title: Nerve conduction study of healthy Asian Malays: the influence of age on median, ulnar, and sural nerves.
abstract: BACKGROUND
  Nerve conduction study is essential in the diagnosis of focal neuropathies and diffuse polyneuropathies. There are many factors that can affect nerve conduction velocity, and age is one of them. Most of the many studies of this effect, and the values from them, were on Caucasian subjects. Therefore, this study was designed to investigate the effect of age on conduction velocity among healthy Asian Malay subjects by analyzing its influence on the median, ulnar, and sural nerves.
  
  
  METHODS
  A total of 250 healthy subjects were recruited. The subjects were divided into four age groups. The nerves tested were the median, ulnar, and sural nerves. Surface electrodes were used and the temperature was kept constant. The nerves were stimulated and recorded at specific sites both for motor and sensory conduction velocities.
  
  
  RESULTS
  The mean velocities for the median and ulnar nerves, both motor and sensory, were 54.71+/-5.69 m/s (motor) and 54.04+/-7.02 m/s for the median nerve and 60.57+/-5.00 m/s (motor) and 52.92+/-5.89 m/s for the ulnar nerve. The mean velocity for the sural nerve was 47.97+/-4.48 m/s. Only median motor conduction velocity showed a significant reduction with increasing age (p=0.000).
  
  
  CONCLUSIONS
  This study did not show any significant effect of age on nerve conduction velocities except for median motor conduction velocity. For future research it is planned to extend the recruitment to subjects who are much older (over 60 years of age) and study the effect of other personal factors such as height and body mass index on NCV.
authors.affiliation: Department of Neurosciences, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Malaysia. saufiawang@yahoo.com
authors.forename: Mohamed Saufi
authors.initials: MS
authors.lastname: Awang
authors.forename: Jafri Malin
authors.initials: JM
authors.lastname: Abdullah
authors.forename: Mohd Rusli
authors.initials: MR
authors.lastname: Abdullah
authors.forename: Adnan
authors.initials: A
authors.lastname: Tahir
authors.forename: John
authors.initials: J
authors.lastname: Tharakan
authors.forename: Atul
authors.initials: A
authors.lastname: Prasad
authors.forename: Salmi Abdul
authors.initials: SA
authors.lastname: Razak
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008296:Malaysia; D008297:Male; D008475:Median Nerve / Q000378:metabolism; D008875:Middle Aged; D009046:Motor Neurons / Q000378:metabolism; D009420:Nervous System; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000473:pathology; D009431:Neural Conduction / Q000502:physiology*; D009475:Neurons, Afferent / Q000378:metabolism; D010525:Peripheral Nerves / Q000502:physiology*; D012016:Reference Values; D013497:Sural Nerve / Q000378:metabolism; D014459:Ulnar Nerve / Q000378:metabolism