Ossifying fibromyxoid tumor of soft parts with clonal chromosomal aberrations.
Ossifying fibromyxoid tumor (OFMT) is a rare but morphologically distinctive soft-tissue tumor. The histologic origin of this tumor is not clearly known, but its various features suggest a schwannian, neuronal, or chondroid origin. We herein report a case of a typical OFMT that occurred in the shoulder of a 65-year-old man. The karyotype exhibited the following complex numeric and structural aberrations: 42 approximately 46,XY,-Y,add(1)(q42),add(6)(p21),t(10;18)(q26;q11),der(11)t(11;15)(q23;q15),add(12)(q13),ins(14;?)(q13;?),-15,+mar. Combined with several previously reported studies, these aberrations could not identify a common cytogenetic abnormality in OFMT.
Kawashima
Hiroyuki
H
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510 Japan. inskawa@med.niigata-u.ac.jp
Ogose
Akira
A
Umezu
Hajime
H
Hotta
Tetsuo
T
Tohyama
Tsuyoshi
T
Tsuchiya
Masahiko
M
Endo
Naoto
N
D000368:Aged; D002869:Chromosome Aberrations; D002879:Chromosomes, Human, Pair 10; D002887:Chromosomes, Human, Pair 18; D002999:Clone Cells; D020732:Cytogenetic Analysis; D005350:Fibroma / Q000235:genetics*; D020440:Gene Duplication; D006801:Humans; D008297:Male; D009999:Ossification, Heterotopic / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics*