Mending the bones with natural products.
In this issue, Qiu and colleagues [1] demonstrate in vitro and in vivo activity of a triterpene glycoside from black cohosh. The isolated compound acts as a suppressor of osteoclastogenesis, targeting specifically RANKL, a member of the TNF superfamily.
Sethi
Gautam
G
Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA.
Aggarwal
Bharat B
BB
D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use*; D001847:Bone Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D002455:Cell Division / Q000187:drug effects; D031885:Cimicifuga; D006801:Humans; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects; D053245:RANK Ligand / Q000037:antagonists & inhibitors
D001688:Biological Products; D053245:RANK Ligand; C505688:TNFSF11 protein, human