Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms.
The function of many receptors and transport proteins that reside at the surface of the cell is regulated by endocytosis and postendocytic trafficking. Modification of receptors and transporters by ubiquitin conjugation has recently emerged as the major regulatory mechanism of internalization and intracellular sorting of these membrane proteins. This review will describe recent advances in elucidating the mechanisms of ubiquitination of mammalian receptors and transporters using two examples: the receptor for epidermal growth factor and the dopamine transporter. How ubiquitination controls the endocytosis and turnover of these proteins will be also discussed.
Miranda
Manuel
M
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA.
Sorkin
Alexander
A
D000818:Animals; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
D026901:Membrane Transport Proteins; D011956:Receptors, Cell Surface; D025801:Ubiquitin