title: Effects of sulodexide on hemostatic factors, lipid profile, and inflammation in chronic peritoneal dialysis patients.
abstract: Sulodexide, a standardized extractive glycosaminoglycan containing 80% "fast moving" heparin and 20% dermatan sulfate, decreased plasma D-dimer, a marker of intravascular coagulation, and fibrinogen levels in chronic peritoneal dialysis patients. Blood levels of von Willebrand factor, lipid, and high-sensitivity C-reactive protein were not significantly changed. No bleeding episodes were reported. These results suggest that sulodexide was effective in partially reversing the thrombogenic coagulation profile without increasing the risk of bleeding.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sbkin@amc.seoul.kr
authors.forename: Soon Bae
authors.initials: SB
authors.lastname: Kim
authors.forename: Su Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Moo Song
authors.initials: MS
authors.lastname: Lee
authors.forename: Jai Won
authors.initials: JW
authors.lastname: Chang
authors.forename: Sang Koo
authors.initials: SK
authors.lastname: Lee
authors.forename: Jung Sik
authors.initials: JS
authors.lastname: Park
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D011446:Prospective Studies; D016896:Treatment Outcome; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D000925:Anticoagulants; D015415:Biomarkers; D006025:Glycosaminoglycans; D008055:Lipids; D014841:von Willebrand Factor; C007858:glucuronyl glucosamine glycan sulfate; D002097:C-Reactive Protein