[Expresion of E-cadherin and catenins in urothelial carcinomas].
OBJECTIVE
We examined the presence of E-cadherin and alpha, beta and gamma catenins detected by immunohistochemistry and correlated with the classic variables: grade, stage and recurrence.


METHODS
The authors evaluated 37 transitional cell carcinomas. Biopsy specimens included no recurrent transitional cell carcinoma (n=19) and recurrent transitional cell carcinoma (n=18). Association of E-cadherin and alpha, beta and gamma catenins immunoreactivity with tumor grade, clinical stage and tumor recurrence was examined.


RESULTS
E-cadherin and gamma catenin expression were related to the clinical stage of the disease, alpha and beta catenins were not correlated with grade, stage and recurrence of disease.


CONCLUSIONS
Decreased E cadherin and gamma catenin expression were associated with advanced stage of the disease.
San Miguel Fraile
P
P
Servicio de Anatomía Patológica, Hospital POVISA, Vigo, Pontevedra. psanmiguel@povisa.es
Gómez de María
C
C
Donis Quintairos
L
L
Carrera Vazquez
A
A
Iglesias Martínez
P
P
Barreiro Barbosa
M J
MJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000096:biosynthesis*; D002295:Carcinoma, Transitional Cell / Q000378:metabolism*; D051177:Catenins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
D015820:Cadherins; D051177:Catenins