title: Gamma-herpesviruses and cellular signaling in AIDS-associated malignancies.
abstract: gamma-Herpesviruses, Epstein-Barr virus (EBV/HHV-4) and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), are involved in human carcinogenesis, particularly in immunocompromised patients. Virus-associated malignancies are becoming of significant concern for the mortality of long-lived immunocompromised patients, and therefore, research of advanced strategies for AIDS-related malignancies is an important field in cancer chemotherapy. Detailed understanding of the EBV and KSHV lifecycle and related cancers at the molecular level is required for novel strategies of molecular-targeted cancer chemotherapy. The present review gives a simple outline of the functional interactions between KSHV- and EBV-viral gene products and host cell deregulated signaling pathways as possible targets of chemotherapy against AIDS-related malignancies.
authors.affiliation: Department of Bioactive Molecules, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
authors.forename: Kohji
authors.initials: K
authors.lastname: Noguchi
authors.forename: Hidesuke
authors.initials: H
authors.lastname: Fukazawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Murakami
authors.forename: Naoko
authors.initials: N
authors.lastname: Takahashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamagoe
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Uehara
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D012514:Sarcoma, Kaposi / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*