Squamous cell carcinoma of the tongue in a 13-year-old girl with Fanconi anemia.
We report the case of a 13-year-old girl with squamous cell carcinoma (SCC) of the tongue. Fanconi anemia with a yet unknown complementation group had been diagnosed at the age of 5 years. Organ involvement included intestinal atresia, renal dysfunction due to crossed renal atopia, and tubular acidosis type II. Because of repeated bleeding complications frequent transfusions, and severe infections, bone marrow transplantation (BMT) from a matched unrelated donor was done at the age of 11 years. The girl did not suffer from graft-versus-host disease and had complete hematologic reconstitution after transplantation. Two years after BMT a SCC of the tongue developed without nodal or systemic metastasis. The tumor could be completely resected and no functional disturbances remained. No further treatment was given and the patient is in complete remission 6 months after diagnosis. This is one of the youngest children reported with SCC of the tongue after BMT for Fanconi anemia so far.
Reinhard
Harald
H
Pediatric Oncology and Hematology, University Hospital Homburg, Homburg, Saarland, Germany. harald.reinhard@uniklinik-saarland.de
Peters
Isabelle
I
Gottschling
Sven
S
Ebell
Wolfram
W
Graf
Norbert
N
D000293:Adolescent; D016026:Bone Marrow Transplantation; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D005199:Fanconi Anemia / Q000150:complications* / Q000628:therapy; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D014062:Tongue Neoplasms / Q000209:etiology*