title: Pathologic findings and outcomes for octogenarians presenting with uterine malignancy.
abstract: OBJECTIVE
  We evaluated prognostic, demographic and outcome data for patients>80 years old with uterine cancer (UC).
  
  
  METHODS
  A retrospective review of clinical records was performed. Categorical data were compared using Fisher's exact test and Kaplan-Meier for survival data.
  
  
  RESULTS
  Sixty-five patients were identified with a mean age of 84 and BMI 27. Sixty-five percent of patients had medical co-morbidities. Forty-two (65%) were Stage I; 10 (15%) were Stage II; 8 (12%) were Stage III; and 5 (8%) were Stage IV. Stage I patients included those identified via hysterectomy with lymph nodes (LND) (30) or clinical impression (12). Comparing clinically Stage I UC to those with LND, the clinical group was older (86 vs. 83; p=0.01) and tended to have more medical co-morbidity (89% vs. 63%; p=0.14). Two-year overall survival (OS) among unstaged vs. staged patients was 62% vs. 77%; p=0.11. Among staged patients with Stage I UC, 21 (70%) met high intermediate risk (HIR) criteria per GOG 99 and 90% received no adjuvant therapy. Three patients (16%) recurred with 1 (5%) locoregional recurrence. Two-year OS is 77%.
  
  
  CONCLUSIONS
  Elderly patients with UC have features associated with extrauterine spread. Both clinically and surgically staged Stage I patients had excellent OS at 2 years despite no adjuvant therapy. Prevalent medical co-morbidities may impact survival more than recurrence risk. The 23% recurrence rate among HIR patients in GOG 99 was not observed in our data, suggesting that observation for elderly Stage I patients is acceptable.
authors.affiliation: University of Oklahoma Division of Gynecologic Oncology, 920 SL Young Blvd., Oklahoma City, OK 73103, USA. Kathleen-moore@ouhsc.edu
authors.forename: Kathleen N
authors.initials: KN
authors.lastname: Moore
authors.forename: Grainger S
authors.initials: GS
authors.lastname: Lanneau
authors.forename: Chad
authors.initials: C
authors.lastname: Smith
authors.forename: Marion
authors.initials: M
authors.lastname: Lanneau
authors.forename: Joan L
authors.initials: JL
authors.lastname: Walker
authors.forename: Michael A
authors.initials: MA
authors.lastname: Gold
authors.forename: D
authors.initials: D
authors.lastname: Scott McMeekin
mesh_terms: D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery