title: Modular syntheses of multidentate ligands with variable N-donors: applications to tri- and tetracopper(I) complexes.
abstract: A general method for the preparation of multidentate ligands comprised of a multi-imine platform derived from 1,1,1-tris(aminomethyl)ethane or tris(aminoethyl)amine connected to bi- and tridentate N-donor chelates has been developed. The feasibility of the method has been demonstrated through the synthesis and characterization of a large set of these ligand types. Complexation to Cu(I) was accomplished for several cases, yielding tri- and tetracopper(I) complexes that have been characterized in solution by NMR spectroscopy and conductivity, and in the solid state by elemental analysis, mass spectrometry, and/or X-ray crystallography. These complexes are potentially useful for modeling multicopper protein active sites.
authors.affiliation: Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, 207 Pleasant St. SE, Minneapolis, MN 55455, USA.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Brown
authors.forename: Brandon
authors.initials: B
authors.lastname: Johnson
authors.forename: Sara
authors.initials: S
authors.lastname: Palavicini
authors.forename: Benjamin E
authors.initials: BE
authors.lastname: Kucera
authors.forename: Luigi
authors.initials: L
authors.lastname: Casella
authors.forename: William B
authors.initials: WB
authors.lastname: Tolman
mesh_terms: D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004553:Electric Conductivity; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*
chemical_list: D008024:Ligands; D003300:Copper; D009584:Nitrogen