[Effect of Xinmaitong capsule on serum matrix metalloproteinases-9, high sensitive C-reactive protein levels in patients with acute coronary syndrome].
OBJECTIVE
To observe the influence of Xinmaitong capsule (XMT) on serum matrix metalloproteinases-9, high sensitive C-reactive protein levels in patients with acute coronary syndrome.


METHODS
63 cases were divided by randomized, contrastive assigned to XMT group (n = 31) and control group (n = 32). The serum levels of MMP-9 and hs-CRP before and after treatment in 12 weeks were detected.


RESULTS
After treatment, the serum levels of MMP-9 in control group had no changed and the levels of hs-CRP reduced. The serum levels of MMP-9 and hs-CRP in XMT group had significantly decreased. The serum levels of MMP-9 and hs-CRP had positive correlation, but had no correlation to levels of serum lipids.


CONCLUSIONS
XMT decreased breakdown of matrix collagen, and inflammatory reaction in the patients of ACS, which may have effect on plaque stabilization.
Meng
Jun
J
The First Affiliated Hospital, Sun Yat-sen UniverSity, Guangzhou 510058, China. jder@sohu.com
Qin
Jian
J
Ma
Yun
Y
Sun
Hui-Ma
HM
Luo
Chu-Fan
CF
Qiu
Rui-Xiang
RX
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000188:drug therapy*; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D002214:Capsules; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
D002214:Capsules; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D014280:Triglycerides; C530084:xinmaitong; D002097:C-Reactive Protein; D002784:Cholesterol; D020780:Matrix Metalloproteinase 9