title: Comparison of total laparoscopic and abdominal radical hysterectomy for patients with early-stage cervical cancer.
abstract: OBJECTIVE
  To compare intraoperative, pathologic, and postoperative outcomes of total laparoscopic radical hysterectomy with abdominal radical hysterectomy and pelvic lymphadenectomy for women with early-stage cervical cancer.
  
  
  METHODS
  We reviewed all patients who underwent total laparoscopic radical hysterectomy or abdominal radical hysterectomy and pelvic lymphadenectomy between 2004 and 2006.
  
  
  RESULTS
  Fifty-four patients underwent abdominal radical hysterectomy, and 35 underwent total laparoscopic radical hysterectomy. Mean age was 41.8 years, and mean body mass index 28.1. There was no difference in demographic or tumor factors between the two groups. Mean estimated blood loss was 548 mL with abdominal radical hysterectomy compared with 319 mL with total laparoscopic radical hysterectomy (P=.009), and 15% of patients who underwent abdominal radical hysterectomy required a blood transfusion compared with 11% who underwent total laparoscopic radical hysterectomy (P=.62). Mean operative time was 307 minutes for abdominal radical hysterectomy compared with 344 minutes for total laparoscopic radical hysterectomy (P=.03). On pathologic examination, there was no significant difference in the amount of parametrial tissue, vaginal cuff, or negative margins obtained. A mean 19 pelvic nodes were obtained during abdominal radical hysterectomy compared with 14 during total laparoscopic radical hysterectomy (P=.001). The median duration of hospital stay was significantly shorter for total laparoscopic radical hysterectomy (2.0 compared with 5.0 days, P<.001). For abdominal radical hysterectomy, 53% of patients experienced postoperative infectious morbidity compared with 18% for total laparoscopic radical hysterectomy (P=.001). There was no difference in postoperative noninfectious morbidity. There was no difference in return of urinary function.
  
  
  CONCLUSIONS
  Total laparoscopic radical hysterectomy reduces operative blood loss, postoperative infectious morbidity, and postoperative length of stay without sacrificing the size of radical hysterectomy specimen margins; however, total laparoscopic radical hysterectomy is associated with increased operative time.
authors.affiliation: Department of Gynecologic Oncology, the University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. mfrumovitz@mdanderson.org
authors.forename: Michael
authors.initials: M
authors.lastname: Frumovitz
authors.forename: Ricardo
authors.initials: R
authors.lastname: dos Reis
authors.forename: Charlotte C
authors.initials: CC
authors.lastname: Sun
authors.forename: Michael R
authors.initials: MR
authors.lastname: Milam
authors.forename: Michael W
authors.initials: MW
authors.lastname: Bevers
authors.forename: Jubilee
authors.initials: J
authors.lastname: Brown
authors.forename: Brian M
authors.initials: BM
authors.lastname: Slomovitz
authors.forename: Pedro T
authors.initials: PT
authors.lastname: Ramirez
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000601:surgery*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D010535:Laparoscopy; D007902:Length of Stay; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000601:surgery*