Chaperoning the Cln3 cyclin prevents promiscuous activation of start.
In a recent issue of Molecular Cell, Vergés et al. (2007) described a new mechanism of cell-cycle control. Nuclear translocation of the G1 cyclin Cln3 is prevented by its retention at the endoplasmic reticulum (ER), and its release requires growth-associated increases in chaperone activity.
Lowndes
Noel F
NF
Genome Stability Laboratory, Department of Biochemistry, National University of Ireland, Galway, University Road, Galway, Ireland. noel.lowndes@nuigalway.ie
D002453:Cell Cycle; D016213:Cyclins / Q000378:metabolism*; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
C079895:CLN3 protein, S cerevisiae; D016213:Cyclins; D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins