[Antibody to IL-1 or IL-15].
There have recently been fewer publications written in Japanese describing inflammatory cytokines in rheumatoid arthritis (RA) other than tumor necrosis factor and interleukin (IL) -6. Interleukins such as IL-1 and IL-15 are thought to play an important role, at least in part, in pathogenesis of RA. In this review, the two interleukins above were mentioned from mainly RA point of view, respectively. Monoclonal antibody to each cytokine might be brought to the clinic in the future.
Akama
Hideto
H
Medical Director, Inflammation, Bone, Metabolism, R & D Japan, Amgen K.K.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology* / Q000502:physiology; D019409:Interleukin-15 / Q000276:immunology* / Q000502:physiology; D017472:Receptors, Interleukin-1 / Q000502:physiology
D000911:Antibodies, Monoclonal; D007375:Interleukin-1; D019409:Interleukin-15; D017472:Receptors, Interleukin-1