title: [Human metapneumovirus as a common cause of respiratory tract disease].
abstract: Human metapneumovirus (HMPV), the newly identified paramyxovirus, causes respiratory infections in children, immunosuppressed patients, and the elderly in different countries of the world. The epidemiology and clinical manifestations of HMPV infection are similar to those in human respiratory syncytial virus infection. The diagnosis of HMPV infection is based on the polymerase chain reaction detection of viral RNA or the recording of rising serum antibody titers. There are at least two genotypes and several subtypes of HMPV in the human population. The use of cell cultures and laboratory animals have provided new evidence for the pathogenesis of HMPV infection, the specific features of antiviral immunity and enabled recombinant HMPV vaccine candidates to be designed.
authors.forename: L A
authors.initials: LA
authors.lastname: Mazhul'
authors.forename: O
authors.initials: O
authors.lastname: Schildgen
authors.forename: E I
authors.initials: EI
authors.lastname: Isaeva
authors.forename: S O
authors.initials: SO
authors.lastname: Viazov
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D014644:Genetic Variation; D016679:Genome, Viral; D014943:Global Health; D006801:Humans; D029121:Metapneumovirus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D018184:Paramyxoviridae Infections / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D012141:Respiratory Tract Infections / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D013045:Species Specificity; D014614:Vaccines, Synthetic / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral; D014614:Vaccines, Synthetic; D014765:Viral Vaccines