Anti-anaphylactic effect of Euphorbia hirta.
The Euphorbia hirta ethanolic extract (EH A001) was found to possess a prominent anti-anaphylactic activity. A preventive effect of EH-A001 given by oral route at dose from 100 to 1000 mg/kg was observed against compound 48/80-induced systemic anaphylaxis. At the same range of dose, EH-A001 inhibited passive cutaneous anaphylaxis (PCA) in rat and active paw anaphylaxis in mice. A suppressive effect of EH-A001 was observed on the release of TNF-alpha and IL-6 from anti-DNP-HSA activated rat peritoneal mast cells.
Youssouf
M S
MS
Division of Pharmacology and Natural Product Chemistry, Indian Institute of Integrative Medicine, Jammu-Tawi, India. msyousf@rediffmail.com
Kaiser
P
P
Tahir
M
M
Singh
G D
GD
Singh
S
S
Sharma
V K
VK
Satti
N K
NK
Haque
S E
SE
Johri
R K
RK
D000284:Administration, Oral; D000707:Anaphylaxis / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D028481:Euphorbia; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D015850:Interleukin-6 / Q000096:biosynthesis; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis; D010537:Peritoneum / Q000166:cytology; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D003189:p-Methoxy-N-methylphenethylamine
D006634:Histamine H1 Antagonists; D015850:Interleukin-6; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D003189:p-Methoxy-N-methylphenethylamine