title: Nuclear mechanics and methods.
abstract: The role of the nucleus in protecting and sequestering the genome is intrinsically mechanical, and disease-causing structural mutants in lamins and other components underscore this function. Various methods to measure nuclear mechanics, isolated or in situ, are outlined here in some detail.
authors.affiliation: Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital,/Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Jan
authors.initials: J
authors.lastname: Lammerding
authors.forename: Kris Noel
authors.initials: KN
authors.lastname: Dahl
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Discher
authors.forename: Roger D
authors.initials: RD
authors.lastname: Kamm
mesh_terms: D001696:Biomechanical Phenomena / Q000379:methods*; D002467:Cell Nucleus / Q000737:chemistry* / Q000648:ultrastructure; D003599:Cytoskeleton / Q000737:chemistry; D012212:Rheology / Q000379:methods