title: Immune response to Haemonchus contortus infection in susceptible (INRA 401) and resistant (Barbados Black Belly) breeds of lambs.
abstract: The immune responses to Haemonchus contortus were compared in studies in resistant Barbados Black Belly (BBB) and susceptible INRA 401 (INRA) breeds of lambs. The cytokine patterns indicated a Th2-biased response in both breeds. A more persistent and elevated Th2 cytokine mRNA transcription and blood eosinophilia were noted in the BBB lambs. However, at days 4 and 30 post-infection, abomasal recruitment of eosinophils and mast cells were similar between the two breeds. Following primary infections, the BBB demonstrated a substantially lower faecal egg count compared to the INRA lambs. Furthermore, worm counts at 4 and 30 days post-infection, and adult female worm size and in utero egg counts 30 days after the first infection were significantly lower in the BBB than in the INRA breed. In the INRA breed, re-infection caused a significant reduction in most parasitological parameters compared with those observed after the primary infection. A similar response was not observed in the BBB sheep. In conclusion, while the major driving force in the response to H. contortus infection is a Th2-biased immunity in which the BBB showed its maximal performance during the primary infection, the INRA breed performed better after re-infection compared to its response to first exposure.
authors.affiliation: Addis Ababa University, Faculty of Veterinary Medicine, Debre-Zeit, Ethiopia.
authors.forename: G
authors.initials: G
authors.lastname: Terefe
authors.forename: C
authors.initials: C
authors.lastname: Lacroux
authors.forename: O
authors.initials: O
authors.lastname: Andreoletti
authors.forename: C
authors.initials: C
authors.lastname: Grisez
authors.forename: F
authors.initials: F
authors.lastname: Prevot
authors.forename: J P
authors.initials: JP
authors.lastname: Bergeaud
authors.forename: J
authors.initials: J
authors.lastname: Penicaud
authors.forename: V
authors.initials: V
authors.lastname: Rouillon
authors.forename: L
authors.initials: L
authors.lastname: Gruner
authors.forename: J C
authors.initials: JC
authors.lastname: Brunel
authors.forename: D
authors.initials: D
authors.lastname: Francois
authors.forename: J
authors.initials: J
authors.lastname: Bouix
authors.forename: P
authors.initials: P
authors.lastname: Dorchies
authors.forename: P
authors.initials: P
authors.lastname: Jacquiet
mesh_terms: D000818:Animals; D017849:Animals, Inbred Strains; D000909:Antibodies, Helminth / Q000097:blood; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D005243:Feces / Q000469:parasitology; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006188:Haemonchiasis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D006189:Haemonchus / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D010270:Parasite Egg Count; D020116:Pepsinogen A / Q000097:blood; D011897:Random Allocation; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000469:parasitology; D034561:Sheep, Domestic; D013047:Specific Pathogen-Free Organisms
chemical_list: D000909:Antibodies, Helminth; D016207:Cytokines; D007074:Immunoglobulin G; D020116:Pepsinogen A