title: Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia.
abstract: Four new indole alkaloids were obtained from two Kopsia species, 6-oxoleuconoxine (1) from the leaf extract of K. griffithii and kopsinitarine E (2), kopsijasminine (3), and kopsonoline (4) from the stem-bark extract of K. teoi. The structures of these alkaloids were determined using NMR and MS analysis. Kopsijasminine (3) showed moderate activity in reversing multidrug resistance in vincristine-resistant KB cells.
authors.affiliation: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Siew-Huah
authors.initials: SH
authors.lastname: Lim
authors.forename: Kooi-Mow
authors.initials: KM
authors.lastname: Sim
authors.forename: Zanariah
authors.initials: Z
authors.lastname: Abdullah
authors.forename: Osamu
authors.initials: O
authors.lastname: Hiraku
authors.forename: Masahiko
authors.initials: M
authors.lastname: Hayashi
authors.forename: Kanki
authors.initials: K
authors.lastname: Komiyama
authors.forename: Toh-Seok
authors.initials: TS
authors.lastname: Kam
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; D046948:Secologanin Tryptamine Alkaloids; D014750:Vincristine