title: A review of the management by hysterectomy of 25 cases of gestational trophoblastic tumours from March 1993 to January 2006.
abstract: We reviewed 25 cases of gestational trophoblastic tumours referred for surgical management from Charing Cross Hospital (the London centre for gestational trophoblastic disease [GTD]) over a 13-year period. The operation performed was total abdominal hysterectomy, with lymph node sampling in 9/25 (36%) women and bilateral salpingo-oophorectomy in 11/25 (44%) women. Radical hysterectomy and unilateral parametrectomy was required in 3/25 (12%) women. Three of 25 (12%) women failed to survive, i.e. the overall rate of survival was 88%. Management by hysterectomy of primary drug-resistant and relapse cases of GTD is a useful and safe adjunct to chemotherapy.
authors.affiliation: West London Gynaecological Cancer Centre, Hammersmith Hospital NHS Trust, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Doumplis
authors.forename: K
authors.initials: K
authors.lastname: Al-Khatib
authors.forename: K
authors.initials: K
authors.lastname: Sieunarine
authors.forename: I
authors.initials: I
authors.lastname: Lindsay
authors.forename: M
authors.initials: M
authors.lastname: Seckl
authors.forename: J
authors.initials: J
authors.lastname: Bridges
authors.forename: J R
authors.initials: JR
authors.lastname: Smith
mesh_terms: D000328:Adult; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary; D008197:Lymph Node Excision / Q000379:methods; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D011247:Pregnancy