title: Anterior anal fissures are associated with occult sphincter injury and abnormal sphincter function.
abstract: OBJECTIVE
  The pathogenesis of chronic anal fissure (CAF) remains incompletely understood but most are associated with a high resting anal pressure and reduced perfusion at the fissure site. To date, no major distinction has been made between anterior and posterior anal fissures and their aetiology and treatment. We compared anterior and posterior fissures in patients who have failed to respond to medical treatment with respect to their underlying aetiology, anal canal pressures and sphincter muscle integrity.
  
  
  METHODS
  Seventy consecutive patients (54 female:16 male) with a symptomatic CAF and 39 normal controls (19 female:20 male) without evidence of significant ano-rectal pathology were prospectively assessed by manometry and anal endosonography.
  
  
  RESULTS
  Anterior anal fissures were identified in a younger age group [33 years (IQR 26-37) vs 41 years (IQR 36-52)] and predominantly in women. Anterior fissure patients were significantly more likely to have underlying external anal sphincter defects compared with posterior fissures [OR 10.9 (95% CI 3.4-35.4)]. Maximum resting pressure was not significantly elevated for anterior fissures compared with controls (P = 0.316) but was significantly elevated in posterior fissures (P = 0.005). The maximum squeeze pressure was significantly lower in the anterior fissure group [167 cmH2O (IQR 126-196) vs 205 cmH2O (IQR 174-262), P = 0.004]. A history of obstetric trauma was significantly associated with anterior fissure location [OR 13.9 (95% CI 3.4-55.7)].
  
  
  CONCLUSIONS
  Anterior anal fissures are associated with occult external anal sphincter injury and impaired external anal sphincter function compared with posterior fissures. These findings have implications for treatment, especially if a definitive procedure, such as lateral internal sphincterotomy, is considered.
authors.affiliation: Department of Surgical Gastroenterology, Gartnavel General Hospital, Glasgow, UK.
authors.forename: J T
authors.initials: JT
authors.lastname: Jenkins
authors.forename: A
authors.initials: A
authors.lastname: Urie
authors.forename: R G
authors.initials: RG
authors.lastname: Molloy
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000293:injuries* / Q000503:physiopathology*; D001004:Anus Diseases / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D016022:Case-Control Studies; D002908:Chronic Disease; D019160:Endosonography; D005260:Female; D005401:Fissure in Ano / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric