Spectrophotometric simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form.
A new simple, economical, rapid, precise and accurate method for simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form has been developed. The method is based on ratio spectra derivative spectrophotometry. The amplitudes in the first derivative of the corresponding ratio spectra at 231nm (minima) and 260nm were selected to determine rabeprazole sodium and itopride hydrochloride, respectively. The method was validated with respect to linearity, precision and accuracy.
Sabnis
Shweta S
SS
Department of Pharmaceutical Analysis, A.I.S.S.M.S. College of Pharmacy, Kennedy Road, Near R.T.O., Pune 411 001, Maharashtra, India.
Dhavale
Nilesh D
ND
Jadhav
Vijay Y
VY
Gandhi
Santosh V
SV
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000032:analysis*; D001549:Benzamides / Q000032:analysis*; D001593:Benzyl Compounds / Q000032:analysis*; D002214:Capsules / Q000737:chemistry*; D064750:Rabeprazole; D012015:Reference Standards; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001549:Benzamides; D001593:Benzyl Compounds; D002214:Capsules; D012996:Solutions; D064750:Rabeprazole; C102254:itopride