title: Nonfunctioning endocrine tumor arising from intracranial ectopic pancreas associated with congenital brain malformation.
abstract: METHODS
  We report a case of a nonfunctioning pancreatic endocrine tumor arising from intracranial ectopic pancreatic tissue.
  
  
  METHODS
  An 11-year-old girl was admitted to our hospital with a brain tumor. Hydrocephalus and brain malformation were apparent at birth. We first identified a mass-like lesion in the child's brain at age 4 months. We monitored the lesion yearly by magnetic resonance imaging (MRI) until she reached age 11 years. Gadolinium-enhanced MRI showed the lesion to be a tumor, which was resected.
  
  
  METHODS
  Examination of surgical specimens revealed a mature pancreatic tissue. We also identified monotonous neoplastic cells with round nuclei and positive immunoreactivity for synaptophysin, chromogranin A, and neurospecific enolase. However, these cells were negative for pancreatic endocrine markers. We diagnosed nonfunctioning pancreatic endocrine tumor arising from intracranial ectopic pancreatic tissue.
  
  
  CONCLUSIONS
  Migrating pancreatic elements may have induced brain malformation during embryonic development and subsequently become malignant.
authors.affiliation: Department of Neurosurgery, Fukuoka University Faculty of Medicine, 45-1, 7-chome, Nanakuma Jonan-ku, Fukuoka 814-0180, Japan. h-tsugu@fukuoka-u.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tsugu
authors.forename: Shinya
authors.initials: S
authors.lastname: Oshiro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Takeo
authors.initials: T
authors.lastname: Fukushima
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nabeshima
authors.forename: Shinji
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nomura
authors.forename: Sawa
authors.initials: S
authors.lastname: Yasumoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Takano
authors.forename: Hidetsuna
authors.initials: H
authors.lastname: Utsunomiya
mesh_terms: D001927:Brain Diseases / Q000473:pathology* / Q000601:surgery; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D002648:Child; D002828:Choristoma / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D009421:Nervous System Malformations / Q000473:pathology* / Q000601:surgery; D010179:Pancreas; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome