The road to non-heme oxoferryls and beyond.
Oxoiron(IV) species are often implicated in the catalytic cycles of oxygen-activating non-heme iron enzymes. The paucity of suitable model complexes stimulated us to fill this void, and our synthetic efforts have afforded a number of oxoiron(IV) complexes. This Account provides a chronological perspective of the observations that contributed to the generation of the first non-heme iron(IV)-oxo complexes in high yield and summarizes their salient properties to date.
Que
Lawrence
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Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, Minnesota 55455, USA.
D002264:Carboxylic Acids / Q000737:chemistry / Q000378:metabolism; D002384:Catalysis; D006639:Histidine / Q000737:chemistry / Q000378:metabolism; D007501:Iron / Q000737:chemistry* / Q000378:metabolism; D007656:Ketoglutaric Acids / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D010105:Oxygenases / Q000737:chemistry* / Q000378:metabolism; D013379:Substrate Specificity
D002264:Carboxylic Acids; D007656:Ketoglutaric Acids; D008024:Ligands; C066317:ferryl iron; D006639:Histidine; D007501:Iron; D010105:Oxygenases