Adenovirus-associated hemorrhagic cystitis in a pediatric renal transplant recipient.
Adenovirus infection has been associated with the development of hemorrhagic cystitis in bone marrow transplant recipients. However, limited information exists regarding adenovirus-associated hemorrhagic cystitis in solid organ transplantation, especially in renal transplant recipients. In most cases, the disease is self-limited. However, some patients may have a protracted course. Although no particular antiviral agent has been identified as the gold standard of therapy, cidofovir has been found to be effective in a number of bone marrow transplant recipients. In this study, we report a five-yr-old boy who presented with adenovirus-associated hemorrhagic cystitis 68 days after renal transplant and was successfully treated with reduction of immunosuppression and an intermediate dose of intravenous cidofovir.
Keswani
Mahima
M
Department of Pediatrics, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA.
Moudgil
Asha
A
D000256:Adenoviridae / Q000235:genetics / Q000302:isolation & purification; D000257:Adenoviridae Infections / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D000998:Antiviral Agents / Q000627:therapeutic use; D002675:Child, Preschool; D000077404:Cidofovir; D003556:Cystitis / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D005500:Follow-Up Studies; D006417:Hematuria / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D063065:Organophosphonates / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D011183:Postoperative Complications
D000998:Antiviral Agents; D004279:DNA, Viral; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir