title: First round of a focused library of cholera toxin inhibitors.
abstract: C-Galactosides have been used as scaffolds to design a library of non-hydrolysable inhibitors of cholera toxin (CT). Test elements from the library were synthesized and found to inhibit CT binding to an asialofetuin-coated SPR chip with micromolar affinity. Preliminary results are reported.
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Universita degli Studi di Milano, Via Venezian 21, I-20133 Milano, Italy.
authors.forename: Crtomir
authors.initials: C
authors.lastname: Podlipnik
authors.forename: Ingrid
authors.initials: I
authors.lastname: Velter
authors.forename: Barbara
authors.initials: B
authors.lastname: La Ferla
authors.forename: Gilles
authors.initials: G
authors.lastname: Marcou
authors.forename: Laura
authors.initials: L
authors.lastname: Belvisi
authors.forename: Francesco
authors.initials: F
authors.lastname: Nicotra
authors.forename: Anna
authors.initials: A
authors.lastname: Bernardi
mesh_terms: D000992:Antitoxins / Q000737:chemistry* / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002772:Cholera Toxin; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000992:Antitoxins; D006027:Glycosides; D009844:Oligosaccharides; D002772:Cholera Toxin