Increased acylated plasma ghrelin, but improved lipid profiles 24-h after consumption of carob pulp preparation rich in dietary fibre and polyphenols.
We have recently shown that a polyphenol-rich insoluble dietary fibre preparation from carob pulp (Ceratonia siliqua L; carob fibre) decreased postprandial acylated ghrelin, TAG and NEFA during an acute liquid meal challenge test. However, delayed effects of carob fibre consumption are unknown. Therefore, a randomized controlled crossover study in nineteen healthy volunteers consuming foods with or without 50 g carob fibre was conducted. On the subsequent day (day 2), glucose, TAG, total and acylated ghrelin as well as insulin, NEFA and leptin were assessed at baseline and at timed intervals for 300 min after ingestion of standardized bread. Consumption of carob fibre-enriched foods did not affect fasting concentrations of glucose, TAG, total ghrelin, NEFA, insulin and leptin. Fasting acylated ghrelin was increased on the day subsequent to carob fibre consumption compared with control (P = 0.046). After consumption of the standard bread on day 2, glucose response (P = 0.029) was increased, and TAG (P = 0.033) and NEFA (P < 0.001) responses were decreased compared with control. Postprandial responses of total and acylated ghrelin, insulin and leptin on day 2 were unaffected by carob fibre consumption the previous day. In conclusion, an increase in total and acylated plasma ghrelin accompanied by enhanced lipid metabolism after carob fibre consumption suggests higher lipid utilization and suppressed lipolysis on the day subsequent to carob fibre consumption. However, elevated glucose levels after carob fibre consumption need to be addressed in future studies.
Gruendel
Sindy
S
Dietary Fibre and the Metabolic Syndrome Research Group, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Garcia
Ada L
AL
Otto
Baerbel
B
Wagner
Karen
K
Bidlingmaier
Martin
M
Burget
Lukas
L
Weickert
Martin O
MO
Dongowski
Gerhard
G
Speth
Maria
M
Katz
Norbert
N
Koebnick
Corinna
C
D000215:Acylation; D000328:Adult; D000428:Alcohol Drinking; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D003106:Colon / Q000378:metabolism; D018592:Cross-Over Studies; D004043:Dietary Fiber / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage*; D005685:Galactans; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008351:Mannans; D008875:Middle Aged; D010636:Phenols / Q000008:administration & dosage*; D053149:Plant Gums; D059808:Polyphenols; D014280:Triglycerides / Q000032:analysis
D001786:Blood Glucose; D004043:Dietary Fiber; D005230:Fatty Acids, Nonesterified; D005419:Flavonoids; D005685:Galactans; D054439:Ghrelin; D007328:Insulin; D008055:Lipids; D008351:Mannans; D010636:Phenols; D053149:Plant Gums; D059808:Polyphenols; D014280:Triglycerides; C017471:locust bean gum