[Estimation of activity of pharmakopeal disinfectants and antiseptics against Gram-negative and Gram-positive bacteria isolated from clinical specimens, drugs and environment].
The MIC of nine different disinfectants and antiseptics were determined for the Gram-negative and Gram-positive bacteria. Strains originated from clinical specimens, drugs and environment. A sensitivity was determined against chlorhexidinum digluconate (Gram-negative: 0,625-80 mg/L, Gram-positive: 0,3-10 mg/L), benzalconium chloride (Gram-negative: 2,5-1280 mg/L, Gram-positive: 1,25-20 mg/L), salicilic acid (Gram-negative and Gram-positive: 400-1600 mg/L), benzoic acid (Gram-negative: 800-1600 mg/L, Gram-positive: 400-1 600 mg/L), boric acid (Gram-negative: 800-12 800 mg/L, Gram-positive: 1 600-6400 mg/L), chloramine B (Gram-negative: 1600-6400 mg/L, Gram-positive:800- 6400 mg/L), jodine (Gram-negative: 200-1600 mg/L, Gram-positive: 200-1600 mg/L), etacridine lactate (Gram-negative: 40 do > 20480 mg/L, Gram-positive: 40-1280 mg/L) and resorcine (Gram-negative: 1600-6400 mg/L, Gram-positive: 800-6400 mg/L). Diversified values of MIC for different strains were obtained, especially in the case of benzalconium chloride, etacridine lactate, chlorhexidinum digluconate, boric acid and iodine. Strains isolated from environment were usually more susceptible to examined compounds than clinical strains. The biggest diversification of sensitivity was observed among strains originated from drugs where besides sensitive appeared strains characterizing by very high MIC values of some substances, eg. boric acid.
Grzybowska
Wanda
W
Zakład Antybiotyków i Mikrobiologii Narodowego Instytutu Zdrowia Publicznego w Warszawie.
Młynarczyk
Grazyna
G
Młynarczyk
Andrzej
A
Bocian
Ewa
E
Luczak
Mirosław
M
Tyski
Stefan
S
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology; D019817:Benzoic Acid / Q000494:pharmacology; D001888:Boric Acids / Q000494:pharmacology; D002700:Chloramines / Q000494:pharmacology; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D004203:Disinfection / Q000379:methods; D004783:Environmental Microbiology; D004784:Environmental Monitoring / Q000379:methods*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006272:Health Facility Environment; D007455:Iodine / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000382:microbiology; D012118:Resorcinols / Q000494:pharmacology; D013045:Species Specificity; D014105:Tosyl Compounds / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D001548:Benzalkonium Compounds; D001888:Boric Acids; D002700:Chloramines; D004202:Disinfectants; D012118:Resorcinols; D014105:Tosyl Compounds; C016300:chloramine-T; D019817:Benzoic Acid; D007455:Iodine; C010882:chlorhexidine gluconate; D002710:Chlorhexidine; C032688:boric acid; C031389:resorcinol