Effect of the combination of organic and inorganic filters on the Sun Protection Factor (SPF) determined by in vitro method.
This paper describes the effect on Sun Protection Factor (SPF) of the combination of inorganic and organic filters in sunscreen products as determined by an in vitro method. O/W emulsions containing inorganic filters, such as titanium dioxide and zinc oxide, combined with 18 EU-authorized UV-B organic filters were tested. SPF measurements were carried out using a spectrophotometer equipped with an integrating sphere. This study observed a synergic effect when titanium dioxide was combined with either anisotriazine or octyldimethylPABA. The combination of zinc oxide with 11 UV-B organic filters also exhibited a similar synergy; however, the measured SPF was systematically lower than the protection factor achieved with titanium dioxide.
El-Boury
S
S
Université de Nantes, Nantes Atlantique Universités, LPiC, SMAB, EA2160, Faculty of Pharmacy, 1 rue G. Veil - BP 53508, Nantes F-44000, France.
Couteau
C
C
Boulande
L
L
Paparis
E
E
Coiffard
L J M
LJ
D010129:4-Aminobenzoic Acid / Q000737:chemistry / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D004339:Drug Compounding; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004357:Drug Synergism; D004655:Emulsions; D004890:Erythema / Q000209:etiology / Q000517:prevention & control; D008956:Models, Chemical; D009821:Oils / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013473:Sunscreening Agents / Q000737:chemistry* / Q000494:pharmacology; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology; D014466:Ultraviolet Rays / Q000009:adverse effects; D014867:Water / Q000737:chemistry; D015034:Zinc Oxide / Q000737:chemistry* / Q000494:pharmacology; D062366:para-Aminobenzoates
D004338:Drug Combinations; D004655:Emulsions; D009821:Oils; D013473:Sunscreening Agents; D014227:Triazines; D062366:para-Aminobenzoates; D014867:Water; C009495:titanium dioxide; C015402:octyl dimethyl 4-aminobenzoic acid; D019904:Polymethyl Methacrylate; D014025:Titanium; D015034:Zinc Oxide; D010129:4-Aminobenzoic Acid