title: Cu-catalyzed tandem C-N bond formation for the synthesis of pyrroles and heteroarylpyrroles.
abstract: A highly efficient Cu-catalyzed tandem C-N bond-forming reaction of 1,4-dihalo-1,3-dienes has been developed. The transformation allows the synthesis of pyrroles and heteroarylpyrroles with a wide variety of functional groups and substitution patterns from readily available precursors.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Rubén
authors.initials: R
authors.lastname: Martín
authors.forename: Catharine H
authors.initials: CH
authors.lastname: Larsen
authors.forename: Ana
authors.initials: A
authors.lastname: Cuenca
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis; D011758:Pyrroles / Q000138:chemical synthesis*
chemical_list: D000475:Alkenes; D006571:Heterocyclic Compounds; D006846:Hydrocarbons, Halogenated; D011758:Pyrroles; D003300:Copper