Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status.
BACKGROUND
It has been observed that ras-transformed cell lines in culture have a higher phosphatidylcholine (PC) biosynthesis rate as well as higher PC-degradation rate (increased PC-turnover) than normal cells. In correspondence to these findings, the concentrations of the PC-degradation product lyso-phosphatidylcholine (LPC) in cancer patients were found to be decreased. Our objective was the systematic investigation of the relationship between LPC and inflammatory and nutritional parameters in cancer patients. Therefore, plasma LPC concentrations were assessed in 59 cancer patients and related to nutritional and inflammatory parameters. To determine LPC in blood plasma we developed and validated a HPTLC method.


RESULTS
Average plasma LPC concentration was 207 +/- 59 microM which corresponds to the lower limit of the reported range in healthy subjects. No correlation between LPC and age, performance status, body mass index (BMI) or fat mass could be seen. However, LPC correlated inversely with plasma C-reactive protein (CRP) and whole blood hydrogen peroxides (HPO). Further, a negative correlation could be observed between LPC and whole body extra cellular fluid volume (ECF) as well as with relative change in body weight since cancer diagnosis.


CONCLUSIONS
In conclusion, LPC concentrations were decreased in cancer patients. LPC plasma concentrations correlated with weight loss and inflammatory parameters and, therefore, might be a general indicator of severity of malignant disease.
Taylor
Lenka A
LA
Tumor Biology Center, Dept. of Clinical Research, Freiburg, Germany. taylor@tumorbio.uni-freiburg.de
Arends
Jann
J
Hodina
Arwen K
AK
Unger
Clemens
C
Massing
Ulrich
U
D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D045604:Extracellular Fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D007249:Inflammation / Q000276:immunology*; D008244:Lysophosphatidylcholines / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D012709:Serum Albumin / Q000378:metabolism; D015431:Weight Loss
D008244:Lysophosphatidylcholines; D012709:Serum Albumin; D002097:C-Reactive Protein; D006861:Hydrogen Peroxide