A common genetic risk factor for colorectal and prostate cancer.
Variants on chromosome 8q24 contribute risk for prostate cancer; here, we tested whether they also modulate risk for colorectal cancer. We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22; P = 4.4 x 10(-6)) and that the apportionment of risk among the variants differs significantly between the two cancers. Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type.
Haiman
Christopher A
CA
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA. haiman@usc.edu
Le Marchand
Loïc
L
Yamamato
Jennifer
J
Stram
Daniel O
DO
Sheng
Xin
X
Kolonel
Laurence N
LN
Wu
Anna H
AH
Reich
David
D
Henderson
Brian E
BE
D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*