Long-term use of nebulized human recombinant DNase1 in two siblings with primary ciliary dyskinesia.
Primary ciliary dyskinesia (PCD) is characterized by ultra-structural defects of the cilia. In this report, we describe the long-term use of nebulized dornase alfa in two siblings with PCD. This is the first report of long-term use of dornase alfa in PCD.
El-Abiad
Nisreen M
NM
Faculty of Medicine, Cairo University, Children's Hospital, Cairo, Egypt.
Clifton
Shelley
S
Nasr
Samya Z
SZ
D000293:Adolescent; D003850:Deoxyribonuclease I / Q000008:administration & dosage*; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D007619:Kartagener Syndrome / Q000188:drug therapy*; D008134:Long-Term Care / Q000379:methods; D008297:Male; D009330:Nebulizers and Vaporizers; D016896:Treatment Outcome
C085693:DNASE1 protein, human; D003850:Deoxyribonuclease I