title: A novel HLA-G allele (HLA-G*0108) with an alpha-3 domain amino acid change.
abstract: HLA-G non classical class I locus shows a comparatively low polymorphism. It encodes for tolerogenic HLA molecules that may be important in autoimmunity and transplant (and foetal) rejection control. HLA-G molecules give negative signals to Natural Killer and T lymphocytes. In the present paper, a new allele, HLA-G*08, is described, which may be useful for monitoring transplants and for HLA and disease studies.
authors.affiliation: Department of Immunology, Universidad Complutense, Madrid Regional Blood Center, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Moscoso
authors.forename: J I
authors.initials: JI
authors.lastname: Serrano-Vela
authors.forename: B
authors.initials: B
authors.lastname: Perez-Saborido
authors.forename: E
authors.initials: E
authors.lastname: Moreno
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz-Villena
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D006680:HLA Antigens / Q000737:chemistry / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D017434:Protein Structure, Tertiary / Q000235:genetics
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I