Midterm experience with the Jarvik 2000 axial flow left ventricular assist device.
OBJECTIVE
Rotary axial flow pumps have several potential advantages and disadvantages over pulsatile pumps. The Jarvik 2000 is distinctive in being intracardiac. We report our experience in 22 patients.


METHODS
The Jarvik 2000 was implanted in 15 men and 7 women. Mean age was 38.8 (range 23-59) years, preoperative diagnosis was dilated cardiomyopathy in 16, postpartum cardiomyopathy in 3, ischemic heart disease in 2, and chronic allograft failure in 1. Twenty-one patients were in New York Heart Association class IV, and 1 patient was in class III. Nineteen patients were on inotropic support, 6 were supported with an intra-aortic balloon pump, and 2 patients had been salvaged with a Centrimag (Levitronix) ventricular assist device. The median pulmonary vascular resistance was 3 Wood units; median pulmonary capillary wedge pressure was 26.6 mm Hg; and mean Cardiac Index was 1.5 L/min/m2.


RESULTS
There were 2 early deaths and 6 late deaths. The average postoperative ventilation time and Intensive Treatment Unit stay was 2.2 and 10 days, respectively. One patient required a right ventricular assist device for short-term support and another for medium-term support. Seven patients were bridged to transplant, 3 had myocardial recovery, and 4 are ongoing. Mean and total duration of support was 280.5 and 6172 days, respectively. Driveline failures were noted in 3, but there were no pump infections or failure.


CONCLUSIONS
The Jarvik 2000 provides satisfactory intermediate-term results as a bridge to transplant or recovery. It appears to be associated with a low rate of serious driveline or pump infections and technical failure. However, bleeding complications due to the required anticoagulation treatment frequently occurred.
Haj-Yahia
Saleem
S
Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton & Harefield Hospital, London, UK.
Birks
Emma J
EJ
Rogers
Paula
P
Bowles
Christopher
C
Hipkins
Mandy
M
George
Robert
R
Amrani
Mohammed
M
Petrou
Mario
M
Pepper
John
J
Dreyfus
Gilles
G
Khaghani
Asghar
A
D000328:Adult; D000714:Anastomosis, Surgical / Q000009:adverse effects; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D019544:Equipment Failure Analysis; D005260:Female; D006352:Heart Ventricles / Q000601:surgery*; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D011182:Postoperative Care; D019106:Postoperative Hemorrhage / Q000209:etiology; D011474:Prosthesis Design; D012189:Retrospective Studies; D018805:Sepsis / Q000209:etiology; D013530:Surgical Wound Infection / Q000209:etiology; D013927:Thrombosis / Q000209:etiology