Cutaneous aspergillosis as a first manifestation of systemic infection in allogeneic haematopoietic stem cell transplantation.
Infections are one of the major causes of morbidity and mortality after stem cell transplantation (SCT). Opportunistic infections of varying severity with bacterial fungal and viral organisms occur in > 90% of patients after allogeneic SCT. Fatal opportunistic infections have been reported in 4-15% of related transplant recipients and 12-28% of unrelated transplant recipients. More than half of the transplant patients affected by invasive aspergillosis die despite treatment. Cutaneous aspergillosis has been rarely reported in transplant patients. During last five years 154 patients underwent allo SCT at our centre for various haematological disorders. Aspergillus infection was observed in six patients. Three patients had systemic aspergillosis whereas other three patients had primary cutaneous aspergillus infection. Patients with primary cutaneous aspergillosis are presented here as case report.
Hashmi
Khalil Ullah
KU
Departments of Haematology, Armed Forces Bone Marrow Transplant Centre, Rawalpindi.
Ahmed
Parvez
P
Satti
Tariq Mahmood
TM
Raza
Shahid
S
Chaudhry
Qama-un-Nissa
QU
Ikram
Aamer
A
Kamal
Muhammad Khalid
MK
Akhtar
Farrukh Mahmood
FM
D000328:Adult; D001228:Aspergillosis / Q000209:etiology* / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D002648:Child; D003881:Dermatomycoses / Q000209:etiology* / Q000382:microbiology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009894:Opportunistic Infections / Q000209:etiology* / Q000382:microbiology; D014184:Transplantation, Homologous