Fueling shivering thermogenesis during passive hypothermic recovery.
In humans, the relative importance of oxidative fuels for sustaining shivering during passive hypothermic recovery or rewarming is still unclear. The main goals of this study were 1) to quantify the respective contributions of lipids and carbohydrates (CHO) during passive rewarming and 2) to determine the effects of precooling exercise on the pattern of fuel utilization. With indirect calorimetry methodologies, changes in fuel metabolism were quantified in nonacclimatized adult men shivering to rewarm from moderate hypothermia (core temperature approximately 34.5 degrees C) not following (Con) or following a precooling exercise at 75% (.)Vo(2max) for 15 min (Pre-CE). As hypothermic individuals shiver to normothermia, results showed that CHO dominate at all shivering intensities above 50% Shiv(peak,) while lipids were preferred at lower intensities. This change in the relative importance of CHO and lipids to total heat production was dictated entirely by modulating CHO oxidation rate, which decreased by as much as 10-fold from the beginning to the end of rewarming (from 1,611 +/- 396 to 141 +/- 361 mg/min for Con and 1,555 +/- 230 to 207 +/- 261 mg/min for Pre-CE). In contrast, lipid oxidation rate remained constant and low (relatively to maximal rates at exercise) throughout rewarming, averaging 183 +/- 141 for Con and 207 +/- 118 mg lipids/min for Pre-CE. In addition, this pattern of fuel selection remained the same between treatments. We concluded that fuel selection is regulated entirely by changes in CHO oxidation rate. Further research should focus on establishing the exact regulatory processes involved in achieving this large upregulation of CHO utilization rate following hypothermia.
Haman
François
F
Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5. fhaman@uottawa.ca
Scott
Chris G
CG
Kenny
Glen P
GP
D000328:Adult; D001481:Basal Metabolism / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology*; D050260:Carbohydrate Metabolism / Q000502:physiology*; D015444:Exercise / Q000502:physiology; D006801:Humans; D007036:Hypothermia, Induced; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D010084:Oxidation-Reduction; D017694:Rewarming; D012768:Shivering / Q000502:physiology*