BCP ceramic microspheres as drug delivery carriers: synthesis, characterisation and doxycycline release.
Resorbable ceramics such as biphasic calcium phosphates (BCP) are ideal candidates as drug delivery systems. The BCP ceramic is based on the optimum balance of the most stable hydroxyapatite (HA) phase and more soluble tricalcium phosphate phase (TCP). Doxycycline is a broad-spectrum antibiotic used for the local treatment of periodontitis. The development of BCP microspheres and its release kinetics with doxycycline have been studied. The BCP ceramic powder were prepared by microwave processing and characterised by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) methods. The BCP microspheres were formed by liquid immiscibility effect using gelatin and paraffin oil. Difference in the morphology of the microspheres as a function of gelatin content has been observed. Scanning electron microscope indicated spherical and porous morphology of the microspheres. Drug incorporation was studied at varying pH and the pH 7 was found to be optimal for drug loading. Release pattern tend to depend on the morphology of BCP microspheres. An optimum release of 80% drug has been observed for BCP microsphere with HA:TCP=65:35 ratio. The surface area measurement results also correlate with drug release obtained.
Victor
Sunita Prem
SP
Department of Metallurgical and Materials Engineering, Indian Institute of Technology, Madras 600036, India.
Kumar
T S Sampath
TS
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D001672:Biocompatible Materials; D002130:Calcium Phosphates / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D004318:Doxycycline / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D005780:Gelatin / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008863:Microspheres; D010232:Paraffin / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D010232:Paraffin; D005780:Gelatin; C020243:calcium phosphate; D004318:Doxycycline