Cystatin C as a risk factor for outcomes in chronic kidney disease.
BACKGROUND
No study has compared cystatin C level, serum creatinine concentration, and estimated glomerular filtration rate (GFR) as risk factors for outcomes in chronic kidney disease (CKD), and none has compared measured GFR with CKD in any population.


OBJECTIVE
To compare cystatin C level with serum creatinine concentration and iothalamate GFR as risk factors for death and kidney failure.


METHODS
Observational study using serum cystatin C assayed from baseline samples of the Modification of Diet in Renal Disease Study (1989-1993).


METHODS
15 clinical centers in the United States that participated in the Modification of Diet in Renal Disease Study.


METHODS
825 trial participants with stage 3 or 4 nondiabetic CKD who had measurements of serum cystatin C.


METHODS
All-cause mortality, cardiovascular (CVD) mortality, and kidney failure until December 2000.


RESULTS
Mean cystatin C level, creatinine concentration, and GFR were 2.2 mg/L (SD, 0.7), 212.16 micromol/L (SD, 88.4) (2.4 mg/dL [SD, 1.0]), and 33 mL/min per 1.73 m2 (SD, 12), respectively. Median follow-up was 10 years. Twenty-five percent of patients (n = 203) died of any cause, 15% (n = 123) died of CVD, and 66% (n = 548) reached kidney failure. In multivariate-adjusted models, 1-SD decreases in 1/creatinine, GFR, and 1/cystatin C were associated with increased risks for all-cause mortality of 1.27 (95% CI, 1.06 to 1.49), 1.27 (CI, 1.08 to 1.49), and 1.41 (CI, 1.18 to 1.67), respectively. For CVD mortality, the increased risks were 1.32 (CI, 1.05 to 1.64), 1.28 (CI, 1.04 to 1.59), and 1.64 (CI, 1.28 to 2.08), respectively. For kidney failure, the increased risks were 2.81 (CI, 2.48 to 3.18), 2.41 (CI, 2.15 to 2.70), and 2.36 (CI, 2.10 to 2.66), respectively.


CONCLUSIONS
The Modification of Diet in Renal Disease Study cohort may not be representative of all patients with nondiabetic CKD because participants were more likely to reach kidney failure than death in follow-up.


CONCLUSIONS
The association of cystatin C level with all-cause and CVD mortality was as strong as or perhaps stronger than that of iothalamate GFR with these outcomes in stage 3 or 4 CKD.
Menon
Vandana
V
Tufts-New England Medical Center, Boston, Massachusetts 02111, USA.
Shlipak
Michael G
MG
Wang
Xuelei
X
Coresh
Josef
J
Greene
Tom
T
Stevens
Lesley
L
Kusek
John W
JW
Beck
Gerald J
GJ
Collins
Allan J
AJ
Levey
Andrew S
AS
Sarnak
Mark J
MJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000401:mortality*; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D008875:Middle Aged; D009026:Mortality; D051437:Renal Insufficiency / Q000209:etiology*; D012307:Risk Factors; D012680:Sensitivity and Specificity
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine