Chromosome instability and translocation t(11;18) in primary gastric marginal zone B-cell lymphoma of MALT-type.
The prognosis for patients with mucosa-associated lymphoid tissue (MALT) lymphomas is good; these tumours have usually an indolent course with overall survival rates that are greater than 80% at 5-year, but some rare cases with histological transformation in aggressive diffuse large cell lymphoma have also been diagnosed. Here, we present cytogenetic results on endoscopic bioptic material of 42 cases of primary gastric extranodal marginal zone B-cell lymphoma (EMZL) using fluorescence in situ hybridization (FISH) approach with API2, MALT1 and centromeric probes for chromosome 3 and 18, and their impact on the clinical outcome.
Tibiletti
Maria Grazia
MG
Anatomic Pathology Unit, University of Insubria, Ospedale di Circolo, Varese, Italy. mgtibiletti@hotmail.com
Milani
Katia
K
Martin
Vittoria
V
Zucca
Emanuele
E
Motta
Teresio
T
Cortelazzo
Sergio
S
Pinotti
Graziella
G
Mazzucchelli
Luca
L
Pruneri
Giancarlo
G
Martinelli
Giovanni
G
Barbazza
Renzo
R
Capella
Carlo
C
Bertoni
Francesco
F
D001706:Biopsy; D002503:Centromere; D043171:Chromosomal Instability; D002880:Chromosomes, Human, Pair 11; D002887:Chromosomes, Human, Pair 18; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D008297:Male; D015335:Molecular Probes; D015514:Oncogene Proteins, Fusion / Q000032:analysis; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology; D015996:Survival Rate; D014178:Translocation, Genetic; D016896:Treatment Outcome
C415943:API2-MALT1 fusion protein, human; D015335:Molecular Probes; D015514:Oncogene Proteins, Fusion