CD8 T cell dysfunction during chronic viral infection.
Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.
Shin
Haina
H
Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
Wherry
E John
EJ
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002908:Chronic Disease; D016207:Cytokines / Q000378:metabolism*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007156:Immunologic Memory; D008216:Lymphocytic Choriomeningitis / Q000276:immunology* / Q000821:virology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology
D016207:Cytokines; D011948:Receptors, Antigen, T-Cell