title: Aseptic meningitis associated with cephalosporins in an infant with trisomy 21.
abstract: The authors report a case of aseptic meningitis associated with cephalosporins in an infant. A 1-year-old boy with trisomy 21 received several antimicrobials including cefotaxime and ceftriaxone for bacterial meningitis caused by Haemophilus influenzae b. High fever continued for more than a month, and discontinuation of cefotaxime broke the fever and improved the findings of cerebrospinal fluid. Because third-generation cephalosporins are the first choice against bacterial meningitis for infants, recognition and diagnosis of this rare occurrence of drug-induced aseptic meningitis is important. It is treatable by withdrawal of the drug, and recurrence can be prevented.
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Akita, Japan. wakonakajima@hotmail.com
authors.forename: Wako
authors.initials: W
authors.lastname: Nakajima
authors.forename: Akira
authors.initials: A
authors.lastname: Ishida
authors.forename: Maya
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Sato
authors.forename: Tomoo
authors.initials: T
authors.lastname: Ito
authors.forename: Goro
authors.initials: G
authors.lastname: Takada
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001831:Body Temperature / Q000187:drug effects; D002097:C-Reactive Protein / Q000378:metabolism; D002511:Cephalosporins / Q000009:adverse effects*; D004314:Down Syndrome / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D006193:Haemophilus influenzae / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D008297:Male; D008582:Meningitis, Aseptic / Q000209:etiology*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002097:C-Reactive Protein