title: Sinus floor elevation using autogenous bone or bone substitute combined with platelet-rich plasma.
abstract: OBJECTIVE
  Sinus augmentation is a common approach for patients with severe alveolar ridge atrophy. However, autogenous bone sometimes results in donor site complications. Bone substitutes with platelet-rich plasma (PRP) promote early bone formation with autogenous bone. Use of PRP on autogenous bone and a bovine bone substitute were investigated in this split-mouth animal study.
  
  
  METHODS
  Premolars were extracted from minipigs. Each animal received sinus augmentation using a lateral approach with simultaneous insertion of 3 implants in each site. Groups were randomized using autogenous bone alone and combined with PRP or a bovine hydroxyapatite alone in combination with PRP.
  
  
  RESULTS
  Microradiographic findings in the autogenous group did not show significantly different rates by using autogenous bone alone or combined with PRP. Using the bovine hydroxyapatite as augmentation material only at 8 weeks, a nonsignificant effect in the PRP group could be seen. At all other observation periods, no significant influence was observed.
  
  
  CONCLUSIONS
  No significant influence of PRP was found.
authors.affiliation: Department of Oral Maxillofacial Surgery, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany. andreas.schlegel@yahoo.de
authors.forename: Karl Andreas
authors.initials: KA
authors.lastname: Schlegel
authors.forename: Robert
authors.initials: R
authors.lastname: Zimmermann
authors.forename: Michael
authors.initials: M
authors.lastname: Thorwarth
authors.forename: Friedrich-Wilhelm
authors.initials: FW
authors.lastname: Neukam
authors.forename: Boworn
authors.initials: B
authors.lastname: Klongnoi
authors.forename: Emeka
authors.initials: E
authors.lastname: Nkenke
authors.forename: Endre
authors.initials: E
authors.lastname: Felszeghy
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000000981:diagnostic imaging / Q000379:methods*; D002417:Cattle; D003758:Dental Implantation, Endosseous / Q000379:methods; D017886:Durapatite / Q000627:therapeutic use; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000601:surgery*; D008852:Microradiography / Q000379:methods; D023421:Models, Animal; D053657:Platelet-Rich Plasma / Q000000981:diagnostic imaging*; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D017886:Durapatite