title: [Immunoglobulin D lambda multiple myeloma: a case report].
abstract: To improve the recognition of immunoglobulin D multiple myeloma and explore its clinical feature and laboratory examination characteristics, so as to reduce the the missed diagnosis and misdiagnosis, a case of IgD multiple myeloma (MM) with myelofibrosis and bone marrow necrosis is reported. The clinical feature, treatment and prognosis of IgDlambda MM were discussed. Immunoglobulin D multiple myeloma is a rare disease and predominantly occurs in young male patients, which shows an aggressive clinical course with poor response to conventional treatment and unfavorable prognosis. Immunoglobulin D multiple myeloma was usually misdiagnosed as a light chain type multiple myeloma by using routine laboratory examination. Immunoglobulin D monoclonal protein is not easy to be detected owing to its low protein level, resulting in missed diagnosis. Immunofixation electrophoresis is highly sensitive and specific for diagnosis of IgD MM, can enhance accuracy of diagnosis for this rare disease.
authors.affiliation: Department of Hematology, The Second Hospital, Hebei Medical University, Shijiazhuang 050000, China. qiaoshukai@yahoo.com.cn
authors.forename: Shu-Kai
authors.initials: SK
authors.lastname: Qiao
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Fu-Xu
authors.initials: FX
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Pan
authors.forename: Li
authors.initials: L
authors.lastname: Yao
authors.forename: Zuo-Ren
authors.initials: ZR
authors.lastname: Dong
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D007072:Immunoglobulin D / Q000097:blood*; D007146:Immunoglobulin lambda-Chains / Q000097:blood*; D008297:Male; D009101:Multiple Myeloma / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D055728:Primary Myelofibrosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis
chemical_list: D007072:Immunoglobulin D; D007146:Immunoglobulin lambda-Chains