Concomitant EBV-related B-cell proliferation and juvenile myelomonocytic leukemia in a 2-year-old child.
We present a case of a 2-year-old girl, who developed concomitant EBV-related B-cell proliferation and juvenile myelomonocytic leukemia (JMML). JMML was initially not recognized because of predominant B-cell proliferation. The activating N-RAS mutation was retrospectively already detectable at this early stage. Our findings support the hypothesis that EBV may contribute to JMML pathogenesis by stimulating pre-existing malignant clones. However, such stimulation of leukemic clone does not require the direct incorporation of the virus into myeloid progenitors. Most probably a cytokine burst resulting from EBV infection allows expansion of pre-existing malignant myeloid progenitors. Further studies are required to delineate exact mechanisms of EBV-related promotion of the JMML clone.
Janik-Moszant
Anna
A
Department of Pediatric Hematology and Oncology, Silesian Medical Academy, Zabrze, Poland.
Barć-Czarnecka
Małgorzata
M
van der Burg
Mirjam
M
Langerak
Anton W
AW
Hartwig
Nico G
NG
Vossen
Ann C T M
AC
Niemeyer
Charlotte M
CM
Wachowiak
Jacek
J
Sońta-Jakimczyk
Danuta
D
Szczepański
Tomasz
T
D001402:B-Lymphocytes / Q000821:virology*; D049109:Cell Proliferation; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D006801:Humans; D054429:Leukemia, Myelomonocytic, Juvenile / Q000150:complications*; D008218:Lymphocytosis / Q000150:complications* / Q000821:virology*