title: [The efficacy of biological dressing containing calcium and magnesium on the management of hydrofluoric acid burns].
abstract: OBJECTIVE
  To observe the efficacy of biological dressing containing calcium and magnesia (sheep dermis absorbing calcium and magnesia and cross-link with glutaraldehyde) on the management of hydrofluoric acid burns in rats and patients.
  
  
  METHODS
  Wistar rats were randomly divided into A ( n = 24, normal control, with isotonic saline dressing after burns), B ( n = 32, with isotonic saline dressing treatment after hydrofluoric acid burns), C ( n = 32, with wet-dressing treatment after hydrofluoric acid burns), and D ( n = 32, with biological dressing treatment after hydrofluoric acid burns) groups. The rats in the latter 3 groups were inflicted with 3 cm x 3 cm TBSA full-thickness burns, and mortality, concentration of blood calcium , histopathological observation were carried out at 4,8,24 and 72 postburn hours (PBH), with 8 rats at each time-points. In addition, 46 patients with hydrofluoric acid burns were divided into E (with wet-dressing treatment) and F (with biological dressing treatment) groups to compare the curative effect.
  
  
  RESULTS
  The mortality in A,B,C,D groups were 0,31.2% ,15. 6% ,6. 2% , respectively. The wound in B group was deepened gradually after burns, but that in D group was slighter when compared with that in C group. The concentration of blood calcium in A group was higher than that in B, C and D groups at each time-points, and that in D groups was higher than that in B and C groups. The concentration of blood calcium in D group at 8 and 24 PBH were [(2.215 +/-0.008) ,(2.216 +/-0.008) mmol/L], which were obviously higher than those in B [(1.813 +/-0.017),(1.912 +/-0.013)mmol/L l] and C [(2.015 +/-0.006), (2.018 +/-0. 010)mmol/L] groups, (P <0. 01). The clinical outcome in E group was much better than that in F group.
  
  
  CONCLUSIONS
  Biological dressing containing calcium and magnesium can be applied in the emergency management and following treatment after hydrofluoric acid burns.
authors.affiliation: Department of Burns, the Third Affiliated Hospital of Inner Mongolia Medical College , Baotou 014010, PR China
authors.forename: Ling-feng
authors.initials: LF
authors.lastname: Wang
authors.forename: Guo-lin
authors.initials: GL
authors.lastname: Hu
authors.forename: Zhi-jian
authors.initials: ZJ
authors.lastname: Zhang
authors.forename: Te
authors.initials: T
authors.lastname: Ba
authors.forename: Zhi-dong
authors.initials: ZD
authors.lastname: Rong
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Sheng-jun
authors.initials: SJ
authors.lastname: Cao
authors.forename: Guo-hua
authors.initials: GH
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000818:Animals; D001684:Biological Dressings; D002057:Burns, Chemical / Q000628:therapy*; D002118:Calcium / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D006858:Hydrofluoric Acid; D008274:Magnesium / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D051381:Rats
chemical_list: D008274:Magnesium; D006858:Hydrofluoric Acid; D002118:Calcium