Anthracycline-induced phospholipase A2 inhibition.
The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2 is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of the early culprits leading to anthracycline-induced cardiac dysfunction. The clinical importance and potential pharmaceutical use of this new phenomenon await further studies.
Swift
Luther
L
Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington, DC 20037, USA.
McHowat
Jane
J
Sarvazyan
Narine
N
D000818:Animals; D018943:Anthracyclines / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D004791:Enzyme Inhibitors; D006331:Heart Diseases / Q000139:chemically induced / Q000503:physiopathology; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D004791:Enzyme Inhibitors; D010743:Phospholipids; D004317:Doxorubicin; D010741:Phospholipases A; D054467:Phospholipases A2