Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.
Stocks
Paul A
PA
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
Bray
Patrick G
PG
Barton
Victoria E
VE
Al-Helal
Mohammed
M
Jones
Michael
M
Araujo
Nuna C
NC
Gibbons
Peter
P
Ward
Stephen A
SA
Hughes
Ruth H
RH
Biagini
Giancarlo A
GA
Davies
Jill
J
Amewu
Richard
R
Mercer
Amy E
AE
Ellis
Gemma
G
O'Neill
Paul M
PM
D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D006418:Heme / Q000737:chemistry*; D007502:Iron Chelating Agents / Q000737:chemistry*; D010545:Peroxides / Q000737:chemistry / Q000494:pharmacology*
D000962:Antimalarials; D007502:Iron Chelating Agents; D010545:Peroxides; D006418:Heme