Effects of chitosan and heparin on early extension of burns.
Chitosan, a naturally occurring high-molecular glycosaminoglycan (GAG), has been widely used in wound healing, including burns. Heparin is also a highly used glycosaminoglycan in burns. To evaluate the effects of chitosan and heparin alone and the mixture of chitosan and heparin on early extension of burn wound, deep partial-thickness burns were performed on the dorsum of rats. Then chitosan and heparin powder and the mixture of chitosan and heparin were applied, respectively, on the burn wounds. After 72 h, histological examination of the burn wounds was performed. Outcome showed that the burn degree of chitosan group was less severe than control group and chitosan greatly prevented the extension of burns in early phase. However, heparin had no protective effect on the early extension of burns. Use of chitosan and heparin together attenuated chitosan's protective effect.
Jin
Yan
Y
School of Pharmacy, Shandong University, Jinan 250012, China.
Ling
Pei-Xue
PX
He
Yan-Li
YL
Zhang
Tian-Min
TM
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D048271:Chitosan / Q000627:therapeutic use*; D018450:Disease Progression; D004359:Drug Therapy, Combination; D006493:Heparin / Q000627:therapeutic use*; D008297:Male; D020556:Neutrophil Infiltration / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D015599:Trauma Severity Indices
D001672:Biocompatible Materials; D006493:Heparin; D048271:Chitosan