title: Local anesthetics: significance of hydrogen bonding in mechanism of action.
abstract: The action of local anesthetics is considered in terms of their ability to function as the donor in a hydrogen bond. The formation of a hydrogen-bonded complex between the drug and an acceptor group on the neural membrane is suggested as a feature in the action of local anesthetics.
authors.affiliation: Biocrystallography Laboratory, Veterans Administration Hospital, Pittsburgh, Pennsylvania 15240, USA.
authors.forename: M
authors.initials: M
authors.lastname: Sax
authors.forename: J
authors.initials: J
authors.lastname: Pletcher
mesh_terms: D000779:Anesthetics, Local / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D003460:Crystallization; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008956:Models, Chemical; D010743:Phospholipids / Q000737:chemistry* / Q000378:metabolism; D011343:Procaine / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D010743:Phospholipids; D011343:Procaine