title: Relationship between interleukin-8 and the oxidant-antioxidant system in end-stage renal failure patients.
abstract: OBJECTIVE
  We aimed to evaluate the relationship between interleukin-8 and the oxidant-antioxidant system in end-stage renal failure patients with and without diabetes mellitus undergoing regular hemodialysis treatment.
  
  
  METHODS
  Plasma levels of malondialdehyde and whole blood reduced glutathione were measured as markers of the oxidant and antioxidant systems, respectively. Plasma interleukin-8 levels were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  When compared with controls, plasma interleukin-8 levels were elevated in both diabetic and nondiabetic end-stage renal disease patients. Plasma malondialdehyde levels were statistically significantly higher in end-stage renal disease patients with and without diabetes mellitus than they were in controls; however, reduced glutathione levels were statistically significantly lower in diabetic and nondiabetic end-stage renal disease patients than they were controls.
  
  
  CONCLUSIONS
  In end-stage renal disease patients with and without diabetes mellitus, elevated interleukin- 8 levels and decreased reduced glutathione levels may be attributed to increased oxidative stress due to inflammation. In other words, increased reactive oxygen species may induce interleukin-8 production and result in diminished reduced glutathione levels. Our data suggest a relationship between interleukin- 8 and the oxidant-antioxidant system in end-stage renal failure patients.
authors.affiliation: Department of Neuroscience, Istanbul University, Institute for Experimental Medicine, Istanbul, Turkey. aydinm@istanbul.edu.tr
authors.forename: Makbule
authors.initials: M
authors.lastname: Aydin
authors.forename: Elif
authors.initials: E
authors.lastname: Ozkok
authors.forename: Oguz
authors.initials: O
authors.lastname: Ozturk
authors.forename: Bedia
authors.initials: B
authors.lastname: Agachan
authors.forename: Hulya
authors.initials: H
authors.lastname: Yilmaz
authors.forename: Ilhan
authors.initials: I
authors.lastname: Yaylim
authors.forename: Seher
authors.initials: S
authors.lastname: Kebabcioglu
authors.forename: Turgay
authors.initials: T
authors.lastname: Ispir
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D016209:Interleukin-8; D016877:Oxidants; D008315:Malondialdehyde; D005978:Glutathione