Electrical atrial fibrillation induction affects the characteristics of induced arrhythmia.
Several methods are being used to induce atrial fibrillation (AF) in experimental investigations, which may affect the electrophysiologic parameters of the induced arrhythmia. The aim of our study was the investigation of temporal characteristics of AF during and after electrical induction. Direct current and high-frequency stimulation was used for induction in bipolar biatrial, right and left atrial appendage configurations in 6 dogs. Atrial and ventricular electrical activity was recorded near the bundle of His. Seven statistical parameters were calculated to analyze the temporal characteristics of electrical activity of both chambers. The induction method affected 5 atrial and no ventricular electrophysiologic parameters during stimulation, and the effect disappeared after ceasing induction, during the induced transient or persistent AF. Electrical stimulation affects the properties of the induced arrhythmia during the induction; thus, the investigation of AF is recommended only after ceasing the induction to avoid bias.
Roka
Attila
A
Department of Cardiovascular Surgery, Cardiovascular Centre, Semmelweis University, Budapest, Hungary. attila.roka@gmail.com
Toth
Erika
E
Szilagyi
Szabolcs
S
Merkely
Bela
B
D000818:Animals; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D004285:Dogs; D004558:Electric Stimulation / Q000009:adverse effects*; D006329:Heart Conduction System / Q000503:physiopathology*