Effect of a glucosamine derivative on impact-induced chondrocyte apoptosis in vitro. A preliminary report.
Here, we report that a lipophilic derivative of glucosamine, Glu5, is able to prevent impact-induced chondrocyte death by the putative mechanism of reducing mitochondrial depolarisation following a single impact load in vitro.
Huser
C A M
CA
Comparative Orthopaedics Research Lab, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Davies
M E
ME
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002358:Cartilage, Articular / Q000293:injuries / Q000473:pathology*; D019902:Chondrocytes / Q000473:pathology*; D005944:Glucosamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D006736:Horses; D020287:In Situ Nick-End Labeling; D013314:Stress, Mechanical
D005944:Glucosamine