title: Extended-release formulations in epilepsy.
abstract: In the past years, the extended-release antiepileptic drug formulations have been developed and then approved for the treatment of many types of epilepsy. Among these extended-release formulations of antiepileptic drugs, the main drugs are valproic acid, carbamazepine, and phenytoin. This review analyzes the chemical and structural characteristics of the extended-release formulations of these 3 antiepileptic drugs, analyzing their bioequivalence and the studies about their clinical use. The results of these studies are encouraging and suggest a good tolerability and efficacy of these extended-release formulations, although larger studies are needed.
authors.affiliation: Department of Medicine, Section of Pediatrics, University of Chieti, Italy. averrott@unich.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Verrotti
authors.forename: Carmela
authors.initials: C
authors.lastname: Salladini
authors.forename: Giovanna
authors.initials: G
authors.lastname: Di Marco
authors.forename: Floriana
authors.initials: F
authors.lastname: Pisciella
authors.forename: Francesco
authors.initials: F
authors.lastname: Chiarelli
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans
chemical_list: D000927:Anticonvulsants; D003692:Delayed-Action Preparations