Uncomplicated outcome after an accidental overdose of nevirapine in a newborn.
We report the first case of a massive accidental overdose of nevirapine in a 1-week newborn, due to confusion between nevirapine (Viramune) and nelfinavir (Viracept). The drug was eliminated spontaneously and quickly. We only observed mild neutropenia and hyperlactatemia, which regressed on its own without any clinical complication. Despite the good evolution of this massive overdose, physicians should be aware of confusion risks between some antiretroviral drugs.
Brasme
Jean-François
JF
Assistance Publique-Hôpitaux de Paris, Hôpital Robert-Debré, Pediatric Intensive Care Unit, 48, boulevard Sérurier, 75019 Paris, France.
Mille
Frédéric
F
Benhayoun
Mounir
M
Bavoux
Françoise
F
Faye
Albert
A
Teissier
Natacha
N
Lachassinne
Eric
E
Dauger
Stéphane
S
D019380:Anti-HIV Agents / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008508:Medication Errors; D019888:Nelfinavir / Q000627:therapeutic use; D019829:Nevirapine / Q000506:poisoning*
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D019829:Nevirapine; D019888:Nelfinavir