Maternal serum proinflammatory cytokines in preterm labor with intact membranes: neonatal outcome and histological associations.
Our aim was to compare maternal serum concentrations of interleukin(IL)-1alpha IL-1beta, IL-6 and IL-8 in pregnancies complicated by preterm labor (PTL), with the levels in healthy controls at comparable gestational age, and to determine if these assays have any value in the prediction of early-onset neonatal infection or histological chorioamnionitis. The study population consisted of 65 women with new-onset PTL, and 31 healthy controls. Maternal serum concentrations of IL-6 (8.40 versus 3.30 pg/mL; p = 0.002) and IL-1beta (2.20 versus 0.50 pg/mL; p = 0.003) were significantly higher in patients with PTL as compared to healthy pregnant women. The IL-1beta concentration (13.60 versus 1.20 pg/mL; p = 0.02) was significantly higher in the serum of mothers whose babies developed early-onset infections, than in mothers of newborns that were healthy. However, its predictive value, and the value of the other cytokines studied, was poor. In addition, IL-1beta levels (28.79 versus 5.19 pg/mL; p = 0.001) were significantly higher in patients with histological chorionamnionitis, than in those without the condition,. The cut-off value of >or= 14 pg/mL predicted inflammatory changes with a sensitivity of 80%, specificity of 86%, PPV of 80% and NPV of 86%. IL-1beta seems to be of moderate value in the prediction of histological chorioamnionitis.
Torbé
Andrzej
A
Department of Obstetrics, Gynecology and Neonatology of Pomeranian Medical University, 70-111 Szczecin, Powstańców Wielkopolskich 72, Poland. torbea@wp.pl
Czajka
Ryszard
R
Kordek
Agnieszka
A
Rzepka
Rafał
R
Kwiatkowski
Sebastian
S
Rudnicki
Jacek
J
D000328:Adult; D002821:Chorioamnionitis / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D005321:Extraembryonic Membranes; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007752:Obstetric Labor, Premature / Q000097:blood* / Q000628:therapy*; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012680:Sensitivity and Specificity
D016207:Cytokines; D053583:Interleukin-1beta; D015850:Interleukin-6