Seroprevalence of neutralizing antibodies to adenovirus type 5 among children in India: implications for recombinant adenovirus-based vaccines.
We determined the levels of adenovirus 5 (Ad5) neutralizing antibodies in children in India less than 2 years of age. The results clearly show an age-dependent increase in Ad5-specific immunity, with 7- to 12-month-old children having the lowest levels of Ad5 immunity. This opens up the scope for the use of recombinant Ad5-based vaccines in this age group.
Appaiahgari
Mohan Babu
MB
National Institute of Immunology, Aruna saf Ali Marg, JNU Complex, New Delhi 110067, India.
Pandey
Ravindra Mohan
RM
Vrati
Sudhanshu
S
D000258:Adenovirus Infections, Human / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics / Q000276:immunology*; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood*; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D009500:Neutralization Tests; D012703:Serotyping; D014614:Vaccines, Synthetic; D014765:Viral Vaccines
D000914:Antibodies, Viral; D014614:Vaccines, Synthetic; D014765:Viral Vaccines