title: Methods of evaluating the effect of pharmacological drugs on aging and life span in mice.
abstract: The methodology of testing anti-aging drugs in laboratory mice is presented. It includes the selection of mouse strain, sex, age at start of treatment, housing conditions, design of the long-term study, some noninvasive methods of assessment, pathology examination, and statistical treatment of the results.
authors.affiliation: Department of Carcinogenis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Anisimov
authors.forename: Irina G
authors.initials: IG
authors.lastname: Popovich
authors.forename: Mark A
authors.initials: MA
authors.lastname: Zabezhinski
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D004353:Drug Evaluation, Preclinical; D006801:Humans; D051379:Mice; D008954:Models, Biological