title: Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa.
abstract: During pregnancy, specific variants of Plasmodium falciparum-infected erythrocytes (IEs) can accumulate in the placenta through adhesion to chondroitin sulfate A (CSA) mediated by expression of PfEMP1 encoded by var2csa-type genes. Antibodies against these variants are associated with protection from maternal malaria. We evaluated antibodies among Kenyan, Papua New Guinean, and Malawian men and Kenyan children against two different CSA-binding P. falciparum isolates expressing var2csa variants. Specific IgG was present at significant levels among some men and children from each population, suggesting exposure to these variants is not exclusive to pregnancy. However, the level and prevalence of antibodies was substantially lower overall than exposed multigravidas. IgG-binding was specific and did not represent antibodies to subpopulations of non-CSA-binding IEs, and some sera inhibited IE adhesion to CSA. These findings have significant implications for understanding malaria pathogenesis and immunity and may be significant for understanding the acquisition of immunity to maternal malaria.
authors.affiliation: Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia. beeson@wehi.edu.au
authors.forename: James G
authors.initials: JG
authors.lastname: Beeson
authors.forename: Francis
authors.initials: F
authors.lastname: Ndungu
authors.forename: Kristina E M
authors.initials: KE
authors.lastname: Persson
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Chesson
authors.forename: Greg L
authors.initials: GL
authors.lastname: Kelly
authors.forename: Sophie
authors.initials: S
authors.lastname: Uyoga
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Hallamore
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Williams
authors.forename: John C
authors.initials: JC
authors.lastname: Reeder
authors.forename: Graham V
authors.initials: GV
authors.lastname: Brown
authors.forename: Kevin
authors.initials: K
authors.lastname: Marsh
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology*; D000953:Antigens, Protozoan / Q000276:immunology*; D002648:Child; D003430:Cross-Sectional Studies; D004912:Erythrocytes / Q000469:parasitology*; D005260:Female; D006801:Humans; D007630:Kenya; D016778:Malaria, Falciparum / Q000276:immunology* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010219:Papua New Guinea; D010920:Placenta / Q000469:parasitology; D010963:Plasmodium falciparum / Q000276:immunology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000276:immunology* / Q000469:parasitology
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; C512601:VAR2CSA protein, Plasmodium falciparum