title: Dysplasia and cancer in inflammatory bowel disease 10 years after diagnosis: results of a population-based European collaborative follow-up study.
abstract: OBJECTIVE
  To determine dysplasia and cancer in the 1991-2004 European Collaborative Inflammatory Bowel Disease (EC-IBD) Study Group cohort.
  
  
  METHODS
  A patient questionnaire and a physician per patient form were completed for each of the 1,141 inflammatory bowel disease patients (776 ulcerative colitis/365 Crohn's disease) from 9 centers (7 countries) derived from the EC-IBD cohort. Rates of detection of intestinal cancer and dysplasia as well as extra-intestinal neoplasms were computed.
  
  
  RESULTS
  Patient follow-up time was 10.3 +/- 0.8 (range 9.4-11) years. The mean age of the whole group of IBD patients was 37.8 +/- 11.3 (range 16-76) years. Thirty-eight patients (3.3%; 26 with ulcerative colitis/12 with Crohn's disease, 21 males/17 females, aged 61.3 +/- 13.4, range 33-77 years), were diagnosed with 42 cancers. Cancers occurred 5.4 +/- 3.3 (range 0-11) years after inflammatory bowel disease diagnosis. Colorectal cancer was diagnosed in 8 (1 Crohn's disease and 7 ulcerative colitis patients--0.3 and 0.9% of the Crohn's disease and ulcerative colitis cohort, respectively) of 38 patients and 30 cancers were extra-intestinal. Four of 38 patients (10.5%) were diagnosed as having 2 cancers and they were younger compared to patients with one cancer (p = 0.0008). There was a trend for a higher prevalence of intestinal cancer in the northern centers (0.9%) compared to southern centers (0.3%, p = NS). Southern centers had more cases of extra-intestinal cancer compared to northern centers (2 vs. 3.8%, p = 0.08). Ten patients (0.9%; 8 with ulcerative colitis/2 with Crohn's disease, 8 males, aged 62.3 +/- 14.1 years) had colorectal dysplasia.
  
  
  CONCLUSIONS
  In the first decade of the EC-IBD Study Group cohort follow-up study, the prevalence of cancer was as expected with most patients having a single neoplasm and an extra-intestinal neoplasm. In northern centers there was a trend for more intestinal cancers, while in southern centers there was a trend for more extra-intestinal cancers compared to northern centers.
authors.affiliation: Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece.
authors.forename: K H
authors.initials: KH
authors.lastname: Katsanos
authors.forename: S
authors.initials: S
authors.lastname: Vermeire
authors.forename: D K
authors.initials: DK
authors.lastname: Christodoulou
authors.forename: L
authors.initials: L
authors.lastname: Riis
authors.forename: F
authors.initials: F
authors.lastname: Wolters
authors.forename: S
authors.initials: S
authors.lastname: Odes
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authors.initials: J
authors.lastname: Freitas
authors.forename: Ole
authors.initials: O
authors.lastname: Hoie
authors.forename: Marina
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authors.lastname: Beltrami
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authors.lastname: Fornaciari
authors.forename: J
authors.initials: J
authors.lastname: Clofent
authors.forename: P
authors.initials: P
authors.lastname: Bodini
authors.forename: M
authors.initials: M
authors.lastname: Vatn
authors.forename: Paula Borralho
authors.initials: PB
authors.lastname: Nunes
authors.forename: B
authors.initials: B
authors.lastname: Moum
authors.forename: P
authors.initials: P
authors.lastname: Munkholm
authors.forename: C
authors.initials: C
authors.lastname: Limonard
authors.forename: R
authors.initials: R
authors.lastname: Stockbrugger
authors.forename: P
authors.initials: P
authors.lastname: Rutgeerts
authors.forename: E V
authors.initials: EV
authors.lastname: Tsianos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D016009:Chi-Square Distribution; D005060:Europe / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D007414:Intestinal Neoplasms / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D011795:Surveys and Questionnaires