The X factor: skewing X inactivation towards cancer.
Increased expression of the epidermal growth factor receptor HER-2/ErbB2 is frequently observed in breast cancer and is targeted by the anticancer drug Herceptin. Now, Zuo et al. (2007) reveal that an X-linked gene encoding the transcription factor FOXP3 is a breast cancer tumor suppressor that represses expression of HER2/ErbB2.
Medema
René H
RH
Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, Stratenum, 3584CG Utrecht, The Netherlands. r.h.medema@umcutrecht.nl
Burgering
Boudewijn M Th
BM
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D051858:Forkhead Transcription Factors / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D049951:X Chromosome Inactivation / Q000235:genetics*
D051858:Forkhead Transcription Factors; D018719:Erb-b2 Receptor Tyrosine Kinases; D025521:Tumor Suppressor Proteins; C418974:FOXP3 protein, human