Vertically aligned carbon nanofiber arrays record electrophysiological signals from hippocampal slices.
Vertically aligned carbon nanofiber (VACNF) electrode arrays were tested for their potential application in recording neuro-electrophysiological activity. We report, for the first time, stimulation and extracellular recording of spontaneous and evoked neuroelectrical activity in organotypic hippocampal slice cultures with ultramicroelectrode VACNF arrays. Because the electrodes are carbon-based, these arrays have potential advantages over metal electrodes and could enable a variety of future applications as precise, informative, and biocompatible neural interfaces.
Yu
Zhe
Z
Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, 351 Engineering Terrace, New York, New York 10027, USA.
McKnight
Timothy E
TE
Ericson
M Nance
MN
Melechko
Anatoli V
AV
Simpson
Michael L
ML
Morrison
Barclay
B
D000818:Animals; D002478:Cells, Cultured; D003460:Crystallization / Q000379:methods; D004594:Electrophysiology / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006624:Hippocampus / Q000502:physiology*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008839:Microelectrodes; D008968:Molecular Conformation; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure*; D009415:Nerve Net / Q000502:physiology*; D010316:Particle Size; D051381:Rats; D013499:Surface Properties
D046911:Macromolecular Substances