title: Significance of lymphatic invasion and proliferation on regional lymph node metastasis in renal cell carcinoma.
abstract: We studied the associations of lymphatic invasion and lymphatic vessel density around tumors with lymph node (LN) status in renal cell carcinoma (RCC) by immunohistochemical analysis using D2-40 antibody as a lymphatic marker. Surgically removed specimens from 76 cases with RCC, including 16 cases with LN metastasis, were used. Lymphatic vessel density around the tumor increased compared with normal kidneys but was not significant by LN status. Tumor size, tumor cell types, patterns of tumor growth, nuclear grade of tumor cells, venous invasion, lymphatic invasion, and primary tumor stage were predictive factors for LN metastasis. Based on multivariate regression analysis, only lymphatic invasion was an independent risk factor for LN metastasis. The immunohistochemical detection of lymphatics was useful for identifying the lymphatic invasion of RCC, and the presence of lymphatic invasion around RCC was an independent predictive factor for LN metastasis.
authors.affiliation: Department of Pathology, Toho University School of Medicine, Tokyo, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Aida
authors.forename: Seiichi
authors.initials: S
authors.lastname: Tamai
authors.forename: Yoshikiyo
authors.initials: Y
authors.lastname: Akasaka
authors.forename: Hideko
authors.initials: H
authors.lastname: Kiguchi
authors.forename: Yuri
authors.initials: Y
authors.lastname: Akishima-Fukasawa
authors.forename: Masamichi
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Soh
authors.forename: Kinji
authors.initials: K
authors.lastname: Ito
authors.forename: Masayo
authors.initials: M
authors.lastname: Kimura-Matsumoto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Ishiguro
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nishimura
authors.forename: Itaru
authors.initials: I
authors.lastname: Kamata
authors.forename: Reiko
authors.initials: R
authors.lastname: Shimokawa
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Ishii
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D058846:Antibodies, Monoclonal, Murine-Derived; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D042582:Vascular Endothelial Growth Factor C / Q000032:analysis
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D042582:Vascular Endothelial Growth Factor C; C500987:monoclonal antibody D2-40