title: Pin-track infection in HIV-positive and HIV-negative patients with open fractures treated by external fixation: a prospective, blinded, case-controlled study.
abstract: Patients infected with HIV presenting with an open fracture of a long bone are difficult to manage. There is an unacceptably high rate of post-operative infection after internal fixation. There are no published data on the use of external fixation in such patients. We compared the rates of pin-track infection in HIV-positive and HIV-negative patients presenting with an open fracture. There were 47 patients with 50 external fixators, 13 of whom were HIV-positive (15 fixators). There were significantly more pin-track infections requiring pharmaceutical or surgical intervention (Checketts grade 2 or greater) in the HIV-positive group (t-test, p = 0.001). The overall rate of severe pin-track infection in the HIV-positive patients requiring removal of the external-fixator pins was 7%. This contrasts with other published data which have shown higher rates of wound infection if open fractures are treated by internal fixation. We recommend the use of external fixation for the treatment of open fractures in HIV-positive patients.
authors.affiliation: Beit Trust, CURE International Hospital, Blantyre, Malawi.
authors.forename: A R
authors.initials: AR
authors.lastname: Norrish
authors.forename: C P
authors.initials: CP
authors.lastname: Lewis
authors.forename: W J
authors.initials: WJ
authors.lastname: Harrison
mesh_terms: D000328:Adult; D004812:Epidemiologic Methods; D016267:External Fixators / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D005597:Fractures, Open / Q000601:surgery*; D015658:HIV Infections / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections