title: Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer.
abstract: Development of acquired resistance to gefitinib after an initial good response is common. Recently, it was reported that this acquired resistance is related to a secondary mutation associated with a substitution of threonine by methionine at codon 790 (T790M) of the epidermal growth factor receptor (EGFR) gene. In this report, we present a "never smoking" woman with advanced lung cancer who showed acquired resistance to gefitinib, and analysis of autopsy samples revealed no evidence of EGFR mutations in either exons 18-21 or codon 790, and positive immunostaining for breast cancer resistance protein (BCRP). We describe, for the first time, a case in which expression of BCRP was associated with acquired resistance to gefitinib, independent of EGFR mutations.
authors.affiliation: Department of Thoracic Surgery, Tokyo Medical University Hospital, Tokyo 160-0023, Japan. jusuda@tokyo-med.ac.jp
authors.forename: J
authors.initials: J
authors.lastname: Usuda
authors.forename: T
authors.initials: T
authors.lastname: Ohira
authors.forename: Y
authors.initials: Y
authors.lastname: Suga
authors.forename: T
authors.initials: T
authors.lastname: Oikawa
authors.forename: S
authors.initials: S
authors.lastname: Ichinose
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Ohtani
authors.forename: S
authors.initials: S
authors.lastname: Maehara
authors.forename: K
authors.initials: K
authors.lastname: Imai
authors.forename: M
authors.initials: M
authors.lastname: Kubota
authors.forename: Y
authors.initials: Y
authors.lastname: Tsunoda
authors.forename: H
authors.initials: H
authors.lastname: Tsutsui
authors.forename: K
authors.initials: K
authors.lastname: Furukawa
authors.forename: T
authors.initials: T
authors.lastname: Okunaka
authors.forename: Y
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: H
authors.initials: H
authors.lastname: Kato
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001344:Autopsy; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D019008:Drug Resistance, Neoplasm; D017809:Fatal Outcome; D005260:Female; D000077156:Gefitinib; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics*; D011799:Quinazolines / Q000494:pharmacology / Q000627:therapeutic use*; D013902:Radiography, Thoracic; D012907:Smoking; D014057:Tomography, X-Ray Computed
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D011799:Quinazolines; D000077156:Gefitinib