title: Relationship among adiponectin, adiponectin gene expression and fatty acids composition in morbidly obese patients.
abstract: BACKGROUND
  The aim of this study was to examine the relationship between adiponectin plasma circulating levels and its gene expression in two abdominal fat depots (subcutaneous and visceral) with the fatty acid composition of plasma and adipose tissue in morbidly obese subjects.
  
  
  METHODS
  20 patients (10 women and 10 men) were selected. All were morbidly obese (BMI > or =40 kg/m2) and admitted for gastric surgery. Plasma samples and adipose tissue from both subcutaneous and visceral regions were obtained. Plasma adiponectin and adipose adiponectin expression were analyzed.
  
  
  RESULTS
  Adiponectin mRNA expression in the subcutaneous tissue was significantly higher (P=0.048) than in visceral tissue. Circulating adiponectin values, were positively associated with the proportion of n-3 polyunsaturated fatty acids in plasma (r=0.62, P=0.002). The visceral depot showed greater statistical associations between adiponectin gene expression and fatty acids profile, being saturated fatty acids associated with a decrease (r=-0.68, P=0.015), whereas monounsaturated were related to an increase in this adipose region (r=0.67, P=0.017).
  
  
  CONCLUSIONS
  We demonstrated significant associations between adipose tissue adiponectin gene expression and fatty acid composition. These associations were more evident in relation to the visceral depot, an adipose tissue region highly implicated in the metabolic syndrome.
authors.affiliation: Department of Physiology, University of Murcia, Murcia, Spain.
authors.forename: Juan Jose
authors.initials: JJ
authors.lastname: Hernandez-Morante
authors.forename: Fermin Ignacio
authors.initials: FI
authors.lastname: Milagro
authors.forename: Elvira
authors.initials: E
authors.lastname: Larque
authors.forename: Juan
authors.initials: J
authors.lastname: Lujan
authors.forename: Jose Alfredo
authors.initials: JA
authors.lastname: Martinez
authors.forename: Salvador
authors.initials: S
authors.lastname: Zamora
authors.forename: Marta
authors.initials: M
authors.lastname: Garaulet
mesh_terms: D052242:Adiponectin / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D050507:Subcutaneous Fat, Abdominal / Q000378:metabolism*
chemical_list: D052242:Adiponectin; D005227:Fatty Acids; D012333:RNA, Messenger