Synthesis of four natural prenylflavonoids and their estrogen-like activities.
Four prenylflavonoids, bavachin 1, isobavachin 2, 7,4'-dihydroxy-8-prenylflavone 3, and 8-prenylapigenin 4 were synthesized and recognized for possessing estrogen-like activity in MCF-7/BOS cells, as evaluated by an estrogen-screening assay. All compounds significantly stimulated the proliferation of MCF-7/BOS cells in a dose-dependent manner. Isobavachin 2 showed the most potent activity, while bavachin 1 was the weakest. The estrogenic potency of these compounds is ranked as follows: 2 > 4 > 3 > 1.
Dong
Xiaowu
X
ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Fan
Yongjian
Y
Yu
Lingjun
L
Hu
Yongzhou
Y
D045744:Cell Line, Tumor; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D048789:Phytoestrogens / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D005419:Flavonoids; D048789:Phytoestrogens