title: Systemic inflammation and lung function in young adults.
abstract: BACKGROUND
  Impaired lung function is associated with systemic inflammation and is a risk factor for cardiovascular disease in older adults. It is unknown when these associations emerge and to what extent they are mediated by smoking, chronic airways disease, and/or established atherosclerosis. We explored the association between the forced expiratory volume in one second (FEV(1)) and the systemic inflammatory marker C-reactive protein (CRP) in young adults.
  
  
  METHODS
  Associations between spirometric lung function and blood CRP were assessed in a population based birth cohort of approximately 1000 New Zealanders at ages 26 and 32 years. Analyses adjusted for height and sex to account for differences in predicted lung function and excluded pregnant women.
  
  
  RESULTS
  There were significant inverse associations between FEV(1) and CRP at both ages. Similar results were found for the forced vital capacity. These associations were similar in men and women and were independent of smoking, asthma, and body mass index.
  
  
  CONCLUSIONS
  Reduced lung function is associated with systemic inflammation in young adults. This association is not related to smoking, asthma, or obesity. The reasons for the association are unexplained, but the findings indicate that the association between lower lung function and increased inflammation predates the development of either chronic lung disease or clinically significant atherosclerosis. The association between poor lung function and cardiovascular disease may be mediated by an inflammatory mechanism.
authors.affiliation: Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. bob.hancox@otago.ac.nz
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hancox
authors.forename: Richie
authors.initials: R
authors.lastname: Poulton
authors.forename: Justina M
authors.initials: JM
authors.lastname: Greene
authors.forename: Susan
authors.initials: S
authors.lastname: Filsell
authors.forename: Christene R
authors.initials: CR
authors.lastname: McLachlan
authors.forename: Finn
authors.initials: F
authors.lastname: Rasmussen
authors.forename: D Robin
authors.initials: DR
authors.lastname: Taylor
authors.forename: Michael J A
authors.initials: MJ
authors.lastname: Williams
authors.forename: Avis
authors.initials: A
authors.lastname: Williamson
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Sears
mesh_terms: D000328:Adult; D001991:Bronchitis / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D014797:Vital Capacity / Q000502:physiology
chemical_list: D002097:C-Reactive Protein