Pediatric renal cell carcinoma with oncocytoid features occurring in a child after chemotherapy for cardiac leiomyosarcoma.
We report a case of renal cell carcinoma (RCC) with extensive oncocytoid features developing in a 12-year-old African-American boy after chemotherapy for cardiac leiomyosarcoma at 3 months of age. The tumor showed histopathologic features similar to those previously reported in RCC after chemotherapy for neuroblastoma and now considered a specific entity in the World Health Organization classification of renal tumors as "RCC associated with neuroblastoma." Our report expands the spectrum of tumors (beyond neuroblastoma) in which RCCs with such an appearance can arise in the pediatric age group after chemotherapy.
Dhall
Deepti
D
Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Al-Ahmadie
Hikmat A
HA
Dhall
Girish
G
Shen-Schwarz
Susan
S
Tickoo
Satish K
SK
D002292:Carcinoma, Renal Cell / Q000473:pathology*; D002648:Child; D006338:Heart Neoplasms / Q000188:drug therapy*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D007890:Leiomyosarcoma / Q000188:drug therapy*; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*