Energy metabolism of bloodstream form Trypanosoma theileri.
Bloodstream form Trypanosoma theileri degrades glucose to acetate (47%) and succinate (45%) and, therefore, does not solely rely on glycolysis for ATP production. This trypanosomatid does not use amino acids for energy metabolism. These results refute the prevailing hypothesis that substrate availability determines the type of energy metabolism of trypanosomatids.
van Hellemond
Jaap J
JJ
Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80176, 3508 TD Utrecht, The Netherlands.
Hoek
Aad
A
Wichgers Schreur
Paul
P
Chupin
Vladimir
V
Ozdirekcan
Suat
S
Geysen
Dirk
D
van Grinsven
Koen W A
KW
Koets
Ad P
AP
Van den Bossche
Peter
P
Geerts
Stanny
S
Tielens
Aloysius G M
AG
D000085:Acetates / Q000378:metabolism*; D000818:Animals; D001769:Blood / Q000469:parasitology*; D002417:Cattle; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D019802:Succinic Acid / Q000378:metabolism*; D014345:Trypanosoma / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*
D000085:Acetates; D019802:Succinic Acid; D005947:Glucose