title: HLA-B51 gene and its expression in association with Behçet's Disease in Denizli Province of Turkey.
abstract: Behçet's Disease (BD) is a multisystemic inflammatory disorder as a triad of symptoms including recurrent oral and genital aphthous ulceration, and uveitis with unknown pathogenesis. Many researchers have tried to investigate the association of HLA-B51 gene with the BD. We aimed to investigate the association of the HLA-B51 gene and its expression, also polymorphic structure by PCR, RT-PCR and sequence specific oligonucleotide primers and probes in BD patients (n: 35) and control group (n: 50). According to our results, we did not observe any association in between HLA-B51 gene, its polymorphism, expression and BD patients.
authors.affiliation: Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey. aatalay@pau.edu.tr
authors.forename: Ayfer
authors.initials: A
authors.lastname: Atalay
authors.forename: Sanem
authors.initials: S
authors.lastname: Yildiz-Demirtepe
authors.forename: Sinan
authors.initials: S
authors.lastname: Tatlipinar
authors.forename: Berna
authors.initials: B
authors.lastname: Sanli-Erdoğan
authors.forename: Veli
authors.initials: V
authors.lastname: Cobankara
authors.forename: Cem
authors.initials: C
authors.lastname: Yildirim
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Bağci
authors.forename: Erol Omer
authors.initials: EO
authors.lastname: Atalay
mesh_terms: D001528:Behcet Syndrome / Q000235:genetics* / Q000276:immunology*; D001665:Binding Sites; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology*; D059949:HLA-B51 Antigen; D006262:Health; D006801:Humans; D008297:Male; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D014421:Turkey; D001613:beta 2-Microglobulin / Q000235:genetics / Q000378:metabolism
chemical_list: D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D012333:RNA, Messenger; D011948:Receptors, Antigen, T-Cell; D001613:beta 2-Microglobulin; C490245:GEM protein, human; D020559:Monomeric GTP-Binding Proteins