[Detection rates of various serotypes of human papilloma virus in atypical glandular hyperplasia and adenocarcinoma of the endometrium and their immunomorphological features in virus-positive cases].
Various virus serotypes were found in 35.3% of cases and their detection rate frequency reducing with age. They were detectable in 35.3 -52.9% of cases of atypical glandular hyperplasia, highly and moderately differentiated adenocarcinoma of the endometrium and only in 17.6% of cases of poorly differentiated adenocarcinomas. Serotypes 58 and 51 were nearly twice more frequently, but serotypes 18 and 52 were not observed. Immunomorphologically virus-positive observations were characterized by pronounced infiltration with T-helper and T-suppressor/killer cells. The endometrium and tumors showed an increased significant proliferative activity (Ki-67 expression) and reduced expression of receptors to progesterone and, to a lesser degree, to estrogen in 47-83% of virus-positive cases. Expression of growth factors did not greatly differ.
Levakov
S A
SA
Zaĭrat'iants
O V
OV
Sidorova
I S
IS
Opalenov
K V
KV
Ali
A G
AG
D000230:Adenocarcinoma / Q000453:epidemiology / Q000276:immunology / Q000473:pathology / Q000821:virology; D000328:Adult; D000368:Aged; D004714:Endometrial Hyperplasia / Q000453:epidemiology / Q000276:immunology / Q000473:pathology / Q000821:virology; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000276:immunology / Q000473:pathology / Q000821:virology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000276:immunology; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000276:immunology / Q000473:pathology / Q000821:virology; D016133:Polymerase Chain Reaction; D012698:Serologic Tests; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D019394:Ki-67 Antigen