title: Management of premenstrual acne with Cox-2 inhibitors: a placebo controlled study.
abstract: BACKGROUND
  Premenstrual acne is poorly understood, the accepted hypothesis is 30 years old.
  
  
  OBJECTIVE
  Here we test the hypothesis that premenstrual acne can be suppressed using Cox-2 inhibitors.
  
  
  METHODS
  Eighty women with premenstrual acne were enrolled in a trial where they were given rofecoxib, a Cox-2 inhibitor or placebo for 10 days for two cycles and were evaluated using acne severity index and inflammatory acne counts.
  
  
  RESULTS
  Rofecoxib was more effective than the placebo.
  
  
  CONCLUSIONS
  Although the number studied is small, the results suggest that rofecoxib is effective in the management of premenstrual acne and that prostaglandin PGE2 may be involved in its pathogenesis.
authors.affiliation: Mallya Hospital, Bangalore, India. rustomtehrani@yahoo.co.in
authors.forename: Rustom
authors.initials: R
authors.lastname: Tehrani
authors.forename: Mala
authors.initials: M
authors.lastname: Dharmalingam