Pharmacology, pharmacokinetics and pharmacogenomics of paclitaxel.
Paclitaxel is widely used in many cancers including ovarian, breast, lung, head and neck and primary unknown. Paclitaxel is extensively metabolized by cytochrome P450s and excreted in bile. The cytochromes involved include 2C8 and 3A4. This is a review of the pharmacokinetics, pharmacodynamics, drug interactions, metabolism and pharmacogenomics of paclitaxel.
Steed
Helen
H
University of Alberta, Department of Gyne-oncology, Department of Obstetrics and Gynecology, Cross Cancer Institute, Edmonton, Alberta, Canada.
Sawyer
Michael B
MB
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics / Q000627:therapeutic use / Q000633:toxicity; D001711:Biotransformation; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006207:Half-Life; D006801:Humans; D023421:Models, Animal; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics; D017239:Paclitaxel / Q000493:pharmacokinetics* / Q000627:therapeutic use* / Q000633:toxicity; D010597:Pharmacogenetics / Q000379:methods; D051381:Rats
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel