Selection and analysis of solid-binding peptides.
Nature has long used peptide- and protein-based manufacturing to create structures whose remarkable mechanical, transport, optical, and even magnetic properties are determined by a fine control of composition and architecture extending from the nanoscale to the macroscale. Although there is much to learn from the tools and strategies that have been evolutionary selected for building biomaterials, accessing compositions and architectures of engineering interest is crucial to the development of the next generation of hybrid functional materials. In recent years, portable amino acid sequences selected from combinatorial libraries and supporting the assembly, nucleation, and geometrical organization of solid phases have emerged as attractive tools for bionanofabrication. Here, we review how these polypeptides are selected and progress in the understanding of their interaction with inorganic and synthetic materials.
Baneyx
François
F
Department of Chemical Engineering, University of Washington, Box 351750, Seattle, WA 98195-1750, USA. baneyx@u.washington.edu
Schwartz
Daniel T
DT
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D036103:Nanotechnology / Q000379:methods; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D019151:Peptide Library; D010455:Peptides