title: Unusual dermatological toxicity of hydroxyurea in two dogs with spontaneously occurring tumours.
abstract: Hydroxyurea is a chemotherapeutic agent used to treat hypereosinophilic syndrome, mast cell tumours and many myeloproliferative disorders. It is usually well tolerated; however, reported side effects include myelosuppression and gastrointestinal complications as well as cutaneous toxicity, in very rare cases. We report the unusual appearance of onychomadesis involving several claws on all feet in two canine patients receiving long-term hydroxyurea treatment. The healing of nail lesions required cessation of treatment in one dog and dose reduction in the second animal, supporting a strict relationship between onychopathy and administration of hydroxyurea. The aim of this case report is to increase clinical awareness of dermatological toxicity associated with long-term administration of hydroxyurea.
authors.affiliation: Clinica Veterinaria L'Arca, Vico Cacciottoli 46/47, 80129 Naples, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Marconato
authors.forename: U
authors.initials: U
authors.lastname: Bonfanti
authors.forename: I
authors.initials: I
authors.lastname: Fileccia
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D005534:Foot Diseases / Q000139:chemically induced / Q000662:veterinary*; D006724:Hoof and Claw / Q000473:pathology*; D006918:Hydroxyurea / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea