title: Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration.
abstract: We applied optimised voxel based morphometry (VBM) to brain MRIs from autopsy proven cases of tau positive frontotemporal lobar degeneration (FTLD-T, n = 6), ubiquitin and TDP-43 positive/tau negative FTLD (FTLD-U, n = 8) and cognitively normal controls (n = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo.
authors.affiliation: Memory and Aging Center, and Department of Neurology, University of California, San Francisco, San Francisco, California 94117, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Kim
authors.forename: G D
authors.initials: GD
authors.lastname: Rabinovici
authors.forename: W W
authors.initials: WW
authors.lastname: Seeley
authors.forename: C
authors.initials: C
authors.lastname: Halabi
authors.forename: H
authors.initials: H
authors.lastname: Shu
authors.forename: M W
authors.initials: MW
authors.lastname: Weiner
authors.forename: S J
authors.initials: SJ
authors.lastname: DeArmond
authors.forename: J Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: M L
authors.initials: ML
authors.lastname: Gorno-Tempini
authors.forename: B L
authors.initials: BL
authors.lastname: Miller
authors.forename: H J
authors.initials: HJ
authors.lastname: Rosen
mesh_terms: D000368:Aged; D001284:Atrophy / Q000473:pathology; D001344:Autopsy; D002421:Caudate Nucleus / Q000033:anatomy & histology; D003704:Dementia / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011699:Putamen / Q000033:anatomy & histology; D012720:Severity of Illness Index; D025801:Ubiquitin / Q000378:metabolism*; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D025801:Ubiquitin; D016875:tau Proteins