title: Synthesis and antibacterial activity of bis[2-amino-4-phenyl-5-thiazolyl] disulfides.
abstract: Different dimeric disulfides, having the basic skeleton of bis[2-amino-4-phenyl-5-thiazolyl] disulfides were synthesized in a straightforward manner from acetophenones. 2-Amino-4-phenyl-1,3-thiazoles were prepared by the reaction of thiourea with substituted acetophenones in the presence of iodine which were then converted to the title compounds. All the compounds were subjected to preliminary evaluation for their biological activity against Gram positive and Gram negative bacteria. Some of the assayed compounds showed marked activity against Bacillus cereus and Pseudomonas aeruginosa.
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
authors.forename: Hamid Latif
authors.initials: HL
authors.lastname: Siddiqui
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zia-Ur-Rehman
authors.forename: Naveed
authors.initials: N
authors.lastname: Ahmad
authors.forename: George William
authors.initials: GW
authors.lastname: Weaver
authors.forename: Paul David
authors.initials: PD
authors.lastname: Lucas
mesh_terms: D000098:Acetophenones / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004220:Disulfides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000098:Acetophenones; D000900:Anti-Bacterial Agents; D004220:Disulfides; D013844:Thiazoles