Ruptured mycotic abdominal aortic aneurysm secondary to Mycobacterium bovis after intravesical treatment with bacillus Calmette-Guérin.
Bacillus Calmette-Guérin (BCG) is a live attenuated strain of Mycobacterium bovis that has proven effective in the treatment of early-stage bladder cancer. Although intravesical therapy with BCG is generally considered safe, serious complications including hematuria, granulomatous pneumonitis, hepatitis, and life-threatening BCG sepsis are well known. BCG-related vascular infections are rarely reported. We present a case of a ruptured abdominal aortic aneurysm secondary to M bovis infection 2 years after intravesical instillation of BCG and review the related literature.
Harding
Gregory E J
GE
Division of Vascular Surgery, London Health Sciences Centre and University of Western Ontario, 800 Commissioners Road E., London, Ontario, Canada.
Lawlor
D Kirk
DK
D000283:Administration, Intravesical; D000369:Aged, 80 and over; D000785:Aneurysm, Infected / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000627:therapeutic use; D017544:Aortic Aneurysm, Abdominal / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D001019:Aortic Rupture / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D002295:Carcinoma, Transitional Cell / Q000628:therapy*; D006801:Humans; D008297:Male; D009163:Mycobacterium bovis / Q000302:isolation & purification*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014381:Tuberculosis, Cardiovascular / Q000150:complications / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D001749:Urinary Bladder Neoplasms / Q000628:therapy*; D014613:Vaccines, Attenuated / Q000009:adverse effects; D014656:Vascular Surgical Procedures
D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D001500:BCG Vaccine; D014613:Vaccines, Attenuated