Luteal phase oestradiol administration in ovarian stimulation cycles with GnRH antagonist is comparable to the GnRH agonist (long) protocol.
OBJECTIVE
The purpose of the study was to compare the effectiveness of GnRH antagonist with luteal phase estradiol administration to GnRH agonist cycles, long protocol.


METHODS
55 IVF-ICSI patients received oestradiol in the luteal phase of the cycle, before a cycle with GnRH antagonist. Fifty-five patients submitted to IVF-ICSI with the use of agonist were allocated, age matched, as a control group (historical control). The primary outcome was the number of retrieved oocytes.


RESULTS
Patients were similar in terms of clinical characteristics. No differences were found in the number of oocytes retrieved (study group, 8.1 +/- 4.7; control group, 7.4 +/- 4.5) or in oocyte quality.


CONCLUSIONS
We clearly demonstrated that the effectiveness of GnRH antagonist when combined with luteal phase estradiol is comparable to GnRH agonist cycles.
Cunha Filho
J S
JS
Ob/Gyn depto., Hospital de Clínicas de Porto Alegre, Programa de Pós-graduação em Ciências Médicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcellos, 2350, Porto Alegre, RS, CEP 90035-003, Brazil. sabino@via-rs.net
Terres
L F
LF
Holanda
F
F
Freitas
F
F
Glitz
C
C
Genro
V K
VK
Arbo
E
E
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D010064:Embryo Implantation / Q000187:drug effects / Q000502:physiology*; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000037:antagonists & inhibitors*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage*; D008183:Luteal Phase / Q000187:drug effects* / Q000378:metabolism; D009865:Oocytes / Q000187:drug effects*; D010062:Ovulation Induction; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic
D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D016729:Leuprolide