The ins and outs of phosphate homeostasis.
A complication of chronic renal failure is hyperphosphatemia. An apparently straightforward manipulation to treat this--restriction of dietary phosphate--has proven that phosphate homeostasis is more complicated than we currently understand. This Commentary describes recent findings on novel regulatory factors that contribute to phosphate homeostasis.
Nemere
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Department of Nutrition and Food Sciences, Utah State University, Logan, Utah 84322-8700, USA. Nemere@cc.usu.edu
D000818:Animals; D002117:Calcitriol; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors; D006706:Homeostasis; D006801:Humans; D017674:Hypophosphatemia / Q000188:drug therapy / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy; D053858:Metabolic Networks and Pathways; D010710:Phosphates / Q000502:physiology* / Q000627:therapeutic use
D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002117:Calcitriol