Paraoxonase and arylesterase activities in fibromyalgia.
We aimed to evaluate the association of serum paraoxonase and arylesterase activities and oxidative/antioxidative status in patients with fibromyalgia. Forty-two patients with fibromyalgia and 53 healthy controls were included in the study. Serum paraoxonase and arylesterase activities were measured spectrophotometrically. Oxidative and antioxidative status were evaluated by measuring serum lipid hydroperoxide (LOOH) levels, total antioxidant status (TAS) and free sulfhydryl groups (-SH = total thiol). Lipid parameters were determined by routine laboratory methods. Serum paraoxonase and arylesterase activities, and TAS were lower in patients with fibromyalgia than in controls (P < 0.001, for all), and the -SH level was also lower in the patient group (P = 0.03). LOOH levels were higher in the patient group than in controls (P = 0.01). Our results suggest that patients with fibromyalgia were exposed to oxidative stress, and paraoxonase and arylesterase activities were decreased in these patients. Patients with fibromyalgia might be prone to development of atherosclerosis with reduced paraoxonase and arylesterase activities.
Altindag
Ozlem
O
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Harran University, Sanliurfa, Turkey. ozaltindag@yahoo.com <ozaltindag@yahoo.com>
Gur
Ali
A
Calgan
Nazife
N
Soran
Neslihan
N
Celik
Hakim
H
Selek
Sahabettin
S
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000201:enzymology* / Q000503:physiopathology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D016877:Oxidants / Q000097:blood; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013438:Sulfhydryl Compounds / Q000097:blood
D000975:Antioxidants; D007527:Isoenzymes; D008054:Lipid Peroxides; D016877:Oxidants; D013438:Sulfhydryl Compounds; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase