Platelet-enriched fibrin glue and platelet-rich plasma in the repair of bone defects adjacent to titanium dental implants.
OBJECTIVE
The aim of this study was to compare the effects of platelet-enriched fibrin glue and platelet-rich plasma (PRP) on the repair of bone defects adjacent to titanium dental implants.


METHODS
In 6 mongrel dogs, 3 screw-shaped titanium dental implants per dog were placed into the osteotomy sites in the tibia. Before implantation, a standardized gap (2.0 mm) was created between the implant surface and the surrounding bone walls. Six gaps were left empty (control group), 6 gaps were filled with autogenous particulate bone mixed with PRP (PRP group), and 6 gaps were filled with autogenous particulate bone mixed with platelet-enriched fibrin glue (fibrin glue group).


RESULTS
After 6 weeks, the bone-implant contact was 59.7% in the fibrin glue group, 29.2% in the PRP group, and 10.2% in the control defects; this difference was statistically significant (P < .05).


CONCLUSIONS
Greater bone-implant contact was achieved with platelet-enriched fibrin glue than with PRP. The results indicate that platelet-enriched fibrin glue can induce a stronger peri-implant bone reaction than PRP in the treatment of bone defects adjacent to titanium dental implants.
You
Tae-Min
TM
Graduate Student, Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea.
Choi
Byung-Ho
BH
Zhu
Shi-Jiang
SJ
Jung
Jae-Hyung
JH
Lee
Seoung-Ho
SH
Huh
Jin-Young
JY
Lee
Hyun-Jung
HJ
Li
Jingxu
J
D000818:Animals; D015921:Dental Implants; D004285:Dogs; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D053657:Platelet-Rich Plasma; D013977:Tibia / Q000601:surgery; D014945:Wound Healing
D015921:Dental Implants; D015718:Fibrin Tissue Adhesive