Biokinetics and dose estimation of 65Zn in the salivary gland and male reproductive organs.
ICRP is revising its recommendations for radiological protection and has added salivary and secretory glands as new target organs. However, little information is available on the distributions of radionuclides in the salivary gland, secretory glands and male reproductive organs. This study deals with the distribution of 65Zn in the salivary gland and male reproductive organs as a function of time after a single intravenous and oral administration. For the study, 64 Wistar strain male rats, eight weeks of age were used. The rats were periodically sacrificed, the liver, kidney, spleen, pancreas, thymus, salivary gland, testis, epididymitis and prostate gland sampled and the radioactivity of these organs measured with an NaI scintillation counter. The relative concentration of 65Zn was highest in the prostate gland. We estimated the radiation dose in humans using rat data for the salivary and secretory glands as well as reproductive organs after intake of 65Zn.
Matsumoto
M
M
Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba-shi 263-8555, Japan.
Homma-Takeda
S
S
Nishimura
Y
Y
D000284:Administration, Oral; D000818:Animals; D001681:Biological Assay / Q000379:methods*; D003198:Computer Simulation; D005837:Genitalia, Male / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D012062:Relative Biological Effectiveness; D012469:Salivary Glands / Q000378:metabolism*; D012680:Sensitivity and Specificity; D013045:Species Specificity; D014018:Tissue Distribution; D015037:Zinc Radioisotopes / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D015037:Zinc Radioisotopes