[Usefulness of equations based on serum cystatin C concentration in the study of renal function].
Serum creatinine is an insensitive marker to identify early changes in glomerular filtration rate (GFR), for this reason alternative methods to estimate renal function result of great clinical importance. Forty-one patients were studied using creatinine clearance modified with cimetidina (Clcrc) as surrogate of GFR, cystatin C-based equations (i.e. Larsson and Hoek formulas), Cockroft-Gault and MDRD abbreviated equations. In the whole group, as well as in those patients with serum creatinine < or =1.2 mg/dl--but reduced renal function: Clcrc 62.01 +/- 17.33 ml/ min/1.73 m(2)-, Larsson and Hoek equations showed higher correlations and lower bias than creatinine-based formulas. Abbreviated MDRD equation showed good performance just in those patients with evident alteration of renal function (serum creatinine > 1.2 mg/dl). We concluded that in patients with different stages of renal function, cystatin C-based equations detect reduction of renal function earlier than the serum creatinine-based formulas.
Chiurchiu
Carlos
C
Servicio de Nefrologia, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina.
Garces
Nilda
N
Garay
Gabriela
G
Holtz
Rosmarie
R
Douthat
Walter
W
de Arteaga
Javier
J
Capra
Raul
R
Massari
Pablo U
PU
D015415:Biomarkers / Q000097:blood; D002927:Cimetidine / Q000008:administration & dosage; D003404:Creatinine / Q000037:antagonists & inhibitors / Q000097:blood*; D055316:Cystatin C; D015891:Cystatins / Q000037:antagonists & inhibitors / Q000097:blood*; D003627:Data Interpretation, Statistical; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D004791:Enzyme Inhibitors; D002927:Cimetidine; D003404:Creatinine