[Single-lung transplantation for end-stage pulmonary parenchymal diseases with pulmonary hypertension].
OBJECTIVE
To observe the outcome of single-lung transplantation (SLT) for end-stage pulmonary parenchymal diseases in combination with pulmonary hypertension (PH).


METHODS
From September 2002 to November 2005, there were 22 lung transplantation recipients, suffering from emphysema (10/22), pulmonary fibrosis (10/22), pneumosilicosis (1/22) and vascular leiomyoma (1/22), and all of them were complicated with pulmonary hypertension to different extent. Operative techniques: 10 patients received left-lung transplantations, and 12 patients received right-lung transplantation. In all the patients echocardiography (ECHO) was performed before transplantation, and arterial blood was collected to determine oxygenation index (PaO(2)/FiO(2)).


RESULTS
The systolic pulmonary artery pressure (Ppa, syst) was monitored by Swan-Gans catheterization one week post-transplantation, and it was found to have decreased significantly [from (50.00+/-13.00) mm Hg (1 mm Hg=0.133 kPa) to (39.5+/-7.36) mm Hg,P<0.05]. Simultaneously, PaO(2)/FiO(2) was improved [from (241.26+/-79.54) mm Hg to (348.23+/-99.31) mm Hg, P<0.05].


CONCLUSIONS
Single lung transplantation is an efficient way to deal with end-stage pulmonary parenchymal disease combined with pulmonary hypertension.
Zhu
Yan-hong
YH
Lung Transplant Group, Wuxi Fifth Hospital, Wuxi Thoracic Hospital, Wuxi 214073, Jiangsu, China. zyh@wx5h.com
Chen
Jing-yu
JY
Zheng
Ming-feng
MF
Chang
Sheng
S
He
Yi-jun
YJ
Wang
Yong-gong
YG
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000503:physiopathology; D008171:Lung Diseases / Q000150:complications / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000150:complications / Q000601:surgery; D011658:Pulmonary Fibrosis / Q000150:complications / Q000601:surgery; D016896:Treatment Outcome