title: Age-related bone mineral density, bone loss rate, prevalence of osteoporosis, and reference database of women at multiple centers in China.
abstract: Our study surveyed age-related bone mineral density (BMD), bone loss rate, and prevalence of osteoporosis in women at multiple research centers in China. Survey results were used to establish a BMD reference database for the diagnosis of osteoporosis in Chinese women nationwide. We used dual-energy X-ray absorptiometry bone densitometers to measure BMD at posteroanterior (PA) lumbar spine (L1-L4; n=8142) and proximal femur (n=7290) in female subjects of age 20-89 yr from Beijing, Shanghai, Guangzhou, Chengdu, Nanjing, and Jiaxing. A cubic regression-fitting model was used to describe the change of BMD with age at various skeletal sites. Peak BMD occurred between 30 and 34 yr of age for femur neck and total femur, and between 40 and 44 yr for spine and trochanter measurement sites. Young adult (YA) BMD values (mean and standard deviation [SD], calculated as the average BMD in the age range of 20-39, were 1.116+/-0.12, 0.927+/-0.12, 0.756+/-0.11, and 0.963+/-0.13 g/cm2 at PA spine, femoral neck, trochanter, and total femur, respectively. The BMD of 85-yr-old women reflected a loss of 32% at the spine and 30-35% at femur measurement sites. The prevalence of osteoporosis, defined as a BMD of <or=-2.5 SDs from YA values established in this study, in female subjects of age 50 yr or older, was 28% for the spine, 15% for any femur site, and 31% for any spine or femur site. This study provides important information for formulating osteoporosis prevention and treatment strategies in Chinese women, and it establishes a reliable BMD reference database for the diagnosis of osteoporosis of Chinese women nationwide.
authors.affiliation: Ji Shui Tan Hospital, Beijing, China.
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Cheng
authors.forename: Ding-Zhuo
authors.initials: DZ
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
authors.forename: Tie-Jun
authors.initials: TJ
authors.lastname: Zhuo
authors.forename: Hua-Chou
authors.initials: HC
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Xiang
authors.forename: Hong-Fu
authors.initials: HF
authors.lastname: Wang
authors.forename: Ping-Zhong
authors.initials: PZ
authors.lastname: Ou
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Gong-Yi
authors.initials: GY
authors.lastname: Huang
authors.forename: Qi-Ren
authors.initials: QR
authors.lastname: Huang
authors.forename: Howard S
authors.initials: HS
authors.lastname: Barden
authors.forename: Linda S
authors.initials: LS
authors.lastname: Weynand
authors.forename: Ken G
authors.initials: KG
authors.lastname: Faulkner
authors.forename: Xun-Wu
authors.initials: XW
authors.lastname: Meng
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D002681:China / Q000453:epidemiology; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007867:Leg Bones; D008159:Lumbar Vertebrae; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology*; D012016:Reference Values; D015203:Reproducibility of Results