The role of cyclooxygenase-2 in breast cancer: review.
There is a growing body of evidence that COX-2 expression s a fundamental step in breast cancer pathogenesis acting through prostaglandin-dependent and independent mechanisms. Epidemiological studies suggest that NSAIDs confer a moderate degree of benefit against breast cancer. However further work is required to establish how this enzyme system can be best manipulated for therapeutic benefit.
Singh-Ranger
Gurpreet
G
St George's University of London, London, UK.
Salhab
Mohamed
M
Mokbel
Kefah
K
D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans
D051546:Cyclooxygenase 2