Protective effect of pentoxifylline on growth plate in neonatal rats following long-term phototherapy.
We demonstrated previously that receiving long-term phototherapy was associated with early impairment of growth plate structure in neonatal rats, and oxidative stress may be the main risk factor for growth plate injury. The purpose of this study was to examine the histomorphometric effects of pentoxifylline treatment on the growth plate. Sixty weanling Sprague-Dawley rats were randomly separated into three equal groups. Group A, the control group, did not receive phototherapy and pentoxifylline. Groups B and C were exposed to phototherapy for 7 d. In addition to phototherapy, group C was also given pentoxifylline during the study period. Compared with zonal lengths on d 7 after initiation of phototherapy, group B had significantly lower values than group A for all zonal lengths (p < 0.001). Zonal lengths of growth plate were increased significantly with pentoxifylline treatment in group C for 7 d compared with group B (p < 0.001). After phototherapy, group B had significantly higher values than groups A and C for plasma malondialdehyde levels (p < 0.001). The pentoxifylline was found here to have some potential to reduce the effects of phototherapy on growth plate in neonatal rats at a relatively low dose.
Atabek
Mehmet Emre
ME
Department of Pediatric Endocrinology, School of Medicine, Selcuk University, 42080 Konya, Turkey. meatbek@hotmail.com
Pirgon
Ozgur
O
Esen
H Hasan
HH
D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants / Q000494:pharmacology*; D001846:Bone Development / Q000187:drug effects* / Q000528:radiation effects; D006132:Growth Plate / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects* / Q000528:radiation effects; D010431:Pentoxifylline / Q000494:pharmacology*; D010789:Phototherapy / Q000009:adverse effects*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000975:Antioxidants; D011837:Radiation-Protective Agents; D008315:Malondialdehyde; D010431:Pentoxifylline