Synthesis, spectroscopic and cytotoxic studies of biologically active new schiff bases derived from p-nitrobenzaldehyde.
Thirteen new Schiff bases derived from p-nitrobenzaldehyde were synthesized by condensation with the appropriate amines. An unusual reduction of the p-nitrobenzaldehyde to the corresponding alcohol was also observed in one of the reactions. The structures of the compounds were identified using spectroscopic techniques. Cytotoxicity for the titled compounds was studied against Brine Shrimp, used as the test animal.
Iqbal
Amjid
A
Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
Siddiqui
Hamid Latif
HL
Ashraf
Chaudhary Muhammad
CM
Bukhari
Mujahid Hussain
MH
Akram
Chaudhary Muhammad
CM
D000588:Amines / Q000737:chemistry; D000818:Animals; D001156:Artemia / Q000187:drug effects*; D001547:Benzaldehydes / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology*; D018675:Toxicity Tests
D000588:Amines; D001547:Benzaldehydes; D012545:Schiff Bases; C029915:4-nitrobenzaldehyde