Effects of retinoic acid on ischemic brain injury-induced neurogenesis.
Neurogenesis can be induced by pathological conditions such as cerebral ischemia. However the molecular mechanisms or modulating reagents of the reactive neurogenesis after the cerebral ischemia are poorly characterized. Retinoic acid (RA) has been shown to increase neurogenesis by enhancing the proliferation and neuronal differentiation of forebrain neuroblasts. Here, we examined whether RA can modulate the reactive neurogenesis after the cerebral ischemia. In contrast to our expectation, RA treatment decreased the reactive neurogenesis in subventricular zone (SVZ), subgranular zone (SGZ) and penumbral region. Furthermore, RA treatment also decreased the angiogenesis and gliosis in penumbral region.
Jung
Dae-Soo
DS
Department of Neurology, School of Medicine, Pusan National University, Busan 602-739, Korea.
Baek
Sun-Yong
SY
Park
Kyu-Hyun
KH
Chung
Young-In
YI
Kim
Hak-Jin
HJ
Kim
Chi-Dae
CD
Cho
Min-Kyoung
MK
Han
Myoung-Eun
ME
Park
Kyung-Pil
KP
Kim
Bong-Seon
BS
Kim
Jae-Bong
JB
Oh
Sae-Ock
SO
D000818:Animals; D001921:Brain / Q000098:blood supply; D002454:Cell Differentiation; D049109:Cell Proliferation; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009389:Neovascularization, Pathologic; D009457:Neuroglia / Q000473:pathology / Q000502:physiology; D009474:Neurons / Q000473:pathology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014212:Tretinoin / Q000494:pharmacology* / Q000502:physiology
D014212:Tretinoin