Adverse cutaneous drug reactions: clinical pattern and causative agents in a tertiary care center in South India.
BACKGROUND
Adverse cutaneous drug reactions (ACDRs) are caused by a wide variety of agents.


OBJECTIVE
Our objective was to ascertain the clinical spectrum of ACDRs and the causative drugs in this part of India and to find any risk factors.


METHODS
Ninety patients with adverse cutaneous drug reactions were recruited for this study during 2001-2003. Hematological and biochemical investigations were done in all of them. The VDRL and HIV (ELISA) tests were performed where the underlying risk factors were present. Patch testing, intradermal testing and oral provocation tests were done wherever feasible.


RESULTS
The mean age of the patients with cutaneous drug eruptions was 37.06 years. Most of them (52.2%) were in the age group of 20-39 years. The male to female ratio was 0.87: 1. The most common eruptions observed were fixed drug eruption (31.1%) and maculopapular rash (12.2%), and the most common causes were co-trimoxazole (22.2%) and dapsone (17.7%).


CONCLUSIONS
The pattern of ACDRs and the drugs causing them is remarkably different in our population. Knowledge of these drug eruptions, the causative drugs and the prognostic indicators is essential for the clinician.
Pudukadan
David
D
Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry-605006.
Thappa
Devinder Mohan
DM