title: Nitazoxanide in the treatment of Ascaris lumbricoides in a rural zone of Colima, Mexico.
abstract: Intestinal parasites in Mexico are an endemic problem. A study was conducted in children, teenagers and adults in a rural community in Colima, Mexico to examine the prevalence and intensity of Ascaris lumbricoides infection and to evaluate the parasitological and clinical efficacy of nitazoxanide (NTZ). Two hundred and eighty children, teenagers and adults participated in this study. Parasitological diagnosis from faeces was confirmed by three consecutive stool samples using the floatation concentration Faust method. Egg counts were performed as described by the Kato-Katz technique before and after treatment. A questionnaire was systematically applied to obtain information about socio-economic status and hygienic habits. One hundred and six participants (38%) were diagnosed as harbouring intestinal parasites, and 86 of them (81%) were infected with A. lumbricoides. All patients with ascariasis infections underwent a complete physical examination before and after NTZ treatment. NTZ resolved 88% of the ascariasis cases, with a 89% clinical efficacy, and there was a 97.5% reduction in the levels of morbidity. The most intense infections for A. lumbricoides were found in housewives, and statistically significant associations were found between ascariasis and the absence of drainage and living in houses with dirt floors.
authors.affiliation: Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: M L
authors.initials: ML
authors.lastname: Galvan-Ramirez
authors.forename: N
authors.initials: N
authors.lastname: Rivera
authors.forename: M E
authors.initials: ME
authors.lastname: Loeza
authors.forename: X
authors.initials: X
authors.lastname: Avila
authors.forename: J
authors.initials: J
authors.lastname: Acero
authors.forename: R
authors.initials: R
authors.lastname: Troyo
authors.forename: R
authors.initials: R
authors.lastname: Bernal
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D001196:Ascariasis / Q000188:drug therapy* / Q000453:epidemiology; D017164:Ascaris lumbricoides; D002648:Child; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy* / Q000453:epidemiology; D008800:Mexico / Q000453:epidemiology; D009574:Nitro Compounds; D015995:Prevalence; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D000977:Antiparasitic Agents; D009574:Nitro Compounds; D013844:Thiazoles; C041747:nitazoxanide