title: Comparative profile analysis of cognitive function in recent-onset and chronic patients with adolescent-onset schizophrenia.
abstract: We used z-transformed scores derived with reference to 43 healthy controls to compare cognitive profiles and selectivity of cognitive deficits in 19 recent-onset and 23 chronic patients with adolescent-onset schizophrenia. Relative to the controls, both patient groups were impaired in IQ, verbal memory and planning, but not visual memory or attention/mental flexibility. There were no significant differences in level or shape of cognitive profile between the two patient groups. Attention/mental flexibility emerged as a selective strength, and planning as a selective deficit, while verbal memory showed a trend towards selective impairment in the patients.
authors.affiliation: Institute of Psychiatry, Division of Psychological Medicine, London SE5 8AF, UK. e.kravariti@iop.kcl.ac.uk
authors.forename: Eugenia
authors.initials: E
authors.lastname: Kravariti
authors.forename: Robin G
authors.initials: RG
authors.lastname: Morris
authors.forename: Sophia
authors.initials: S
authors.lastname: Rabe-Hesketh
authors.forename: Robin M
authors.initials: RM
authors.lastname: Murray
authors.forename: Sophia
authors.initials: S
authors.lastname: Frangou
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000150:complications* / Q000453:epidemiology*