Caudate nucleus hypointensity in the elderly is associated with markers of neurodegeneration on MRI.
In this study we investigated patterns of hypointense basal ganglia on T2*-weighted magnetic resonance imaging (MRI) in 413 non-demented elderly (range: 70-82 years, mean 77 years; male/female: 177/239). In addition, we assessed associations between these patterns and age-related changes in the brain. Three patterns were noted: hypointensity limited to the globus pallidus (group I; n=30; 7%), hypointensity of both globus pallidus and putamen (group II; n=272; 66%), and hypointensity of globus pallidus, putamen and caudate nucleus (group III; n=111; 27%). Group III demonstrated a higher volume of white matter hyperintensities, more atrophy, decreased whole brain magnetization transfer ratios and increased T2-values compared to groups I and II. No differences were observed between groups I and II. From this study we conclude that hypointensity of the caudate nucleus is associated with a higher load of age-related cerebral changes. These data suggest that hypointensity of the caudate nucleus could be a new biomarker of age-related changes in the brain.
van Es
Adriaan C G M
AC
Department of Radiology, C2-S, Leiden University Medical Center, RC Leiden, The Netherlands. A.C.G.M.van Es@LUMC.nl
van der Grond
Jeroen
J
de Craen
Anton J M
AJ
Admiraal-Behloul
Faiza
F
Blauw
Gerard J
GJ
van Buchem
Mark A
MA
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D002421:Caudate Nucleus / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019636:Neurodegenerative Diseases / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity