title: Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats.
abstract: Hydro-ethanolic extract (70%) of Calotropis procera flowers was prepared and tested for its hepatoprotective effect against paracetamol-induced hepatitis in rats. Alteration in the levels of biochemical markers of hepatic damage like SGPT, SGOT, ALP, bilirubin, cholesterol, HDL and tissue GSH were tested in both treated and untreated groups. Paracetamol (2 g/kg) has enhanced the SGPT, SGOT, ALP, bilirubin and cholesterol levels and reduced the serum levels of HDL and tissue level of GSH. Treatment with hydro-ethanolic extract of C. procera flowers (200 mg/kg and 400 mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner.
authors.affiliation: Department of Pharmacology, S. C. S. College of Pharmacy, Davanagere, Karnataka, India. rssiddamsetty@rediffmail.com
authors.forename: S
authors.initials: S
authors.lastname: Ramachandra Setty
authors.forename: Absar Ahmed
authors.initials: AA
authors.lastname: Quereshi
authors.forename: A H M
authors.initials: AH
authors.lastname: Viswanath Swamy
authors.forename: Tushar
authors.initials: T
authors.lastname: Patil
authors.forename: T
authors.initials: T
authors.lastname: Prakash
authors.forename: K
authors.initials: K
authors.lastname: Prabhu
authors.forename: A
authors.initials: A
authors.lastname: Veeran Gouda
mesh_terms: D000082:Acetaminophen; D018712:Analgesics, Non-Narcotic; D000818:Animals; D031107:Calotropis; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D035264:Flowers; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D020011:Protective Agents; D000082:Acetaminophen