title: Hypertrophic mononeuropathy.
abstract: Hypertrophic localized mononeuropathy is a condition that comes to clinical attention as a painless focal swelling of a peripheral nerve in an arm or leg and is associated with a slow but progressive loss of motor and sensory function. Whether the proliferation of perineurial cells is neoplastic or degenerative--an ongoing controversy among nerve pathologists--for some patients resection of the involved portion of a nerve with autologous interposition grafting results in better functional outcome than allowing disease to follow its natural course. Patients with a painless focal enlargement of a nerve associated with progressive weakness and/or sensory loss may benefit from surgery for resection and grafting.
authors.affiliation: University of Southern California Keck School of Medicine, Department of Neurological Surgery, Los Angeles, California, USA. jpgruen@usc.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Gruen
authors.forename: David G
authors.initials: DG
authors.lastname: Kline
mesh_terms: D006801:Humans; D006984:Hypertrophy / Q000175:diagnosis / Q000601:surgery; D020422:Mononeuropathies / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D010525:Peripheral Nerves / Q000473:pathology* / Q000601:surgery*