[Effect of natural allergens exposure on serum concentration of soluble form of intercellular adhesion molecule 1 in patients with seasonal airway allergy].
Chronic inflammation is a feature of bronchial asthma and allergic rhinitis. Intercellular adhesion molecules, especially ICAM-1 and its soluble form sICAM-1 present in systemic liquids play an important role in allergic inflammation. The aim of this study was to assess the effect of natural pollen exposure to plants on serum sICAM-1 concentration in patients with different clinical expression of seasonal allergy and to determine the relation between concentrations of these molecules to clinical symptom score and nonspecific bronchial hyperresponsiveness (BHR).


METHODS
The study comprised 48 patients with isolated seasonal allergic rhinitis (SAR), 26 patients with seasonal asthma (SA) and 16 healthy volunteers. Serum s/CAM-1 concentration using an immunoenzymatic ELISA method and BHR to methacholine were measured twice, before grass season and during symptomatic period of SAR and SA. Clinical symptoms severity were evaluated by pointing method from patients diary cards.


RESULTS
The study revealed no differences in mean concentration of serum sLCAM-1 between patients with SAR and SA but significant increase of serum sICAM-1 level during natural allergen exposure in all patients was observed.


CONCLUSIONS
Serum concentration of sICAM-1 was not correlated to symptom score and BHR in both SAR and SA patients in and out of season.
Kroczyńska-Bednarek
Jadwiga
J
Uniwersytet Medyczny w Lodzi, Klinika Gruźlicy, Chorób i Nowotworów Płuc. jagoda.bednarek@poczta.fm
Pietrzkowicz
Magdalena
M
Górski
Paweł
P
Grzelewska-Rzymowska
Iwona
I
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D016535:Bronchial Hyperreactivity / Q000097:blood* / Q000453:epidemiology; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D005260:Female; D005541:Forced Expiratory Volume; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood* / Q000453:epidemiology; D012680:Sensitivity and Specificity; D012995:Solubility; D013147:Spirometry
D000485:Allergens; D015415:Biomarkers; D006634:Histamine H1 Antagonists; D018799:Intercellular Adhesion Molecule-1