title: Disseminated histoplasmosis and tuberculosis in a patient with HIV infection.
abstract: Histoplasmosis is a very rare disease in Korea. Clinical manifestations are very similar to those of tuberculosis. This is the first case report of combined disseminated histoplasmosis and tuberculosis in a patient with HIV infection in Korea. A 42-year-old Korean with Acquired Immunodeficiency Syndrome (AIDS) was diagnosed with tuberculosis. He had lived in Guatemala for the past five years. Upon diagnosis of disseminated tuberculosis with HIV infection, he was treated with anti-tuberculosis medications and anti-retroviral agents. Fever, weakness, hepatosplenomegaly and pancytopenia were persistent despite treatment. The patient's history of living in Guatemala caused us to seek opportunistic infectious organisms other than tuberculosis. Bone marrow aspiration and biopsy were performed and the result revealed numerous intracellular organisms consistent with Histoplasma capsulatum; therefore, the diagnosis of disseminated histoplasmosis was made.
authors.affiliation: Department of Laboratory Medicine, Korea University College of Medicine, Anam- dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea. eqcho1ku@korea.ac.kr
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Jeong
authors.forename: Jang-Wook
authors.initials: JW
authors.lastname: Sohn
authors.forename: Min Ja
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jung Woo
authors.initials: JW
authors.lastname: Choi
authors.forename: Chul Hwan
authors.initials: CH
authors.lastname: Kim
authors.forename: Sang-Ho
authors.initials: SH
authors.lastname: Choi
authors.forename: Jeeyong
authors.initials: J
authors.lastname: Kim
authors.forename: Yunjung
authors.initials: Y
authors.lastname: Cho
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology; D000328:Adult; D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D013909:Thorax / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D014376:Tuberculosis / Q000150:complications / Q000175:diagnosis*