Medium term follow-up of a randomized controlled trial of interventions for young people at ultra high risk of psychosis.
Valid criteria to identify young people who are believed to be at ultra high risk (UHR) of developing a psychotic episode were developed over the last decade. The first randomized controlled trial of treatment in a UHR cohort indicated that specific pharmacotherapy and psychotherapy delayed onset of disorder, and possibly reduced incidence. This paper reports results of follow-up of that trial. 41 of the 59 (69.5%) participants in the original study agreed to follow-up. No differences were found in transition rate, level of symptomatology or functioning between participants who received a combination of psychological treatment and anti-psychotic medication compared to those who received supportive therapy alone. A significant proportion of both treatment groups reported moderate levels of psychiatric morbidity and a continuing need and desire for care at this follow-up. Low levels of hospitalisation were noted for those who did progress to psychosis. Conclusions that can be drawn from this exploratory study are limited by the relatively small number of participants in the original study and the failure to follow-up the entire cohort. Although participants may have been treated too briefly to result in enduring positive effects, there appear to have been some cost savings in inpatient mental health treatment required after the end of the trial for individuals in both treatment groups who developed psychosis.
Phillips
Lisa J
LJ
Department of Psychology, University of Melbourne, VIC, 3010 Australia. lisajp@unimelb.edu.au
McGorry
Patrick D
PD
Yuen
Hok Pan
HP
Ward
Janine
J
Donovan
Kerri
K
Kelly
Daniel
D
Francey
Shona M
SM
Yung
Alison R
AR
D000293:Adolescent; D000328:Adult; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007407:Interviews as Topic; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000453:epidemiology / Q000517:prevention & control*; D012307:Risk Factors; D013997:Time Factors