Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro.
Bioactive glasses (BAGs) of different compositions have been studied for decades for clinical use and they have found many dental and orthopaedic applications. Particulate BAGs have also been shown to have antibacterial properties. This large-scale study shows that two bioactive glass powders (S53P4 and 13-93) and a sol-gel derived material (CaPSiO II) have an antibacterial effect on 17 clinically important anaerobic bacterial species. All the materials tested demonstrated growth inhibition, although the concentration and time needed for the effect varied depending on the BAG. Glass S53P4 had a strong growth-inhibitory effect on all pathogens tested. Glass 13-93 and sol-gel derived material CaPSiO II showed moderate antibacterial properties.
Leppäranta
Outi
O
Department of Medical Microbiology, University of Turku, Kiinamyllynkatu 13, Turku, Finland. oupale@utu.fi
Vaahtio
Minna
M
Peltola
Timo
T
Zhang
Di
D
Hupa
Leena
L
Hupa
Mikko
M
Ylänen
Heimo
H
Salonen
Jukka I
JI
Viljanen
Matti K
MK
Eerola
Erkki
E
D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001672:Biocompatible Materials; D005898:Glass; D013997:Time Factors
D000891:Anti-Infective Agents, Local; D001672:Biocompatible Materials