Soy isoflavone aglycone modulates expression of cell surface antigens in vitro and in vivo.
Soy isoflavone aglycones (IFAs) have a wide range of biological actions. We investigated in this study the effect of IFAs on myeloid cells. The cell surface expression of both CD80 and CD86 was up-regulated by treating myeloid cells with IFAs in vitro and in vivo. The findings suggest that IFAs could modulate the myeloid cell function.
Harada
Toshie
T
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy & Life Science, Hachioji, Tokyo, Japan.
Arii
Masayuki
M
Tsuji
Ryohei F
RF
Adachi
Yoshiyuki
Y
Nakajima
Mitsuhiro
M
Yadomae
Toshiro
T
Ohno
Naohito
N
D000818:Animals; D018122:B7-1 Antigen / Q000096:biosynthesis / Q000235:genetics*; D051940:B7-2 Antigen / Q000096:biosynthesis / Q000235:genetics*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D007529:Isoflavones / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D022423:Myeloid Cells / Q000378:metabolism*; D047071:beta-Glucans
D018122:B7-1 Antigen; D051940:B7-2 Antigen; D007529:Isoflavones; D047071:beta-Glucans; C508230:soy isoflavone aglycone