title: [Suppression of gene transcription by polyamide - review].
abstract: Polyamide is a synthetic small molecule that recognizes predetermined sequences in the minor groove of DNA with affinities and specificities compared to those of DNA-binding proteins. Polyamide can suppress gene transcription by interfering with the attachment of natural transcription factors and DNA. The alkylating polyamides represent a novel approach for sequence-specific gene silencing, which might be applied to gene therapy. The research on suppression of gene transcription by polyamide was reviewed in this paper.
authors.affiliation: Department of Hematology, Peking Univesity First Hospital, Beijing 100034, China. zhuping@bjmu.edu.cn
authors.forename: Bin
authors.initials: B
authors.lastname: Chu
mesh_terms: D000818:Animals; D020868:Gene Silencing / Q000187:drug effects*; D006678:HIV / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D009757:Nylons / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D009757:Nylons