Yersinia pestis CO92 delta yopH is a potent live, attenuated plague vaccine.
An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92 delta yopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.
Bubeck
Sarah S
SS
Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA.
Dube
Peter H
PH
D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology* / Q000378:metabolism; D005260:Female; D051379:Mice; D010930:Plague / Q000382:microbiology / Q000517:prevention & control*; D010931:Plague Vaccine / Q000276:immunology* / Q000494:pharmacology; D017027:Protein Tyrosine Phosphatases / Q000276:immunology* / Q000378:metabolism; D014613:Vaccines, Attenuated / Q000276:immunology / Q000494:pharmacology; D015010:Yersinia pestis / Q000276:immunology*
D001425:Bacterial Outer Membrane Proteins; D010931:Plague Vaccine; D014613:Vaccines, Attenuated; D017027:Protein Tyrosine Phosphatases; C067571:yopH protein, Yersinia