title: Self-assembled virus-like particles with magnetic cores.
abstract: Efficient encapsulation of functionalized spherical nanoparticles by viral protein cages was found to occur even if the nanoparticle is larger than the inner cavity of the native capsid. This result raises the intriguing possibility of reprogramming the self-assembly of viral structural proteins. The iron oxide nanotemplates used in this work are superparamagnetic, with a blocking temperature of about 250 K, making these virus-like particles interesting for applications such as magnetic resonance imaging and biomagnetic materials. Another novel feature of the virus-like particle assembly described in this work is the use of an anionic lipid micelle coat instead of a molecular layer covalently bound to the inorganic nanotemplate. Differences between the two functionalization strategies are discussed.
authors.affiliation: Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, USA.
authors.forename: Xinlei
authors.initials: X
authors.lastname: Huang
authors.forename: Lyudmila M
authors.initials: LM
authors.lastname: Bronstein
authors.forename: John
authors.initials: J
authors.lastname: Retrum
authors.forename: Chris
authors.initials: C
authors.lastname: Dufort
authors.forename: Irina
authors.initials: I
authors.lastname: Tsvetkova
authors.forename: Stella
authors.initials: S
authors.lastname: Aniagyei
authors.forename: Barry
authors.initials: B
authors.lastname: Stein
authors.forename: Galen
authors.initials: G
authors.lastname: Stucky
authors.forename: Brandon
authors.initials: B
authors.lastname: McKenna
authors.forename: Nicholas
authors.initials: N
authors.lastname: Remmes
authors.forename: David
authors.initials: D
authors.lastname: Baxter
authors.forename: C Cheng
authors.initials: CC
authors.lastname: Kao
authors.forename: Bogdan
authors.initials: B
authors.lastname: Dragnea
mesh_terms: D003460:Crystallization / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008280:Magnetics; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D013499:Surface Properties; D014771:Virion / Q000737:chemistry* / Q000648:ultrastructure*
chemical_list: D005290:Ferric Compounds; D046911:Macromolecular Substances; C000499:ferric oxide