title: Peptide YY, cholecystokinin, insulin and ghrelin response to meal did not change, but mean serum levels of insulin is reduced in children with Prader-Willi syndrome.
abstract: Prader-Willi syndrome (PWS) is a contiguous gene syndrome characterized by uncontrollable eating or hyperphagia. Several studies have confirmed that plasma ghrelin levels are markedly elevated in PWS adults and children. The study of anorexigenic hormones is of interest because of their regulation of appetite by negative signals. To study the pattern and response of the anorexigenic hormones such as cholecystokinin (CCK) and peptide YY (PYY) to a meal in PWS, we measured the plasma CCK, PYY, ghrelin and serum insulin levels in PWS patients (n=4) and in controls (n=4) hourly for a day, and analyzed hormone levels and hormonal responses to meals. Repeated measures of ANOVA of hormone levels demonstrated that only insulin levels decreased (p=0.013) and CCK (p=0.005) and ghrelin (p=0.0007) increased in PWS over 24 hr. However, no significant group x time interactions (ghrelin: p=0.89, CCK: p=0.93, PYY: p=0.68 and insulin: p=0.85) were observed; in addition, there were no differences in an assessment of a three-hour area under the curve after breakfast. These results suggest that the response pattern of hormones to meals in PWS patients parallels that of normal controls. In addition, the decrease of insulin levels over 24 hr, in spite of obesity and elevated ghrelin levels, suggests that the baseline insulin level, not the insulin response to meals, may be abnormal in patients with PWS.
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, Korea.
authors.forename: Kyung Hoon
authors.initials: KH
authors.lastname: Paik
authors.forename: Dong-Kyu
authors.initials: DK
authors.lastname: Jin
authors.forename: Kyung Han
authors.initials: KH
authors.lastname: Lee
authors.forename: Lee
authors.initials: L
authors.lastname: Armstrong
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Yoo Joung
authors.initials: YJ
authors.lastname: Oh
authors.forename: Seonwoo
authors.initials: S
authors.lastname: Kim
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Kwon
authors.forename: Yon Ho
authors.initials: YH
authors.lastname: Choe
mesh_terms: D000293:Adolescent; D019540:Area Under Curve; D001706:Biopsy; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002766:Cholecystokinin / Q000097:blood*; D054439:Ghrelin; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D008297:Male; D009765:Obesity; D036361:Peptide Hormones / Q000097:blood* / Q000378:metabolism; D019894:Peptide YY / Q000097:blood*; D011218:Prader-Willi Syndrome / Q000097:blood*; D013997:Time Factors
chemical_list: D054439:Ghrelin; D007328:Insulin; D036361:Peptide Hormones; D019894:Peptide YY; D002766:Cholecystokinin