title: Therapeutic results for 100 patients with cancer of the mobile tongue treated with low dose rate interstitial irradiation.
abstract: OBJECTIVE
  To evaluate the conservativeness of low dose rate interstitial irradiation (LII) for cancer of the mobile tongue.
  
  
  METHODS
  Between 1975 and 2002, 100 consecutive patients (71 men, 29 women) underwent LII as curative treatment. Stages were I/IIIII/IV = 16/63/16/4. Seventy-one cases were treated with LII alone and 29 cases treated combined with external irradiation. Median total dose of LH was 70 Gy/7 days.
  
  
  RESULTS
  Overall, 5- and 10-year local control and LII-treated patients' survival rates were 93% and 91%, 64% and 57%, respectively. Delayed neck metastases were observed in 21% of initially N0 cases, 56% of which could be salvaged by operation. Early stage and well-differentiated tumors carried better prognoses.
  
  
  CONCLUSIONS
  LII of cancers of the mobile tongue results in good local control and survival. With careful monitoring of patients to ensure early detection of delayed metastases, LII should allow organ conservation and yield favourable therapeutic results compared with those of surgery.
authors.affiliation: Department of Oral Surgery, Tokyo Metropolitan Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Karasawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Komiya
authors.forename: Nahoko
authors.initials: N
authors.lastname: Hanyu
authors.forename: Masahiko
authors.initials: M
authors.lastname: Okamoto
authors.forename: Ta-Chen
authors.initials: TC
authors.lastname: Chang
authors.forename: Yurie
authors.initials: Y
authors.lastname: Kiguchi
authors.forename: Ikuhiro
authors.initials: I
authors.lastname: Uchida
authors.forename: Shun'ichi
authors.initials: S
authors.lastname: Yoshida
authors.forename: Seiji
authors.initials: S
authors.lastname: Asoda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000556:secondary; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy*; D016896:Treatment Outcome