title: Gold(I)-catalyzed cascade cyclization reaction: highly regio- and diastereoselective intermolecular addition of water and alcohols to epoxy alkynes.
abstract: We have developed a novel access to ketal skeletons through a highly regio- and diastereoselective intermolecular addition of water and alcohols to alkynyl epoxides catalyzed by gold(I). This procedure involves a domino three-membered ring-opening, 6-exo-cycloisomerization, and subsequent intra- or intermolecular nucleophilic addition to a double-bond sequence.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, China 200032.
authors.forename: Lun-Zhi
authors.initials: LZ
authors.lastname: Dai
authors.forename: Ming-Juan
authors.initials: MJ
authors.lastname: Qi
authors.forename: Yong-Ling
authors.initials: YL
authors.lastname: Shi
authors.forename: Xu-Guang
authors.initials: XG
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Shi