title: Metal-free one-pot oxidative amination of aldehydes to amides.
abstract: Metal-free oxidative amination of aromatic aldehydes in the presence of TBHP provides convenient access to amides in 85-99% under mild reaction conditions within 5 h. This method avoids free carboxylic acid intermediates and integrates aldehyde oxidation and amide bond formation, which are usually accomplished separately, into a single operation. Proline-derived amides can be prepared in excellent yields without noticeable racemization.
authors.affiliation: Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
authors.forename: Kekeli
authors.initials: K
authors.lastname: Ekoue-Kovi
authors.forename: Christian
authors.initials: C
authors.lastname: Wolf
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis*; D000586:Amination; D010100:Oxygen / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000577:Amides; D010100:Oxygen