A new Hantaan-like virus in rodents (Apodemus peninsulae) from Northeastern China.
Lung tissue samples of 76 Korean field mice (Apodemus peninsulae) collected from northeastern China bordering with Far East Russia and Korea were detected for hantavirus partial M-segment or entire S-segment sequences by RT-PCR and 481-nt mitochondrial DNA fragment of the rodents. Four A. peninsulae mice were found positive for partial M-segment of hantavirus. Sequence analyses of partial M-segment or/and entire S-segment of the hantaviruses revealed that three were closely related to Hantaan virus (HTNV) strain 76-118. One new variant of HTNV-like virus designated as "Jilin-AP06" was much different from other rodent-borne hantavirus from China, and clustered with Amur (AMR) virus strains, which represent a distinct genetic lineage. These findings imply that hantavirus Jililn-AP06 strain from A. peninsulae is a new record of rodent-borne AMR virus in China. A. peninsulae might be a natural carrier of two distinct hantaviruses, AMR virus and HTNV in China.
Jiang
Jia-Fu
JF
Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, PR China.
Zhang
Wen-Yi
WY
Yao
Kun
K
Wu
Xiao-Ming
XM
Zuo
Shu-Qing
SQ
Zhan
Lin
L
Zhang
Pan-He
PH
Cao
Wu-Chun
WC
D000818:Animals; D002681:China; D018063:Hantaan virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D008168:Lung / Q000821:virology; D051379:Mice; D008969:Molecular Sequence Data; D051189:Murinae / Q000821:virology*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
D012367:RNA, Viral