TiCl4-catalyzed indirect anti-Markovnikov hydration of alkynes: application to the synthesis of benzo[b]furans.
An efficient methodology for the indirect anti-Markovnikov hydration of unsymmetrically substituted terminal and internal alkynes is based on TiCl4-catalyzed hydroamination reactions. Its application to ortho-alkynylhaloarenes, followed by a copper-catalyzed O-arylation, provides flexible access to substituted benzo[b]furans.
Ackermann
Lutz
L
Institut für Organische und Biomolekulare Chemie, Georg-August-Universitaet Goettingen, Tammannstrasse 2, D-37077 Goettingen, Germany. Lutz.Ackermann@chemie.uni-goettingen.de
Kaspar
Ludwig T
LT