title: Undifferentiated perivascular cells in myxoid mesenchymal tumors: an ultrastructural study.
abstract: The current WHO classification of soft tissue tumors is based on the lineage of differentiation of the proliferating cells. Since mature mesenchymal cells have a broad phenotypic plasticity it has been considered unnecessary to recur to a hypothetical stem cell to explain the origin of these neoplasms. In spite of this assumption, the target cell of the oncogenic mutations in mesenchymal tumors is still a controversial item. Myxoid mesenchymal tumors constitute a heterogeneous group of neoplasms sharing in an ample mucinous matrix that separates neoplastic cells and facilitates their single submicroscopic study under electron microscopy examination. The authors have studied, by electron microscopy, 74 myxoid mesenchymal tumors, including a large variety of nosologic entities, to assess their madurational gradient. In 43 of 74 cases, a common element has been found: medium-sized cells, with high nucleo-cytoplasmic ratio, lacking lineage specific features, which were arranged around the capillary vessels. In some cases, the authors were able to demonstrate gradual differentiation in these cells, as they moved away from the vessels. These features support the hypothesis that at least some mesenchymal tumors originate from perivascular undifferentiated cells. In addition, the findings might contribute to define both topographic and morphologic characteristics of adult stem mesenchymal cells.
authors.affiliation: Dto de Anatomía patológica, Hospital 12 de Octubre, Madrid, Spain. mmartinezg.hdoc@salud.madrid.org
authors.forename: Miguel Angel Martínez
authors.initials: MA
authors.lastname: González
authors.forename: Carmen Gonzalez
authors.initials: CG
authors.lastname: Lois
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002196:Capillaries / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008637:Mesenchymoma / Q000098:blood supply / Q000378:metabolism / Q000648:ultrastructure*; D046529:Microscopy, Electron, Transmission; D009093:Mucus / Q000378:metabolism; D020286:Pericytes / Q000648:ultrastructure*; D010524:Peripheral Nervous System Neoplasms / Q000648:ultrastructure; D012983:Soft Tissue Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D014408:Biomarkers, Tumor