Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis.
Tuberculosis kills nearly 2 million people annually, and current approaches to tuberculosis control are expensive, have limited efficacy, and are vulnerable to being overcome by extensively drug-resistant strains of Mycobacterium tuberculosis. Determination of the genome sequence of M. tuberculosis has revolutionized tuberculosis research, contributed to major advances in the understanding of the evolution and pathogenesis of M. tuberculosis, and facilitated development of new diagnostic tests with increased specificity for tuberculosis. In this review, we describe some of the major progress in tuberculosis research that has resulted from knowledge of the genome sequence and note some of the problems that remain unsolved.
Ernst
Joel D
JD
Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016, USA. joel.ernst@med.nyu.edu
Trevejo-Nuñez
Giraldina
G
Banaiee
Niaz
N
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D005075:Biological Evolution; D023281:Genomics; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D014376:Tuberculosis / Q000175:diagnosis* / Q000235:genetics* / Q000382:microbiology / Q000635:transmission
D001426:Bacterial Proteins; D018398:Homeodomain Proteins