title: International Cartilage Repair Society (ICRS) and Oswestry macroscopic cartilage evaluation scores validated for use in Autologous Chondrocyte Implantation (ACI) and microfracture.
abstract: OBJECTIVE
  For young patients with cartilage defects, the emergence of clinically applicable cell therapy for biological joint reconstruction is an appealing prospect. Acceptation of this method as a means of standard care requires proof of being reproducible, having long-lasting mechanical integrity, and having a good clinical outcome. This study evaluates the reliability of the International Cartilage Repair Society (ICRS) score and the Oswestry Arthroscopy Score (OAS) in the assessment of regenerative cartilage repair.
  
  
  METHODS
  A total of 101 macroscopic images of cartilage repair were made during arthroscopy 12 months post-treatment of either Autologous Chondrocyte Implantation (ACI) or microfracture. These images were examined by seven independent observers with differing levels of experience. The ICRS and OAS scores were randomly presented twice at a 4-week interval. All observers stated their predicted outcome according to actual treatment and defect size.
  
  
  RESULTS
  ICRS and OAS scores showed both good inter- and intra observer reliability (0.62 and 0.56 for ICRS; 0.73 and 0.65 for OAS, respectively). Internal consistency (Cronbach's alpha) was satisfactory for research purposes (0.79 and 0.74, respectively). Correlation (equivalence concordance) between both scoring systems was excellent (r=0.94). All observers were inconsistent in predicting actual treatment. Test-re test reliability of estimated defect size and its correlation to true defect size were poor. These results were also applicable to the sub-analyses of the experience of the observer and the quality of imaging.
  
  
  CONCLUSIONS
  The ICRS and OAS are reliable and relevant scores that are now both validated for macroscopic evaluation of cartilage repair as a research tool.
authors.affiliation: Department of Orthopaedics, University Medical Center Utrecht, The Netherlands.
authors.forename: M P J
authors.initials: MP
authors.lastname: van den Borne
authors.forename: N J H
authors.initials: NJ
authors.lastname: Raijmakers
authors.forename: J
authors.initials: J
authors.lastname: Vanlauwe
authors.forename: J
authors.initials: J
authors.lastname: Victor
authors.forename: S N
authors.initials: SN
authors.lastname: de Jong
authors.forename: J
authors.initials: J
authors.lastname: Bellemans
authors.forename: D B F
authors.initials: DB
authors.lastname: Saris
mesh_terms: D054544:Arthroplasty, Subchondral; D001182:Arthroscopy; D002358:Cartilage, Articular / Q000601:surgery*; D019902:Chondrocytes / Q000637:transplantation*; D006801:Humans; D010027:Osteotomy; D011446:Prospective Studies; D011897:Random Allocation; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014743:Videotape Recording