Tobacco smoking and the ADRA2A C-1291G polymorphism.
The aim of the present study is to test for possible associations between the C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) with tobacco smoking and alcohol dependence. The genotype and allele frequencies were compared in three groups of European-derived Brazilian males: individuals with co-occurrence of tobacco smoking and alcohol dependence (N = 110), with tobacco smoking (N = 121) and controls (N = 114). The frequency of the G allele was higher in the group with both conditions, intermediate among subjects with smoking, and lower among controls (chi(2) = 8.00; p = 0.02). The chi(2) partitioning did not reveal significant differences between the sample with the two conditions and the sample of smokers (chi(2) = 0.82; p = 0.36). Combining both groups, the difference to the non-smoking controls is higher than the one observed in the three-groups analysis (chi(2) = 7.18; p = 0.007). The results suggest a role for the ADRA2A C-1291G polymorphism, notably the G allele, in the predisposition to tobacco smoking. The influence of the ADRA2A gene in nicotine and other substance dependencies should be more extensively assessed in future studies.
Prestes
A P
AP
Department of Genetics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, Rs, Brazil.
Marques
F Z C
FZ
Hutz
M H
MH
Roman
T
T
Bau
C H D
CH
D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000235:genetics; D000483:Alleles; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D012907:Smoking / Q000235:genetics*
C547768:ADRA2A protein, human; D018341:Receptors, Adrenergic, alpha-2; D004247:DNA