title: Comparison of uptake between PureSorb-Q40 and regular hydrophobic coenzyme Q10 in rats and humans after single oral intake.
abstract: Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant and essential component of the mitochondrial electron transfer system in the body, and is in wide use as a functional food material and cosmetic raw material. However, as CoQ10 is extremely lipid-soluble, absorption by the body is not easy. In general, people use soft-gel capsules in which CoQ10 is suspended in oil, and take these capsules with food. PureSorb-Q40 (P40) was developed to improve CoQ10 processability and absorption when taken without food, and the present study compared the effects of food on absorption between P40 and conventional lipid-soluble CoQ10 in rats and humans. The results of a rat study showed higher uptake when P40 was administered in the fasting state or with food compared to lipid-soluble CoQ10. The results of a human study showed that uptake was favorable when P40 was administered in the fasting state, and even when administered postprandially, a significant difference was noted in uptake rate up to 6 h after intake and uptake volume up to 8 h after intake when compared to lipid-soluble CoQ10. These results show that any CoQ10 product using P40 can be quickly and reliably absorbed by the body regardless of dosage form or intake time.
authors.affiliation: Nisshin Pharma Inc., 25, Kanda-Nishiki-cho 1-chome, Chiyoda-ku, Tokyo 101-8441, Japan. nukuik@mail.ni-net.co.jp
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nukui
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamagishi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Miyawaki
authors.forename: Aikkarach
authors.initials: A
authors.lastname: Kettawan
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okamoto
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sato
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D002214:Capsules; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003067:Coenzymes / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D005502:Food; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D013607:Tablets; D013997:Time Factors; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D014815:Vitamins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000975:Antioxidants; D002214:Capsules; D003067:Coenzymes; C522292:PureSorb-Q40; D013607:Tablets; D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10