title: Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant?
abstract: Alzheimer's disease and related dementias are devastating disorders that lead to the progressive decline of cognitive functions. Characteristic features are severe brain atrophy, paralleled by accumulation of beta amyloid and neurofibrillary tangles. With the discovery of neurogenesis in the adult brain, the hopes have risen that these neurodegenerative conditions could be overcome, or at least ameliorated, by the generation of new neurons. The location of the adult neurogenic zones in the hippocampus and the lateral ventricle wall, close to corpus callosum and neocortex, indicates strategic positions for potential repair processes. However, we also need to consider that the generation of new neurons is possibly involved in cognitive functions and could, therefore, be influenced by disease pathology. Moreover, aberrant neurogenic mechanisms could even be a part of the pathological events of neurodegenerative diseases. It is the scope of this review to summarize and analyze the recent data from neurogenesis research with respect to Alzheimer's disease and its animal models.
authors.affiliation: Center for Brain Repair and Rehabilitation, Institute for Neuroscience and Physiology, Göteborg University, Medicianregatan 11, 40530 Göteborg, Sweden. georg.kuhn@neuro.gu.se
authors.forename: H Georg
authors.initials: HG
authors.lastname: Kuhn
authors.forename: Christi M
authors.initials: CM
authors.lastname: Cooper-Kuhn
authors.forename: Karin
authors.initials: K
authors.lastname: Boekhoorn
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Lucassen
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology* / Q000517:prevention & control; D000818:Animals; D001921:Brain / Q000473:pathology; D018797:Cell Cycle Proteins / Q000378:metabolism; D003704:Dementia / Q000473:pathology* / Q000517:prevention & control; D004195:Disease Models, Animal; D004777:Environment; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D051379:Mice; D009474:Neurons / Q000473:pathology*; D016875:tau Proteins / Q000096:biosynthesis / Q000235:genetics
chemical_list: D018797:Cell Cycle Proteins; D016875:tau Proteins