Medicinal flowers. XVI. New dammarane-type triterpene tetraglycosides and gastroprotective principles from flower buds of Panax ginseng.
The oligoglycoside fraction from the flower buds of Panax ginseng C. A. MEYER (Araliaceae) was found to show protective effects on ethanol-induced gastric mucosal lesions in rats. From the oligoglycoside fraction, new dammarane-type triterpene tetraglycosides, floralginsenosides M, N, O, and P, were isolated together with the major oligoglycosides ginsenoside Rd and Re. The structures of the new floralginsenosides were elucidated on the basis of chemical and physicochemical evidence. Ginsenoside Rd (protopanaxadiol 3,20-O-bisdesmoside) exhibited inhibitory effects on ethanol- and indomethacin-induced gastric mucosal lesions in rats.
Yoshikawa
Masayuki
M
Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan. myoshika@mb.kyoto-phu.ac.jp
Sugimoto
Sachiko
S
Nakamura
Seikou
S
Sakumae
Hayaka
H
Matsuda
Hisashi
H
D000818:Animals; D004195:Disease Models, Animal; D000431:Ethanol; D035264:Flowers / Q000737:chemistry*; D005765:Gastrointestinal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D007213:Indomethacin; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification; D000097669:Dammaranes
D000431:Ethanol; D005765:Gastrointestinal Agents; D006027:Glycosides; D007213:Indomethacin; D014315:Triterpenes; D000097669:Dammaranes