A concise asymmetric synthesis of torcetrapib.
Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.
Guinó
Meritxell
M
Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, United Kingdom.
Phua
Pim Huat
PH
Caille
Jean-Claude
JC
Hii
King Kuok Mimi
KK
D000596:Amino Acids / Q000737:chemistry; D002219:Carbamates / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013997:Time Factors
D000596:Amino Acids; D002219:Carbamates; D011804:Quinolines; C483909:torcetrapib