title: Limonoids from the stem bark of Khaya grandifoliola.
abstract: Three limonoids, deacetylkhayanolide E (1), 6S-hydroxykhayalactone (2), and grandifolide A (3), along with three known ones, were isolated from stem bark of the Nigerian medicinal plant Khaya grandifoliola. Their structures were characterized on the basis of the application of spectroscopic methods. In vitro antimicrobial and cytotoxic activities of the isolates were also tested, but were all found to be inactive.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Oluwatoyin A
authors.initials: OA
authors.lastname: Odeku
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D036701:Limonins / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D008826:Microbial Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*
chemical_list: D036701:Limonins