title: Serum anti-amyloid-beta antibodies and Alzheimer's disease in elderly Korean patients.
abstract: Alzheimer's disease (AD) is characterized by the deposition of senile plaques and neurofibrillary tangles in the brain. The presence of the amyloid-beta (Abeta) peptide in senile plaques seems to play a central role in the neuropathology of AD. Diagnosis of AD involves neuropsychological examinations or magnetic resonance imaging and, to date, a specific diagnostic marker indicating AD has not been found. This study analysed anti-Abeta antibodies from the serum of 153 patients with AD using an enzyme-linked immunosorbent assay method. The levels of anti-Abeta antibody from patients in the control group (n=193) were compared with those of patients with AD. Our results showed a significantly lower anti-Abeta antibody level in patients with AD than in the control group. These results showed that the anti-Abeta antibody level in serum could potentially be used to diagnose the presence of AD.
authors.affiliation: Division of Nursing Science, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: M S
authors.initials: MS
authors.lastname: Song
authors.forename: I
authors.initials: I
authors.lastname: Mook-Jung
authors.forename: H J
authors.initials: HJ
authors.lastname: Lee
authors.forename: J Y
authors.initials: JY
authors.lastname: Min
authors.forename: M H
authors.initials: MH
authors.lastname: Park
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000276:immunology*; D016229:Amyloid beta-Peptides / Q000276:immunology*; D000906:Antibodies / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007723:Korea; D016015:Logistic Models; D008297:Male; D011237:Predictive Value of Tests; D011897:Random Allocation
chemical_list: D016229:Amyloid beta-Peptides; D000906:Antibodies