Biscembranoids and their probable biogenetic precursor from the Hainan soft coral Sarcophyton tortuosum.
Five novel biscembranoids, ximaolides A-E (2-6), and their proposed biogenetic precursor, methyl tortuosoate (1), were isolated from the Hainan soft coral Sarcophyton tortuosum. The structures of compounds 1-6 were elucidated by spectroscopic methods, mainly NMR techniques. The relative stereochemistry of biscembranoids 2 and 6 was secured by X-ray diffraction analysis, whereas the relative configurations of chiral centers in compounds 1, 3, 4, and 5 have been suggested by both biogenetic considerations and NOESY experiments.
Jia
Rui
R
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Zu Chong Zi Road 555, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Guo
Yue-Wei
YW
Chen
Ping
P
Yang
Yi-Ming
YM
Mollo
Ernesto
E
Gavagnin
Margherita
M
Cimino
Guido
G
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure
D004224:Diterpenes; C522143:methyl tortuosoate