Synthesis, analgesic and anti-inflammatory activity of 4-(2-phenoxyphenyl)semicarbazones.
A series of 4-(2-phenoxyphenyl)semicarbazones was synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds (e. g. 10h, 10i, and 11i) were found to be more potent than the reference drug mefenamic acid in the formalin test. Based on the results of an anti-inflammatory study, 1-(1-(2,5-dimethoxyphenyl)ethylidene)-4-(2-phenoxyphenyl)semicarbazide 11i was the most active compound.
Rineh
Ardeshir
A
Department of Chemistry, University of Guilan, Rasht, Iran.
Mahmoodi
Nosratollah
N
Abdollahi
Mohammad
M
Foroumadi
Alireza
A
Sorkhi
Maedeh
M
Shafiee
Abbas
A
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D012664:Semicarbazones