Uncertainties in individual doses in a case-control study of thyroid cancer after the Chernobyl accident.
Individual radiation doses to the thyroid were reconstructed for 2239 subjects of a case-control study of thyroid cancer among young people that was carried out in regions of Belarus and Russia contaminated by radioactive fallout from the Chernobyl accident. Although the process of dose reconstruction provides a point estimate of each subject's dose, it is obvious that there is uncertainty associated with these dose calculations. The following main sources of uncertainty in the estimated individual doses were identified: (1) shared and unshared errors associated with parameters of the dosimetry model; and (2) unshared errors that are associated with the variability, reliability and ability of information from the personal interviews. Besides setting up proper distributions for the parameters of the dosimetry model, inter-individual correlations were also defined to take into account shared errors. By the application of Monte Carlo simulations, a set of approximately log-normally distributed thyroid doses was obtained for each subject; the geometric standard deviations of the distributions are found to vary among individuals from 1.7 to 3.7.
Drozdovitch
V
V
International Agency for Research on Cancer, 150 cours Albert-Thomas, 69372 Lyon Cedex 08, France. drozdovv@mail.nih.gov
Maceika
E
E
Khrouch
V
V
Zvonova
I
I
Vlasov
O
O
Bouville
A
A
Cardis
E
E
D001822:Body Burden; D016022:Case-Control Studies; D047852:Chernobyl Nuclear Accident; D003627:Data Interpretation, Statistical; D006801:Humans; D015994:Incidence; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000706:statistics & numerical data*; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000453:epidemiology*