Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells.
Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.
Yoon
Hoon-Seok
HS
Technology Innovation Center for Life Science, Cheju National University, Jeju, Korea.
Lee
Sun-Ryung
SR
Ko
Hee-Chul
HC
Choi
Soo-Youn
SY
Park
Ji-Gweon
JG
Kim
Jeong-Kook
JK
Kim
Se-Jae
SJ
D000818:Animals; D045744:Cell Line, Tumor; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology*; D047309:Flavones / Q000502:physiology*; D005419:Flavonoids / Q000502:physiology*; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000201:enzymology* / Q000209:etiology; D051379:Mice; D014442:Monophenol Monooxygenase / Q000502:physiology
D047309:Flavones; D005419:Flavonoids; D008543:Melanins; C008661:nobiletin; D014442:Monophenol Monooxygenase; D048049:Extracellular Signal-Regulated MAP Kinases