title: Olfactory esthesioneuroblastoma treated with orthovoltage radiotherapy in a dog.
abstract: A 13-year-old neutered female mongrel dog presented with a 1-year history of stertorous respiration. On computed tomography examination, a mass was demonstrated in the nasal cavity. Open biopsy of the mass was performed and a diagnosis of olfactory esthesioneuroblastoma was made on histological examination. The dog was treated with orthovoltage x-ray radiation (total dose; 53 Gy given in 14 fractions over an 8 week period). Computed tomography after the twelfth irradiation revealed that tumour size had decreased. Although clinical signs were absent in the 4 months after irradiation, re-growth of the tumour was detected by radiographic evaluation and histological examination. The dog was again treated with orthovoltage x-ray radiation (total dose; 30 Gy given in three fractions over a 4-week period), however, tumour regrowth was again detected 3 months later. Clinical treatment of this tumour type has not been previously reported.
authors.affiliation: Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Japan. uehiro@cc.gifu-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Ueno
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Yamada
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology / Q000532:radiotherapy*; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D018304:Esthesioneuroblastoma, Olfactory / Q000473:pathology / Q000532:radiotherapy / Q000662:veterinary*; D005260:Female; D009364:Neoplasm Recurrence, Local; D011879:Radiotherapy Dosage; D014965:X-Rays