[The relationship between high-sensitivity C-reactive protein and peripheral artery disease].
OBJECTIVE
To investigate the association between high-sensitivity C-reactive protein and peripheral arterial disease.


METHODS
The study population comprised 643 subjects aged at least 40 years in whom both CRP and ankle-brachial index were measured. The survey included information on demographic characteristics, clinical examinations and ankle-brachial index (ABI). Ankle-brachial index (ABI) < 0.9 was diagnostic of PAD.


RESULTS
64 subjects (10%) were diagnosed as PAD. The prevalence of current smoking, hypertension, diabetes, low HDL cholesterol and history of cardiovascular disease in the participants with PAD were higher than without (P < 0.05). The prevalence of hypertension, diabetes, and history of cardiovascular disease was higher in subjects with high CRP (P < 0.05). In logistic regression analyses, the moderate CRP group and high CRP group had a two-fold higher OR compared with the low CRP group. The P-trend across CRP groups was statistically significant (P = 0.036). High log-transformed hs-CRP level was significantly related to PAD after adjustment for the cardiovascular risk factors mentioned above (P = 0.007).


CONCLUSIONS
hs-CRP is related to PAD and high level hs-CRP is an independent risk factor for PAD in Chinese adults aged 40 years and more.
Liu
Hao
H
Department of Preventive Medicine, Medical College, Tongji University, Shanghai 200092, China.
Yu
Jin-Ming
JM
Li
Jue
J
Tian
Ju-Long
JL
Zhang
Ru-Lin
RL
Cui
Si-Fang
SF
Tong
Qi-Guang
QG
Zheng
Li-Qiang
LQ
Luo
Ying-Yi
YY
Li
Xian-Kai
XK
Hu
Da-Yi
DY
D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000453:epidemiology*; D002097:C-Reactive Protein / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000453:epidemiology*; D012307:Risk Factors
D002097:C-Reactive Protein