title: [Correlative analysis of postpartum depression].
abstract: OBJECTIVE
  To explore the incidence of postpartal depression in the south and north and to comprehensively analyze the changes of sex hormone and neurotransmitter,and their relationship with postpartum depression.
  
  
  METHODS
  All published articles on case-control studies on the changes of sex hormone and neurotransmitter,and their relationship with postpartum depression were collected by literature retrieval based on the selection criteria. Meta-analysis was applied to evaluate the data in published papers from 1994 to 2004 in China.
  
  
  RESULTS
  The incidence of postpartal depression in the south was 15.63%. The combined P-valve was 0.0874, and 95% CI was 0.14 to 0.17. The incidence of postpartum depression in the north was 7.66%. The combined P-valve was 0.0252, and 95% CI was 0.05 to 0.08. There was significant difference between the incidence of postpartum depression in the south and north (P<0.01). Estrogen and 5-HT in the plasma of the 1st week after childbirth was obviously lower than the controls. Estrogen in the plasma of the 1st week after childbirth and the 6th week after childbirth decreased more quickly than the controls. Progesterone and orphanin FQ in the plasma of the 1st week after childbirth were higher than the controls.
  
  
  CONCLUSIONS
  The incidence of postpartum depression in the south is higher than that of the north. Postpartum depression is related to the decrease in the plasma estrogen, 5-HT, dopamine, and noradrenaline, and to the increase in the plasma progesterone and Orphanin FQ.
authors.affiliation: School of Nursing, Central South University, Changsha 410013, China. Ly603202@sina.com
authors.forename: Yang
authors.initials: Y
authors.lastname: Luo
authors.forename: Guo-ping
authors.initials: GP
authors.lastname: He
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D019052:Depression, Postpartum / Q000097:blood* / Q000453:epidemiology*; D004967:Estrogens / Q000097:blood; D005260:Female; D006801:Humans; D015994:Incidence; D018377:Neurotransmitter Agents / Q000097:blood; D011374:Progesterone / Q000097:blood; D012701:Serotonin / Q000097:blood
chemical_list: D004967:Estrogens; D018377:Neurotransmitter Agents; D012701:Serotonin; D011374:Progesterone