Abyssomicins G and H and atrop-abyssomicin C from the marine Verrucosispora strain AB-18-032.
Abyssomicin C is a complex polyketide-type antibiotic and the first natural inhibitor of the p-aminobenzoate biosynthesis produced by the marine Verrucosispora strain AB-18-032. We have now isolated three novel naturally produced abyssomicins, among them the even more active atrop-abyssomicin C. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy.
Keller
Simone
S
Institut für Chemie, FG Organische Chemie, Technische Universität Berlin, Germany.
Nicholson
Graeme
G
Drahl
Carmen
C
Sorensen
Erik
E
Fiedler
Hans-Peter
HP
Süssmuth
Roderich D
RD
D039903:Actinobacteria / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000302:isolation & purification*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D021241:Spectrometry, Mass, Electrospray Ionization
D000900:Anti-Bacterial Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D018942:Macrolides