Heme oxygenase-1: a fundamental guardian against oxidative tissue injuries in acute inflammation.
Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (HO-1), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.
Takahashi
T
T
Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama, Japan. takatoru@cc.okayama-u.ac.jp
Shimizu
H
H
Morimatsu
H
H
Inoue
K
K
Akagi
R
R
Morita
K
K
Sassa
S
S
D000208:Acute Disease; D000818:Animals; D006418:Heme / Q000378:metabolism*; D051547:Heme Oxygenase-1 / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000201:enzymology* / Q000517:prevention & control*; D018384:Oxidative Stress
D006418:Heme; D051547:Heme Oxygenase-1