title: Gold nanoparticle-based monitoring of the reduction of oxidized to reduced glutathione.
abstract: We demonstrate the reduction of oxidized to reduced glutathione in the presence of glutathione reductase enzyme based on the modulation in photoluminescent quenching efficiency between the perylene bisimide chromophore TPPCA and gold nanoparticles (AuNPs). The TPPCA-AuNPs assembly shows a turn-on fluorescent signal in the presence of reduced glutathione, which provides a new concept to measure the balance of glutathione in a creature.
authors.affiliation: Key Laboratory of Organic Solids, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beiijng 100080, P. R. China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: He
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Zhong
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Guo
authors.forename: Jing
authors.initials: J
authors.lastname: Lv
authors.forename: Jialiang
authors.initials: J
authors.lastname: Xu
authors.forename: Mei
authors.initials: M
authors.lastname: Zhu
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Li
authors.forename: Huibiao
authors.initials: H
authors.lastname: Liu
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.forename: Yulan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Daoben
authors.initials: D
authors.lastname: Zhu
mesh_terms: D005978:Glutathione / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013053:Spectrophotometry
chemical_list: D006046:Gold; D005978:Glutathione