title: Intravenous maternal hydration in third trimester oligohydramnios: effect on amniotic fluid volume.
abstract: OBJECTIVE
  To determine the affect of acute intravenous maternal hydration on amniotic fluid volume in patients with third trimester oligohydramnios.
  
  
  METHODS
  Quasi experimental study.
  
  
  METHODS
  Department of Obstetrics and Gynaecology Unit III, Sir Ganga Ram Hospital, Lahore, from May 2001 to April 2002.
  
  
  METHODS
  Twenty-five women with third trimester oligohydramnios (AFI < or = 5.0 cm) and 25 controls with normal amniotic fluid volume (AFI 8-24 cm) were prospectively recruited for this study. Study inclusion criteria were, singleton pregnancy, well-established gestational age, intact membranes, absence of maternal complication (anemia, cardiac disease, renal disease, pre-eclampsia, hypertension, or diabetes); absence of fetal structural malformation and/or distress. Maternal urinary specific gravity and amniotic fluid index were determined before and after intravenous hydration by infusing 2 liters of 5% dextrose water in 2 hours and recorded on printed proformas. Sample independent 't' test was used to compare the mean AFI and urine specific gravity before and after treatment, and the posttreatment AFI--pre-treatment AFI ( delta AFI).
  
  
  RESULTS
  Maternal hydration increased amniotic fluid volume (AFV) in women with oligohydramnios (mean change in amniotic fluid index 4.5 cm, 95% confidence interval 4.02 to 5.06; p-value<0.01); as well as in women with normal amniotic fluid volume (mean change in amniotic fluid index 2.7 cm, 95% confidence interval 2.23 to 3.21; p-value<0.01). The percentage increase in mean AFI was 58.6% in the oligohydramnios group, which was significantly greater (p<0.05) than the percentage increase of 28.4% in control group. Maternal hydration was associated with decrease in urinary specific gravity in both groups.
  
  
  CONCLUSIONS
  Under the conditions of this study, maternal (intravenous) hydration increased the AFV in women with oligohydramnios as well as in those with normal AFV and may be beneficial in the management of oligohydramnios.
authors.affiliation: Ministry of Population Welfare, Sir Gana Ram Hospital, Lahore, Pakistan. umber2001@hotmail.com
authors.forename: Aneela
authors.initials: A
authors.lastname: Umber
authors.forename: M Arshad
authors.initials: MA
authors.lastname: Chohan
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000502:physiology*; D016001:Confidence Intervals; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007038:Hypotonic Solutions / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D016104:Oligohydramnios / Q000503:physiopathology / Q000628:therapy*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D007038:Hypotonic Solutions