Effect of oppositely charged polymer and dissolution medium on swelling, erosion, and drug release from chitosan matrices.
The reasons for retarded release of naproxen sodium from the chitosan matrices at different pH include poor aqueous solubility of drug, the formation of a rate-limiting polymer gel barrier along the periphery of matrices, the interaction of naproxen sodium with protonated amino groups of chitosan, and the interaction of ionized amino groups of chitosan with ionized sulfate groups of kappa-carrageenan.
Bhise
Kiran S
KS
Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandwane, Pune, Maharashtra, India.
Dhumal
Ravindra S
RS
Chauhan
Bhaskar
B
Paradkar
Anant
A
Kadam
Shivajirao S
SS
D002351:Carrageenan / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D009288:Naproxen / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility
D065347:Hypromellose Derivatives; D009288:Naproxen; D002351:Carrageenan; D008747:Methylcellulose; D048271:Chitosan