title: Antidegenerative effects of partial disc replacement in an animal surgery model.
abstract: METHODS
  In vivo degenerative changes of rabbit intervertebral discs after partial disc replacements were evaluated radiologically and histologically in a controlled trial.
  
  
  OBJECTIVE
  To demonstrate the therapeutic effects of partial disc replacement in an animal surgical model.
  
  
  BACKGROUND
  Although some authors reported that partial disc replacements have beneficial clinical outcomes, there are few controlled animal studies in which the therapeutic effects of this procedure have been demonstrated.
  
  
  METHODS
  The implants for partial disc replacements were made of poly (vinyl alcohol) hydrogel and rod-shaped. The L2-L3 or L3-L4 intervertebral discs of Japanese white rabbits were pierced with a 2.0-mm Kirschner wire and implants were inserted into the holes. For comparative purposes, the adjacent discs underwent sham treatments or control treatments in which the disc was pierced but no implant was inserted. Sixty discs from 30 rabbits were analyzed radiologically and histologically for degenerative changes at 1, 3, or 6 months after surgery.
  
  
  RESULTS
  Radiologic analysis revealed that significantly less disc height was lost with the replacement treatment than with the control treatment. Change in disc height after the replacement treatment was not significantly different from that after the sham treatment. Histologic degeneration of the replaced discs was delayed in comparison with that of the control discs but progressed with time.
  
  
  CONCLUSIONS
  The antidegenerative effects of partial disc replacement surgery were demonstrated by quantitative radiologic and histologic analyses. Degeneration of the anulus fibrosus after the replacement treatment was delayed by preserving disc height and occupying the space of the nucleus pulposus. Properly designed implants and minimally invasive techniques are necessary for long-term success.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: So
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Takemoto
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Fujibayashi
authors.forename: Masashi
authors.initials: M
authors.lastname: Neo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kyomoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Hayami
authors.forename: Suong-Hyu
authors.initials: SH
authors.lastname: Hyon
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000592:standards* / Q000627:therapeutic use; D007403:Intervertebral Disc / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007405:Intervertebral Disc Displacement / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D019635:Neurosurgical Procedures / Q000295:instrumentation* / Q000379:methods; D019736:Prostheses and Implants / Q000592:standards*; D011817:Rabbits; D019651:Plastic Surgery Procedures / Q000295:instrumentation* / Q000379:methods; D013131:Spine / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate