title: Stroke after cardiac surgery in a patient with Smith-Magenis syndrome.
abstract: Patients with Smith-Magenis syndrome have a high incidence of congenital heart disease that requires open-heart surgery. These patients may have gene deletions that affect cholesterol homeostasis, although no previous association has been made with premature atherosclerosis. Herein, we report a case of such a patient, who experienced a stroke after cardiac surgery because of what we believe to be premature intracerebral atherosclerosis.
authors.affiliation: Division of Cardiothoracic Surgery, Brown University and Rhode Island Hospital, Providence, Rhode Island 02903, USA. calyas@hotmail.com
authors.forename: Alyas P
authors.initials: AP
authors.lastname: Chaudhry
authors.forename: Carl
authors.initials: C
authors.lastname: Schwartz
authors.forename: Arun K
authors.initials: AK
authors.lastname: Singh
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006330:Heart Defects, Congenital / Q000235:genetics / Q000601:surgery*; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D012086:Reoperation; D012307:Risk Factors; D020521:Stroke / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D013577:Syndrome; D016896:Treatment Outcome