[Effect of Xianlong granules on immunological function in rats of adjuvant arthritis].
OBJECTIVE
To study the effect of Xianlong granules (XLG) on immunological function in the rat of adjuvant arthritis (AA).


METHODS
Rats were randomly divided into normal group, AA model group, prednisone group and low, middle and high dose XLG groups, 10 rats in each group. All rats were treated by intragastric administration from the 18 days after arthritis was induced by the complete Freud's adjuvant and the effect of XLG on toes swelling was observed. On the 30th days after modeling, proliferation of the splenic and thymic lymphocytes, and IgG secreted by splenocytes were detected respectively by MTT assay and ELISA.


RESULTS
Compared with the model group, both the high and middle dose XLG groups had significant therapeutic effects on toes dwelling in the rat of AA (P < 0.05 or P < 0.01); The low, middle and high dose XLG groups strengthened the PHAM-inhibited proliferation of splenic lymphocytes (P < 0.05), and inhibited the PHAM-augmented proliferation of thymic lymphocytes (P < 0.05); XLG did not significantly effect on IgG level secreted by splenocytes in rats of AA.


CONCLUSIONS
XLG can cure toes swelling in rats of AA, which is related with regulation of the abnormal immunlological function.
Wang
Wei-Zhuo
WZ
Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
Guo
Xiong
X
Chen
Jun-Chang
JC
Yuan
Pu-Wei
PW
Liu
Yi-Heng
YH
Li
Yan-Min
YM
D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D049109:Cell Proliferation / Q000187:drug effects; D017812:Colubridae; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004487:Edema / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D005260:Female; D007074:Immunoglobulin G / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D008516:Medicine, Chinese Traditional; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D014034:Toes / Q000473:pathology
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007074:Immunoglobulin G; D008419:Materia Medica