Non-compliance in pyridoxine-dependent seizures and a way out.
Pyridoxine dependency is a rare autosomal-recessive disorder causing intractable seizures in neonates and infants. Life-long therapy with pyridoxine is required for prevention of seizure recurrence and for an optimum intellectual outcome. With the availability of newer biochemical confirmatory tests, the conventional pyridoxine-withdrawal test is being used less frequently for diagnosis. This report describes an infant whose parents were non-compliant with pyridoxine therapy and proposes that pyridoxine-withdrawal test may be useful in demonstrating to parents the need for life-long pyridoxine therapy, thereby reducing non-compliance.
Kumar
Praveen
P
Department of Pediatrics, Dr Ram Manohar Lohia Hospital, New Delhi, India.
Gupta
Vijay K
VK
Mishra
Devendra
D
D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D010349:Patient Compliance; D011736:Pyridoxine / Q000172:deficiency / Q000627:therapeutic use*; D012640:Seizures / Q000151:congenital / Q000188:drug therapy*; D016896:Treatment Outcome
D011736:Pyridoxine