title: [Endometrial hyperplasias immunohistochemical aspects].
abstract: Endometrial hyperplasias are now diagnosed according to the histopathological examination. By using immunohistochemistry, the authors search for supplementary elements for the diagnosis and evaluation of the prognosis of this nosologic framework.
  
  
  METHODS
  We investigated a number of 138 cases of endometrial hyperplasia, using immunohistochemical research. The avidine-biotin-peroxidase method revealed estrogenic and progesterone receptors, together with EGF, proliferative Ki67 and cyclin D1.
  
  
  RESULTS
  The reaction was positive in variable percents for estrogenic receptors, especially for complex atypical hyperplasias. A positive immunoreactivity was also found for progesterone receptors and for Ki67 (in atypical hyperplasias); cyclin D1 revealed only a moderate reaction.
  
  
  CONCLUSIONS
  Immunohistochemistry can be useful for the prognosis of the lesion, but it is not indispensable for diagnosis, while the histopathologic examination is absolutely necessary for a complete endometrial hyperplasia diagnosis.
authors.affiliation: Disciplina de Histologie, Facultatea de Medicină, Universitatea de Medicină si Farmacie "Gr. T. Popa", Iaşi.
authors.forename: S
authors.initials: S
authors.lastname: Abushab
authors.forename: Raluca
authors.initials: R
authors.lastname: Balan
authors.forename: C
authors.initials: C
authors.lastname: Cotuţiu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D019938:Cyclin D1 / Q000378:metabolism; D004714:Endometrial Hyperplasia / Q000175:diagnosis* / Q000378:metabolism; D004815:Epidermal Growth Factor; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D019394:Ki-67 Antigen / Q000378:metabolism; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D019938:Cyclin D1; D004815:Epidermal Growth Factor