title: Efficacy of ticlopidine for preventing migraine after transcatheter closure of atrial septal defect with Amplatzer septal occluder: a case report.
abstract: Transcatheter closure of an atrial septal defect using the Amplatzer septal occluder is a current treatment option in Japan, but is occasionally associated with transient exacerbation or new onset migraine. Clopidogrel is effective in such a situation, but the efficacy of ticlopidine, an analog of clopidogrel, on migraine remains unclear. A 15-year-old girl presented with typical migraine attacks with aura 11 days after transcatheter closure of an atrial septal defect with an Amplatzer septal occluder. All examinations excluded thromboembolic origin of the migrain. Her symptoms disappeared completely after medication with ticlopidine.
authors.affiliation: Department of Cardiology, Hokkaido Children's Hospital and Medical Center, Zenibako 1-10-1, Otaru, Hokkaido 047-0261. tomitah@sapmed.ac.jp
authors.forename: Hideshi
authors.initials: H
authors.lastname: Tomita
authors.forename: Kinya
authors.initials: K
authors.lastname: Hatakeyama
authors.forename: Wataru
authors.initials: W
authors.lastname: Soda
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kobayashi
mesh_terms: D000293:Adolescent; D006328:Cardiac Catheterization / Q000009:adverse effects*; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000601:surgery*; D006801:Humans; D020325:Migraine with Aura / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D013988:Ticlopidine / Q000627:therapeutic use*
chemical_list: D013988:Ticlopidine