[Prospects for using combined three-dimensional injection of gel transplants with autologous and allogenic cell cultures in reproductive medicine].
A combined cellular transplant for injection has been designed, by using lowly differentiated stromal fat tissue cells obtained from Wistar rats and it preserved biological and physical properties after passing through a small-diameter injection needle (an insulin syringe). A morphological study of the results of its transplantation into paraurethral tissues in 28 female rats showed that the transplant cells, autologous ones in particular, activated the proliferation of local connective tissue cell populations and retained their viability and proliferative and synthetic activities up 20 days or more. At the end of the experiment (on days 27-35), marked focal connective tissue enlargement at the site of injection of both allo- and autografts results in the narrowing of the urethral lumen. The injection implantation of combined allo- and autografts opens up new avenues for the treatment of pathological processes of the reproductive and urinary tracts.
Adamian
L V
LV
Zaĭrat'iants
O V
OV
Gol'dshteĭn
D V
DV
Volkov
A V
AV
Makarov
A V
AV
Rzhaninova
A A
AA
Opalenov
K V
KV
Iarotskaia
E L
EL
Bychenko
A B
AB
Smolina
T Iu
TIu
Arutiunian
I V
IV
D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D005260:Female; D005782:Gels / Q000008:administration & dosage* / Q000737:chemistry; D007267:Injections / Q000295:instrumentation; D051381:Rats; D017208:Rats, Wistar; D033581:Stem Cell Transplantation / Q000379:methods*; D017154:Stromal Cells / Q000637:transplantation*; D013594:Syringes; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014521:Urethra / Q000166:cytology / Q000601:surgery
D005782:Gels