title: [Pathophysiological mechanisms of lower limb chronic venous insufficiency and possibility of its correction with Antistax].
abstract: Symptoms of lower limb chronic venous insufficiency (CVI) are related to hypertension in vena cava inferior system. All changes that take place in macrocirculatory segment of hemodynamics are reflected at microcirculatory level, including metabolic and trophic processes -- the most important function of microcirculation, which is named "transcapillary exchange". Endothelial dysfunction and blood-venous wall interface changes play a crucial role in the development of pathology. Drug therapy remains the main and integral part of CVI treatment. One of its aims is to protect venous wall, normalize permeability and alleviate CVI symptoms at microcirculatory level. Antistax efficiency in patients with CVI was demonstrated in several trials and warranted the inclusion of this drug into complex treatment of lower limb CVI.
authors.affiliation: N I Pirogov National MedicoSurgical Center, Moscow, Russia.
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Stoĭko
authors.forename: V G
authors.initials: VG
authors.lastname: Gudymovich
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D002908:Chronic Disease; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply* / Q000503:physiopathology*; D011794:Quercetin / Q000031:analogs & derivatives / Q000627:therapeutic use; D012431:Rutin / Q000627:therapeutic use; D014689:Venous Insufficiency / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D000975:Antioxidants; C522873:Antistax; D012431:Rutin; D011794:Quercetin