Histological evaluation of apatite cement containing atelocollagen.
Tissue response to apatite cement (AC) containing atelocollagen (AC (ate)) was evaluated using conventional AC (c-AC) as a control material. At one week, the only difference between AC (ate) and c-AC was found in the soft tissue response. With c-AC, a moderate inflammatory response was exhibited: small particles of c-AC were scattered in the cutaneous tissue and many foreign body giant cells were aggregated around the scattered c-AC, whereas AC (ate) showed only a slight inflammatory response with few foreign body giant cells. In terms of bone tissue response, difference between AC (ate) and c-AC was observed at four weeks. New bone formation was observed along the cement at the edge of the pre-existing cortical bone in both c-AC and AC (ate). However, in the case of AC (ate), more abundant and thicker new bone was formed along the cement in the bone marrow when compared with c-AC.
Takechi
Masaaki
M
Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. takechi@hiroshima-u.ac.jp
Miyamoto
Youji
Y
Ishikawas
Kunio
K
Momota
Yukihiro
Y
Yuasa
Tetsuya
T
Tatehara
Seiko
S
Takano
Hideyuki
H
Minamiguchi
Shiho
S
Nagayama
Masaru
M
D000818:Animals; D001843:Bone Cements / Q000494:pharmacology* / Q000633:toxicity; D001861:Bone Regeneration / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects; D002417:Cattle; D003094:Collagen / Q000494:pharmacology* / Q000633:toxicity; D005549:Foreign-Body Reaction / Q000209:etiology; D006882:Hydroxyapatites / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D040521:Subcutaneous Tissue / Q000187:drug effects; D014961:X-Ray Diffraction
D001843:Bone Cements; D006882:Hydroxyapatites; C059821:atelocollagen; C475044:hydroxyapatite cement; D003094:Collagen