title: Novel chloroenyne-modified amino acid derivatives.
abstract: Three groups of chloroenyne-modified amino acids were synthesized. Chloroenyne moiety was attached at the N- or C-terminal amino acid (Tyr, Phe, Val, Gly, Lys) position carrying different protecting groups. Prepared derivatives will be used as building blocks in the synthesis of enediyne-peptide conjugates. Furthermore, reactivity of modified amino acids in the peptide bond formation reaction was tested.
authors.affiliation: Division of Organic Chemistry and Biochemistry, Ruder Bos ković Institute, Zagreb, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Gredicak
authors.forename: A
authors.initials: A
authors.lastname: Kolonić
authors.forename: I
authors.initials: I
authors.lastname: Jerić
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D010455:Peptides