title: Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum.
abstract: Three new germacrane sesquiterpenes, eupalinolides C-E (1-3), along with three known germacrane sesquiterpenes, eupalinolide A (4), eupalinolide B (5), and 3beta-acetoxy-8beta-(4'-hydroxytigloyloxy)-14-hydroxycostunolide (6), were isolated from Eupatorium lindleyanum. They were tested for cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines. The results showed that these compounds demonstrated potent cytotoxicity. The structures of the compounds were elucidated by means of (1)H and (13)C NMR spectroscopic analysis, including 2D NMR experiments.
authors.affiliation: Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, China.
authors.forename: N-Y
authors.initials: NY
authors.lastname: Yang
authors.forename: S-H
authors.initials: SH
authors.lastname: Qian
authors.forename: J-A
authors.initials: JA
authors.lastname: Duan
authors.forename: P
authors.initials: P
authors.lastname: Li
authors.forename: L-J
authors.initials: LJ
authors.lastname: Tian
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D036602:Eupatorium / Q000737:chemistry*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C525305:3,14-diacetoxy-8-(4'-acetoxytigloyloxy)-3,8,14-trihydroxy-1(10),4,11(13)-germacratrien-12,6-olide; C525306:3,14-diacetoxy-8-(4'-dehydrotigloyloxy)-3,8,14-trihydroxy-1(10),4,11(13)-germacratrien-12,6-olide; C525304:3-acetoxy-8-(4'-hydroxytigloyloxy)-3,8,14-trihydroxy-1(10),4,11(13)-germacratrien-12,6-olide; D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D045788:Sesquiterpenes, Germacrane