title: Low glycaemic index or low glycaemic load diets for overweight and obesity.
abstract: BACKGROUND
  Obesity is increasingly prevalent, yet the nutritional management remains contentious. It has been suggested that low glycaemic index or load diets may stimulate greater weight loss than higher glycaemic index or load diets or other weight reduction diets.
  
  
  OBJECTIVE
  To assess the effects of low glycaemic index or load diets for weight loss in overweight or obese people.
  
  
  METHODS
  Trials were identified through The Cochrane Library, MEDLINE, EMBASE, CINAHL and manual searches of bibliographies.
  
  
  METHODS
  Randomised controlled trials comparing a low glycaemic index or load diet (LGI) with a higher glycaemic index or load diet or other diet (Cdiet) in overweight or obese people.
  
  
  METHODS
  Two authors independently selected trials, assessed quality and extracted data, including any information provided on adverse effects.
  
  
  RESULTS
  We identified six eligible randomised controlled trials (total of 202 participants). Interventions ranged from five weeks to six months duration with up to six months follow-up after the intervention ceased. The decrease in body mass (WMD -1.1 kg, 95% confidence interval (CI) -2.0 to -0.2, P < 0.05) (n = 163), total fat mass (WMD -1.1 kg, 95% CI -1.9 to -0.4, P < 0.05) (n =147) and body mass index (WMD -1.3, 95% CI -2.0 to -0.5, P < 0.05) (n = 48) was significantly greater in participants receiving LGI compared to Cdiets. The decrease in total cholesterol was significantly greater with LGI compared to Cdiets (WMD -0.22 mmol/L, 95% CI -0.43 to -0.02, P < 0.05), as was the change in LDL-cholesterol (WMD -0.24 mmol/L, 95% CI -0.44 to -0.05, P < 0.05). No study reported adverse effects, mortality or quality of life data.
  
  
  CONCLUSIONS
  Overweight or obese people on LGI lost more weight and had more improvement in lipid profiles than those receiving Cdiets. Body mass, total fat mass, body mass index, total cholesterol and LDL-cholesterol all decreased significantly more in the LGI group. In studies comparing ad libitum LGI diets to conventional restricted energy low-fat diets, participants fared as well or better on th LGI diet, even though they could eat as much as desired. Lowering the glycaemic load of the diet appears to be an effective method of promoting weight loss and improving lipid profiles and can be simply incorporated into a person's lifestyle. Further research with longer term follow-up will determine whether improvement continues long-term and improves quality of life.
authors.affiliation: University of Sydney, Children's Hospital at Westmead, CEBPGAN (Centre for Evidence Based Paediatrics Gastroenterology and Nutrition), Locked Bag 4001, Westmead, Australia, NSW 2145. dianat@chw.edu.au
authors.forename: D E
authors.initials: DE
authors.lastname: Thomas
authors.forename: E J
authors.initials: EJ
authors.lastname: Elliott
authors.forename: L
authors.initials: L
authors.lastname: Baur
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood; D004038:Diet, Reducing; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005260:Female; D038321:Glycemic Index; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D050177:Overweight; D016032:Randomized Controlled Trials as Topic; D015431:Weight Loss
chemical_list: D004040:Dietary Carbohydrates