[Pinealectomy decreases chronotropic activity of anxiolytics and increases effect of psychostimulant drugs].
In pinealectomized rats decrease of anxiolytics possibility to stabilize circadian locomotion rhythm and increase psychostimulant chronotropic effect were observed after compare with shame operated controls. As proposed pineal hormone melatonin may to participate in chronotropic and specific activity of some psychotropic drugs.
Arushanian
E B
EB
Popov
A V
AV
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects*; D008297:Male; D010870:Pineal Gland / Q000502:physiology* / Q000601:surgery; D051381:Rats
D014151:Anti-Anxiety Agents; D000697:Central Nervous System Stimulants; D002110:Caffeine; D000661:Amphetamine