[Studies on protective effects of Niuhuang Shangqing pills on cerebral ischemia].
OBJECTIVE
To discuss the protective effect of Niuhuang Shangqing pills (NSP) on the experimental cerebral ischemia and the influence of blood rheology in animals.


METHODS
Using the middle cerebral artery occlusion (MCAO), bilateral common carotid artery ligation and lipopolysaccharide (LPS) in combination with carrogeenin (Ca)-induced stagnation of blood model rats, we investigated the influence of NSP on the physical sign indexes, brain infarct size and the water content, the content of lactate(LD), glutathione peroxidase (GPx), catalase (CAT), malondialdehyde (MDA) and the blood rheology.


RESULTS
The 3.00, 1.50 g x kg(-1) dosage groups of NSP decreased the neurosigns indexes, significantly reduced the brain infarct areas in MCAO rats, decreased the brain water content, increased the activities of GPx and CAT, decreased the content of LD and MDA in bilateral common carotid artery ligation rats. They improved the blood rheology in lipopolysaccharide (LPS) in combination with carrogeenin (Ca)-induced stagnation of blood model rats.


CONCLUSIONS
NSP has the function of protective effect on experimental experimental cerebral ischemia.
Zhang
Lei
L
Institute of Chinese Materia Medica, China Academy of Chinese Medicial Sciences, Beijing 100700, China.
Zhao
Yong
Y
Zhang
Lei
L
Liu
Ting
T
Li
Chun-Ying
CY
Jin
Ran
R
Zhou
Lei
L
Li
Jian-Rong
JR
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D020520:Brain Infarction / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D002545:Brain Ischemia / Q000097:blood / Q000150:complications / Q000517:prevention & control*; D002374:Catalase / Q000378:metabolism; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; C530450:niuhuang shangqing; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase