title: Brain volumes in Guam dementia vs Parkinson dementia complex vs aging Chamorro adults.
abstract: We sought to determine if Chamorro individuals with a family history of Guam dementia (GD) or Parkinson dementia complex (PDC) exhibit presymptomatic brain MRI changes. Sixty-six Chamorro subjects had neurocognitive assessment and volumetric MRI. MRI brain volumes differed between diagnostic groups (GD, PDC, control) and according to family history. Chamorros with a family history of PDC or dementia may have increased brain atrophy, suggesting a hereditary susceptibility to neurodegenerative disorders.
authors.affiliation: Departments of Neurology, Oregon Health and Science University, Portland, OR 97239, USA. kaye@ohsu.edu
authors.forename: J A
authors.initials: JA
authors.lastname: Kaye
authors.forename: M M
authors.initials: MM
authors.lastname: Moore
authors.forename: D
authors.initials: D
authors.lastname: Galasko
authors.forename: U K
authors.initials: UK
authors.lastname: Craig
authors.forename: R
authors.initials: R
authors.lastname: Adonay
authors.forename: L C
authors.initials: LC
authors.lastname: Silbert
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D000690:Amyotrophic Lateral Sclerosis / Q000208:ethnology / Q000473:pathology* / Q000503:physiopathology; D001284:Atrophy / Q000208:ethnology / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology*; D015331:Cohort Studies; D003704:Dementia / Q000208:ethnology / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006141:Guam / Q000208:ethnology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000208:ethnology / Q000473:pathology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis