Growth hormone therapy in progeria.
Catabolic processes seen in Hutchinson-Gilford progeria resemble those of normal aging and, in the affected children, usually result in death at an early age. In addition to its growth promoting effects, growth hormone (GH) has potent anabolic properties. Administration of GH ameliorates some of the catabolic effects of normal aging. We report the results of GH treatment in a young child with progeria.
Sadeghi-Nejad
Ab
A
Division of Pediatric Endocrinology, Tufts University School of Medicine, Floating Hospital for Children, Tufts-New England Medical Center, Boston, MA 02111, USA. asadeghi@tufts-nemc.org
Demmer
Laurie
L
D019588:Aging, Premature / Q000235:genetics; D002675:Child, Preschool; D017809:Fatal Outcome; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007797:Laminin / Q000235:genetics; D008297:Male; D009154:Mutation; D011371:Progeria / Q000188:drug therapy* / Q000235:genetics
D007797:Laminin; C084098:laminin A; D013006:Growth Hormone