Pathways of clathrin-independent endocytosis.
There are numerous ways that endocytic cargo molecules may be internalized from the surface of eukaryotic cells. In addition to the classical clathrin-dependent mechanism of endocytosis, several pathways that do not use a clathrin coat are emerging. These pathways transport a diverse array of cargoes and are sometimes hijacked by bacteria and viruses to gain access to the host cell. Here, we review our current understanding of various clathrin-independent mechanisms of endocytosis and propose a classification scheme to help organize the data in this complex and evolving field.
Mayor
Satyajit
S
National Centre for Biological Sciences, UAS-GKVK Campus, Bangalore 560065, India. mayor@ncbs.res.in
Pagano
Richard E
RE
D000818:Animals; D001419:Bacteria / Q000378:metabolism / Q000648:ultrastructure; D001693:Biological Transport, Active; D002966:Clathrin; D004705:Endocytosis; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000382:microbiology / Q000648:ultrastructure / Q000821:virology; D006801:Humans; D053586:Virus Internalization; D014780:Viruses / Q000378:metabolism / Q000648:ultrastructure
D002966:Clathrin