Development of a novel neodymium compound for in vivo fluorescence imaging.
We developed a novel fluorescent probe that contains the neodymium(III) complex moiety and fluorescein moiety. This probe can emit long-lived near-infrared luminescence derived from a Nd ion through excitation of the fluorescein moiety with visible light (lambda(ex) = 488 nm, lambda(em) = 880 nm, lifetime = 2.3 micros). These results indicate the possibility of the probe as a candidate for in vivo fluorescence molecular imaging.
Aita
Kazuki
K
Department of Patho-functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.
Temma
Takashi
T
Kuge
Yuji
Y
Saji
Hideo
H
D006863:Hydrogen-Ion Concentration; D007091:Image Processing, Computer-Assisted; D049449:Luminescence; D015394:Molecular Structure; D009354:Neodymium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012996:Solutions / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000295:instrumentation / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation / Q000379:methods; D013997:Time Factors; D014867:Water / Q000737:chemistry
D009942:Organometallic Compounds; D012996:Solutions; D014867:Water; D009354:Neodymium