[Effect of aminothiol anthihypoxants on hydration and peroxidation processes in traumatic brain injury].
The hydration (content of total, bound, and free water) and the activity of lipid peroxidation (LPO) processes in the brain have been studied in rats on the background of traumatic brain injury (TBI) dynamics. It is established that aminothiol-based anthihypoxants such as bemithyl and amthizol in a dose of 25 mg/kg alleviate changes induced by TBI. In particular, the drugs decrease the content of total and free water, increase the level of bound water, and inhibit the LPO intensity in the brain. The effect of drugs is more pronounced on the 4th and 7th day after TBI model induction.
Novikov
V E
VE
Ponamareva
N S
NS
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D001930:Brain Injuries / Q000378:metabolism*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D013830:Thiadiazoles / Q000494:pharmacology*; D014867:Water / Q000032:analysis / Q000378:metabolism; D014883:Water-Electrolyte Imbalance / Q000378:metabolism*
D000975:Antioxidants; D001562:Benzimidazoles; D013830:Thiadiazoles; D014867:Water; C044365:amtizol; C049825:bemethyl