title: Relationship of adiponectin to serum paraoxonase 1.
abstract: Correlation of the plasma levels of insulin-sensitizing, anti-inflammatory and anti-atherosclerotic adiponectin with HDL has been demonstrated. However, its relation to HDL-bound paraoxonase 1 (PON1) has not been clarified. The association of serum PON1 activity with findings of metabolic syndrome was investigated in three age and sex-matched groups: (1) non-diabetic overweight subjects with BMI 28-39.9 kg/m(2) (n=25); (2) non-diabetic obese subjects with BMI>or=40 kg/m(2) (n=25); and (3) healthy, normal-weight controls (n=24). Of the parameters investigated, PON1 activity correlated positively with concentrations of HDL-C and adiponectin, and correlated negatively with BMI, waist circumference, systolic BP, levels of HbA(1C), and insulin, HOMA-IR, and TBARS. The positive correlation between adiponectin and PON1 remained significant even after adjustments for age, gender, BMI, blood pressure, HOMA-IR, HDL-C, LDL-C, and lipid peroxidation.
  
  
  CONCLUSIONS
  PON1 activity shows negative association with markers of metabolic syndrome. We demonstrate that adiponectin is an independent variable of serum PON1, which may contribute to the anti-atherosclerotic effect of adiponectin.
authors.affiliation: 1st Department of Medicine, School of Medicine, University of Pécs, H-7624 Pécs, Ifjúság út 13, Hungary. Laszlo.Bajnok@aok.pte.hu
authors.forename: Laszlo
authors.initials: L
authors.lastname: Bajnok
authors.forename: Eva
authors.initials: E
authors.lastname: Csongradi
authors.forename: Ildiko
authors.initials: I
authors.lastname: Seres
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Varga
authors.forename: Sara
authors.initials: S
authors.lastname: Jeges
authors.forename: Attila
authors.initials: A
authors.lastname: Peti
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Karanyi
authors.forename: Attila
authors.initials: A
authors.lastname: Juhasz
authors.forename: Emese
authors.initials: E
authors.lastname: Mezosi
authors.forename: Endre V
authors.initials: EV
authors.lastname: Nagy
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Paragh
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D050197:Atherosclerosis / Q000378:metabolism*; D001794:Blood Pressure; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000378:metabolism*; D050177:Overweight / Q000378:metabolism
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human