Functions of endosomal trafficking in Drosophila epithelial cells.
The mechanisms underlying endosomal trafficking have been mostly dissected in yeast and mammalian tissue culture cells. Here, we review recent advances in the understanding of the role of endosomal trafficking in Drosophila epithelial cells. We focus on endosomal pathways that control cell polarization, cell growth, cell fate and epithelial cell rearrangement. We expect that mechanistic studies in mammalian cells and functional studies in invertebrates will continue to synergize to provide a comprehensive view of the role of endosomal trafficking in epithelial tissue organization and functions.
Leibfried
Andrea
A
Institut CURIE, UMR144, Cell Polarity in Drosophila, 26 rue d'Ulm, 75248 Paris, Cedex 05, France.
Bellaïche
Yohanns
Y
D000818:Animals; D002455:Cell Division / Q000502:physiology; D049108:Cell Enlargement; D004330:Drosophila; D011992:Endosomes / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology