title: Light and darkness fail to regulate melatonin release in critically ill humans.
abstract: OBJECTIVE
  Pineal dysfunction has been associated with morbidity and mortality in various animal models of severe illness, and low melatonin plasma concentrations have recently been reported in patients on the ICU. However, it is not known whether the physiological response of the pineal gland to light and darkness is preserved in critical illness.
  
  
  METHODS
  We examined the nocturnal release of melatonin in response to 1 h of darkness followed by 1 h of bright light (>10,000 lux) in 20 severely ill patients on a medical ICU. Eleven elderly (median age 73 years) and 9 young patients (38 years) were recruited. Melatonin plasma concentrations were measured at 30-min intervals.
  
  
  RESULTS
  In 15 patients melatonin plasma concentration was low and responded to neither darkness nor light. In three elderly and two young patients melatonin plasma concentrations were elevated irrespective of illumination.
  
  
  CONCLUSIONS
  The physiological regulation of melatonin secretion by darkness and light is abolished in severely ill patients.
authors.affiliation: Department of Internal Medicine I, University of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Perras@kfg.mu-luebeck.de
authors.forename: Boris
authors.initials: B
authors.lastname: Perras
authors.forename: Markus
authors.initials: M
authors.lastname: Meier
authors.forename: Christoph
authors.initials: C
authors.lastname: Dodt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016638:Critical Illness; D003624:Darkness; D005260:Female; D005858:Germany; D006801:Humans; D007362:Intensive Care Units; D008027:Light; D008297:Male; D008550:Melatonin / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D008550:Melatonin