Phylogeny of the TRAF/MATH domain.
The TNF-receptor associated factor (TRAF) domain (TD), also known as the meprin and TRAF-C homology (MATH) domain is a fold of seven anti-parallel p-helices that participates in protein-protein interactions. This fold is broadly represented among eukaryotes, where it is found associated with a discrete set of protein-domains. Virtually all protein families encompassing a TRAF/MATH domain seem to be involved in the regulation of protein processing and ubiquitination, strongly suggesting a parallel evolution of the TRAF/MATH domain and certain proteolysis pathways in eukaryotes. The restricted number of living organisms for which we have information of their genetic and protein make-up limits the scope and analysis of the MATH domain in evolution. However, the available information allows us to get a glimpse on the origins, distribution and evolution of the TRAF/MATH domain, which will be overviewed in this chapter.
Zapata
Juan M
JM
Burnham Institute for Medical Research, 10901 N. Torrey Pines Road, La Jolla, California 92037, USA. jzapata@burnham.org
Martínez-García
Vanesa
V
Lefebvre
Sophie
S
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008666:Metalloendopeptidases / Q000737:chemistry* / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D017434:Protein Structure, Tertiary / Q000235:genetics; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000737:chemistry* / Q000235:genetics*
D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D008666:Metalloendopeptidases