Anti-anxiety effect of ovary lipid extracted from Skipjack tuna (Katsuwonus pelamis) in rats.
Using an elevated plus-maze test, we evaluated anxiety level in rats given ovary lipid extracted from Skipjack tuna (Katsuwonus pelamis; OLS). The percentage of open time was significantly higher in rats given OLS than in rats in the control group, but lower than in rats given diazepam (1.0 mg/kg body weight). Based on this fact and findings about other indicators, this study showed that OLS does not have as fast-acting and strong an anti-anxiety effect as diazepam but that continuous ingestion of OLS causes an anti-anxiety effect in animals.
Ookawa
Katumasa
K
Industrial Research Institute of Shizuoka Prefecture, Aoi, Shizuoka, Japan.
Mochizuki
Kazuo
K
Shida
Eiji
E
Suzuki
Toshihiro
T
Suzuki
Toshihiro
T
Ooba
Tomoko
T
Matumoto
Toru
T
Hokari
Yoshinori
Y
Hashidume
Masayuki
M
Yokogoshi
Hidehiko
H
D000818:Animals; D014151:Anti-Anxiety Agents / Q000302:isolation & purification* / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy*; D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D008055:Lipids / Q000627:therapeutic use*; D010053:Ovary / Q000737:chemistry*; D051381:Rats; D013997:Time Factors; D014413:Tuna
D014151:Anti-Anxiety Agents; D008055:Lipids; D003975:Diazepam