Prognosis of primary mucosal penile melanoma: a series of 19 Dutch patients and 47 patients from the literature.
OBJECTIVE
To analyze the clinical features, prognostic factors, and survival of male patients with primary mucosal melanoma on the glans penis, meatus, fossa navicularis, and distal urethra.


METHODS
We analyzed the clinical features, prognostic factors, and survival of 66 male patients with primary mucosal melanoma on the glans penis, meatus, fossa navicularis, and distal urethra diagnosed over the past 25 years. Data from our series of 19 patients were combined with those of 47 patients reported in the literature.


RESULTS
The overall 2 and 5-year survival rates were 63% and 31%, respectively. All patients with nodal and/or distant metastases at presentation died within 2 years. Presence of ulceration, tumor depth of 3.5 mm or more, and tumor diameter greater than 15 mm had a significantly adverse effect on prognosis.


CONCLUSIONS
The prognosis of primary mucosal penile melanoma is not worse than that for cutaneous melanoma with comparable tumor thickness. Treatment should be similar to that for cutaneous melanoma, with wide radical excision and sentinel node biopsy in clinically lymph node-negative patients.
van Geel
Albertus N
AN
Department of Surgical Oncology, Erasmus Medical Center, Rotterdam, The Netherlands. a.n.vangeel@erasmusmc.nl
den Bakker
Michael A
MA
Kirkels
Wim
W
Horenblas
Simon
S
Kroon
Bin B R
BB
de Wilt
Johannes H W
JH
Eggermont
Alexander M M
AM
Mooi
Wolter J
WJ
van der Aa
Madelon N A
MN
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000401:mortality*; D008875:Middle Aged; D009426:Netherlands; D010412:Penile Neoplasms / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate