title: Genetic variation in prehistoric Sardinia.
abstract: We sampled teeth from 53 ancient Sardinian (Nuragic) individuals who lived in the Late Bronze Age and Iron Age, between 3,430 and 2,700 years ago. After eliminating the samples that, in preliminary biochemical tests, did not show a high probability to yield reproducible results, we obtained 23 sequences of the mitochondrial DNA control region, which were associated to haplogroups by comparison with a dataset of modern sequences. The Nuragic samples show a remarkably low genetic diversity, comparable to that observed in ancient Iberians, but much lower than among the Etruscans. Most of these sequences have exact matches in two modern Sardinian populations, supporting a clear genealogical continuity from the Late Bronze Age up to current times. The Nuragic populations appear to be part of a large and geographically unstructured cluster of modern European populations, thus making it difficult to infer their evolutionary relationships. However, the low levels of genetic diversity, both within and among ancient samples, as opposed to the sharp differences among modern Sardinian samples, support the hypothesis of the expansion of a small group of maternally related individuals, and of comparatively recent differentiation of the Sardinian gene pools.
authors.affiliation: Dipartimento di Biologia Animale e Genetica, Laboratorio di Antropologia, Università di Firenze, Firenze, Italy.
authors.forename: David
authors.initials: D
authors.lastname: Caramelli
authors.forename: Cristiano
authors.initials: C
authors.lastname: Vernesi
authors.forename: Simona
authors.initials: S
authors.lastname: Sanna
authors.forename: Lourdes
authors.initials: L
authors.lastname: Sampietro
authors.forename: Martina
authors.initials: M
authors.lastname: Lari
authors.forename: Loredana
authors.initials: L
authors.lastname: Castrì
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vona
authors.forename: Rosalba
authors.initials: R
authors.lastname: Floris
authors.forename: Paolo
authors.initials: P
authors.lastname: Francalacci
authors.forename: Robert
authors.initials: R
authors.lastname: Tykot
authors.forename: Antonella
authors.initials: A
authors.lastname: Casoli
authors.forename: Jaume
authors.initials: J
authors.lastname: Bertranpetit
authors.forename: Carles
authors.initials: C
authors.lastname: Lalueza-Fox
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bertorelle
authors.forename: Guido
authors.initials: G
authors.lastname: Barbujani
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle; D004272:DNA, Mitochondrial / Q000235:genetics / Q000266:history* / Q000302:isolation & purification; D005580:Fossils; D014644:Genetic Variation; D006239:Haplotypes; D049690:History, Ancient; D006801:Humans; D007558:Italy; D016133:Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid; D014070:Tooth / Q000737:chemistry
chemical_list: D004272:DNA, Mitochondrial