title: Notch signaling in vascular development and physiology.
abstract: Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles during vascular development and physiology in vertebrates. These roles include regulation of artery/vein differentiation in endothelial and vascular smooth muscle cells, regulation of blood vessel sprouting and branching during both normal development and tumor angiogenesis, and the differentiation and physiological responses of vascular smooth muscle cells. Defects in Notch signaling also cause inherited vascular and cardiovascular diseases. In this review, I summarize recent findings and discuss the growing relevance of Notch pathway modulation for therapeutic applications in disease.
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. tom.gridley@jax.org
authors.forename: Thomas
authors.initials: T
authors.lastname: Gridley
mesh_terms: D000818:Animals; D001158:Arteries / Q000166:cytology / Q000196:embryology; D001808:Blood Vessels / Q000196:embryology* / Q000502:physiology*; D046589:CADASIL / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000235:genetics; D002454:Cell Differentiation; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000502:physiology; D009383:Neoplasms, Vascular Tissue / Q000209:etiology; D009389:Neovascularization, Pathologic / Q000209:etiology; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D014680:Veins / Q000166:cytology / Q000196:embryology
chemical_list: D051880:Receptors, Notch