title: Causes of oxidative stress in Alzheimer disease.
abstract: Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the onset, progression and pathogenesis of the disease. The generation of reactive oxygen species (ROS) and its consequent cellular damage/response contributes to much of the hallmark AD pathology seen in susceptible neurons. The sources of ROS-mediated damage appear to be multi-faceted in AD, with interactions between abnormal mitochondria, redox transition metals, and other factors. In this review, we provide an overview of these potential causes of oxidative stress in AD.
authors.affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: B
authors.initials: B
authors.lastname: Su
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
authors.forename: G
authors.initials: G
authors.lastname: Perry
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D001253:Astrocytes / Q000502:physiology; D003300:Copper / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000502:physiology; D006031:Glycosylation; D006801:Humans; D007501:Iron / Q000378:metabolism; D017628:Microglia / Q000502:physiology; D008928:Mitochondria / Q000502:physiology; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017127:Glycation End Products, Advanced; D017382:Reactive Oxygen Species; D003300:Copper; D007501:Iron