title: Radiology-Pathology Conference: pulmonary hyalinizing granuloma associated with lupus-like anticoagulant and Morvan's Syndrome.
abstract: Pulmonary hyalinizing granulomata are rare, noninfectious, fibrosing lesions of the lung, which can mimic metastatic disease radiographically. Their etiology is unknown, but they may be caused by an exaggerated immune response. We report the radiology, long clinical course, and pathology of a patient with pulmonary hyalinizing granuloma who presented with initially asymptomatic pulmonary nodules. Over a 10-year period, the patient developed multiple insidious autoimmune phenomena, including lupus anticoagulant, neuromyotonia, demyelinating sensorimotor polyneuropathy, and eventually, Morvan's syndrome. Such an association has not been previously published to our knowledge.
authors.affiliation: Department of Radiology, Winthrop-University Hospital, Mineola, NY, 11501, USA.
authors.forename: David I
authors.initials: DI
authors.lastname: Winger
authors.forename: Peter
authors.initials: P
authors.lastname: Spiegler
authors.forename: Terence K
authors.initials: TK
authors.lastname: Trow
authors.forename: Amit
authors.initials: A
authors.lastname: Goyal
authors.forename: Huiying
authors.initials: H
authors.lastname: Yu
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Yung
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Katz
mesh_terms: D017809:Fatal Outcome; D015769:Granuloma, Respiratory Tract / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D006818:Hyalin; D008137:Longitudinal Studies; D016682:Lupus Coagulation Inhibitor / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014057:Tomography, X-Ray Computed
chemical_list: D016682:Lupus Coagulation Inhibitor