title: Prevalence of macrocreatinkinase type 1 in patients with inflammatory bowel disease.
abstract: Macro-creatine-kinases are isoenzymes of creatinine-kinases (CK). They have been classified in two types: type 1 (CK bound to an immunoglobulin) and type 2 (an oligomeric mitochondrial CK). CK type 1 has been found in patients with ulcerative colitis (UC) but not in Crohn's disease (CD). However, there are no studies evaluating macro-creatinkinase prevalence in inflammatory bowel disease (IBD). We included 159 consecutive patients (72 UC, 85 CD; 2 indeterminate colitis). Creatin-kinase total activity and isoenzymes activities were determined. Twelve (16.7%) patients with UC and one of the two patients with indeterminate colitis had serum macro-creatinkinase type 1 while no CD patients displayed this macromolecule (P < 0,001). Sensitivity, specificity, positive and negative predictive value, and positive and negative likelihood ratio were calculated for ulcerative colitis versus Crohn's disease diagnosis, being 16.7, 98.9, 92.3, 59, 14.5, and 0.84% respectively. There was no correlation with age, gender, time from diagnosis, associated diseases, concomitant medication or disease activity. In conclusion our data suggests that the presence of macro-CK in IBD favors the diagnosis of ulcerative colitis. Further studies are necessary to understand the significance of this finding in a subset of patients with IBD.
authors.affiliation: Gastroenterology Unit, Fundación Hospital Alcorcon, Alcorcon, Spain. jlperezc@hotmail.com
authors.forename: J L
authors.initials: JL
authors.lastname: Perez-Calle
authors.forename: I
authors.initials: I
authors.lastname: Marin-Jimenez
authors.forename: P
authors.initials: P
authors.lastname: Lopez-Serrano
authors.forename: J P
authors.initials: JP
authors.lastname: Gisbert
authors.forename: A S
authors.initials: AS
authors.lastname: Pena
authors.forename: C
authors.initials: C
authors.lastname: Fernandez-Rodriguez
mesh_terms: D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000378:metabolism*; D003402:Creatine Kinase / Q000378:metabolism*; D003424:Crohn Disease / Q000175:diagnosis / Q000378:metabolism*; D004586:Electrophoresis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D003402:Creatine Kinase