title: Acute role of the brain-derived neurotrophic factor (BDNF) on the respiratory neural network activity in mice in vitro.
abstract: In humans, several pathologies are associated with disturbances of the respiratory control, some of them including alteration in the brain-derived neurotrophic factor (BDNF) signalling pathway. BDNF has long been known as a neurotrophic factor involved in survival, differentiation and maintenance of neuronal populations in the peripheral and central nervous system. More recently BDNF has also been discovered to be a potent neuromodulator with acute effects on neuronal excitability and synaptic plasticity. Animals deleted for the gene encoding BDNF exhibit respiratory alteration suggesting an important but yet undefined role of the neurotrophin in respiratory rhythmogenesis either by a trophic and/or an acute action. The possibility that BDNF might exert an acute regulatory role on the rhythmic activity of the respiratory generator of the pre-Bötzinger complex has been recently examined in newborn mice in vitro. Results obtained, reviewed in the present paper, will help getting insights in respiratory rhythm regulatory mechanisms that involve BDNF signalling.
authors.affiliation: Laboratoire de Neurobiologie Génétique et Intégrative Institut Alfred Fessard, CNRS UPR2216, 1 avenue de la terrasse, 91198 Gif sur Yvette, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Bouvier
authors.forename: Sandra
authors.initials: S
authors.lastname: Autran
authors.forename: Gilles
authors.initials: G
authors.lastname: Fortin
authors.forename: Jean
authors.initials: J
authors.lastname: Champagnat
authors.forename: Muriel
authors.initials: M
authors.lastname: Thoby-Brisson
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010507:Periodicity; D012125:Respiratory Center / Q000033:anatomy & histology / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor