title: Two-component systems of Mycobacterium tuberculosis: structure-based approaches.
abstract: Mycobacterium tuberculosis contains few two-component systems compared to many other bacteria, possibly because it has more serine/threonine signaling pathways. Even so, these two-component systems appear to play an important role in early intracellular survival of the pathogen as well as in aspects of virulence. In this chapter, we discuss what has been learned about the mycobacterial two-component systems, with particular emphasis on knowledge gained from structural genomics projects.
authors.affiliation: Hamburg Outstation, European Molecular Biology Laboratory (EMBL), Hamburg, Germany.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Tucker
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Nowak
authors.forename: Jens Preben
authors.initials: JP
authors.lastname: Morth
mesh_terms: D001671:Biochemistry / Q000379:methods; D002470:Cell Survival; D018360:Crystallography, X-Ray / Q000379:methods; D004247:DNA / Q000737:chemistry; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D023281:Genomics / Q000379:methods*; D008829:Microbiology; D008957:Models, Genetic; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D012995:Solubility; D014774:Virulence
chemical_list: D004247:DNA