title: N,N'-ditosylhydrazine: a convenient reagent for facile synthesis of diazoacetates.
abstract: A novel entry to the synthesis of diazoacetates is disclosed. A variety of diazoacetates were synthesized from the corresponding bromoacetates by treatment with N,N'-ditosylhydrazine in moderate to high yields. Ease of operation with the stable crystalline reagent as well as a short reaction time offer a useful alternative to the conventional methods.
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Toma
authors.forename: Jun
authors.initials: J
authors.lastname: Shimokawa
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D000085:Acetates / Q000138:chemical synthesis*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003979:Diazonium Compounds / Q000138:chemical synthesis*; D006834:Hydrazines / Q000737:chemistry*; D007202:Indicators and Reagents; D015394:Molecular Structure; D014105:Tosyl Compounds / Q000737:chemistry*
chemical_list: D000085:Acetates; D003979:Diazonium Compounds; D006834:Hydrazines; D007202:Indicators and Reagents; D014105:Tosyl Compounds