title: [New concepts on the pathogenesis of chronic Chagas cardiomyopathy: myocardial gene and protein expression profiles].
abstract: The pathogenesis of chronic Chagas cardiomyopathy (CCC) is still being unraveled. In the last decade, a role for inflammatory cytokines on tissue damage has been shown. The present review will address the molecular and immunological mechanisms of tissue damage on human CCC with a special focus on results obtained by our research group using genomic and proteomic approaches. The results suggest that direct modulation of myocardium gene and protein expression by inflammatory cytokines may be a new pathogenic mechanism in CCC, with therapeutic implications.
authors.affiliation: Instituto do Coração, Universidade de São Paulo, São Paulo, Brasil. edecunha@gmail.com
authors.forename: Edecio
authors.initials: E
authors.lastname: Cunha-Neto
authors.forename: Priscila C
authors.initials: PC
authors.lastname: Teixeira
authors.forename: Luciana G
authors.initials: LG
authors.lastname: Nogueira
authors.forename: Charles
authors.initials: C
authors.lastname: Mady
authors.forename: Barbara
authors.initials: B
authors.lastname: Lanni
authors.forename: Noedir
authors.initials: N
authors.lastname: Stolf
authors.forename: Alfredo
authors.initials: A
authors.lastname: Fiorelli
authors.forename: Ronaldo
authors.initials: R
authors.lastname: Honorato
authors.forename: Jorge
authors.initials: J
authors.lastname: Kalil
mesh_terms: D000818:Animals; D002598:Chagas Cardiomyopathy / Q000235:genetics / Q000276:immunology; D002908:Chronic Disease; D016207:Cytokines / Q000276:immunology*; D020869:Gene Expression Profiling; D006801:Humans; D007249:Inflammation / Q000276:immunology; D040901:Proteomics
chemical_list: D016207:Cytokines