title: Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men.
abstract: BACKGROUND
  Dietary alpha-linolenic acid (ALA) has been associated with reduced risk of development of atherosclerosis. Adiponectin is a hormone specifically secreted by adipocytes and considered to have anti-atherogenic properties.
  
  
  OBJECTIVE
  We examined the effect of increased dietary intake of ALA on plasma concentration of adiponectin.
  
  
  METHODS
  Thirty-five non-diabetic, dyslipidemic men, 38-71 years old, were randomly allocated to take either 15 ml of flaxseed oil rich in ALA (8.1 g/day; n = 18), or 15 ml of safflower oil per day, containing the equivalent n-6 fatty acid (11.2 g/day linoleic acid, LA; n = 17) (control group). The intervention period lasted for 12 weeks.
  
  
  RESULTS
  Plasma levels of adiponectin did not change after the increase in dietary intake of ALA in the flaxseed oil supplementation group, compared to the control group. No changes in body mass index, serum lipid concentrations, LDL density, or plasma TNF-alpha were found in the flaxseed oil versus the control group.
  
  
  CONCLUSIONS
  Dietary ALA has no effect on plasma adiponectin concentration in dyslipidemic men.
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: George K
authors.initials: GK
authors.lastname: Paschos
authors.forename: Antonis
authors.initials: A
authors.lastname: Zampelas
authors.forename: Demosthenes B
authors.initials: DB
authors.lastname: Panagiotakos
authors.forename: Stergios
authors.initials: S
authors.lastname: Katsiougiannis
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Griffin
authors.forename: Vasilios
authors.initials: V
authors.lastname: Votteas
authors.forename: Fotini N
authors.initials: FN
authors.lastname: Skopouli
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D019587:Dietary Supplements; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D008043:Linseed Oil / Q000008:administration & dosage* / Q000737:chemistry; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012450:Safflower Oil / Q000008:administration & dosage / Q000737:chemistry; D016896:Treatment Outcome; D017962:alpha-Linolenic Acid / Q000008:administration & dosage*
chemical_list: D052242:Adiponectin; D008055:Lipids; D017962:alpha-Linolenic Acid; D012450:Safflower Oil; D008043:Linseed Oil