In vitro induction of apoptosis in tumor cells by inactivated NDV and IAV.
We examined how Newcastle disease virus (NDV) and influenza A virus (IAV) inactivated by 5% formaldehyde, used either alone or in combination, can induce apoptosis in both HeLa and SP2/0 cells. Inactive NDV and IAV demonstrated enhanced rates of lysis in apoptotic tumor cells and greater antitumor effects when combined. Our study supports the argument that viral replication does not cause virally induced apoptosis.
Yang
ShuYan
S
Laboratory of Biochemistry and Molecular Biology, College of Biological Sciences, China, Agricultural University, Beijing, China.
Liu
WeiQuan
W
Cui
HuanXian
H
Sun
ShaoGuang
S
Wang
JiGui
J
D017209:Apoptosis; D045744:Cell Line, Tumor; D048430:Cell Shape; D005434:Flow Cytometry; D006801:Humans; D009980:Influenza A virus; D008854:Microscopy, Electron; D009369:Neoplasms / Q000473:pathology*; D009522:Newcastle disease virus; D038301:Virus Inactivation