Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum.
Lysyl tRNA synthetases facilitate amino acylation and play a crucial role in the essential cellular process of translation. They are grouped into two distinct classes (class I and class II). Class I lysyl tRNA synthetase is considered as a drug target for syphilis caused by Treponema pallidum. Comparative genome analysis shows the absence of its sequence homolog in eukaryotes. The structure of class I lysyl tRNA synthetase from Treponema pallidum is unknown and the difficulties in the in vitro culturing of Treponema makes it non-trivial. We used the structural template of class I lysyl tRNA synthetase from the archaea Pyrococcus horikoshii for modeling the Treponema pallidum lysyl tRNA synthetase structure. Thus, we propose the usefulness of the modeled class I lysyl tRNA synthetase for the design of suitable inhibitors towards the treatment of syphilis.
Rao
Venkata Rao Dodaghatta Krishna
VR
Department of Microbiology, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India.
Ramanjeneyulu
Rallapalli
R
Rao
Dowlathabad Muralidhara
DM
Kumar
Chitta Suresh
CS