Cu-catalyzed tandem C-N bond formation for the synthesis of pyrroles and heteroarylpyrroles.
A highly efficient Cu-catalyzed tandem C-N bond-forming reaction of 1,4-dihalo-1,3-dienes has been developed. The transformation allows the synthesis of pyrroles and heteroarylpyrroles with a wide variety of functional groups and substitution patterns from readily available precursors.
Martín
Rubén
R
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Larsen
Catharine H
CH
Cuenca
Ana
A
Buchwald
Stephen L
SL
D000475:Alkenes / Q000138:chemical synthesis; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis; D011758:Pyrroles / Q000138:chemical synthesis*
D000475:Alkenes; D006571:Heterocyclic Compounds; D006846:Hydrocarbons, Halogenated; D011758:Pyrroles; D003300:Copper