title: Myocardial functional and textural findings of the right and left ventricles and their association with cellular adhesion molecules in Behçet's disease.
abstract: OBJECTIVE
  This study was designed to assess whether ultrasonic reflectivity, evaluated by integrated backscatter analysis was associated with the severity of inflammation and diastolic dysfunction of the left (LV) and right ventricles (RV) in Behçet's disease (BD).
  
  
  METHODS
  The study consisted of 20 patients with BD and 18 healthy controls. The expression of CD11b and CD63 on the surface of granulocytes and monocytes were measured by flow cytometry. RV and LV diastolic functions were assessed by tricuspid and mitral annular tissue Doppler recordings, respectively. Backscatter cyclic variation (CV) and maximal intensity (IB) were measured in RV lateral wall, interventricular septum, and posterior LV wall from parasternal long-axis view, apex from apical four-chamber view, anterior, inferior, and lateral LV walls from parasternal short axis view.
  
  
  RESULTS
  The mean fluorescence intensity (MFI) of CD11b on granulocytes and CD63 on monocytes in BD patients was higher than those of controls. Patients with BD had smaller mitral and tricuspid annular early diastolic wave velocities and early/late diastolic wave velocity ratios (E/A) than controls. MFI of CD11b and CD63 was inversely correlated with tricuspid and mitral annular E/A in BD patients. CV of RV and global CV of LV were found to be diminished in BD patients than controls. CV of RV and global CV of LV showed a direct correlation with tricuspid and mitral annular E/A ratio, respectively.
  
  
  CONCLUSIONS
  There is an association between the levels of cellular adhesion molecules, deterioration of diastolic function, and altered myocardial ultrasonic reflectivity in BD.
authors.affiliation: Zonguldak Karaelmas University, Faculty of Medicine, Department of Cardiology, Zonguldak, Turkey. nesligul2004@hotmail.com
authors.forename: Nesligul
authors.initials: N
authors.lastname: Yildirim
authors.forename: Nilgun Solak
authors.initials: NS
authors.lastname: Tekin
authors.forename: Ishak Ozel
authors.initials: IO
authors.lastname: Tekin
authors.forename: Sait
authors.initials: S
authors.lastname: Dogan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aydin
authors.forename: Metin
authors.initials: M
authors.lastname: Gursurer
authors.forename: Aydin
authors.initials: A
authors.lastname: Dursun
authors.forename: Seher
authors.initials: S
authors.lastname: Bozboga
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000000981:diagnostic imaging* / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D013223:Statistics as Topic; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000378:metabolism*; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules