Dysautonomia, fibromyalgia and reflex dystrophy.
Autonomic nervous system dysfunction observed in fibromyalgia, characterized without exception by a sympathetic hyperactivity and hyporeactivity, has been reported. However, several studies demonstrated reduced levels of norepinephrine and neuropeptide Y at rest and after tilt table in some patients, which was improved by beta-stimulating agents. These findings support heterogeneity in fibromyalgia-associated dysautonomia. Fibromyalgia could be a generalized sympathetic dystrophy since both conditions are activated by trauma and partly linked to sympathetic mechanisms. Yet they differ on several points: hormonal and neurochemical abnormalities are observed in fibromyalgia whereas activation by peripheral trauma and hyperosteolysis are observed in reflex sympathetic dystrophy.
Eisinger
Jean
J
D001342:Autonomic Nervous System Diseases / Q000097:blood / Q000503:physiopathology*; D005356:Fibromyalgia / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D009478:Neuropeptide Y / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D012019:Reflex Sympathetic Dystrophy / Q000097:blood / Q000503:physiopathology*; D018667:Tilt-Table Test
D009478:Neuropeptide Y; D009638:Norepinephrine