title: A novel perspective on natural therapeutic approaches in glaucoma therapy.
abstract: Glaucoma is becoming recognised as a condition for which not only elevated intraocular pressure (IOP), but also non-pressure-dependent risk factors, are responsible. Better knowledge of the pathogenesis has opened up new therapeutic approaches that are often referred to as non-IOP-lowering treatment. These new avenues of treatment, some of which are still under investigation, include agents that can improve vascular regulation and blood flow to the eye and reduce oxidative stress. Vascular regulation can be improved systemically with magnesium. Dark chocolate and omega-3-fatty acids can also improve blood flow regulation. Oxidative stress at mitochondrial level can be reduced by gingko. Polyphenolic flavonoids (tea, coffee and red wine), anthocyanosides, ubiquinone and melatonin have antioxidant properties, and heat-shock proteins can be induced naturally by the use of sauna baths. Future intensive studies on the effect of these compounds may open up a new therapeutic era in glaucoma.
authors.affiliation: University Eye Clinic Basel, Mittlere Strasse 91, PO Box, CH-4031 Basel, Switzerland.
authors.forename: Maneli
authors.initials: M
authors.lastname: Mozaffarieh
authors.forename: Josef
authors.initials: J
authors.lastname: Flammer
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage; D003069:Coffee; D000529:Complementary Therapies / Q000379:methods / Q000639:trends*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D020441:Ginkgo biloba; D005901:Glaucoma / Q000175:diagnosis / Q000178:diet therapy / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology
chemical_list: D000975:Antioxidants; D003069:Coffee; D015525:Fatty Acids, Omega-3