title: Associations between comorbidities, treatment choice and outcome in the elderly with end-stage renal disease.
abstract: BACKGROUND
  New patients treated for end-stage renal disease are increasingly elderly: in France, 38% are 75 years or older. The best treatment choices for the elderly are still debated.
  
  
  METHODS
  We studied case-mix factors associated with choice of initial dialysis modality and 2-year survival in the 3512 patients aged 75 years or older who started dialysis between 2002 and 2005 and were included in the French REIN registry.
  
  
  RESULTS
  Overall, 18% began with peritoneal dialysis (PD), 50% with planned haemodialysis (planned HD) and 32% with unplanned HD, that is, HD that started on an emergency basis. At least one comorbid condition was reported for 85%, and three or more for 36%, but case-mix varied with age. PD was chosen significantly more often than planned HD for the oldest (> or =85) compared with the youngest (75-79) patients: odds ratio 2.1 (95% confidence interval, 1.5-2.8), in those with congestive heart failure: 1.8 (1.5-2.3) and severe behavioural disorder: 2.2 (1.3-3.5), but less often for obese patients: 0.5 (0.3-0.8) and smokers: 0.4 (0.2-0.9). Two-year survival rates were 58, 52 and 39% in patients aged 75-79, 80-84 and > or =85, respectively. Compared with planned HD, unplanned HD was associated with a risk of mortality 50% higher, and PD with a risk 30% higher, independent of patient case-mix.
  
  
  CONCLUSIONS
  PD is a common treatment option in French elderly patients, but our study suggests the need for caution in the long-term use. The high frequency of unplanned HD would require further attention.
authors.affiliation: REIN Registry, Agence de la biomédecine, La Plaine Saint Denis, France. cecile.couchoud@biomedecine.fr
authors.forename: Cécile
authors.initials: C
authors.lastname: Couchoud
authors.forename: Olivier
authors.initials: O
authors.lastname: Moranne
authors.forename: Luc
authors.initials: L
authors.lastname: Frimat
authors.forename: Michel
authors.initials: M
authors.lastname: Labeeuw
authors.forename: Vincent
authors.initials: V
authors.lastname: Allot
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Stengel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000150:complications / Q000401:mortality; D015897:Comorbidity / Q000639:trends*; D003928:Diabetic Nephropathies / Q000401:mortality; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000401:mortality*; D008297:Male; D016016:Proportional Hazards Models; D012042:Registries; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome