A clinical score predicting a brief and uneventful course of newly diagnosed idiopathic thrombocytopenic purpura in children.
The Nordic idiopathic thrombocytopenic purpura study data showed that morbidity occurred mainly in children with thrombocytopenia lasting >3 months, whereas, the risk period with platelet counts <20 x 10(9)/l was short and the number of bleeding events low in children with shorter disease duration. These brief, uneventful courses were predicted by developing a scoring system based on six clinical features: abrupt onset (weight 5), age <10 years (3), preceding infection (2), platelet count <5 x 10(9)/l, wet purpura (1) and male gender (1). The score was derived and validated in two different cohorts of children. High scores (10-14) clearly identified low-risk patients. The score provides valid prognostic information and may be useful in clinical decision-making.
Edslev
Pernille Wendtland
PW
Department of Paediatrics, Aalborg Hospital, Aalborg, Denmark.
Rosthøj
Steen
S
Treutiger
Iris
I
Rajantie
Jukka
J
Zeller
Bernward
B
Jonsson
Olafur G
OG
D000367:Age Factors; D002648:Child; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D016756:Immunoglobulins, Intravenous; D008297:Male; D016017:Odds Ratio; D010976:Platelet Count; D011379:Prognosis; D011446:Prospective Studies; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood*; D018570:Risk Assessment / Q000379:methods; D012737:Sex Factors
D016756:Immunoglobulins, Intravenous