[Using leucine and zinc sulfate for the correction of metabolic disturbances induced by paracetamol].
A mixture of leucine and zinc sulfate (4 : 1; 100 mg/kg body weight) produces a hepatoprotective effect, preventing the ultrastructural injury of hepatic tissue and the disturbance of free amino acid metabolism caused by a toxic dose of paracetamol.
Sheĭbak
V M
VM
Smirnova
V Iu
VIu
Goretskaia
M V
MV
Kravchuk
R I
RI
D000082:Acetaminophen / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000596:Amino Acids / Q000097:blood; D018712:Analgesics, Non-Narcotic / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000818:Animals; D019610:Cytoprotection; D004338:Drug Combinations; D005260:Female; D007930:Leucine / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D019287:Zinc Sulfate / Q000494:pharmacology*
D000596:Amino Acids; D018712:Analgesics, Non-Narcotic; D004338:Drug Combinations; D000082:Acetaminophen; D019287:Zinc Sulfate; D007930:Leucine