Quantitative assessment of microcollateral recruitment during coronary occlusion using real-time intravenous myocardial contrast echocardiography.
BACKGROUND
Residual collateral-derived myocardial blood flow (MBF) (A x beta) is important to protect against myocardial ischemia after acute coronary occlusion.


METHODS
Recruitment of microcollateral was assessed in 22 dogs with left circumflex coronary artery occlusion by analysis of MBF and regional wall thickening (WT) using real-time myocardial contrast echocardiography.


RESULTS
Video intensity and WT at the center of risk area were significantly lower than those at the border of risk area. The video intensity, A value, beta value, and MBF correlated well with WT after left circumflex coronary artery occlusion. The WT of the area with above 25% of normal MBF was preserved and was higher than that at below 25%. However, the deterioration of WT was not distinguished according to A value.


CONCLUSIONS
Real-time myocardial contrast echocardiography is a useful noninvasive method to evaluate collateral-derived MBF, which can be a reliable index of protection against myocardial ischemia.
Ishikura
Fuminobu
F
School of Allied Health Sciences, Osaka University, Faculty of Medicine, Osaka, Japan. ishikura@sahs.med.osaka-u.ac.jp
Otani
Kentaro
K
Kayano
Hiroyuki
H
Toshida
Tsutomu
T
Iwata
Akiko
A
Asanuma
Toshihiko
T
Kitakaze
Masafumi
M
Shinozaki
Yoshihiro
Y
Mori
Hidezo
H
Beppu
Shintaro
S
D000818:Animals; D003097:Collateral Circulation; D003287:Contrast Media; D003326:Coronary Circulation; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004195:Disease Models, Animal; D004285:Dogs; D015150:Echocardiography, Doppler; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006439:Hemodynamics / Q000502:physiology; D007262:Infusions, Intravenous; D016014:Linear Models; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000517:prevention & control; D011336:Probability; D012680:Sensitivity and Specificity
D003287:Contrast Media