Effects of short-term moderate alcohol administration on oxidative stress and nutritional status in healthy males.
The effects of moderate amounts of different alcoholic beverages on oxidative stress and nutritional parameters were investigated in 40 healthy subjects. Ethanol 40 g/day was administered at the two main meals for 30 days by beer (group A), wine (group B) or spirit (group C); controls (group D) maintaned abstinence. Malondyaldeide (MDA), adenosine-triphosphate (ATP), reduced-glutathione (GSH), E-vitamin and nutritional status were evaluated at the start (T0) and the end (T1) of the study. At T1 controls did not present significant changes in the assessed parameters, while a significant increase of malondyaldeide (MDA) and a significant decrease of reduced-glutathione and E-vitamin in group A, B and C and of ATP in group C were observed. Fat mass (FM) increased slightly in group A and B and decreased in group C. Ethanol decreased antioxidant parameters and increased lipoperoxidation parameters. However some of these changes appeared attenuated when ethanol was consumed in beer or wine. Finally, short-term moderate ethanol intake appeared to influence the FM, although it was not able to significantly affect nutritional or body composition.
Addolorato
Giovanni
G
Institutes of Internal Medicine, Catholic University of Rome, L.go A. Gemelli 8, I-00168, Rome, Italy. g.addolorato@rm.unicatt.it
Leggio
Lorenzo
L
Ojetti
Veronica
V
Capristo
Esmeralda
E
Gasbarrini
Giovanni
G
Gasbarrini
Antonio
A
D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D000428:Alcohol Drinking; D000434:Alcoholic Beverages; D001515:Beer; D015992:Body Mass Index; D000431:Ethanol / Q000008:administration & dosage*; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009752:Nutritional Status / Q000187:drug effects*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D014810:Vitamin E / Q000097:blood; D014920:Wine
D014810:Vitamin E; D000431:Ethanol; D008315:Malondialdehyde; D000255:Adenosine Triphosphate; D005978:Glutathione