title: Molecular hybridization: a useful tool in the design of new drug prototypes.
abstract: Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hybrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can result in compounds presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects. So, in this paper, we described several examples of different strategies for drug design, discovery and pharmacomodulation focused on new innovative hybrid compounds presenting analgesic, anti-inflammatory, platelet anti-aggregating, anti-infectious, anticancer, cardio- and neuroactive properties.
authors.affiliation: Instituto de Química, Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara, São Paulo, SP, Brazil.
authors.forename: Cláudio
authors.initials: C
authors.lastname: Viegas-Junior
authors.forename: Amanda
authors.initials: A
authors.lastname: Danuello
authors.forename: Vanderlan
authors.initials: V
authors.lastname: da Silva Bolzani
authors.forename: Eliezer J
authors.initials: EJ
authors.lastname: Barreiro
authors.forename: Carlos Alberto Manssour
authors.initials: CA
authors.lastname: Fraga
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000138:chemical synthesis / Q000494:pharmacology; D015195:Drug Design; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D008024:Ligands
chemical_list: D000700:Analgesics; D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D002317:Cardiovascular Agents; D005343:Fibrinolytic Agents; D007004:Hypoglycemic Agents; D008024:Ligands