title: Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain.
abstract: BACKGROUND
  Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain.
  
  
  METHODS
  Five mouse lines including C57BL/6, Balb/c, 129S6-Slc11a1tm1Mcg, 129S1/SvImJ, B6.129-Inpp5dtm1Rkh were used in the murine typhoid model to examine the dissemination of systemic Salmonella enterica serovar Typhimurium following oral infection.
  
  
  RESULTS
  We report data on spontaneous meningitis and brain infection following oral infection of mice with Salmonella enterica serovar Typhimurium.
  
  
  CONCLUSIONS
  This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried.
authors.affiliation: Michael Smith Laboratories, University of British Columbia, Vancouver, BC., Canada. m_wickham@mac.com <m_wickham@mac.com>
authors.forename: Mark E
authors.initials: ME
authors.lastname: Wickham
authors.forename: Nat F
authors.initials: NF
authors.lastname: Brown
authors.forename: John
authors.initials: J
authors.lastname: Provias
authors.forename: B Brett
authors.initials: BB
authors.lastname: Finlay
authors.forename: Brian K
authors.initials: BK
authors.lastname: Coombes
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D004660:Encephalitis / Q000382:microbiology / Q000473:pathology; D005260:Female; D016920:Meningitis, Bacterial / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D012481:Salmonella Infections, Animal / Q000503:physiopathology*; D012486:Salmonella typhimurium / Q000472:pathogenicity*