[What's new in multiple sclerosis genetics?].
BACKGROUND
Multiple Sclerosis (MS) is a multifactorial disorder caused by the interaction of environmental factors with a genetic predisposition.


BACKGROUND
The chromosomal region comprising MHC contains one or several genes which contributes from 20 to 50 p. 100 to MS genetic predisposition. Other genes are unknown but are likely to have an individual contribution less than MHC.


CONCLUSIONS
Large DNA collections, high output genotyping facilities, a precise knowledge of the human genome and adequate statistical methods should allow the identification of MS predisposition genes.
Fontaine
B
B
Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS 546 and UMRS 535, Paris and Villejuif, France. bertrand.fontaine@psl.aphp.fr
Sémana
G
G
Clerget-Darpoux
F
F
D002877:Chromosomes, Human / Q000235:genetics / Q000502:physiology; D004247:DNA / Q000235:genetics; D004777:Environment; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D018995:Myosin Heavy Chains / Q000235:genetics
D004247:DNA; D018995:Myosin Heavy Chains