Regulating B-cell activation and survival in response to TLR signals.
Following encounters with microbes, cellular activation programs that involve the control of proliferation and survival are initiated in follicular B cells either via the B-cell receptor in a specific antigen-defined manner, or through Toll-like receptors (TLRs) that recognize specific microbial products. This review summarizes and discusses recent findings that shed light on how the nuclear factor kappaB pathway controls and coordinates B-cell division and survival following TLR4 engagement.
Gerondakis
Steve
S
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. geron@wehi.edu.au
Grumont
Raelene J
RJ
Banerjee
Ashish
A
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000201:enzymology / Q000276:immunology*; D002470:Cell Survival; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D016328:NF-kappa B; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
D016328:NF-kappa B; D051193:Toll-Like Receptors