Controlled release of preservatives using dealuminated zeolite Y.
This study demonstrates that dealuminated zeolite Y can act as a depot after adsorption of phenol derived preservatives. Upon suspension of zeolite loaded with the preservative m-cresol, equilibrium was quickly reached between free and adsorbed m-cresol. The equilibrium concentration of m-cresol was below 1 mM; however, it was enough to kill bacteria such as Escherichia coli and Staphylococcus aureus under metabolically active conditions. Killing of bacteria was not obtained under non-proliferating conditions and m-cresol was only released from the zeolite upon bacterial activity. Together, these results demonstrate an interesting potential use of dealuminated zeolite Y containing adsorbed preservatives for preventing microbial growth in numerous applications in industry and clinical setting.
Eriksson
Håkan
H
Health and Society, Malmö University, S-20506 Malmö, Sweden. hakan.eriksson@hs.mah.se
D000327:Adsorption; D000535:Aluminum / Q000737:chemistry / Q000302:isolation & purification; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D001548:Benzalkonium Compounds / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D050296:Microbial Viability / Q000187:drug effects; D019800:Phenol / Q000737:chemistry; D011310:Preservatives, Pharmaceutical / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D017641:Zeolites / Q000737:chemistry* / Q000494:pharmacology
D000890:Anti-Infective Agents; D001548:Benzalkonium Compounds; D011310:Preservatives, Pharmaceutical; D017641:Zeolites; D019800:Phenol; D000535:Aluminum