Enhancing effects of new biological response modifier beta-1,3 glucan sulfate PS3 on immune reactions.
Glucans have a long history as non-specific biological modulators; however, but the search for optimal chemical configuration is still on. The objective of this study was to evaluate intraperitoneal application of PS3, a sulfated derivative of a (1-->3)-beta-D-glucan isolated from sporophytes of Laminaria digitata. PS3 showed significant stimulation of phagocytic activity as well as potentiation of synthesis and release of IL-2 by splenocytes. In addition, PS3 increased NK cell-mediated killing of tumor cells both in vitro and in vivo. When combined, our observations suggest that PS3 is similarly effective as native non-sulfated (1-->3)-beta-D-glucan and is generally more active than lentinan.
Vetvicka
Vaclav
V
University of Louisville, Department of Pathology, Louisville, KY 40202, USA. vaclav.vetvicka@louisville.edu
Vetvickova
Jana
J
Frank
Jamois
J
Yvin
Jean-Claude
JC
D000818:Animals; D045744:Cell Line, Tumor; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D005936:Glucans / Q000494:pharmacology*; D007155:Immunologic Factors / Q000494:pharmacology*; D007376:Interleukin-2 / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007795:Laminaria / Q000737:chemistry*; D007912:Lentinan / Q000494:pharmacology; D051379:Mice; D008863:Microspheres; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D009368:Neoplasm Transplantation; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D005936:Glucans; D007155:Immunologic Factors; D007376:Interleukin-2; C532541:PS3 glucan; D007912:Lentinan