HLA-B51 gene and its expression in association with Behçet's Disease in Denizli Province of Turkey.
Behçet's Disease (BD) is a multisystemic inflammatory disorder as a triad of symptoms including recurrent oral and genital aphthous ulceration, and uveitis with unknown pathogenesis. Many researchers have tried to investigate the association of HLA-B51 gene with the BD. We aimed to investigate the association of the HLA-B51 gene and its expression, also polymorphic structure by PCR, RT-PCR and sequence specific oligonucleotide primers and probes in BD patients (n: 35) and control group (n: 50). According to our results, we did not observe any association in between HLA-B51 gene, its polymorphism, expression and BD patients.
Atalay
Ayfer
A
Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey. aatalay@pau.edu.tr
Yildiz-Demirtepe
Sanem
S
Tatlipinar
Sinan
S
Sanli-Erdoğan
Berna
B
Cobankara
Veli
V
Yildirim
Cem
C
Bağci
Hüseyin
H
Atalay
Erol Omer
EO
D001528:Behcet Syndrome / Q000235:genetics* / Q000276:immunology*; D001665:Binding Sites; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology*; D059949:HLA-B51 Antigen; D006262:Health; D006801:Humans; D008297:Male; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D014421:Turkey; D001613:beta 2-Microglobulin / Q000235:genetics / Q000378:metabolism
D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D012333:RNA, Messenger; D011948:Receptors, Antigen, T-Cell; D001613:beta 2-Microglobulin; C490245:GEM protein, human; D020559:Monomeric GTP-Binding Proteins