title: Effects of Salvia officinalis L. extract on experimental acute inflammation.
abstract: The aim of this study was to investigate the effects of Salvia officinalis L. tincture on acute inflammation induced with oil of turpentine.
  
  
  METHODS
  Oil of turpentine (i.m. 0.6 ml/100 g b.w.) was injected into male Wistar rats right hind paw. Salviae folium tincture and diclofenac as positive control (30 mg/100 g b.w.) were administrated i.p. The effects were evaluated by measuring total leukocyte count and differential leukocyte count expressed as a percentage, a test of in vitro phagocytosis and evaluation of nitric oxide synthesis by measuring the metabolites: nitrites and nitrates.
  
  
  RESULTS
  Salvia officinalis tincture significantly reduced the total leukocyte and monocytes percentages and the activation of circulating phagocytes. NO synthesis had a slight decrease. Salvia officinalis tincture had a smaller inhibitory effect than diclofenac.
  
  
  CONCLUSIONS
  Salvia officinalis tincture had antiinflammatory effects by reducing marrow acute phase response and NO synthesis.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, "I. Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca.
authors.forename: Ilioara
authors.initials: I
authors.lastname: Oniga
authors.forename: Alina Elena
authors.initials: AE
authors.lastname: Pârvu
authors.forename: Anca
authors.initials: A
authors.lastname: Toiu
authors.forename: Daniela
authors.initials: D
authors.lastname: Benedec
mesh_terms: D000210:Acute-Phase Reaction; D000818:Animals; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D007509:Irritants / Q000009:adverse effects; D008297:Male; D023421:Models, Animal; D009569:Nitric Oxide / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027543:Salvia officinalis / Q000737:chemistry*; D014425:Turpentine / Q000009:adverse effects
chemical_list: D007509:Irritants; D010936:Plant Extracts; D009569:Nitric Oxide; D014425:Turpentine