title: Anorectal motor disorders.
abstract: Anorectal motor disorders such as faecal incontinence, chronic anorectal pain and solitary rectal ulcer syndrome are common in the community. They cause psychological distress, affect quality of life, and pose a significant economic burden. In recent years, many strides have been made in the diagnostic criteria and in the mechanistic understanding of anorectal disorders. The use of innovative manometric, neurophysiological and radiological techniques have shed new light on the underlying pathophysiology. Also, it has been recognised that psychological dysfunction play an important role. However, there is a lack of consensus regarding what is abnormal, regarding the overlap between phenotypes and regarding optimal diagnostic approaches or tests. There has been little advance in drug therapy for these conditions. Although several treatments have been tried and appear promising, controlled trials are either lacking or have provided insignificant evidence. There is a need for improved medical, behavioural and surgical treatments for these conditions.
authors.affiliation: Section of Neurogastroenterology, Division of Gastroenterology-Hepatology, Department of Internal Medicine University of Iowa Carver College of Medicine & Clinical Research Center, Iowa City, IA 52242, USA.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Remes-Troche
authors.forename: Satish S C
authors.initials: SS
authors.lastname: Rao
mesh_terms: D005242:Fecal Incontinence / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D005401:Fissure in Ano / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D010146:Pain / Q000209:etiology* / Q000503:physiopathology*; D059408:Pain Management; D013577:Syndrome