First round of a focused library of cholera toxin inhibitors.
C-Galactosides have been used as scaffolds to design a library of non-hydrolysable inhibitors of cholera toxin (CT). Test elements from the library were synthesized and found to inhibit CT binding to an asialofetuin-coated SPR chip with micromolar affinity. Preliminary results are reported.
Podlipnik
Crtomir
C
Dipartimento di Chimica Organica e Industriale, Universita degli Studi di Milano, Via Venezian 21, I-20133 Milano, Italy.
Velter
Ingrid
I
La Ferla
Barbara
B
Marcou
Gilles
G
Belvisi
Laura
L
Nicotra
Francesco
F
Bernardi
Anna
A
D000992:Antitoxins / Q000737:chemistry* / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002772:Cholera Toxin; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry / Q000494:pharmacology
D000992:Antitoxins; D006027:Glycosides; D009844:Oligosaccharides; D002772:Cholera Toxin