Spotlight on autoimmune lymphoproliferative syndrome.
This month's Spotlight on... reviews autoimmune lymphoproliferative syndrome (ALPS) and its treatment. ALPS is an inherited disease caused by defects in lymphocyte apoptosis that cause nonmalignant proliferation of lymphocytes with autoimmune manifestations. Although there is yet no specific treatment for ALPS, therapies selectively targeting lymphocyte apoptosis may open a new avenue in the treatment of this rare disorder.
Ferrer
Elisa
E
Prous Science, Barcelona, Spain. journals@prous.com
Moral
Maria Angels
MA
Bozzo
Jordi
J
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001327:Autoimmune Diseases / Q000473:pathology*; D053181:Caspase 8 / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008232:Lymphoproliferative Disorders / Q000473:pathology*; D008928:Mitochondria / Q000502:physiology
D053181:Caspase 8