A novel binuclear palladium complex with benzothiazole-2-thiolate: synthesis, crystal structure and interaction with DNA.
The novel Pd(II) complex, [Pd(2)(micro-bzta)(4)].1.5DMSO (where bzta=benzothiazole-2-thiolate) has been synthesized and structurally characterized by element analysis, IR and single-crystal X-ray diffractometry. In the binuclear complex, two palladium(II) are bridged by four deprotonated benzothiazole-2-thialate in a head to tail disposition and the distance of the two Pd(II) is 2.747 A. Three-dimensional structure of the complex was constructed though S...S (3.339 A) weak interaction and pi...pi stack. The binding of the title complex with fish sperm DNA (FS-DNA) has been investigated by absorption and fluorescence spectra. The results indicate that the complex bind to FS-DNA in an intercalative mode and the intrinsic binding constant K of the title complex with FS-DNA is about 1.2 x 10(4)M(-1). Gel electrophoresis assay demonstrates the ability of the complex to cleave the pUC19 plasmid DNA.
Gao
En-Jun
EJ
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang 110142, China. ejgao@yahoo.com.cn
Wang
Ke-Hua
KH
Gu
Xiao-Fu
XF
Yu
Ying
Y
Sun
Ya-Guang
YG
Zhang
Wang-Zhong
WZ
Yin
Hong-Xi
HX
Wu
Qiong
Q
Zhu
Ming-Chang
MC
Yan
Xiao-Mei
XM
D000818:Animals; D052160:Benzothiazoles / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D004587:Electrophoresis, Agar Gel; D005399:Fishes; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013057:Spectrum Analysis
D052160:Benzothiazoles; D010165:Palladium; D004247:DNA