Physiogenomic association of statin-related myalgia to serotonin receptors.
We employed physiogenomic analyses to investigate the relationship between myalgia and selected polymorphisms in serotonergic genes, based on their involvement with pain perception and transduction of nociceptive stimuli. We screened 195 hypercholesterolemic, statin-treated patients, all of whom received either atorvastatin, simvastatin, or pravastatin. Patients were classified as having no myalgia, probable myalgia, or definite myalgia, and assigned a myalgia score of 0, 0.5, or 1, respectively. Fourteen single nucleotide polymorphisms (SNPs) were selected from candidates within the 5-HT receptor gene families [5a-hydroxytryptamine receptor genes (HTR) 1D, 2A, 2C, 3A, 3B, 5A, 6, 7] and the serotonin transporter gene (SLC6A4). SNPs in the HTR3B and HTR7 genes, rs2276307 and rs1935349, respectively, were significantly associated with the myalgia score. Individual differences in pain perception and nociception related to specific serotonergic gene variants may affect the development of myalgia in statin-treated patients.
Ruaño
Gualberto
G
Genomas, Inc., 67 Jefferson Street, Hartford, Connecticut 06102, USA. g.ruano@genomas.net
Thompson
Paul D
PD
Windemuth
Andreas
A
Seip
Richard L
RL
Dande
Amit
A
Sorokin
Alexey
A
Kocherla
Mohan
M
Smith
Andrew
A
Holford
Theodore R
TR
Wu
Alan H B
AH
D000368:Aged; D000369:Aged, 80 and over; D000069059:Atorvastatin; D005260:Female; D023281:Genomics; D006538:Heptanoic Acids / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced* / Q000235:genetics; D010146:Pain / Q000139:chemically induced / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D017035:Pravastatin / Q000009:adverse effects / Q000627:therapeutic use; D011758:Pyrroles / Q000009:adverse effects / Q000627:therapeutic use; D011985:Receptors, Serotonin / Q000235:genetics*; D019821:Simvastatin / Q000009:adverse effects / Q000627:therapeutic use
D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D011985:Receptors, Serotonin; D000069059:Atorvastatin; D019821:Simvastatin; D017035:Pravastatin