title: CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair.
abstract: Studies of stromal cell populations in lymphoid tissue (LT) have been hampered by a lack of selective markers. Here, we show that CD248 (Endosialin/TEM1) is a stromal marker that is differentially expressed on fibroblasts and pericytes in the thymus, lymph node and spleen. Expression is high during LT development but largely disappears in the adult. CD248 is re-expressed in a Salmonella-induced model of splenic enlargement; peak expression corresponding to the peak of splenic enlargement. These results suggest that CD248 expression helps define a subset of LT stromal cells which play a role in remodelling during tissue development, infection and repair.
authors.affiliation: Division of Immunity and Infection, Institute for Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
authors.forename: Siân
authors.initials: S
authors.lastname: Lax
authors.forename: Tie Zheng
authors.initials: TZ
authors.lastname: Hou
authors.forename: Eric
authors.initials: E
authors.lastname: Jenkinson
authors.forename: Mike
authors.initials: M
authors.lastname: Salmon
authors.forename: John R
authors.initials: JR
authors.lastname: MacFadyen
authors.forename: Clare M
authors.initials: CM
authors.lastname: Isacke
authors.forename: Graham
authors.initials: G
authors.lastname: Anderson
authors.forename: Adam F
authors.initials: AF
authors.lastname: Cunningham
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Buckley
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D001402:B-Lymphocytes / Q000378:metabolism; D015415:Biomarkers; D002452:Cell Count; D018507:Gene Expression Regulation, Developmental; D008221:Lymphoid Tissue / Q000196:embryology* / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009363:Neoplasm Proteins / Q000378:metabolism*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D012480:Salmonella Infections / Q000378:metabolism / Q000473:pathology; D013154:Spleen / Q000196:embryology* / Q000378:metabolism*; D017154:Stromal Cells / Q000378:metabolism*; D013997:Time Factors
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D009363:Neoplasm Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; C509258:tumor endothelial marker 1, mouse