Pharmacogenomics and serotonergic agents: research observations and potential clinical practice implications.
Pharmacogenomics of serotonin are potentially relevant in research and clinical practice. There are few proven examples of the importance of pharmacogenetics of serotonin-modifying agents used in functional gastrointestinal or motility disorders. Drug metabolism is dependent on function of the cytochrome P450 enzymes, such as 2D6 and 3A4. Genetic variations in transporters and translation mechanisms have been associated with responses to treatment in irritable bowel syndrome and in obesity. Research on the impact of polymorphisms of key proteins on the pharmacokinetics and pharmacodynamics of drugs that alter serotonin-mediated signalling will assist in explaining diverse responses to those drugs and ultimately improve clinical practice, individualizing medicine.
Camilleri
M
M
CENTER Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. camilleri.michael@mayo.edu
D001067:Appetite Depressants / Q000378:metabolism / Q000627:therapeutic use; D002243:Carbolines / Q000378:metabolism / Q000627:therapeutic use; D003503:Cyclobutanes / Q000378:metabolism / Q000627:therapeutic use; D004415:Dyspepsia / Q000188:drug therapy / Q000235:genetics; D005765:Gastrointestinal Agents / Q000378:metabolism / Q000627:therapeutic use; D014644:Genetic Variation; D006801:Humans; D007211:Indoles; D009765:Obesity / Q000188:drug therapy; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D011985:Receptors, Serotonin / Q000235:genetics / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D018490:Serotonin Agents / Q000378:metabolism* / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000378:metabolism / Q000627:therapeutic use; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000378:metabolism / Q000627:therapeutic use
D001067:Appetite Depressants; D002243:Carbolines; D003503:Cyclobutanes; D005765:Gastrointestinal Agents; D007211:Indoles; D011985:Receptors, Serotonin; D018490:Serotonin Agents; D012702:Serotonin Antagonists; D050486:Serotonin Plasma Membrane Transport Proteins; D017366:Serotonin Receptor Agonists; C090840:alosetron; D012701:Serotonin; C105050:tegaserod; C058254:sibutramine