[Expression of chemokine like factor-1 in nephridial tissue of lupus nephritis].
OBJECTIVE
To investigate the influence of chemokine like factor-1(CKLF-1) on the genesis and development of lupus nephritis.


METHODS
Immunohistochemistry stain was employed on the 34 lupus nephridial tissues and 10 nephridial tissues of control group. And light microscopy was applied to observe the percentage of CKLF-1 positive cells of renal gromerulus and tubule.


RESULTS
The percentages of CKLF-1 positive cells of renal gromerulus and tubule were 10.4%+/-1.5% and 48.9%+/-4.3% in the lupus nephritis group, and the percentages of control group were 4.6%+/-1.1% and 4.3%+/-0.9%. There was significant difference between 2 groups (P<0.01). And there was positive correlation between the percentage of CKLF-1 positive cells of renal gromerulus and tubule and lupus active index (r=0.74 and r=0.53, respectively, P<0.05).


CONCLUSIONS
CKLF-1 plays a role in the genesis and development of lupus nephritis.
Ji
Ying
Y
Department of Nephrology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhang
Hao
H
Yuan
Hong
H
Yang
Guo-ping
GP
Zhang
Ke
K
Xie
Li-hua
LH
D000328:Adult; D018925:Chemokines / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry* / Q000473:pathology; D008181:Lupus Nephritis / Q000378:metabolism* / Q000473:pathology; D062792:MARVEL Domain-Containing Proteins; D008297:Male
C432676:CKLF protein, human; D018925:Chemokines; D062792:MARVEL Domain-Containing Proteins