Recent advances in the neuropathology of multiple sclerosis.
Important insights from multiple sclerosis (MS) pathology have broadened our view of the disease during the last years. Details of the inflammatory response as well as mechanisms of demyelination were elucidated. Damage to neuronal processes was identified as the major predictor of persistent disability in MS patients. Abortive repair mechanisms are increasingly studied, and our increased understanding will pave the way to new therapeutic strategies. This overview highlights some of the current views on MS pathogenesis derived from human neuropathology.
Stadelmann
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Institute of Neuropathology, Robert-Koch-Strasse 40, 37099 Goettingen, Germany. c.stadelmann@med.uni-goettingen.de
D000818:Animals; D001369:Axons / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D003711:Demyelinating Diseases / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D009103:Multiple Sclerosis / Q000473:pathology*; D009186:Myelin Sheath / Q000502:physiology; D009420:Nervous System / Q000473:pathology*