title: The intracellular region of Notch ligands: does the tail make the difference?
abstract: The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals.
authors.affiliation: International Centre for Genetic Engineering and Biotechnology, Protein Structure and Bioinformatics Group, AREA Science Park, Padriciano 99, I-34012 Trieste, Italy. pintar@icgeb.org
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pintar
authors.forename: Alfredo
authors.initials: A
authors.lastname: De Biasio
authors.forename: Matija
authors.initials: M
authors.lastname: Popovic
authors.forename: Neli
authors.initials: N
authors.lastname: Ivanova
authors.forename: Sándor
authors.initials: S
authors.lastname: Pongor