Thymosin beta4 and angiogenesis: modes of action and therapeutic potential.
Here we review the mechanisms by which Thymosin beta4 (Tbeta4) regulates angiogenesis, its role in processes, such as wound healing and tumour progression and we discuss in more detail the role of Tbeta4 in the cardiovascular system and significant recent findings implicating Tbeta4 as a potential therapeutic agent for ischaemic heart disease.
Smart
Nicola
N
Molecular Medicine Unit, UCL-Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Rossdeutsch
Alex
A
Riley
Paul R
PR
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000098:blood supply; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D013947:Thymosin / Q000502:physiology*; D014945:Wound Healing; D000099201:Thymosin beta(4)
D013947:Thymosin; D000099201:Thymosin beta(4)