title: Mycophenolic acid as a latent agonist of PPARgamma.
abstract: Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor gamma (PPARgamma).
authors.affiliation: Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Kita-9, Nishi-9, Sapporo, Japan. m-ub@for.agr.hokudai.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Ubukata
authors.forename: Hitomi
authors.initials: H
authors.lastname: Takamori
authors.forename: Misaki
authors.initials: M
authors.lastname: Ohashi
authors.forename: Shinya
authors.initials: S
authors.lastname: Mitsuhashi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yamashita
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Asada
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Nakajima
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Matsuura
authors.forename: Mie
authors.initials: M
authors.lastname: Tsuruga
authors.forename: Keiko
authors.initials: K
authors.lastname: Taki
authors.forename: Junji
authors.initials: J
authors.lastname: Magae
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D008024:Ligands; D051379:Mice; D008956:Models, Chemical; D009173:Mycophenolic Acid / Q000494:pharmacology*; D047495:PPAR gamma / Q000819:agonists* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D008024:Ligands; D047495:PPAR gamma; D009173:Mycophenolic Acid