title: Carcinoma in a mixed mammary tumor in a llama (Lama glama).
abstract: A 13-year-old female llama was presented to the referring veterinarian for swelling and firmness of the right rear mammary gland, for a duration of 2 months, which had been unresponsive to antibiotics. A formalin-fixed wedge biopsy specimen from the affected quarter was submitted to Purdue University Animal Disease Diagnostic Laboratory for histopathology. Histopathologic examination revealed tubulopapillary acinar or solid nest-like clusters of neoplastic epithelial cells surrounded by whorls and sheets of proliferative myoepithelial cells. Histologic criteria for malignancy observed in neoplastic epithelial cells included marked cellular and nuclear atypia, high mitotic index, and numerous bizarre mitoses. The presence of osseous metaplasia in the proliferative mesenchymal component justified classification as a mixed tumor. Positive immunohistochemical staining of neoplastic epithelial cells with anticytokeratin antibody, and proliferative spindloid cells with antiviemtin and antismooth muscle actin antibodies supported the histopathologic diagnosis. The llama was in good health after about 1 year of initial presentation, and metastasis to regional lymph nodes was not reported. Mammary neoplasia is rare in camelids. To the authors' knowledge, this is the first report of a carcinoma in a mixed mammary tumor in a llama.
authors.affiliation: Animal Disease Diagnostic Laboratory Purduce University, West Lafayette, IN 47907, USA. dsingh@purdue.edu
authors.forename: Dinesh S
authors.initials: DS
authors.lastname: Bangari
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Stevenson
mesh_terms: D000818:Animals; D002161:Camelids, New World; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008321:Mammary Glands, Animal / Q000473:pathology; D015674:Mammary Neoplasms, Animal / Q000175:diagnosis* / Q000473:pathology