[Therapy-resistant hypertension--the endocrinological view].
A significant percentage of patients with therapy-resistant high blood pressure have hormonal hypertension. This includes primary hyperaldosteronism due to an aldosterone-producing adenoma, or a bilateral adrenal hyperplasia, hypercortisolism caused by a tumor of the adrenals, or an ACTH-dependent form of Cushing's syndrome, as also excessive catecholamines caused by a pheochromocytoma or a paraganglioma. The diagnostic work-up includes screening tests for the basal hormone status in the serum and urine, together with confirmatory additional hormonal and imaging procedures in suspected cases, or to establish a differential diagnosis. In addition to surgical treatment, specific pharmacotherapeutic measures for the prevention or follow-up treatment of excess adrenal hormones are available.
Beuschlein
F
F
Medizinische Klinik Innenstadt, Ludwig-Maximilians-Universität München. felix.beuschlein@med.uni-muenchen.de
Reincke
M
M
D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000175:diagnosis; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis; D018246:Adrenocortical Adenoma / Q000150:complications / Q000175:diagnosis; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002395:Catecholamines / Q000097:blood*; D003480:Cushing Syndrome / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004351:Drug Resistance; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000175:diagnosis; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D010673:Pheochromocytoma / Q000150:complications / Q000175:diagnosis
D000959:Antihypertensive Agents; D002395:Catecholamines