title: Use of dexmedetomidine in patients with trisomy 21 after cardiac surgery.
abstract: Children with trisomy 21 have a high incidence of congenital heart disease that frequently requires surgical repair. These patients often require multiple and higher dosage sedatives during the postoperative period. Dexmedetomidine is an alpha(2)-adrenergic receptor agonist that has sedative, analgesic, and anxiolytic properties. We report the successful use of dexmedetomidine in patients with trisomy 21 following surgical repair of congenital heart disease.
authors.affiliation: Children's Hospital of New Jersey, C-5, 201 Lyons Avenue, Newark, NJ 07112, USA. mkalyanaraman@sbhcs.com
authors.forename: M
authors.initials: M
authors.lastname: Kalyanaraman
authors.forename: J L
authors.initials: JL
authors.lastname: Costello
authors.forename: J P
authors.initials: JP
authors.lastname: Starr
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage* / Q000009:adverse effects; D001919:Bradycardia / Q000139:chemically induced; D006348:Cardiac Surgical Procedures; D002675:Child, Preschool; D020927:Dexmedetomidine / Q000008:administration & dosage* / Q000009:adverse effects; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006330:Heart Defects, Congenital / Q000209:etiology / Q000601:surgery*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000009:adverse effects; D007223:Infant; D008297:Male; D012189:Retrospective Studies
chemical_list: D018712:Analgesics, Non-Narcotic; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine