Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease.
Controversy exists as to whether the deletion/deletion (DD) genotype of angiotensin l-converting enzyme (ACE) gene polymorphism is associated with coronary heart disease (CHD). There are only a few studies dealing with this issue in the elderly, also with controversial results. The aim of this study was the assessment of correlation between genetic markers and the risk of CHD in the elderly. The results indicated DD genotype importance for CHD in the elderly as proven by discriminant analysis (chi2 = 25.77; df = 16; p = 0.0620). However, the use of univariate method demonstrated no correlation between DD genotype of ACE gene polymorphism and coronary artery disease. D allele of ACE gene was associated with higher activities of ACE plasma. A weak, but increased risk of MI is associated with high frequency of DD genotype in the elderly. Strong correlation between ACE polymorphism and ACE plasma activities was demonstrated.
Marković
Biserka Bergman
BB
Department of Family Medicine, Andrija Stampar School of Public Health, School of Medicine, University of Zagreb, Zagreb, Croatia. bbmarkovic@yahoo.co.uk
Bergovec
Mijo
M
Reiner
Zeljko
Z
Sertić
Jadranka
J
Vincelj
Josip
J
Marković
Maja
M
D000368:Aged; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A