[Apolipoprotein E polymorphism in first-degree relatives of patients with familial or sporadic Alzheimer's disease].
BACKGROUND
Apolipoprotein E (apo E) has been recognized as a risk factor for Alzheimer disease (AD).


OBJECTIVE
To analyze apo E polymorphism in first-degree relatives of patients with familial or sporadic late-onset AD comparing with families without AD.


METHODS
Forty patients with familial or sporadic late-onset of AD, being both groups classified as probable, according of NINCS-ADRDAs criteria.


RESULTS
Allele epsilon3 was the most frequent in all of these groups. Higher frequency of epsilon4 when comparing the relatives of the probands with the relatives of the control group (p<0,0001) was observed. Allele epsilon2 showed significant difference only between relatives of familial AD and relatives of control group (p=0,026).


CONCLUSIONS
Apo E polymorphism has not differentiated familial from sporadic AD. The study of families allows to amplify the alelles epsilon2 and epsilon4 representative, revealing, their value as protecting factor and of risk for AD, respectively.
Cação
João de Castilho
Jde C
Departamento de Medicina I, Faculdade de Medicina de São José do Rio Preto SP, Brazil. jccacao@terra.com.br
Souza
Dorotéia Rossi Silva
DR
Tognola
Waldir Antonio
WA
Godoy
Maria Regina Pereira de
MR
Pinhel
Marcela Augusta de Souza
MA
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005190:Family; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044465:White People
D001057:Apolipoproteins E