[Dermatological side effects of epidermal growth factor receptor inhibitors].
Epidermal growth cell receptors (EGFR) play a key role in tumor proliferation. Their inhibitors (anti-EGFR) are promising treatments for various types of cancers. Papulopustular follicular eruptions are the most frequent dermatological side effect and occur in 45 to 85% of patients receiving this treatment. Paronychias appear after several weeks of treatment. They are painful and impair hand and foot function. A positive correlation seems to exist between the intensity of the papulo-follicular eruption, tumor regression and survival.
Doebelin
Bénédicte
B
Service de dermatologie, Hôpital Edouard Herriot, Lyon (69).
Ly
Arnaud
A
Allombert
Carole
C
Faure
Michel
M
Claudy
Alain
A
D003875:Drug Eruptions / Q000209:etiology*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D006801:Humans
D066246:ErbB Receptors