Relationship among alcohol, body weight, and cardiovascular risk factors in 27,030 Korean men.
OBJECTIVE
Recent studies suggest a lower risk for overweight/obesity in moderate alcohol drinkers. However, the validity of this relationship and its impact on the putative benefits of alcohol consumption on cardiovascular disease (CVD) risk has not been well evaluated.


METHODS
We assessed the impact of BMI on the relationship between alcohol consumption and CVD risk factors (blood pressure, lipid panel, and glucose and insulin concentrations) in 27,030 healthy Korean men with no major comorbidities or medication intake seen in a large urban Korean hospital.


RESULTS
BMI and overweight prevalence increased linearly with alcohol intake (P < 0.001). Alcohol intake was also positively associated with blood pressure and triglyceride, HDL, and fasting glucose concentrations (P < 0.001) and negatively associated with LDL and insulin concentrations (P < 0.001). With nondrinkers as the reference group, the odds ratio for having insulin in the top quartile also declined linearly when adjusted for age, BMI, smoking, and exercise, with the heaviest drinkers (>40 g/day) having an odds ratio of 0.71 (95% CI 0.62-0.82) (P < 0.001). The relationship between alcohol and CVD risk factors was similar in normal-weight and overweight individuals.


CONCLUSIONS
Alcohol intake is associated with increasing BMI and several metabolic abnormalities, including higher fasting glucose. Paradoxically, it is also associated with lower insulin concentrations. The clinical significance of these findings needs further investigation.
Sung
Ki-Chul
KC
Department of Medicine, Sungkyunkwan University, Kangbuk Samsung Hospital, Seoul, Korea.
Kim
Sun H
SH
Reaven
Gerald M
GM
D000428:Alcohol Drinking / Q000453:epidemiology*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015444:Exercise; D006304:Health Status; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology; D007328:Insulin / Q000097:blood; D007723:Korea / Q000453:epidemiology; D008297:Male; D008499:Medical Records; D018579:Patient Selection; D015995:Prevalence; D012307:Risk Factors
D001786:Blood Glucose; D007328:Insulin