Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population.
The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene. FHIT performed a crucial function in the tumorigenesis of lung cancer. The inactivation of FHIT via genetic alterations, including the chromosomal deletions and aberrant transcription, are often associated with lung cancer. In this study, the association between FHIT and lung cancer development was evaluated in a study of Korean patients. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed. Logistic regression analyses were conducted in order to characterize the association between FHIT polymorphisms and lung cancer risk. Via direct sequencing in 24 Korean individuals, 27 sequence variants were identified. Eleven of these polymorphisms were selected for a larger scale genotyping (n = 595). Our finding indicated that the polymorphisms and haplotypes in the FHIT gene are not associated with lung cancer in the Korean population.
Jung
Hae-Yun
HY
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
Sung
Jae Sook
JS
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
Whang
Young Mi
YM
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
Shin
Hyoung Doo
HD
Department of Genetic Epidemiology, SNP Genetics, Inc., Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, 371-28 Gasan-Dong, Geumcheon-Gu, Seoul, Korea.
Park
Byung Lae
BL
Department of Genetic Epidemiology, SNP Genetics, Inc., Rm 1407, 14th floor, Complex B, WooLim Lion's Valley, 371-28 Gasan-Dong, Geumcheon-Gu, Seoul, Korea.
Kim
Jun Suk
JS
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
Shin
Sang Won
SW
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
Seo
Hee Yun
HY
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
Sung
Hwa Jung
HJ
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
Choi
In Keun
IK
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
Oh
Sang Cheul
SC
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
Seo
Jae Hong
JH
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea.
Kim
Yeul Hong
YH
Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University College of Medicine, 126-1, Anam-dong 5Ga, Sungbuk-Gu, Seoul, 136-705, Korea. yhk0215@korea.ac.kr.
D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk; D017422:Sequence Analysis, DNA; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase