Synthesis and applications of a novel polymer-supported EEDQ reagent.
A simple synthetic protocol for a novel polymer-supported EEDQ reagent is reported. This reagent promotes solution-phase amide bond formation without any additives or base, as well as the selective coupling of aliphatic amines with acids in the presence of aromatic amines.
Kakarla
Ramesh
R
Early Discovery Chemistry, Bristol-Myers Squibb R&D, 5 Research Parkway, Wallingford, Connecticut 06492-7600, USA. ramesh.kakarla@bms.com
Li
Guo
G
Gerritz
Samuel W
SW
D007202:Indicators and Reagents / Q000138:chemical synthesis*; D011108:Polymers / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D011108:Polymers; D011804:Quinolines; C000470:EEDQ