Diagnosis and management of Thygeson's superficial punctate keratitis.
BACKGROUND
Thygeson's superficial punctate keratitis (TSPK) is a chronic disease with exacerbations and remissions over years to decades. Hallmarks of the disease include multiple, whitish-gray, intraepithelial corneal lesions with minimal or no conjunctival involvement. Although its exact etiology is controversial, TSPK has a genetic association with HLA-DR3, an antigen associated with immunogenic responses. Treatment of the disease varies depending on severity and can consist of artificial tears, corticosteroids, topical cyclosporine, or soft contact lenses.


METHODS
A 33-year-old African-American man presented with a complaint of a foreign body sensation in both eyes. After a thorough examination, a diagnosis of TSPK was made, and after appropriate management, complete resolution of the acute disease ensued.


CONCLUSIONS
A discussion of the case presented aims to provide clinicians with a clearer understanding of the clinical findings, etiology, and management of TSPK.
Duszak
Robert S
RS
Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA. bduszak@mac.com
D000328:Adult; D003315:Cornea / Q000473:pathology*; D019793:Fluorescein / Q000008:administration & dosage; D005456:Fluorescent Dyes / Q000008:administration & dosage; D005469:Fluorometholone / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007634:Keratitis / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D009883:Ophthalmic Solutions; D013997:Time Factors
D005456:Fluorescent Dyes; D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D005469:Fluorometholone; D019793:Fluorescein