[Involvement of ionotropic glutamate receptors in the genesis of arecoline-induced tremor].
The muscarinic agonist arecoline (6 mg/kg, subcutaneously in mice) induced a long-lasting tremor. The inhibitory potency of non-competitive antagonists of ionotropic glutamate receptors has been studied. These antagonists are the derivatives of adamantane and phenylcyclohexyl. A part of them: monocationic compounds, selectively block the NMDA-receptor channels, their dicationic analogues affecting both channels of the NMDA- and the AMPA-glutamate receptors. Monocationic blockers effectively reduced the arecoline-evoked tremor and their potency correlated with ability to block the NMDA-receptor channels. Dicationic blockers revealed protective effect only in low range doses (0.0001-0.01 microM/kg). Further increase of the dose reduced or completely abolished this effect. This suggests that the NMDA-receptors are involved in the genesis of arecoline-evoked tremor. The only moderate blockade of the AMPA-receptors potentiates the drug blocking action but the prevalent blockade of these receptors impedes the effect on arecoline-evoked tremor.
Lukomskaia
N Ia
NIa
Lavrent'eva
V V
VV
Starshinova
L A
LA
Zhabko
E P
EP
Gmiro
V E
VE
Magazanik
L G
LG
D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D018679:Cholinergic Agonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D018091:Receptors, AMPA / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D014202:Tremor / Q000139:chemically induced* / Q000378:metabolism*
D018679:Cholinergic Agonists; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D001115:Arecoline