Does vitamin E prevent gentamicin-induced ototoxicity?
A randomized double-blind study was performed to check the protective efficacy of vitamin E against aminoglycoside ototoxicity. 52 patients scheduled for gentamicin therapy because of acute pulmonary infections have been tested. Volunteers were randomly assigned to receive additionally either vitamin E or placebo. The daily dosage of gentamicin amounted to 240 mg and that of vitamin E to 2800 mg. The treatment lasted 7 days. Hearing function was assessed before the start of medication and at the follow-up visit 6 to 8 weeks afterwards. Elevation of auditory thresholds occurred in similar number of patients in the vitamin-E and placebo groups and no statistically significant differences were found between. Vitamin E has been not confirmed thus to possess any protective action against gentamicin-induced ototoxicity.
Kharkheli
E
E
Centre of Audiology and Hearing Rehabilitation, Tbilisi, Georgia.
Kevanishvili
Z
Z
Maglakelidze
T
T
Davitashvili
O
O
Schacht
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D034381:Hearing Loss / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D018410:Pneumonia, Bacterial / Q000188:drug therapy; D014810:Vitamin E / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010919:Placebos; D014810:Vitamin E