Relationship of adiponectin to serum paraoxonase 1.
Correlation of the plasma levels of insulin-sensitizing, anti-inflammatory and anti-atherosclerotic adiponectin with HDL has been demonstrated. However, its relation to HDL-bound paraoxonase 1 (PON1) has not been clarified. The association of serum PON1 activity with findings of metabolic syndrome was investigated in three age and sex-matched groups: (1) non-diabetic overweight subjects with BMI 28-39.9 kg/m(2) (n=25); (2) non-diabetic obese subjects with BMI>or=40 kg/m(2) (n=25); and (3) healthy, normal-weight controls (n=24). Of the parameters investigated, PON1 activity correlated positively with concentrations of HDL-C and adiponectin, and correlated negatively with BMI, waist circumference, systolic BP, levels of HbA(1C), and insulin, HOMA-IR, and TBARS. The positive correlation between adiponectin and PON1 remained significant even after adjustments for age, gender, BMI, blood pressure, HOMA-IR, HDL-C, LDL-C, and lipid peroxidation.


CONCLUSIONS
PON1 activity shows negative association with markers of metabolic syndrome. We demonstrate that adiponectin is an independent variable of serum PON1, which may contribute to the anti-atherosclerotic effect of adiponectin.
Bajnok
Laszlo
L
1st Department of Medicine, School of Medicine, University of Pécs, H-7624 Pécs, Ifjúság út 13, Hungary. Laszlo.Bajnok@aok.pte.hu
Csongradi
Eva
E
Seres
Ildiko
I
Varga
Zsuzsa
Z
Jeges
Sara
S
Peti
Attila
A
Karanyi
Zsolt
Z
Juhasz
Attila
A
Mezosi
Emese
E
Nagy
Endre V
EV
Paragh
Gyorgy
G
D052242:Adiponectin / Q000097:blood; D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D050197:Atherosclerosis / Q000378:metabolism*; D001794:Blood Pressure; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000378:metabolism*; D050177:Overweight / Q000378:metabolism
C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human