title: Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers.
abstract: Autologous Preparation Rich in Growth Factors (PRGF), a small volume of plasma enriched in platelets, is a novel therapeutic strategy for the acceleration of the wound healing of a wide range of tissues because of the continuous release of multiple growth factors, including PDGF-AB, TGF-beta1, IGF-I, HGF, VEGF-A, and EGF. In this article, we have characterized the PRGF preparation and designed a randomized open-label controlled pilot trial to evaluate the effectiveness of PRGF in the treatment of chronic cutaneous ulcers. Results showed that at 8 weeks, the mean percentage of surface healed in the PRGF group was 72.94% +/- 22.25% whereas it was 21.48% +/- 33.56% in the control group (p < 0.05). These results, with the limitations of a pilot study, suggest that topical application of PRGF is more effective than standard therapy in helping a chronic ulcer to heal.
authors.affiliation: Biotechnology Institute, Vitoria, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Anitua
authors.forename: José J
authors.initials: JJ
authors.lastname: Aguirre
authors.forename: Jaime
authors.initials: J
authors.lastname: Algorta
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ayerdi
authors.forename: Ana I
authors.initials: AI
authors.lastname: Cabezas
authors.forename: Gorka
authors.initials: G
authors.lastname: Orive
authors.forename: Isabel
authors.initials: I
authors.lastname: Andia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001804:Blood Transfusion, Autologous; D002908:Chronic Disease; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D017713:Platelet Transfusion; D012883:Skin Ulcer / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins