Lipophilicity and antiproliferative activity profiling of 2-benzylidencycloalkanones.
High performance liquid chromatographic (HPLC) method has been developed to separate the members of a library including 24 benzylidenecycloalkanone-type structures and to characterize their lipophilicity. The experimental lipophilicity data (k) of the compounds have been compared with their calculated lipophilicity parameters (CLOGP). In general, good correlations between the measured and calculated lipophilicities have been found and these results were in good accordance with our previously data obtained in case of structurally related molecular libraries. In addition, cytotoxicity screening has been performed to determine the antiproliferative activity of these compounds. Some of the investigated compounds possessed noticeable inhibitory potential. Based on the correlation between the antiproliferative activity and experimentally determined lipophilicity of the molecules investigated, limited structural demands to obtain more potent compounds can be exhibited to support the synthetic design.
Hallgas
Balázs
B
Hungarian Academy of Sciences, Peptidbiochemical Research Group in Semmelweis University, Department of Medical Chemistry, H-1088 Budapest, Puskin u. 9, Hungary.
Dobos
Zsófia
Z
Agócs
Attila
A
Idei
Miklós
M
Kéri
György
G
Loránd
Tamás
T
Mészáros
György
G
D000473:Alkanes / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D008055:Lipids / Q000737:chemistry*; D021281:Quantitative Structure-Activity Relationship
D000473:Alkanes; D008055:Lipids