Non-typhoidal Salmonella bacteremia in adults.
OBJECTIVE
Very few studies have examined prognostic factors in adult patients with non-typhoidal Salmonella (NTS) bacteremia. The purpose of this study was to identify the prognostic factors of these patients.


METHODS
A total of 79 episodes of NTS bacteremia were identified in 73 patients between January 2001 and December 2003. Susceptibilities to various antimicrobials were determined using disk-diffusion tests and National Committee for Clinical Laboratory Standards criteria. Multiple logistic regression was used to evaluate the relationship between patients' characteristics and covariates of mortality.


RESULTS
There were only 5 episodes (6%) of gastroenteritis, two of which were due to Salmonella septicemia contracted abroad. Potentially predisposing factors were identifiable in 51 episodes (65%). Infections in 24 patients (30%) were due to serogroup B Salmonella and in 22 patients (28%), to serogroup C Salmonella. A logistic regression analysis selected two variables as independently influencing prognosis: coma (p=0.006) and septic shock (p=0.002).


CONCLUSIONS
Thus, most adult patients with NTS bacteremia do not develop gastroenteritis. Patients in shock or coma have poor prognosis, and susceptibility to third-generation cephalosporins, cefepime, and carbapenem is high.
Yen
Yung Feng
YF
Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, and National Yang-Ming University, Taipei, Taiwan.
Lin
Yi Chun
YC
Chen
Te Li
TL
Chen
Yin Yin
YY
Lin
Mei Lin
ML
Wang
Fu Der
FD
Liu
Chen Yi
CY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000627:therapeutic use*; D016470:Bacteremia / Q000382:microbiology / Q000503:physiopathology*; D003128:Coma; D024881:Drug Resistance, Bacterial; D005260:Female; D005759:Gastroenteritis / Q000382:microbiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012475:Salmonella / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D012480:Salmonella Infections / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*; D012772:Shock, Septic / Q000382:microbiology / Q000503:physiopathology
D000900:Anti-Bacterial Agents