Glutaraldehyde cross-linked chitosan microspheres for controlled release of centchroman.
Glutaraldehyde cross-linked chitosan microspheres were prepared for controlled release of centchroman, a nonsteroidal contraceptive. The cross-linked microspheres with low-molecular-weight (LMW) chitosan (260 kg mol(-1)) have shown maximum degree of swelling (287 wt%) but were found to be poor in loading and release behavior for centchroman. The microspheres with medium-molecular-weight (MMW) chitosan (1134 kg mol(-1)) have shown 250 wt% degree of swelling and 37.5 wt% loading of centchroman, but microspheres with high-molecular-weight (HMW) chitosan (2224 kg mol(-1)) have shown a low degree of swelling (150 wt%) and centchroman loading (30 wt%). The microspheres with MMW chitosan have released 82 wt% of loaded centchroman in a controlled release manner within a period of 70 h in comparison to low- (260 kg mol(-1)) and high-MW (2224 kg mol(-1)) chitosan microspheres. The chitosan microspheres with 62 wt% degree of deacetylation (DDA) were more efficient in the controlled release of centchroman in comparison to chitosan microspheres with low (48 wt%) and high-DDA (75 wt%). The fractional release of centchroman (M(t)/M(infinity)) from chitosan microspheres was used to predict the mechanism of drug release and to determine the diffusion constant (D) of centchroman.
Gupta
K C
KC
Polymer Research Laboratory, Department of Chemistry, Indian Institute of Technology, Roorkee 247 667, India. kcgptfcy@iitr.ernet.in
Jabrail
Fawzi Habeeb
FH
D000107:Acetylation; D002486:Centchroman / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D048271:Chitosan / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers; D004339:Drug Compounding; D005976:Glutaral / Q000737:chemistry*; D008863:Microspheres; D008956:Models, Chemical; D008970:Molecular Weight; D013678:Technology, Pharmaceutical / Q000379:methods
D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D002486:Centchroman; D048271:Chitosan; D005976:Glutaral