title: [Contemporary molecular-biological methods of cancer diagnosis and monitoring based on the humoral immune response to tumor-associated antigens].
abstract: Humoral immune response to tumor-associated antigens in cancer patients can be used as a basis for disease diagnosis and monitoring. Moreover, identification of molecular targets of such response may be used to develop antigen-specific anticancer vaccines. Here, we review the main approaches to identification and study of tumor-associated antigens recognized by serum antibodies. We also focus on the challenges that must be met before serological antigens can be used in clinical cancer diagnostics.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Shebzukhov
authors.forename: P V
authors.initials: PV
authors.lastname: Belousov
authors.forename: S V
authors.initials: SV
authors.lastname: Khlgatian
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Sazykin
authors.forename: D V
authors.initials: DV
authors.lastname: Kuprash
authors.forename: S A
authors.initials: SA
authors.lastname: Nedospasov
mesh_terms: D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology*; D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D008991:Monitoring, Physiologic; D009369:Neoplasms / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm