Evaluation of polyethersulfone highflux hemodialysis membrane in vitro and in vivo.
A new hemodialysis membrane manufactured by a blend of polyethersulfone (PES) and polyvinylpyrrolidone (PVP) was evaluated in vitro and in vivo. Goat was selected as the experimental animal. The clearance and the reduction ratio after the hemodialysis of small molecules (urea, creatinine, phosphate) for the PES membrane were higher in vitro than that in vivo. The reduction ratio of beta(2)-microglobulin was about 50% after the treatment for 4 h. The biocompatibility profiles of the membranes indicated slight neutropenia and platelet adhesion at the initial stage of the hemodialysis. Electrolyte, blood gas, and blood biochemistry were also analyzed before and after the treatment. The results indicated that PES hollow fiber membrane had a potential widely use for hemodialysis.
Su
Bai-hai
BH
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, P.R. China.
Fu
Ping
P
Li
Qiu
Q
Tao
Ye
Y
Li
Zi
Z
Zao
Hui-sha
HS
Zhao
Chang-sheng
CS
D000818:Animals; D001672:Biocompatible Materials; D004573:Electrolytes / Q000097:blood; D006041:Goats; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones / Q000737:chemistry*; D013552:Swine / Q000097:blood
D001672:Biocompatible Materials; D004573:Electrolytes; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C022840:polyether sulfone; D011205:Povidone