Stereotypic circling behavior in mice with vestibular dysfunction: asymmetrical effects of intrastriatal microinjection of a dopamine agonist.
Bronx Waltzer (bv) mouse, which has been used as a model of hearing and vestibular dysfunction, shows remarkable repetitive circling behavior. This study investigated whether the behavior is caused by the asymmetry of striatal function by observing the behavior of the bv mice following microinjection of dopamine D1 agonist, A68930 into the striatum ipsilaterally and contralaterally to the preferred direction of rotation separately. High dose of the drug induced opposite effects on ipsilateral rotations by the side of injections with statistical significance (p = .0026). These results suggested that the stereotypic circling behavior involves striatum and is based on striatal asymmetry.
Ishiguro
Akio
A
Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan. akio-i@k4.dion.ne.jp
Inagaki
Masumi
M
Kaga
Makiko
M
D000818:Animals; D002839:Chromans / Q000494:pharmacology*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D018491:Dopamine Agonists / Q000494:pharmacology*; D007839:Functional Laterality; D020233:Gait Disorders, Neurologic / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008817:Mice, Mutant Strains; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects; D017072:Neostriatum / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D018709:Statistics, Nonparametric; D013239:Stereotyped Behavior / Q000187:drug effects*; D019956:Stereotypic Movement Disorder / Q000188:drug therapy / Q000503:physiopathology; D015837:Vestibular Diseases / Q000188:drug therapy / Q000503:physiopathology*; D014722:Vestibule, Labyrinth / Q000503:physiopathology
D002839:Chromans; D018491:Dopamine Agonists; C065380:A 68930; D004298:Dopamine