Pharmacological management of gestational diabetes: an overview.
OBJECTIVE
To provide a review of the background literature regarding the pharmacological management of gestational diabetes.


METHODS
This is a literature review.


RESULTS
Information is available regarding the use of some, but not all, oral antidiabetes agents in pregnancy.


CONCLUSIONS
Available evidence supports the use of glyburide during pregnancy. Evidence is inadequate to support or refute the use of metformin, an agent that has been shown to cross the placenta and thus could be helpful or harmful to the developing fetus.
Coustan
Donald R
DR
Department of Obstetrics and Gynecology, Brown Medical School, Women & Infants Hospital of Rhode Island, 101 Dudley St., Providence, RI 02905-2401, USA. dcoustan@wihri.org
D016640:Diabetes, Gestational / Q000188:drug therapy*; D005260:Female; D005905:Glyburide; D006801:Humans; D007004:Hypoglycemic Agents / Q000145:classification / Q000627:therapeutic use*; D008687:Metformin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D011247:Pregnancy
D007004:Hypoglycemic Agents; D008687:Metformin; D005905:Glyburide