title: Identification of antioxidant phenolic compounds in feverfew (Tanacetum parthenium) by HPLC-ESI-MS/MS and NMR.
abstract: Antioxidant polyphenolic acids in the medicinal herb feverfew (Tanacetum parthenium) were isolated through in vitro bioassay-orientated antioxidant tests in response to 1,1-diphenyl-2-picrylhydrazyl (DPPH*) free radical scavenging and Fe(2+)-chelating activities. Purification of the active compounds and their structural elucidation involved a variety of techniques including open-column chromatography, HPLC, GC-MS, LC-MS and NMR. Major compounds with potent DPPH* scavenging activities were characterised as 3,5-, 4,5- and 3,4-di-O-caffeoylquinic acids (DCQAs). This is the first report of DCQAs found in feverfew.
authors.affiliation: Department of Food Science and Human Nutrition, Clemson University, Clemson, SC 29634, USA. changqi@clemson.edu
authors.forename: Changqing
authors.initials: C
authors.lastname: Wu
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.forename: Yonnie
authors.initials: Y
authors.lastname: Wu
authors.forename: Meidui
authors.initials: M
authors.lastname: Dong
authors.forename: Guoqing
authors.initials: G
authors.lastname: He
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Galyean
authors.forename: Lilin
authors.initials: L
authors.lastname: He
authors.forename: Guohui
authors.initials: G
authors.lastname: Huang
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D020903:Tanacetum parthenium / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D010636:Phenols