Abnormally expanded pro-B hematogones associated with congenital cytomegalovirus infection.
Hematogones are nonleukemic immature lymphocytes that display a B-precursor phenotype and populate the pediatric bone marrow. We present the case of a newborn with an atypical, marked expansion of hematogones similar to the pro-B cells of infant acute lymphoblastic leukemia, which demonstrated their nonleukemic nature through gene rearrangement analysis and were associated with a congenital cytomegalovirus infection.
Intermesoli
Tamara
T
USC Ematologia, Ospedali Riuniti, Bergamo, Italy. tintermesoli@ospedaliriuniti.bergamo.it
Mangili
Giovanna
G
Salvi
Anna
A
Biondi
Andrea
A
Bassan
Renato
R
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000175:diagnosis* / Q000188:drug therapy / Q000635:transmission; D003937:Diagnosis, Differential; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D006525:Hepatitis, Viral, Human / Q000151:congenital / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D018445:Infectious Disease Transmission, Vertical; D016031:Liver Transplantation; D016131:Lymphocyte Subsets / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis
D000998:Antiviral Agents; D015774:Ganciclovir