title: Relationship between obstructive sleep apnea and liver abnormalities in morbidly obese patients: a prospective study.
abstract: BACKGROUND
  Morbid obesity is a risk factor of nonalcoholic steatohepatitis (NASH). Obstructive sleep apnea (OSA) could also be an independent risk factor for elevated liver enzymes and NASH. The relationships between liver injuries and OSA in morbidly obese patients requiring bariatric surgery were studied prospectively.
  
  
  METHODS
  Every consecutive morbidly obese patient (BMI > or =40 kg/m2 or > or =35 kg/m2 with severe comorbidities) requiring bariatric surgery was included between January 2003 and October 2004. Polygraphic recording, serum aminotransferases (ALT, AST), gamma-glutamyltransferase (GGT) and liver biopsy were systematically performed. OSA was present when the apnea-hypopnea index (AHI) was >10/h.
  
  
  RESULTS
  62 patients (54 F; age 38.5 +/- 11.0 (SD) yrs; BMI 47.8 +/- 8.4 kg/m2) were included. Liver enzymes (AST, ALT or GGT) were increased in 46.6%. NASH was present in 34.4% and OSA in 84.7%. Patients with OSA were significantly older (P = 0.015) and had a higher BMI (P = 0.003). In multivariate analysis, risk factors for elevated liver enzymes were the presence of OSA and male sex. The presence of NASH was similar in patients with or without OSA (32.7% vs 44.4% of patients, P = 0.76).
  
  
  CONCLUSIONS
  In this cohort of morbidly obese patients requiring bariatric surgery, one-third of patients had NASH, a prevalence similar to previous studies. OSA was found to be a risk factor for elevated liver enzymes but not for NASH.
authors.affiliation: Service d'Hépato-Gastroentérologie, AP-HP Hôpital Louis Mourier, Colombes, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Jouët
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Sabaté
authors.forename: Dominique
authors.initials: D
authors.lastname: Maillard
authors.forename: Simon
authors.initials: S
authors.lastname: Msika
authors.forename: Charlotte
authors.initials: C
authors.lastname: Mechler
authors.forename: Séverine
authors.initials: S
authors.lastname: Ledoux
authors.forename: Florence
authors.initials: F
authors.lastname: Harnois
authors.forename: Benoit
authors.initials: B
authors.lastname: Coffin
mesh_terms: D000293:Adolescent; D000328:Adult; D050110:Bariatric Surgery; D016022:Case-Control Studies; D005234:Fatty Liver / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications* / Q000201:enzymology / Q000473:pathology; D011446:Prospective Studies; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000201:enzymology* / Q000473:pathology*; D000637:Transaminases / Q000097:blood*
chemical_list: D000637:Transaminases