Predicting the drug concentration in starch acetate matrix tablets from ATR-FTIR spectra using multi-way methods.
The amounts of drug and excipient were predicted from ATR-FTIR spectra using two multi-way modelling techniques, parallel factor analysis (PARAFAC) and multi-linear partial least squares (N-PLS). Data matrices consisted of dissolved and undissolved parallel samples having different drug content and spectra, which were collected at axially cut surface of the flat-faced matrix tablets. Spectra were recorded comprehensively at different points on the axially cut surface of the tablet. The sample drug concentrations varied between 2 and 16% v/v. The multi-way methods together with ATR-FTIR spectra seemed to represent an applicable method for the determination of drug and excipient distribution in a tablet during the release process. The N-PLS calibration method was more robust for accurate quantification of the amount of components in the sample whereas the PARAFAC model provided approximate relative amounts of components.
Matero
Sanni
S
Department of Pharmaceutical Chemistry, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland. sanni.matero@uku.fi
Pajander
Jari
J
Soikkeli
Anne-Marie
AM
Reinikainen
Satu-Pia
SP
Lahtela-Kakkonen
Maija
M
Korhonen
Ossi
O
Ketolainen
Jarkko
J
Poso
Antti
A
D002626:Chemistry, Pharmaceutical / Q000379:methods; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry; D011237:Predictive Value of Tests; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013213:Starch / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D013607:Tablets
D004364:Pharmaceutical Preparations; D013607:Tablets; D013213:Starch; C050766:starch acetate