title: Prototype laser-activated shape memory polymer foam device for embolic treatment of aneurysms.
abstract: Conventional embolization of cerebral aneurysms using detachable coils is time-consuming and often requires retreatment. These drawbacks have prompted the development of new methods of aneurysm occlusion. We present the fabrication and laser deployment of a shape memory (SMP) polymer expanding foam device. Data acquired in an in vitro basilar aneurysm model with and without flow showed successful treatment, with the flow rate affecting foam expansion and the temperature at the aneurysm wall.
authors.affiliation: Lawrence Livermore National Laboratory, Applied Physics and Biophysics Division, Livermore, California 94550, USA. maitland1@llnl.gov
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Maitland
authors.forename: Ward
authors.initials: W
authors.lastname: Small
authors.forename: Jason M
authors.initials: JM
authors.lastname: Ortega
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Buckley
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rodriguez
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hartman
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Wilson
mesh_terms: D000783:Aneurysm / Q000628:therapy*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000528:radiation effects / Q000627:therapeutic use; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods*; D005740:Gases / Q000737:chemistry; D006801:Humans; D007834:Lasers; D008422:Materials Testing; D010865:Pilot Projects; D011108:Polymers / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use*
chemical_list: D001672:Biocompatible Materials; D005740:Gases; D011108:Polymers