title: Novel gold(I) 7-azacoumarin complex: synthesis, structure, optical properties, and cytotoxic effects.
abstract: A mixture of pyridoxalrhodanine, triethylphosphinegold(I) chloride, and sodium methoxide in methanol unexpectedly afforded the azacoumarin complex [Au(TS)(PEt3)] [HTS = 5-(hydroxymethyl)-8-methyl-3-thiol-7-azacoumarin], which was characterized by X-ray diffractometry. Its crystals consist of independent molecules in which the metal atom is bound to the azacoumarin [Au-S = 2.9458(18) A] and the phosphine [Au-P = 2.262(2) A] in an almost linear arrangement [P1-Au1-S1 = 176.93(7) degrees]. The complex showed better in vitro antitumor activity than cisplatin against the cisplatin-resistant cell line A2780cis.
authors.affiliation: Departamento de Química InorgAnica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Galicia), Spain. qiscasas@usc.es
authors.forename: José S
authors.initials: JS
authors.lastname: Casas
authors.forename: Eduardo E
authors.initials: EE
authors.lastname: Castellano
authors.forename: María D
authors.initials: MD
authors.lastname: Couce
authors.forename: Olga
authors.initials: O
authors.lastname: Crespo
authors.forename: Javier
authors.initials: J
authors.lastname: Ellena
authors.forename: Antonio
authors.initials: A
authors.lastname: Laguna
authors.forename: Agustín
authors.initials: A
authors.lastname: Sanchez
authors.forename: José
authors.initials: J
authors.lastname: Sordo
authors.forename: Carmen
authors.initials: C
authors.lastname: Taboada
mesh_terms: D015392:Chemistry, Inorganic / Q000379:methods; D003374:Coumarins / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008024:Ligands; D000432:Methanol / Q000737:chemistry; D008956:Models, Chemical; D008968:Molecular Conformation; D050607:Organogold Compounds / Q000737:chemistry*; D013696:Temperature; D013816:Thermodynamics
chemical_list: C523501:Au(TS)(PEt3); D003374:Coumarins; D008024:Ligands; D050607:Organogold Compounds; D006046:Gold; C030123:coumarin; D000432:Methanol