Antagonistic drug combinations that select against drug resistance: from bacteria to cancer.
Any drug selects for drug resistance. But super-antagonistic drug combinations can select for drug sensitivity. This has important application not only for antibacterial therapy but also for cancer therapy: to control cancer with lesser side effects and to eliminate drug-resistant cancer cells, while sparing sensitive normal cells.
Blagosklonny
Mikhail V
MV
Ordway Research Institute, Cancer Institute, 150 New Scotland Avenue, Albany, New York 12208, USA. blagosklonny@oncotarget.com
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004336:Drug Antagonism; D019008:Drug Resistance, Neoplasm; D004359:Drug Therapy, Combination; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D000900:Anti-Bacterial Agents