[Autoantibodies and autoimmunity in simian immunodeficiency virus-infected monkeys].
OBJECTIVE
To study the relationship between simian acquired immunodeficiency syndromn (SAIDS) and autoimmunity in simian immunodeficiency virus (SIV)-infected monkeys.


METHODS
Indirect immunofluorescence assays were performed to detect plasma or serum autoantibodies in SIV-infected monkeys. The heart, liver, spleen, lung, kidney, and lymph node of BALB/c mice, a strain of endothelial cell ECV304, and granulocytes were used as target antigens. These results were compared with HE stained slides of SIV-infected monkeys.


RESULTS
The levels of various autoantibodies, including anti-lymphocyte autoantibodies, anti-endothelial cell autoantibodies, and anti-granulocyte antibodies, increased after SIV infection in monkeys. Moreover, pathological examinations showed injuries in the lymphoid tissue and vascular pathological changes in cerebral cortex, submucosa of gastrointestinal tract, interstitial capillaries of myocardium, nephron of the kidney, and sinusoid cell of liver.


CONCLUSIONS
The increased autoantibodies and the pathological changes of tissues and organs confirm the existence of autoimmunity in SIV-infected monkeys.
Lu
Yao-zeng
YZ
Institute of Tropical Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China. lyz_wxx@163.com
Wu
Xiao-xian
XX
Fu
Lin-chun
LC
Luo
Hong-mei
HM
Chen
Song
S
Guo
Wei-zhong
WZ
Deng
Wen-di
WD
Zhou
Ying-yun
YY
Lai
Chun-hui
CH
D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D042783:Endothelial Cells / Q000276:immunology; D006098:Granulocytes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology; D015302:Simian Immunodeficiency Virus
D001323:Autoantibodies