title: In vivo activity of a novel polymeric guanidine in experimental skin infection with methicillin-resistant Staphylococcus aureus.
abstract: The in vivo efficacy of the novel polymeric guanidine AKACID Plus was evaluated in a guinea pig model of experimental skin infection with methicillin-resistant Staphylococcus aureus (MRSA). Topical application of AKACID Plus at concentrations of > or =0.5% was as effective as mupirocin 2% cream in the treatment of superficial skin infection with MRSA.
authors.affiliation: Department of Internal Medicine I, Division of Infectious Diseases and Chemotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
authors.forename: Christina
authors.initials: C
authors.lastname: Kratzer
authors.forename: Selma
authors.initials: S
authors.lastname: Tobudic
authors.forename: Karin
authors.initials: K
authors.lastname: Macfelda
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Graninger
authors.forename: Apostolos
authors.initials: A
authors.lastname: Georgopoulos
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006168:Guinea Pigs; D008297:Male; D016106:Methicillin Resistance; D016712:Mupirocin / Q000494:pharmacology; D011108:Polymers / Q000627:therapeutic use*; D012867:Skin / Q000382:microbiology; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: C512857:AKACID Plus; D000900:Anti-Bacterial Agents; D006146:Guanidines; D011108:Polymers; D016712:Mupirocin