title: Reversible folding-unfolding, aggregation protection, and multi-year stabilization, in high concentration protein solutions, using ionic liquids.
abstract: We report the reversible thermal unfolding/refolding, and long period stabilization against aggregation and hydrolysis, of >200 mg ml(-1) solutions of lysozyme in ionic liquid-rich, ice-avoiding, solvents.
authors.affiliation: Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
authors.forename: Nolene
authors.initials: N
authors.lastname: Byrne
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Wang
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Belieres
authors.forename: C Austen
authors.initials: CA
authors.lastname: Angell
mesh_terms: D007477:Ions; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D012996:Solutions
chemical_list: D007477:Ions; D011506:Proteins; D012996:Solutions