title: Spotlight on autoimmune lymphoproliferative syndrome.
abstract: This month's Spotlight on... reviews autoimmune lymphoproliferative syndrome (ALPS) and its treatment. ALPS is an inherited disease caused by defects in lymphocyte apoptosis that cause nonmalignant proliferation of lymphocytes with autoimmune manifestations. Although there is yet no specific treatment for ALPS, therapies selectively targeting lymphocyte apoptosis may open a new avenue in the treatment of this rare disorder.
authors.affiliation: Prous Science, Barcelona, Spain. journals@prous.com
authors.forename: Elisa
authors.initials: E
authors.lastname: Ferrer
authors.forename: Maria Angels
authors.initials: MA
authors.lastname: Moral
authors.forename: Jordi
authors.initials: J
authors.lastname: Bozzo
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001327:Autoimmune Diseases / Q000473:pathology*; D053181:Caspase 8 / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008232:Lymphoproliferative Disorders / Q000473:pathology*; D008928:Mitochondria / Q000502:physiology
chemical_list: D053181:Caspase 8