Alkylation of active methylene compounds with alcohols catalyzed by an iridium complex.
Base-free catalytic alpha-alkylation of active methylene compounds with primary alcohols was successfully achieved using an [IrCl(cod)](2) complex in the presence of PPh(3) to afford the corresponding saturated alpha-alkylated products in good yields.
Morita
Masao
M
Department of Applied Chemistry, Faculty of Engineering, Kansai University, Yamate-cho, Suita, Osaka 564-8680, Japan.
Obora
Yasushi
Y
Ishii
Yasutaka
Y