title: Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.
abstract: Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we genotyped 99,632 SNPs in 1,257 affected individuals and 1,336 controls from Ontario. In stages 2-4, we performed serial replication studies using 4,024 affected individuals and 4,042 controls from Seattle, Newfoundland and Scotland. We identified one locus on chromosome 8q24 and another on 9p24 having combined odds ratios (OR) for stages 1-4 of 1.18 (trend; P = 1.41 x 10(-8)) and 1.14 (trend; P = 1.32 x 10(-5)), respectively. Additional analyses in 2,199 affected individuals and 2,401 controls from France and Europe supported the association at the 8q24 locus (OR = 1.16, trend; 95% confidence interval (c.i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer.
authors.affiliation: Cancer Care Ontario, 620 University Avenue, Toronto, Ontario M5G 1L7, Canada.
authors.forename: Brent W
authors.initials: BW
authors.lastname: Zanke
authors.forename: Celia M T
authors.initials: CM
authors.lastname: Greenwood
authors.forename: Jagadish
authors.initials: J
authors.lastname: Rangrej
authors.forename: Rafal
authors.initials: R
authors.lastname: Kustra
authors.forename: Albert
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authors.lastname: Tenesa
authors.forename: Susan M
authors.initials: SM
authors.lastname: Farrington
authors.forename: James
authors.initials: J
authors.lastname: Prendergast
authors.forename: Sylviane
authors.initials: S
authors.lastname: Olschwang
authors.forename: Theodore
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authors.lastname: Chiang
authors.forename: Edgar
authors.initials: E
authors.lastname: Crowdy
authors.forename: Vincent
authors.initials: V
authors.lastname: Ferretti
authors.forename: Philippe
authors.initials: P
authors.lastname: Laflamme
authors.forename: Saravanan
authors.initials: S
authors.lastname: Sundararajan
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Roumy
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Olivier
authors.forename: Frédérick
authors.initials: F
authors.lastname: Robidoux
authors.forename: Robert
authors.initials: R
authors.lastname: Sladek
authors.forename: Alexandre
authors.initials: A
authors.lastname: Montpetit
authors.forename: Peter
authors.initials: P
authors.lastname: Campbell
authors.forename: Stephane
authors.initials: S
authors.lastname: Bezieau
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: O'Shea
authors.forename: George
authors.initials: G
authors.lastname: Zogopoulos
authors.forename: Michelle
authors.initials: M
authors.lastname: Cotterchio
authors.forename: Polly
authors.initials: P
authors.lastname: Newcomb
authors.forename: John
authors.initials: J
authors.lastname: McLaughlin
authors.forename: Ban
authors.initials: B
authors.lastname: Younghusband
authors.forename: Roger
authors.initials: R
authors.lastname: Green
authors.forename: Jane
authors.initials: J
authors.lastname: Green
authors.forename: Mary E M
authors.initials: ME
authors.lastname: Porteous
authors.forename: Harry
authors.initials: H
authors.lastname: Campbell
authors.forename: Helene
authors.initials: H
authors.lastname: Blanche
authors.forename: Mourad
authors.initials: M
authors.lastname: Sahbatou
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Tubacher
authors.forename: Catherine
authors.initials: C
authors.lastname: Bonaiti-Pellié
authors.forename: Bruno
authors.initials: B
authors.lastname: Buecher
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Sebastien
authors.initials: S
authors.lastname: Kury
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: John
authors.initials: J
authors.lastname: Potter
authors.forename: Gilles
authors.initials: G
authors.lastname: Thomas
authors.forename: Steven
authors.initials: S
authors.lastname: Gallinger
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hudson
authors.forename: Malcolm G
authors.initials: MG
authors.lastname: Dunlop
mesh_terms: D016022:Case-Control Studies; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide