title: Three-year duration of immunity in dogs vaccinated with a canarypox-vectored recombinant canine distemper virus vaccine.
abstract: Two studies evaluated the duration of serologic response to the recombinant, canarypox-vectored canine distemper virus vaccine (Recombitek, Merial). Serologic duration of immunity was shown to be at least 36 months. Thus, Recombitek provides protection when administered less frequently than the manufacturer's label. After the initial vaccination protocol of two or more doses administered approximately 4 weeks apart, with the last dose given at 12 to 16 weeks of age or older, and re-vaccination at 1 year of age, Recombitek can confidently be readministered every 3 years with assurance of protection in immunocompetent dogs. This allows the vaccine to be administered in accordance with the recommendations of the American Animal Hospital Association Canine Vaccine Task Force and others.
authors.affiliation: Department of Pathological Sciences, University of Wisconsin-Madison, WI 53706-1102, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Larson
authors.forename: R D
authors.initials: RD
authors.lastname: Schultz
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D018150:Avipoxvirus / Q000276:immunology; D004216:Distemper / Q000517:prevention & control*; D004217:Distemper Virus, Canine / Q000276:immunology*; D004285:Dogs; D005260:Female; D008297:Male; D011993:Recombinant Fusion Proteins / Q000276:immunology; D013997:Time Factors; D014614:Vaccines, Synthetic; D014765:Viral Vaccines
chemical_list: D000914:Antibodies, Viral; D011993:Recombinant Fusion Proteins; D014614:Vaccines, Synthetic; D014765:Viral Vaccines