title: Characteristic changes in platelet-large cell ratio, lactate dehydrogenase and C-reactive protein in thrombocytosis-related diseases.
abstract: We examined the clinical usefulness of 3 parameters of routine laboratory tests [platelet-large cell ratio (P-LCR), lactate dehydrogenase (LDH) and C-reactive protein (CRP)] in 84 patients with thrombocytosis-related diseases (reactive thrombocytosis, chronic myeloid leukemia, essential thrombocythemia and polycythemia vera). These thrombocytosis-related diseases were characterized using the 3 parameters P-LCR, LDH and CRP as follows: high P-LCR and high LDH in chronic myeloid leukemia; high CRP in reactive thrombocytosis; slightly high P-LCR and high LDH in essential thrombocythemia and polycythemia vera. For essential thrombocythemia and polycythemia vera, levels of P-LCR and CRP were nearly identical, but the LDH level in essential thrombocythemia was significantly higher than in polycythemia vera. These characteristics of P-LCR, LDH and CRP may be useful for simple and very rough differentiation of the thrombocytosis-related disease mentioned above.
authors.affiliation: Central Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka, Japan. kabutomori@hp-lab.med.osaka-u.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Kabutomori
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kanakura
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Iwatani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001792:Blood Platelets / Q000648:ultrastructure*; D002097:C-Reactive Protein / Q000032:analysis*; D048429:Cell Size; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011087:Polycythemia Vera / Q000097:blood*; D013920:Thrombocythemia, Essential / Q000097:blood*; D013922:Thrombocytosis / Q000097:blood* / Q000209:etiology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase