Spontaneous resolution of acquired factor V inhibitor associated with ovarian carcinoma.
A 74-year-old lady who presented initially with loin pain and haematuria, then melaena was found to have a prothrombin time ratio (PTR) > 10 and activated partial thromboplastin time ratio (APTTR) > 7. A factor V inhibitor was diagnosed. She was managed with supportive care and the FV inhibitor resolved. A few weeks later she developed abdominal swelling and ascites and was found to have an ovarian tumour. This is the first case, as far as we are aware, of a malignancy-associated FV antibody that has spontaneously remitted before overt presentation of the tumour and illustrates the value of adopting an expectant approach to the management of acquired FV inhibitors.
Maughan
E O
EO
Department of Haematology, Worcestershire Acute Hospitals NHS Trust, Charles Hastings Way, Worcester, UK. elizabeth.maughan@worcsacute.wmids.nhs.uk
Wilson
J
J
Wilde
J T
JT
D000368:Aged; D001323:Autoantibodies / Q000097:blood; D005165:Factor V / Q000037:antagonists & inhibitors*; D005260:Female; D006417:Hematuria / Q000097:blood / Q000209:etiology; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood*; D010949:Plasma; D012075:Remission, Spontaneous
D001323:Autoantibodies; D005165:Factor V