Prenylated xanthones from the root bark of Cudrania tricuspidata.
Four new prenylated xanthones, cudratricusxanthones J-M (1-4), were isolated from the CH2Cl2-soluble extract of the root bark of Cudrania tricuspidata, along with four known prenylated xanthones, isocudraxanthone K (5), cudraxanthone C (6), cudratricusxanthone A (7), and cudraxanthone L (8), and three known prenylated flavonoids, cudraflavone A (9), cudraflavanone A (10), and cudraflavone B (11). The structures of compounds 1-4 were elucidated using spectroscopic methods. Cudratricusxanthone A (7), cudraflavanone A (10), and cudraflavone B (11) showed moderate inhibitory effects on mouse brain monoamine oxidase (MAO) with IC50 values of 88.3, 89.7, and 80.0 microM, respectively.
Hwang
Ji Hye
JH
College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, Korea.
Hong
Seong Su
SS
Han
Xiang Hua
XH
Hwang
Ji Sang
JS
Lee
Dongho
D
Lee
Heesoon
H
Yun
Yeo Pyo
YP
Kim
Youngsoo
Y
Ro
Jai Seup
JS
Hwang
Bang Yeon
BY
D000818:Animals; D001921:Brain / Q000201:enzymology; D051379:Mice; D015394:Molecular Structure; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029586:Moraceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors; D044004:Xanthones