Tongue base metastasis from neuroendocrine endometrial small cell carcinoma.
The endometrial small cell carcinoma (ESCC) is a rare and aggressive malignancy with an estimated prevalence of less than 1% of endometrial carcinomas. Endometrial small cell carcinoma is frequently diagnosed at an advanced stage and has a poor prognosis. Although the most common presenting sign of ESCC is definitely a peri- or postmenopausal vaginal bleeding, we report for the first time the occurrence of tongue base bleeding as first manifestation of disseminated neuroendocrine ESCC. From a clinical viewpoint, tongue metastasis from primary endometrial carcinoma is a manifestation of widespread disease. Albeit, our patient underwent complete hysterectomy and postoperative chemotherapy, she died of disseminated disease 3 months after ESCC diagnosis.
Marioni
Gino
G
Section of Otolaryngology, Department of Medical and Surgical Specialties, University of Padova, Padova, Italy. gino.marioni@unipd.it
Savastano
Marina
M
Mattiello
Laura
L
Koussis
Haralabos
H
Carpenè
Silvia
S
Marino
Filippo
F
Staffieri
Alberto
A
D000970:Antineoplastic Agents / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014062:Tongue Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*
D000970:Antineoplastic Agents