Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists.
A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPARgamma. The best PPARgamma agonist in this series was 9h, which showed an EC(50) value of 15 nM.
Ahn
Jin Hee
JH
Bioorganic Science Division, Korea Research Institute of Chemical Technology, Yuseong-Gu, Daejeon 305-600, Republic of Korea. jhahn@krict.re.kr
Shin
Mi Sik
MS
Jung
Sun Ho
SH
Kim
Jin Ah
JA
Kim
Hye Min
HM
Kim
Se Hoan
SH
Kang
Seung Kyu
SK
Kim
Kwang Rok
KR
Rhee
Sang Dal
SD
Park
Sung Dae
SD
Lee
Jae Mok
JM
Lee
Jeong Hyung
JH
Cheon
Hyae Gyeong
HG
Kim
Sung Soo
SS
D007192:Indenes / Q000737:chemistry* / Q000494:pharmacology*; D047495:PPAR gamma / Q000819:agonists*; D013329:Structure-Activity Relationship
D007192:Indenes; D047495:PPAR gamma