[Thioctic acid action on glutathione-dependent antioxidant system functioning at toxic hepatitis of rats].
The effect of thioctic acid on the glutathione dependent antioxidant system and activities of enzymes, generating NADPH of rats has been investigated in rats under conditions of toxic hepatitis. Injections of thioctic acid to animals with toxic hepatitis caused the decrease of glutathione reductase and peroxidase activities to the normal level. Reduced glutathione content also tended to the control level. Administration of thioctic acid to rats with toxic hepatitis also caused the decrease of NADP-dependent isocitrate dehydrogenase and glucose-6-phosphate dehydrogenase which might be associated with decreasing need of NADPH supply for glutathione dependent antioxidant system. Thus, obtained results have shown that thioctic acid may regulate manifestations of oxidative stress and the state of the glutathione antioxidant system.
Makeeva
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Popova
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Matasova
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D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002251:Carbon Tetrachloride / Q000633:toxicity; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology*; D005978:Glutathione / Q000378:metabolism*; D008297:Male; D009249:NADP / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D008063:Thioctic Acid / Q000494:pharmacology*; D014803:Vitamin B Complex / Q000494:pharmacology*
D000975:Antioxidants; D014803:Vitamin B Complex; D009249:NADP; D008063:Thioctic Acid; D002251:Carbon Tetrachloride; D010088:Oxidoreductases; D005978:Glutathione