title: Effects of 2 or 5 consecutive exercise days on adipocyte area and lipid parameters in Wistar rats.
abstract: BACKGROUND
  Exercise has been prescribed in the treatment and control of dyslipidemias and cholesterolemia, however, lipid responses to different training frequencies in hypercholesterolemic men have been inconsistent. We sought to verify if different frequencies of continuous moderate exercise (2 or 5 days/week, swimming) can, after 8 weeks, promote adaptations in adipocyte area and lipid parameters, as well as body weight and relative weight of tissues in normo and hypercholesterolemic adult male rats.
  
  
  METHODS
  Normal cholesterol chow diet or cholesterol-rich diet (1% cholesterol plus 0.25% cholic acid) were freely given during 8 weeks to the rats divided in 6 experimentals groups: sedentary normal cholesterol chow diet (C); sedentary cholesterol-rich diet (H); 5x per week continuous training normal cholesterol chow diet (TC5) and cholesterol-rich diet (TH5); 2x per week continuos traning normal cholesterol chow diet (TC2) and cholesterol-rich diet (TH2).
  
  
  RESULTS
  No changes were observed in lipid profile in normal cholesterol chow diet, but both 2 a 5 days/week exercise improved this profile in cholesterol-rich diet. Body weight gain was lower in exercised rats. Decrease in retroperitoneal and epididymal relative weights as well as reductions in adipocyte areas under all diets types were observed only in 5 days/week, while 2 days/week showed improvements mainly in cholesterol-rich diet rats.
  
  
  CONCLUSIONS
  Our results confirm the importance of exercise protocols to control dyslipidemias and obesity in rats. The effects of 5 days/week exercise were more pronounced compared with those of 2 consecutive days/week training.
authors.affiliation: Federal University of São Paulo-Baixada Santista, Health Science Center, Santos, Brazil. ricoguerra06@yahoo.com.br
authors.forename: Ricardo L F
authors.initials: RL
authors.lastname: Guerra
authors.forename: Wagner L
authors.initials: WL
authors.lastname: Prado
authors.forename: Nádia C
authors.initials: NC
authors.lastname: Cheik
authors.forename: Fabiana P
authors.initials: FP
authors.lastname: Viana
authors.forename: João Paulo
authors.initials: JP
authors.lastname: Botero
authors.forename: Regina C
authors.initials: RC
authors.lastname: Vendramini
authors.forename: Iracilda Z
authors.initials: IZ
authors.lastname: Carlos
authors.forename: Elizeu A
authors.initials: EA
authors.lastname: Rossi
authors.forename: Ana R
authors.initials: AR
authors.lastname: Dâmaso
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D002001:Adipose Tissue, Brown / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D004041:Dietary Fats; D014280:Triglycerides; D002784:Cholesterol