Clinical experience in treatment of Amanita mushroom poisoning with Glossy Ganoderma Decoction and routine Western medicines.
OBJECTIVE
To assess the effects of treatment of Amanita mushroom poisoning with Glossy anoderma Decoction (, GGD).


METHODS
Twelve patients with acute Amanita mushroom poisoning received conventional treatment (penicillin and reduced glutathione) combined with oral administration of GGD (treated group), which was prepared out of 200 g Glossy ganoderma decocted in water to 600 mL, and 200 ml was given once, three times a day for 7 successive days; while conventional treatment alone was given to the other 11 patients assigned to the control group. The therapeutic efficacy and changes in serum levels of total bilirubin (TBil), bile acids (BA), alanine transaminase (ALT), and aspartate transaminase (AST) activities in the two groups were compared.


RESULTS
The cured-markedly effective rate in the treated group was more significant than that in the control group (P<0.01). Elevation in TBil, BA, ALT, and AST activities were observed in both groups 3 days after poisoning, which progressively increased thereafter in the control group. In the treated group, they reached their peak on the 3rd day and then declined gradually. The differences between pre-treatment and post-treatment in both groups were obviously significant (P<0.01), so were the differences between the two groups at corresponding time points (P<0.01).


CONCLUSIONS
GGD shows excellent clinical efficacy in the treatment of acute Amanita mushroom poisoning and can reduce mortality significantly.
Xiao
Gui-lin
GL
Xiangya Hospital Affiliated to Central South University, Changsha, 410008, China. xiaoguilinxy@126.com
Zhang
Chun-hu
CH
Liu
Fa-yi
FY
Chen
Zuo-hong
ZH
Hu
Sui-yu
SY
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000545:Amanita; D001647:Bile Acids and Salts / Q000097:blood; D002648:Child; D005260:Female; D032902:Ganoderma; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009145:Mushroom Poisoning / Q000097:blood / Q000188:drug therapy* / Q000401:mortality
D001647:Bile Acids and Salts