Structure and biology of self lipid antigens.
Self lipid antigens induce selection and expansion of autoreactive T cells which have a role in immunoregulation and disease pathogenesis. Here we review the important biological rules which determine lipid immunogenicity. The impact of lipid structure, synthesis, traffic, membrane distribution and CD1 loading are discussed.
De Libero
G
G
Department of Research, University Hospital, Basel, Switzerland. gennaro.delibero@unibas.ch
Mori
L
L
D000818:Animals; D018949:Antigens, CD1 / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D006017:Glycolipids / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D020275:Guillain-Barre Syndrome / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D050356:Lipid Metabolism; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology / Q000503:physiopathology; D013601:T-Lymphocytes / Q000276:immunology
D018949:Antigens, CD1; D006017:Glycolipids