title: Smoking and aortic diseases.
abstract: Cigarette smoking is a major vascular risk factor and in this context, it is an independent risk factor for the development of aortic disease, especially the formation and growth of abdominal aortic aneurysms (AAA). Medline was searched up to January 31, 2007 for the relevant literature for this review of the mechanisms by which smoking causes aortic wall damage and its subsequent impact on the clinical manifestation of this process. Idiopathic AAAs and aortic dissection are considered, as well as other aortic diseases (eg, Takayasu, Kawasaki, Behcet and Buerger). There is evidence suggesting an abnormal homeostasis between proteolytic and antiproteolytic activity in the vascular wall during the development of AAAs, and these mechanisms can be influenced by smoking. Smoking cessation plays an important role in the management of aortic disease.
authors.affiliation: Department of Clinical Biochemistry, Royal Free Hospital, Royal Free and University College Medical School, London, UK.
authors.forename: A I
authors.initials: AI
authors.lastname: Kakafika
authors.forename: D P
authors.initials: DP
authors.lastname: Mikhailidis
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000201:enzymology / Q000209:etiology; D001018:Aortic Diseases / Q000209:etiology* / Q000473:pathology; D004730:Endothelium, Vascular / Q000201:enzymology / Q000473:pathology; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects*
chemical_list: D010447:Peptide Hydrolases