title: Relation of admission white blood cell count to left ventricular remodeling after anterior wall acute myocardial infarction.
abstract: We investigated whether a high white blood cell (WBC) count on admission for acute myocardial infarction (AMI) may be associated with a higher risk of subsequent left ventricular (LV) remodeling. We included 107 patients with anterior AMI. Echocardiographic studies were performed at hospital discharge, at 3 months, and at 1 year after AMI. LV remodeling (>20% increase in end-diastolic volume) was observed in 27% of patients. WBC counts during hospitalization were higher in patients who subsequently underwent LV remodeling (p = 0.003 for WBC count on admission). The increase in end-diastolic volume from baseline to 1 year was greater for patients in the higher tertile of WBC count on admission (p = 0.04). When adjusting for baseline clinical and echocardiographic characteristics by multivariate analysis, WBC count on admission was independently associated with LV remodeling (odds ratio 1.23, 95% confidence interval 1.04 to 1.45, p = 0.018). In conclusion, a high WBC count on admission for AMI is an independent predictor of LV remodeling, even when predischarge echocardiographic variables are taken into account.
authors.affiliation: Centre Hospitalier Régional et Universitaire de Lille, Lille, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Bauters
authors.forename: Pierre V
authors.initials: PV
authors.lastname: Ennezat
authors.forename: Olivier
authors.initials: O
authors.lastname: Tricot
authors.forename: Robert
authors.initials: R
authors.lastname: Lallemant
authors.forename: Valérie
authors.initials: V
authors.lastname: Aumégeat
authors.forename: Benoit
authors.initials: B
authors.lastname: Segrestin
authors.forename: Philippe
authors.initials: P
authors.lastname: Quandalle
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lamblin
authors.forename: Christophe
authors.initials: C
authors.lastname: Bauters
mesh_terms: D003955:Diagnostic Tests, Routine; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000503:physiopathology*; D020257:Ventricular Remodeling / Q000502:physiology*