title: Influence of a lipophilic drug on the stability of emulsions: an important approach on the development of lipidic carriers.
abstract: The aim of this work was to investigate the influence of a lipophilic drug, Ibuprofen, on the stability of o/w emulsions. Five formulations were prepared by the phase inversion temperature (PIT) method, and Ibuprofen was incorporated into their oil phase. Emulsion stability was evaluated by short- and long-term studies. Concerning the former, stability under centrifugation showed an improved profile for Ibuprofen-loaded emulsions. The latter confirmed such findings. In conclusion, a rather resistant interfacial film may take place when Ibuprofen was incorporated into the emulsions. Therefore, the critical hydrophilic-lipophilic-balance (HLB) of o/w emulsions can be affected by a lipophilic drug into their oil phase. Such approach is of great importance on the development of lipid carriers for therapeutic drug targeting.
authors.affiliation: Universidade Federal do Rio Grande do Norte, Programa de Pós Graduação em Ciências da Saúde, Laboratório de Sistemas Dispersos, Natal/RN, Brazil.
authors.forename: F R
authors.initials: FR
authors.lastname: Formiga
authors.forename: I A A
authors.initials: IA
authors.lastname: Fonseca
authors.forename: K B
authors.initials: KB
authors.lastname: Souza
authors.forename: A K A
authors.initials: AK
authors.lastname: Silva
authors.forename: J P F
authors.initials: JP
authors.lastname: Macedo
authors.forename: I B
authors.initials: IB
authors.lastname: Araújo
authors.forename: L A L
authors.initials: LA
authors.lastname: Soares
authors.forename: E Socrates T
authors.initials: ES
authors.lastname: Egito
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D045703:Emulsifying Agents / Q000737:chemistry; D004655:Emulsions / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry*; D008899:Mineral Oil / Q000737:chemistry; D012212:Rheology; D014867:Water / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D045703:Emulsifying Agents; D004655:Emulsions; D014867:Water; D008899:Mineral Oil; D007052:Ibuprofen