Effect of 1- and 10-day administration of tepoxalin on minimum alveolar concentration of isoflurane and sevoflurane in dogs.
Analgesics given preoperatively have the potential to decrease the amount of inhalant anesthetics required intraoperatively (i.e., to decrease the minimum alveolar concentration, or MAC, for the inhalant). Tepoxalin is an NSAID approved for the treatment of arthritis in dogs in the United States and, hence, could be administered to patients undergoing anesthesia. In this study, administration of a single dose or a 10-day course of tepoxalin did not affect the MAC for isoflurane or sevoflurane.
Crist
M A
MA
Department of Small Animal Clinical Sciences, Texas A & M University, College Station, TX 77843-4474, USA.
Matthews
N S
NS
Oberle
N L
NL
Pappas
C
C
D000280:Administration, Inhalation; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D004285:Dogs / Q000502:physiology*; D004347:Drug Interactions; D005260:Female; D007530:Isoflurane / Q000008:administration & dosage; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage; D011229:Preanesthetic Medication / Q000662:veterinary; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000378:metabolism; D011720:Pyrazoles / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D000077149:Sevoflurane; D016896:Treatment Outcome
D018685:Anesthetics, Inhalation; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008738:Methyl Ethers; D011720:Pyrazoles; D000077149:Sevoflurane; D007530:Isoflurane; C073135:tepoxalin