title: Chromosome instability and translocation t(11;18) in primary gastric marginal zone B-cell lymphoma of MALT-type.
abstract: The prognosis for patients with mucosa-associated lymphoid tissue (MALT) lymphomas is good; these tumours have usually an indolent course with overall survival rates that are greater than 80% at 5-year, but some rare cases with histological transformation in aggressive diffuse large cell lymphoma have also been diagnosed. Here, we present cytogenetic results on endoscopic bioptic material of 42 cases of primary gastric extranodal marginal zone B-cell lymphoma (EMZL) using fluorescence in situ hybridization (FISH) approach with API2, MALT1 and centromeric probes for chromosome 3 and 18, and their impact on the clinical outcome.
authors.affiliation: Anatomic Pathology Unit, University of Insubria, Ospedale di Circolo, Varese, Italy. mgtibiletti@hotmail.com
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Tibiletti
authors.forename: Katia
authors.initials: K
authors.lastname: Milani
authors.forename: Vittoria
authors.initials: V
authors.lastname: Martin
authors.forename: Emanuele
authors.initials: E
authors.lastname: Zucca
authors.forename: Teresio
authors.initials: T
authors.lastname: Motta
authors.forename: Sergio
authors.initials: S
authors.lastname: Cortelazzo
authors.forename: Graziella
authors.initials: G
authors.lastname: Pinotti
authors.forename: Luca
authors.initials: L
authors.lastname: Mazzucchelli
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Pruneri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
authors.forename: Renzo
authors.initials: R
authors.lastname: Barbazza
authors.forename: Carlo
authors.initials: C
authors.lastname: Capella
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertoni
mesh_terms: D001706:Biopsy; D002503:Centromere; D043171:Chromosomal Instability; D002880:Chromosomes, Human, Pair 11; D002887:Chromosomes, Human, Pair 18; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D008297:Male; D015335:Molecular Probes; D015514:Oncogene Proteins, Fusion / Q000032:analysis; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology; D015996:Survival Rate; D014178:Translocation, Genetic; D016896:Treatment Outcome
chemical_list: C415943:API2-MALT1 fusion protein, human; D015335:Molecular Probes; D015514:Oncogene Proteins, Fusion