title: Mist delivery of eye medication to the anterior segment.
abstract: OBJECTIVE
  To compare the mydriatic efficacies of mist and drop delivery of tropicamide 1.0%.
  
  
  METHODS
  Randomized, masked, active, controlled clinical trial.
  
  
  METHODS
  One hundred subjects were randomized to receive small-volume (6 microl) mist administration of tropicamide 1.0% in one eye and either nothing or a conventional drop (30 microl) of the same solution in the fellow eye.
  
  
  RESULTS
  Comparing misted eyes with untreated eyes in the same subjects, the mean maximal increase in pupil diameter in the misted eyes was 2.02 mm and was 0.25 mm in the fellow eyes. The difference is statistically significant (P <or= .001) Comparing mist-treated eyes with drop-treated eyes in the same subjects, the mean maximal increase in pupil diameter in the misted eyes was 1.98 mm and was 2.11 mm in the drop-treated eyes. The difference was not statistically significant (P = .051).
  
  
  CONCLUSIONS
  Small-volume mist and conventional drop delivery of tropicamide 1.0% were shown to be similar in mydriatic effectiveness.
authors.affiliation: Stony Brook University School of Medicine, Stony Brook, New York, USA. optimystsystem@gmail.com
authors.forename: James F
authors.initials: JF
authors.lastname: Collins
authors.forename: Darlene A
authors.initials: DA
authors.lastname: Dartt
authors.forename: Reza
authors.initials: R
authors.lastname: Dana
mesh_terms: D000869:Anterior Eye Segment / Q000187:drug effects*; D004311:Double-Blind Method; D016503:Drug Delivery Systems; D005240:Feasibility Studies; D006801:Humans; D009184:Mydriatics / Q000008:administration & dosage*; D009330:Nebulizers and Vaporizers; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011680:Pupil / Q000187:drug effects*; D014331:Tropicamide / Q000008:administration & dosage*
chemical_list: D009184:Mydriatics; D009883:Ophthalmic Solutions; D014331:Tropicamide