title: Long-term subjective continence status and use of alternative treatments by women with stress urinary incontinence after collagen injection therapy.
abstract: This study examined subjective continence status and use of subsequent alternative therapeutic procedures at long-term follow-up after collagen injection for stress incontinence (SI) in women. Seventy women who underwent collagen injection for SI were identified by retrospective chart review and surveyed by mail questionnaire for subjective continence status, daily pad usage pre- and post-treatment, and use of anticholinergics and alternative procedures. Questionnaire responders' versus non-responders' mean age, follow-up, and pad usage were compared. Thirty-three women (47%) responded on questionnaires. Of the 33, 50% were dry or subjectively improved at long-term follow-up and 91% had not chosen an alternative invasive treatment after collagen injection. Chart review showed responders were not significantly different from non-responders in mean age (65.9 vs. 69.2 years), pad usage (0.6 vs. 0.8 pads/day), or follow-up (4.5 vs. 4.3 years). Collagen injection, a minimally invasive treatment for SI, appears to benefit a significant number of women.
authors.affiliation: c/o Trisha Lane, Division of Urology, University of California San Diego Medical Center and Veterans Affairs Medical Center, 200 W. Arbor Drive, San Diego, CA, 92103-8897, USA. plane@ucsd.edu
authors.forename: Kyoko
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Sameer
authors.initials: S
authors.lastname: Sharma
authors.forename: John S
authors.initials: JS
authors.lastname: Wheeler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000008:administration & dosage*; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D003094:Collagen / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D017060:Patient Satisfaction; D011184:Postoperative Period; D019736:Prostheses and Implants; D019919:Prosthesis Implantation / Q000379:methods*; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D001743:Urinary Bladder; D014550:Urinary Incontinence, Stress / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery; D014563:Urodynamics / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D018680:Cholinergic Antagonists; C048470:glutaraldehyde-cross-linked collagen; D003094:Collagen