title: Infant anaplastic lymphoma: case report and review of the literature.
abstract: Anaplastic large cell lymphoma (ALCL) is a well-known entity, but there are no data on prognosis according to the age of the patient, especially in infants. A 2-month-old girl was admitted with a 2-week history of coughing, fever, and lymphadenopathy. Physical examination revealed mild respiratory distress, an erythematous macular rash on her trunk, massive cervical lymphadenopathy, splenomegaly, and very mild ascites. Chest radiograph showed bilateral pulmonary infiltrates, pleural effusion, and a mediastinal mass. CBC count showed WBC: 172,000/microL (PMN 40%, lymphocytes 47%, monocytes 3%); hemoglobin concentration: 8.7 g/dL; platelets: 390,000/microL. Cervical lymph node biopsy revealed anaplastic lymphoma with positive staining to ALK 1 and TIA 1. Immunophenotypic analysis of peripheral and bone marrow lymphoid cells showed an aberrant T-cell immunophenotype, including expression of CD3, CD45R0+, CD43+, and CD30+. Cytogenetic analysis performed on blood and bone marrow samples demonstrated the translocation t(2;5) (p23;q35), and trisomy 47. After leucophoresis, the child received chemotherapy according to the ALCL-99-EICNHL protocol, and was started on corticosteroids and cyclophosphamide, which resulted in marked improvement. After the second course, WBC decreased to 6000/microL without tumor lysis syndrome, but the child developed bacterial and fungal disseminated infections and died of septic shock with multiorgan failure. This report is of a rare case of infant anaplastic lymphoma and excellent response to treatment. Unfortunately, she did succumb to overwhelming infection. More reports of similar cases may determine the cause and prognosis of such children, helping to tailor therapy according to the age of the child and other prognostic factors, especially bone marrow involvement.
authors.affiliation: Department of Pediatric Hematology-Oncology, Meyer Children's Hospital, Rambam Medical Center, Haifa, Israel.
authors.forename: Ayelet
authors.initials: A
authors.lastname: Ben Barak
authors.forename: Ronit
authors.initials: R
authors.lastname: Elhasid
authors.forename: Ofer
authors.initials: O
authors.lastname: Ben Itzhak
authors.forename: Yehudit
authors.initials: Y
authors.lastname: Ben Arieh
authors.forename: Irena
authors.initials: I
authors.lastname: Zaidman
authors.forename: Motti
authors.initials: M
authors.lastname: Haimi
authors.forename: Gad
authors.initials: G
authors.lastname: Bar-Joseph
authors.forename: Myriam Weyl
authors.initials: MW
authors.lastname: Ben Arush
mesh_terms: D001424:Bacterial Infections / Q000139:chemically induced; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D009102:Multiple Organ Failure; D009181:Mycoses / Q000139:chemically induced; D012074:Remission Induction; D012772:Shock, Septic