Sputum biomarkers of inflammation in cystic fibrosis lung disease.
Pulmonary biomarkers are being used more frequently to monitor disease activity and evaluate response to treatment in individuals with cystic fibrosis (CF). This article summarizes the current state of knowledge of biomarkers of inflammation relevant to CF lung disease, and the tools to measure inflammation, with specific emphasis on sputum. Sputum is a rich, noninvasive source of biomarkers of inflammation and infection. Sputum induction, through the inhalation of hypertonic saline, has expanded the possibilities for monitoring airway inflammation and infection, especially in individuals who do not routinely expectorate sputum. We critically examine the existing data supporting the validity of sputum biomarkers in CF, with an eye toward their application as surrogate endpoints or outcome measures in CF clinical trials. Further validation studies are needed regarding the variability of inflammatory biomarker measurements, and to evaluate how these biomarkers relate to disease severity, and to longitudinal changes in lung function and other clinical endpoints. We highlight the need to incorporate sputum collection, by induction if necessary, and measurement of sputum biomarkers into routine CF clinical care. In the future, pulmonary biomarkers will likely be useful in predicting disease progression, indicating the onset and resolution of a pulmonary exacerbation, and assessing response to current therapies or candidate therapeutics.
Sagel
Scott D
SD
Department of Pediatrics, The Children's Hospital and University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80218, USA. sagel.scott@tchden.org
Chmiel
James F
JF
Konstan
Michael W
MW
D015415:Biomarkers / Q000032:analysis*; D002986:Clinical Trials as Topic; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000175:diagnosis; D008171:Lung Diseases / Q000175:diagnosis; D017063:Outcome Assessment, Health Care / Q000379:methods; D015203:Reproducibility of Results; D013183:Sputum / Q000737:chemistry*
D015415:Biomarkers