title: DNA variation in MSR1, RNASEL and E-cadherin genes and prostate cancer in Poland.
abstract: BACKGROUND
  We investigated whether or not inherited variation in MSR1, RNASEL and E-cadherin contribute to prostate cancer risk in Poland.
  
  
  METHODS
  We sequenced the coding region of these three genes in individuals from Poland and identified five common DNA variants (R462Q and D541E in RNASEL, R293X and P275A in MSR1, and 2076C>T (A692A) in E-cadherin). These five variants and the -160C>A promoter change in E-cadherin were genotyped in 737 prostate cancer cases and 511 controls.
  
  
  RESULTS
  The frequencies of genotyped variants in MSR1, RNASEL and E-cadherin genes in cases and controls were similar. We did not see any association for the studied variants when cases were stratified by age of diagnosis, by family history, by prostate-specific antigen level at the time of diagnosis, by Gleason sore or by tumor stage.
  
  
  CONCLUSIONS
  Inherited variation in RNASEL, MSR1 and E-cadherin genes do not seem to contribute to prostate cancer development in Poland.
authors.affiliation: International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Cezary
authors.initials: C
authors.lastname: Cybulski
authors.forename: Dominika
authors.initials: D
authors.lastname: Wokołorczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Gliniewicz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sikorski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Huzarski
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Debniak
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D004722:Endoribonucleases / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D051117:Scavenger Receptors, Class A / Q000235:genetics*
chemical_list: D015820:Cadherins; D004273:DNA, Neoplasm; C495139:MSR1 protein, human; D051117:Scavenger Receptors, Class A; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease