title: Cucurbitane glycosides from unripe fruits of Siraitia grosvenori.
abstract: Studies on the constituents of the unripe fruits of Siraitia grosvenori led to the isolation of three new cucurbitane triterpene glycosides, 11-oxomogroside III (10), 11-dehydroxymogroside III (11), and 11-oxomogroside IV A (12). Their structures were determined on the basis of detailed analyses of 1D, 2D-NMR spectroscopic methods. All of the compounds isolated from the unripe fruits of S. grosvenori were tested for cytotoxic activities against tumor cells, HCT-116 and SMMC-7721.
authors.affiliation: Faculty of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan.
authors.forename: Dianpeng
authors.initials: D
authors.lastname: Li
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ikeda
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nohara
authors.forename: Jinlei
authors.initials: J
authors.lastname: Liu
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Wen
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Gen-Ichiro
authors.initials: G
authors.lastname: Nonaka
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019662:Cucurbitaceae; D005638:Fruit / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure
chemical_list: C522659:11-dehydroxymogroside III; C522658:11-oxomogroside III; C522660:11-oxomogroside IV A; D006027:Glycosides