[IR spectroscopic research on the impact of chemical analogues of autoregulatory d1 factors of microorganisms on structural changes in DNA].
Using IR spectroscopy, we investigated the impact of chemical analogues of autoregulatory d1 factors of microorganisms (methylresorcinol, hexylresorcinol, and tyrosol) on the conformational changes in DNA in films upon altering (decreasing) the relative humidity. We analyzed the appearance/disappearance of characteristic absorption bands of A and B DNA forms and determined D1080/D1224, the ratio between the band intensities of symmetrical and asymmetrical oscillations in their phosphate groups. The data obtained suggest the slowing down of the B-->A structural transition in DNA in the presence of methylresorcinol and its speeding up in the presence of tyrosol. We discuss the mechanisms of this phenomenon in relation to the chemical composition of d1 factors and their biological function.
Davydova
O K
OK
Deriabin
D G
DG
El'-Registan
G I
GI
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004247:DNA / Q000032:analysis / Q000737:chemistry / Q000187:drug effects*; D008297:Male; D008968:Molecular Conformation; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D012118:Resorcinols / Q000737:chemistry / Q000494:pharmacology*; D019265:Spectroscopy, Near-Infrared; D013094:Spermatozoa / Q000737:chemistry
D000975:Antioxidants; D012118:Resorcinols; C011867:4-hydroxyphenylethanol; D004247:DNA; D010626:Phenylethyl Alcohol