A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum.
Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in (glyco)protein quality control.
Ploegh
Hidde L
HL
Whitehead Institute, MIT Department of Biology, Cambridge, Massachusetts 02142, USA. ploegh@wi.mit.edu
D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000737:chemistry* / Q000378:metabolism* / Q000821:virology; D006023:Glycoproteins / Q000737:chemistry* / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000096:biosynthesis / Q000737:chemistry*; D008954:Models, Biological; D017510:Protein Folding
D006023:Glycoproteins; D008055:Lipids