Multidrug-resistant Providencia isolates carrying blaPER-1, blaVIM-2, and armA.
During May to July 2004, three strains of Providencia spp. with multidrug-resistance (MDR) were isolated from urinary specimen of three patients hospitalized with a same hospital room. By PCR analysis, all three strains have been found to carry both VIM-2 type metallo-beta-lactamase gene and PER-1 type extendedspectrum beta-lactamase gene. One out of three strains carried additional resistance gene, armA, 16S rRNA methylase gene responsible for high level resistance to aminoglycosides. To our knowledge, this is the first report on the identification of Providencia spp. simultaneously carrying blaVIM-2, blaPER-1, and armA genes.
Lee
Hee-Woo
HW
Department of Microbiology, Kyungpook National University, School of Medicine, Daegu, Republic of Korea.
Kang
Hee-Young
HY
Shin
Kyeong-Seob
KS
Kim
Jungmin
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D006801:Humans; D008780:Methyltransferases / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D011532:Providencia / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D014552:Urinary Tract Infections / Q000382:microbiology*; D001618:beta-Lactamases / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D008780:Methyltransferases; C108863:beta-lactamase PER-1; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases