title: Prognostic value of myocardial perfusion gated SPECT in patients with symptomatic intracranial large-artery atherosclerosis.
abstract: BACKGROUND
  We aimed to evaluate the prognostic value of myocardial perfusion gated SPECT in patients with symptomatic intracranial large-artery atherosclerosis (ILA).
  
  
  METHODS
  Seventy-two consecutive first-ever symptomatic ILA patients without known heart disease underwent a stress myocardial perfusion gated SPECT, and long-term follow-up was conducted thereafter.
  
  
  RESULTS
  During an average follow-up of 15.2 +/- 9 months, 9 patients (13.8%) presented major coronary events (CEs). Survival analyses (Kaplan-Meier and Cox regression) identified presence of moderate-to-severe myocardial perfusion defects (log rank p = 0.004) and ejection fraction <50% (p = 0.014) as predictors of future CEs. Neurovascular ischemic events were not predicted by SPECT variables.
  
  
  CONCLUSIONS
  Myocardial perfusion scintigraphy predicts future CEs in patients with symptomatic ILA and may be helpful to guide therapeutic strategies in this subgroup of stroke patients.
authors.affiliation: Cardiology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain. jcandell@vhebron.net
authors.forename: J
authors.initials: J
authors.lastname: Candell-Riera
authors.forename: J F
authors.initials: JF
authors.lastname: Arenillas
authors.forename: G
authors.initials: G
authors.lastname: Romero-Farina
authors.forename: S
authors.initials: S
authors.lastname: Aguadé-Bruix
authors.forename: G
authors.initials: G
authors.lastname: de León
authors.forename: J
authors.initials: J
authors.lastname: Castell-Conesa
authors.forename: C A
authors.initials: CA
authors.lastname: Molina
authors.forename: A
authors.initials: A
authors.lastname: Rovira
authors.forename: J
authors.initials: J
authors.lastname: Alvarez-Sabín
mesh_terms: D000368:Aged; D003251:Constriction, Pathologic; D003326:Coronary Circulation; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000000981:diagnostic imaging* / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000150:complications* / Q000000981:diagnostic imaging / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications* / Q000000981:diagnostic imaging / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D013318:Stroke Volume; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*