title: Effect of dimensions and volume of the prostate on cancer detection rate of 12 core prostate biopsy.
abstract: OBJECTIVE
  To evaluate if volume or any of the three dimensions of prostate influences cancer detection rate by 12-core transrectal ultrasound (TRUS) guided prostate biopsy.
  
  
  METHODS
  We have searched our database for patients who underwent 12 core TRUS guided prostate biopsy with PSA values between 4.0 and 9.9 ng/ml, benign digital exam and no suspicious lesions at TRUS. The measurements of three dimensions and volume of the prostate of 99 patients were correlated with cancer detection rates of biopsy.
  
  
  RESULTS
  There were no statistically significant differences between patients with prostate cancer or with benign histopathologic result for mean age, PSA and % PSA. Patients without cancer had a significantly higher mean prostate volume (58.88 cc) than patients with cancer (48.85 cc) (P = 0.038). A volume of 48.5 cc was determined as a cut-off value above which cancer detection rate decreases. Of the three dimensions, only the difference for the craniocaudal dimension between benign and malignant groups was marginally significant (P = 0.052).
  
  
  CONCLUSIONS
  With 12 core biopsy, cancer detection rate is lower in patients with prostates larger than 48.5 cc. Further studies comparing biopsy results with prostatectomy specimens can clarify whether these results necessitates higher number of cores for such patients.
authors.affiliation: Department of Urology, Ankara University, School Of Medicine, Camlitepe mah. Taskent str no 35/8 Kurtulus, Cankaya, Ankara, Turkey.
authors.forename: Eriz
authors.initials: E
authors.lastname: Ozden
authors.forename: Ahmet Tuncay
authors.initials: AT
authors.lastname: Turgut
authors.forename: Halit
authors.initials: H
authors.lastname: Talas
authors.forename: Onder
authors.initials: O
authors.lastname: Yaman
authors.forename: Orhan
authors.initials: O
authors.lastname: Göğüş
mesh_terms: D001707:Biopsy, Needle / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology*