title: Evaluation of a muscle relaxant on sequelae of third molar surgery: a pilot study.
abstract: OBJECTIVE
  The aim of this preliminary study was to evaluate the influence of the muscle relaxant tizanidine following third molar surgery on the main variables trismus and pain as well as on swelling.
  
  
  METHODS
  Fifty healthy patients participated in this prospective clinical study. The test group received tizanidine (4 mg in the evenings for the first 2 postoperative days) in addition to antibiotic and antiinflammatory medications. Postoperatively, 1 independent investigator performed clinical examinations. Appropriate statistical analysis was used to evaluate data.
  
  
  RESULTS
  There was no statistically significant difference in facial pain and swelling between the two groups. Statistically significant improvement was detected when the groups were compared for mouth opening ability at days one and three.
  
  
  CONCLUSIONS
  The results of this trial indicate that the influence of tizanidine on trismus, pain, and swelling does not justify prescription of the additional medication.
authors.affiliation: Department of Oral Surgery and Radiology, School of Dental Medicine, Medical University of Graz, Graz, Austria. robert.kirmeier@meduni-graz.at
authors.forename: Robert
authors.initials: R
authors.lastname: Kirmeier
authors.forename: Astrid
authors.initials: A
authors.lastname: Truschnegg
authors.forename: Michael
authors.initials: M
authors.lastname: Payer
authors.forename: Stephan
authors.initials: S
authors.lastname: Acham
authors.forename: Karin
authors.initials: K
authors.lastname: Schulz
authors.forename: Norbert
authors.initials: N
authors.lastname: Jakse
mesh_terms: D000293:Adolescent; D000328:Adult; D003000:Clonidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery*; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D017678:Sex Distribution; D014313:Trismus / Q000188:drug therapy*
chemical_list: D009125:Muscle Relaxants, Central; C023754:tizanidine; D003000:Clonidine