title: Metabolically labile cannabinoid esters: a 'soft drug' approach for the development of cannabinoid-based therapeutic drugs.
abstract: Biphenylic ester derivatives, designed by using a 'soft-drug' approach, proved to possess good binding properties toward cannabinoid CB(1) and CB(2) receptors and, at the same time, their metabolically labile ester portion would promote a rapid systemic inactivation. This may constitute a possible solution to the psychotropic side effects encountered when cannabinoids are therapeutically employed as local analgesic or antiglaucoma agents.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Pisa, Via Bonanno 6, 56126, Pisa, Italy. minutolo@farm.unipi.it
authors.forename: F
authors.initials: F
authors.lastname: Minutolo
authors.forename: M G
authors.initials: MG
authors.lastname: Cascio
authors.forename: I
authors.initials: I
authors.lastname: Carboni
authors.forename: T
authors.initials: T
authors.lastname: Bisogno
authors.forename: G
authors.initials: G
authors.lastname: Prota
authors.forename: S
authors.initials: S
authors.lastname: Bertini
authors.forename: M
authors.initials: M
authors.lastname: Digiacomo
authors.forename: M
authors.initials: M
authors.lastname: Bifulco
authors.forename: V
authors.initials: V
authors.lastname: Di Marzo
authors.forename: M
authors.initials: M
authors.lastname: Macchia
mesh_terms: D000700:Analgesics / Q000737:chemistry; D000818:Animals; D002186:Cannabinoids / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004952:Esters / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008956:Models, Chemical; D051381:Rats; D043882:Receptors, Cannabinoid / Q000378:metabolism*
chemical_list: D000700:Analgesics; D002186:Cannabinoids; D002264:Carboxylic Acids; D004952:Esters; D008024:Ligands; D043882:Receptors, Cannabinoid