Recurrent pregnancy loss and thrombophilia.
In the last decades we found many data concerning the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL). Although first studies were focused only on the association between thrombophilia and RPL, subsequent studies underlined also a potential role of antithrombotic treatment to prevent vascular complication such as venous thromboembolism (VTE) during pregnancy. Now, emerging data seem to be available also on the role of active thromboprophylaxis with heparin and pregnancy outcome. This review will be focused on the recent knowledge between thrombophilia, hypercoagulable state, RPL, VTE and future perspectives.
Di Micco
Pierpaolo
P
Internal Medicine Division, Buonconsiglio Fatebenefratelli Hospital of Naples, Naples, Italy. pdimicco@libero.it
D'uva
Maristella
M
Strina
Ida
I
De Placido
Giuseppe
G
Di Fiore
Rosanna
R
Quaranta
Sandro
S
Castaldo
Giuseppe
G
D000026:Abortion, Habitual / Q000209:etiology* / Q000235:genetics; D016736:Antiphospholipid Syndrome / Q000175:diagnosis; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications / Q000235:genetics; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome; D019851:Thrombophilia / Q000150:complications* / Q000188:drug therapy* / Q000235:genetics; D054556:Venous Thromboembolism / Q000175:diagnosis / Q000188:drug therapy*
D006495:Heparin, Low-Molecular-Weight; D042965:Methylenetetrahydrofolate Reductase (NADPH2)