Evidence of immune tolerance to blood group antigens in a case of ABO-incompatible pediatric liver transplantation.
In a 12-year-old patient with blood group O, who had received a partial liver graft 10 years ago from his father with blood group A, the levels of anti-A-specific antibodies (Abs) were persistently undetectable after the transplantation, while the levels of anti-B-specific Abs gradually increased and attained a plateau. Peripheral blood mononuclear cells (PBMCs) from this patient were engrafted into NOD/SCID mouse in order to investigate the immune response to donor-type blood group antigens. Even after sensitization with blood group-A erythrocytes, no anti-A Abs were detected in the serum samples of the mouse that received PBMCs from the blood group-O recipient of group-A liver allograft, however, immunoglobulins specific for antigens other than the A antigens were produced. Thus, we provide a possible evidence of immune tolerance to blood group antigens in this ABO-incompatible pediatric liver transplantation.
Ohdan
H
H
Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. hohdan@hiroshima-u.ac.jp
Zhou
W
W
Tanaka
Y
Y
Irei
T
T
Fuchimoto
Y
Y
Egawa
H
H
Asahara
T
T
D000017:ABO Blood-Group System / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D001656:Biliary Atresia / Q000601:surgery; D001787:Blood Group Incompatibility / Q000097:blood / Q000276:immunology* / Q000473:pathology; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007150:Immunohistochemistry; D016031:Liver Transplantation / Q000276:immunology* / Q000473:pathology; D008297:Male
D000017:ABO Blood-Group System