A dog with myelodysplastic syndrome: chronic myelomonocytic leukemia.
An eleven-year-old female pug was referred to Yamaguchi University Animal Hospital for evaluation of anemia and thrombocytopenia. The cytological examination of the peripheral blood showed some giant monocytic lineage blast cells. A few granulocytes and platelets had dysplastic features. On day 7, in addition to increasing the monocytic lineage cells, the dysplastic features of the blood had also increased compared to the initial examination. We performed bone marrow aspiration upon her death. The bone marrow revealed dysplastic features in all three hematopoietic cell lines, and an increase in the monocytic cell line. Based on the features of the bone marrow and the peripheral blood, this case was confirmed to be myelodysplastic syndrome--Chronic myelomonocytic leukaemia (MDS-CMML).
Hiraoka
Hiroko
H
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan.
Hisasue
Masaharu
M
Nagashima
Naho
N
Miyama
Takako
T
Tanimoto
Takashi
T
Watanabe
Malaika
M
Itamoto
Kazuhito
K
Mizuno
Takuya
T
Inokuma
Hisashi
H
Okuda
Masaru
M
D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004285:Dogs; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
D007166:Immunosuppressive Agents; D016572:Cyclosporine