title: [Effect of various uses of propofol on the upper gastrointestinal endoscopy].
abstract: OBJECTIVE
  To investigate the efficacy and security of different uses of propofol on the sedation during the upper gastrointestinal endoscopic procedures.
  
  
  METHODS
  Four hundred patients who underwent gastroscopy received midazolam and propofol as sedation. Patients were divided to 4 groups with different intervals between midazolam and propofol: Group A and D with the interval of 30 seconds to 1 minute, Group B and C with 3 to 5 minute interval. All patients were premedicated with midazolam and propofol at 16 approximately 25 mg/10s (Group A and B) and 6 approximately 7 mg/10s (Group C and D).
  
  
  RESULTS
  The doses of propofol of Group A,B,C, and D were (111.90+/-22.43),(102.20+/-15.99),(73.05+/-13.08) and (80.90+/-17.36)mg respectively, with significant difference(P<0.01). The time of return to consciousness decreased markedly in Group C and D [(9+/-1), (10+/-2)min ], and that of Group A and B was [(14+/-5), (13+/-3)min ]. There was significant difference between Group C, D and Group A, B(P<0.01).
  
  
  CONCLUSIONS
  The dose of propofol and the time of return to consciousness depend on the rate of administration and the interval between midazolam and propofol. Appropriate rate and interval can produce safer and more effective sedation for the upper gastrointestinal endoscopic procedure.
authors.affiliation: Department of Gastroenterology, Third Xiangya Hospital, Central South University,Changsha 410013, China.
authors.forename: Ding-hua
authors.initials: DH
authors.lastname: Xiao
authors.forename: Shou-rong
authors.initials: SR
authors.lastname: Shen
authors.forename: Can-xia
authors.initials: CX
authors.lastname: Xu
authors.forename: Wu-liang
authors.initials: WL
authors.lastname: Tang
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Wang
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004305:Dose-Response Relationship, Drug; D016145:Endoscopy, Digestive System / Q000379:methods*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam; D015742:Propofol