Mechanisms of serotonergic agents for treatment of gastrointestinal motility and functional bowel disorders.
Most of the body's serotonin is released in the gut where it plays an important role in the control of gastrointestinal (GI) motility, sensitivity and muscle tone by activating different receptor subtypes. This review focuses on the known effects of selective serotonin reuptake inhibitor and serotonin receptor agonists and antagonists on the sensorimotor function of the GI tract and describes the therapeutic potential of these actions for GI motility and functional bowel disorders.
Kindt
S
S
Center of Gastroenterological Research, Catholic University Leuven, Leuven, Belgium.
Tack
J
J
D003109:Colonic Diseases, Functional / Q000188:drug therapy*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D018490:Serotonin Agents / Q000494:pharmacology / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000378:metabolism / Q000627:therapeutic use; D017366:Serotonin Receptor Agonists / Q000378:metabolism / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use
D011985:Receptors, Serotonin; D012701:Serotonin; D018490:Serotonin Agents; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors