title: Enaminones: Exploring additional therapeutic activities.
abstract: Enaminones, enamines of beta-dicarbonyl compounds, have been known for many years. Their early use has been relegated to serving as synthetic intermediates in organic synthesis and of late, in pharmaceutical development. Recently, the therapeutic potential of these entities has been realized. This review provides the background and current research in this area with emphasis of these agents as potential anticonvulsants, their proposed mechanisms of action, and as potential modulators of multidrug resistance (MDR).
authors.affiliation: Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait.
authors.forename: Ivan O
authors.initials: IO
authors.lastname: Edafiogho
authors.forename: Samuel B
authors.initials: SB
authors.lastname: Kombian
authors.forename: Kethireddy V V
authors.initials: KV
authors.lastname: Ananthalakshmi
authors.forename: Noha N
authors.initials: NN
authors.lastname: Salama
authors.forename: Natalie D
authors.initials: ND
authors.lastname: Eddington
authors.forename: Tiffany L
authors.initials: TL
authors.lastname: Wilson
authors.forename: Mariano S
authors.initials: MS
authors.lastname: Alexander
authors.forename: Patrice L
authors.initials: PL
authors.lastname: Jackson
authors.forename: Clive D
authors.initials: CD
authors.lastname: Hanson
authors.forename: K R
authors.initials: KR
authors.lastname: Scott
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D000588:Amines / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000378:metabolism; D018360:Crystallography, X-Ray; D018432:Drug Resistance, Multiple / Q000187:drug effects* / Q000235:genetics; D004827:Epilepsy / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D021281:Quantitative Structure-Activity Relationship; D009435:Synaptic Transmission / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000588:Amines; D000927:Anticonvulsants; D005680:gamma-Aminobutyric Acid