title: Chiral separation of sympathomimetics and beta-blockers by ligand-exchange CE using Cu(II) complexes of L-tartaric acid and L-threonine as chiral selectors.
abstract: This paper deals with the use of Cu(II) complexes of L-tartaric acid or L-threonine as selectors for the chiral separation of drugs containing amino alcohol structure by ligand-exchange CE. Using Cu(II) ions as a complexing agent, a series of sympathomimetics and beta-blockers were resolved. It was found that the resolution strongly depends on selector concentration and pH. The optimum pH for complexation was 12.
authors.affiliation: Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, Karl-Franzens-University, Graz, Austria.
authors.forename: Heike
authors.initials: H
authors.lastname: Hödl
authors.forename: Axel
authors.initials: A
authors.lastname: Krainer
authors.forename: Katja
authors.initials: K
authors.lastname: Holzmüller
authors.forename: Julia
authors.initials: J
authors.lastname: Koidl
authors.forename: Martin G
authors.initials: MG
authors.lastname: Schmid
authors.forename: Gerald
authors.initials: G
authors.lastname: Gübitz
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000302:isolation & purification*; D000605:Amino Alcohols / Q000302:isolation & purification*; D003300:Copper; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D013237:Stereoisomerism; D013566:Sympathomimetics / Q000302:isolation & purification*; D013644:Tartrates; D013912:Threonine
chemical_list: D000319:Adrenergic beta-Antagonists; D000605:Amino Alcohols; D008024:Ligands; D013566:Sympathomimetics; D013644:Tartrates; D013912:Threonine; D003300:Copper; C029768:tartaric acid