Double helical oligoresorcinols specifically recognize oligosaccharides via heteroduplex formation through noncovalent interactions in water.
We report on the oligosaccharide recognition through noncovalent interactions in water based on a unique supramolecular homoduplex-to-heteroduplex transformation of the oligoresorcinol nonamer as a fully artificial receptor. The oligoresorcinol forms a double helix in water, which unravels and entwines upon complexation with specific oligosaccharides with a particular chain length and glucosidic linkage pattern, thus generating the heteroduplex with an excess one-handed helical conformation that can be readily monitored and further quantified by absorption, circular dichroism, and NMR spectroscopies.
Goto
Hidetoshi
H
Yashima Super-structured Helix Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST), Creation Core Nagoya 101, 2266-22 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-0003, Japan.
Furusho
Yoshio
Y
Yashima
Eiji
E
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002942:Circular Dichroism; D017666:Deuterium Oxide / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D004058:Diffusion; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009844:Oligosaccharides / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014867:Water / Q000737:chemistry
D003911:Dextrans; D009844:Oligosaccharides; D012118:Resorcinols; D014867:Water; D017666:Deuterium Oxide