Carvedilol increases copper-zinc superoxide dismutase activity in patients with acute myocardial infarction.
Balanced and coordinated antioxidant defence enzyme activities are of utmost importance for correct physiological function and for shielding against unwelcome pathological conditions. We determined the activities of copper-zinc superoxide dismutase (CuZnSOD), catalase, glutathione peroxidase and glutathione reductase in erythrocytes isolated from patients receiving different therapy (streptokinase alone or in combination with metoprolol or with carvedilol) for up to 168 hr after starting treatment for acute myocardial infarction. We observed increased CuZnSOD activity in erythrocytes isolated from patients treated with streptokinase-carvedilol (after 6, 24 and 168 hr) and in erythrocytes isolated from patients treated with streptokinase-metoprolol (after 24 hr). In addition, positive correlation between CuZnSOD and catalase activities was found in erythrocytes isolated from patients that received streptokinase-carvedilol after 168 hr. As metoprolol does not react directly with hydrogen peroxide, it would appear that combined streptokinase-metoprolol therapy exerted its effects primarily via by beta-blockade whereas combined streptokinase-carvedilol therapy appeared to function via both beta-blockade and direct antioxidant mechanisms.
Kastratović
Dragana A
DA
Centre for Clinical Pharmacology, Clinical Centre of Serbia, Belgrade, Serbia. maca.kastratovic@kcs.ac.yu
Vasiljević
Zorana M
ZM
Spasić
Mihajlo B
MB
Perunicić
Jovan P
JP
Matić
Mihajlo
M
Blagojević
Dusko P
DP
Mijalković
Dejan N
DN
Antonijević
Nebojsa M
NM
Marković
Srdjan Z
SZ
Gojković-Bukarica
Ljiljana
L
Stojiljkovic
Milos P
MP
Lasica
Ratko M
RM
Jones
David R
DR
Nikolić-Kokić
Aleksandra L
AL
D018674:Adrenergic Antagonists / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism*; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology*; D011412:Propanolamines / Q000627:therapeutic use*; D013300:Streptokinase / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism*
D018674:Adrenergic Antagonists; D002227:Carbazoles; D016166:Free Radical Scavengers; D011412:Propanolamines; D000077261:Carvedilol; D013482:Superoxide Dismutase; D013300:Streptokinase; D008790:Metoprolol