title: No association between TGFBR1*6A and lung cancer.
abstract: BACKGROUND
  TGFBR1*6A, a functionally polymorphic allele in the transforming growth factor [beta] receptor 1 gene (TGFBR1), has been hypothesized to increase risk of various cancers. However, little has been documented about connection of this variant with lung cancer.
  
  
  METHODS
  In an attempt to explore whether the TGFBR1*6A is associated with lung cancer, we performed genotyping followed by sequencing in 252 patients with lung cancer and 250 healthy controls.
  
  
  RESULTS
  The frequency for the heterozygote 9A/6A is 13.9% in cases compared with 12.4% in controls, and the odds ratio is 1.14 (95% confidence interval: 0.68-1.91), which is not statistically significant (p = 0.62), suggesting that TGFBR1*6A could not be a cancer susceptibility factor for Chinese patients with lung cancer.
  
  
  CONCLUSIONS
  We have no evidence to support the hypothesis that TGFBR1*6A is associated with lung cancer.
authors.affiliation: Laboratory of Medical Genetics, School of Life Sciences, Suzhou University, Suzhou PR China.
authors.forename: Weiming
authors.initials: W
authors.lastname: You
authors.forename: Zeyi
authors.initials: Z
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Zheng
authors.forename: Shi-Ying
authors.initials: SY
authors.lastname: Zheng
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Zhang
mesh_terms: D017677:Age Distribution; D000483:Alleles; D002681:China / Q000453:epidemiology; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017346:Protein Serine-Threonine Kinases / Q000097:blood / Q000235:genetics*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000097:blood / Q000235:genetics*; D017678:Sex Distribution
chemical_list: D004273:DNA, Neoplasm; D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; C000625841:TGFBR1 protein, human