title: Selenium status indices, laboratory data, and selected biochemical parameters in end-stage renal disease patients.
abstract: We investigated the relations between selenium status (SeS) parameters, indexes of nutrition, erythropoiesis, and uremic toxemia, serum electrolytes, and other biochemical markers in end-stage renal disease (ESRD) patients, as no multivariate statistical analysis concerning all of these parameters was performed so far. SeS was evaluated by plasma Se concentration (plSe) and glutathione peroxidase (plGSHPx) activity in 69 uremic patients treated with hemodialysis (HD) and 40 healthy controls. The hierarchical multivariate partial least squares model (PLS2) was employed to establish data structure and correlations between parameters investigated. plSe and plGSHPx activity were significantly lower in patients when compared with controls (p=0.000). plSe was positively associated with indexes of erythropoiesis and nutritional status, as well as serum electrolytes and parameters of uremic toxemia. plGSHPx was inversely dependent on the pair of parameters: intact parathyroid hormone (iPTH) and aluminum plasma concentration (Al). We conclude that (1) ESRD strongly decreases selenium status and (2) the PLS2 approach revealed the existence of significant interactions among plSe, plGSHPx, and selected biochemical parameters or groups of such parameters; some of these associations need further studies to be clarified.
authors.affiliation: Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Krakow, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Zagrodzki
authors.forename: Henryk
authors.initials: H
authors.lastname: Bartoń
authors.forename: Stanisław
authors.initials: S
authors.lastname: Walas
authors.forename: Maria
authors.initials: M
authors.lastname: Fołta
authors.forename: Tomasz
authors.initials: T
authors.lastname: Stompór
authors.forename: Eve
authors.initials: E
authors.lastname: Janusz-Grzybowska
authors.forename: Maciej
authors.initials: M
authors.lastname: Drozdz
authors.forename: Władysław
authors.initials: W
authors.lastname: Sułowicz
mesh_terms: D000328:Adult; D000535:Aluminum / Q000097:blood; D001671:Biochemistry / Q000379:methods; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010281:Parathyroid Hormone / Q000097:blood; D012643:Selenium / Q000032:analysis* / Q000097:blood*
chemical_list: D010281:Parathyroid Hormone; D000535:Aluminum; D005979:Glutathione Peroxidase; D012643:Selenium