Computed tomography scanning in cystic fibrosis research trials: practical lessons from three clinical trials in the United States.
Over the last 15 years, several clinical trials in subjects with cystic fibrosis (CF) have employed computed tomography (CT) scanning as an outcome surrogate. These research trials have increased our knowledge about the appearance of the lungs in patients with CF, and the relationship between the CT appearance, pulmonary function tests, and clinical outcomes. In addition, practical information has been gained on the use of CT scanning in CF research trials. In this article, practical issues on the use of CT scanning in CF clinical trials are presented and specific lessons from three of these trials are discussed.
Brody
Alan S
AS
Department of Radiology, Cincinnati Children's Hospital, Cincinnati, Ohio 45229-3039, USA. alan.brody@cchmc.org
D000293:Adolescent; D000328:Adult; D002648:Child; D002986:Clinical Trials as Topic; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D018014:Gene Transfer Techniques; D006801:Humans; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D058910:Purinergic P2 Receptor Agonists; D016032:Randomized Controlled Trials as Topic; D058473:Receptors, Purinergic P2Y2; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed
C546385:P2RY2 protein, human; D058910:Purinergic P2 Receptor Agonists; D058473:Receptors, Purinergic P2Y2