Suppressive effects of bisphenol A on the proliferation of neural progenitor cells.
Endocrine disruptors (EDs) exert adverse effects on reproductive and immune function or neurological behavior. Bisphenol A (BPA), one of the environmental EDs, is widely used in the manufacture of plastics and epoxy resins. Studies reported that BPA affects reproductive organ growth and development. However, the potential adverse effects of BPA on neuronal development have not been fully explored. In this study, the potent harmful effects of BPA were investigated on the murine-derived multipotent neural progenitor cells (NPCs). Pretreatment of BPA significantly decreased proliferation of NPCs in a concentration-dependent manner. Moreover, at a high concentration (> 400 microM), BPA was cytotoxic to NPCs. However, the low concentrations of BPA, previously shown to exert estrogenic actions, did not affect the proliferation of NPCs. BPA altered the activation of extracellular signal-regulated kinases and c-Jun-N-Kinases in a different manner without affecting activities of p38 kinases. It was also found that reactive oxygen species (ROS) were elevated in NPCs exposed to high concentrations of BPA, indicating oxidative stress-related cytotoxicity. These data show adverse effects of BPA on the nervous system and potentially on neonatal brain development.
Kim
Keunho
K
Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong-gu, Busan, Republic of Korea.
Son
Tae Gen
TG
Kim
So Jung
SJ
Kim
Hyung Sik
HS
Kim
Tae Sung
TS
Han
Soon Young
SY
Lee
Jaewon
J
D000818:Animals; D001559:Benzhydryl Compounds; D001921:Brain / Q000187:drug effects / Q000254:growth & development; D016923:Cell Death / Q000187:drug effects*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D052244:Endocrine Disruptors / Q000633:toxicity*; D051379:Mice; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology; D018384:Oxidative Stress; D010636:Phenols / Q000633:toxicity*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013234:Stem Cells / Q000187:drug effects* / Q000201:enzymology; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; D017382:Reactive Oxygen Species; C006780:bisphenol A; D000098826:Bisphenol A Compounds