Early life stress and novelty seeking behavior in adolescent monkeys.
Recent evidence suggests that early exposure to mild stress promotes the development of novelty seeking behavior. Here we test this hypothesis in squirrel monkeys and investigate whether novelty seeking behavior is associated with differences in cerebrospinal fluid (CSF) levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA), the dopamine metabolite homovanillic acid (HVA), the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), and the neuropeptide corticotrophin-releasing factor (CRF). Monkeys were randomized early in life to either mild intermittent stress (IS) or no stress (NS) conditions, and subsequently presented with opportunities to interact with a familiar or novel object in a test box that was connected to each monkey's home cage. To further minimize the potentially stressful nature of the test situation, monkeys were acclimated to the test procedures prior to study initiation. Post-test plasma levels of cortisol in IS and NS monkeys did not differ significantly from baseline levels measured in undisturbed conditions. During testing, more IS than NS monkeys voluntarily left the home cage, and IS monkeys spent more time in the test box compared to NS monkeys. More IS than NS monkeys engaged in object exploration in the test box, and IS monkeys preferred to interact with the novel vs. familiar object. Novelty seeking was not associated with differences in 5HIAA, HVA, MHPG, or CRF, but correlated with differences in object exploration observed in a different test situation at an earlier age. These trait-like differences in novelty seeking appear to reflect mild early stress-induced adaptations that enhance curiosity and resilience.
Parker
Karen J
KJ
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Road, MSLS Room P104, Mail Code 5485, Stanford, CA 94305-5485, USA. kjparker@stanford.edu
Rainwater
Kimberly L
KL
Buckmaster
Christine L
CL
Schatzberg
Alan F
AF
Lindley
Steven E
SE
Lyons
David M
DM
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid; D003627:Data Interpretation, Statistical; D005106:Exploratory Behavior / Q000502:physiology*; D006719:Homovanillic Acid / Q000097:blood; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007206:Individuality; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D012453:Saimiri; D013315:Stress, Psychological / Q000523:psychology*
D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D003346:Corticotropin-Releasing Hormone; D006719:Homovanillic Acid