Clinical and in vitro efficacy of amoxicillin against bacteria associated with feline skin wounds and abscesses.
A clinical trial involving 122 cats with infected skin wounds or abscesses presented to 10 veterinary clinics was conducted to evaluate the efficacy of 2 oral amoxicillin drug products (a paste and a suspension). A 2nd objective of the study was to identify bacteria involved in such infections and verify their in vitro sensitivity to amoxicillin. Samples of wound exudate were harvested at the time of presentation and submitted for aerobic and anaerobic culture. The sensitivity to amoxicillin of isolates thought to be infecting agents was tested, using a standard minimum inhibitory concentration method. Pasteuralla multocida and obligate anaerobes of the genera Prevotella, Fusobacterium, and Porphyromonas were the most frequently isolated pathogens. Overall, their in vitro susceptibility to amoxicillin was very good. Both drug products were clinically efficacious with a global success rate of 95.1% for cats administered oral amoxicillin at 11-22 mg/kg bodyweight (mean 13.8 mg/kg bodyweight) twice daily for 7 to 10 days.
Roy
Josée
J
Vétoquinol Canada, 2000 Georges, Lavaltrie, Québec J5T 3S5. jroy@vetoquinol.ca
Messier
Serge
S
Labrecque
Olivia
O
Cox
William R
WR
D000038:Abscess / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D000284:Administration, Oral; D000658:Amoxicillin / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy* / Q000382:microbiology; D002415:Cats; D005260:Female; D008297:Male; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D009824:Ointments / Q000627:therapeutic use; D010326:Pasteurella Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary; D016979:Pasteurella multocida / Q000187:drug effects; D012867:Skin / Q000293:injuries*; D013535:Suspensions / Q000627:therapeutic use; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*
D000900:Anti-Bacterial Agents; D009824:Ointments; D013535:Suspensions; D000658:Amoxicillin