Cyclooxygenase-2 immunoreactivity in equine ocular squamous-cell carcinoma.
Squamous-cell carcinoma (SCC) is the second most common tumor in horses, and 40%-50% may occur in ocular and adnexal structures. Cyclooxygenase (COX)-2 is an inducible enzyme responsible for the production of prostaglandins that control cell growth and the development and progression of cancer. Mechanisms responsible for the initial upregulation of COX-2 in neoplasia are unclear; prolonged sunlight exposure and mutations in the p53 gene may be possibilities. Because the etiopathogenesis of ocular SCC in horses may involve ultraviolet sunlight and p53 mutations, the purpose of this study was to characterize the immunoreactivity of COX-2 in these tumors. Cyclooxygenase-2 expression was found in 6 of 22 (27%) paraffin-embedded equine SCCs. Cyclooxygenase-2 immunoreactivity was associated with the mitotic index (P < 0.001). Strategies to inhibit COX-2 by the use of topical or systemic COX-2 inhibitors might prove to be a safe and economical treatment in some horses with SCC.
Rassnick
Kenneth M
KM
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA. kmr32@cornell.edu
Njaa
Bradley L
BL
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000276:immunology / Q000662:veterinary*; D051546:Cyclooxygenase 2 / Q000032:analysis* / Q000276:immunology; D005134:Eye Neoplasms / Q000201:enzymology / Q000276:immunology / Q000662:veterinary*; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006734:Horse Diseases / Q000201:enzymology* / Q000276:immunology; D006736:Horses
D051546:Cyclooxygenase 2