Activity of antioxidant enzymes in the skin during surgical wounds.
Full-thickness skin wounds (460 mm(2)) in rats were associated with increased blood chemiluminescence and neutrophil infiltration of the wound tissue and surrounding skin (recorded by myeloperoxidase activity). Activities of glutathione peroxidase and glutathione S-transferase in the skin and wound tissue increased on days 4 and 8. A correlation was revealed between activities of these enzymes and myeloperoxidase activity. Activities of myeloperoxidase and catalase increased in patient's skin excised during plastic surgeries of more than 2.5 h duration.
Mikhal'chik
E V
EV
Russian State Medical University, Moscow, Russia.
Anurov
M V
MV
Titkova
S M
SM
Miroshnikova
E A
EA
Lukasheva
E V
EV
Deeva
I B
IB
Ibragimova
G A
GA
Korkina
L G
LG
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D062109:Dermatologic Surgical Procedures; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors; D014947:Wounds and Injuries / Q000378:metabolism*
D000975:Antioxidants; D002374:Catalase; D009195:Peroxidase; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase