Changes of human B and B-1a peripheral blood lymphocytes with age.
In 2057 consecutive subjects admitted to the Department of Pathology, Section of Immunology of the Verona University Hospital, CD19+ and CD5/CD19 double positive cells were determined to assess the behaviour of total peripheral B-lymphocytes and B-1a (CD5+) compartments in humans during aging. We show that the absolute number of total B lymphocytes increases about three-fold from the baseline conditions in the first year of life and progressively decreases until adult age. A slower decrease was detected from the adult age onwards. A similar behaviour has been observed within the B-1a subset of B-lymphocytes, although the decrease after the adult age seems more pronounced. Possible physiological explanations and/or implications for the disease states are taken into account.
Veneri
Dino
D
Section of Hematology, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy. dino.veneri@univr.it
Franchini
Massimo
M
Vella
Antonio
A
Tridente
Giuseppe
G
Semenzato
Gianpietro
G
Pizzolo
Giovanni
G
Ortolani
Riccardo
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D018941:Antigens, CD19 / Q000032:analysis; D016175:B-Lymphocyte Subsets / Q000166:cytology*; D018956:CD5 Antigens / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged
D018941:Antigens, CD19; D018956:CD5 Antigens