Functional activity of 5-HT4 receptors in children with congenital heart disease.
The effect of 5-methoxytryptamine (5-HT(4) receptor agonist) on the inotropic function of atrial myocardium was studied in children aged 2 months to 17 years, operated on for congenital heart disease. Functional activity of 5-HT(4) receptors was 8.4 times higher in dysfunction of the atrial septum in comparison with other congenital heart diseases. The positive inotropic effects of 5-HT(4) receptor agonist can promote compensation of myocardial work in children with pathological circulation.
Mustafin
A A
AA
Kazan State Medical University, Kazan, Russia. mustafinnn@mail.ru
Nigmatullina
R R
RR
Mirolyubov
L M
LM
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism / Q000601:surgery; D006330:Heart Defects, Congenital / Q000150:complications* / Q000601:surgery; D006344:Heart Septal Defects, Atrial / Q000150:complications / Q000601:surgery; D006801:Humans; D007223:Infant; D009206:Myocardium / Q000378:metabolism; D044422:Receptors, Serotonin, 5-HT4 / Q000378:metabolism*; D058828:Serotonin 5-HT4 Receptor Agonists
D058828:Serotonin 5-HT4 Receptor Agonists; D044422:Receptors, Serotonin, 5-HT4; D008735:5-Methoxytryptamine