Effects of micronized purified flavonoid fraction (Daflon) on pelvic pain in women with laparoscopically diagnosed pelvic congestion syndrome: a randomized crossover trial.
BACKGROUND
We evaluated the effects of daflon, a venomimetic agent that regulates the circulatory tonus of the venous system, on pelvic pain and investigated the role of enlarged veins in the pathophysiology of pelvic congestion syndrome.


METHODS
Twenty women (age 28-35 yrs) with chronic pelvic pain were diagnosed with the syndrome at laparoscopy. They all had prominent broad ligaments and ovarian veins without other pathologies such as endometriosis to explain the etiology of pelvic pain. Ten women were randomized in a fashion to receive 500 mg of Daflon twice/daily for six months, and ten a vitamin pill for placebo effect; they were crossed over for another six months.


RESULTS
At the end of the third month, the frequency and severity of pelvic symptoms began to decrease with daflon compared with the pretreatment and vitamin arm. The mean scores were significantly less at the end of six months, respectively, p < 0.05.


CONCLUSIONS
Pharmacologic enhancement of venous tonus may restore pelvic circulation and relieve pelvic symptomatology.
Simsek
M
M
Department of Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey.
Burak
F
F
Taskin
O
O
D000328:Adult; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D004145:Diosmin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D017699:Pelvic Pain / Q000188:drug therapy*; D010388:Pelvis / Q000098:blood supply* / Q000000981:diagnostic imaging; D016896:Treatment Outcome; D014463:Ultrasonography; D014648:Varicose Veins / Q000000981:diagnostic imaging / Q000188:drug therapy*
D002317:Cardiovascular Agents; D004145:Diosmin