Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs.
Second-generation carnosine analogs bearing the histidyl-hydrazide moiety have been synthesized and tested for their efficiency in scavenging malondialdehyde (MDA) derived from lipid peroxidation and for their ability to reverse the glycation process in the glucose-ethylamine Schiff base model. The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress.
Guiotto
Andrea
A
Institute of Biomolecular Chemistry of CNR, Department of Chemical Sciences, University of Padua, Via F. Marzolo, 1-35131 Padova, Italy. andrea.guito@unipd.it
Ruzza
Paolo
P
Babizhayev
Mark A
MA
Calderan
Andrea
A
D001205:Ascorbic Acid / Q000378:metabolism; D002336:Carnosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006031:Glycosylation; D006639:Histidine / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D007501:Iron / Q000378:metabolism; D015227:Lipid Peroxidation; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy; D008315:Malondialdehyde / Q000737:chemistry* / Q000378:metabolism; D018384:Oxidative Stress; D012545:Schiff Bases; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D006834:Hydrazines; D008081:Liposomes; D012545:Schiff Bases; D017392:Thiobarbituric Acid Reactive Substances; C029424:hydrazine; D006639:Histidine; D008315:Malondialdehyde; D002336:Carnosine; D007501:Iron; D001205:Ascorbic Acid