Predictors of intrauterine insemination success.
Intrauterine insemination (IUI) remains a therapeutic option within means of the majority of infertile couples in Malaysia. Therefore additional information on predictors of IUI success in the local context would provide a more concrete basis for counseling patients on expectations and treatment options. A retrospective analysis of 297 couples who underwent 445 IUI cycles from Jan 2005-Mar 2006 was undertaken. Four fifths were Malay with a mean paternal and maternal age of 35.53 +/- 5.82 (range 24-59) and 33.02 +/- 4.69 (range 21-46) years respectively. Causes of infertility were idiopathic (50%), endometriosis (17%) and anovulation/polycystic ovarian syndrome (15%). Almost 10% were oligoastenoteratozoospermic with another 23% oligozoospermic or astenozoospermic. Combined male and female factors occurred in 26%. A pregnancy rate (PR) of 9.4% per cycle; 14.1% per couple with a cumulative PR of 36.7% per 4 cycles was achieved. Those who became pregnant were significantly younger (31.29 +/- 4.43 vs. 33.21 +/- 4.68 years, p = 0.011) and had more follicles (13.95 +/- 9.72 vs. 11.43 +/- 6.67, p = 0.029) at the time of insemination. PR depreciated with maternal age and semen quality. Maternal and paternal age was inversely correlated to the number of follicles recruited (r = -0.30, p < 0.0005) and progressive sperm motility (r = -0.125, p = 0.013) respectively.
Zainul
M R R
MR
Department of O&G, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak 56000, Cheras, Kuala Lumpur.
Ong
F B
FB
Omar
M H
MH
Ng
S P
SP
Nurshaireen
A
A
Rahimah
M D
MD
Mariam
S
S
Zolaidah
M
M
Sharifah-Teh
N S M N
NS
Saniros
A
A
Hasnita
B
B
D000328:Adult; D000367:Age Factors; D005260:Female; D006801:Humans; D007246:Infertility; D007315:Insemination, Artificial / Q000379:methods* / Q000592:standards; D008296:Malaysia; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013076:Sperm Count; D013081:Sperm Motility; D016896:Treatment Outcome