title: [Status of vaccination against hepatitis B among postgraduate students in medical higher education institutions in Guangzhou].
abstract: OBJECTIVE
  To investigate the status of vaccination against hepatitis B among postgraduate students of medical institutions of higher education in Guangzhou.
  
  
  METHODS
  HBsAg and anti-HBs in the serum samples from 1139 postgraduate students were detected by ELISA. Data on hepatitis B vaccine inoculation were investigated by using a questionnaire. Statistical analyses were performed by using SAS software.
  
  
  RESULTS
  The HBsAg positive rate among the 1139 postgraduate students was 2.90 percent. The HBsAg positive rates in hepatitis B vaccine inoculated (1.15 percent) and non- inoculated (21.69 percent) postgraduate students were significantly different (x2=119.11, P<0.0001). The positive rates of HBsAb between the two groups were also significantly different (x2=62.05, P<0.0001). Among the hepatitis B vaccine inoculated students, 17.31 percent were negative for HBsAb. The positive rate of HBsAb among those inoculated the vaccine within the past 3 years was higher than that among those inoculated the vaccine earlier (0-3 years vs. 4-6 year, P=0.0089) (0-3 years vs. 7-9 years, P=0.0172) (0-3 years vs. >9 years, P=0.0474). The positive rate of HBsAb among the students who received hepatitis B vaccine booster dose was higher than that of the students who did not receive any booster dose (P=0.0093).
  
  
  CONCLUSIONS
  With the increase of ages, the effect of vaccination for hepatitis B decreased. Male populations may be more susceptible to hepatitis B virus than female. It is necessary to monitor HBsAb levels for those who were inoculated with HBV vaccine more than 3 years ago to give booster dose in time to prevent HBV infection.
authors.affiliation: The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Chao-shuang
authors.initials: CS
authors.lastname: Lin
authors.forename: Jian-yun
authors.initials: JY
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Mai
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Lee
authors.forename: Zhi-liang
authors.initials: ZL
authors.lastname: Gao
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013337:Students, Medical; D011795:Surveys and Questionnaires; D014611:Vaccination; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines