Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia.
Four new indole alkaloids were obtained from two Kopsia species, 6-oxoleuconoxine (1) from the leaf extract of K. griffithii and kopsinitarine E (2), kopsijasminine (3), and kopsonoline (4) from the stem-bark extract of K. teoi. The structures of these alkaloids were determined using NMR and MS analysis. Kopsijasminine (3) showed moderate activity in reversing multidrug resistance in vincristine-resistant KB cells.
Lim
Siew-Huah
SH
Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Sim
Kooi-Mow
KM
Abdullah
Zanariah
Z
Hiraku
Osamu
O
Hayashi
Masahiko
M
Komiyama
Kanki
K
Kam
Toh-Seok
TS
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; D046948:Secologanin Tryptamine Alkaloids; D014750:Vincristine