title: The role of HPV DNA in the evaluation and follow-up of asymptomatic male sexual partners of females with CIN3.
abstract: OBJECTIVE
  To determine whether and how asymptomatic sexual partners of females with high-grade cervical intraepithelial neoplasia (CIN3) lesions should be examined.
  
  
  METHODS
  Sexual partners of females with CIN3 were evaluated for HPV-related lesions by scraping samples for high-risk HPV DNA and androscopy (colposcopic inspection of the penis, scrotum and peri-anal area). Abnormal androscopically detected lesions were sampled for cytology by Pap smears.
  
  
  RESULTS
  74 partners of 87 females were studied and underwent androscopy, and 17 (22.9%) had abnormal findings: 11/74 had clinical genital condyloma acuminata and 6/74 had aceto-white lesions on the penile shaft or scrotum. Cytology of the 17 abnormal androscopies showed that six smears were normal and 11 had atypia and koilocytosis. Positive high-risk HPV DNA indicated that 13/74 (17.5 %) were infected with HPV. Two partners (2/74, 2.8%) had concomitant HPV DNA 16.
  
  
  CONCLUSIONS
  Male sexual partners of females with CIN3 should undergo androscopy and cytology of colposcopically detected abnormal areas.
authors.affiliation: Cervical Pathology Unit, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel-Aviv Sourasky Medical Center Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Bar-Am
authors.forename: J
authors.initials: J
authors.lastname: Niv
mesh_terms: D000293:Adolescent; D000328:Adult; D003127:Colposcopy; D015344:DNA Probes, HPV / Q000032:analysis*; D018562:Disease Transmission, Infectious / Q000517:prevention & control; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000635:transmission*; D010409:Penile Diseases / Q000175:diagnosis*; D010413:Penis / Q000473:pathology / Q000821:virology; D018570:Risk Assessment / Q000379:methods; D012747:Sexual Partners; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis*
chemical_list: D015344:DNA Probes, HPV