[Pharmacological treatment of neurogenic detrusor hyperactivity: intrathecal drugs].
Intrathecal clonidine has been tested in spinal cord injury patients not supporting or resistant to anticholinergic drugs. Although the acute effect of clonidine on urodynamic parameters was satisfactory, cardiovascular adverse effects limited the long-term efficacy of this treatment. Intrathecal baclofen has a limited effect on overactive bladder in patients with spinal spasticity, but can modify the quality of erections and induce an incapacity to trigger ejaculation by vibratory penile stimulation.
Denys
P
P
Service de Médecine Physique et de Réadaptation, Raymond Poincaré, Université Versailles Saint-Quentin en Yvelines, Bordeaux, France. pierre.denys@rpc.aphp.fr
Schneider
A Even
AE
Remy-Neris
O
O
Ben-Smail
D
D
Chartier-Kastler
E
E
Ruffion
A
A
Bussel
B
B
D001418:Baclofen / Q000008:administration & dosage / Q000627:therapeutic use*; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D007172:Erectile Dysfunction / Q000209:etiology; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology*; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000209:etiology; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000209:etiology
D001418:Baclofen; D003000:Clonidine