title: Reduction of stenosis due to intimal hyperplasia after stent supported angioplasty of peripheral arteries by local administration of paclitaxel in swine.
abstract: OBJECTIVE
  To assess if local intra-arterial administration of paclitaxel using drug-coated balloons or an admixture of paclitaxel to contrast medium inhibits stenosis after percutanous transluminal angioplasty (PTA) of peripheral arteries in a porcine overstretch model.
  
  
  METHODS
  Neointimal proliferation and stenosis were induced by overstretch and stenting of 40 peripheral arteries in 20 pigs. Paclitaxel was administered locally during PTA using coated balloons (n = 20) or dissolved in contrast medium (n = 10). Conventional balloons and contrast medium were used in a control group (n = 10). Reangiography with quantitative analysis was performed after 5 weeks.
  
  
  RESULTS
  On reangiography diameter stenosis and late lumen loss were significantly reduced by both methods of local drug delivery compared with control group; minimal luminal diameter was significantly larger in the treatment groups.
  
  
  CONCLUSIONS
  Local short-term administration of paclitaxel during PTA of peripheral arteries using balloons or contrast medium as drug carriers reduced stenosis due to intimal hyperplasia.
authors.affiliation: Department of Radiology and Nuclear Medicine, Campus Benjamin Franklin, Charité, Free University und Humboldt University Berlin, Berlin, Germany. thomas.albrecht@charite.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Albrecht
authors.forename: Ulrich
authors.initials: U
authors.lastname: Speck
authors.forename: Claudia
authors.initials: C
authors.lastname: Baier
authors.forename: Karl-Jürgen
authors.initials: KJ
authors.lastname: Wolf
authors.forename: Michael
authors.initials: M
authors.lastname: Böhm
authors.forename: Bruno
authors.initials: B
authors.lastname: Scheller
mesh_terms: D000792:Angiography / Q000379:methods*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D000818:Animals; D003251:Constriction, Pathologic / Q000517:prevention & control*; D007261:Infusions, Intra-Arterial; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage / Q000494:pharmacology*; D016491:Peripheral Vascular Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015607:Stents; D013552:Swine; D017539:Tunica Intima / Q000187:drug effects*
chemical_list: D017239:Paclitaxel