title: [The impact of antepartum injection of hepatitis B immunoglobulin on maternal serum HBV DNA and anti-HBs in the newborns].
abstract: OBJECTIVE
  To investigate the effect of antepartum injection of hepatitis B immunoglobulin (HBIG) on the maternal serum HBV DNA and the delivery of anti-HBs to the newborns.
  
  
  METHODS
  Before and after injection of three doses of HBIG, Serum HBV DNA levels were detected by fluorescence quantitative PCR in 10 non-pregnant and 23 pregnant women of chronic hepatitis B virus (HBV) carrier state. In addition, serum anti-HBs were tested by an enzyme-linked immunoassay in 28 infants born to chronic HBV carrier mothers who received three doses of HBIG during the last trimester pregnancy.
  
  
  RESULTS
  Before and after injection of three doses of HBIG the serum HBV DNA levels in 10 non-pregnant and 23 pregnant women of HBV carrier state were not statistically different [(8.18 +/- 0.50) lg copies/ml vs (7.64 +/- 0.41) lg copies/ml and (6.83 +/- 1.51) lg copies/ml vs (6.83 +/- 1.29) lg copies/ml, respectively]. None of the 28 newborns were positive for anti-HBs.
  
  
  CONCLUSIONS
  The administration of three doses of HBIG during the last trimester pregnancy can not reduce the maternal serum HBV DNA levels and the injected HBIG can not be transferred to their newborns. Therefore, there is no sound evidence to support the use of this approach to block mother-to-infant HBV transmission.
authors.affiliation: Qinhuangdao Third Hospital, Qinhuangdao 066001, China. hanzh0338@sina.com
authors.forename: Zhong-Hou
authors.initials: ZH
authors.lastname: Han
authors.forename: Lian-Hua
authors.initials: LH
authors.lastname: Zhong
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Qing-Li
authors.initials: QL
authors.lastname: Zhao
authors.forename: Yu-Ge
authors.initials: YG
authors.lastname: Sun
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Li
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Cao
authors.forename: Xiang-Chun
authors.initials: XC
authors.lastname: Hao
authors.forename: Hui
authors.initials: H
authors.lastname: Zhuang
mesh_terms: D004279:DNA, Viral / Q000097:blood*; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use*; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third
chemical_list: D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D007136:Immunoglobulins; C045213:hepatitis B hyperimmune globulin