Elevated anti-sulfatide antibodies in Guillain-Barré syndrome in T cell depleted at end-stage AIDS.
A 38-year-old man developed the Guillain-Barré syndrome (GBS) associated with untreated end-stage AIDS and CD4+ lymphocyte count of 3 cells/mm(3). The patient had serum high titer anti-sulfatide antibodies and responded well to infusion of immunoglobulin. The data suggest that elevated levels of anti-sulfatide antibodies may play a role in the pathogenesis of GBS in this patient, although a direct neurotropic effect of HIV virus cannot be excluded.
Souayah
Nizar
N
Department of Neurology & Neuroscience, UMDNJ-New Jersey Medical School, Newark, NJ 07103, United States. souayani@umdnj.edu <souayani@umdnj.edu>
Mian
Nimer F
NF
Gu
Yajuan
Y
Ilyas
Amjad A
AA
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000473:pathology*; D000328:Adult; D000906:Antibodies / Q000097:blood*; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D002855:Chromatography, Thin Layer / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D020275:Guillain-Barre Syndrome / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D010525:Peripheral Nerves / Q000503:physiopathology; D013433:Sulfoglycosphingolipids / Q000276:immunology*
D000906:Antibodies; D013433:Sulfoglycosphingolipids