title: [Expression of inducible nitric oxide synthase in cartilage in progression of temporomandibular joint osteoarthritis].
abstract: OBJECTIVE
  To study the expression of inducible nitric oxide synthase (iNOS) in cartilage of temporomandibular joint osteoarthriti (TMJOA), and to evaluate the role of iNOS in the progression of TMJOA.
  
  
  METHODS
  The goats were used and TMJOA was induced by injection of collagenase in upper joint space. The joints were obtained and were investigated by using immunohistochemistry at 2, 4, 12, 24 weeks after injection.
  
  
  RESULTS
  Almost no expression of iNOS in normal cartilage of TMJ. In the diseased joints, strong or definite iNOS reactivity was expressed.
  
  
  CONCLUSIONS
  iNOS plays an important role in the progression of TMJOA.
authors.affiliation: Dept. of Plastic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Zhan-Wei
authors.initials: ZW
authors.lastname: Gao
authors.forename: Da-Zhang
authors.initials: DZ
authors.lastname: Wang
authors.forename: Bao-Lin
authors.initials: BL
authors.lastname: Liu
authors.forename: Hai-Huan
authors.initials: HH
authors.lastname: Ma
mesh_terms: D002356:Cartilage; D006801:Humans; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D010003:Osteoarthritis; D013704:Temporomandibular Joint
chemical_list: C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II