title: A novel binuclear palladium complex with benzothiazole-2-thiolate: synthesis, crystal structure and interaction with DNA.
abstract: The novel Pd(II) complex, [Pd(2)(micro-bzta)(4)].1.5DMSO (where bzta=benzothiazole-2-thiolate) has been synthesized and structurally characterized by element analysis, IR and single-crystal X-ray diffractometry. In the binuclear complex, two palladium(II) are bridged by four deprotonated benzothiazole-2-thialate in a head to tail disposition and the distance of the two Pd(II) is 2.747 A. Three-dimensional structure of the complex was constructed though S...S (3.339 A) weak interaction and pi...pi stack. The binding of the title complex with fish sperm DNA (FS-DNA) has been investigated by absorption and fluorescence spectra. The results indicate that the complex bind to FS-DNA in an intercalative mode and the intrinsic binding constant K of the title complex with FS-DNA is about 1.2 x 10(4)M(-1). Gel electrophoresis assay demonstrates the ability of the complex to cleave the pUC19 plasmid DNA.
authors.affiliation: Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang 110142, China. ejgao@yahoo.com.cn
authors.forename: En-Jun
authors.initials: EJ
authors.lastname: Gao
authors.forename: Ke-Hua
authors.initials: KH
authors.lastname: Wang
authors.forename: Xiao-Fu
authors.initials: XF
authors.lastname: Gu
authors.forename: Ying
authors.initials: Y
authors.lastname: Yu
authors.forename: Ya-Guang
authors.initials: YG
authors.lastname: Sun
authors.forename: Wang-Zhong
authors.initials: WZ
authors.lastname: Zhang
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Yin
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Ming-Chang
authors.initials: MC
authors.lastname: Zhu
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Yan
mesh_terms: D000818:Animals; D052160:Benzothiazoles / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D004587:Electrophoresis, Agar Gel; D005399:Fishes; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D052160:Benzothiazoles; D010165:Palladium; D004247:DNA