title: Injection of triamcinolone acetonide into the posterior sub-tenon capsule for treatment of diabetic macular edema.
abstract: OBJECTIVE
  To compare eyes that received treatment with untreated fellow eyes to assess the effectiveness of injection of 20 mg of triamcinolone acetonide (TA) into the posterior sub-Tenon capsule for treatment of diabetic macular edema (DME).
  
  
  METHODS
  Nine adult patients (mean age, 60.4 years) with DME in both eyes were followed up for 3 months after unilateral treatment. We compared central macular thickness before and after treatment with those of the untreated fellow eye.
  
  
  RESULTS
  In 9 eyes injected with 20 mg of TA, the mean central macular thickness +/- SD was 624.8 +/- 173.7 microm before treatment. In the fellow eyes, it was 452.8 +/- 235.2 microm. There was no significant difference between the two groups (P=0.10, unpaired t-test). One month after injection, it was 434.0 +/- 120.7 microm in injected eyes (P=0.017, paired t-test) and 462.2 +/- 232.7 microm in fellow eyes (P=0.70, paired t-test), and after 3 months, the respective values were 423.1 +/- 186.3 microm (P=0.052, paired t-test) and 478.3 +/- 269.1 microm (P=0.65, paired t-test).
  
  
  CONCLUSIONS
  Injection of 20 mg of TA into the posterior sub-Tenon capsule effectively reduces macular thickening due to DME, at least in the short term.
authors.affiliation: Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan. jtoda-tky@umin.ac.jp
authors.forename: Junko
authors.initials: J
authors.lastname: Toda
authors.forename: Harumi
authors.initials: H
authors.lastname: Fukushima
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kato
mesh_terms: D000368:Aged; D003930:Diabetic Retinopathy / Q000188:drug therapy*; D005205:Fascia / Q000187:drug effects*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008266:Macula Lutea / Q000473:pathology; D008269:Macular Edema / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D041623:Tomography, Optical Coherence; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D014792:Visual Acuity / Q000502:physiology
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide