title: Autoimmune hemolytic anemia in children.
abstract: The clinical and hematological profile and treatment outcome of children with warm autoimmune hemolytic anemia (AIHA) were assessed using retrospective case record analysis. There were 26 (17 idiopathic; 9 secondary) patients with a median age of 11 years. Pallor (100%), fever (39%), and jaundice (59%) were the main presenting complaints. Jaundice was much more common in idiopathic (70%) compared to secondary (44%). Direct antiglobulin test was negative in 3 patients. Oral prednisolone produced remission in 81% patients. Four patients relapsed after a median period of 7 months (2 months to 2 year) after response. All responded to a second course of steroids in median 14 days. One child required cyclosporin A in addition. No correlation was found between response and parameters such as age, sex, jaundice, low pretreatment hemoglobin, reticulocyte count, total leukocyte count, platelet count, subtype of AIHA, and hepatosplenomegaly. Relapse correlated with increased duration between the onset of symptoms and treatment. This study indicates that oral prednisolone is an effective therapy for autoimmune hemolytic anemia. In refractory cases cyclosporine A may be useful.
authors.forename: Rahul
authors.initials: R
authors.lastname: Naithani
authors.forename: Neerja
authors.initials: N
authors.lastname: Agrawal
authors.forename: M
authors.initials: M
authors.lastname: Mahapatra
authors.forename: Rajat
authors.initials: R
authors.lastname: Kumar
authors.forename: H P
authors.initials: HP
authors.lastname: Pati
authors.forename: V P
authors.initials: VP
authors.lastname: Choudhry
mesh_terms: D000293:Adolescent; D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever; D006801:Humans; D007223:Infant; D007565:Jaundice; D008297:Male; D010167:Pallor; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies
chemical_list: D011239:Prednisolone