title: Major depressive disorder and inflammatory markers in elderly patients with heart failure.
abstract: The authors evaluated levels of inflammatory markers in 34 chronic heart failure (CHF) out-patients age 65 years and over, with (N=18) and without (N=16) major depressive disorder (MDD), and healthy-control subjects (N=13). Patients with CHF had left-ventricular ejection fractions <0.40 and were in the New York Heart Association functional class II or III. The authors used the SCID DSM-IV to diagnosis MDD. High-sensitivity C-reactive protein levels were significantly higher in patients with CHF and MDD as compared with healthy-control subjects. No differences regarding tumor necrosis factor(alpha) or interleukin(6) were found among the three groups.
authors.affiliation: Heart Institute, University of São Paulo School of Medicine, São Paulo, SP, Brazil.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Andrei
authors.forename: Renerio
authors.initials: R
authors.lastname: Fraguas
authors.forename: Renata M S
authors.initials: RM
authors.lastname: Telles
authors.forename: Tânia C T F
authors.initials: TC
authors.lastname: Alves
authors.forename: Celia M C
authors.initials: CM
authors.lastname: Strunz
authors.forename: Amit
authors.initials: A
authors.lastname: Nussbacher
authors.forename: Jairo
authors.initials: J
authors.lastname: Rays
authors.forename: Dan V
authors.initials: DV
authors.lastname: Iosifescu
authors.forename: Mauricio
authors.initials: M
authors.lastname: Wajngarten
mesh_terms: D000368:Aged; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D015995:Prevalence; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein