Loudness dependence of auditory evoked potentials is not associated with polymorphisms or haplotypes in the serotonin transporter gene in a community-based sample of German healthy volunteers.
Three previous studies found an association between the loudness dependence (LD) of the auditory evoked potential N1/P2 component, an indicator of central serotonergic neurotransmission, and a functional variation in the promoter region of the 5-hydroxytryptamine transporter (5-HTT) gene (rs4795541 Ins/Del). The results of these three studies were contradictory and possibly biased by the recruitment methods used. We therefore aimed to re-investigate this association (rs4795541) using a community-based sample randomly selected from the general population and to extend the analysis to four further putative variations in this gene (rs3783594, rs3794808, rs140701, rs6354). In this carefully recruited sample, genotypes or haplotypes under investigation were not associated with LD. We speculate that the LD endophenotype depends more on genetic variations in components of the serotonergic system controlling release than on those controlling the uptake mechanism.
Juckel
Georg
G
Department of Psychiatry, Ruhr-University Bochum, Germany. georg.juckel@wkp-lwl.org
Hegerl
Ulrich
U
Giegling
Ina
I
Mavrogiorgou
Paraskevi
P
Gallinat
Jürgen
J
Augustin
Holger
H
Mulert
Christoph
C
Pogarell
Oliver
O
Rujescu
Dan
D
D001307:Auditory Perception; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D015870:Gene Expression / Q000235:genetics; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes; D006304:Health Status; D006311:Hearing Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008144:Loudness Perception; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012111:Residence Characteristics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013001:Somatoform Disorders / Q000175:diagnosis / Q000453:epidemiology; D009435:Synaptic Transmission / Q000502:physiology*
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins