title: Preparation, mechanical properties and in vitro degradability of wollastonite/tricalcium phosphate macroporous scaffolds from nanocomposite powders.
abstract: A new class of scaffolds with a gain size of 200 nm was prepared from wollastonite/tricalcium phosphate (WT) nanocomposite powders (termed "nano-sintered scaffolds") through a two-step chemical precipitation and porogen burnout techniques. For a comparison, WT scaffolds with a grain size of 2 microm were also fabricated from submicron composite powders (termed "submicron-sintered scaffolds") under the same condition. The resultant scaffolds showed porosities between 50+/-1.0% and 65+/-1.0% with a pore size ranging from 100 microm to 300 microm. The WT nano-sintered scaffolds exhibited compressive strength and elastic modulus values that were about twice that of their submicron-sintered counterparts. The in vitro degradation tests demonstrated that the degradability could be regulated by the grain size of bioceramics. The decreased specific surface area of pores in the nano-sintered scaffolds led to their reduced degradation rate. The mechanical properties of the nano-sintered scaffolds exhibited less strength loss during the degradation process. The WT macroporous nano-sintered scaffolds are a promising and potential candidate for bone reconstruction applications.
authors.affiliation: Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Faming
authors.initials: F
authors.lastname: Zhang
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
authors.forename: Kaili
authors.initials: K
authors.lastname: Lin
authors.forename: Jianxi
authors.initials: J
authors.lastname: Lu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes; D001842:Bone and Bones / Q000378:metabolism; D017610:Calcium Compounds / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D053761:Nanocomposites / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D011208:Powders; D017640:Silicates / Q000737:chemistry*; D013314:Stress, Mechanical; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D017610:Calcium Compounds; D002130:Calcium Phosphates; D011208:Powders; D017640:Silicates; C018392:tricalcium phosphate; C031293:calcium silicate