title: In vitro hypoglycemic activity of methanolic extract of some indigenous plants.
abstract: Pakistan is rich in medicinally important plants and has ancient herbal treatment methods. Present work is based on the study of six indigenous plants Eugenia jambolana, Lawsonia inermis, Momordica charantia, Morus alba, Nigella sativa and Trigonella foenum graecum which show the inhibitory effect of glucose utilization, and are in use as hypoglycemic agents of varying degree in traditional system of medicine. The glucose uptake activity of (methanolic extracts) of these plants was tested in vitro and glucose was estimated by glucose oxidase method. The results in three different media revealed that, hypoglycemic activity is more prominent in neutral and basic media as compared to acidic medium.
authors.affiliation: Department of Chemistry, University of Karachi, Karachi-75270, Pakistan. msarayne@gmail.com
authors.forename: M Saeed
authors.initials: MS
authors.lastname: Arayne
authors.forename: Najma
authors.initials: N
authors.lastname: Sultana
authors.forename: Agha Zeeshan
authors.initials: AZ
authors.lastname: Mirza
authors.forename: M Hashim
authors.initials: MH
authors.lastname: Zuberi
authors.forename: Farhan Ahmed
authors.initials: FA
authors.lastname: Siddiqui
mesh_terms: D005947:Glucose / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification*; D031564:Lawsonia Plant / Q000737:chemistry; D000432:Methanol; D029777:Momordica charantia / Q000737:chemistry; D031625:Morus / Q000737:chemistry; D031881:Nigella sativa / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000737:chemistry*; D027842:Syzygium / Q000737:chemistry; D029910:Trigonella / Q000737:chemistry
chemical_list: D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005947:Glucose; D000432:Methanol