C. elegans aging: proteolysis cuts both ways.
Recent reports from two laboratories working on the nematode Caenorhabditis elegans have identified both positive and negative roles for ubiquitin-mediated proteolysis in the regulation of longevity by the insulin/insulin-like growth factor signaling pathway.
Bowerman
Bruce
B
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA. bbowerman@molbio.uoregon.edu
D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism / Q000502:physiology*; D007328:Insulin / Q000502:physiology*; D008136:Longevity / Q000502:physiology*; D010447:Peptide Hydrolases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013002:Somatomedins / Q000502:physiology*; D025801:Ubiquitin / Q000502:physiology*
D007328:Insulin; D011506:Proteins; D013002:Somatomedins; D025801:Ubiquitin; D010447:Peptide Hydrolases