Polarization of B effector cells in Sjögren's syndrome.
Analysis of salivary glands of patients with primary Sjögren's syndrome has yielded conflicting results with respect to T helper (Th)1/Th2 polarization. This balance might parallel the progress of the local lesions. B-cells are now taking center stage in this disease. They can also be primed to differentiate into two cytokine-production pathways, dubbed B effector (Be) 1 and Be2 cells. This is discussed in the light of our recent finding that Be1 accompany Th1, while Be2 accompany in the tissue lesions.
Daridon
Capucine
C
Laboratory of Immunology, Brest University Medical School Hospital, Brest, France.
Guerrier
Thomas
T
Devauchelle
Valérie
V
Saraux
Alain
A
Pers
Jacques-Olivier
JO
Youinou
Pierre
P
D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D012469:Salivary Glands / Q000276:immunology; D012859:Sjogren's Syndrome / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology