title: Indanylacetic acids as PPAR-delta activator insulin sensitizers.
abstract: A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-alpha and PPAR-delta ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-delta over PPAR-alpha.
authors.affiliation: Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. pcwickens@hotmail.com
authors.forename: Philip
authors.initials: P
authors.lastname: Wickens
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.forename: John
authors.initials: J
authors.lastname: Amatruda
authors.forename: William
authors.initials: W
authors.lastname: Bullock
authors.forename: Michael
authors.initials: M
authors.lastname: Burns
authors.forename: Louis-David
authors.initials: LD
authors.lastname: Cantin
authors.forename: Chih-Yuan
authors.initials: CY
authors.lastname: Chuang
authors.forename: Thomas
authors.initials: T
authors.lastname: Claus
authors.forename: Miao
authors.initials: M
authors.lastname: Dai
authors.forename: Fernando
authors.initials: F
authors.lastname: Dela Cruz
authors.forename: David
authors.initials: D
authors.lastname: Dickson
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: Ehrgott
authors.forename: Dongping
authors.initials: D
authors.lastname: Fan
authors.forename: Sarah
authors.initials: S
authors.lastname: Heald
authors.forename: Martin
authors.initials: M
authors.lastname: Hentemann
authors.forename: Christiana I
authors.initials: CI
authors.lastname: Iwuagwu
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Johnson
authors.forename: Ellalahewage
authors.initials: E
authors.lastname: Kumarasinghe
authors.forename: David
authors.initials: D
authors.lastname: Ladner
authors.forename: Rico
authors.initials: R
authors.lastname: Lavoie
authors.forename: Sidney
authors.initials: S
authors.lastname: Liang
authors.forename: James N
authors.initials: JN
authors.lastname: Livingston
authors.forename: Derek
authors.initials: D
authors.lastname: Lowe
authors.forename: Steve
authors.initials: S
authors.lastname: Magnuson
authors.forename: Gretchen
authors.initials: G
authors.lastname: Mannelly
authors.forename: Ingo
authors.initials: I
authors.lastname: Mugge
authors.forename: Herbert
authors.initials: H
authors.lastname: Ogutu
authors.forename: Susan
authors.initials: S
authors.lastname: Pleasic-Williams
authors.forename: Robert W
authors.initials: RW
authors.lastname: Schoenleber
authors.forename: Jeff
authors.initials: J
authors.lastname: Shapiro
authors.forename: Tatiana
authors.initials: T
authors.lastname: Shelekhin
authors.forename: Laurel
authors.initials: L
authors.lastname: Sweet
authors.forename: Christopher
authors.initials: C
authors.lastname: Town
authors.forename: Manami
authors.initials: M
authors.lastname: Tsutsumi
mesh_terms: D031541:Fluorescence Resonance Energy Transfer; D007333:Insulin Resistance; D047494:PPAR delta / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D047494:PPAR delta