[Secondary osteoporosis. Glucocorticoid induced osteoporosis in childhood : prophylaxis and treatment].
Bone turnover rate during growth is extremely rapid. Bone growth is under the control of various hormonal environments. Long term administration of glucocorticoid in childhood induced not only osteoporosis but also growth failure via direct action on bone and cartilage and indirectly via hormonal derangements. Sex steroid is one of the important hormones for the bone mineral accrual and for cartilage maturation. Thus glucocorticoid usage during puberty results in irreversible derangements in bone health including bone growth and peak bone mass accrual. Recently bisphosphonates have been widely used in prophylaxis and treatment of the steroid induced osteoporosis in adult with large amount of evidences, which is largely unknown for the pediatric patients.
Tanaka
Hiroyuki
H
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Pediatrics.
D000293:Adolescent; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002118:Calcium / Q000627:therapeutic use; D002648:Child; D002986:Clinical Trials as Topic; D004164:Diphosphonates / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*; D014807:Vitamin D / Q000627:therapeutic use
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D005938:Glucocorticoids; D014807:Vitamin D; D002118:Calcium