title: Staphylococcus aureus pericardial abscess in a child with beta-thalassemia major following double-unit unrelated cord blood transplantation.
abstract: The authors describe a 10-year-old boy with beta-thalassemia major who received double-unit unrelated cord blood transplantation and had a rocky post-transplantation course that included an episode of massive pericardial effusion. Pericardial tube drainage was performed for evacuating fluid. Results showed hemorrhagic pericardial effusion. A Staphylococcus aureus pericardial abscess eventually developed despite antibiotics coverage. Temporary drain placement was unsuccessful and the patient underwent radical pericardiectomy. Although cyclosporine therapy had to be stopped before the 6-month withdrawal, the patient did well with full donor chimerism 14 months post-transplant.
authors.affiliation: Division of Cardiology, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Hung-Tao
authors.initials: HT
authors.lastname: Chung
authors.forename: Ting-Chang
authors.initials: TC
authors.lastname: Hsieh
authors.forename: Mei-Ching
authors.initials: MC
authors.lastname: Yu
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Chang
authors.forename: Wan-Chak
authors.initials: WC
authors.lastname: Lo
authors.forename: Tang-Her
authors.initials: TH
authors.lastname: Jaing
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010490:Pericardial Effusion / Q000209:etiology / Q000382:microbiology* / Q000601:surgery; D010492:Pericardiectomy; D013211:Staphylococcus aureus; D018183:Transplantation Chimera; D017086:beta-Thalassemia / Q000150:complications* / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents