title: Prophylactic platelet transfusion in children with thrombocytopenic disorders: a retrospective review.
abstract: The safety of low platelet thresholds for prophylactic transfusions was retrospectively evaluated in 673 children with various thrombocytopenic disorders. In patients with idiopathic thrombocytopenic purpura and X linked thrombocytopenia the threshold for the use of platelet transfusion was based on bleeding events rather than platelet count. In children with hypoproliferative thrombocytopenia and Wiskott-Aldrich syndrome, prophylactic platelet transfusions were used when the platelet count was <or= 5000/microl in stable patients and > 10,000/microl in cases of bleeding or infections. The restrictive policy of platelet transfusions was shown to be proved safe in many thrombocytopenic disorders.
authors.affiliation: Department of Pediatrics, The 2nd University of Naples, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Ferrara
authors.forename: L
authors.initials: L
authors.lastname: Capozzi
authors.forename: A
authors.initials: A
authors.lastname: Coppola
authors.forename: G
authors.initials: G
authors.lastname: Save
authors.forename: L
authors.initials: L
authors.lastname: Coppola
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000150:complications / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005199:Fanconi Anemia / Q000150:complications / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D040181:Genetic Diseases, X-Linked / Q000150:complications / Q000628:therapy; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008297:Male; D010976:Platelet Count / Q000706:statistics & numerical data; D017713:Platelet Transfusion / Q000009:adverse effects / Q000706:statistics & numerical data; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000628:therapy; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000209:etiology / Q000235:genetics / Q000628:therapy*; D014923:Wiskott-Aldrich Syndrome / Q000150:complications / Q000628:therapy*