A rare occurrence of trisomy 18 and trisomy 21 in a dizygotic twin pregnancy.
OBJECTIVE
Case report of a rare combination of a trisomy 18 and 21 in a dizygotic twin pregnancy in a woman with a history of recurrent miscarriage, a neonatal death, no living offspring and Graves disease.


METHODS
Case report and literature search.


RESULTS
Only one other report in the literature of a combined trisomy 18 and 21 twin pregnancy was found.


CONCLUSIONS
The combination of a trisomy 18 and 21 in a dizygotic twin pregnancy is very rare. Despite the high frequency and clinical importance of aneuploidy, very little is known about the factors that may modulate meiotic non-disjunction.
Pelikan
Harold M P
HM
Department of Obstetrics and Gynaecology, University Hospital Maastricht (AZM), P. O. Box 5800, 6202 AZ Maastricht, The Netherlands. h.pelikan@tiscali.nl
Bijlsma
Emilia K
EK
van Wijngaarden
Willem J
WJ
D000032:Abortion, Therapeutic; D000328:Adult; D002887:Chromosomes, Human, Pair 18; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000175:diagnosis* / Q000196:embryology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014314:Trisomy / Q000175:diagnosis*; D014429:Twins, Dizygotic