[Study on the mechanism of scar formation: epidermis template defect theory].
Dermal defection and the degree of its loss determine the natural process of wound healing, which is the key reason leading to excess scar hyperplasia. The function of tri-dimensional structure in dermis acts as a template to regulate the properties of reparative cells. The template structure induces the reparative cells to grow into the structure which changes the skin mechanic status on wound area. Also, the component of extracellular matrix can affect behaviours of fibroblasts negatively or positively, for the reason that the structure of dermal tissue has a permissive effect on the dermal components in regulating behaviours of reparative cells. Therefore, the behaviors of cells depend on the structure of the template. The suitable tri-dimensional structure of dermis facilitates normal cell cycling. The more the structure of dermis closed to its physiological status, the better the biological behaviors of cells act. Moreover, the integrity as well as the continuity of dermal tissue is the prerequisite for serving as a template. The damage to the integrity and the continuity of dermal tissue may be one of the key reasons to lead abnormal tissue repair and scar formation. Thus, we hypothesize that the loss of dermal template may be one of the mechanism of abnormal scar formation and propose the theory of extracellular matrix framework deficiency or destruction.
Lu
Shu-liang
SL
Department of Burns , Ruijin Hospital , Medical College of Shanghai Jiaotong University , Shanghai 200025 , PR China sllu@sh163.net
Qin
Chun
C
Liu
Ying-kai
YK
Wang
Xi-qiao
XQ
Xiang
Jun
J
Mao
Zhi-gang
ZG
Zhang
Fu-sheng
FS
Jin
Shu-wen
SW
Dong
Jiao-yun
JY
Hua
Lan-nv
LN
D002921:Cicatrix / Q000473:pathology*; D020405:Dermis / Q000473:pathology*; D004817:Epidermis / Q000473:pathology; D006801:Humans; D014945:Wound Healing