Direct lactone formation by using hypervalent iodine(III) reagents with KBr via selective C-H abstraction protocol.
We have developed a new and reliable method for the direct construction of biologically important aryl lactones and phthalides from carboxylic and benzoic acids, using a combination of hypervalent iodine(III) reagents with KBr.
Dohi
Toshifumi
T
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871 Japan.
Takenaga
Naoko
N
Goto
Akihiro
A
Maruyama
Akinobu
A
Kita
Yasuyuki
Y
D001565:Benzoates / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D007202:Indicators and Reagents; D007455:Iodine / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis*; D015394:Molecular Structure; D010797:Phthalimides / Q000138:chemical synthesis*; D017680:Potassium Compounds / Q000737:chemistry*
D001565:Benzoates; D001965:Bromides; D002264:Carboxylic Acids; D007202:Indicators and Reagents; D007783:Lactones; D010797:Phthalimides; D017680:Potassium Compounds; D007455:Iodine; C039004:potassium bromide