title: Nickel(II) thiohydrazide and thiodiamine complexes: synthesis, characterization, antibacterial, antifungal and thermal studies.
abstract: Nickel(II) complexes of type [Ni(L)(2)Cl(2)] and [Ni(L)(2)(OCOCH(3))(2)], where L=N,N-diphenyl-N-thiohydrazide (L(1)) and (N,N-diphenyl-N-thio)-1,3-propanediamine (L(2)), have been synthesized. The thiodiamines coordinate as a bidentate N-S ligand. The synthesized nickel(II) complexes of the thiodiamines were characterized by elemental analysis, IR, mass, electronic and (1)H NMR spectroscopic and TG/DTA studies. Various kinetic and thermodynamic parameters like order of reaction (n), activation energy (E(a)), apparent activation entropy (S(#)) and heat of reaction (DeltaH) have also been carried out for one complex. These complexes were also screened for in vitro antifungal and in vitro antibacterial activities and significant activity have been found.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India. ajaykmishra1@yahoo.com
authors.forename: A K
authors.initials: AK
authors.lastname: Mishra
authors.forename: N K
authors.initials: NK
authors.lastname: Kaushik
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry*; D004055:Differential Thermal Analysis; D004159:Diphenylamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013818:Thermogravimetry; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003959:Diamines; D006834:Hydrazines; D009942:Organometallic Compounds; D009532:Nickel; D004159:Diphenylamine; D013890:Thiourea