title: MiT transcription factor associated malignancies in man.
abstract: The discovery of recurrent genetic abnormalities in cancer cells has often led to the identification of novel oncogenic genes and gene families. The nature of these alterations may also offer insights into the mechanisms by which these genes mediate their oncogenic role. Amplification, translocation, deletion and point mutation are common mechanisms that result in gain- or loss-of-function of cancer associated genes. Several studies have recently demonstrated multiple genetic strategies that ultimately converge to dysregulate members of the MiT transcription factor family in cancer. The shared dependence on aberrant MiT activity thus defines an expanding family of human solid tumors.
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7295, USA. ian_davis@med.unc.edu
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Davis
authors.forename: David E
authors.initials: DE
authors.lastname: Fisher
mesh_terms: D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051739:Microphthalmia-Associated Transcription Factor / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D009857:Oncogenes / Q000235:genetics
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D051739:Microphthalmia-Associated Transcription Factor