title: [Maxillar osteonecrosis associated with bisphosphonate treatment and dental implants].
abstract: BACKGROUND
  Bisphosphosnates are reference products used to treat osteoporosis, malignant bone disease, Paget's disease, and hypercalcemia. However these drugs seem to induce osteonecrosis of the jaws. This osteonecrosis is frequently observed and must be evoked in patients presenting with oral ulceration under bisphosphonate therapy.
  
  
  METHODS
  We report the case of a long-term fully dental implanted patient treated by bisphosphonates who presented a maxillar ostenecrosis with no previous radiotherapy.
  
  
  CONCLUSIONS
  The risk factors and mechanism of this induced osteonecrosis are described. But could long term osseo-integrated dental implants be a triggering factor?
authors.affiliation: Service d'ORL et de chirurgie maxillofaciale, hôpital Pasteur, 30, avenue de la Voie-Romaine, 06002 Nice cedex 01, France. csavoldelli@yahoo.fr
authors.forename: C
authors.initials: C
authors.lastname: Savoldelli
authors.forename: F
authors.initials: F
authors.lastname: Le Page
authors.forename: J
authors.initials: J
authors.lastname: Santini
authors.forename: G
authors.initials: G
authors.lastname: Scortecci
authors.forename: G
authors.initials: G
authors.lastname: Odin
mesh_terms: D000196:Actinomycosis / Q000175:diagnosis; D000368:Aged; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D015921:Dental Implants / Q000009:adverse effects; D004164:Diphosphonates / Q000009:adverse effects*; D005882:Gingival Diseases / Q000382:microbiology; D006801:Humans; D008297:Male; D008439:Maxillary Diseases / Q000139:chemically induced*; D019226:Oral Ulcer / Q000382:microbiology; D010020:Osteonecrosis / Q000139:chemically induced*
chemical_list: D050071:Bone Density Conservation Agents; D015921:Dental Implants; D004164:Diphosphonates