title: Infrared irradiation has potential antidepressant effect.
abstract: OBJECTIVE
  Light therapy was only partially effective in treatment of depression when compared with summer's sunlight. The antidepressant effect of infrared irradiation was evaluated using an experimental animal model.
  
  
  METHODS
  Seventeen mice were randomly assigned to the exposure group (n = 9) and the control group (n = 8). The mice in the exposure group received infrared irradiation for 60 min daily during the study period of 4 weeks. The two groups were given forced swim test once a week to evaluate depression with the measurement of the immobility time.
  
  
  RESULTS
  We found that the exposure group showed a tendency of less immobility time by the end of the 3rd week when compared with the control group, and at the end of 4th week the difference reached a statistical significance (t(15) = 2.873; p = 0.012).
  
  
  CONCLUSIONS
  The result indicates that the immobility time in forced swim test, the sign of depression, can be reduced after prolonged (4 weeks) exposure to infrared irradiation in the animal model. The result suggests that a continuous application of infrared irradiation has antidepressant effect.
authors.affiliation: Department of Psychiatry, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan. wccho5255@yahoo.com.tw
authors.forename: Jui-Feng
authors.initials: JF
authors.lastname: Tsai
authors.forename: Sigmund
authors.initials: S
authors.lastname: Hsiao
authors.forename: Sin-Yao
authors.initials: SY
authors.lastname: Wang
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003866:Depressive Disorder / Q000523:psychology / Q000628:therapy*; D005260:Female; D007259:Infrared Rays / Q000627:therapeutic use*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013550:Swimming / Q000523:psychology