title: POEMS syndrome: relapse after successful autologous peripheral blood stem cell transplantation.
abstract: We report a patient with POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) treated with high dose chemotherapy and auto-Peripheral Blood Stem Cell Transplantation (auto-PBSCT) who had a very good response with complete clinical remission. Seven years later, she relapsed and a new sclerotic bone lesion was found. To our knowledge, this is the first POEMS syndrome relapse after successful auto-PBSCT.
authors.affiliation: Division of Biochemistry and Genetics, IRCCS Foundation, C. Besta Neurological Institute, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Giglia
authors.forename: L
authors.initials: L
authors.lastname: Chiapparini
authors.forename: L
authors.initials: L
authors.lastname: Fariselli
authors.forename: T
authors.initials: T
authors.lastname: Barbui
authors.forename: C
authors.initials: C
authors.lastname: Ciano
authors.forename: M
authors.initials: M
authors.lastname: Scarlato
authors.forename: D
authors.initials: D
authors.lastname: Pareyson
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology*; D004358:Drug Therapy; D005260:Female; D006801:Humans; D010026:Osteosclerosis / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D016878:POEMS Syndrome / Q000503:physiopathology / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D016634:Radiosurgery; D012008:Recurrence; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A