A nest in renal fibrosis?
Sakairi and collaborators show that some tubular cells as well as some interstitial myofibroblasts express the intermediate filament protein nestin. These findings evoke questions about the origin and role of these nestin-positive cells in the development of tubulointerstitial fibrosis.
Bascands
J-L
JL
Institut National de la Santé et de la Recherche Medical, U858/12MR, Renal and Cardiac Remodeling, Toulouse, France. bascalou@toulouse.inserm.fr
Klein
J
J
Schanstra
J P
JP
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D018450:Disease Progression; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005355:Fibrosis; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism* / Q000473:pathology*; D009395:Nephritis, Interstitial / Q000209:etiology / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D064231:Nestin; D051381:Rats; D014517:Ureteral Obstruction / Q000150:complications
D015415:Biomarkers; D007381:Intermediate Filament Proteins; D009419:Nerve Tissue Proteins; C577486:Nes protein, rat; D064231:Nestin