Voxel-based morphometry of auditory and speech-related cortex in stutterers.
Stutterers demonstrate unique functional neural activation patterns during speech production, including reduced auditory activation, relative to nonstutterers. The extent to which these functional differences are accompanied by abnormal morphology of the brain in stutterers is unclear. This study examined the neuroanatomical differences in speech-related cortex between stutterers and nonstutterers using voxel-based morphometry. Results revealed significant differences in localized grey matter and white matter densities of left and right hemisphere regions involved in auditory processing and speech production.
Beal
Deryk S
DS
Department of Speech-Language Pathology, University of Toronto, Canada. d.beal@utoronto.ca
Gracco
Vincent L
VL
Lafaille
Sophie J
SJ
De Nil
Luc F
LF
D000328:Adult; D001303:Auditory Cortex / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology*; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009434:Neural Pathways / Q000473:pathology* / Q000503:physiopathology*; D013060:Speech; D013067:Speech Perception; D013342:Stuttering / Q000473:pathology* / Q000503:physiopathology*; D014705:Verbal Behavior