A case of human polyomavirus Bk infection in a patient affected by late stage prostate cancer: could viral infection be correlated with cancer progression?
The basic molecular mechanisms regulating prostate cancer (PCA) development and progression are very poorly understood. Different tumor suppressor genes are implicated in PCA. In particular, since the mutation rate of the p53 gene is also low, researchers have speculated that an infectious agent might play an important role in PCA. Polyomaviruses are candidates for this agent. We selected a patient with a diagnosis of PCA and underwent radical prostatectomy, to investigate the presence of polyomavirus BK (BKV) sequences (urine and neoplastic tissues) and the mutation pattern of p53 gene. The results obtained showed the presence of BKV DNA and of p53 gene mutations in exons 6, 8 and 9. We speculate that BKV might contribute to cellular transformation process, triggered possibly by p53 gene mutations.
Fioriti
D
D
Department of Public Health Sciences, La Sapienza University, Rome, Italy.
Russo
G
G
Mischitelli
M
M
Anzivino
E
E
Bellizzi
A
A
Di Monaco
F
F
Di Silverio
F
F
Giordano
A
A
Chiarini
F
F
Pietropaolo
V
V
D000368:Aged; D001739:BK Virus / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D008297:Male; D027601:Polyomavirus Infections / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000473:pathology*