Major depressive disorder and inflammatory markers in elderly patients with heart failure.
The authors evaluated levels of inflammatory markers in 34 chronic heart failure (CHF) out-patients age 65 years and over, with (N=18) and without (N=16) major depressive disorder (MDD), and healthy-control subjects (N=13). Patients with CHF had left-ventricular ejection fractions <0.40 and were in the New York Heart Association functional class II or III. The authors used the SCID DSM-IV to diagnosis MDD. High-sensitivity C-reactive protein levels were significantly higher in patients with CHF and MDD as compared with healthy-control subjects. No differences regarding tumor necrosis factor(alpha) or interleukin(6) were found among the three groups.
Andrei
Anna Maria
AM
Heart Institute, University of São Paulo School of Medicine, São Paulo, SP, Brazil.
Fraguas
Renerio
R
Telles
Renata M S
RM
Alves
Tânia C T F
TC
Strunz
Celia M C
CM
Nussbacher
Amit
A
Rays
Jairo
J
Iosifescu
Dan V
DV
Wajngarten
Mauricio
M
D000368:Aged; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D015995:Prevalence; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein