title: A single bout of brisk walking increases basal very low-density lipoprotein triacylglycerol clearance in young men.
abstract: Very low-density lipoprotein triacylglycerol (VLDL-TG) turnover rate was evaluated in the morning, 12 hours after a single bout of brisk walking (90 minutes at approximately 60% of VO2max; EXE), compared to a resting control period (CON) in 10 recreationally active men. VLDL-TG fractional catabolic rate was calculated from the decay in isotopic enrichment after a bolus injection of [2H5]glycerol. Plasma VLDL-TG concentration was 24% lower in the morning after the EXE trial compared to control (0.47+/-0.04 and 0.36+/-0.04 mmol L(-1), for CON and EXE, respectively; P<.01). Serum insulin (7.4+/-0.7 and 5.6+/-0.4 mIU L(-1), CON and EXE, respectively; P<.05) and plasma glucose (5.6+/-0.1 and 5.4+/-0.1 mmol/L, CON and EXE, respectively; P<.05) concentrations were also significantly lower in the EXE trial. Insulin sensitivity (homeostasis model assessment [HOMA] index) was improved by 27% in EXE compared with the CON trial (P<.05).VLDL-apolipoprotein B-100 and plasma fatty acid concentrations were similar in the two trials. Hepatic VLDL-TG secretion rates were not significantly affected by exercise (13.1+/-1.2 and 13.2+/-1.6 micromol.min(-1) for the CON and EXE trials, respectively), whereas VLDL-TG clearance rate increased by 36% (28.1+/-1.3 and 38.1+/-3.5 mL.min(-1) for the CON and EXE trials, respectively; P<.05). It is concluded that the decrease in fasting plasma VLDL-TG concentration observed 12 hours after brisk walking is related mainly to increased VLDL-TG clearance from plasma.
authors.affiliation: Department of Nutrition and Dietetics, Laboratory of Nutrition and Clinical Dietetics, Harokopio University, 176-71 Athens, Greece.
authors.forename: Yiannis E
authors.initials: YE
authors.lastname: Tsekouras
authors.forename: Tsekouras E
authors.initials: TE
authors.lastname: Yiannis
authors.forename: Amalia E
authors.initials: AE
authors.lastname: Yanni
authors.forename: Yanni E
authors.initials: YE
authors.lastname: Amalia
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Bougatsas
authors.forename: Bougatsas
authors.initials: B
authors.lastname: Dimitrios
authors.forename: Stavros A
authors.initials: SA
authors.lastname: Kavouras
authors.forename: Kavouras A
authors.initials: KA
authors.lastname: Stavros
authors.forename: Labros S
authors.initials: LS
authors.lastname: Sidossis
authors.forename: Sidossis S
authors.initials: SS
authors.lastname: Labros
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology; D001823:Body Composition / Q000502:physiology; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D004032:Diet; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D014280:Triglycerides / Q000378:metabolism*; D016138:Walking / Q000502:physiology*
chemical_list: D008079:Lipoproteins, VLDL; D014280:Triglycerides