Cefpirome susceptibility in staphylococci isolates.
Cefpirome is a fourth-generation cephalosporin with an expanded spectrum against both Gram-negative and Gram-positive bacteria. The objective of this study was to evaluate the in vitro activity of cefpirome against staphylococci, clinical isolates. For comparison oxacillin was also tested.


METHODS
A total 434 isolates (coagulase-positive staphylococci, n = 268 and coagulase-negative staphylococci, n = 166) were tested. Susceptibility testing was performed using the Mueller-Hinton agar dilution method.


RESULTS
Cefpirome inhibited the majority of strains at 0.5-8 mg/l. Cefpirome had excellent activity against coagulase-negative staphylococci with 91.6% susceptibility. Except the coagulase-positive staphylococci, of the 268 isolates, 81.3% were cefpirome sensitive. Concerning oxacillin, 35.1% of coagulase-positive staphylococci isolates were resistant, comparative with 26.5% of the coagulase-negative staphylococci. A cross-resistance analysis showed the association of resistance between cefpirome and oxacillin.


CONCLUSIONS
Against staphylococci, cefpirome had the best activity when compared with the oxacillin.
Poiată
Antonia
A
Disciplina de Microbiologie, Facultatea de Farmacie, Universitatea de Medicină Si Farmacie "Gr. T. Popa", Iaşi.
Tuchiluş
Cristina
C
Bădicuţ
Ioana
I
Buiuc
D
D
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D003030:Coagulase / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests / Q000379:methods; D010068:Oxacillin / Q000494:pharmacology; D013210:Staphylococcus / Q000145:classification / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D000097572:Cefpirome
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D003030:Coagulase; D010068:Oxacillin; D000097572:Cefpirome