title: [Protective effect of hypothermia on brain neurons of rats exposed to ionizing radiation].
abstract: The conditions of the protein-synthesizing system in neurons of the hippocampus (areas CA1 and C A3) and of the cortex (sensomotor region) in rats subjected to y-irradiation at a dose of 8 Gy under hypothermia (16 - 18 degrees C) and hypoxia-hypercapnia were investigated by fluorescent and electron microscopy. Under hypothermia, the protein-synthesizing system was shown to be damaged to a lesser degree and to be restored faster in comparison with similar neurons in rats irradiated at room temperature. In rats irradiated under hypothermia, the rRNA biogenesis and the protein-synthesizing activity of polyribosomes were restored in two days. The protective influence of hypothermia did not spread to changes in membrane structures (endoplasmic reticulum and Golgy apparatus); i.e., a partial loss of integrity and possible transformation of their structure caused by the irradiation and the restoration of these structures occurred at a lower rate.
authors.forename: R Ia
authors.initials: RIa
authors.lastname: Gordon
authors.forename: D A
authors.initials: DA
authors.lastname: Ignat'ev
authors.forename: E B
authors.initials: EB
authors.lastname: Mel'nikova
authors.forename: V V
authors.initials: VV
authors.lastname: Rogachevskiĭ
authors.forename: I V
authors.initials: IV
authors.lastname: Kraev
authors.forename: S S
authors.initials: SS
authors.lastname: Hutsian
mesh_terms: D000818:Animals; D001921:Brain / Q000528:radiation effects* / Q000648:ultrastructure; D007036:Hypothermia, Induced; D008297:Male; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000378:metabolism / Q000528:radiation effects* / Q000648:ultrastructure; D014176:Protein Biosynthesis / Q000528:radiation effects; D011832:Radiation Injuries / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar