TB or not TB: calcium regulation in mycobacterial survival.
Mycobacterium tuberculosis (Mtb)-the bacterium that causes tuberculosis-resides in phagosomes inside macrophages. This bacterium evades destruction by preventing phagosome maturation, which involves the fusion of phagosomes with lysosomes. In this issue of Cell, Jayachandran et al. (2007) suggest that mycobacteria co-opt the actin-binding protein coronin 1 to activate the phosphatase calcineurin, thereby preventing phagosomal maturation.
Trimble
William S
WS
Program in Cell Biology, Hospital for Sick Children, Department of Biochemistry, University of Toronto, Toronto, Canada M5G 1X8.
Grinstein
Sergio
S
D000818:Animals; D019703:Calcineurin / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000378:metabolism* / Q000382:microbiology; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000378:metabolism* / Q000472:pathogenicity; D010588:Phagosomes / Q000378:metabolism / Q000382:microbiology; D014376:Tuberculosis
D008840:Microfilament Proteins; C072061:coronin proteins; D019703:Calcineurin; D002118:Calcium