title: Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro.
abstract: Bioactive glasses (BAGs) of different compositions have been studied for decades for clinical use and they have found many dental and orthopaedic applications. Particulate BAGs have also been shown to have antibacterial properties. This large-scale study shows that two bioactive glass powders (S53P4 and 13-93) and a sol-gel derived material (CaPSiO II) have an antibacterial effect on 17 clinically important anaerobic bacterial species. All the materials tested demonstrated growth inhibition, although the concentration and time needed for the effect varied depending on the BAG. Glass S53P4 had a strong growth-inhibitory effect on all pathogens tested. Glass 13-93 and sol-gel derived material CaPSiO II showed moderate antibacterial properties.
authors.affiliation: Department of Medical Microbiology, University of Turku, Kiinamyllynkatu 13, Turku, Finland. oupale@utu.fi
authors.forename: Outi
authors.initials: O
authors.lastname: Leppäranta
authors.forename: Minna
authors.initials: M
authors.lastname: Vaahtio
authors.forename: Timo
authors.initials: T
authors.lastname: Peltola
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.forename: Leena
authors.initials: L
authors.lastname: Hupa
authors.forename: Mikko
authors.initials: M
authors.lastname: Hupa
authors.forename: Heimo
authors.initials: H
authors.lastname: Ylänen
authors.forename: Jukka I
authors.initials: JI
authors.lastname: Salonen
authors.forename: Matti K
authors.initials: MK
authors.lastname: Viljanen
authors.forename: Erkki
authors.initials: E
authors.lastname: Eerola
mesh_terms: D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001672:Biocompatible Materials; D005898:Glass; D013997:Time Factors
chemical_list: D000891:Anti-Infective Agents, Local; D001672:Biocompatible Materials