Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women.
Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. We evaluated the associations between two CYP1A1 polymorphisms [MspI (rs4646903); Ile462Val (rs1048943)] and breast cancer in a multicenter case-control study of 513 breast cancer cases and 447 controls in Korea. Women carrying the T allele of the CYP1A1 MspI polymorphism were found to have a 1.72-fold (95% CI 1.11-2.68) greater risk of developing breast cancer. No association was found between any CYP1A1 Ile462Val polymorphism and breast cancer. Haplotype analysis of the two loci showed that the CA haplotype was associated with the lowest risk of breast cancer, and CA/CA diplotypes were associated with a lower risk of breast cancer [OR=0.28 (0.13-0.61)] than others/others diplotypes. Moreover, this reduced risk was more pronounced among women with a lower body mass index (BMI) [OR=0.18 (0.06-0.58)] or with a shorter lifetime exposure to estrogen [OR=0.23 (0.07-0.81)]. The results obtained suggest that the CYP1A1 MspI polymorphisms could affect susceptibility to breast cancer.
Shin
Aesun
A
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea.
Kang
Daehee
D
Choi
Ji-Yeob
JY
Lee
Kyoung-Mu
KM
Park
Sue Kyung
SK
Noh
Dong-Young
DY
Ahn
Sei-Hyun
SH
Yoo
Keun-Young
KY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008875:Middle Aged; D011110:Polymorphism, Genetic
D019363:Cytochrome P-450 CYP1A1