title: Late dietary intervention limits benefits of soy protein or flax oil in experimental polycystic kidney disease.
abstract: OBJECTIVE
  Dietary soy protein and flax oil retard kidney disease progression when initiated in the early stages of disease in several experimental models, including the Han:SPRD-cy rat. However, individuals with kidney disease often do not become aware of their condition until injury to the kidney is extensive. The objective of this study was to determine whether initiating these interventions in established disease would alter further progression of renal injury.
  
  
  METHODS
  Two-month-old adult male Han:SPRD-cy rats were given either a flax oil diet (7% flax oil), a soy protein diet (20% soy protein) or a control diet (7% corn oil, 20% casein) for 4 months. Renal disease progression was assessed by examining morphological, immunohistochemical and biochemical parameters.
  
  
  RESULTS
  Compared to controls, there was 21-24% less staining of proliferating cells, 21-24% less oxidative damage and 13-15% less renal inflammation in kidneys from rats given dietary soy protein and flax oil. Renal cystic growth and fibrosis and serum creatinine levels were not altered by these dietary treatments.
  
  
  CONCLUSIONS
  Late intervention with dietary soy protein and flax oil reduces some disease-associated pathologies in established renal disease in Han:SPRD-cy rats. The potential benefits of the antioxidant and anti-inflammatory effects on ultimate renal disease outcome in the long term remains to be determined.
authors.affiliation: Departments of Human Nutritional Sciences, University of Manitoba, Winnipeg, Man., Canada.
authors.forename: Deepa
authors.initials: D
authors.lastname: Sankaran
authors.forename: Neda
authors.initials: N
authors.lastname: Bankovic-Calic
authors.forename: Leah
authors.initials: L
authors.lastname: Cahill
authors.forename: Claudia
authors.initials: C
authors.lastname: Yu-Chen Peng
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Ogborn
authors.forename: Harold M
authors.initials: HM
authors.lastname: Aukema
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004334:Drug Administration Schedule; D007668:Kidney / Q000187:drug effects* / Q000473:pathology*; D008043:Linseed Oil / Q000008:administration & dosage*; D007690:Polycystic Kidney Diseases / Q000178:diet therapy* / Q000473:pathology*; D051381:Rats; D030262:Soybean Proteins / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D030262:Soybean Proteins; D008043:Linseed Oil