title: Potential mechanisms and clinical significance of global cerebral edema following aneurysmal subarachnoid hemorrhage.
abstract: In an attempt to elucidate the pathophysiology and clinical significance of global cerebral edema (GCE) following aneurysmal subarachnoid hemorrhage (SAH), the authors explored potential mechanisms and reviewed findings associated with this phenomenon. Admission computed tomography (CT) scans show GCE in up to 20% of patients experiencing aneurysmal SAH. This edema is likely to have been initiated by transient global ischemia, as indicated by an association between ictal loss of consciousness and the development of edema. A further cascade of events, including a rise in intracranial pressure and compromise of the blood-brain barrier, are also likely contributors. Clinically, GCE on CT after aneurysmal SAH is predictive of a poor outcome. Further investigation is needed to gain a full understanding of edema development following SAH, with the hope that the knowledge can be used to influence treatment positively and improve outcome.
authors.affiliation: Department of Neurosurgery, Columbia University, New York, New York 10032, USA. jdm32@columbia.edu
authors.forename: J
authors.initials: J
authors.lastname: Mocco
authors.forename: Carlton S
authors.initials: CS
authors.lastname: Prickett
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Komotar
authors.forename: E Sander
authors.initials: ES
authors.lastname: Connolly
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Mayer
mesh_terms: D001812:Blood-Brain Barrier / Q000503:physiopathology; D001929:Brain Edema / Q000209:etiology*; D018450:Disease Progression; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications*; D007427:Intracranial Pressure / Q000502:physiology; D008954:Models, Biological; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D013997:Time Factors