title: Synthesis of novel 1-pyrazolylpyridin-2-ones as potential anti-inflammatory and analgesic agents.
abstract: A new series of 4-alkyl/aryl-2-oxo-1-pyrazolyl-1,2-dihydropyridine-3-carbonitriles, pyrazolo[3,4-b]pyridine-5-carbonitriles and pyrido[2,3-d]pyrimidine-6-carbonitriles have been synthesized and tested for their anti-inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibited comparable anti-inflammatory activity to the standard (indomethacin). Compounds 5, 7a, and 8b displayed potent analgesic activity. Detailed syntheses, spectroscopic and biological data are reported.
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, Egypt. magda_f_ismail@yahoo.com
authors.forename: Magda M F
authors.initials: MM
authors.lastname: Ismail
authors.forename: Yousry A
authors.initials: YA
authors.lastname: Ammar
authors.forename: Heba S A
authors.initials: HS
authors.lastname: El-Zahaby
authors.forename: Sally I
authors.initials: SI
authors.lastname: Eisa
authors.forename: Saber
authors.initials: S
authors.lastname: El-Sayed Barakat
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D008297:Male; D010146:Pain / Q000188:drug therapy; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D011728:Pyridones