title: Nasal saline irrigations for the symptoms of chronic rhinosinusitis.
abstract: BACKGROUND
  The use of nasal irrigation for the treatment of nose and sinus complaints has its foundations in yogic and homeopathic traditions. There has been increasing use of saline irrigation, douches, sprays and rinsing as an adjunct to the medical management of chronic rhinosinusitis. Treatment strategies often include the use of topical saline from once to more than four times a day. Considerable patient effort is often involved. Any additional benefit has been difficult to discern from other treatments.
  
  
  OBJECTIVE
  To evaluate the effectiveness and safety of topical saline in the management of chronic rhinosinusitis.
  
  
  METHODS
  Our search included the Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 4 2006), MEDLINE (1950 to 2006) and EMBASE (1974 to 2006). The date of the last search was November 2006.
  
  
  METHODS
  Randomised controlled trials in which saline was evaluated in comparison with either no treatment, a placebo, as an adjunct to other treatments or against treatments. The comparison of hypertonic versus isotonic solutions was also compared.
  
  
  METHODS
  Trials were graded for methodological quality using the Cochrane approach (modification of Chalmers 1990). Only symptom scores from saline versus no treatment and symptom and radiological scores from the hypertonic versus isotonic group could be pooled for statistical analysis. A narrative overview of the remaining results is presented.
  
  
  RESULTS
  Eight trials were identified that satisfied the inclusion criteria. Three studies compared topical saline against no treatment, one against placebo, one as an adjunct to and one against an intranasal steroid spray. Two studies compared different hypertonic solutions against isotonic saline. There is evidence that saline is beneficial in the treatment of the symptoms of chronic rhinosinusitis when used as the sole modality of treatment. Evidence also exists in favour of saline as a treatment adjunct. No superiority was seen when saline was compared against a reflexology 'placebo'. Saline is not as effective as an intranasal steroid. Some evidence suggests that hypertonic solutions improve objective measures but the impact on symptoms is less clear.
  
  
  CONCLUSIONS
  Saline irrigations are well tolerated. Although minor side effects are common, the beneficial effect of saline appears to outweigh these drawbacks for the majority of patients. The use of topical saline could be included as a treatment adjunct for the symptoms of chronic rhinosinusitis.
authors.affiliation: Royal National Throat Nose and Ear Hospital, London/John Radcliffe Hospital, Oxford, Otolaryngology, Head & Neck Surgery/Cochrane ENT Disorders Group, Level LG1 West Wing, John Radcliffe Hospital, Oxford, UK, OX3 9DU. richard@richardharvey.com.au
authors.forename: R
authors.initials: R
authors.lastname: Harvey
authors.forename: S A
authors.initials: SA
authors.lastname: Hannan
authors.forename: L
authors.initials: L
authors.lastname: Badia
authors.forename: G
authors.initials: G
authors.lastname: Scadding
mesh_terms: D000328:Adult; D002648:Child; D002908:Chronic Disease; D003231:Conjunctivitis / Q000628:therapy; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic; D012220:Rhinitis / Q000628:therapy*; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D012852:Sinusitis / Q000628:therapy*; D012965:Sodium Chloride / Q000008:administration & dosage*; D007507:Therapeutic Irrigation
chemical_list: D007552:Isotonic Solutions; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride