Lymphotoxin-alpha gene 252A>G and metabolic syndrome features in Korean men with coronary artery disease.
BACKGROUND
Associations between variations in the lymphotoxin-alpha (LTA) gene and coronary artery disease (CAD) and type 2 diabetes have previously been reported. We investigated the influence of the LTA 252A>G and 804C>A polymorphisms on circulating parameters related to metabolic syndrome in Korean patients with CAD.


METHODS
The study subjects comprised 446 Korean male patients with CAD (age 53.9 y, BMI 25.2 kg/m2).


RESULTS
The LTA 252A>G and 804C>A polymorphisms were almost in complete linkage disequilibrium (R(2)=99.4%). The LTA 252A>G polymorphism was associated with LDL particle size (P=0.046), HOMA-IR (P=0.022) and circulating levels of triglyceride (P=0.006), HDL-cholesterol (P=0.008), apo A1 (P=0.031), insulin (P=0.046), and adiponectin (P=0.018), after adjustment for BMI. CAD patients with LTA 252G/G (n=96) had a lower concentration of HDL-cholesterol, a smaller LDL particle size, and a higher triglyceride level, compared to those with 252A/A (n=121) or 252A/G (n=229). In addition, CAD patients with LTA 252G/G had lower concentrations of adiponectin and higher levels of insulin, and HOMA-IR than those with 252A/A.


CONCLUSIONS
Homozygosity for rare alleles of the LTA 252A>G polymorphisms was associated with features of metabolic syndrome such as hyperinsulinemia, dyslipidemia, small LDL particle and low adiponectin level in CAD patients, suggesting that CAD patients with LTA 252GG are at high risk and needed an intensive intervention against further progression.
Jang
Yangsoo
Y
Division of Cardiology, Cardiovascular Genome Center, Yonsei Medical Institute, Yonsei Univ., Seoul, Republic of Korea.
Kim
Hyae Jin
HJ
Koh
Soo Jeong
SJ
Hyun
Yae Jung
YJ
Chae
Jey Sook
JS
Cho
Hongkeun
H
Ha
Jong-Won
JW
Kim
Byung-Keuk
BK
Kim
Jung-Sun
JS
Lee
Jong Ho
JH
D044466:Asian People / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000150:complications*; D005787:Gene Frequency; D006720:Homozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis* / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic
D015415:Biomarkers; D008233:Lymphotoxin-alpha