title: Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population.
abstract: The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene. FHIT performed a crucial function in the tumorigenesis of lung cancer. The inactivation of FHIT via genetic alterations, including the chromosomal deletions and aberrant transcription, are often associated with lung cancer. In this study, the association between FHIT and lung cancer development was evaluated in a study of Korean patients. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed. Logistic regression analyses were conducted in order to characterize the association between FHIT polymorphisms and lung cancer risk. Via direct sequencing in 24 Korean individuals, 27 sequence variants were identified. Eleven of these polymorphisms were selected for a larger scale genotyping (n = 595). Our finding indicated that the polymorphisms and haplotypes in the FHIT gene are not associated with lung cancer in the Korean population.
authors.affiliation: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
authors.forename: Hae-Yun
authors.initials: HY
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
authors.forename: Jae Sook
authors.initials: JS
authors.lastname: Sung
authors.affiliation: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Whang
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, 371-28 Gasan-Dong, Geumcheon-Gu, Seoul, Korea.
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, 371-28 Gasan-Dong, Geumcheon-Gu, Seoul, Korea.
authors.forename: Byung Lae
authors.initials: BL
authors.lastname: Park
authors.affiliation: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
authors.forename: Jun Suk
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Shin
authors.affiliation: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
authors.forename: Hee Yun
authors.initials: HY
authors.lastname: Seo
authors.affiliation: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
authors.forename: Hwa Jung
authors.initials: HJ
authors.lastname: Sung
authors.affiliation: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
authors.forename: In Keun
authors.initials: IK
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
authors.forename: Sang Cheul
authors.initials: SC
authors.lastname: Oh
authors.affiliation: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Seo
authors.affiliation: Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea. yhk0215@korea.ac.kr.
authors.forename: Yeul Hong
authors.initials: YH
authors.lastname: Kim
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk; D017422:Sequence Analysis, DNA; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase