title: [Clinical study of 34 patients with extranodal NK/T cell lymphoma-nasal type].
abstract: OBJECTIVE
  To explore the clinical feature, the reason of misdiagnosis and mistreatment, influential factor of prognosis in patients with extranodal NK/T cell lymphoma-nasal type.
  
  
  METHODS
  A retrospective study was made on the clinical data of 34 patients with extranodal NK/T cell lymphoma-nasal type. Among them, 10 cases were staged I(E) intra-cavity, 15 cases were I(E) ex-cavity, 6 cases were II(E) and 3 cases were IV(E). Among them, 29 cases were in nasal cavity, 5 cases were outside nasal cavity; 14 cases were treated with single chemotherapy or radiation therapy, 20 cases were treated with radiation therapy add chemotherapy.
  
  
  RESULTS
  The total rate of misdiagnosis and mistreatment were 58.8% (20/34), 52.3% (18/34), respectively. The 5-year survival rate of the I(E) intra-cavity group were 60.0% (6/10), and those of I(E) ex-cavity group were 26.7% (4/15), and those of II(E) group and IV(E) group were 16.7% (1/6), 0% (0/3), respectively There was significant difference between 3 groups by statistical analysis (P < 0.01). The 5-year survival rate of I(E) ex-cavity group treated with single therapy were 0% (0/6), and those of I(E)-cavity group treated with combined therapy were 50% (1/2).
  
  
  CONCLUSIONS
  The early clinical manifestation of extranodal NK/T tell lymphoma-nasal type is atypical and which is hard to diagnose and treat. Diagnosis depends on pathologic biopsy and immunohistochemistry, there are many factors that influence the prognosis of this disease, in which the clinical stage is a major factor. It is crucial for diagnosing and treating early.
authors.affiliation: Department of Eye Ear Nose and Throat, Guangyuan People's Hospital, Guangyuan, 628000, China. gjklw990915@163.com
authors.forename: Xianling
authors.initials: X
authors.lastname: Ren
authors.forename: Quanfan
authors.initials: Q
authors.lastname: Jia
authors.forename: Guangming
authors.initials: G
authors.lastname: Xiang
authors.forename: Zeyu
authors.initials: Z
authors.lastname: Zhao
authors.forename: Kailun
authors.initials: K
authors.lastname: Xu
authors.forename: Wen
authors.initials: W
authors.lastname: Du
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000175:diagnosis / Q000628:therapy; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult