title: The effect of fluoride gel on incipient carious lesions in a low-caries child population.
abstract: OBJECTIVE
  Secondary analyses were performed to study the cariostatic efficacy of semi-annual professional fluoride gel application on incipient carious lesions in low-caries children initially aged 9.5-11.5 years.
  
  
  METHODS
  Double-blind randomized controlled clinical trial.
  
  
  RESULTS
  The mean treatment effect of fluoride gel for enamel and dentinal caries lesions after 4 years' follow-up was 0.92 D(2,3)FS and 0.20 D(3)FS, respectively. When enamel lesions were included in the DFS count (i.e. D(2,3)FS), the preventive fraction (PF) showed borderline significance (23%; P = 0.05). No significant treatment effect of professionally applied fluoride gel was found for D(2,3)FS and D(3)FS scores of the second molars. The PF for D(2,3)FS of occlusal, approximal, buccal and lingual surfaces and for buccal and palatal pits and fissures differed not significantly.
  
  
  CONCLUSIONS
  Professionally applied fluoride gel showed no statistically significant caries-inhibiting effect on both enamel and dentine lesions in the permanent dentition of low-caries children.
authors.affiliation: Department of Preventive and Restorative Dentistry, Radboud University Nijmegen Medical Centre, The Netherlands. g.truin@dent.umcn.nl
authors.forename: Gert-Jan
authors.initials: GJ
authors.lastname: Truin
authors.forename: Martin
authors.initials: M
authors.lastname: van't Hof
mesh_terms: D002327:Cariostatic Agents / Q000008:administration & dosage*; D002648:Child; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D004311:Double-Blind Method; D005460:Fluorides, Topical / Q000008:administration & dosage*; D005782:Gels; D006801:Humans; D016896:Treatment Outcome
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D005782:Gels