Production of optically active 1,2,4-butanetriol from corresponding racemate by Microbial stereoinversion.
Sterigmatomyces elviae DSM 70852 produced 12 g/l (S)-1,2,4-butanetriol (enantiomeric excess >99.9%) from 20 g/l racemate in 82 h. From the results of the inversion of an (R)-isomer to an (S)-isomer and GC-MS, it was suggested that (R)-1,2,4-butanetriol is oxidized to 1,4-dihydroxy-2-butanone, which is reduced to an (S)-isomer.
Yamada-Onodera
Keiko
K
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Japan. onoderak@bs.naist.jp
Norimoto
Akihiro
A
Kawada
Naoki
N
Furuya
Rika
R
Yamamoto
Hiroaki
H
Tani
Yoshiki
Y
D000440:Butanols / Q000737:chemistry* / Q000302:isolation & purification*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism*
D000440:Butanols; C114589:1,3,4-butanetriol