Acellular dermal matrix as a membrane for guided tissue regeneration in the treatment of Class II furcation lesions: a histometric and clinical study in dogs.
BACKGROUND
The purpose of this study was to evaluate acellular dermal matrix (ADM) as a membrane for guided tissue regeneration (GTR) in the treatment of mandibular Class II furcation lesions and to compare it to a bioabsorbable membrane.


METHODS
Class II furcation lesions were created surgically and chronified in six mongrel dogs on the buccal surfaces of mandibular third and fourth premolars, bilaterally. After 1 month, GTR was performed. Each side was assigned randomly to the control group (CGr: bioabsorbable membrane made of polyglycolic acid: trimethylene carbonate) or the test group (TGr: ADM as a membrane). Clinical measurements of the width and thickness of the keratinized tissue (WKT and TKT, respectively) were made before GTR. The dogs were sacrificed 12 weeks following GTR, and histomorphometric analysis was performed. Area measurements were taken of new tissue, epithelium, connective tissue, and new bone; bone height and new cementum were measured.


RESULTS
The formation of new bone, cementum, and periodontal ligament were similar in both groups. There were no statistically significant differences between the groups for any histomorphometric measurement. The TGr had a statistically significant increase in WKT and TKT after 3 months. The mean TKT gain was 1.03 mm for the TGr and 0.26 mm for the CGr (P <0.05).


CONCLUSIONS
The ADM demonstrated histomorphometric results similar to the bioabsorbable membrane and resulted in a greater increase in the thickness of the keratinized tissue.
de Andrade
Patrícia Freitas
PF
Department of Bucco-Maxillo-Facial Surgery and Traumatology and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
de Souza
Sérgio Luís Scombatti
SL
de Oliveira Macedo
Guilherme
G
Novaes
Arthur Belém
AB
de Moraes Grisi
Márcio Fernando
MF
Taba
Mário
M
Palioto
Daniela Bazan
DB
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D004146:Dioxanes / Q000627:therapeutic use; D004285:Dogs; D017823:Furcation Defects / Q000473:pathology / Q000628:therapy*; D005881:Gingiva / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008334:Mandible; D008567:Membranes, Artificial; D011100:Polyglycolic Acid / Q000627:therapeutic use; D017768:Skin, Artificial
C440568:Alloderm; D001672:Biocompatible Materials; D004146:Dioxanes; D008567:Membranes, Artificial; D011100:Polyglycolic Acid; C443643:trimethylene carbonate; D003094:Collagen