title: The clinical application of metabolic therapy for cardiovascular disease.
abstract: Metabolic therapy involves the administration of a substance normally found in the body to enhance a metabolic reaction within the cell. This may be achieved in two ways. Firstly, for some systems a substance can be given to achieve greater than normal levels in the body so as to drive an enzymic reaction in a preferred direction. Secondly, metabolic therapy may be used to correct an absolute or relative deficiency of a cellular component. Thus, metabolic therapy differs greatly from most standard cardiovascular pharmacologic therapies such as the use of ACE Inhibitors, beta-blockers, statins and calcium channel antagonists that are given to block rather than enhance cellular processes.
authors.affiliation: Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital and Baker Heart Research Institute, Victoria, Australia.
authors.forename: Anthony
authors.initials: A
authors.lastname: Hadj
authors.forename: Salvatore
authors.initials: S
authors.lastname: Pepe
authors.forename: Franklin
authors.initials: F
authors.lastname: Rosenfeldt
mesh_terms: D000222:Adaptation, Physiological; D002318:Cardiovascular Diseases / Q000628:therapy*; D003067:Coenzymes; D015444:Exercise; D005947:Glucose; D006333:Heart Failure; D006801:Humans; D006973:Hypertension; D007328:Insulin; D019122:Meditation; D009963:Orotic Acid / Q000031:analogs & derivatives; D026741:Physical Therapy Modalities; D011188:Potassium; D008063:Thioctic Acid; D014451:Ubiquinone / Q000031:analogs & derivatives
chemical_list: D003067:Coenzymes; D007328:Insulin; D014451:Ubiquinone; D009963:Orotic Acid; D008063:Thioctic Acid; C024989:coenzyme Q10; C104468:magnesium orotate; D005947:Glucose; D011188:Potassium