Novel chloroenyne-modified amino acid derivatives.
Three groups of chloroenyne-modified amino acids were synthesized. Chloroenyne moiety was attached at the N- or C-terminal amino acid (Tyr, Phe, Val, Gly, Lys) position carrying different protecting groups. Prepared derivatives will be used as building blocks in the synthesis of enediyne-peptide conjugates. Furthermore, reactivity of modified amino acids in the peptide bond formation reaction was tested.
Gredicak
M
M
Division of Organic Chemistry and Biochemistry, Ruder Bos ković Institute, Zagreb, Croatia.
Kolonić
A
A
Jerić
I
I
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
D000596:Amino Acids; D010455:Peptides