Expression of a dendritic cell maturation marker CD83 on tumor cells from lung cancer patients and several human tumor cell lines: is there a biological meaning behind it?
The present paper shows, for the first time, the membrane expression of the dendritic cell maturation marker CD83 on tumor cells from lung cancer patients. CD83 was also detected on freshly cultured fibroblast-like cells from these tissues and on several adherent human tumor cell lines (lung adenocarcinomas P9, A459 and A549, melanomas A375 and C81-61, breast adenocarcinomas SKBR-3 and MCF-7 and colon carcinoma AR42-J), but not in the non-adherent MOT leukemia cell line. CD83 may have immunosuppressive properties and its expression by cancer cells could have a role in facilitating tumor growth.
Baleeiro
R B
RB
Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Av Prof. Lineu Prestes 1730, Cidade Universitária, CEP 05508-000, São Paulo, SP, Brazil.
Bergami-Santos
P C
PC
Tomiyoshi
M Y
MY
Gross
J L
JL
Haddad
F
F
Pinto
C A L
CA
Soares
F A
FA
Younes
R N
RN
Barbuto
J A M
JA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D045744:Cell Line, Tumor; D003713:Dendritic Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D008875:Middle Aged; D000097802:CD83 Antigen
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D000097802:CD83 Antigen