title: Stereoselective formal total synthesis of (+)-methynolide.
abstract: A highly stereoselective and convergent formal total synthesis of (+)-methynolide is described. The salient features of this synthesis have been the construction of the C1-C7 and C8-C11fragments via a desymmetrization approach, Sharpless asymmetric epoxidation of an allyl alcohol, respectively, and linkage of both the fragments by Nozaki-Hiyama-Kishi reaction.
authors.affiliation: Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. yadavpub@iict.res.in
authors.forename: J S
authors.initials: JS
authors.lastname: Yadav
authors.forename: T V
authors.initials: TV
authors.lastname: Pratap
authors.forename: V
authors.initials: V
authors.lastname: Rajender
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D018942:Macrolides / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C522940:methynolide