title: Protective effects of wheat bran against diquat toxicity in male Fischer-344 rats.
abstract: After injection with 0.1 mmol diquat/kg body weight, survival time was markedly shorter in Fischer-344 rats fed a purified diet than in rats fed a regular diet, and much more severe hepatotoxicity and nephrotoxicity were observed in the former than in the latter. The longer the feeding period on the purified diet, the shorter the survival time after diquat administration. These results indicate that the purified diet lacked components present in the regular diet that had protective effects against diquat toxicity. These two diets had nearly the same composition and content of vitamins and minerals. We tested the ingredients of the regular diet to determine which ones reduce diquat toxicity. We found that wheat bran had a protective effect, but that rice bran and bean-curd refuse (okara) did not.
authors.affiliation: Laboratory of Animal Nutrition, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Higuchi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Naomi
authors.initials: N
authors.lastname: Kawasaki
authors.forename: Keiji
authors.initials: K
authors.lastname: Hamaoka
authors.forename: Sho
authors.initials: S
authors.lastname: Watabiki
authors.forename: Koichi
authors.initials: K
authors.lastname: Orino
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D004043:Dietary Fiber / Q000378:metabolism*; D004178:Diquat / Q000633:toxicity*; D006540:Herbicides / Q000633:toxicity*; D008297:Male; D012275:Oryza / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344; D017208:Rats, Wistar; D045730:Soy Foods
chemical_list: D004043:Dietary Fiber; D006540:Herbicides; D004178:Diquat