Evidence of intragenic recombination in G1 rotavirus VP7 genes.
The G1 rotavirus is the most widespread genotype causing acute gastroenteritis in children. In an attempt to investigate the occurrence of intragenic recombination, 131 complete coding region sequences of VP7 genes of the G1 rotaviruses in GenBank were examined. Three hitherto-unreported intragenic recombinant rotaviruses were identified. It was noteworthy that two different types (interlineage and intersublineage) of intragenic recombination in rotaviruses were also found. This is the first report to demonstrate the existence of intragenic recombinations between interlineage and intersublineage in G1 rotaviruses.
Phan
Tung Gia
TG
Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033.
Okitsu
Shoko
S
Maneekarn
Niwat
N
Ushijima
Hiroshi
H
D000956:Antigens, Viral / Q000235:genetics*; D036022:Capsid Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D010802:Phylogeny; D011995:Recombination, Genetic; D012401:Rotavirus / Q000235:genetics*; D012400:Rotavirus Infections / Q000453:epidemiology / Q000235:genetics*
D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus