TNF family ligands define niches for T cell memory.
Immunological memory is a critical feature of the adaptive immune system and the underlying principal behind vaccination. The mechanisms that maintain memory T cell survival between the initial and subsequent encounter with antigen remain incompletely defined. Although the cytokines IL-15 and IL-7 are important in memory T cell homeostasis, additional signals by way of TNFR family members are required for maximal maintenance of T cell memory. Here we propose a unifying model in which subsets of TNF family ligands distinguish the competitive niches for maintenance of CD4 versus CD8 T cell memory. Understanding the unique 'memory niches' defined by TNF family ligand expression will provide new insights into the mechanisms of memory T cell maintenance.
Sabbagh
Laurent
L
Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Snell
Laura M
LM
Watts
Tania H
TH
D053330:4-1BB Ligand / Q000502:physiology; D000818:Animals; D039521:CD11c Antigen / Q000502:physiology; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007156:Immunologic Memory; D017730:Ki-1 Antigen / Q000502:physiology; D053262:Receptors, OX40 / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*; D047990:TNF Receptor-Associated Factor 1 / Q000502:physiology
D053330:4-1BB Ligand; D039521:CD11c Antigen; D016207:Cytokines; D017730:Ki-1 Antigen; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor; D047990:TNF Receptor-Associated Factor 1; C505716:TNFRSF4 protein, human