title: Accumulation of bisphenol A in hemodialysis patients.
abstract: Bisphenol A [BPA, 2,2-bis(4-hydoxyphenyl)propane], an industrial chemical used in the production of polycarbonate, epoxide resin, and polyarylate, is considered to be an endocrine-disrupting chemical. BPA may be present in some hollow-fiber dialyzers used in hemodialysis. In this study, we tested the amounts of BPA eluted from various hollow fibers. Furthermore, we measured the BPA concentration in the sera of 22 renal disease predialysis patients, as well as 15 patients who were receiving hemodialysis, to see if there is BPA accumulation in these patients. The elution test of BPA showed that a much larger amount of BPA was eluted from polysulfone (PS), and polyester-polymeralloy hollow fibers. Among renal disease patients who had not undergone hemodialysis, the serum BPA concentration increased as the renal function deteriorated, showing a significant negative association. In a crossover test between PS and cellulose (Ce) dialyzers, the predialysis serum BPA concentration of PS dialyzer users decreased after changing to a Ce dialyzer, and the serum BPA increased again after switching back to PS dialyzers. In patients who were using PS dialyzers, the BPA level significantly increased after a dialysis session. However, in the Ce dialyzer users, the BPA level decreased. Since accumulation of BPA could affect the endocrine or metabolic system of the human body, it is important to perform further investigations on dialysis patients.
authors.affiliation: Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Japan. nephrokm@fj9.so-net.ne.jp
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Murakami
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Hori
authors.forename: Makoto
authors.initials: M
authors.lastname: Hibiya
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Shoji
authors.forename: Miyuki
authors.initials: M
authors.lastname: Kunisaki
authors.forename: Miho
authors.initials: M
authors.lastname: Akita
authors.forename: Akira
authors.initials: A
authors.lastname: Yagi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Sachiko
authors.initials: S
authors.lastname: Shimozato
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ito
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takahashi
authors.forename: Kouichirou
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Masami
authors.initials: M
authors.lastname: Kasugai
authors.forename: Nahoko
authors.initials: N
authors.lastname: Kawamura
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakai
authors.forename: Midori
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Tomita
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Nabeshima
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hiki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sugiyama
mesh_terms: D000368:Aged; D001559:Benzhydryl Compounds; D002482:Cellulose / Q000031:analogs & derivatives; D018592:Cross-Over Studies; D052244:Endocrine Disruptors / Q000032:analysis*; D004866:Equipment Contamination; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010636:Phenols / Q000032:analysis*; D011091:Polyesters; D011108:Polymers; D019904:Polymethyl Methacrylate; D006435:Renal Dialysis / Q000009:adverse effects / Q000295:instrumentation*; D012680:Sensitivity and Specificity; D013450:Sulfones; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002482:Cellulose; D052244:Endocrine Disruptors; D008567:Membranes, Artificial; D010636:Phenols; D011091:Polyesters; D011108:Polymers; D019904:Polymethyl Methacrylate; D013450:Sulfones; C017662:polysulfone P 1700; C024671:cellulose triacetate; C006780:bisphenol A; D000098826:Bisphenol A Compounds