Desferoxamine reverses neonatal iron-induced recognition memory impairment in rats.
We have previously demonstrated that rats given iron neonatally presented memory deficits. The aim of the present study was to evaluate the effect of desferoxamine, a metal chelating agent, on memory deficits in an iron overload model in rats. Male rats received vehicle or iron orally at postnatal days 12-14 and desferoxamine (30 or 300 mg/kg) in the adulthood. After desferoxamine treatment, they were trained in a novel-object recognition task. Iron-treated rats showed recognition memory impairments when compared to controls. Iron-treated rats that received desferoxamine 300 mg/kg, showed normal recognition memory, suggesting that desferoxamine can reverse recognition memory deficits associated with iron accumulation. Further research is required to examine whether the findings from animal models of iron overload have implications for humans.
de Lima
Maria N M
MN
Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University, 90619-900 Porto Alegre, RS, Brazil.
Presti-Torres
Juliana
J
Caldana
Fábio
F
Grazziotin
Manoela M
MM
Scalco
Felipe S
FS
Guimarães
Marcelo R
MR
Bromberg
Elke
E
Franke
Silvia I R
SI
Henriques
João A P
JA
Schröder
Nadja
N
D000818:Animals; D000831:Animals, Newborn; D003676:Deferoxamine / Q000627:therapeutic use*; D007501:Iron / Q000009:adverse effects*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D017262:Siderophores / Q000627:therapeutic use*
D018696:Neuroprotective Agents; D017262:Siderophores; D007501:Iron; D003676:Deferoxamine