title: Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer.
abstract: BACKGROUND
  Gastric cancer is the second highest cause of cancer mortality in the world, despite declining rates of incidence in many industrialized countries. We carried out a case-control study to evaluate whether polymorphisms of DNA repair and glutathione S-transferase (GST) genes modulate the risk of developing diffuse gastric cancer.
  
  
  METHODS
  ERCC1 118 T/C, XRCC1 399 G/A, XPD 312 G/A, XPD 751 A/C, XRCC3 241 C/T, MS 919 A/G, GSTP1 105 A/G, GSTM1-null/positive and GSTT1-null/positive genotypes were obtained for a series of 126 Helicobacter pylori-negative diffuse gastric cancer patients and 144 Helicobacter pylori-negative controls sampled from the population of Marche, an area with high gastric cancer risk in central Italy.
  
  
  RESULTS
  GSTP1 105 A/G and GSTP1 105 G/G genotypes were identified as protective factors, with odds ratio (OR) of 0.4 (95% CI 0.17-0.81, p=0.01) and OR=0.58 (95% CI 0.33-1, p=0.05), respectively. GSTT1-null genotype was identified as a protective factor, with OR=0.48 (95% CI 0.22-0.99, p=0.04). There was no significant difference between cases and controls for XPD 751 A/C, ERCC1 118 T/C, XRCC3 241 C/T, XRCC1 399 G/A, XPD 312 G/A, GSTM1-null/positive and MS 919 A/G polymorphisms.
  
  
  CONCLUSIONS
  This study suggests that GSTP1 105A/G and GSTT1-null/positive genotypes might be associated with a reduced risk for sporadic diffuse gastric cancer. Clin Chem Lab Med 2007;45:822-8.
authors.affiliation: Institute of Biochemistry G. Fornaini, University of Urbino, Urbino, Italy. ruzzoa@uniurb.it
authors.forename: Annamaria
authors.initials: A
authors.lastname: Ruzzo
authors.forename: Emanuele
authors.initials: E
authors.lastname: Canestrari
authors.forename: Paolo
authors.initials: P
authors.lastname: Maltese
authors.forename: Francesca
authors.initials: F
authors.lastname: Pizzagalli
authors.forename: Francesco
authors.initials: F
authors.lastname: Graziano
authors.forename: Daniele
authors.initials: D
authors.lastname: Santini
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Catalano
authors.forename: Rita
authors.initials: R
authors.lastname: Ficarelli
authors.forename: Davide
authors.initials: D
authors.lastname: Mari
authors.forename: Renato
authors.initials: R
authors.lastname: Bisonni
authors.forename: Paolo
authors.initials: P
authors.lastname: Giordani
authors.forename: Lucio
authors.initials: L
authors.lastname: Giustini
authors.forename: Paolo
authors.initials: P
authors.lastname: Lippe
authors.forename: Rosarita
authors.initials: R
authors.lastname: Silva
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Mattioli
authors.forename: Umberto
authors.initials: U
authors.lastname: Torresi
authors.forename: Luciano
authors.initials: L
authors.lastname: Latini
authors.forename: Mauro
authors.initials: M
authors.lastname: Magnani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism*; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D015262:Xenobiotics