title: ACR Appropriateness Criteria on treatment of anal cancer.
abstract: Anal cancer is a relatively rare neoplasm, accounting for roughly 4,500 cases per year. The evolution of the definitive treatment of anal cancer from a surgical to a nonsurgical approach, however, has been viewed as a model disease site in a larger paradigm shift in medicine. Organ preservation, in this case a functional anal sphincter, and durable cure are obtainable goals. To this end, anal cancer is a disease best treated primarily with chemoradiation. Although appropriate treatment can produce acceptable results, further investigation and improvement in therapy are still needed.
authors.affiliation: National Naval Medical Center, Department of Radiation Oncology, Bethesda, Md 20889-5000, USA. mmpoggi@bethesda.med.navy.mil
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Poggi
authors.forename: W Warren
authors.initials: WW
authors.lastname: Suh
authors.forename: Leonard
authors.initials: L
authors.lastname: Saltz
authors.forename: Andre A
authors.initials: AA
authors.lastname: Konski
authors.forename: Mohammed
authors.initials: M
authors.lastname: Mohiuddin
authors.forename: Joseph
authors.initials: J
authors.lastname: Herman
authors.forename: Peter A
authors.initials: PA
authors.lastname: Johnstone
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D009367:Neoplasm Staging; D011237:Predictive Value of Tests
chemical_list: D000970:Antineoplastic Agents; D016685:Mitomycin; D002945:Cisplatin