[Effects of series of Muskone on heart hemodynamics and myocardial consumption of oxygen in experimental dogs].
OBJECTIVE
To observe the effects of series of Muskone (the muskone includes Slender Dutchmanspipe Root, Inula Root and neither kind of Common Aucklandia Root) on the heart hemodynamics and myocardial consumption of oxygen in experimental dogs, and to explain its pharmacological action on cardiovascular system.


METHODS
Arterial blood pressure, coronary blood flow, resistance in coronary artery, total peripheral resistance, work of left artrium and oxygen consumption index of the cardiac muscles were observed in anaesthetic dogs.


RESULTS
The series of Muskone decreased arterial blood pressure significantly, dilated coronary artery and peripheral arteries significantly, increased coronary blood flow, decreased resistance in coronary artery, improved the work of left artrium, the oxygen availability of cardiac muscles and the complaisance of arteries in cardiac muscles.
Zhang
Yong-Tao
YT
Xiyuan Hospital, China Academy of Chinese Medicine Sciences, Beijing 100091, China.
Ma
Kun
K
Zhang
Jin-Yan
JY
Li
Yi-Kui
YK
Wu
Li-Mao
LM
Li
Xiang-Ri
XR
Pan
Li
L
Gao
Hi-Li
HL
Li
Lian-Da
LD
D000818:Animals; D030022:Aristolochia / Q000737:chemistry; D019659:Asteraceae / Q000737:chemistry; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D003516:Cycloparaffins / Q000302:isolation & purification / Q000494:pharmacology*; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects*; D038143:Inula / Q000737:chemistry; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D014655:Vascular Resistance / Q000187:drug effects
D003516:Cycloparaffins; D004338:Drug Combinations; C031021:muscone