title: Prenylated xanthones from the root bark of Cudrania tricuspidata.
abstract: Four new prenylated xanthones, cudratricusxanthones J-M (1-4), were isolated from the CH2Cl2-soluble extract of the root bark of Cudrania tricuspidata, along with four known prenylated xanthones, isocudraxanthone K (5), cudraxanthone C (6), cudratricusxanthone A (7), and cudraxanthone L (8), and three known prenylated flavonoids, cudraflavone A (9), cudraflavanone A (10), and cudraflavone B (11). The structures of compounds 1-4 were elucidated using spectroscopic methods. Cudratricusxanthone A (7), cudraflavanone A (10), and cudraflavone B (11) showed moderate inhibitory effects on mouse brain monoamine oxidase (MAO) with IC50 values of 88.3, 89.7, and 80.0 microM, respectively.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, Korea.
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Hwang
authors.forename: Seong Su
authors.initials: SS
authors.lastname: Hong
authors.forename: Xiang Hua
authors.initials: XH
authors.lastname: Han
authors.forename: Ji Sang
authors.initials: JS
authors.lastname: Hwang
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Heesoon
authors.initials: H
authors.lastname: Lee
authors.forename: Yeo Pyo
authors.initials: YP
authors.lastname: Yun
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Jai Seup
authors.initials: JS
authors.lastname: Ro
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D051379:Mice; D015394:Molecular Structure; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029586:Moraceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D008996:Monoamine Oxidase Inhibitors; D044004:Xanthones