[Significance of histological signs of chronic HBV and HCV infections in the differential diagnosis of chronic hepatitis].
100 inpatients with chronic hepatitis, mainly with mild hepatitis, underwent serological, histological, and immunohistochemical studies for markers of HBV and HCV infections. The histological features of HBV and HCV infections coincided with serological and immunohistochemical findings. The histological and immunohistochemical features of HBV- and HBV+HCV infection were found in 48.3% patients with chronic hepatitis of unknown etiology. Immunohistochemical studies considerably increased the efficiency of establishing HBV+HCV infection as compared with serological diagnosis. Multivariate statistic methods were used to construct a model of the differential diagnosis of chronic hepatitis B and C based on the most important histological features, the predictive value was 87.7%.
Solov'eva
T S
TS
D000911:Antibodies, Monoclonal / Q000032:analysis / Q000097:blood; D003937:Diagnosis, Differential; D016174:Hepacivirus / Q000302:isolation & purification*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000302:isolation & purification*; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D018936:Hepatitis C Antigens / Q000032:analysis; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology / Q000821:virology; D011237:Predictive Value of Tests; D017361:Viral Nonstructural Proteins / Q000032:analysis
D000911:Antibodies, Monoclonal; D006514:Hepatitis B Surface Antigens; D018936:Hepatitis C Antigens; C093542:NS4 protein, hepatitis C virus; D017361:Viral Nonstructural Proteins