A new chromone, 11-hydroxy-sec-O-glucosylhamaudol from Ostericum koreanum.
From the ethyl acetate fraction of the roots of Ostericum koreanum, a new chromone, 11-hydroxy-sec-O-glucosylhamaudol (1) along with the known compounds: four chromones, three coumarins, six phenolic compounds, and three quinic acids were isolated. These compounds were assessed for antioxidant activities in the DPPH radical and superoxide anion radical scavenging assay systems. Among isolates, 4-(2-hydroxy-vinyl)-benzene-1,2-diol (12) showed the most potent DPPH radical scavenging activity (IC(50)=4.80+/-0.62 mug/ml) and superoxide anion radical scavenging activity (IC(50)=11.05+/-0.83 microg/ml) in the xanthine/xanthine oxidase system. The antioxidant activities of 12 were comparable to those of quercetin and luteolin.
Park
Yeo Jin
YJ
Bioanalysis and Biotransformation Research Center, Division of Life Sciences, Korea Institute of Science & Technology, Seoul, Korea.
Kim
Hyoung Ja
HJ
Lee
Sook Ja
SJ
Choi
Ho-Young
HY
Jin
Changbae
C
Lee
Yong Sup
YS
D019661:Apiaceae / Q000737:chemistry*; D002867:Chromones / Q000737:chemistry* / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D013481:Superoxides / Q000737:chemistry; D014969:Xanthine Oxidase / Q000737:chemistry
C522657:11-hydroxy-sec-O-glucosylhamaudol; D002867:Chromones; D004365:Drugs, Chinese Herbal; D013481:Superoxides; C001324:hamaudol; D014969:Xanthine Oxidase