Biphenotypic bigenotypic lymphoma with simultaneous expression of PAX5/BSAP and B- and T-cell markers.
Lymphomas are currently categorized according to their origin from a B or T lymphocyte. Immature and less commonly mature (peripheral) lymphomas may harbor rearrangements of both the B- and T-cell antigen receptor genes (dual genotype or bigenotype). Rarely, cells in lymphoma with a single genotype simultaneously express both B- and T-cell markers (biphenotypic lymphomas). We discuss the diagnostic and clinical implications in the case of a 42-yr-old female with a peripheral CD30+ lymphoma that displayed both characteristic B- and T-cell surface antigens and clonal rearrangement of B- and T-cell antigen receptor gene loci. Simultaneous nuclear expression of the transcription factor gene PAX5 suggested that this major driver of B-cell differentiation did not preclude expression of CD3epsilon, generally assumed to be a T-cell associated antigen.
Hansson
Markus
M
Department of Hematology, Lund University Hospital, Lund, Sweden. markus.hansson@med.lu.se
Jerkeman
Mats
M
Dictor
Michael
M
D000328:Adult; D001402:B-Lymphocytes / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D051757:PAX5 Transcription Factor / Q000378:metabolism*; D010641:Phenotype; D013601:T-Lymphocytes / Q000378:metabolism*
D014408:Biomarkers, Tumor; D051757:PAX5 Transcription Factor