Evaluation of three antimicrobial regimens used as metaphylaxis in stocker calves at high risk of developing bovine respiratory disease.
A total of 894 calves at high risk for bovine respiratory disease were processed at two sites and randomly assigned to receive one of three antimicrobial metaphylactic regimens to determine if a two-drug regimen offered any advantage over the more conventional one-course regimens. On arrival, calves received either a two-course regimen of ceftiofur crystalline free acid (CCFA) followed by tulathromycin 8 days later (Group 1) or a one-course regiment of CCFA (Group 2) or tilmicosin (Group 3). At Site A, morbidity was significantly lower (52%) in Group 1 than in Group 2 (76.3%) and Group 3 (78.4%). At Site B, morbidity was significantly lower in Group 1 (2.6%) than in Group 2 (9.4%) and Group 3 (7.2%).
Step
D L
DL
Department of Veterinary Clinical Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Engelken
Terry
T
Romano
Cristina
C
Holland
Ben
B
Krehbiel
Clint
C
Johnson
John C
JC
Bryson
W Lawrence
WL
Tucker
Cassius M
CM
Robb
Edward J
EJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D048090:Bovine Respiratory Disease Complex / Q000401:mortality / Q000517:prevention & control*; D002417:Cattle; D002511:Cephalosporins / Q000627:therapeutic use*; D004187:Disaccharides / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D008297:Male; D012307:Risk Factors; D016896:Treatment Outcome; D018942:Macrolides
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004187:Disaccharides; D006571:Heterocyclic Compounds; C053503:ceftiofur; C485204:tulathromycin; D018942:Macrolides