POEMS syndrome: relapse after successful autologous peripheral blood stem cell transplantation.
We report a patient with POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) treated with high dose chemotherapy and auto-Peripheral Blood Stem Cell Transplantation (auto-PBSCT) who had a very good response with complete clinical remission. Seven years later, she relapsed and a new sclerotic bone lesion was found. To our knowledge, this is the first POEMS syndrome relapse after successful auto-PBSCT.
Giglia
F
F
Division of Biochemistry and Genetics, IRCCS Foundation, C. Besta Neurological Institute, Milan, Italy.
Chiapparini
L
L
Fariselli
L
L
Barbui
T
T
Ciano
C
C
Scarlato
M
M
Pareyson
D
D
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology*; D004358:Drug Therapy; D005260:Female; D006801:Humans; D010026:Osteosclerosis / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D016878:POEMS Syndrome / Q000503:physiopathology / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D016634:Radiosurgery; D012008:Recurrence; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A