title: Gamma-glutamyltransferase, redox regulation and cancer drug resistance.
abstract: Gamma-glutamyltransferase, a key enzyme of GSH metabolism, can modulate crucial redox-sensitive functions, such as antioxidant/antitoxic defences and cellular proliferative/apoptotic balance, with potential implications in tumour progression and drug resistance. Recent studies have elucidated the mechanisms of GGT involvement in various pathological processes suggesting its potential role as therapeutic target and diagnostic/prognostic marker.
authors.affiliation: Dipartimento di Patologia Sperimentale, Università di Pisa, Scuola MedicaVia Roma 55, 56126 Pisa, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Pompella
authors.forename: Alessandro
authors.initials: A
authors.lastname: Corti
authors.forename: Aldo
authors.initials: A
authors.lastname: Paolicchi
authors.forename: Chiara
authors.initials: C
authors.lastname: Giommarelli
authors.forename: Franco
authors.initials: F
authors.lastname: Zunino
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016503:Drug Delivery Systems; D019008:Drug Resistance, Neoplasm; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D010084:Oxidation-Reduction; D011379:Prognosis; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D005723:gamma-Glutamyltransferase; D005978:Glutathione