title: Short and efficient diastereoselective synthesis of pyrrolidinone-containing dipeptide analogues.
abstract: The pyrrolidine-2,4-diones have been identified as a convenient starting point for the synthesis of peptide analogues. Herein we describe an optimized two-step reductive amination procedure, which provides a small library of pyrrolidinone-containing dipeptide analogues in high yield and excellent diastereoselectivity.
authors.affiliation: Department of Chemistry, Technical University of Denmark, Building 201, DK-2800 Kgs. Lyngby, Denmark.
authors.forename: Masood
authors.initials: M
authors.lastname: Hosseini
authors.forename: Jakob S
authors.initials: JS
authors.lastname: Grau
authors.forename: Kasper K
authors.initials: KK
authors.lastname: Sørensen
authors.forename: Inger
authors.initials: I
authors.lastname: Søtofte
authors.forename: David
authors.initials: D
authors.lastname: Tanner
authors.forename: Anthony
authors.initials: A
authors.lastname: Murray
authors.forename: Janne E
authors.initials: JE
authors.lastname: Tønder
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D011760:Pyrrolidinones / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D004151:Dipeptides; D011760:Pyrrolidinones