Stereoselective formal total synthesis of (+)-methynolide.
A highly stereoselective and convergent formal total synthesis of (+)-methynolide is described. The salient features of this synthesis have been the construction of the C1-C7 and C8-C11fragments via a desymmetrization approach, Sharpless asymmetric epoxidation of an allyl alcohol, respectively, and linkage of both the fragments by Nozaki-Hiyama-Kishi reaction.
Yadav
J S
JS
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. yadavpub@iict.res.in
Pratap
T V
TV
Rajender
V
V
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D018942:Macrolides / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D018942:Macrolides; C522940:methynolide