title: Angiotensin-(1-7): pharmacology and new perspectives in cardiovascular treatments.
abstract: Many advances have been made in the cardiovascular field in the last several decades. Among them is the progress completed to date on the heptapeptide member of the renin-angiotensin system (RAS), angiotensin-(1-7) [Ang-(1-7)]. The peptide's beneficial actions against pathophysiological processes, such as cardiac arrhythmia, heart failure, hypertension, renal disease, preeclampsia, and even cancer are continuously being uncovered. This review encompasses the pharmacology of Ang-(1-7) and expounds upon the peptide's potential as a therapeutic agent against pathological processes both within and outside the cardiovascular continuum.
authors.affiliation: The Hypertension and Vascular Research Center, Wake Forest University Health Science Center, Winston-Salem, North Carolina 27157, USA. atrask@wfubmc.edu
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Trask
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Ferrario
mesh_terms: D000803:Angiotensin I / Q000494:pharmacology* / Q000502:physiology / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000188:drug therapy; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology* / Q000502:physiology / Q000627:therapeutic use; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000502:physiology
chemical_list: D000959:Antihypertensive Agents; D010446:Peptide Fragments; D000803:Angiotensin I; C118790:angiotensin I (1-7)