title: TiCl4-catalyzed indirect anti-Markovnikov hydration of alkynes: application to the synthesis of benzo[b]furans.
abstract: An efficient methodology for the indirect anti-Markovnikov hydration of unsymmetrically substituted terminal and internal alkynes is based on TiCl4-catalyzed hydroamination reactions. Its application to ortho-alkynylhaloarenes, followed by a copper-catalyzed O-arylation, provides flexible access to substituted benzo[b]furans.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universitaet Goettingen, Tammannstrasse 2, D-37077 Goettingen, Germany. Lutz.Ackermann@chemie.uni-goettingen.de
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann
authors.forename: Ludwig T
authors.initials: LT
authors.lastname: Kaspar