title: Darier's disease following radiotherapy for carcinoma of cervix.
abstract: Darier-White disease is due to a defect in the ATP2A2 gene encoding the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2b). We report a case of carcinoma cervix in whom Darier's disease manifested after the initiation of radiation therapy. Conventional cytogenetics on peripheral blood revealed non-clonal constitutional autosomal and X chromosome abnormalities suggesting radiation induced gene toxicity. Occurrence of Darier's disease in our case could be due to treatment induced sustained differentiation in the Darier's affected skin by an unknown mechanism. Late onset or sporadic Darier's disease is the other possibility.
authors.affiliation: Tata Memorial Centre, Mumbai, India. supriyachopra@rediffmail.com
authors.forename: Supriya
authors.initials: S
authors.lastname: Chopra
authors.forename: Vinay
authors.initials: V
authors.lastname: Sharma
authors.forename: K C
authors.initials: KC
authors.lastname: Nischal
authors.forename: Uday
authors.initials: U
authors.lastname: Khopkar
authors.forename: Chanda
authors.initials: C
authors.lastname: Baisane
authors.forename: Kadam Pratibha
authors.initials: KP
authors.lastname: Amare