title: Paraganglioma: report of a rare case with ovarian involvement.
abstract: We report a well-documented case of paraganglioma involving right ovary, which was initially misdiagnosed as a Sertoli-Leydig cell tumor and recurred one year later. The right ovarian tumor measured 105x90x60 mm and was associated to a subdiaphragmatic tumor measuring 80x60x35 mm, a peritoneal and a preureteral nodules measuring 10 mm either. Microscopically, tumor cells were arranged in trabeculae and cords separated by a delicate stroma. Their cytoplasm was abundant granular and eosinophilic. Their nuclei were enlarged and regular in size with coarse chromatine and a large nucleolus. The tumor expressed neuroendocrine markers (chromogranin, synaptophysin) epithelial membrane antigen and focally cytokeratin 7 and E-cadherin. Pathological ovarian paraganglioma diagnosis could be difficult but one should be aware of its bona fide existence. The clinical course is favourable in most of the cases.
authors.affiliation: Pathology Department, Salah Azaiez Institute, Bab Saadoun, Tunis, Tunisia. dhouhabacha@voila.fr
authors.forename: D
authors.initials: D
authors.lastname: Bacha
authors.forename: K
authors.initials: K
authors.lastname: Mrad
authors.forename: R
authors.initials: R
authors.lastname: Dhouib
authors.forename: M
authors.initials: M
authors.lastname: Driss
authors.forename: I
authors.initials: I
authors.lastname: Abbes
authors.forename: S
authors.initials: S
authors.lastname: Sassi
authors.forename: K
authors.initials: K
authors.lastname: Ben Romdhane
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology*; D010235:Paraganglioma / Q000473:pathology*