title: Determination of metallic traces in kidneys, livers, lungs and spleens of rats with metallic implants after a long implantation time.
abstract: Metallic transfer from implants does not stop at surrounding tissues, and metallic elements may be transferred by proteins to become lodged in organs far from the implant. This work presents an in vivo study of metallic implant corrosion to measure metallic element accumulation in organs located far from the implant, such as kidneys, livers, lungs and spleens. The studied metallic implant materials were CoCr alloy, Ti, and the experimental alloy MA956 coated with alpha-alumina. The implants were inserted in the hind legs of Wistar rats. Analysis for Co, Cr, Ti and Al metallic traces was performed after a long exposure time of 12 months by Inductively Coupled Plasma (ICP) with Mass Spectrometry (MS). According to the results, the highest Cr and Ti concentrations were detected in spleens. Co is mainly found in kidneys, since this element is eliminated via urine. Cr and Ti traces increased significantly in rat organs after the long implantation time. The organs of rats implanted with the alpha-alumina coated experimental MA956 did not present any variation in Al content after 12 months, which means there was no degradation of the alumina layer surface.
authors.affiliation: Department of Orthopaedic Surgery, Hospital Universitario La Paz, Madrid 28046, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Rubio
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Garcia-Alonso
authors.forename: Concepcion
authors.initials: C
authors.lastname: Alonso
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Alobera
authors.forename: Celia
authors.initials: C
authors.lastname: Clemente
authors.forename: Luis
authors.initials: L
authors.lastname: Munuera
authors.forename: Maria Lorenza
authors.initials: ML
authors.lastname: Escudero
mesh_terms: D000535:Aluminum / Q000032:analysis; D000818:Animals; D002857:Chromium / Q000032:analysis; D003035:Cobalt / Q000032:analysis; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D013058:Mass Spectrometry / Q000379:methods; D008670:Metals / Q000032:analysis / Q000737:chemistry; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism*; D014025:Titanium / Q000032:analysis; D014131:Trace Elements / Q000032:analysis*
chemical_list: D008670:Metals; D014131:Trace Elements; D002857:Chromium; D003035:Cobalt; D000535:Aluminum; D014025:Titanium