title: Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan.
abstract: We measured the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), non-ortho coplanar polychlorinated biphenyls (non-ortho PCBs), and mono-ortho coplanar polychlorinated biphenyls (mono-ortho PCBs) in blood collected between 2002 and 2004 from 195 pregnant women living in Sapporo City of Hokkaido Prefecture, Japan. The present study is one of the few studies in which PCDDs, PCDFs, and dioxin-like PCBs have been measured in the blood of pregnant women. Of the 195 pregnant women, 101 were primipara (mean: 28.8 years) and 94 were multipara (mean: 32.4 years). The arithmetic mean total TEQ concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs of primiparous and multiparous mothers in Sapporo City were 17.4 (median: 15.7) and 14.0 (median: 13.9)pgTEQ/glipid, respectively, and the concentrations were in the range of 6.6-43.4 and 3.4-28.2pgTEQ/glipid, respectively. In regard to the relationship between the total TEQ concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs in maternal blood and the number of deliveries or age of primiparous and multiparius mothers, the levels of these dioxin-like compounds tended to decrease with increases in the number of deliveries and significantly increased with increasing maternal age in both groups. Furthermore, significant correlations were observed between the total TEQ concentrations of these dioxin-like compounds and the age of primiparae and multiparae. The total TEQ concentration of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs measured in 195 pregnant women has decreased compared to past levels in Japan for the last several decades. The results of the present study have indicated that dioxin contamination in the blood of young women in Japan is continuing to decrease.
authors.affiliation: Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. todaka@fihes.pref.fukuoka.jp <todaka@fihes.pref.fukuoka.jp>
authors.forename: Takashi
authors.initials: T
authors.lastname: Todaka
authors.forename: Hironori
authors.initials: H
authors.lastname: Hirakawa
authors.forename: Jumboku
authors.initials: J
authors.lastname: Kajiwara
authors.forename: Tsuguhide
authors.initials: T
authors.lastname: Hori
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tobiishi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Onozuka
authors.forename: Shizue
authors.initials: S
authors.lastname: Kato
authors.forename: Seiko
authors.initials: S
authors.lastname: Sasaki
authors.forename: Sonomi
authors.initials: S
authors.lastname: Nakajima
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Saijo
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Sata
authors.forename: Reiko
authors.initials: R
authors.lastname: Kishi
authors.forename: Takao
authors.initials: T
authors.lastname: Iida
authors.forename: Masutaka
authors.initials: M
authors.lastname: Furue
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001572:Benzofurans / Q000097:blood*; D000072338:Dibenzofurans, Polychlorinated; D005260:Female; D006801:Humans; D007564:Japan; D008423:Maternal Age; D018811:Maternal Exposure; D008875:Middle Aged; D010298:Parity; D011078:Polychlorinated Biphenyls / Q000097:blood*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000097:blood; D011247:Pregnancy
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls