title: Decrease in activity of the serotoninergic system during mutagenesis.
abstract: We studied changes in the content of serotonin-modulated anticonsolidation protein in the liver of goldfishes and gobies caused by oil and industrial pollution. The concentration of serotonin-modulated anticonsolidation protein in fish liver increased after short-term exposure to oil-contaminated water (100 mg/liter), but decreased under long-term effect of industrial wastes. We hypothesize that serotonin plays a role in antimutagenic protection of the organism and maintains the differentiated state of mature cells.
authors.affiliation: A. I. Karaev Institute of Physiology, Azerbaijani Academy of Sciences, Baku. arifm@iphysiol.azeri.com
authors.forename: A A
authors.initials: AA
authors.lastname: Mekhtiev
authors.forename: A A
authors.initials: AA
authors.lastname: Gaisina
authors.forename: G M
authors.initials: GM
authors.lastname: Palatnikov
authors.forename: R Yu
authors.initials: RY
authors.lastname: Kasimov
mesh_terms: D000818:Animals; D006054:Goldfish / Q000235:genetics* / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D016296:Mutagenesis; D010578:Petroleum / Q000633:toxicity*; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D010578:Petroleum; D014874:Water Pollutants, Chemical; D012701:Serotonin