A novel HLA-G allele (HLA-G*0108) with an alpha-3 domain amino acid change.
HLA-G non classical class I locus shows a comparatively low polymorphism. It encodes for tolerogenic HLA molecules that may be important in autoimmunity and transplant (and foetal) rejection control. HLA-G molecules give negative signals to Natural Killer and T lymphocytes. In the present paper, a new allele, HLA-G*08, is described, which may be useful for monitoring transplants and for HLA and disease studies.
Moscoso
J
J
Department of Immunology, Universidad Complutense, Madrid Regional Blood Center, Madrid, Spain.
Serrano-Vela
J I
JI
Perez-Saborido
B
B
Moreno
E
E
Arnaiz-Villena
A
A
D019943:Amino Acid Substitution / Q000235:genetics*; D006680:HLA Antigens / Q000737:chemistry / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D017434:Protein Structure, Tertiary / Q000235:genetics
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I