Multicentric reticulohistiocytosis: a proliferation of macrophages with tropism for skin and joints, part I.
The authors present part I of a review of multicentric reticulohistiocytosis, a rare systemic proliferative disease of histiocytes of unknown cause. It is clinically characterized by cutaneous and mucosal nodules and by osteoarticular lesions. The disease occurs in outbreaks that progress in severity, with spontaneous regression, but usually leaving incapacitating arthritis and disfiguring facial lesions. The authors discuss the historical, epidemiologic, and clinical aspects of this disease.
Luz
Flávio Barbosa
FB
Sector of Dermatology, University Hospital HUCFF/UFRJ and School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. luzfb@globo.com
Gaspar
Neide Kalil
NK
Gaspar
Antonio Pedro
AP
Carneiro
Sueli
S
Ramos-e-Silva
Marcia
M
D001168:Arthritis / Q000000981:diagnostic imaging / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology*; D002465:Cell Movement; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D007596:Joints / Q000473:pathology*; D008264:Macrophages / Q000502:physiology*; D009092:Mucous Membrane / Q000473:pathology*; D011859:Radiography; D012867:Skin / Q000473:pathology*