5-Fluorouracil cardiotoxicity complicating treatment of stage IIB cervical cancer--case report.
A 31-year-old female was found to have FIGO Stage IIB squamous cell carcinoma of the cervix. The patient began her prescribed radiation therapy and 5-fluorouracil radio-sensitizing chemotherapy. During the first day of infusion, she began having severe shortness of breath. Cardiac evaluation revealed acute congestive heart failure with a cardiac ejection fraction of 19%. Radiation was continued without chemotherapy. Four years later, the patient is alive and well with an ejection fraction of 53%.
Geisler
J P
JP
Indiana Women's Oncology, Division of Gynecol. Oncol. St. Vincent Hospitals, 8301 Harcourt Road, Suite 201 46260 Indianapolis, IN, USA.
Manahan
K J
KJ
Rippy
J K
JK
D000208:Acute Disease; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D002303:Cardiac Output, Low / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil