[Extracellular and cell-matrix interaction in pathology].
A lot of physiological processes including cell proliferation, cell migration, and differentiation are regulated by intercellular and cell-matrix interaction. The misbalance of intercellular and stroma-epithelial interaction is one of main factor of initiation of different pathological processes. Nonhealing wounds (chronic inflammation) and adenocarcinomas, despite the different external features, have many general inner features: cell proliferation, survival, cell migration, differentiation induced by cocktail of different growth factors and cytokines which promote inflammation and angiogenesis. Various stroma components including extracellular matrix are active participants of wound healing and cancer growth. The changes of pl-integrins distribution and cytokine expression, TGFbeta in particular, influence the development of pathological processes. It is possible to consider these factors as potential pharmacological targets.
Pal'tsev
M A
MA
Ivanov
A A
AA
D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology*; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis; D014945:Wound Healing; D014947:Wounds and Injuries / Q000378:metabolism / Q000473:pathology*
D016212:Transforming Growth Factor beta