Thyroid-state influence on protein-expression profile of rat skeletal muscle.
We analyzed the whole-cell protein content of gastrocnemius muscles from rats in different thyroid states. Twenty differentially expressed proteins were unambiguously identified. They were involved in substrates and energy metabolism, stress response, cell structure, and gene expression. This study represents the first systematic identification of thyroid state-induced changes in the skeletal muscle protein-expression profile and reveals new cellular pathways as targets for thyroid hormone action.
Silvestri
Elena
E
Dipartimento di Scienze Biologiche ed Ambientali, Università degli Studi del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy.
Burrone
Lavinia
L
de Lange
Pieter
P
Lombardi
Assunta
A
Farina
Paola
P
Chambery
Angela
A
Parente
Augusto
A
Lanni
Antonia
A
Goglia
Fernando
F
Moreno
Maria
M
D000818:Animals; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013963:Thyroid Hormones / Q000494:pharmacology
D009124:Muscle Proteins; D020543:Proteome; D012333:RNA, Messenger; D013963:Thyroid Hormones