Expression patterns of adhesion molecules P-selectin, von Willebrand factor and PECAM-1 in lungs: a comparative study in cases of burn shock and hemorrhagic shock.
For comparative examination of the pathological findings in burn shock and hemorrhagic shock, histological and immunohistochemical investigations of the lungs were performed. Histological specimens of 30 cases each were examined by means of immunohistological staining with P-selectin, von Willebrand factor (vWF) and PECAM-1. The results showed statistically significant differences between the two groups. There was strong staining for P-selectin (especially in the lumina of the blood vessels) and vWF (especially in the endothelium of medium-sized blood vessels) in the specimens of burn shock fatalities. In cases of rapid death after exposure to fire the strong expression of adhesion molecules, which are mainly responsible for the initial inflammatory reaction of leucocytes and platelets in burn shock, suggests prompt activation of inflammatory cells in the lung tissue. In cases of hemorrhagic shock, this reaction was much less distinct in the early stages. The same is true of the expression of PECAM-1, which was lower in lungs from burn shock fatalities than in those from hemorrhagic shock fatalities. The low expression of PECAM-1 in burn shock is a clue to the migration/diapedesis of leucocytes into the areas of burn damage. In total, the results of the investigation indicate different pathophysiological processes even in the very early stages of burn shock and hemorrhagic shock.
Weis
Andreas
A
Institute of Forensic Medicine, Albert - Ludwig University Freiburg, Albertstrasse 9, 79104 Freiburg, Germany.
Bohnert
Michael
M
D001808:Blood Vessels / Q000378:metabolism / Q000473:pathology; D002056:Burns / Q000378:metabolism* / Q000473:pathology; D004727:Endothelium / Q000378:metabolism / Q000473:pathology; D005260:Female; D049429:Forensic Pathology; D006470:Hemorrhage / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D019007:P-Selectin / Q000378:metabolism*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism*; D011654:Pulmonary Edema / Q000473:pathology; D012769:Shock / Q000378:metabolism* / Q000473:pathology; D012771:Shock, Hemorrhagic / Q000378:metabolism* / Q000473:pathology; D013927:Thrombosis / Q000473:pathology; D014841:von Willebrand Factor / Q000378:metabolism*
D019007:P-Selectin; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014841:von Willebrand Factor