Stereochemistry of pladienolide B.
Pladienolide B is a 12-membered macrolide isolated from Streptomyces platensis Mer-11107. It showed potent in vitro and in vivo antitumor activities and is a potential lead for novel antitumor agents. The absolute configurations at ten chiral centers were determined on the basis of spectral data of pladienolide B and its chemical transformation products.
Asai
Naoki
N
Tsukuba Research Laboratories, Eisai Co., Ltd, Tokodai, Tsukuba, Ibaraki, Japan. n2-asai@hhc.eisai.co.jp
Kotake
Yoshihiko
Y
Niijima
Jun
J
Fukuda
Yoshio
Y
Uehara
Taisuke
T
Sakai
Takashi
T
D000970:Antineoplastic Agents / Q000737:chemistry; D004852:Epoxy Compounds / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry
D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D018942:Macrolides; C522342:pladienolide B