Papillomatosis of intra- and extrahepatic biliary tree: Successful treatment with liver transplantation.
Approximately 60 cases of biliary papillomatosis have been reported in the world literature, while only 6 cases have been reported to be treated with liver transplantation. This rare disease, which is characterized by relapsing episodes of obstructive jaundice and cholangitis that lead to secondary cirrhosis and death from sepsis or liver failure, it is also considered premalignant because of its frequent malignant transformation (25-50%). We present a case of a 43-year-old white man with papillomatosis of intra- and extrahepatic biliary tree who sought care for repeated episodes of obstructive jaundice and cholangitis. The diagnosis was suspected after endoscopic retrograde cholangiopancreatography and confirmed by liver and common bile duct biopsies. The patient underwent orthotopic liver transplantation with Roux-en-Y hepatico-jejunostomy to treat end-stage liver cirrhosis. Fifteen months' follow-up revealed a patient with normal graft function and with no clinically or laboratory findings of disease recurrence or cancer development.
Imvrios
George
G
Department of Transplant Surgery, Aristotle University, Hippokration Hospital, Thessaloniki, Greece.
Papanikolaou
Vasilios
V
Lalountas
Miltiadis
M
Patsiaoura
Kaliopi
K
Giakoustidis
Dimitrios
D
Fouzas
Ioannis
I
Anagnostara
Eva
E
Antoniadis
Nikolaos
N
Takoudas
Dimitrios
D
D000328:Adult; D017734:Bile Ducts, Extrahepatic / Q000000981:diagnostic imaging / Q000821:virology*; D001653:Bile Ducts, Intrahepatic / Q000000981:diagnostic imaging / Q000821:virology*; D001659:Biliary Tract / Q000821:virology*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003135:Common Bile Duct / Q000473:pathology / Q000821:virology; D005500:Follow-Up Studies; D005705:Gallbladder Diseases / Q000000981:diagnostic imaging / Q000601:surgery* / Q000821:virology*; D006801:Humans; D008099:Liver / Q000473:pathology / Q000821:virology; D016031:Liver Transplantation; D008297:Male; D030361:Papillomavirus Infections / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome