title: Nanostructured lipid carriers (NLC) in cosmetic dermal products.
abstract: The first generation of lipid nanoparticles was introduced as solid lipid nanoparticles (SLN), the second, improved generation as nanostructured lipid carriers (NLC). Identical to the liposomes, the lipid nanoparticles (NLC) appeared as products first on the cosmetic market. The article gives an overview of the cosmetic benefits of lipid nanoparticles, that means enhancement of chemical stability of actives, film formation, controlled occlusion, skin hydration, enhanced skin bioavailability and physical stability of the lipid nanoparticles as topical formulations. NLC are on the market as concentrates to be used as cosmetic excipients, special formulation challenges for these products are discussed. NLC appeared also in a number of finished cosmetic products world-wide. An overview of these products is provided including their special effects due to the lipid nanoparticles, lipids used for their production and incorporated cosmetic actives.
authors.affiliation: Freie Universität Berlin, Department of Pharmaceutical Technology, Biopharmaceutics and NutriCosmetics, Kelchstrasse 31, 12169 Berlin, Germany. mpharma@zedat.fu-berlin.de
authors.forename: R H
authors.initials: RH
authors.lastname: Müller
authors.forename: R D
authors.initials: RD
authors.lastname: Petersen
authors.forename: A
authors.initials: A
authors.lastname: Hommoss
authors.forename: J
authors.initials: J
authors.lastname: Pardeike
mesh_terms: D000287:Administration, Topical; D003358:Cosmetics / Q000008:administration & dosage*; D004337:Drug Carriers; D005079:Excipients / Q000008:administration & dosage; D006801:Humans; D008055:Lipids / Q000008:administration & dosage; D049329:Nanostructures
chemical_list: D003358:Cosmetics; D004337:Drug Carriers; D005079:Excipients; D008055:Lipids