High-throughput mass spectrometry: the mechanism of sudan azo dye fragmentation by ESI tandem mass spectrometry and extensive deuterium labeling experiments.
The investigation of the gas-phase chemistry of azo compounds by mass spectrometry dates back to the introduction of this peculiar research field into the armory of physical organic chemistry tools. The mechanism of the fragmentation of the azo double bond from the protonated precursor is discussed with reference to the behavior of deuterium-labeled reference compounds. The investigated molecules belong to the sudan family and the results can be used for the detection of these potential carcinogenic compounds in different matrices by means of the isotope dilution method.
Di Donna
Leonardo
L
Dipartimento di Chimica, Università della Calabria, I-87030 Arcavacata di Rende (CS), Italy.
De Nino
Antonio
A
Maiuolo
Loredana
L
Mazzotti
Fabio
F
Napoli
Anna
A
Salerno
Raffaele
R
Sindona
Giovanni
G
D001391:Azo Compounds / Q000737:chemistry*; D004396:Coloring Agents / Q000737:chemistry*; D003903:Deuterium / Q000737:chemistry*; D005740:Gases / Q000737:chemistry; D007553:Isotope Labeling; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
D001391:Azo Compounds; D004396:Coloring Agents; D005740:Gases; D003903:Deuterium