title: Premature carotid artery disease in long-term survivors of childhood cancer treated with neck irradiation: a series of 5 cases.
abstract: BACKGROUND
  Follow-up studies find an increase in stroke and carotid artery disease incidence in adult cancer patients treated with neck irradiation. These radiation-related late effects are now being detected in young adult survivors of childhood cancer.
  
  
  METHODS
  This report includes 5 pediatric cancer survivors, ages 23 to 40, who presented with advanced carotid artery stenosis 17 to 36 years after receiving neck irradiation. Radiation doses ranged from 3900 to 7350 cGy. Three of the 5 experienced a stroke.
  
  
  CONCLUSIONS
  Prevalence and risk factors associated with premature carotid artery disease after neck irradiation need to be investigated in childhood cancer survivors.
authors.affiliation: Department of Pediatrics, Division of Hematology-Oncology, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. kmeeske@chla.usc.edu
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Meeske
authors.forename: Marvin D
authors.initials: MD
authors.lastname: Nelson
authors.forename: Robert S
authors.initials: RS
authors.lastname: Lavey
authors.forename: Sarah
authors.initials: S
authors.lastname: Gee
authors.forename: Mary B
authors.initials: MB
authors.lastname: Nelson
authors.forename: Leslie
authors.initials: L
authors.lastname: Bernstein
authors.forename: Fred
authors.initials: F
authors.lastname: Weaver
authors.forename: Stuart
authors.initials: S
authors.lastname: Siegel
mesh_terms: D000328:Adult; D002340:Carotid Artery Diseases / Q000209:etiology*; D006801:Humans; D008297:Male; D009333:Neck / Q000528:radiation effects*; D009369:Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects*; D017741:Survivors