title: An ultrasensitive young interferometer handheld sensor for rapid virus detection.
abstract: Future viral outbreaks are a major threat to societal and economic development throughout the world. A rapid, sensitive and easy-to-use test for viral infections is essential to prevent and control such viral pandemics. Furthermore, a compact, portable device is potentially very useful in remote or developing regions without easy access to sophisticated laboratory facilities. In this report we discuss the application of a Young interferometer sensor device for ultrasensitive and real-time detection of viruses. The essential innovation in this technique is the combination of an integrated optical interferometric sensor with antibody-antigen recognition approaches to yield very sensitive, rapid virus detection. The technology is amenable to miniaturization and mass production and, thus, has significant potential to be developed into a handheld, point-of-care device.
authors.affiliation: Biophysical Engineering, MESA, Faculty of Science and Technology, University of Twente, 7500 AE Enschede, The Netherlands. a.ymeti@utwente.nl
authors.forename: Aurel
authors.initials: A
authors.lastname: Ymeti
authors.forename: Vinod
authors.initials: V
authors.lastname: Subramaniam
authors.forename: Tom A M
authors.initials: TA
authors.lastname: Beumer
authors.forename: Johannes S
authors.initials: JS
authors.lastname: Kanger
mesh_terms: D004196:Disease Outbreaks; D004867:Equipment Design; D006801:Humans; D007368:Interferometry / Q000295:instrumentation* / Q000379:methods*; D036103:Nanotechnology; D012680:Sensitivity and Specificity; D014777:Virus Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D014780:Viruses / Q000302:isolation & purification*