title: Recurrent pregnancy loss and thrombophilia.
abstract: In the last decades we found many data concerning the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL). Although first studies were focused only on the association between thrombophilia and RPL, subsequent studies underlined also a potential role of antithrombotic treatment to prevent vascular complication such as venous thromboembolism (VTE) during pregnancy. Now, emerging data seem to be available also on the role of active thromboprophylaxis with heparin and pregnancy outcome. This review will be focused on the recent knowledge between thrombophilia, hypercoagulable state, RPL, VTE and future perspectives.
authors.affiliation: Internal Medicine Division, Buonconsiglio Fatebenefratelli Hospital of Naples, Naples, Italy. pdimicco@libero.it
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Di Micco
authors.forename: Maristella
authors.initials: M
authors.lastname: D'uva
authors.forename: Ida
authors.initials: I
authors.lastname: Strina
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Placido
authors.forename: Rosanna
authors.initials: R
authors.lastname: Di Fiore
authors.forename: Sandro
authors.initials: S
authors.lastname: Quaranta
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Castaldo
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology* / Q000235:genetics; D016736:Antiphospholipid Syndrome / Q000175:diagnosis; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications / Q000235:genetics; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome; D019851:Thrombophilia / Q000150:complications* / Q000188:drug therapy* / Q000235:genetics; D054556:Venous Thromboembolism / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D006495:Heparin, Low-Molecular-Weight; D042965:Methylenetetrahydrofolate Reductase (NADPH2)