The -463G/A polymorphism in myeloperoxidase gene and cervical cancer.
BACKGROUND
Cervical cancer is the leading cause of cancer-related death in women in developing countries. The -463 type G polymorphism of the MPO gene has been correlated with higher MPO expression and increased risk of various types of cancers. Our study was performed in order to evaluate the association between the -463G polymorphism and the prevalence of cervical cancer.


METHODS
In our prospective study, 149 patients with cervical cancer and 126 patients without any malignancies were enrolled.


RESULTS
No significant difference was found between genotype distributions in the cervical cancer patients and the control group. There was also no significant association of the genotype distributions with clinical prognostic factors. However, significantly lower A allele frequency of the -463 polymorphism of the MPO gene was found in our study group in comparison with that of the average Caucasian population.


CONCLUSIONS
The -463 polymorphism of the MPO gene was not associated with susceptibility to cervical cancer.
Mustea
Alexander
A
Department of Gynaecology and Obstetrics, Charité, Campus Virchow-Klinikum, Medical University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. alexander.mustea@charite.de
Heinze
Georg
G
Sehouli
Jalid
J
Koensgen
Dominique
D
Wolf
Andrea
A
Gutu
Lilian
L
Sofroni
Dumitru
D
Pirvulescu
Cristina
C
Braicu
Elena Ioana
EI
Schuster
Eva
E
Zeillinger
Robert
R
Tong
Dan
D
D005260:Female; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D015995:Prevalence; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics*
D009195:Peroxidase