Molecular genetic analysis of haematological malignancies II: Mature lymphoid neoplasms.
Molecular genetic techniques have become an integral part of the diagnostic assessment for many lymphomas and other chronic lymphoid neoplasms. The demonstration of a clonal immunoglobulin or T cell receptor gene rearrangement offers a useful diagnostic tool in cases where the diagnosis is equivocal. Molecular genetic detection of other genomic rearrangements may not only assist with the diagnosis but can also provide important prognostic information. Many of these rearrangements can act as molecular markers for the detection of low levels of residual disease. In this review, we discuss the applications of molecular genetic analysis to the chronic lymphoid malignancies. The review concentrates on those disorders for which molecular genetic analysis can offer diagnostic and/or prognostic information.
Bench
A J
AJ
Haemato-Oncology Diagnostic Service, Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. anthony.bench@addenbrookes.nhs.uk
Erber
W N
WN
Follows
G A
GA
Scott
M A
MA
D002051:Burkitt Lymphoma / Q000235:genetics; D015321:Gene Rearrangement; D006801:Humans; D007074:Immunoglobulin G / Q000235:genetics; D007943:Leukemia, Hairy Cell / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics; D015463:Leukemia, Prolymphocytic / Q000235:genetics; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008224:Lymphoma, Follicular / Q000235:genetics; D020522:Lymphoma, Mantle-Cell / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000235:genetics*; D025202:Molecular Diagnostic Techniques; D011948:Receptors, Antigen, T-Cell / Q000235:genetics
D007074:Immunoglobulin G; D011948:Receptors, Antigen, T-Cell