title: Paclitaxel and cisplatin with concurrent radiotherapy followed by surgery in locally advanced thymic carcinoma.
abstract: Thymic carcinoma is a rare neoplasm with a poor prognosis. We report the clinical course of a patient who received complete surgical resection after effective induction treatment. A 72-year-old woman with advanced thymic carcinoma (squamous cell carcinoma, stage IVb) was considered as nonresectable due to invasion of neighboring organs and mediastinal lymph node metastasis. Two cycles of chemotherapy, consisting of paclitaxel (180 mg/m2) plus cisplatin (80 mg/m2), combined with thoracic radiotherapy (total 54 Gy) were performed concurrently and complete radical resection could then be performed. She is currently alive and ambulatory and has remained disease-free for two years. This multimodal treatment may be a good treatment option for locally advanced thymic carcinoma.
authors.affiliation: Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Okayama, Japan. mifukuda258@nifty.com
authors.forename: Minoru
authors.initials: M
authors.lastname: Fukuda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Obase
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Miyashita
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kobashi
authors.forename: Keiji
authors.initials: K
authors.lastname: Mohri
authors.forename: Shiro
authors.initials: S
authors.lastname: Ueno
authors.forename: Makio
authors.initials: M
authors.lastname: Hayama
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Shimizu
authors.forename: Hironori
authors.initials: H
authors.lastname: Nishimura
authors.forename: Masao
authors.initials: M
authors.lastname: Nakata
authors.forename: Mikio
authors.initials: M
authors.lastname: Oka
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use*; D013902:Radiography, Thoracic; D013945:Thymoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D013953:Thymus Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D017239:Paclitaxel; D002945:Cisplatin