title: Fumiquinones A and B, nematicidal quinones produced by Aspergillus fumigatus.
abstract: New nematicides named fumiquinones A (1) and B (2), together with spinulosin (3), LL-S490beta (4), and pseurotin A (5), were isolated from Aspergillus fumigatus and their structures were established by spectroscopic methods including 2D-NMR. Compound 1 showed effective nematicidal activities against Bursaphelenchus xylophilus and Pratylenchus penetrans without inhibiting plant growth except for lettuce seedlings. Compound 2 showed effective nematicidal activity against B. xylophilus, but had no inhibitory activity against P. penetrans. Compounds 3-5 showed effective nematicidal activities against B. xylophilus without any plant growth inhibition. Compounds 1-5 had no nematicidal activity against Caenorhabditis elegans. This is the first report of the nematicidal activities of compounds 3-5.
authors.affiliation: Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University, Koyama, Tottori, Japan.
authors.forename: Asami
authors.initials: A
authors.lastname: Hayashi
authors.forename: Shozo
authors.initials: S
authors.lastname: Fujioka
authors.forename: Manabu
authors.initials: M
authors.lastname: Nukina
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kawano
authors.forename: Atsumi
authors.initials: A
authors.lastname: Shimada
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kimura
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000378:metabolism* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000187:drug effects; D018545:Lactuca / Q000187:drug effects; D028223:Pinus / Q000187:drug effects; D011809:Quinones / Q000378:metabolism* / Q000494:pharmacology; D036226:Seedlings / Q000187:drug effects; D014431:Tylenchoidea / Q000187:drug effects
chemical_list: D000969:Antinematodal Agents; D011809:Quinones