DNA methylation markers: a versatile diagnostic tool for routine clinical use.
In recent years, several new options have been introduced for the treatment of various neoplasias. Biomarkers are urgently needed to improve diagnosis and treatment selection. DNA metlhylation biomarkers unite these desirable characteristics because they relate to key aspects of tumor biology and can be measured reliably on routinely available patient specimens. Recent improvements in DNA methylation marker discovery and efforts to transfer these into routine clinical use are summarized in this review.
Lesche
Ralf
R
Epigenomics AG, Kleine Praisidentenstrasse 1, 10178 Berlin, Germany. ralf.lesche@epigenomics.com
Eckhardt
Florian
F
D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D019175:DNA Methylation; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism
D014408:Biomarkers, Tumor