title: Circadian rhythm of apoprotein H (beta2-glycoprotein-1) in human plasma.
abstract: Many physiological, biochemical, and behavioral processes are under circadian regulation, which is generated by an internal time-keeping mechanism referred to as biological clock. The regulators of circadian rhythm in human plasma have not been completely elucidated. Here we demonstrated that the isolated protein from human plasma, which down-regulated expression level of cry1 in Jurkat cells, was apoprotein H (ApoH). Further, mRNA expression level of ApoH indicated circadian rhythm in Jurkat cells. The concentration of ApoH was subject to circadian rhythm in human plasma. These experimental results suggested that ApoH may be one of the members of the regulator of circadian rhythm and that ApoH expression level was also dependent on circadian rhythm in Jurkat cells and in human plasma.
authors.affiliation: Department of Surgery II, Fukushima Medical University School of Medicine, Hikarigaoka-1, Fukushima, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Higashimoto
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Homma
authors.forename: Miyuki
authors.initials: M
authors.lastname: Umetsu
authors.forename: Yuri
authors.initials: Y
authors.lastname: Konno
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ono
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yoshimoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Momma
authors.forename: Masaru
authors.initials: M
authors.lastname: Saito
authors.forename: Seiichi
authors.initials: S
authors.lastname: Takenoshita
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takebayashi
mesh_terms: D001683:Biological Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D019169:Jurkat Cells; D009991:Oscillometry / Q000379:methods; D053482:beta 2-Glycoprotein I / Q000097:blood*
chemical_list: D053482:beta 2-Glycoprotein I