Gliosarcoma with melanocytic differentiation.
We present an unusual case of gliosarcoma containing numerous islands of well-differentiated melanocytes in a 65 year-old man. Melanocytic differentiation of medulloblastomas is well described, and it has also rarely been reported in low-grade glial neoplasms. Histologic features and immunophenotyping are helpful in differentiating divergent differentiation in a gliosarcoma from melanoma. To our knowledge, this is the first description of a gliosarcoma with melanocytic differentiation. Awareness of the phenomenon of melanocytic differentiation within primary neuroepithelial and glial neoplasms is important to prevent the misdiagnosis of these tumors such as metastatic melanoma or primary melanocytic neoplasms of the CNS.
Dulai
Mohanpal S
MS
Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA.
Moes
Gregory S
GS
Briley
Anita L
AL
Galperin
Ilana B
IB
Smyth
Lawrence
L
Cherry
Athena M
AM
Lehman
Norman L
NL
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D003937:Diagnosis, Differential; D018316:Gliosarcoma / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008279:Magnetic Resonance Imaging; D008297:Male; D008544:Melanocytes / Q000648:ultrastructure*; D008545:Melanoma / Q000473:pathology; D046529:Microscopy, Electron, Transmission
D014408:Biomarkers, Tumor