title: Antibacterial diterpenoids from Jatropha podagrica Hook.
abstract: Japodagrin (1) and japodagrone (2), two macrocylic diterpenoids possessing lathyrane and jatrophane skeletons, respectively, have been isolated from the root of Jatropha podagrica Hook. Four other diterpenoids (3-6) were also isolated from this plant. The structures of these compounds were elucidated on the basis of NMR and HRMS analysis, and by spectral comparisons. The compounds displayed antibacterial activity against some gram-positive bacteria.
authors.affiliation: Department of Chemistry, University of Ibadan, Ibadan, Nigeria. oaiyelaagbe@yahoo.com
authors.forename: Olapeju O
authors.initials: OO
authors.lastname: Aiyelaagbe
authors.forename: Kayode
authors.initials: K
authors.lastname: Adesogan
authors.forename: Olusegun
authors.initials: O
authors.lastname: Ekundayo
authors.forename: James B
authors.initials: JB
authors.lastname: Gloer
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031286:Jatropha / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes