title: Formal total syntheses of aspidosperma alkaloids via a novel and general synthetic pathway based on an intramolecular Heck cyclization.
abstract: Cyclizations of bicyclic amides via an intramolecular Heck reaction followed by an oxidation reaction generate tricyclic spirocyclohexadienones. From these compounds, tetracyclic ketones can be synthesized to provide useful intermediates for the synthesis of indole alkaloids.
authors.affiliation: Institut de Chimie des Substances Naturelles, Bt 27, CNRS Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Pereira
authors.forename: Mireille
authors.initials: M
authors.lastname: Barlier
authors.forename: Catherine
authors.initials: C
authors.lastname: Guillou
mesh_terms: D030009:Aspidosperma / Q000737:chemistry; D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D031451:Strychnos / Q000737:chemistry
chemical_list: D026121:Indole Alkaloids