Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position.
Novel oxazolidinone derivatives of the lead compound RBx 8700, containing methylene oxygen- and methylene sulfur-linked substituents at the C5-position, were synthesized. Antibacterial screening of these compounds against a panel of resistant and susceptible Gram-positive and fastidious Gram-negative bacteria gave compounds 2 and 4 as new antibacterial agents.
Rudra
Sonali
S
Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Laboratories Limited, Plot-20, Sector-18, Udyog Vihar, Gurgaon, India. sonali.rudra@ranbaxy.com
Sangita
Fnu
F
Gujrati
Arti
A
Pandya
Manisha
M
Bhateja
Pragya
P
Mathur
Tarun
T
Singhal
Smita
S
Rattan
Ashok
A
Salman
Mohammed
M
Das
Biswajit
B
D000081:Acetamides / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria; D000069349:Linezolid; D013058:Mass Spectrometry; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D023303:Oxazolidinones / Q000737:chemistry*; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry*; D013696:Temperature; D013859:Thiocarbamates / Q000737:chemistry
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D010879:Piperazines; D013859:Thiocarbamates; D000077489:Piperazine; D013455:Sulfur; D000069349:Linezolid; D008712:Methicillin