title: Stereochemistry of pladienolide B.
abstract: Pladienolide B is a 12-membered macrolide isolated from Streptomyces platensis Mer-11107. It showed potent in vitro and in vivo antitumor activities and is a potential lead for novel antitumor agents. The absolute configurations at ten chiral centers were determined on the basis of spectral data of pladienolide B and its chemical transformation products.
authors.affiliation: Tsukuba Research Laboratories, Eisai Co., Ltd, Tokodai, Tsukuba, Ibaraki, Japan. n2-asai@hhc.eisai.co.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Asai
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kotake
authors.forename: Jun
authors.initials: J
authors.lastname: Niijima
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Taisuke
authors.initials: T
authors.lastname: Uehara
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakai
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D004852:Epoxy Compounds / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D018942:Macrolides; C522342:pladienolide B