Characterization of antibody-binding sites on proteins: development of a knowledgebase and its applications in improving epitope prediction.
Immunoinformatics provides tools for reverse vaccinology and encompasses development of knowledge bases and algorithms for prediction of epitopes. AgAbDb, a database archiving molecular interactions of antigen-antibody co-crystal structures, has been developed (http://202.41.70.51:8080/agabdb2/). Analyses of antibody-binding sites on proteins helped to fine-tune the parameters for prediction of sequential and conformational B-cell epitopes.
Ghate
A D
AD
Bioinformatics Centre, University of Pune, Pune 411007, India.
Bhagwat
B U
BU
Bhosle
S G
SG
Gadepalli
S M
SM
Kulkarni-Kale
U D
UD
D000465:Algorithms; D000937:Antigen-Antibody Reactions / Q000276:immunology; D001666:Binding Sites, Antibody / Q000276:immunology; D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D018985:Epitopes, B-Lymphocyte / Q000276:immunology; D051188:Knowledge Bases; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D014584:User-Computer Interface
D018985:Epitopes, B-Lymphocyte