Indanylacetic acids as PPAR-delta activator insulin sensitizers.
A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-alpha and PPAR-delta ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-delta over PPAR-alpha.
Wickens
Philip
P
Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. pcwickens@hotmail.com
Zhang
Chengzhi
C
Ma
Xin
X
Zhao
Qian
Q
Amatruda
John
J
Bullock
William
W
Burns
Michael
M
Cantin
Louis-David
LD
Chuang
Chih-Yuan
CY
Claus
Thomas
T
Dai
Miao
M
Dela Cruz
Fernando
F
Dickson
David
D
Ehrgott
Frederick J
FJ
Fan
Dongping
D
Heald
Sarah
S
Hentemann
Martin
M
Iwuagwu
Christiana I
CI
Johnson
Jeffrey S
JS
Kumarasinghe
Ellalahewage
E
Ladner
David
D
Lavoie
Rico
R
Liang
Sidney
S
Livingston
James N
JN
Lowe
Derek
D
Magnuson
Steve
S
Mannelly
Gretchen
G
Mugge
Ingo
I
Ogutu
Herbert
H
Pleasic-Williams
Susan
S
Schoenleber
Robert W
RW
Shapiro
Jeff
J
Shelekhin
Tatiana
T
Sweet
Laurel
L
Town
Christopher
C
Tsutsumi
Manami
M
D031541:Fluorescence Resonance Energy Transfer; D007333:Insulin Resistance; D047494:PPAR delta / Q000819:agonists*; D013329:Structure-Activity Relationship
D047494:PPAR delta