WITHDRAWN: Bromocriptine for unexplained subfertility in women.
BACKGROUND
Bromocriptine improves hyperprolactinemic amenorrhea and so could also be helpful in the treatment of unexplained subfertility in women.


OBJECTIVE
To assess the effects of bromocriptine in women with unexplained subfertility.


METHODS
The Cochrane Subfertility Review Group specialised register of controlled trials was searched.


METHODS
Randomised trials comparing bromocriptine with placebo or no treatment in women with unexplained subfertility.


METHODS
Two reviewers applied the eligibility criteria and assessed trial quality independently.


RESULTS
Three trials involving of 127 women were included. All trials were double-blind comparisons with placebo, and one was of crossover design. Conception rates with bromocriptine treatment did not improve compared with placebo (odds ratio was 1.12, 95% confidence interval 0.48 to 2.57).


CONCLUSIONS
There is not enough evidence to evaluate bromocriptine use in women with unexplained subfertility. However trials for women with unexplained subfertility who also have expressible galactorrhea may be worthwhile.
Hughes
E
E
McMaster University, Rm HSC-4F7, Dept of Obstetrics & Gynecol, 1200 Main St West, Hamilton, Ontario, Canada, L8N 3Z5. hughese@mcmaster.ca
Collins
J
J
Vandekerckhove
P
P
D001971:Bromocriptine / Q000627:therapeutic use*; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*
D006727:Hormone Antagonists; D001971:Bromocriptine