title: Neuronal replacement in microcircuits of the adult olfactory system.
abstract: The local-circuit inhibitory interneurons containing gamma-aminobutyric acid (GABA) are continuously replaced in the adult olfactory bulb. Here, we describe how the production of new GABAergic interneurons is adapted to experience-induced plasticity. In particular, we discuss how such an adaptation is sensitive to the level of sensory inputs and how, in turn, neurogenesis may adjust the neural network functioning to optimize processing of sensory information. Finally, this review brings together recently described properties of interneurons as well as emerging principles of their functions that indicate a much more complex role for these cells than just that of gatekeepers providing inhibition.
authors.affiliation: Laboratoire de perception et mémoire, CNRS URA 2182, départment de neuroscience, Institut Pasteur, 25, rue du Docteur-Roux, 75724 Paris cedex 15, France. pmlledo@pasteur.fr
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Lledo
authors.forename: Françoise
authors.initials: F
authors.lastname: Lazarini
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D047108:Embryonic Development / Q000502:physiology; D005260:Female; D007395:Interneurons / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology* / Q000637:transplantation*; D009833:Olfactory Pathways / Q000166:cytology* / Q000502:physiology*; D011247:Pregnancy; D051381:Rats