A novel, facile route to beta-fluoroamines by hydrofluorination using superacid HF-SbF(5).
A range of unsaturated amines and sulfonamides were converted to beta-fluoro nitrogen analogues after hydrofluorination in superacid HF-SbF(5), based on the formation of highly reactive electrophilic intermediates.
Thibaudeau
Sébastien
S
Université de Poitiers, CNRS UMR 6514, Laboratoire "Synthèse et Réactivité des Substances Naturelles", F-86022 Poitiers Cedex, France. sebastien.thibaudeau@univ-poitiers.fr
Martin-Mingot
Agnès
A
Jouannetaud
Marie-Paule
MP
Karam
Omar
O
Zunino
Fabien
F
D000498:Allyl Compounds / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis*; D000965:Antimony / Q000737:chemistry; D005459:Fluorides / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D006858:Hydrofluoric Acid / Q000737:chemistry
D000498:Allyl Compounds; D000588:Amines; D006845:Hydrocarbons, Fluorinated; D000965:Antimony; D005459:Fluorides; D006858:Hydrofluoric Acid