title: Frontal dysfunction during a cognitive task in drug-naive patients with panic disorder as investigated by multi-channel near-infrared spectroscopy imaging.
abstract: The present study investigated oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hb]) hemoglobin concentration changes during the performance of a word fluency task in the frontal region of five drug-naive patients with panic disorder with or without agoraphobia and in 33 age-, sex-, and task performance-matched healthy volunteers by using multi-channel near-infrared spectroscopy (NIRS). The left inferior frontal [oxy-Hb] changes during performance of the task in patients with panic disorder were significantly smaller than those of healthy controls. This pilot study suggests the possibility that the left frontal lobe, required for cognitive function, is impaired in patients with panic disorder.
authors.affiliation: Department of Psychiatry, Division of Neuroscience, Mie University, Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, Japan. ynishimu@clin.medic.mie-u.ac.jp
authors.forename: Yukika
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tanii
authors.forename: Masato
authors.initials: M
authors.lastname: Fukuda
authors.forename: Naomi
authors.initials: N
authors.lastname: Kajiki
authors.forename: Ken
authors.initials: K
authors.lastname: Inoue
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Kaiya
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nishida
authors.forename: Motohiro
authors.initials: M
authors.lastname: Okada
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okazaki
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities* / Q000098:blood supply / Q000503:physiopathology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D016584:Panic Disorder / Q000473:pathology / Q000503:physiopathology*; D019265:Spectroscopy, Near-Infrared
chemical_list: D006454:Hemoglobins