title: Controlling seizures is not controlling epilepsy: a parametric study of deep brain stimulation for epilepsy.
abstract: Pharmacological inhibition and high-frequency stimulation (HFS) of the substantia nigra pars reticulata (SNr) suppress seizures in different animal models of epilepsy. The aim of the present study was to determine the optimal parameters of HFS to control spontaneous seizures in a genetic model of absence epilepsy in the rat. Single SNr stimulation that was bilateral, bipolar and monophasic at 60 Hz frequency and with 60-micros pulse width was optimal. However, when used for repeated stimulations, long-term suppression did not occur and even the number of seizures increased. A delay of at least 60 s between stimulations was necessary to be fully effective. Although single HFS of the SNr can be used to suppress ongoing seizures, repeated HFS is ineffective and could even aggravate seizures in our model. Thus investigations of accurate stimulation procedures are still needed.
authors.affiliation: University of Munich, Klinikum Grosshadern, Department of Neurology, Marchioninistr. 15, 81377 Munich, Germany.
authors.forename: Berend
authors.initials: B
authors.lastname: Feddersen
authors.forename: Laurent
authors.initials: L
authors.lastname: Vercueil
authors.forename: Soheyl
authors.initials: S
authors.lastname: Noachtar
authors.forename: Olivier
authors.initials: O
authors.lastname: David
authors.forename: Antoine
authors.initials: A
authors.lastname: Depaulis
authors.forename: Colin
authors.initials: C
authors.lastname: Deransart
mesh_terms: D000818:Animals; D046690:Deep Brain Stimulation / Q000379:methods*; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications / Q000628:therapy*; D004832:Epilepsy, Absence / Q000150:complications / Q000628:therapy*; D051381:Rats; D013378:Substantia Nigra / Q000502:physiology*