[Apoptosis. Signaling network and changes of cell ion and water balance].
The review focuses on the shift of the monovalent ion balance, pH, and the membrane potential during apoptosis with respect to the ionic mechanism of apoptotic cell shrinkage. As an introduction the current views on the main signaling network, involved in the induction of apoptosis, i. e. receptor and mitochondrial pathways of caspase cascade activation and a caspase-independent induction of apoptosis are considered. The review summarizes the recent data on alteration of ion transporters and channels of the plasma membrane during apoptosis.
Shirokova
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D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020346:Aquaporins / Q000502:physiology; D020169:Caspases / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes; D007473:Ion Channels / Q000378:metabolism; D017136:Ion Transport / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D015398:Signal Transduction
D020346:Aquaporins; D007473:Ion Channels; D020169:Caspases