Structurally-defined direct C-magnesiation and C-zincation of N-heterocyclic aromatic compounds using alkali-metal-mediated metallation.
Demonstrating direct synergic "low polarity metallation", 1-methylindole is C-magnesiated by (TMEDA)(2).Na(2)MgBu(4) and C-zincated by (TMEDA).Na((t)Bu)(TMP)Zn((t)Bu), and 1-methylpyrrole is C-zincated by the same reagent, with all three metal products successfully crystallographically characterised.
Conway
Ben
B
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK G1 1XL.
Hevia
Eva
E
Kennedy
Alan R
AR
Mulvey
Robert E
RE