A new cytotoxic phenazine derivative from a deep sea bacterium Bacillus sp.
A novel phenazine derivative (1) together with six known compounds (2-7) were isolated by bioassay-guided fractionation from the culture broth of a bacterium, Bacillus sp., collected from a Pacific deep sea sediment sample (depth 5059 m). The structures of these compounds were determined using spectroscopic methods. Their cytotoxic effects on P388 and K562 cell lines were preliminarily examined using the sulforhodamine-B (SRB) assay.
Li
Dehai
D
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, PR China.
Wang
Fengping
F
Xiao
Xiang
X
Zeng
Xiang
X
Gu
Qian-Qun
QQ
Zhu
Weiming
W
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D001407:Bacillus / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D007941:Leukemia P388; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014871:Water Microbiology
D000903:Antibiotics, Antineoplastic; D010619:Phenazines