Enhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART.
In patients co-infected with HIV-1 and GB virus C (GBV-C), the disappearance of GBV-C RNA has been associated with accelerated disease progression. We studied longitudinal GBV-C viral titres in 28 HIV-1/GVB-C co-infected individuals receiving HAART. During HAART, median GBV-C RNA titres increased from 95 to 6000 copies/ml (P < 0.001). In patients interrupting HAART, GBV-C-RNA titres decreased as HIV replication resumed. These findings further support the theory that GBV-C replication could depend on the dynamics of HIV progression.
Björkman
Per
P
Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden.
Flamholc
Leo
L
Molnegren
Vilma
V
Marshall
Aline
A
Güner
Nuray
N
Widell
Anders
A
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D018178:Flaviviridae Infections / Q000150:complications* / Q000821:virology; D005500:Follow-Up Studies; D029407:GB virus C / Q000502:physiology*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D015497:HIV-1; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D014779:Virus Replication
D019380:Anti-HIV Agents