title: Delivery of superparamagnetic nanoparticles for local chemotherapy after intraarterial infusion and magnetic drug targeting.
abstract: BACKGROUND
  Superparamagnetic nanoparticles are currently used as contrast agents for magnetic resonance imaging. These particles can also be used as drug carriers for local chemotherapy, called magnetic drug targeting. Using an external magnetic field, colloidal nanoparticles can be directed to a specific body compartment (i.e. tumor).
  
  
  METHODS
  After magnetic drug targeting in an experimental rabbit model with a VX2 squamous cell carcinoma, tumor tissue was extracted and embedded in paraffin for histology and X-ray imaging.
  
  
  RESULTS
  The distribution of magnetic nanoparticles was detected holistically with X-ray imaging and in detail using Prussian blue staining of histological cross sections.
  
  
  CONCLUSIONS
  The biodistribution of magnetic nanoparticles can be visualized with X-ray imaging and histologically confirmed.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Erlangen-Nürnberg, Germany. C.Alexiou@web.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Alexiou
authors.forename: Roland
authors.initials: R
authors.lastname: Jurgons
authors.forename: Christian
authors.initials: C
authors.lastname: Seliger
authors.forename: Oliver
authors.initials: O
authors.lastname: Brunke
authors.forename: Heinrich
authors.initials: H
authors.lastname: Iro
authors.forename: Stefan
authors.initials: S
authors.lastname: Odenbach
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000188:drug therapy; D016503:Drug Delivery Systems / Q000379:methods*; D007261:Infusions, Intra-Arterial; D008280:Magnetics; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011817:Rabbits; D011859:Radiography; D014018:Tissue Distribution; D014965:X-Rays