Murine models of vascular thrombosis (Eitzman series).
Thrombotic complications of vascular disease are the leading cause of morbidity and mortality in most industrialized countries. Despite this, safe and effective drugs targeting these complications are limited, especially in the chronic setting. This is because of the complexity of thrombosis in both arteries and veins, which is becoming increasingly evident as numerous factors are now known to affect the fate of a forming thrombus. To fully characterize thrombus formation in these settings, in vivo models are necessary to study the various components and intricate interactions that are involved. Genetic manipulations in mice are greatly facilitating the dissection of relevant pro- and antithrombotic influences. Standardized models for the study of thrombosis in mice as well as evolving techniques that allow imaging of molecular events during thrombus formation are now available. This review will highlight some of the recent developments in the field of thrombosis using mouse models and how these studies are expanding our knowledge of thrombotic disease.
Westrick
Randal J
RJ
Departments of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. westricr@umich.edu
Winn
Mary E
ME
Eitzman
Daniel T
DT
D000818:Animals; D050197:Atherosclerosis / Q000235:genetics; D001777:Blood Coagulation; D001808:Blood Vessels / Q000293:injuries / Q000503:physiopathology; D002712:Chlorides; D003094:Collagen / Q000633:toxicity; D004195:Disease Models, Animal; D004837:Epinephrine / Q000633:toxicity; D005290:Ferric Compounds / Q000633:toxicity; D005838:Genotype; D007834:Lasers / Q000009:adverse effects; D051379:Mice; D008822:Mice, Transgenic; D008856:Microscopy, Fluorescence; D018715:Microscopy, Video; D010641:Phenotype; D015203:Reproducibility of Results; D012395:Rose Bengal / Q000633:toxicity; D013045:Species Specificity; D013927:Thrombosis / Q000097:blood / Q000139:chemically induced / Q000209:etiology / Q000235:genetics / Q000503:physiopathology
D002712:Chlorides; D005290:Ferric Compounds; D012395:Rose Bengal; D003094:Collagen; C024555:ferric chloride; D004837:Epinephrine