title: Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a resource-limited setting (Uganda).
abstract: We describe 24 Ugandan patients with human immunodeficiency virus infection who developed symptomatic hyperlactatemia associated with the use of nucleoside analogues. All patients were receiving combination therapy that contained stavudine. The median serum lactate level was 6.6 mmol/L. All patients had their antiretroviral treatment regimen discontinued. Hospital admission was required for 5 patients. Five patients died.
authors.affiliation: Infectious Diseases Institute, Makerere University, Kampala, Uganda. pmwebsonga@yahoo.com
authors.forename: Patricia Mwebaze
authors.initials: PM
authors.lastname: Songa
authors.forename: Barbara
authors.initials: B
authors.lastname: Castelnuovo
authors.forename: Estella Birabwa
authors.initials: EB
authors.lastname: Mugasha
authors.forename: Ponsiano
authors.initials: P
authors.lastname: Ocama
authors.forename: Andrew
authors.initials: A
authors.lastname: Kambugu
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D019259:Lamivudine / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D019829:Nevirapine / Q000009:adverse effects / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D018119:Stavudine / Q000009:adverse effects / Q000627:therapeutic use; D014454:Uganda
chemical_list: D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine; D019344:Lactic Acid; D019829:Nevirapine; D018119:Stavudine