title: Tablet formulation studies on nimesulide and meloxicam-cyclodextrin binary systems.
abstract: The objective of this work was to develop tablet formulations of nimesulide-beta-cyclodextrin (NI-beta-CD) and meloxicam-gamma-cyclodextrin (ME-gamma-CD) binary systems. In the case of nimesulide, 3 types of binary systems--physical mixtures, kneaded systems, and coevaporated systems--were studied. In the case of meloxicam, 2 types of binary systems--physical mixtures and kneaded systems--were investigated. Both drug-CD binary systems were prepared at 1:1 and 1:2 molar ratio (1:1M and 1:2M) and used in formulation studies. The tablet formulations containing drug-CD binary systems prepared by the wet granulation and direct compression methods showed superior dissolution properties when compared with the formulations of the corresponding pure drug formulations. Overall, the dissolution properties of tablet formulations prepared by the direct compression method were superior to those of tablets prepared by the wet granulation method. Selected tablet formulations showed good stability with regard to drug content, disintegration time, hardness, and in vitro dissolution properties over 6 months at 40 degrees C +/- 2 degrees C and 75% relative humidity.
authors.affiliation: Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India.
authors.forename: Buchi N
authors.initials: BN
authors.lastname: Nalluri
authors.forename: K P R
authors.initials: KP
authors.lastname: Chowdary
authors.forename: K V R
authors.initials: KV
authors.lastname: Murthy
authors.forename: G
authors.initials: G
authors.lastname: Becket
authors.forename: Peter A
authors.initials: PA
authors.lastname: Crooks
mesh_terms: D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D000077239:Meloxicam; D012995:Solubility; D013449:Sulfonamides / Q000737:chemistry*; D013607:Tablets; D013843:Thiazines / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*; D047408:gamma-Cyclodextrins / Q000737:chemistry*
chemical_list: D013449:Sulfonamides; D013607:Tablets; D013843:Thiazines; D013844:Thiazoles; D047392:beta-Cyclodextrins; D047408:gamma-Cyclodextrins; C031215:betadex; C023792:gamma-cyclodextrin; C012655:nimesulide; D000077239:Meloxicam