title: Fabrication improvements for thermoset polyester (TPE) microfluidic devices.
abstract: Thermoset polyester (TPE) microfluidic devices were previously developed as an alternative to poly(dimethylsiloxane) (PDMS) devices, fabricated similarly by replica molding, yet offering stable surface properties and good chemical compatibility with some organics that are incompatible with PDMS. This paper describes a number of improvements in the fabrication of TPE chips. Specifically, we describe methods to form TPE devices with a thin bottom layer for use with high numerical aperture (NA) objectives for sensitive fluorescence detection and optical manipulation. We also describe plasma-bonding of TPE to glass to create hybrid TPE-glass devices. We further present a simple master-pretreatment method to replace our original technique that required the use of specialized equipment.
authors.affiliation: Department of Chemistry, University of Washington, Seattle, WA, USA.
authors.forename: Gina S
authors.initials: GS
authors.lastname: Fiorini
authors.forename: Moonbin
authors.initials: M
authors.lastname: Yim
authors.forename: Gavin D M
authors.initials: GD
authors.lastname: Jeffries
authors.forename: Perry G
authors.initials: PG
authors.lastname: Schiro
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Mutch
authors.forename: Robert M
authors.initials: RM
authors.lastname: Lorenz
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Chiu
mesh_terms: D002384:Catalysis; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004563:Electrochemistry; D004867:Equipment Design; D005898:Glass; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D044085:Microfluidics; D008856:Microscopy, Fluorescence; D008962:Models, Theoretical; D009995:Osmosis; D011091:Polyesters / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry; D012828:Silicones / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004129:Dimethylpolysiloxanes; D011091:Polyesters; D012821:Silanes; D012828:Silicones; C013830:baysilon