[Therapeutic effect of liver transplantation on acute liver failure].
OBJECTIVE
To evaluate the short-term and long-term outcomes of emergent liver transplantation recipients with acute liver failure and to identify factors that influenced these outcomes.


METHODS
318 consecutive patients who underwent liver transplantations between January 2001 and December 2004 were analyzed retrospectively (all the cases were followed up to December 2005). According to UNOS grading scale, all recipients preoperative status were evaluated. 54 patients were acute liver failure (Group I, UNOS 1 and 2A), and the other 264 cases were chronic liver diseases (Group II, UNOS 2B and 3). The postoperative effects in different groups were compared, including the survival rates, incidences of complications, rates and causes of retransplantation, rates and causes of death.


RESULTS
Comparing UNOS2B/3 to UNOS1/2A, the perioperative mortality were 3.7%; 22.6%, the rate of complications 16.7%; 55.6%, 1 year survival rate 91.3%; 74.1%, 3 year survival rate 86.4%; 68.5%, the retransplantation rate 1.1%; 18.5% respectively.


CONCLUSIONS
Since the technique of liver transplant is very advanced, the effect of surgery is mainly depended on the function of liver and other organs in patients. The recipients with UNOS2B/3 have better short-term and long-term outcomes as comparing to UNOS1/2A. In addition, the recipients with UNOS1/2A are burdened with much higher mortality.
Peng
Zhi-hai
ZH
General surgery department of the first people's hospital affiliated to Shanghai Jiaotong University, Shanghai 200080, China.
Xing
Tong-hai
TH
Dai
De-jian
DJ
Chen
Guo-qing
GQ
Xu
Jun-ming
JM
Zhong
Lin
L
Li
Tao
T
Sun
Xing
X
Wang
Shu-yun
SY
Wang
Zhao-wen
ZW
D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D017114:Liver Failure, Acute / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D012092:Replantation; D012189:Retrospective Studies; D015996:Survival Rate