title: Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents.
abstract: Oxidative dimerization of ferulic acid methyl ester afforded dihydrobenzofuran derivative and new linear compound identified by X-ray crystallography. The gallate derivatized dihydrobenzofuran analogue was obtained and all compounds were evaluated for potential antiatherogenic, antiplasmodial (best IC(50)=0.8 microM) and cytotoxic activities.
authors.affiliation: Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique, LSPCMIB, UMR-CNRS 5068, Université Paul Sabatier, 118, Route de Narbonne, 31062 Toulouse Cedex 9, France.
authors.forename: D L A
authors.initials: DL
authors.lastname: Rakotondramanana
authors.forename: Mélanie
authors.initials: M
authors.lastname: Delomenède
authors.forename: Michel
authors.initials: M
authors.lastname: Baltas
authors.forename: Hubert
authors.initials: H
authors.lastname: Duran
authors.forename: Florence
authors.initials: F
authors.lastname: Bedos-Belval
authors.forename: Philippe
authors.initials: P
authors.lastname: Rasoanaivo
authors.forename: Anne
authors.initials: A
authors.lastname: Negre-Salvayre
authors.forename: Heinz
authors.initials: H
authors.lastname: Gornitzka
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D050197:Atherosclerosis / Q000188:drug therapy* / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects*; D003373:Coumaric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019281:Dimerization; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008077:Lipoproteins, LDL / Q000378:metabolism*; D051379:Mice; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D003373:Coumaric Acids; D004952:Esters; D008077:Lipoproteins, LDL; D017392:Thiobarbituric Acid Reactive Substances; C004999:ferulic acid