Inhaled iloprost for severe persistent pulmonary hypertension of the newborn.
The authors report one case of persistent pulmonary hypertension that had hypoxia although receiving treatment with high frequency oscillation, inotropic drugs, blood transfusion, and oral sildenafil for pulmonary vasodilatation. The patient developed hypotension after two doses of oral sildenafil and no response to high dose of inotropic drugs. So aerosolized iloprost was given via endotracheal tube and oxygen saturation improved within 10 minutes. Oxygen was weaned at 36 hours after treatment with this drug and no any side effect was found.
Chotigeat
Uraiwan
U
Neonatal Unit, Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok 10400, Thailand.
Jaratwashirakul
Santiwan
S
D005260:Female; D006612:High-Frequency Ventilation; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D016285:Iloprost / Q000008:administration & dosage*; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D010547:Persistent Fetal Circulation Syndrome / Q000188:drug therapy* / Q000628:therapy; D010879:Piperazines / Q000009:adverse effects; D011687:Purines / Q000009:adverse effects; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000009:adverse effects; D017211:Treatment Failure; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D016285:Iloprost