Field evaluation of a rota- and adenovirus immunochromatographic assay using stool samples from children with acute diarrhea in Ghana.
We evaluated the Rida Quick rotavirus/adenovirus Combi rapid immunochromatographic test (ICT) under field conditions with Ghanaian children with acute diarrhea. Compared to PCR results, sensitivities and specificities were 75% and 95% for rotavirus and 22% and 84% for adenovirus. In resource-poor settings, ICTs may help to overcome difficulties in the diagnosis of rotavirus infection.
Weitzel
Thomas
T
Institute of Tropical Medicine and International Health, Charité, University Medicine Berlin, Spandauer Damm 130, D-14050 Berlin, Germany. thomas.weitzel@charite.de
Reither
Klaus
K
Mockenhaupt
Frank P
FP
Stark
Klaus
K
Ignatius
Ralf
R
Saad
Eiman
E
Seidu-Korkor
Andrew
A
Bienzle
Ulrich
U
Schreier
Eckart
E
D000256:Adenoviridae / Q000302:isolation & purification*; D000257:Adenoviridae Infections / Q000175:diagnosis / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D002846:Chromatography, Affinity / Q000379:methods*; D003967:Diarrhea / Q000821:virology; D005869:Ghana; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016133:Polymerase Chain Reaction; D012401:Rotavirus / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000175:diagnosis / Q000821:virology*; D012680:Sensitivity and Specificity; D014773:Virology / Q000379:methods*