Curcumin affects development of zebrafish embryo.
Embryotoxic and teratogenic effects of curcumin on the development of zebrafish embryo were investi-gated in this study. The LD(50) values of curcumin (24-h incubation) were estimated at 7.5 microM and 5 microM for embryos and larvae, respectively. The developmental defects caused by curcumin treatments include bent or hook-like tails, spinal column curving, edema in pericardial sac, retarded yolk sac resorption, and shorter body length. In curcumin-treated larvae, fluorescence signals of curcumin were found in edamae sac and some skin cells. Together, these results indicate that zebrafish are suitable model organisms to study the toxic effects of curcumin.
Wu
Jheng-Yu
JY
Department of Biology, National Changhua University of Education, Changhua, Taiwan, Republic of China.
Lin
Chin-Yi
CY
Lin
Tien-Wei
TW
Ken
Chuian-Fu
CF
Wen
Yu-Der
YD
D000014:Abnormalities, Drug-Induced; D000818:Animals; D003474:Curcumin / Q000493:pharmacokinetics / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004625:Embryo, Nonmammalian / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D007814:Larva / Q000187:drug effects / Q000378:metabolism; D007928:Lethal Dose 50; D015027:Zebrafish / Q000196:embryology*
D003474:Curcumin