Structure elucidation of compounds extracted from the Chinese medicinal plant Patrinia heterophylla.
For several hundred years, Patrinia heterophylla has been used in traditional Chinese medicine as a treatment for abscesses, hepatitis, tonsillitis, ulcers, etc. Recent research suggests that it may also have some anti-cancer activity. We have extracted five pure compounds from this plant; two known flavonols without bio-activity, one known isocoumarin glucoside that exhibits some cytotoxic activity toward HeLa cervical cancer cells, and two novel compounds that show considerable cytotoxic activity toward HeLa cells.
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Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA.
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Dalley
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Wood
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Owen
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D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D032405:Patrinia / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment
D001578:Benzopyrans; D004365:Drugs, Chinese Herbal; D044948:Flavonols; D005960:Glucosides