title: [Urinary tract infection and neurogenic bladder].
abstract: One of the main complications of spinal cord injury is neurogenic bladder when the bladder fails to empty spontaneously. Urinary tract infection is the leading cause of morbidity and the second cause of mortality in these subjects. Patient education and personalized medical follow-up must ensure adapted management depending on the risk factors and the voiding mode. The risk of urinary tract infection can be decreased by perfect neurological control of detrusor activity combined with a method of drainage: intermittent self-catheterization. Despite these measures, many patients experience recurrent symptomatic urinary tract infections. Repeated antibiotic therapy increases the risk of selection of multiresistant bacteria without reducing either the incidence or the severity of symptomatic urinary tract infections. Asymptomatic bacteriuria is very frequent in patients treated by intermittent catheterization and does not justify antibiotic therapy, as antiseptics and urinary alkalinizers or acidifiers have been shown to be effective. "Antibiocycle" strategies could have a beneficial role by significantly decreasing the number of infections and hospitalizations with no major ecological risks, by using molecules that are well tolerated orally with a low selection pressure. All febrile urinary tract infections require rapid investigation and an urgent urological and infectious diseases opinion (abscess, severe sepsis, resistance). The SPILF-AFU 2002 consensus conference provided answers to major questions concerning the definition, treatment and prevention of nosocomial urinary tract infection, especially in a context of neurogenic bladder.
authors.affiliation: Service d'infectiologie, Hôpital Raymond Poincare, Garches, France. salomon.jerom@rpc.aphp.fr
authors.forename: J
authors.initials: J
authors.lastname: Salomon
authors.forename: A
authors.initials: A
authors.lastname: Gory
authors.forename: L
authors.initials: L
authors.lastname: Bernard
authors.forename: A
authors.initials: A
authors.lastname: Ruffion
authors.forename: P
authors.initials: P
authors.lastname: Denys
authors.forename: E
authors.initials: E
authors.lastname: Chartier-Kastler
mesh_terms: D003428:Cross Infection / Q000175:diagnosis / Q000209:etiology; D003937:Diagnosis, Differential; D006801:Humans; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology