Ribosome-lamella complex precursors in acute monocytic leukemia: a study of 6 cases.
The ribosome-lamella complex (RLC) is a cylindrical structure composed of annular lamella associated particles, regarded as ribosomes, around a central core, which is best known in hairy cell leukemia. RLC has been presumed to originate from aggregating rER and ribosomes. Incomplete and maturing RLC structures have been called RLC precursors (pre-RLC). The present paper investigates the various architectural aspects of pre-RLC and the ultrastructural characteristics of the blasts in 6 cases of acute monocytic leukemia (M5) in which these structures occur. Blasts bearing pre-RLC contained irregular nuclei with less heterochromatin and a prominent nucleolus, and many cytoplasmic organelles in an abundant cytoplasm. The findings indicate that pre-RLC might result from an asymmetrical differentiation of organelles in blasts associated with expression of CD117 and CD56 but default of CD14 in M5.
Ru
Yong-xin
YX
Institute of Hematology & Blood Diseases Hospital, Peking Union Medical College, Tianjin, China. ruyongxin@126.com
Mi
Ying-chang
YC
Liu
Jin-hua
JH
Cui
Wen
W
Wang
Hui-jun
HJ
Zhao
Shi-xuan
SX
Jian-Xiang
Wang
W
D000293:Adolescent; D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D018870:Endoplasmic Reticulum, Rough / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism / Q000648:ultrastructure*; D007425:Intracellular Membranes / Q000378:metabolism / Q000648:ultrastructure*; D007948:Leukemia, Monocytic, Acute / Q000378:metabolism / Q000473:pathology*; D008297:Male; D046529:Microscopy, Electron, Transmission