Design of two liquid Ibuprofen-poloxamer-limonene or menthol preparations for dermal administration.
The purpose of our study was to prepare liquid forms of 20% ibuprofen in 30% poloxamer 407, while avoiding gel formation and to assess their drug diffusion-penetration (permeation) into the skin. Two series of poloxamer-based formulations were prepared, both containing ibuprofen and one of two terpenes: d-limonene and 1-menthol. A rheological characterization of all preparations made allowed their grouping in two modalities: gels and fluids. Data revealed a statistically superior enhanced permeation terpene-dependent of ibuprofen in fluid preparations, specially the one containing d-limonene. Cumulative permeation in 24 hr was 2500 micro g/cm(2) and 4500 micro g/cm(2) for the 1-menthol and d-limonene, respectively, for fluid preparations as compared with 2000 micro g/cm(2) and 1600 micro g/ cm(2) for d-limonene and 1-menthol on gels and only 1200 micro g/cm(2) of the control solution (p < 0.05). Results postulate that a liquid 30% poloxamer-based preparation of ibuprofen with d-limonene is possible and that it may be useful as a topical preparation of ibuprofen.
González
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N
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México.
Sumano
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H
D000279:Administration, Cutaneous; D000465:Algorithms; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D053138:Cyclohexenes / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods*; D005782:Gels; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D000077222:Limonene; D008297:Male; D008610:Menthol / Q000737:chemistry*; D051379:Mice; D010539:Permeability; D020442:Poloxamer / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013696:Temperature; D013729:Terpenes / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D014783:Viscosity
D018712:Analgesics, Non-Narcotic; D053138:Cyclohexenes; D005782:Gels; D013729:Terpenes; D020442:Poloxamer; D008610:Menthol; D000077222:Limonene; D007052:Ibuprofen