title: [The role of fine needle aspiration biopsy in differentiated thyroid carcinoma].
abstract: Fine needle aspiration biopsy (FNAB) in evaluation of nodular goiter generated a true revolution. It is generally assumed that the use of FNAB reduces the number of surgical procedures by 50%, while doubles the proportion of carcinoma in surgically treated patients. The aim of the study was to demonstrate the utility of FNAB in preoperative diagnosis of thyroid carcinoma.
  
  
  METHODS
  We have investigated 3240 patients with nodular goiter by FNAB (MGG stain and morphometrical analysis), followed by morphological examination in those who underwent surgery.
  
  
  RESULTS
  Globally, FNAB had a good sensitivity (77%) and specificity (95%), which made an accuracy of 92%, proving its diagnostic value. In follicular carcinoma (FC), where the cytological diagnostic cannot be certain, morphometry helped the diagnostic: mean cells diameter was significantly higher (p < 0.001) in FC (9.5 mm) vs. thyroid adenoma (8.6 mm).
  
  
  CONCLUSIONS
  With good statistical value, FNAB remain a useful preoperative diagnostic method.
authors.affiliation: Disciplina Morfopatologie, Facultatea de Medicină, Universitatea de Medicină si Farmacie "Gr. T. Popa", Iaşi.
authors.forename: Delia
authors.initials: D
authors.lastname: Ciobanu
authors.forename: Carmen
authors.initials: C
authors.lastname: Vulpoi
authors.forename: Niculina
authors.initials: N
authors.lastname: Florea
authors.forename: Maria-Christina
authors.initials: MC
authors.lastname: Ungureanu
authors.forename: Voichiţa
authors.initials: V
authors.lastname: Mogoş
authors.forename: Cipriana
authors.initials: C
authors.lastname: Stefănescu
authors.forename: V
authors.initials: V
authors.lastname: Rusu
authors.forename: Lidia
authors.initials: L
authors.lastname: Andriescu
authors.forename: A
authors.initials: A
authors.lastname: Grigorovici
authors.forename: E
authors.initials: E
authors.lastname: Zbranca
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology*; D018276:Carcinoma, Medullary / Q000473:pathology; D002291:Carcinoma, Papillary / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology*; D016606:Thyroid Nodule / Q000473:pathology