title: Undetected hepatocellular carcinoma in patients undergoing liver transplantation: is associated with favorable outcome.
abstract: OBJECTIVE
  The aim of the study was to define the clinical characteristics and outcome of patients found to have undetected hepatocellular carcinomas (HCC) at liver transplantation. Patients who underwent liver transplantation and were unexpectedly found to have a HCC despite prior workup showing normal alpha-fetoprotein levels and/or no visible radiological lesion were defined as having an undetected HCC.
  
  
  METHODS
  Thirty-two of these patients had a histological diagnosis of HCC in the explanted liver. Undetected HCC was defined as a carcinoma found only on pathological evaluation of the explanted liver, with a pre-OLT workup showing a normal serum alpha-fetoprotein (AFP) level (<20 ng/mL) and/or no suspicious lesion on preoperative radiological evaluation.
  
  
  RESULTS
  Nine patients had a tumor that met the criteria for an undetected HCC. The most common cause for transplantation was cryptogenic cirrhosis (44.4%). Tumor size was 2 cm or less in all patients, vascular invasion was detected in 11.1% of the patients, and tumor, node, metastasis (TNM) classification was stage I in 77.8%. Eight patients (88.9%) remained alive at the cessation of the analysis with a mean follow-up of 60 +/- 30.4 months. There was no tumor recurrence in any patient. Statistical analysis showed significant differences between undetected and detected HCCs when causes of pretransplantation liver disease, peak AFP level, tumor size, number of tumors, presence of vascular invasion or pathological differentiation were compared. Undetected HCCs were associated with a better survival rate after liver transplantation (p = 0.008).
  
  
  CONCLUSIONS
  Patients with undetected HCCs at OLT have a favorable outcome with tumor-free survival. Most patients had small, early-stage HCCs, but the possibility of finding tumors greater than 2 cm, multifocal lesions, and vascular invasion exist despite thorough investigation. An exhaustive histopathological search of the explant for malignancy will allow for greater accuracy in prognosis.
authors.affiliation: Queensland Liver Transplant Service, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: Taizen
authors.initials: T
authors.lastname: Urahashi
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Lynch
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Kim
authors.forename: Glenda A
authors.initials: GA
authors.lastname: Balderson
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Fawcett
authors.forename: Darryl H
authors.initials: DH
authors.lastname: Crawford
authors.forename: Russell W
authors.initials: RW
authors.lastname: Strong
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000601:surgery*; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis*; D016031:Liver Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D016896:Treatment Outcome