title: Stress management: how cells take control of their transposons.
abstract: In this issue of Molecular Cell, Dai et al. (2007) describe their exciting discovery that, in Saccharomyces cerevisiae, the integrase of retrotransposon Ty5 is phosphorylated, and this modification stabilizes the interaction between integrase and Sir4p that directs integration to heterochromatin.
authors.affiliation: Section on Eukaryotic Transposable Elements, Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ebina
authors.affiliation: Section on Eukaryotic Transposable Elements, Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: henry_levin@nih.gov.
authors.forename: Henry L
authors.initials: HL
authors.lastname: Levin
mesh_terms: D004271:DNA, Fungal / Q000235:genetics / Q000378:metabolism; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism; D019426:Integrases / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D010766:Phosphorylation; D018626:Retroelements / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
chemical_list: D004271:DNA, Fungal; D006570:Heterochromatin; D018626:Retroelements; C061573:SIR4 protein, S cerevisiae; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D019426:Integrases