title: New lipoxygenase-inhibiting constituents from Calligonum polygonoides.
abstract: Calligonolides A (1) and B (2), two new butanolides, and a new steroidal ester, 3, have been isolated from the whole plant of Calligonum polygonoides, together with four known compounds, tetracosan-4-olide, beta-sitosterol and its glucoside, and ursolic acid. Their structures were elucidated by spectroscopic and mass-spectrometric studies. Compounds 1-3 showed moderate inhibitory potential against lipoxygenase from soybean.
authors.affiliation: International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Mirza Arfan
authors.initials: MA
authors.lastname: Yawer
authors.forename: Ejaz
authors.initials: E
authors.lastname: Ahmed
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.forename: Muhammad Azam
authors.initials: MA
authors.lastname: Rasool
authors.forename: Nighat
authors.initials: N
authors.lastname: Afza
mesh_terms: D008084:Lipoxygenase / Q000378:metabolism*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019664:Polygonaceae / Q000201:enzymology*
chemical_list: D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D008084:Lipoxygenase