title: Epithelioid variant of pleomorphic liposarcoma in a heifer.
abstract: A case of epithelioid variant of liposarcoma in a 31-month-old Japanese Black heifer is described. The tumour mass, which formed in the subcutis of the left cheek, was excised surgically, but this was followed by recurrence and metastasis to lymph nodes. The primary tumour was composed of sheets of lipid-laden cells, and anaplastic larger cells with eosinophilic or amphophilic cytoplasm were occasionally seen. In addition to vimentin and S-100 protein expression in the majority of tumour cells, squamous and non-squamous cytokeratins (CKs) were present, mainly in the larger cells, which predominated in the metastatic lesions. The expression of CKs was considered to be evidence of epithelioid differentiation.
authors.affiliation: Chuou Livestock Hygiene Service Centre, 736 Urushiyama, Yamagata 990-2161, Sapporo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suto
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: K
authors.initials: K
authors.lastname: Kadota
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism / Q000473:pathology*; D002610:Cheek; D005260:Female; D007633:Keratins / Q000378:metabolism; D008080:Liposarcoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D014746:Vimentin / Q000378:metabolism
chemical_list: D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins