title: Treatment of ocular surface syndrome after LASIK with autologous platelet-rich plasma.
abstract: OBJECTIVE
  To ascertain the usefulness of platelet-rich plasma in the treatment of patients suffering from symptomatic ocular surface syndrome following LASIK.
  
  
  METHODS
  Twenty-six eyes (9 women and 4 men) affected by symptomatic ocular surface syndrome were treated with topical eye drops of autologous platelet-rich plasma and results were reported at 4 weeks. Topical platelet-rich plasma was prepared from total blood and enriched in platelets by centrifugation.
  
  
  RESULTS
  Eighty-five percent of patients experienced significant improvement of symptoms; best spectacle-corrected visual acuity increased 1 to 2 lines in 54%; fluorescein staining analysis showed a 69% full fluorescein disappearance; and tear break-up time increased > 2 seconds in 46%. Only one patient developed intolerance to platelet-rich plasma after 4 weeks.
  
  
  CONCLUSIONS
  Autologous platelet-rich plasma was effective in the treatment of patients with ocular surface syndrome following LASIK, with symptoms generally relieved and a positive effect on punctate keratitis.
authors.affiliation: Department of Cornea and Refractive Surgery, VISSUM Instituto Oftalmológico de Alicante, Spain. rdioa@vissum.com
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Alio
authors.forename: Silvia
authors.initials: S
authors.lastname: Pastor
authors.forename: Jose
authors.initials: J
authors.lastname: Ruiz-Colecha
authors.forename: Alejandra
authors.initials: A
authors.lastname: Rodriguez
authors.forename: Alberto
authors.initials: A
authors.lastname: Artola
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003316:Corneal Diseases / Q000209:etiology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D010865:Pilot Projects; D053657:Platelet-Rich Plasma; D014792:Visual Acuity; D014945:Wound Healing
chemical_list: D009883:Ophthalmic Solutions