title: Intra-arterial thrombolysis in a 2-year-old with cardioembolic stroke.
abstract: Recombinant tissue plasminogen activator, although the standard of care for the management of acute ischemic stroke in adults, is used infrequently in children. The authors describe the use of intra-arterial recombinant tissue plasminogen activator in a young child with embolic stroke. Thrombolysis restored flow to the affected middle cerebral artery and appeared to limit the extent of the infarction and the severity of the subsequent neurologic deficits.
authors.affiliation: Department of Pediatrics, University of Utah, Primary Children's Medical Center, Salt Lake City, Utah 84158, USA. susan.benedict@hsc.utah.edu
authors.forename: Susan L
authors.initials: SL
authors.lastname: Benedict
authors.forename: Oliver K
authors.initials: OK
authors.lastname: Ni
authors.forename: Peter
authors.initials: P
authors.lastname: Schloesser
authors.forename: Keith S
authors.initials: KS
authors.lastname: White
authors.forename: James F
authors.initials: JF
authors.lastname: Bale
mesh_terms: D002675:Child, Preschool; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D020244:Infarction, Middle Cerebral Artery; D007269:Injections, Intra-Arterial / Q000379:methods; D010960:Plasminogen Activators / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy
chemical_list: D005343:Fibrinolytic Agents; D010960:Plasminogen Activators