title: [Towards an integrated cellular and molecular: definition of breast cancers].
abstract: Breast cancer is a major health problem as well as scientifically poorly understood. Our knowledge of breast cancer is however rapidly progressing in several directions. First, genomic studies are establishing a new molecular classification of breast cancers. Molecular subtypes have been identified and are being associated with the histoclinical forms of breast cancers. Second, genetic alterations are discovered and classified, generating new potential therapeutical targets. Third, mammary stem cells have been identified in the normal mammary epithelium. Their altered counterparts have been identified in tumors and are being characterized. These combined studies allow a new integrated cellular and molecular definition of breast cancers and a conceptual basis that will help the management of the disease.
authors.affiliation: UMR 599 Inserm, Institut Paoli-Calmettes, Laboratoire d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille et Université de la Méditerranée, 27, boulevard Leï Roure, 13009 Marseille, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Charafe-Jauffret
authors.forename: Max
authors.initials: M
authors.lastname: Chaffanet
authors.forename: François
authors.initials: F
authors.lastname: Bertucci
authors.forename: Christophe
authors.initials: C
authors.lastname: Ginestier
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Jacquemier
authors.forename: Odile
authors.initials: O
authors.lastname: deLapeyrière
authors.forename: Daniel
authors.initials: D
authors.lastname: Birnbaum
mesh_terms: D001940:Breast / Q000473:pathology / Q000503:physiopathology; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006412:Hematopoietic Stem Cells / Q000473:pathology / Q000502:physiology; D006801:Humans