title: Effect of mild hypothermia on glucose metabolism and glycerol of brain tissue in patients with severe traumatic brain injury.
abstract: OBJECTIVE
  To study the effect of mild hypothermia on glucose metabolism and glycerol of brain tissue in patients with severe traumatic brain injury (STBI) using clinical microdialysis.
  
  
  METHODS
  Thirty-one patients with STBI(GCS less than or equal to 8) were randomly divided into hypothermic group(Group A) and control group(Group B). Microdialysis catheters were inserted into the cerebral cortex of perilesional and normal brain tissue. All samples were analyzed using CMA microdialysis analyzer.
  
  
  RESULTS
  In comparison with the control group, lactate/glucose ratio(L/G), lactate/pyruvate ratio(L/P) and glycerol(Gly) in perilensional tissue were significantly decreased; L/P in normal brain tissue was significantly decreased. In control group, L/G, L/P and Gly in perilensional tissue were higher than that in normal brain tissue. In the hypothermic group, L/P in perilensional tissue was higher than that in relative normal brain.
  
  
  CONCLUSIONS
  Mild hypothermia protects brain tissues by decreasing L/G, L/P and Gly in perilensional tissue and L/P in "normal brain" tissues. The energy crisis and membrane phospholipid degradation in perilensional tissue are easier to happen after traumatic brain injury, and mild hypothermia protects brain better in perilensional tissue than in normal brain tissue.
authors.affiliation: Department of Neurosurgery, Huanhu Hospital, Tianjin 300060, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.forename: Ai-lin
authors.initials: AL
authors.lastname: Li
authors.forename: Da-shi
authors.initials: DS
authors.lastname: Zhi
authors.forename: Hui-ling
authors.initials: HL
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism; D001930:Brain Injuries / Q000378:metabolism* / Q000628:therapy*; D005947:Glucose / Q000378:metabolism*; D005990:Glycerol / Q000032:analysis*; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D017551:Microdialysis; D008875:Middle Aged
chemical_list: D005947:Glucose; D005990:Glycerol