title: Treatment leading to dramatic recovery in acute hemorrhagic leukoencephalitis.
abstract: The clinical course, neuroimaging, neuropathological features, and management of a 7-year-old girl with acute hemorrhagic leukoencephalitis are reported. Treatment with subtotal bifrontal craniectomies for symptoms of imminent uncal herniation followed by high-dose corticosteroid therapy was associated with dramatic clinical recovery. This report highlights the utility of aggressive intervention in acute hemorrhagic leukoencephalitis, an otherwise fatal disorder.
authors.affiliation: Department of Pediatrics, Divisions of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Eric T
authors.initials: ET
authors.lastname: Payne
authors.forename: James T
authors.initials: JT
authors.lastname: Rutka
authors.forename: Tommy K
authors.initials: TK
authors.lastname: Ho
authors.forename: William C
authors.initials: WC
authors.lastname: Halliday
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Banwell
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002648:Child; D003399:Craniotomy / Q000379:methods; D005260:Female; D006801:Humans; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000503:physiopathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging / Q000379:methods; D020127:Recovery of Function / Q000502:physiology*
chemical_list: D000305:Adrenal Cortex Hormones