Genetic factors in the pathogenesis of UV-induced skin cancer1.
UV light exposure has been incriminated for the steady rise in skin cancer incidence observed during the last years. However, individual responses to the oncogenic effects of UV light are greatly variable. Among the many factors modulating the response to UV light, genetic variations play a pivotal role. This review examines major progress in our understanding of major hereditary and nonhereditary genetic modifiers involved in the pathogenesis of UV-induced skin cancer.
Sprecher
Eli
E
Laboratory of Molecular Dermatology, Department of Dermatology, Rambam Medical Center, Haifa, Israel.
D002280:Basal Cell Carcinoma / Q000209:etiology / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008545:Melanoma / Q000209:etiology / Q000235:genetics; D012878:Skin Neoplasms / Q000209:etiology* / Q000235:genetics*; D014466:Ultraviolet Rays / Q000009:adverse effects*