Lack of shedding of the RIX4414 live attenuated rotavirus vaccine administered to adult volunteers.
Ten adult volunteers were given the RIX4414 rotavirus vaccine; one volunteer shed a small amount of virus antigen but not live virus. This suggests that parents of vaccinated children are unlikely to spread the vaccine.
Zibrik
L
L
Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool, UK.
Dove
W
W
McArdle
F
F
Rustom
R
R
Hart
C A
CA
Jackson
M J
MJ
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D002460:Cell Line; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000821:virology; D005260:Female; D005814:Genes, Viral; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D012401:Rotavirus / Q000276:immunology* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000097:blood / Q000276:immunology* / Q000517:prevention & control*; D022243:Rotavirus Vaccines; D013997:Time Factors; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage* / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C492457:RIX4414 vaccine; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated