Histoplasma capsulatum fungemia in patients with acquired immunodeficiency syndrome: detection by lysis-centrifugation blood-culturing technique.
Progressive disseminated histoplasmosis (PDH) is an increasingly common cause of infection in patients with acquired immune deficiency syndrome (AIDS). We report 21 cases of PDH associated with AIDS diagnosed by lysis-centrifugation blood culture method. The most prevalent clinical findings were fever, weight loss, respiratory symptoms, and mucocutaneous lesions. Chest roentgenogram showed diffuse pulmonary infiltrates in 13 of 21 patients (62%). Bronchoalveolar fluid has yielded positive culture in four patients only in medium with cycloheximide.
Oliveira
Flávio de Mattos
Fde M
PPG - Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Brazil.
Fernandes
Sérgio Sônego
SS
Severo
Cecília Bittencourt
CB
Guazzelli
Luciana Silva
LS
Severo
Luiz Carlos
LC
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000382:microbiology; D000328:Adult; D002498:Centrifugation / Q000379:methods; D046508:Culture Techniques; D005260:Female; D016469:Fungemia / Q000175:diagnosis* / Q000382:microbiology; D006658:Histoplasma / Q000145:classification / Q000302:isolation & purification; D006660:Histoplasmosis / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D008297:Male