Extranodal type T/NK-cell lymphoma with an atypical clinical presentation.
Peripheral-type natural killer (NK)- or T-cell lymphomas are rare disorders characterized with clonal proliferation of mature lymphocytes. They have been linked to chronic and active Epstein-Barr virus infection (CAEBV), which itself is not defined as a malignant hematological disorder. The authors present a patient with T/NK-cell lymphoma involving skin, kidneys, spleen, pancreas, and meninges. She was remarkable for having the mosaic feature of more than one type of extranodal T/NK-cell lymphoma. She also had mixed findings of CAEBV that might have been attributed both to hypersensitivity to mosquito bites and to hemophagocytic lymphohistiocytosis.
Aydin
G Burça
GB
Department of Pediatric Oncology, Hacettepe University, Institute of Oncology, Ankara, Turkey. burcaaydin@yahoo.com
Akyuz
Canan
C
Talim
Beril
B
Evans
Sibel Ersoy
SE
Sahin
Sedef
S
Sari
Neriman
N
Tabanlioglu
Duru
D
Ozen
Seza
S
Cağlar
Melda
M
Büyükpamukçu
Münevver
M
D000293:Adolescent; D002999:Clone Cells / Q000473:pathology; D020031:Epstein-Barr Virus Infections; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D014018:Tissue Distribution