Relationship between interleukin-8 and the oxidant-antioxidant system in end-stage renal failure patients.
OBJECTIVE
We aimed to evaluate the relationship between interleukin-8 and the oxidant-antioxidant system in end-stage renal failure patients with and without diabetes mellitus undergoing regular hemodialysis treatment.


METHODS
Plasma levels of malondialdehyde and whole blood reduced glutathione were measured as markers of the oxidant and antioxidant systems, respectively. Plasma interleukin-8 levels were measured by enzyme-linked immunosorbent assay.


RESULTS
When compared with controls, plasma interleukin-8 levels were elevated in both diabetic and nondiabetic end-stage renal disease patients. Plasma malondialdehyde levels were statistically significantly higher in end-stage renal disease patients with and without diabetes mellitus than they were in controls; however, reduced glutathione levels were statistically significantly lower in diabetic and nondiabetic end-stage renal disease patients than they were controls.


CONCLUSIONS
In end-stage renal disease patients with and without diabetes mellitus, elevated interleukin- 8 levels and decreased reduced glutathione levels may be attributed to increased oxidative stress due to inflammation. In other words, increased reactive oxygen species may induce interleukin-8 production and result in diminished reduced glutathione levels. Our data suggest a relationship between interleukin- 8 and the oxidant-antioxidant system in end-stage renal failure patients.
Aydin
Makbule
M
Department of Neuroscience, Istanbul University, Institute for Experimental Medicine, Istanbul, Turkey. aydinm@istanbul.edu.tr
Ozkok
Elif
E
Ozturk
Oguz
O
Agachan
Bedia
B
Yilmaz
Hulya
H
Yaylim
Ilhan
I
Kebabcioglu
Seher
S
Ispir
Turgay
T
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism*
D000975:Antioxidants; D016209:Interleukin-8; D016877:Oxidants; D008315:Malondialdehyde; D005978:Glutathione