title: Merkel cell carcinoma and HIV infection: a case report and review of the literature.
abstract: Merkel cell carcinoma (MCC) is a skin cancer of neuroendocrine origin that occurs most often in sun-exposed areas. In the general population, it is a disease of older adults, with only 5% of cases occurring below the age of 50 years. Immunosuppression is the significant risk factor for the development of MCC and recently it was suggested that individuals with HIV have a relative risk of 13.4 to developed MCC in comparison with the general population. We report a case of MCC in an HIV-infected patient and we review nine patients with HIV with MCC. Our patient was a 54-year-old man who came to our attention without a known HIV diagnosis. He was apparently in good health and had no risk factor for HIV, but by the atypical site of the lesion and by the relative young age of the patient we suspected a case of immunosuppression and for this reason we did HIV test that had a positive result. The patient was treated with surgery and chemotherapy but died as a result of liver metastases 25 months after his tumor was diagnosed.
authors.affiliation: Department of Dermatology, University of Brescia, Azienda Spedali Civili, Brescia, Italy. manganoni@spedalicivili.brescia.it
authors.forename: M A
authors.initials: MA
authors.lastname: Manganoni
authors.forename: C
authors.initials: C
authors.lastname: Farisoglio
authors.forename: G
authors.initials: G
authors.lastname: Tucci
authors.forename: M
authors.initials: M
authors.lastname: Venturini
authors.forename: D
authors.initials: D
authors.lastname: Marocolo
authors.forename: M C
authors.initials: MC
authors.lastname: Aquilano
authors.forename: I
authors.initials: I
authors.lastname: El-Hamad
authors.forename: V D
authors.initials: VD
authors.lastname: Ferrari
authors.forename: P G
authors.initials: PG
authors.lastname: Calzavara Pinton
mesh_terms: D015266:Carcinoma, Merkel Cell / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000821:virology*