[Absolute risk for fracture and WHO guideline. Biological markers for osteoarthritis (OA)].
Biological markers for osteoarthritis (OA) are indicators of articular tissue metabolism, measuring the levels of molecules derived from joint structures into synovial fluids, serum and urine. Radiological findings are the basis of diagnosis of OA, but have a weakpoint visualizing the figures that have already occurred. For assessing disease activity or monitoring disease progression, estimation of articular metabolism using biological markers is very important. Synovial fluid reflects specifically the status of the punctured joint, however invasive. Less-invasive newly developed serum and urine markers appear to be also useful for the evaluation of OA.
Date
Hideki
H
Fujita Health University, Department of Orthopaedic Surgery.
Yamada
Harumoto
H
Kanaji
Arihiko
A
Tajima
Kaori
K
Hayakawa
Kazue
K
Maehara
Kazuyuki
K
Miyazaki
Kyosuke
K
Masuda
Hiroyuki
H
D015415:Biomarkers / Q000097:blood / Q000652:urine; D064236:Cartilage Oligomeric Matrix Protein; D024043:Collagen Type II / Q000652:urine*; D016326:Extracellular Matrix Proteins / Q000097:blood*; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D064235:Matrilin Proteins; D010003:Osteoarthritis / Q000175:diagnosis*
D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D024043:Collagen Type II; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; C577553:TSP5 protein, human; D006820:Hyaluronic Acid