title: Pea seedling histaminase as a novel therapeutic approach to anaphylactic and inflammatory disorders. A plant histaminase in allergic asthma and ischemic shock.
abstract: Amine oxidases (AOs) are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper AOs (Cu-AOs) catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine, and histamine. In the present review, the effects of a plant amine oxidase (Cu-AO, histaminase, EC1.4.3.6) purified from pea seedlings in the modulation of IgE-mediated allergic reactions, and in the prevention of cardiac and splachnic postischemic reperfusion damage are reported.
authors.affiliation: Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Masini
authors.forename: Danielle
authors.initials: D
authors.lastname: Bani
authors.forename: Cosimo
authors.initials: C
authors.lastname: Marzocca
authors.forename: Mircea Alexandru
authors.initials: MA
authors.lastname: Mateescu
authors.forename: Pier Francesco
authors.initials: PF
authors.lastname: Mannaioni
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Federico
authors.forename: Bruno
authors.initials: B
authors.lastname: Mondovì
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000627:therapeutic use*; D000707:Anaphylaxis / Q000188:drug therapy*; D001249:Asthma / Q000188:drug therapy*; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D007249:Inflammation / Q000188:drug therapy*; D018532:Pisum sativum / Q000201:enzymology*; D008517:Phytotherapy / Q000379:methods / Q000639:trends; D010936:Plant Extracts / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D012639:Seeds / Q000201:enzymology; D012769:Shock / Q000209:etiology / Q000517:prevention & control
chemical_list: D010936:Plant Extracts; D006631:Amine Oxidase (Copper-Containing)