In preterm neonates, is the risk of developing bronchopulmonary dysplasia influenced by the failure to protect total parenteral nutrition from exposure to ambient light?
Light-exposed total parenteral nutrition (TPN) generates peroxides that contribute to an oxidant load. Shielding TPN from light protects against lung remodelling. In preterm infants, photoprotection of TPN is associated with a 30% reduction in bronchopulmonary dysplasia in a post-hoc analysis. This analysis provides justification for a randomized controlled trial.
Chessex
Philippe
P
Division of Neonatology, Children's and Women's Health Centre of British Columbia, and University of British Columbia, Vancouver, British Columbia, Canada. pchessex@cw.bc.ca <pchessex@cw.bc.ca>
Harrison
Adele
A
Khashu
Minesh
M
Lavoie
Jean-Claude
JC
D001997:Bronchopulmonary Dysplasia / Q000401:mortality* / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008027:Light / Q000009:adverse effects*; D008297:Male; D010289:Parenteral Nutrition, Total / Q000009:adverse effects* / Q000379:methods; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate