title: Interaction profiling of T-cell epitopes with MHC-class I molecules.
abstract: A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We report a structural bioinformatics study of peptide-HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.
authors.affiliation: Bioinformatics Centre and Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore, India.
authors.forename: Banaja Priyardarshini
authors.initials: BP
authors.lastname: Dash
authors.forename: Sumanto
authors.initials: S
authors.lastname: Mukherjee
authors.forename: V L
authors.initials: VL
authors.lastname: Suhas
authors.forename: Nagasuma
authors.initials: N
authors.lastname: Chandra
mesh_terms: D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D018604:Epitope Mapping / Q000379:methods; D018984:Epitopes, T-Lymphocyte / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D025941:Protein Interaction Mapping
chemical_list: D018984:Epitopes, T-Lymphocyte; D015395:Histocompatibility Antigens Class I; D010455:Peptides