title: [Total pelvic exenteration in the treatment of advanced pelvic cancer].
abstract: Total pelvic exenteration (TPE) is a radical and aggressive procedure performed in the local advanced pelvic cancer started from any pelvic organ. The experience of 73 TPE performed for local invasive cancer and centro-pelvic recurrences with initial malignancy at the cervix (45 cases), rectum (19 cases), vagina (5 cases), endometrial (3 cases) and urinary bladder (1 case), in 61 females and 12 males with age range 27-78 years, are analysed. The procedures were performed for advanced pelvic cancer in 24 cases and also for invasive centro-pelvic recurrences in 49 cases (67.5%). In 5 cases, TPE was extended laterally. In 42 patients reconstructive procedures were added. All patients survived to surgery but 5 postoperative deaths (6.8%) were recorded. Complications occurred in 52% of cases, 38 from 73 patients had one or more than one complication with an average of 1.5 per patient. 22 among these patients (30%) requiring operative treatment. The average survival was 49.07 months, the median survival of 55 months and the estimated survival at 11 and 78 months was 66%, respectively 50%. The procedure is indicated in the absence of pelvic wall invasion and secondary distant dissemination and lengthens significantly the life span and increase the quality of life.
authors.affiliation: Centrul de Chirurgie Generală şi Transplant Hepatic, Institutul Clinic Fundeni, Bucureşti. gmitulescu@gmail.com
authors.forename: G
authors.initials: G
authors.lastname: Mitulescu
authors.forename: C
authors.initials: C
authors.lastname: Ungureanu
authors.forename: G
authors.initials: G
authors.lastname: Gluck
authors.forename: C
authors.initials: C
authors.lastname: Stîngu
authors.forename: D
authors.initials: D
authors.lastname: Mitulescu
authors.forename: D
authors.initials: D
authors.lastname: Stănculeanu
authors.forename: O
authors.initials: O
authors.lastname: Sgarbură
authors.forename: D
authors.initials: D
authors.lastname: Tulbure
authors.forename: I
authors.initials: I
authors.lastname: Popescu
mesh_terms: D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010385:Pelvic Exenteration / Q000009:adverse effects; D010386:Pelvic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000601:surgery; D012189:Retrospective Studies; D012383:Romania; D016019:Survival Analysis; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000601:surgery; D014547:Urinary Diversion; D002583:Uterine Cervical Neoplasms / Q000601:surgery; D014625:Vaginal Neoplasms / Q000601:surgery