title: Transthoracic Doppler echocardiographic assessment of left anterior descending coronary artery and intramyocardial artery predicts left ventricular remodeling and wall-motion recovery after acute myocardial infarction.
abstract: BACKGROUND
  Previous studies reported that a coronary flow velocity (FV) pattern with a rapid diastolic deceleration time (DDT) immediately after percutaneous coronary intervention implies advanced microvascular damage in patients who have experienced an acute myocardial infarction (AMI).
  
  
  METHODS
  Using transthoracic echocardiography, we recorded the coronary FV in the left anterior descending coronary artery (LAD) and the FV in the intramyocardial artery 2 days after successful percutaneous coronary intervention in 24 patients who had experienced an anterior AMI. We measured the DDT of the LAD and the intramyocardial artery. DDT of the LAD and the intramyocardial artery was detected in the anteroseptal lesion, the wall motion of which revealed severe hypokinesis or akinesis. We performed echocardiography during both the acute phase and 6 months after the AMI.
  
  
  RESULTS
  Patients were divided into two groups (group A: DDT of the LAD < or = 600 milliseconds [n = 10], group B: DDT of the LAD > or = 600 milliseconds [n = 14]). DDT of the LAD and the intramyocardial artery was significantly shorter for group A than group B (373 +/- 223 vs 786 +/- 105 milliseconds, P < .0001). In the acute phase, there were no significant differences in left ventricular (LV) wall-motion score index (WMSI), LV end-diastolic volume (EDV), or ejection fraction (WMSI: 2.38 +/- 0.24 vs 2.08 +/- 0.58, P = .20; LV EDV: 160 +/- 41 vs 154 +/- 34 mL; ejection fraction: 45 +/- 11 vs 46 +/- 5%). However, WMSI and LV EDV in group A were significantly greater than in group B (WMSI: 2.47 +/- 0.16 vs 1.84 +/- 0.57, P = .01; LV EDV: 198 +/- 28 vs 132 +/- 37 mL, P = .0004) and the ejection fraction in group A was significantly lower than in group B (38 +/- 9 vs 55 +/- 10%, P = .001) during the chronic phase.
  
  
  CONCLUSIONS
  In patients who had experienced an anterior AMI, we could predict wall-motion recovery of the infarcted area by using the coronary FV of the LAD and FV of the intramyocardial artery.
authors.affiliation: Division of Cardiology, Kobe General Hospital, Kobe, Japan. tomokot@kcgh.gr.jp
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tani
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Tanabe
authors.forename: Fumie
authors.initials: F
authors.lastname: Kureha
authors.forename: Minako
authors.initials: M
authors.lastname: Katayama
authors.forename: Makoto
authors.initials: M
authors.lastname: Kinoshita
authors.forename: Koichi
authors.initials: K
authors.lastname: Tamita
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Oda
authors.forename: Natsuhiko
authors.initials: N
authors.lastname: Ehara
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Kaji
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamamuro
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Morioka
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Kihara
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D023921:Coronary Stenosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D015150:Echocardiography, Doppler / Q000379:methods; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D011379:Prognosis; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000601:surgery*; D020257:Ventricular Remodeling