title: Characterisation of lipid profiles in dogs with parvoviral enteritis.
abstract: OBJECTIVE
  To characterise the lipid profiles in dogs with parvoviral enteritis.
  
  
  METHODS
  Blood was collected before treatment from 30 dogs that fulfilled the criteria for severe sepsis including hypo- or hyperthermia, hypotension, leucopenia, thrombocytopenia and evidences of organ dysfunction. Canine parvovirus was detected by haemagglutination and indirect fluorescence antibody tests in the faeces. Twenty control dogs were also enrolled on the basis of normal physical examination results, complete blood count and serum biochemistry profiles.
  
  
  RESULTS
  Tachycardia, tachypnoea, hypotension, leucopenia, thrombocytopenia and increased serum markers of tissue injury (alanine aminotransferase, creatinine kinase myocardial isoenzyme [CK-MB], blood urea nitrogen and creatinine) were observed in dogs with parvoviral enteritis. Serum total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels were lower, but serum triglyceride level was higher in dogs with parvoviral enteritis than those in control dogs (P<0.001). Circulating tumour necrosis factor alpha correlated negatively with total cholesterol (r=-0.979; P<0.001) but positively with triglyceride (r=0.953; P<0.001) in dogs with parvoviral enteritis. Serum total cholesterol and high-density lipoprotein cholesterol levels were lower in non-survival (n=9) dogs than in survival dogs (n=21, P<0.001).
  
  
  CONCLUSIONS
  Serum total cholesterol and high-density lipoprotein cholesterol levels decreased, but serum triglyceride level increased in dogs with parvoviral enteritis. Low serum total cholesterol and high-density lipoprotein cholesterol levels may be used as an index of the severity of parvoviral enteritis.
authors.affiliation: Department of Internal Medicine, Faculty of Veterinary Medicine, Uludag University, 16190 Bursa, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Yilmaz
authors.forename: S
authors.initials: S
authors.lastname: Senturk
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D004283:Dog Diseases / Q000097:blood* / Q000473:pathology; D004285:Dogs; D004751:Enteritis / Q000097:blood / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D005260:Female; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D010322:Parvoviridae Infections / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D017993:Parvovirus, Canine / Q000302:isolation & purification*; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008055:Lipids; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol