title: Permanent prostate brachytherapy for Japanese men: results from initial 100 patients with prostate cancer.
abstract: OBJECTIVE
  To evaluate the initial results of brachytherapy for prostate cancer with permanent iodine-125 implant in Japan.
  
  
  METHODS
  The results obtained with brachytherapy in the initial 100 Japanese patients treated at Nagano Municipal Hospital were reviewed. Patients with a prostate-specific antigen (PSA) level of less than 10 ng/mL and a Gleason's scores of 5, 6, 3 + 4 were classified as having a low risk of recurrence. Patients with a PSA level of 10-20 ng/mL and/or a Gleason's score of 4 + 3 were classified as having an intermediate risk for recurrence. Seventy-eight of the low-risk patients and 19 of the intermediate-risk patients were treated by seed implants alone, or seed implants combined with preceding external radiation, respectively. A total of 53 patients received neoadjuvant hormone therapy. The efficacy and morbidity of brachytherapy were investigated using the serum PSA, International Prostate Symptom Score, quality of life score and uroflowmetry data.
  
  
  RESULTS
  The average V100 and D90 obtained by post-implant dosimetry was 94.3 and 113.7%, respectively. Serum PSA decreased gradually after treatment, although it had still not reached a nadir after 1 year. There was little difference of the PSA level between the patients with and without neoadjuvant hormone therapy even at 1 year after seed implantation. There were no PSA biochemical failure or clinical recurrence during the follow-up period. Voiding symptoms worsened until 3 months after treatment, and then gradually improved. Acute urinary retention occurred transiently in one patient (1%). Rectal bleeding and severe diarrhea did not occur.
  
  
  CONCLUSIONS
  Brachytherapy is a feasible and effective option for the treatment of prostate cancer in Japanese men. Brachytherapy may have a different effect in Japanese patients with respect to voiding symptoms. Urinary retention was rare, but voiding symptoms were persistent in Japanese patients. Neoadjuvant hormone therapy deserves investigation to determine whether it can achieve better results, especially in patients with an intermediate risk.
authors.affiliation: Department of Urology, Nagano Municipal Hospital, 1333-1 Tomitake, Nagano, Nagano 381-8551, Japan. okaneya@hospital.nagano.nagano.jp
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Okaneya
authors.forename: Shuji
authors.initials: S
authors.lastname: Nishizawa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nakayama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kamigaito
authors.forename: Iwao
authors.initials: I
authors.lastname: Hashida
authors.forename: Noriko
authors.initials: N
authors.lastname: Hosaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D007564:Japan; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes