title: Long-term use of nebulized human recombinant DNase1 in two siblings with primary ciliary dyskinesia.
abstract: Primary ciliary dyskinesia (PCD) is characterized by ultra-structural defects of the cilia. In this report, we describe the long-term use of nebulized dornase alfa in two siblings with PCD. This is the first report of long-term use of dornase alfa in PCD.
authors.affiliation: Faculty of Medicine, Cairo University, Children's Hospital, Cairo, Egypt.
authors.forename: Nisreen M
authors.initials: NM
authors.lastname: El-Abiad
authors.forename: Shelley
authors.initials: S
authors.lastname: Clifton
authors.forename: Samya Z
authors.initials: SZ
authors.lastname: Nasr
mesh_terms: D000293:Adolescent; D003850:Deoxyribonuclease I / Q000008:administration & dosage*; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D007619:Kartagener Syndrome / Q000188:drug therapy*; D008134:Long-Term Care / Q000379:methods; D008297:Male; D009330:Nebulizers and Vaporizers; D016896:Treatment Outcome
chemical_list: C085693:DNASE1 protein, human; D003850:Deoxyribonuclease I