title: The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors.
abstract: Paracetamol analgesic mechanism of action is still poorly defined but mainly involves central inhibition of cyclooxygenases. Here we tested the peripheral antinociceptive effects of paracetamol (intraplantar injections) in a rat model of neuropathic pain. Paracetamol dose-dependently decreased mechanical allodynia and lowered nociceptive scores associated with hyperalgesia testing. These effects were inhibited by the administration of cannabinoid CB(1) (AM251) and CB(2) (AM630) receptor antagonists. The participation of the peripheral cannabinoid system in paracetamol analgesia is suggested.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Université de Montréal - CHUM, 3840 rue St-Urbain, Montréal, H2W 1T8, Québec, Canada.
authors.forename: Mélina
authors.initials: M
authors.lastname: Dani
authors.forename: Josée
authors.initials: J
authors.lastname: Guindon
authors.forename: Chantal
authors.initials: C
authors.lastname: Lambert
authors.forename: Pierre
authors.initials: P
authors.lastname: Beaulieu
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D063387:Cannabinoid Receptor Antagonists; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006614:Hindlimb / Q000294:innervation; D006358:Hot Temperature / Q000009:adverse effects; D006930:Hyperalgesia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D007211:Indoles / Q000494:pharmacology; D008297:Male; D009437:Neuralgia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D010147:Pain Measurement / Q000379:methods; D010880:Piperidines / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors / Q000502:physiology; D043885:Receptor, Cannabinoid, CB2 / Q000037:antagonists & inhibitors / Q000502:physiology; D043882:Receptors, Cannabinoid / Q000502:physiology*; D012584:Sciatic Nerve / Q000293:injuries
chemical_list: D018712:Analgesics, Non-Narcotic; D001095:Arachidonic Acids; D063387:Cannabinoid Receptor Antagonists; D007211:Indoles; D010880:Piperidines; D011720:Pyrazoles; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2; D043882:Receptors, Cannabinoid; D000082:Acetaminophen; C103505:AM 251; C094023:iodopravadoline; C107594:N-(4-hydroxyphenyl)arachidonylamide