title: Regulation of membrane fusion in synaptic excitation-secretion coupling: speed and accuracy matter.
abstract: Unlike most other secretory processes, neurotransmitter release at chemical synapses is extremely fast, tightly regulated, spatially restricted, and dynamically adjustable at the same time. In this review, we focus on recent discoveries of molecular and cell biological processes that determine how fusion competence of vesicles is achieved and controlled in order to suit the specific requirements of synaptic transmitter release with respect to speed and spatial selectivity.
authors.affiliation: Max-Planck-Institut für Experimentelle Medizin, Abteilung Molekulare Neurobiologie, Hermann-Rein-Strasse 3, D-37075 Göttingen, Deutschland. wojcik@em.mpg.de
authors.forename: Sonja M
authors.initials: SM
authors.lastname: Wojcik
authors.forename: Nils
authors.initials: N
authors.lastname: Brose
mesh_terms: D000818:Animals; D005089:Exocytosis / Q000502:physiology; D006801:Humans; D008561:Membrane Fusion / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism* / Q000502:physiology*; D050600:SNARE Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000378:metabolism* / Q000502:physiology*; D013572:Synaptic Vesicles / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents; D050600:SNARE Proteins