Applications of total synthesis toward the discovery of clinically useful anticancer agents.
This tutorial review provides a historical sampling of synthetic efforts undertaken in our laboratory, which have led to the total syntheses of a range of small molecule natural products of potential interest in oncology. It has become evident that natural products, and structures clearly derivable from natural products, have a remarkable record in the treatment of cancer at the clinical level. It is likely that, with the growing power of chemical synthesis, small molecule natural products will play a continuing role in providing lead anticancer compounds.
Wilson
Rebecca M
RM
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York 10021, USA.
Danishefsky
Samuel J
SJ
D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis / Q000737:chemistry; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry; D008937:Mitomycins / Q000138:chemical synthesis / Q000737:chemistry; D050257:Tubulin Modulators / Q000138:chemical synthesis / Q000737:chemistry
D047151:Amaryllidaceae Alkaloids; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D007546:Isoquinolines; D018942:Macrolides; D008937:Mitomycins; D050257:Tubulin Modulators; C044997:pancratistatin