title: Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.
abstract: Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.
authors.affiliation: Institute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany.
authors.forename: Elmi N
authors.initials: EN
authors.lastname: Zainuddin
authors.forename: Renate
authors.initials: R
authors.lastname: Mentel
authors.forename: Victor
authors.initials: V
authors.lastname: Wray
authors.forename: Rolf
authors.initials: R
authors.lastname: Jansen
authors.forename: Manfred
authors.initials: M
authors.lastname: Nimtz
authors.forename: Michael
authors.initials: M
authors.lastname: Lalk
authors.forename: Sabine
authors.initials: S
authors.lastname: Mundt
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005858:Germany; D009980:Influenza A virus / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D046931:Microcystis / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000998:Antiviral Agents; D047630:Depsipeptides; C522137:ichthyopeptin A; C522138:ichthyopeptin B