title: Lepidepyrone, a new gamma-pyrone derivative, from Neolentinus lepideus, inhibits hyaluronidase.
abstract: In the course of screening for hyaluronidase (HAase) inhibitory agents, a new gamma-pyrone derivative, lepidepyrone, C(8)H(10)O(5), was isolated from the cultured mycelium of the mushroom Neolentinus lepideus TMC-1102 as a major HAase inhibitory compound (IC(50) 3.3 mM). The structure of lepidepyrone was established on the basis of spectroscopic investigation.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara, Tokyo, Japan. kawai@hoshi.ac.jp
authors.forename: Tomoo
authors.initials: T
authors.lastname: Hosoe
authors.forename: Hideo
authors.initials: H
authors.lastname: Sakai
authors.forename: Makoto
authors.initials: M
authors.lastname: Ichikawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Itabashi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ishizaki
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Kawai
mesh_terms: D001487:Basidiomycota / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020128:Inhibitory Concentration 50; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004791:Enzyme Inhibitors; D011753:Pyrones; D006821:Hyaluronoglucosaminidase