Radiology-Pathology Conference: pulmonary hyalinizing granuloma associated with lupus-like anticoagulant and Morvan's Syndrome.
Pulmonary hyalinizing granulomata are rare, noninfectious, fibrosing lesions of the lung, which can mimic metastatic disease radiographically. Their etiology is unknown, but they may be caused by an exaggerated immune response. We report the radiology, long clinical course, and pathology of a patient with pulmonary hyalinizing granuloma who presented with initially asymptomatic pulmonary nodules. Over a 10-year period, the patient developed multiple insidious autoimmune phenomena, including lupus anticoagulant, neuromyotonia, demyelinating sensorimotor polyneuropathy, and eventually, Morvan's syndrome. Such an association has not been previously published to our knowledge.
Winger
David I
DI
Department of Radiology, Winthrop-University Hospital, Mineola, NY, 11501, USA.
Spiegler
Peter
P
Trow
Terence K
TK
Goyal
Amit
A
Yu
Huiying
H
Yung
Elizabeth
E
Katz
Douglas S
DS
D017809:Fatal Outcome; D015769:Granuloma, Respiratory Tract / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D006818:Hyalin; D008137:Longitudinal Studies; D016682:Lupus Coagulation Inhibitor / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014057:Tomography, X-Ray Computed
D016682:Lupus Coagulation Inhibitor