Dietary patterns, Mediterranean diet, and endometrial cancer risk.
This study examines the association between dietary patterns and endometrial cancer risk. A case-control study of endometrial cancer was conducted from 1996 to 1999 in the San Francisco Bay Area in white, African-American, and Latina women age 35-79. Dietary patterns were defined using a principal components analysis; scoring dietary intake based on correspondence to a Mediterranean-style diet; and by jointly categorizing intake of fruits/vegetables and dietary fat. Four dietary patterns were identified and labeled "plant-based," "western," "ethnic," and "phytoestrogen-rich." None of these dietary patterns nor adherence to a Mediterranean diet (to the extent consumed by this population) was associated with endometrial cancer risk. However, among non-users of supplements, greater consumption of the "western" dietary pattern was associated with a 60% increase in risk (95% CI: 0.95-2.7 per unit change; P-interaction = 0.10). A diet characterized by high fat consumption increased risk, regardless of fruit and vegetable consumption (OR = 1.4, 95% CI: 0.97-2.1 for high fat, low fruit/vegetable intake and OR = 1.4, 95% CI: 0.95-2.1 for high fat, high fruit/vegetable intake compared to low fat, high fruit/vegetable intake). Thus, while like others we found that dietary fat increases endometrial cancer risk, the evaluation of dietary patterns did not provide any additional information regarding risk.
Dalvi
Tapashi B
TB
Northern California Cancer Center, 2201 Walnut Avenue, Fremont, CA 94538, USA.
Canchola
Alison J
AJ
Horn-Ross
Pamela L
PL
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016001:Confidence Intervals; D004032:Diet; D038441:Diet, Mediterranean; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects; D004043:Dietary Fiber / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D016889:Endometrial Neoplasms / Q000208:ethnology / Q000209:etiology* / Q000517:prevention & control; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D005638:Fruit; D006801:Humans; D007407:Interviews as Topic; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D048789:Phytoestrogens; D028321:Plant Preparations; D010945:Plants, Edible; D017698:Postmenopause; D017697:Premenopause; D025341:Principal Component Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014675:Vegetables
D004041:Dietary Fats; D004043:Dietary Fiber; D004044:Dietary Proteins; D048789:Phytoestrogens; D028321:Plant Preparations