title: [Absolute risk for fracture and WHO guideline. Biological markers for osteoarthritis (OA)].
abstract: Biological markers for osteoarthritis (OA) are indicators of articular tissue metabolism, measuring the levels of molecules derived from joint structures into synovial fluids, serum and urine. Radiological findings are the basis of diagnosis of OA, but have a weakpoint visualizing the figures that have already occurred. For assessing disease activity or monitoring disease progression, estimation of articular metabolism using biological markers is very important. Synovial fluid reflects specifically the status of the punctured joint, however invasive. Less-invasive newly developed serum and urine markers appear to be also useful for the evaluation of OA.
authors.affiliation: Fujita Health University, Department of Orthopaedic Surgery.
authors.forename: Hideki
authors.initials: H
authors.lastname: Date
authors.forename: Harumoto
authors.initials: H
authors.lastname: Yamada
authors.forename: Arihiko
authors.initials: A
authors.lastname: Kanaji
authors.forename: Kaori
authors.initials: K
authors.lastname: Tajima
authors.forename: Kazue
authors.initials: K
authors.lastname: Hayakawa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Maehara
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Masuda
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000652:urine; D064236:Cartilage Oligomeric Matrix Protein; D024043:Collagen Type II / Q000652:urine*; D016326:Extracellular Matrix Proteins / Q000097:blood*; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D064235:Matrilin Proteins; D010003:Osteoarthritis / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D024043:Collagen Type II; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; C577553:TSP5 protein, human; D006820:Hyaluronic Acid