Synthesis of heat shock proteins (HSP70) in blood leukocytes as a criterion of the resistance to stress injury.
The resistance of August rats to ulceration of the gastric mucosa induced by acute emotional stress was higher than in Wistar rats. August rats exhibited not only more potent activation of the protective nitric oxide system and mobilization of the immune system, but also increased synthesis of cytoprotective heat shock proteins HSP70 in blood leukocytes under stress conditions. Our results indicate that HSP70 protein synthesis in blood leukocytes during stress reflects organism's resistance to stress and, probably, to other adverse factors.
Pshennikova
M G
MG
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. niiopp@mail.ru
Zelenina
O M
OM
Kruglov
S V
SV
Pokidyshev
D A
DA
Shimkovich
M V
MV
Malyshev
I Yu
IY
D000818:Animals; D002478:Cells, Cultured; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis* / Q000502:physiology; D007962:Leukocytes / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000097:blood / Q000502:physiology; D009573:Nitrites / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D013315:Stress, Psychological
D018840:HSP70 Heat-Shock Proteins; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide