Chiral separation of sympathomimetics and beta-blockers by ligand-exchange CE using Cu(II) complexes of L-tartaric acid and L-threonine as chiral selectors.
This paper deals with the use of Cu(II) complexes of L-tartaric acid or L-threonine as selectors for the chiral separation of drugs containing amino alcohol structure by ligand-exchange CE. Using Cu(II) ions as a complexing agent, a series of sympathomimetics and beta-blockers were resolved. It was found that the resolution strongly depends on selector concentration and pH. The optimum pH for complexation was 12.
Hödl
Heike
H
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, Karl-Franzens-University, Graz, Austria.
Krainer
Axel
A
Holzmüller
Katja
K
Koidl
Julia
J
Schmid
Martin G
MG
Gübitz
Gerald
G
D000319:Adrenergic beta-Antagonists / Q000302:isolation & purification*; D000605:Amino Alcohols / Q000302:isolation & purification*; D003300:Copper; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D013237:Stereoisomerism; D013566:Sympathomimetics / Q000302:isolation & purification*; D013644:Tartrates; D013912:Threonine
D000319:Adrenergic beta-Antagonists; D000605:Amino Alcohols; D008024:Ligands; D013566:Sympathomimetics; D013644:Tartrates; D013912:Threonine; D003300:Copper; C029768:tartaric acid