[DNA microarrays: technology and new insights in oncology].
BACKGROUND
Large-scale genomic studies based on DNA microarrays improve our understanding of the pathophysiology of cancers. The use of these research findings to improve diagnosis, prognosis and treatment is the current challenge of research in genomics.


METHODS
The article briefly describes the DNA microarrays technology and use in oncology and underlines the steps required to translate research findings of correlations between gene expression and type of cancer, outcome or response to chemotherapy into robust clinical tools.


CONCLUSIONS
Genomic technologies available today are sufficient to develop useful molecular markers for individual patient management.
Minvielle
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Inserm U601, laboratoire d'hématologie, institut de biologie, centre hospitalier universitaire de Nantes, 9, quai Moncousu, 44093 Nantes cedex 01, France. sminvielle@chu-nantes.fr
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm