title: Metabolic syndrome, psychological status and quality of life in obesity: the QUOVADIS Study.
abstract: OBJECTIVE
  We aimed to investigate the association of the clinical variables of the metabolic syndrome (MS) and psychological parameters on health-related quality of life (HRQL) in obesity. In particular, our aim was to investigate the relative impact of physical symptoms, somatic diseases and psychological distress on both the physical and the mental domains of HRQL.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  A cohort of 1822 obese outpatients seeking treatment in medical centers.
  
  
  METHODS
  HRQL was measured by the standardized summary scores for physical (PCS) and mental (MCS) components of the Short Form 36 Health Survey (SF-36). Patients were grouped according to tertiles of PCS and MCS. Metabolic and psychological profiles of PCS and MCS tertiles were compared by discriminant analysis.
  
  
  RESULTS
  The profile of metabolic and psychological variables was tertile-specific in 62.4 and 68.3% of patients in the lowest and highest tertiles of PCS, respectively, while concordance was low in the mid-tertile (32.8%). Concordance was very high in the lowest (74.4%) and in the highest (75.5%) tertiles of MCS, and was fair in the mid-tertile (53.2%). The main correlates of PCS were obesity-specific and general psychological well-being, BMI, body uneasiness, binge eating, gender and psychiatric distress. Only hypertension and hyperglycemia qualified as correlates among the components of MS. The components of MS did not define MCS.
  
  
  CONCLUSIONS
  Psychological well-being is the most important correlate of HRQL in obesity, both in the physical and in the mental domains, whereas the features of MS correlate only to some extent with the physical domain of HRQL.
authors.affiliation: Department of Internal Medicine, University of Messina, Messina, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Corica
authors.forename: A
authors.initials: A
authors.lastname: Corsonello
authors.forename: G
authors.initials: G
authors.lastname: Apolone
authors.forename: E
authors.initials: E
authors.lastname: Mannucci
authors.forename: M
authors.initials: M
authors.lastname: Lucchetti
authors.forename: C
authors.initials: C
authors.lastname: Bonfiglio
authors.forename: N
authors.initials: N
authors.lastname: Melchionda
authors.forename: G
authors.initials: G
authors.lastname: Marchesini
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D001068:Feeding and Eating Disorders / Q000523:psychology; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000523:psychology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000523:psychology*; D011788:Quality of Life; D011795:Surveys and Questionnaires