An elegant synthesis of Zetaclausenamide.
Zetaclausenamide, which was isolated as a hepatoprotective agent from the leaves of medicinal plant Clausena lansium, was synthesized for the first time in six steps including Darzen's condensation, photoisomerization, and the final cyclization reactions.
Ma
Nianchun
N
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. manianch@yahoo.com
Wu
Kemei
K
Huang
Liang
L
D003500:Cyclization; D007769:Lactams / Q000737:chemistry*; D008027:Light; D017705:Lignans / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D027821:Rutaceae / Q000737:chemistry*
D007769:Lactams; D017705:Lignans; C053048:clausenamide