Analysis of antidiuretic effect of arginine-vasotocin and its analogs in primates.
Intramuscular injection of synthetic analogs of arginine-vasotocin to monkeys after 3% water loading caused antidiuretic reaction, manifesting by reabsorption of osmotically free water and paralleled by significant changes in excretion of sodium or potassium ions. It is shown that synthetic analogs can be more effective and selective than natural agonists.
Buravkova
L B
LB
Institute of Biomedical Problems, Russian Academy of Sciences, Moscow. buravkova@imbp.ru.
Larina
I M
IM
Korolkov
V I
VI
Dobrokhotov
I V
IV
Grigorev
A I
AI
D000818:Animals; D050034:Antidiuretic Agents / Q000494:pharmacology*; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology; D007477:Ions / Q000378:metabolism; D008253:Macaca mulatta / Q000502:physiology*; D008297:Male; D009994:Osmolar Concentration; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D014668:Vasotocin / Q000494:pharmacology*
D050034:Antidiuretic Agents; D004232:Diuretics; D007477:Ions; D001127:Arginine Vasopressin; D012964:Sodium; D011188:Potassium; D014668:Vasotocin