Hypotension and ST depression as a result of disulfiram ethanol reaction.
A case report of a 27-year-old man who developed significant hypotension and ischaemic ECG changes as a result of a disulfiram ethanol reaction. He was treated with intravenous fluids and norepinephrine, which has been advocated as the pressor agent of choice. This case highlights the potential dangers of disulfiram, a drug that can be beneficial in the short term, but not proven to improve long-term outcome in the treatment of alcoholism.
Milne
Helen J
HJ
Emergency Medicine, Kilmacolm, Renfrewshire, Scotland. helenjmilne@aol.com
Parke
Timothy R J
TR
D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D004221:Disulfiram / Q000009:adverse effects*; D004347:Drug Interactions; D004562:Electrocardiography; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D008297:Male
D000427:Alcohol Deterrents; D000431:Ethanol; D004221:Disulfiram