Does albendazole affect seizure remission and computed tomography response in children with neurocysticercosis? A Systematic review and meta-analysis.
A recent trial suggested that albendazole reduces seizures in adults with neurocysticercosis. There is still no consensus regarding optimal management of neurocysticercosis in children. The authors conducted a systematic review and meta-analysis to assess the efficacy of albendazole in children with neurocysticercosis, by searching the Cochrane Databases, MEDLINE, EMBASE, and LILACS. Three reviewers extracted data using an intent-to-treat analysis. Random effects models were used to estimate relative risks. Four randomized trials were selected for meta-analysis, and 10 observational studies were selected for qualitative review. The relative risk of seizure remission in treatment versus control was 1.26 (1.09, 1.46). The relative risk of improvement in computed tomography in these trials was 1.15 (0.97, 1.36). Review of observational studies showed conflicting results, likely owing to preferential administration of albendazole to sicker children.
Mazumdar
Maitreyi
M
Department of Neurology, Children's Hospital Boston, Boston, Massachusetts 02115, USA. maitreyi.mazumdar@childrens.harvard.edu
Pandharipande
Pari
P
Poduri
Annapurna
A
D015766:Albendazole / Q000627:therapeutic use*; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual / Q000706:statistics & numerical data; D006801:Humans; D020019:Neurocysticercosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed / Q000379:methods
D000977:Antiparasitic Agents; D015766:Albendazole