title: Relationship between (99m)Tc-GSA scintigraphic indices of liver function reserve and portal circulation in patients with chronic liver disease.
abstract: OBJECTIVE
  In order to predict the prognosis or complications of portal hypertension in patients with chronic liver disease, it is important to evaluate both hepatic functional reserve and portal circulation. On (99m)Tc-galactosyl human serum albumin ((99m)Tc-GSA) scintigraphy, the index of blood clearance (HH15) and receptor index (LHL15) have been widely used to evaluate the hepatic functional reserve. However, the relationship between these indices and portal circulation is unknown. The purpose of this study was to examine the relationship between HH15 and LHL15 and portosystemic shunts evaluated with arteriographic portography or esophagogastroduodenoscopy.
  
  
  METHODS
  A total of 82 patients with chronic liver disease (mean age, 66.7 years) who underwent (99m)Tc-GSA scintigraphy, arteriographic portography, and esophagogastroduodenoscopy were enrolled. HH15 and LHL15 were obtained from dynamic (99m)Tc-GSA scintigraphy. The patients were divided into three groups according to the arteriographic portography findings: group 1, no portal collateral circulation; group 2, mild collateral development; and group 3, moderate to severe collateral development. They were also divided into three groups based on the esophagogastroduodenoscopic findings: group A, no varices; group B, small-caliber varices; and group C, enlarged varices. The Kruskal-Wallis test was used to compare each index among these groups. Receiver operating characteristic (ROC) analysis was used to determine whether each index was an indicator for the presence of portosystemic shunts.
  
  
  RESULTS
  Both HH15 and LHL15 differed significantly between groups 1 and 2 and between groups 1 and 3. However, only HH15 differed significantly between groups A and B and between groups A and C. On the basis of the ROC analysis, the HH15 threshold value of 0.62 yielded both excellent sensitivity (83.9%) and specificity (84.6%) for the presence of portosystemic shunts, as evaluated with arteriographic portography. The HH15 threshold value of 0.64 yielded both good sensitivity (66.1%) and specificity (69.2%) for the presence of portosystemic shunts, as evaluated with esophagogastroduodenoscopy, whereas no adequate threshold value of LHL15 was found for the presence of portosystemic shunts.
  
  
  CONCLUSIONS
  HH15 is a potent indicator of the presence of portosystemic shunts in chronic liver disease.
authors.affiliation: Department of Radiology, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Japan. osada@saitama-med.ac.jp
authors.forename: Hisato
authors.initials: H
authors.lastname: Osada
authors.forename: Norinari
authors.initials: N
authors.lastname: Honda
authors.forename: Takeo
authors.initials: T
authors.lastname: Takahashi
authors.forename: Shinya
authors.initials: S
authors.lastname: Oku
authors.forename: Atsushi
authors.initials: A
authors.lastname: Abe
authors.forename: Wataru
authors.initials: W
authors.lastname: Watanabe
authors.forename: Takemichi
authors.initials: T
authors.lastname: Okada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohno
authors.forename: Mikito
authors.initials: M
authors.lastname: Hondo
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Nishimura
mesh_terms: D000368:Aged; D000792:Angiography / Q000379:methods; D004724:Endoscopy; D005189:False Positive Reactions; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D008111:Liver Function Tests / Q000379:methods*; D008875:Middle Aged; D011170:Portasystemic Shunt, Surgical; D012372:ROC Curve; D011877:Radionuclide Imaging / Q000295:instrumentation / Q000379:methods; D019275:Radiopharmaceuticals / Q000494:pharmacology*; D013668:Technetium Tc 99m Aggregated Albumin / Q000737:chemistry*; D016284:Technetium Tc 99m Pentetate / Q000737:chemistry*
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D016284:Technetium Tc 99m Pentetate