[Comparative study on in vitro drug-release between Tuizhang ophthalmic gel and Tuizhang oculentum].
OBJECTIVE
To prepare tuizhang gel to cure cataract, the characteristics of Tuizhang gel on the drug-releasing in vitro were evaluated by compared with Tuizhang oculentum.


METHODS
The emodin and chrysophanol in the releasing mediator were determined by HPLC, and the drug releasing characteristics of Tuizhang gel and Tuizhang oculentum were studied by bag filter method.


RESULTS
The emodin and chrysophanol in Tuizhang gel released (98.3, 1.1)%, (95.8, 1.8)% within 24 hours, respectively, while those in tuizhang oculentum released (10.62, 0.7)%, (10.46, 0.4)%, respectively. The emodin and chrysophanol in Tuizhang gel released more quickly and completely than in Tuizhang oculentum, so Tuizhang gel has enhanced the bioavailability.


CONCLUSIONS
The Tuizhang gel is characterized by slow-release to some degree, and it shows a promising future on ophthalmic drug delivery.
Wang
Guo-hua
GH
Institute of Chinese Materia Medica, China Academy of CMS, Beijing 100700, China.
Nie
Qi-xia
QX
Li
Hui
H
Zang
Chen
C
Zhang
Bao-xian
BX
Zhao
Xiao-mei
XM
D000180:Acrylic Resins / Q000737:chemistry; D000880:Anthraquinones / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D004642:Emodin / Q000737:chemistry / Q000493:pharmacokinetics; D005782:Gels; D009824:Ointments; D010946:Plants, Medicinal / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
D000180:Acrylic Resins; D000880:Anthraquinones; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D005782:Gels; D009824:Ointments; C479038:carbomer; D004642:Emodin; C027113:chrysophanic acid