[The preparation of series of the controllable degradation coral-hydroxyapatite (SCHA-200R) and the on its application as the scaffold in bone tissue-engineering].
OBJECTIVE
Fabricate series of the controllable degradation coral-hydroxyapatite.


METHODS
The natural coral undergo a chemical reaction with (NH4)2 HPO4 at high temperature and pressure for different time-lengths. After getting the products, the components and the special structures were analyzed. Observe the biologic degradation of the reaction products and analyze the metal elements and their contents. Haemolysis tests, cytotoxity tests and bone compatibility tests were performed to assess the biocompatibility of the products.


RESULTS
When hydrothermal reactions happened under different conditions, the different gradients of CaCO3/hydroxyapatite materials were produced. These types of materials kept the characteristic of interconnected micro-porous network structures. A thin layer of compact material can be seen on the surface of its trabecula ultra-micro structure. The SCHA-200R has a good biocompatibility.


CONCLUSIONS
Gradient HA (SCHA-200R) materials can be formed by adjusting the same temperature, same pressure and different time-length of the reaction. This kind of gradient material keeps the quality of micro-porous network structures. The SCHA-200R is a potential candidate scaffold for bone tissue engineering.
Gao
Zhan
Z
Qindu Stomatological College, Forth Military Medical University, Xi'an 710032, China.
Mao
Tian-Qiu
TQ
Chen
Fu-Lin
FL
He
Li-Sheng
LS
Hou
Rui
R
Yang
Yao-Wu
YW
Wu
Xiao-Jing
XJ
D020341:Absorbable Implants; D000818:Animals; D037421:Anthozoa / Q000737:chemistry; D018786:Bone Substitutes; D017886:Durapatite / Q000138:chemical synthesis*; D008297:Male; D008422:Materials Testing; D011817:Rabbits; D023822:Tissue Engineering / Q000379:methods*
D018786:Bone Substitutes; D017886:Durapatite