[Clinical study on effect of Shenqi Fuzheng Injection on erythrocyte immunity in patients after cardiopulmonary bypass].
OBJECTIVE
To study the effect of Shenqi Fuzheng Injection (SQFZI) on erythrocyte immune function in patients after cardiopulmonary bypass (CPB).


METHODS
Twenty patients ready for receiving CPB were randomly assigned to two groups, 10 in each group. Patients in the SQFZI group were treated with 250 mL SQFZI via intravenous dripping starting from 5 days before operation and after ending CPB once a day. Peripheral venous blood samples of all patients were collected at the time points of before anesthesia, and 6 h, 24 h, 72 h and 7 days after CPB, which were anticoagulated with heparin for dynamically detecting the changes of RBC-C3bRR and RBC-ICR.


RESULTS
RBC-C3bRR and RBC-ICR in the SQFZI group were significantly higher at 6 h, 24 h, 72 h, and day 7 after operation than those in the control group respectively at the corresponding time points, and they restored to the normal levels at day 7, suggesting the erythrocyte immune function after CPB in the SQFZI group was superior to that in the control group (P < 0.05).


CONCLUSIONS
Application of SQFZI in the peri-operative period can significantly improve the hypo-immunological function of erythrocyte caused by CPB, and promote the recovery of erythrocyte immunity.
Song
Yi
Y
Department of Cardiosurgery, Qilu Hospital, Shandong University, Jinan. songyimd@hotmail.com
Li
Ran
R
Gong
Xing-Jun
XJ
D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D004912:Erythrocytes / Q000187:drug effects* / Q000276:immunology; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; C521737:shenqi fuzheng