Nalorphine: increased sensitivity of monkeys formerly dependent on morphine.
Three rhesus monkeys Macaca mulatta, formerly dependent on morphine, had increased sensitivity to nalorphine's effect of suppressing operant responding for food, as compared with two monkeys with no history of morphine exposure. Within the dose range employed, nalorphine injections produced emesis, salivation, and hyperirritability in formerly morphine-dependent monkeys but not in controls.
Goldberg
S R
SR
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48104, USA.
Schuster
C R
CR
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D008253:Macaca mulatta; D009021:Morphine Dependence; D009269:Nalorphine / Q000008:administration & dosage / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D012054:Reinforcement, Psychology; D012472:Salivation / Q000187:drug effects; D014839:Vomiting / Q000139:chemically induced
D009292:Narcotic Antagonists; D009269:Nalorphine