Parameters obtained by hepatobiliary scintigraphy have significant correlation with biochemical factors early after liver transplantation.
BACKGROUND
Early postoperative hepatobiliary scintigraphy after liver transplantation is performed worldwide, but data on its significance for graft function are currently limited.


OBJECTIVE
To examine the correlation between the result of early postoperative hepatobiliary scintigraphy and pre- and postoperative biochemical parameters in liver transplantation (LTx) patients.


METHODS
Six parameters of hepatobiliary scintigraphy using (99m)Tc mebrofenin were statistically analyzed in 108 LTx patients: 1) half-life of the activity of elimination of mebrofenin from the blood; 2) total clearance of mebrofenin from the blood due to all possible routes; 3) half-life of the activity due to liver uptake; 4) clearance of mebrofenin from the blood due to liver uptake; 5) time to maximal uptake in the liver; and 6) the hepatic extraction fraction (HEF) and biochemical data. Analysis between patients with preoperative normal liver function, familial amyloid polyneuropathy (FAP), and end-stage liver disease (non-FAP) was also performed.


RESULTS
Univariate and multivariate analysis revealed that total bilirubin postoperative day 3 correlated with all three scintigraphic parameters, and peak aspartate aminotransferase and alanine aminotransferase correlated with HEF. The analysis between patients with FAP and non-FAP revealed no significant difference of scintigraphic data between the two groups.


CONCLUSIONS
A significant correlation between early postoperative scintigraphic results and biochemical parameters was demonstrated.
Kansoul
H A
HA
Division of Transplantation Surgery, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
Axelsson
R
R
Yamamoto
S
S
Savicheva
I
I
Aspelin
P
P
Ericzon
B-G
BG
Gjertsen
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D028227:Amyloid Neuropathies, Familial / Q000000981:diagnostic imaging; D000814:Aniline Compounds; D001219:Aspartate Aminotransferases / Q000097:blood; D001659:Biliary Tract / Q000000981:diagnostic imaging*; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D005998:Glycine; D006801:Humans; D007098:Imino Acids / Q000493:pharmacokinetics; D008099:Liver / Q000000981:diagnostic imaging*; D008107:Liver Diseases / Q000000981:diagnostic imaging* / Q000601:surgery; D008111:Liver Function Tests / Q000379:methods; D016031:Liver Transplantation / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D011184:Postoperative Period; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013995:Time
D000814:Aniline Compounds; D015415:Biomarkers; D007098:Imino Acids; D015609:Organotechnetium Compounds; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; C034837:technetium Tc 99m mebrofenin; D001663:Bilirubin; D005998:Glycine