title: Acute colonic pseudo-obstruction.
abstract: Acute colonic pseudo-obstruction (ACPO) is a syndrome of massive dilation of the colon without mechanical obstruction that develops in hospitalised patients with serious underlying medical and surgical conditions. ACPO is associated with significant morbidity and mortality, and, therefore, requires urgent gastroenterologic evaluation. Appropriate evaluation of the markedly distended colon involves excluding mechanical obstruction and other causes of toxic megacolon such as Clostridium difficile infection, and assessing for signs of ischemia and perforation. Increasing age, cecal diameter, delay in decompression, and status of the bowel significantly influence mortality, which is approximately 40% when ischemia or perforation is present. The risk of colonic perforation in ACPO increases when cecal diameter exceeds 12cm and when the distention has been present for greater than 6days. Appropriate management includes supportive therapy and selective use of neostigmine and colonoscopy for decompression. Early recognition and management are critical in minimising complications.
authors.affiliation: Division of Gastroenterology, Digestive Disease Center, University of Washington Medical Center, 1959 NE Pacfiic Avenue, Box 356424, Seattle, WA 98195, USA. michaels@medicine.washington.edu
authors.forename: Michael D
authors.initials: MD
authors.lastname: Saunders
mesh_terms: D000208:Acute Disease; D003112:Colonic Pseudo-Obstruction / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D003113:Colonoscopy; D019299:Decompression, Surgical; D006801:Humans; D009388:Neostigmine / Q000627:therapeutic use; D010277:Parasympathomimetics / Q000627:therapeutic use
chemical_list: D010277:Parasympathomimetics; D009388:Neostigmine