Reference-independent ERP old/new effects of auditory and visual word recognition memory: Joint extraction of stimulus- and response-locked neuronal generator patterns.
To clarify polarity, topography, and time course of recognition memory ERP old/new effects during matched visual and auditory continuous word recognition tasks, unrestricted temporal PCA jointly analyzed stimulus- and response-locked, reference-free current source densities (31-channel, N=40). Randomization tests provided unbiased statistics for complete factor topographies. Old/new left parietal source effects were complemented by lateral frontocentral sink effects in both modalities, overlapping modality-specific P3 sources 160 ms preresponse. A mid-frontal sink 45 ms postresponse terminated the frontoparietal generator pattern, showed old/new effects consistent with bilateral activation of anterior cingulate and SMA, and preceded similar activity extending posteriorly along the longitudinal fissure. These methods separated old/new stimulus source (preresponse) and response sink (postresponse) effects from motor and modality-specific ERPs.
Kayser
Jürgen
J
Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA. kayserj@pi.cpmc.columbia.edu
Tenke
Craig E
CE
Gates
Nathan A
NA
Bruder
Gerard E
GE
D000328:Adult; D000465:Algorithms; D003627:Data Interpretation, Statistical; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D025341:Principal Component Analysis; D021641:Recognition, Psychology / Q000502:physiology*