Ultrastructural and immunohistochemical study of hepatic stellate cells over the course of infectious viral fibrosis and cirrhosis of the liver.
The dynamics of structural and functional changes in stellate cells in liver biopsy specimens (from lipid-containing to fibrogenous phenotype) was studied during the development of infectious viral fibrosis and cirrhosis of the liver using ultrastructural, immunohistochemical, and morphometric methods. The priority role of stellate cells in the synthesis of extracellular matrix components is emphasized. Resorption of perihepatocellular collagen fibrils is associated with parenchymatous liver cells.
Nepomnyashchikh
G I
GI
Department of Regional Pathology and Pathomorphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. gi_nepom@soramn.ru
Aidagulova
S V
SV
Nepomnyashchikh
D L
DL
Kapustina
V I
VI
Postnikova
O A
OA
D001706:Biopsy; D005355:Fibrosis / Q000378:metabolism / Q000473:pathology / Q000821:virology; D019698:Hepatitis C, Chronic / Q000473:pathology; D022781:Hepatocytes / Q000473:pathology / Q000648:ultrastructure / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008099:Liver / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism* / Q000601:surgery; D008103:Liver Cirrhosis / Q000378:metabolism / Q000473:pathology