title: Focal palmoplantar and gingival hyperkeratosis: a case report.
abstract: We report a rare genetic condition characterized by gingival hyperkeratosis with skin changes affecting the hands and feet. The patient presented with asymptomatic oral lesions and the diagnosis was reached by taking a full clinical history and biopsy tests. Palmoplantar keratosis can be a feature of a range of different syndromes and can be associated with periodontal destruction, benign oral keratosis or cancer of the oesophagus. It is important for dentists to be aware that clues to diagnosis can be gained from examination of the hands and feet, in addition to an oral examination, particularly in recognizing oral genetic disorders.
  
  
  CONCLUSIONS
  To inform clinicians of both the intra-oral and extra-oral features of focal palmoplantar and gingival hyperkeratosis.
authors.affiliation: The School of Dentistry, University of Manchester, Higher Cambridge Street, Manchester, M15 6FH, UK.
authors.forename: Jadbinder
authors.initials: J
authors.lastname: Seehra
authors.forename: Nalin
authors.initials: N
authors.lastname: Thakker
authors.forename: A John
authors.initials: AJ
authors.lastname: Duxbury
authors.forename: Philip
authors.initials: P
authors.lastname: Sloan
authors.forename: Senathirajah
authors.initials: S
authors.lastname: Ariyaratnam
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D005533:Foot Dermatoses / Q000473:pathology; D005882:Gingival Diseases / Q000473:pathology*; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013577:Syndrome