[The role of exogenous and epidemiological factors in etiology of squamous cell carcinoma of the head and neck in young adults].
Squamous cell carcinoma of the head and neck (HNSCC) is the malignant tumor arising most frequently in non-keratinized epithelial tissue of the upper part of the respiratory or gastrointestinal tracts. These tumors develop most commonly in the sixth or seventh decade of life and significantly less frequently in patients younger than 45 years defined as young adults. In literature, there are still many controversies concerning the origin of these tumors in this group of patients.


OBJECTIVE
To estimate the role of exogenous and epidemiological factors in etiology of HNSCC in young adults.


METHODS
The study group consisted of 95 young adults (< or =< 45 years) with HNSCC and the control group of 95 older patients (> 45 years) with HNSCC, who were treated in the Department of Otolaryngology and Laryngological Oncology of Karol Marcinkowski University of Medical Sciences in Poznan during the period 2000-2004. The analysis was based on etiological questionnaires and the medical records of patients.


CONCLUSIONS
1. A significant role of typical exogenous factors (active and passive exposure to tobacco smoke and alcohol abuse) was established in the etiology of HNSCC in young adults. 2. Daily active exposure to tobacco smoke in young adults is nearly the same as in older patients, but daily passive exposure is higher than in older patients. 3. Significantly higher alcohol consumption in young adults than in older patients, found in this study, may be one of the reasons of HNSCC onset in young age. 4. Occupational exposure to the HNSCC causative factors in young adults is not higher than in older patients. 5. A frequency of familial cancer in young adults with HNSCC seems to be higher than in older patients, but further observations are needed.
Gawecki
Wojciech
W
Klinika Otolaryngologii i Onkologii Laryngologicznej AM im. Karola Marcinkowskiego w Poznaniu.
Szyfter
Krzysztof
K
Szyfter
Witold
W
D000328:Adult; D017668:Age of Onset; D000428:Alcohol Drinking / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D015897:Comorbidity; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000473:pathology; D009367:Neoplasm Staging; D010614:Pharynx / Q000473:pathology; D012189:Retrospective Studies; D012959:Socioeconomic Factors; D014029:Tobacco Use Disorder / Q000453:epidemiology