Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus.
The patient was a 57-year-old white woman who presented with a 3.0 x 2.0-cm partially ulcerated vaginal polyp. Histology revealed a malignant mixed mullerian tumor composed of invasive squamous cell carcinoma with deeper areas of undifferentiated pleomorphic sarcoma. Invasive carcinoma had overlying high-grade vaginal intraepithelial neoplasia (VaIN III), which contained koilocytic atypia. In situ hybridization detected high-risk human papillomavirus DNA in both the carcinoma and the sarcoma components.
Sebenik
Matjaz
M
North Broward Medical Center, Deerfield Beach, FL 33064, USA. msebenik@yahoo.com
Yan
Zhijije
Z
Khalbuss
Walid E
WE
Mittal
Khush
K
D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008875:Middle Aged; D018200:Mixed Tumor, Mullerian / Q000737:chemistry / Q000473:pathology* / Q000601:surgery / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology*; D012509:Sarcoma / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery / Q000821:virology
D014408:Biomarkers, Tumor; D004279:DNA, Viral