title: Reduced platelet serotonergic responsivity as assessed by dense granule secretion in first-episode psychosis.
abstract: OBJECTIVE
  To determine whether blunted serotonergic responsivity, indicated by decreased platelet dense granule secretion (DGS), occurs in neuroleptic-naïve patients with schizophrenia, as observed previously in chronic schizophrenia.
  
  
  METHODS
  Serotonin (5-HT)-amplified DGS was examined in 40 first-episode neuroleptic-naïve patients (24 with schizophrenia and 16 with mood disorders) and 24 healthy subjects.
  
  
  RESULTS
  Healthy controls showed robustly increased DGS. Schizophrenic patients showed very modest DGS increases; mood disorder patients showed intermediate response.
  
  
  CONCLUSIONS
  Blunted DGS appears to a characteristic of schizophrenia that is observed in the treatment-naïve condition.
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA.
authors.forename: Ravinder D
authors.initials: RD
authors.lastname: Reddy
authors.forename: Matcheri S
authors.initials: MS
authors.lastname: Keshavan
authors.forename: Jeffrey K
authors.initials: JK
authors.lastname: Yao
mesh_terms: D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D019964:Mood Disorders / Q000097:blood / Q000175:diagnosis; D010974:Platelet Aggregation / Q000187:drug effects; D011618:Psychotic Disorders / Q000097:blood* / Q000175:diagnosis; D012559:Schizophrenia / Q000097:blood / Q000175:diagnosis; D012701:Serotonin / Q000494:pharmacology*
chemical_list: D012701:Serotonin