title: Effect of first myocardial ischemic event on renal function.
abstract: Effects of cardiovascular dysfunction on renal function have been poorly characterized. Therefore, we investigated the relation between a first ischemic cardiac event and long-term renal function changes in the general population from the PREVEND study. We studied 6,360 subjects with a total follow-up duration of 27.017 subject-years. The estimated mean proportional increase in serum creatinine after a first ischemic cardiac event was 3.1% compared with 0.4% per year of follow-up in subjects without such an event (p = 0.005). This represented a significantly larger decrease in estimated glomerular filtration rate after the event in subjects with an event versus the decrease in subjects without a first ischemic cardiac event (2.2 vs 0.5 ml/min/1.73 m(2)/year of follow-up, p = 0.006). In multivariate analysis with adjustment for renal risk factors, this event showed an independent association with serum creatinine change. In conclusion, a first ischemic cardiac event appears to enhance the natural decrease in renal function. Because even mild renal dysfunction should be considered a major cardiovascular risk factor after myocardial infarction, increased renal function loss after an ischemic cardiac event could add to the risk for subsequent cardiovascular morbidity, thus closing a vicious circle.
authors.affiliation: Department of Clinical Pharmacology, Division of Nephrology, University Medical Center Groningen, Groningen, The Netherlands. eijkelkamp@cs.com
authors.forename: Wouter B A
authors.initials: WB
authors.lastname: Eijkelkamp
authors.forename: Pieter A
authors.initials: PA
authors.lastname: de Graeff
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: van Veldhuisen
authors.forename: Richard P E
authors.initials: RP
authors.lastname: van Dokkum
authors.forename: Ronald T
authors.initials: RT
authors.lastname: Gansevoort
authors.forename: Paul E
authors.initials: PE
authors.lastname: de Jong
authors.forename: Dick
authors.initials: D
authors.lastname: de Zeeuw
authors.forename: Hans L
authors.initials: HL
authors.lastname: Hillege
mesh_terms: D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications*; D051437:Renal Insufficiency / Q000097:blood / Q000209:etiology*; D012307:Risk Factors
chemical_list: D003404:Creatinine