Genetic testing to identify high-risk populations for chemoprevention studies.
Human genetic variation data is now publicly available on a large scale, from both public and private discovery efforts. Datasets from the International Haplotype Map Consortium and Perlegen Sciences provide a level of knowledge about human genetic variation that is unprecedented. In combination with novel high-throughput genotyping technologies, these new resources will allow cancer prevention investigators to identify in a more precise way which genetic subsets of patients are likely to benefit most from chemoprevention and screening interventions.
Velasquez
Jonathan L
JL
Department of Medicine, Division of Hematology-Oncology, University of California, Irvine, CA 92697, USA. jvelasqu@uci.edu
Lipkin
Steven M
SM
D018890:Chemoprevention; D002986:Clinical Trials as Topic; D020022:Genetic Predisposition to Disease; D005821:Genetic Techniques; D005820:Genetic Testing / Q000379:methods / Q000639:trends*; D006239:Haplotypes; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors