The role of aldosterone and mineralocorticoid receptors in cardiovascular disease.
The roles of aldosterone and mineralocorticoid receptors in cardiovascular disease have been expanded, refined, and distinguished over the past decade. Primary aldosteronism has been shown to represent 8-13% (rather than <1%) of unselected hypertensive patients, and patients with primary aldosteronism to have higher indices of cardiovascular damage than controls of the same age, sex, and BP status. While this represents a clearly expanded role for aldosterone, it is improbable that the hormone (as opposed to the mineralocorticoid receptor) plays a major role in other instances of essential hypertension, in cardiac failure, or in atherosclerosis. Evidence from studies in these conditions supports a substantial role for mineralocorticoid receptor activation; low baseline aldosterone levels, and evidence from experimental in vivo studies, support a role for normal levels of physiologic glucocorticoids in activating mineralocorticoid receptors (MR) in the context of tissue damage and reactive oxygen species generation. These relatively recent insights suggest the potential therapeutic role for MR antagonists across a spectrum of cardiovascular disease, as vascular protectants even when circulating levels of aldosterone are low.
Funder
John W
JW
Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia. john.funder@princehenrys.org
D000450:Aldosterone / Q000502:physiology; D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000378:metabolism; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D000451:Mineralocorticoid Receptor Antagonists; D018161:Receptors, Mineralocorticoid / Q000502:physiology*
D000451:Mineralocorticoid Receptor Antagonists; D018161:Receptors, Mineralocorticoid; D000450:Aldosterone