title: Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy.
abstract: Expression of glomerular epithelial protein 1 (GLEPP1), a receptor tyrosine phosphatase present on the apical cell surface of the glomerular podocyte, and podocyte morphology were investigated in renal specimens from 51 patients with biopsy-diagnosed immunoglobulin A nephropathy (IgAN) and 11 controls. Clinical parameters, such as daily proteinuria were obtained from the patients' records and pathological manifestations of IgAN in the specimens were graded. GLEPP1 was strongly expressed and diffusely distributed in the glomeruli of control specimens. GLEPP1 expression was reduced in IgAN, especially in patients with nephrotic proteinuria and severe pathological manifestations. Podocyte injury was evident in IgAN and was associated with lower GLEPP1 expression and higher pathological grade. GLEPP1 expression was also significantly associated with clinical parameters. The results of this study suggest that GLEPP1 expression may be a useful marker of podocyte injury in IgAN, and may be predictive of clinical and pathological severity.
authors.affiliation: Kidney Disease Centre, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Tian
authors.forename: H Ping
authors.initials: HP
authors.lastname: Wang
authors.forename: Y Ying
authors.initials: YY
authors.lastname: Mao
authors.forename: J
authors.initials: J
authors.lastname: Jin
authors.forename: J Hua
authors.initials: JH
authors.lastname: Chen
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D005922:Glomerulonephritis, IGA / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008565:Membrane Proteins / Q000378:metabolism*; D050199:Podocytes / Q000473:pathology*; D011237:Predictive Value of Tests; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3; D012016:Reference Values
chemical_list: D015415:Biomarkers; D008565:Membrane Proteins; C516888:PTPRO protein, human; D017027:Protein Tyrosine Phosphatases; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3