title: Antiarrhythmic induced electrical storm in Brugada syndrome: a case report.
abstract: Brugada syndrome (BS) may be "unmasked" by several pharmacological and/or physiological agents in an otherwise normal electrocardiogram. Once diagnosed the possibility of persistent ventricular tachycardia/fibrillation exists. Although this is treated with various antiarrhythmic agents, there remains a cohort of patients who fail to respond to conventional antiarrhythmic therapy therefore, amplifying the electrical storm. We report a case of a BS diagnosed via procainamide challenge, the resultant near fatal electrical storm aggravated by amiodarone and the eventual resolution with isoproterenol.
authors.affiliation: Division of Cardiology, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA. Sjoshi@chpnet.org
authors.forename: Sandeep
authors.initials: S
authors.lastname: Joshi
authors.forename: Farbod
authors.initials: F
authors.lastname: Raiszadeh
authors.forename: Walter
authors.initials: W
authors.lastname: Pierce
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Steinberg
mesh_terms: D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents; D053840:Brugada Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D017147:Defibrillators, Implantable; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000627:therapeutic use*; D008875:Middle Aged; D011342:Procainamide; D017180:Tachycardia, Ventricular / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D014665:Vasodilator Agents / Q000009:adverse effects*; D014693:Ventricular Fibrillation / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D000318:Adrenergic beta-Agonists; D000889:Anti-Arrhythmia Agents; D014665:Vasodilator Agents; D011342:Procainamide; D007545:Isoproterenol; D000638:Amiodarone