title: Androgenic juvenile granulosa cell tumor of the ovary with cystic presentation: a case report.
abstract: Granulosa cell tumors account for approximately 1-2% of all ovarian tumors. There are two types: adult granulosa cell tumor and juvenile granulosa cell tumor. Juvenile granulosa cell tumors constitute 5% of this histological subtype, and the prognosis is good because the majority present as Stage I tumors. The treatment can consist of conservative surgery. Androgen production is rare and produces virilization in women. These tumors are usually solid or predominantly solid. We describe the case of a 13-year-old girl with androgenic manifestations and increased abdominal size. Her plasma testosterone level was elevated. A left adnexal cyst (14.4 x 9.1 x 9.7 cm) was revealed at pelvic ultrasonography. The patient underwent an exploratory laparotomy, revealing a left ovarian cystic tumor. Diagnosis was juvenile granulosa cell tumor.
authors.affiliation: Research Institute of Oncology (IPON)/Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro (UFTM), Uberaba-MG, Brazil.
authors.forename: R S
authors.initials: RS
authors.lastname: Nomelini
authors.forename: A M R
authors.initials: AM
authors.lastname: Micheletti
authors.forename: S J
authors.initials: SJ
authors.lastname: Adad
authors.forename: E F C
authors.initials: EF
authors.lastname: Murta
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000293:Adolescent; D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D019326:17-alpha-Hydroxyprogesterone