title: Botulinum toxin treatment for anal fissure.
abstract: OBJECTIVE
  To evaluate the effectiveness of Botulinum toxin injection in the treatment of anal fissure.
  
  
  METHODS
  38 patients (22 males, 16 females; mean age (SD) of 33.3 (8.3) years) who have presented to Surgical Outpatient Clinic at Al Ain Hospital, United Arab Emirates, with anal fissure in the period between June 2000 and September 2001 and treated with Botulinum toxin injection were retrospectively studied. They were followed up for at least 8 weeks to evaluate the effects of treatment.
  
  
  RESULTS
  Treatment with Botulinum toxin was effective in 89% of patients with chronic uncomplicated anal fissure. Two patients experienced minor incontinence in the form of a fecal soiling which disappeared later.
  
  
  CONCLUSIONS
  Botulinum toxin injection is an effective alternative for surgery for treatment of uncomplicated idiopathic anal fissure. Surgery should be offered to patients who do not improve with Botulinum toxin injection and to those with complicated anal fissure.
authors.affiliation: Department of Surgery, Al-Ain Hospital, Al-Ain, United Arab Emirates.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Radwan
authors.forename: Khalil
authors.initials: K
authors.lastname: Ramdan
authors.forename: Ismail
authors.initials: I
authors.lastname: Abu-Azab
authors.forename: Fikri M
authors.initials: FM
authors.lastname: Abu-Zidan
mesh_terms: D000328:Adult; D001340:Autonomic Nerve Block / Q000009:adverse effects; D019274:Botulinum Toxins, Type A / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005401:Fissure in Ano / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009465:Neuromuscular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D012449:Safety; D014945:Wound Healing
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A