title: Preoperative exercise Vo2 measurement for lung resection candidates: results of Cancer and Leukemia Group B Protocol 9238.
abstract: BACKGROUND
  A stepwise approach to the functional assessment of lung resection candidates is widely accepted, and this approach incorporates the measurement of exercise peak Vo2 when spirometry and radionuclear studies suggest medical inoperability. A new functional operability (FO) algorithm incorporates peak exercise Vo2 earlier in the preoperative assessment to determine which patients require preoperative radionuclear studies. This algorithm has not been studied in a multicenter study.
  
  
  METHODS
  The CALGB (Cancer and Leukemia Group B) performed a prospective multi-institutional study to investigate the use of primary exercise Vo2 measurement for the prediction of surgical risk. Patients with known or suspected resectable non-small cell lung cancer (NSCLC) were eligible. Exercise testing including measurement of peak oxygen uptake (Vo2), spirometry, and single breath diffusion capacity (DLCO) was performed on each patient. Nuclear perfusion scans were obtained on selected high-risk patients. After surgery, morbidity and mortality data were collected and correlated with preoperative data. Mortality and morbidity were retrospectively compared by algorithm-based risk groups.
  
  
  RESULTS
  Three hundred forty-six patients with suspected lung cancer from nine institutions underwent thoracotomy with or without resection; 57 study patients did not undergo thoracotomy. Patients who underwent surgery had a median survival time of 30.9 months, whereas patients who did not undergo surgery had a median survival time of 15.6 months. Among the 346 patients who underwent thoracotomy, 15 patients died postoperatively (4%), and 138 patients (39%) exhibited at least one cardiorespiratory complication postoperatively. We found that patients who had a peak exercise Vo2 of <65% of predicted (or a peak Vo2/kg <16 ml/min/kg) were more likely to suffer complications (p = 0.0001) and were also more likely to have a poor outcome (respiratory failure or death) if the peak Vo2 was <15 ml/min/kg (p = 0.0356). We also found a subset of 58 patients who did not meet FO algorithm criteria for operability, but who still tolerated lung resection with a 2% mortality rate.
  
  
  CONCLUSIONS
  Our data provide multicenter validation for the use of exercise Vo2 for preoperative assessment of lung cancer patients, and we encourage an aggressive approach when evaluating these patients for surgery.
authors.affiliation: Roswell Park Cancer Institute, Buffalo, New York 14263, USA. gregory.loewen@roswellpark.org
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Loewen
authors.forename: Dorothy
authors.initials: D
authors.lastname: Watson
authors.forename: Leslie
authors.initials: L
authors.lastname: Kohman
authors.forename: James E
authors.initials: JE
authors.lastname: Herndon
authors.forename: Hani
authors.initials: H
authors.lastname: Shennib
authors.forename: Kemp
authors.initials: K
authors.lastname: Kernstine
authors.forename: Jemi
authors.initials: J
authors.lastname: Olak
authors.forename: M Jeffery
authors.initials: MJ
authors.lastname: Mador
authors.forename: David
authors.initials: D
authors.lastname: Harpole
authors.forename: David
authors.initials: D
authors.lastname: Sugarbaker
authors.forename: Mark
authors.initials: M
authors.lastname: Green
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007938:Leukemia; D008175:Lung Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D010101:Oxygen Consumption / Q000502:physiology*; D011013:Pneumonectomy; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D013147:Spirometry; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology