title: The duration of spinal anesthesia with 5% lidocaine in chronic opium abusers compared with nonabusers.
abstract: BACKGROUND
  It has been demonstrated that chronic opium abusers have lower thresholds for pain. In this study we sought to determine whether chronic opium abuse has any effect on the duration of spinal block by local anesthetics.
  
  
  METHODS
  In a case-controlled study, 50 opium abusers and 50 nonabusers undergoing lower abdomen operations were selected from among the patients admitted to a university hospital for elective surgery. All patients received 100 mg hyperbaric preservative-free 5% lidocaine in dextrose, intrathecally.
  
  
  RESULTS
  The duration of anesthesia was much shorter in the opium abusers (60 +/- 7 min) than in the nonabusers (83 +/- 10 min) (P < 0.0001).
  
  
  CONCLUSIONS
  The study documents a shortened duration of spinal block in opium abusers.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Shaheed Beheshti University, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Vosoughian
authors.forename: Ali
authors.initials: A
authors.lastname: Dabbagh
authors.forename: Samira
authors.initials: S
authors.lastname: Rajaei
authors.forename: Hassan
authors.initials: H
authors.lastname: Maftuh
mesh_terms: D000328:Adult; D000775:Anesthesia, Spinal / Q000379:methods*; D016022:Case-Control Studies; D002908:Chronic Disease; D017558:Elective Surgical Procedures / Q000379:methods; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D009293:Opioid-Related Disorders / Q000453:epidemiology* / Q000503:physiopathology; D009892:Opium; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D009892:Opium; D008012:Lidocaine