Novel sulfated sesterterpene alkaloids from the marine sponge Fasciospongia sp.
Fasciospongines A (1) and B (2), two unusual sulfated sesterterpene alkaloids of an unprecedented structural class, have been isolated from the marine sponge Fasciospongia sp. The structures were elucidated on the basis of spectroscopic analysis. Compounds 1 and 2 displayed potent inhibitory activity to Streptomyces 85E in the hypha formation inhibition (HFI) bioassay.
Yao
Guangmin
G
Department of Chemistry and Biochemistry, College of Science and Engineering, University of Minnesota Duluth, 1039 University Drive, Duluth, Minnesota 55812, USA.
Chang
Leng Chee
LC
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes; D013302:Streptomyces / Q000187:drug effects*; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D054830:Sesterterpenes; D013463:Sulfuric Acid Esters; D013729:Terpenes; C522297:fasciospongine A; C522298:fasciospongine B