title: Predicting the drug concentration in starch acetate matrix tablets from ATR-FTIR spectra using multi-way methods.
abstract: The amounts of drug and excipient were predicted from ATR-FTIR spectra using two multi-way modelling techniques, parallel factor analysis (PARAFAC) and multi-linear partial least squares (N-PLS). Data matrices consisted of dissolved and undissolved parallel samples having different drug content and spectra, which were collected at axially cut surface of the flat-faced matrix tablets. Spectra were recorded comprehensively at different points on the axially cut surface of the tablet. The sample drug concentrations varied between 2 and 16% v/v. The multi-way methods together with ATR-FTIR spectra seemed to represent an applicable method for the determination of drug and excipient distribution in a tablet during the release process. The N-PLS calibration method was more robust for accurate quantification of the amount of components in the sample whereas the PARAFAC model provided approximate relative amounts of components.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland. sanni.matero@uku.fi
authors.forename: Sanni
authors.initials: S
authors.lastname: Matero
authors.forename: Jari
authors.initials: J
authors.lastname: Pajander
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Soikkeli
authors.forename: Satu-Pia
authors.initials: SP
authors.lastname: Reinikainen
authors.forename: Maija
authors.initials: M
authors.lastname: Lahtela-Kakkonen
authors.forename: Ossi
authors.initials: O
authors.lastname: Korhonen
authors.forename: Jarkko
authors.initials: J
authors.lastname: Ketolainen
authors.forename: Antti
authors.initials: A
authors.lastname: Poso
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry; D011237:Predictive Value of Tests; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013213:Starch / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D013607:Tablets
chemical_list: D004364:Pharmaceutical Preparations; D013607:Tablets; D013213:Starch; C050766:starch acetate