The realized niche of adult neural stem cells.
This review gives an overview of current issues concerning the application of the concept of the stem cell niche to the adult mammalian brain. It describes how the niche manifests itself at different structural levels as well as the main applications that are influenced by this concept. Finally, special regard is given to what is known for the adult human brain and how far the findings from lower animals can be applied in harnessing the regenerative potential of stem cells for therapy.
Nern
Christian
C
Institute of Neurology (Edinger Institute), University of Frankfurt, D-60528 Frankfurt am Main, Germany.
Momma
Stefan
S
D053687:Adult Stem Cells / Q000166:cytology*; D000375:Aging; D000818:Animals; D001808:Blood Vessels / Q000166:cytology; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009457:Neuroglia / Q000166:cytology; D009474:Neurons / Q000166:cytology*