title: Testicular juvenile granulosa cell tumor in a newborn: case report and review of the literature.
abstract: Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia. This report describes a juvenile granulosa cell tumor arising in the testis of a neonate. Chromosome analysis of the tumor showed a normal male karyotype 46 XY. Histopathology and immunohistochemical studies revealed the occurrence of 2 well-differentiated epithelial-like and smooth muscle-like components in the neoplasm. The morphologic clues leading to the correct diagnosis of juvenile granulosa cell tumor and the possible histogenesis are briefly discussed.
authors.affiliation: University of Maryland Medical System, Department of Pathology NBW48, Department of Surgery and Hospital for Children, Baltimore, MD 21201, USA. balexiev@umm.edu
authors.forename: Borislav A
authors.initials: BA
authors.lastname: Alexiev
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Alaish
authors.forename: Chen-Chih
authors.initials: CC
authors.lastname: Sun
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D006106:Granulosa Cell Tumor / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007265:Inhibins / Q000235:genetics / Q000378:metabolism; D008297:Male; D012729:Sex Chromosome Aberrations; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D013737:Testis / Q000378:metabolism / Q000473:pathology; D014746:Vimentin / Q000235:genetics / Q000378:metabolism
chemical_list: D014746:Vimentin; D007265:Inhibins