title: Helical TomoTherapy in the treatment of central nervous system metastasis.
abstract: In this report the authors review the use of radiotherapy in the treatment of central nervous system (CNS) metastasis. They comment on different treatment methods for both intracranial and extracranial CNS metastasis and discuss some of the evidence supporting the use of radiotherapy in these settings. Recent advancements in radiation oncology technology are briefly reviewed with a focus on the advantages and disadvantages of helical TomoTherapy-based treatment strategies. A review of pertinent current literature was performed. TomoTherapy research currently underway at the University of Virginia Health System is discussed and a representative case is presented. Radiotherapy for CNS metastasis is an effective treatment that provides palliation of symptoms and confers a survival advantage on selected patients. Advances in radiotherapy techniques continue to improve the therapeutic ratio for patients with CNS metastases. Helical TomoTherapy offers distinct advantages for patients with CNS metastatic disease by sparing normal tissue when intracranial or extracranial disease is targeted.
authors.affiliation: Department of Radiation Oncology, University of Virginia Health System, Charlottesville, Virginia 22908, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Baisden
authors.forename: Stanley H
authors.initials: SH
authors.lastname: Benedict
authors.forename: Ke
authors.initials: K
authors.lastname: Sheng
authors.forename: Paul W
authors.initials: PW
authors.lastname: Read
authors.forename: James M
authors.initials: JM
authors.lastname: Larner
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D006801:Humans; D009362:Neoplasm Metastasis / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control / Q000532:radiotherapy; D011829:Radiation Dosage; D020266:Radiotherapy, Conformal / Q000295:instrumentation / Q000379:methods* / Q000592:standards*; D036542:Tomography, Spiral Computed / Q000379:methods* / Q000639:trends; D016896:Treatment Outcome