title: Enantioselective spirocyclizations from tryptophanol-derived oxazolopiperidone lactams.
abstract: A straightforward synthetic route to enantiopure spiro[indole-3,3'-indolizidines] is reported. The key step is a Lewis acid promoted cyclization of a Na-tosyltryptophanol-derived oxazolopiperidone lactam in the presence of Et3SiH.
authors.affiliation: Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Amat
authors.forename: Maria M M
authors.initials: MM
authors.lastname: Santos
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Gómez
authors.forename: Danica
authors.initials: D
authors.lastname: Jokic
authors.forename: Elies
authors.initials: E
authors.lastname: Molins
authors.forename: Joan
authors.initials: J
authors.lastname: Bosch
mesh_terms: D003500:Cyclization; D007769:Lactams / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D010881:Piperidones / Q000737:chemistry*; D014364:Tryptophan / Q000737:chemistry*
chemical_list: D007769:Lactams; D010080:Oxazoles; D010881:Piperidones; D014364:Tryptophan