Diagnostic value of histology and immunohistochemistry in myelodysplastic syndromes.
The histologic and immunohistochemical analysis of the bone marrow yields important information for the diagnosis of myelodysplastic syndromes (MDS), thereby often exceeding the information obtained by cytological analysis of smears. Notably, tissue-fibrosis, angiogenesis, or the abnormal localization of megakaryocytes and CD34+ progenitor cells can only be assessed histologically. Many of these parameters are also of prognostic significance. Moreover, evaluation of bone marrow histology is of crucial importance in cases with dry-tap or blood-contaminated marrow-smears, especially in hypoplastic states. Histologic/immunohistochemical investigation of the bone marrow therefore is strongly recommended for patients with (suspected) MDS, the minimum marker-panel suggested being CD31, CD34, and tryptase.
Horny
Hans-Peter
HP
Institute of Pathology, D-91522 Ansbach, Germany. horny@pathologie-ansbach.com
Sotlar
Karl
K
Valent
Peter
P
D015415:Biomarkers; D001856:Bone Marrow Examination / Q000379:methods; D006652:Histological Techniques; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D009190:Myelodysplastic Syndromes / Q000145:classification / Q000175:diagnosis* / Q000473:pathology
D015415:Biomarkers