Indium(III) trifluoromethanesulfonate as an efficient catalyst for the deprotection of acetals and ketals.
Acetals and ketals are readily deprotected under neutral conditions in the presence of acetone and catalytic amounts of indium(III) trifluoromethanesulfonate (<0.8 mol %) at room temperature or mild microwave heating conditions to give the corresponding aldehydes and ketones in good to excellent yields.
Gregg
Brian T
BT
Department of Medicinal Chemistry, AMRI, Albany, NY 12203, USA. brian.gregg@amriglobal.com
Golden
Kathryn C
KC
Quinn
John F
JF
D000080:Acetals / Q000737:chemistry*; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000080:Acetals; C522942:Indium(III) trifluoromethanesulfonate; D009942:Organometallic Compounds