Histamine H4 receptor expression is elevated in human nasal polyp tissue.
Altered histamine metabolism is thought to be involved in the pathomechanism of nasal polyposis characterized by local eosinophil infiltration. The present study was performed to determine whether histamine receptors play a role in the effect of histamine in nasal polyp tissue. The findings suggest that the expression of H1 and H4 receptors is elevated in polyp tissue (p=0.045; p<0.001), while the level of H2 and H3 receptors is not increased significantly. The elevation of H1 and H4 receptors' expression may indicate that the histamine related mechanisms are preferentially mediated through H1 and H4 histamine receptors in the polyp tissue. Simultaneously with increased H4 receptor expression, the concentration of eosinophil cationic protein (ECP) was increased significantly in polyp tissue (p=0.002). One may speculate that the H4 receptor mediated histamine effects have a role in eosinophil accumulation and activation in inflammatory diseases of the nasal and paranasal sinus mucosa, such as nasal polyposis.
Jókúti
Adrienn
A
Department of Otorhinolaryngology - Bajcsy-Zsilinszky Hospital, and Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary. jokutia@yahoo.com
Hellinger
Eva
E
Hellinger
Andrea
A
Darvas
Zsuzsa
Z
Falus
András
A
Thurmond
Robin L
RL
Hirschberg
Andor
A
D047150:Eosinophil Cationic Protein / Q000378:metabolism*; D004804:Eosinophils / Q000378:metabolism*; D006632:Histamine / Q000378:metabolism; D006801:Humans; D009298:Nasal Polyps / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D011968:Receptors, Histamine / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism; D000074040:Receptors, Histamine H4
C418607:HRH4 protein, human; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D000074040:Receptors, Histamine H4; D006632:Histamine; D047150:Eosinophil Cationic Protein; C479220:RNASE3 protein, human