title: Contracting in vivo research: what are the issues?
abstract: As a result of increasing internal and external pressures, research institutions are using contract research organizations for the conduct of in vivo research. Many issues arise when contracting animal research, including concern regarding animal health and welfare. Each sponsor institution should develop a program for outsourced in vivo research that evaluates and ensures appropriate care and use of research animals. Each sponsoring institution should consider establishing a policy and procedure for how outsourced in vivo studies will be approved, conducted, and monitored. An approved list of contract facilities can be established on the basis of accepted standards for animal care and use. Written contracts should include confidentiality agreements, the delineation of animal ownership, and the expectation to comply with all applicable regulations and guidelines for research animal care and use. Finally, a process for communication of adverse study or animal welfare events should be established. Thorough evaluation of contract organizations will help ensure appropriate research animal care and use.
authors.affiliation: Eli Lilly and Company, Indianapolis, IN, USA. wjunderwood@lilly.com
authors.forename: Wendy J
authors.initials: WJ
authors.lastname: Underwood
mesh_terms: D032761:Animal Experimentation / Q000941:ethics / Q000592:standards; D000827:Animal Welfare; D016208:Databases, Factual; D020416:Outsourced Services; D011786:Quality Control