title: Discontinuation of living donor liver transplantation for PSC due to histological abnormalities in intraoperative donor liver biopsy.
abstract: Liver transplantation is the only curative treatment known to date for end-stage liver disease occurring as a result of primary sclerosing cholangitis (PSC). Here, we report a case in which living donor liver transplantation (LDLT) for PSC was cancelled because of histological abnormalities in intraoperative biopsy of the donor liver. The donor was the mother of the recipient, and her preoperative evaluation revealed no abnormalities. In the donor operation, the donor liver biopsy revealed expansion of the portal zone with lymphocytic infiltration and dense concentric fibrosis developed around a bile duct. These histological findings were identical to those of early-stage PSC; therefore, the LDLT was called off. The experience in this case suggests that preoperative liver biopsy may be useful to exclude first-degree relative donors with potential PSC prior to LDLT for PSC.
authors.affiliation: Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: S
authors.initials: S
authors.lastname: Kawachi
authors.forename: M
authors.initials: M
authors.lastname: Shimazu
authors.forename: K
authors.initials: K
authors.lastname: Hoshino
authors.forename: M
authors.initials: M
authors.lastname: Tanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Fuchimoto
authors.forename: H
authors.initials: H
authors.lastname: Obara
authors.forename: M
authors.initials: M
authors.lastname: Shinoda
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Akatsu
authors.forename: R
authors.initials: R
authors.lastname: Irie
authors.forename: M
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Morikawa
authors.forename: M
authors.initials: M
authors.lastname: Kitajima
mesh_terms: D000328:Adult; D001706:Biopsy; D015209:Cholangitis, Sclerosing / Q000601:surgery*; D005234:Fatty Liver / Q000473:pathology*; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D008099:Liver / Q000473:pathology*; D016031:Liver Transplantation / Q000379:methods* / Q000473:pathology; D019520:Living Donors; D016079:Refusal to Treat