Insulin regulation of phosphoenolpyruvate carboxykinase-c gene transcription: the role of sterol regulatory element-binding protein 1c.
The effect of insulin on the regulation of phosphoenolpyruvate carboxykinase C (PEPCK-C) gene transcription, while pivotal for control of carbohydrate metabolism, constitutes only a small part of its overall action in cellular processes. Transcription of the PEPCK-C gene is the target for a number of pathways involved in the signal transduction initiated by insulin, and these processes involve an array of transcription factors and co-regulatory proteins that either alone or in concert bind to a subset of sites in the gene promoter to regulate its expression. This review will focus on a specific transcription factor, sterol regulatory element-binding protein 1c (SREBP-1c), and its role in the control of PEPCK-C gene transcription.
Chakravarty
Kaushik
K
Department of Cardiovascular Medicine, Discovery Biology, Pfizer La Jolla, San Diego, California 92121, USA. kaushik.chakravarty@pfizer.com
Hanson
Richard W
RW
D000818:Animals; D050260:Carbohydrate Metabolism; D006801:Humans; D007328:Insulin / Q000502:physiology*; D019764:Phosphoenolpyruvate Carboxykinase (ATP) / Q000378:metabolism*; D051780:Sterol Regulatory Element Binding Protein 1 / Q000502:physiology*; D014157:Transcription Factors; D014158:Transcription, Genetic
D007328:Insulin; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D019764:Phosphoenolpyruvate Carboxykinase (ATP)