title: Synthesis of 3-substituted 2-fluoro- and 2,2-difluoroaziridines.
abstract: A new route for the synthesis of stable 3-alkyl- and 3-aryl-2(,2)-(di)fluoroaziridines was developed by hydride reduction of novel alpha-bromo- and alpha-chloro-alpha(,alpha)-(di)fluoroketimines and subsequent ring closure of beta-fluorinated beta-chloro- and beta-bromoamines. This is the first report on the synthesis of 2,2-difluoroaziridines sensu stricto.
authors.affiliation: Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
authors.forename: Eva
authors.initials: E
authors.lastname: Van Hende
authors.forename: Guido
authors.initials: G
authors.lastname: Verniest
authors.forename: Riccardo
authors.initials: R
authors.lastname: Surmont
authors.forename: Norbert
authors.initials: N
authors.lastname: De Kimpe
mesh_terms: D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D005461:Fluorine / Q000737:chemistry*
chemical_list: D001388:Aziridines; D005461:Fluorine