title: The efficacy of an acrylic intraocular lens surface modified with polyethylene glycol in posterior capsular opacification.
abstract: To investigate if the surface modification of intraocular lens (IOL) is efficient in the prevention of posterior capsular opacification (PCO), the acrylic surface of intraocular lens (Acrysof) was polymerized with polyethylene glycol (PEG-IOL). The human lens epithelial cells (1 x 10(4) cells/mL) were inoculated on PEG grafted or unmodified acrylic lenses for the control. The adherent cells on each IOL surface were trypsinized and counted. The every PEG-IOL was implanted in 20 New Zealand rabbits after removal of crystalline lens. The formations of PCO were checked serially through retroilluminated digital photography, and the severity scores were calculated using POCOman. The cell adherence patterns on each IOL were examined by scanning electron microscopy. As a result, the mean number of adherent cells of PEG-IOL (3.2+/-1.1 x 10(3)) tended to be smaller than that of the acrylic controls (3.6+/-1.9 x 10(3)) without a statistical significance (p=0.73). However, the mean severity of PCO formation in PEG-IOL was significantly lower than that in the control during the third to sixth weeks after surgery. Scanning electron microscopy revealed that the more patch-like cells were found firmly attached to the IOL surface in control than in the PEG-IOL. Conclusively, PEG polymerization to the acrylic IOL would possibly lessen the formation of PCO after cataract removal.
authors.affiliation: Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
authors.forename: Hyeon Il
authors.initials: HI
authors.lastname: Lee
authors.forename: Mee Kum
authors.initials: MK
authors.lastname: Kim
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Ko
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Lee
authors.forename: Won Ryang
authors.initials: WR
authors.lastname: Wee
authors.forename: Jin Hak
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D001672:Biocompatible Materials; D002386:Cataract / Q000378:metabolism / Q000628:therapy*; D002448:Cell Adhesion; D006801:Humans; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007908:Lens, Crystalline / Q000166:cytology / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000378:metabolism; D013997:Time Factors
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D011092:Polyethylene Glycols