title: Tongue base metastasis from neuroendocrine endometrial small cell carcinoma.
abstract: The endometrial small cell carcinoma (ESCC) is a rare and aggressive malignancy with an estimated prevalence of less than 1% of endometrial carcinomas. Endometrial small cell carcinoma is frequently diagnosed at an advanced stage and has a poor prognosis. Although the most common presenting sign of ESCC is definitely a peri- or postmenopausal vaginal bleeding, we report for the first time the occurrence of tongue base bleeding as first manifestation of disseminated neuroendocrine ESCC. From a clinical viewpoint, tongue metastasis from primary endometrial carcinoma is a manifestation of widespread disease. Albeit, our patient underwent complete hysterectomy and postoperative chemotherapy, she died of disseminated disease 3 months after ESCC diagnosis.
authors.affiliation: Section of Otolaryngology, Department of Medical and Surgical Specialties, University of Padova, Padova, Italy. gino.marioni@unipd.it
authors.forename: Gino
authors.initials: G
authors.lastname: Marioni
authors.forename: Marina
authors.initials: M
authors.lastname: Savastano
authors.forename: Laura
authors.initials: L
authors.lastname: Mattiello
authors.forename: Haralabos
authors.initials: H
authors.lastname: Koussis
authors.forename: Silvia
authors.initials: S
authors.lastname: Carpenè
authors.forename: Filippo
authors.initials: F
authors.lastname: Marino
authors.forename: Alberto
authors.initials: A
authors.lastname: Staffieri
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014062:Tongue Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*
chemical_list: D000970:Antineoplastic Agents