title: Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report.
abstract: Teratomas comprise the most common extragonadal germ cell tumors in childhood. Most teratomas involving the thyroid are benign and occur in children. However, the adult cases reported are mostly malignant and commonly arise in the thyroid. We report a case of a 31-yr-old female with a huge neck mass. Pathologic examination revealed it to be malignant teratoma composed of primitive neuroepithelial tissue with primitive neural tubes and loose myxoid to fibrous immature mesenchymal stroma. The patient underwent extensive evaluation of the thyroid gland with computed tomography (CT) scan and positron emission tomography (PET) scan, which revealed no evidence of metastatic disease. She underwent total thyroidectomy with bilateral modified radical neck dissection, intensive chemotherapy and radiotherapy. At 22-months of follow-up, the patient has remained euthyroid and showed no evidence of recurrence. This is the first case, to our knowledge, of malignant thyroid teratoma with a exuberant primitive neuroectodermal tumor component in Korea.
authors.affiliation: Research Institute and Hospital, National Cancer Center, 809 Madu-1-dong, Ilsan-gu, Goyang, Korea.
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Kim
authors.forename: Tae Seok
authors.initials: TS
authors.lastname: Bae
authors.forename: Youngmee
authors.initials: Y
authors.lastname: Kwon
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Kim
authors.forename: Ki-Wook
authors.initials: KW
authors.lastname: Chung
authors.forename: Sun Wook
authors.initials: SW
authors.lastname: Kim
authors.forename: Jungsil
authors.initials: J
authors.lastname: Ro
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000328:Adult; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D009362:Neoplasm Metastasis; D018242:Neuroectodermal Tumors, Primitive / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods; D013724:Teratoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D013959:Thyroid Diseases / Q000175:diagnosis; D013961:Thyroid Gland / Q000473:pathology*; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed