Developing with BDNF: a moving experience.
During development, newly born neurons migrate away from their initial birth sites to their final positions in the mature brain. The neurotrophin BDNF has been shown to regulate the migration of granule cells in the cerebellum. The cellular mechanisms that mediate this chemotactic response have not been resolved. In this issue of Neuron, Zhou et al. show that vesicle trafficking is critical for allowing neurons to respond to a gradient of BDNF.
Kaplan
David R
DR
Cell Biology Program, Hospital for Sick Children, Toronto, M5G 1L7 ON, Canada. dkaplan@sickkids.ca
Miller
Freda D
FD
D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development*; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D002633:Chemotaxis / Q000502:physiology; D006801:Humans; D051379:Mice; D020813:Receptor, trkB / Q000502:physiology
D019208:Brain-Derived Neurotrophic Factor; D020813:Receptor, trkB