title: Production of optically active 1,2,4-butanetriol from corresponding racemate by Microbial stereoinversion.
abstract: Sterigmatomyces elviae DSM 70852 produced 12 g/l (S)-1,2,4-butanetriol (enantiomeric excess >99.9%) from 20 g/l racemate in 82 h. From the results of the inversion of an (R)-isomer to an (S)-isomer and GC-MS, it was suggested that (R)-1,2,4-butanetriol is oxidized to 1,4-dihydroxy-2-butanone, which is reduced to an (S)-isomer.
authors.affiliation: Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Japan. onoderak@bs.naist.jp
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamada-Onodera
authors.forename: Akihiro
authors.initials: A
authors.lastname: Norimoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Kawada
authors.forename: Rika
authors.initials: R
authors.lastname: Furuya
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Tani
mesh_terms: D000440:Butanols / Q000737:chemistry* / Q000302:isolation & purification*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000440:Butanols; C114589:1,3,4-butanetriol