title: Synthesis and antimicrobial activities of silver(I) sulfanylcarboxylates. Structural isomers with identically or unequally coordinated Ag centers in an Ag4S4 ring.
abstract: We have investigated the reactions of silver nitrate and 3-(aryl)-2-sulfanylpropenoic acids [H(2)xspa, x: p = 3-phenyl-, f = 3-(2-furyl)-, t = 3-(2-thienyl)-, py = 3-(2-pyridyl)-] and 2-cyclopentylidene-2-sulfanylacetic acid (H(2)L) in 1 : 1 and 2 : 1 molar ratios. The 1 : 1 molar ratio gave compounds of type [Ag(HL)]; reaction of these compounds with diisopropylamine and NaOH gave [HQ][Ag(L)] (HQ = diisopropylammonium) and Na[Ag(L)] x H(2)O, respectively. These compounds, as well as those of type [Ag(2)(L)] obtained with the 1 : 2 molar ratio, were isolated and characterized by IR and NMR ((1)H and (13)C) spectroscopy. (109)Ag NMR spectroscopy and ESI-MS spectrometry were also used in some cases. The crystal structures of [HQ][Ag(pspa)] (11), in which the presence of structural isomers was detected, and [HQ][Ag(cpa)] (15) were determined by X-ray diffractometry. The antimicrobial activity of the complexes against E. coli, S. aureus, B. subtilis, P. aeruginosa/Resistant P. aeruginosa, and C. albicans was tested.
authors.affiliation: Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Barreiro
authors.forename: José S
authors.initials: JS
authors.lastname: Casas
authors.forename: María D
authors.initials: MD
authors.lastname: Couce
authors.forename: Agustín
authors.initials: A
authors.lastname: Sánchez
authors.forename: Rafael
authors.initials: R
authors.lastname: Seoane
authors.forename: José
authors.initials: J
authors.lastname: Sordo
authors.forename: José M
authors.initials: JM
authors.lastname: Varela
authors.forename: Ezequiel M
authors.initials: EM
authors.lastname: Vázquez-López
mesh_terms: D000838:Anions / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry*; D018030:Silver Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013455:Sulfur / Q000737:chemistry*
chemical_list: D000838:Anions; D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D018030:Silver Compounds; D012834:Silver; D013455:Sulfur