Etanercept-related extensive pulmonary nodulosis in a patient with rheumatoid arthritis.
Although nodulosis is a common extraarticular manifestation of rheumatoid arthritis, accelerated pulmonary nodulosis is a rare event. The etiology of rheumatoid nodules is still unknown. Nodulosis is not necessarily associated with active joint inflammation, suggesting different pathogenic mechanisms for nodule formation and synovial tissue inflammation. We describe a patient with extensive pulmonary nodulosis, probably related to etanercept treatment. Our case emphasizes the need for careful monitoring for adverse events during treatment with biologicals, especially since the differential diagnosis often includes a broad spectrum of diseases.
van Ede
Annelies
A
Department of Rheumatology, University Medical Centre Nijmegen, Nijmegen, The Netherlands.
den Broeder
Alfons
A
Wagenaar
Michiel
M
van Riel
Piet
P
Creemers
Marjonne C W
MC
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid; D001379:Azathioprine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D000068800:Etanercept; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011241:Prednisone; D013902:Radiography, Thoracic; D018124:Receptors, Tumor Necrosis Factor; D012218:Rheumatoid Nodule / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D014057:Tomography, X-Ray Computed; D028761:Withholding Treatment
D000893:Anti-Inflammatory Agents; D018501:Antirheumatic Agents; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D018124:Receptors, Tumor Necrosis Factor; D001379:Azathioprine; D000068800:Etanercept; D011241:Prednisone