[Effect of heavy metal mixture on the main functions of the central nervous system].
The influence of heavy metals salts mix, the most widespread pollutants of Prydnieprovsky region natural reservoirs on animal behavioral reactions, memory processes and total bioelectric activity of various brain departments has been investigated. It was revealed that heavy metals consumption with drinking water results in the development of the neurotization processes, at that due to animals hyperactivity there is an exhaustion of nervous centers that is reflected by prolongation of immobility periods in animals. Increase of the latent period of conditioned reflex formation in the 8th radial labyrinth together with decrease of task fulfillment efficiency indicate deterioration of the training ability of these animals and impairment of their short-term memory. Meaningful changes in total neocortex bioelectric activity (strengthening in specters of theta- and beta-ranges and weakening in alpha-waves area), dorsal hyppocampus (strengthening of spectral capacity in theta- and its weakening in at-range) and fore-part hypothalamus (decrease of spectral capacity in the high-frequency area) are shown. It allows us to make the conclusion about significant changes in the brain cortex and in the cortical-subcortical interactions under the influence of heavy metal salts. Reaction of the hind hypothalamus differed from the reaction described above and came to strengthening of the spectrum capacity in high-frequency ranges and to weakening in low-frequency ones, that testifies the raised sensitivity of this brain department to the heavy metals action.
Severynovs'ka
O V
OV
Hryhorova
M O
MO
Zaĭchenko
O Iu
OIu
Kasymova
K I
KI
Dvorets'kyĭ
A I
AI
Rybal'chenko
V K
VK
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D004569:Electroencephalography; D018782:Maze Learning / Q000187:drug effects; D019216:Metals, Heavy / Q000633:toxicity*; D051381:Rats; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D019216:Metals, Heavy; D014874:Water Pollutants, Chemical