Gamma-herpesviruses and cellular signaling in AIDS-associated malignancies.
gamma-Herpesviruses, Epstein-Barr virus (EBV/HHV-4) and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), are involved in human carcinogenesis, particularly in immunocompromised patients. Virus-associated malignancies are becoming of significant concern for the mortality of long-lived immunocompromised patients, and therefore, research of advanced strategies for AIDS-related malignancies is an important field in cancer chemotherapy. Detailed understanding of the EBV and KSHV lifecycle and related cancers at the molecular level is required for novel strategies of molecular-targeted cancer chemotherapy. The present review gives a simple outline of the functional interactions between KSHV- and EBV-viral gene products and host cell deregulated signaling pathways as possible targets of chemotherapy against AIDS-related malignancies.
Noguchi
Kohji
K
Department of Bioactive Molecules, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Fukazawa
Hidesuke
H
Murakami
Yuko
Y
Takahashi
Naoko
N
Yamagoe
Satoshi
S
Uehara
Yoshimasa
Y
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D012514:Sarcoma, Kaposi / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*