title: Cyclosporiasis: an emerging public health concern around the world and in Africa.
abstract: BACKGROUND
  Cyclosporiasis is an emerging gastro-enteric disease caused by the coccidia protozoan Cyclospora cayetanensis. It is associated with diarrhoea among children in developing countries, in the Americas where C. cayetanensis is endemic, traveller's diarrhoea and/or food and waterborne outbreaks in the developed countries.
  
  
  OBJECTIVE
  The aim of this review is to highlight cyclosporiasis and its relevance to public health in East Africa and Africa at large.
  
  
  METHODS
  All literature on Cyclospora, C. cayetanensis, cyclosporiasis in Africa, and endemic cyclosporiasis was searched from libraries, colleagues and internet but only literature on its history, clinical presentation, epidemiology in endemic settings, and occurrence in Africa were scrutinised.
  
  
  RESULTS
  In Sub Saharan Africa, cyclosporiasis has been reported in at least 3 countries, including Tanzania, in East Africa, occurring in both immunocompromised and immunocompetent patients. Zoonotic species of Cyclospora have also been identified in East African primates, indicating likely endemicity of this little reported disease in the region. This can be attributed to lack of awareness in the public and medical profession concerning the disease, and therefore not routinely checked at the health centres. Cyclosporiasis is characterized by intermittent diarrhoea, and secondary conditions or sequelae such as reactive arthritis syndrome (Reiter's syndrome), have been associated with progression of the disease. Its management is based on antibiotics, an unusual scenario for a protozoa.
  
  
  CONCLUSIONS
  Although many aspects of this disease and its transmission remain an enigma, the situation has been rapidly changing since the disease first came to medical attention in the 1970s.
authors.affiliation: Centre for Biotechnology Research & Development (CBRD), Kenya Medical Research Institute, P.O. Box 54840 City Square, Nairobi, Kenya. RKaranja@kemri.org
authors.forename: Robert M
authors.initials: RM
authors.lastname: Karanja
authors.forename: Wangeci
authors.initials: W
authors.lastname: Gatei
authors.forename: Njeri
authors.initials: N
authors.lastname: Wamae
mesh_terms: D000349:Africa / Q000453:epidemiology; D000818:Animals; D021744:Cyclospora; D021866:Cyclosporiasis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D011634:Public Health