title: TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response.
abstract: TC1 (C8orf4) is associated with aggressive behavior and poor survival in cancer. We have recently reported that it is a target gene of NF-kappaB and regulates the Wnt/beta-catenin pathway. Here, we show that TC1 is upregulated by various cellular stresses and mediates heat shock response. Heat shock and other cellular stresses including H2O2, 12-O-tetradecanoylphorbol 13-acetate (TPA), lipopolysaccharide (LPS), and UV enhance TC1 transcription in HeLa, KATO-III, HEK293T, and HK cells. TC1 protein then moves into the nuclei independently of NF-kappaB activation. TC1 upregulates heat shock proteins, and TC1-knockdown inhibits stress-induced downstream regulation significantly. Heat shock factor 1(HSF1) and TC1 upregulate each other, suggesting a potential positive feedback in the heat shock response regulation. Our data suggest that TC1 is a novel heat shock response regulator.
authors.affiliation: Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
authors.forename: Juhee
authors.initials: J
authors.lastname: Park
authors.forename: Yusun
authors.initials: Y
authors.lastname: Jung
authors.forename: Jungtae
authors.initials: J
authors.lastname: Kim
authors.forename: Ka-Young
authors.initials: KY
authors.lastname: Kim
authors.forename: Sang-Gun
authors.initials: SG
authors.lastname: Ahn
authors.forename: Kyuyoung
authors.initials: K
authors.lastname: Song
authors.forename: Inchul
authors.initials: I
authors.lastname: Lee
mesh_terms: D006367:HeLa Cells; D018869:Heat-Shock Response / Q000502:physiology*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D015854:Up-Regulation / Q000502:physiology
chemical_list: D009363:Neoplasm Proteins; C418741:TCIM protein, human