A polyvinyl alcohol core coil containing basic fibroblast growth factor evaluated in rabbits with aneurysms induced by elastase.
OBJECTIVE
The present study evaluates the effect of a novel coil with a polyvinyl alcohol (PVA) core that delivered basic fibroblast growth factor (bFGF) to aneurysms in rabbits induced by elastase.


METHODS
PVA was processed to form small threads and inserted into the central core of a primary coil (PVA-core coil). After immersion in saline or bFGF (500 or 2000 mug/ml), PVA-core coils were implanted into elastase-induced aneurysms in rabbits in vivo. Follow-up angiography was performed 4 and 8 weeks after embolization, and the effects were histologically semiquantified according to a grading scale.


RESULTS
Follow-up angiography showed that the coils did not compact or protrude and that clots did not form in any group. The score of gross neck healing was significantly higher in the 8-week 2000 bFGF group than in the 8-week PVA coil group (2.7 +/- 0.6 versus 0.0 +/- 0.0, P < 0.05). The dome healing score was significantly higher in the 4-week 2000 bFGF group than that of the 4-week PVA coil group (4.0 +/- 0.0 versus 2.7 +/- 0.6, P < 0.05). Cells positive for alpha-smooth muscle actin densely accumulated in the dome of the aneurysm embolized with PVA-core coils containing bFGF.


CONCLUSIONS
Implantation of the PVA-core coil containing bFGF accelerated tissue growth at the neck as well as in the dome of aneurysms induced by elastase in rabbits. These results suggested that PVA-core coils could prevent the recanalization of embolized aneurysms.
Tsumoto
Tomoyuki
T
Department of Neurological Surgery, Wakayama Medical University, Wakayama, Japan. Ttsumoto@chpnet.org
Matsumoto
Hiroyuki
H
Terada
Tomoaki
T
Tsuura
Mitsuharu
M
Itakura
Toru
T
Hamamoto
Tetsuya
T
D000818:Animals; D003131:Combined Modality Therapy; D004343:Drug Implants / Q000008:administration & dosage* / Q000737:chemistry*; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage* / Q000737:chemistry; D002532:Intracranial Aneurysm / Q000139:chemically induced / Q000628:therapy*; D010196:Pancreatic Elastase; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011817:Rabbits; D016896:Treatment Outcome
D004343:Drug Implants; D016222:Fibroblast Growth Factor 2; D011142:Polyvinyl Alcohol; D010196:Pancreatic Elastase