title: Natural history of right ventricular dysfunction after acute pulmonary embolism.
abstract: BACKGROUND
  Acute pulmonary embolism (PE) associated with right ventricular (RV) dysfunction has an adverse prognosis. We investigated individual parameters of RV dysfunction after acute PE, assessing their correlation with the PE extent and recovery during 6 months.
  
  
  METHODS
  In all, 35 patients (age 63 +/- 18 years) with acute PE were prospectively investigated for 6 months with serial echocardiography, incorporating longitudinal myocardial-velocity and strain imaging. The extent of PE was quantified on day 1 by ventilation/perfusion pulmonary scintigraphy with PE defined as large when there was greater than 30% lung involvement.
  
  
  RESULTS
  PE extent correlated strongly with a number of parameters of RV function, and the strongest univariate correlates were tricuspid annular motion (TAM) (r = -0.65, P < .0001) and the ratio of RV apical to RV basal systolic velocity (r = 0.66, P < .0001). Multivariate analysis identified TAM (P < .0001) and RV basal late-diastolic velocity (P = .01) as independently predicting PE extent, with a combined correlation (R2 = 0.52, P < .0001). A TAM of less than 2.0 cm had sensitivity, specificity, and positive- and negative-predictive values of 75%, 84%, 75%, and 79%, respectively, in predicting large PE. Prospective follow-up identified that RV:left ventricular end-diastolic area ratio returned to normal within 6 weeks, whereas TAM and ratio of RV apical to RV basal systolic velocity normalized after 3 to 6 months.
  
  
  CONCLUSIONS
  TAM and ratio of RV apical to RV basal systolic velocity are useful indicators of the extent of PE, and provide unique insights into the recovery of RV function after acute PE.
authors.affiliation: Department of Cardiology, Concord Repatriation General Hospital, ANZAC Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Tommy
authors.initials: T
authors.lastname: Chung
authors.forename: Louise
authors.initials: L
authors.lastname: Emmett
authors.forename: Robert
authors.initials: R
authors.lastname: Mansberg
authors.forename: Matthew
authors.initials: M
authors.lastname: Peters
authors.forename: Leonard
authors.initials: L
authors.lastname: Kritharides
mesh_terms: D000208:Acute Disease; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000150:complications* / Q000000981:diagnostic imaging*; D013318:Stroke Volume; D014463:Ultrasonography; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000209:etiology*; D016278:Ventricular Function, Right