Innate pathogen recognition in the kidney: toll-like receptors, NOD-like receptors, and RIG-like helicases.
How do infections trigger or aggravate renal pathology? The discovery of the toll-like receptors, and more recently, the retinoic-acid-inducible protein-like helicases and the nucleotide-binding oligomerization domain-like receptors may offer new concepts to answer this question. Common pathogen-associated molecules are recognized by these receptors in several cellular compartments of immune cells and non-immune cells inside the kidney. This article summarizes ligand-receptor interactions and their known or potential significance in kidney diseases.
Anders
H-J
HJ
Department of Nephrology, Medical Policlinic, University of Munich, Munich, Germany. hjanders@med.uni-muenchen.de
D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007674:Kidney Diseases / Q000276:immunology* / Q000503:physiopathology; D053472:Nod Signaling Adaptor Proteins / Q000502:physiology; D020365:RNA Helicases / Q000502:physiology; D051193:Toll-Like Receptors / Q000502:physiology
D053472:Nod Signaling Adaptor Proteins; D051193:Toll-Like Receptors; D020365:RNA Helicases