title: Prevalence and common genotypes of HCV infection in Sudanese patients with hepatosplenic schistosomiasis.
abstract: A cross-sectional hospital based study was carried out at the National Center for Gastrointestinal and Liver Disease in Khartoum, Sudan to determine the prevalence, common genotypes and risk factors for hepatitis C virus infection in Sudanese patients with hepatosplenic schistosomiasis. A total of 176 patients with hepatosplenic schistosomiasis were tested for HCV antibodies and 4.5% of the samples were reactive. PCR was positive in 2.3% of cases and genotype 4 was the major genotype isolated with subtypes 4, 4e, and 4c/4d. It is concluded that HCV was of low seroprevalence in the study population and that parenteral antischistosomal therapy was not a significant risk factor in transmission of infection in the Sudan.
authors.affiliation: Department of Internal Medicine, University of Khartoum, Khartoum, Sudan. hmudawi@hotmail.com
authors.forename: H M Y
authors.initials: HM
authors.lastname: Mudawi
authors.forename: H M
authors.initials: HM
authors.lastname: Smith
authors.forename: I A
authors.initials: IA
authors.lastname: Fletcher
authors.forename: S S
authors.initials: SS
authors.lastname: Fedail
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology* / Q000821:virology; D018937:Hepatitis C Antibodies / Q000276:immunology; D006801:Humans; D008109:Liver Diseases, Parasitic / Q000150:complications; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012555:Schistosomiasis mansoni / Q000150:complications*; D016036:Seroepidemiologic Studies; D013158:Splenic Diseases / Q000150:complications; D013397:Sudan / Q000453:epidemiology
chemical_list: D018937:Hepatitis C Antibodies