[Hantavirus cardiopulmonary syndrome in the Triângulo Mineiro and Alto Paranaíba regions, State of Minas Gerais, 1998-2005: clinical-epidemiological aspects of 23 cases].
The epidemiological, clinical, laboratory and treatment findings from 23 cases of hantavirus cardiopulmonary syndrome were analyzed. These cases were identified either serologically or immunohistochemically in hospitals in the municipality of Uberlândia, State of Minas Gerais. Fever (100%), dyspnea (100%) and myalgia (78%) were the symptoms most frequently observed in this sample. The most prevalent physical signs were hypotension (65%) and tachycardia (65%). The most common laboratory findings included thrombocytopenia (96%), hemoconcentration (83%) and leukocytosis (74%). Abnormal values for liver enzymes were found in all the patients tested and abnormalities in chest radiography were very frequent (95.6%). In 55.5% of the patients, orotracheal intubation and hemodynamic support were required. The present study confirmed the seasonal pattern of hantavirus cardiopulmonary syndrome in the Uberlândia region and the involvement of professional groups who are considered to be at low risk of infection, in the transmission cycle of the disease. The high lethality rate (39%) and the severity of the disease observed in this study may be related to attending to these patients at a late stage.
Limongi
Jean Ezequiel
JE
Centro de Controle de Zoonoses, Secretaria Municipal de Saúde de Uberlândia, Uberlândia, MG.
da Costa
Fabíola Corrêa
FC
de Paula
Márcia Beatriz Cardoso
MB
Pinto
Rogério de Melo Costa
Rde M
Oliveira
Maria de Lourdes Aguiar
Mde L
Pajuaba Neto
Adalberto de Albuquerque
Ade A
Borges
Aércio Sebastião
AS
Ferreira
Marcelo Simão
MS
D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D005260:Female; D006476:Orthohantavirus / Q000276:immunology* / Q000302:isolation & purification; D018804:Hantavirus Pulmonary Syndrome / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012377:Rodentia; D012621:Seasons; D012720:Severity of Illness Index
D000914:Antibodies, Viral; D007075:Immunoglobulin M