[Role of IgE-dependent reactions in atopic dermatitis].
Atopic dermatitis is a disease of multifactorial pathogenesis.


OBJECTIVE
of the study was to establish the most common allergens responsible for development of atopic symptoms in children with atopic dermatitis.


METHODS
the study complied 36 children aged 4 months - 3 years treated in the Department of Children Allergology, Gastroenterology and Nutrition because of atopic dermatitis. With each case the patient and family history of atopy was collected and basic laboratory tests were conducted (including total IgE and specific IgE using Polly Check system).


RESULTS
eosinophilia was found in 11/36 children, elevated total IgE level in 16/36 and specific IgE were present in 14/36 patients. 6 patients proved to have sIgE for more then one allergen. The most commonly found allergens were animal hair, and food allergens. In 22 cases in spite of obvious clinical symptoms requiring therapy at hospital, all sIgE were negative for all tested allergens.


CONCLUSIONS
although estimating sIgE is commonly used in diagnosing atopic dermatitis, it may not be sufficient to establish complete diagnosis. It seems that animal hair and food allergens are mainly responsible for development of atopic dermatitis.
Dynowski
Jarosław
J
Klinika Alergologii, Gastroenterologii i Zywienia Dzieci III Katedry Pediatrii UM, ul. Sporna 36/50, 91-738 Łodz, Poland.
Wasowska-Królikowska
Krystyna
K
Modzelewska-Hołyńska
Małgorzata
M
Tomaszewska
Monika
M
Funkowicz
Marzena
M
D000485:Allergens / Q000145:classification / Q000276:immunology; D000818:Animals; D002415:Cats; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D003937:Diagnosis, Differential; D004285:Dogs; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000276:immunology*; D006736:Horses; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis* / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D008297:Male; D011058:Pollen / Q000276:immunology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012882:Skin Tests / Q000379:methods
D000485:Allergens; D007073:Immunoglobulin E