authors.lastname: Lord
authors.forename: Kirsten L
authors.initials: KL
authors.lastname: Miller
authors.forename: Sandy J
authors.initials: SJ
authors.lastname: Wilson
authors.forename: Nicholas I
authors.initials: NI
authors.lastname: Carruthers
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001596:Benzylamines / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D006633:Histamine Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008956:Models, Chemical; D011485:Protein Binding; D051381:Rats; D018100:Receptors, Histamine H3 / Q000737:chemistry*; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D001596:Benzylamines; D006633:Histamine Antagonists; D018100:Receptors, Histamine H3; D017367:Selective Serotonin Reuptake Inhibitors