title: Question 3: the problem of macromolecular sequences: the forgotten stumbling block.
abstract: The Author agrees in principle with the question/statement, but states also that an important qualification is needed within this question. In fact, it is not possible by the bottom up approach to find the conditions for the synthesis of our actual proteins-lysozyme, chymotrypsin or the like--however it is possible to show experimentally that co-oligopeptides chains of that length can be produced by prebiotic reactions. Considering such a synthesis, it is important to recall that proteins-and nucleic acids-are not simply polymers, but are co-polymers, and the kinetics and thermodynamics attending the synthesis of copolymers poses stringent constraints for the biogenesis and growth of specific sequences. Such constraints are examined and discussed.
authors.affiliation: Biology Department, University of RomaTre, Viale G. Marconi 446, 00146, Rome Italy. luisi@mat.ethz.ch
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Luisi
mesh_terms: D046911:Macromolecular Substances / Q000737:chemistry / Q000378:metabolism; D008962:Models, Theoretical; D011108:Polymers / Q000737:chemistry
chemical_list: D046911:Macromolecular Substances; D011108:Polymers