Family history of psychiatric disorders and alcohol and substance misuse in patients with bipolar I disorder, substance use disorder, or both.
Family history data were collected on first-degree relatives of 78 patients with bipolar I disorder (BD) and substance use disorder (SUD), 47 with BD only, and 35 with SUD only. The prevalence of psychiatric disorders was significantly higher in first-degree relatives of patients with BD + SUD (64%) and BD (61%) compared with first-degree relatives of SUD patients (20%). The prevalence of alcohol misuse was significantly higher in first-degree relatives of patients with BD + SUD (23.1%) and SUD alone (28.6%) compared to first-degree relatives of patients with BD (4.3%). Our findings suggest that BD and SUD do not share familial risk factors.
Sbrana
Alfredo
A
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita' di Pisa, Pisa, Italy. alfredosbrana@virgilio.it
Bizzarri
Jacopo V
JV
Rucci
Paola
P
Gonnelli
Chiara
C
Massei
Jacopo G
JG
Ravani
Laura
L
Endicott
Jean
J
Maser
Jack D
JD
Cassano
Giovanni B
GB
D000328:Adult; D000437:Alcoholism / Q000453:epidemiology*; D001714:Bipolar Disorder / Q000453:epidemiology*; D015897:Comorbidity; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000453:epidemiology*