Hematopoietic growth factors for hematopoietic stem cell mobilization and expansion.
During inflammation and cytopenia, increased levels of hematopoietic growth factors (HPGFs) induce mobilization and proliferation of hematopoietic stem cells and hematopoietic progenitor cells (HPCs), resulting in spatial and quantitative in vivo expansion of the hematopoietic tissue. Exogenous administration of recombinant HPGFs, particularly granulocyte colony-stimulating factor (G-CSF), is routine for mobilization of stem cells, followed by collection and transplantation of autologous or allogeneic stem cells. In this review, we summarize experience using different HPGFs and HPGF combinations for stem cell mobilization, such as G-CSF, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), stem cell factor (SCF), and others. Preclinical and clinical studies of so-called early- and late-acting HPGFs for ex vivo expansion of HPCs are discussed, also with respect to the unresolved question whether expansion of repopulating stem cells can be achieved in vitro.
Möhle
Robert
R
Department of Medicine II, University of Tübingen, Tübingen, Germany. robert.moehle@med.uni-teubingen.de
Kanz
Lothar
L
D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood / Q000502:physiology / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood / Q000627:therapeutic use; D006402:Hematologic Diseases / Q000188:drug therapy*; D006410:Hematopoiesis; D016298:Hematopoietic Cell Growth Factors / Q000627:therapeutic use*; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D019089:Stem Cell Factor / Q000097:blood / Q000627:therapeutic use
D016298:Hematopoietic Cell Growth Factors; D019089:Stem Cell Factor; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor