End-stage disease of native kidneys in a patient with biopsy-proven Arndt-Gottron scleromyxoedema and recurrence in the transplanted kidney.
End-stage renal disease-stage 5 chronic kidney disease (CKD)-of the native kidneys, related to biopsy-proven Arndt-Gottron scleromyxoedema, developed in a male patient. From 1998 until 2001, the patient was treated by haemodialysis. In June 2001, cadaveric kidney transplantation was performed. In January 2004, a kidney biopsy was performed because of deteriorating renal function revealing relapse of scleromyxoedema with typical concentric narrowing of the arterioles due to accumulation of mucopolysaccharides with severe glomerular ischaemia. Arndt-Gottron scleromyxoedema is an as yet unsuspected cause of stage 5 CKD of the native kidneys. Moreover, the disease can relapse in the transplanted kidney, again leading to intractable transplant stage 5 CKD.
Peeters
Patrick
P
Renal Unit, Department of Internal Medicine, University Hospital UZ Gent 0K12 IA, De Pintelaan 185, 9000 Gent, Belgium. p.peeters@ugent.be
Praet
Marleen
M
Van Vlem
Bruno
B
Naeyaert
Jean-Marie
JM
Vanholder
Raymond
R
D001706:Biopsy; D004487:Edema / Q000150:complications / Q000473:pathology*; D005355:Fibrosis; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism; D012008:Recurrence; D053718:Scleromyxedema / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D012867:Skin / Q000378:metabolism
D009077:Mucins