Kinetics studies on triacontanyl palmitate: a urease inhibitor.
The mechanism of inhibition of jack bean and Bacillus pasteurii ureases was investigated by triacontanyl palmitate (1) which is a long-chain fatty ester and has been isolated from Symplocos racemosa Roxb. Lineweaver-Burk, Dixon plots, and their secondary replots showed that 1 is a non-competitive inhibitor of these enzymes. K(i) values were found to be 60.03 +/- 1.72 and 88.23 +/- 0.31 microM against jack bean and B. pasteurii ureases, respectively.
Lodhi
Muhammad Arif
MA
Dr Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
Abbasi
Muhammad Athar
MA
Choudhary
Muhammad Iqbal
MI
Ahmad
Viqar Uddin
VU
D001407:Bacillus / Q000201:enzymology; D032449:Canavalia / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D019684:Magnoliopsida / Q000737:chemistry; D010168:Palmitates / Q000737:chemistry / Q000494:pharmacology*; D014510:Urease / Q000037:antagonists & inhibitors* / Q000378:metabolism
D004791:Enzyme Inhibitors; D005233:Fatty Alcohols; D010168:Palmitates; C047578:1-triacontanol; D014510:Urease