title: Ocular problems in Brazilian patients with AIDS before and in highly active antiretroviral therapy (HAART) era.
abstract: This study determined the total frequency of patients with AIDS and ophthalmologic problems before and after the introduction of combined highly active antiretroviral therapy (HAART), regardless of the use of this treatment; it also determined the frequency of external ocular diseases, intraocular infections and inflammations, and problems of the anterior portion of the optic nerve in these two groups of patients; and it determined the differences in the frequency of ophthalmologic problems in patients receiving HAART or not. This was a retrospective study of 207 patients examined using the same protocol, from June 1995 to February 1998 (n=58, pre-HAART era) and from March 1998 to May 2005 (n=149, HAART era). The frequency of ophthalmologic problems was significantly higher in the pre-HAART group, with a predominance of intraocular infections and inflammations. Comparison of patients receiving HAART or not revealed that ocular involvement tended to be reduced in the treated group and that treatment was effective in preventing infectious diseases; however, the prevalence of external ocular diseases was similar in the patients receiving HAART or not. As a consequence of HAART, we observed a reduction in the frequency of ocular problems, especially intraocular infections and inflammations. However, this benefic influence was less important in the ocular surface or in external ocular disease.
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, University of São Paulo, 14048-900 Ribeirão Preto, SP, Brazil.
authors.forename: Marcia Lopes
authors.initials: ML
authors.lastname: Rodrigues
authors.forename: Maria de Lourdes Veronese
authors.initials: Mde L
authors.lastname: Rodrigues
authors.forename: José Fernando de Castro
authors.initials: JF
authors.lastname: Figueiredo
authors.forename: João Alberto Holanda
authors.initials: JA
authors.lastname: de Freitas
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005128:Eye Diseases / Q000150:complications* / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies