title: The -463G/A polymorphism in myeloperoxidase gene and cervical cancer.
abstract: BACKGROUND
  Cervical cancer is the leading cause of cancer-related death in women in developing countries. The -463 type G polymorphism of the MPO gene has been correlated with higher MPO expression and increased risk of various types of cancers. Our study was performed in order to evaluate the association between the -463G polymorphism and the prevalence of cervical cancer.
  
  
  METHODS
  In our prospective study, 149 patients with cervical cancer and 126 patients without any malignancies were enrolled.
  
  
  RESULTS
  No significant difference was found between genotype distributions in the cervical cancer patients and the control group. There was also no significant association of the genotype distributions with clinical prognostic factors. However, significantly lower A allele frequency of the -463 polymorphism of the MPO gene was found in our study group in comparison with that of the average Caucasian population.
  
  
  CONCLUSIONS
  The -463 polymorphism of the MPO gene was not associated with susceptibility to cervical cancer.
authors.affiliation: Department of Gynaecology and Obstetrics, Charité, Campus Virchow-Klinikum, Medical University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. alexander.mustea@charite.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Mustea
authors.forename: Georg
authors.initials: G
authors.lastname: Heinze
authors.forename: Jalid
authors.initials: J
authors.lastname: Sehouli
authors.forename: Dominique
authors.initials: D
authors.lastname: Koensgen
authors.forename: Andrea
authors.initials: A
authors.lastname: Wolf
authors.forename: Lilian
authors.initials: L
authors.lastname: Gutu
authors.forename: Dumitru
authors.initials: D
authors.lastname: Sofroni
authors.forename: Cristina
authors.initials: C
authors.lastname: Pirvulescu
authors.forename: Elena Ioana
authors.initials: EI
authors.lastname: Braicu
authors.forename: Eva
authors.initials: E
authors.lastname: Schuster
authors.forename: Robert
authors.initials: R
authors.lastname: Zeillinger
authors.forename: Dan
authors.initials: D
authors.lastname: Tong
mesh_terms: D005260:Female; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D015995:Prevalence; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics*
chemical_list: D009195:Peroxidase