title: [Absolute risk for fracture and WHO guideline. Bone turnover markers as predictive factors for osteoporotic fractures].
abstract: Recently, various proteins and enzymes have been used as bone turnover markers to diagnose osteoporosis and diseases of bone metabolism, as well as indices of therapeutic alternatives. In addition to these important clinical roles, there is evidence that bone metabolic markers can be used to identify patients at risk of osteoporotic fractures. The EPIDOS (epidemiologie de l'osteoporose) and OEFLY (os des femmesde lyon) studies found a significant relationship between the values of bone resorption markers and the risk of osteoporotic fractures. We did a population-based cohort study in a mountainous area of Japan and found that bone resorption markers, especially deoxypyridinoline (DPD) , were useful in predicting the risk of vertebral fractures. However, further epidemiological research is needed to facilitate the development of affordable strategies using bone turnover markers for the early identification of high-risk individuals.
authors.affiliation: The University of Tokyo Hospital, 22nd Medical and Research Center, Department of Joint Disease Research.
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D005260:Female; D050723:Fractures, Bone / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000150:complications / Q000175:diagnosis*; D011237:Predictive Value of Tests; D018570:Risk Assessment / Q000379:methods*
chemical_list: D000596:Amino Acids; D015415:Biomarkers; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase