title: Pathologically different features and fibrosis scores in chronic hepatitis C genotypes 3 and 1.
abstract: BACKGROUND
  Chronic hepatitis C genotypes 3 and 1 are the two most common genotypes in Thailand.
  
  
  OBJECTIVE
  Identify the pathologically different features between genotypes 3 and land to compare the fibrosis score of Knodell HAI and Ishak modified HAI.
  
  
  METHODS
  The pathological features of 114 liver biopsies were evaluated.
  
  
  RESULTS
  Steatosis was more commonly found in genotype 3 than in genotype 1 (97.1% vs. 77.8%, p = 0.001). Portal lymphoid follicles were commonly found, but bile duct damage was uncommon. The majority of portal tracts showed partial involvement. The majority of patients had Knodell fibrosis 1 and Ishak fibrosis 3.
  
  
  CONCLUSIONS
  Steatosis is significantly more common in genotype 3, while other features do not show any differences. The portal tracts show partial involvement because inflammatory cells tend to aggregate and form lymphoid follicles. The most comparable fibrosis scores are Knodell fibrosis 1 and Ishak fibrosis 3.
authors.affiliation: Department of Pathology, Faculty of Medicine Siriraj Hospital, 2 Pran-nok Rd, Bangkok-noi, Bangkok 10700, Thailand. siama@mahidol.ac.th
authors.forename: Ananya
authors.initials: A
authors.lastname: Manuyakorn
authors.forename: Tawesak
authors.initials: T
authors.lastname: Tanwandee
authors.forename: Kanit
authors.initials: K
authors.lastname: Atisook
mesh_terms: D000328:Adult; D001706:Biopsy; D005234:Fatty Liver / Q000235:genetics / Q000473:pathology; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013785:Thailand