A young male with paraplegia, massive cervical adenopathy and nondiagnostic biopsy specimens.
An 18-year-old man presenting with paraplegia due to spinal epidural infiltration at D6-D7 underwent laminectomy and spinal decompression followed by near-complete resolution of neurological symptoms; but this resolution was followed by progressively enlarging cervical lymph nodes. Leucocytosis, an elevated erythrocyte sedimentation rate, a marked polyclonal hypergammaglobulinemia and a moderate hepatosplenomegaly were found. The diagnosis of sinus histiocytosis with massive lymphadenopathy (SHML), also known as Rosai-Dorfman disease was established histologically by lymph node biopsy about 2 years after presentation.
Mitra
S
S
Department of Respiratory Medicine, Institute of Postgraduate Medical Education and Research and S.S.K.M. Hospital, Kolkata.
Kundu
S
S
Majumdar
A
A
Pattari
S K
SK
D000293:Adolescent; D001706:Biopsy; D004487:Edema / Q000209:etiology*; D015618:Histiocytosis, Sinus / Q000175:diagnosis*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D010264:Paraplegia / Q000209:etiology*