Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma.
Carcinomas are characterized by invasion of malignant cells into the underlying connective tissue and migration of malignant cells to form metastases at distant sites. These processes require alterations in cell-cell and cell-extracellular matrix interactions. As cell adhesion molecules play a role in cell-cell and cell-extracellular matrix adhesion and interactions they are involved in the process of tumour invasion and metastases. In epithelial tissues, receptors of the integrin family mediate adhesion to the adjacent matrix whereas cadherins largely mediate intercellular adhesion. These and other cell adhesion molecules such as intercellular adhesion molecule-1, CD44, dystroglycans and selectins, are involved and undergo changes in carcinomas, which provide possible targets for anti-cancer drug treatments. In the extracellular matrix that is associated with tumours, laminin 5, oncofetal fibronectin and tenascin C appear. The degree of expression of some of these moieties indicates prognosis in oral cancer and offer targets for antibody-directed radiotherapy. Metalloproteases which degrade the extracellular matrix are increased in carcinomas, and their activity is necessary for tumour angiogenesis and consequent invasion and metastases. Metalloprotease inhibitors have begun to produce decreases in mortality in clinical trials. This report provides a brief overview of our current understanding of cell adhesion molecules, the extracellular matrix, tumour invasion and metastasis.
Lyons
A J
AJ
Department of Oral & Maxillofacial Surgery, Guy's Hospital, London SE1 9RT, UK.
Jones
J
J
D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000556:secondary*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D049030:Dystroglycans / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology*; D018960:Hyaluronan Receptors / Q000502:physiology; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000502:physiology*
C497483:CD44 protein, human; D015815:Cell Adhesion Molecules; D018960:Hyaluronan Receptors; D009363:Neoplasm Proteins; D049030:Dystroglycans