title: Synthesis, spectroscopic and cytotoxic studies of biologically active new schiff bases derived from p-nitrobenzaldehyde.
abstract: Thirteen new Schiff bases derived from p-nitrobenzaldehyde were synthesized by condensation with the appropriate amines. An unusual reduction of the p-nitrobenzaldehyde to the corresponding alcohol was also observed in one of the reactions. The structures of the compounds were identified using spectroscopic techniques. Cytotoxicity for the titled compounds was studied against Brine Shrimp, used as the test animal.
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
authors.forename: Amjid
authors.initials: A
authors.lastname: Iqbal
authors.forename: Hamid Latif
authors.initials: HL
authors.lastname: Siddiqui
authors.forename: Chaudhary Muhammad
authors.initials: CM
authors.lastname: Ashraf
authors.forename: Mujahid Hussain
authors.initials: MH
authors.lastname: Bukhari
authors.forename: Chaudhary Muhammad
authors.initials: CM
authors.lastname: Akram
mesh_terms: D000588:Amines / Q000737:chemistry; D000818:Animals; D001156:Artemia / Q000187:drug effects*; D001547:Benzaldehydes / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology*; D018675:Toxicity Tests
chemical_list: D000588:Amines; D001547:Benzaldehydes; D012545:Schiff Bases; C029915:4-nitrobenzaldehyde