A strategy for the synthesis of 2,3-disubstituted indoles starting from N-(o-halophenyl)allenamides.
A strategy for the synthesis of 2,3-disubstituted indole derivatives based on an intramolecular carbopalladation-anion capture cascade has been developed, wherein construction of the pyrrole ring and functionalisation of the indole C2 and C3 positions were achieved by extensive use of palladium(0)-catalysed coupling reactions.
Fuwa
Haruhiko
H
Laboratory of Biostructural Chemistry, Graduate School of Life Sciences, Tohoku University, 1-1 Tsutsumidori-amamiya, Sendai 981-8555, Japan. hfuwa@bios.tohoku.ac.jp
Sasaki
Makoto
M
D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
D007211:Indoles; D010165:Palladium