title: Latency analysis of single auditory evoked M100 responses by spatio-temporal filtering.
abstract: Appropriate spatial filtering followed by temporal filtering is well suited for the single-trial analysis of multi-channel magnetoencephalogram or electroencephalogram recordings. This is demonstrated by the results of a single-trial latency analysis obtained for auditory evoked M100 responses from nine subjects using two different stimulation frequencies. Spatial filters were derived automatically from the data via noise-adjusted principle component analysis, and single-trial latencies were estimated from the signal phase after complex bandpass filtering. For each of the two stimulation frequencies, estimated single-trial latencies were consistent with results obtained from a standard approach using averaged evoked responses. The quality of the estimated single-trial latencies was additionally assessed by their ability to separate between the two different stimulation frequencies. As a result, more than 80% of the single trials can be classified correctly by their estimated latencies.
authors.affiliation: Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany. gerd.wuebbeler@ptb.de
authors.forename: G
authors.initials: G
authors.lastname: Wübbeler
authors.forename: A
authors.initials: A
authors.lastname: Link
authors.forename: M
authors.initials: M
authors.lastname: Burghoff
authors.forename: L
authors.initials: L
authors.lastname: Trahms
authors.forename: C
authors.initials: C
authors.lastname: Elster
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D000465:Algorithms; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D010898:Pitch Perception / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity