[Management of head and neck cancer].
When diagnosed at a locally advanced stage head-and-neck carcinomas require a multidisciplinary management. Primary surgery should be followed by the concomitant delivery of adjuvant radio- and chemotherapy, which is nowadays considered as the standard approach. A number of operable cases can be treated according to organ preservation programmes as well. Unresectable disease, the prognosis of which remains dismal, is typically treated with chemo-radiation too, but with the advent of taxanes, induction chemotherapy is currently revisited. Novel targeted therapies yielded encouraging results, when combined with irradiation, because of lower toxicity index than chemotherapy.
Bernier
J
J
Service de radio-oncologie, Clinique de Genolier, 1272 Genolier. jbernier@genolier.net
D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans