Predominance of Candida tropicalis bloodstream infections in a Singapore teaching hospital.
An 18-month epidemiologic investigation of Candida bloodstream infections in a Singapore hospital identified 52 candidemic patients: 36% of whose infections were caused by C. tropicalis, 29% were due to C. albicans, 10% with C. parapsilosis and 21% involved C. glabrata. A predominant clonal C. tropicalis strain was demonstrated. No association with ICU stay, prior exposure to fluconazole/broad-spectrum antibiotics or increased mortality was found in this apparent shift towards non-C. albicans Candida species as the primary agents of candidemia.
Chai
Yi Ann Louis
YA
Department of Medicine, National University Hospital, Singapore. chailouis@hotmail.com
Wang
Yue
Y
Khoo
Ai Leng
AL
Chan
Fong Yee
FY
Chow
Carol
C
Kumarasinghe
Gamini
G
Singh
Kamaljit
K
Tambyah
Paul Ananth
PA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000494:pharmacology; D002175:Candida / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D041022:Candida tropicalis / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D002177:Candidiasis / Q000453:epidemiology / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D004271:DNA, Fungal / Q000032:analysis; D005260:Female; D015725:Fluconazole / Q000494:pharmacology; D016469:Fungemia / Q000453:epidemiology* / Q000382:microbiology; D006784:Hospitals, Teaching; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D017720:Molecular Epidemiology; D019105:Random Amplified Polymorphic DNA Technique; D012846:Singapore / Q000453:epidemiology
D000935:Antifungal Agents; D004271:DNA, Fungal; D015725:Fluconazole