Bioactive peroxides as potential therapeutic agents.
Present review describes research on more than 280 natural anticancer agents isolated from terrestrial and marine sources and synthetic biologically active peroxides. Intensive searches for new classes of pharmacologically potent agents produced by terrestrial and marine organisms have resulted in the discovery of dozens of compounds possessing high cytotoxic, antibacterial, antimalarial, and other activities as an important source of leads for drug discovery.
Dembitsky
Valery M
VM
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University of Jerusalem, Ein Kerem Campus, P.O. Box 12065, Jerusalem 91120, Israel. dvalery@cc.huji.ac.il
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010545:Peroxides / Q000494:pharmacology / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D010545:Peroxides