[Effect of Suanzaoren decoction on acute hepatic failure in mice].
OBJECTIVE
To investigate the effect of Suanzao nacute hepatic failure in mice.


METHODS
Acute liver failure was induced in male Kunming strain mice by enterocoelia injecting the animals with D-Gal-N and LPS. The mice in treatment groups were given corresponding drug 2 h before administration of D-Ga1-N and LPS, and the mice in control group were given the same dose of distilled water. The 24 h survival rate, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels were compared. Serum the levels of TNF-alpha and IL-1 and the levels of SOD, MDA, GR, GSH, NO and NOS in the liver were determined.


RESULTS
Treatment with suanzaoren decoction could increase the survival rate and improve the liver histological feather. Suanzaoren decoction inhibited the serum the levels of ALT, AST, TNF-alpha and IL-1, and reduced the levels of MDA, NO and NOS and increased the levels of GR and SOD in the liver.


CONCLUSIONS
Treatment with Suanzaoren decoction can suppress the D-Gal-N/LPS-induced acute hepatic failure. It may be the mechanism that Suanzaoren decocotion regulate the production of inflammatory cytokines and free radicals.
Zhu
Hai-peng
HP
Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Gao
Zhi-liang
ZL
Tan
De-ming
DM
Zhong
Yan-dan
YD
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D016207:Cytokines / Q000378:metabolism; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism; D005688:Galactosamine; D005978:Glutathione / Q000378:metabolism; D008070:Lipopolysaccharides; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D017114:Liver Failure, Acute / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000378:metabolism
D016207:Cytokines; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005609:Free Radicals; D008070:Lipopolysaccharides; C045965:suanzaorentang; D009569:Nitric Oxide; D008315:Malondialdehyde; D005688:Galactosamine; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione