title: Impact of diagnostic delay in testis cancer: results of a large population-based study.
abstract: OBJECTIVE
  Testis cancer is the most common cancer in young men, and its incidence continues to rise. Even if prognosis is considered as good, a group with bad prognosis still remains. Diagnostic delay (DD), defined as the time elapsing from the onset of tumour symptoms to the day of diagnosis, is a way to evaluate the rapidity of diagnosis. We assessed the relationship between DD, disease stage, and survival rate.
  
  
  METHODS
  A series of 542 patients diagnosed with a germ cell tumour between 1983 and 2002 at health facilities in the Midi-Pyrenees region, southwest France, were asked about DD. We analysed DD together with data regarding the disease (histologic type, stage), its treatments, and prognosis (impact on survival).
  
  
  RESULTS
  Mean DD was longer in seminoma (4.9+/-6.1 mo) than in non-seminomatous germ cell tumour (NSGCT; 2.8+/-4.0 mo). DD was correlated with disease stage for the whole population (p=0.014) and for NSGCT (p=0.0009), but not for seminoma. DD had a significant impact on the 5-yr survival rate in the overall population (p=0.001) and in the NSGCT group (p=0.001), but not in the seminoma group. Global trends in mean DD did not change over the 20-yr study period, but we observed a slight decrease during the last decade.
  
  
  CONCLUSIONS
  DD is highly correlated with stage and survival in NSGCT. Urologists should promote programmes to enhance awareness and knowledge of testis cancer, so the diagnosis can be made more rapidly.
authors.affiliation: Human Fertility Research Group, Paule de Viguier Hospital, Toulouse University III, France; Urology and Andrology Department, Paule de Viguier Hospital, Toulouse, France. huyghe.e@chu-toulouse.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Huyghe
authors.forename: Audrey
authors.initials: A
authors.lastname: Muller
authors.forename: Roger
authors.initials: R
authors.lastname: Mieusset
authors.forename: Louis
authors.initials: L
authors.lastname: Bujan
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Bachaud
authors.forename: Christine
authors.initials: C
authors.lastname: Chevreau
authors.forename: Pierre
authors.initials: P
authors.lastname: Plante
authors.forename: Patrick
authors.initials: P
authors.lastname: Thonneau
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011634:Public Health; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D013997:Time Factors