The use of the antifungal agent miconazole as an inhibitor of Blastocystis hominis growth in Entamoeba histolytica/E. dispar cultures.
In regions with high prevalence, Blastocystis hominis is frequently found in association with Entamoeba histolytica/E. dispar in xenic cultures. Its exacerbated growth is often superimposed on the growth of amebas, thus impeding the continuation of the amebas in the culture, within a few generations. The present study reports on the excellent efficacy (100%) of the antifungal agent miconazole in eliminating B. hominis from cultures of E. histolytica/E. dispar, thereby maintaining the integrity of the trophozoites of the amebas. Nystatin presented low efficacy (33.3%).
Gonçalves
Alessandra Queiroga
AQ
Laboratório de Doenças Parasitárias, Departamento de Medicina Tropical, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil. queiroga@ioc.fiocruz.br
Viana
João da Costa
Jda C
Pires
Edna Maria
EM
Bóia
Márcio Neves
MN
Coura
José Rodrigues
JR
Silva
Edward Félix
EF
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D016845:Blastocystis hominis / Q000187:drug effects*; D003470:Culture Media; D004747:Entamoeba / Q000254:growth & development*; D004748:Entamoeba histolytica / Q000254:growth & development; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D003470:Culture Media; D008825:Miconazole