[Post-exercise microalbuminuria in newly diagnosed type 1 diabetic children - preliminary report].
OBJECTIVE
of this study was the evaluation of some factors having an influence on post-exercise albuminuria level in children with newly diagnosed type 1 diabetes as a prognostic factor of developing nephropathy.


METHODS
24 newly diagnosed type 1 diabetic children, aged 5.5-16.9 years, mean 10.2+/-3.2, were examined. In order to provoke albuminuria the patients underwent standardized exercise test using treadmill ramp according to the Bruce protocol. Pre- and post-exercise albuminuria and C-peptide levels by radioimmunoassay were evaluated. In urine of patients the albumin / creatinine ratio (ACR) was determined.


RESULTS
the tendency towards an increase in ACR ratio in children after exercise (10.5 mg/g (4-27.5) in comparison to the value in pre-exercise urine (7 mg/g (2.5-13), p=0.17) was observed. In 67% of patients (16/24) the ACR ratio was higher in post-exercise urine. In 25% of children (6/24) the ACR ratio was above 30 mg/g which was considered as post-exercise microalbuminuria. Next, parameters of metabolic control of type 1 diabetes were compared between patients with and without post-exercise microalbuminuria. No differences in the serum glucose, HbA1c, BMI, triglycerides, total cholesterol, insulin dose, frequency of ketoacidosis and C-peptide level between these groups of children were noted.


CONCLUSIONS
we concluded that the post-exercise microalbuminuria as a marker of diabetic nephropathy risk may be observed in some patients already at the clinical onset of type 1 diabetes but further evaluation is needed to verify this hypothesis.
Zmysłowska
Agnieszka
A
Klinika Chorób Dzieci I Katedry Pediatrii UM, ul. Sporna 36/50, 91-738 Łodz, Poland. agazmysl@poczta.onet.pl
Młynarski
Wojciech
W
Wegner
Olga
O
Misiak
Grzegorz
G
Szadkowska
Agnieszka
A
Bodalski
Jerzy
J
D000293:Adolescent; D000419:Albuminuria / Q000175:diagnosis / Q000209:etiology*; D015415:Biomarkers / Q000652:urine; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000652:urine*; D003928:Diabetic Nephropathies / Q000175:diagnosis* / Q000209:etiology / Q000652:urine; D005080:Exercise Test; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D010455:Peptides / Q000097:blood; D010865:Pilot Projects
D015415:Biomarkers; D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin; D010455:Peptides; C050632:polypeptide C