title: [Genomic instability in nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To evaluate the effect of genomic instability on prognostics in nasopharyngeal carcinoma.
  
  
  METHODS
  Genomic instability was assessed by inter-simple sequence repeats polymerase chain reaction (inter-SSR PCR) in 38 patients with nasopharyngeal carcinoma. Characterization and verification of band alterations shared in different tumors were carried out by sequencing and nest PCR.
  
  
  RESULTS
  Thirty-one (81.6%) of the 38 patients showed genomic altercations, and genomic instability index ranged 0 to 16.2 percent. A gain-based genomic damage shared in 6 tumors was identified on chromosome 6q27. Genomic alteration was significantly more in patients less than 5-year survival than those with more than 5-year survival (P<0.05).
  
  
  CONCLUSIONS
  Genomic instability can be an early event marker in carcinogenesis of nasopharyngeal carcinoma. Aggravation of genomic alterations is a poor prognosis for cancer recovery.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: He-qing
authors.initials: HQ
authors.lastname: Li
authors.forename: Yu-min
authors.initials: YM
authors.lastname: Zhu
authors.forename: Jiang-bo
authors.initials: JB
authors.lastname: Chen
authors.forename: Guo-lin
authors.initials: GL
authors.lastname: Tan
mesh_terms: D001483:Base Sequence; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D004252:DNA Mutational Analysis; D042822:Genomic Instability; D006801:Humans; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction / Q000379:methods; D011379:Prognosis; D016019:Survival Analysis