title: Outcome in children with brain tumours diagnosed in the first year of life: long-term complications and quality of life.
abstract: OBJECTIVE
  To study the outcome in children with brain tumours diagnosed in the first year of life, we followed up 27 consecutive children who were diagnosed between 1980 and 2005 in a single institution.
  
  
  METHODS
  Tumour control and neurological, endocrine and cognitive complications and their impact on behavioural and emotional adjustment and health-related quality of life (HRQoL) were comprehensively assessed in 11 survivors (mean follow-up time 12.3 years).
  
  
  RESULTS
  Persistent neurological complications occurred in 9/11 patients, endocrine and growth complications in 4/11, and cognitive deficits leading to school problems/impaired choice of occupation in 8/10. Behavioural and psychological adjustment problems were reported by 4/6 patients and 7/10 parents. HRQoL as rated by patients and their parents was considerably lower than that of healthy controls. In comparison with healthy controls, social functioning was rated by the patients and the parents as the QoL dimension most affected. HRQoL was lowest for patients with high-grade tumour histology and more intense therapy.
  
  
  CONCLUSIONS
  Long-term survivors of brain tumours diagnosed in the first year of life are not only at great risk of neurological and cognitive complications, but also of social isolation thereby substantially decreasing self-rated HRQoL.
authors.affiliation: University Children's Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.
authors.forename: N U
authors.initials: NU
authors.lastname: Gerber
authors.forename: D
authors.initials: D
authors.lastname: Zehnder
authors.forename: T J
authors.initials: TJ
authors.lastname: Zuzak
authors.forename: A
authors.initials: A
authors.lastname: Poretti
authors.forename: E
authors.initials: E
authors.lastname: Boltshauser
authors.forename: M A
authors.initials: MA
authors.lastname: Grotzer
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications* / Q000523:psychology / Q000628:therapy; D002648:Child; D002653:Child Behavior Disorders / Q000209:etiology; D002675:Child, Preschool; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000209:etiology; D006305:Health Status Indicators; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology; D007223:Infant; D007231:Infant, Newborn; D007859:Learning Disabilities / Q000209:etiology; D009422:Nervous System Diseases / Q000209:etiology; D011594:Psychometrics; D011788:Quality of Life