title: Impact of air pollution on hospital admissions in Southwestern Ontario, Canada: generating hypotheses in sentinel high-exposure places.
abstract: BACKGROUND
  Southwestern Ontario (SWO) in Canada has been known as a 'hot spot' in terms of environmental exposure and potential effects. We chose to study 3 major cities in SWO in this paper. We compared age-standardized hospital admission ratios of Sarnia and Windsor to London, and to generate hypotheses about potential pollutant-induced health effects in the 'Chemical Valley', Sarnia.
  
  
  METHODS
  The number of daily hospital admissions was obtained from all hospitals in London, Windsor and Sarnia from January 1, 1996 to December 31, 2000. We used indirect age adjustment method to obtain standardized admissions ratios for males and females and we chose London as the reference population. This process of adjustment was to apply the age-specific admission rates of London to the population of Sarnia and Windsor in order to yield expected admissions. The observed number of admissions was then compared to the expected admissions in terms of a ratio. These standardized admissions ratios and their corresponding confidence intervals were calculated for Sarnia and Windsor.
  
  
  RESULTS
  Our findings showed that Sarnia and Windsor had significantly higher age-adjusted hospital admissions rates compared to London. This finding was true for all admissions, and especially pronounced for cardiovascular and respiratory admissions. For example, in 1996, the observed number of admissions in Sarnia was 3.11 (CI: 2.80, 3.44) times for females and 2.83 (CI: 2.54, 3.14) times for males as would be expected by using London's admission rates.
  
  
  CONCLUSIONS
  Since hospital admissions rates were significantly higher in 'Chemical Valley' as compared to both London and Windsor, we hypothesize that these higher rates are pollution related. A critical look at the way ambient air quality and other pollutants are monitored in this area is warranted. Further epidemiological research is needed to verify our preliminary indications of harmful effects in people living in 'Chemical Valley'.
authors.affiliation: Department of Mathematics & Statistics, University of Windsor, Windsor, Ontario, Canada. kfung@uwindsor.ca
authors.forename: Karen Y
authors.initials: KY
authors.lastname: Fung
authors.forename: Isaac N
authors.initials: IN
authors.lastname: Luginaah
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Gorey
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D000397:Air Pollution / Q000009:adverse effects / Q000032:analysis / Q000706:statistics & numerical data*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002617:Chemical Industry / Q000706:statistics & numerical data; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis / Q000706:statistics & numerical data; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D012140:Respiratory Tract Diseases / Q000453:epidemiology; D018571:Sentinel Surveillance; D017678:Sex Distribution; D014504:Urban Health / Q000706:statistics & numerical data*
chemical_list: D000393:Air Pollutants