Inhibition of human lipoprotein oxidation by morelloflavone and camboginol from Garcinia dulcis.
A biflavonoids, morelloflavone (1) and a prenyltated xanthone, camboginol (2), isolated from the fruits of Garcinia dulcis (Roxb.) Kurz., exhibited strong antioxidation effects in both Fe2+ -mediated and non-metal induced human low-density lipoprotein (LDL) oxidations. However, a well-known antioxidant, alpha-tocopherol (vitamin E), was found less potent than both compounds based on the same test systems.
Hutadilok-Towatana
Nongporn
N
Department of Biochemistry, Faculty of Science, Prince of Songkla University, Songkhla, Thailand. nongporn@psu.ac.th
Kongkachuay
Suyanee
S
Mahabusarakam
Wilawan
W
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000737:chemistry; D005638:Fruit / Q000737:chemistry; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013785:Thailand; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D044946:Biflavonoids; D005296:Ferrous Compounds; D008077:Lipoproteins, LDL; D013729:Terpenes; D017392:Thiobarbituric Acid Reactive Substances; C105620:morelloflavone; C020748:ferrous sulfate; C054597:garcinol