Molecular biology of cervical cancer.
Cervical cancer is a virus-induced disease that is caused by the integration of high-risk infecting human papillomaviruses (HPV) in the host genome. For this reason, the carcinogenesis process of cervical cancer is associated to the expression of the viral oncogenic proteins E6 and E7. These proteins are capable of inactivating p53 and pRb, which induces a continuous cell proliferation with the increasing risk of accumulation of DNA damage that eventually leads to cancer. Moreover, cervical cancer can be prevented by prophylactic HPV vaccines; their molecular characteristics and mechanism of action are reviewed. Ultimately, new molecular targets for cervical cancer like proteasome, the EGFR family and IGF family are exposed.
González Martín
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Medical Oncology Service, University Hospital Ramón y Cajal, Madrid, Spain. agonzalezm@seom.org
D052685:Alphapapillomavirus / Q000502:physiology; D005260:Female; D006801:Humans; D008967:Molecular Biology; D053918:Papillomavirus Vaccines; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control / Q000821:virology*
D053918:Papillomavirus Vaccines