title: Estimating active bone marrow dose from occupational exposure to uranium at a former gaseous diffusion plant.
abstract: Active bone marrow absorbed doses were estimated for 581 workers as part of a nested case-control study of multiple myeloma mortality at the Oak Ridge Gaseous Diffusion Plant (K-25). Uranium urinalysis results obtained by fluorometric and gross alpha measurements were available for about 20% of the 581 study subjects. These data were used to determine intakes of uranium as a result of occupational exposure during operation of the K-25 facility. Uranium solubility was inferred from the observed urinary excretion rate, job titles, and department codes. Data suggest that most study subjects were exposed to uranyl fluoride, a relatively soluble uranium compound. The median cumulative bone marrow dose determined for subjects with bioassay data was 0.06 mGy with a geometric standard deviation of 4.48. Subjects without bioassay data were assigned cumulative bone marrow dose based upon job titles and department codes.
authors.affiliation: Division of Surveillance, Hazard Evaluation, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH 45226, USA. JLAnderson@cdc.gov
authors.forename: J L
authors.initials: JL
authors.lastname: Anderson
authors.forename: H B
authors.initials: HB
authors.lastname: Spitz
authors.forename: J H
authors.initials: JH
authors.lastname: Yiin
mesh_terms: D001822:Body Burden; D001853:Bone Marrow / Q000737:chemistry / Q000528:radiation effects*; D006801:Humans; D016273:Occupational Exposure; D011829:Radiation Dosage; D014501:Uranium / Q000032:analysis* / Q000652:urine
chemical_list: D014501:Uranium