title: Transplant glomerulopathy: subclinical incidence and association with alloantibody.
abstract: Transplant glomerulopathy (TG) usually has been described as part of a constellation of late chronic histologic abnormalities associated with proteinuria and declining function. The current study used both protocol and clinically-indicated biopsies to investigate clinical and subclinical TG, their prognosis and possible association with alloantibody. We retrospectively studied 582 renal transplants with a negative pre-transplant T-cell complement dependent cytotoxicity crossmatch. TG was diagnosed in 55 patients, 27 (49%) based on protocol biopsy in well-functioning grafts. The cumulative incidence of TG increased over time to 20% at 5 years. The prognosis of subclinical TG was equally as poor as TG diagnosed with graft dysfunction, with progressive worsening of histopathologic changes and function. Although TG was associated with both acute and chronic histologic abnormalities, 14.5% of TG biopsies showed no interstitial fibrosis or tubular atrophy, while 58% (7/12) of biopsies with severe TG showed only minimal abnormalities. TG was associated with acute rejection, pretransplant hepatitis C antibody positivity and anti-HLA antibodies (especially anti-Class II), with the risk increasing if the antibodies were donor specific. We suggest that subclinical TG is an under-recognized cause of antibody-mediated, chronic renal allograft injury which may be mechanistically distinct from other causes of nephropathy.
authors.affiliation: Department of Internal Medicine, Division of Nephrology and Hypertension and Transplant Center, Mayo Clinic and Foundation, Rochester, MN, USA. gloor.james@mayo.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Gloor
authors.forename: S
authors.initials: S
authors.lastname: Sethi
authors.forename: M D
authors.initials: MD
authors.lastname: Stegall
authors.forename: W D
authors.initials: WD
authors.lastname: Park
authors.forename: S B
authors.initials: SB
authors.lastname: Moore
authors.forename: S
authors.initials: S
authors.lastname: DeGoey
authors.forename: M D
authors.initials: MD
authors.lastname: Griffin
authors.forename: T S
authors.initials: TS
authors.lastname: Larson
authors.forename: F G
authors.initials: FG
authors.lastname: Cosio
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D001706:Biopsy; D018450:Disease Progression; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D015433:Glomerulonephritis, Membranous / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D006084:Graft Rejection / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000648:ultrastructure; D016030:Kidney Transplantation / Q000276:immunology*; D008854:Microscopy, Electron; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D014184:Transplantation, Homologous
chemical_list: D001323:Autoantibodies; D006680:HLA Antigens