[Clinical value of the detection of hepatitis C virus core antigen].
OBJECTIVE
To explore the value of detecting hepatitis C virus core antigen in HCV infected diseases.


METHODS
The HCV-RNA was tested by fluorescent quantitative polymerase chain reaction (FQ-PCR). The core antigens of HCV and anti-HCV were tested by enzyme-linked immunosorbent assay (ELISA).


RESULTS
The positive rate of HCV-RNA in 191 patients was 71.2%, about 136 in 191. The positive rate of anti-HCV was 97.4%, about 186 in 191. The positive rate of HCV core antigen was 33.0%, about 63 in 191. After antiviral therapy for 2 patients,their HCV-RNA and anti-HCV were detected negative but their HCV core antigen was detected positive. In another patient, his anti-HCV was negative but his HCV core antigen was positive.


CONCLUSIONS
As a supplemental test for anti-HCV examination the detection of HCV core antigen is of important clinical value in HCV infection diagnosis.
Lu
Ye-cheng
YC
Clinical Laboratory, the 8th People's Hospital of Guangzhou, Guangzhou 510060, China.
Jiang
Zhen-you
ZY
Kuang
Yan-ling
YL
Chen
Wan-shan
WS
Tan
Yi-zhou
YZ
Li
Di-rong
DR
D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000276:immunology; D018936:Hepatitis C Antigens / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012367:RNA, Viral; D055815:Young Adult
D018937:Hepatitis C Antibodies; D018936:Hepatitis C Antigens; D012367:RNA, Viral