Damage to erythrocyte membranes as the mechanism for acrylate toxicity.
Acute poisoning with acrylates (acrylamide and acrylonitrile) was associated with damage to erythrocyte membranes: early stages of acrylamide poisoning were characterized by impairment of the acid resistance of erythrocytes, while later terms of acrylate intoxication were accompanied by condensation of erythrocyte membranes. Activation of lipid peroxidation in blood plasma and erythrocytes was observed during the early stage of intoxication, while at later terms LPO intensity in erythrocytes decreased.
Tarskikh
M M
MM
Department of Hygiene, Krasnoyarsk Medical Academy, Russian Federal Agency for Health Protection and Social Development, Russia.
D000179:Acrylates / Q000633:toxicity*; D000181:Acrylonitrile / Q000633:toxicity*; D000818:Animals; D021461:Animals, Outbred Strains; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D006851:Hydrochloric Acid / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D013997:Time Factors
D000179:Acrylates; D008315:Malondialdehyde; C036658:acrylic acid; D000181:Acrylonitrile; D006851:Hydrochloric Acid