Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population.
We have examined the association of phosphodiesterase 4D (PDE4D) single nucleotide polymorphism (SNP45) and microsatellite marker AC008818-1 with ischaemic stroke, in an independent cohort of Greek patients and control individuals with no clinical manifestations of vascular disease. Significantly different distributions were observed with respect to the AC008818-1 alleles, with allele 148 associating with an increased risk of stroke incidence, and allele 144 with a protective effect. In addition, the haplotype defined by allele 148 and G allele of SNP45 was found to be significantly increased in patients even though no statistically significant differences emerged with respect to SNP45 alone. The previously established association of a PDE4D gene haplotype with ischaemic stroke in a population from Iceland was independently confirmed in our Greek population, suggesting that PDE4D may be involved in the aetiology and pathogenesis of stroke.
Fidani
L
L
Department of General Biology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece. lfidani@med.auth.gr
Clarimon
J
J
Goulas
A
A
Hatzitolios
A I
AI
Evans
W
W
Tsirogianni
E
E
Hardy
J
J
Kotsis
A
A
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000235:genetics* / Q000502:physiology; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics*; D015331:Cohort Studies; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006115:Greece / Q000453:epidemiology; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D008297:Male; D020641:Polymorphism, Single Nucleotide
D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C517376:PDE4D protein, human