[Onconeural antibodies as a tool for diagnosis of malignant tumors and paraneoplastic neurological disorders].
Paraneoplastic neurological syndromes (PNS) are autoimmune neurodegenerative diseases that develop as a result of the cross-reactivity of the tumor-specific immune effectors with neurons of central and peripheral nervous systems. So-called onconeural antibodies, which are detected in sera of PNS patients, are not only crucial diagnostic markers of PNS and associated tumors, but also have a considerable potential in the serological diagnosis of cancer as a whole. In this review we discuss the role of onconeural antibodies in serological diagnosis of PNS and associated tumors as well as their potential in diagnosis and prognostication of a broad spectrum of malignant tumors.
Belousov
P V
PV
Shebzukhov
Iu V
IuV
Nedospasov
S A
SA
Kuprash
D V
DV
D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology*; D020274:Autoimmune Diseases of the Nervous System / Q000175:diagnosis* / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis* / Q000276:immunology*; D010525:Peripheral Nerves / Q000276:immunology / Q000473:pathology; D011379:Prognosis
D000912:Antibodies, Neoplasm