title: Degradable cisplatin-releasing core-shell nanogels from zwitterionic poly(beta -aminoester)-graft-PEG for cancer chemotherapy.
abstract: Cisplatin conjugated onto macromolecules or loaded in micelles can be preferentially delivered to tumors to minimize its toxicity to healthy tissues and increase its drug efficacy. Herein, we report cisplatin-containing nanogels possibly useful for targeted delivery of cisplatin. Carboxylic acid-functionalized poly(beta -aminoester)graft-poly(ethylene glycol) copolymers were synthesized by cocondensation polymerization of piperazine with 2,2-bis(acryloxymethyl)propionic acid, PEG 2,2-bis(acryloxymethyl)propionate macromonomer (mPEG). The graft copolymers formed 100-200 nm nanogels with low size-distribution by the complexation of their carboxylic groups with cisplatin. The nanogels were negatively charged and had a PEG outer layer. Thus, they had "stealth properties" suitable for in vivo applications. The nanogels had significantly lower in vitro cytotoxicity to SKOV-3 ovarian cancer cells than free cisplatin, but similar anticancer activity toward SKOV-3 tumors xenografted to immunocompromised mice.
authors.affiliation: Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, Wyoming, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Jin
authors.forename: Peisheng
authors.initials: P
authors.lastname: Xu
authors.forename: Yihong
authors.initials: Y
authors.lastname: Zhan
authors.forename: Youqing
authors.initials: Y
authors.lastname: Shen
authors.forename: Edward A
authors.initials: EA
authors.lastname: Van Kirk
authors.forename: Brenda
authors.initials: B
authors.lastname: Alexander
authors.forename: William J
authors.initials: WJ
authors.lastname: Murdoch
authors.forename: Lijian
authors.initials: L
authors.lastname: Liu
authors.forename: Dale D
authors.initials: DD
authors.lastname: Isaak
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use; D002264:Carboxylic Acids / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004952:Esters / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008956:Models, Chemical; D015394:Molecular Structure; D000080385:Nanogels; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010316:Particle Size; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011094:Polyethyleneimine / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013997:Time Factors; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D002264:Carboxylic Acids; D004952:Esters; D000080385:Nanogels; D011108:Polymers; C507253:poly(beta-amino ester); C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine; D002945:Cisplatin