Interleukin-1alpha and -1beta promoter polymorphisms in Taiwanese patients with dementia.
BACKGROUND
Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1alpha -889 C/T and IL-1beta -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD).


METHODS
AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls (n = 209) were analyzed by means of genotype association method.


RESULTS
No significant difference in the genotype distribution of the analyzed single nucleotide polymorphisms was found between AD or VaD cases and controls. However, the frequency of the IL-1alpha -889 CT genotype was notably lower in VaD patients aged over 70 years than the age-matched controls (9.1 vs. 22.9%, p = 0.036) andtheIL-1alpha -889 CT genotype demonstrated a trend toward decrease in risk of developing VaD (odds ratio: 0.34; 95% confidence interval: 0.12-0.83, p = 0.026). Multivariate analysis revealed that the IL-1beta -511T-carrying genotype slightly strengthens the negative association of the IL-1alpha -889 CT genotype with VaD (odds ratio: 0.26; 95% confidence interval: 0.08-0.79, p = 0.024).


CONCLUSIONS
Our data suggest a protective role of the IL-1alpha -889 CT genotype in VaD susceptibility among Taiwanese aged over 70 years.
Wang
Hsiu-Kuan
HK
Department of Life Science, National Taiwan Normal University, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan, ROC.
Hsu
Wen-Chuin
WC
Fung
Hon-Chung
HC
Lin
Jun-Cheng
JC
Hsu
Hai-Pei
HP
Wu
Yih-Ru
YR
Hsu
Yuying
Y
Hu
Fen-Ju
FJ
Lee-Chen
Guey-Jen
GJ
Chen
Chiung-Mei
CM
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000276:immunology; D015140:Dementia, Vascular / Q000235:genetics* / Q000276:immunology; D005260:Female; D006580:Genetic Carrier Screening; D005838:Genotype; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012306:Risk; D013624:Taiwan
D053582:Interleukin-1alpha; D053583:Interleukin-1beta