Rhodium(I)-catalyzed hydroaminomethylation of 2-isopropenylanilines as a novel route to 1,2,3,4-tetrahydroquinolines.
A new atom economical approach for the preparation of 1,2,3,4-tetrahydroquinolines can be achieved by means of the intramolecular hydroaminomethylation of 2-isopropenylanilines, mediated by an ionic diamino rhodium catalyst that does not require phosphine--this reaction is highly chemo- and regioselective, and it occurs in good isolated yields.
Vieira
Tiago O
TO
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.
Alper
Howard
H