Overcoming the demons of protecting groups with amphoteric molecules.
Synthetic organic chemists have long depended on protecting group manipulations when faced with the challenges of chemoselectivity and functional group incompatibility. Overcoming this dependence will improve the overall efficiency of chemical synthesis. By taking advantage of orthogonally reactive functional groups, amphoteric molecules can afford access not only to more efficient and strategic syntheses but also to the development of novel chemical transformations.
Yudin
Andrei K
AK
Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto ON, M5S3H6, Canada. ayudin@chem.utoronto.ca
Hili
Ryan
R