Emerging minimal-change nephrotic syndrome in a patient with chronic mesangial proliferative lupus nephritis.
A 41-year-old Japanese woman with a 25-year history of systemic lupus erythematosus was admitted because of abrupt onset of nephrotic syndrome and acute renal failure. Renal biopsy specimen showed only mild mesangial proliferative glomerulonephritis associated with mesangial deposition of immunoglobulins/complements. No significant immune deposits were found in the glomerular capillary walls, but mild foot process effacement was observed on electron microscopy. Further, two-month corticosteroid therapy improved her massive proteinuria and renal dysfunction, indicating that this patient showed minimal-change nephropathy superimposed on mesangial proliferative lupus nephritis.
Deji
Naoko
N
Department of Internal Medicine, Shiga University of Medical Science, Otsu.
Sugimoto
Toshiro
T
Kanasaki
Masami
M
Aoyama
Masahiro
M
Tanaka
Yuki
Y
Sakaguchi
Masayoshi
M
Nishio
Yoshihiko
Y
Uzu
Takashi
T
Kashiwagi
Atsunori
A
D000208:Acute Disease; D000328:Adult; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D005260:Female; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D007677:Kidney Function Tests; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008181:Lupus Nephritis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D009402:Nephrosis, Lipoid / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D012720:Severity of Illness Index