Successful treatment of ctx-m ESBL producing Escherichia coli relapsing pyelonephritis with long term pivmecillinam.
Oral therapy options for pyelonephritis caused by ESBL producing E. coli are limited. We describe a woman with relapsing pyelonephritis due to a CTX-M ESBL E. coli who was cured with a prolonged course of pivmecillinam. This suggests pivmecillinam may be effective treatment for selected patients with pyelonephritis with these organisms.
Nicolle
Lindsay E
LE
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada. lnicolle@hsc.mb.ca
Mulvey
Michael R
MR
D000328:Adult; D000561:Amdinocillin Pivoxil / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005260:Female; D006801:Humans; D011704:Pyelonephritis / Q000188:drug therapy* / Q000382:microbiology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000561:Amdinocillin Pivoxil; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases