[Nitrofurantoin-induced lung disease: about two cases].
BACKGROUND
Nitrofurantoin is commonly used in the treatment of urinary tract infection and may cause a potential severe complication: interstitial lung diseases.


METHODS
A 78-year-old and an 87-year-old woman treated with nitrofurantoin since respectively 10 months and 6 years developed cough and dyspnea. Antibiotics were ineffective and interstitial lung disease was found. Nitrofurantoin's stopping allowed a clinical and radiological improvement.


CONCLUSIONS
A good medical supervision is important when nitrofurantoin is prescribed for a long time. The treatment has to be stopped when respiratory symptoms appear to allow an improvement of the symptoms.
Mrozek
N
N
Service de médecine interne, CHU Gabriel-Montpied, 58, rue Montalembert, B.P. 69, 63003 Clermont-Ferrand cedex 01, France.
Delèvaux
I
I
Legendre
M
M
André
M
M
Trouillier
S
S
Voinchet
H
H
Aumaitre
O
O
D000368:Aged; D000369:Aged, 80 and over; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D003371:Cough / Q000139:chemically induced; D004417:Dyspnea / Q000139:chemically induced; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000503:physiopathology; D008448:Maximal Expiratory Flow Rate / Q000187:drug effects; D009582:Nitrofurantoin / Q000009:adverse effects*; D014109:Total Lung Capacity / Q000187:drug effects; D014797:Vital Capacity / Q000187:drug effects
D000892:Anti-Infective Agents, Urinary; D009582:Nitrofurantoin