title: Non-Latin European descent could be a requirement for association of NTDs and MTHFR variant 677C > T: a meta-analysis.
abstract: There are several studies that have found a positive association between neural tube defects (NTDs) and the common mutation 677C > T of 5,10-methylenetetrahydrofolate reductase (MTHFR), and others that have not found such an association. We updated the meta-analyses of the published data about NTDs and MTHFR 677C > T variant from January 1994 to October 2005 identifying 170 potentially relevant studies. After applying pertinent exclusion criteria, 37 different populations from 32 studies were included in the meta-analysis, with a total of 3,530 cases and 6,296 controls. Further we stratified the data according to geographical region and ethnicity, and produced two separated meta-analyses for non-Latin European and Latin European descent populations. The general (odds ratio 1.41; 95% confidence interval 1.24-1.59), and the non-Latin European meta-analyses (1.62; 1.38-1.90) indicate an association of TT genotype and NTDs; no association was demonstrated for Latin European populations (1.16; 0.95-1.43). The examination of non-Latin European studies revealed that the association of TT genotype with NTD has only been proven for Irish populations, both by case-control studies, and by family-based tests, such as the allele transmission disequilibrium test (TDT).
authors.affiliation: Estudo Colaborativo Latino Americano de Malformações Congênitas: ECLAMC at Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Márcia R
authors.initials: MR
authors.lastname: Amorim
authors.forename: Marcelo A C
authors.initials: MA
authors.lastname: Lima
authors.forename: Eduardo E
authors.initials: EE
authors.lastname: Castilla
authors.forename: Iêda M
authors.initials: IM
authors.lastname: Orioli
mesh_terms: D005060:Europe / Q000208:ethnology; D014644:Genetic Variation; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009436:Neural Tube Defects / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044469:Racial Groups
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)