title: Temperature, temperature extremes, and mortality: a study of acclimatisation and effect modification in 50 US cities.
abstract: OBJECTIVE
  The authors examined the increase in mortality associated with hot and cold temperature in different locations, the determinants of the variability in effect estimates, and its implications for adaptation.
  
  
  METHODS
  The authors conducted a case-crossover study in 50 US cities. They used daily mortality and weather data for 6 513 330 deaths occurring during 1989-2000. Exposure was assessed using two approaches. First, the authors determined exposure to extreme temperatures using city-specific indicator variables based on the local temperature distribution. Secondly, they used piecewise linear variables to assess exposure to temperature on a continuous scale above/below a threshold. Effects of hot and cold temperature were examined in season-specific models. In a meta-analysis of the city-specific results, the authors examined several city characteristics as effect modifiers.
  
  
  RESULTS
  Mortality increases associated with both extreme cold (2-day cumulative increase 1.59% (95% CI 0.56 to 2.63)) and extreme heat (5.74% (95% CI 3.38 to 8.15)) were found, the former being especially marked for myocardial infarction and cardiac arrest deaths. The increase in mortality was less marked at less extreme temperatures. The effect of extreme cold (defined as a percentile) was homogeneous across cities with different climates, suggesting that only the unusualness of the cold temperature (and not its absolute value) had a substantial impact on mortality (that is, acclimatisation to cold). Conversely, heat effects were quite heterogeneous, with the largest effects observed in cities with milder summers, less air conditioning and higher population density. Adjustment for ozone led to similar results, but some residual confounding could be present due to other uncontrolled pollutants.
  
  
  CONCLUSIONS
  The authors confirmed in a large sample of cities that both cold and hot temperatures increase mortality risk. These findings suggest that increases in heat-related mortality due to global warming are unlikely to be compensated for by decreases in cold-related mortality and that population acclimatisation to heat is still incomplete.
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA. mmedinar@hsph.harvard.edu
authors.forename: M
authors.initials: M
authors.lastname: Medina-Ramón
authors.forename: J
authors.initials: J
authors.lastname: Schwartz
mesh_terms: D000064:Acclimatization; D000389:Air Conditioning; D002423:Cause of Death; D003080:Cold Temperature; D018592:Cross-Over Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D057232:Global Warming; D006323:Heart Arrest / Q000401:mortality*; D006358:Hot Temperature; D006801:Humans; D009203:Myocardial Infarction / Q000401:mortality*; D010126:Ozone; D011156:Population Density; D012621:Seasons; D014481:United States / Q000453:epidemiology; D014887:Weather
chemical_list: D010126:Ozone