[Detection of plasma level of placental growth factor from patients with coronary artery disease].
OBJECTIVE
To investigate the plasma placental growth factor (P1GF) level of patients with coronary artery disease (CAD), and the correlation between plasma P1GF level and coronary lesion severity.


METHODS
The study population consisted of 48 patients with CAD (proved by angiography, CAD group) and 28 normal controls (control group). Plasma P1GF was determined by an enzyme linked immunosorbent assay (ELISA). The lesion severity of coronary artery was assessed by Gensini coronary scoring system, the correlation between plasma P1GF level and coronary lesion severity was evaluated.


RESULTS
The plasma PIGF level in CAD group was significantly higher than that in the control group C(9. 16+/-4. 09) ng/L vs (3. 64+/-1. 90) ng/L, P< 0. 01). A significant positive correlation was found between coronary lesion severity score and plasma P1GF level (r=0. 78, P<0. 01).


CONCLUSIONS
The detection of plasma PIGF may be helpful to the early diagnosis of CAD and the evaluation of coronary lesion severity.
You
Gui-ying
GY
Laboratory of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhu
Ye
Y
Yu
Jian-ying
JY
Liu
Xiao-jing
XJ
D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000097:blood*
C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor