title: Management of diabetic ketoacidosis in PICU.
abstract: OBJECTIVE
  This study was undertaken to analyze the outcome of children with DKA treated with a modified protocol at a tertiary level teaching hospital PICU in Pune, Maharashatra.
  
  
  METHODS
  We retrospectively analyzed case records of 12 patients (8 males and 4 females) with DKA (11 new and 1 readmission) admitted in our PICU from January 2005 to June 2006. Patients were managed according to a modified protocol (that is with less intensive biochemical monitoring when compared with standard book protocols). Laboratory parameters measured were blood glucose, urinary ketones, electrolytes, urea creatinine, arterial blood gas (ABG) and infectious screen. Treatment included fluid therapy and insulin infusion- 0.1 u/Kg short acting intravenously followed by 0.1 u/Kg/hr. No bicarbonate was administered as a bolus.
  
  
  RESULTS
  Total fluid deficit was corrected slowly over a period of 36 hr. The median time to normalize ABG was 19 hr (5.3-39) while the median time for the urinary ketones to disappear was 1day (1-3). The child to nurse ratio was 1:2, there were 2 pediatric residents in house all 24 hr with an intensivist and pediatric endocrinologist on call.
  
  
  CONCLUSIONS
  We have shown that when DKA is managed in a PICU setting using modified protocol, the outcome is good and complications such as brain edema can be prevented.
authors.affiliation: Bharati Vidyapeeth Deemed University Medical College, Dhankawadi, Pune, India.
authors.forename: R R
authors.initials: RR
authors.lastname: Jahagirdar
authors.forename: V V
authors.initials: VV
authors.lastname: Khadilkar
authors.forename: A V
authors.initials: AV
authors.lastname: Khadilkar
authors.forename: S K
authors.initials: SK
authors.lastname: Lalwani
mesh_terms: D017677:Age Distribution; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016883:Diabetic Ketoacidosis / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007328:Insulin / Q000008:administration & dosage; D015278:Intensive Care Units, Pediatric; D008297:Male; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D007328:Insulin