Functional heterogeneity of the "transporter" of electrogenic ionic pump of the Lumbricus terrestris somatic myocyte membrane.
Potential created by electrogenic ionic pumps under conditions of maximum activation in a warm standard ionic medium with K(+) after preincubation in cold potassium-free solution has two components: a higher ouabaine-insensitive "stationary" component, and a lower "regulatory" component sensitive to ouabaine, furosemide, and removal of Cl(-) or Ca(2+) from the medium. Functional heterogeneity of electrogenic ionic pumps is hypothesized implying the existence of two components: "stationary" (not regulated extracellularly) and "regulatory" (controlled and directly related to active Cl(-) transfer).
Volkov
E M
EM
Kazan State Medical University, Russian Ministry of Health, Russia. emvolkov@kzn.ru
Sabirova
A R
AR
Nurullin
L F
LF
Zefirov
A L
AL
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005665:Furosemide / Q000494:pharmacology; D018755:GABA Agonists / Q000145:classification / Q000494:pharmacology; D007477:Ions / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D032342:Muscle Cells / Q000187:drug effects* / Q000378:metabolism*; D009835:Oligochaeta / Q000378:metabolism / Q000502:physiology*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism / Q000494:pharmacology; D012508:Sarcolemma / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism / Q000494:pharmacology; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology
D002712:Chlorides; D003470:Culture Media; D004791:Enzyme Inhibitors; D018755:GABA Agonists; D007477:Ions; D049994:Sodium Potassium Chloride Symporter Inhibitors; D010042:Ouabain; D005665:Furosemide; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D002118:Calcium