title: [Comparative study on in vitro drug-release between Tuizhang ophthalmic gel and Tuizhang oculentum].
abstract: OBJECTIVE
  To prepare tuizhang gel to cure cataract, the characteristics of Tuizhang gel on the drug-releasing in vitro were evaluated by compared with Tuizhang oculentum.
  
  
  METHODS
  The emodin and chrysophanol in the releasing mediator were determined by HPLC, and the drug releasing characteristics of Tuizhang gel and Tuizhang oculentum were studied by bag filter method.
  
  
  RESULTS
  The emodin and chrysophanol in Tuizhang gel released (98.3, 1.1)%, (95.8, 1.8)% within 24 hours, respectively, while those in tuizhang oculentum released (10.62, 0.7)%, (10.46, 0.4)%, respectively. The emodin and chrysophanol in Tuizhang gel released more quickly and completely than in Tuizhang oculentum, so Tuizhang gel has enhanced the bioavailability.
  
  
  CONCLUSIONS
  The Tuizhang gel is characterized by slow-release to some degree, and it shows a promising future on ophthalmic drug delivery.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of CMS, Beijing 100700, China.
authors.forename: Guo-hua
authors.initials: GH
authors.lastname: Wang
authors.forename: Qi-xia
authors.initials: QX
authors.lastname: Nie
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Chen
authors.initials: C
authors.lastname: Zang
authors.forename: Bao-xian
authors.initials: BX
authors.lastname: Zhang
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Zhao
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000880:Anthraquinones / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D004642:Emodin / Q000737:chemistry / Q000493:pharmacokinetics; D005782:Gels; D009824:Ointments; D010946:Plants, Medicinal / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000180:Acrylic Resins; D000880:Anthraquinones; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D005782:Gels; D009824:Ointments; C479038:carbomer; D004642:Emodin; C027113:chrysophanic acid