title: Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population.
abstract: Recent genetic studies for osteoarthritis (OA) have been focused on ASPN, the gene encoding asporin, where aspartic acid (D)-repeat polymorphisms are associated with OA in several ethnic groups. The purpose of the present study is to further examine the association of the D-repeat polymorphism in a Han Chinese population. The D-repeat polymorphism was genotyped in 354 knee OA patients (257 women and 97 men) who suffered from primary symptomatic knee OA with radiographic confirmation, and the association of the repeat with various clinical parameters was examined. The age at onset (years) in patients with the D14 allele (mean: 51.9, SD: 8.5) was younger than that those without the D14 allele (mean: 54.9, SD: 10.9) (P = 0.023). Survival analysis showed D14 was significantly associated with age at onset of OA (P = 0.004 in the dominant model). The average age at onset of patients with the D13/D13 genotype (mean: 56.1, SD: 11.1) was older than those without the D13/D13 genotype (mean: 53.0, SD: 9.9) (P = 0.013). Our study further highlighted the significance of asporin in OA.
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital, affiliated to Medical School of Nanjing University, Zhongshan Road 321, Nanjing, 210008, Jiangsu, China.
authors.forename: Dongquan
authors.initials: D
authors.lastname: Shi
authors.affiliation: Laboratory for Statistical Analysis, SNP Research Center, Riken, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital, affiliated to Medical School of Nanjing University, Zhongshan Road 321, Nanjing, 210008, Jiangsu, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Dai
authors.affiliation: Department of Pathology, Medical School of Nanjing University, Nanjing, China.
authors.forename: Long
authors.initials: L
authors.lastname: Yi
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital, affiliated to Medical School of Nanjing University, Zhongshan Road 321, Nanjing, 210008, Jiangsu, China.
authors.forename: Jianghui
authors.initials: J
authors.lastname: Qin
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital, affiliated to Medical School of Nanjing University, Zhongshan Road 321, Nanjing, 210008, Jiangsu, China.
authors.forename: Dongyang
authors.initials: D
authors.lastname: Chen
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital, affiliated to Medical School of Nanjing University, Zhongshan Road 321, Nanjing, 210008, Jiangsu, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Pathology, Medical School of Nanjing University, Nanjing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Laboratory for Bone and Joint Diseases, Riken, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital, affiliated to Medical School of Nanjing University, Zhongshan Road 321, Nanjing, 210008, Jiangsu, China. qingj@nju.edu.cn.
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D001224:Aspartic Acid / Q000737:chemistry / Q000235:genetics*; D002681:China / Q000208:ethnology; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000235:genetics*; D011110:Polymorphism, Genetic; D020449:Repetitive Sequences, Amino Acid / Q000235:genetics
chemical_list: C439889:ASPN protein, human; D016326:Extracellular Matrix Proteins; D001224:Aspartic Acid