Somatostatin-receptor positive brain stem glioma visualized by octreoscan.
In diffuse brainstem gliomas often surgical biopsies cannot be obtained. The diagnosis relies upon imaging criteria, first line being MRI. Gliomas generally express somatostatin receptors (SSTR), which might enable receptor imaging. We present the case of a female adolescent with acute onset of hallucinations, dysphagia and diplopia. MRI detected a suggestive large pontine glioma. This lesion presented with marked In-111-pentreotide tracer uptake. SSTR-scan provided information about SSTR-expression, tumour viability and extension. Radiopeptide therapy for selected patients might be discussed.
Pichler
Robert
R
Pichler
Josef
J
Mustafa
Hamdy
H
Nussbaumer
Karin
K
Zaunmüller
Thomas
T
Topakian
Raffi
R
D000328:Adult; D020295:Brain Stem Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging*; D006801:Humans; D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin / Q000032:analysis*; D013004:Somatostatin / Q000031:analogs & derivatives*; D015899:Tomography, Emission-Computed, Single-Photon
D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; D013004:Somatostatin; C081788:pentetreotide