Cranial leiomyosarcoma in an Epstein-Barr virus (EBV)-mismatched lung transplant recipient.
Leiomyosarcoma is a rare Epstein-Barr virus (EBV)-related complication of solid-organ transplantation. We report the case of a 19-year-old woman with cystic fibrosis who presented with protracted headaches 15 months after an EBV-mismatched bilateral sequential lung transplant. A parasagittal lesion was found on cranial magnetic resonance imaging; surgical resection revealed a leiomyosarcoma. We discuss treatment options of what is, to our knowledge, the first described case of a cranial leiomyosarcoma in a lung transplant recipient.
Chaves
Nadia J
NJ
Heart and Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
Kotsimbos
Tom C
TC
Warren
Mark A
MA
McLean
Catriona A
CA
Spelman
Denis W
DW
Williams
Trevor J
TJ
Snell
Greg I
GI
Westall
Glen P
GP
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000821:virology*; D003550:Cystic Fibrosis / Q000601:surgery; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000473:pathology / Q000821:virology*; D016040:Lung Transplantation / Q000009:adverse effects* / Q000276:immunology; D008279:Magnetic Resonance Imaging; D014775:Virus Activation / Q000502:physiology
D000914:Antibodies, Viral