title: Acellular dermal matrix as a membrane for guided tissue regeneration in the treatment of Class II furcation lesions: a histometric and clinical study in dogs.
abstract: BACKGROUND
  The purpose of this study was to evaluate acellular dermal matrix (ADM) as a membrane for guided tissue regeneration (GTR) in the treatment of mandibular Class II furcation lesions and to compare it to a bioabsorbable membrane.
  
  
  METHODS
  Class II furcation lesions were created surgically and chronified in six mongrel dogs on the buccal surfaces of mandibular third and fourth premolars, bilaterally. After 1 month, GTR was performed. Each side was assigned randomly to the control group (CGr: bioabsorbable membrane made of polyglycolic acid: trimethylene carbonate) or the test group (TGr: ADM as a membrane). Clinical measurements of the width and thickness of the keratinized tissue (WKT and TKT, respectively) were made before GTR. The dogs were sacrificed 12 weeks following GTR, and histomorphometric analysis was performed. Area measurements were taken of new tissue, epithelium, connective tissue, and new bone; bone height and new cementum were measured.
  
  
  RESULTS
  The formation of new bone, cementum, and periodontal ligament were similar in both groups. There were no statistically significant differences between the groups for any histomorphometric measurement. The TGr had a statistically significant increase in WKT and TKT after 3 months. The mean TKT gain was 1.03 mm for the TGr and 0.26 mm for the CGr (P <0.05).
  
  
  CONCLUSIONS
  The ADM demonstrated histomorphometric results similar to the bioabsorbable membrane and resulted in a greater increase in the thickness of the keratinized tissue.
authors.affiliation: Department of Bucco-Maxillo-Facial Surgery and Traumatology and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
authors.forename: Patrícia Freitas
authors.initials: PF
authors.lastname: de Andrade
authors.forename: Sérgio Luís Scombatti
authors.initials: SL
authors.lastname: de Souza
authors.forename: Guilherme
authors.initials: G
authors.lastname: de Oliveira Macedo
authors.forename: Arthur Belém
authors.initials: AB
authors.lastname: Novaes
authors.forename: Márcio Fernando
authors.initials: MF
authors.lastname: de Moraes Grisi
authors.forename: Mário
authors.initials: M
authors.lastname: Taba
authors.forename: Daniela Bazan
authors.initials: DB
authors.lastname: Palioto
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D004146:Dioxanes / Q000627:therapeutic use; D004285:Dogs; D017823:Furcation Defects / Q000473:pathology / Q000628:therapy*; D005881:Gingiva / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008334:Mandible; D008567:Membranes, Artificial; D011100:Polyglycolic Acid / Q000627:therapeutic use; D017768:Skin, Artificial
chemical_list: C440568:Alloderm; D001672:Biocompatible Materials; D004146:Dioxanes; D008567:Membranes, Artificial; D011100:Polyglycolic Acid; C443643:trimethylene carbonate; D003094:Collagen