title: Aqueous sodium dehydrocholate-sodium deoxycholate mixtures at low concentration.
abstract: The behavior of the sodium dehydrocholate (NaDHC)-sodium deoxycholate (NaDC) mixed system was studied by a battery of methods that examine effects caused by the different components of the system: monomers, micelles, and both components. The behavior of the mixed micellar system was studied by the application of Rubingh's model. The obtained results show that micellar interaction was repulsive when the aggregates were rich in NaDHC. The gradual inclusion of NaDC in micelles led to a structural transformation in the aggregates and the interaction became attractive. The bile salts' behavior in mixed monolayers at the air-solution interface was also investigated. Mixed monolayers are monotonically rich in NaDC, giving a stable and compact adsorbed layer. Results have shown that the interaction in both micelles and monolayer is not ideal and such behavior is assumed to be due to a structural factor in their hydrocarbon backbone.
authors.affiliation: Departamento de Química, Universidad Nacional del Sur, (8000) Bahía Blanca, Argentina.
authors.forename: Marcos D
authors.initials: MD
authors.lastname: Fernández-Leyes
authors.forename: Paula V
authors.initials: PV
authors.lastname: Messina
authors.forename: Pablo C
authors.initials: PC
authors.lastname: Schulz
mesh_terms: D000327:Adsorption; D000388:Air; D001647:Bile Acids and Salts / Q000737:chemistry; D002627:Chemistry, Physical / Q000379:methods; D003685:Dehydrocholic Acid / Q000737:chemistry / Q000494:pharmacology*; D003840:Deoxycholic Acid / Q000494:pharmacology*; D004553:Electric Conductivity; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D008958:Models, Molecular; D015233:Models, Statistical; D008968:Molecular Conformation
chemical_list: D001647:Bile Acids and Salts; D008823:Micelles; D003840:Deoxycholic Acid; D003685:Dehydrocholic Acid