A chemo- and regio-selective three-component dihydropyrimidinone synthesis.
A selective three-component coupling, involving co-condensation of aldehyde pairs with substituted ureas under Lewis acid catalysis, provides rapid access to highly functionalised dihydropyrimidinones; sulfamides react analogously.
Bailey
Chris D
CD
School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK BS8 1TS.
Houlden
Chris E
CE
Bar
Grégory L J
GL
Lloyd-Jones
Guy C
GC
Booker-Milburn
Kevin I
KI
D015394:Molecular Structure; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D011744:Pyrimidinones