[Protective effect of hypothermia on brain neurons of rats exposed to ionizing radiation].
The conditions of the protein-synthesizing system in neurons of the hippocampus (areas CA1 and C A3) and of the cortex (sensomotor region) in rats subjected to y-irradiation at a dose of 8 Gy under hypothermia (16 - 18 degrees C) and hypoxia-hypercapnia were investigated by fluorescent and electron microscopy. Under hypothermia, the protein-synthesizing system was shown to be damaged to a lesser degree and to be restored faster in comparison with similar neurons in rats irradiated at room temperature. In rats irradiated under hypothermia, the rRNA biogenesis and the protein-synthesizing activity of polyribosomes were restored in two days. The protective influence of hypothermia did not spread to changes in membrane structures (endoplasmic reticulum and Golgy apparatus); i.e., a partial loss of integrity and possible transformation of their structure caused by the irradiation and the restoration of these structures occurred at a lower rate.
Gordon
R Ia
RIa
Ignat'ev
D A
DA
Mel'nikova
E B
EB
Rogachevskiĭ
V V
VV
Kraev
I V
IV
Hutsian
S S
SS
D000818:Animals; D001921:Brain / Q000528:radiation effects* / Q000648:ultrastructure; D007036:Hypothermia, Induced; D008297:Male; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000378:metabolism / Q000528:radiation effects* / Q000648:ultrastructure; D014176:Protein Biosynthesis / Q000528:radiation effects; D011832:Radiation Injuries / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar