Effect of fluoxetine alone and in combination with sildenafil in patients with premature ejaculation.
BACKGROUND
The aim of this study was to compare the efficacy of fluoxetine alone and combined with sildenafil in patients complaining of premature ejaculation.


METHODS
Ninety-one married potent men, 21-43 years old, with premature ejaculation but without any obvious organic cause were enrolled. Pretreatment evaluation included history, physical examination, and self-administration of the International Index of Erectile Function questionnaire. The patients were randomly divided into two groups: group A patients (n = 48) received 20 mg fluoxetine daily for 4 weeks and then 20 mg as needed 2-3 h before sexual activity for 4 months, and group B patients (n = 43) received group A regimen plus 50 mg sildenafil as needed 1 h before sexual activity for 4 months.


RESULTS
Ejaculatory latency time and intercourse satisfaction significantly improved in group B as compared with group A (p < 0.05).


CONCLUSIONS
Fluoxetine combined with sildenafil seems to provide significantly better ejaculatory latency time and intercourse satisfaction as compared with fluoxetine alone in patients with premature ejaculation.
Hosseini
Mohammad M
MM
Department of Urology, Motahari Hospital, Jahrom University of Medical Sciences, Jahrom, Shiraz, Iran.
Yarmohammadi
Hooman
H
D000328:Adult; D004359:Drug Therapy, Combination; D004542:Ejaculation; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011446:Prospective Studies; D011687:Purines / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*; D000068677:Sildenafil Citrate; D016037:Single-Blind Method; D013450:Sulfones / Q000627:therapeutic use*; D013997:Time Factors
D005473:Fluoxetine; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D017367:Selective Serotonin Reuptake Inhibitors; D000068677:Sildenafil Citrate; D013450:Sulfones