title: [Expression and significance of DNA topoisomerase I (topo I) in small cell lung cancer].
abstract: OBJECTIVE
  To investigate the expression and its significance of DNA topoisomerase I (Topo I) in small cell lung cancer (SCLC).
  
  
  METHODS
  Topo I expression was detected by immunohistochemical S-P technique on 50 cases of SCLC and 12 cases of normal lung tissues.
  
  
  RESULTS
  The total positive rate of Topo I in normal lung tissue was 25.0% (3/12) and 78.0% (39/50) in SCLC. The expression of Topo I does not correlate with age, gender, smoking, tumor size and tumor site (P > 0.05), but significantly correlated with lymph node metastasis and clinical stage (P <0.05).
  
  
  CONCLUSIONS
  High Topo I expression is a rationale indication of Topo I inhibitor treatment of malignancies. It should be possible to predict anti-tumor drug sensitivity by assessment of Topo I expression and help to improve the therapeutic efficacy for cancer patients.
authors.affiliation: Department of Internal Medecine, Shandong Tumor Hospital, Jinan 250117, China. guoqisen@csco.org.cn
authors.forename: Qi-Sen
authors.initials: QS
authors.lastname: Guo
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Liu
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Yu
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Wang
authors.forename: Wei-Xia
authors.initials: WX
authors.lastname: Zhong
authors.forename: Xiu-Ju
authors.initials: XJ
authors.lastname: Liu
mesh_terms: D018288:Carcinoma, Small Cell / Q000201:enzymology* / Q000473:pathology; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008175:Lung Neoplasms / Q000201:enzymology* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D004264:DNA Topoisomerases, Type I