Action of ethanol low doses on heart rate variability following intravenous administration in rabbits.
Effects of low ethanol doses on the vagosympathetic mechanisms of heart rate regulation were studied in rabbits. Analysis of heart rate variability showed that single intravenous administration of 0.5 mg/kg ethanol caused a higher probability of heart electrophysiological instability in sympathicotonics in contrast to vagotonics. This was associated with activation of the whole complex of regulatory mechanisms. In vagotonics, perturbations in power spectrum indicated on rapidly shunting of regulatory activity from lower to high levels of regulatory mechanisms to realize a "first class" undifferentiated response on stress induction. Sympathicotonics were unready to ethanol intravenous administration that resulted in reduction of all spectral component. Intravenous administration of ethanol caused a higher probability of heart electrophysiological instability in sympathicotonics then in vagotonics. It is important to consider these differences for therapeutic application of ethanol to some acute poisoning (methyl alcohol, ethylene glycol).
Khvedelidze
M
M
Research Centre of Radiobiology and Radiation Ecology, Tbilisi, Georgia.
Chitanava
E
E
Nadareishvili
D
D
Jiqia
G
G
Gvasalia
M
M
D000818:Animals; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000294:innervation; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000187:drug effects*; D014630:Vagus Nerve / Q000187:drug effects*
D000431:Ethanol