[Association between A1168C polymorphism in PAX4 gene and type 1 diabetes in Han Chinese].
OBJECTIVE
To explore whether A1168C polymorphisms in paired box gene 4 (PAX4) are associated with type 1 diabetes mellitus (T1DM) in Chinese Han population.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype A1168C polymorphisms in PAX4 gene. Totally 109 patients with T1DM and 251 control subjects were recruited. The frequency distributions of genotypes between two groups were analyzed by SPSS software.


RESULTS
The genotype distributions were in Hardy-Weinberg equilibrium both among T1DM cases and control subjects. No difference was observed in the genotype frequencies and allele frequencies between T1DM cases and control subjects (P > 0.05), nor was any disease association detected when patients were stratified according to age at diagnosis or sex (P > 0.05).


CONCLUSIONS
The A1168C single nucleotide polymorphism in PAX4 gene may not play an essential role in genetic T1DM susceptibility in Chinese Han population.
Zhang
Yun
Y
Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Xiao
Xin-hua
XH
Wang
Heng
H
Wang
Tong
T
Sun
Qi
Q
Yang
Guo-hua
GH
Fu
Yong
Y
Yuan
Tao
T
Zhang
Qian
Q
Liu
Qiu-ying
QY
D044466:Asian People; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D051761:Paired Box Transcription Factors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D018398:Homeodomain Proteins; C491709:PAX4 protein, human; D051761:Paired Box Transcription Factors