[Syntheses and biological activities of glycoconjugates].
This review describes the oligosaccharide syntheses and biological activities of glycosphingolipids, focusing especially on those found in invertebrates like millipedes, nematoda parasites, and cestoda parasites, and model compounds related to a major antigenic epitope against antibupleurum 2IIc/PG-1-IgG from antiulcer pectic polysaccharides. A novel and simple approach for the rational design of glycoclusters and glycodendrimers by coupling with a sugar unit and a cluster unit, was developed with beta-alanine derivatives used to construct the latter compounds.
Hada
Noriyasu
N
Division of Natural Medicines, Kyoritsu University of Pharmacy, Tokyo, Japan. hada-nr@kyoritsu-ph.ac.jp
D000818:Animals; D029972:Bupleurum / Q000737:chemistry; D015195:Drug Design; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry / Q000502:physiology; D006028:Glycosphingolipids; D007448:Invertebrates / Q000737:chemistry; D008968:Molecular Conformation; D009844:Oligosaccharides; D010368:Pectins / Q000276:immunology
D006001:Glycoconjugates; D006028:Glycosphingolipids; D009844:Oligosaccharides; C073829:Bupleuran 2IIc; D010368:Pectins