[Beta-amyloid peptide influences behavioral plasticity in terrestrial snail].
Influence of neurotoxic fragment of beta-amyloid peptide (25-35) on Helix lucorum behavioral plasticity (sensitization and food-aversion learning) was investigated. After beta-amyloid peptide (25-35) injection a significant reduction of behavioral long-term sensitization was observed. It was found, that beta-amyloid peptide (25-35) may interfere with associative learning and memory. Our results clearly demonstrate that beta-amyloid peptide (25-35) may play a significant role in behavioral plasticity by chronically eliminating certain underlying forms of synaptic plasticity.
Korshunova
T A
TA
Samarova
E I
EI
Bravarenko
N I
NI
Balaban
P N
PN
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology; D007858:Learning / Q000187:drug effects*; D010446:Peptide Fragments / Q000633:toxicity*
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35)