Prevalence and common genotypes of HCV infection in Sudanese patients with hepatosplenic schistosomiasis.
A cross-sectional hospital based study was carried out at the National Center for Gastrointestinal and Liver Disease in Khartoum, Sudan to determine the prevalence, common genotypes and risk factors for hepatitis C virus infection in Sudanese patients with hepatosplenic schistosomiasis. A total of 176 patients with hepatosplenic schistosomiasis were tested for HCV antibodies and 4.5% of the samples were reactive. PCR was positive in 2.3% of cases and genotype 4 was the major genotype isolated with subtypes 4, 4e, and 4c/4d. It is concluded that HCV was of low seroprevalence in the study population and that parenteral antischistosomal therapy was not a significant risk factor in transmission of infection in the Sudan.
Mudawi
H M Y
HM
Department of Internal Medicine, University of Khartoum, Khartoum, Sudan. hmudawi@hotmail.com
Smith
H M
HM
Fletcher
I A
IA
Fedail
S S
SS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology* / Q000821:virology; D018937:Hepatitis C Antibodies / Q000276:immunology; D006801:Humans; D008109:Liver Diseases, Parasitic / Q000150:complications; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012555:Schistosomiasis mansoni / Q000150:complications*; D016036:Seroepidemiologic Studies; D013158:Splenic Diseases / Q000150:complications; D013397:Sudan / Q000453:epidemiology
D018937:Hepatitis C Antibodies