Histatin-derived monomeric and dimeric synthetic peptides show strong bactericidal activity towards multidrug-resistant Staphylococcus aureus in vivo.
Homodimerization of histatin-derived peptides generally led to improved bactericidal activity against Staphylococcus aureus in vitro. In vivo, monomers and dimers were equally active in killing bacteria in mice with a soft tissue infection. Altogether, these peptides are promising compounds for the development of novel therapeutics against infections with drug-resistant bacteria.
Welling
Mick M
MM
Section Nuclear Medicine, Division of Radiology, Leiden University Medical Center, Room C4-R-77, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. m.m.welling@lumc.nl
Brouwer
Carlo P J M
CP
van 't Hof
Wim
W
Veerman
Enno C I
EC
Amerongen
Arie V Nieuw
AV
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D016106:Methicillin Resistance / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects*; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents