title: Emerging minimal-change nephrotic syndrome in a patient with chronic mesangial proliferative lupus nephritis.
abstract: A 41-year-old Japanese woman with a 25-year history of systemic lupus erythematosus was admitted because of abrupt onset of nephrotic syndrome and acute renal failure. Renal biopsy specimen showed only mild mesangial proliferative glomerulonephritis associated with mesangial deposition of immunoglobulins/complements. No significant immune deposits were found in the glomerular capillary walls, but mild foot process effacement was observed on electron microscopy. Further, two-month corticosteroid therapy improved her massive proteinuria and renal dysfunction, indicating that this patient showed minimal-change nephropathy superimposed on mesangial proliferative lupus nephritis.
authors.affiliation: Department of Internal Medicine, Shiga University of Medical Science, Otsu.
authors.forename: Naoko
authors.initials: N
authors.lastname: Deji
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Masami
authors.initials: M
authors.lastname: Kanasaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Aoyama
authors.forename: Yuki
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Nishio
authors.forename: Takashi
authors.initials: T
authors.lastname: Uzu
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kashiwagi
mesh_terms: D000208:Acute Disease; D000328:Adult; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D005260:Female; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D007677:Kidney Function Tests; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008181:Lupus Nephritis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D009402:Nephrosis, Lipoid / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D012720:Severity of Illness Index