Metal-free one-pot oxidative amination of aldehydes to amides.
Metal-free oxidative amination of aromatic aldehydes in the presence of TBHP provides convenient access to amides in 85-99% under mild reaction conditions within 5 h. This method avoids free carboxylic acid intermediates and integrates aldehyde oxidation and amide bond formation, which are usually accomplished separately, into a single operation. Proline-derived amides can be prepared in excellent yields without noticeable racemization.
Ekoue-Kovi
Kekeli
K
Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
Wolf
Christian
C
D000447:Aldehydes / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis*; D000586:Amination; D010100:Oxygen / Q000737:chemistry
D000447:Aldehydes; D000577:Amides; D010100:Oxygen