title: Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex.
abstract: Semax had a pronounced neuroprotective and antiamnesic effect during focal photoinduced ischemia of the prefrontal cortex. Intranasal administration of Semax for 6 days decreased the volume of cortical infarction and improved retention and performance of conditioned passive avoidance response.
authors.affiliation: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. romanovaga@mail.ru
authors.forename: G A
authors.initials: GA
authors.lastname: Romanova
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
authors.forename: F M
authors.initials: FM
authors.lastname: Shakova
authors.forename: Yu N
authors.initials: YN
authors.lastname: Kvashennikova
authors.forename: I V
authors.initials: IV
authors.lastname: Viktorov
authors.forename: S I
authors.initials: SI
authors.lastname: Shram
authors.forename: N F
authors.initials: NF
authors.lastname: Myasoedov
mesh_terms: D000281:Administration, Intranasal; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000647:Amnesia / Q000188:drug therapy*; D000818:Animals; D021461:Animals, Outbred Strains; D020520:Brain Infarction / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000150:complications; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone