title: Serum interleukin-6 in patients with burning mouth syndrome and relationship with depression and perceived pain.
abstract: OBJECTIVE
  To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients.
  
  
  METHODS
  48 BMS patients and 31 healthy controls participated in the study. Serum interleukin-6 was measured by means of ELISA. Hamilton rating scale of depression (HRSD) and visual analogue scale (VAS) were used to quantitate depressive status and pain levels of subjects, respectively.
  
  
  RESULTS
  15 (31%) patients displayed substantial depressive symptoms (HRSD > or = 16). HRSD scores of patients were significantly higher than controls and positively correlated to their VAS values (P = .002). Serum interleukin-6 in patients was much lower than controls and negatively correlated to their VAS values (P = .011). However, no significant relations were found between interleukin-6 and HRSD scores (P = .317).
  
  
  CONCLUSIONS
  Serum interleukin-6 in patients with burning mouth syndrome is decreased and negatively correlated to chronic pain. Both psychological and neuropathic disorders might act as precipitating factors in BMS etiopathogenesis.
authors.affiliation: Department of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Qianming
authors.initials: Q
authors.lastname: Chen
authors.forename: Juan
authors.initials: J
authors.lastname: Xia
authors.forename: Mei
authors.initials: M
authors.lastname: Lin
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhou
authors.forename: Bingqi
authors.initials: B
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002054:Burning Mouth Syndrome / Q000097:blood* / Q000523:psychology; D003863:Depression / Q000097:blood* / Q000523:psychology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000097:blood* / Q000523:psychology; D017288:Pain Threshold
chemical_list: D015850:Interleukin-6