Oral lipid-based formulations.
Poor drug solubility remains a significant and frequently encountered problem for pharmaceutical scientists. The ability of lipid-based formulations to facilitate gastrointestinal absorption of many poorly soluble drug candidates has been thoroughly documented in the published literature. However, a considerable gap exists between our knowledge of this technology and the know-how required for its application. This commentary provides a comprehensive summary of the development, characterization, and utilization of oral lipid-based formulations, from both physicochemical and biopharmaceutical perspectives. The characteristics of currently available lipid excipients are reviewed in context of their application to the basic lipid-based formulation modalities. The fundamental concepts of in vitro and in vivo evaluation of lipid-based formulations are summarized followed by a forward-looking summary of unrealized opportunities and potential limitations to more widespread use of this technology.
Hauss
David J
DJ
Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Route 206 and Province Line Road, Princeton, New Jersey 08543-4000, USA. david.hauss@bms.com
D000284:Administration, Oral; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D016503:Drug Delivery Systems; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D009821:Oils / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D012997:Solvents; D013501:Surface-Active Agents / Q000737:chemistry
D005079:Excipients; D008055:Lipids; D009821:Oils; D004364:Pharmaceutical Preparations; D012997:Solvents; D013501:Surface-Active Agents