Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening.
Although flow cytometry is viewed as a mature technology, there have been dramatic advances in analysis capabilities, sorting, sample handling and sensitivity in the past decade. These advances contribute to its application in biological and chemical diversity, sample throughput, high content, and complex systems biology. This article will evaluate the new opportunities for flow cytometry relating to receptor assembly and pharmacology, as well as a range of screening applications.
Sklar
Larry A
LA
The New Mexico Molecular Libraries Screening Center, Cancer Research and Treatment Center, The University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA. lsklar@salud.unm.edu
Carter
Mark B
MB
Edwards
Bruce S
BS
D000818:Animals; D015195:Drug Design; D005434:Flow Cytometry; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009316:National Institutes of Health (U.S.); D010316:Particle Size; D010750:Phosphoproteins / Q000378:metabolism; D014481:United States
D010750:Phosphoproteins