[Comparative study on sequential colon dialysis, hemodialysis and peritoneal dialysis in patients with hyperuricemia].
OBJECTIVE
To evaluate the effects of sequential colon dialysis (SCD), hemodialysis (HD) and peritoneal dialysis (PD) on the serum level of uric acid (UA) in patients with hyperuricemia.


METHODS
A total of 293 patients with mild, moderate and severe degree of hyperuricemia were randomly assigned to three groups according to digital randomized method, and treated with SCD, HD and PD respectively. The serum level of UA was determined with unicase-peroxidase conjugate method, the blood levels of K+, Na+, Cl-, Ca2+ were determined by automatic biochemical analysor, and changes of body weight were measured before and after dialysis.


RESULTS
In the 293 cases, the three modes of dialysis showed no difference in lowering uric acid in patients of mild degree (P > 0.05). But the HD did show a better efficacy than that of the other two in severe degree patients (P<0.01), while in patients of moderate degree, significant difference (P<0.01) showed between HD and SCD, PD and SCD, but not between HD and PD (P > 0.05). No obvious effect of the various modes of dialysis on the level of K+, Na+, Cl-, Ca2+, body weight.


CONCLUSIONS
SCD can decrease the serum level of UA effectively and reduce the incidence of complication of hyperuricemia to some extent, as hemodialysis and peritoneal dialysis can.
Wang
Hai-tao
HT
Department of Nephrology, Guangzhou General Hospital of Guangzhou Command. wwanghaitao@hotmail.com
Chen
Ye
Y
Huang
Yuan-hang
YH
D000285:Administration, Rectal; D000293:Adolescent; D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood; D002712:Chlorides / Q000097:blood; D003106:Colon; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000379:methods*; D011188:Potassium / Q000097:blood; D006435:Renal Dialysis / Q000379:methods*; D012964:Sodium / Q000097:blood; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
D002712:Chlorides; D004365:Drugs, Chinese Herbal; D014527:Uric Acid; D012964:Sodium; D011188:Potassium; D002118:Calcium