Serum levels of OPG, RANKL and RANKL/OPG ratio in newly-diagnosed patients with multiple myeloma. Clinical correlations.
Serum levels of OPG and RANKL and their clinical correlations were analyzed in 66 newly-diagnosed patients with multiple myeloma (MM). RANKL and RANKL /OPG ratio were significantly increased in advanced clinical stages and high grade myeloma bone disease (MBD), while OPG showed a tendency to decrease. Renal failure modified the expression of OPG. RANKL and RANKL/OPG ratios are informative markers for myeloma tumor burden and MBD.
Goranova-Marinova
Veselina
V
Clinic of Hematology, University Hospital Sv. Georgi-Plovdiv, Plovdiv, Bulgaria. vesselina_goranova@yahoo.com
Goranov
Stefan
S
Pavlov
Pavel
P
Tzvetkova
Todorka
T
D015415:Biomarkers / Q000097:blood; D001859:Bone Neoplasms / Q000175:diagnosis; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis*; D053244:Osteoprotegerin / Q000097:blood*; D053245:RANK Ligand / Q000097:blood*; D051437:Renal Insufficiency / Q000175:diagnosis; D047368:Tumor Burden
D015415:Biomarkers; D053244:Osteoprotegerin; D053245:RANK Ligand