title: [Expression of chemokine like factor-1 in nephridial tissue of lupus nephritis].
abstract: OBJECTIVE
  To investigate the influence of chemokine like factor-1(CKLF-1) on the genesis and development of lupus nephritis.
  
  
  METHODS
  Immunohistochemistry stain was employed on the 34 lupus nephridial tissues and 10 nephridial tissues of control group. And light microscopy was applied to observe the percentage of CKLF-1 positive cells of renal gromerulus and tubule.
  
  
  RESULTS
  The percentages of CKLF-1 positive cells of renal gromerulus and tubule were 10.4%+/-1.5% and 48.9%+/-4.3% in the lupus nephritis group, and the percentages of control group were 4.6%+/-1.1% and 4.3%+/-0.9%. There was significant difference between 2 groups (P<0.01). And there was positive correlation between the percentage of CKLF-1 positive cells of renal gromerulus and tubule and lupus active index (r=0.74 and r=0.53, respectively, P<0.05).
  
  
  CONCLUSIONS
  CKLF-1 plays a role in the genesis and development of lupus nephritis.
authors.affiliation: Department of Nephrology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ji
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
authors.forename: Guo-ping
authors.initials: GP
authors.lastname: Yang
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Xie
mesh_terms: D000328:Adult; D018925:Chemokines / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry* / Q000473:pathology; D008181:Lupus Nephritis / Q000378:metabolism* / Q000473:pathology; D062792:MARVEL Domain-Containing Proteins; D008297:Male
chemical_list: C432676:CKLF protein, human; D018925:Chemokines; D062792:MARVEL Domain-Containing Proteins