Biomarkers of oxidative stress and antioxidant status in children born small for gestational age: evidence of lipid peroxidation.
Children born small for gestational age are known to be at increased risk for adult diseases such as hypertension, diabetes, and coronary heart disease. Oxidative stress is a common feature of these pathogenic conditions and can be the key link between size at birth and increased morbidity later in life. The purpose of this study was to analyze the parameters of lipoperoxidation and changes in antioxidant defense system as well as assess their relationship to birth weight. Concentrations of thiobarbituric-acid-reactive-substances and F2-isoprostanes, total antioxidant status, and the activity of both superoxide dismutase and glutathione peroxidase were measured in 65 children (33 boys, 32 girls; ages 8-13 y). Thiobarbituric-acid-reactive-substances and F2-isoprostane levels were significantly elevated in children born small for gestational age. Nevertheless, superoxide dismutase activity was significantly elevated in these children and the levels of both glutathione peroxidase activity and total antioxidant status were unchanged. Moreover, we found that systolic blood pressure was positively associated with thiobarbituric-acid-reactive-substances levels in race- and gender-adjusted models but not in a multivariable regression model. In conclusion, the current study revealed that there is evidence of oxidative stress in children born small for gestational age as supported by increased lipid peroxidation.
Franco
Maria C P
MC
Division of Nephrology, School of Medicine, Federal University of São Paulo, 04023-900 São Paulo, Brazil. mdcfranco@nefro.epm.br
Kawamoto
Elisa M
EM
Gorjão
Renata
R
Rastelli
Viviani M F
VM
Curi
Rui
R
Scavone
Cristoforo
C
Sawaya
Ana Lydia
AL
Fortes
Zuleica Bruno
ZB
Sesso
Ricardo
R
D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001724:Birth Weight; D001794:Blood Pressure; D001938:Brazil; D019352:Censuses; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology; D028441:F2-Isoprostanes / Q000652:urine; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood / Q000378:metabolism* / Q000652:urine; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D018384:Oxidative Stress; D011204:Poverty Areas; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014527:Uric Acid / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D028441:F2-Isoprostanes; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D014527:Uric Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase