title: Changes in cognitive dysfunction in children and adolescents with obsessive-compulsive disorder after treatment.
abstract: The majority of follow-up studies show stability of deficits after treatment in adults with obsessive-compulsive disorder (OCD), regardless of improvement in symptomatology, and this suggests a possibly chronic dysfunction of the dorsolateral-striatal circuit. To our knowledge, this is the first study to explore the evolution of cognitive dysfunction in children and adolescents with OCD after treatment. A neuropsychological battery designed for this study was administered to 29 OCD patients aged between 7 and 18 years before and after 6 months of naturalistic treatment, and to 22 healthy subjects of similar age, sex and intellectual level. In the first assessment, the OCD group performed worse on some tests of memory, speed of information processing and executive functions, this being similar to the cognitive dysfunction described in adult patients. After treatment the cognitive profile of the OCD group was normalized, and many of the significant differences present in the first assessment disappeared. Children and adolescents did not show the stability in cognitive dysfunction described in studies with adults. Six months of effective treatment normalized cognitive performance in young patients, who showed an important response to treatment.
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychology, Institute Clinic of Neurosciences, Hospital Clinic, C/Villarroel, 170, 08036 Barcelona, Spain. sandres@clinic.ub.es
authors.forename: Susana
authors.initials: S
authors.lastname: Andrés
authors.forename: Luisa
authors.initials: L
authors.lastname: Lázaro
authors.forename: Manel
authors.initials: M
authors.lastname: Salamero
authors.forename: Teresa
authors.initials: T
authors.lastname: Boget
authors.forename: Rafael
authors.initials: R
authors.lastname: Penadés
authors.forename: Josefina
authors.initials: J
authors.lastname: Castro-Fornieles
mesh_terms: D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D002997:Clomipramine / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D003376:Counseling / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000188:drug therapy / Q000628:therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D002997:Clomipramine; D017367:Selective Serotonin Reuptake Inhibitors