title: Clinical evaluation of platelet-rich plasma and bioactive glass in the treatment of intra-bony defects.
abstract: BACKGROUND
  There are limited numbers of studies focused on the using of platelet-rich plasma (PRP) combined with different types of bone substitutes in intra-bony defects.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the effect of bioactive glass graft material (BG) with and without PRP on the clinical healing of intra-bony defects.
  
  
  METHODS
  Twenty-nine intra-bony defects were randomly treated with either PRP/BG or BG alone. Clinical parameters were recorded at baseline and repeated 9 months after surgery and surgical reentries were also performed.
  
  
  RESULTS
  The results showed that both treatment modalities were effective. Pocket depth reduction of 3.60 +/- 0.51 mm, clinical attachment gain of 3.3 +/- 1.77 mm and defect fill of 3.47 +/- 0.53 mm were noted in the PRP/BG group, with 3.29 +/- 1.68, 2.86 +/- 1.56 and 3.36 +/- 0.55 mm improvements, respectively, noted for the BG group. None of the differences between the two treatment modalities were statistically significant.
  
  
  CONCLUSIONS
  It is suggested that both PRP/BG combination and BG alone are effective in the treatment of intra-bony defects. The results also showed that using PRP with BG has no additional benefit in the reduction of pocket depth, clinical attachment gain and defect fill.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, University of Hacettepe, Ankara, Turkey.
authors.forename: Becen
authors.initials: B
authors.lastname: Demir
authors.forename: Dilek
authors.initials: D
authors.lastname: Sengün
authors.forename: Atilla
authors.initials: A
authors.lastname: Berberoğlu
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002516:Ceramics / Q000627:therapeutic use*; D003774:Dental Plaque Index; D005260:Female; D006801:Humans; D008297:Male; D017622:Periodontal Attachment Loss / Q000601:surgery; D010510:Periodontal Diseases / Q000601:surgery*; D010512:Periodontal Index; D053657:Platelet-Rich Plasma; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; C022107:Bioglass; D018786:Bone Substitutes