title: Mechanisms and classifications of Chronic Obstructive Pulmonary Disease: a literature review.
abstract: COPD is a prevalent chronic health condition secondary to only heart disease and stroke. A review of the literature reveals whilst smoking is the most common aetiological factor, environmental and occupational pollutions, genetic predisposition, hyper-responsive airways and respiratory infections are additional mechanisms to the development of COPD in susceptible individuals. Assessment of the severity of COPD via spirometry is considered the gold standard in quantifying the degree of respiratory impairment experienced by the client with the condition. However, there are inconsistent parameters of disease severity between each of the international respiratory bodies, which must influence reporting of outcomes. This paper reviews the literature reports of the mechanisms; systemic effects, disease-staging systems used in COPD and the relationship between disease severity and health outcomes.
authors.affiliation: Faculty of Health Sciences, ACU National and Department of Nursing & Ambulatory Care Services, Austin Health, Fitzroy VIC, Australia.
authors.forename: Maria
authors.initials: M
authors.lastname: Murphy
authors.forename: John E
authors.initials: JE
authors.lastname: Saunders
authors.forename: Michelle
authors.initials: M
authors.lastname: Campbell
mesh_terms: D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology*; D012720:Severity of Illness Index; D013147:Spirometry