Acute ophthalmoparesis associated with anti-GM1, anti-GD1a, and anti-GD1b antibodies after enterovirus infection in a 6-year-old girl.
This article presents a 6-year-old girl who developed acute unilateral third cranial nerve palsy in the absence of any other sign of central nervous system involvement. Raised titers of immunoglobulin M antibodies against GM1, GD1a, and GD1b ganglioside components were demonstrated. Ten days earlier, the girl had experienced acute gastroenteritis with positive specific immunoglobulin M antibodies against enterovirus. The results of all other laboratory tests usually performed for infectious diseases were negative, and neuroradiologic findings were also normal. Oral prednisone was administered for a few days, and the ophthalmoparesis fully resolved within 1 month. Two months later, a second episode of isolated ophthalmoparesis occurred, again associated with a positive immunoglobulin M reaction against GM1, GD1a, and GD1b antigens. This report discusses the relationship between acute isolated ophthalmoparesis and antiganglioside antibodies.
Fusco
Carlo
C
Child Neurology Unit, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. Fusco.Carlo@asmn.re.it
Bertani
Gianna
G
Scarano
Angela
A
Giustina
Elvio Della
ED
D000906:Antibodies / Q000097:blood* / Q000276:immunology*; D002648:Child; D004769:Enterovirus Infections / Q000150:complications*; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D005732:Gangliosides / Q000145:classification / Q000276:immunology*; D006801:Humans; D009886:Ophthalmoplegia / Q000209:etiology / Q000276:immunology* / Q000821:virology
D000906:Antibodies; D005732:Gangliosides; C021298:ganglioside, GD1a; C033851:ganglioside, GD1b; D005677:G(M1) Ganglioside