title: The use of the antifungal agent miconazole as an inhibitor of Blastocystis hominis growth in Entamoeba histolytica/E. dispar cultures.
abstract: In regions with high prevalence, Blastocystis hominis is frequently found in association with Entamoeba histolytica/E. dispar in xenic cultures. Its exacerbated growth is often superimposed on the growth of amebas, thus impeding the continuation of the amebas in the culture, within a few generations. The present study reports on the excellent efficacy (100%) of the antifungal agent miconazole in eliminating B. hominis from cultures of E. histolytica/E. dispar, thereby maintaining the integrity of the trophozoites of the amebas. Nystatin presented low efficacy (33.3%).
authors.affiliation: Laboratório de Doenças Parasitárias, Departamento de Medicina Tropical, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil. queiroga@ioc.fiocruz.br
authors.forename: Alessandra Queiroga
authors.initials: AQ
authors.lastname: Gonçalves
authors.forename: João da Costa
authors.initials: Jda C
authors.lastname: Viana
authors.forename: Edna Maria
authors.initials: EM
authors.lastname: Pires
authors.forename: Márcio Neves
authors.initials: MN
authors.lastname: Bóia
authors.forename: José Rodrigues
authors.initials: JR
authors.lastname: Coura
authors.forename: Edward Félix
authors.initials: EF
authors.lastname: Silva
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D016845:Blastocystis hominis / Q000187:drug effects*; D003470:Culture Media; D004747:Entamoeba / Q000254:growth & development*; D004748:Entamoeba histolytica / Q000254:growth & development; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D008825:Miconazole