Anti-16-kilodalton mycobacterial protein immunoglobulin m levels in healthy but purified protein derivative-reactive children decrease after chemoprophylaxis.
Serum responses against Mycobacterium tuberculosis HSP16 were determined for children with tuberculosis (TB) and for healthy purified protein derivative (PPD)-positive and PPD-negative children. Immunoglobulin G (IgG) and IgM responses were higher for TB patients than for other groups. After chemotherapy, IgM and IgG responses decreased for TB patients and PPD-positive subjects. Monitoring of anti-M. tuberculosis HSP16 responses could assist in the management of pediatric TB.
Sireci
Guido
G
Dipartimento di Biopatologia e Metodologie Biomediche, Università degli Studi di Palermo, Corso Tukory 211, 90100 Palermo, Italy. sireci@unipa.it
Dieli
Francesco
F
Di Liberto
Diana
D
Buccheri
Simona
S
La Manna
Marco Pio
MP
Scarpa
Francesco
F
Macaluso
Pasquale
P
Romano
Amelia
A
Titone
Lucina
L
Di Carlo
Paola
P
Singh
Mahavir
M
Ivanyi
Jurayi
J
Salerno
Alfredo
A
D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000276:immunology*; D018833:Chaperonins / Q000276:immunology*; D018890:Chemoprevention; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000097:blood / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology*; D014376:Tuberculosis / Q000097:blood / Q000276:immunology / Q000517:prevention & control*
D000995:Antitubercular Agents; D001426:Bacterial Proteins; C431133:Hsp16.3 protein, Mycobacterium tuberculosis; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014373:Tuberculin; D018833:Chaperonins