title: Intussusception in canine recipients of hematopoietic cell grafts and surgical correction.
abstract: Intussusception is a common complication after canine hematopoietic cell transplantation (HCT). The present study was undertaken to evaluate predisposing factors of intussusception and to test whether intussusception can be managed surgically during the period immediately after HCT. We determined the incidence of intussusception after HCT was performed in 325 canine recipients (autologous, n = 43; allogeneic, n = 282) during the interval from January 2002 to May 2005. Intussusception was diagnosed in 16 of 325 dogs (4.9%). Intussusception was not significantly associated with the dose of irradiation, source of hematopoietic graft, use of immunosuppressive agents, gender, or age at transplant. A group of 9 of the affected dogs underwent small-bowel resection after diagnosis, and 7 were managed without surgical intervention. Despite complicating factors such as gastrointestinal toxicity and low neutrophil and platelet counts induced by the marrow conditioning regimen and the use of immunosuppressive agents, successful surgical management of intussusception was achieved in 6 of 9 dogs, as compared with successful management of 0 of 7 without surgery. Intussusception did not recur after surgical intervention in any dog. Recent HCT and post-transplant immunosuppressive therapy are not absolute contraindications to surgical intervention for intussusception in canine recipients of HCT.
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Murad Y
authors.initials: MY
authors.lastname: Yunusov
authors.forename: Fabio
authors.initials: F
authors.lastname: Kerbauy
authors.forename: Kraig
authors.initials: K
authors.lastname: Abrams
authors.forename: Eustacia
authors.initials: E
authors.lastname: Zellmer
authors.forename: Michele
authors.initials: M
authors.lastname: Spector
authors.forename: Christian S
authors.initials: CS
authors.lastname: Kuhr
authors.forename: Billanna
authors.initials: B
authors.lastname: Hwang
authors.forename: Barry
authors.initials: B
authors.lastname: Storer
authors.forename: George E
authors.initials: GE
authors.lastname: Georges
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Weigler
authors.forename: Rainer
authors.initials: R
authors.lastname: Storb
authors.forename: Richard A
authors.initials: RA
authors.lastname: Nash
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D004285:Dogs; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D007077:Ileal Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery / Q000662:veterinary*; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007443:Intussusception / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery / Q000662:veterinary*; D008297:Male; D012307:Risk Factors; D019172:Transplantation Conditioning / Q000662:veterinary; D014463:Ultrasonography; D014916:Whole-Body Irradiation / Q000662:veterinary
chemical_list: D007166:Immunosuppressive Agents