title: Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation.
abstract: We report a case of small cell lung cancer (SCLC) developing after prolonged treatment (more than 2 years) for primary adenocarcinoma of the lung, and we show that both the SCLC and non-small cell lung cancer (NSCLC) tissues obtained from the same site share the same deletion in exon 19 of EGFR. This case suggests that the activating EGFR mutations may confer the pathogenesis of a subset of SCLC.
authors.affiliation: Department of Medical Oncology, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan.
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Morinaga
authors.forename: Isamu
authors.initials: I
authors.lastname: Okamoto
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Furuta
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kawano
authors.forename: Masaru
authors.initials: M
authors.lastname: Sekijima
authors.forename: Kensaku
authors.initials: K
authors.lastname: Dote
authors.forename: Takao
authors.initials: T
authors.lastname: Satou
authors.forename: Kazuto
authors.initials: K
authors.lastname: Nishio
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fukuoka
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakagawa
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000473:pathology*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D066246:ErbB Receptors