title: No association of common VCP variants with sporadic frontotemporal dementia.
abstract: Mutations in the gene for valosin containing protein (VCP) cause autosomal dominant inclusion body myopathy associated with Paget disease and frontotemporal dementia (IBMPFD). To investigate the role of this novel gene in sporadic forms of frontotemporal dementia (FTD), we genotyped 27 single nucleotide polymorphisms covering the entire VCP genomic region in 198 patients with sporadic FTD and 184 matched controls from Germany. No significant association could be demonstrated. There is no evidence, that common variants in VCP confer a strong risk to the development of sporadic FTD.
authors.affiliation: Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry, TU-Munich, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Schumacher
authors.forename: Patricia
authors.initials: P
authors.lastname: Friedrich
authors.forename: Janine
authors.initials: J
authors.lastname: Diehl
authors.forename: Bernd
authors.initials: B
authors.lastname: Ibach
authors.forename: Andreas
authors.initials: A
authors.lastname: Schoepfer-Wendels
authors.forename: Jakob C
authors.initials: JC
authors.lastname: Mueller
authors.forename: Lidija
authors.initials: L
authors.lastname: Konta
authors.forename: Simon M
authors.initials: SM
authors.lastname: Laws
authors.forename: Alexander
authors.initials: A
authors.lastname: Kurz
authors.forename: Hans
authors.initials: H
authors.lastname: Foerstl
authors.forename: Matthias
authors.initials: M
authors.lastname: Riemenschneider
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D003704:Dementia / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D014644:Genetic Variation; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D000074405:Valosin Containing Protein
chemical_list: D018797:Cell Cycle Proteins; D000251:Adenosine Triphosphatases; C000614178:VCP protein, human; D000074405:Valosin Containing Protein