The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides.
Amides can be hydrogenated to amines using a catalyst prepared in situ from [Ru(acac)(3)] and 1,1,1-tris(diphenylphosphinomethyl)ethane; water is required to stabilize the catalyst and primary amines can only be formed (selectivity up to 85%) if ammonia is also present.
Núñez Magro
Angel A
AA
EaStCHEM, School of Chemistry, University of St. Andrews, St. Andrews, Fife, Scotland, UK KY16 9ST.
Eastham
Graham R
GR
Cole-Hamilton
David J
DJ