Dissociative electron attachment to di-tert-butylperoxide, artemisinin, and beta-artemether.
The gas-phase dissociative electron attachment spectra of di-tert-butylperoxide (DBP) and the antimalarial polycyclic peroxides artemisinin and beta-artemether are presented for the first time. The total anion currents measured at the walls of the collision chamber and the mass selected anion currents are reported in the 0-6 eV energy range. Electron attachment to DBP produces an intense current, peaking at 1.3 eV, due to the C4H9O- negative fragment, in line with the strongly O-O antibonding character of the singly occupied orbital of the parent molecular anion and the small (if any) thermodynamic energy threshold predicted by B3LYP calculations for the formation of this anion fragment. A five times less intense signal, with m/e = 57 and a maximum at 0.7 eV, is also observed. The calculations exclude that this signal can be associated with the C4H9- negative fragment, whereas they support its assignment to the C3H5O- species, generated by simultaneous dissociation and loss of a methane molecule from the parent molecular anion. In DBP, artemisinin, and beta-artemether, currents corresponding to the parent molecular anion are not detected, indicating that its survival time is shorter than the time required (about 10-6 s) to pass through the mass filter. In the latter two compounds, where simple O-O bond breaking does not generate separate fragments, the anion currents are much weaker than in DBP and the maximum total anion current peaks at zero energy.
Modelli
Alberto
A
Dipartimento di Chimica "G. Ciamician", Università di Bologna, I-40126 Bologna, Italy. alberto.modelli@unibo.it
Galasso
Vinicio
V
D000077549:Artemether; D037621:Artemisinins / Q000737:chemistry*; D004563:Electrochemistry; D004583:Electrons; D010545:Peroxides / Q000737:chemistry*
D037621:Artemisinins; D010545:Peroxides; C111570:di-tert-butyl peroxide; C031327:artemisinin; D000077549:Artemether