Transcriptional control of the Pgc-1alpha gene in skeletal muscle in vivo.
Endurance exercise promotes mitochondrial biogenesis in skeletal muscle possibly by inducing peroxisome proliferator-activated receptor gamma coactivator 1alpha gene transcription through activation of the p38 mitogen-activated protein kinase pathway. A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1alpha gene in skeletal muscle in vivo.
Yan
Zhen
Z
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA. zhen.yan@duke.edu
Li
Ping
P
Akimoto
Takayuki
T
D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics*; D051379:Mice; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D047493:PPAR alpha / Q000235:genetics* / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic; D048051:p38 Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism
D024101:Mitochondrial Proteins; D047493:PPAR alpha; D014157:Transcription Factors; D048051:p38 Mitogen-Activated Protein Kinases