Hypoglycemic effects of Ganoderma applanatum and Collybia confluens exo-polymers in streptozotocin-induced diabetic rats.
The hypoglycemic effects of Ganoderma applanatum exo-polymer (GAE) and Collybia confluens exo-polymer (CCE) produced by submerged mycelial cultures in streptozotocin (STZ)-induced diabetic rats were investigated. Hypoglycemic effects were achieved in both the GAE- and CCE-treated groups by administration at a level of 100 mg/kg body weight (BW) daily for 3 weeks. The administration of GAE and CCE substantially reduced the plasma glucose levels by as much as 22.0% and 25.9%, respectively, when compared with the control group. The GAE and CCE also lowered the plasma total cholesterol and triglyceride levels by 20.3% and 22.5%, and by 22.7% and 25.5%, respectively. Furthermore, the activity of alanine transaminase (ALT) and aspartate transaminase (AST) was decreased by 23.2% and 20.7% in the GAE-treated group, and it was also reduced by 28.7% and 23.6% in the CCE-treated group. The results strongly demonstrate the potential of GAE and CCE in combating diabetes in experimental animals.
Yang
Byung-Keun
BK
Research Center for Processing and Application of Agricultural Products, Daegu University, Gyungsan, Gyungbuk 712-714, South Korea.
Jung
Yu-Sun
YS
Song
Chi-Hyun
CH
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D001704:Biopolymers / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology; D004435:Eating / Q000187:drug effects; D032902:Ganoderma / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008518:Medicine, East Asian Traditional; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000187:drug effects
D001704:Biopolymers; D007004:Hypoglycemic Agents