title: Food-dependent exercise-induced anaphylaxis in childhood.
abstract: The clinical syndrome of food-dependent exercise-induced anaphylaxis (FDEIA) is typified by the onset of anaphylaxis during (or soon after) exercise which was preceded by the ingestion of the causal food allergen/s. In FDEIA, both the food allergen/s and exercise are independently tolerated. FDEIA is an uncommon allergic condition in childhood, but nonetheless is an important differential diagnosis to be considered when faced by a child who has experienced exercise-associated anaphylaxis. The diagnosis of FDEIA is heavily dependent on the clinical history. Allergy tests may need to be performed to a broad panel of food and food additives. Modified exercise challenges (performed with and without prior ingestion of food) are frequently required as allergy test results frequently return low-positive results. A diagnosis of FDEIA facilitates the safe independent return to exercise and reintroduction of foods for patients who otherwise may unnecessarily avoid exercise and/or restrict their diet. The natural history of FDEIA is unknown; however, a safe return is usually achieved when the ingestion of the causal food allergen/s and exercise are separated.
authors.affiliation: Children's Allergy Service, Evelina Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, King's College London, London, UK. georgedutoit@gmail.com
authors.forename: George
authors.initials: G
authors.lastname: Du Toit
mesh_terms: D000293:Adolescent; D000707:Anaphylaxis / Q000175:diagnosis* / Q000276:immunology; D002648:Child; D015444:Exercise; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008297:Male