Rescue of the streptomycin antibiotic activity by using streptidine as a "decoy acceptor" for the aminoglycoside-inactivating enzyme adenyl transferase.
The use of streptidine as a "decoy acceptor" allows the antibiotic activity of streptomycin to recover against the Escherichia coli strain overexpressing the aminoglycoside-modifying enzyme 6-O-adenyl transferase.
Latorre
Montserrat
M
Departamento de Química Orgánica Biológica, Instituto de Química Orgánica General, CSIC, Madrid 28006, Spain.
Peñalver
Pablo
P
Revuelta
Julia
J
Asensio
Juan Luis
JL
García-Junceda
Eduardo
E
Bastida
Agatha
A
D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006595:Hexosamines / Q000494:pharmacology*; D013307:Streptomycin / Q000494:pharmacology*; D014166:Transferases / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006146:Guanidines; D006595:Hexosamines; C005733:streptidine; D014166:Transferases; D013307:Streptomycin