Aplasics born without hands mirror the goal of hand actions with their feet.
The premotor and parietal mirror neuron system (MNS) is thought to contribute to the understanding of observed actions by mapping them onto "corresponding" motor programs of the observer [1-24], but how would the MNS respond to the observation of hand actions if the observer never had hands? Would it not show changes of blood-oxygen-level dependent (BOLD) signal, because the observer lacks motor programs that can resonate [12, 25, 26], or would it show significant changes because the observer has motor programs for the foot or mouth with corresponding goals [15, 17, 19, 27, 28]? We scanned two aplasic subjects, born without arms or hands, while they watched hand actions and compared their brain activity with that of 16 control subjects. All subjects additionally executed actions with different effectors (feet, mouth, and, for controls, hands). The BOLD signal of aplasic individuals within the putative MNS was augmented when they watched hand actions, demonstrating the brain's capacity to mirror actions that deviate from the embodiment of the observer by recruiting voxels involved in the execution of actions that achieve corresponding goals by different effectors. This sheds light on the functional organization of the MNS and predominance of goals in imitation.
Gazzola
Valeria
V
BCN Neuroimaging Center, University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713 AW Groningen, The Netherlands.
van der Worp
Henk
H
Mulder
Theo
T
Wicker
Bruno
B
Rizzolatti
Giacomo
G
Keysers
Christian
C
D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000502:physiology*; D005528:Foot / Q000502:physiology*; D006040:Goals; D006225:Hand / Q000502:physiology*; D006228:Hand Deformities, Congenital / Q000503:physiopathology*; D006801:Humans; D007100:Imitative Behavior / Q000502:physiology*; D010100:Oxygen / Q000097:blood
D010100:Oxygen