title: Preparation of an electrodeposited hydroxyapatite coating on titanium substrate suitable for in-vivo applications.
abstract: In this paper the porous hydroxyapatite coating on Ti implant materials was prepared by the process of electrodeposition, hydrothermal and sinter. The surface morphology, bond strength and thickness of HA coatings were investigated by SEM, AFM, and its biocompatibility was evaluated by cytotoxicity experiments and implant experiments, respectively. Results showed that (1) The HA coatings was 50 microm thickness and adhered on the Ti substrate strongly, which bond strength reached 38 MPa. AFM analysis showed that the HA coating was porous structure, in which the mean pore size was 236.5 microm, (2) Cytotoxicity experiments and implant experiments showed that HA-coated Ti implant materials has little cytotoxicity in vitro and little inflammatory reaction in vivo, and there were no statistically disparity between HA-coated Ti implant and titanium implant materials of clinical application (p>0.05), which demonstrated that HA-coated Ti has a good biocompatibility.
authors.affiliation: State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan 410083, PR China. huangsp1@mail.csu.edu.cn
authors.forename: Suping
authors.initials: S
authors.lastname: Huang
authors.forename: Kechao
authors.initials: K
authors.lastname: Zhou
authors.forename: Baiyun
authors.initials: B
authors.lastname: Huang
authors.forename: Zhiyou
authors.initials: Z
authors.lastname: Li
authors.forename: Shaihong
authors.initials: S
authors.lastname: Zhu
authors.forename: Guohui
authors.initials: G
authors.lastname: Wang
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods*; D005434:Flow Cytometry; D007249:Inflammation; D008422:Materials Testing; D051379:Mice; D018625:Microscopy, Atomic Force; D011312:Pressure; D013499:Surface Properties; D013552:Swine; D023822:Tissue Engineering / Q000379:methods*; D014025:Titanium / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D017886:Durapatite; D014025:Titanium