title: Irreversible cell-cycle transitions are due to systems-level feedback.
abstract: The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation of certain regulatory proteins. We argue that irreversible transitions in the cell cycle (or in any other molecular control system) cannot be attributed to a single molecule or reaction, but that they derive from feedback signals in reaction networks. This systems-level view of irreversibility is supported by many experimental observations.
authors.affiliation: Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. bela.novak@bioch.ox.ac.uk
authors.forename: Bela
authors.initials: B
authors.lastname: Novak
authors.forename: John J
authors.initials: JJ
authors.lastname: Tyson
authors.forename: Bela
authors.initials: B
authors.lastname: Gyorffy
authors.forename: Attila
authors.initials: A
authors.lastname: Csikasz-Nagy
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D004261:DNA Replication; D025461:Feedback, Physiological; D006801:Humans; D008954:Models, Biological
chemical_list: D018797:Cell Cycle Proteins