Albumin-alginate-coated microspheres: resistance to steam sterilization and to lyophilization.
The paper describes the effect of different thermal treatments on the morphology and binding properties of particles prepared using a transacylation reaction between two biocompatible polymers, namely propylene glycol alginate and human serum albumin. Compared to control alginate gel microspheres, albumin-alginate covalent network offers a better resistance to the microspheres towards freezing, lyophilization and sterilization. The binding properties for methylene blue were not altered by the treatments. Moreover, stability in physiological environments opens interesting applications in biological and pharmaceutical fields.
Callewaert
Maïté
M
CNRS FRE 2715, Université de Reims-Champagne Ardenne, IFR 53, Faculté de Pharmacie, 51 rue Cognacq-Jay, 51100 Reims, France.
Laurent-Maquin
Dominique
D
Edwards-Lévy
Florence
F
D000215:Acylation; D000464:Alginates / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004355:Drug Stability; D005612:Freeze Drying; D005615:Freezing; D006361:Heating; D006801:Humans; D008751:Methylene Blue / Q000737:chemistry; D008863:Microspheres; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry*; D013227:Steam; D013242:Sterilization
D000464:Alginates; D004337:Drug Carriers; D012709:Serum Albumin; D013227:Steam; C038550:propylene glycol alginate ester; D008751:Methylene Blue