Importance of 5-hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity.
Serotonin (5-HT) plays an important role as a signalling molecule in the gastrointestinal (GI) tract. The regulation of GI sensitivity via 5-HT is mediated by specific 5-HT receptor subytypes on intrinsic and extrinsic afferents. This review discusses visceral afferent hypersensitivity in irritable bowel syndrome (IBS) and the importance of 5HT(3), 5HT(4), and 5HT(2B) receptor-mediated mechanisms in the regulation of visceral sensitivity.
Greenwood-van Meerveld
B
B
Veteran's Affairs Medical Center and Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA. beverley-greenwood@ouhsc.edu
D000818:Animals; D017615:Enteric Nervous System / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000294:innervation*; D043183:Irritable Bowel Syndrome / Q000503:physiopathology; D020033:Protein Isoforms / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D017833:Visceral Afferents / Q000378:metabolism*
D020033:Protein Isoforms; D011985:Receptors, Serotonin; D012701:Serotonin