A ubiquitin-like protein involved in membrane fusion.
Atg8 is a ubiquitin-like protein involved in autophagy in yeast that is targeted to membranes through conjugation to the lipid phosphatidylethanolamine (PE). In this issue of Cell, Nakatogawa et al. (2007) show that Atg8 conjugated to PE mediates tethering between adjacent membranes and stimulates membrane hemifusion, an event that may mimic expansion of the autophagosomal membrane during autophagy.
Subramani
Suresh
S
Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, CA 92093, USA. ssubramani@ucsd.edu
Farré
Jean-Claude
JC
D001343:Autophagy / Q000502:physiology*; D000071190:Autophagy-Related Protein 8 Family; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D008561:Membrane Fusion / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D010714:Phosphatidylethanolamines / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
C113757:ATG8 protein, S cerevisiae; D000071190:Autophagy-Related Protein 8 Family; D008869:Microtubule-Associated Proteins; D010714:Phosphatidylethanolamines; D029701:Saccharomyces cerevisiae Proteins; D025801:Ubiquitin; C483858:phosphatidylethanolamine