title: A new Hantaan-like virus in rodents (Apodemus peninsulae) from Northeastern China.
abstract: Lung tissue samples of 76 Korean field mice (Apodemus peninsulae) collected from northeastern China bordering with Far East Russia and Korea were detected for hantavirus partial M-segment or entire S-segment sequences by RT-PCR and 481-nt mitochondrial DNA fragment of the rodents. Four A. peninsulae mice were found positive for partial M-segment of hantavirus. Sequence analyses of partial M-segment or/and entire S-segment of the hantaviruses revealed that three were closely related to Hantaan virus (HTNV) strain 76-118. One new variant of HTNV-like virus designated as "Jilin-AP06" was much different from other rodent-borne hantavirus from China, and clustered with Amur (AMR) virus strains, which represent a distinct genetic lineage. These findings imply that hantavirus Jililn-AP06 strain from A. peninsulae is a new record of rodent-borne AMR virus in China. A. peninsulae might be a natural carrier of two distinct hantaviruses, AMR virus and HTNV in China.
authors.affiliation: Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, PR China.
authors.forename: Jia-Fu
authors.initials: JF
authors.lastname: Jiang
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Yao
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Wu
authors.forename: Shu-Qing
authors.initials: SQ
authors.lastname: Zuo
authors.forename: Lin
authors.initials: L
authors.lastname: Zhan
authors.forename: Pan-He
authors.initials: PH
authors.lastname: Zhang
authors.forename: Wu-Chun
authors.initials: WC
authors.lastname: Cao
mesh_terms: D000818:Animals; D002681:China; D018063:Hantaan virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D008168:Lung / Q000821:virology; D051379:Mice; D008969:Molecular Sequence Data; D051189:Murinae / Q000821:virology*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D012367:RNA, Viral