A new dihydroagarofuranoid sesquiterpene from Microtropis fokienensis with antituberculosis activity.
A new dihydroagarofuran-based sesquiterpene, 8-acetoxymutangin (1), was isolated from the stems of Microtropis fokienensis, together with eight known compounds, including mutangin (2). Their structures were determined through in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 1 exhibited potent in vitro antituberculosis activity, with an MIC value of 10.0 microg/ml against Mycobacterium tuberculosis 90-221387, which is considerably better than that of mutangin (2). The activity of 1 lies in the same range as that of the clinic drug ethambutol (MIC 6.25 microg/ml), despite completely different chemical structures, which indicates different modes of action.
Chou
Tsung-Hsien
TH
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
Chen
Ih-Sheng
IS
Sung
Ping-Jyun
PJ
Peng
Chien-Fang
CF
Shieh
Po-Chuen
PC
Chen
Jih-Jung
JJ
D000995:Antitubercular Agents / Q000302:isolation & purification* / Q000494:pharmacology; D029753:Celastraceae; D008826:Microbial Sensitivity Tests / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D000995:Antitubercular Agents; D010936:Plant Extracts; D012717:Sesquiterpenes; C079978:dihydroagarofuran