[Investigation of organophosphorous insecticides residue in Chinese crude drugs].
OBJECTIVE
To study eleven organophosphorus insecticides residuals in four kinds of Chinese crude drugs.


METHODS
The organophosphorus insecticides were extracted with dichloromethane and cleaned-up with a mixture of Celite 545-activated carbon. The extracts were analyzed by gas chromatography equipped with a flame photometric detector (FPD).


RESULTS
Analysis of fortified Chinese crude drug showed that the average recoveries ranged from 77.5% -112.3% at three different levels, the RSDs were below 10% (n = 4). Trace organophosphorous pesticide residues were found in samples of Rhizoma Atractylodis Macrocephalae and Flos Chrysanthemi.


CONCLUSIONS
A method was established for determination multi-residues in Rhizma Atractylodis Macrocephalae, Radix Curcumae, Bulbus Fritillariae Thunbergii and Flos Chrysanthemi. It provides a method for the risk assessment of organophosphorous pesticide in Chinese crude drugs.
Wu
Jia-Lun
JL
Institute of Insecticide and Environmental Toxicology, Huajiachi Campus, Zhejiang University, Hangzhou 310029, China. jlwu@zju.edu.cn
Zhan
Xiu-Ping
XP
Zou
Yao-Hua
YH
Chen
Shi-Fei
SF
Lu
Guang-Zhao
GZ
Lai
Fu-Gen
FG
D031174:Atractylodes / Q000737:chemistry; D002849:Chromatography, Gas; D031202:Chrysanthemum / Q000737:chemistry; D030024:Curcuma / Q000737:chemistry; D004340:Drug Contamination; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D031410:Fritillaria / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000032:analysis*; D010573:Pesticide Residues / Q000032:analysis*; D010946:Plants, Medicinal / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D009943:Organophosphorus Compounds; D010573:Pesticide Residues