[Autoantibodies to light myosin chains as an early marker of damage to the myocardium].
The concentration of autoantibodies to myosin light chains in the blood serum of patients who have undergone operation on heart under conditions of artificial hypothermal circulation was measured after 3, 6, 9, 18, 24, 36 h following the reperfusion of myocardium. According to the postoperative data, the patients were divided into three groups: patients with stable hemodynamics in the postoperative period (group 1); patients with myocardial stunning following reperfusion of myocardium (group 2); and patients with severe heart failure that developed in early postoperative period (group 3). Significant differences in the concentration of autoantibodies to myosin light chains have been found between the groups. A high correlation was established between the duration of cross-clamping of aorta and the concentration of autoantibodies. By means of multivariant regression analysis, factors characterizing the initial severity of disease that can influence the concentration of autoantibodies to myosin light chains in blood have been revealed.
Bledzhiants
D A
DA
Muratov
R M
RM
Podlubnaia
Z A
ZA
D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D006348:Cardiac Surgical Procedures; D005112:Extracorporeal Circulation / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000209:etiology; D017682:Myocardial Stunning / Q000175:diagnosis* / Q000209:etiology; D009206:Myocardium / Q000276:immunology*; D018994:Myosin Light Chains / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers; D018994:Myosin Light Chains