The management of fistulizing oral Crohn's disease with infliximab.
A 20-year-old female patient with oral Crohn's disease developed a fistula in her neck from a focus of intra-oral infection. Despite repeated courses of antimicrobial therapy over a period of several months, the fistula failed to resolve. However, following administration of infliximab, a monoclonal antitumour necrosis factor-alpha antibody, the fistula resolved spontaneously without the need for any further treatment.
Staines
K S
KS
Department of Oral Medicine, Newcastle Dental Hospital, Newcastle Upon Tyne, UK. konrad.staines@nutyh.nhs.uk
Green
R
R
Felix
D H
DH
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D017577:Cutaneous Fistula / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D000069285:Infliximab; D009059:Mouth Diseases / Q000150:complications / Q000188:drug therapy*; D016155:Oral Fistula / Q000188:drug therapy* / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab