title: Peroxidation of subcellular organelles: formation of lipofuscinlike fluorescent pigments.
abstract: Lipid peroxidation of subcellular organelles gives fluorescent products which have fluorescence and excitation spectra similar to those of lipofuscin pigments. Fluorescence and excitation spectra and total fluorescence in the 460-nanometer region are useful for qualitative identification and quantitative measurement of the Schiff base product, a molecular damage site of lipid peroxidation which develops during some aging processes.
authors.affiliation: Department of Food Science and Technology, University of California, Davis 95616, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Chio
authors.forename: U
authors.initials: U
authors.lastname: Reiss
authors.forename: B
authors.initials: B
authors.lastname: Fletcher
authors.forename: A L
authors.initials: AL
authors.lastname: Tappel
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D015227:Lipid Peroxidation; D008062:Lipofuscin / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D011435:Propyl Gallate / Q000494:pharmacology; D051381:Rats; D012545:Schiff Bases / Q000032:analysis; D013050:Spectrometry, Fluorescence; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D000975:Antioxidants; D008062:Lipofuscin; D012545:Schiff Bases; D017392:Thiobarbituric Acid Reactive Substances; D011435:Propyl Gallate