Prognosis value of atrial natriuretic peptide and brain natriuretic peptide for heart failure in patients undergoing allogeneic bone marrow transplantation.
It is essential to evaluate the organ function of the recipient before bone marrow transplantation (BMT). This study investigated the usefulness of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels as indicators of cardiac function. Seventy-five consecutive patients undergoing allogeneic BMT were enrolled. All of them had an ejection fraction of 55% or more on echocardiography. Six of the 75 patients died of heart failure after transplantation and these 6 patients were compared with the other 69 patients to assess the prognostic value of the two natriuretic peptides. Both peptides remained normal from before conditioning until recovery from leukopenia in all 69 surviving patients. Among the 6 patients who died of heart failure, however, BNP was increased in all 6 patients and ANP was increased in five of them at an average of 43.6 +/- 16.7 days before the onset of heart failure. Monitoring of these peptides may not only be useful for assessment of cardiac function but also for predicting the occurrence of heart failure.
Takatsuka
Hiroyuki
H
Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Japan.
Nakajima
Toshiyuki
T
Nomura
Kaori
K
Okikawa
Yoshiko
Y
Wakae
Takeshi
T
Toda
Akinari
A
Itoi
Hisayuki
H
Okada
Masaya
M
Misawa
Mahito
M
Hara
Hiroshi
H
Ogawa
Hiroyasu
H
D000293:Adolescent; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D016026:Bone Marrow Transplantation / Q000401:mortality*; D016022:Case-Control Studies; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000628:therapy; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D015996:Survival Rate; D014184:Transplantation, Homologous
D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor