title: Dengue hemorrhagic shock and disseminated candidiasis.
abstract: Dengue fever, one of the common endemic viral fevers, often presents with fever, rash, and mild liver dysfunction. However, plasma leakage induced by dengue virus infection can lead to dengue hemorrhagic fever and dengue shock syndrome, and it can cause severe complications including liver failure and encephalopathy. Infection of dengue virus with other pathogens is an unusual but serious complication. We report a case of dengue shock syndrome with liver failure and impaired consciousness. The patient developed a disseminated Candida tropicalis infection, which may have been due to translocation of the fungus from the intestine damaged by the dengue virus.
authors.affiliation: Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Kitazawa
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ota
authors.forename: Shu
authors.initials: S
authors.lastname: Okugawa
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Tsukada
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nukui
authors.forename: Shuji
authors.initials: S
authors.lastname: Hatakeyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamaguchi
authors.forename: Shinji
authors.initials: S
authors.lastname: Matsuse
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishii
authors.forename: Takehiro
authors.initials: T
authors.lastname: Matsubara
authors.forename: Chisako
authors.initials: C
authors.lastname: Yamauchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ota
authors.forename: Naoki
authors.initials: N
authors.lastname: Yahagi
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukayama
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Koike
mesh_terms: D001707:Biopsy, Needle; D001774:Blood Chemical Analysis; D002177:Candidiasis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D016469:Fungemia / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D017093:Liver Failure / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D019595:Severe Dengue / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D012720:Severity of Illness Index; D012771:Shock, Hemorrhagic / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed