[Effects of alligator Zhikegao on relieving cough dispelling phlegm and anti-inflammation].
OBJECTIVE
To research the effects of Alligator Zhikegao on relieving cough, dispelling phlegm and anti-inflammation.


METHODS
The coughing tests in mice, the phenol red secreting tests in mice, ear edema tests in mice,and paw edema tests and subcutaneous cotton ball granuloma in rats were adopted for observing the related pharmacological effects of Alligator Zhikegao.


RESULTS
Alligator Zhikegao could obviously prolong the latent period and decrease the times of mouse coughing, and remarkably inhibit the mouse ear edema (P < 0.001), the rat paw edema and the hyperplasia of subcutaneous cotton ball granuloma in rats. Alligator Zhikegao 11.70 g x kg(-1) could significant improve the carbonic clearances of macrophages (P <0.05) and the hemolysin level in serum (P <0.01).


CONCLUSIONS
Alligator Zhikegao has significant effects on relieving cough, dispelling phlegm, anti-inflammation and immunological regulation.
Xu
Dong-Hui
DH
Lab. of Traditional Chinese Medicine and Marine Drugs, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. dong-huixu@yahoo.com.cn
Luo
Zhao-Zhang
ZZ
Mei
Xue-Ting
XT
Ma
Hai-Ping
HP
Zeng
Jun-Ling
JL
Xu
Shi-Bo
SB
D000489:Alligators and Crocodiles; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000627:therapeutic use; D000996:Antitussive Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D003371:Cough / Q000188:drug therapy; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use; D004427:Ear Diseases / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy; D005100:Expectorants / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D006025:Glycosaminoglycans / Q000302:isolation & purification / Q000627:therapeutic use*; D006099:Granuloma / Q000188:drug therapy; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000627:therapeutic use*; D008516:Medicine, Chinese Traditional; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000996:Antitussive Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005100:Expectorants; D006025:Glycosaminoglycans; D008419:Materia Medica