Evolution of chiral Lewis basic N-formamide as highly effective organocatalyst for asymmetric reduction of both ketones and ketimines with an unprecedented substrate scope.
L-Pipecolinic acid derived Lewis basic N-formamide has been developed as a first highly effective catalyst for the asymmetric reduction of aromatic and aliphatic ketones as well as aromatic and aliphatic ketimines in good to high enantioselectivity.
Zhou
Li
L
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.
Wang
Zhouyu
Z
Wei
Siyu
S
Sun
Jian
J
D002384:Catalysis; D005559:Formamides / Q000138:chemical synthesis / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry; D010084:Oxidation-Reduction; D010875:Pipecolic Acids / Q000737:chemistry*; D013237:Stereoisomerism
D005559:Formamides; D007097:Imines; D007659:Ketones; D009930:Organic Chemicals; D010875:Pipecolic Acids