title: Dynamics of dot-like hemosiderin spots on T2*-weighted MRIs associated with stroke recurrence.
abstract: OBJECTIVE
  Dot-like low-intensity spots (dot-like hemosiderin spots: dotHSs) on gradient echo T2*-weighted (-w) brain magnetic resonance imaging (MRIs) are frequently associated with cerebral small vessel disease (SVD), including deep intracerebral hemorrhages and lacunar infarctions. This study investigated how numbers of newly appeared dotHSs contribute to recurrent SVD.
  
  
  METHODS
  We prospectively analyzed numbers of newly appeared dotHSs in 12 patients with prior SVD (8 males, 4 females; mean 67.6 +/- 10.7 years old) readmitted with recurring SVD between October 2001 and March 2003. Numbers of appeared dotHSs per year were counted on T2*-w MRI scans after SVD recurrence and compared to previous MRIs. Seventy-one outpatients (35 males, 36 females; mean 64.3 +/- 9.6 years old) with histories of intracerebral hemorrhages (ICH) that came to the hospital during the study period served as controls. The hazard ratio (HR) for recurrence was estimated from a multivariate logistic regression model, using the number of appeared dotHSs (per year) and other risk factors.
  
  
  RESULTS
  Multivariate analyses revealed that an elevated rate of recurrence was found in patients with substantial numbers of appeared dotHSs (>or=5/year) (HR, 7.34; P= 0.0008). We also analyzed factors associated with the numbers of appeared dotHSs. A number of appeared dotHSs (>or=5/year) was significantly and independently associated with the initial number of dotHSs (>or=10) on T2*-w MRIs following the first SVD (HR, 18.6; P= 0.0001).
  
  
  CONCLUSIONS
  Though a small sample size limited the power of our analyses, our findings suggest that a number of newly appeared dotHSs may be associated with SVD recurrence.
authors.affiliation: Department of Neurosurgery, Kushiro City General Hospital, Kushiro, Hokkaido, Japan. timaizum@d9.dion.ne.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Imaizumi
authors.forename: Toshimi
authors.initials: T
authors.lastname: Honma
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Horita
authors.forename: Masahiko
authors.initials: M
authors.lastname: Chiba
authors.forename: Maiko
authors.initials: M
authors.lastname: Kawamura
authors.forename: Kei
authors.initials: K
authors.lastname: Miyata
authors.forename: Ikuhide
authors.initials: I
authors.lastname: Kohama
authors.forename: Jun
authors.initials: J
authors.lastname: Niwa
mesh_terms: D000368:Aged; D002543:Cerebral Hemorrhage / Q000473:pathology; D005260:Female; D006485:Hemosiderin / Q000032:analysis*; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D018709:Statistics, Nonparametric; D020521:Stroke / Q000473:pathology*
chemical_list: D006485:Hemosiderin