title: Association between microvessel density and histologic grade in renal cell carcinomas.
abstract: Angiogenesis seems to contribute to tumor growth and the development of metastases. There may be an association between the vascular density of individual tumors and their prognosis. In the present survey we studied 53 cases of renal cell carcinoma investigating possible relationship between histologic grade and microvessel density (MVD) measured by an image analysis system. According to our results MVD was significantly associated with the histologic grade, higher grades being accompanied with a higher MVD. Further studies are needed to investigate a possible connection of MVD with the prognostic role of grade in RCCs.
authors.affiliation: Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Athens, GR-157 73, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kavantzas
authors.forename: Helen
authors.initials: H
authors.lastname: Paraskevakou
authors.forename: Sofia
authors.initials: S
authors.lastname: Tseleni-Balafouta
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Aroni
authors.forename: Pauline
authors.initials: P
authors.lastname: Athanassiades
authors.forename: George
authors.initials: G
authors.lastname: Agrogiannis
authors.forename: Efstratios
authors.initials: E
authors.lastname: Patsouris
mesh_terms: D001160:Arterioles / Q000473:pathology / Q000503:physiopathology*; D002196:Capillaries / Q000473:pathology / Q000503:physiopathology*; D002292:Carcinoma, Renal Cell / Q000098:blood supply* / Q000473:pathology; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D005169:Factor VIII / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007680:Kidney Neoplasms / Q000098:blood supply* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D011379:Prognosis; D014699:Venules / Q000473:pathology / Q000503:physiopathology*
chemical_list: D005169:Factor VIII