[Particular features of steroid-induced osteoporosis].
Glucocorticoid-induced osteoporosis (GIOP) is characterized by disturbed bone remodelling with consequent reduced bone mass and abnormally low quality of the bone tissue, resulting in an elevated risk of fracture. Glucocorticoids (GC) inhibit processes of bone formation and accelerate bone degradation, all of which must be taken into account especially in the case of long-term treatment with GC. Appropriate diagnostic procedures must be implemented early in the treatment and throughout the course, as must any preventive (improvement of general condition, calcium, vitamin D) and curative treatment required. When indications are carefully observed and the dosage is constantly checked and adjusted as needed, however, GC are not only helpful and beneficial in the treatment of the basic illnesses they are prescribed for, but on balance can even have a positive effect on bone in phases of high inflammatory activity.
Hein
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Rheumatologie & Osteologie, Klinik für Innere Medizin III des Klinikums der Friedrich-Schiller-Universität, 07740 Jena. gert.hein@med.uni-jena.de
D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced* / Q000175:diagnosis* / Q000517:prevention & control
D005938:Glucocorticoids