title: [The possible effect of ampicillin treatment in preventing preterm birth].
abstract: OBJECTIVE
  To study the possible association between oral ampicillin treatment during pregnancy and pregnancy complications, in addition delivery outcomes, particularly preterm birth.
  
  
  METHODS
  The authors evaluated the so-called control newborn infants without congenital abnormalities in the population based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities.
  
  
  RESULTS
  Of 38,151 newborn infants, 2630 (6.9 %) had mothers with ampicillin treatment during pregnancy. Some pregnancy complications, particularly preeclampsia showed a higher prevalence in pregnant women with ampicillin treatment. Mean gestational age was slightly longer but it resulted in a significant reduction in the prevalence of preterm birth (7.1% vs 9.3 %; adjusted POR with 95 degrees % CI: 0.8, 0.7-0.9). The preterm birth preventive effect of ampicillin was most obvious after the use of the drug in the first trimester of pregnancy. Similar difference was not seen in the reduction of low birth weight.
  
  
  CONCLUSIONS
  Ampicillin treatment, particularly in the first trimester of gestation can reduce the proportion of preterm birth in pregnant women with acute infectious diseases.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar II. Szülészeti és Nogyógyászati Klinika Budapest. kazydoki@t-online.hu
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Kazy
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Puhó
authors.forename: Endre
authors.initials: E
authors.lastname: Czeizel
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D006814:Hungary; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D047928:Premature Birth / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D000667:Ampicillin