Pathologically different features and fibrosis scores in chronic hepatitis C genotypes 3 and 1.
BACKGROUND
Chronic hepatitis C genotypes 3 and 1 are the two most common genotypes in Thailand.


OBJECTIVE
Identify the pathologically different features between genotypes 3 and land to compare the fibrosis score of Knodell HAI and Ishak modified HAI.


METHODS
The pathological features of 114 liver biopsies were evaluated.


RESULTS
Steatosis was more commonly found in genotype 3 than in genotype 1 (97.1% vs. 77.8%, p = 0.001). Portal lymphoid follicles were commonly found, but bile duct damage was uncommon. The majority of portal tracts showed partial involvement. The majority of patients had Knodell fibrosis 1 and Ishak fibrosis 3.


CONCLUSIONS
Steatosis is significantly more common in genotype 3, while other features do not show any differences. The portal tracts show partial involvement because inflammatory cells tend to aggregate and form lymphoid follicles. The most comparable fibrosis scores are Knodell fibrosis 1 and Ishak fibrosis 3.
Manuyakorn
Ananya
A
Department of Pathology, Faculty of Medicine Siriraj Hospital, 2 Pran-nok Rd, Bangkok-noi, Bangkok 10700, Thailand. siama@mahidol.ac.th
Tanwandee
Tawesak
T
Atisook
Kanit
K
D000328:Adult; D001706:Biopsy; D005234:Fatty Liver / Q000235:genetics / Q000473:pathology; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013785:Thailand