A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery.
We show that the use of multiple photochemistries is necessary to ensure diverse immobilisation of small molecules for binding of polypeptides using phage display and antibody libraries.
Dilly
Suzanne J
SJ
Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.
Bell
Matthew J
MJ
Clark
Andrew J
AJ
Marsh
Andrew
A
Napier
Richard M
RM
Sergeant
Martin J
MJ
Thompson
Andrew J
AJ
Taylor
Paul C
PC
D015195:Drug Design; D019151:Peptide Library; D010455:Peptides / Q000378:metabolism; D010777:Photochemistry
D019151:Peptide Library; D010455:Peptides