title: Intraductal carcinoma of the prostate gland with transmucosal spread to the seminal vesicle: a lesion distinct from high-grade prostatic intraepithelial neoplasia.
abstract: Intraductal carcinoma of the prostate (IDC-P) gland represents an intraluminal neoplastic proliferation that is distinct from high-grade prostatic intraepithelial neoplasia (HG-PIN) and almost always coexists with large-volume, high-stage, and high-grade invasive carcinoma. We document an unusual presentation of apparently "early" IDC-P without an aggressive invasive element that, despite being confined to the acinar-ductal system, has gained access to the ejaculatory duct and seminal vesicle by transmucosal spread. This finding confirms that IDC-P, in contrast to HG-PIN, is inherently aggressive and has the ability to spread beyond the prostate gland. In this case, the absence of an aggressive invasive element suggests that IDC-P has most likely evolved within the lumens directly from HG-PIN.
authors.affiliation: Uropath Pty Ltd, 41 Hampden Rd, Nedlands, Western Australia 6009, Australia. ronnie@uropath.com.au
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Cohen
authors.forename: Beverly A
authors.initials: BA
authors.lastname: Shannon
authors.forename: Sydney L
authors.initials: SL
authors.lastname: Weinstein
mesh_terms: D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012669:Seminal Vesicles / Q000473:pathology*