Palladium-catalyzed stereoselective formation of alpha-O-glycosides.
A novel method for palladium-catalyzed stereoselective formation of alpha-O-glycosides has been developed. This strategy relies on the palladium-biaryl phosphine catalyst-glycal donor complexation to control the anomeric selectivity. It does not depend on the nature of the protecting groups on the substrates, thus eliminating the need for cumbersome protecting group manipulations.
Schuff
Brandon P
BP
Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59717, USA.
Mercer
Gregory J
GJ
Nguyen
Hien M
HM
D002384:Catalysis; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D006027:Glycosides; D010165:Palladium