Effect of nitroglycerin on some parameters of the prooxidant-antioxidant balance and functional state of the liver during ischemia/reperfusion.
The effect of nitroglycerine on some parameters of the prooxidant-antioxidant balance and functional state of the liver under conditions of ischemia/reperfusion was studied on rabbits. Hepatic ischemia/reperfusion was accompanied by accumulation of LPO products, depletion of the antioxidant defense system, and increase in blood transaminase activity. Nitroglycerine infusion before the reperfusion period decreased the concentration of LPO products, increased activity of the antioxidant system, and improved liver function.
Khodosovskii
M N
MN
Department of Pathological and Normal Physiology, Grodno State Medical University. hodosovsky@grsmu.by
Zinchuk
V V
VV
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D001219:Aspartate Aminotransferases / Q000097:blood; D007511:Ischemia / Q000150:complications / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000098:blood supply* / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D005996:Nitroglycerin / Q000494:pharmacology*; D011817:Rabbits; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism*; D012545:Schiff Bases / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood
D000975:Antioxidants; D009566:Nitrates; D009573:Nitrites; D012545:Schiff Bases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005996:Nitroglycerin; D024502:alpha-Tocopherol