title: Analytical solutions for nonlinear cable equations with calcium dynamics. II. Saltatory transmission in a sparsely excitable cable model.
abstract: In order to gain a better theoretical understanding of the interaction between voltage and calcium influx, we present the simulation results for saltatory transmission in a sparsely excitable model of a continuous cylindrical segment of nerve fiber, where calcium diffuses internally and various ion channels are distributed as hotspots along the cable. A standard set of ion channel descriptions is used to illustrate how different numbers and distributions of ion channel hotspots affect the propagation and transmission of a single action potential and/or a spike train and how such hotspots affect calcium influx and diffusion within continuous cylindrical segment of nerve fiber.
authors.affiliation: Laboratory for Visual Neurocomputing, Brain Science Institute, RIKEN, 2-1 Hirosawa Wako-shi, Saitama 351-0198, Japan. nicolang@brain.riken.jp
authors.forename: Nicolangelo
authors.initials: N
authors.lastname: Iannella
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003198:Computer Simulation; D004058:Diffusion; D004594:Electrophysiology; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008959:Models, Neurological; D009412:Nerve Fibers / Q000378:metabolism / Q000502:physiology*; D017711:Nonlinear Dynamics; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D007473:Ion Channels; D002118:Calcium