Computational design of an RNA hexagonal nanoring and an RNA nanotube.
The combination of computer modeling, RNA structure versatility, and siRNA function can be efficiently used to design an all-RNA nanoparticle capable of siRNA delivery. Here, we present a computational design of an RNA nanoring and a nanotube. An RNA nanoring consists of six simple linear building blocks that are assembled together via known noncovalent loop-loop contacts based on RNAI/RNAII inverse sequences. The helical sequences of the building blocks can include siRNAs for drug delivery.
Yingling
Yaroslava G
YG
Center for Cancer Research Nanobiology Program, National Cancer Institute, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.
Shapiro
Bruce A
BA
D003198:Computer Simulation; D003460:Crystallization / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008956:Models, Chemical; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D010316:Particle Size; D012313:RNA / Q000737:chemistry* / Q000648:ultrastructure*; D013499:Surface Properties
D004337:Drug Carriers; D046911:Macromolecular Substances; D012313:RNA