title: Acute myocardial infarction and underlying stenosis severity.
abstract: OBJECTIVE
  The objective of this study was to investigate the underlying stenosis severity of the culprit lesion in acute myocardial infarction.
  
  
  BACKGROUND
  It is widely believed that myocardial infarction often occurs in angiographically mild luminal stenosis. This, however, is in contradiction with experience from interventional practice in primary PCI.
  
  
  METHODS
  We performed quantitative coronary angiography (QCA) in 250 consecutive patients referred for acute percutaneous coronary intervention (PCI) because of acute myocardial infarction (AMI). Fundamental for analysis was that a realistic estimate of underlying luminal narrowing before the infarction could be made angiographically that QCA could be performed and that one of two criteria was met: (1) spontaneous reflow allowing assessment of the lumen proximal and distal to the culprit lesion, or (2) coronary artery closed at arrival but reflow after uncomplicated wiring allowing assessment of the lumen proximal and distal to the culprit lesion.
  
  
  RESULTS
  Of 250 consecutive patients (mean age 61.7 +/- 12.7 years, 48 women) referred for acute PCI, 156 patients (62%) fulfilled at least one of the above criteria for reliable QCA. In 151 of these patients (96%) the severity of the underlying stenosis was >50% and in 103 (66%) it was >70%. There were no differences in stenosis severity between the left anterior descending [LAD, (72 +/- 13)%, n = 57], left circumflex [Cx, (74 +/- 10)%, n = 20], and right coronary artery territory [RCA, (74 +/- 12)%, n = 76] (ANOVA, P = 0.76). There were no differences in stenosis severity between women [(73 +/- 13)%, n = 36] and men [(75 +/- 11)%, n = 120; P = 0.35].
  
  
  CONCLUSIONS
  In contrast to what is often believed, the majority of myocardial infarctions occurs in significant stenosis.
authors.affiliation: Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, University of Aarhus, Denmark.
authors.forename: Ole
authors.initials: O
authors.lastname: Frøbert
authors.forename: Marcel
authors.initials: M
authors.lastname: van't Veer
authors.forename: Wilbert
authors.initials: W
authors.lastname: Aarnoudse
authors.forename: Ulf
authors.initials: U
authors.lastname: Simonsen
authors.forename: Jacques J
authors.initials: JJ
authors.lastname: Koolen
authors.forename: Nico H J
authors.initials: NH
authors.lastname: Pijls
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003326:Coronary Circulation; D023921:Coronary Stenosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D015203:Reproducibility of Results; D012107:Research Design; D012720:Severity of Illness Index