[Specific features of spontaneous carcinogenesis and survival in female mice 129/Sv PARP-1+].
Spontaneous carcinogenesis and survival were compared in female mice 129/Sv PARP-1+ and PARP-1++ controls. Survival of all animals, including that of the last 10% of mice PARP-1+ (p<0.0002), was relatively lower. It was matched by a significant rise in aging rate. Spontaneous tumor incidence was identical in both groups, although experimental animals revealed tumors at an earlier stage (612+19.2 and 706+17.6 days, respectively, (p<0.0002). The death rate of mice PARP-1+ was 67% as compared with controls (47%) (p<0.05). Tumors of uterus, ovary, liver, lung, mammary gland and soft tissues as well as malignant lymphoma were detected. Malignant tumors contributed 72% among experimental animals versus 49% in control (p<0.05). Those differences were mostly observed among uterine malignancies, adenocarcinomas of the lung and hepatocellular carcinomas. Hence, the switching-off of PARP-1+ involved accelerated aging, shorter survival and earlier and more aggressive tumor development which is in agreement with the existing views on the role played by DNA reparation in mechanisms of carcinogenesis and aging.
Piskunova
T S
TS
Iurova
M N
MN
Semenchenko
A V
AV
Zabezhinskiĭ
M A
MA
Popovich
I G
IG
Anisimov
V N
VN
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics; D005260:Female; D008136:Longevity / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000502:physiology*
C499321:Parp1 protein, mouse; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases