PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics.
Out of 400 virtually designed imidazoline N-oxides, five cyclic nitrones were selected on the basis of PASS prediction as potent nootropics and were evaluated for their biological activities in albino mice. The selected N-alkyl and aryl-substituted nitrones were found to be excellent nootropics. A series of lead compounds acting as cognition enhancers have been provided, which can be further exploited in search of such New Chemical Entities (NCEs).
Marwaha
Alka
A
Department of Applied Chemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India.
Goel
R K
RK
Mahajan
Mohinder P
MP
D000818:Animals; D001522:Behavior, Animal; D015195:Drug Design; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D051379:Mice; D009589:Nitrogen Oxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018697:Nootropic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D009589:Nitrogen Oxides; D018697:Nootropic Agents; C015388:nitrones