FOXP1: a potential therapeutic target in cancer.
Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors which have a broad range of functions. Foxp1 is widely expressed and has been shown to have a role in cardiac, lung and lymphocyte development. FOXP1 is targeted by recurrent chromosome translocations and its overexpression confers a poor prognosis in a number of types of lymphomas, suggesting it may function as an oncogene. In contrast, FOXP1 localises to a tumour suppressor locus at 3p14.1 and loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting FOXP1 may function as a tumour suppressor in other tissue types. These data suggest that FOXP1 may not only be useful in prognosis but also may be used to develop FOXP1-directed therapeutic strategies.
Koon
Henry B
HB
Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA, USA.
Ippolito
Gregory C
GC
Banham
Alison H
AH
Tucker
Philip W
PW
D000818:Animals; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D009857:Oncogenes / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*
C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins