[Animal models of injury and repair in developing brain].
Animal models of injury and repair in developing brain. Brain injury is a major contributor to neonatal morbidity and mortality, a considerable group of these children will develop long term neurological sequels. Despite the great clinical and social significance and the advances in neonatal medicine, no therapy yet does exist that prevent or decrease detrimental effects in cases of neonatal brain injury. Our objective was to review recent research in relation to the hypothesis for repair mechanism in the developing brain, based in animal models that show developmental compensatory mechanisms that promote neural and functional plasticity. A better understanding of these adaptive mechanisms will help clinicians to apply knowledge derived from animals to human clinical situations.
Cuestas
Eduardo
E
Servicio de Pediatría y Neonatología, Hospital Privado, Córdoba. ecuestas@hospitalprivadosa.com.ar
Caceres
Alfredo
A
Palacio
Santiago
S
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development* / Q000503:physiopathology; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D009474:Neurons / Q000473:pathology / Q000502:physiology; D012377:Rodentia