title: A new approach for 'deep salvage' trials in advanced HIV infection.
abstract: One of the most difficult problems in HIV care today is the management of individuals infected with multidrug-resistant viruses. Well-controlled, carefully designed clinical trials have recently resulted in the approval of several new antiviral agents for the treatment of drug-resistant HIV. The design of these trials has come at the cost of the predictable emergence of drug-resistant viruses among individuals randomly assigned to receive a suboptimal revised treatment regimen. We propose here a different approach to the evaluation of drug efficacy in individuals harbouring multidrug-resistant HIV.
authors.affiliation: Center for AIDS Research, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Lederman
authors.forename: Veronica
authors.initials: V
authors.lastname: Miller
authors.forename: Ian
authors.initials: I
authors.lastname: Weller
authors.forename: Steven G
authors.initials: SG
authors.lastname: Deeks
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods*; D024921:Drug Resistance, Multiple, Viral; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D012107:Research Design; D016879:Salvage Therapy / Q000379:methods*
chemical_list: D019380:Anti-HIV Agents