title: TT virus infection: role of interferons, interleukin-28 and 29, cytokines and antiviral proteins.
abstract: In 1997 a novel virus in the serum of a patient with acute post-transfusion hepatitis of non A-G etiology was identified. This agent was designed TT virus (TTV). It produces persistent viremia and no disease, but the mechanism of its persistence is poorly understood. In the present study mRNA expression of antiviral proteins as MxA, 2' 5' OAS, anti-apopotic protein, cytokines IL- 28, IL- 29 and IFN are examined in a subject affected by B lymphoma and positive for TTV DNA and RNA in this cellular subset, and in BJAB and Dohh2 cell lines.
authors.affiliation: National Institute of Infectious Diseases, Lazzaro Spallanzani, Rome, Italy.
authors.forename: A R
authors.initials: AR
authors.lastname: Garbuglia
authors.forename: F
authors.initials: F
authors.lastname: Grasso
authors.forename: M G
authors.initials: MG
authors.lastname: Donà
authors.forename: S
authors.initials: S
authors.lastname: Mochi
authors.forename: P
authors.initials: P
authors.lastname: Conti
authors.forename: M A
authors.initials: MA
authors.lastname: De Lutiis
authors.forename: C
authors.initials: C
authors.lastname: Giorgi
authors.forename: T
authors.initials: T
authors.lastname: Iezzi
mesh_terms: D045744:Cell Line, Tumor; D002478:Cells, Cultured; D016207:Cytokines / Q000502:physiology*; D004266:DNA Virus Infections / Q000276:immunology / Q000473:pathology* / Q000821:virology; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000502:physiology*; D022783:Torque teno virus / Q000276:immunology*; D000095022:Interferon Lambda
chemical_list: D016207:Cytokines; D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C511668:interferon-lambda protein, mouse