title: PGE-1 in replantation and free tissue transfer: early preliminary experience.
abstract: Experimental and clinical trials demonstrate the vascular, anti-ischemic and tissue protective effects of PGE1, which has been used for many years in different macrovascular diseases. However, few reports have addressed its potential use in microvascular surgery. The authors share their early experience with PGE1 in replantations and free tissue transfers. Considering its established benefits and minimal adverse reactions, PGE1 might be included as a first-line medication in the antithrombotic pharmacologic treatment in replantation and free flap surgery. However, the overall clinical efficacy and safety of PGE1 in microvascular surgery remains to be determined in larger, prospective clinical trials.
authors.affiliation: Plastic and Reconstructive Surgery Service, Fundación Jiménez Díaz (Clínica de la Concepción), Madrid, Spain. jmrv2020@yahoo.com
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodríguez Vegas
authors.forename: María Elena
authors.initials: ME
authors.lastname: Ruiz Alonso
authors.forename: Pedro Pablo
authors.initials: PP
authors.lastname: Terán Saavedra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use*; D000673:Amputation, Traumatic; D002648:Child; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D005383:Finger Injuries / Q000601:surgery; D005385:Fingers / Q000601:surgery; D006230:Hand Injuries / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012092:Replantation; D013524:Surgical Flaps; D013933:Thumb / Q000293:injuries* / Q000601:surgery*
chemical_list: D005343:Fibrinolytic Agents; D000527:Alprostadil