Iron-catalyzed alkylation of alkenyl Grignard reagents.
The first iron-catalyzed cross-coupling reaction between alkenyl Grignard reagents and n- or s-alkyl bromides is described. The reaction is stereoselective and takes place in the presence of 5 mol % of [Fe(acac)3/TMEDA/HMTA] (1:2:1) under very mild conditions (THF, 0 degrees C, 45 min).
Cahiez
Gérard
G
Laboratoire de Synthèse Organique Sélective et de Chimie Organométallique (SOSCO), UMR 8123 CNRS-UCP-ESCOM, 5 Mail Gay-Lussac, Neuville/Oise, F-95031 Cergy-Pontoise Cedex, France. gerard.cahiez@u-cergy.fr
Duplais
Christophe
C
Moyeux
Alban
A