Clinical efficacy of citalopram alone or augmented with bupropion in methadone-stabilized patients.
Despite the success of opiate-agonist therapies such as methadone for the treatment of opiate addiction, treatment response is not complete. This study evaluates the efficacy of citalopram augmented with bupropion in the treatment of illicit opiate use in a methadone-stabilized population. We conducted a 12-week randomized, double-blind, outpatient clinical trial in which 60 subjects were randomized into one of three treatment groups: placebo, citalopram (40 mg/day) plus placebo, or citalopram (40 mg/day) plus bupropion (50 mg/day). The results indicate that neither citalopram nor citalopram augmented with bupropion were more effective than placebo in the treatment of opioid abuse.
Poling
James
J
Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA. james.poling@yale.edu
Pruzinsky
Rhonda
R
Kosten
Thomas R
TR
Gonsai
Kishorchandra
K
Sofuoglu
Mehmet
M
Gonzalez
Gerardo
G
Oliveto
Alison
A
D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000209:etiology; D016642:Bupropion / Q000627:therapeutic use*; D015283:Citalopram / Q000627:therapeutic use*; D019970:Cocaine-Related Disorders / Q000188:drug therapy / Q000523:psychology / Q000652:urine; D003866:Depressive Disorder / Q000209:etiology; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000188:drug therapy* / Q000523:psychology / Q000652:urine; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D000701:Analgesics, Opioid; D016642:Bupropion; D015283:Citalopram; D018765:Dopamine Uptake Inhibitors; D008691:Methadone; D017367:Selective Serotonin Reuptake Inhibitors