title: Effects of acetazolamide on aerobic exercise capacity and pulmonary hemodynamics at high altitudes.
abstract: Aerobic exercise capacity is decreased at altitude because of combined decreases in arterial oxygenation and in cardiac output. Hypoxic pulmonary vasoconstriction could limit cardiac output in hypoxia. We tested the hypothesis that acetazolamide could improve exercise capacity at altitude by an increased arterial oxygenation and an inhibition of hypoxic pulmonary vasoconstriction. Resting and exercise pulmonary artery pressure (Ppa) and flow (Q) (Doppler echocardiography) and exercise capacity (cardiopulmonary exercise test) were determined at sea level, 10 days after arrival on the Bolivian altiplano, at Huayna Potosi (4,700 m), and again after the intake of 250 mg acetazolamide vs. a placebo three times a day for 24 h. Acetazolamide and placebo were administered double-blind and in a random sequence. Altitude shifted Ppa/Q plots to higher pressures and decreased maximum O(2) consumption ((.)Vo(2max)). Acetazolamide had no effect on Ppa/Q plots but increased arterial O(2) saturation at rest from 84 +/- 5 to 90 +/- 3% (P < 0.05) and at exercise from 79 +/- 6 to 83 +/- 4% (P < 0.05), and O(2) consumption at the anaerobic threshold (V-slope method) from 21 +/- 5 to 25 +/- 5 ml.min(-1).kg(-1) (P < 0.01). However, acetazolamide did not affect (.)Vo(2max) (from 31 +/- 6 to 29 +/- 7 ml.kg(-1).min(-1)), and the maximum respiratory exchange ratio decreased from 1.2 +/- 0.06 to 1.05 +/- 0.03 (P < 0.001). We conclude that acetazolamide does not affect maximum exercise capacity or pulmonary hemodynamics at high altitudes. Associated changes in the respiratory exchange ratio may be due to altered CO(2) production kinetics.
authors.affiliation: Laboratory of Physiology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium.
authors.forename: Vitalie
authors.initials: V
authors.lastname: Faoro
authors.forename: Sandrine
authors.initials: S
authors.lastname: Huez
authors.forename: Sébastien
authors.initials: S
authors.lastname: Giltaire
authors.forename: Adriana
authors.initials: A
authors.lastname: Pavelescu
authors.forename: Aurélie
authors.initials: A
authors.lastname: van Osta
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Moraine
authors.forename: Hervé
authors.initials: H
authors.lastname: Guenard
authors.forename: Jean-Benoît
authors.initials: JB
authors.lastname: Martinot
authors.forename: Robert
authors.initials: R
authors.lastname: Naeije
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D000531:Altitude; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D004311:Double-Blind Method; D015444:Exercise; D017079:Exercise Tolerance / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D011652:Pulmonary Circulation / Q000187:drug effects* / Q000502:physiology
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D000086:Acetazolamide