[Correction of oxidative stress in the experimental thermal burn of the skin].
The white breedless rats have been investigated in conditional reflex activity restoration dynamics, exercise tolerance and prominence of oxidative stress after local burn injury of skin and effectiveness of Plaferon use, administered in the first three days after burn injury modeling. One day before administration the background values and the following dynamics of indexes on the first, third and fifth days were recorded. Tolerance exercise has been much higher in the group of animals receiving the Plafreon during the whole period of observation, but the prominence of oxidative stress has been lower than in the group of animals receiving no treatment. The use of the Plaferon has resulted in the improvement of the functional condition of animals, correlated with the level of oxidative stress change indexes.
Vadachkoriia
E O
EO
Iashvili
B P
BP
Matsaberidze
G Sh
GSh
Belikov
Iu N
IuN
Benashvili
L G
LG
D000818:Animals; D002056:Burns / Q000188:drug therapy*; D005260:Female; D009479:Neuropeptides / Q000494:pharmacology / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000293:injuries
D009479:Neuropeptides; C091912:plaferon