title: Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16.
abstract: OBJECTIVE
  Vulnerability to the triggering of bipolar episodes by childbirth aggregates in families and may define a genetically relevant subtype of bipolar disorder. The authors conducted a search by systematic whole genome linkage scan for loci influencing vulnerability to bipolar affective puerperal psychosis.
  
  
  METHODS
  The authors selected families with bipolar disorder from their previous bipolar disorder genome scan, in which there was at least one family member with a manic or psychotic episode with an onset within 6 weeks of delivery. Individuals were coded as affected if they had been diagnosed with bipolar I disorder; bipolar II disorder; or schizoaffective disorder, bipolar type, according to DSM-IV. A total of 36 pedigrees contributed 54 affected sibling pairs to the cohort. A genome scan with 494 microsatellite markers was analyzed using GENEHUNTER and MAPMAKER/SIBS.
  
  
  RESULTS
  A genome-wide significant linkage signal was observed on chromosome 16p13, and a genome-wide suggestive linkage was observed on chromosome 8q24. No significant or suggestive linkage was observed in these regions in our original bipolar scan.
  
  
  CONCLUSIONS
  This study identifies chromosomal regions that are likely to harbor genes that predispose individuals to bipolar affective puerperal psychosis. The identification of susceptibility genes would enhance understanding of pathogenesis and offer the possibility of improvements in treatment and risk prediction.
authors.affiliation: Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN UK. jonesir1@cf.ac.uk
authors.forename: Ian
authors.initials: I
authors.lastname: Jones
authors.forename: Marian
authors.initials: M
authors.lastname: Hamshere
authors.forename: Jeanne-Marrie
authors.initials: JM
authors.lastname: Nangle
authors.forename: Philip
authors.initials: P
authors.lastname: Bennett
authors.forename: Elaine
authors.initials: E
authors.lastname: Green
authors.forename: Jess
authors.initials: J
authors.lastname: Heron
authors.forename: Ricardo
authors.initials: R
authors.lastname: Segurado
authors.forename: David
authors.initials: D
authors.lastname: Lambert
authors.forename: Peter
authors.initials: P
authors.lastname: Holmans
authors.forename: Aiden
authors.initials: A
authors.lastname: Corvin
authors.forename: Mike
authors.initials: M
authors.lastname: Owen
authors.forename: Lisa
authors.initials: L
authors.lastname: Jones
authors.forename: Michael
authors.initials: M
authors.lastname: Gill
authors.forename: Nick
authors.initials: N
authors.lastname: Craddock
mesh_terms: D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics*; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005190:Family; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008126:Lod Score; D010375:Pedigree; D010641:Phenotype; D011247:Pregnancy; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011644:Puerperal Disorders / Q000175:diagnosis / Q000235:genetics*; D012307:Risk Factors
chemical_list: D005819:Genetic Markers