Chuktabularins A-D, four new limonoids with unprecedented carbon skeletons from the stem bark of Chukrasia tabularis.
Chuktabularins A-D (1-4), four novel 16-norphragmalin-type limonoids that feature unprecedented skeletons with a biosynthetically extended C2 or C3 unit at C-15 forming a unique 2,7-dioxabicyclo[2.2.1]heptane moiety, were isolated from the stem bark of Chukrasia tabularis. Their structures were elucidated by spectroscopic analysis and computer modeling. The biosynthetic pathway of 1-4 was postulated.
Zhang
Chuan-Rui
CR
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Yang
Sheng-Ping
SP
Liao
Shang-Gao
SG
Fan
Cheng-Qi
CQ
Wu
Yan
Y
Yue
Jian-Min
JM
D053898:Biosynthetic Pathways; D036701:Limonins / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*
D036701:Limonins