Nonsurgical, radiofrequency collagen denaturation for stress urinary incontinence: retrospective 3-year evaluation.
Transurethral radiofrequency collagen denaturation, a nonsurgical treatment for stress urinary incontinence, reduces regional dynamic tissue compliance without causing tissue necrosis or gross tissue shrinkage, unlike transvaginal radiofrequency tissue ablation. This retrospective study evaluated long-term safety and efficacy in 21 patients from a 12-month, randomized controlled trial utilizing 3-day diaries and the Incontinence Quality of Life (I-QOL) survey. Significant increases in overall I-QOL scores 3 years or more post treatment was the primary end point. Secondary end points were reductions in frequency and severity of incontinence episodes. After 3 years, mean overall I-QOL score improvement was 12.7 (+/-26); 56% of patients achieved 50% or more reduction in frequency. No new adverse events occurred. These results indicate that radiofrequency collagen denaturation is safe and provides durable efficacy.
Appell
Rodney A
RA
Baylor College of Medicine, Scott Department of Urology, 6560 Fannin Street, Suite 2100, Houston, TX 77030, USA. rappell@bcm.edu
Singh
Gita
G
Klimberg
Ira W
IW
Graham
Christopher
C
Juma
Saad
S
Wells
W Glen
WG
Kanellos
Angelo
A
Reilley
Sandra F
SF
D003094:Collagen / Q000737:chemistry*; D004867:Equipment Design; D005500:Follow-Up Studies; D006801:Humans; D011489:Protein Denaturation; D011788:Quality of Life; D011846:Radio Waves; D012189:Retrospective Studies; D014521:Urethra / Q000528:radiation effects; D014550:Urinary Incontinence, Stress / Q000628:therapy*
D003094:Collagen