Proteinuria of nonautoimmune origin in wild-type FVB/NJ mice.
FVB/NJ mice frequently are used as transgenic hosts, but the suitability of this genetic background for transgenic and congenic models of systemic autoimmunity have not been reported. In this study, FVB/NJ mice were evaluated for the presence of serum autoantibodies and autoimmune kidney pathology. Previously unreported albuminuria was observed in aged female FVB/NJ mice; however, serum autoantibody testing, light microscopic evaluation of differentially stained renal sections, and evaluation of renal sections for immunoglobulin deposits revealed that the albuminuria was not of autoimmune etiology. Anecdotally, multiple characteristics of the FVB/NJ strain, including albuminuria, cholesterolemia, mild podocyte foot process effacement in aged female FVB/NJ kidneys and predisposition to enhanced Th2 immune responses, is reminiscent of human minimal change nephrotic syndrome (MCNS). We propose that mapping of genetic polymorphisms that are responsible for these traits in FVB/NJ mice may lead to increased understanding of mild nephrotic syndromes including MCNS and other proteinurias.
Maier
Shannon M
SM
Arthritis and Immunology Program, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Gross
Joanne K
JK
Hamlin
Kassie L
KL
Maier
Julie L
JL
Workman
Jennifer L
JL
Kim-Howard
Xana R
XR
Schoeb
Trenton R
TR
Farris
A Darise
AD
D000419:Albuminuria / Q000378:metabolism*; D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood; D015551:Autoimmunity / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000652:urine; D004195:Disease Models, Animal; D005260:Female; D005455:Fluorescent Antibody Technique; D050533:Glomerular Basement Membrane / Q000378:metabolism / Q000648:ultrastructure; D007074:Immunoglobulin G / Q000378:metabolism; D007668:Kidney / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D046529:Microscopy, Electron, Transmission; D009402:Nephrosis, Lipoid / Q000276:immunology; D050199:Podocytes / Q000648:ultrastructure; D013047:Specific Pathogen-Free Organisms
D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D002784:Cholesterol; D003404:Creatinine