title: Lipofuscin, homocysteine and tissue polypeptide specific antigen in gestational hypertension.
abstract: OBJECTIVE
  The aim of this study were to assess the levels of lipofuscin (parameter of oxidative stress), homocysteine (as a marker of vascular injury) and tissue specific antigen - TPS - (as a marker of cell proliferation) in relation to arterial pressure of pregnant woman.
  
  
  METHODS
  Healthy pregnant women (n=18), women with mild 140/90=< RR<160/100 (n=19), and severe 160/100=<RR (n=23) gestational hypertension were enrolled. Lipofuscin has been determined by fluorescence spectroscopy, homocysteine by MEIA commercial kit from Abbott IMx, TPS by EIA method using kit from BEKI.
  
  
  RESULTS
  Mean duration of gestation was 34+/-5 weeks, and there were no differences between groups. Serum lipofuscin levels in mild form of pregnancy-induced hypertension were decreased comparing to normal pregnancy. Homocysteine levels were decreased and TPS levels increased in both mild and severe gestational hypertension.
  
  
  CONCLUSIONS
  Our results suggest overestimation of the role of oxidative stress and hyperhomocysteinemia in gestational hypertension.
authors.affiliation: Department of Clinical Immunodiagnostics, Medical University of Silesia, Katowice, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Partyka
authors.forename: B
authors.initials: B
authors.lastname: Chmiel
authors.forename: Jerzy
authors.initials: J
authors.lastname: Sikora
authors.forename: T
authors.initials: T
authors.lastname: Grabowska
authors.forename: B
authors.initials: B
authors.lastname: Wróbel
authors.forename: A
authors.initials: A
authors.lastname: Praisner
authors.forename: A
authors.initials: A
authors.lastname: Pióro
authors.forename: P
authors.initials: P
authors.lastname: Jałowieicki
authors.forename: Danuta
authors.initials: D
authors.lastname: Kokocinska
mesh_terms: D001794:Blood Pressure; D003404:Creatinine / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D008062:Lipofuscin / Q000097:blood*; D018384:Oxidative Stress; D010455:Peptides / Q000097:blood*; D011247:Pregnancy
chemical_list: D008062:Lipofuscin; D010455:Peptides; C089984:tissue polypeptide specific antigen; D006710:Homocysteine; D003404:Creatinine