[Progress in the research of antizyme].
Antizyme is a small protein induced by elevated intracellular polyamines. Antizyme binds specifically to ornithine decarboxylase (ODC) , targeting ODC for ubiquitin-independent degradation by the 26S protosome, which consequently reduces polyamine synthesis. Polyamine transport may also be regulated by antizyme, through which the cellular polyamine levels are maintained. In recent years, more and more studies focus on antizyme with the development of biotechnique. In this article, advancements in the antizyme family, synthesis, function and intracellular location are reviewed.
Ma
Jian-Min
JM
College of life sciences, Henan Normal University, Xinxiang 453007, China.
He
Jun-Tao
JT
Ning
Qian-Ji
QJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D006801:Humans; D008969:Molecular Sequence Data; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism*; D011506:Proteins / Q000502:physiology*
D011073:Polyamines; D011506:Proteins; C031017:ornithine decarboxylase antizyme; D009955:Ornithine Decarboxylase