title: Does HPV-status 6-12 months after treatment of high grade dysplasia in the uterine cervix predict long term recurrence?
abstract: BACKGROUND
  Women once treated for high grade cervical dysplasia have a high long term risk for developing new dysplasia or cancer.
  
  
  OBJECTIVE
  To investigate if human papilloma virus (HPV)-negativity after treatment of cervical dysplasia reduces the need for frequent long term follow up.
  
  
  METHODS
  Case/control study based on archival smears.
  
  
  METHODS
  Women with cervical intraepithelial neoplasi (CIN)2-3, treated for dysplasia and with recurrence of CIN2+ more than 2 years after treatment were compared with controls without recurrence, matched for age and date of treatment. High risk-HPV-DNA were analysed with PCR from two archival smears per woman. Mean follow up time was 14.6 years.
  
  
  RESULTS
  24% (45/189) of cases and 11% (43/378) of controls were HPV-positive in any of two smears. Odds ratio (OR)=2.5 (1.6-3.8).
  
  
  CONCLUSIONS
  HPV-status 6-12 months after treatment of high grade dysplasia is of limited value for the design of long term follow up.
authors.affiliation: Department of Obstetrics & Gynaecology, Sahlgrenska Academy, University of Göteborg, SE-413 45 Göteborg, Sweden. bjorn.strander@oc.gu.se
authors.forename: Björn
authors.initials: B
authors.lastname: Strander
authors.forename: Walter
authors.initials: W
authors.lastname: Ryd
authors.forename: Keng-Ling
authors.initials: KL
authors.lastname: Wallin
authors.forename: Bengt
authors.initials: B
authors.lastname: Wärleby
authors.forename: Biying
authors.initials: B
authors.lastname: Zheng
authors.forename: Ian
authors.initials: I
authors.lastname: Milsom
authors.forename: Baback
authors.initials: B
authors.lastname: Gharizadeh
authors.forename: Nader
authors.initials: N
authors.lastname: Pourmand
authors.forename: Agneta
authors.initials: A
authors.lastname: Andersson-Ellström
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000821:virology*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D052163:Human papillomavirus 6 / Q000302:isolation & purification*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000821:virology; D014412:Tumor Virus Infections / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000628:therapy / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D014626:Vaginal Smears