title: Hepatitis B immune globulin.
abstract: Hepatitis B immune globulin (HBIG) is a purified solution of human immunoglobulin that has high titers of antibody to hepatitis B surface antigen (anti-HBs). It is derived from plasma donated by individuals immune to hepatitis B viral infection. HBIG is widely administered to confer passive prophylactic immunity against the hepatitis B virus because of the ability of anti-HBs to neutralize hepatitis B virions. However, it is not indicated for the treatment of acute or chronic hepatitis B. The use of HBIG is recommended in the following clinical situations: i) Acute exposure to blood and secretions containing hepatitis B surface antigen (HBsAg); ii) sexual contact with HBsAg-positive persons; iii) household exposure to persons with acute hepatitis B; iv) perinatal exposure of infants born to HBsAg-positive mothers; v) liver transplantation.
authors.affiliation: Center for Liver Diseases, Iowa Health Des Moines, Des Moines, IA, USA.
authors.forename: Shahid
authors.initials: S
authors.lastname: Habib
authors.forename: Obaid S
authors.initials: OS
authors.lastname: Shaikh
mesh_terms: D004347:Drug Interactions; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D006510:Hepatitis B Antibodies / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D016031:Liver Transplantation; D008297:Male; D011247:Pregnancy; D012008:Recurrence
chemical_list: D006510:Hepatitis B Antibodies; D007136:Immunoglobulins