title: Observer variation of 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography in mediastinal staging of non-small cell lung cancer as a function of experience, and its potential clinical impact.
abstract: OBJECTIVE
  To test the extent of variation among nuclear medicine physicians with respect to staging non-small cell lung cancer with positron emission tomography (PET).
  
  
  METHODS
  Two groups of nuclear medicine physicians with different levels of PET experience reviewed 30 PET scans. They were requested to identify and localize suspicious mediastinal lymph nodes (MLN) using standardized algorithms. Results were compared between the two groups, between individuals, and with expert reading.
  
  
  RESULTS
  Overall we found good interobserver agreement (kappa 0.65). Experience with PET translated into a better ability to localize MLN stations (68% vs. 51%, respectively), and experienced readers appeared to be more familiar with translating PET readings into clinically useful statements.
  
  
  CONCLUSIONS
  Although our results suggest that clinical experience with PET increases observers' ability to read and interpret results from PET adequately, there is room for improvement. Experience with PET does not necessarily improve the accuracy of image interpretation.
authors.affiliation: Department of Pulmonary Diseases, Catharina Hospital Eindhoven, Amsterdam, The Netherlands.
authors.forename: Sietske A
authors.initials: SA
authors.lastname: Smulders
authors.forename: Chad M
authors.initials: CM
authors.lastname: Gundy
authors.forename: Arthur
authors.initials: A
authors.lastname: van Lingen
authors.forename: Emile F
authors.initials: EF
authors.lastname: Comans
authors.forename: Frank W J M
authors.initials: FW
authors.lastname: Smeenk
authors.forename: Otto S
authors.initials: OS
authors.lastname: Hoekstra
mesh_terms: D000465:Algorithms; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000556:secondary*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary; D009367:Neoplasm Staging; D015588:Observer Variation; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18