[Expression of hypoxia inducible factor-1alpha and relationship thereof to apoptosis related protein in non-small cell lung cancer].
OBJECTIVE
To investigate the expression of hypoxia inducible factor-1alpha (HIF-1alpha) and relationship thereof to survivin and Bax, apoptosis related proteins, in non-small cell lung cancer (NSCLC).


METHODS
Immunohistochemistry was used in 52 specimens of NSCLC to detect the expression of HIF-1alpha, survivin and Bax.


RESULTS
The positive rates of HIF-1alpha, survivin and Bax were 38.5% (20/52), 48.1% (25/52), and 42.3% (22/52) respectively. The higher the pathological stage of tumor, the higher expression rate of HIF-1alpha (chi2=8.271, P<0.05). The positive rate of HIF-1alpha expression of the patients with lymph node metastasis was higher than that of the patients without lymph node metastasis (chi2=6.370, P<0.05). However, HIF-1alpha expression had no relationship to the pathological type (chi2=0.561, P>0.05) and differentiation degree (chi2=0.326, P>0.05). Correlation analysis showed that the expression of HIF-1alpha was positively correlated with the surviving expression (gamma=0.496, P<0.05) and Bax expression (gamma=0.681, P<0.05).


CONCLUSIONS
The expression of HIF-1alpha is related to the infiltration, metastasis, and apoptosis of NSCLC.
Chen
Yong-feng
YF
Department of Respiratory, Xinan Hospital, Third Military Medical University, Chongqing 400038, China.
Yang
He-ping
HP
Hu
Jian-lin
JL
Zhou
Xiang-dong
XD
Xiong
Wei
W
Dai
Xiao-tian
XT
Li
Xue-jun
XJ
D000328:Adult; D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis*; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009367:Neoplasm Staging; D000077022:Survivin; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis
D051017:Apoptosis Regulatory Proteins; C107489:BIRC5 protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin; D051028:bcl-2-Associated X Protein