Hirudin--the long and stony way from an anticoagulant peptide in the saliva of medicinal leech to a recombinant drug and beyond. A historical piece.
Nowak
Götz
G
Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum Düsseldorf, Universitätsstr. 1, Geb. 22.21, D-40225 Düsseldorf, Germany.
Schrör
Karsten
K
D000818:Animals; D000925:Anticoagulants; D024764:Hirudin Therapy; D006629:Hirudins / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics; D006801:Humans; D007865:Leeches; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use; D011994:Recombinant Proteins
D000925:Anticoagulants; D006629:Hirudins; D010455:Peptides; D011994:Recombinant Proteins