title: Efficacy of low-density lipoprotein apheresis in arteriosclerosis obliterans of the lower extremities: two cases with marked alleviation of clinical symptoms.
abstract: We have recognized marked effectiveness for intermittent claudication with low-density lipoprotein (LDL) apheresis in two cases of arteriosclerosis obliterans (ASO). The Case 1 was a 73-year-old man with intermittent claudication of both lower extremities (Fontaine class II), digital subtraction angiography (DSA) revealed complete obstruction of the left common iliac artery, formation of a collateral to the peripheral portion of the left common iliac artery, and diffuse stenosis of the peripheral portion of the right common iliac artery. Ten sessions of LDL apheresis (LDL-A) improved the walking distance from 100 m before to 600 m after LDL-A treatment. The Case 2 was a 61-year-old man with intermittent claudication of the left lower extremity (walking distance: 200 m) began at 59 years. DSA revealed diffuse stenosis of the peripheral portion of the left popliteal artery. Ten sessions of LDL-A improved the walking distance from 200 m before to 800 m after LDL-A. At one month after the end of LDL-A treatment, DSA revealed formation of collateral to the peripheral portion of the left popliteal artery. Our findings suggest that LDL-A combined with drug treatment is safe and useful for the treatment of ASO, especially walking distance improved with short term treatment.
authors.affiliation: Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan. rody-tkm@sd.dcns.ne.jp
authors.forename: Toshihide
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sato
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Niizuma
authors.forename: Toshio
authors.initials: T
authors.lastname: Kushiro
authors.forename: Shigemasa
authors.initials: S
authors.lastname: Tani
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Nagao
authors.initials: N
authors.lastname: Kajiwara
authors.forename: Katsuo
authors.initials: K
authors.lastname: Kanmatsuse
authors.forename: Hironori
authors.initials: H
authors.lastname: Ikeda
authors.forename: Motoichirou
authors.initials: M
authors.lastname: Takahashi
authors.forename: Shunichi
authors.initials: S
authors.lastname: Kojima
mesh_terms: D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000628:therapy*; D001781:Blood Component Removal; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood*; D035002:Lower Extremity / Q000098:blood supply / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D008077:Lipoproteins, LDL