title: In vitro induction of apoptosis in tumor cells by inactivated NDV and IAV.
abstract: We examined how Newcastle disease virus (NDV) and influenza A virus (IAV) inactivated by 5% formaldehyde, used either alone or in combination, can induce apoptosis in both HeLa and SP2/0 cells. Inactive NDV and IAV demonstrated enhanced rates of lysis in apoptotic tumor cells and greater antitumor effects when combined. Our study supports the argument that viral replication does not cause virally induced apoptosis.
authors.affiliation: Laboratory of Biochemistry and Molecular Biology, College of Biological Sciences, China, Agricultural University, Beijing, China.
authors.forename: ShuYan
authors.initials: S
authors.lastname: Yang
authors.forename: WeiQuan
authors.initials: W
authors.lastname: Liu
authors.forename: HuanXian
authors.initials: H
authors.lastname: Cui
authors.forename: ShaoGuang
authors.initials: S
authors.lastname: Sun
authors.forename: JiGui
authors.initials: J
authors.lastname: Wang
mesh_terms: D017209:Apoptosis; D045744:Cell Line, Tumor; D048430:Cell Shape; D005434:Flow Cytometry; D006801:Humans; D009980:Influenza A virus; D008854:Microscopy, Electron; D009369:Neoplasms / Q000473:pathology*; D009522:Newcastle disease virus; D038301:Virus Inactivation