[Roles of 20-HETE on physiologic and pathologic regulation in organism].
Twenty years ago, some foreign-investigators reported that omega-hydroxylation of arachidonic acid (AA) was catalyzed by cytochrome P-450 enzymes in some tissue to 20-hydroxyeicosatetraenoic acid (20-HETE). As a second messenger, it plays a pivotal role in the regulation of vascular tone, renal function, cerebral blood flow and lung vasodilator. Exogenous administeration of 20-HETE also plays an important role in the regulation of the coronary circulation. Moreover, hypertension, toxemia of pregnancy and other diseases is related to the formation of the 20-HETE. However, there is few domestic report about 20-HETE. Therefore, the domestic investigators should be given attention to 20-HETE adequately in the future. In this paper, roles of 20-HETE on physiologic and pathologic regulation in organism were reviewed.
Zhang
Di
D
Department of Physiology, School of Life Science, Northeast Normal University, Changchun 130024, China.
Huo
Hong-Liang
HL
Zhang
Ying-Ni
YN
Zeng
Qing-Hua
QH
D000818:Animals; D005260:Female; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000502:physiology*; D006973:Hypertension / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D011225:Pre-Eclampsia / Q000503:physiopathology; D011247:Pregnancy; D014666:Vasomotor System / Q000502:physiology*
D006893:Hydroxyeicosatetraenoic Acids; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid