title: 'Should I stay or should I go?': myosin V function in organelle trafficking.
abstract: Actin- and microtubule-based motors can propel different cargos along filaments. Within cells, they control the distribution of membrane-bound compartments by performing complementary tasks. Organelles make long journeys along microtubules, with class V myosins ensuring their capture and their dispersal in actin-rich regions. Myosin Va is recruited on to diverse organelles, such as melanosomes and secretory vesicles, by a mechanism involving Rab GTPases. The role of myosin Va in the recruitment of secretory vesicles at the plasma membrane reveals that the cortical actin network cannot merely be seen as a physical barrier hindering vesicle access to release sites. In neurons, myosin Va controls the targeting of IP(3) (inositol 1,4,5-trisphosphate)-sensitive Ca(2+) stores to dendritic spines and the transport of mRNAs. These defects probably account for the severe neurological symptoms observed in Griscelli syndrome due to mutations in the MYO5A gene.
authors.affiliation: Institut de Biologie Physico-Chimique, Centre National de la Recherche Scientifique, UPR 1929, Université Paris 7 Denis Diderot, Paris, France. claire.desnos@ibpc.fr
authors.forename: Claire
authors.initials: C
authors.lastname: Desnos
authors.forename: Sébastien
authors.initials: S
authors.lastname: Huet
authors.forename: François
authors.initials: F
authors.lastname: Darchen
mesh_terms: D000818:Animals; D001692:Biological Transport; D006801:Humans; D020460:Melanosomes / Q000378:metabolism; D024701:Myosin Type V / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*; D022142:Secretory Vesicles / Q000378:metabolism
chemical_list: D024701:Myosin Type V