title: Dendritic cell neoplasms: an overview.
abstract: Dendritic cell neoplasms are rare tumors that are being recognized with increasing frequency. They were previously classified as lymphomas, sarcomas, or histiocytic neoplasms. The World Health Organization (WHO) classifies dendritic cell neoplasms into five groups: Langerhans' cell histiocytosis, Langerhans' cell sarcoma, Interdigitating dendritic cell sarcoma/tumor, Follicular dendritic cell sarcoma/tumor, and Dendritic cell sarcoma, not specified otherwise (Jaffe, World Health Organization classification of tumors 2001; 273-289). Recently, Pileri et al. provided a comprehensive immunohistochemical classification of histiocytic and dendritic cell tumors (Pileri et al., Histopathology 2002;59:161-167). In this article, a concise overview regarding the pathological, clinical, and therapeutic aspects of follicular dendritic, interdigitating dendritic, and Langerhans' cell tumors is presented.
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, The George Washington University Medical Center, Washington, DC 20037, USA.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Kairouz
authors.forename: Jana
authors.initials: J
authors.lastname: Hashash
authors.forename: Wadih
authors.initials: W
authors.lastname: Kabbara
authors.forename: Wassim
authors.initials: W
authors.lastname: McHayleh
authors.forename: Imad A
authors.initials: IA
authors.lastname: Tabbara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D003713:Dendritic Cells / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D020566:Dendritic Cells, Follicular / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D012509:Sarcoma / Q000145:classification / Q000473:pathology* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000145:classification / Q000473:pathology* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins