beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice.
beta-Lactotensin (His-Ile-Arg-Leu) is an ileum-contracting tetrapeptide isolated from bovine beta-lactoglobulin. We previously reported that a neurotensin agonist beta-lactotensin shows antinociceptive effect through neurotensin NT(2) receptor. We found that centrally or orally administered beta-lactotensin at a dose of 60nmol/mouse or 300-500mg/kg, respectively, increased memory consolidation in the step-through-type inhibitory avoidance test in mice. The memory-enhancing activity of beta-lactotensin was inhibited by the dopamine D(2) receptor antagonist raclopride but not the D(1) receptor antagonist SCH23390. Taken together, beta-lactotensin might improve memory consolidation through activating the dopamine D(2) receptor.
Ohinata
Kousaku
K
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto 611-0011, Japan.
Sonoda
Soushi
S
Inoue
Natsumi
N
Yamauchi
Rena
R
Wada
Keiji
K
Yoshikawa
Masaaki
M
D000818:Animals; D002417:Cattle; D007782:Lactoglobulins / Q000737:chemistry; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D017448:Receptors, Dopamine D2 / Q000378:metabolism
D007782:Lactoglobulins; D009842:Oligopeptides; D017448:Receptors, Dopamine D2; C102984:beta-lactotensin