title: Sensitive voltammetric determination of chloramphenicol by using single-wall carbon nanotube-gold nanoparticle-ionic liquid composite film modified glassy carbon electrodes.
abstract: A novel composite film modified glassy carbon electrode has been fabricated and characterized by scanning electron microscope (SEM) and voltammetry. The composite film comprises of single-wall carbon nanotube (SWNT), gold nanoparticle (GNP) and ionic liquid (i.e. 1-octyl-3-methylimidazolium hexafluorophosphate), thus has the characteristics of them. The resulting electrode shows good stability, high accumulation efficiency and strong promotion to electron transfer. On it, chloramphenicol can produce a sensitive cathodic peak at -0.66 V (versus SCE) in pH 7.0 phosphate buffer solutions. Parameters influencing the voltammetric response of chloramphenicol are optimized, which include the composition of the film and the operation conditions. Under the optimized conditions, the peak current is linear to chloramphenicol concentration in the range of 1.0x10(-8)-6.0x10(-6) M, and the detection limit is estimated to be 5.0x10(-9) M after an accumulation for 150 s on open circuit. The electrode is applied to the determination of chloramphenicol in milk samples, and the recoveries for the standards added are 97.0% and 100.3%. In addition, the electrochemical reaction of chloramphenicol and the effect of single-wall carbon nanotube, gold nanoparticle and ionic liquid are discussed.
authors.affiliation: Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.forename: Faqiong
authors.initials: F
authors.lastname: Zhao
authors.forename: Jiangwen
authors.initials: J
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Yan
authors.forename: Jingjing
authors.initials: J
authors.lastname: Yu
authors.forename: Baizhao
authors.initials: B
authors.lastname: Zeng
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002244:Carbon / Q000737:chemistry; D002701:Chloramphenicol / Q000032:analysis*; D004566:Electrodes; D005898:Glass / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008892:Milk / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D011199:Potentiometry / Q000379:methods*
chemical_list: C446740:1-octyl-3-methylimidazolium hexafluorophosphate; D000900:Anti-Bacterial Agents; D007093:Imidazoles; D052578:Ionic Liquids; D037742:Nanotubes, Carbon; D002701:Chloramphenicol; D002244:Carbon; D006046:Gold