Mycophenolic acid as a latent agonist of PPARgamma.
Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor gamma (PPARgamma).
Ubukata
Makoto
M
Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Kita-9, Nishi-9, Sapporo, Japan. m-ub@for.agr.hokudai.ac.jp
Takamori
Hitomi
H
Ohashi
Misaki
M
Mitsuhashi
Shinya
S
Yamashita
Kaoru
K
Asada
Tomohisa
T
Nakajima
Noriyuki
N
Matsuura
Nobuyasu
N
Tsuruga
Mie
M
Taki
Keiko
K
Magae
Junji
J
D041721:3T3-L1 Cells; D000818:Animals; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D008024:Ligands; D051379:Mice; D008956:Models, Chemical; D009173:Mycophenolic Acid / Q000494:pharmacology*; D047495:PPAR gamma / Q000819:agonists* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013997:Time Factors
D008024:Ligands; D047495:PPAR gamma; D009173:Mycophenolic Acid