title: Effects of desflurane on middle ear pressure.
abstract: OBJECTIVE
  To evaluate the effects of desflurane on middle ear pressure.
  
  
  METHODS
  A prospective clinical study.
  
  
  METHODS
  In this study, 38 ears of 19 male children that were scheduled for circumcision were included. Baseline tympanometry reading was performed on each ear just before anesthesia. After induction anesthesia with propofol a laryngeal mask was applied and desflurane administration was started. The next tympanometry reading was taken at 5th, 10th and 15th minute after administration and at the 10th minute after the cessation of desflurane. Data were analysed using Wilcoxon test.
  
  
  RESULTS
  Mean MEP values before anesthesia in 38 ears of 19 boys were -10.32+/-33.14. After starting the administration of desflurane 5th minute mean value was 71.15+/-60.42, at the 10 th minute 111.56+/-59.03 and at the 15th minute it increased to 120.50+/-54.14, and these measurements were significantly higher than the starting value (p<0.001). After cessation of desflurane mean MEP value dropped to 57.56+/-79.06, but compared with the starting value this was also significantly higher (p<0.001).
  
  
  CONCLUSIONS
  Desflurane may increase the middle ear pressure and it may be unsuitable for certain middle ear surgeries.
authors.affiliation: Duzce University, Duzce Medical Faculty, Department of Otorhinolaryngology, P. K. 8, 81010 Duzce, Turkey. ozturko_70@yahoo.com
authors.forename: Ozcan
authors.initials: O
authors.lastname: Ozturk
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Ilce
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Demiraran
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Iskender
authors.forename: Ender
authors.initials: E
authors.lastname: Guclu
authors.forename: Sahnur
authors.initials: S
authors.lastname: Yildizbas
mesh_terms: D000158:Acoustic Impedance Tests; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D002648:Child; D002944:Circumcision, Male; D000077335:Desflurane; D004432:Ear, Middle / Q000187:drug effects*; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D011182:Postoperative Care; D011312:Pressure; D011446:Prospective Studies
chemical_list: D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane