title: Effects of short-term moderate alcohol administration on oxidative stress and nutritional status in healthy males.
abstract: The effects of moderate amounts of different alcoholic beverages on oxidative stress and nutritional parameters were investigated in 40 healthy subjects. Ethanol 40 g/day was administered at the two main meals for 30 days by beer (group A), wine (group B) or spirit (group C); controls (group D) maintaned abstinence. Malondyaldeide (MDA), adenosine-triphosphate (ATP), reduced-glutathione (GSH), E-vitamin and nutritional status were evaluated at the start (T0) and the end (T1) of the study. At T1 controls did not present significant changes in the assessed parameters, while a significant increase of malondyaldeide (MDA) and a significant decrease of reduced-glutathione and E-vitamin in group A, B and C and of ATP in group C were observed. Fat mass (FM) increased slightly in group A and B and decreased in group C. Ethanol decreased antioxidant parameters and increased lipoperoxidation parameters. However some of these changes appeared attenuated when ethanol was consumed in beer or wine. Finally, short-term moderate ethanol intake appeared to influence the FM, although it was not able to significantly affect nutritional or body composition.
authors.affiliation: Institutes of Internal Medicine, Catholic University of Rome, L.go A. Gemelli 8, I-00168, Rome, Italy. g.addolorato@rm.unicatt.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Addolorato
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Leggio
authors.forename: Veronica
authors.initials: V
authors.lastname: Ojetti
authors.forename: Esmeralda
authors.initials: E
authors.lastname: Capristo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gasbarrini
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini
mesh_terms: D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D000428:Alcohol Drinking; D000434:Alcoholic Beverages; D001515:Beer; D015992:Body Mass Index; D000431:Ethanol / Q000008:administration & dosage*; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009752:Nutritional Status / Q000187:drug effects*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D014810:Vitamin E / Q000097:blood; D014920:Wine
chemical_list: D014810:Vitamin E; D000431:Ethanol; D008315:Malondialdehyde; D000255:Adenosine Triphosphate; D005978:Glutathione