The role of apoptosis in autoantibody production.
Apoptosis is the physiologic process that guarantees the cellular exchange; after apoptosis the cellular remains are cleared by phagocytosis. In autoimmunity, some mechanisms in apoptosis fail and may result in disease. For instance, a failure in the Fas pathway during lymphoid ontogeny may allow the survival of autoimmune clones; equally the lack of clearance of apoptotic corps containing self-antigens may activate pre-existent auto-reactive clones and may result in autoantibody production. The role of apoptosis in autoimmunity is reviewed.
Herrera-Esparza
R
R
Herrera-van-Oostdam
D
D
López-Robles
E
E
Avalos-Díaz
E
E
D017209:Apoptosis / Q000276:immunology*; D001323:Autoantibodies / Q000096:biosynthesis*; D006801:Humans
D001323:Autoantibodies