title: The treatment of bisphosphonate-associated osteonecrosis of the jaws with bone resection and autologous platelet-derived growth factors.
abstract: BACKGROUND
  Bisphosphonates administered intravenously are used to treat patients with cancer who have hypercalcemia associated with malignant disease, multiple myeloma or metastatic tumors (breast, lung, prostate) in the bones. Bisphosphonates are bone resorption inhibitors and have been associated with osteonecrosis of the jaws. In this article, the authors provide an alternative treatment modality for refractory bisphosphonate-associated osteonecrosis (BON).
  
  
  METHODS
  The authors treated 12 patients with refractory BON and a history of long-term bisphosphonate therapy. Each patient had mucosal ulceration with exposed necrotic bone. The treatment combined bone resection with platelet-derived growth factors (PDGFs). The surgical intervention they used was a marginal resection limited to the alveolar bone. Ten of the patients recovered with complete mucosal and bone healing.
  
  
  CONCLUSIONS
  BON has been shown to be refractory to antibiotics, minor local débridement and 0.12 percent chlorhexidine oral rinse. Treatment of refractory BON with a combination of marginal resection and PDGF has shown favorable results, including complete wound healing in most patients. This modality has been shown to be effective in treating BON and may be a useful alternative to existing treatment strategies.
authors.affiliation: Faxton-St. Luke's Healthcare Dental Service, New Hartford, NY, USA. madornato@aol.com
authors.forename: Michael C
authors.initials: MC
authors.lastname: Adornato
authors.forename: Iyad
authors.initials: I
authors.lastname: Morcos
authors.forename: James
authors.initials: J
authors.lastname: Rozanski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D019647:Oral Surgical Procedures / Q000379:methods*; D010020:Osteonecrosis / Q000139:chemically induced / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D053657:Platelet-Rich Plasma
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D008567:Membranes, Artificial; D010982:Platelet-Derived Growth Factor