Immunohistochemical characterization of a sebaceous gland carcinoma in a gerbil (Meriones unguiculatus).
Sebaceous gland carcinoma is a common tumour in male gerbils but, to date, no information is available on its immunohistochemical properties. This report describes the histopathological and immunohistochemical features of such a tumour from a 4.5-year-old male gerbil. The tumour immunoreactivity profile was studied in respect of p53 protein, CEA, EMA, c-erbB-2, cytokeratin (CK) 14 and the CKs detected by AE1/AE3 antibodies (i.e. high molecular weight CKs 1, 2, 3, 4, 5, 6, 10, 14, 15 and 16, and low molecular weight CKs 7, 8 and 19). The differences observed in p53 and c-erbB-2 immunolabelling between carcinomatous and hyperplastic areas suggest that p53 mutations and amplification of c-erbB-2 may play a significant role in the oncogenesis of sebaceous gland carcinoma in the gerbil.
Gil da Costa
R M
RM
Instituto de Ciências Biomédicas de Abel Salazar, University of Porto, Portugal.
Rema
A
A
Payo-Puente
P
P
Gärtner
F
F
D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D005849:Gerbillinae; D053547:Keratin-14 / Q000378:metabolism; D008297:Male; D009154:Mutation / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D012626:Sebaceous Gland Neoplasms / Q000378:metabolism / Q000662:veterinary*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D053547:Keratin-14; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53