Nuclear mechanics and methods.
The role of the nucleus in protecting and sequestering the genome is intrinsically mechanical, and disease-causing structural mutants in lamins and other components underscore this function. Various methods to measure nuclear mechanics, isolated or in situ, are outlined here in some detail.
Lammerding
Jan
J
Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital,/Harvard Medical School, Boston, Massachusetts 02115, USA.
Dahl
Kris Noel
KN
Discher
Dennis E
DE
Kamm
Roger D
RD
D001696:Biomechanical Phenomena / Q000379:methods*; D002467:Cell Nucleus / Q000737:chemistry* / Q000648:ultrastructure; D003599:Cytoskeleton / Q000737:chemistry; D012212:Rheology / Q000379:methods