Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease.
Recently, a region encompassing the promoter and intron 1 of the paraoxonase 1 gene (PON1) have been associated with the risk of developing Alzheimer's disease (AD) in a large pan-ethnic (Caucasian and African-American) dataset. We attempted to replicate this observation in a large French study of sporadic cases and controls. We confirmed that the proximal promoter and 5' sequence of the PON1 gene may harbor unknown functional variant(s) associated with the risk of developing AD.
Chapuis
Julien
J
INSERM U744, Institut Pasteur de Lille, Université de Lille 2, Lille, France.
Boscher
Maud
M
Bensemain
Faiza
F
Cottel
Dominique
D
Amouyel
Philippe
P
Lambert
Jean-Charles
JC
D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005260:Female; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
D043303:Aryldialkylphosphatase; C468406:PON1 protein, human