Synthesis of macrocyclic shellfish toxins containing spiroimine moieties.
An overview of the structure and biological activity of macrocyclic polyketides derived from dinoflagellates that contain unusual cyclic imine units is provided. The total and partial syntheses of these molecules are discussed with an emphasis on the construction of the spiroimine functionality thought to be the key pharmacophore of these fact-acting shellfish toxins.
O'Connor
Patrick D
PD
Department of Chemistry, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
Brimble
Margaret A
MA
D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D008387:Marine Toxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D012758:Shellfish
D018942:Macrolides; D008387:Marine Toxins