title: Adjuvant therapy after radical surgery of cervical cancer: Zagreb experience.
abstract: The results of the analysis of the treatment of 72 patients with carcinoma of the uterine cervix are presented. Seventy-two patients with Stage IB1 carcinoma of the cervix underwent a radical hysterectomy and pelvic lymphadenectomy. The low-risk group includes the patients without unfavourable prognostic factors that were treated by surgery alone. The high-risk group included women with pelvic node metastases, clinical tumour size greater than 3.0 cm, depth of stromal invasion greater than 1/3 of the cervical wall, Grade 3 tumours and the presence of lympho-vascular space involvement. High-risk patients received whole pelvic radiotherapy between two and four weeks following surgery. Thirty-four patients (47.2%) were in the low-risk group and thirty-eight patients (52.8%) were in the high-risk group. Locoregional recurrences were diagnosed in three cases (8.8%) in the surgery group and in four patients (10.5 %) assigned to postoperative radiotherapy. The incidence of distant metastases was 2.9% in the group treated by surgery alone and 5.3% in the group treated by surgery and radiotherapy. Overall survival at five years was 91.2% in the low-risk group and 89.5% in the high-risk group of patients. Five-year overall survival, locoregional and distant metastases were similar in the low-risk and high-risk groups of patients, which emphasizes the value of whole pelvic radiation in patients with one or more unfavourable prognostic factors after radical surgery in Stage IB1 cervical cancer
authors.affiliation: Department of Gynecology and Obstetrics School of Medicine Merkur University Hospital, Zagreb, Croatia. vlastimir.kukura@zg.htnet.hr
authors.forename: Vlastimir
authors.initials: V
authors.lastname: Kukura
authors.forename: Srećko
authors.initials: S
authors.lastname: Ciglar
authors.forename: Lijerka
authors.initials: L
authors.lastname: Markulin-Grgić
authors.forename: Fedor
authors.initials: F
authors.lastname: Santek
mesh_terms: D000328:Adult; D017024:Chemotherapy, Adjuvant; D017523:Croatia; D005260:Female; D006801:Humans; D008875:Middle Aged; D011182:Postoperative Care; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*