Immunochromatographic strip test for rapid detection of nevirapine in plasma samples from human immunodeficiency virus-infected patients.
We report a novel one-step immunochromatographic strip test for the rapid, qualitative detection of nevirapine in plasma samples from human immunodeficiency virus-infected patients. The sensitivity was 100% (95% confidence interval [95% CI], 97.8 to 100%), and the specificity was 99.5% (95% CI, 97.2 to 99.9%). The limit of detection was 25 ng/ml. Immunochromatographic strip tests are simple, rapid, and cheap assays that could greatly facilitate drug level monitoring in resource-limited settings.
Cressey
Tim R
TR
Harvard School of Public Health, Harvard University, Boston, MA, USA.
Nangola
Sawitree
S
Tawon
Yardpiroon
Y
Pattarawarapan
Mookda
M
Lallemant
Marc
M
Tayapiwatana
Chatchai
C
D000328:Adult; D019380:Anti-HIV Agents / Q000097:blood*; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D016903:Drug Monitoring / Q000191:economics / Q000379:methods; D005260:Female; D015658:HIV Infections / Q000097:blood*; D006801:Humans; D007120:Immunochemistry; D019829:Nevirapine / Q000097:blood*
D019380:Anti-HIV Agents; D019829:Nevirapine