title: [Wound healing modulation in glaucoma surgery].
abstract: The wound healing response is one of the major determinants of filtering surgery success. Over the last two decades, antifibrotic agents, 5-fluorouracil (5-FU) and mitomycin C (MMC), have modified the prognosis of filtering surgery, particularly in patients at high risk for failure. Nevertheless, these agents are associated with severe complications. In order to maximize their benefits and minimize the rate of complications, the use of these powerful treatments has to be carefully evaluated in relation to patient risk factors for scarring. The choice of an antifibrotic agent, mode, dose and duration of application should be made with complete knowledge of the different effects of these treatments and adapted for each patient after an exhaustive preoperative evaluation.
authors.affiliation: Service d'Ophtalmologie III, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France. antoinelabbe@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Labbé
authors.forename: C
authors.initials: C
authors.lastname: Khammari
authors.forename: C
authors.initials: C
authors.lastname: Baudouin
mesh_terms: D000328:Adult; D000818:Animals; D002387:Cataract Extraction / Q000379:methods; D002648:Child; D002921:Cicatrix / Q000517:prevention & control*; D005128:Eye Diseases / Q000139:chemically induced / Q000517:prevention & control; D018463:Filtering Surgery; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D015316:Genetic Therapy; D005901:Glaucoma / Q000601:surgery*; D000882:Haplorhini; D006801:Humans; D016685:Mitomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D015337:Multicenter Studies as Topic; D011183:Postoperative Complications / Q000139:chemically induced / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D012307:Risk Factors; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D016685:Mitomycin; D005472:Fluorouracil