title: Update in the management of ovarian and cervical carcinoma.
abstract: Ovarian and cervical cancers are significant health problems. This article provides an update in selected management topics. Paclitaxel and platinum derivatives are the first-line treatment for patients with advanced disease. In selected patients, intraperitoneal chemotherapy has been associated with improved survival but the broad applicability of this strategy is limited by issues of toxicity and feasibility. Management of patients with recurrent disease is based on a number of factors and includes surgery in selected cases, platinum-based chemotherapy for patients with platinum-sensitive disease and other agents such as topotecan and pegylated liposomal formulation of doxorubicin for patients with platinum-resistant disease. In cervical cancer, the most significant issue/event is the demonstration of superior survival with topotecan and cisplatin compared to cisplatin alone. Finally, new agents such as epidermal growth factor receptor inhibitors and antiangiogenic agents are being currently tested in these settings.
authors.affiliation: Servicio de Oncología Médica, Instituto Valenciano de Oncología, Valencia, Spain. apoveda@fivo.org
authors.forename: A
authors.initials: A
authors.lastname: Poveda
authors.forename: R
authors.initials: R
authors.lastname: Salazar
authors.forename: J M
authors.initials: JM
authors.lastname: del Campo
authors.forename: C
authors.initials: C
authors.lastname: Mendiola
authors.forename: J
authors.initials: J
authors.lastname: Cassinello
authors.forename: B
authors.initials: B
authors.lastname: Ojeda
authors.forename: J A
authors.initials: JA
authors.lastname: Arranz
authors.forename: A
authors.initials: A
authors.lastname: Oaknin
authors.forename: J
authors.initials: J
authors.lastname: García-Foncillas
authors.forename: M J
authors.initials: MJ
authors.lastname: Rubio
authors.forename: A
authors.initials: A
authors.lastname: González Martín
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy*; D002945:Cisplatin / Q000627:therapeutic use; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D066246:ErbB Receptors; D002945:Cisplatin