Malignant transformation of T-cell large granular lymphocyte leukemia in a dog.
An 8-year-old spayed female Golden Retriever was referred to us for evaluation of mild lymphocytosis. The peripheral lymphocytes were comprised of mostly large granular lymphocytes (LGLs), and flow cytometry showed that they were mostly CD3+8+ T lymphocytes. Clonal rearrangement of the T-cell receptor gene was identified in the peripheral blood, and the dog was therefore diagnosed with LGL chronic leukemia. The dog was subclinical without treatment until hospitalization on day 154, at which point the lymphocytes looked like lymphoblasts and the surface markers changed to CD3-8-. This was regarded as malignant transformation from LGL chronic leukemia to the acute type. Sequential chemotherapy was started, but the dog died on day 190. Necropsy revealed tumor cell infiltration into the heart, skin, and brain.
Takahashi
Tomoko
T
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Yamaguchi, Japan.
Otani
Isao
I
Okuda
Masaru
M
Inoue
Masashi
M
Ito
Kanako
K
Sakai
Manabu
M
Koie
Hiroshi
H
Yamaya
Yoshiki
Y
Watari
Toshihiro
T
Sato
Tsuneo
T
Kanayama
Kiichi
K
Tokuriki
Mikihiko
M
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D015458:Leukemia, T-Cell / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D013997:Time Factors
D000970:Antineoplastic Agents