title: Evening alcohol suppresses salivary melatonin in young adults.
abstract: The study objective was to determine the acute effects of a moderate evening dose of alcohol on salivary melatonin levels in humans with stable prior sleep-wake histories and in a controlled environment. Twenty-nine adults (nine males) ages 21 to 25 (M=22.6, SD=1.2) yrs adhered to a 10-day at-home stabilized sleep schedule followed by three in-lab adaptation, placebo, and alcohol (order counterbalanced) study nights. Alcohol (vodka: 0.54 g/kg for men and 0.49 g/kg for women) or placebo beverage was consumed over 30 min, ending 1 h before stabilized bedtime. At 140 and 190 min after alcohol administration, melatonin level was reduced by 15% and 19%, respectively, in comparison to placebo. The findings indicate that a moderate dose of alcohol in the evening suppressed melatonin in young adults.
authors.affiliation: E.P. Bradley Sleep and Chronobiology Laboratory, Providence, Rhode Island, USA. tracy.rupp@amedd.army.mil
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Rupp
authors.forename: Christine
authors.initials: C
authors.lastname: Acebo
authors.forename: Mary A
authors.initials: MA
authors.lastname: Carskadon
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000378:metabolism*; D001944:Breath Tests; D000431:Ethanol / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*; D012737:Sex Factors; D012890:Sleep / Q000502:physiology; D013997:Time Factors
chemical_list: D000431:Ethanol; D008550:Melatonin