The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS).
New findings lead to a revised understanding of the substrates' binding order, the role of the substrate as an activator, and the observed lag phase in the FDTS catalyzed reaction.
Chernyshev
Anatoly
A
Department of Chemistry, The University of Iowa, Iowa City, IA, USA.
Fleischmann
Todd
T
Koehn
Eric M
EM
Lesley
Scott A
SA
Kohen
Amnon
A
D005415:Flavins / Q000378:metabolism*; D009705:Nucleosides / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D013940:Thymidylate Synthase / Q000378:metabolism*
D005415:Flavins; D009705:Nucleosides; D010088:Oxidoreductases; D013940:Thymidylate Synthase