title: The role of SOAT-1 polymorphisms in cognitive decline and delirium after bypass heart surgery.
abstract: BACKGROUND
  Cognitive decline (CD) and delirium (PD) are commonly observed complications after bypass heart surgery. In this study we aimed to investigate whether certain genetic factors (alleles of the SOAT-1 gene) play a role in their appearance.
  
  
  METHODS
  We examined 137 patients receiving coronary bypass surgery with a neuropsychiatric test battery consisting of the Mini Mental State Examination (MMSE), the Brief Psychiatric Rating Scale (BPRS), the Wechsler's Memory Scale-Revised (WMS-R) on admission and one month after surgery, and the Delirium Rating Scale postoperatively, when indicated, and genotyped them in relation to the SOAT-1 genotypes (AA positive group with augmented protection of the nerve cells against stress and the AA negative group--AC and CC subgroups--with diminished protection against stress).
  
  
  RESULTS
  We noted a significant decline in test results postoperatively and a high frequency of delirium (29.92% of the patients). None of these complications could be associated to the SOAT-1 genotypes.
  
  
  CONCLUSIONS
  Our study confirmed the expected cognitive decline and highly frequent delirium after bypass heart surgery and excluded the possible role of SOAT-1 genotype polymorphisms in their genesis.
authors.affiliation: Anaximandrou 24, 3rd Department of Neurology, Papanikolaou Hospital, Thessaloniki, Greece. gtagarakis@hotmail.com
authors.forename: G  I
authors.initials: G
authors.lastname: Tagarakis
authors.forename: F
authors.initials: F
authors.lastname: Tsolaki-Tagaraki
authors.forename: M
authors.initials: M
authors.lastname: Tsolaki
authors.forename: A
authors.initials: A
authors.lastname: Diegeler
authors.forename: D
authors.initials: D
authors.lastname: Kazis
authors.forename: E
authors.initials: E
authors.lastname: Rouska
authors.forename: A
authors.initials: A
authors.lastname: Papassotiropoulos
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003693:Delirium / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D002785:Sterol O-Acyltransferase / Q000235:genetics*; D014888:Wechsler Scales
chemical_list: D002785:Sterol O-Acyltransferase; C493492:sterol O-acyltransferase 1