[Expression of CD147 and MMP-2 in human gliomas and its correlations with prognosis].
OBJECTIVE
To investigate the expressions of CD147 and MMP-2 in human gliomas and to study the relationship between their expression and prognosis.


METHODS
Immunohistochemistry SP methods were applied to detect the expression of CD147 and MMP-2 in 50 cases of gliomas and RT-PCR also applied to analyze the expression level of CD147 mRNA. The relationship between the expression level and the glioma prognosis were analyzed statistically depends on the follow-up investigation of the disease development.


RESULTS
The positive rates of CD147 and MMP-2 in human gliomas were 72. 0% and 78. 0%, and coexpression of CD147 and MMP-2 in gliomas was 70. 0%. CD147 protein was positively correlated with the expression of MMP-2 protein (r =0. 737, P<0. 01). CD147 mRNA expression was also detected in low and high grade gliomas by RT-PCR, but their expression levels were obviously enhanced in high grade gliomas. There was a significant difference in each grade gliomas. The higher expression of CD147, the shorter survival time of the patients. The variations were significant statistically.


CONCLUSIONS
There was positive correlation between the expressions of CD147, MMP-2 in human gliomas and the degree of malignancy and prognosis. CD147 and MMP-2 may be a prognostic factor of human gliomas and targets for chemotherapeutical strategies.
Li
Hao
H
Department of Neurosurgy, West China Hospital, Sichuan University, Chengdu 610041, China.
Chen
Jing
J
He
Min
M
Hui
Xu-hui
XH
Cai
Bo-wen
BW
Li
Yang
Y
D000328:Adult; D000368:Aged; D051926:Basigin / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
D012333:RNA, Messenger; D051926:Basigin; D020778:Matrix Metalloproteinase 2