Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations.
Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.
Spierings
Eric
E
Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. eric.spierings@lumc.nl
Hendriks
Matthijs
M
Absi
Léna
L
Canossi
Angelica
A
Chhaya
Sonal
S
Crowley
John
J
Dolstra
Harry
H
Eliaou
Jean-François
JF
Ellis
Tom
T
Enczmann
Jürgen
J
Fasano
Maria E
ME
Gervais
Thibaut
T
Gorodezky
Clara
C
Kircher
Brigitte
B
Laurin
David
D
Leffell
Mary S
MS
Loiseau
Pascale
P
Malkki
Mari
M
Markiewicz
Miroslaw
M
Martinetti
Miryam
M
Maruya
Etsuko
E
Mehra
Narinder
N
Oguz
Fatma
F
Oudshoorn
Machteld
M
Pereira
Noemi
N
Rani
Rajni
R
Sergeant
Ruhena
R
Thomson
Jackie
J
Tran
Thuong Hien
TH
Turpeinen
Hannu
H
Yang
Kuo-Liang
KL
Zunec
Renata
R
Carrington
Mary
M
de Knijff
Peter
P
Goulmy
Els
E
D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D016130:Immunophenotyping; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D044469:Racial Groups / Q000235:genetics*
D015778:Minor Histocompatibility Antigens