title: Immune response to two different dosing schedules of the anthrax vaccine precipitated (AVP) vaccine.
abstract: A pilot study compared the immune response of regular (0, 3, 6, 32 weeks) and extended (0, 10, 13, 32 weeks) schedules of the UK anthrax vaccine (anthrax vaccine precipitated, AVP). Concentrations of antibodies to protective antigen (PA) were higher (p<0.05) among recipients of the extended (n=7) versus regular schedule (n=6) at week 32, and 2 weeks after the second and third vaccinations. Toxin neutralisation assay levels and anti-lethal factor antibodies followed patterns similar to anti-PA antibodies. Extending the interval between the first two AVP vaccinations may produce a stronger immune response, but persistence of this effect needs further study.
authors.affiliation: Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Wiltshire, United Kingdom. mjhepburn@mail.dstl.gov.uk
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Hepburn
authors.forename: E
authors.initials: E
authors.lastname: Hugh Dyson
authors.forename: Andrew J H
authors.initials: AJ
authors.lastname: Simpson
authors.forename: Karen E
authors.initials: KE
authors.lastname: Brenneman
authors.forename: Nicola
authors.initials: N
authors.lastname: Bailey
authors.forename: Lucy
authors.initials: L
authors.lastname: Wilkinson
authors.forename: Rebecca
authors.initials: R
authors.lastname: Hornby
authors.forename: Alfred J
authors.initials: AJ
authors.lastname: Mateczun
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Bell
authors.forename: Leslie W J
authors.initials: LW
authors.lastname: Baillie
mesh_terms: D000328:Adult; D000881:Anthrax / Q000276:immunology*; D022122:Anthrax Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D000907:Antibodies, Bacterial / Q000097:blood; D011232:Chemical Precipitation; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests
chemical_list: D022122:Anthrax Vaccines; D000907:Antibodies, Bacterial