title: The influence of hemodialysis on P-wave signal-averaged electrocardiogram findings.
abstract: The role of P-wave signal-averaged electrocardiography (P-SAECG) in the prediction of atrial fibrillation (AF) attacks has been validated in various disease states. In the present study, we aimed to investigate the effect of hemodialysis (HD) on P-SAECG parameters and to determine the related risk factors that might affect those parameters. Ninety-one HD patients and 68 controls were included. Hemoglobin levels, serum electrolytes, arterial pH, and interdialytic weight changes were assessed. P-wave duration (PWD) and late potentials of P wave (root-mean-square voltage for the last 20 ms of the signal-averaged P wave [LP20]) were determined by P-SAECG. Pre- and postdialysis PWDs were significantly increased in HD patients than in controls (both P < 0.05), while the voltages of pre- and postdialysis LP20 were significantly reduced (both P < 0.05). A significant increase in PWD (P < 0.05) and a significant decrease in LP20 (P < 0.05) were observed following HD. Pre- and postdialysis PWDs and LP20 were correlated with age (all P < 0.05), dialysis duration (all P < 0.05), and left atrial diameters (LADs) (pre- and postdialysis) (all P < 0.05). Intradialytic changes in serum potassium levels were only correlated with postdialysis PWD and LP20 in HD patients (both P < 0.05). HD seems to increase PWD and to reduce LP20. Advanced age, duration of HD, intradialytic change in serum potassium levels, and LAD seem to be the important associates of P-SAECG parameters in HD patients.
authors.affiliation: Department of Cardiology, Mersin University, Mersin, Turkey.
authors.forename: Turkay
authors.initials: T
authors.lastname: Ozcan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Horoz
authors.forename: Gultekin
authors.initials: G
authors.lastname: Genctoy
authors.forename: Bulent
authors.initials: B
authors.lastname: Uyar
authors.forename: Ahmet
authors.initials: A
authors.lastname: Camsari
authors.forename: Ahmet A
authors.initials: AA
authors.lastname: Kiykim
mesh_terms: D000328:Adult; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012815:Signal Processing, Computer-Assisted