Polymorphisms of androgen receptor gene in childhood and adolescent males with first-onset major depressive disorder and association with related symptomatology.
This study was designed to explore the association between CAG repeats in AR gene and major depressive disorder (MDD) in male children and adolescents. The results showed that there were differences between adolescent depressive patients and adolescent controls in CAG repeats' length and alleles' distributions, and the severity of depression and anxiety was negatively correlated with the length of CAG repeats in adolescent patients. This suggested that AR gene might be involved in the depressive upset in adolescents, and the age- and sex-related prevalent differences might also be associated to CAG repeats.
Su
Qiao-Rong
QR
The Medical School of Shaoxing College of Arts and Sciences, Shaoxing, Zhejiang, People's Republic of China.
Su
Lin-Yan
LY
Su
Hong-Ri
HR
Chen
Qing
Q
Ren
Guang-Yuan
GY
Yin
You
Y
Shen
Shao-Qing
SQ
Yu
Ai-Yue
AY
Xia
Guo-Yuan
GY
D000293:Adolescent; D017677:Age Distribution; D016022:Case-Control Studies; D002648:Child; D003865:Major Depressive Disorder / Q000235:genetics* / Q000523:psychology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics*; D012016:Reference Values; D012720:Severity of Illness Index; D018911:Trinucleotide Repeats / Q000235:genetics*
D011944:Receptors, Androgen