Synthesis of rigid homo- and heteroditopic nucleobase-terminated molecules incorporating adenine and/or thymine.
A series of homo- and heteroditopic thymine- and/or adenine-terminated molecules incorporating rigid aryl or oligo(phenylene ethynylene) linkers has been efficiently synthesized. The key steps involved in the synthesis are the construction of the N-arylated nucleobases using the Chan-Lam-Evans-modified Ullman coupling and their further elaboration using the Sonogashira coupling. Furthermore, the synthesis of a rigid tripodal thymine derivative is reported.
Jacobsen
Mikkel F
MF
Centre for DNA Nanotechnology, Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark.
Andersen
Casper S
CS
Knudsen
Martin M
MM
Gothelf
Kurt V
KV
D000225:Adenine / Q000737:chemistry*; D009711:Nucleotides / Q000138:chemical synthesis*; D013941:Thymine / Q000737:chemistry*
D009711:Nucleotides; D000225:Adenine; D013941:Thymine