Accumulation of bisphenol A in hemodialysis patients.
Bisphenol A [BPA, 2,2-bis(4-hydoxyphenyl)propane], an industrial chemical used in the production of polycarbonate, epoxide resin, and polyarylate, is considered to be an endocrine-disrupting chemical. BPA may be present in some hollow-fiber dialyzers used in hemodialysis. In this study, we tested the amounts of BPA eluted from various hollow fibers. Furthermore, we measured the BPA concentration in the sera of 22 renal disease predialysis patients, as well as 15 patients who were receiving hemodialysis, to see if there is BPA accumulation in these patients. The elution test of BPA showed that a much larger amount of BPA was eluted from polysulfone (PS), and polyester-polymeralloy hollow fibers. Among renal disease patients who had not undergone hemodialysis, the serum BPA concentration increased as the renal function deteriorated, showing a significant negative association. In a crossover test between PS and cellulose (Ce) dialyzers, the predialysis serum BPA concentration of PS dialyzer users decreased after changing to a Ce dialyzer, and the serum BPA increased again after switching back to PS dialyzers. In patients who were using PS dialyzers, the BPA level significantly increased after a dialysis session. However, in the Ce dialyzer users, the BPA level decreased. Since accumulation of BPA could affect the endocrine or metabolic system of the human body, it is important to perform further investigations on dialysis patients.
Murakami
Kazutaka
K
Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Japan. nephrokm@fj9.so-net.ne.jp
Ohashi
Atsushi
A
Hori
Hideo
H
Hibiya
Makoto
M
Shoji
Yumiko
Y
Kunisaki
Miyuki
M
Akita
Miho
M
Yagi
Akira
A
Sugiyama
Kazuhiro
K
Shimozato
Sachiko
S
Ito
Kazuhiro
K
Takahashi
Hiroki
H
Takahashi
Kazuo
K
Yamamoto
Kouichirou
K
Kasugai
Masami
M
Kawamura
Nahoko
N
Nakai
Shigeru
S
Hasegawa
Midori
M
Tomita
Makoto
M
Nabeshima
Kunihiro
K
Hiki
Yoshiyuki
Y
Sugiyama
Satoshi
S
D000368:Aged; D001559:Benzhydryl Compounds; D002482:Cellulose / Q000031:analogs & derivatives; D018592:Cross-Over Studies; D052244:Endocrine Disruptors / Q000032:analysis*; D004866:Equipment Contamination; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010636:Phenols / Q000032:analysis*; D011091:Polyesters; D011108:Polymers; D019904:Polymethyl Methacrylate; D006435:Renal Dialysis / Q000009:adverse effects / Q000295:instrumentation*; D012680:Sensitivity and Specificity; D013450:Sulfones; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D002482:Cellulose; D052244:Endocrine Disruptors; D008567:Membranes, Artificial; D010636:Phenols; D011091:Polyesters; D011108:Polymers; D019904:Polymethyl Methacrylate; D013450:Sulfones; C017662:polysulfone P 1700; C024671:cellulose triacetate; C006780:bisphenol A; D000098826:Bisphenol A Compounds