title: Active expression of matrix metalloproteinase-13 mRNA in the granulation tissue of equine superficial digital flexor tendinitis.
abstract: The DNA microarray analysis for matrix metalloproteinase (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon. In situ hybridization also revealed that fibroblastic cells proliferated in the granulation tissue generated in the tendinitis actively expressed MMP-13 mRNA. On the other hand, in normal tendon, a few fibroblastic cells and vascular components lied in the endotenon barely expressed its mRNA, but other cellular components in the tendon bundle were not positively hybridized. As mentioned above, MMP-13 but not other collagenases or gelatinases, may play an important role in tendon injuries in the racehorses.
authors.affiliation: Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nomura
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Hosaka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kasashima
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ueda
authors.forename: Kazushige
authors.initials: K
authors.lastname: Takehana
authors.forename: Atsutoshi
authors.initials: A
authors.lastname: Kuwano
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Arai
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006097:Granulation Tissue / Q000378:metabolism*; D006734:Horse Diseases / Q000378:metabolism*; D006736:Horses; D008297:Male; D053509:Matrix Metalloproteinase 13 / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D052256:Tendinopathy / Q000378:metabolism*; D013710:Tendons / Q000201:enzymology
chemical_list: D012333:RNA, Messenger; D053509:Matrix Metalloproteinase 13