Synthesis and in vitro antiproliferative activity of new 1,3-(oxytetraethylenoxy)-cyclotriphosphazene derivatives.
A new series of 1,3-(oxytetraethylenoxy)-cyclotriphosphazene derivatives containing aziridine or salicylaldehyde (2-hydroxybenzaldehyde) or its Schiff base units after condensation with 2-chloroethylamine and anthraquinone groups as co-substituents has been synthesized. Their cytostatic activity in vitro against the HL-60, A549 and HCV29T cancer cell lines has been studied. Some of the compounds exhibited antiproliferative activity in the range of the international criteria for synthetic agents (4 microg/ml) against the cell lines being tested.
Siwy
Mariola
M
Center of Polymer Chemistry, PAS, 34 M. Curie-Sklodowska Street, 41-800 Zabrze, Poland.
Sek
Danuta
D
Kaczmarczyk
Bozena
B
Wietrzyk
Joanna
J
Nasulewicz
Anna
A
Opolski
Adam
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001388:Aziridines / Q000737:chemistry; D001547:Benzaldehydes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D001388:Aziridines; D001547:Benzaldehydes; D009943:Organophosphorus Compounds; C033132:aziridine