title: Evolution of the Groucho/Tle gene family: gene organization and duplication events.
abstract: The Groucho/Tle family of corepressor proteins has important roles in development and in adult tissue in both Protostomes and Deuterostomes. In Drosophila, a single member of this family has been identified. Unlike in Protostomes, most Deutrostomes contain more than two full-length Tle genes. In this study, I analyse the genomic organization and phylogenetic relationship between the long and short forms of the Groucho/Tle family members in Chordata. The genomic location and sequence similarities suggest that Aes/Grg5 and Tle6/Grg6 arose from duplication of the Tle2 gene; each evolved independently and acquired new functions as negative regulators of the other Tle proteins. Based on these data, a model for Groucho/Tle gene evolution is proposed.
authors.affiliation: Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria. bajoghli@immunbio.mpg.de
authors.forename: Baubak
authors.initials: B
authors.lastname: Bajoghli
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D043344:Chordata / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D020440:Gene Duplication; D014644:Genetic Variation; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D012097:Repressor Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D029721:Drosophila Proteins; D012097:Repressor Proteins; C121960:E(spl)m7-HLH protein, Drosophila; C091023:gro protein, Drosophila