A single bout of brisk walking increases basal very low-density lipoprotein triacylglycerol clearance in young men.
Very low-density lipoprotein triacylglycerol (VLDL-TG) turnover rate was evaluated in the morning, 12 hours after a single bout of brisk walking (90 minutes at approximately 60% of VO2max; EXE), compared to a resting control period (CON) in 10 recreationally active men. VLDL-TG fractional catabolic rate was calculated from the decay in isotopic enrichment after a bolus injection of [2H5]glycerol. Plasma VLDL-TG concentration was 24% lower in the morning after the EXE trial compared to control (0.47+/-0.04 and 0.36+/-0.04 mmol L(-1), for CON and EXE, respectively; P<.01). Serum insulin (7.4+/-0.7 and 5.6+/-0.4 mIU L(-1), CON and EXE, respectively; P<.05) and plasma glucose (5.6+/-0.1 and 5.4+/-0.1 mmol/L, CON and EXE, respectively; P<.05) concentrations were also significantly lower in the EXE trial. Insulin sensitivity (homeostasis model assessment [HOMA] index) was improved by 27% in EXE compared with the CON trial (P<.05).VLDL-apolipoprotein B-100 and plasma fatty acid concentrations were similar in the two trials. Hepatic VLDL-TG secretion rates were not significantly affected by exercise (13.1+/-1.2 and 13.2+/-1.6 micromol.min(-1) for the CON and EXE trials, respectively), whereas VLDL-TG clearance rate increased by 36% (28.1+/-1.3 and 38.1+/-3.5 mL.min(-1) for the CON and EXE trials, respectively; P<.05). It is concluded that the decrease in fasting plasma VLDL-TG concentration observed 12 hours after brisk walking is related mainly to increased VLDL-TG clearance from plasma.
Tsekouras
Yiannis E
YE
Department of Nutrition and Dietetics, Laboratory of Nutrition and Clinical Dietetics, Harokopio University, 176-71 Athens, Greece.
Yiannis
Tsekouras E
TE
Yanni
Amalia E
AE
Amalia
Yanni E
YE
Bougatsas
Dimitrios
D
Dimitrios
Bougatsas
B
Kavouras
Stavros A
SA
Stavros
Kavouras A
KA
Sidossis
Labros S
LS
Labros
Sidossis S
SS
D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology; D001823:Body Composition / Q000502:physiology; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D004032:Diet; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D014280:Triglycerides / Q000378:metabolism*; D016138:Walking / Q000502:physiology*
D008079:Lipoproteins, VLDL; D014280:Triglycerides