title: [Dermatological side effects of epidermal growth factor receptor inhibitors].
abstract: Epidermal growth cell receptors (EGFR) play a key role in tumor proliferation. Their inhibitors (anti-EGFR) are promising treatments for various types of cancers. Papulopustular follicular eruptions are the most frequent dermatological side effect and occur in 45 to 85% of patients receiving this treatment. Paronychias appear after several weeks of treatment. They are painful and impair hand and foot function. A positive correlation seems to exist between the intensity of the papulo-follicular eruption, tumor regression and survival.
authors.affiliation: Service de dermatologie, Hôpital Edouard Herriot, Lyon (69).
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Doebelin
authors.forename: Arnaud
authors.initials: A
authors.lastname: Ly
authors.forename: Carole
authors.initials: C
authors.lastname: Allombert
authors.forename: Michel
authors.initials: M
authors.lastname: Faure
authors.forename: Alain
authors.initials: A
authors.lastname: Claudy
mesh_terms: D003875:Drug Eruptions / Q000209:etiology*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D006801:Humans
chemical_list: D066246:ErbB Receptors