Prevalence of BRCA1 expression in epithelial ovarian cancer: immunohistochemical study.
The 99 formalin fxed paraffin-embedded ovarian tissue specimens of Epithelial Ovarian Cancer (EOC) patients treated at the Gynecologic Oncology Unit, King Chulalongkorn Memorial Hospital between January 1, 1996 and December 31, 1999, were immuno-stained with BRCA antibody using the immunohistochemical method. According to the criteria for BRCA1 immunohistochemical evaluation (neoplastic nuclear staining more than 10%), 12 (12.1%) of the 99 specimens showed positive BRCA1 expression. No associated statistical significance between clinicopathological variables and BRCA expression was detected. Survival analysis was performed in 87 patients who were followed-up for more than 6 months and recent status were available. During a median follow-up of 43 months, median survival time was 46 months (range 6-84 months). No association between BRCA1 expression and survival outcomes was found (Disease free survival and overall survival) in the presented patients.
Sirisabya
Nakarin
N
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. drnakarin@hotmail.com
Manchana
Tarinee
T
Termrungreunglert
Wichai
W
Triratanachat
Surang
S
Charuruks
Navapun
N
Tresukosol
Damrong
D
D018572:Disease-Free Survival; D005260:Female; D015870:Gene Expression; D019398:Genes, BRCA1; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality; D016612:Paraffin Embedding; D016019:Survival Analysis