The intracellular region of Notch ligands: does the tail make the difference?
The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals.
Pintar
Alessandro
A
International Centre for Genetic Engineering and Biotechnology, Protein Structure and Bioinformatics Group, AREA Science Park, Padriciano 99, I-34012 Trieste, Italy. pintar@icgeb.org
De Biasio
Alfredo
A
Popovic
Matija
M
Ivanova
Neli
N
Pongor
Sándor
S