title: Corneal wavefront-guided ablation with the Schwind ESIRIS laser for myopia.
abstract: OBJECTIVE
  To evaluate the outcome of corneal wavefront-guided LASIK for the treatment of myopia and myopic astigmatism.
  
  
  METHODS
  This study included 56 myopic virgin eyes of 28 patients with a mean spherical equivalent refraction of -4.40 +/- 1.83 diopters (D) (range: -1.25 to -9.75 D) and astigmatism < 2.50 D. The corneal wavefront aberrations were analyzed using a corneal topography system. The preoperative corneal wavefront aberration data obtained from the above analyses combined with manifest refraction were used to generate a customized ablation profile. The safety, efficacy, and predictability of the correction, contrast sensitivity, and corneal higher order wavefront aberrations were evaluated.
  
  
  RESULTS
  At 1-year follow-up, the mean residual spherical equivalent refractive error was -0.15 +/- 0.3 D (range: 0 to -1.25 D) and mean cylinder was -0.54 +/- 0.34 D (range: 0 to -1.50 D). Ninety-five percent of eyes were in the residual refractive error range of +/- 0.50 D and uncorrected visual acuity improved by 1.00 D or better in 94% of eyes. The safety index and efficacy index were 1.13 and 0.92, respectively. After treatment, corneal higher order wavefront aberrations with a 6-mm pupil diameter increased significantly (paired sample t test, P < .01), and contrast sensitivity with glare had small reductions at high spatial frequencies. Changes in spherical-like aberration (R = 0.708, P < .001) and higher order wavefront aberration (R = 0.449, P = .001), except for coma-like aberration (P = .238), were positively correlated with the amount of achieved correction.
  
  
  CONCLUSIONS
  Evaluation of clinical results showed that corneal wavefront-guided LASIK for the correction of myopia and myopic astigmatism was safe and effective. There was an increase in all higher order aberrations postoperatively.
authors.affiliation: Laboratory of Ophthalmology & Visual Optics, Institute for Laser Medicine and Bio-Photonics, Department of Biomedical Engineering, College of Life Science and Technology, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Chuanqing
authors.initials: C
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Jin
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Wang
authors.forename: Qiushi
authors.initials: Q
authors.lastname: Ren
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000503:physiopathology / Q000601:surgery*; D015350:Contrast Sensitivity / Q000502:physiology; D003315:Cornea / Q000503:physiopathology / Q000601:surgery*; D019781:Corneal Topography; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000295:instrumentation / Q000379:methods*; D008297:Male; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D012029:Refraction, Ocular / Q000502:physiology; D016896:Treatment Outcome