TRAF proteins in CD40 signaling.
The tumor necrosis factor receptor (TNFR) superfamily molecule CD40 is expressed by a wide variety of cell types following activation signals, and constitutively on B lymphocytes, macrophages, and dendritic cells. CD40 signals to cells stimulate kinase activation, gene expression, production of a antibody and a variety of cytokines, expression or upregulation of surface molecules, and protection or promotion of apoptosis. Initial steps in CD40-mediated signal cascades involve the interactions of CD40 with various members of the TNFR-associated factor (TRAF) family of cytoplasmic proteins. This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions.
Bishop
Gail A
GA
Department of Microbiology, Interdisciplinary Graduate Program in Immunology, University of Iowa and the Iowa City VAMC, Iowa City, Iowa 52242, USA. gail-bishop@uiowa.edu
Moore
Carissa R
CR
Xie
Ping
P
Stunz
Laura L
LL
Kraus
Zachary J
ZJ
D000818:Animals; D019013:CD40 Antigens / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000276:immunology*; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000502:physiology*
D019013:CD40 Antigens; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins