title: Women who experience detrusor overactive at lower bladder volumes report greater bother.
abstract: OBJECTIVE
  To explore the relationship of cystometric volume at the time of first detection of detrusor overactive incontinence (DOI) to condition-specific quality of life (QOL).
  
  
  METHODS
  We reviewed consecutive charts of women diagnosed with pure DOI during urodynamic testing. DOI volume was defined as the cystometric volume at the first detection of DOI. Responses to the Urine Distress Inventory (UDI6) and Incontinence Impact Questionnaire (IIQ7) were recorded. Spearman correlations were used to compare independent groups with respect to continuous variables.
  
  
  RESULTS
  Eighty-nine women were included in this analysis. DOI volume was inversely correlated with UDI6 and IIQ7 scores (Spearman's rho = -0.514, P < 0.001 and Spearman's rho = -0.611, P < 0.001). Maximal cystometric capacity was also inversely correlated with UDI6 and IIQ7 scores (rho = -0.458, P < 0.0001 and Spearman's rho = -0.43, P < 0.0001).
  
  
  CONCLUSIONS
  Women who experience DOI at lower volumes during urodynamics report greater bother and QOL impact from incontinence than women who leak at higher volumes.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA. llowenstein@lumc.edu.
authors.forename: Lior
authors.initials: L
authors.lastname: Lowenstein
authors.forename: Kimberly
authors.initials: K
authors.lastname: Kenton
authors.forename: Yashika
authors.initials: Y
authors.lastname: Dooley
authors.forename: Elizabeth
authors.initials: E
authors.lastname: R Mueller
authors.forename: Linda
authors.initials: L
authors.lastname: Brubaker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D011788:Quality of Life; D012189:Retrospective Studies; D012720:Severity of Illness Index; D001743:Urinary Bladder / Q000473:pathology* / Q000503:physiopathology; D053201:Urinary Bladder, Overactive / Q000503:physiopathology*; D014550:Urinary Incontinence, Stress / Q000503:physiopathology*; D014563:Urodynamics / Q000502:physiology