title: Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA).
abstract: MRI-based cartilage morphometry was previously validated in the absence of gadopentate dimeglumine (Gd-DTPA). However, Gd-DTPA is required for compositional (proteoglycan) imaging using delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). Therefore, the effect of Gd-DTPA on cartilage morphometry was studied. A total of 165 female participants (67 with and 98 without osteoarthritis [OA]) were imaged at 3.0 Tesla before and 2 hr after intravenous Gd-DTPA injection. Flip angles in post-Gd-DTPA scans varied between 12 degrees and 35 degrees . Cartilage volume and thickness of post- vs. pre-Gd-DTPA scans showed intraclass correlation coefficients (ICCs) of 0.85 > or = r > or = 0.95, mean differences between -2.1% and +1.1%, and standard deviations (SDs) of differences between 4.7% and 9.2%. Mixed-effect models found no consistent impact of flip angle and OA status on post- vs. pre-Gd-DTPA differences. Accurate morphological measurements of cartilage can be obtained after Gd-DTPA injection, allowing compositional and morphological imaging to be combined into one session.
authors.affiliation: Institute of Anatomy and Musculoskeletal Research, Paracelsus Private University, Salzburg, Austria.
authors.forename: Felix
authors.initials: F
authors.lastname: Eckstein
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Buck
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Wyman
authors.forename: John J
authors.initials: JJ
authors.lastname: Kotyk
authors.forename: Marie-Pierre Hellio
authors.initials: MP
authors.lastname: Le Graverand
authors.forename: Ann E
authors.initials: AE
authors.lastname: Remmers
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Evelhoch
authors.forename: Martin
authors.initials: M
authors.lastname: Hudelmaier
authors.forename: H Cecil
authors.initials: HC
authors.lastname: Charles
mesh_terms: D000328:Adult; D000368:Aged; D002358:Cartilage, Articular / Q000473:pathology*; D003287:Contrast Media; D003430:Cross-Sectional Studies; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology*; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA