Viral dynamics in transplant patients: implications for disease.
Viral infections cause substantial morbidity and mortality in transplant patients. Quantifying viral loads is widely appreciated as a direct means to diagnose and monitor the course of viral infections. Recent studies indicate that the kinetics of viral load changes rather than single viral load measurements better correlate with organ involvement. In this Review, we will summarise the current knowledge regarding the kinetics of viruses relevant to transplantation including cytomegalovirus, Epstein-Barr virus, the herpes viruses 6 and 7, hepatitis C virus, GB virus C, adenovirus, and the emerging human polyomavirus type BK. We discuss the implications of viral kinetics for organ pathology as well as for the evaluation of antiviral interventions in transplant patients.
Funk
Georg A
GA
Transplantation Virology, Institute for Medical Microbiology, University of Basel, Basel, Switzerland.
Gosert
Rainer
R
Hirsch
Hans H
HH
D006801:Humans; D014180:Transplantation; D019562:Viral Load; D014777:Virus Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000821:virology; D014780:Viruses / Q000254:growth & development*