Myocardial texture in hypertrophic cardiomyopathy.
BACKGROUND
This study was conceived to assess associations between integrated backscatter signal at end diastole (IBS) and diastolic properties in patients with hypertrophic cardiomyopathy.


METHODS
In 46 patients with hypertrophic cardiomyopathy, septal IBS was calculated by both applying an appropriate regression correction (IBSc) and by relating it to pericardial reflectivity (IBSp). Difference in duration between transmitral forward and pulmonary venous backward velocities (A-Ar) was measured as an estimate of passive diastolic filling. In all, 38 patients underwent ambulatory electrocardiogram monitoring for 48 hours.


RESULTS
IBS inversely correlated to both A-Ar (IBSc, r = -.522, P < .001; IBSp, r = -.302, P = .041) and mitral peak velocity at atrial contraction (IBSc, r = -.464, P = .002; IBSp, r = -.413, P = .004). Moreover, IBS was greater in patients with sustained or nonsustained ventricular tachycardia (IBSc, 28.5 +/- 3.8 vs 25.4 +/- 3.8 dB, P = .034).


CONCLUSIONS
Septal IBS correlates with Doppler parameters of left ventricular chamber stiffness in patients with hypertrophic cardiomyopathy. Increased IBS is associated with presence of ventricular arrhythmias.
Losi
Maria-Angela
MA
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University School of Medicine, Naples, Italy.
Betocchi
Sandro
S
Chinali
Marcello
M
Barbati
Giovanni
G
D'Alessandro
Gianluigi
G
Cacace
Alessandra
A
Lombardi
Raffaella
R
Contaldi
Carla
C
de Simone
Giovanni
G
Chiariello
Massimo
M
D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000000981:diagnostic imaging*; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000000981:diagnostic imaging*