[Expression of calpain 1 and calpain 2 during the skin incised wound healing in mice].
OBJECTIVE
To investigate the expressions of calpain1 and calpain2 during the skin incised wound healing in mice.


METHODS
Expression of calpain1 and calpain2 was evaluated by immunohistochemical method.


RESULTS
Both calpain1 and calpain2 were expressed in the skin cells in the control groups. The calpain1 positive cells were remarkably increased and reached the maximal level in day 1 after skin incised wound, decreased after day 3, markedly increased again in day 5, and then gradually decreased from day 7 to 14; the calpain2 positive cells were significantly increased in day 1 and decreased to the minimum in day 3, markedly increased again in day 5, and then gradually decreased from day 7 to 10.


CONCLUSIONS
The changes of calpain1 and calpain2 expressions appear to be bimodal after incised wound of skin in mice.
Zhang
Wei
W
Department of forensic pathology, China Medical University, Shenyang 110001, China. zhangwei6968@sina.com
Guan
Da-Wei
DW
Zhao
Rui
R
Zhang
Jian-Jun
JJ
D000818:Animals; D017209:Apoptosis; D002154:Calpain / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D011897:Random Allocation; D012867:Skin / Q000293:injuries* / Q000378:metabolism*; D013194:Staining and Labeling; D013997:Time Factors; D014945:Wound Healing; D014947:Wounds and Injuries / Q000378:metabolism / Q000503:physiopathology
D002154:Calpain