title: Evaluation of the EIE-IgM-Leptospirose assay for the serodiagnosis of leptospirosis.
abstract: Access to low-cost, effective diagnosis for leptospirosis is urgently needed in developing countries. The EIE-IgM-Leptospirose, a kit produced for public health laboratories in Brazil, was shown to have a sensitivity of 76% (77 of 102 patients) and 100% (102 of 102 patients) during acute and convalescent-phase leptospirosis, respectively, and a specificity of 93-100% (total healthy and patient control subjects evaluated, 486). These findings indicate that the assay will be useful for diagnosis of this emerging infectious disease in Brazil and other developing countries.
authors.affiliation: Gonçalo Moniz Research Centre, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Brazil.
authors.forename: Alan J A
authors.initials: AJ
authors.lastname: McBride
authors.forename: Fernanda A
authors.initials: FA
authors.lastname: Pereira
authors.forename: Emilson D
authors.initials: ED
authors.lastname: da Silva
authors.forename: Rosan B
authors.initials: RB
authors.lastname: de Matos
authors.forename: Edimilson D
authors.initials: ED
authors.lastname: da Silva
authors.forename: Antônio G P
authors.initials: AG
authors.lastname: Ferreira
authors.forename: Mitermayer G
authors.initials: MG
authors.lastname: Reis
authors.forename: Albert I
authors.initials: AI
authors.lastname: Ko
mesh_terms: D001938:Brazil / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D007922:Leptospirosis / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology*; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D012698:Serologic Tests
chemical_list: D007075:Immunoglobulin M; D011933:Reagent Kits, Diagnostic