title: [Cognitive deficits in bipolar disorder].
abstract: Bipolar disorders are often associated with cognitive deficits which have an influence on social functioning and the course of the illness. These deficits have an impact on occupational ability and social integration. To date, specific cognitive domains have been found which characterize bipolar affective disorders. However, there is evidence of stable and lasting cognitive impairment in all phases of the disorder, including the remission phase, in the following domains: sustained attention, memory and executive functions (e.g. cognitive flexibility and problem solving). Although their cognitive deficits are comparable the deficits in patients with schizophrenia are more severe than those with bipolar disorder. Recent brain imaging findings indicate structural and functional abnormalities in the cortical and limbic networks of the brain in patients with bipolar disorder compared to healthy controls. Mood stabilizer and atypical antipsychotics may reduce cognitive deficits in certain domains (e.g. executive functions and word fluency) and may have a positive effect on quality of life and social functioning.
authors.affiliation: Medizinische Universität Wien, Universitätsklinik für Psychiatrie und Psychotherapie, Klinische Abteilung für Sozialpsychiatrie. gabriele.sachs@meduniwien.ac.at
authors.forename: Gabriele
authors.initials: G
authors.lastname: Sachs
authors.forename: Markus
authors.initials: M
authors.lastname: Schaffer
authors.forename: Bernadette
authors.initials: B
authors.lastname: Winklbaur
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D018692:Antimanic Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D002540:Cerebral Cortex / Q000473:pathology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D003937:Diagnosis, Differential; D006801:Humans; D008032:Limbic System / Q000473:pathology; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000175:diagnosis
chemical_list: D000927:Anticonvulsants; D018692:Antimanic Agents; D014150:Antipsychotic Agents