title: [Mucoepidermoid carcinoma of the parotid gland as a secondary malignancy developed ten years after chemotherapy for childhood acute lymphoblastic leukemia].
abstract: We report on a case of mucoepidermoid carcinoma of the parotid gland following treatment of acute lymphoblastic leukemia (ALL) in childhood. The female patient was diagnosed as having T-cell ALL at the age of 13 years. Treatment included multidrug chemotherapy and prophylactic 18 Gy cranial irradiation. She developed low-grade mucoepidermoid carcinoma of the right parotid gland at the age of 24 years, the most probable cause of the secondary malignancy being radiation. In a literature review of mucoepidermoid carcinoma following ALL, 11 out of 14 cases received radiation therapy for the initial treatment of ALL, but 3 cases had no radiation therapy. The parotid gland carcinoma as a secondary malignancy following ALL in childhood is rare, but it highlights the need for concern about the secondary malignancy in patients with painless parotid swelling after chemoradiotherapy.
authors.affiliation: Department of Pediatrics, Anjo Kosei Hospital.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Miyatima
authors.forename: Akimasa
authors.initials: A
authors.lastname: Ogawa
authors.forename: Kuniyosi
authors.initials: K
authors.lastname: Kuno
authors.forename: Kosuke
authors.initials: K
authors.lastname: Toda
authors.forename: Keisuke
authors.initials: K
authors.lastname: Suzuki
authors.forename: Akiharu
authors.initials: A
authors.lastname: Mituya
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D018277:Carcinoma, Mucoepidermoid / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects; D013601:T-Lymphocytes; D013997:Time Factors; D016896:Treatment Outcome