Ubiquitin ligation without a ligase.
Classically, ubiquitination requires three enzymes acting in sequence: E1, E2, and E3. E3 ubiquitin ligases typically provide substrate specificity. An article in Molecular Cell (Hoeller et al., 2007) now describes the E3-independent monoubiquitination of certain proteins. The mechanism has interesting parallels to SUMO ligation.
Hochstrasser
Mark
M
Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA. mark.hochstrasser@yale.edu
D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D025801:Ubiquitin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases
D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases