Extract of Salacia oblonga lowers acute glycemia in patients with type 2 diabetes.
BACKGROUND
Two previous studies tested the efficacy of Salacia oblonga extract in healthy adults.


OBJECTIVE
This study evaluated the effect of an herbal extract of Salacia oblonga on postprandial glycemia and insulinemia in patients with type 2 diabetes after ingestion of a high-carbohydrate meal.


METHODS
Sixty-six patients with diabetes were studied in this randomized, double-blinded crossover study. In a fasted state, subjects consumed 1 of the following 3 meals: a standard liquid control meal, a control meal + 240 mg Salacia oblonga extract, and a control meal + 480 mg Salacia oblonga extract. Serum glucose and insulin samples were measured at baseline and at postprandial intervals up to 180 min.


RESULTS
Both doses of the Salacia extract significantly lowered the postprandial positive area under the glucose curve (14% for the 240 mg extract and 22% for the 480 mg extract) and the adjusted peak glucose response (19% for the lower dose and 27% for the higher dose of extract) to the control meal. In addition, both doses of the herbal extract significantly decreased the postprandial insulin response, lowering both the positive area under the insulin curve and the adjusted peak insulin response (14% and 9%, respectively, for the 240 mg extract; 19% and 12%, respectively, for the 480 mg extract) in comparison with the control meal.


CONCLUSIONS
The extract of Salacia oblonga lowers acute glycemia and insulinemia in persons with type 2 diabetes after a high-carbohydrate meal. The results from this study suggest that Salacia may be beneficial to this population for postprandial glucose control.
Williams
Jennifer A
JA
Ross Products Division of Abbott Laboratories, Columbus, OH 43215, USA. jennifer.williams@abbott.com
Choe
Yong S
YS
Noss
Michael J
MJ
Baumgartner
Carl J
CJ
Mustad
Vikkie A
VA
D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy*; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000494:pharmacology*; D019518:Postprandial Period; D049918:Salacia / Q000737:chemistry*
D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts