title: A constrained polynomial regression procedure for estimating the local False Discovery Rate.
abstract: BACKGROUND
  In the context of genomic association studies, for which a large number of statistical tests are performed simultaneously, the local False Discovery Rate (lFDR), which quantifies the evidence of a specific gene association with a clinical or biological variable of interest, is a relevant criterion for taking into account the multiple testing problem. The lFDR not only allows an inference to be made for each gene through its specific value, but also an estimate of Benjamini-Hochberg's False Discovery Rate (FDR) for subsets of genes.
  
  
  RESULTS
  In the framework of estimating procedures without any distributional assumption under the alternative hypothesis, a new and efficient procedure for estimating the lFDR is described. The results of a simulation study indicated good performances for the proposed estimator in comparison to four published ones. The five different procedures were applied to real datasets.
  
  
  CONCLUSIONS
  A novel and efficient procedure for estimating lFDR was developed and evaluated.
authors.affiliation: JE 2492-Univ. Paris-Sud, Villejuif, France. dalmasso@vjf.inserm.fr
authors.forename: Cyril
authors.initials: C
authors.lastname: Dalmasso
authors.forename: Avner
authors.initials: A
authors.lastname: Bar-Hen
authors.forename: Philippe
authors.initials: P
authors.lastname: Broët
mesh_terms: D000465:Algorithms; D051017:Apoptosis Regulatory Proteins; D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D005189:False Positive Reactions; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D009363:Neoplasm Proteins / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D011336:Probability; D012044:Regression Analysis
chemical_list: D051017:Apoptosis Regulatory Proteins; C118024:BLID protein, human; D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D009363:Neoplasm Proteins