Modern prognostic factors and angiogenesis in chronic lymphocytic leukemia: more data needed.
Angiogenesis appears to be an important player in biology of chronic lymphocytic leukemia (CLL). We present here data on association of ZAP-70 expression measured by flow cytometry and plasma levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in 27 untreated CLL patients. We found significantly higher VEGF (but not bFGF) in ZAP-negative patients. Likewise, there was a negative correlation between percentage of ZAP-70 expression and VEGF. Larger, prospective studies are needed to confirm our pilot data.
Smolej
Lukas
L
2nd Department of Internal Medicine, Department of Clinical Hematology, University Hospital and Medical School, Hradec Kralove, Czech Republic. smolej@seznam.cz
Andrys
Ctirad
C
Vroblova
Vladimira
V
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000097:blood; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D010865:Pilot Projects; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000097:blood; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000032:analysis
D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D051746:ZAP-70 Protein-Tyrosine Kinase; C497261:ZAP70 protein, human