Late dietary intervention limits benefits of soy protein or flax oil in experimental polycystic kidney disease.
OBJECTIVE
Dietary soy protein and flax oil retard kidney disease progression when initiated in the early stages of disease in several experimental models, including the Han:SPRD-cy rat. However, individuals with kidney disease often do not become aware of their condition until injury to the kidney is extensive. The objective of this study was to determine whether initiating these interventions in established disease would alter further progression of renal injury.


METHODS
Two-month-old adult male Han:SPRD-cy rats were given either a flax oil diet (7% flax oil), a soy protein diet (20% soy protein) or a control diet (7% corn oil, 20% casein) for 4 months. Renal disease progression was assessed by examining morphological, immunohistochemical and biochemical parameters.


RESULTS
Compared to controls, there was 21-24% less staining of proliferating cells, 21-24% less oxidative damage and 13-15% less renal inflammation in kidneys from rats given dietary soy protein and flax oil. Renal cystic growth and fibrosis and serum creatinine levels were not altered by these dietary treatments.


CONCLUSIONS
Late intervention with dietary soy protein and flax oil reduces some disease-associated pathologies in established renal disease in Han:SPRD-cy rats. The potential benefits of the antioxidant and anti-inflammatory effects on ultimate renal disease outcome in the long term remains to be determined.
Sankaran
Deepa
D
Departments of Human Nutritional Sciences, University of Manitoba, Winnipeg, Man., Canada.
Bankovic-Calic
Neda
N
Cahill
Leah
L
Yu-Chen Peng
Claudia
C
Ogborn
Malcolm R
MR
Aukema
Harold M
HM
D000284:Administration, Oral; D000818:Animals; D004334:Drug Administration Schedule; D007668:Kidney / Q000187:drug effects* / Q000473:pathology*; D008043:Linseed Oil / Q000008:administration & dosage*; D007690:Polycystic Kidney Diseases / Q000178:diet therapy* / Q000473:pathology*; D051381:Rats; D030262:Soybean Proteins / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome
D030262:Soybean Proteins; D008043:Linseed Oil