title: Transarterial embolization of giant liver hemangiomas associated with Kasabach-Merritt syndrome: a case report.
abstract: Of 22 patients with symptomatic giant liver hemangiomas referred for embolization, two females (52 and 74 years) had Kasabach-Merritt syndrome (KMS). Hematocrit values were observed to be 33% and 29%, platelets 4000 and 5400/mm(3), and fibrinogen 98 and 77 mg/dl, respectively. Lesion diameters were 7 and 14 cm, respectively. Hepatic angiography revealed excessive vascular lakes typical of cavernous hemangiomas. Microspheres of 40-300 microm were superselectively injected under fluoroscopic guidance until cessation of flow. Coil packing of the feeding hepatic artery was additionally used in one patient. The procedure was uneventful in both. Partial restoration of platelet count was observed immediately; fibrinogen levels and platelets were restored completely in one patient and partially in the other, without remissions at 2-year follow-up.
authors.affiliation: Second Department of Radiology, Medical School, University of Athens, Greece. kmalag@acn.gr
authors.forename: K
authors.initials: K
authors.lastname: Malagari
authors.forename: E
authors.initials: E
authors.lastname: Alexopoulou
authors.forename: S
authors.initials: S
authors.lastname: Dourakis
authors.forename: A
authors.initials: A
authors.lastname: Kelekis
authors.forename: K
authors.initials: K
authors.lastname: Hatzimichail
authors.forename: A
authors.initials: A
authors.lastname: Sissopoulos
authors.forename: S
authors.initials: S
authors.lastname: Delis
authors.forename: D
authors.initials: D
authors.lastname: Letsou
authors.forename: D
authors.initials: D
authors.lastname: Kelekis
mesh_terms: D000368:Aged; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D005340:Fibrinogen; D005500:Follow-Up Studies; D006391:Hemangioma / Q000150:complications* / Q000628:therapy*; D006400:Hematocrit / Q000379:methods; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000628:therapy*; D008863:Microspheres; D008875:Middle Aged; D010976:Platelet Count; D035583:Rare Diseases; D013577:Syndrome; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005340:Fibrinogen