title: Differences in current clinical features of diploid and triploid hydatidiform mole.
abstract: OBJECTIVE
  To describe and compare the current clinical features of diploid and triploid molar pregnancy and to evaluate whether the presenting clinical features can predict the ploidy of a molar pregnancy.
  
  
  METHODS
  A retrospective study of the clinical features and ploidy of hydatidiform moles.
  
  
  METHODS
  The Departments of Clinical Genetics and Pathology, Aarhus University Hospital and 13 gynaecological wards, Jutland, Denmark.
  
  
  METHODS
  A total of 259 women with molar pregnancy diagnosed between April 1986 and June 2003.
  
  
  METHODS
  A review of medical records of consecutively collected, clinically suspected cases of molar pregnancy was performed. The molar ploidy was determined by karyotyping, flow cytometry, and/or analysis of polymorphic DNA markers.
  
  
  METHODS
  Maternal characteristics, presenting symptoms, initial human chorionic gonadotrophin (hCG), and molar ploidy.
  
  
  RESULTS
  In a multiple logistic regression model, initial hCG of > or = 100,000 iu/l (P < 0.001), first-trimester gestational age (P < 0.001), vaginal bleeding (P < 0.001), and maternal age of > or = 40 years (P = 0.03) were independent predictors of diploid mole. Women with excessive uterine size more frequently had a diploid than a triploid mole (P < 0.001). Fifty-four percent of the women with triploid mole and 27% of the women with diploid mole were diagnosed before onset of symptoms (P < 0.001).
  
  
  CONCLUSIONS
  The current clinical features of diploid mole are different from those of triploid mole. The presenting clinical profile of a molar pregnancy may be used as an early predictor of the molar ploidy and thus of the prognosis.
authors.affiliation: Department of Clinical Genetics, University Hospital of Aarhus, Aarhus, Denmark. in@dadlnet.dk
authors.forename: I
authors.initials: I
authors.lastname: Niemann
authors.forename: L K
authors.initials: LK
authors.lastname: Petersen
authors.forename: E S
authors.initials: ES
authors.lastname: Hansen
authors.forename: L
authors.initials: L
authors.lastname: Sunde
mesh_terms: D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin / Q000378:metabolism; D005260:Female; D020073:Gravidity; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000235:genetics* / Q000473:pathology; D016015:Logistic Models; D008875:Middle Aged; D011003:Ploidies; D011247:Pregnancy; D012189:Retrospective Studies; D014592:Uterine Hemorrhage / Q000209:etiology; D014594:Uterine Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology
chemical_list: D006063:Chorionic Gonadotropin