title: Non-myeloablative transplantation for severe congenital neutropenia.
abstract: Severe Congenital Neutropenia is a rare condition characterized by a very low neutrophil count, which pre-disposes the affected child to recurrent bacterial infections. Treatment with granulocyte colony stimulating factor (G-CSF) has dramatically improved the prognosis of these children; but in patients who have become G-CSF refractory, hematopoeitic stem cell transplant is still the only effective curative treatment. We describe a patient who was unresponsive to escalating doses of G-CSF and underwent a successful reduced intensity conditioning, matched unrelated donor allograft resulting in cure.
authors.affiliation: Department of Paediatric Haematology and Oncology, Royal Liverpool Children's Hospital, Eaton Road, Liverpool, United Kingdom.
authors.forename: Jecko
authors.initials: J
authors.lastname: Thachil
authors.forename: Mark
authors.initials: M
authors.lastname: Caswell
authors.forename: Paula H B
authors.initials: PH
authors.lastname: Bolton-Maggs
authors.forename: Barry
authors.initials: B
authors.lastname: Pizer
authors.forename: Russell
authors.initials: R
authors.lastname: Keenan
mesh_terms: D002675:Child, Preschool; D016572:Cyclosporine / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000188:drug therapy; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009503:Neutropenia / Q000151:congenital* / Q000628:therapy*; D019172:Transplantation Conditioning / Q000379:methods
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D016572:Cyclosporine