WITHDRAWN: Follicle-stimulating hormone and human menopausal gonadotropin for ovarian stimulation in assisted reproduction cycles.
BACKGROUND
Both human menopausal gonadotropin (hMG) and human follicle stimulating hormone (hFSH) have been used successfully for ovarian stimulation, but the relative importance of FSH and luteinizing hormone (LH) in follicular growth and maturation has been the subject of much debate.


OBJECTIVE
To conduct a systematic overview of available data comparing FSH and hMG in IVF treatment cycles.


METHODS
This review has drawn on the search strategy developed for the Menstrual Disorders & Subfertility Group as a whole. Relevant trials were identified in the Group's Specialised Register of Controlled Trials. See Review Group details for more information.


METHODS
Randomised controlled trials or quasi randomised controlled trials of ovarian stimulation with either hFSH or hMG, in combination with GnRHa or alone, in IVF treatment cycles.


METHODS
Common odds ratios (OR) were calculated after demonstrating homogeneity of treatment effect across all trials.


RESULTS



METHODS
Clinical pregnancy rates per cycle started, per cycle reaching oocyte retrieval, and per cycle reaching embryo transfer (ET).


RESULTS
Eight trials met the inclusion criteria. The overall OR in favour of FSH for cycle start, oocyte retrieval, and ET were 1.70 (95% CI, 1.11-2.60), 1.68 (95% CI, 1.10-2.56), and 1.69 (95% CI, 1.10-2.59), respectively.


CONCLUSIONS
This meta-analysis demonstrates that in IVF cycles the use of FSH is associated with a significantly higher clinical pregnancy rate than hMG.
Daya
S
S
McMaster University, Department of Obstetrics & Gynecology, Clinical Epidemiology & Biostatistics, HSC-3N52, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5. dayas@mcmaster.ca
D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use*; D010062:Ovulation Induction; D011247:Pregnancy
D008596:Menotropins; D005640:Follicle Stimulating Hormone