title: Medicinal flowers. XVI. New dammarane-type triterpene tetraglycosides and gastroprotective principles from flower buds of Panax ginseng.
abstract: The oligoglycoside fraction from the flower buds of Panax ginseng C. A. MEYER (Araliaceae) was found to show protective effects on ethanol-induced gastric mucosal lesions in rats. From the oligoglycoside fraction, new dammarane-type triterpene tetraglycosides, floralginsenosides M, N, O, and P, were isolated together with the major oligoglycosides ginsenoside Rd and Re. The structures of the new floralginsenosides were elucidated on the basis of chemical and physicochemical evidence. Ginsenoside Rd (protopanaxadiol 3,20-O-bisdesmoside) exhibited inhibitory effects on ethanol- and indomethacin-induced gastric mucosal lesions in rats.
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan. myoshika@mb.kyoto-phu.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sugimoto
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Hayaka
authors.initials: H
authors.lastname: Sakumae
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D000431:Ethanol; D035264:Flowers / Q000737:chemistry*; D005765:Gastrointestinal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D007213:Indomethacin; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification; D000097669:Dammaranes
chemical_list: D000431:Ethanol; D005765:Gastrointestinal Agents; D006027:Glycosides; D007213:Indomethacin; D014315:Triterpenes; D000097669:Dammaranes