Antimicrobial resistance of Vibrio cholerae O1 serotype Ogawa isolated in Manhiça District Hospital, southern Mozambique.
OBJECTIVE
To describe the antimicrobial susceptibility profile of isolated Vibrio cholerae O1 serotype Ogawa recovered from patients admitted to the cholera facility in the Manhiça District Hospital (MDH), Mozambique.


METHODS
Rectal swabs were collected from patients with complaints symptomatic of cholera admitted to the MDH cholera facility. Samples were processed for V. cholerae isolation at the Centro de Investigação em Saúde da Manhiça (CISM) and identified by biochemical reaction. Serotypes were determined by slide-agglutination antisera. Susceptibilities were determined by disc diffusion.


RESULTS
Seventy-seven isolates were examined for their resistance profile. High incidences of antimicrobial resistance were found for chloramphenicol (57.9%), co-trimoxazole (96.6%) and tetracycline (97.3%). Quinolone resistance remained low (4.2%).


CONCLUSIONS
Although V. cholerae infections in Africa do not usually require antimicrobial treatment, strains in rural Mozambique show high incidences of resistance to readily available drugs. When appropriate, quinolones or third-generation cephalosporins can be used as treatment options.
Mandomando
Inácio
I
Centro de Investigação em Saúde da Manhiça (CISM), Maputo, Mozambique. inacio.mandomando@manhica.net
Espasa
Mateu
M
Vallès
Xavier
X
Sacarlal
Jahit
J
Sigaúque
Betuel
B
Ruiz
Joaquim
J
Alonso
Pedro
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002771:Cholera / Q000382:microbiology*; D003627:Data Interpretation, Statistical; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009073:Mozambique; D012007:Rectum / Q000382:microbiology; D012424:Rural Population; D041241:Vibrio cholerae O1 / Q000187:drug effects*
D000900:Anti-Bacterial Agents