title: A new dihydroagarofuranoid sesquiterpene from Microtropis fokienensis with antituberculosis activity.
abstract: A new dihydroagarofuran-based sesquiterpene, 8-acetoxymutangin (1), was isolated from the stems of Microtropis fokienensis, together with eight known compounds, including mutangin (2). Their structures were determined through in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 1 exhibited potent in vitro antituberculosis activity, with an MIC value of 10.0 microg/ml against Mycobacterium tuberculosis 90-221387, which is considerably better than that of mutangin (2). The activity of 1 lies in the same range as that of the clinic drug ethambutol (MIC 6.25 microg/ml), despite completely different chemical structures, which indicates different modes of action.
authors.affiliation: Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Chou
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Po-Chuen
authors.initials: PC
authors.lastname: Shieh
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000995:Antitubercular Agents / Q000302:isolation & purification* / Q000494:pharmacology; D029753:Celastraceae; D008826:Microbial Sensitivity Tests / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D010936:Plant Extracts; D012717:Sesquiterpenes; C079978:dihydroagarofuran