title: [Chemico-toxicological analysis of haloperidol in blood with high-performance liquid chromatography in combined poisoning].
abstract: Haloperidol is widely used in psychiatric practice both in monotherapy and in combination with neuroleptics, phenothiazine derivatives (chlorpromasin, levomepromasin) and antidepressants (amitriptilin, imipramin). We have developed techniques of haloperidol isolation from blood in combined poisonings with phenothiazine derivatives (chlorpromazine, levomepromasine) and antidepressants (amitriptilin, imipramin), their identification and quantitation with high-performance liquid chromatography. The highest output of the substances studied was achieved in alkaline hydrolysis. The techniques are expressive, sensitive and well reproducible. This makes them convenient for practice of forensic-chemical and chemico-toxicological laboratories.
authors.forename: A B
authors.initials: AB
authors.lastname: Skorniakova
authors.forename: D S
authors.initials: DS
authors.lastname: Lazarian
authors.forename: M G
authors.initials: MG
authors.lastname: Tsybulina
mesh_terms: D014150:Antipsychotic Agents / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D053593:Forensic Toxicology / Q000379:methods*; D006220:Haloperidol / Q000097:blood*; D006801:Humans; D011041:Poisoning / Q000097:blood* / Q000209:etiology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D006220:Haloperidol