title: [A case of advanced pancreatic cancer successfully treated by combined chemotherapy of S-1 and gemcitabine as second-line chemotherapy].
abstract: The patient was a 63-year-old man who suffered from advanced pancreatic cancer (T 4 N 3 M 0, Stage IVb). Palliative operation was performed for obstructive jaundice. He was treated with chemotherapy of gemcitabine (GEM) alone as first-line, and combined chemotherapy of GEM and S-1 as second-line. Both therapies were effective for this patient. Tumor marker (CA 19-9) decreased after chemotherapies (first-line: 5,692 U/mL to 70 U/mL, second-line: 4,877 U/mL to 562 U/mL). No toxic events were observed due to these therapies, so he was treated as an outpatient for about 2 years. It was considered that he had a good quality of life.
authors.affiliation: Dept. of Surgery, Kurashiki Central Hospital.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kawamoto
authors.forename: Kazushige
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Michio
authors.initials: M
authors.lastname: Okabe
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tsuruta
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Mototaka
authors.initials: M
authors.lastname: Niwano
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sano
authors.forename: Tebun
authors.initials: T
authors.lastname: Paku
authors.forename: Shiro
authors.initials: S
authors.lastname: Imai
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ito
authors.forename: Keizo
authors.initials: K
authors.lastname: Ogasahara
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004334:Drug Administration Schedule; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011788:Quality of Life; D005641:Tegafur / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D000093542:Gemcitabine
chemical_list: D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000093542:Gemcitabine