Liver cancer risk, coffee, and hepatitis C virus infection: a nested case-control study in Japan.
We examined hepatocellular carcinoma mortality in relation to coffee consumption and anti-hepatitis C virus (HCV) antibody seropositivity in a nested case-control study involving 96 cases. The multivariate-adjusted odds ratios (95% confidence interval) for daily coffee drinkers vs non-drinkers were 0.49 (0.25-0.96), 0.31 (0.11-0.85), and 0.75 (0.29-1.92) in all cases, in HCV-positive and in HCV-negative individuals, respectively.
Wakai
K
K
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. wakai@med.nagoya-u.ac.jp
Kurozawa
Y
Y
Shibata
A
A
Fujita
Y
Y
Kotani
K
K
Ogimoto
I
I
Naito
M
M
Nishio
K
K
Suzuki
H
H
Yoshimura
T
T
Tamakoshi
A
A
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003069:Coffee; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007564:Japan; D008113:Liver Neoplasms / Q000150:complications*; D008875:Middle Aged; D012307:Risk Factors
D003069:Coffee