[Neutrophils' contribution to ischaemia and reperfusion injury in liver].
Neutrophils are cells which induce liver injury due to ischaemia and reperfusion. They are active especially in the later phase of reperfusion (> 6 hrs) since they gather in the liver and release mediators damaging hepatocytes directly. Inflow ofneutrophils into the liver is possible due to chemotaxia which involves, among others, chemokines CXC (interleukin-8 and its counterparts). Neutrophils' ability to induce chemotaxia is determined by their specific glycoprotein receptors in cell membranes. Neutrophils contribute to ischaemia/reperfusion liver injury because they adhere to vessel endothelium, cross the wall of hepatic microcirculation vessels and adhere to hepatocytes. Selectins play a crucial role in neutrophils' contact with endothelial cells, and ICAM-1, predominantly in their adhesion to hepatocytes. Also beta2-integrin and Mac-1 play essential role. Neutrophils damage hepatocytes by realising proteases, free radicals, TNF-alpha, TGF-beta and leucotrien. Neutrophils together with endothelial cells also disturb the hepatic microcirculation.
Helewski
Krzysztof J
KJ
Z Katedry i Zakładu Histologii i Embriologii w Zabrzu Rokitnicy.
Kowalczyk-Ziomek
Grazyna I
GI
Konecki
Janusz
J
D018821:CD18 Antigens / Q000378:metabolism; D019743:Chemokines, CXC / Q000276:immunology; D022781:Hepatocytes / Q000276:immunology / Q000473:pathology; D006801:Humans; D007511:Ischemia / Q000276:immunology / Q000473:pathology*; D008099:Liver / Q000098:blood supply* / Q000378:metabolism; D008107:Liver Diseases / Q000276:immunology* / Q000473:pathology*; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000276:immunology / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D018821:CD18 Antigens; D019743:Chemokines, CXC; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha