Model of the reception of hedgehog morphogen concentration gradient: comparison with an extended range of experimental data.
The model for reception of the concentration gradient of the Hedgehog morphogen has been developed. The mechanism of co-operation of the proteins Patched, Smoothened, and Hedgehog is theoretically analyzed in terms of different versions of interactions within this group of proteins. The parametric stability of the modeled system is considered.
Gunbin
Konstantin V
KV
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Acad. Lavrent'ev Ave., Novosibirsk, 630090, Russia. genkvg@bionet.nsc.ru
Omelyanchuk
Leonid V
LV
Kogai
Vladislav V
VV
Fadeev
Stanislav I
SI
Kolchanov
Nikolay A
NA
D000818:Animals; D003198:Computer Simulation; D004268:DNA-Binding Proteins / Q000502:physiology*; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000502:physiology*; D053823:Hedgehog Proteins / Q000502:physiology*; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D014921:Wings, Animal / Q000502:physiology*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D014157:Transcription Factors; C092937:ci protein, Drosophila; C077245:hh protein, Drosophila