Group reorientation and migration of amphiphilic polymer bearing phosphorylcholine functionalities on surface of cellular membrane mimicking coating.
Amphiphilic polymers bearing phosphorylcholine (PC) groups can form films of interfacial structure similar to that of the outer membrane of living cells. The films, as prepared, present PC groups to the external aqueous environment and exhibit good biocompatibility. However, under certain conditions, the surface structure can change irreversibly due to the reorientation and deep migration of the surface groups. X-ray photoelectron spectroscopy (XPS), dynamic contact angle measurements, and cell culture experiments were used to investigate the reorientation and migration of the surface groups of an amphiphilic PC-polymer coating. When the polymer surface is immersed into or drawn out of water, significant reorientation and group migration occurs, as suggested by the large difference between the advancing and receding contact angles. Angle-resolved XPS measurements indicate that the hydrophobic groups move to the air/film interface while the hydrophilic groups migrate towards the bulk of the polymer coating. Long periods of aging may result in irreversible changes of the surface structure and decrease the biocompatibility of the materials.
Yang
Shan
S
Department of Chemistry, Northwest University, Xi'an 710069, China.
Zhang
Shi-Ping
SP
Winnik
Françoise M
FM
Mwale
Fackson
F
Gong
Yong-Kuan
YK
D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D010767:Phosphorylcholine / Q000737:chemistry / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D013501:Surface-Active Agents / Q000737:chemistry / Q000378:metabolism*; D020298:U937 Cells
D001672:Biocompatible Materials; D011108:Polymers; D013501:Surface-Active Agents; D010767:Phosphorylcholine