title: A high-dose bortezomib neuropathy with sensory ataxia and myelin involvement.
abstract: Bortezomib, a proteasome inhibitor used in the treatment of multiple myeloma, is known to induce an axonal, dose-dependent neuropathy clinically characterized by pain, paresthesias, burning dysesthesias and numbness. In this study, we describe a patient treated with high-dose bortezomib whose main clinical feature was severe sensory ataxia. Electrodiagnostic studies showed, other than axonal changes, myelin involvement.
authors.affiliation: Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital "Spedali Civili", Brescia, Italy. filosto@med.unibs.it
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Filosto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rossi
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Pelizzari
authors.forename: Serena
authors.initials: S
authors.lastname: Buzio
authors.forename: Marta
authors.initials: M
authors.lastname: Tentorio
authors.forename: Laura
authors.initials: L
authors.lastname: Broglio
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Mancuso
authors.forename: Marianna
authors.initials: M
authors.lastname: Rinaldi
authors.forename: Mauro
authors.initials: M
authors.lastname: Scarpelli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Padovani
mesh_terms: D000368:Aged; D001259:Ataxia / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D001897:Boronic Acids / Q000627:therapeutic use*; D000069286:Bortezomib; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D009186:Myelin Sheath / Q000187:drug effects / Q000502:physiology*; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D011480:Protease Inhibitors / Q000627:therapeutic use*; D011719:Pyrazines / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology
chemical_list: D001897:Boronic Acids; D011480:Protease Inhibitors; D011719:Pyrazines; D000069286:Bortezomib