title: Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial.
abstract: BACKGROUND
  Medicine usage in Parkinson's disease patients is often imperfect, in particular irregular timing of medication. The effect of informing Parkinson's disease patients about the continuous dopaminergic hypothesis (to encourage regular medicine intake) on medication adherence and motor control was tested.
  
  
  METHODS
  Patients were randomised either to the active group (receiving the intervention) or control group (no extra information). Antiparkinson medicine usage was monitored for 3 months before and after the intervention using electronic pill bottles which record the date and time of opening (MEMS, Aardex, Switzerland) and data used to calculate the percentage of doses taken at correct time intervals.
  
  
  RESULTS
  43 patients (52%) were randomised to active counselling, and 40 (48%) were controls (standard management). The intervention effect (difference in timing adherence pre- to post-intervention between the 2 groups) was 13.4% (CI 5.1 to 21.7), p = 0.002. Parkinson motor scores did not change significantly (active group 0.1, CI -3.4 to 3.7) versus controls (4.5, CI 1.6 to 7.1), p = 0.06.
  
  
  CONCLUSIONS
  Timing adherence, but not motor scores, improves by providing patients with extra information. Therapy timing is of potential importance in Parkinson's disease management.
  
  
  BACKGROUND
  NCT00361205.
authors.affiliation: Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK. Katherine.Grosset@gp46081.glasgow-hb.scot.nhs.uk <Katherine.Grosset@gp46081.glasgow-hb.scot.nhs.uk>
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Grosset
authors.forename: Donald G
authors.initials: DG
authors.lastname: Grosset
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy*; D010349:Patient Compliance; D010353:Patient Education as Topic / Q000379:methods*; D012646:Self Administration / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents