title: Developing with BDNF: a moving experience.
abstract: During development, newly born neurons migrate away from their initial birth sites to their final positions in the mature brain. The neurotrophin BDNF has been shown to regulate the migration of granule cells in the cerebellum. The cellular mechanisms that mediate this chemotactic response have not been resolved. In this issue of Neuron, Zhou et al. show that vesicle trafficking is critical for allowing neurons to respond to a gradient of BDNF.
authors.affiliation: Cell Biology Program, Hospital for Sick Children, Toronto, M5G 1L7 ON, Canada. dkaplan@sickkids.ca
authors.forename: David R
authors.initials: DR
authors.lastname: Kaplan
authors.forename: Freda D
authors.initials: FD
authors.lastname: Miller
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development*; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D002633:Chemotaxis / Q000502:physiology; D006801:Humans; D051379:Mice; D020813:Receptor, trkB / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D020813:Receptor, trkB