title: Synthesis, X-ray structure, and pharmacological activity of some 6,6-disubstituted chromeno[4,3-b]- and chromeno- [3,4-c]-quinolines.
abstract: Some chromeno[4,3-b]quinolines 4a-i were obtained from beta-chloro carboxyaldehydes 3a-c with different aniline derivatives namely, aniline, 4-fluoroaniline, and 2-aminophenol. Surprisingly, 3a-c reacted with 2-aminothiophenol and afforded the chromeno[3,4-c]quinoline derivatives 5a-c. Single-crystal X-ray diffraction studies of 4e and 5b provided good support for the established structure. Compounds 4b and 5b showed significant anti-inflammatory and ulcerogenic score activities compared to that of indomethacin.
authors.affiliation: Department of Chemistry, Cairo University, Cairo, Egypt. mihegab65@yahoo.com
authors.forename: Mohamed I
authors.initials: MI
authors.lastname: Hegab
authors.forename: Abdel-Samee M
authors.initials: AS
authors.lastname: Abdel-Fattah
authors.forename: Nabil M
authors.initials: NM
authors.lastname: Yousef
authors.forename: Hany F
authors.initials: HF
authors.lastname: Nour
authors.forename: A M
authors.initials: AM
authors.lastname: Mostafa
authors.forename: Mohey
authors.initials: M
authors.lastname: Ellithey
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D005260:Female; D008297:Male; D051379:Mice; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D011804:Quinolines