Short and efficient diastereoselective synthesis of pyrrolidinone-containing dipeptide analogues.
The pyrrolidine-2,4-diones have been identified as a convenient starting point for the synthesis of peptide analogues. Herein we describe an optimized two-step reductive amination procedure, which provides a small library of pyrrolidinone-containing dipeptide analogues in high yield and excellent diastereoselectivity.
Hosseini
Masood
M
Department of Chemistry, Technical University of Denmark, Building 201, DK-2800 Kgs. Lyngby, Denmark.
Grau
Jakob S
JS
Sørensen
Kasper K
KK
Søtofte
Inger
I
Tanner
David
D
Murray
Anthony
A
Tønder
Janne E
JE
D000596:Amino Acids / Q000737:chemistry; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D011760:Pyrrolidinones / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D004151:Dipeptides; D011760:Pyrrolidinones