Novel functionalized pyridine-containing DTPA-like ligand. Synthesis, computational studies and characterization of the corresponding Gd(III) complex.
A novel pyridine-containing DTPA-like ligand, carrying additional hydroxymethyl groups on the pyridine side-arms, was synthesized in 5 steps. The corresponding Gd(III) complex, potentially useful as an MRI contrast agent, was prepared and characterized in detail by relaxometric methods and its structure modeled by computational methods.
Artali
Roberto
R
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Università degli Studi di Milano, Viale Abruzzi 42, 20131 Milan, Italy. roberto.artali@tiscali.it
Botta
Mauro
M
Cavallotti
Camilla
C
Giovenzana
Giovanni B
GB
Palmisano
Giovanni
G
Sisti
Massimo
M
D005682:Gadolinium / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D004369:Pentetic Acid / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013696:Temperature
D008024:Ligands; D011725:Pyridines; D004369:Pentetic Acid; D005682:Gadolinium; C023666:pyridine