title: Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position.
abstract: Novel oxazolidinone derivatives of the lead compound RBx 8700, containing methylene oxygen- and methylene sulfur-linked substituents at the C5-position, were synthesized. Antibacterial screening of these compounds against a panel of resistant and susceptible Gram-positive and fastidious Gram-negative bacteria gave compounds 2 and 4 as new antibacterial agents.
authors.affiliation: Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Laboratories Limited, Plot-20, Sector-18, Udyog Vihar, Gurgaon, India. sonali.rudra@ranbaxy.com
authors.forename: Sonali
authors.initials: S
authors.lastname: Rudra
authors.forename: Fnu
authors.initials: F
authors.lastname: Sangita
authors.forename: Arti
authors.initials: A
authors.lastname: Gujrati
authors.forename: Manisha
authors.initials: M
authors.lastname: Pandya
authors.forename: Pragya
authors.initials: P
authors.lastname: Bhateja
authors.forename: Tarun
authors.initials: T
authors.lastname: Mathur
authors.forename: Smita
authors.initials: S
authors.lastname: Singhal
authors.forename: Ashok
authors.initials: A
authors.lastname: Rattan
authors.forename: Mohammed
authors.initials: M
authors.lastname: Salman
authors.forename: Biswajit
authors.initials: B
authors.lastname: Das
mesh_terms: D000081:Acetamides / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria; D000069349:Linezolid; D013058:Mass Spectrometry; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D023303:Oxazolidinones / Q000737:chemistry*; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry*; D013696:Temperature; D013859:Thiocarbamates / Q000737:chemistry
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D010879:Piperazines; D013859:Thiocarbamates; D000077489:Piperazine; D013455:Sulfur; D000069349:Linezolid; D008712:Methicillin