title: [Antileishmanial activity of five 2- or 3- quinolines by enyne group].
abstract: BACKGROUND
  Leishmaniasis is an emergent orphan disease because of its co-infection with HIV AIDS. We report herein the in vitro biological evalution of five news quinolines, 2- or 3-substituted by an enyne group against Leishmania donovani (MHOM/ET/L82/LV9).
  
  
  METHODS
  The quinolines has been synthesized by using a cross-coupling reaction between a chloroenyne and an organometallic coumpound in a presence of iron a "green" catalyst. Biological evalution is realized by a colorimetric method with the use of 3-(4,5-diméthylthiazol-2,5-diphényl)-tetrazolium bromide.
  
  
  RESULTS
  Determination of the inhibitory concentrations as well as the minimal inhibitory concentrations has shown that the substitution by an enyne group made it possible to have a more important antileishmanial activity. In addition, we have seen that the -2 or the -3 position of the e nyne group h ad no influence in the antileishmanial activity.
  
  
  CONCLUSIONS
  Thus, we have shown the real interest of these quinolines which could be favourably compared with pentamidine, which is currently the reference p roduct, and to consider the use of these quinolines in the treament of the leishmaniasis.
authors.affiliation: Laboratoire de Chimie Organique et Thérapeutique, Faculté de Medecine de Pharmacie et d'Odonto-stomatologie, Université. matarsec@yahoo.fr
authors.forename: M
authors.initials: M
authors.lastname: Seck
authors.forename: J
authors.initials: J
authors.lastname: Desrivot
authors.forename: C
authors.initials: C
authors.lastname: Bories
authors.forename: P
authors.initials: P
authors.lastname: Loiseau
authors.forename: X
authors.initials: X
authors.lastname: Franck
authors.forename: R
authors.initials: R
authors.lastname: Hocquemiller
authors.forename: B
authors.initials: B
authors.lastname: Figadere
authors.forename: J F
authors.initials: JF
authors.lastname: Peyrat
authors.forename: O
authors.initials: O
authors.lastname: Provot
authors.forename: J D
authors.initials: JD
authors.lastname: Brion
authors.forename: M
authors.initials: M
authors.lastname: Alami
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D007893:Leishmania donovani / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests; D011804:Quinolines / Q000494:pharmacology*
chemical_list: D000981:Antiprotozoal Agents; D011804:Quinolines