[Synthesis of beta-cyclodextrin polymer beads and its behavior of drug release].
OBJECTIVE
To prepare beta-cyclodextrin polymer (beta-CDP) beads using as a drug carrier and study the release behaviors of Berberine Hydrochlorrde (BH) in beta-CDP beads.


METHODS
beta-CDP beads were synthesized by inverse emulsion polymerization. The inclusion complex between beta-CD and BH were investigated by phase solubility method. And the release of BH in vitro was studied by UV spectra.


RESULTS
Inclusion compounds of beta-CD and BH with 1: 1 molar ratio were found under the condition of pH 1.4 and pH 7.4, with corresponding stability constants of 48.85 L/mol and 122.11 L/mol, respectively. Finally, the controlled release behavior of BH in polymer beads were studied and the release rate of BH kept almost constant after 24 h. Release rate of BH was higher at pH 1.4 than that at pH 7.4.


CONCLUSIONS
beta-CDP beads may be an ideal controlled drug release carrier.
Wu
Wen-juan
WJ
Department of Physical Chemistry, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Zheng
Dun-sheng
DS
Cai
Shi-tian
ST
Huang
Yuan-keng
YK
D002482:Cellulose / Q000138:chemical synthesis / Q000737:chemistry*; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D012995:Solubility
D003505:Cyclodextrins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; C041953:cyclodextrin polymer; D002482:Cellulose