Human serum albumin levels and cardiovascular risk factors in elderly Japanese-American men: the Honolulu Heart Program.
The objective of this study is to investigate the relationship between lowlevels of human serum albumin (HSA) and the incidence of coronary heart disease (CHD) in a cohort of elderly Japanese-American men. Using data from the Honolulu Heart Program's fourth examination (1991-1993), HSA levels of 998 Japanese American men aged 71-93 years was compared with plasma levels of fibrinogen, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, diastolic BP, BMI, and fasting blood glucose. HSA was significantly negatively associated with age and fibrinogen, and significantly positively associated with total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, diastolic BP, BMI and fasting blood glucose. After adjusting for age, tertiles of HSA were significantly positively associated with total cholesterol, HDL cholesterol and triglycerides, and significantly negatively associated with fibrinogen. Using multivariate stepwise regression, significant correlations were seen between HSA and fibrinogen, cholesterol, age, HDL cholesterol and triglycerides, and a borderline correlation was seen with systolic blood pressure. However, the model R-square for all variables was only 0.10. In conclusion, HSA levels are significantly associated with several traditional cardiovascular risk factors, particularly serum lipid levels.
Ha
Chung-Eun
CE
Department of Native Hawaiian Health, John A Burns School of Medicine, University of Hawai'i, Honolulu 96813, USA. chungeun@hawaii.edu
Masaki
Kamal H
KH
Petrovitch
Helen
H
Chen
Randi
R
Launer
Lenore
L
Bhagavan
Nadhipuram V
NV
Remaley
Alan T
AT
Curb
J David
JD
D000368:Aged; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000032:analysis; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology*; D005340:Fibrinogen / Q000032:analysis; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D008297:Male; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D012709:Serum Albumin; D005340:Fibrinogen; D002784:Cholesterol