title: Treatment of menorrhagia.
abstract: Menorrhagia is defined as excessive uterine bleeding occurring at regular intervals or prolonged uterine bleeding lasting more than seven days. The classic definition of menorrhagia (i.e., greater than 80 mL of blood loss per cycle) is rarely used clinically. Women describe the loss or reduction of daily activities as more important than the actual volume of bleeding. Routine testing of all women with menorrhagia for inherited coagulation disorders is unnecessary. Saline infusion sonohysteroscopy detects intracavitary abnormalities such as endometrial polyps or uterine leiomyoma and is less expensive and invasive than hysteroscopy. Endometrial biopsy is effective for diagnosing precancerous lesions and adenocarcinoma but not for intracavitary lesions. Except for continuous progestin, medical therapies are limited. The levonorgestrel-releasing intrauterine device is an effective therapy for women who want to preserve fertility and avoid surgery. Surgical therapies include endometrial ablation methods that preserve the uterus; and hysterectomy, which results in high satisfaction rates but with potential surgical morbidity. Overall, hysterectomy and endometrial ablation result in the greatest satisfaction rates if future childbearing is not desired. Treatment of menorrhagia results in substantial improvement in quality of life.
authors.affiliation: University of Michigan Medical Center, Ann Arbor, Michigan, USA. bapgar@umich.edu
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Apgar
authors.forename: Amanda H
authors.initials: AH
authors.lastname: Kaufman
authors.forename: Uche
authors.initials: U
authors.lastname: George-Nwogu
authors.forename: Anne
authors.initials: A
authors.lastname: Kittendorf
mesh_terms: D000328:Adult; D001706:Biopsy; D017115:Catheter Ablation; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D053685:Laser Therapy; D007889:Leiomyoma / Q000175:diagnosis / Q000601:surgery; D008595:Menorrhagia / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D008598:Menstruation / Q000502:physiology; D011372:Progestins / Q000008:administration & dosage; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000601:surgery
chemical_list: D011372:Progestins