Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.
Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.
Zainuddin
Elmi N
EN
Institute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany.
Mentel
Renate
R
Wray
Victor
V
Jansen
Rolf
R
Nimtz
Manfred
M
Lalk
Michael
M
Mundt
Sabine
S
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005858:Germany; D009980:Influenza A virus / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D046931:Microcystis / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000998:Antiviral Agents; D047630:Depsipeptides; C522137:ichthyopeptin A; C522138:ichthyopeptin B