Cell cycle: on-time delivery of Plk1 during cytokinesis.
At anaphase, the kinase Plk1 localizes to the spindle midzone, where it orchestrates cytokinesis. New work has now identified PRC1 as a Plk1-delivery factor that is tightly controlled by opposing cyclin B-Cdk1- and Plk1-dependent phosphorylations.
Rape
Michael
M
Department of Molecular and Cell Biology, Division of Cell and Developmental Biology, University of California at Berkeley, Berkeley, CA 94720-3202, USA. mrape@calmail.berkeley.edu
D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D048749:Cytokinesis / Q000502:physiology*; D006801:Humans; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D000097869:Polo-Like Kinase 1
D018797:Cell Cycle Proteins; D018844:Cyclin-Dependent Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1; C116662:PRC1 protein, human