title: Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum.
abstract: Lysyl tRNA synthetases facilitate amino acylation and play a crucial role in the essential cellular process of translation. They are grouped into two distinct classes (class I and class II). Class I lysyl tRNA synthetase is considered as a drug target for syphilis caused by Treponema pallidum. Comparative genome analysis shows the absence of its sequence homolog in eukaryotes. The structure of class I lysyl tRNA synthetase from Treponema pallidum is unknown and the difficulties in the in vitro culturing of Treponema makes it non-trivial. We used the structural template of class I lysyl tRNA synthetase from the archaea Pyrococcus horikoshii for modeling the Treponema pallidum lysyl tRNA synthetase structure. Thus, we propose the usefulness of the modeled class I lysyl tRNA synthetase for the design of suitable inhibitors towards the treatment of syphilis.
authors.affiliation: Department of Microbiology, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India.
authors.forename: Venkata Rao Dodaghatta Krishna
authors.initials: VR
authors.lastname: Rao
authors.forename: Rallapalli
authors.initials: R
authors.lastname: Ramanjeneyulu
authors.forename: Dowlathabad Muralidhara
authors.initials: DM
authors.lastname: Rao
authors.forename: Chitta Suresh
authors.initials: CS
authors.lastname: Kumar