Sinus floor elevation using autogenous bone or bone substitute combined with platelet-rich plasma.
OBJECTIVE
Sinus augmentation is a common approach for patients with severe alveolar ridge atrophy. However, autogenous bone sometimes results in donor site complications. Bone substitutes with platelet-rich plasma (PRP) promote early bone formation with autogenous bone. Use of PRP on autogenous bone and a bovine bone substitute were investigated in this split-mouth animal study.


METHODS
Premolars were extracted from minipigs. Each animal received sinus augmentation using a lateral approach with simultaneous insertion of 3 implants in each site. Groups were randomized using autogenous bone alone and combined with PRP or a bovine hydroxyapatite alone in combination with PRP.


RESULTS
Microradiographic findings in the autogenous group did not show significantly different rates by using autogenous bone alone or combined with PRP. Using the bovine hydroxyapatite as augmentation material only at 8 weeks, a nonsignificant effect in the PRP group could be seen. At all other observation periods, no significant influence was observed.


CONCLUSIONS
No significant influence of PRP was found.
Schlegel
Karl Andreas
KA
Department of Oral Maxillofacial Surgery, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany. andreas.schlegel@yahoo.de
Zimmermann
Robert
R
Thorwarth
Michael
M
Neukam
Friedrich-Wilhelm
FW
Klongnoi
Boworn
B
Nkenke
Emeka
E
Felszeghy
Endre
E
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000000981:diagnostic imaging / Q000379:methods*; D002417:Cattle; D003758:Dental Implantation, Endosseous / Q000379:methods; D017886:Durapatite / Q000627:therapeutic use; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000601:surgery*; D008852:Microradiography / Q000379:methods; D023421:Models, Animal; D053657:Platelet-Rich Plasma / Q000000981:diagnostic imaging*; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors
D001672:Biocompatible Materials; D018786:Bone Substitutes; D017886:Durapatite