Mechanism of adaptation of the vascular system to chronic changes in nitric oxide level in the organism.
We studied the possibility of directed modulation of the efficiency of NO storage in rats due to adaptation to the chronic changes in plasma NO level. The efficiency of NO storage increased during long-term maintenance of high plasma level of NO and decreased in NO-deficient states. The compensatory changes in NO storage capacity of vessels depending on its organism content represent a new mechanism of adaptation of the cardiovascular system to chronic excess or deficit of NO, while directed modulation of this process can be important for the protection of the organism against both surplus or shortage of NO.
Vlasova
M A
MA
State Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences; Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Smirin
B V
BV
Pokidyshev
D A
DA
Mashina
S Yu
SY
Vanin
A F
AF
Malyshev
I Yu
IY
Manukhina
E B
EB
D000222:Adaptation, Physiological; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D001158:Arteries / Q000378:metabolism; D002319:Cardiovascular System / Q000378:metabolism*; D002614:Chelating Agents / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007501:Iron / Q000378:metabolism; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000097:blood / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000378:metabolism; D009589:Nitrogen Oxides / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D002614:Chelating Agents; D004791:Enzyme Inhibitors; D020030:Nitric Oxide Donors; D009589:Nitrogen Oxides; D014662:Vasoconstrictor Agents; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D004050:Ditiocarb; D007501:Iron; D019331:NG-Nitroarginine Methyl Ester; D009638:Norepinephrine