A prospective multicentre survey on the treatment of acute pancreatitis in Italy.
BACKGROUND
The Italian Association for the Study of the Pancreas released a diagnostic and therapeutic algorithm for acute pancreatitis in 1999.


OBJECTIVE
This study focused on the analysis of the therapeutic approach for the treatment of acute pancreatitis in Italy.


METHODS
One thousand, one hundred and seventy-three patients were recruited: 1006 patients (85.8%) had mild acute pancreatitis (MAP) and 167 (14.2%) had the severe acute pancreatitis (SAP); 161 patients showed pancreatic necrosis at computed tomography; 121 patients (10.3%) had sequelae and 36 (3.1%) died.


RESULTS
Non-steroidal anti-inflammatory drugs and tramadol were used more frequently in patients with the MAP whereas opioids and the association schedules were used more frequently in patients with the SAP (P<0.001). Gabexate mesilate was utilised in 831 out of 1173 patients (70.8%); in particular, gabexate mesilate was used in 70.6% patients with MAP and in 73.1% of those with SAP (P=0.521). The duration of the drug administration was significantly shorter in those having MAP than in those having the SAP (P<0.001). The antibiotics most frequently used for the prophylaxis against infection from pancreatic necrosis (43.1%) were carbapenems. Only a small number of patients received enteral nutrition (4.7%). Endoscopic retrograde cholangiopancreatography was carried out in 344 of the 1173 patients (29.3%). Surgery was performed in 48 with SAP (19 had elective biliary surgery and 29 had pancreatic surgery).


CONCLUSIONS
The results of this survey indicate a lack of compliance with the guidelines which regard the indications mainly for interventional endoscopy and surgery.
Pezzilli
R
R
Department of Internal Medicine and Gastroenterology, S. Orsola-Malpighi Hospital, Bologna, Italy. raffaele.pezzilli@aosp.bo.it
Uomo
G
G
Gabbrielli
A
A
Zerbi
A
A
Frulloni
L
L
De Rai
P
P
Castoldi
L
L
Cavallini
G
G
Di Carlo
V
V
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D013505:Digestive System Surgical Procedures / Q000706:statistics & numerical data; D005260:Female; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000188:drug therapy* / Q000453:epidemiology / Q000601:surgery*; D011446:Prospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000700:Analgesics; D000900:Anti-Bacterial Agents; D006633:Histamine Antagonists