Aqueous self-assembly of phytantriol in ternary systems: effect of monoolein, distearoylphosphatidylglycerol and three water-miscible solvents.
The aqueous phase behavior of phytantriol (PT) in mixtures of monoolein (MO), distearoylphosphatidylglycerol (DSPG), propylene glycol (PG), polyethylene glycol 400 (PEG 400) and 2-methyl-2,4-pentanediol (MPD) was investigated by visual inspection, polarized light microscopy and small angle X-ray diffraction at room temperature. The phase diagrams of PT and MO in water are qualitatively very similar and PT/MO mixtures in excess water form one cubic phase of space group Pn3m irrespective of mixing ratio. The addition of the charged membrane lipid DSPG to the PT system gives rise to a considerable water swelling of the cubic phases as well as the occurrence of a cubic phase of space group Im3m. Whereas all three solvents studied give rise to a sponge (L3) phase in the MO-water system, this phase was only found when MPD was added to the PT-water system. The results are discussed with respect to the chemical differences between PT and MO.
Wadsten-Hindrichsen
Pia
P
Pharmaceutical Technology, Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Göteborg, Sweden.
Bender
Johanna
J
Unga
Johan
J
Engström
Sven
S
D005233:Fatty Alcohols / Q000737:chemistry*; D005989:Glycerides / Q000737:chemistry*; D006018:Glycols; D008567:Membranes, Artificial; D010715:Phosphatidylglycerols / Q000737:chemistry*; D011092:Polyethylene Glycols; D019946:Propylene Glycol; D053838:Scattering, Small Angle; D012997:Solvents; D013816:Thermodynamics; D053835:Unilamellar Liposomes; D014867:Water; D014961:X-Ray Diffraction
D005233:Fatty Alcohols; D005989:Glycerides; D006018:Glycols; D008567:Membranes, Artificial; D010715:Phosphatidylglycerols; D012997:Solvents; D053835:Unilamellar Liposomes; D014867:Water; D011092:Polyethylene Glycols; C084352:distearoyl phosphatidylglycerol; D019946:Propylene Glycol; C508873:3,7,11,15-tetramethyl-1,2,3-hexadecanetriol; C005953:monoolein; C011480:hexylene glycol