Diffuse large B-cell lymphoma in hyperimmunoglobulinemia E syndrome.
We report a case of diffuse large B-cell lymphoma occurring in a patient with the hyperimmunoglobulinemia E syndrome, a rare immune disorder defined by elevated immunoglobulin E levels and recurrent bacterial and fungal infections often manifesting as cold abscesses. This case further supports the notion that patients with hyperimmunoglobulinemia E have an increased risk of lymphoid malignancies and should be closely monitored. Despite a theoretic risk of severe infectious complications, chemotherapy was well tolerated and resulted in a sustained complete remission.
Wallet
Nadège
N
Service d'Hématologie Adultes et Centre d'Etudes et de Recherche sur les Déficits Immunitaires Héréditaires, Hôpital Necker-Enfants Malades, 149-163 rue de Sèvres, 75743 Paris, France.
Ghez
David
D
Delarue
Richard
R
Suarez
Felipe
F
Rubio
Marie-Thérèse
MT
Fischer
Alain
A
Canioni
Danielle
D
Varet
Bruno
B
Hermine
Olivier
O
D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007589:Job Syndrome / Q000150:complications*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D000069283:Rituximab; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D007073:Immunoglobulin E; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide