Tying the knot: making of lasso peptides.
In this issue of Chemistry & Biology, Duquesne and colleagues [1] describe the biosynthetic machinery of microcin J25, an antibacterial peptide that adopts an exceptional three-dimensional structure resembling a knot. The dedicated enzymes, McjB and McjC, were identified and employed to produce this modification in vitro.
Bierbaum
Gabriele
G
Institute for Medical Microbiology, Immunology and Parasitology, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.
Jansen
Andrea
A
D000595:Amino Acid Sequence; D001430:Bacteriocins / Q000737:chemistry*; D008969:Molecular Sequence Data; D011487:Protein Conformation
D001430:Bacteriocins; C020411:microcin