Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis.
The pre-B lymphoma in SL/Kh mice is a polygenic trait involving a number of host genes. In prelymphoma-stage bone marrow, transient pre-B cell expansion is induced by a host locus, Bomb1, and later followed by the emergence of a monoclonal population with a similar phenotype. To determine whether these pre-B cells represent precursors of lymphomas, we generated a congenic strain, NFS.SL/Kh-Bomb1 mice, by marker-assisted backcrossing to NFS. The congenic mice showed pre-B cell expansion, but pre-B lymphomas were not observed, even after 1 year of observation, irrespective of murine leukemia virus inoculation. Disturbed early B cell differentiation per se is not sufficient for SL/Kh lymphomagenesis.
Hiratsuka
Takuya
T
Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Tsuruyama
Tatsuaki
T
Kaszynski
Richard
R
Kometani
Kohei
K
Minato
Nagahiro
N
Nakamura
Takuro
T
Tamaki
Keiji
K
Hiai
Hiroshi
H
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology* / Q000821:virology; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002999:Clone Cells; D005434:Flow Cytometry; D015322:Gene Rearrangement, B-Lymphocyte; D009052:Leukemia Virus, Murine; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000821:virology; D051379:Mice; D020297:Mice, Congenic; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions / Q000235:genetics / Q000821:virology; D054448:Precursor Cells, B-Lymphoid / Q000166:cytology* / Q000821:virology