Prospects for microbeam radiation therapy of brain tumours in children to reduce neurological sequelae.
Microbeam radiation therapy (MRT), a form of experimental radiosurgery of tumours using multiple parallel, planar, micrometres-wide, synchrotron-generated X-ray beams ('microbeams'), can safely deliver radiation doses to contiguous normal animal tissues that are much higher than the maximum doses tolerated by the same normal tissues of animals or patients from any standard millimetres-wide radiosurgical beam. An array of parallel microbeams, even in doses that cause little damage to radiosensitive developing tissues, for example, the chick chorioallantoic membrane, can inhibit growth or ablate some transplanted malignant tumours in rodents. The cerebella of 100 normal 20 to 38g suckling Sprague-Dawley rat pups and of 13 normal 5 to 12kg weanling Yorkshire piglets were irradiated with an array of parallel, synchrotron-wiggler-generated X-ray microbeams in doses overlapping the MRT-relevant range (about 50-600Gy) using the ID17 wiggler beamline tangential to the 6GeV electron synchrotron ring at the European Synchrotron Radiation Facility in Grenoble, France. Subsequent favourable development of most animals over at least 1 year suggests that MRT might be used to treat children's brain tumours with less risk to the development of the central nervous system than is presently the case when using wider beams.
Laissue
J A
JA
Institut für Pathologie der Universität Bern, Bern, Switzerland. laissue@pathology.unibe.ch
Blattmann
H
H
Wagner
H P
HP
Grotzer
M A
MA
Slatkin
D N
DN
D000818:Animals; D001932:Brain Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009460:Neurologic Examination; D014964:X-Ray Therapy / Q000009:adverse effects / Q000379:methods*