title: Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancer.
abstract: The past decade has seen pronounced changes in the treatment of locally advanced rectal cancer. Historically, the standard of care involved surgery followed by adjuvant radiotherapy or chemoradiotherapy. More recently, the emergence of neo-adjuvant chemoradiotherapy has fundamentally changed the management of patients with locally advanced disease. In clinical trials, pathological complete responses of up to 25% have raised the question as to whether surgery can be avoided in a select cohort of patients. A trial of omission of surgery for selected patients with complete response after preoperative chemoradiotherapy has shown favourable long-term results. In this article, we outline emerging factors for achieving pathological complete response, non-operative strategies to date, methods for prediction of response to chemoradiotherapy, and future directions with the addition of MRI as a radiological guide to complete response.
authors.affiliation: Department of Clinical Oncology, Royal Marsden Hospital, Sutton, Surrey, UK. brian.o'neill@rmh.nhs.uk
authors.forename: Brian D P
authors.initials: BD
authors.lastname: O'Neill
authors.forename: Gina
authors.initials: G
authors.lastname: Brown
authors.forename: R J
authors.initials: RJ
authors.lastname: Heald
authors.forename: David
authors.initials: D
authors.lastname: Cunningham
authors.forename: Diana M
authors.initials: DM
authors.lastname: Tait
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D020360:Neoadjuvant Therapy; D011237:Predictive Value of Tests; D011300:Preoperative Care; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed