Comparative genomics: from genotype to disease phenotype in the leishmaniases.
Recent progress in sequencing the genomes of several Leishmania species, causative agents of cutaneous, mucocutaneous and visceral leishmaniasis, is revealing unusual features of potential relevance to parasite virulence and pathogenesis in the host. While the genomes of Leishmania major, Leishmania braziliensis and Leishmania infantum are highly similar in content and organisation, species-specific genes and mechanisms distinguish one from another. In particular, the presence of retrotransposons and the components of a putative RNA interference machinery in L. braziliensis suggest the potential for both greater diversity and more tractable experimentation in this Leishmania Viannia species.
Smith
Deborah F
DF
Immunology and Infection Unit, Department of Biology/Hull York Medical School, University of York, Heslington, York YO10 5YW, UK. dfs501@york.ac.uk
Peacock
Christopher S
CS
Cruz
Angela K
AK
D000818:Animals; D018503:Genome, Protozoan; D006790:Host-Parasite Interactions; D007891:Leishmania / Q000235:genetics* / Q000472:pathogenicity; D007896:Leishmaniasis / Q000382:microbiology* / Q000473:pathology; D010641:Phenotype; D018626:Retroelements; D013045:Species Specificity
D018626:Retroelements