Evaluation of the EIE-IgM-Leptospirose assay for the serodiagnosis of leptospirosis.
Access to low-cost, effective diagnosis for leptospirosis is urgently needed in developing countries. The EIE-IgM-Leptospirose, a kit produced for public health laboratories in Brazil, was shown to have a sensitivity of 76% (77 of 102 patients) and 100% (102 of 102 patients) during acute and convalescent-phase leptospirosis, respectively, and a specificity of 93-100% (total healthy and patient control subjects evaluated, 486). These findings indicate that the assay will be useful for diagnosis of this emerging infectious disease in Brazil and other developing countries.
McBride
Alan J A
AJ
Gonçalo Moniz Research Centre, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Brazil.
Pereira
Fernanda A
FA
da Silva
Emilson D
ED
de Matos
Rosan B
RB
da Silva
Edimilson D
ED
Ferreira
Antônio G P
AG
Reis
Mitermayer G
MG
Ko
Albert I
AI
D001938:Brazil / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D007922:Leptospirosis / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology*; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D012698:Serologic Tests
D007075:Immunoglobulin M; D011933:Reagent Kits, Diagnostic