Genes in context: probing the genetics of fracture resistance.
Fracture resistance is a complex trait dictated by bone volume, shape, internal architecture, and material performance of the calcified tissue itself, all of which may be influenced by a large number of different genetic and environmental processes. Quantitative Trait Loci analyses provide a sobering picture of this system and illustrate the importance of considering genes in context.
Sharkey
Neil A
NA
Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, USA. nas9@psu.edu
Lang
Dean H
DH
D000818:Animals; D049628:Body Size; D015519:Bone Density / Q000235:genetics*; D005260:Female; D050723:Fractures, Bone / Q000235:genetics* / Q000517:prevention & control; D020022:Genetic Predisposition to Disease; D008297:Male; D051379:Mice; D010641:Phenotype; D040641:Quantitative Trait Loci