Treatment leading to dramatic recovery in acute hemorrhagic leukoencephalitis.
The clinical course, neuroimaging, neuropathological features, and management of a 7-year-old girl with acute hemorrhagic leukoencephalitis are reported. Treatment with subtotal bifrontal craniectomies for symptoms of imminent uncal herniation followed by high-dose corticosteroid therapy was associated with dramatic clinical recovery. This report highlights the utility of aggressive intervention in acute hemorrhagic leukoencephalitis, an otherwise fatal disorder.
Payne
Eric T
ET
Department of Pediatrics, Divisions of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Rutka
James T
JT
Ho
Tommy K
TK
Halliday
William C
WC
Banwell
Brenda L
BL
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002648:Child; D003399:Craniotomy / Q000379:methods; D005260:Female; D006801:Humans; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000503:physiopathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging / Q000379:methods; D020127:Recovery of Function / Q000502:physiology*
D000305:Adrenal Cortex Hormones