title: Clinical and clinicopathologic variables in adult horses receiving blood transfusions: 31 cases (1999-2005).
abstract: OBJECTIVE
  To determine clinical and clinicopathologic abnormalities in horses administered a blood transfusion and evaluate effects of blood transfusion on these variables.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  31 adult horses that received > or = 1 blood transfusion. Procedures-Medical records of horses receiving a blood transfusion were reviewed to obtain clinical findings, laboratory test results before and after transfusion, adjunctive treatments, transfusion type and volume, response to transfusion, results of donor-recipient compatibility testing, adverse reactions, and outcome.
  
  
  RESULTS
  31 horses received 44 transfusions for hemorrhagic anemia (HG; n = 18 horses), hemolytic anemia (HL; 8), or anemia attributable to erythropoietic failure (EF; 5). Tachycardia and tachypnea were detected in 31 of 31 (100%) and 22 of 31 (71%) horses, respectively, before transfusion. The PCV and hemoglobin concentration were less than the reference range in 11 of 18 horses with HG, 8 of 8 horses with HL, and 5 of 5 horses with EF. Hyperlactatemia was detected in 16 of 17 recorded values before transfusion. Heart rate, respiratory rate, and PCV improved after transfusion, with differences among the types of anemia. Seventeen (54%) horses were discharged, 9 (29%) were euthanized, and 5 (16%) died of natural causes. Adverse reactions were evident during 7 of 44 (16%) transfusions, varying from urticarial reactions to anaphylactic shock.
  
  
  CONCLUSIONS
  Abnormalities in clinical and clinicopathologic variables differed depending on the type of anemia. Colic, cold extremities, signs of depression, lethargy, tachycardia, tachypnea, low PCV, low hemoglobin concentration, and hyperlactatemia were commonly detected before transfusion and resolved after transfusion.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Samuel D
authors.initials: SD
authors.lastname: Hurcombe
authors.forename: Margaret C
authors.initials: MC
authors.lastname: Mudge
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Hinchcliff
mesh_terms: D000740:Anemia / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D000818:Animals; D001788:Blood Grouping and Crossmatching / Q000662:veterinary; D001803:Blood Transfusion / Q000379:methods / Q000662:veterinary*; D005260:Female; D006470:Hemorrhage / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D006734:Horse Diseases / Q000401:mortality / Q000628:therapy*; D006736:Horses; D008297:Male; D012189:Retrospective Studies; D016019:Survival Analysis; D065227:Transfusion Reaction; D016896:Treatment Outcome