title: Resting EEG sources correlate with attentional span in mild cognitive impairment and Alzheimer's disease.
abstract: Previous evidence has shown that resting delta and alpha electroencephalographic (EEG) rhythms are abnormal in patients with Alzheimer's disease (AD) and its potential preclinical stage (mild cognitive impairment, MCI). Here, we tested the hypothesis that these EEG rhythms are correlated with memory and attention in the continuum across MCI and AD. Resting eyes-closed EEG data were recorded in 34 MCI and 53 AD subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography (LORETA). These sources were correlated with neuropsychological measures such as Rey list immediate recall (word short-term memory), Rey list delayed recall (word medium-term memory), Digit span forward (immediate memory for digits probing focused attention), and Corsi span forward (visuo-spatial immediate memory probing focused attention). A statistically significant negative correlation (Bonferroni corrected, P < 0.05) was observed between Corsi span forward score and amplitude of occipital or temporal delta sources across MCI and AD subjects. Furthermore, a positive correlation was shown between Digit span forward score and occipital alpha 1 sources (Bonferroni corrected, P < 0.05). These results suggest that cortical sources of resting delta and alpha rhythms correlate with neuropsychological measures of immediate memory based on focused attention in the continuum of MCI and AD subjects.
authors.affiliation: Dip. Fisiologia Umana e Farmacologia, Università degli Studi di Roma La Sapienza, P.le Aldo Moro 5, 00185 Rome, Italy. claudio.babiloni@uniroma1.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Babiloni
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cassetta
authors.forename: Giuliano
authors.initials: G
authors.lastname: Binetti
authors.forename: Mario
authors.initials: M
authors.lastname: Tombini
authors.forename: Claudio
authors.initials: C
authors.lastname: Del Percio
authors.forename: Florinda
authors.initials: F
authors.lastname: Ferreri
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ferri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Frisoni
authors.forename: Bartolo
authors.initials: B
authors.lastname: Lanuzza
authors.forename: Flavio
authors.initials: F
authors.lastname: Nobili
authors.forename: Laura
authors.initials: L
authors.lastname: Parisi
authors.forename: Guido
authors.initials: G
authors.lastname: Rodriguez
authors.forename: Leonardo
authors.initials: L
authors.lastname: Frigerio
authors.forename: Mariella
authors.initials: M
authors.lastname: Gurzì
authors.forename: Annapaola
authors.initials: A
authors.lastname: Prestia
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vernieri
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Eusebi
authors.forename: Paolo M
authors.initials: PM
authors.lastname: Rossini
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology; D003072:Cognition Disorders / Q000473:pathology / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology; D012146:Rest