What's taking so long? S-phase entry from quiescence versus proliferation.
There is a short window in the mammalian cell cycle during which cells can respond to extracellular cues by withdrawing temporarily from the cell cycle. When these cells re-enter the cell cycle, they require several extra hours in the G1 phase before they replicate their DNA compared with their cycling counterparts. More than 20 years after this initial observation, we still do not understand what is taking so long.
Coller
Hilary A
HA
Department of Molecular Biology, Lewis Thomas Laboratory, Room 140, Princeton University, Princeton, New Jersey 08544-1014, USA. hcoller@princeton.edu
D000818:Animals; D004261:DNA Replication / Q000502:physiology*; D016193:G1 Phase / Q000502:physiology*; D006801:Humans; D016196:S Phase / Q000502:physiology*; D013997:Time Factors