Ergonovine-induced changes of coronary artery diameter in patients with nonsignificant coronary artery stenosis : relation with lipid profile.
OBJECTIVE
Serum cholesterol is positively associated with the risk of developing coronary heart disease. The aim of this study was to determine the relation between response of coronary arteries to ergonovine provocation and lipid profile in patients with nonsignificant coronary artery disease.


METHODS
105 patients (46 male, 59 female, mean age 52 +/- 8 years) with chest pain syndrome and nonsignificant coronary artery stenosis (< 50% diameter stenosis) were analyzed. Ergonovine test was performed at the end of diagnostic catheterization. Coronary spasm was defined as total or near total obstruction of the coronary artery. By quantitative coronary arteriography, changes of minimal luminal diameter (MLD) during ergonovine provocation were evaluated. Total cholesterol, LDL and HDL cholesterol, and triglycerides were measured.


RESULTS
There was a significant negative correlation between resting MLD and LDL cholesterol (r = -0.215; p = 0.034), and a significant positive correlation between MLD decrease provoked by ergonovine and total cholesterol (r = 0.275; p = 0.006), as well as LDL cholesterol (r = 0.284; p = 0.004), but not for HDL cholesterol and triglycerides (p = NS [not significant]).


CONCLUSIONS
In patients with nonsignificant coronary artery stenosis evaluated by ergonovine provocation, there was not only a significant negative correlation between MLD and LDL cholesterol, but also a positive correlation between coronary vasoconstriction induced by ergonovine provocation and both total and LDL cholesterol.
Nedeljkovic
Milan A
MA
Department of Cardiology, Diagnostic and Catheterization Laboratories, Institute for Cardiovascular Diseases, Clinical Center of Serbia, Belgrade, Serbia.
Ostojic
Miodrag C
MC
Beleslin
Branko D
BD
Nedeljkovic
Ivana
I
Milic
Natasa
N
Vukcevic
Vladan
V
Stojkovic
Sinisa
S
Saponjski
Jovica
J
Orlic
Dejan
D
Djordjevic-Dikic
Ana
A
Stepanovic
Jelena
J
Giga
Vojislav
V
Petrasinovic
Zorica
Z
Arandjelovic
Aleksandra
A
Beleslin
Biljana
B
Kanjuh
Vladimir
V
D008078:Cholesterol, LDL / Q000097:blood*; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000097:blood* / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000187:drug effects*; D004874:Ergonovine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
D008078:Cholesterol, LDL; D004874:Ergonovine