[Clinical study on treatment of acute biliary tract infection with biliary drainage via endoscope combined with Chinese drug medication].
OBJECTIVE
To observe the curative effects of biliary drainage via endoscope (ENBD) combined with Chinese drug medication on acute biliary tract infection (ABTI) and the influence of treatment on complement 3 (C3), C-reactive protein (CRP) and interleukin-6 (IL-6).


METHODS
Sixteen patients with ABTI were randomly assigned to two groups: the 9 patients in the combined treatment group (CTG) treated with ENBD combined with Chinese medicine and the 7 patients in routine treatment group (RTG) treated with ENBD alone. Another 18 patients with simple gallbladder stone were taken as the control group (CG). The curative effect was observed and the serum concentrations of C3, CRP and IL-6 were determined before and after treatment.


RESULTS
Before treatment, the concentrations of CRP and IL-6 were significantly higher and C3 lower in all ABTI patients than those in patients with simple gallbladder stone (P < 0.05 or P < 0.01). After treatment, the general condition of patients was improved, the recovery time of intestinal tract function was shortened and the concentrations of C3, CRP and IL-6 significantly decreased in CTG, with the effects better than those in RTG respectively (P < 0.01 or P < 0.05).


CONCLUSIONS
ENBD combined with Chinese drug medication shows favorable curative effects on ABTI. Treatment with Chinese medicine according to syndrome differentiation could decrease blood level of pro-inflammatory cytokines and promote recovery of the injured immune function.
Liu
Liang
L
Department of Surgery, Tianjin Nankai Hospital, Tianjin. liuliang806@yahoo.com.cn
Xie
Ji-Liang
JL
Li
Ji-Kun
JK
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002761:Cholangitis / Q000097:blood / Q000628:therapy*; D003131:Combined Modality Therapy; D003176:Complement C3 / Q000378:metabolism; D004322:Drainage / Q000295:instrumentation / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016145:Endoscopy, Digestive System; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D016896:Treatment Outcome
D003176:Complement C3; D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D002097:C-Reactive Protein