Novel delivery methods to achieve immunomodulation.
Immunomodulation in infectious diseases, cancer, cardiovascular disease and autoimmunity can now be targeted by sophisticated protein design, altering cellular responses by increasing therapeutic cell numbers ex vivo and then reimplanting, or altering cell function by gene transfer of cells ex vivo. In the last year, vaccination has been applied to modulate responses to autoantigens, allergens, viral or cancer antigens. The application of these technologies has entered the clinical arena and is having a positive impact on the treatment and prevention of human diseases.
Gould
David J
DJ
Bone and Joint Research Unit, William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine and Dentistry, University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom.
Chernajovsky
Yuti
Y
D015551:Autoimmunity / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000276:immunology; D003141:Communicable Diseases / Q000188:drug therapy / Q000276:immunology; D016503:Drug Delivery Systems; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology; D011506:Proteins / Q000008:administration & dosage*; D013601:T-Lymphocytes / Q000276:immunology; D014612:Vaccines / Q000276:immunology; D014780:Viruses / Q000235:genetics
D007155:Immunologic Factors; D011506:Proteins; D014612:Vaccines