title: STOX1 gene in pre-eclampsia and intrauterine growth restriction.
abstract: The STOX1 gene, identified as a candidate gene for pre-eclampsia in Dutch women, is placentally expressed and subject to imprinting with preferential transmission of the maternal allele. In our study, STOX1-Y153H frequencies were similar in 157 women with pre-eclampsia (65%) and in 157 controls (64%) from the general Dutch population. In an isolated Dutch population, a distortion could not be demonstrated in the transmission of STOX1-Y153H variation from heterozygous mothers to offspring in 50 and 56 families with pregnancies complicated by pre-eclampsia or intrauterine growth restriction, respectively. Our findings do not confirm previous suggestions that STOX1 plays a major role in Dutch women with pre-eclampsia.
authors.affiliation: Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
authors.forename: A L
authors.initials: AL
authors.lastname: Berends
authors.forename: A M
authors.initials: AM
authors.lastname: Bertoli-Avella
authors.forename: C J M
authors.initials: CJ
authors.lastname: de Groot
authors.forename: C M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: B A
authors.initials: BA
authors.lastname: Oostra
authors.forename: E A P
authors.initials: EA
authors.lastname: Steegers
mesh_terms: D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D005787:Gene Frequency; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D010375:Pedigree; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy
chemical_list: D002352:Carrier Proteins; C500784:STOX1 protein, human