title: Structurally-defined direct C-magnesiation and C-zincation of N-heterocyclic aromatic compounds using alkali-metal-mediated metallation.
abstract: Demonstrating direct synergic "low polarity metallation", 1-methylindole is C-magnesiated by (TMEDA)(2).Na(2)MgBu(4) and C-zincated by (TMEDA).Na((t)Bu)(TMP)Zn((t)Bu), and 1-methylpyrrole is C-zincated by the same reagent, with all three metal products successfully crystallographically characterised.
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK G1 1XL.
authors.forename: Ben
authors.initials: B
authors.lastname: Conway
authors.forename: Eva
authors.initials: E
authors.lastname: Hevia
authors.forename: Alan R
authors.initials: AR
authors.lastname: Kennedy
authors.forename: Robert E
authors.initials: RE
authors.lastname: Mulvey