Preparation and characterization of rapamycin-loaded PLGA coating stent.
In this study, using polylactic acid-co-glycolic acid (PLGA) with a molecular weight of 95,800 Da as drug carrier, three dose (low, moderate, high) rapamycin-eluting stents and the corresponding coating films were prepared. The pre- and post-expansion morphology of the rapamycin-eluting stent was examined by scanning electron microscopy (SEM), indicating that the coating was very smooth and uniform. The coating had the ability to withstand the compressive and tensile strains imparted without cracking from the stent during expansion process. There were many voids on stent coating surface after released for 18 days in release medium. The thermodynamics data of the stent coating film measured by differential scanning calorimetry (DSC) showed a lack of measurable solubility of rapamycin in the PLGA matrix. The release behavior of rapamycin from stent surface had a two phase release profile with a burst release period of about 2 days, followed by a sustained and slow release phase. The mass loss behavior of PLGA appeared linear throughout most of the degradation period, corresponding to an approximately constant mass loss rate. The platelet adhesion tests showed that the rapamycin-eluting films may have a good blood compatibility compared with control samples. Take into these results account, this novel rapamycin-eluting may be a good candidate to resolve in-stent restenosis.
Pan
C J
CJ
Key Lab for Advanced Technologies of Materials of Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China. swjtupcj@163.com
Tang
J J
JJ
Weng
Y J
YJ
Wang
J
J
Huang
N
N
D020341:Absorbable Implants; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics; D002404:Catheterization / Q000295:instrumentation; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D054855:Drug-Eluting Stents; D006801:Humans; D019344:Lactic Acid / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D008422:Materials Testing; D008954:Models, Biological; D010973:Platelet Adhesiveness; D011100:Polyglycolic Acid / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D020123:Sirolimus / Q000737:chemistry / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D020123:Sirolimus