A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
Type 1 diabetes (T1D) in children results from autoimmune destruction of pancreatic beta cells, leading to insufficient production of insulin. A number of genetic determinants of T1D have already been established through candidate gene studies, primarily within the major histocompatibility complex but also within other loci. To identify new genetic factors that increase the risk of T1D, we performed a genome-wide association study in a large paediatric cohort of European descent. In addition to confirming previously identified loci, we found that T1D was significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13. This region contains KIAA0350, the gene product of which is predicted to be a sugar-binding, C-type lectin. Three common non-coding variants of the gene (rs2903692, rs725613 and rs17673553) in strong linkage disequilibrium reached genome-wide significance for association with T1D. A subsequent transmission disequilibrium test replication study in an independent cohort confirmed the association. These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits.
Hakonarson
Hakon
H
Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. hakonarson@chop.edu
Grant
Struan F A
SF
Bradfield
Jonathan P
JP
Marchand
Luc
L
Kim
Cecilia E
CE
Glessner
Joseph T
JT
Grabs
Rosemarie
R
Casalunovo
Tracy
T
Taback
Shayne P
SP
Frackelton
Edward C
EC
Lawson
Margaret L
ML
Robinson
Luke J
LJ
Skraban
Robert
R
Lu
Yang
Y
Chiavacci
Rosetta M
RM
Stanley
Charles A
CA
Kirsch
Susan E
SE
Rappaport
Eric F
EF
Orange
Jordan S
JS
Monos
Dimitri S
DS
Devoto
Marcella
M
Qu
Hui-Qi
HQ
Polychronakos
Constantin
C
D016022:Case-Control Studies; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D037181:Lectins, C-Type; D015810:Linkage Disequilibrium / Q000235:genetics; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D009679:Nuclear Family; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
C522505:CLEC16A protein, human; D005819:Genetic Markers; D037181:Lectins, C-Type; D009004:Monosaccharide Transport Proteins