title: Distribution of HSV-1 IgG antibodies by two methods comparing in Turkish atopic children.
abstract: Herpes Simplex Virus Type 1 (HSV-1) is a ubiquitous pathogen. Other than known diseases, HSV-1 may have an important role in the pathogenesis of atopy by causing immortality of th2 cells. From June 1st to July 31st 2006, seventy five blood samples were collected from atopic children referred to the allergy clinic of the hospital. The bloods samples were used to detect HSV-1 IgG antibodies by Enzyme-Linked Immunosorbent Assay and Virus Neutralization Test. HSV-1 IgG antibody seroprevalence in atopic children was found high, 62.6% by Enzyme-Linked Immunosorbent Assay and 57.3% by Virus Neutralization Test. Thus Virus Neutralization Test sensitivity was 92.15% and specificity was 100% regarding to the Enzyme-Linked Immunosorbent Assay technic. Although Enzyme-Linked Immunosorbent Assay was more sensitive than Virus Neutralization Test, there was no significant difference between two technics (p > 0.05) in detecting HSV-1 IgG antibodies in serum.
authors.affiliation: Department of Family Medicine, School of Medicine, Ondokuz Mayis University, Samsun, Turkey. fartiran@yahoo.com
authors.forename: Fusun
authors.initials: F
authors.lastname: Artiran Igde
authors.forename: Mahir
authors.initials: M
authors.lastname: Igde
authors.forename: Zafer
authors.initials: Z
authors.lastname: Yazici
authors.forename: Semra
authors.initials: S
authors.lastname: Okur Gumusova
authors.forename: Asuman
authors.initials: A
authors.lastname: Birinci
authors.forename: Recep
authors.initials: R
authors.lastname: Sancak
authors.forename: Fadil
authors.initials: F
authors.lastname: Ozturk
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D045744:Cell Line, Tumor; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006561:Herpes Simplex / Q000453:epidemiology / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000821:virology*; D007074:Immunoglobulin G / Q000097:blood*; D009500:Neutralization Tests / Q000379:methods*; D012680:Sensitivity and Specificity; D016036:Seroepidemiologic Studies; D014421:Turkey
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G