[New insights in atherosclerosis research: LOX-1, leading actor of cardiovascular diseases].
The OLR1 gene encodes a cell-surface endocytosis receptor (LOX-1) for oxidized low density lipoprotein (OxLDL). LDL is oxidized in vascular endothelial cells to a highly injurious product that results in endothelial cell injury, which is implicated in the development of atherosclerosis. Vascular endothelial cells also internalize and degrade oxLDL though the OLR1 receptor. This receptor is upregulated by ox-LDL itself and by angiotensin II, endothelin, cytokines, and shear stress, important factors of atherosclerosis. This receptor is upregulated in the arteries of hypertensive, dyslipidemic, and diabetic animals. Two independent studies have demonstrated genetic association between polymorphisms in the OLR1 gene and myocardial infarction. Based on genetic and functional studies we propose LOX-1 as a novel biomarker and target in cardiovascular disease diagnosis and prevention.
Novelli
G
G
Dipartimento di Biopatologia e Diagnostica per Immagini, Università di Roma Tor Vergata, Italia. novelli@med.uniroma2.it
Mango
R
R
Vecchione
L
L
Mariotti
E
E
Borgiani
P
P
Mehta
J L
JL
Romeo
F
F
D000594:Amino Acid Oxidoreductases / Q000235:genetics* / Q000502:physiology; D000818:Animals; D050197:Atherosclerosis / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics*; D006801:Humans
D000594:Amino Acid Oxidoreductases; C445313:LOXL1 protein, human