title: Three loci on mouse chromosome 5 and 10 modulate sex determination in XX Ods/+ mice.
abstract: In mouse, XY embryos are committed to the male sex determination pathway after the transient expression of the Y-linked Sry gene in the Sertoli cell lineage between 10.5 and 12.5 dpc. In the C57BL/6J strain, male sex determination program can be modulated by some autosomal genes. The C57BL/6J alleles at these autosomal loci can antagonize male sex determination in combination with specific Sry alleles. In this report, the authors have identified an effect of these C57BL/6J specific alleles in combination with a mutated Sox9 allele, Sox9(Ods). Authors report the mapping of three of these genetic loci on mouse chromosome 5 and 10 in a backcross of the Ods mutation to the C57BL/6J background. Our study confirms the importance of the strain C57BL/6J for the investigation of the genetic mechanisms that control sex determination.
authors.forename: Christophe
authors.initials: C
authors.lastname: Poirier
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Moran
authors.forename: Ertug
authors.initials: E
authors.lastname: Kovanci
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Petit
authors.forename: David R
authors.initials: DR
authors.lastname: Beier
authors.forename: Colin E
authors.initials: CE
authors.lastname: Bishop
mesh_terms: D000818:Animals; D005260:Female; D006609:High Mobility Group Proteins / Q000235:genetics; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D055758:SOX9 Transcription Factor; D019849:Sex Determination Processes; D014157:Transcription Factors / Q000235:genetics; D014960:X Chromosome / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics
chemical_list: D006609:High Mobility Group Proteins; D055758:SOX9 Transcription Factor; C527933:Sox9 protein, mouse; D014157:Transcription Factors