title: Ribavirin: analytical determinations since the origin until today.
abstract: Ribavirin (RV) (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), is a synthetic purine nucleoside analog with a broad spectrum of antiviral activity. To better understand the mechanism of action of RV, as well as its pharmacokinetic characteristics, an assay that can allow specific, sensitive, and accurate measurement of RV in biologic samples is critical. In this way, diverse analytical methods have been established. In this work, we have recompiled these methods with the aim to present the different options for the RV determination.
authors.affiliation: Department of Pharmacy, General Hospital, University Hospital Virgen del Rocío, Manuel Siurot s/n, 41013 Sevilla, Spain.
authors.forename: M Espinosa
authors.initials: ME
authors.lastname: Bosch
authors.forename: A J Ruiz
authors.initials: AJ
authors.lastname: Sánchez
authors.forename: F Sánchez
authors.initials: FS
authors.lastname: Rojas
authors.forename: C Bosch
authors.initials: CB
authors.lastname: Ojeda
mesh_terms: D000998:Antiviral Agents / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D005470:Fluorometry / Q000379:methods; D008163:Luminescent Measurements; D015394:Molecular Structure; D011684:Purine Nucleosides / Q000032:analysis* / Q000737:chemistry; D011869:Radioligand Assay; D012254:Ribavirin / Q000032:analysis* / Q000737:chemistry; D012263:Ribonucleosides / Q000032:analysis* / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods
chemical_list: D000998:Antiviral Agents; D011684:Purine Nucleosides; D012263:Ribonucleosides; D012254:Ribavirin