No association between TGFBR1*6A and lung cancer.
BACKGROUND
TGFBR1*6A, a functionally polymorphic allele in the transforming growth factor [beta] receptor 1 gene (TGFBR1), has been hypothesized to increase risk of various cancers. However, little has been documented about connection of this variant with lung cancer.


METHODS
In an attempt to explore whether the TGFBR1*6A is associated with lung cancer, we performed genotyping followed by sequencing in 252 patients with lung cancer and 250 healthy controls.


RESULTS
The frequency for the heterozygote 9A/6A is 13.9% in cases compared with 12.4% in controls, and the odds ratio is 1.14 (95% confidence interval: 0.68-1.91), which is not statistically significant (p = 0.62), suggesting that TGFBR1*6A could not be a cancer susceptibility factor for Chinese patients with lung cancer.


CONCLUSIONS
We have no evidence to support the hypothesis that TGFBR1*6A is associated with lung cancer.
You
Weiming
W
Laboratory of Medical Genetics, School of Life Sciences, Suzhou University, Suzhou PR China.
Liu
Zeyi
Z
Zhao
Jun
J
Zheng
Mingfeng
M
Zheng
Shi-Ying
SY
Liu
Xia
X
Zhang
Hong-Tao
HT
D017677:Age Distribution; D000483:Alleles; D002681:China / Q000453:epidemiology; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017346:Protein Serine-Threonine Kinases / Q000097:blood / Q000235:genetics*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000097:blood / Q000235:genetics*; D017678:Sex Distribution
D004273:DNA, Neoplasm; D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; C000625841:TGFBR1 protein, human