title: The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS).
abstract: New findings lead to a revised understanding of the substrates' binding order, the role of the substrate as an activator, and the observed lag phase in the FDTS catalyzed reaction.
authors.affiliation: Department of Chemistry, The University of Iowa, Iowa City, IA, USA.
authors.forename: Anatoly
authors.initials: A
authors.lastname: Chernyshev
authors.forename: Todd
authors.initials: T
authors.lastname: Fleischmann
authors.forename: Eric M
authors.initials: EM
authors.lastname: Koehn
authors.forename: Scott A
authors.initials: SA
authors.lastname: Lesley
authors.forename: Amnon
authors.initials: A
authors.lastname: Kohen
mesh_terms: D005415:Flavins / Q000378:metabolism*; D009705:Nucleosides / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D013940:Thymidylate Synthase / Q000378:metabolism*
chemical_list: D005415:Flavins; D009705:Nucleosides; D010088:Oxidoreductases; D013940:Thymidylate Synthase