title: Vacuum-assisted large-core needle biopsy (VLNB) improves the management of patients with breast microcalcifications - analysis of 1009 cases.
abstract: OBJECTIVE
  To evaluate the surgical management of patients who underwent VLNB for breast microcalcifications.
  
  
  METHODS
  This retrospective study compared the histological results and the surgical procedures in two groups of patients, group 1: large-core needle biopsy n=1009, and group 2: surgical biopsy n=270.
  
  
  RESULTS
  After VLNB, 54% patients were not operated on after stereotactic large-core needle biopsy, 42% underwent one operation, 4% underwent two operations and 0.2% underwent three operations. No surgery was performed for 95% of benign lesions. Multiples operations were necessary in 12% of patients with malignant lesions of VLNB group compared to 45% in the surgical biopsy group. The rate of underdiagnosis of borderline lesions and ductal carcinomas in situ was 16% by the large-core biopsy technique.
  
  
  CONCLUSIONS
  VLNB constitutes an alternative to surgical biopsy. This procedure avoids surgery for most benign lesions and reduces the number of surgical procedures in malignant lesions.
authors.affiliation: Institut Curie, Department of Tumour Biology, 26 rue d'Ulm, 75248 Paris Cedex 05, France. brigitte.sigal@curie.net
authors.forename: B
authors.initials: B
authors.lastname: Sigal-Zafrani
authors.forename: K
authors.initials: K
authors.lastname: Muller
authors.forename: C
authors.initials: C
authors.lastname: El Khoury
authors.forename: P C
authors.initials: PC
authors.lastname: Varoutas
authors.forename: C
authors.initials: C
authors.lastname: Buron
authors.forename: A
authors.initials: A
authors.lastname: Vincent-Salomon
authors.forename: S
authors.initials: S
authors.lastname: Alran
authors.forename: A
authors.initials: A
authors.lastname: Livartowski
authors.forename: S
authors.initials: S
authors.lastname: Neuenschwander
authors.forename: R J
authors.initials: RJ
authors.lastname: Salmon
mesh_terms: D001707:Biopsy, Needle; D001941:Breast Diseases / Q000473:pathology* / Q000601:surgery*; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery; D002114:Calcinosis / Q000473:pathology* / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D012189:Retrospective Studies