title: The prevalence of retinal angiomatous proliferation in age-related macular degeneration with occult choroidal neovascularization.
abstract: BACKGROUND
  The purpose of the study was to ascertain the prevalence of retinal angiomatous proliferation (RAP) by means of dynamic indocyanine green angiography (d-ICGA) in patients with newly diagnosed fibrovascular pigment epithelium detachment (type 1) or late leakage of undetermined source (type 2) occult choroidal neovascularization (CNV) on fluorescein angiography.
  
  
  METHODS
  We carried out a review of digital fluorescein and ICG angiograms obtained by confocal scanning laser ophthalmoscope (HRA; Heidelberg Engineering GmbH, Dossenheim, Germany) in 253 consecutive patients (270 eyes) with a clinical diagnosis of type 1 or type 2 occult CNV on fluorescein angiography (1998 through 2003).
  
  
  RESULTS
  Sixty eyes had type 1 and 210 eyes type 2 occult CNV on fluorescein angiography. Overall, 57 cases of RAP were identified in 54 eyes (20%) with d-ICGA. RAP was present in 6 out of 60 eyes with type 1 (10%) and in 51 out of 210 eyes with type 2 occult CNV (24%). Mean distance of the lesion from the fovea was 682 +/- 304 microm (mean +/- SD).
  
  
  CONCLUSIONS
  d-ICGA is invaluable for early diagnosis of RAP in exudative age-related macular degeneration (ARMD). In our series, up to one fourth of type 2 occult CNV were in fact RAP.
authors.affiliation: Ophthalmology Department, S. Giuseppe Hospital, Milan, Italy.
authors.forename: Amedeo L
authors.initials: AL
authors.lastname: Massacesi
authors.forename: Laura
authors.initials: L
authors.lastname: Sacchi
authors.forename: Fulvio
authors.initials: F
authors.lastname: Bergamini
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Bottoni
mesh_terms: D000368:Aged; D001163:Arteriovenous Anastomosis / Q000473:pathology*; D002199:Capillary Permeability; D020256:Choroidal Neovascularization / Q000175:diagnosis*; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008268:Macular Degeneration / Q000175:diagnosis*; D008297:Male; D015995:Prevalence; D012163:Retinal Detachment / Q000175:diagnosis; D015861:Retinal Neovascularization / Q000175:diagnosis*; D055213:Retinal Pigment Epithelium / Q000473:pathology
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green