title: Outcomes and prognostic factors in patients with head and neck cancer and severe acute illnesses.
abstract: OBJECTIVE
  To evaluate the outcomes of patients with head and neck cancer and severe acute illnesses, and to identify characteristics associated with hospital mortality.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  Ten-bed medical-surgical oncologic intensive care unit (ICU).
  
  
  METHODS
  Consecutive patients admitted to the ICU over a 68-month period.
  
  
  METHODS
  None.
  
  
  RESULTS
  Demographic, clinical and cancer-related data were collected. Multivariate logistic regression analysis was performed to identify predictive factors of hospital mortality. One hundred and twenty-one patients aged 63.3+/-14.7 years were enrolled in the study. The main sites of primary tumor were oral cavity (30%), larynx (25%), pharynx (14%) and thyroid (9%). The main reasons for ICU admission were sepsis (37%) and acute respiratory failure (20%). The mean SAPS II score was 49.6+/-17.8 points, and during ICU stay 100 (83%) patients received mechanical ventilation, 70 (58%), vasopressors, and 12 (10%), dialysis. The ICU, hospital and 6-month mortality rates were 39%, 56% and 72%, respectively. A performance status >or=2 [odds ratio (OR)=5.17 (95% confidence interval, CI=1.84-14.53)], advanced cancer (TNM stage IV) [OR=3.80 (95% CI=1.28-11.28)], and the number of organ failures [OR=2.87 (95% CI=1.83-4.50)] were associated with increased mortality in multivariate analysis.
  
  
  CONCLUSIONS
  In conjunction with clinical judgment and taking into consideration the patient's preferences and values, the knowledge of these outcome predictors may be useful in helping physicians to identify patients who might benefit from the intensive care and to improve discussions on patients' prognosis.
authors.affiliation: Intensive Care Unit, Centro de Tratamento Intensivo, Instituto Nacional de Câncer-INCA, Praça Cruz Vermelha, 23 - 10 Andar, 20230-130, Rio de Janeiro, Brazil. marciosoaresms@yahoo.com.br
authors.forename: Márcio
authors.initials: M
authors.lastname: Soares
authors.forename: Jorge I F
authors.initials: JI
authors.lastname: Salluh
authors.forename: Luisa
authors.initials: L
authors.lastname: Toscano
authors.forename: Fernando L
authors.initials: FL
authors.lastname: Dias
mesh_terms: D000208:Acute Disease; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006258:Head and Neck Neoplasms / Q000145:classification / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome; D018805:Sepsis; D012720:Severity of Illness Index