title: Rescue of the streptomycin antibiotic activity by using streptidine as a "decoy acceptor" for the aminoglycoside-inactivating enzyme adenyl transferase.
abstract: The use of streptidine as a "decoy acceptor" allows the antibiotic activity of streptomycin to recover against the Escherichia coli strain overexpressing the aminoglycoside-modifying enzyme 6-O-adenyl transferase.
authors.affiliation: Departamento de Química Orgánica Biológica, Instituto de Química Orgánica General, CSIC, Madrid 28006, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Latorre
authors.forename: Pablo
authors.initials: P
authors.lastname: Peñalver
authors.forename: Julia
authors.initials: J
authors.lastname: Revuelta
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Asensio
authors.forename: Eduardo
authors.initials: E
authors.lastname: García-Junceda
authors.forename: Agatha
authors.initials: A
authors.lastname: Bastida
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006595:Hexosamines / Q000494:pharmacology*; D013307:Streptomycin / Q000494:pharmacology*; D014166:Transferases / Q000378:metabolism*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006146:Guanidines; D006595:Hexosamines; C005733:streptidine; D014166:Transferases; D013307:Streptomycin