A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex.
Targeted gene inactivation and metabolic profiling revealed that the cryptic PKS-NRPS gene cluster in the genome of the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of antiproliferative and antifungal rhizoxin derivatives.
Brendel
Nicole
N
Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11 a, D-07745 Jena, Germany.
Partida-Martinez
Laila P
LP
Scherlach
Kirstin
K
Hertweck
Christian
C
D050256:Antimitotic Agents / Q000737:chemistry* / Q000378:metabolism; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D018942:Macrolides / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological; D011551:Pseudomonas fluorescens / Q000235:genetics* / Q000378:metabolism
D050256:Antimitotic Agents; D018942:Macrolides; C041443:rhizoxin