Fine-tuning of the innate immune response by microRNAs.
MicroRNAs (miRNAs) are emerging as potent regulators of many biological processes, including cellular differentiation and disease. Recently, miRNA has been directly involved in innate immunity and transduction signalling by Toll-like receptors and the ensuing cytokine response. In this review, we present an overview of what is currently known of the involvement of miRNA and RNA interference components in the fine-tuning of innate immune responses.
Gantier
Michael P
MP
Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.
Sadler
Anthony J
AJ
Williams
Bryan R G
BR
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics* / Q000276:immunology*; D035683:MicroRNAs / Q000235:genetics* / Q000276:immunology*; D034622:RNA Interference; D014777:Virus Diseases / Q000628:therapy; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; D035683:MicroRNAs