[Study on genetic diversity of genes encoding main adhesins among nontypeable Haemophilus influenzae strains isolated from children in Poland].
The study was based on hypothesis that in the nontypeable population of H. influenzae strains isolated from children there are some genetically predisposed to induce symptomatic infection in children and that they might be divided into different groups depending on profiles of genes encoding main adhesins synthesis. The work aimed at analysis of distribution of genes encoding adhesins and evaluation of domination possibility of some strains representing particular adhesins genes profiles among NTHi population. Results of the study revealed that among population of NTHi strains, distribution of genes encoding main adhesins are differing. Among children, NTHi strains harbouring genes encoding HA and HMW1/HMW2 adhesins were more prevalent in healthy children and in children with symptomatic infections, respectively. Analysis of strains harbouring main adhesins profiles might be a useful screening method in monitoring strains circulating among children, in order to determine the most invasive NTHi strains.
Augustynowicz
Ewa
E
Zakład Badania Surowic i Szczepionek PZH w Warszawie.
Szenborn
Leszek
L
Samet
Alfred
A
Banyś
Dorota
D
Sledzińska
Anna
A
Gzyl
Anna
A
Rybak
Bartosz
B
Nowaczek
Aneta
A
Slusarczyk
Janusz
J
D018829:Adhesins, Bacterial / Q000235:genetics*; D000328:Adult; D000368:Aged; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques; D002648:Child; D002675:Child, Preschool; D004251:DNA Transposable Elements; D036781:Fimbriae Proteins; D005798:Genes, Bacterial / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006192:Haemophilus Infections / Q000382:microbiology; D006193:Haemophilus influenzae / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D008875:Middle Aged; D010033:Otitis Media / Q000382:microbiology*; D010034:Otitis Media with Effusion / Q000382:microbiology; D011044:Poland; D014774:Virulence
D018829:Adhesins, Bacterial; D001425:Bacterial Outer Membrane Proteins; D004251:DNA Transposable Elements; C090992:HifA protein, Haemophilus influenzae; C090994:HifC protein, Haemophilus influenzae; D036781:Fimbriae Proteins