title: [Antioxidants, free radicals, mechanism of action and application in the therapy of the sulfur mustard caused injury].
abstract: Antioxidants perform an important role in the maintenance of the integrity of the living organisms. Recently, great attention has been given to antioxidants by a reason of their medical use. It is due to the association of many human diseases with oxidative stress. The present study briefly surveys the types of antioxidants, reactive oxygen and nitrogen species and describes the basic mechanisms of their activity. The application of antioxidants in the therapy of the injury caused by sulfur mustard, a vesicant type chemical warfare agent introduced in World War I, is also given.
authors.affiliation: Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické botaniky a ekologie. koleckar@pmfhk.cz
authors.forename: V
authors.initials: V
authors.lastname: Koleckár
authors.forename: E
authors.initials: E
authors.lastname: Brojerová
authors.forename: L
authors.initials: L
authors.lastname: Opletal
authors.forename: D
authors.initials: D
authors.lastname: Jun
authors.forename: K
authors.initials: K
authors.lastname: Kuca
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D002619:Chemical Warfare Agents / Q000506:poisoning*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D009151:Mustard Gas / Q000506:poisoning*; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D002619:Chemical Warfare Agents; D005609:Free Radicals; D009151:Mustard Gas