The analysis of Neisseria meningitidis proteomes: Reference maps and their applications.
Neisseria meningitidis is an encapsulated Gram-negative bacterium responsible for significant morbidity and mortality worldwide. The availability of meningococcal genome sequences in combination with the rapid growth of proteomic techniques and other high-throughput methods, provided new approaches to the analysis of bacterial system biology. This review considers the meningococcal reference maps so far published as a starting point aimed to elucidate bacterial physiology and pathogenicity, paying particular attention to proteins with potential vaccine and diagnostic applications.
Bernardini
Giulia
G
Dipartimento di Biologia Molecolare, via Fiorentina 1, Università degli Studi di Siena, Siena, Italy.
Braconi
Daniela
D
Santucci
Annalisa
A
D001426:Bacterial Proteins / Q000378:metabolism*; D001428:Bacterial Vaccines; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D016920:Meningitis, Bacterial / Q000453:epidemiology / Q000378:metabolism; D009345:Neisseria meningitidis / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D020543:Proteome; D012333:RNA, Messenger / Q000235:genetics; D014774:Virulence
D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D020543:Proteome; D012333:RNA, Messenger