The growing applications of click chemistry.
Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy relies mainly upon the construction of carbon-heteroatom bonds using spring-loaded reactants. Its growing number of applications are found in nearly all areas of modern chemistry from drug discovery to materials science. The copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.
Moses
John E
JE
Department of Pharmaceutical & Biological Chemistry, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK WC1N 1AX. john.moses@pharmacy.ac.uk
Moorhouse
Adam D
AD
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003300:Copper / Q000737:chemistry; D003432:Cross-Linking Reagents; D015195:Drug Design; D014230:Triazoles / Q000737:chemistry
D000480:Alkynes; D001386:Azides; D003432:Cross-Linking Reagents; D014230:Triazoles; D003300:Copper