title: Apophysomyces elegans causing acute otogenic cervicofacial zygomycosis involving salivary glands.
abstract: Zygomycosis is an invasive, life threatening fungal infection that usually affects immunocompromised hosts. In the head and neck region, rhino-orbito-cerebral zygomycosis is more common than the cervicofacial variety. We report the first case of otogenic cervicofacial zygomycosis caused by Apophysomyces elegans involving the salivary glands, an uncommon site of infection. The case began after a trivial trauma in a diabetic patient and despite surgical debridement and liposomal amphotericin B therapy, the patient died due to extensive involvement and metabolic/hemodynamic complications.
authors.affiliation: Neuro-Otology Unit, Department of Neuro-Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India. meetugoyal@yahoo.com
authors.forename: Amit
authors.initials: A
authors.lastname: Goyal
authors.forename: Isha
authors.initials: I
authors.lastname: Tyagi
authors.forename: Rajan
authors.initials: R
authors.lastname: Syal
authors.forename: R S K
authors.initials: RS
authors.lastname: Marak
authors.forename: Jagdeep
authors.initials: J
authors.lastname: Singh
mesh_terms: D000208:Acute Disease; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D048909:Diabetes Complications; D005158:Facial Paralysis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009090:Mucorales / Q000145:classification / Q000302:isolation & purification*; D009091:Mucormycosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D010031:Otitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D010306:Parotid Gland / Q000382:microbiology / Q000473:pathology; D010309:Parotitis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D012469:Salivary Glands / Q000382:microbiology / Q000473:pathology; D012793:Sialadenitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B