ANP and BNP in atrial fibrillation before and after cardioversion--and their relationship to cardiac volume and function.
The role of atrial (ANP) and B-type (BNP) natriuretic peptide in atrial fibrillation (AF) is not clear. Our aim was to describe ANP and BNP in AF, and their changes following cardioversion in persistent AF. Furthermore, we wanted to assess the association between ANP and BNP and cardiac volume and function evaluated by magnetic resonance imaging. ANP and BNP decreased significantly following cardioversion. After 180 days of sinus rhythm, ANP and BNP were still significantly elevated. Same results were seen in patients with lone AF. Left and right atrial volumes correlated positively with ANP and BNP. Changes in left atrial volume were predictive of changes in ANP and BNP following cardioversion. AF may cause enduringly elevated ANP and BNP and atrial volume seems to be an important determinant of ANP and BNP in AF.
Therkelsen
Susette Krohn
SK
Groenning
Bjoern Aaris
BA
Kjaer
Andreas
A
Svendsen
Jesper Hastrup
JH
Boje Jensen
Gorm
G
D001281:Atrial Fibrillation / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D016275:Atrial Function / Q000502:physiology*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D002306:Cardiac Volume / Q000502:physiology*; D004554:Electric Countershock / Q000379:methods*; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D013997:Time Factors; D016276:Ventricular Function / Q000502:physiology*
D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor