Control by reproduction-related hormones of resistin expression and plasma concentration.
Although not simultaneously, resistin expression in white adipose tissue (WAT) and resistin plasma concentration have been shown to increase in pregnant rats. To clarify the involvement of sex hormones in such increases, we administered for 3-5 days progesterone, estradiol, or human chorionic gonadotropin (hCG) to female rats in dioestrus II. Progesterone increased resistin expression retroperitoneal WAT but lacked effect in parametrial or subcutaneous depots. It also increased resistin plasma concentration. Estradiol decreased resistin expression in both parametrial and inguinal WAT but was without effect on retroperitoneal depots. It did not alter plasma resistin. Human hCG increased resistin expression in all the visceral depots examined - parametrial, inguinal and retroperitoneal - but did not change plasma resistin. These results show that hormonal influences in resistin expression are depot-dependent and can run separately from changes in its plasma concentration. Besides, the locally restricted effect of progesterone in resistin expression compared with that of hCG suggests it is not the only hormone enhancing resistin expression in early pregnancy. However, it could enhance resistin release in late pregnancy. Estradiol could be involved in the decrease of resistin expression in late pregnancy. Finally, since hCG acts through LH receptors, our results suggest that they are present in WAT and that they control resistin expression.
Caja
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S
Department of Animal Physiology II, Faculty of Biological Sciences, Complutense University, Madrid, Spain.
Puerta
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M
D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D006063:Chorionic Gonadotropin / Q000097:blood / Q000494:pharmacology; D004958:Estradiol / Q000097:blood / Q000494:pharmacology; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D012739:Gonadal Steroid Hormones / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D011374:Progesterone / Q000097:blood / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D052243:Resistin / Q000097:blood* / Q000235:genetics*
D006063:Chorionic Gonadotropin; D012739:Gonadal Steroid Hormones; D012333:RNA, Messenger; D052243:Resistin; D011374:Progesterone; D004958:Estradiol