[Difference between frequency of estrogen receptors distribution in the male and female rats myocardium].
The large number of reference data is proving the positive influence of exogenous hormones on the management of climacteric and dishormonal cardiomyopathies. However, the literary data concerning the influence of estrogens on the cardio-vascular system are quite controversial. For instance there is no certain opinion in the literature concerning influence of estrogens on the cardiovascular system of males, undergoing estrogen therapy due to prostate cancer. There has to be a correlation between functional condition of the heart and estrogens, that is why we do consider actual to study the distribution of estrogen receptors into the myocardium and their role in the rats heart defense in case of pituitrine and adrenaline influence. The experiments were carried out on the 40 white laboratory rats, both sexes, weighting 180-200 g. The radioactive moxestrol (spec. activity 87 c/mmol) has been administered intraperitoneally at 0, 25 mg/100g body weight to the experimental animals. The tissue pieces have been taken from the different areas of the heart (auricles and ventricles). The autoradiography both of normal and preconditioned by pituitrine and adrenaline tissue semi thin specimens has been performed. The tissue analysis has shown that total number of estrogen sensitive cells into myocardium in all areas of heart of the rats is persistently increasing in case of preconditioning by pituitrine and adrenaline comparing with intact animals. Analyzing increased number of estrogen sensitive cells in male and female rats, we suppose that during the critical condition of heart significant quantity of endogenous estrogen cells in females are used in heart auricles, and in contrary less - in ventricles. As to male rats the more quantity of endogenous estrogen is used in ventricles and less in auricles. Taking in account all of above mentioned we can conclude that estrogens certainly play a protective role in the heart of females.
Kakabadze
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D000818:Animals; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000032:analysis; D005260:Female; D008297:Male; D009206:Myocardium / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000032:analysis; D051381:Rats; D011960:Receptors, Estrogen / Q000032:analysis*; D012737:Sex Factors
D019275:Radiopharmaceuticals; D011960:Receptors, Estrogen; D004997:Ethinyl Estradiol; C011310:moxestrol