Newly reported roles of thyroid-stimulating hormone and follicle-stimulating hormone in bone remodelling.
Thyroid-stimulating hormone (TSH) and follicle-stimulating hormone (FSH) have both been recently implicated in bone remodelling. Clinical evidence, as well as data from TSH receptor and thyroid hormone receptor knockout mice, suggest that TSH has a direct effect on skeletal homeostasis, although some data are conflicting. Recently, the exogenous administration of TSH has been shown to positively impact bone in oophrectomised rats. These data, along with their potential implications for the treatment of severe osteoporosis, are discussed.
Sendak
Rebecca A
RA
Genzyme Corporation, One Mountain Road, Framingham, MA, 01701, USA, rebecca.sendak@genzyme.com
Sampath
T Kuber
TK
McPherson
John M
JM
D000818:Animals; D015519:Bone Density / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology*; D004195:Disease Models, Animal; D005640:Follicle Stimulating Hormone / Q000502:physiology*; D051379:Mice; D010024:Osteoporosis / Q000503:physiopathology; D051381:Rats; D013972:Thyrotropin / Q000502:physiology*
D005640:Follicle Stimulating Hormone; D013972:Thyrotropin