title: N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors.
abstract: A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo gamma-secretase activity.
authors.affiliation: Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. parkerm@BMS.com
authors.forename: Michael F
authors.initials: MF
authors.lastname: Parker
authors.forename: Donna M
authors.initials: DM
authors.lastname: Barten
authors.forename: Carl P
authors.initials: CP
authors.lastname: Bergstrom
authors.forename: Joanne J
authors.initials: JJ
authors.lastname: Bronson
authors.forename: Jason A
authors.initials: JA
authors.lastname: Corsa
authors.forename: Milind S
authors.initials: MS
authors.lastname: Deshpande
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Felsenstein
authors.forename: Valerie L
authors.initials: VL
authors.lastname: Guss
authors.forename: Steven B
authors.initials: SB
authors.lastname: Hansel
authors.forename: Graham
authors.initials: G
authors.lastname: Johnson
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Keavy
authors.forename: Wai Y
authors.initials: WY
authors.lastname: Lau
authors.forename: Jeremy
authors.initials: J
authors.lastname: Mock
authors.forename: C V C
authors.initials: CV
authors.lastname: Prasad
authors.forename: Craig T
authors.initials: CT
authors.lastname: Polson
authors.forename: Charles P
authors.initials: CP
authors.lastname: Sloan
authors.forename: David W
authors.initials: DW
authors.lastname: Smith
authors.forename: Owen B
authors.initials: OB
authors.lastname: Wallace
authors.forename: Henry H
authors.initials: HH
authors.lastname: Wang
authors.forename: Andrew
authors.initials: A
authors.lastname: Williams
authors.forename: Ming
authors.initials: M
authors.lastname: Zheng
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D015394:Molecular Structure; D011485:Protein Binding; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D016229:Amyloid beta-Peptides; D013449:Sulfonamides; D053829:Amyloid Precursor Protein Secretases