title: [Hantavirus cardiopulmonary syndrome in the Triângulo Mineiro and Alto Paranaíba regions, State of Minas Gerais, 1998-2005: clinical-epidemiological aspects of 23 cases].
abstract: The epidemiological, clinical, laboratory and treatment findings from 23 cases of hantavirus cardiopulmonary syndrome were analyzed. These cases were identified either serologically or immunohistochemically in hospitals in the municipality of Uberlândia, State of Minas Gerais. Fever (100%), dyspnea (100%) and myalgia (78%) were the symptoms most frequently observed in this sample. The most prevalent physical signs were hypotension (65%) and tachycardia (65%). The most common laboratory findings included thrombocytopenia (96%), hemoconcentration (83%) and leukocytosis (74%). Abnormal values for liver enzymes were found in all the patients tested and abnormalities in chest radiography were very frequent (95.6%). In 55.5% of the patients, orotracheal intubation and hemodynamic support were required. The present study confirmed the seasonal pattern of hantavirus cardiopulmonary syndrome in the Uberlândia region and the involvement of professional groups who are considered to be at low risk of infection, in the transmission cycle of the disease. The high lethality rate (39%) and the severity of the disease observed in this study may be related to attending to these patients at a late stage.
authors.affiliation: Centro de Controle de Zoonoses, Secretaria Municipal de Saúde de Uberlândia, Uberlândia, MG.
authors.forename: Jean Ezequiel
authors.initials: JE
authors.lastname: Limongi
authors.forename: Fabíola Corrêa
authors.initials: FC
authors.lastname: da Costa
authors.forename: Márcia Beatriz Cardoso
authors.initials: MB
authors.lastname: de Paula
authors.forename: Rogério de Melo Costa
authors.initials: Rde M
authors.lastname: Pinto
authors.forename: Maria de Lourdes Aguiar
authors.initials: Mde L
authors.lastname: Oliveira
authors.forename: Adalberto de Albuquerque
authors.initials: Ade A
authors.lastname: Pajuaba Neto
authors.forename: Aércio Sebastião
authors.initials: AS
authors.lastname: Borges
authors.forename: Marcelo Simão
authors.initials: MS
authors.lastname: Ferreira
mesh_terms: D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D005260:Female; D006476:Orthohantavirus / Q000276:immunology* / Q000302:isolation & purification; D018804:Hantavirus Pulmonary Syndrome / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012377:Rodentia; D012621:Seasons; D012720:Severity of Illness Index
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M