Protective role of ascorbic acid on subacute sperm toxicity in male New Zealand white rabbits treated with endosulfan.
The ameliorating effect of oral ascorbic acid (AA) was evaluated against changes in sperm parameters in New Zealand White (NZW) rabbits treated with endosulfan. Rabbits (6 to 8 months old) were divided into four groups of six animals each. Rabbits in TRT-I served as control and received corn oil by oral gavage for 6 weeks. Rabbits in TRT-II received endosulfan (1 mg/kg bw per day) in corn oil. TRT-III group received oral corn oil daily and ascorbic acid (AA; 20 mg/kg bw) every other day for 6 weeks. TRT-IV group received the same amounts of endosulfan and AA. Endosulfan alone significantly reduced the sperm count and motility and increased the presence of sperm with morphologic problems. AA treatment showed significant amelioration when coupled with endosulfan. Ameliorations were up to control levels in all cases except for sperm motility. The data suggested that AA has beneficial influences in neutralizing the toxic effects of endosulfan in the spermatologic parameters of NZW males.
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Department of Theriogenology and Artificial Insemination, Mehmet Akif Ersoy University, Burdur, Turkey.
Hatipoglu
F S
FS
Yildiz-Gulay
O
O
Gulay
M S
MS
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D004726:Endosulfan / Q000008:administration & dosage / Q000633:toxicity*; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D011817:Rabbits; D013076:Sperm Count; D013077:Sperm Head / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects*; D013082:Sperm Tail / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D000975:Antioxidants; D007306:Insecticides; D004726:Endosulfan; D001205:Ascorbic Acid