title: Association between arterial pressure and coronary artery calcification.
abstract: OBJECTIVE
  Coronary artery calcification (CAC) determined by electron beam computed tomography is a predictor of future cardiovascular events. This study investigates conditions affecting CAC severity in patients with coronary artery disease (CAD) undergoing coronary angiography.
  
  
  METHODS
  Presence and degree of CAC were assessed angiographically in 877 CAD patients grouped into no visible CAC (n = 333), mild to moderate CAC (n = 321), and severe CAC (n = 223). Regression analyses investigated relationships between CAC and demographic data, cardiovascular risk factors, and coronary anatomy.
  
  
  RESULTS
  Prevalences of hypertension and systolic blood pressure (SBP) values were higher in individuals with CAC (moderate CAC: 49.5%, 137.5 +/- 18.6 mmHg; severe CAC: 58.3%, 142.1 +/- 20.4 mmHg) compared to individuals with CAD but no CAC (42.0%, 134.0 +/- 18.4 mmHg; both P < 0.001). Likewise, pulse pressure was significantly elevated with increasing degree of CAC (no CAC, 52.3 +/- 13.6 mmHg vs moderate CAC, 55.7 +/- 14.4 mmHg vs severe CAC, 59.1 +/- 15.4 mmHg; P < 0.001). Further determinants of CAC were age, positive family history for CAC and severity of CAD. No differences in CAC severity were found in relation to body mass index, low-density lipoprotein-cholesterol, diabetes, and smoking habits. In multivariate analysis, CAC was independently related to age, SBP or pulse pressure, respectively, positive family history for CAC, and the severity of CAD.
  
  
  CONCLUSIONS
  Of the cardiovascular risk factors, SBP and pulse pressure display the strongest relationship with angiographic detection of CAC. Mechanistic studies need to clarify whether hypertension causes CAC, or whether coronary calcium deposition serves as a marker for a higher degree of vascular calcification and, thus, impaired vascular compliance and higher blood pressure levels.
authors.affiliation: Medizinische Klinik II, Universitätsklinik Schleswig Holstein, Campus Lübeck, Lübeck, Germany.
authors.forename: Björn
authors.initials: B
authors.lastname: Mayer
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lieb
authors.forename: Peter W
authors.initials: PW
authors.lastname: Radke
authors.forename: Anika
authors.initials: A
authors.lastname: Götz
authors.forename: Marcus
authors.initials: M
authors.lastname: Fischer
authors.forename: Andrea
authors.initials: A
authors.lastname: Bässler
authors.forename: Lars C
authors.initials: LC
authors.lastname: Doehring
authors.forename: Zouhair
authors.initials: Z
authors.lastname: Aherrahrou
authors.forename: Henrike
authors.initials: H
authors.lastname: Liptau
authors.forename: Jeanette
authors.initials: J
authors.lastname: Erdmann
authors.forename: Stephan
authors.initials: S
authors.lastname: Holmer
authors.forename: Hans-Werner
authors.initials: HW
authors.lastname: Hense
authors.forename: Christian
authors.initials: C
authors.lastname: Hengstenberg
authors.forename: Heribert
authors.initials: H
authors.lastname: Schunkert
mesh_terms: D001794:Blood Pressure; D002114:Calcinosis; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D015999:Multivariate Analysis; D010641:Phenotype; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires