title: Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults.
abstract: The aim of the present study was to evaluate whether soluble triggering receptor expressed on myeloid cells (sTREM-1) is present in the cerebrospinal fluid (CSF) of patients with acute meningitis and if its presence can predict bacterial infection. We found elevated levels of sTREM-1 in the CSF of seven of the nine (78%) patients with culture-positive specimens and in none of 12 (0%) patients with culture-negative specimens (sensitivity: 78%; specificity: 100%). The area under the receiver operating characteristic curve for sTREM-1 in the CSF as a predictor for bacterial meningitis was 0.889. This suggests that sTREM-1 is upregulated in the CSF of patients with bacterial meningitis with high specificity and that its presence can potentially assist clinicians in the diagnosis of bacterial meningitis.
authors.affiliation: Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. bishara@netvision.net.il
authors.forename: J
authors.initials: J
authors.lastname: Bishara
authors.forename: N
authors.initials: N
authors.lastname: Hadari
authors.forename: M
authors.initials: M
authors.lastname: Shalita-Chesner
authors.forename: Z
authors.initials: Z
authors.lastname: Samra
authors.forename: O
authors.initials: O
authors.lastname: Ofir
authors.forename: M
authors.initials: M
authors.lastname: Paul
authors.forename: N
authors.initials: N
authors.lastname: Peled
authors.forename: S
authors.initials: S
authors.lastname: Pitlik
authors.forename: Y
authors.initials: Y
authors.lastname: Molad
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000134:cerebrospinal fluid*; D008582:Meningitis, Aseptic / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011971:Receptors, Immunologic; D012680:Sensitivity and Specificity; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1