The short PET in pediatrics.
BACKGROUND
The peritoneal equilibration test (PET) is a 4-hour procedure that is recommended to be performed in children receiving peritoneal dialysis to assist in prescription management. While a shortened version of the PET has been used in adults and reliably characterizes peritoneal membrane transport capacity, no similar experience with children has been reported.


METHODS
Retrospective evaluation of 2-hour and 4-hour PET data obtained from 20 children receiving chronic peritoneal dialysis in a single center. Characterization of membrane transport capacity was based on evaluation of serum and dialysate samples used to determine the dialysate-to-plasma ratio (D/P) of creatinine and the ratio of dialysate glucose to baseline dialysate glucose (D/D(0)). Patient values were compared to pediatric reference data.


RESULTS
In all 20 patients, characterization of peritoneal membrane transport capacity using 2-hour D/P and D/D(0) results was identical to that determined using 4-hour data for the same solute. While the creatinine- and glucose-based characterization was discrepant in 14 of 20 patients, in only 1 case was the discrepancy of more than a single transport category.


CONCLUSIONS
These results support the accuracy of a short PET in children, a procedure that should prove beneficial in terms of patient and staff time.
Warady
Bradley A
BA
Children's Mercy Hospitals and Clinics, Kansas City, Missouri 64108, USA. bwarady@cmh.edu
Jennings
Janelle
J
D000293:Adolescent; D001693:Biological Transport, Active / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D015314:Dialysis Solutions / Q000493:pharmacokinetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D008297:Male; D010530:Peritoneal Dialysis / Q000379:methods*; D010537:Peritoneum / Q000378:metabolism*; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors
D015314:Dialysis Solutions; D003404:Creatinine