Paraneoplastic limbic encephalitis caused by ovarian teratoma with autoantibodies to glutamate receptor.
We report a rare case of paraneoplastic limbic encephalitis with autoantibodies to glutamate receptor (GluR) in the cerebrospinal fluid (CSF). The 35-year-old woman with consciousness disturbance was diagnosed initially as non-herpetic encephalitis. Her signs and symptoms improved with acyclovir and steroid pulse therapy. However, after the treatment, an ovarian tumor was discovered, and we detected autoantibodies to GluR in the CSF. A possible association between the ovarian teratoma and GluR is suggested.
Okamoto
Sadahisa
S
Department of Neurology, Graduate School of Medical Sciences, Kumamoto University. s-okamoto@fc.kumamoto-u.ac.jp
Hirano
Teruyuki
T
Takahashi
Yukitoshi
Y
Yamashita
Taro
T
Uyama
Eiichiro
E
Uchino
Makoto
M
D000328:Adult; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology*; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D020363:Limbic Encephalitis / Q000209:etiology* / Q000276:immunology; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy / Q000379:methods; D035583:Rare Diseases; D017470:Receptors, Glutamate / Q000276:immunology*; D018570:Risk Assessment; D013724:Teratoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
D001323:Autoantibodies; D017470:Receptors, Glutamate