Steady state of homozygosity and Gst for the island model.
We examine homozygosity and G(st) for a subdivided population governed by the finite island model. Assuming an infinite allele model and strong mutation we show that the steady state distributions of G(st) and homozygosity have asymptotic expansions in the mutation rate. We use this observation to derive asymptotic expansions for various moments of homozygosity and to derive rigorous formulas for the mean and variance of G(st). We show that G(st) approximately 1/(1+2Nm), similarly to the well known formula of Wright for the infinite island model, and that the variance of G(st) goes to zero as mutation increases.
Rottenstreich
Sivan
S
Department of Mathematics, Georgetown University, St. Mary's Building, Washington, DC 20057, USA. sr286@georgetown.edu
Miller
Judith R
JR
Hamilton
Matthew B
MB
D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D006720:Homozygote; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D014481:United States