title: Cranial leiomyosarcoma in an Epstein-Barr virus (EBV)-mismatched lung transplant recipient.
abstract: Leiomyosarcoma is a rare Epstein-Barr virus (EBV)-related complication of solid-organ transplantation. We report the case of a 19-year-old woman with cystic fibrosis who presented with protracted headaches 15 months after an EBV-mismatched bilateral sequential lung transplant. A parasagittal lesion was found on cranial magnetic resonance imaging; surgical resection revealed a leiomyosarcoma. We discuss treatment options of what is, to our knowledge, the first described case of a cranial leiomyosarcoma in a lung transplant recipient.
authors.affiliation: Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: Nadia J
authors.initials: NJ
authors.lastname: Chaves
authors.forename: Tom C
authors.initials: TC
authors.lastname: Kotsimbos
authors.forename: Mark A
authors.initials: MA
authors.lastname: Warren
authors.forename: Catriona A
authors.initials: CA
authors.lastname: McLean
authors.forename: Denis W
authors.initials: DW
authors.lastname: Spelman
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Williams
authors.forename: Greg I
authors.initials: GI
authors.lastname: Snell
authors.forename: Glen P
authors.initials: GP
authors.lastname: Westall
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000821:virology*; D003550:Cystic Fibrosis / Q000601:surgery; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000473:pathology / Q000821:virology*; D016040:Lung Transplantation / Q000009:adverse effects* / Q000276:immunology; D008279:Magnetic Resonance Imaging; D014775:Virus Activation / Q000502:physiology
chemical_list: D000914:Antibodies, Viral