Plasmodium vivax infection among Duffy antigen-negative individuals from the Brazilian Amazon region: an exception?
We present evidence for Plasmodium vivax infection among Duffy blood group-negative inhabitants of Brazil. The P. vivax identification was determined by both genotypic and non-genotypic screening tests. The Duffy blood group was genotyped by PCR/RFLP and phenotyped using a microtyping kit. We detected two homozygous FY*B-33 carriers infected by P. vivax, whose circumsporozoite protein genotypes were VK210 and/or P. vivax-like. Additional efforts are necessary in order to clarify the evidence that P. vivax is being transmitted among Duffy blood group-negative patients from the Brazilian Amazon region.
Cavasini
Carlos Eugênio
CE
Faculty of Medicine, São José do Rio Preto, Av. Brigadeiro Faria Lima 5416, 15090-000 São José do Rio Preto, São Paulo State, Brazil. cecavasini@famerp.br
Mattos
Luiz Carlos de
LC
Couto
Alvaro Augusto D'Almeida
AA
Bonini-Domingos
Cláudia Regina
CR
Valencia
Socrates Herrera
SH
Neiras
Wanessa Christina de Souza
WC
Alves
Renata Tomé
RT
Rossit
Andréa Regina Baptista
AR
Castilho
Lilian
L
Machado
Ricardo Luiz Dantas
RL
D001938:Brazil / Q000453:epidemiology; D004375:Duffy Blood-Group System / Q000235:genetics / Q000276:immunology*; D005260:Female; D006801:Humans; D016780:Malaria, Vivax / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D008297:Male
D004375:Duffy Blood-Group System