Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection.
Clinical and virologic manifestations of genital herpes simplex virus type 2 (HSV-2) infection vary widely. We examined frequencies of single-nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) 2, 3, 4, and 9 in a prospective cohort of 128 HSV-2-infected persons whose viral shedding and lesion frequency was measured by daily sampling from genital secretions. Two TLR2 haplotypes (2 and 4) were associated with increased lesional (P=.008 and P=.03) and shedding (P=.02 and P=.001) rates. An SNP in haplotype 2 (-15607A/G) was also associated with shedding (P=.01) and lesional (P=.008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection.
Bochud
Pierre-Yves
PY
Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103, USA. pyb@systemsbiology.org
Magaret
Amalia S
AS
Koelle
David M
DM
Aderem
Alan
A
Wald
Anna
A
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D004279:DNA, Viral / Q000235:genetics; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006558:Herpes Genitalis / Q000235:genetics* / Q000473:pathology / Q000821:virology*; D018258:Herpesvirus 2, Human / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D051195:Toll-Like Receptor 2 / Q000235:genetics*
D004279:DNA, Viral; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2