Total synthesis of phenylpropanoid glycosides, grayanoside A and syringalide B, through a common intermediate.
Phenylpropanoid glycosides are known as bioactive natural products. Two of them, grayanoside A (1) and syringalide B (2), were synthesized through a common intermediate, using benzyl as temporary protecting group following a shorter route.
Das
Saibal Kumar
SK
Discovery Chemistry, Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500 049, AP, India. saibalkumardas@drreddys.com
Reddy
K Anantha
KA
Mukkanti
K
K
D002109:Caffeic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002621:Chemistry / Q000379:methods; D005947:Glucose / Q000737:chemistry; D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008969:Molecular Sequence Data; D024301:Plant Bark / Q000378:metabolism; D010946:Plants, Medicinal; D011714:Pyrans / Q000737:chemistry; D017382:Reactive Oxygen Species
C504009:2-(4-hydroxyphenyl)ethyl 4-O-feruloylglucopyranoside; D002109:Caffeic Acids; D005960:Glucosides; D006027:Glycosides; D011714:Pyrans; D017382:Reactive Oxygen Species; C524869:grayanoside A; D005947:Glucose