title: Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease.
abstract: Recently, a region encompassing the promoter and intron 1 of the paraoxonase 1 gene (PON1) have been associated with the risk of developing Alzheimer's disease (AD) in a large pan-ethnic (Caucasian and African-American) dataset. We attempted to replicate this observation in a large French study of sporadic cases and controls. We confirmed that the proximal promoter and 5' sequence of the PON1 gene may harbor unknown functional variant(s) associated with the risk of developing AD.
authors.affiliation: INSERM U744, Institut Pasteur de Lille, Université de Lille 2, Lille, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Chapuis
authors.forename: Maud
authors.initials: M
authors.lastname: Boscher
authors.forename: Faiza
authors.initials: F
authors.lastname: Bensemain
authors.forename: Dominique
authors.initials: D
authors.lastname: Cottel
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Lambert
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005260:Female; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human