title: [Prostatic carcinoma that arose with hearing loss: a case report].
abstract: A 69-year-old male with tinnitus, vertigo, and progressive hearing loss of left ear was admitted to our hospital. Head magnetic resonance imaging and computed tomography (CT) revealed swelling of multiple neck lymph nodes (LNs) invading the skull base, which involved left mastoid sinus/the eighth cranial nerve. Biopsy of the cervical LN demonstrated small-cell carcinoma (SCC). Whole body CT showed systemic lymphadenopathies (subclavian, para-aortic, and bilateral iliac LNs) and prostatic swelling with multiple pelvic masses. Needle biopsy of the prostate revealed SCC (Gleason score: 5+ 5). Immunohistochemically, neuron-specific enolase (NSE) and NCAM were detected in <10% and -100% of cancer cells, respectively. Despite SCC histology, prostate-specific antigen (PSA) and androgen receptor (AR) were also expressed in -20% and -70% of tumor cells, respectively. Serum PSA and NSE were 464 ng/ml and 12 ng/ml, respectively. After maximum androgen blockade (MAB) with leuprorelin/bicalutamide, the patient showed recovery of hearing loss, regression of cervical LNs (partial response), and decline of serum markers (PSA 7.38 ng/ml and NSE 3.7 ng/ml, respectively). As re-increase of PSA was observed after ten months, MAB menu was changed to leuprorelin/fultamide. Another four months later, the treatment was changed to docetaxel/ estramustine due to the appearance of systemic bone pain and recurrence of LN metastases. He is alive (39 months after diagnosis) with cancer. Widespread metastases at the time of diagnosis were compatible with SCC. However, this case was AR-positive and responded to androgen ablation, at least temporarily. Even though the initial symptoms are atypical for a prostatic carcinoma, SCC of prostate needs to be included as a rare differential diagnosis.
authors.affiliation: Department of Clinical Pathology, Osaka Rosai Hospital.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Sakuma
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yoshida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohashi
authors.forename: Kensaku
authors.initials: K
authors.lastname: Nishimura
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kawano
mesh_terms: D000368:Aged; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D046088:Hearing Loss, Unilateral / Q000209:etiology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D011471:Prostatic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D011944:Receptors, Androgen / Q000032:analysis
chemical_list: D011944:Receptors, Androgen