Compression and reflection of visually evoked cortical waves.
Neuronal interactions between primary and secondary visual cortical areas are important for visual processing, but the spatiotemporal patterns of the interaction are not well understood. We used voltage-sensitive dye imaging to visualize neuronal activity in rat visual cortex and found visually evoked waves propagating from V1 to other visual areas. A primary wave originated in the monocular area of V1 and was "compressed" when propagating to V2. A reflected wave initiated after compression and propagated backward into V1. The compression occurred at the V1/V2 border, and local GABAA inhibition is important for the compression. The compression/reflection pattern provides a two-phase modulation: V1 is first depolarized by the primary wave, and then V1 and V2 are simultaneously depolarized by the reflected and primary waves, respectively. The compression/reflection pattern only occurred for evoked waves and not for spontaneous waves, suggesting that it is organized by an internal mechanism associated with visual processing.
Xu
Weifeng
W
Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20057, USA. wuj@georgetown.edu
Huang
Xiaoying
X
Takagaki
Kentaroh
K
Wu
Jian-young
JY
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D003627:Data Interpretation, Statistical; D004562:Electrocardiography; D004594:Electrophysiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D018756:GABA Antagonists / Q000494:pharmacology; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D010775:Photic Stimulation; D051381:Rats; D020318:Rats, Long-Evans; D013003:Somatosensory Cortex / Q000502:physiology; D013239:Stereotyped Behavior / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology*
D018756:GABA Antagonists; D001640:Bicuculline