Magnetic resonance imaging as a tool for monitoring stem cell migration.
Noninvasive monitoring of stem cells is an important step in developing stem-cell-based therapies. Among several imaging techniques available, magnetic resonance imaging (MRI) provides an effective way to detect implanted stem cells in live animals. In this mini-review, we discuss the available MRI contrast agents and different cell-labeling strategies used for detection of stem cell migration in the brain. The potential effects of MRI contrast agents on stem cell viability and differentiation are also discussed.
Magnitsky
S
S
Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Walton
R M
RM
Wolfe
J H
JH
Poptani
H
H
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008991:Monitoring, Physiologic; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*