A new cytotoxic carbazole alkaloid from Clausena excavata.
A new carbazole alkaloid, 3-carbomethoxy-2-hydroxy-7-methoxycarbazole, Clausine-TY (1), together with two known carbazole alkaloid, Clausine-H (2) and Clausine-B (3), were isolated from the ethyl acetate extract of the stem bark of the Malaysian Clausena excavata. The structures of these compounds were elucidated by spectroscopic analyses. The new carbazole alkaloid shows significant cytotoxicity against CEM-SS cell line.
Taufiq-Yap
Y H
YH
Department of Chemistry, Universiti Putra Malaysia, Selangor, Malaysia. yap@fsas.upm.edu.my
Peh
T H
TH
Ee
G C L
GC
Rahmani
M
M
Sukari
M A
MA
Ali
A M
AM
Muse
R
R
D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D006575:Heterocyclic Compounds, 3-Ring / Q000302:isolation & purification / Q000627:therapeutic use; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D027821:Rutaceae / Q000737:chemistry*
D002227:Carbazoles; D006575:Heterocyclic Compounds, 3-Ring; C506702:clausine H; C523721:clausine-B; C523722:clausine-TY