New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).
Two 3-phenyldihydroisocoumarins (hydrangenol and phyllodulcin), a 3-phenylisocoumarin (thunberginol A), and a stilbene (hydrangeaic acid) from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium) promoted adipogenesis of 3T3-L1 cells. Hydrangenol, a principal constituent, significantly increased the amount of adiponectin released into the medium and mRNA levels of adiponectin, peroxisome proliferator-activated receptor gamma2 (PPARgamma2), and glucose transporter 4 (GLUT4), while it decreased the expression of interleukin 6 (IL-6) mRNA. Furthermore, hydrangenol significantly lowered blood glucose and free fatty acid levels 2 weeks after its administration at a dose of 200 mg/kg/d in KK-A(y) mice.
Zhang
Hailong
H
Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan.
Matsuda
Hisashi
H
Kumahara
Akira
A
Ito
Yuki
Y
Nakamura
Seikou
S
Yoshikawa
Masayuki
M
D041721:3T3-L1 Cells; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000378:metabolism; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D031966:Hydrangea / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D015850:Interleukin-6 / Q000378:metabolism; D049934:Isocoumarins / Q000494:pharmacology; D051379:Mice; D008956:Models, Chemical; D047495:PPAR gamma / Q000378:metabolism; D018515:Plant Leaves / Q000378:metabolism*
D005227:Fatty Acids; D051275:Glucose Transporter Type 4; D007004:Hypoglycemic Agents; D015850:Interleukin-6; D049934:Isocoumarins; D047495:PPAR gamma; C495692:SLC2A4 protein, human; C079055:thunberginol A; C008903:phyllodulcin