Intracellular kinases in semaphorin signaling.
Originally identified as collapse-inducing and repellent proteins for neuronal processes, semaphorins are now implicated in a diverse array of cellular responses, contributing not only to embryonic development, but also to the maintenance of tissue integrity in the adult organism. In addition, semaphorins play a role in the pathological context. Some Semaphorins can act at a distance, facilitating the navigation of cells or axonal process, whilst others evoke responses in a contact-dependent fashion. The intracellular signaling mechanisms employed by the semaphorins are beginning to be determined, and much work in recent years implicates a host of intracellular kinases in mediating Semaphorin function. These include the tyrosine kinase Fyn and the serine/threonine kinases Cdk5, GSK3, MAPK, and LIMK, and the lipid kinase PI3K. What follows is a review of this work with respect to their functions in mediating specific semaphorin-induced responses.
Ahmed
Aminul
A
MRC Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK.
Eickholt
Britta J
BJ
D000818:Animals; D006801:Humans; D007424:Intracellular Fluid / Q000201:enzymology* / Q000378:metabolism; D008958:Models, Molecular; D008959:Models, Neurological; D011494:Protein Kinases / Q000737:chemistry / Q000502:physiology*; D039961:Semaphorins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D039961:Semaphorins; D011494:Protein Kinases