title: The response of subcutaneous connective tissue to a new endodontic filling material.
abstract: The purpose of this histopathologic study was to assess and compare the subcutaneous connective tissue reaction to a new root canal filling material, Resilon and gutta-percha. The test materials were directly inserted subcutaneously into the dorsal connective tissue of Wistar albino rats. Histopathological examinations were done at 7, 15, 30, and 60 days after the implantation procedure. The presence of inflammation, predominant cell types, and the thickness of fibrous connective tissue adjacent to each inserted sample were recorded. There were no differences in tissue reaction between Resilon cone material and gutta-percha cone groups for first three observation periods (p > 0.05). However, there were highly significant differences among observation periods within both groups (7, 15, 30, and 60 days) (p < 0.01). The tissues showed high tolerance to Resilon and gutta-percha at the 60th day. Resilon may serve as an alternative to gutta-percha in terms of biocompatibility.
authors.affiliation: Operative Dentistry and Endodontics Department, Faculty of Dentistry, Ondokuz Mayis University, Samsun, Turkey. bodrumlu@omu.edu.tr
authors.forename: Emre
authors.initials: E
authors.lastname: Bodrumlu
authors.forename: Mehtap
authors.initials: M
authors.lastname: Muglali
authors.forename: Mahmut
authors.initials: M
authors.lastname: Sumer
authors.forename: Tolga
authors.initials: T
authors.lastname: Guvenc
mesh_terms: D000818:Animals; D004708:Endodontics; D006171:Gutta-Percha; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials; D012389:Root Canal Obturation; D040521:Subcutaneous Tissue / Q000473:pathology*; D013997:Time Factors
chemical_list: D012387:Root Canal Filling Materials; C486892:resilon sealer; D006171:Gutta-Percha