title: Histoplasma capsulatum fungemia in patients with acquired immunodeficiency syndrome: detection by lysis-centrifugation blood-culturing technique.
abstract: Progressive disseminated histoplasmosis (PDH) is an increasingly common cause of infection in patients with acquired immune deficiency syndrome (AIDS). We report 21 cases of PDH associated with AIDS diagnosed by lysis-centrifugation blood culture method. The most prevalent clinical findings were fever, weight loss, respiratory symptoms, and mucocutaneous lesions. Chest roentgenogram showed diffuse pulmonary infiltrates in 13 of 21 patients (62%). Bronchoalveolar fluid has yielded positive culture in four patients only in medium with cycloheximide.
authors.affiliation: PPG - Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Brazil.
authors.forename: Flávio de Mattos
authors.initials: Fde M
authors.lastname: Oliveira
authors.forename: Sérgio Sônego
authors.initials: SS
authors.lastname: Fernandes
authors.forename: Cecília Bittencourt
authors.initials: CB
authors.lastname: Severo
authors.forename: Luciana Silva
authors.initials: LS
authors.lastname: Guazzelli
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: Severo
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000382:microbiology; D000328:Adult; D002498:Centrifugation / Q000379:methods; D046508:Culture Techniques; D005260:Female; D016469:Fungemia / Q000175:diagnosis* / Q000382:microbiology; D006658:Histoplasma / Q000145:classification / Q000302:isolation & purification; D006660:Histoplasmosis / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D008297:Male