title: Preliminary antinociceptive, antioxidant and cytotoxic activities of Leucas aspera root.
abstract: The ethanolic extract of Leucas aspera root was subjected to acetic acid induced writhing inhibition, 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging assay and brine shrimp lethality bioassay for screening of antinociceptive, antioxidant and cytotoxic activity, respectively. The extract produced significant writhing inhibition in acetic acid induced writhing in mice at the doses of 250 and 500 mg/kg. The extract showed a significant free radical scavenging activity with an IC(50) of 8 microg/ml. The extract showed significant lethality to brine shrimp with an LC(50) value.
authors.affiliation: Phytochemistry and Pharmacology Research Laboratory, Pharmacy discipline, Khulna University, Khulna-9208, Bangladesh. shafiur27@yahoo.com
authors.forename: M S
authors.initials: MS
authors.lastname: Rahman
authors.forename: S K
authors.initials: SK
authors.lastname: Sadhu
authors.forename: C M
authors.initials: CM
authors.lastname: Hasan
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001156:Artemia / Q000187:drug effects; D001713:Biphenyl Compounds; D004305:Dose-Response Relationship, Drug; D005260:Female; D020128:Inhibitory Concentration 50; D019686:Lamiaceae; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots
chemical_list: D000700:Analgesics; D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl