Catalytic stereoselective synthesis of highly substituted indanones via tandem Nazarov cyclization and electrophilic fluorination trapping.
A new catalytic stereoselective tandem transformation via Nazarov cyclization/electrophilic fluorination has been accomplished. This sequence is efficiently catalyzed by a Cu(II) complex to afford fluorine-containing 1-indanone derivatives with two new stereocenters with high diastereoselectivity (trans/cis up to 49/1). Three examples of catalytic enantioselective tandem transformation are presented.
Nie
Jing
J
Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China.
Zhu
Hong-Wei
HW
Cui
Han-Feng
HF
Hua
Ming-Qing
MQ
Ma
Jun-An
JA