A new flavonoid glycoside from the leaf of Cephalotaxus koreana.
A new flavone glycoside, apigenin 5-O-alpha-L-rhamnopyranosyl-(1-->3)-beta-D-glucopyranoside (1), along with four known flavonol glycosides (2-5), were isolated from the leaf of Cephalotaxus koreana. The new glycoside 1 showed inhibitory activity in superoxide radical scavenging assay with IC(50) value of 13.0 microM, while it showed weak activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Compounds 2-5 exhibited antioxidant activity in scavenging DPPH and superoxide radicals with IC(50) values ranging from 5.7 to 22.3 microM.
Bae
Kihwan
K
College of Pharmacy, Chungnam National University, Daejeon, South Korea. baekh@cnu.ac.kr
Jin
Wenyi
W
Thuong
Phuong Thien
PT
Min
Byung Sun
BS
Na
Minkyun
M
Lee
Young Mi
YM
Kang
Sam Sik
SS
D001713:Biphenyl Compounds; D032483:Cephalotaxus; D047309:Flavones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006027:Glycosides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D013481:Superoxides / Q000737:chemistry
D001713:Biphenyl Compounds; D047309:Flavones; D016166:Free Radical Scavengers; D006027:Glycosides; D010851:Picrates; D010936:Plant Extracts; D013481:Superoxides; C004931:1,1-diphenyl-2-picrylhydrazyl