title: Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome.
abstract: Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C-cells which can secrete adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing factor (CRF) in abnormally high concentrations, potentially causing paraneoplastic Cushing's Syndrome (CS). We report on a 42-year-old male patient with a ten year history of metastatic medullary thyroid carcinoma suffering from paraneoplastic Cushing's Syndrome caused by ectopic hypersecretion of ACTH and a simultaneous Cortisol producing adrenal metastasis.
authors.affiliation: Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital, Ruhr-University Bochum, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Sand
authors.affiliation: Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital, Ruhr-University Bochum, Germany.
authors.forename: Samuel
authors.initials: S
authors.lastname: Uecker
authors.affiliation: Department of Dermatology and Allergology, Ruhr-University Bochum, Germany.
authors.forename: Falk G
authors.initials: FG
authors.lastname: Bechara
authors.affiliation: Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital, Ruhr-University Bochum, Germany.
authors.forename: Marcos
authors.initials: M
authors.lastname: Gelos
authors.affiliation: Department of Physiological Science, University of California Los Angeles (UCLA), USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Sand
authors.affiliation: Department of Radiology, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum, Germany.
authors.forename: Till H
authors.initials: TH
authors.lastname: Wiese
authors.affiliation: Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital, Ruhr-University Bochum, Germany.
authors.forename: Benno
authors.initials: B
authors.lastname: Mann