Synthesis and inhibitory activity of new benzimidazole derivatives against Burkitt's lymphoma promotion.
As a continuation to our previous work concerning antitumor benzimidazoles, we have synthesized series of new derivatives of 2-(1-benzyl-2-methyl-1H-benzimidazol-5-ylimino)-3-(substituted)-thiazolidin-4-one (6a-e), 3-(2-methyl-1H-benzimidazol-5-yl)-2-substituted-thiazolidin-4-one (9a-f) and we have studied their inhibitory activity against the Epstein-Barr virus-early antigen (EBV-EA) activation introduced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Compound 6d was found to be significantly active and compounds 5a and 6e were also active.
Ramla
Mostafa M
MM
Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Cairo, Egypt. mostafa_ramla@yahoo.com
Omar
Mohamed A
MA
Tokuda
H
H
El-Diwani
Hoda I
HI
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D002051:Burkitt Lymphoma / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007097:Imines / Q000737:chemistry; D009829:Oleic Acids / Q000737:chemistry; D010703:Phorbol Esters / Q000737:chemistry; D013329:Structure-Activity Relationship; D045162:Thiazolidinediones / Q000737:chemistry; D014407:Tumor Cells, Cultured; D014775:Virus Activation / Q000187:drug effects*
D000998:Antiviral Agents; D001562:Benzimidazoles; D007097:Imines; D009829:Oleic Acids; D010703:Phorbol Esters; D045162:Thiazolidinediones; C050164:phorbol 13-monoacetate; C002446:12-octadecenoic acid