title: Interruption of the blood supply of femoral head: an experimental study on the pathogenesis of Legg-Calve-Perthes Disease.
abstract: BACKGROUND
  The etiology of LCPD still is not clear. Thrombosis has been accused in the pathogenesis of LCPD but it is not proven until now. The aim of this study is to evaluate the results of single episode of obstruction of blood supply to the femoral heads of dogs.
  
  
  METHODS
  Blood supply femoral heads of 45 dogs was interrupted with embolisation with gel foam. The radiologic appearances, macroscopic and microscopic specimes of the hips were evaluated and compared with the human specimens of 15 LCPD patients obtained at the time of femoral osteotomies.
  
  
  RESULTS
  After one infarct, we demonstrated changes in femoral heads of puppies showing close resemblance to the findings of LCPD in human.
  
  
  CONCLUSIONS
  Obstruction of the femoral head caused by single artificial emboli caused changes in the femoral head similar to LCPD. The cause of the obstruction is obscure, intravascular and/or extravascular pathologies need specific attention, further studies focusing especially on the coagulation system are needed.
authors.affiliation: Faculty of Medicine, Department of Orthopaedics and Traumatology, Hacettepe University, Zemin kat, Ankara 06100, Turkey.
authors.forename: A Mumtaz
authors.initials: AM
authors.lastname: Alpaslan
authors.forename: M Cemalettin
authors.initials: MC
authors.lastname: Aksoy
authors.forename: Muharrem
authors.initials: M
authors.lastname: Yazici
mesh_terms: D000818:Animals; D004285:Dogs; D005270:Femur Head / Q000098:blood supply*; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D011859:Radiography