title: An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: a collaborative retrospective study.
abstract: BACKGROUND
  Adenomatoid odontogenic tumour (AOT) is a benign odontogenic jaw lesion. The aim of this study was to update the biological profile of AOT.
  
  
  METHODS
  Cases published in the literature and cases in files of co-authors were included.
  
  
  RESULTS
  550 new cases were retrieved, and of a total of 1082 cases analysed, 87.2% were found in the second and third decades. The M:F ratio was 1:1.9. 70.8% were of the follicular variant (extrafollicular: 26.9%, peripheral: 2.3%). 64.3% occurred in the maxilla. 60% of follicular AOTs were associated with unerupted canines. Nineteen cases of AOT (2.8%, M:F ratio was 1:1.4) were associated with embedded third molars. Twenty-two peripheral AOTs (2.3%, M:F ratio was 1:5.3) were recorded. The relative frequency (RF) of AOT ranged between 0.6% and 38.5%, revealing a considerably wider AOT/RF range than hitherto reported (2.2-7.1%).
  
  
  CONCLUSIONS
  This updated review based on the largest number of AOT cases ever presented, confirms the distinctive, although not pathognomonic clinicopathological profile of the AOT, its worldwide occurrence, and its consistently benign behaviour.
authors.affiliation: Edificio El Condór 30, Urb. Guadalmina Alta, San Pedro de Alcántara, Spain.
authors.forename: Hans Peter
authors.initials: HP
authors.lastname: Philipsen
authors.forename: Peter A
authors.initials: PA
authors.lastname: Reichart
authors.forename: Chong Huat
authors.initials: CH
authors.lastname: Siar
authors.forename: Kok Han
authors.initials: KH
authors.lastname: Ng
authors.forename: Shin Hin
authors.initials: SH
authors.lastname: Lau
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhang
authors.forename: Kittipong
authors.initials: K
authors.lastname: Dhanuthai
authors.forename: Somporn
authors.initials: S
authors.lastname: Swasdison
authors.forename: Aree
authors.initials: A
authors.lastname: Jainkittivong
authors.forename: Shabnum
authors.initials: S
authors.lastname: Meer
authors.forename: Vibha
authors.initials: V
authors.lastname: Jivan
authors.forename: Mario
authors.initials: M
authors.lastname: Altini
authors.forename: Vinay
authors.initials: V
authors.lastname: Hazarey
authors.forename: Ikuko
authors.initials: I
authors.lastname: Ogawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Takata
authors.forename: Adalberto Abel Mosqueda
authors.initials: AA
authors.lastname: Taylor
authors.forename: Héctor
authors.initials: H
authors.lastname: Godoy
authors.forename: Wilson A
authors.initials: WA
authors.lastname: Delgado
authors.forename: Roman
authors.initials: R
authors.lastname: Carlos-Bregni
authors.forename: Juan Fransisco Reyes
authors.initials: JF
authors.lastname: Macias
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsuzaka
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sato
authors.forename: Pablo A
authors.initials: PA
authors.lastname: Vargas
authors.forename: Ezekiel Taiwo
authors.initials: ET
authors.lastname: Adebayo
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000569:Americas / Q000453:epidemiology; D001208:Asia / Q000453:epidemiology; D002648:Child; D003481:Cuspid / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D007573:Jaw Neoplasms / Q000453:epidemiology*; D008297:Male; D008339:Mandibular Neoplasms / Q000453:epidemiology; D008441:Maxillary Neoplasms / Q000453:epidemiology; D008964:Molar, Third / Q000473:pathology; D009808:Odontogenic Tumors / Q000453:epidemiology*; D012189:Retrospective Studies; D012737:Sex Factors; D014095:Tooth, Impacted / Q000453:epidemiology; D014097:Tooth, Unerupted / Q000453:epidemiology