Effectiveness of recombinant activated factor VII (rFVII a) for controlling intractable postpartum bleeding: report of two cases and literature review.
BACKGROUND
Recombinant activated factor VII is used for the treatment in patients with inherited or acquired hemophilia with inhibitors and congenital factor VII deficiencies.


OBJECTIVE
Using recombinant activated factor VII in primary postpartum hemorrhage.


METHODS
Two cases of women who had postpartum hemorrhage and were treated with recombinant activated factor VII after all conventional treatment failed.


RESULTS
The intractable hemorrhage stopped after treatment with recombinant activated factor VII CONCLUSION: The present report showed that massive postpartum hemorrhage that failed to all procedures was controlled successfully by recombinant activated factor VII.
Jirapinyo
Mayuree
M
Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University Rama VI Rd, Bangkok 10400, Thailand. ramjy@mahidol.ac.th
Manonai
Jittima
J
Herabutya
Yongyoth
Y
Chuncharunee
Suporn
S
D000328:Adult; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000188:drug therapy* / Q000517:prevention & control; D011247:Pregnancy; D011994:Recombinant Proteins / Q000627:therapeutic use*; D017211:Treatment Failure; D016896:Treatment Outcome
D011994:Recombinant Proteins; D015942:Factor VIIa