Bait and switch: synthetic GEFs divert an input signal to diverse cellular responses.
The Rho family GTPases regulate many cellular functions including the organization, mechanics, and dynamics of the actin cytoskeleton. Re-engineering the highly conserved autoinhibitory structure of GEFs, Yeh et al. (2007) generated novel synthetic proteins that regulated Rho GTPase signaling and cell morphology, highlighting the power of protein module engineering.
Chen
Christopher S
CS
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. chrischen@seas.upenn.edu
D008841:Actin Cytoskeleton / Q000502:physiology*; D000818:Animals; D005818:Genetic Engineering; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism*
D008840:Microfilament Proteins; D020741:rho GTP-Binding Proteins