title: [Perinatal birth defects in 5 years in Changsha].
abstract: OBJECTIVE
  To investigate and analyze the occurrence of 64,101 perinatal birth defects from 2000 to 2004, to determine the tendency of the incidence rate of birth defects and perinatal mortality, and to explore feasible and effective intervention strategy.
  
  
  METHODS
  We investigated 64,101 perinatal infants who were born in 13 hospitals in Changsha from January 2000 to December 2004. The incidence rate of all birth defects, mortality of perinatal infants, the incidence rate of various kinds of birth defects, and the component rate of birth defects were analyzed.
  
  
  RESULTS
  Altogether 1,050 neonate birth defects were found, with the incidence rate of 1.638%. The incidence rate of birth defects was increasing year-by-year in 2000 compared with that in 2002, 2003 and 2004, with significant differences (all P values<0.05): the incidence rate of birth defects in 2001 compared with that in 2002, 2003 and 2004, also with significant differences (P<0.05). Eight hundred seventy nine perinatal infants died, and the mortality was 1.371%. The mortality perinatal of infants increased in 2001 compared with that in 2002 and in 2003, with significant differences (P<0.05). The top 5 birth defects with the highest incidence were congenital heart disease, polydactly, auricle malformation, cheiloschisis, and palatoschisis, congenital hydrocephal in turn. The incidences of congenital heart disease and hydrocephal increased significantly. One hundred seventy seven fetuses were performed induced labor because of fetal defects from 2003.
  
  
  CONCLUSIONS
  We must pay attention to the increasing tendency of birth defect incidence and perinatal mortality. Strengthening environmental protection and antenatal care can decrease the birth defect incidence. Performing antenatal examination and neonatal screening regularly can discover the birth defects in time. When severe birth defects occur, the induced labor should be performed.
authors.affiliation: Department of Neonatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Ping-yang
authors.initials: PY
authors.lastname: Chen
authors.forename: Zong-de
authors.initials: ZD
authors.lastname: Xie
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.forename: Mei-jun
authors.initials: MJ
authors.lastname: Ji
authors.forename: Si-qing
authors.initials: SQ
authors.lastname: Zhao
mesh_terms: D002681:China / Q000453:epidemiology; D000013:Congenital Abnormalities / Q000401:mortality*; D005260:Female; D006801:Humans; D015994:Incidence; D007226:Infant Mortality / Q000639:trends*; D007231:Infant, Newborn; D054238:Perinatal Mortality / Q000639:trends*; D011247:Pregnancy