An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: a collaborative retrospective study.
BACKGROUND
Adenomatoid odontogenic tumour (AOT) is a benign odontogenic jaw lesion. The aim of this study was to update the biological profile of AOT.


METHODS
Cases published in the literature and cases in files of co-authors were included.


RESULTS
550 new cases were retrieved, and of a total of 1082 cases analysed, 87.2% were found in the second and third decades. The M:F ratio was 1:1.9. 70.8% were of the follicular variant (extrafollicular: 26.9%, peripheral: 2.3%). 64.3% occurred in the maxilla. 60% of follicular AOTs were associated with unerupted canines. Nineteen cases of AOT (2.8%, M:F ratio was 1:1.4) were associated with embedded third molars. Twenty-two peripheral AOTs (2.3%, M:F ratio was 1:5.3) were recorded. The relative frequency (RF) of AOT ranged between 0.6% and 38.5%, revealing a considerably wider AOT/RF range than hitherto reported (2.2-7.1%).


CONCLUSIONS
This updated review based on the largest number of AOT cases ever presented, confirms the distinctive, although not pathognomonic clinicopathological profile of the AOT, its worldwide occurrence, and its consistently benign behaviour.
Philipsen
Hans Peter
HP
Edificio El Condór 30, Urb. Guadalmina Alta, San Pedro de Alcántara, Spain.
Reichart
Peter A
PA
Siar
Chong Huat
CH
Ng
Kok Han
KH
Lau
Shin Hin
SH
Zhang
Xiaolin
X
Dhanuthai
Kittipong
K
Swasdison
Somporn
S
Jainkittivong
Aree
A
Meer
Shabnum
S
Jivan
Vibha
V
Altini
Mario
M
Hazarey
Vinay
V
Ogawa
Ikuko
I
Takata
Takashi
T
Taylor
Adalberto Abel Mosqueda
AA
Godoy
Héctor
H
Delgado
Wilson A
WA
Carlos-Bregni
Roman
R
Macias
Juan Fransisco Reyes
JF
Matsuzaka
Kenichi
K
Sato
Daisuke
D
Vargas
Pablo A
PA
Adebayo
Ezekiel Taiwo
ET
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000569:Americas / Q000453:epidemiology; D001208:Asia / Q000453:epidemiology; D002648:Child; D003481:Cuspid / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D007573:Jaw Neoplasms / Q000453:epidemiology*; D008297:Male; D008339:Mandibular Neoplasms / Q000453:epidemiology; D008441:Maxillary Neoplasms / Q000453:epidemiology; D008964:Molar, Third / Q000473:pathology; D009808:Odontogenic Tumors / Q000453:epidemiology*; D012189:Retrospective Studies; D012737:Sex Factors; D014095:Tooth, Impacted / Q000453:epidemiology; D014097:Tooth, Unerupted / Q000453:epidemiology