[The use of platelet rich plasma (PRP) and platelet rich fibrin (PRP) extracts in dental implantology and oral surgery].
Platelet-rich plasma (PRP), made from autologous blood, is being used to deliver growth factors in high concentration to sites requiring osseous grafting. Growth factors released from the platelets include Platelet-Derived Growth Factor (PDGF), Transforming Growth Factor Beta (TGF-b) and Insulin-Like Growth Factor 1 (IGF-1). These factors signal the local mesenchymal and epithelial cells to migrate, divide, and increase collagen and matrix synthesis. PRP has been suggested for use to increase the rate of bone deposition and quality of bone regeneration when augmenting sites prior to or in conjunction with dental implant placement. There is still lack of scientific evidence to support the use of PRP and PRF in combination with bone grafts during augmentation procedures. Further research is warranted.
Schwartz-Arad
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D
Dept. of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
Levin
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L
Aba
M
M
D016301:Alveolar Bone Loss / Q000209:etiology / Q000601:surgery*; D001792:Blood Platelets; D001861:Bone Regeneration / Q000187:drug effects; D016025:Bone Transplantation; D003758:Dental Implantation, Endosseous / Q000009:adverse effects*; D016503:Drug Delivery Systems; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D006133:Growth Substances / Q000008:administration & dosage; D006801:Humans; D053657:Platelet-Rich Plasma; D014014:Tissue Adhesives / Q000008:administration & dosage*
D015718:Fibrin Tissue Adhesive; D006133:Growth Substances; D014014:Tissue Adhesives