title: Family history of psychiatric disorders and alcohol and substance misuse in patients with bipolar I disorder, substance use disorder, or both.
abstract: Family history data were collected on first-degree relatives of 78 patients with bipolar I disorder (BD) and substance use disorder (SUD), 47 with BD only, and 35 with SUD only. The prevalence of psychiatric disorders was significantly higher in first-degree relatives of patients with BD + SUD (64%) and BD (61%) compared with first-degree relatives of SUD patients (20%). The prevalence of alcohol misuse was significantly higher in first-degree relatives of patients with BD + SUD (23.1%) and SUD alone (28.6%) compared to first-degree relatives of patients with BD (4.3%). Our findings suggest that BD and SUD do not share familial risk factors.
authors.affiliation: Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita' di Pisa, Pisa, Italy. alfredosbrana@virgilio.it
authors.forename: Alfredo
authors.initials: A
authors.lastname: Sbrana
authors.forename: Jacopo V
authors.initials: JV
authors.lastname: Bizzarri
authors.forename: Paola
authors.initials: P
authors.lastname: Rucci
authors.forename: Chiara
authors.initials: C
authors.lastname: Gonnelli
authors.forename: Jacopo G
authors.initials: JG
authors.lastname: Massei
authors.forename: Laura
authors.initials: L
authors.lastname: Ravani
authors.forename: Jean
authors.initials: J
authors.lastname: Endicott
authors.forename: Jack D
authors.initials: JD
authors.lastname: Maser
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Cassano
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000453:epidemiology*; D001714:Bipolar Disorder / Q000453:epidemiology*; D015897:Comorbidity; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000453:epidemiology*