Association analysis of G72/G30 polymorphisms with schizophrenia in the Korean population.
Several studies examining the association between G72/G30 polymorphisms and schizophrenia in cohorts of various ethnic origins have recently been reported. The aim of the current study was to examine the genetic influence of the G72/G30 polymorphisms in the Korean population. Nine G72/G30 single-nucleotide polymorphisms (SNPs) were genotyped in 388 patients with schizophrenia and 367 normal controls from the Korean population. Based on statistical analyses, the positive associations of previous studies of other populations were not replicated in the present study. However, 2 of the 9 tested SNPs, rs778294 and rs947267, were found to be associated with the risk of schizophrenia after correction for multiple testing (P(cor)=0.03 and P(cor)=0.04, respectively). The rs778294 SNP, taken singly, had not been found to be associated with schizophrenia in previous studies, and the second SNP, rs947267, showed an opposite direction of genetic effect on schizophrenia risk here than in a previous study. Our association results were not consistent with those found in other populations, and, thus could be chance findings. Therefore, further studies with larger sample sizes are needed to confirm a risk allele for this gene if it exists.
Shin
Hyoung Doo
HD
Department of Genetic Epidemiology, SNP Genetics Inc., Seoul, Republic of Korea.
Park
Byung Lae
BL
Kim
Eun Mi
EM
Lee
Soo Ok
SO
Cheong
Hyun Sub
HS
Lee
Chang Hee
CH
Kim
Shin Gyeom
SG
Sohn
Jin-Wook
JW
Park
Chul Soo
CS
Kim
Jae Won
JW
Kim
Byung Hyo
BH
Kim
Im-Yel
IY
Choi
Ihn-Geun
IG
Woo
Sung-Il
SI
D044466:Asian People / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D015331:Cohort Studies; D005787:Gene Frequency; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007723:Korea; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger; D012559:Schizophrenia / Q000235:genetics*
D002352:Carrier Proteins; C475071:DAOA protein, human; C488199:DAOAAS gene product, human; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D012333:RNA, Messenger