title: Sacral nerve neuromodulation in patients with underlying neurologic disease.
abstract: OBJECTIVE
  Sacral nerve neuromodulation (SNS) is an effective treatment for lower urinary tract dysfunction. Many underlying neurologic processes affect lower urinary tract function. We present results of SNS in patients with underlying neurologic dysfunction.
  
  
  METHODS
  This is a retrospective case series of 33 patients with neurologic disease and lower urinary tract dysfunction who underwent an InterStim stimulation procedure. Results were evaluated by pre- and postoperative voiding diaries. Success was defined as greater than 50% improvement.
  
  
  RESULTS
  Twenty-eight of 33 patients (85%) underwent implantation: 13 of 16 (81%) multiple sclerosis, 4 of 6 (67%) Parkinson disease, and 11 of 11 (100%) other neurologic disorders. Incontinence episodes per 24 hours decreased 68%, number of voids per 24 hours decreased 43%, nocturia decreased 70%, and there was a 58% reduction in intermittent self-catheterization per 24 hours. Ninety-three percent reported overall satisfaction.
  
  
  CONCLUSIONS
  Sacral nerve neuromodulation is an effective treatment for lower urinary tract dysfunction in patients with underlying neurologic disease.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, University of California, Irvine, School of Medicine, Orange, CA 92868, USA. pwallace@uci.edu
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Wallace
authors.forename: Felicia L
authors.initials: FL
authors.lastname: Lane
authors.forename: Karen L
authors.initials: KL
authors.lastname: Noblett
mesh_terms: D000328:Adult; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D008160:Lumbosacral Plexus; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000150:complications*; D017060:Patient Satisfaction; D012189:Retrospective Studies; D016896:Treatment Outcome; D014555:Urination Disorders / Q000209:etiology / Q000628:therapy*