title: Pharyngeal narrowing in end-stage renal disease: implications for obstructive sleep apnoea.
abstract: Sleep apnoea is common in patients with end-stage renal disease (ESRD). It was hypothesised that this is related to a narrower upper airway. Upper airway dimensions in patients with and without ESRD and sleep apnoea were compared, in order to determine whether upper airway changes associated with ESRD could contribute to the development of sleep apnoea. An acoustic reflection technique was used to estimate pharyngeal cross-sectional area. Sleep apnoea was assessed by overnight polysomnography. A total of 44 patients with ESRD receiving conventional haemodialysis and 41 subjects with normal renal function were studied. ESRD and control groups were further categorised by the presence or absence of sleep apnoea (apnoea/hypopnoea index > or =10 events.h(-1)). The pharyngeal area was smaller in patients with ESRD compared with subjects with normal renal function: 3.04 +/- 0.84 versus 3.46 +/- 0.80 cm(2) for the functional residual capacity and 1.99 +/- 0.51 versus 2.14 +/- 0.58 cm(2) for the residual volume. The pharynx is narrower in patients with ESRD than in subjects with normal renal function. In conclusion, since a narrower upper airway predisposes to upper airway occlusion during sleep, it is suggested that this factor contributes to the pathogenesis of sleep apnoea in dialysis-dependent patients.
authors.affiliation: Department of Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Beecroft
authors.forename: V
authors.initials: V
authors.lastname: Hoffstein
authors.forename: A
authors.initials: A
authors.lastname: Pierratos
authors.forename: C T
authors.initials: CT
authors.lastname: Chan
authors.forename: P A
authors.initials: PA
authors.lastname: McFarlane
authors.forename: P J
authors.initials: PJ
authors.lastname: Hanly
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010614:Pharynx / Q000473:pathology*; D017286:Polysomnography; D012044:Regression Analysis; D006435:Renal Dialysis; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology