Dystrophin-deficient muscular dystrophy in a Weimaraner.
A 2-year-old, male Weimaraner with muscular dystrophy was presented with generalized muscle atrophy of the limbs; hypertrophy of the neck, infraspinatus, and lingual muscles; dysphagia; and regurgitation. Unilateral cryptorchidism, unilateral renal agenesis, and hiatal hernia were also detected. Spontaneous muscle activity was identified on myography. Serum creatine kinase was markedly elevated. Immunohistochemical staining for dystrophin was restricted to suspected revertant (characteristics of immaturity) fibers. Histologically, skeletal myofiber degeneration, endomysial fibrosis, and mineralization were present. Following euthanasia, necropsy revealed hypertrophy of the diaphragm and cardiac muscle fibrosis. This case of muscular dystrophy represents a slowly progressive form with organ agenesis.
Baltzer
Wendy Irene
WI
Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA.
Calise
David V
DV
Levine
Jonathan M
JM
Shelton
G D
GD
Edwards
John F
JF
Steiner
Joerg M
JM
D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D016189:Dystrophin / Q000172:deficiency*; D004576:Electromyography / Q000662:veterinary; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D009137:Muscular Dystrophy, Animal / Q000175:diagnosis* / Q000473:pathology
D016189:Dystrophin