title: Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study.
abstract: BACKGROUND
  3-year subcutaneous specific immunotherapy (SIT) in children with seasonal allergic rhinoconjunctivitis reduced the risk of developing asthma during treatment and 2 years after discontinuation of SIT (5-year follow-up) indicating long-term preventive effect of SIT.
  
  
  OBJECTIVE
  We evaluated the long-term clinical effect and the preventive effect of developing asthma 7-years after termination of SIT.
  
  
  METHODS
  One hundred and forty-seven subjects, aged 16-25 years with grass and/or birch pollen allergy was investigated 10 years after initiation of a 3-year course of SIT with standardized allergen extracts of grass and/or birch or no SIT respectively. Conjunctival provocations were performed outside the season and methacholine bronchial provocations were performed during the season and winter. Asthma was assessed by clinical evaluation.
  
  
  RESULTS
  The significant improvements in rhinoconjunctivitis and conjunctival sensitivity persisted at the 10-year follow-up. Significantly less actively treated subjects had developed asthma at 10-year follow-up as evaluated by clinical symptoms [odds ratio 2.5 (1.1-5.9)]. Patients who developed asthma among controls were 24/53 and in the SIT group 16/64. The longitudinal treatment effect when adjusted for bronchial hyper-responsiveness and asthma status at baseline including all observations at 3, 5 and 10 years follow-up (children with or without asthma at baseline, n = 189; 511 observations) was statistically significant (P = 0.0075). The odds ratio for no-asthma was 4.6 95% CI (1.5-13.7) in favor of SIT.
  
  
  CONCLUSIONS
  A 3-year course of SIT with standardized allergen extracts has shown long-term clinical effects and the potential of preventing development of asthma in children with allergic rhinoconjunctivitis up to 7 years after treatment.
  
  
  CONCLUSIONS
  Specific immunotherapy has long-term clinical effects and the potential of preventing development of asthma in children with allergic rhino conjunctivitis up to 7 years after treatment termination.
authors.affiliation: ALK-Abelló, Hørsholm, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Jacobsen
authors.forename: B
authors.initials: B
authors.lastname: Niggemann
authors.forename: S
authors.initials: S
authors.lastname: Dreborg
authors.forename: H A
authors.initials: HA
authors.lastname: Ferdousi
authors.forename: S
authors.initials: S
authors.lastname: Halken
authors.forename: A
authors.initials: A
authors.lastname: Høst
authors.forename: A
authors.initials: A
authors.lastname: Koivikko
authors.forename: L A
authors.initials: LA
authors.lastname: Norberg
authors.forename: E
authors.initials: E
authors.lastname: Valovirta
authors.forename: U
authors.initials: U
authors.lastname: Wahn
authors.forename: C
authors.initials: C
authors.lastname: Möller
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology / Q000627:therapeutic use*; D052179:Antigens, Plant; D001249:Asthma / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D029662:Betula / Q000276:immunology; D001985:Bronchial Provocation Tests / Q000379:methods; D003888:Desensitization, Immunologic / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D016017:Odds Ratio; D010147:Pain Measurement / Q000379:methods; D010940:Plant Proteins / Q000276:immunology / Q000627:therapeutic use; D006109:Poaceae / Q000276:immunology; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D012307:Risk Factors; D012882:Skin Tests / Q000379:methods; D013995:Time
chemical_list: D000485:Allergens; D052179:Antigens, Plant; C076049:Phl p V protein, Phleum pratense; D010940:Plant Proteins; C061312:Bet v 1 allergen, Betula