[G[P] type profiles of group A human rotavirus and their distribution in Nizhni Novgorod and Dzerzhinsk in 1997-2005].
RT-PCR was used to determine G (VP7) and P (VP4) genotypes of group A rotavirus found in 2454 children with diarrhea in 1997-2005. Eight G[P] combinations, including G1-4 serotypes and P[4, 6, 8, 9] genotypes, were identified. The P[8] genotype was presented by the subtypes P[8]-1 and P[8]-2. In 1997-2005, the spectrum and distribution of G[P] types were as follows: G1P[8]-1 (10%), G1P[8]-2 (67%), G1P[6] (3%), G2P[4] (9%), G3P[8]-2 (5%), G3P[6] (1%), G3P[9] (1%), G4P[8]-2 (3%), G9 (0%), G?P[?] (1%). Five G[P] types of rotavirus were identified in the 2004-2005 season. The G2P[4] type was prevalent (37%), the GI P[8]-2 type was detected in 25% of cases; G3P[8]-2 in 22%; G4P[8]-2 in 12%; G3P in 2%), G[?]P[?] in 2%. The P[8]-1 subgemotype was not found. The spectrum of the G1P[8] types of rotavirus and their distribution should be taken into account while developing a vaccine prophylaxis program against rotavirus gastroenteritis in Russia.
Novikova
N A
NA
Fedorova
O F
OF
Epifanova
N V
NV
Chuprova
A B
AB
D000956:Antigens, Viral / Q000235:genetics; D036022:Capsid Proteins / Q000235:genetics; D005814:Genes, Viral / Q000235:genetics; D006801:Humans; D017720:Molecular Epidemiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012401:Rotavirus / Q000145:classification / Q000235:genetics*; D012400:Rotavirus Infections / Q000453:epidemiology*; D012426:Russia / Q000453:epidemiology; D013045:Species Specificity; D014505:Urban Population
D000956:Antigens, Viral; D036022:Capsid Proteins; C060339:VP4 protein, Rotavirus; C050779:VP7 protein, Rotavirus