title: Specific recognition of loop DNA by dicationic porphyrins.
abstract: A series of dicationic porphyrins were found to specifically recognize loop structures of oligodeoxynucleotides, and to selectively oxidize guanine residues upon photo-irradiation at micromolar concentrations. These compounds could, thus, be employed as promising structural probes for specific secondary DNA structures. The production of singlet oxygen ((1)O2) is responsible for the DNA-modification profiles. Both UV-titration and thermal-melting experiments indicate that the strong affinity of the charged porphyrins towards DNA loops is responsible for these molecular-recognition phenomena.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China.
authors.forename: Xiao-Cheng
authors.initials: XC
authors.lastname: Weng
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.forename: Song
authors.initials: S
authors.lastname: Wu
authors.forename: Li-Ge
authors.initials: LG
authors.lastname: Ren
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Weng
authors.forename: Shu-Gao
authors.initials: SG
authors.lastname: Zhu
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D001665:Binding Sites / Q000502:physiology; D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D011166:Porphyrins / Q000235:genetics* / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
chemical_list: D011166:Porphyrins; D004247:DNA