Lung deposition of radiolabeled tiotropium in healthy subjects and patients with chronic obstructive pulmonary disease.
Lung deposition of 18 microg tiotropium administered via a dry-powder inhaler was investigated in 5 healthy subjects and patients with mild (n = 4), moderate (n = 6), and severe (n = 5) chronic obstructive pulmonary disease after 14 days of treatment with 18 microg tiotropium. On day 15, subjects inhaled 2 capsules of radiolabeled tiotropium, and lung deposition was assessed using gamma scintigraphy. Repeated plasma and urine collections were performed on days 14 and 15. Mean delivered dose from the dry-powder inhaler was 45.1%. Mean lung deposition relative to the delivered dose was 42% (19%, relative to nominal dose) with low intersubject variability (20%). Mean extrathoracic deposition was 57.5% (25.8%, relative to nominal dose). There were no significant differences in deposition among the subgroups. No significant correlation between individual tiotropium deposition and lung function was observed. These results suggest that all stages of chronic obstructive pulmonary disease may gain full therapeutic benefit from the drug.
Brand
Peter
P
Inamed Research GmbH & Co KG, Institute for Aerosol Medicine, Robert-Koch-Allee 29, D-82131 Gauting, Germany. brand@inamed.de
Meyer
Thomas
T
Weuthen
Thomas
T
Timmer
Wolfgang
W
Berkel
Erhard
E
Wallenstein
Gudrun
G
Scheuch
Gerhard
G
D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism* / Q000503:physiopathology; D019275:Radiopharmaceuticals; D012602:Scopolamine Derivatives / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D013670:Sodium Pertechnetate Tc 99m; D000069447:Tiotropium Bromide
D001993:Bronchodilator Agents; D019275:Radiopharmaceuticals; D012602:Scopolamine Derivatives; D013670:Sodium Pertechnetate Tc 99m; D000069447:Tiotropium Bromide