title: [Usefulness of equations based on serum cystatin C concentration in the study of renal function].
abstract: Serum creatinine is an insensitive marker to identify early changes in glomerular filtration rate (GFR), for this reason alternative methods to estimate renal function result of great clinical importance. Forty-one patients were studied using creatinine clearance modified with cimetidina (Clcrc) as surrogate of GFR, cystatin C-based equations (i.e. Larsson and Hoek formulas), Cockroft-Gault and MDRD abbreviated equations. In the whole group, as well as in those patients with serum creatinine < or =1.2 mg/dl--but reduced renal function: Clcrc 62.01 +/- 17.33 ml/ min/1.73 m(2)-, Larsson and Hoek equations showed higher correlations and lower bias than creatinine-based formulas. Abbreviated MDRD equation showed good performance just in those patients with evident alteration of renal function (serum creatinine > 1.2 mg/dl). We concluded that in patients with different stages of renal function, cystatin C-based equations detect reduction of renal function earlier than the serum creatinine-based formulas.
authors.affiliation: Servicio de Nefrologia, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina.
authors.forename: Carlos
authors.initials: C
authors.lastname: Chiurchiu
authors.forename: Nilda
authors.initials: N
authors.lastname: Garces
authors.forename: Gabriela
authors.initials: G
authors.lastname: Garay
authors.forename: Rosmarie
authors.initials: R
authors.lastname: Holtz
authors.forename: Walter
authors.initials: W
authors.lastname: Douthat
authors.forename: Javier
authors.initials: J
authors.lastname: de Arteaga
authors.forename: Raul
authors.initials: R
authors.lastname: Capra
authors.forename: Pablo U
authors.initials: PU
authors.lastname: Massari
mesh_terms: D015415:Biomarkers / Q000097:blood; D002927:Cimetidine / Q000008:administration & dosage; D003404:Creatinine / Q000037:antagonists & inhibitors / Q000097:blood*; D055316:Cystatin C; D015891:Cystatins / Q000037:antagonists & inhibitors / Q000097:blood*; D003627:Data Interpretation, Statistical; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D004791:Enzyme Inhibitors; D002927:Cimetidine; D003404:Creatinine