Low-dose aspirin use does not improve in vitro fertilization outcomes in poor responders.
OBJECTIVE
To assess if aspirin improves pregnancy outcome in patients undergoing in vitro fertilization (IVF) with a diagnosis of poor response.


METHODS
Retrospective cohort analysis.


METHODS
Academic private practice.


METHODS
1250 poor-responder patients undergoing IVF.


METHODS
Low-dose (81 mg) aspirin before and during an IVF cycle.


METHODS
Live-birth rate.


RESULTS
Patients taking 81 mg of aspirin had statistically significantly higher basal antral follicle counts, more days of stimulation, more ampules of gonadotropins used, higher peak estradiol levels, and more follicles that were > or = 14 mm in diameter on the day of human chorionic gonadotropin administration. There was a decrease in the overall fertilization rate for the patients taking aspirin. There was no difference in IVF outcome rates (implantation, pregnancy, loss, or live birth).


CONCLUSIONS
Patients with a diagnosis of poor response who were taking a regimen of 81 of mg aspirin showed an increase in many IVF stimulation parameters and a decrease in fertilization rates. No improvement secondary to 81-mg aspirin intake was found in IVF outcome rates.
Frattarelli
John L
JL
Reproductive Medicine Associates of New Jersey, Morristown, New Jersey. Electronic address: jfrattarelli@rmanj.com.
McWilliams
Grant D E
GDE
Tripler Army Medical Center, Honolulu, Hawaii.
Hill
Micah J
MJ
Tripler Army Medical Center, Honolulu, Hawaii.
Miller
Kathleen A
KA
Reproductive Medicine Associates of New Jersey, Morristown, New Jersey.
Scott
Richard T
RT
Reproductive Medicine Associates of New Jersey, Morristown, New Jersey.
D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D015331:Cohort Studies; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D006080:Ovarian Follicle / Q000187:drug effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies
D016861:Cyclooxygenase Inhibitors; D004958:Estradiol; D001241:Aspirin