title: Amino acid uptake by kidney and jejunal tissue from dogs with cystine stones.
abstract: Cystine and lysine accumulation in vitro in intestinal and renal tissue was studied in eight dogs that form cystine stones. Under conditions which demonstrate in vitro defects in tissue obtained from humans with cystinuria, normal amino acid accumulation occurred in six dogs with the canine disorder. Normal amino acid uptake in tissue and the demonstration of normal to minimum increases in excretion of lysine suggest that the canine disorder is not similar to the human syndrome.
authors.affiliation: Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, Pennsylvania, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Holtzapple
authors.forename: K
authors.initials: K
authors.lastname: Bovee
authors.forename: C F
authors.initials: CF
authors.lastname: Rea
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D003553:Cystine / Q000378:metabolism; D003555:Cystinuria / Q000378:metabolism*; D004195:Disease Models, Animal; D004285:Dogs; D005998:Glycine / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism / Q000652:urine; D014545:Urinary Calculi / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D003553:Cystine; D008239:Lysine; D005998:Glycine