title: Common variants in WFS1 confer risk of type 2 diabetes.
abstract: We studied genes involved in pancreatic beta cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.
authors.affiliation: UK Medical Research Council (MRC) Epidemiology Unit, Strangeways Research Laboratory, Cambridge CB1 8RN, UK. manj.sandhu@srl.cam.ac.uk
authors.forename: Manjinder S
authors.initials: MS
authors.lastname: Sandhu
authors.forename: Michael N
authors.initials: MN
authors.lastname: Weedon
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Fawcett
authors.forename: Jon
authors.initials: J
authors.lastname: Wasson
authors.forename: Sally L
authors.initials: SL
authors.lastname: Debenham
authors.forename: Allan
authors.initials: A
authors.lastname: Daly
authors.forename: Hana
authors.initials: H
authors.lastname: Lango
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Frayling
authors.forename: Rosalind J
authors.initials: RJ
authors.lastname: Neumann
authors.forename: Richard
authors.initials: R
authors.lastname: Sherva
authors.forename: Ilana
authors.initials: I
authors.lastname: Blech
authors.forename: Paul D
authors.initials: PD
authors.lastname: Pharoah
authors.forename: Colin N A
authors.initials: CN
authors.lastname: Palmer
authors.forename: Charlotte
authors.initials: C
authors.lastname: Kimber
authors.forename: Roger
authors.initials: R
authors.lastname: Tavendale
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Morris
authors.forename: Mark I
authors.initials: MI
authors.lastname: McCarthy
authors.forename: Mark
authors.initials: M
authors.lastname: Walker
authors.forename: Graham
authors.initials: G
authors.lastname: Hitman
authors.forename: Benjamin
authors.initials: B
authors.lastname: Glaser
authors.forename: M Alan
authors.initials: MA
authors.lastname: Permutt
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Hattersley
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
authors.forename: Inês
authors.initials: I
authors.lastname: Barroso
mesh_terms: D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D008565:Membrane Proteins; C114987:wolframin protein