title: Identification of two novel HLA-DRB1*11 alleles (DRB1*110404 and DRB1*1161) in two Italian cord blood units.
abstract: We describe the isolation and characterization of two novel HLA-DRB1*11 alleles, officially named DRB1*1161 and 110404. These two new variants were both identified in two Caucasoid individuals. The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC>AAC) is responsible for an amino-acidic change from Asp to Asn. The exon 2 sequence of the second novel allele described here, DRB1*110404, differs from that of DRB1*110401 only at codon 34 where the nucleotidic change CAA>CAG gives rise to a silent mutation.
authors.affiliation: Dipartimento di Medicina Rigenerativa-Immunologia dei Trapianti di Organi e Tessuti, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Via Francesco Sforza 35, 20122 Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Longhi
authors.forename: S
authors.initials: S
authors.lastname: Frison
authors.forename: M
authors.initials: M
authors.lastname: Serafini
authors.forename: K
authors.initials: K
authors.lastname: Karpasitou
authors.forename: F
authors.initials: F
authors.lastname: Poli
mesh_terms: D000483:Alleles; D005312:Fetal Blood; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007558:Italy; D044465:White People / Q000235:genetics
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553518:HLA-DRB1*11:01:01 antigen