title: Dietary intake, neutrophil fatty acid profile, serum antioxidant vitamins and oxygen radical absorbance capacity in patients with ulcerative colitis.
abstract: Nutrition may play an important role in the pathogenesis and treatment of ulcerative colitis. Several studies suggest an association between dietary factors and the onset of ulcerative colitis; however, only few studies have examined the relationship between dietary intake and relapse of ulcerative colitis. The aim of this study was to assess the dietary intake and antioxidative capacity of ulcerative colitis patients and to elucidate the efficacy of dietary therapy for ulcerative colitis. Dietary intake, fatty acid composition of phospholipids in plasma and neutrophils, serum fat-soluble vitamin levels, and oxygen radical absorbance capacity were analyzed in 29 ulcerative colitis patients (7 males and 22 females), who were treated at the Department of Gastroenterology, Okayama University Hospital. Total fat intake, fat energy ratio and linoleic acid intake were significantly lower, while protein and carbohydrate intakes were significantly higher, in the patients than age- and sex-matched controls. In the neutrophil phospholipids of ulcerative colitis patients, significantly higher levels of linoleic aicd and arachidonic acid and a lower level of eicosapentaenoic acid were observed. The concentrations of serum retinol and beta-carotene but not alpha-tocopherol were significantly lower and serum oxygen radical absorbance capacity was also lower than in the controls. Significant correlations between serum oxygen radical absorbance capacity and retinol (r = 0.567, p = 0.0031), alpha-tocopherol (r = 0.560, p = 0.0036) and beta-carotene (r = 0.440, p = 0.0279) concentrations were observed in the ulcerative colitis patients. A diet restricting the intake of linoleic acid and supplemented with eicosapentaenoic acid and antioxidative vitamins may be recommendable for the nutritional management of ulcerative colitis patients.
authors.affiliation: Department of Human Nutrition, Chugokugakuen University, Okayama 701-0197, Japan. kyuko@cjc.ac.jp
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Murakami
authors.forename: Takayo
authors.initials: T
authors.lastname: Kawakami
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ueda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kunii
authors.forename: Yachiyo
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shiratori
authors.forename: Misako
authors.initials: M
authors.lastname: Okita
mesh_terms: D000328:Adult; D000418:Albumins / Q000378:metabolism; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000378:metabolism*; D004032:Diet / Q000379:methods*; D015930:Diet Records; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014801:Vitamin A / Q000097:blood; D014815:Vitamins / Q000097:blood*; D024502:alpha-Tocopherol / Q000097:blood; D019207:beta Carotene / Q000097:blood
chemical_list: D000418:Albumins; D000975:Antioxidants; D005227:Fatty Acids; D010743:Phospholipids; D011506:Proteins; D017382:Reactive Oxygen Species; D014815:Vitamins; D019207:beta Carotene; D014801:Vitamin A; D024502:alpha-Tocopherol