title: Stellettins L and M, cytotoxic isomalabaricane-type triterpenes, and sterols from the marine sponge Stelletta tenuis.
abstract: Two new isomalabaricane-type triterpenes, stellettins L (1) and M (2), and three new sterols (3-5) were isolated from the marine sponge Stelletta tenuis collected in the South China Sea. Chemical structures were established from spectroscopic data and comparison with known compounds. In addition, spectroscopic data reported for the known sterol 24-methylene-27-methylcholest-5-en-3beta-ol-7-one (6) were revised. Compounds 1 and 2 exhibited significant cytotoxic activity against stomach cancer (AGS) in vitro.
authors.affiliation: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Fengyang Road 415, Shanghai 200003, People's Republic of China.
authors.forename: Hou-wen
authors.initials: HW
authors.lastname: Lin
authors.forename: Zeng-lei
authors.initials: ZL
authors.lastname: Wang
authors.forename: Jiu-hong
authors.initials: JH
authors.lastname: Wu
authors.forename: Ning
authors.initials: N
authors.lastname: Shi
authors.forename: Hong-jun
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Wan-sheng
authors.initials: WS
authors.lastname: Chen
authors.forename: Susan L
authors.initials: SL
authors.lastname: Morris-Natschke
authors.forename: An-Shen
authors.initials: AS
authors.lastname: Lin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013261:Sterols; D014315:Triterpenes; C522140:stellettin L; C522141:stellettin M