title: Bone mass of a 113-year-old man.
abstract: Osteoporosis is a common disease that affects elderly people. Aging induces loss of bone density and quality resulting in a progressive incidence of fragility fractures. In this study, we report the bone density of one of the oldest men in the world and of several of his first-degree relatives, as well as a genetic screen of these cases. No fractures have been suffered by any of them, and their bone mineral density (BMD) values in terms of z score were normal or lightly decreased. Neither mutations at the longevity-related gene KLOTHO nor the Gly171Val mutation of LRP5 associated with high bone mass was detected in the two centenarian stepbrothers.
authors.affiliation: Hospital del Mar, Unidad de Recerca en Fisiopatología Osea i Articular, Institut d'Investigació Medica, Universidad Autónoma de Barcelona, 08003, Spain. lmellibovsky@imas.imim.es
authors.forename: Leonardo
authors.initials: L
authors.lastname: Mellibovsky
authors.forename: Mariona
authors.initials: M
authors.lastname: Bustamante
authors.forename: Pau
authors.initials: P
authors.lastname: Lluch
authors.forename: Xavier
authors.initials: X
authors.lastname: Nogues
authors.forename: Daniel
authors.initials: D
authors.lastname: Grinberg
authors.forename: Susana
authors.initials: S
authors.lastname: Balcells
authors.forename: Adolfo
authors.initials: A
authors.lastname: Diez-Perez
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D005260:Female; D005966:Glucuronidase / Q000235:genetics; D006801:Humans; D000090265:Klotho Proteins; D008136:Longevity / Q000235:genetics; D008297:Male
chemical_list: D005966:Glucuronidase; D000090265:Klotho Proteins