title: Pamidronate treatment of chronic noninfectious inflammatory lesions of the mandible in children.
abstract: Noninfectious inflammatory lesions of the mandible occur in chronic recurrent multifocal osteomyelitis (CRMO). Diffuse sclerosing osteomyelitis of the mandible (DSOM) is a condition thought to be a localized form of CRMO. Recently, bisphosphonate therapy, and particularly intravenous pamidronate, has been proposed as a treatment for patients with both CRMO and DSOM who do not improve with nonsteroidal antiinflammatory drug treatment. We report our experience using pamidronate in 2 children with chronic noninfectious osteomyelitis affecting the mandible. We describe the clinical and radiographic features and the treatment, side effects, and clinical and radiographic responses. Our experience suggests that pamidronate is an effective second-line therapy.
authors.affiliation: Division of Rheumatology, Departments of Paediatrics and Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Compeyrot-Lacassagne
authors.forename: Alan M
authors.initials: AM
authors.lastname: Rosenberg
authors.forename: Paul
authors.initials: P
authors.lastname: Babyn
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Laxer
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008334:Mandible / Q000473:pathology*; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D010015:Osteolysis, Essential / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D000077268:Pamidronate; D012008:Recurrence; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D000077268:Pamidronate