[In vitro microstructural analysis of commercial ophthalmic suspensions by HRT II Rostock Cornea Module].
BACKGROUND
To investigate the particles of commercially used ophthalmic suspensions with the HRT II Rostock Cornea Module and to compare them with particle parameters given in the literature.


METHODS
Software-aided analysis was carried out for the suspensions brinzolamide 1%, betaxolol HCl 0.25%, dexamethasone phosphate 0.1% and prednisolone acetate 0.5%, including measurements of length, area and circumference and calculation of ellipticity and shape factor (SF).


RESULTS
Particle characteristics (SF and ellipticity) of different suspensions demonstrated that the particles are not spherical. Significant aggregation affinity of prednisolone acetate particles was observed.


CONCLUSIONS
Exact and reproducible in vitro microstructural examination of ophthalmic suspensions was possible due to the high resolution of the HRT II Rostock Cornea Module.
Imre
L
L
Klinik für Augenheilkunde, Semmelweis Universität Budapest, Tömo u.25-29, 1083, Budapest, Ungarn. imrelaszlo@t-online.hu
Resch
M
M
Megyesi
M
M
Németh
J
J
D015784:Betaxolol / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003102:Colloids / Q000737:chemistry; D003907:Dexamethasone / Q000737:chemistry*; D018613:Microscopy, Confocal / Q000295:instrumentation* / Q000379:methods; D009883:Ophthalmic Solutions / Q000737:chemistry*; D010316:Particle Size; D011239:Prednisolone / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry*; D013535:Suspensions; D013843:Thiazines / Q000737:chemistry*
D003102:Colloids; D009883:Ophthalmic Solutions; D013449:Sulfonamides; D013535:Suspensions; D013843:Thiazines; D003907:Dexamethasone; C111827:brinzolamide; D011239:Prednisolone; D015784:Betaxolol