A survey of sex differences in 249 pemphigus patients and possible explanations.
BACKGROUND
Pemphigus, an immunoblistering disorder, is reported with equal or near equal frequencies in men and women despite prominent female predominance in prevalence ratios of the vast majority of autoimmune diseases.


OBJECTIVE
To assess a possible correlation between pemphigus and intake of sex hormones in a cohort of pemphigus patients.


METHODS
A prospective online survey using a specially designed questionnaire was conducted among patients with diagnosed pemphigus in the United States during a 1-year period from September 2005 through September 2006.


RESULTS
A total of 249 pemphigus cases were enrolled, 158 women (63%) and 91 men (36%). The female-to-male ratio was 1.7:1. Age at onset of the disease ranged from 16 to 85 years, mean 4.5.4+/-12.9 [corrected] years for both sexes (not statistically significant): 45.3 for women and 45.7 for men. At the time of pemphigus diagnosis, 12% (20 of 158) of the women and 4% (4 of 91) of the men reported using hormone replacement therapy. At the time of disease onset, 46% (20 of 43) of the postmenopausal women took hormone replacement therapy.


CONCLUSIONS
Possible questionnaire self-reporting biases.


CONCLUSIONS
The finding of a female predominance among pemphigus patients is attributed to the immunopathogenesis of the disease that makes women more susceptible to this and other autoimmune disorders and to the strikingly high proportion of hormone replacement therapy users found among postmenopausal women.
Brenner
Sarah
S
Department of Dermatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel. derma@tasmc.health.gov.il
Wohl
Yonit
Y
D017668:Age of Onset; D001327:Autoimmune Diseases / Q000139:chemically induced; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000139:chemically induced* / Q000453:epidemiology; D012307:Risk Factors; D012737:Sex Factors; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology