Anti-leishmanial and immunomodulatory activities of extracts from Portulaca hirsutissima and Portulaca werdermannii.
Ethyl acetate and chloroform extracts from aerial parts of Portulaca werdermannii and P. hirsutissima were tested in lymphoproliferation assays and axenic cultures of Leishmania amazonensis and Trypanosoma cruzi. Both extracts of P. werdermannii and P. hirsutissima had a potent inhibitory activity on lymphocyte proliferation. On the contrary, only the chloroformic extract of both plants inhibited L. amazonensis growth, without effect on T. cruzi cultures. These results indicate these Portulaca species as potential sources of new active molecules for the treatment of leishmaniasis and immune-mediated pathologies.
Costa
José Fernando Oliveira
JF
Laboratório de Engenharia Tecidual e Imunofarmacologia, Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz, Salvador, Bahia, Brazil. jfernando@cpqgm.fiocruz.br
Kiperstok
Alice Costa
AC
David
Juceni Pereira de Lima
JP
David
Jorge Maurício
JM
Giulietti
Ana Maria
AM
de Queiroz
Luciano Paganucci
LP
dos Santos
Ricardo Ribeiro
RR
Soares
Milena Botelho Pereira
MB
D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D049109:Cell Proliferation; D005260:Female; D007155:Immunologic Factors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects; D007898:Leishmaniasis, Visceral / Q000188:drug therapy; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031822:Portulaca; D014349:Trypanosoma cruzi / Q000187:drug effects
D000981:Antiprotozoal Agents; D007155:Immunologic Factors; D010936:Plant Extracts