[Impact of CYP3A7*1C polymorphism on bone mineral content in postmenopausal women].
BACKGROUND
CYP3A7*1C polymorphism has been shown to be associated with lower levels of serum dehydroepiandrosterone sulphate in men. The age-related decline of dehydroepiandrosterone sulphate levels is believed to contribute to the development of osteoporosis. We hypothesized that CYP3A7*1C may lead to bone loss through decreased levels of dehydroepiandrosterone sulphate in postmenopausal women.


METHODS
319 postmenopausal women were studied and divided into two subgroups: 217 women with osteoporosis and 102 aged-matched women without osteoporosis. The CYP3A7*1C polymorphism was genotyped. Serum dehydroepiandrosterone sulphate levels and bone mineral density were measured.


RESULTS
Homozygous CYP3A7*1C carriers had significantly lower bone mineral density at lumbar spine than that of wild type (T-score with CYP3A7*1C mutant type: -3.27 +/- 1.02, T-score with wild type: -1.35 +/- 1.53, p = 0.041) after adjusting for age and DHEAS levels. No association was found between genotypes and dehydroepiandrosterone sulphate levels.


CONCLUSIONS
Our data suggest that CYP3A7 polymorphism might have an influence on bone mass at the lumbar spine independently of serum dehydroepiandrosterone sulphate concentrations.
Bácsi
Krisztián
K
Semmelweis Egyetem, Altalános Orvostudományi Kar, I. Belgyógyászati Klinika, Korányi S. u. 2/a, 1083 Budapest. bacsi@bel1.sote.hu
Kósa
János
J
Lazáry
Aron
A
Balla
Bernadett
B
Horváth
Henrik
H
Takács
István
I
Nagy
Zsolt
Z
Speer
Gábor
G
Lakatos
Péter
P
D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D015519:Bone Density / Q000235:genetics; D016022:Case-Control Studies; D051544:Cytochrome P-450 CYP3A; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D008159:Lumbar Vertebrae / Q000378:metabolism; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D019314:Dehydroepiandrosterone Sulfate; D001189:Aryl Hydrocarbon Hydroxylases; C103123:CYP3A7 protein, human; D051544:Cytochrome P-450 CYP3A