Rectal carcinoid tumor with bone marrow and osteoblastic bone metastasis: a case report.
Rectal carcinoids comprise 12.6% of all carcinoid tumors and represent the third largest group of the gut carcinoids. A 64-year-old woman was diagnosed as high-grade neuroendocrine carcinoma. She had liver, bone, and bone marrow metastasis. Carcinoid syndrome was diagnosed due to diarrhea, nausea, vomiting, tachycardia, and high level of 24-hour urinary 5-hydroxyindoleacetic acid (160 mg/24 hours). No response was obtained by octreotide treatment. Rectal carcinoid tumors usually show favorable prognosis; however, poorly differentiated tumors might have unusually aggressive behavior and resistance to treatment. Bone marrow involvement might be a poor prognostic factor in carcinoid tumor as has been the case in many other tumors.
Ozkan
Metin
M
Departments of Medical Oncology, Erciyes University Medical Faculty, Kayseri. metino@erciyes.edu.tr.
Er
Ozlem
O
Karahan
I Okkeş
IO
Deniz
Kemal
K
Coşkun
Ramazan
R
Küçük
Can
C
Yurci
Alper
A
Altinbaş
Mustafa
M
D019046:Bone Marrow Neoplasms / Q000175:diagnosis / Q000556:secondary*; D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary*; D002276:Carcinoid Tumor / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary*; D008303:Malignant Carcinoid Syndrome / Q000209:etiology; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000473:pathology*