title: Time course of cerebral hemodynamics in cryptococcal meningitis in HIV-negative adults.
abstract: To evaluate the cerebral hemodynamics in cryptococcal meningitis (CM) patients using non-invasive studies. Serial trans-cranial color-coded sonography (TCCS) and magnetic resonance angiography (MRA) studies were performed to measure the cerebral vasculopathy of 12 HIV-negative CM patients. With TCCS, 8 of the 22 middle cerebral arteries (MCAs) showed stenotic velocities, whereas the time-mean velocity (V(mean)) of the 20 anterior cerebral arteries (ACAs), 22 posterior cerebral arteries (PCAs), and 12 basilar arteries (BAs) did not. In total, five patients had stenotic velocities, three of whom had bilateral M1 stenosis (<50%), whilst two had unilateral M1 stenosis (<50%). The V(mean) of MCA increased from day 1 to day 35 and substantially decreased thereafter. The mean Pulsatility Index (PI) in the studied vessels was higher during the study period. A mismatch of the findings between TCCS and MRA studies were also demonstrated. There was a high incidence and a longer time-period of disturbed cerebral hemodynamics during the clinical course of CM. However, because of the limited case numbers for this study, further large-scale studies are needed to delineate the clinical characteristics and therapeutic influence of cerebrovascular insults in HIV-negative CM patients.
authors.affiliation: Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center and Chang Gung University College of Medicine, Kaohsiung, Taiwan. cwenneng@ms19.hinet.net
authors.forename: W-N
authors.initials: WN
authors.lastname: Chang
authors.forename: C-H
authors.initials: CH
authors.lastname: Lu
authors.forename: H-W
authors.initials: HW
authors.lastname: Chang
authors.forename: C-C
authors.initials: CC
authors.lastname: Lui
authors.forename: N-W
authors.initials: NW
authors.lastname: Tsai
authors.forename: C-R
authors.initials: CR
authors.lastname: Huang
authors.forename: H-C
authors.initials: HC
authors.lastname: Wang
authors.forename: Y-C
authors.initials: YC
authors.lastname: Chuang
authors.forename: S-F
authors.initials: SF
authors.lastname: Chen
authors.forename: C-C
authors.initials: CC
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D003251:Constriction, Pathologic; D005260:Female; D006801:Humans; D015994:Incidence; D020244:Infarction, Middle Cerebral Artery / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D020762:Infarction, Posterior Cerebral Artery / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D018810:Magnetic Resonance Angiography; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications / Q000401:mortality / Q000503:physiopathology*; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000503:physiopathology; D020769:Posterior Cerebral Artery / Q000503:physiopathology; D011446:Prospective Studies; D013624:Taiwan / Q000453:epidemiology; D016896:Treatment Outcome; D017585:Ultrasonography, Doppler, Transcranial