Antibacterial diterpenoids from Jatropha podagrica Hook.
Japodagrin (1) and japodagrone (2), two macrocylic diterpenoids possessing lathyrane and jatrophane skeletons, respectively, have been isolated from the root of Jatropha podagrica Hook. Four other diterpenoids (3-6) were also isolated from this plant. The structures of these compounds were elucidated on the basis of NMR and HRMS analysis, and by spectral comparisons. The compounds displayed antibacterial activity against some gram-positive bacteria.
Aiyelaagbe
Olapeju O
OO
Department of Chemistry, University of Ibadan, Ibadan, Nigeria. oaiyelaagbe@yahoo.com
Adesogan
Kayode
K
Ekundayo
Olusegun
O
Gloer
James B
JB
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031286:Jatropha / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D004224:Diterpenes