title: The effects of methylphenidate on the classroom behavior of elementary school-age children with cerebral palsy: a preliminary observational analysis.
abstract: High- and low-dose methylphenidate administration was evaluated prospectively for 3 elementary school-age children with cerebral palsy, cognitive impairments, and attention-deficit hyperactivity disorder (ADHD) symptoms using single-case, randomized, double-blind, placebo-controlled designs. An observational time sampling protocol was used to directly measure and quantify classroom behavior. Summary level analysis showed that (1) low-dose (0.3 mg/kg/dose) administration was associated with clinically significant (>50%) reductions in stereotyped and disruptive behavior relative to baseline and placebo conditions, (2) high-dose (0.5 mg/kg/dose) administration was associated with exacerbated amounts of stereotyped and disruptive behavior, and (3) no changes were directly observed for task-related behavior at either dose. Results are discussed with respect to previous research with methylphenidate administration and cerebral palsy, and the suggestion is made that further work using larger, randomly selected study samples with complementary measures of behavior and performance appears warranted.
authors.affiliation: Department of Educational Psychology, Burton Hall, 178 Pillsbury Drive SE, University of Minnesota, Minneapolis, MN 55455, USA. symon007@umn.edu
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Symons
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Tervo
authors.forename: Ockjean
authors.initials: O
authors.lastname: Kim
authors.forename: John
authors.initials: J
authors.lastname: Hoch
mesh_terms: D019958:Attention Deficit and Disruptive Behavior Disorders / Q000188:drug therapy / Q000209:etiology; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000188:drug therapy* / Q000503:physiopathology*; D002648:Child; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D019370:Observation; D012574:Schools; D012919:Social Behavior; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate