Bioengineered alternative tissues and hyperbaric oxygen in lower extremity wound healing.
With the advent and clinical application of recombinant chemical and cellular mediators of wound healing and a better understanding of the importance of serial debridement, most foot wounds can be healed with little morbidity. Despite these advances, there remains the recalcitrant wound for which more heroic efforts seem warranted. For these patients, advanced wound healing technologies, orthobiologics, and bioengineered alternative tissues may tilt the scales in the direction of definitive wound closure.
Kim
Paul J
PJ
Foot and Ankle Institute, 918 Congress Avenue Ste 200, Austin, TX 78701, USA. pkimxx@midwestern.edu
Heilala
Matt
M
Steinberg
John S
JS
Weinraub
Glenn M
GM
D001684:Biological Dressings; D001698:Biomedical Engineering / Q000379:methods; D017719:Diabetic Foot / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D016879:Salvage Therapy / Q000379:methods; D017768:Skin, Artificial; D014945:Wound Healing / Q000502:physiology*