title: Overt and incomplete (silent) cerebral infarction in sickle cell anemia: diagnosis and management.
abstract: Cerebral vasculopathy in sickle cell anemia (HbSS) is manifest clinically as cerebral infarction and intracranial hemorrhage. The type of stroke, ischemic or hemorrhagic, is age specific with distinct differences in outcomes. Cerebral infarction with or without clinical stroke begins during early childhood and rarely causes death immediately.
authors.affiliation: Department of Pediatrics, Division of Hematology/Oncology, Children's Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Wing-Yen
authors.initials: WY
authors.lastname: Wong
authors.forename: Darleen R
authors.initials: DR
authors.lastname: Powars
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D001803:Blood Transfusion; D002544:Cerebral Infarction / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use
chemical_list: D006918:Hydroxyurea