Attenuation of MDMA-induced hyperthermia by ethanol in rats depends on ambient temperature.
In rats, at ambient temperatures of 21-23 degrees C, ethanol can attenuate the hyperpyretic effects of MDMA. We assessed if this attenuation holds true at a high ambient temperature. Rats were given MDMA (6.6 mg/kg i.p.) with or without ethanol (1.5 g/kg i.p.) at a room temperature of 32 degrees C. In the MDMA and ethanol+MDMA rats, body temperatures rose to about 42 degrees C after 60 min; all these rats had died after 120 min. At 23 degrees C, however, there was no lethality and ethanol reduced the hyperthermia. Thus, the effects of ethanol on MDMA-induced hyperthermia are related to ambient temperature.
Cassel
Jean-Christophe
JC
LINC UMR 7191, Université Louis Pasteur-CNRS, Institut Fédérératif de Recherche 37-GDR CNRS 2905, 12 rue Goethe, F-67000 Strasbourg, France. jean-christophe.cassel@psycho-ulp.u-strasbg.fr
Ben Hamida
Sami
S
Jones
Byron C
BC
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004195:Disease Models, Animal; D000431:Ethanol / Q000494:pharmacology*; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D051381:Rats; D020318:Rats, Long-Evans; D013696:Temperature; D013997:Time Factors
D018712:Analgesics, Non-Narcotic; D000431:Ethanol; D018817:N-Methyl-3,4-methylenedioxyamphetamine