Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT.
A general theme in gene regulation is that transcription factors never function alone. Recent studies have emphasized this concept for regulatory T cells, a unique lineage of CD4+ T cells that exert active immune suppression and are essential to maintaining self-tolerance.
Hu
Hui
H
The CBR Institute for Biomedical Research and the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Djuretic
Ivana
I
Sundrud
Mark S
MS
Rao
Anjana
A
D000818:Animals; D050676:Core Binding Factor Alpha 2 Subunit / Q000502:physiology*; D051858:Forkhead Transcription Factors / Q000502:physiology*; D006801:Humans; D050778:NFATC Transcription Factors / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism*; D018808:Transcription Factor AP-1 / Q000502:physiology; D014158:Transcription, Genetic
D050676:Core Binding Factor Alpha 2 Subunit; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D050778:NFATC Transcription Factors; D018808:Transcription Factor AP-1