title: Chromosome aberration test of Pigment Yellow 34 (lead chromate) in Chinese hamster ovary cells.
abstract: Lead chromate pigment in the form of the commercial pigment, Pigment Yellow 34, CAS No. 1344-37-2, used in the plastics and coatings industries, did not induce chromosome aberrations in Chinese hamster ovary (CHO) cell line WB(L). Lead chromate pigment is essentially insoluble in water, and in an effort to test the material under realistic conditions, no attempt to solubilize the pigment was made. These results are significant because others have reported lead chromate to cause genotoxicity in various assays, but only under conditions in which its aqueous solubility was artificially enhanced.
authors.affiliation: Cantox Health Sciences International, 2233 Argentia Road, Mississauga, Ont. L5N 2X7, Canada. enestmann@cantox.com
authors.forename: Earle R
authors.initials: ER
authors.lastname: Nestmann
authors.forename: Baowei
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000818:Animals; D016466:CHO Cells; D016923:Cell Death; D002840:Chromates / Q000633:toxicity*; D002869:Chromosome Aberrations / Q000139:chemically induced*; D004396:Coloring Agents / Q000633:toxicity*; D006224:Cricetinae; D003412:Cricetulus; D006863:Hydrogen-Ion Concentration; D007854:Lead / Q000633:toxicity*; D009152:Mutagenicity Tests; D009994:Osmolar Concentration; D012996:Solutions
chemical_list: D002840:Chromates; D004396:Coloring Agents; D012996:Solutions; D007854:Lead; C031895:lead chromate