Most expressed transcripts in sexual organs and other tissues.
This study characterizes the most highly expressed transcripts of 15 intact tissues in mice by using the serial analysis of gene expression (SAGE) strategy which indicates the relative level of expression for each transcript matched to the tag. We show that the most abundant transcripts in the prostate, testis, and skeletal muscle characterize the main functions of these organs as an exocrine gland of male reproduction, spermatogenesis, and contraction, respectively. In addition, the top nine most abundant transcripts in the testis are tissue-specific genes while the most abundant transcripts in the prostate are also abundantly expressed in the liver. Furthermore, the most abundant transcripts in the ovary, mammary gland, and vagina are related to steroidogenesis, adipocytes, and keratinization, respectively, whereas genes involved in the cell defence are abundantly expressed in the liver, lung, bone, mammary gland, and adipose tissue. These findings suggest that the top 10 transcripts are sufficient to characterize each tissue of the body.
Kouadjo
Kouame E
KE
Molecular Endocrinology and Oncology Research Center, Laval University Medical Center (CHUL), Department of Anatomy and Physiology, Laval University, 2705 Boulevard Laurier, Québec, Canada.
Yoshioka
Mayumi
M
Nishida
Yuichiro
Y
St-Amand
Jonny
J
D000818:Animals; D001842:Bone and Bones / Q000502:physiology; D001921:Brain / Q000502:physiology; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D020224:Expressed Sequence Tags; D005260:Female; D015870:Gene Expression; D008297:Male; D008321:Mammary Glands, Animal / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000502:physiology; D010053:Ovary / Q000502:physiology; D013737:Testis / Q000502:physiology; D014158:Transcription, Genetic; D014621:Vagina / Q000502:physiology
D003577:Cytochrome P-450 Enzyme System