title: Decreased anti-Müllerian hormone and altered ovarian follicular cohort in infertile patients with mild/minimal endometriosis.
abstract: OBJECTIVE
  To evaluate the ovarian reserve and follicular cohort of infertile patients with minimal/mild endometriosis.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Patients were divided into two groups: group I, minimal/mild endometriosis and group II, tubal obstruction. The following exclusion criteria were established: [1] patients with previous endocrine disorders; and [2] cases in which the cause for infertility was other than endometriosis (except for patients with tubal obstruction, in the control group).
  
  
  METHODS
  Serum FSH and anti-Müllerian hormone were measured on day 3. On the same day all patients were submitted to transvaginal ultrasound to evaluate the antral follicular count and the ovarian follicular cohort.
  
  
  METHODS
  Serum FSH, anti-Müllerian hormone, and the follicular cohort with the respective antral follicular count.
  
  
  RESULTS
  Serum FSH were not different between the groups. However, infertile patients with endometriosis have a decreased serum anti-Müllerian hormone (1.26 +/- 0.7 ng/mL) compared to the control group (2.02 +/- 0.72 ng/mL). The analysis of follicular cohort showed that the number of selectable follicles were similar, but the follicular diameter was different.
  
  
  CONCLUSIONS
  Minimal/mild endometriosis is associated with a decrease in the follicular ovarian reserve. In addition, the follicular cohort of these patients is more heterogeneous in comparison to the control group.
authors.affiliation: Department of Obstetrics and Gynecology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de Pós-graduação em Medicina: Ciências Médicas, Porto Alegre, Brazil.
authors.forename: Nadiane Albuquerque
authors.initials: NA
authors.lastname: Lemos
authors.affiliation: Department of Obstetrics and Gynecology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Elisangela
authors.initials: E
authors.lastname: Arbo
authors.affiliation: Unit of Biochemichemistry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Renata
authors.initials: R
authors.lastname: Scalco
authors.affiliation: Department of Obstetrics and Gynecology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Weiler
authors.affiliation: Department of Obstetrics and Gynecology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Virginia
authors.initials: V
authors.lastname: Rosa
authors.affiliation: Department of Obstetrics and Gynecology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de Pós-graduação em Medicina: Ciências Médicas, Porto Alegre, Brazil. Electronic address: sabino@via-rs.net.
authors.forename: João Sabino
authors.initials: JS
authors.lastname: Cunha-Filho
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015331:Cohort Studies; D004715:Endometriosis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D005184:Fallopian Tube Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D006080:Ovarian Follicle / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone