title: Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia.
abstract: Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia-lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV-1-associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV-1 replication by Strongyloides, which resolved with anti-helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T-cell stimulation.
authors.affiliation: Division of Oncology, Washington University, St. Louis, Missouri 63110, USA. lratner@im.wustl.edu
authors.forename: Lee
authors.initials: L
authors.lastname: Ratner
authors.forename: Christian
authors.initials: C
authors.lastname: Grant
authors.forename: Bevin
authors.initials: B
authors.lastname: Zimmerman
authors.forename: Joseph
authors.initials: J
authors.lastname: Fritz
authors.forename: Gary
authors.initials: G
authors.lastname: Weil
authors.forename: Alex
authors.initials: A
authors.lastname: Denes
authors.forename: Rama
authors.initials: R
authors.lastname: Suresh
authors.forename: Nancy
authors.initials: N
authors.lastname: Campbell
authors.forename: Steve
authors.initials: S
authors.lastname: Jacobson
authors.forename: Michael
authors.initials: M
authors.lastname: Lairmore
mesh_terms: D000368:Aged; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use; D001213:Asian; D004279:DNA, Viral / Q000097:blood; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007559:Ivermectin / Q000494:pharmacology* / Q000627:therapeutic use; D007564:Japan / Q000453:epidemiology / Q000208:ethnology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D012367:RNA, Viral / Q000097:blood; D013047:Specific Pathogen-Free Organisms; D017171:Strongyloides stercoralis / Q000302:isolation & purification / Q000472:pathogenicity*; D013322:Strongyloidiasis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D019562:Viral Load; D014766:Viremia / Q000150:complications*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000871:Anthelmintics; D004279:DNA, Viral; D012367:RNA, Viral; D007559:Ivermectin