Congenital cytomegalovirus infection: a cause of renal dysplasia?
Cytomegalovirus (CMV) infection is one of the most frequently encountered viral infections of the fetus and induces a wide range of histologic and clinical manifestations. Congenital abnormalities are typically restricted to the central nervous system despite evidence of CMV inclusions occurring in most epithelial cells. Although tissue injury and even glomerulonephritis have been observed in congenital CMV infections, renal multicystic dysplasia has not been reported. Herein, we describe a case of unilateral renal dysplasia in a 19-week fetus with concurrent CMV infection. We believe the present case to be the first description of a virus apparently inducing renal multicystic dysplasia.
Chan
Maren
M
Department of Pathology at Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. mmchan@bidmc.harvard.edu
Hecht
Jonathan L
JL
Boyd
Theonia
T
Rosen
Seymour
S
D000025:Abortion, Eugenic; D000328:Adult; D002467:Cell Nucleus / Q000473:pathology / Q000821:virology; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000473:pathology* / Q000635:transmission; D005260:Female; D005315:Fetal Diseases / Q000473:pathology* / Q000821:virology; D005865:Gestational Age; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology / Q000821:virology; D007181:Inclusion Bodies, Viral / Q000473:pathology / Q000821:virology; D018445:Infectious Disease Transmission, Vertical; D007684:Kidney Tubules / Q000473:pathology / Q000821:virology; D021782:Multicystic Dysplastic Kidney / Q000473:pathology* / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious