title: Origin of ganglioside complex antibodies in Guillain-Barré syndrome.
abstract: The origin of antibodies to ganglioside complexes, as new immunotargets for Guillain-Barré syndrome (GBS), is unknown. This was investigated in 21 GBS patients from which Campylobacter jejuni was isolated. Two of these patients had serum IgG to the GM1/GD1a complex and two other patients had IgG to the GQ1b/GD1a complex. These pairs of patients were clinically distinct. These antibodies all cross-reacted to lipo-oligosaccharides (LOS) from the autologous C. jejuni strain. Previous mass spectrometry studies on these LOS showed the presence of oligosaccharides with a similar structure, further supporting the hypothesis that in these patients LOS induced the ganglioside complex antibodies.
authors.affiliation: Department of Neurology, Erasmus MC, 's-Gravendijkwal 230, Rotterdam, The Netherlands. m.kuijf@erasmusmc.nl <m.kuijf@erasmusmc.nl>
authors.forename: Mark L
authors.initials: ML
authors.lastname: Kuijf
authors.forename: Peggy C R
authors.initials: PC
authors.lastname: Godschalk
authors.forename: Michel
authors.initials: M
authors.lastname: Gilbert
authors.forename: Hubert P
authors.initials: HP
authors.lastname: Endtz
authors.forename: Anne P
authors.initials: AP
authors.lastname: Tio-Gillen
authors.forename: C Wim
authors.initials: CW
authors.lastname: Ang
authors.forename: Pieter A
authors.initials: PA
authors.lastname: van Doorn
authors.forename: Bart C
authors.initials: BC
authors.lastname: Jacobs
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D016123:Campylobacter jejuni / Q000276:immunology* / Q000378:metabolism; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000906:Antibodies; D005732:Gangliosides