title: Lipid-lowering effect of hot water-soluble extracts of Saururus chinensis Bail on rats fed high fat diets.
abstract: We evaluated the inhibition of low-density lipoprotein (LDL) oxidation inhibition by a hot water-soluble extract of Saururus chinensis Bail (HWSCB) in vitro and the lipid-lowering effects of HWSCB in rats fed high fat diet (HFD). HFDs were supplemented with 5% HWSCB (HFSCB5 group), 10% HWSCB (HFSCB10 group), or 1% tannic acid (Tannin group). The Tannin group served as a positive control for the study, based on tannic acid's known lipid-lowering effect and water-soluble characteristics. LDL oxidation was dose-dependently inhibited in the presence of HWSCB, and the effect of HWSCB was comparable to that of vitamin C. Significant reductions in triglyceride (P < .05) and cholesterol (P < .05) levels in the plasma and liver of the HFSCB5, HFSCB10, and Tannin groups were observed. High-density lipoprotein cholesterol was elevated (P < .05), but LDL was decreased in a dose-dependent manner for the HFSCB samples. These results were associated with a significant decrease in the atherogenic index for the HFSCB samples, especially for HFSCB10. In addition, fecal excretion of triglyceride with HWSCB supplementation was greater than with tannic acid supplementation. The findings of this study suggest that HWSCB may reduce plasma and hepatic lipids, especially triglyceride, in rats fed high fat diet.
authors.affiliation: Department of Food Science and Nutrition, Pusan National University, Busan, Republic of Korea.
authors.forename: Ye Rang
authors.initials: YR
authors.lastname: Yun
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Myung Ja
authors.initials: MJ
authors.lastname: Kwon
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Kim
authors.forename: Yeong Bok
authors.initials: YB
authors.lastname: Song
authors.forename: Kyung Bin
authors.initials: KB
authors.lastname: Song
authors.forename: Yeong Ok
authors.initials: YO
authors.lastname: Song
mesh_terms: D000818:Animals; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage*; D004435:Eating; D005243:Feces / Q000737:chemistry; D006358:Hot Temperature; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000032:analysis / Q000097:blood; D008077:Lipoproteins, LDL / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D032134:Saururaceae / Q000737:chemistry*; D012995:Solubility; D014280:Triglycerides / Q000032:analysis / Q000097:blood; D014867:Water
chemical_list: D004041:Dietary Fats; D000960:Hypolipidemic Agents; D008055:Lipids; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D014280:Triglycerides; D014867:Water