title: The role of apoptosis in autoantibody production.
abstract: Apoptosis is the physiologic process that guarantees the cellular exchange; after apoptosis the cellular remains are cleared by phagocytosis. In autoimmunity, some mechanisms in apoptosis fail and may result in disease. For instance, a failure in the Fas pathway during lymphoid ontogeny may allow the survival of autoimmune clones; equally the lack of clearance of apoptotic corps containing self-antigens may activate pre-existent auto-reactive clones and may result in autoantibody production. The role of apoptosis in autoimmunity is reviewed.
authors.forename: R
authors.initials: R
authors.lastname: Herrera-Esparza
authors.forename: D
authors.initials: D
authors.lastname: Herrera-van-Oostdam
authors.forename: E
authors.initials: E
authors.lastname: López-Robles
authors.forename: E
authors.initials: E
authors.lastname: Avalos-Díaz
mesh_terms: D017209:Apoptosis / Q000276:immunology*; D001323:Autoantibodies / Q000096:biosynthesis*; D006801:Humans
chemical_list: D001323:Autoantibodies