title: Three novel sterols isolated from Selaginella tamariscina with antiproliferative activity in leukemia cells.
abstract: Three new sterols, 3beta,16alpha-dihydroxy-5alpha,17beta-cholestan-21-carboxylic acid (1), 3beta-acetoxy-16alpha-hydroxy-5alpha,17beta-cholestan-21-carboxylic acid (2) and 3beta-(3-hydroxybutyroxy)-16alpha-hydroxy-5alpha,17beta-cholestan-21-carboxylic acid (3) were isolated from Selaginella tamariscina (Beauv.) Spring (Selaginellaceae). Their structures were elucidated based on NMR analyses. The growth inhibitory effects and differentiation induction abilities of compounds 1 - 3 were determined in human leukemia HL-60 cells. Compound 1 was more effective than compounds 2 and 3 in inhibiting cell growth, but compound 3 was more effective than compounds 1 and 2 in enhancing induction of all- trans-retinoic acid differentiation.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China.
authors.forename: Liang-liang
authors.initials: LL
authors.lastname: Gao
authors.forename: Shi-liang
authors.initials: SL
authors.lastname: Yin
authors.forename: Zhan-lin
authors.initials: ZL
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Sha
authors.forename: Yue-hu
authors.initials: YH
authors.lastname: Pei
authors.forename: Guang
authors.initials: G
authors.lastname: Shi
authors.forename: Yong-kui
authors.initials: YK
authors.lastname: Jing
authors.forename: Hui-ming
authors.initials: HM
authors.lastname: Hua
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D049109:Cell Proliferation / Q000187:drug effects*; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D032503:Selaginellaceae
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts