Hodgkin lymphoma in two siblings with common variable immunodeficiency.
Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by decreased serum immunoglobulin levels, and increased susceptibility to recurrent bacterial infections, malignancies, and autoimmune disorders. In this report, 2 siblings with CVID who developed Hodgkin lymphoma are presented: a 16-year-old girl at stage IIB and her 12-year-old brother at stage IIIB of Hodgkin lymphoma. Their father and 1 uncle were also affected by the same cancer with no immunodeficiency state. The presence of lymphoma should be considered in the patients with CVID, especially in those with family history of malignancies.
Aghamohammadi
Asghar
A
Department of Allergy and Clinical Immunology of Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran. aghamohammadi@sina.tums.ac.ir
Rezaei
Nima
N
Gharagozlou
Mohammad
M
Ramyar
Asghar
A
Mahjoub
Fatemeh
F
Rezaei-Kalantari
Kiara
K
Moin
Mostafa
M
D000293:Adolescent; D002648:Child; D017074:Common Variable Immunodeficiency / Q000150:complications*; D004198:Disease Susceptibility; D005192:Family Health; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D035781:Siblings