title: Aeroallergen sensitization in healthy children: racial and socioeconomic correlates.
abstract: OBJECTIVE
  Allergic sensitization is very prevalent and often precedes the development of allergic disease. This study examined the association of race with allergic sensitization among healthy children with no family history of atopy.
  
  
  METHODS
  Two hundred seventy-five children, predominantly from lower socioeconomic strata, from Cincinnati, Ohio, ages 2 to 18 years without a family or personal history of allergic diseases, underwent skin prick testing to 11 allergen panels. The Pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) was used to examine the impact of sensitization on quality of life.
  
  
  RESULTS
  Thirty-nine percent of healthy children were sensitized to 1 or more allergen panels. Multivariate logistic regression showed increased risk among African-American children for any sensitization (OR, 2.17; [95% CI: 1.23, 3.84]) and sensitization to any outdoor allergen (OR, 2.96 [95% CI: 1.52, 5.74]). Eighty-six percent of children had PADQLQ scores of 1 or less (0 to 6 scale).
  
  
  CONCLUSIONS
  Allergic sensitization is prevalent even among children who do not have a personal or family history of asthma, allergic rhinitis, or atopic dermatitis and who have no evidence of current, even subtle effects from this sensitization on allergic disease-related quality of life. African-American children are at greater risk for presence of sensitization, especially to outdoor allergens.
authors.affiliation: Division of Emergency Medicine, Akron Children's Hospital and Northeastern Ohio Universities College of Medicine, Akron, Ohio 44308, USA. mstevenson@chmca.org
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Stevenson
authors.forename: Stacey
authors.initials: S
authors.lastname: Sellins
authors.forename: Emilie
authors.initials: E
authors.lastname: Grube
authors.forename: Kathy
authors.initials: K
authors.lastname: Schroer
authors.forename: Jayanta
authors.initials: J
authors.lastname: Gupta
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Gurjit K
authors.initials: GK
authors.lastname: Khurana Hershey
mesh_terms: D000293:Adolescent; D000393:Air Pollutants / Q000276:immunology*; D000485:Allergens / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D005260:Female; D006304:Health Status; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D007114:Immunization; D015994:Incidence; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D011336:Probability; D044469:Racial Groups; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000208:ethnology / Q000276:immunology*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012882:Skin Tests / Q000379:methods; D012959:Socioeconomic Factors; D014505:Urban Population
chemical_list: D000393:Air Pollutants; D000485:Allergens