title: Manganese accumulation in the brain: MR imaging.
abstract: Manganese (Mn) accumulation in the brain is detected as symmetrical high signal intensity in the globus pallidi on T1-weighted MR images without an abnormal signal on T2-weighted images. In this review, we present several cases of Mn accumulation in the brain due to acquired or congenital diseases of the abdomen including hepatic cirrhosis with a portosystemic shunt, congenital biliary atresia, primary biliary cirrhosis, congenital intrahepatic portosystemic shunt without liver dysfunction, Rendu-Osler-Weber syndrome with a diffuse intrahepatic portosystemic shunt, and patent ductus venosus. Other causes of Mn accumulation in the brain are Mn overload from total parenteral nutrition and welding-related Mn intoxication.
authors.affiliation: Department of Radiology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan. uchino@med.saga-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Uchino
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.forename: K
authors.initials: K
authors.lastname: Nomiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Takase
authors.forename: T
authors.initials: T
authors.lastname: Nakazono
authors.forename: J
authors.initials: J
authors.lastname: Nojiri
authors.forename: S
authors.initials: S
authors.lastname: Kudo
mesh_terms: D001927:Brain Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D008345:Manganese