title: [Meta-analysis on the association of Myocilin Q368X mutation and primary open angle glaucoma].
abstract: OBJECTIVE
  To study the association between Myocilin (MYOC) Gln368STOP mutation and primary open angle glaucoma (POAG) by means of Meta-analysis.
  
  
  METHODS
  Odds ratios (OR) of MYOC Gln368STOP genotype distributions in POAG patients verse the controls were analyzed. All the relevant reported studies were identified. Poor-qualified studies were eliminated, and the risk of publication bias was excluded. Meta-analysis software, RevMan 4.2, was applied for investigating heterogeneity among individual studies and summarizing the effects across studies.
  
  
  RESULTS
  A total of 3077 POAG cases and 2063 controls from 11 studies were included. No heterogeneity among these studies was noticed (P = 0.79). The pooled OR (with 95% CI) of MYOC Gln368STOP in POAG cases versus that in the controls was 6.01 (2.57 - 14.04, P < 0.01).
  
  
  CONCLUSIONS
  MYOC Gln368STOP mutation might be associated with the increased risk of POAG and is one of its risk factors.
authors.affiliation: Department of Ophthalmology, Daping Hospital, Third Military Medical University, Chongqing, China. tingliu1597@126.com
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Xiang-Ge
authors.initials: XG
authors.lastname: He
mesh_terms: D003598:Cytoskeletal Proteins / Q000235:genetics*; D005136:Eye Proteins / Q000235:genetics*; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D009154:Mutation; D000099179:Myocilin
chemical_list: D003598:Cytoskeletal Proteins; D005136:Eye Proteins; D006023:Glycoproteins; D000099179:Myocilin