[Obesity surgery in patients suffering from monogenetic adipositas].
Surgical treatment of patients suffering from monogenetic forms of morbid obesity is considered to be the poorest investigated theme in bariatric surgery. This review article presents aspects of genetic disorders in morbid obesity as well as some aspects of surgical treatment in patients with monogenetic forms of morbid obesity (Prader-Willi-Syndrome). Gastric restrictive procedures such as vertical banded gastroplasty or adjustable gastric banding as well as malabsorptive and mix procedures such as biliopancreatic diversion or Roux-en-Y gastric bypass are used for treatment, similar to polygenetic forms of morbid obesity. Until to now there is no evidence-based data because of the small number of published cases. Decisions about the indication to operation and about the choice of surgical procedures are based on the empiric fundament. It is to suggest that the use of growth hormones in patients with monogenetic forms of morbid obesity could positively influence the results of bariatric surgery in these patients.
Korenkov
M
M
Klinik und Poliklinik für Allgemein- und Abdominalchirurgie, Johannes-Gutenberg-Universität Mainz. korenkov@ach.klinik.uni-mainz.de
Kohlschmidt
N
N
Zechner
U
U
Haaf
T
T
Junginger
T
T
D000293:Adolescent; D000328:Adult; D050110:Bariatric Surgery / Q000379:methods*; D015904:Biliopancreatic Diversion; D005500:Follow-Up Studies; D015390:Gastric Bypass; D015391:Gastroplasty; D006801:Humans; D008875:Middle Aged; D020412:Multifactorial Inheritance / Q000235:genetics; D009767:Obesity, Morbid / Q000235:genetics* / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology; D011218:Prader-Willi Syndrome / Q000235:genetics / Q000601:surgery; D015431:Weight Loss