title: Neonatal jaundice and stool production in breast- or formula-fed term infants.
abstract: It has remained unclear whether the amount of fecal fat excreted in the stool and stool production influences the severity of neonatal jaundice. We determined the relationship between stool production, fecal fat excretion and jaundice in healthy breast-fed (BF) or formula-fed (FF) (near-)term neonates. From postnatal day 1-4, we quantitatively collected stools from 27 FF and 33 BF infants in daily fractions. Stool production and fecal fat contents were related to unconjugated bilirubin (UCB) levels, as determined by transcutaneous bilirubinometry (TcB). Bilirubin concentrations and stool production did not differ between FF and BF neonates during the study period. Neonatal bilirubin levels were not inversely correlated with stool production. FF and BF infants had similar fecal fat excretion rates. The stool production of FF infants was profoundly lower in the present study than in a 1985 study by De Carvalho et al. [J Pediatr (1985) 107:786-790]. We conclude that increased jaundice during the first postnatal days in healthy term neonates can no longer be attributed to breast-feeding and speculate that improved absorbability of formulas since 1985 has contributed to similar fat excretion and stool production in FF and BF neonates in 2007.
authors.affiliation: University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Hannah D
authors.initials: HD
authors.lastname: Buiter
authors.forename: Sebastiaan S P
authors.initials: SS
authors.lastname: Dijkstra
authors.forename: Rob F M
authors.initials: RF
authors.lastname: Oude Elferink
authors.forename: Peter
authors.initials: P
authors.lastname: Bijster
authors.forename: Henk A
authors.initials: HA
authors.lastname: Woltil
authors.forename: Henkjan J
authors.initials: HJ
authors.lastname: Verkade
mesh_terms: D001663:Bilirubin / Q000097:blood; D001724:Birth Weight; D001942:Breast Feeding; D005243:Feces; D005260:Female; D006801:Humans; D041943:Infant Formula; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000378:metabolism*; D008297:Male
chemical_list: D001663:Bilirubin