Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation.
We report a case of small cell lung cancer (SCLC) developing after prolonged treatment (more than 2 years) for primary adenocarcinoma of the lung, and we show that both the SCLC and non-small cell lung cancer (NSCLC) tissues obtained from the same site share the same deletion in exon 19 of EGFR. This case suggests that the activating EGFR mutations may confer the pathogenesis of a subset of SCLC.
Morinaga
Ryotaro
R
Department of Medical Oncology, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan.
Okamoto
Isamu
I
Furuta
Kazuyuki
K
Kawano
Yukiko
Y
Sekijima
Masaru
M
Dote
Kensaku
K
Satou
Takao
T
Nishio
Kazuto
K
Fukuoka
Masahiro
M
Nakagawa
Kazuhiko
K
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000473:pathology*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D015898:Tomography Scanners, X-Ray Computed
D066246:ErbB Receptors