Naphthyl tetronic acids as multi-target inhibitors of bacterial peptidoglycan biosynthesis.
Mansour
Tarek S
TS
Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA. mansout@wyeth.com
Caufield
Craig E
CE
Rasmussen
Beth
B
Chopra
Rajiv
R
Krishnamurthy
Girija
G
Morris
Koi M
KM
Svenson
Kristine
K
Bard
Joel
J
Smeltzer
Claudia
C
Naughton
Shaughnessy
S
Antane
Schuyler
S
Yang
Youjun
Y
Severin
Anatoly
A
Quagliato
Dominick
D
Petersen
Peter J
PJ
Singh
Guy
G
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D010457:Peptidoglycan / Q000096:biosynthesis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005663:Furans; D010457:Peptidoglycan; C003422:tetronic acid