title: Statistically significant changes of antimüllerian hormone and inhibin levels during the physiologic menstrual cycle in reproductive age women.
abstract: OBJECTIVE
  To define the dynamics of antimüllerian hormone (AMH) and inhibins during the physiologic menstrual cycle.
  
  
  METHODS
  Longitudinal study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  36 young, healthy, normal weight Caucasian women without medication.
  
  
  METHODS
  Normal ovulatory menstrual cycles were evaluated by regular blood sampling taken every other day and periovulatory every day.
  
  
  METHODS
  Serum concentrations of AMH, inhibin A and B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, progesterone, and free testosterone were measured in all blood samples.
  
  
  RESULTS
  Median AMH levels are statistically significantly higher in the late follicular compared with ovulation or the early luteal phase. There are statistically significant correlations between both AMH and FSH, and AMH and free testosterone in all cycle phases. Inhibin A increases strongly in the late follicular phase and peaks at day LH + 4. Inhibin B shows a broad midfollicular and a sharp early luteal peak, the difference being statistically significant between day LH + 4 and the earlier time points and between day LH + 2 and day LH. Although there is a negative association between inhibin A or B and the body mass index (BMI), there is no correlation between AMH and the BMI.
  
  
  CONCLUSIONS
  Levels of AMH show a statistically significant change during the menstrual cycle and may influence the circulating gonadotropin and steroid hormone levels.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Berne, Berne, Switzerland. dorothea.wunder@insel.ch
authors.forename: Dorothea M
authors.initials: DM
authors.lastname: Wunder
authors.forename: Nick A
authors.initials: NA
authors.lastname: Bersinger
authors.forename: Mengistu
authors.initials: M
authors.lastname: Yared
authors.forename: Robert
authors.initials: R
authors.lastname: Kretschmer
authors.forename: Martin H
authors.initials: MH
authors.lastname: Birkhäuser
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015992:Body Mass Index; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007265:Inhibins / Q000097:blood*; D008137:Longitudinal Studies; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood*; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D012016:Reference Values; D012098:Reproduction; D013739:Testosterone / Q000097:blood; D013997:Time Factors
chemical_list: C422362:inhibin A; C422364:inhibin B; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D007265:Inhibins; D054304:Anti-Mullerian Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone