title: Ergonovine-induced changes of coronary artery diameter in patients with nonsignificant coronary artery stenosis : relation with lipid profile.
abstract: OBJECTIVE
  Serum cholesterol is positively associated with the risk of developing coronary heart disease. The aim of this study was to determine the relation between response of coronary arteries to ergonovine provocation and lipid profile in patients with nonsignificant coronary artery disease.
  
  
  METHODS
  105 patients (46 male, 59 female, mean age 52 +/- 8 years) with chest pain syndrome and nonsignificant coronary artery stenosis (< 50% diameter stenosis) were analyzed. Ergonovine test was performed at the end of diagnostic catheterization. Coronary spasm was defined as total or near total obstruction of the coronary artery. By quantitative coronary arteriography, changes of minimal luminal diameter (MLD) during ergonovine provocation were evaluated. Total cholesterol, LDL and HDL cholesterol, and triglycerides were measured.
  
  
  RESULTS
  There was a significant negative correlation between resting MLD and LDL cholesterol (r = -0.215; p = 0.034), and a significant positive correlation between MLD decrease provoked by ergonovine and total cholesterol (r = 0.275; p = 0.006), as well as LDL cholesterol (r = 0.284; p = 0.004), but not for HDL cholesterol and triglycerides (p = NS [not significant]).
  
  
  CONCLUSIONS
  In patients with nonsignificant coronary artery stenosis evaluated by ergonovine provocation, there was not only a significant negative correlation between MLD and LDL cholesterol, but also a positive correlation between coronary vasoconstriction induced by ergonovine provocation and both total and LDL cholesterol.
authors.affiliation: Department of Cardiology, Diagnostic and Catheterization Laboratories, Institute for Cardiovascular Diseases, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Milan A
authors.initials: MA
authors.lastname: Nedeljkovic
authors.forename: Miodrag C
authors.initials: MC
authors.lastname: Ostojic
authors.forename: Branko D
authors.initials: BD
authors.lastname: Beleslin
authors.forename: Ivana
authors.initials: I
authors.lastname: Nedeljkovic
authors.forename: Natasa
authors.initials: N
authors.lastname: Milic
authors.forename: Vladan
authors.initials: V
authors.lastname: Vukcevic
authors.forename: Sinisa
authors.initials: S
authors.lastname: Stojkovic
authors.forename: Jovica
authors.initials: J
authors.lastname: Saponjski
authors.forename: Dejan
authors.initials: D
authors.lastname: Orlic
authors.forename: Ana
authors.initials: A
authors.lastname: Djordjevic-Dikic
authors.forename: Jelena
authors.initials: J
authors.lastname: Stepanovic
authors.forename: Vojislav
authors.initials: V
authors.lastname: Giga
authors.forename: Zorica
authors.initials: Z
authors.lastname: Petrasinovic
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Arandjelovic
authors.forename: Biljana
authors.initials: B
authors.lastname: Beleslin
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kanjuh
mesh_terms: D008078:Cholesterol, LDL / Q000097:blood*; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000097:blood* / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000187:drug effects*; D004874:Ergonovine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D008078:Cholesterol, LDL; D004874:Ergonovine