title: Albumin-alginate-coated microspheres: resistance to steam sterilization and to lyophilization.
abstract: The paper describes the effect of different thermal treatments on the morphology and binding properties of particles prepared using a transacylation reaction between two biocompatible polymers, namely propylene glycol alginate and human serum albumin. Compared to control alginate gel microspheres, albumin-alginate covalent network offers a better resistance to the microspheres towards freezing, lyophilization and sterilization. The binding properties for methylene blue were not altered by the treatments. Moreover, stability in physiological environments opens interesting applications in biological and pharmaceutical fields.
authors.affiliation: CNRS FRE 2715, Université de Reims-Champagne Ardenne, IFR 53, Faculté de Pharmacie, 51 rue Cognacq-Jay, 51100 Reims, France.
authors.forename: Maïté
authors.initials: M
authors.lastname: Callewaert
authors.forename: Dominique
authors.initials: D
authors.lastname: Laurent-Maquin
authors.forename: Florence
authors.initials: F
authors.lastname: Edwards-Lévy
mesh_terms: D000215:Acylation; D000464:Alginates / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004355:Drug Stability; D005612:Freeze Drying; D005615:Freezing; D006361:Heating; D006801:Humans; D008751:Methylene Blue / Q000737:chemistry; D008863:Microspheres; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry*; D013227:Steam; D013242:Sterilization
chemical_list: D000464:Alginates; D004337:Drug Carriers; D012709:Serum Albumin; D013227:Steam; C038550:propylene glycol alginate ester; D008751:Methylene Blue