title: Statistical validation of the criteria for symptom remission in schizophrenia: preliminary findings.
abstract: BACKGROUND
  Published methods for assessing remission in schizophrenia are variable and none have been definitively validated or standardized. Andreasen et al (2005) suggest systematic operational criteria using eight PANSS items for which patients must score < or = 3 (mild) for at least six months.
  
  
  METHODS
  Using data from a one year, multi-site clinical trial (n = 675) remission criteria were compared to total PANSS scores and other endpoints and demonstrate excellent agreement with overall clinical status.
  
  
  RESULTS
  Compared to total PANSS score of 60 points and other criteria, at time points > 6 months (8 and 12 months) the specificity of the remission criteria was 85%, i.e. of the patients who had a total score >60, 85% were classified as "not in remission." Sensitivity was also very high; 75% of patients with scores of <60 were classified as "in remission."Patients who dropped out of the trial were more likely not to be in remission prior to dropping out.
  
  
  CONCLUSIONS
  These findings indicate that the remission criteria are both sensitive and specific indicators of clinical status. Additional analyses are required to determine if remission status predicts other outcomes, such as employment, independent living, and prognosis.
authors.affiliation: Columbia University, Department of Psychiatry, New York, NY, USA. mark.opler@panss.org
authors.forename: Mark G A
authors.initials: MG
authors.lastname: Opler
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Yang
authors.forename: Sue
authors.initials: S
authors.lastname: Caleo
authors.forename: Philip
authors.initials: P
authors.lastname: Alberti
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D004651:Employment; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D012074:Remission Induction; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents