title: Endocrine predictors of mortality in canine babesiosis caused by Babesia canis rossi.
abstract: This prospective, cross-sectional, observational study was designed to determine the association between the hormones of the pituitary-adrenal and pituitary-thyroid axes and outcome in dogs with naturally occurring Babesia canis rossi babesiosis. Ninety-five dogs with canine babesiosis were studied and blood samples were obtained from the jugular vein in each dog prior to treatment at admission to hospital. Serum cortisol, adrenocorticotrophic hormone (ACTH), thyroxine, free thyroxine and thyrotropin (TSH) concentrations were measured. Diagnosis was confirmed by polymerase chain reaction and reverse line blot and dogs infected with Babesia canis vogeli or Ehrlichia canis were excluded. Three outcomes were defined: hospitalization with subsequent death (n=7); hospitalization followed by recovery (n=56); and treatment as an outpatient (n=32). Serum cortisol and ACTH concentrations were significantly higher in the dogs that died, compared to hospitalized dogs that survived and compared to dogs treated as outpatients. Serum T4 and free T4 concentrations were significantly lower in the dogs that died, compared to the hospitalized dogs that survived and compared to dogs treated as outpatients. Serum TSH concentrations were not significantly different between any of the groups. Mortality was significantly associated with high cortisol and high ACTH concentrations and with low T4 and fT4 concentrations in dogs suffering from B. canis rossi babesiosis.
authors.affiliation: Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, South Africa. johanp.schoeman@up.ac.za
authors.forename: Johan P
authors.initials: JP
authors.lastname: Schoeman
authors.forename: Philip
authors.initials: P
authors.lastname: Rees
authors.forename: Michael E
authors.initials: ME
authors.lastname: Herrtage
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001403:Babesia; D001404:Babesiosis / Q000097:blood / Q000188:drug therapy / Q000401:mortality / Q000662:veterinary*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy / Q000401:mortality*; D004285:Dogs; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D015415:Biomarkers; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D013974:Thyroxine; D006854:Hydrocortisone