title: Phenylimidazole derivatives as new inhibitors of bacterial enoyl-ACP reductase FabK.
abstract: Novel FabK inhibitors with antibacterial activity against Streptococcus pneumoniae were synthesized and evaluated. Through SAR studies of our initial hit compound 2-(1H-benz[d]imidazol-2-ylthio)-N-(6-methoxycarbonylbenzo[d]thiazol-2-yl)acetamide, a series of novel phenylimidazole derivatives were discovered as potent FabK inhibitors.
authors.affiliation: Medicinal Chemistry Research Laboratories, Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, Yokohama, Japan. hideo_kitagawa@meiji.co.jp
authors.forename: Hideo
authors.initials: H
authors.lastname: Kitagawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ozawa
authors.forename: Sho
authors.initials: S
authors.lastname: Takahata
authors.forename: Maiko
authors.initials: M
authors.lastname: Iida
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D013296:Streptococcus pneumoniae / Q000201:enzymology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D007093:Imidazoles; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)