title: Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity.
abstract: Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines represent a novel class of compounds with activity against pestiviruses and the hepatitis C virus (HCV). Several series of analogues with modifications of the substituents in positions 2 and 5 were prepared. These efforts resulted in the discovery of several compounds with potent antiviral activity of which 2-(2,3-difluorophenyl)-5-[4-(trifluoromethyl)benzyl]-5H-imidazo[4,5-c]pyridine (46) was most potent against HCV (EC(50) of 0.10 microM and a selectivity index of 1080).
authors.affiliation: Institut für Pharmazie, Abteilung Pharmazeutische Chemie, Universität Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria. Gerhard.Puerstinger@uibk.ac.at
authors.forename: Gerhard
authors.initials: G
authors.lastname: Puerstinger
authors.forename: Jan
authors.initials: J
authors.lastname: Paeshuyse
authors.forename: Susanne
authors.initials: S
authors.lastname: Heinrich
authors.forename: Joachim
authors.initials: J
authors.lastname: Mohr
authors.forename: Nicole
authors.initials: N
authors.lastname: Schraffl
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Johan
authors.initials: J
authors.lastname: Neyts
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011725:Pyridines