title: [The relation of peroxisome proliferator activated receptorbeta and Epithelial Ovarian Carcinoma].
abstract: OBJECTIVE
  To explore the possible relationship between expression of PPAR(pevoxisome prodiferator adivated receptor) beta and clinical pathological features of epithelial ovarian carcinoma (EOC).
  
  
  METHODS
  PPARbeta expressions in normal ovaries (n=10), ovarian bordline tumors (n=10), and ovarian serous cystadenocarcinomas (n=46) were investigated by immunohistochemistry and RT-PCR.
  
  
  RESULTS
  PPARbeta protein was expressed in normal ovaries and ovarian cancer. PPARbeta protein was found in cytoplasm of tumor cell. PPARbeta expression was 20% revealed in normal ovaries, 50% in bordline tumors 89.1% in serous cystadenocarcinomas(P<0.05), significantly higher than that in bordline tumors (P<0.05). PPARbeta expression was positively correlated with tumor stage, histological grade and lymphonode metastasis (P<0.05).
  
  
  CONCLUSIONS
  High expression of PPARbeta may be related with the differentiation and metastasis of epithelial ovarian carcinoma.
authors.affiliation: Department of Anatomy, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Jian-qing
authors.initials: JQ
authors.lastname: Hou
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Ju
authors.forename: Zhen-hai
authors.initials: ZH
authors.lastname: Yu
authors.forename: Zhi-wei
authors.initials: ZW
authors.lastname: Zhao
authors.forename: Shu
authors.initials: S
authors.lastname: Yang
authors.forename: Hui-jun
authors.initials: HJ
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D018284:Cystadenocarcinoma, Serous / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism*; D048068:PPAR-beta / Q000235:genetics* / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D048068:PPAR-beta