Brain volumes in Guam dementia vs Parkinson dementia complex vs aging Chamorro adults.
We sought to determine if Chamorro individuals with a family history of Guam dementia (GD) or Parkinson dementia complex (PDC) exhibit presymptomatic brain MRI changes. Sixty-six Chamorro subjects had neurocognitive assessment and volumetric MRI. MRI brain volumes differed between diagnostic groups (GD, PDC, control) and according to family history. Chamorros with a family history of PDC or dementia may have increased brain atrophy, suggesting a hereditary susceptibility to neurodegenerative disorders.
Kaye
J A
JA
Departments of Neurology, Oregon Health and Science University, Portland, OR 97239, USA. kaye@ohsu.edu
Moore
M M
MM
Galasko
D
D
Craig
U K
UK
Adonay
R
R
Silbert
L C
LC
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D000690:Amyotrophic Lateral Sclerosis / Q000208:ethnology / Q000473:pathology* / Q000503:physiopathology; D001284:Atrophy / Q000208:ethnology / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology*; D015331:Cohort Studies; D003704:Dementia / Q000208:ethnology / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006141:Guam / Q000208:ethnology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000208:ethnology / Q000473:pathology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis