title: Efficacy of tulathromycin or enrofloxacin for initial treatment of naturally occurring bovine respiratory disease in feeder calves.
abstract: After undergoing arrival processing at one of two commercial feedlots, feeder calves with clinical signs of bovine respiratory disease (BRD) were randomly assigned to receive either tulathromycin (2.4 mg/kg SC) or enrofloxacin (12.5 mg/kg SC). Additional therapy for calves that did not respond to initial treatment followed a prescribed course. Initial treatment with tulathromycin resulted in significantly higher (P = .009 and P = .031 at sites 1 and 2, respectively) therapeutic success (87.9% and 80%, respectively) than did initial treatment with enrofloxacin (70.2% and 62.5%, respectively). Animals treated with tulathromycin also had fewer subsequent treatments and higher weight gains compared with those treated with enrofloxacin.
authors.affiliation: Pfizer Animal Health, Kalamazoo, MI 49001, USA.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Robb
authors.forename: Cassius M
authors.initials: CM
authors.lastname: Tucker
authors.forename: Lane
authors.initials: L
authors.lastname: Corley
authors.forename: W Lawrence
authors.initials: WL
authors.lastname: Bryson
authors.forename: Karen C
authors.initials: KC
authors.lastname: Rogers
authors.forename: Kynan
authors.initials: K
authors.lastname: Sturgess
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Bade
authors.forename: Bruce
authors.initials: B
authors.lastname: Brodersen
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D048090:Bovine Respiratory Disease Complex / Q000188:drug therapy*; D002417:Cattle; D003120:Colorado; D004187:Disaccharides / Q000008:administration & dosage / Q000627:therapeutic use*; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D007279:Injections, Subcutaneous / Q000662:veterinary; D012008:Recurrence; D013781:Texas; D016896:Treatment Outcome; D015430:Weight Gain; D018942:Macrolides
chemical_list: D000900:Anti-Bacterial Agents; D004187:Disaccharides; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D006571:Heterocyclic Compounds; C485204:tulathromycin; D018942:Macrolides