[Homocystein serum levels and lipid parameters in children with atherosclerosis risk factors].
Atherosclerosis is a disease of adult patients, however, it begins in childhood and progresses from fatty streaks to raised lesions in arteries in adolescence and young adults. Clinical manifestation of atherosclerosis in adulthood depends on the risk factors such as: lipid disorders, obesity, hypertension, smoking habits and family history of CHD. High serum homocysteine concentration is increasingly recognised as a new risk factor for atherosclerosis and other vascular diseases. Atherogenic effect of homocystein is related to cytotoxin action on the endothelial cells and their function. The aim of this study was to estimate relations between the homocysteine serum concentration and the lipid levels in children with atherosclerosis risk factors.


METHODS
The study was carried out on 48 children with atherosclerosis risk factors. The control group consisted of 25 healthy childrens. Total cholesterol (TC), Triglycerides (TG), HDL-C, LDL-C were determined by enzymatic method. Concentration of homocysteine was estimated by immunoenzymatic method (ELISA).


RESULTS
Obesity, lipid disorders, and hypertension were the most frequent risk factors in the investigated children. Statistically significant higher concentration of TC, LDL-C, TG and lower HDL-C were observed in children with atherosclerosis risk factors. No significant differences in homocystein concentration were observed in the investigated groups, but homocystein concentration was significantly higher in group of children with atherosclerosis risk factors.


CONCLUSIONS
We observed that increased number of the risk factors is followed by high homocystein concentration in the serum.
Sierakowska-Fijałek
Anna
A
Uniwersytet Medyczny w Lodzi, Zakład Patofizjologii i Immunologii Klinicznej. annasierakowska@poczta.onet.pl
Kaczmarek
Piotr
P
Pokoca
Lech
L
Smorag
Ireneusz
I
Wosik-Erenbek
Marzenna
M
Baj
Zbigniew
Z
D000293:Adolescent; D050197:Atherosclerosis / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D015897:Comorbidity; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D052439:Lipid Metabolism Disorders / Q000097:blood* / Q000453:epidemiology; D008074:Lipoproteins / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D014280:Triglycerides; D006710:Homocysteine