title: Altered mechanisms of vasodilation in aged human skin.
abstract: Human skin blood flow increases in response to increased body core and local skin temperature via distinct reflex and local mechanisms requiring functional nitric oxide (NO) for full expression. The mechanisms mediating cutaneous vasodilation are impaired with primary aging, resulting in attenuated vasodilation. This article highlights recent findings of how age-related vascular impairments in NO signaling contribute to attenuated cutaneous vasodilation.
authors.affiliation: Department of Kinesiology, The Pennsylvania State University, Noll Laboratory, University Park, PA 16802, USA. lma191@psu.edu
authors.forename: Lacy A
authors.initials: LA
authors.lastname: Holowatz
authors.forename: Caitlin S
authors.initials: CS
authors.lastname: Thompson-Torgerson
authors.forename: W Larry
authors.initials: WL
authors.lastname: Kenney
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D012867:Skin / Q000098:blood supply*; D014664:Vasodilation / Q000502:physiology*
chemical_list: D009569:Nitric Oxide