Biphagic pulmonary blastoma with a lesion of yolk sac tumor.
Biphagic pulmonary blastoma (BPB) is one of the rare pulmonary malignant neoplasms. Here, we describe a case of BPB with a histological feature of yolk sac tumor, accompanied with an elevated serum alpha-fetoprotein level (531.1 ng/ml). The tumor was detected in the right upper lobe as a 10-cm mass. The patient underwent right upper lobectomy and mediastinal lymph node dissection. Histological examination revealed that the tumor was composed of immature mesenchymal and epithelial elements, and it was accompanied by foci of yolk sac tumor-like features that showed positive staining for alpha-fetoprotein antibody. Adjuvant chemotherapy consisted of cisplatin and etoposide. After surgery, the serum level of alpha-fetoprotein decreased below normal. Local recurrence was disclosed 27 months after surgery, and radiation therapy was performed. The patient is currently alive 70 months after surgery.
Oshika
Yoshiro
Y
Department of Thoracic and Cardiovascular Surgery, Japan Self-Defence Force Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan. yoshika@s00.itscom.net
Matsukuma
Susumu
S
Hashimoto
Hiroshi
H
Takeo
Hiroaki
H
Sato
Kimiya
K
Tanaka
Yoshiaki
Y
D003131:Combined Modality Therapy; D018240:Endodermal Sinus Tumor / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018202:Pulmonary Blastoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins