title: Does vitamin E prevent gentamicin-induced ototoxicity?
abstract: A randomized double-blind study was performed to check the protective efficacy of vitamin E against aminoglycoside ototoxicity. 52 patients scheduled for gentamicin therapy because of acute pulmonary infections have been tested. Volunteers were randomly assigned to receive additionally either vitamin E or placebo. The daily dosage of gentamicin amounted to 240 mg and that of vitamin E to 2800 mg. The treatment lasted 7 days. Hearing function was assessed before the start of medication and at the follow-up visit 6 to 8 weeks afterwards. Elevation of auditory thresholds occurred in similar number of patients in the vitamin-E and placebo groups and no statistically significant differences were found between. Vitamin E has been not confirmed thus to possess any protective action against gentamicin-induced ototoxicity.
authors.affiliation: Centre of Audiology and Hearing Rehabilitation, Tbilisi, Georgia.
authors.forename: E
authors.initials: E
authors.lastname: Kharkheli
authors.forename: Z
authors.initials: Z
authors.lastname: Kevanishvili
authors.forename: T
authors.initials: T
authors.lastname: Maglakelidze
authors.forename: O
authors.initials: O
authors.lastname: Davitashvili
authors.forename: J
authors.initials: J
authors.lastname: Schacht
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D034381:Hearing Loss / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D018410:Pneumonia, Bacterial / Q000188:drug therapy; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010919:Placebos; D014810:Vitamin E