The role of PET/CT in Cogan's syndrome.
We report on the case of a 60-year-old woman with complaints of fatigue, coughing, anorexia, atypical chest pain, recurrent fever, and also ear pain and hearing loss. A test for anti-neutrophil cytoplasmic antibody (ANCA) was myeloperoxidase positive with p-ANCA specificity. Laboratory acute phase parameters were increased. A 2-deoxy-2-[(18)F]fluoro-D: -glucose positron emission tomography/computed tomography investigation showed pathological uptake in the aorta ascendens, with no other involvement of the large vessels. After therapy with methylprednisolon intravenously and later prednisolon orally with methothrexate, her general condition and hearing loss improved both subjectively and objectively. "Atypical" Cogan's syndrome was diagnosed on the basis of sensorineural deafness with improvement on steroids and large-vessel vasculitis of the aortic arch.
Balink
H
H
Department of Nuclear Medicine, Medical Centre Leeuwarden, P.O. Box 850, 8901, BR, Leeuwarden, The Netherlands. hans.balink@znb.nl.
Bruyn
G A W
GAW
Department of Rheumatology, Medical Centre Leeuwarden, P.O. Box 850, 8901, BR, Leeuwarden, The Netherlands.
D003937:Diagnosis, Differential; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007634:Keratitis / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D013577:Syndrome; D014057:Tomography, X-Ray Computed / Q000379:methods*