title: Cardiovascular disease and anaphylaxis.
abstract: OBJECTIVE
  In severe anaphylaxis, the cardiovascular system is often heavily involved. Preexisting cardiovascular disease may therefore influence the course of anaphylaxis in a negative way.
  
  
  RESULTS
  Systemic mastocytosis and elevated baseline serum tryptase are associated with severe and fatal anaphylaxis to hymenoptera stings. This is due to an increased number of cardiac mast cells resulting in high concentrations of cardiotoxic mast cell mediators in cardiac tissue during anaphylaxis. Severe anaphylaxis in coronary heart disease, in particular, is explained by an increased load of cardiac mast cells together with coronary stenosis favouring myocardial hypoxia. Contraindications for the use of medications for cardiac disease in patients with anaphylaxis, especially beta-blockers, have been questioned by epidemiologic studies considering the positive effects of these drugs on much more prevalent cardiac diseases.
  
  
  CONCLUSIONS
  Preexisting cardiovascular disease, mastocytosis and elevated baseline serum tryptase are risk factors for fatal anaphylactic reactions or lasting morbidity due to myocardial or cerebrovascular infarction induced by anaphylaxis. Life-saving cardiac medications like beta-blockers may increase the severity of anaphylaxis. Since life-threatening cardiovascular diseases are much more frequent than anaphylaxis, the relative risk of either disease with and without these drugs must be analyzed carefully together with the cardiologist.
authors.affiliation: Department of Medicine, Zieglerspital, Bern, Switzerland. ulrich.mueller@spitalnetzbern.ch
authors.forename: Ulrich R
authors.initials: UR
authors.lastname: Mueller
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D000707:Anaphylaxis / Q000150:complications* / Q000628:therapy; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D001180:Arthropod Venoms / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D002318:Cardiovascular Diseases / Q000150:complications* / Q000188:drug therapy; D003888:Desensitization, Immunologic; D004837:Epinephrine / Q000008:administration & dosage; D006801:Humans; D007299:Insect Bites and Stings / Q000150:complications*; D008297:Male; D008415:Mastocytosis / Q000150:complications*; D008875:Middle Aged; D053802:Tryptases / Q000097:blood*
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D001180:Arthropod Venoms; D053802:Tryptases; D004837:Epinephrine