title: Distribution and clinical significance of human papillomavirus subtypes in Shenzhen city, People's Republic of China.
abstract: This study investigated the subtype distribution of the human papillomavirus (HPV) in the patients with condyloma accuminatum (CA) in Shenzhen city, China, and assessed the relationship between different HPV subtypes and cervical neoplasia. Type-specific prevalence and extent of multiple infections were assessed in the genital tract. CA samples collected from the 352 patients in the departments of dermatology and gynecology from the People's Hospital in Shenzhen during 2004-2006, using MY09/11 PCR and reverse dot blot hybridization for genotyping of 9-20 kinds of HPV subtypes. HPV status was studied in relation to the pathologic findings. HPV type diversity was wide. The low-risk HPV subtype 11 and 6 were the main subtypes, and multiple HPV infection rate was about 37% in HPV-positive samples. High-risk HPV (HR-HPV) types (16, 18, 58, 52, and 33) were the main subtypes in the CA of cervix, especially in the advanced stage cervical intraepithelial neoplasia (cervical intraepithelial neoplasia II(+) or above), multiple HR-HPV infection was found in 87% of HPV-positive samples. We conclude that HPV type 6 and 11 were the main subtypes in patients with CA in Shenzhen region, while HPV type 16 and 18 may be one of the main reasons for malignant changes of cervix, but this study cannot prove the association between multiple HPV infection and severity of cervix lesions.
authors.affiliation: The Second Clinical Medical College, Jinan University, Shenzhen People's Hospital, Guangdong Province, China. xiaoyong62@tom.com
authors.forename: Y
authors.initials: Y
authors.lastname: Dai
authors.forename: Y S
authors.initials: YS
authors.lastname: Huang
authors.forename: M
authors.initials: M
authors.lastname: Tang
authors.forename: X P
authors.initials: XP
authors.lastname: Lv
authors.forename: T Y
authors.initials: TY
authors.lastname: Li
authors.forename: Y B
authors.initials: YB
authors.lastname: Yin
mesh_terms: D000328:Adult; D052685:Alphapapillomavirus / Q000145:classification* / Q000302:isolation & purification*; D002681:China; D003218:Condylomata Acuminata / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000821:virology*