title: Successful delivery after the transfer of embryos obtained from a cohort of incompletely in vivo matured oocytes at retrieval time.
abstract: OBJECTIVE
  To report a case of successful delivery of a healthy baby after intracytoplasmic sperm injection (ICSI) in a patient with no mature oocytes at the time of oocyte retrieval.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Department of Reproductive Medicine.
  
  
  METHODS
  After a controlled ovarian hyperstimulation cycle, a total of seven immature oocytes were collected.
  
  
  METHODS
  Medical management.
  
  
  METHODS
  The timing of polar body extrusion was checked every 2 hours, and ICSI was performed as soon as the first polar body was extruded.
  
  
  RESULTS
  Following incubation in culture medium, five oocytes reached the metaphase II stage within 8-8.5 hours. Three oocytes were fertilized after ICSI, and two of three cleaved embryos were transferred on day 3. The embryo transfer was followed by a single pregnancy and the delivery of a healthy baby.
  
  
  CONCLUSIONS
  This case report demonstrates that embryos obtained from in vitro matured oocytes retain the developmental competence for full-term. It illustrates the importance of regularly monitoring the polar body extrusion when all collected oocytes are immature.
authors.affiliation: Laboratoire de Biologie de la Reproduction, Hôpital Cochin, AP-HP, Université René-Descartes, Paris, France. patricia.fauque@cch.aphp.fr
authors.forename: Patricia
authors.initials: P
authors.lastname: Fauque
authors.forename: Juliette
authors.initials: J
authors.lastname: Guibert
authors.forename: Pierre
authors.initials: P
authors.lastname: Jouannet
authors.forename: Catherine
authors.initials: C
authors.lastname: Patrat
mesh_terms: D000328:Adult; D004334:Drug Administration Schedule; D046149:Embryo Culture Techniques; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D006801:Humans; D007246:Infertility / Q000628:therapy*; D050498:Live Birth; D008297:Male; D054315:Oocyte Retrieval; D009865:Oocytes / Q000187:drug effects*; D009866:Oogenesis / Q000187:drug effects*; D010062:Ovulation Induction; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D013997:Time Factors
chemical_list: D005300:Fertility Agents, Female