title: Anti-citrullinated antibodies, radiological joint damages and their correlations with disease activity score (DAS28).
abstract: Determination of anti-citrullinated peptides (anti-CCP) specificity as a predictor of joint erosive changes, correlation between their serum level and radiological damages as well as disease activity score (DAS28). A trial has been conducted on a 211 patient sample fulfilling ACR criteria for rheumatoid arthritis (RA). There was assigned anti-CCP serum level, disease activity score by the formula for DAS28(3)-CRP and assessed radiological changes degree after Steinbrocker score. In 132 patient (62.559%) the serum anti-CCP concentration was positive for RA. Specificity of the test was 100% and sensitivity 65% (Z = 0.731, p = 0.465). There is a medium intensity correlation between variables representing anti-CCP and Steinbrocker score. Pearson's coefficient was 0.479 and Spearman's rank correlation coefficient was 0.614, i.e. statistically significant (p = 0.000). There is no statistically significant correlation between variables representing anti-CCP and DAS28(3)-CRP Anti-CCP are good RA predictor and their concentration correlate with radiological damages degree.
authors.affiliation: Department of Internal Medicine, School of Medicine, University of J. J. Strossmayer, Osijek, Croatia. glasnovic.marija@kbo.hr
authors.forename: Marija
authors.initials: M
authors.lastname: Glasnović
authors.forename: Ivica
authors.initials: I
authors.lastname: Bosnjak
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Vcev
authors.forename: Ivan
authors.initials: I
authors.lastname: Soldo
authors.forename: Elizabeta
authors.initials: E
authors.lastname: Glasnović-Horvatić
authors.forename: Silva
authors.initials: S
authors.lastname: Soldo-Butković
authors.forename: Jasna
authors.initials: J
authors.lastname: Pavela
authors.forename: Nikola
authors.initials: N
authors.lastname: Mićunović
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000276:immunology; D001175:Arthrography; D001323:Autoantibodies / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D002097:C-Reactive Protein