Synthesis, X-ray structure, and pharmacological activity of some 6,6-disubstituted chromeno[4,3-b]- and chromeno- [3,4-c]-quinolines.
Some chromeno[4,3-b]quinolines 4a-i were obtained from beta-chloro carboxyaldehydes 3a-c with different aniline derivatives namely, aniline, 4-fluoroaniline, and 2-aminophenol. Surprisingly, 3a-c reacted with 2-aminothiophenol and afforded the chromeno[3,4-c]quinoline derivatives 5a-c. Single-crystal X-ray diffraction studies of 4e and 5b provided good support for the established structure. Compounds 4b and 5b showed significant anti-inflammatory and ulcerogenic score activities compared to that of indomethacin.
Hegab
Mohamed I
MI
Department of Chemistry, Cairo University, Cairo, Egypt. mihegab65@yahoo.com
Abdel-Fattah
Abdel-Samee M
AS
Yousef
Nabil M
NM
Nour
Hany F
HF
Mostafa
A M
AM
Ellithey
Mohey
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D005260:Female; D008297:Male; D051379:Mice; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D011804:Quinolines