Venous ulcers of the lower limbs due to congenital thalidomide-related valve defect.
A 44-year-old woman with fetal thalidomide syndrome and congenital pseudoainhum of the left big toe had a 5-year history of painful nonhealing ulcers in the left malleolar region. Venous Doppler ultrasonography showed hypoagenesis of the valve flaps of the deep and superficial venous circuit. To our knowledge, this is the first description of congenital pseudoainhum associated with fetal thalidomide syndrome. The coexistence of cutaneous ulcers in our case might be coincidental but may be related to a congenital valve defect (hypoagenesis) caused by thalidomide.
Rubegni
Pietro
P
Section of Dermatology, Department of Clinical Medicine and Immunological Sciences, University of Siena, Siena, Italy. rubegni@unisi.it
Poggiali
Sara
S
Bilenchi
Roberta
R
Diana
Agnese
A
Risulo
Massimiliano
M
Civeli
Letizia
L
Fimiani
Michele
M
D000328:Adult; D005260:Female; D006349:Heart Valve Diseases / Q000139:chemically induced / Q000150:complications / Q000151:congenital; D006801:Humans; D018811:Maternal Exposure / Q000009:adverse effects*; D013723:Teratogens; D013792:Thalidomide / Q000009:adverse effects*; D018608:Ultrasonography, Doppler; D014647:Varicose Ulcer / Q000000981:diagnostic imaging / Q000209:etiology*
D013723:Teratogens; D013792:Thalidomide