Distribution of HSV-1 IgG antibodies by two methods comparing in Turkish atopic children.
Herpes Simplex Virus Type 1 (HSV-1) is a ubiquitous pathogen. Other than known diseases, HSV-1 may have an important role in the pathogenesis of atopy by causing immortality of th2 cells. From June 1st to July 31st 2006, seventy five blood samples were collected from atopic children referred to the allergy clinic of the hospital. The bloods samples were used to detect HSV-1 IgG antibodies by Enzyme-Linked Immunosorbent Assay and Virus Neutralization Test. HSV-1 IgG antibody seroprevalence in atopic children was found high, 62.6% by Enzyme-Linked Immunosorbent Assay and 57.3% by Virus Neutralization Test. Thus Virus Neutralization Test sensitivity was 92.15% and specificity was 100% regarding to the Enzyme-Linked Immunosorbent Assay technic. Although Enzyme-Linked Immunosorbent Assay was more sensitive than Virus Neutralization Test, there was no significant difference between two technics (p > 0.05) in detecting HSV-1 IgG antibodies in serum.
Artiran Igde
Fusun
F
Department of Family Medicine, School of Medicine, Ondokuz Mayis University, Samsun, Turkey. fartiran@yahoo.com
Igde
Mahir
M
Yazici
Zafer
Z
Okur Gumusova
Semra
S
Birinci
Asuman
A
Sancak
Recep
R
Ozturk
Fadil
F
D000914:Antibodies, Viral / Q000097:blood*; D045744:Cell Line, Tumor; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006561:Herpes Simplex / Q000453:epidemiology / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000821:virology*; D007074:Immunoglobulin G / Q000097:blood*; D009500:Neutralization Tests / Q000379:methods*; D012680:Sensitivity and Specificity; D016036:Seroepidemiologic Studies; D014421:Turkey
D000914:Antibodies, Viral; D007074:Immunoglobulin G