title: Myocardial iron loading by magnetic resonance imaging T2* in good prognostic myelodysplastic syndrome patients on long-term blood transfusions.
abstract: Magnetic resonance imaging (MRI) was used to quantify myocardial iron loading by T2* in 11 transfusion-dependent good prognostic myelodysplastic syndrome (MDS) patients. Myocardial T2*, left ventricular function and hepatic T2* were measured simultaneously. Patients had been on transfusion therapy for 13-123 months and had serum ferritin levels of 1109-6148 microg/l at the time of study. Five patients had not commenced iron chelation and had been transfused with a median of 63 red cell units and had a median serum ferritin level of 1490 microg/l. Six patients were on iron chelation and had been transfused with a median of 112 red cell units and had a median serum ferritin level of 4809 mug/l. Hepatic iron overload was mild in two, moderate in seven and severe in two patients. The median liver iron concentration was 5.9 mg/g dry weight in chelated patients and 9.5 mg/g in non-chelated patients (P = 0.17; not significant). Myocardial T2* indicated absent iron loading in 10/11 patients (91%; 95% confidence interval 62-98%) and borderline-normal in one patient. Left ventricular function was normal in all patients. No correlation was observed between increasing serum ferritin levels, hepatic iron overload and myocardial T2*. A long latent period relative to hepatic iron loading appears to predate the development of myocardial iron loading in transfusion-dependent MDS patients.
authors.affiliation: Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK.
authors.forename: Joseph
authors.initials: J
authors.lastname: Chacko
authors.forename: Dudley J
authors.initials: DJ
authors.lastname: Pennell
authors.forename: Mark A
authors.initials: MA
authors.lastname: Tanner
authors.forename: Terry J
authors.initials: TJ
authors.lastname: Hamblin
authors.forename: Beatrix
authors.initials: B
authors.lastname: Wonke
authors.forename: Terry
authors.initials: T
authors.lastname: Levy
authors.forename: Peter W
authors.initials: PW
authors.lastname: Thomas
authors.forename: Sally B
authors.initials: SB
authors.lastname: Killick
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005293:Ferritins / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000627:therapeutic use; D019190:Iron Overload / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000378:metabolism / Q000628:therapy*; D009206:Myocardium / Q000378:metabolism*; D011379:Prognosis; D011446:Prospective Studies; D065227:Transfusion Reaction
chemical_list: D007502:Iron Chelating Agents; D005293:Ferritins; D007501:Iron