Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats.
Hydro-ethanolic extract (70%) of Calotropis procera flowers was prepared and tested for its hepatoprotective effect against paracetamol-induced hepatitis in rats. Alteration in the levels of biochemical markers of hepatic damage like SGPT, SGOT, ALP, bilirubin, cholesterol, HDL and tissue GSH were tested in both treated and untreated groups. Paracetamol (2 g/kg) has enhanced the SGPT, SGOT, ALP, bilirubin and cholesterol levels and reduced the serum levels of HDL and tissue level of GSH. Treatment with hydro-ethanolic extract of C. procera flowers (200 mg/kg and 400 mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner.
Ramachandra Setty
S
S
Department of Pharmacology, S. C. S. College of Pharmacy, Davanagere, Karnataka, India. rssiddamsetty@rediffmail.com
Quereshi
Absar Ahmed
AA
Viswanath Swamy
A H M
AH
Patil
Tushar
T
Prakash
T
T
Prabhu
K
K
Veeran Gouda
A
A
D000082:Acetaminophen; D018712:Analgesics, Non-Narcotic; D000818:Animals; D031107:Calotropis; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D035264:Flowers; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D020011:Protective Agents; D000082:Acetaminophen