Aortic valve replacement in a patient with severe hemophilia.
Hemophilia A is an inherited bleeding disorder characterized by factor VIII deficiency. The basis for insufficient hemostasis lies within inadequate amplification of factor Xa production with the undersupplied factor VIII. We report on a young patient with critical aortic stenosis bearing all the clinical stigmata of severe hemophilia, in whom aortic valve replacement was performed with a tissue valve in order to avoid the need for long term anticoagulation.
Gasparović
Hrvoje
H
Department of Cardiac Surgery, University Hospital Rebro Zagreb, Croatia. hgasparovic@kbc-zagreb.hr
Zupancic-Salek
Silva
S
Brida
Vojtjeh
V
Dulić
Grgur
G
Jelić
Ivan
I
D001021:Aortic Valve / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000601:surgery*; D005169:Factor VIII / Q000008:administration & dosage; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005169:Factor VIII