title: Thyroid-state influence on protein-expression profile of rat skeletal muscle.
abstract: We analyzed the whole-cell protein content of gastrocnemius muscles from rats in different thyroid states. Twenty differentially expressed proteins were unambiguously identified. They were involved in substrates and energy metabolism, stress response, cell structure, and gene expression. This study represents the first systematic identification of thyroid state-induced changes in the skeletal muscle protein-expression profile and reveals new cellular pathways as targets for thyroid hormone action.
authors.affiliation: Dipartimento di Scienze Biologiche ed Ambientali, Università degli Studi del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Silvestri
authors.forename: Lavinia
authors.initials: L
authors.lastname: Burrone
authors.forename: Pieter
authors.initials: P
authors.lastname: de Lange
authors.forename: Assunta
authors.initials: A
authors.lastname: Lombardi
authors.forename: Paola
authors.initials: P
authors.lastname: Farina
authors.forename: Angela
authors.initials: A
authors.lastname: Chambery
authors.forename: Augusto
authors.initials: A
authors.lastname: Parente
authors.forename: Antonia
authors.initials: A
authors.lastname: Lanni
authors.forename: Fernando
authors.initials: F
authors.lastname: Goglia
authors.forename: Maria
authors.initials: M
authors.lastname: Moreno
mesh_terms: D000818:Animals; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013963:Thyroid Hormones / Q000494:pharmacology
chemical_list: D009124:Muscle Proteins; D020543:Proteome; D012333:RNA, Messenger; D013963:Thyroid Hormones