[Modern conception of protein kinase C role in the vascular smooth muscles tone regulation].
Protein kinase C is an important regulatory enzyme that plays significant role in the vascular tone regulation. Protein kinase C is involved in the vascular smooth muscle cells (SMC) contractility at physiological conditions and its hyperreactivity at different types of pathology. Myogenic and endothelium-dependent pathways of protein kinase C-mediated vascular tone regulation include a variety of cellular mechanisms. The most important protein kinase C-mediated mechanisms in SMC are the increase of myophilament Ca2+-sensitivity; regulation of plasmolema ion permeability, and proliferative changes in SMC. Protein kinase C-related mechanisms in vascular endotheliocytes include regulation of formation and transduction of humoral and electrical signals to SMC that play an important role in the pathological vasospasm development.
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D000818:Animals; D006801:Humans; D009129:Muscle Tonus / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000201:enzymology* / Q000502:physiology; D011493:Protein Kinase C / Q000378:metabolism*; D014661:Vasoconstriction / Q000502:physiology*
D011493:Protein Kinase C