Lactic acidosis after treatment with linezolid.
Linezolid is currently indicated to treat vancomycin-resistant Enterococcus faecium infections, nosocomial pneumonia caused by Staphylococcus aureus or Streptococcus pneumoniae, complicated and uncomplicated skin and skin structure infections, and community-acquired pneumonia. We report a case of linezolid-induced lactic acidosis during treatment of vancomycin-resistant enterococcal bacteremia after mitral valve replacement and permanent pacemaker implantation. We also review the current literature describing other cases of linezolid-associated hyperlactatemia.
Wiener
M
M
Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA. mwiener@montefiore.org
Guo
Y
Y
Patel
G
G
Fries
B C
BC
D000081:Acetamides / Q000009:adverse effects*; D000140:Acidosis, Lactic / Q000139:chemically induced*; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D016983:Enterococcus / Q000187:drug effects; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D000069349:Linezolid; D023303:Oxazolidinones / Q000009:adverse effects*; D020713:Vancomycin Resistance / Q000187:drug effects*
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid