The primary cilium: keeper of the key to cell division.
Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.
Pan
Junmin
J
Department of Biological Sciences and Technologies, Tsinghua University, Haidian District, Beijing, 100084, China.
Snell
William
W
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D002502:Centrioles / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D018385:Centrosome / Q000378:metabolism* / Q000648:ultrastructure; D002923:Cilia / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D010770:Phosphotransferases / Q000235:genetics / Q000378:metabolism*; D008941:Spindle Apparatus / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure
D018797:Cell Cycle Proteins; D010770:Phosphotransferases