CYP1A2 F21L and F186L polymorphisms in an Italian population sample.
P450 cytochromes (CYPs) enzymes play a major role in variability of drug response and cancer susceptibility. In particular, up to 60-fold interindividual variation has been detected in the activity of CYP1A2, which is involved in the metabolism of caffeine, several drugs and various toxic and carcinogenic compounds. Aim of this study is to assess the frequency of CYP1A2 F21L and F186L polymorphisms (formerly CYP1A2(*)2 and (*)11 alleles), up to now found in Asiatic populations only. These variants were absent in 500 Italian healthy subjects. Therefore it can be suggested that the variation of CYP1A2-dependent metabolism in the Caucasian population is not related to these two CYP1A2 polymorphisms. Thus, this study supports the view that ethnicity is a relevant factor to be carefully considered in pharmacogenetic studies.
Pucci
Laura
L
Department of Endocrinology and Metabolism, Unit of Diabetes and Metabolism, University of Pisa, Italy.
Geppetti
Annalisa
A
Maggini
Valentina
V
Lucchesi
Daniela
D
Maria Rossi
Anna
A
Longo
Vincenzo
V
D000328:Adult; D019943:Amino Acid Substitution; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2