A complex solution to a sexual dilemma.
The C. elegans male sex-determining protein, FEM-1, has been identified as a substrate recognition subunit of a Cullin-2 ubiquitin ligase complex. This complex controls the level of TRA-1A, a Ci/Gli homolog and master regulator of sex determination, by ubiquitin-mediated proteolysis.
Kuwabara
Patricia E
PE
Department of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom. p.kuwabara@bristol.ac.uk
D000818:Animals; D017173:Caenorhabditis elegans / Q000254:growth & development* / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D012734:Disorders of Sex Development; D019849:Sex Determination Processes
D029742:Caenorhabditis elegans Proteins