A novel class of metal-directed supramolecular DNA-delivery systems.
The bis-complexes [Cu(L(dt))(2)](OTf)(2) (1) and [Cu(L(ot))(2)](OTf)(2) (2), where L(dt) = 1-dodecyl-1,4,7-triazacyclononane, L(ot) = 1-octadecyl-1,4,7-triazacyclononane and OTf = trifluoromethanesulfonate, formed a novel class of metallo-liposomes in water that transfect pEGFP-N1 plasmids into HEK 293-T cells at 38% and 4% efficiency, respectively.
Cruz-Campa
Itzia
I
Department of Chemistry, University of Texas, El Paso, TX 79968, USA.
Arzola
Alejandro
A
Santiago
Lynn
L
Parsons
Jason G
JG
Varela-Ramirez
Armando
A
Aguilera
Renato J
RJ
Noveron
Juan C
JC
D002460:Cell Line; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D016503:Drug Delivery Systems; D005822:Genetic Vectors / Q000737:chemistry; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry* / Q000493:pharmacokinetics; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry*; D014162:Transfection / Q000379:methods
D008081:Liposomes; D009942:Organometallic Compounds; D003300:Copper; D004247:DNA