title: Success of MRSA eradication in hospital routine: depends on compliance.
abstract: BACKGROUND
  To prevent transmission of MRSA, eradication by antiseptic washings and nasal ointment is recommended. There are few studies, which investigated the success of eradication of MRSA carriage during everyday clinical working conditions and results are controversial. We wanted to assess the effectiveness of MRSA eradication procedures--especially octenidine whole body washings and mupirocin nasal ointment--under conditions of everyday life.
  
  
  METHODS
  We retrospectively analyzed the files of all patients who were admitted to the medical department of a tertiary care hospital between 1999 and 2004 and who were infected or colonized by MRSA. According to hospital's standards of care patients should have been washed with octenidine and should have got mupirocin nasal ointment only in case of nasal carriage. Patients were regarded as MRSA-eradicated when swabs taken on three consecutive days, earliest, three days after discontinuation of antiseptic and antiinfective procedures were without proof of MRSA.
  
  
  RESULTS
  Only 6% of patients were eradicated. MRSA could be cultured from swabs taken on dismissal of 60% of patients. Fifteen percent of patients had only one or two negative series of swabs. In 19% of patients success of eradication remained unknown. Besides we found that under every day clinical working conditions compliance with several tasks of the eradication protocol was insufficient.
  
  
  CONCLUSIONS
  Under every day clinical working conditions MRSA eradication is successful only in few patients. Whole body washings should be tested in detailed studies before they should become a recommendation for eradication of MRSA.
authors.affiliation: Hospital Hygiene, University Hospital Essen, Hufelandstr. 55, 45122 Essen, Germany. dorothea.hansen@uk-essen.de
authors.forename: D
authors.initials: D
authors.lastname: Hansen
authors.forename: P-I
authors.initials: PI
authors.lastname: Patzke
authors.forename: U
authors.initials: U
authors.lastname: Werfel
authors.forename: D
authors.initials: D
authors.lastname: Benner
authors.forename: A
authors.initials: A
authors.lastname: Brauksiepe
authors.forename: W
authors.initials: W
authors.lastname: Popp
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D001494:Baths / Q000379:methods; D002353:Carrier State / Q000188:drug therapy*; D019091:Critical Pathways; D003428:Cross Infection / Q000517:prevention & control*; D003666:Decontamination / Q000379:methods; D004203:Disinfection / Q000379:methods*; D005260:Female; D005858:Germany; D019983:Guideline Adherence; D006785:Hospitals, University; D006801:Humans; D007097:Imines; D017053:Infection Control / Q000379:methods; D008297:Male; D016106:Methicillin Resistance / Q000187:drug effects*; D008875:Middle Aged; D016712:Mupirocin / Q000008:administration & dosage; D011725:Pyridines / Q000627:therapeutic use; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000891:Anti-Infective Agents, Local; D007097:Imines; D011725:Pyridines; D016712:Mupirocin; C034213:octenidine