Viral monitoring and successful treatment of a ganciclovir-resistant cytomegalovirus infection in a heart transplant recipient.
We reported a ganciclovir (GCV)-resistant cytomegalovirus (CMV) infection in a heart transplant recipient. Genotypic and phenotypic susceptibility assays demonstrated an A594V mutation in the UL97 phosphotransferase gene and GCV IC(50)>96 microM. Low GCV concentration exposure, immunosuppressive treatment, donor-positive/recipient-negative CMV serostatus, viral reactivations within antiviral prophylaxis or treatment, contributed to GCV-resistant strain selection.
García-Martínez
J
J
Department of Microbiology, Madrid, Spain. jgarciam.hflr@salud.madrid.org
Folgueira
L
L
Delgado
R
R
Hernando
S
S
Prieto
C
C
Aguado
J M
JM
Otero
J R
JR
D000328:Adult; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000187:drug effects*; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D015774:Ganciclovir / Q000494:pharmacology* / Q000627:therapeutic use; D016027:Heart Transplantation; D006801:Humans; D016896:Treatment Outcome; D019562:Viral Load
D000998:Antiviral Agents; D015774:Ganciclovir