title: Fournier's gangrene and its management at a tertiary care hospital.
abstract: OBJECTIVE
  To find the major causes of Fournier's gangrene and its management in a tertiary care hospital.
  
  
  METHODS
  A retrospective study was conducted at Department of Urology and Transplantation, JPMC, Karachi. Records of all patients with Fournier's Gangrene over 5 years' period i.e. from April 2001 till April 2006 were analysed.
  
  
  RESULTS
  The mean age was 48 years, all patients, presented with a delay of 2-16 days. Involvement was typical, with 70% extending to lower abdominal wall, and 10% to perianal region, while 37.5% were in septic shock. The cause of the gangrene was urological in 78.13%, followed by anorectal in 6.2% and idiopathic in 15.6%. Associated diseases were diabetes in 37.5%, uraemia in 12.5% and hepatic failure in 6.25%. Of all cases 12 died.
  
  
  CONCLUSIONS
  Aggressive surgical debridement with supportive measures is the main treatment. Twenty five percent patients died due to multiorgan failure in our study.
authors.affiliation: Department of Urology and Transplantation, Jinnah Postgraduate Medical Centre, Karachi.
authors.forename: Qazi
authors.initials: Q
authors.lastname: Fasih
authors.forename: Mubasher H
authors.initials: MH
authors.lastname: Turi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Akram
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003646:Debridement; D018934:Fournier Gangrene / Q000150:complications / Q000453:epidemiology / Q000209:etiology* / Q000601:surgery / Q000628:therapy*; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000382:microbiology; D010154:Pakistan / Q000453:epidemiology; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents