Trichophytic Majocchi granuloma mimicking Kaposi sarcoma.
A 68-year-old man presented with a one month history of painful blue-red papules and nodules on an erythematous base on the top of his feet, as well as dystrophic toenails. He had undergone renal transplantation six months previously for membranous glomerulonephritis, and was immunosuppressed with tacrolimus 3 g, mycophenolate mofetil 1500 mg and prednisolone 5 mg daily. His tacrolimus level was 29.8 ng/ml (expected level 6-8 ng/ml). Even though the cutaneous lesions strongly suggested Kaposi sarcoma, the histological examination revealed a dermal abscess in which hyphae and spores were seen with PAS staining. ELISA-PCR of the biopsy identified Trichophyton rubrum, which was also grown on culture of the biopsy tissue. The diagnosis of Majocchi granuloma secondary to excessive immunosuppression was made. Systemic treatment with terbinafine 250 mg per day and topical ciclopirox olamine completely cured the granulomatous skin lesions, and later the nails.
Brod
Corinna
C
Universitäts-Hautklinik, Eberhard-Karls-Unievrsität Tübingen, Tübingen, Germany.
Benedix
Frauke
F
Röcken
Martin
M
Schaller
Martin
M
D000287:Administration, Topical; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage; D000077768:Ciclopirox; D003937:Diagnosis, Differential; D006099:Granuloma / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D011728:Pyridones / Q000008:administration & dosage; D012514:Sarcoma, Kaposi / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology; D014005:Tinea / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D011728:Pyridones; D000077768:Ciclopirox