[Correction of free-radical processes in patients with chronic brain ischemia with intravenous laser irradiation of blood].
We examined lipid peroxidation (LPO) in 130 patients with chronic brain ischemia (CBI). Primary and secondary LPO products, oxidative and antioxidative enzymes were studied in the course of therapy with antioxidant drug cytoflavin and intravenous laser radiation of blood (ILRB). The latter proved to have a normalizing action on LPO and antioxidant defense. With progression of CBI, effects of ILRB on enzymatic activity weakens due to depletion of endogenic antioxidants. This necessitates administration of exogenic antioxidants (cytoflavin) for complex correction of free radical processes. This conclusion allows recommending combined schemes of therapy for patients with CBI stage II and III.
Karneev
A N
AN
Solov'eva
E Iu
EIu
Fedin
A I
AI
D000975:Antioxidants / Q000627:therapeutic use; D001769:Blood / Q000528:radiation effects*; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D053685:Laser Therapy; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008297:Male; D010088:Oxidoreductases / Q000097:blood / Q000528:radiation effects*
D000975:Antioxidants; D005609:Free Radicals; D010088:Oxidoreductases