title: Polybrominated diphenyl ethers and persistent organochlorines in Japanese human adipose tissues.
abstract: The present study determined concentrations of polybrominated diphenyl ethers (PBDEs) and persistent organochlorines (OCs) in Japanese human adipose tissues collected during 2003-2004. Concentrations of PBDEs in adipose tissues were 1-2 orders of magnitude lower than those of OCs. However, observed PBDE congener levels in this study were relatively higher than those in Japanese human adipose tissues collected during 2000 reported previously, while OC levels were comparable to those in specimens collected during 1999 reported by our group. In addition, no age-dependent accumulation of PBDEs was observed, while OC levels except chlordane compounds increased with age. These results indicate recent human exposure to PBDEs in Japan. Among PBDE congeners accumulated in Japanese adipose tissues, BDE-153 was dominant, but this trend was different from those in human milk (BDE-47) and blood (BDE-209) reported previously in Japan, implying the congener-specific kinetics in human bodies. The significant positive correlations between PBDEs and OCs were observed in Japanese adipose tissues, indicating the similar exposure route of these contaminants for Japanese citizens, probably via fish intake.
authors.affiliation: Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kunisue
authors.forename: Nozomi
authors.initials: N
authors.lastname: Takayanagi
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Isobe
authors.forename: Shin
authors.initials: S
authors.lastname: Takahashi
authors.forename: Masato
authors.initials: M
authors.lastname: Nose
authors.forename: Taketo
authors.initials: T
authors.lastname: Yamada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Komori
authors.forename: Norimasa
authors.initials: N
authors.lastname: Arita
authors.forename: Norifumi
authors.initials: N
authors.lastname: Ueda
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Tanabe
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000378:metabolism*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000378:metabolism*; D007564:Japan; D008297:Male; D008875:Middle Aged; D010647:Phenyl Ethers / Q000378:metabolism*; D011075:Polybrominated Biphenyls / Q000378:metabolism*
chemical_list: D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls