Methods of evaluating the effect of pharmacological drugs on aging and life span in mice.
The methodology of testing anti-aging drugs in laboratory mice is presented. It includes the selection of mouse strain, sex, age at start of treatment, housing conditions, design of the long-term study, some noninvasive methods of assessment, pathology examination, and statistical treatment of the results.
Anisimov
Vladimir N
VN
Department of Carcinogenis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.
Popovich
Irina G
IG
Zabezhinski
Mark A
MA
D000375:Aging / Q000187:drug effects; D000818:Animals; D004353:Drug Evaluation, Preclinical; D006801:Humans; D051379:Mice; D008954:Models, Biological