title: Biscembranoids and their probable biogenetic precursor from the Hainan soft coral Sarcophyton tortuosum.
abstract: Five novel biscembranoids, ximaolides A-E (2-6), and their proposed biogenetic precursor, methyl tortuosoate (1), were isolated from the Hainan soft coral Sarcophyton tortuosum. The structures of compounds 1-6 were elucidated by spectroscopic methods, mainly NMR techniques. The relative stereochemistry of biscembranoids 2 and 6 was secured by X-ray diffraction analysis, whereas the relative configurations of chiral centers in compounds 1, 3, 4, and 5 have been suggested by both biogenetic considerations and NOESY experiments.
authors.affiliation: State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Zu Chong Zi Road 555, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Jia
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Yang
authors.forename: Ernesto
authors.initials: E
authors.lastname: Mollo
authors.forename: Margherita
authors.initials: M
authors.lastname: Gavagnin
authors.forename: Guido
authors.initials: G
authors.lastname: Cimino
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure
chemical_list: D004224:Diterpenes; C522143:methyl tortuosoate