title: A comparison of ionic liquids to molecular organic solvents as additives for chiral separations in micellar electrokinetic chromatography.
abstract: In this study, we report the effects of adding ionic liquids (ILs), as compared to adding conventional molecular organic solvents (MOSs), to aqueous buffer solutions containing molecular micelles in the separation of chiral analyte mixtures in micellar EKC (MEKC). The molecular micelle used in this study was polysodium oleyl-L-leucylvalinate (poly-L-SOLV). The ILs were 1-alkyl-3-methylimidazolium tetrafluoroborate, where the alkyl group was ethyl, butyl, hexyl, or octyl. These ILs were chosen due to their hydrophobicity, good solvating, and electrolyte properties. Thus, it was expected that these ILs would have favorable interactions with chiral analytes and not adversely affect the background current. Common CE buffers, mixed with a molecular micelle, and an IL or a MOS, were used for these chiral separations. The buffers containing an IL in the concentration range of 0.02-0.1 v/v were found to support a reasonable current when an electric field strength of 500 V/cm was applied across the capillary. However, a current break down was observed for the buffers containing more than 60% v/v MOS on application of the above-mentioned electric field. The chiral resolution and selectivity of the analytes were dependent on the concentration and type of IL or MOS used.
authors.affiliation: Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana, USA.
authors.forename: Simon M
authors.initials: SM
authors.lastname: Mwongela
authors.forename: Noreen
authors.initials: N
authors.lastname: Siminialayi
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Fletcher
authors.forename: Isiah M
authors.initials: IM
authors.lastname: Warner
mesh_terms: D000097:Acetonitriles; D001573:Benzoin / Q000031:analogs & derivatives; D001881:Borates; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods; D004563:Electrochemistry / Q000379:methods; D007093:Imidazoles; D052578:Ionic Liquids; D000432:Methanol; D009281:Naphthalenes; D010755:Organophosphates; D011433:Propranolol; D012997:Solvents; D013237:Stereoisomerism
chemical_list: C419324:1-butyl-3-methylimidazolium tetrafluoroborate; C499119:1-ethyl-3-methylimidazolium tetrafluoroborate; D000097:Acetonitriles; D001881:Borates; D007093:Imidazoles; D052578:Ionic Liquids; D009281:Naphthalenes; D010755:Organophosphates; D012997:Solvents; C107195:1,1'-binaphthyl-2,2'-diyl hydrogen phosphate; D011433:Propranolol; D001573:Benzoin; D000432:Methanol; C032159:acetonitrile