Tuberculosis in acute leukemia: a clinico-hematological profile.
We studied 130 consecutive cases of acute leukemia over a 2-year period and identified 9 cases (6.9%) with active tuberculosis (TB). Eight patients with TB had acute myeloid leukemia (AML). Patients with AML were more likely to develop TB as compared to patients with acute lymphoblastic leukemia (ALL) despite the wider use of steroids and radiotherapy in ALL protocols {OR 4.41 (CI 0.53-36.44)}. Only 1 patient died of disseminated TB during post induction neutropenia. All other patients were successfully managed using current anti-tuberculous therapy (ATT). On the whole, TB did not cause any undue delay in chemotherapy and did not flare up during subsequent chemotherapy cycles. However it is not a commonly described infection in acute leukemia and a high index of suspicion is warranted especially in areas endemic for TB.
Mishra
Pravas
P
Department of Hematology, AIIMS, New Delhi, India.
Kumar
Rajat
R
Mahapatra
Manoranjan
M
Sharma
Sanjay
S
Dixit
Ashish
A
Chaterjee
Tathagat
T
Choudhry
D R
DR
Saxena
Renu
R
Choudhry
V P
VP
D000208:Acute Disease; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D007951:Leukemia, Myeloid; D008297:Male; D009503:Neutropenia; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*
D000995:Antitubercular Agents