title: [Variceal upper digestive bleeding--an ever new complication in liver cirrhosis].
abstract: Variceal bleeding in liver cirrhosis is a medical emergency with a high mortality. The therapeutic options in patients with portal hypertension are: treatment of acute bleeding from varices, prevention of the first bleeding episode and prevention of rebleeding. Treatment of acute bleeding from varices includes: blood volume restitution, use of antibiotics for preventing bacterial infections, vasoactive drug therapy (terlipressin, somatostatin, vapreotide, octreotide), endoscopic band ligation for acute esophageal bleeding and endoscopic therapy with tissue adhesive (cyanoacrylate) for acute gastric variceal bleeding. Endoscopic treatments are best used in association with pharmacological therapy. In primary prophylaxis non-selective beta- blocker therapy and endoscopic band ligation are useful. Beta blockers, band ligation or both should be used for prevention of recurrent bleeding. In patients who fail endoscopic and pharmacological treatment for prevention of rebleeding TIPS and transplantation should be considered.
authors.affiliation: Institutul de Gastroenterologie si Hepatologie, Facultatea de Medicină, Universitatea de Medicină si Farmacie "Gr. T. Popa", Iaşi.
authors.forename: Cristina Cijevschi
authors.initials: CC
authors.lastname: Prelipcean
authors.forename: I
authors.initials: I
authors.lastname: Sporea
authors.forename: Cătălina
authors.initials: C
authors.lastname: Mihai
authors.forename: P
authors.initials: P
authors.lastname: Gogălniceanu
authors.forename: V L
authors.initials: VL
authors.lastname: Drug
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004932:Esophageal and Gastric Varices / Q000150:complications* / Q000209:etiology / Q000628:therapy; D006471:Gastrointestinal Hemorrhage / Q000209:etiology* / Q000628:therapy; D016558:Hemostasis, Endoscopic / Q000379:methods; D006801:Humans; D008026:Ligation; D008103:Liver Cirrhosis / Q000150:complications* / Q000628:therapy; D015911:Sclerotherapy / Q000379:methods; D014014:Tissue Adhesives / Q000627:therapeutic use; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014014:Tissue Adhesives; D014662:Vasoconstrictor Agents