Development of pH sensitive polyacrylamide grafted pectin hydrogel for controlled drug delivery system.
In the present study an attempt was made to graft polyacrylamide on pectin. The grafted polymer was characterized by FTIR spectroscopy, differential scanning calorimetry and X-ray diffraction. Rheological property of pectin solution was compared with the product solution. The grafted polymer was cross-linked with varying amount of glutaraldehyde. The swelling properties of the cross-linked product were also studied. The salicylic acid, an antipyretic drug, was incorporated in the cross-linked gel as a model drug and the drug release studies were done in a modified Franz's diffusion cell. The effect of cross-linking density on the release property of salicylic acid was studied through the cross-linked product. The product showed better film forming property and gelling property than pectin. The comparative rheological properties of pectin and grafted copolymer indicated change in the property of the product. FTIR studies indicated incorporation of amide group. Differential scanning calorimetry and XRD suggested formation of a new polymer. Swelling study indicated pH dependent swelling of the cross-linked hydrogel. Salicylic acid release indicated pH dependent release from the hydrogel.
Sutar
Prashant B
PB
Materials Science Centre, Indian Institute of Technology, Kharagpur, 721302, India.
Mishra
Rakesh K
RK
Pal
Kunal
K
Banthia
Ajit K
AK
D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D002152:Calorimetry, Differential Scanning / Q000379:methods; D003432:Cross-Linking Reagents / Q000494:pharmacology; D016503:Drug Delivery Systems; D005976:Glutaral / Q000494:pharmacology; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D051379:Mice; D010368:Pectins / Q000737:chemistry*; D051381:Rats; D020156:Salicylic Acid / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D014961:X-Ray Diffraction / Q000379:methods; D000099166:Polyacrylamides
D000180:Acrylic Resins; D003432:Cross-Linking Reagents; D005976:Glutaral; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010368:Pectins; D020156:Salicylic Acid; D000099166:Polyacrylamides