title: Spectrophotometric simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form.
abstract: A new simple, economical, rapid, precise and accurate method for simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form has been developed. The method is based on ratio spectra derivative spectrophotometry. The amplitudes in the first derivative of the corresponding ratio spectra at 231nm (minima) and 260nm were selected to determine rabeprazole sodium and itopride hydrochloride, respectively. The method was validated with respect to linearity, precision and accuracy.
authors.affiliation: Department of Pharmaceutical Analysis, A.I.S.S.M.S. College of Pharmacy, Kennedy Road, Near R.T.O., Pune 411 001, Maharashtra, India.
authors.forename: Shweta S
authors.initials: SS
authors.lastname: Sabnis
authors.forename: Nilesh D
authors.initials: ND
authors.lastname: Dhavale
authors.forename: Vijay Y
authors.initials: VY
authors.lastname: Jadhav
authors.forename: Santosh V
authors.initials: SV
authors.lastname: Gandhi
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000032:analysis*; D001549:Benzamides / Q000032:analysis*; D001593:Benzyl Compounds / Q000032:analysis*; D002214:Capsules / Q000737:chemistry*; D064750:Rabeprazole; D012015:Reference Standards; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001549:Benzamides; D001593:Benzyl Compounds; D002214:Capsules; D012996:Solutions; D064750:Rabeprazole; C102254:itopride