Hydrophilic hexapeptide Imunofan as a hyperactive regulator of transport proteins for multiple drug resistance.
Hydrophilic hexapeptide Imunofan produces a modulatory effect on multiple drug resistance transport proteins depending on their functional activity. The hexapeptide inhibited multiple drug resistance proteins during substrate transport, but increased their activity in the latent period. By the inhibition of multiple drug resistance, specific activity of Imunofan more than 1000-fold surpassed that of other substrate analogues. Inhibitory analysis showed that regulatory effect of this hexapeptide depends on protein kinase C.
Lebedev
V V
VV
Laboratory of Immunology and Biotechnology, Central Research Institute of Epidemiology, Moscow, Russia. bio.l@mail.ru
Novikov
S A
SA
D001693:Biological Transport, Active / Q000187:drug effects; D002277:Carcinoma / Q000473:pathology; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000037:antagonists & inhibitors; D009842:Oligopeptides / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism
D002352:Carrier Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009842:Oligopeptides; D011493:Protein Kinase C; C080035:thymohexin