Tumoral calcinosis producing peripheral nerve compression: a report of two cases.
Tumoral calcinosis is a rare disorder that leads to diffuse calcium phosphate deposition into soft tissue and may be seen in the setting of uremia, hyperparathyroidism, or vitamin D intoxication. This lesion can produce significant local pain and can limit mobility in large joints where it tends to occur. Less commonly, it may produce neurological symptoms by compressing or encompassing adjacent neurovascular structures. Tumoral calcinosis involving nerve structures is challenging to treat, primarily because of its extensive size and propensity to infiltrate. Although surgical intervention can often provide symptomatic improvement, this lesion tends to recur in the presence of elevated calcium phosphate levels, and its management therefore requires a combined multidisciplinary surgical and medical approach. The authors describe two cases in which patients developed tumoral calcinosis producing peripheral nerve compression and discuss their respective surgical and medical management.
Williams
Ziv
Z
Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55902, USA.
Amrami
Kimberly K
KK
Spinner
Robert J
RJ
D000328:Adult; D002114:Calcinosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009408:Nerve Compression Syndromes / Q000473:pathology / Q000601:surgery*; D010523:Peripheral Nervous System Diseases / Q000473:pathology / Q000601:surgery*