Statistics of catalytic domain sequences in protein kinases vs non-kinases.
The catalytic regions of Protein Kinases are known to have similarity in primary chains. However, it is not known whether there is a signature profile specific to a particular catalytic region? Whether the signature profile, if any, is unique to a protein kinases family in a particular species or in a group of species? We have attempted analyzing some of these aspects by statistical data mining using an authentic and exhaustive database of Protein Kinases. The results reveal interesting features and provide some new directions to look at their applications.
Joshi
Rajani R
RR
Department of Mathematics, Indian Institute of Technology Bombay, Powai, Mumbai 40076, India. rrj@math.iitb.ac.in
Manda
Chaithanya
C
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000704:Analysis of Variance; D020134:Catalytic Domain; D019295:Computational Biology; D030562:Databases, Protein; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000737:chemistry* / Q000378:metabolism*; D021122:Protein Subunits / Q000737:chemistry* / Q000378:metabolism
D021122:Protein Subunits; D011494:Protein Kinases