title: Decennial follow-up in patients with recurrent tachycardia originating from the right ventricular outflow tract: electrophysiologic characteristics and response to treatment.
abstract: OBJECTIVE
  In the setting of right ventricular outflow tract-tachycardia (RVOT-T), data about long-term follow-up (FU) with respect to the therapeutic strategies are missing. All patients (pts) referred to our institution during the last 20 years for the treatment of RVOT-T were studied in a retrospective analysis to assess mortality and efficacy of treatment.
  
  
  RESULTS
  One hundred and thirty-three patients (77 female; 39+/-13 years) with sustained RVOT-T were included in this study. At the time of first presentation, diagnosis of RVOT-T was made by complete invasive and non-invasive diagnostic assessment, including electrophysiology study and two-dimensional echocardiography. After 135+/-68 months (median 136, range 29-248), patients were invited to undergo clinical assessment. Of the 133 pts, 127 (95%) survived and six (5%) died from non-cardiac disease. Anti-arrhythmic (AA) drugs were given to 62 of the 133 pts (47%); of them 32 (52%) had recurrences during follow-up. The mean time to recurrence was 10.02 years (95% CI 7.46-12.59). The other 71 study patients (53%) underwent catheter ablation. The procedure was successful in 58 pts (82%). During follow-up, 30 (52%) of the 58 successfully treated patients had recurrences of RVOT-T. The mean time to recurrence was 6.28 years (95% CI 4.96-7.6). RVOT-T recurrences were similar in morphology to those treated previously in 33% and different in 67% of cases.
  
  
  CONCLUSIONS
  Long-term follow-up in patients with RVOT-T is favourable. Catheter ablation is effective in this setting. However, late recurrences with similar or different morphology may arise in half of the patients after initially successful treatment. AA drug therapy is a valid initial therapeutic option, since it is effective in about half of the patients.
authors.affiliation: Department of Cardiology, University Heart Center, Martinistrasse 52, 20246 Hamburg, and Asklepios Hospital, Germany. ventura@uke.uni-hamburg.de
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Ventura
authors.forename: Daniel
authors.initials: D
authors.lastname: Steven
authors.forename: Hanno U
authors.initials: HU
authors.lastname: Klemm
authors.forename: Boris
authors.initials: B
authors.lastname: Lutomsky
authors.forename: Kai
authors.initials: K
authors.lastname: Müllerleile
authors.forename: Thomas
authors.initials: T
authors.lastname: Rostock
authors.forename: Helge
authors.initials: H
authors.lastname: Servatius
authors.forename: Tim
authors.initials: T
authors.lastname: Risius
authors.forename: Thomas
authors.initials: T
authors.lastname: Meinertz
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Kuck
authors.forename: Stephan
authors.initials: S
authors.lastname: Willems
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D054849:Cardiac Electrophysiology; D017115:Catheter Ablation; D017023:Coronary Angiography; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D017180:Tachycardia, Ventricular / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents