title: Influence of body mass index on prognosis of Japanese patients with renal cell carcinoma.
abstract: OBJECTIVE
  Obesity, a significant risk factor for renal cell carcinoma (RCC), has recently become a public health problem in Japan. In addition, the incidence of RCC in Japan has steadily increased during the past few decades. The objective of the present study was to investigate the relationship of body mass index (BMI) to the prognosis of Japanese patients with RCC.
  
  
  METHODS
  From January 1991 to December 2002, 270 operations for RCC in 269 consecutive Japanese patients were performed at our institution. BMI data were available for 264 (98%) of the 269 patients. Overall, cancer-specific, and recurrence-free survival were investigated using the Kaplan-Meier method, and the Cox regression model was used to determine the significant prognostic factors on multivariate analysis.
  
  
  RESULTS
  Of the 264 patients, 140 (53.0%), 67 (25.4%), and 57 (21.6%) had a BMI of less than 23, 23 to 25, and greater than 25 kg/m2, respectively. These three BMI groups were not significantly different in age, sex, presenting symptoms, tumor stage, or grade. On univariate analysis, a significant advantage regarding overall and cancer-specific, but not recurrence-free, survival was found for patients with a BMI of 23 kg/m2 or greater compared with those with a BMI of less than 23 kg/m2. Also, on multivariate analysis, the BMI was significantly associated with overall and cancer-specific, but not recurrence-free, survival.
  
  
  CONCLUSIONS
  Our findings suggest that a BMI of 23 kg/m2 or more favorably affects the prognosis of Japanese patients with RCC. However, additional studies are needed to verify these results.
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Awakura
authors.forename: Eijiro
authors.initials: E
authors.lastname: Nakamura
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ito
authors.forename: Toshinari
authors.initials: T
authors.lastname: Yamasaki
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kamba
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kamoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
mesh_terms: D015992:Body Mass Index; D002292:Carcinoma, Renal Cell / Q000401:mortality* / Q000601:surgery; D005260:Female; D006801:Humans; D007564:Japan; D007680:Kidney Neoplasms / Q000401:mortality* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate