Chest CT findings in patients with inflammatory myopathy and Jo1 antibodies.
Thoracic high-resolution computed tomography scans (HRCT) of 17 patients with inflammatory muscle disorders (IMD) and positive Jo1 antibodies were retrospectively reviewed regarding presence, extension, and distribution of pathological findings. Abnormal findings were found in 14 (82.3%) patients. The predominant CT abnormality was ground glass attenuation, which was present in seven patients (41.1%), having a bilateral and diffuse distribution. In general, lesions tended to appear in the lower lobes and more specifically in the lung bases. Interlobular septal thickening was found in six patients (35.3%); it was seen in the upper and lower lobes with peripheral distribution and bilateral localization in five out of six patients. Bronchiectases, reticular opacities, and honeycombing were found in six patients (35.3%). Air space consolidation was seen in about 17% of the patients. Lung involvement is a frequent feature of IMD patients with positive Jo1 antibodies and its most common radiological pattern is that of nonspecific interstitial pneumonia.
Karadimitrakis
Stylianos
S
University of Athens Medical School, Department of Pathophysiology, Laiko University Hospital, 75 M. Asias Street, 11527 Athens, Greece.
Plastiras
Sotiris C
SC
Zormpala
Alexandra
A
Chatzikonstantinou
Konstantinos
K
Boki
Kyriaki A
KA
Tzelepis
George E
GE
Moutsopoulos
Haralampos M
HM
D001323:Autoantibodies; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging*; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000150:complications*; D013902:Radiography, Thoracic; D012189:Retrospective Studies; D013577:Syndrome; D014057:Tomography, X-Ray Computed / Q000379:methods*
D001323:Autoantibodies