title: Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists.
abstract: A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPARgamma. The best PPARgamma agonist in this series was 9h, which showed an EC(50) value of 15 nM.
authors.affiliation: Bioorganic Science Division, Korea Research Institute of Chemical Technology, Yuseong-Gu, Daejeon 305-600, Republic of Korea. jhahn@krict.re.kr
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Ahn
authors.forename: Mi Sik
authors.initials: MS
authors.lastname: Shin
authors.forename: Sun Ho
authors.initials: SH
authors.lastname: Jung
authors.forename: Jin Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Hye Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Se Hoan
authors.initials: SH
authors.lastname: Kim
authors.forename: Seung Kyu
authors.initials: SK
authors.lastname: Kang
authors.forename: Kwang Rok
authors.initials: KR
authors.lastname: Kim
authors.forename: Sang Dal
authors.initials: SD
authors.lastname: Rhee
authors.forename: Sung Dae
authors.initials: SD
authors.lastname: Park
authors.forename: Jae Mok
authors.initials: JM
authors.lastname: Lee
authors.forename: Jeong Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Hyae Gyeong
authors.initials: HG
authors.lastname: Cheon
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
mesh_terms: D007192:Indenes / Q000737:chemistry* / Q000494:pharmacology*; D047495:PPAR gamma / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D007192:Indenes; D047495:PPAR gamma