Elucidating the spectrum of alpha-thalassemia mutations in Iran.
Alpha thalassemia (alpha-thal) is one of the most common hemoglobin (Hb) disorders in the world. Alpha-globin genes are located on chromosome 16. The majority of alpha-thal mutations are deletions but point mutations are found as well. Since the Iranian population is a mixture of different ethnic groups, frequency and distribution of alpha-globin mutations in various regions of the country need to be clarified. These findings can contribute to a wider understanding of this disorder.
Hadavi
Valeh
V
Kariminejad-Najmabadi Pathology & Genetics Center, 14665/154, Tehran, Iran.
Taromchi
Amir Hossein
AH
Malekpour
Mahdi
M
Gholami
Behjat
B
Law
Hai-Yang
HY
Almadani
Navid
N
Afroozan
Fariba
F
Sahebjam
Farhad
F
Pajouh
Parisa
P
Kariminejad
Roxana
R
Kariminejad
Mohammad Hassan
MH
Azarkeivan
Azita
A
Jafroodi
Maryam
M
Tamaddoni
Ahmad
A
Puehringer
Helene
H
Oberkanins
Christian
C
Najmabadi
Hossein
H
D005787:Gene Frequency; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D017720:Molecular Epidemiology; D009154:Mutation; D017085:alpha-Thalassemia / Q000453:epidemiology / Q000235:genetics*
D006455:Hemoglobins, Abnormal