[Contemporary molecular-biological methods of cancer diagnosis and monitoring based on the humoral immune response to tumor-associated antigens].
Humoral immune response to tumor-associated antigens in cancer patients can be used as a basis for disease diagnosis and monitoring. Moreover, identification of molecular targets of such response may be used to develop antigen-specific anticancer vaccines. Here, we review the main approaches to identification and study of tumor-associated antigens recognized by serum antibodies. We also focus on the challenges that must be met before serological antigens can be used in clinical cancer diagnostics.
Shebzukhov
Iu V
IuV
Belousov
P V
PV
Khlgatian
S V
SV
Sazykin
A Iu
AIu
Kuprash
D V
DV
Nedospasov
S A
SA
D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology*; D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D008991:Monitoring, Physiologic; D009369:Neoplasms / Q000175:diagnosis* / Q000276:immunology*
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm