title: Poor late prognosis of bleeding peptic ulcer.
abstract: OBJECTIVE
  Long-term course of peptic ulcer bleeding is unclear. Because of a more aged and more diseased ulcer population, the long-term prognosis may be expected as poor.
  
  
  METHODS
  In a prospective study, all patients with peptic ulcer bleeding treated at the Department of Surgery of the Heinrich-Heine-University in Düsseldorf were included between 1986 and 1995. Follow-up covered hospital mortality, 1-month mortality, 1-year mortality, and 5-years mortality. Significant prognostic parameters for death were investigated in univariate and multivariate analysis.
  
  
  RESULTS
  One hundred and seventy-one out of 192 patients with peptic ulcer bleeding could be followed up. One-month mortality was similar to hospital mortality with 12.3%, 1-year mortality was 28.7%, and the 5-years mortality was 46.8%! In univariate analysis, statistically significant prognostic factors for death were ages beyond 70 years, concomitant diseases, risk-related drugs, postinterventional complications, and recurrent bleeding. In multivariate analysis, age, postinterventional complications, and type of admission were statistically significant parameters for death.
  
  
  CONCLUSIONS
  Long-term prognosis of peptic ulcer bleeding is poor! The majority of deaths after hospital stay is probably not because of ulcer bleeding, but because of more aged patients with severe concomitant diseases.
authors.affiliation: Department of General and Trauma Surgery, Malteser Hospital St. Hildegardis, Cologne, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Imhof
authors.forename: S
authors.initials: S
authors.lastname: Epstein
authors.forename: C
authors.initials: C
authors.lastname: Ohmann
authors.forename: H-D
authors.initials: HD
authors.lastname: Röher
mesh_terms: D000367:Age Factors; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000925:Anticoagulants / Q000009:adverse effects; D002423:Cause of Death; D003348:Cortisone / Q000009:adverse effects; D018572:Disease-Free Survival; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006305:Health Status Indicators; D006489:Hemostatic Techniques; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D013276:Stomach Ulcer / Q000139:chemically induced / Q000401:mortality / Q000601:surgery*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D003348:Cortisone