title: Potential predictive factors of positive prostate biopsy in the Japanese population.
abstract: BACKGROUND
  There are numerous arguments for the predictive factors of positive prostate biopsies, differing according to race and region. This study aimed to determine predictive factors for a positive prostate biopsy in East Asian, especially Japanese men, using clinical, laboratory, and transrectal ultrasound (TRUS) findings.
  
  
  METHODS
  Data were collected from 466 men who underwent a prostate biopsy for suspected prostate cancer. Variables analyzed including age, digital rectal examination (DRE) findings, prostate-specific antigen (PSA) level, PSA density, prostate volume, and TRUS findings. Logistic regression analysis and the Mann-Whitney U test were used for this study.
  
  
  RESULTS
  Logistic regression analysis showed that significant predictors for a positive prostate biopsy for all patients were positive DRE results, prostate volume, and hypoechoic lesions on TRUS. Especially in the patients with PSA levels <10 ng/ml, the significant predictor for positive biopsy was prostate volume. The Mann-Whitney U test showed that significant predictors for a positive prostate biopsy in all patients were PSA density >0.15, positive DRE results, and prostate volume <25 cm(3). Especially in patients with PSA levels <10 ng/ml, significant predictors for a positive prostate biopsy were prostate volume <25 cm(3) and PSA density >0.15. Additionally, even if the data were confined to those patients with seven or more core biopsies, all the predictive factors shown in all patients were significant predictors in this category.
  
  
  CONCLUSIONS
  This study investigated potential predictors for positive prostate biopsy and demonstrated that prostate volume was an independent predictive factor for positive prostate biopsy in patients with PSA levels <10 ng/ml. In the future, we may be able to use our findings to create a nomogram for predicting positive prostate biopsy in Japanese men.
authors.affiliation: Department of Urology, Nishiwaki Municipal Hospital, Nishiwaki, Japan. katsumiatlanta@hotmail.com
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shigemura
authors.forename: Soichi
authors.initials: S
authors.lastname: Arakawa
authors.forename: Kunito
authors.initials: K
authors.lastname: Yamanaka
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yasui
authors.forename: Shigeji
authors.initials: S
authors.lastname: Matsubara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Iwamoto
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kataoka
authors.forename: Keiji
authors.initials: K
authors.lastname: Yuien
authors.forename: Masato
authors.initials: M
authors.lastname: Fujisawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D006801:Humans; D007564:Japan; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D011237:Predictive Value of Tests; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014463:Ultrasonography