Frequency of selected thrombophilias in women with placental abruption.
OBJECTIVE
There is a growing view that inherited or acquired thrombophilia may predispose a woman towards an adverse pregnancy outcome. The aim of this study was to investigate whether risk factors for placental abruption because of such thrombophilias (such as carriership of factor V Leiden (FVL), prothrombin G20210A gene mutation and homozygous MTHFR C677T) might be used as a predictor for placental abruption.


METHODS
A retrospective case-control study conducted at the University Hospital, Palacky University, Olomouc, Czech Republic. One hundred and eighty women with placental abruption out of 20,175 deliveries (0.79%) were compared to 196 unselected gravidae. A detailed medical history was taken with special reference to factors related to hypercoagulation and blood was drawn for polymerase chain reaction analysis. The prevalence of FVL, prothrombin G20210A and MTHFR C677T was related to placental abruption.


RESULTS
The heterozygous form of FVL was present in 20of 142 cases (14.1%) in the placental abruption group, compared to ten of 196 (5.1%) in the control group (odds ratio 3.0, 95% confidence interval 1.4-6.7).


CONCLUSIONS
We found that factor V Leiden is a significant risk factor for placental abruption.
Procházka
Martin
M
Department of Obstetrics and Gynecology, Medical Faculty of Palacký University, Olomouc, Czech Republic. martinprochazka@hotmail.com
Lubuský
Marek
M
Slavík
Ludek
L
Hrachovec
Petr
P
Zielina
Petr
P
Kudela
Milan
M
Lindqvist
Pelle G
PG
D000026:Abortion, Habitual / Q000453:epidemiology; D000037:Abruptio Placentae / Q000453:epidemiology / Q000235:genetics*; D020016:Activated Protein C Resistance / Q000453:epidemiology / Q000235:genetics; D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics; D018570:Risk Assessment; D019851:Thrombophilia / Q000453:epidemiology / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)