title: Diffuse large B-cell lymphoma in hyperimmunoglobulinemia E syndrome.
abstract: We report a case of diffuse large B-cell lymphoma occurring in a patient with the hyperimmunoglobulinemia E syndrome, a rare immune disorder defined by elevated immunoglobulin E levels and recurrent bacterial and fungal infections often manifesting as cold abscesses. This case further supports the notion that patients with hyperimmunoglobulinemia E have an increased risk of lymphoid malignancies and should be closely monitored. Despite a theoretic risk of severe infectious complications, chemotherapy was well tolerated and resulted in a sustained complete remission.
authors.affiliation: Service d'Hématologie Adultes et Centre d'Etudes et de Recherche sur les Déficits Immunitaires Héréditaires, Hôpital Necker-Enfants Malades, 149-163 rue de Sèvres, 75743 Paris, France.
authors.forename: Nadège
authors.initials: N
authors.lastname: Wallet
authors.forename: David
authors.initials: D
authors.lastname: Ghez
authors.forename: Richard
authors.initials: R
authors.lastname: Delarue
authors.forename: Felipe
authors.initials: F
authors.lastname: Suarez
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Rubio
authors.forename: Alain
authors.initials: A
authors.lastname: Fischer
authors.forename: Danielle
authors.initials: D
authors.lastname: Canioni
authors.forename: Bruno
authors.initials: B
authors.lastname: Varet
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007589:Job Syndrome / Q000150:complications*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D000069283:Rituximab; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D007073:Immunoglobulin E; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide