Sarcoidal granulomatous tenosynovitis of the hands occurring in an organ transplant patient.
Six years after kidney-pancreas transplant, a 47-year-old white man developed multiple subcutaneous and tenosynovial nodules of hands and wrists, limiting mobility. Biopsy of multiple nodules showed fibrosing, sarcoidal granulomas, some of which contained pigmented material. Microbiology, immunohistochemistry, scanning electron microscopy with backscattered electron imaging and energy dispersive X-ray analysis and polymerase chain reaction assays failed to show any infectious agents or foreign material. There was no historical, clinical or laboratory evidence of systemic sarcoidosis. It is not known whether the donor had sarcoidosis. Despite empiric antimycobacterial therapy and ongoing immunosuppressive therapy (corticosteroids, mycophenolate, cyclosporine), the man has progressively developed more nodules, limiting hand function. Sarcoidosis occurring in non-donor tissue post-transplantation is an exceedingly rare complication of transplantation. We discuss this case and review the literature on sarcoidal tenosynovitis and sarcoidosis occurring post-transplantation.
Carlson
J Andrew
JA
Divisions of Dermatopathology and Dermatology, Department of Pathology and Laboratory Medicine, Albany Medical College MC-81, Albany, NY 12208, USA. carlsoa@mail.amc.edu
Wei-Lee
Hung
H
Kutzner
Heinz
H
Jones
David M
DM
Tobin
Ellis
E
D006099:Granuloma / Q000209:etiology / Q000473:pathology; D006225:Hand; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D011183:Postoperative Complications; D012507:Sarcoidosis / Q000150:complications / Q000473:pathology*; D013717:Tenosynovitis / Q000209:etiology / Q000473:pathology*