title: [Multiple abscesses in immunocompetent patients caused by Panton-Valentine leukocidin positive Staphylococcus aureus].
abstract: We report cases of immunocompetent patients showing multiple abscesses by a Panton-Valentine leukocidin (PVL) positive Staphylococcus aureus. PVL is considered to be an important virulence factor. The most common manifestations by this pathogen are recurrent or multiple abscesses of the skin. Seldom necrotizing pneumonia with high mortality occurs. Even methicillin-resistant PVL positive isolates have been identified in Germany. Only appropriate infection control measures in combination with antimicrobial therapy resulted in successful eradication of this pathogen. Dermatologists should be informed about this specific type of infection and about the appropriate infection control measures.
authors.affiliation: Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover. Vonberg.Ralf@MH-Hannover.de
authors.forename: R-P
authors.initials: RP
authors.lastname: Vonberg
authors.forename: L
authors.initials: L
authors.lastname: Sedlacek
authors.forename: I F
authors.initials: IF
authors.lastname: Chaberny
authors.forename: S
authors.initials: S
authors.lastname: Suerbaum
authors.forename: P
authors.initials: P
authors.lastname: Gastmeier
authors.forename: H-J
authors.initials: HJ
authors.lastname: Linde
mesh_terms: D000038:Abscess / Q000188:drug therapy / Q000382:microbiology* / Q000517:prevention & control; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001427:Bacterial Toxins; D002648:Child; D024881:Drug Resistance, Bacterial; D005098:Exotoxins; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017053:Infection Control; D007956:Leukocidins; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D011023:Pneumonia, Staphylococcal / Q000209:etiology; D012008:Recurrence; D012189:Retrospective Studies; D013207:Staphylococcal Skin Infections / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D013997:Time Factors; D016896:Treatment Outcome; D014774:Virulence
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D008712:Methicillin