Decreased thiamine and magnesium levels in the potentiation of the neurotoxicity of lead in occupational lead exposure.
The relationship between blood lead (Pb) and serum levels of calcium and of neural nutrients such as thiamine and magnesium (Mg) has been determined in a Nigerian population that is occupationally exposed to Pb. Forty-seven male Pb workers were recruited as test subjects and 25 males unexposed to Pb served as controls. The test subjects were classified into three groups, based on severity of exposure to Pb. Blood lead (BPb) and the serum levels of Mg, thiamine, and calcium were determined in both test subjects and controls. The mean blood Pb level was not significantly higher in Pb workers. In contrast, Mg and thiamine levels were significantly decreased (p<0.05; p<0.01, respectively). However, the calcium level was not significantly lower in test subjects than in controls. Also, there was a significant negative correlation between serum thiamine and blood Pb levels (r=-0.50; p<0.01). Furthermore, there was a significant negative correlation between serum calcium and BPb levels (r=-0.41; p<0.01). This study has shown that relatively low BPb levels can enhance Pb absorption and also potentiate Pb neurotoxicity in the presence of decreased serum thiamine and Mg levels.
Anetor
J I
JI
Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Ajose
O A
OA
Adebiyi
J A
JA
Akingbola
T S
TS
Iyanda
A A
AA
Ebesunu
M O
MO
Babalola
O O
OO
Aadeniyi
F A A
FA
D000328:Adult; D002118:Calcium / Q000097:blood; D006801:Humans; D007854:Lead / Q000097:blood* / Q000633:toxicity*; D007855:Lead Poisoning / Q000097:blood / Q000175:diagnosis; D008274:Magnesium / Q000097:blood* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008956:Models, Chemical; D009420:Nervous System / Q000187:drug effects*; D020258:Neurotoxicity Syndromes / Q000209:etiology; D009498:Neurotoxins / Q000494:pharmacology; D009784:Occupational Diseases / Q000209:etiology; D016273:Occupational Exposure; D013831:Thiamine / Q000097:blood*
D009498:Neurotoxins; D007854:Lead; D008274:Magnesium; D002118:Calcium; D013831:Thiamine