title: [Suppression of WIFI transcript and protein in non-small cell lung carcinomas].
abstract: Changes in WIFI expression, an extracellular inhibitor of Wnt pathway, in non-small cell lung carcinomas were analyzed. Frequent (67% cases) suppression of WIFI transcript in non-small cell lung carcinomas were found. Our results, together with previously published data, suggest that inhibition of WIFI expression often occurs in squamous cell carcinomas and is less typical of adenocarcinomas. It was also found that a decrease in the WIFI transcript in tumors is parallel to concomitant suppression of the WIFI protein level. Our results provide further evidence that the WIFI suppression is a frequent event in the lung carcinogenesis, which might lead to disregulation of Wnt signaling pathway and contribute to tumor progression.
authors.forename: E V
authors.initials: EV
authors.lastname: Korobko
authors.forename: S V
authors.initials: SV
authors.lastname: Kalinichenko
authors.forename: M V
authors.initials: MV
authors.lastname: Shepelev
authors.forename: I B
authors.initials: IB
authors.lastname: Zborovskaia
authors.forename: A K
authors.initials: AK
authors.lastname: Allakhverdiev
authors.forename: M V
authors.initials: MV
authors.lastname: Zinov'eva
authors.forename: T V
authors.initials: TV
authors.lastname: Vinogradova
authors.forename: E D
authors.initials: ED
authors.lastname: Sverdlov
authors.forename: I V
authors.initials: IV
authors.lastname: Korobko
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis* / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D012334:RNA, Neoplasm / Q000096:biosynthesis* / Q000235:genetics; D012097:Repressor Proteins / Q000096:biosynthesis* / Q000235:genetics; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D012097:Repressor Proteins; C485569:WIF1 protein, human; D051153:Wnt Proteins