STK15 F31I polymorphism is associated with increased uterine cancer risk: a pilot study.
OBJECTIVE
STK15 is a serine threonine kinase which assists chromosomal separation and mitotic spindle stability through interaction with the centrosome during mitosis. We hypothesized that STK15 polymorphisms might modulate the risk of uterine cancer.


METHODS
We used a hospital-based case-control study to assess the association between STK15 polymorphisms and risk of uterine cancer. Cases and controls were matched on age, race, and smoking status. Two common STK15 single nucleotide polymorphisms (SNPs), F31I (T/A), and V57I (G/A), were genotyped. Odds ratios (OR) and 95% confidence intervals (CI) were obtained using unconditional logistic regression analysis.


RESULTS
A total of 193 women with uterine cancer and 218 controls were genotyped for both SNPs. After adjustment for age, race, and smoking status for the F31I SNP, the homozygous variant genotype (AA) was associated with a significantly increased uterine cancer risk (OR 10.2; 95% CI 2.23-46.5). Individuals with the heterozygous genotype (TA) and a history of tobacco use also exhibited an increased risk for uterine cancer (OR 2.63; 95% CI 1.20-5.76). For the V57I SNP, neither the homozygous (AA) nor the heterozygous (GA) variant genotypes were associated with significantly altered risk for uterine cancer (OR 0.76; 95% CI 0.18-3.25 and OR 0.88; 95% CI 0.52-1.49).


CONCLUSIONS
Our study demonstrates that STK15 F31I SNP is associated with an increased risk for uterine cancer. Confirmation of this pilot study is needed in a larger case-control population to evaluate this genetic variant with other known risk factors for uterine cancer.
Milam
Michael R
MR
Department of Gynecologic Oncology, University of Texas M.D. Anderson Cancer Center, 1155 Herman P. Pressler St, CPB 6.3244, Unit 1362, Houston, TX 77030, USA.
Gu
Jian
J
Yang
Hushan
H
Celestino
Joseph
J
Wu
Weiguo
W
Horwitz
Irwin B
IB
Lacour
Robin A
RA
Westin
Shannon N
SN
Gershenson
David M
DM
Wu
Xifeng
X
Lu
Karen H
KH
D064096:Aurora Kinase A; D064127:Aurora Kinases; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012907:Smoking; D014594:Uterine Neoplasms / Q000235:genetics*
C576917:AURKA protein, human; D064096:Aurora Kinase A; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases