title: Apolipoprotein B is a better marker than non-HDL-cholesterol for the metabolic syndrome in Koreans.
abstract: Apolipoprotein B (apoB) concentration reflects the number of atherogenic particles and is closely associated with atherosclerosis. Non-HDL-cholesterol (non-HDL-C) has been considered a therapeutic target for patients with hypertriglyceridemia. We compared the predictive values of apoB and non-HDL-C for the metabolic syndrome (MetS) in 3335 Korean adults (mean age, 45.2 years) who participated consecutively in a health examination in a university hospital. Anthropometry, blood pressure, fasting glucose, lipid profiles and apoB were measured. MetS, as defined by a modification of the NCEP-ATP III criteria, was present in 22.1% of men and 16.1% of women. Among the components of the MetS, triglycerides showed the strongest correlation with apoB (r=0.393, P<0.001 in men, and r=0.326, P<0.001 in women) and non-HDL-C (r=0.376, P<0.001 in men, and r=0.349, P<0.001 in women). When apoB and non-HDL-C were mutually adjusted, the ORs for the MetS of non-HDL-C were not significant. As a function of the quartile of apoB levels, the ORs for the MetS were 2.04 (1.26-3.30), 3.54 (2.11-5.93), and 5.38 (3.16-9.17) in men (P for trend <0.001) and 3.75 (1.42-9.87), 5.55 (2.09-14.69), and 13.41 (5.02-35.79) in women (P for trend <0.001), respectively. These findings indicate that apoB is a better marker than non-HDL-C for identifying the MetS among Koreans.
authors.affiliation: Department of Family Medicine, Eulji General Hospital, Eulji University School of Medicine, South Korea.
authors.forename: Jee Hye
authors.initials: JH
authors.lastname: Han
authors.forename: Hye Soon
authors.initials: HS
authors.lastname: Park
authors.forename: Jeong A
authors.initials: JA
authors.lastname: Kim
authors.forename: Seon Mee
authors.initials: SM
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D001055:Apolipoproteins B / Q000097:blood*; D044466:Asian People / Q000706:statistics & numerical data; D015415:Biomarkers / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis* / Q000208:ethnology; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D001055:Apolipoproteins B; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL