title: [Autoantibodies and autoimmunity in simian immunodeficiency virus-infected monkeys].
abstract: OBJECTIVE
  To study the relationship between simian acquired immunodeficiency syndromn (SAIDS) and autoimmunity in simian immunodeficiency virus (SIV)-infected monkeys.
  
  
  METHODS
  Indirect immunofluorescence assays were performed to detect plasma or serum autoantibodies in SIV-infected monkeys. The heart, liver, spleen, lung, kidney, and lymph node of BALB/c mice, a strain of endothelial cell ECV304, and granulocytes were used as target antigens. These results were compared with HE stained slides of SIV-infected monkeys.
  
  
  RESULTS
  The levels of various autoantibodies, including anti-lymphocyte autoantibodies, anti-endothelial cell autoantibodies, and anti-granulocyte antibodies, increased after SIV infection in monkeys. Moreover, pathological examinations showed injuries in the lymphoid tissue and vascular pathological changes in cerebral cortex, submucosa of gastrointestinal tract, interstitial capillaries of myocardium, nephron of the kidney, and sinusoid cell of liver.
  
  
  CONCLUSIONS
  The increased autoantibodies and the pathological changes of tissues and organs confirm the existence of autoimmunity in SIV-infected monkeys.
authors.affiliation: Institute of Tropical Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China. lyz_wxx@163.com
authors.forename: Yao-zeng
authors.initials: YZ
authors.lastname: Lu
authors.forename: Xiao-xian
authors.initials: XX
authors.lastname: Wu
authors.forename: Lin-chun
authors.initials: LC
authors.lastname: Fu
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Luo
authors.forename: Song
authors.initials: S
authors.lastname: Chen
authors.forename: Wei-zhong
authors.initials: WZ
authors.lastname: Guo
authors.forename: Wen-di
authors.initials: WD
authors.lastname: Deng
authors.forename: Ying-yun
authors.initials: YY
authors.lastname: Zhou
authors.forename: Chun-hui
authors.initials: CH
authors.lastname: Lai
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D042783:Endothelial Cells / Q000276:immunology; D006098:Granulocytes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology; D015302:Simian Immunodeficiency Virus
chemical_list: D001323:Autoantibodies