[Tissue culture inactivated vaccine for the prevention of Japanese encephalitis: experimental and laboratory process and control layout].
A process flow diagram was elaborated for production and control of tissue culture inactivated vaccine (TCIV) against Japanese encephalitis (JE). The vaccine was prepared on the basis of the earlier patented JE virus strain (K3). Experimental laboratory JE TCIV series were obtained; their safety and high immunogenicity were tested on animals. Regulations (an instruction) for preparing and controlling JE TCIV have been worked out, which have been approved by the Academic Council of the D. I. Ivanovsky Institute of Virology.
Loginova
I V
IV
Deriabin
P G
PG
Tikhomirov
E E
EE
Karpova
E F
EF
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D002478:Cells, Cultured; D002642:Chick Embryo; D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D004672:Encephalitis, Japanese / Q000097:blood / Q000276:immunology* / Q000517:prevention & control*; D005557:Formaldehyde; D006168:Guinea Pigs; D006385:Hemagglutination Inhibition Tests; D007114:Immunization; D007115:Immunization Schedule; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D022321:Japanese Encephalitis Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification* / Q000633:toxicity*; D051379:Mice; D009500:Neutralization Tests; D011817:Rabbits
D000914:Antibodies, Viral; D022321:Japanese Encephalitis Vaccines; D005557:Formaldehyde