title: Platelet-enriched fibrin glue and platelet-rich plasma in the repair of bone defects adjacent to titanium dental implants.
abstract: OBJECTIVE
  The aim of this study was to compare the effects of platelet-enriched fibrin glue and platelet-rich plasma (PRP) on the repair of bone defects adjacent to titanium dental implants.
  
  
  METHODS
  In 6 mongrel dogs, 3 screw-shaped titanium dental implants per dog were placed into the osteotomy sites in the tibia. Before implantation, a standardized gap (2.0 mm) was created between the implant surface and the surrounding bone walls. Six gaps were left empty (control group), 6 gaps were filled with autogenous particulate bone mixed with PRP (PRP group), and 6 gaps were filled with autogenous particulate bone mixed with platelet-enriched fibrin glue (fibrin glue group).
  
  
  RESULTS
  After 6 weeks, the bone-implant contact was 59.7% in the fibrin glue group, 29.2% in the PRP group, and 10.2% in the control defects; this difference was statistically significant (P < .05).
  
  
  CONCLUSIONS
  Greater bone-implant contact was achieved with platelet-enriched fibrin glue than with PRP. The results indicate that platelet-enriched fibrin glue can induce a stronger peri-implant bone reaction than PRP in the treatment of bone defects adjacent to titanium dental implants.
authors.affiliation: Graduate Student, Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Tae-Min
authors.initials: TM
authors.lastname: You
authors.forename: Byung-Ho
authors.initials: BH
authors.lastname: Choi
authors.forename: Shi-Jiang
authors.initials: SJ
authors.lastname: Zhu
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Jung
authors.forename: Seoung-Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Huh
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jingxu
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D015921:Dental Implants; D004285:Dogs; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D053657:Platelet-Rich Plasma; D013977:Tibia / Q000601:surgery; D014945:Wound Healing
chemical_list: D015921:Dental Implants; D015718:Fibrin Tissue Adhesive