title: Community coverage of an antimalarial combination of artesunate and amodiaquine in Makamba Province, Burundi, nine months after its introduction.
abstract: BACKGROUND
  In 2003, artesunate-amodiaquine (AS+AQ) was introduced as the new first-line treatment for uncomplicated malaria in Burundi. After confirmed diagnosis, treatment was delivered at subsidized prices in public health centres. Nine months after its implementation a study was carried out to assess whether children below five years of age with uncomplicated malaria were actually receiving AS+AQ.
  
  
  METHODS
  A community-based study was conducted in Makamba province. Randomly selected households containing one or more children under five with reported fever onset within fourteen days before the study date were eligible. Case-management information was collected based on caregiver recall. A case definition of symptomatic malaria from observations of children presenting a confirmed malaria episode on the day of the survey was developed. Based on this definition, those children who had probable malaria among those with fever onset in the 14 days prior to the study were identified retrospectively. Treatment coverage with AS+AQ was then estimated among these probable malaria cases.
  
  
  RESULTS
  Out of 195 children with fever on the day of the study, 92 were confirmed as true malaria cases and 103 tested negative. The combination of 'loss of appetite', 'sweating', 'shivering' and 'intermittent fever' yielded the highest possible positive predictive value, and was chosen as the case definition of malaria. Out of 526 children who had had fever 14 days prior to the survey, 165 (31.4%) were defined as probable malaria cases using this definition. Among them, 20 (14.1%) had been treated with AS+AQ, 10 with quinine (5%), 68 (41%) received non-malaria treatments, and 67 got traditional treatment or nothing (39.9%). Most people sought treatment from public health centres (23/99) followed by private clinics (15/99, 14.1%). The median price paid for AS+AQ was 0.5 US$.
  
  
  CONCLUSIONS
  AS+AQ was the most common treatment for patients with probable malaria at public health centres, but coverage was low due to low health centre utilisation and apparently inappropriate prescribing. In addition, AS+AQ was given to patients at a price ten times higher than the subsidized price. The availability and proper use of ACTs should be monitored and maximized after their introduction in order to have a significant impact on the burden of malaria.
authors.affiliation: Epicentre, Paris, France. sibylle.gerstl@epicentre.msf.org
authors.forename: Sibylle
authors.initials: S
authors.lastname: Gerstl
authors.forename: Sandra
authors.initials: S
authors.lastname: Cohuet
authors.forename: Kodjo
authors.initials: K
authors.lastname: Edoh
authors.forename: Christopher
authors.initials: C
authors.lastname: Brasher
authors.forename: Alexandre
authors.initials: A
authors.lastname: Lesage
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Guthmann
authors.forename: Francesco
authors.initials: F
authors.lastname: Checchi
mesh_terms: D000655:Amodiaquine / Q000627:therapeutic use*; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins / Q000627:therapeutic use*; D000077332:Artesunate; D002063:Burundi / Q000453:epidemiology; D002675:Child, Preschool; D003153:Community Health Services / Q000191:economics / Q000379:methods; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination; D005334:Fever / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008288:Malaria / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D012717:Sesquiterpenes / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D000655:Amodiaquine; D000077332:Artesunate