title: Decreased circulating protective adiponectin level is associated with angiographic coronary disease progression in patients with angina pectoris.
abstract: Adipocyte cytokines regulate glucose metabolism and insulin resistance and adiponectin is thought to have a protective effect against atherosclerosis. Studies have shown that adiponectin expression is decreased in obese subjects and those with metabolic syndrome or diabetes mellitus. The purpose of this study was to investigate the relationship between circulating adipocyte cytokine concentrations and angiographic coronary artery disease (CAD) progression in patients with chest pain. Patients with stable angina pectoris who underwent repeat coronary angiograms and had serum samples at the time of first catheterization between March 1999 and January 2004 were enrolled. A modified Gensini scoring system was used to define angiographic coronary artery progression between the index and follow-up angiograms. Those who had significant angiographic progression of coronary lesions were classified into the progression group (N=55). Those who did not have CAD progression were classified into the non-progression group (N=102). Univariate analysis showed that CAD progression was associated with male gender (93% vs. 78%, p=0.038), higher baseline total cholesterol (187+/-43 vs. 173+/-39 mg/dl, p=0.037) and higher baseline fasting blood glucose (128+/-57 vs. 110+/-40 mg/dl, p=0.037). Patients in the progression group had a significantly lower serum adiponectin level (14.3+/-7.9 vs. 18.9+/-13.2 mug/ml, p=0.007) than, but resistin (28.9+/-13.4 vs. 34.4+/-26.0 ng/ml, p=0.142) and leptin (7.4+/-4.6 vs. 7.7+/-6.5 ng/ml, p=0.675) levels similar to, those in the non-progression group. In a multivariate binary logistic regression model, male gender (odds ratio 4.283, p=0.015), higher serum cholesterol (odds ratio 1.010, p=0.032) and lower serum adiponectin (odds ratio 0.959, p=0.030) were all significant independent predictors of CAD progression. In conclusion, we found that a decreased circulating level of adiponectin is associated with angiographic CAD progression in patients with angina pectoris.
authors.affiliation: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Kae-Woei
authors.initials: KW
authors.lastname: Liang
authors.forename: Wayne Huey-Herng
authors.initials: WH
authors.lastname: Sheu
authors.forename: Wen-Lieng
authors.initials: WL
authors.lastname: Lee
authors.forename: Tsun-Jui
authors.initials: TJ
authors.lastname: Liu
authors.forename: Chih-Tai
authors.initials: CT
authors.lastname: Ting
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Hsieh
authors.forename: Kuo-Yang
authors.initials: KY
authors.lastname: Wang
authors.forename: Ying-Tsung
authors.initials: YT
authors.lastname: Chen
authors.forename: Wen-Jane
authors.initials: WJ
authors.lastname: Lee
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000000981:diagnostic imaging* / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography / Q000639:trends; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging* / Q000517:prevention & control; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D052242:Adiponectin; D015415:Biomarkers