title: Ossifying fibromyxoid tumor of soft parts with clonal chromosomal aberrations.
abstract: Ossifying fibromyxoid tumor (OFMT) is a rare but morphologically distinctive soft-tissue tumor. The histologic origin of this tumor is not clearly known, but its various features suggest a schwannian, neuronal, or chondroid origin. We herein report a case of a typical OFMT that occurred in the shoulder of a 65-year-old man. The karyotype exhibited the following complex numeric and structural aberrations: 42 approximately 46,XY,-Y,add(1)(q42),add(6)(p21),t(10;18)(q26;q11),der(11)t(11;15)(q23;q15),add(12)(q13),ins(14;?)(q13;?),-15,+mar. Combined with several previously reported studies, these aberrations could not identify a common cytogenetic abnormality in OFMT.
authors.affiliation: Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510 Japan. inskawa@med.niigata-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawashima
authors.forename: Akira
authors.initials: A
authors.lastname: Ogose
authors.forename: Hajime
authors.initials: H
authors.lastname: Umezu
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hotta
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tohyama
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsuchiya
authors.forename: Naoto
authors.initials: N
authors.lastname: Endo
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D002879:Chromosomes, Human, Pair 10; D002887:Chromosomes, Human, Pair 18; D002999:Clone Cells; D020732:Cytogenetic Analysis; D005350:Fibroma / Q000235:genetics*; D020440:Gene Duplication; D006801:Humans; D008297:Male; D009999:Ossification, Heterotopic / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics*