Neuronal migration: unraveling the molecular pathway with humans, mice, and a fungus.
This review highlights the utility of comparative genetics in understanding the molecular mechanisms that underlie neuronal migration. It is apparent from studies in humans, mice, and a fungus that nuclear migration is a key component of neuronal migration and that both are dependent on a dynamic microtubule network. In vertebrates regulation of this network involves a complex pathway that is dependent on extracellular guidance cues, membrane-bound receptors, intracellular signaling molecules, proteins associated with microtubules, and the components of microtubules themselves.
Keays
David A
DA
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK. keays@well.ox.ac.uk
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000235:genetics; D000818:Animals; D001233:Aspergillus nidulans / Q000166:cytology / Q000235:genetics*; D002465:Cell Movement / Q000235:genetics*; D002467:Cell Nucleus / Q000378:metabolism; D000089622:Doublecortin Domain Proteins; D006801:Humans; D051379:Mice / Q000235:genetics*; D008817:Mice, Mutant Strains; D008818:Mice, Neurologic Mutants; D008822:Mice, Transgenic; D008869:Microtubule-Associated Proteins / Q000235:genetics; D008954:Models, Biological; D009154:Mutation; D009474:Neurons / Q000166:cytology*; D009479:Neuropeptides / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*; D014404:Tubulin / Q000235:genetics
D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D014404:Tubulin; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C084102:PAFAH1B1 protein, human