title: Potentialities of silica/alginate nanoparticles as hybrid magnetic carriers.
abstract: The possibility to associate traditional bio-organic capsules, such as polymer nanoparticles or liposomes, with silica has been recently demonstrated, opening the route to the design of novel nanocomposites that exhibit promising properties as drug carriers. In this context, we describe here the elaboration of silica/alginate nanoparticles incorporating magnetic iron oxide colloids and fluorescent carboxy-fluoroscein. These nanocomposites were characterized by electron microscopy, X-ray diffraction and magnetic measurements. The release of the fluorophore was investigated in vitro and was demonstrated to occur in 3T3 fibroblast cells. Further grafting of organic moieties on particle surface is also described. These data suggest that hybrid nanoparticles are flexible platforms for the developments of multi-functional bio-capsules.
authors.affiliation: Chimie de la Matière Condensée de Paris, CNRS-UMR 7574, Université Pierre et Marie Curie, 4 Place Jussieu, 75252 Paris Cedex 05, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Boissière
authors.forename: Joachim
authors.initials: J
authors.lastname: Allouche
authors.forename: Corinne
authors.initials: C
authors.lastname: Chanéac
authors.forename: Roberta
authors.initials: R
authors.lastname: Brayner
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Devoisselle
authors.forename: Jacques
authors.initials: J
authors.lastname: Livage
authors.forename: Thibaud
authors.initials: T
authors.lastname: Coradin
mesh_terms: D016475:3T3 Cells; D000464:Alginates; D000818:Animals; D003102:Colloids; D004337:Drug Carriers / Q000737:chemistry*; D005347:Fibroblasts / Q000378:metabolism; D005452:Fluoresceins / Q000737:chemistry / Q000493:pharmacokinetics; D005456:Fluorescent Dyes / Q000737:chemistry / Q000493:pharmacokinetics; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D008280:Magnetics; D051379:Mice; D008854:Microscopy, Electron; D053758:Nanoparticles; D012822:Silicon Dioxide; D014961:X-Ray Diffraction
chemical_list: D000464:Alginates; D003102:Colloids; D004337:Drug Carriers; D005452:Fluoresceins; D005456:Fluorescent Dyes; D006603:Hexuronic Acids; C024098:6-carboxyfluorescein; D012822:Silicon Dioxide; D020723:Glucuronic Acid