Does HPV-status 6-12 months after treatment of high grade dysplasia in the uterine cervix predict long term recurrence?
BACKGROUND
Women once treated for high grade cervical dysplasia have a high long term risk for developing new dysplasia or cancer.


OBJECTIVE
To investigate if human papilloma virus (HPV)-negativity after treatment of cervical dysplasia reduces the need for frequent long term follow up.


METHODS
Case/control study based on archival smears.


METHODS
Women with cervical intraepithelial neoplasi (CIN)2-3, treated for dysplasia and with recurrence of CIN2+ more than 2 years after treatment were compared with controls without recurrence, matched for age and date of treatment. High risk-HPV-DNA were analysed with PCR from two archival smears per woman. Mean follow up time was 14.6 years.


RESULTS
24% (45/189) of cases and 11% (43/378) of controls were HPV-positive in any of two smears. Odds ratio (OR)=2.5 (1.6-3.8).


CONCLUSIONS
HPV-status 6-12 months after treatment of high grade dysplasia is of limited value for the design of long term follow up.
Strander
Björn
B
Department of Obstetrics & Gynaecology, Sahlgrenska Academy, University of Göteborg, SE-413 45 Göteborg, Sweden. bjorn.strander@oc.gu.se
Ryd
Walter
W
Wallin
Keng-Ling
KL
Wärleby
Bengt
B
Zheng
Biying
B
Milsom
Ian
I
Gharizadeh
Baback
B
Pourmand
Nader
N
Andersson-Ellström
Agneta
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000821:virology*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D052163:Human papillomavirus 6 / Q000302:isolation & purification*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000821:virology; D014412:Tumor Virus Infections / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000628:therapy / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D014626:Vaginal Smears