title: The clinical, haematological and morphological profile of patients with myelodysplastic syndromes: a single institution experience from Turkey.
abstract: In a retrospective analysis of 113 patients with primary myelodysplastic syndromes (MDS) diagnosed according to French-American-British (FAB) classification, we evaluated the prognostic impact of FAB and World Health Organisation (WHO) classifications, International Prognostic Scoring System (IPSS), and other clinical and laboratory variables. The median age was 69. IPSS could be applied to 75 patients classified according to the FAB criteria and to 50 patients reclassified according to the WHO criteria. At a median follow-up of 24 months, 22 patients (19.5 %) transformed to acute myelogenous leukaemia (AML). Overall survival (OS) of patients differed significantly between the FAB and WHO subgroups (p < 0.0001). In WHO classification, significant differences were observed in both OS and leukaemia free survival (LFS) between patients with RA/RARS and refractory cytopenia with multi-lineage dysplasia/refractory cytopenia with multi-lineage dysplasia and ringed sideroblasts (RCMD/RS-RCMD) (p = 0.0001). High-risk according to IPSS score and blood transfusion need were significantly predictive for a shorter survival and higher risk of transformation. Hemoglobin <10 g/dl, neutrophil count <0.5 x 10(9)/L, platelet count <50 x 10(9)/L had an unfavourable prognostic impact on survival in multi-variate analysis. Our conclusions support the previous findings on the value of WHO classification for prediction of prognosis in MDS.
authors.affiliation: Division of Hematology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. fatih.demirkan@deu.edu.tr
authors.forename: Fatih
authors.initials: F
authors.lastname: Demirkan
authors.forename: Inci
authors.initials: I
authors.lastname: Alacacioglu
authors.forename: Ozden
authors.initials: O
authors.lastname: Piskin
authors.forename: Hayri G
authors.initials: HG
authors.lastname: Ozsan
authors.forename: Baris
authors.initials: B
authors.lastname: Akinci
authors.forename: Ali M
authors.initials: AM
authors.lastname: Ozcan
authors.forename: Tugba
authors.initials: T
authors.lastname: Yavuzsen
authors.forename: Erdinc
authors.initials: E
authors.lastname: Yuksel
authors.forename: Bulent
authors.initials: B
authors.lastname: Undar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic; D002965:Classification; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000145:classification / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D014421:Turkey / Q000453:epidemiology; D014944:World Health Organization