A microfluidic device based on droplet storage for screening solubility diagrams.
This work describes a new microfluidic device developed for the rapid screening of solubility diagrams. In several parallel channels, hundreds of nanolitre volume droplets of a given solution are first stored with a gradual variation in the solute concentration. Then, the application of a temperature gradient along these channels enables us to read directly and quantitatively phase diagrams, concentration vs. temperature. We show, using a solution of adipic acid, that we can measure ten points of the solubility curve in less than 1 hr and with only 250 microL of solution.
Laval
Philippe
P
LOF, unité mixte Rhodia-CNRS-Bordeaux 1, 178 avenue du Docteur Schweitzer, F-33608 Pessac cedex, France. philippe.laval-exterieur@eu.rhodia.com
Lisai
Nicolas
N
Salmon
Jean-Baptiste
JB
Joanicot
Mathieu
M
D000272:Adipates / Q000737:chemistry; D003460:Crystallization; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D044085:Microfluidics; D010316:Particle Size; D012995:Solubility; D013059:Spectrum Analysis, Raman; D013696:Temperature
D000272:Adipates; C029900:adipic acid