title: A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.
abstract: Psalmotoxin 1, a peptide extracted from the South American tarantula Psalmopoeus cambridgei, has very potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents. It exerts its action by blocking acid-sensing ion channel 1a, and this blockade results in an activation of the endogenous enkephalin pathway. The analgesic properties of the peptide are suppressed by antagonists of the mu and delta-opioid receptors and are lost in Penk1-/- mice.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique (CNRS), Institut Paul Hamel, Université de Nice-Sophia-Antipolis, 660 Route des Lucioles 06560 Valbonne, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Mazzuca
authors.forename: Catherine
authors.initials: C
authors.lastname: Heurteaux
authors.forename: Abdelkrim
authors.initials: A
authors.lastname: Alloui
authors.forename: Sylvie
authors.initials: S
authors.lastname: Diochot
authors.forename: Anne
authors.initials: A
authors.lastname: Baron
authors.forename: Nicolas
authors.initials: N
authors.lastname: Voilley
authors.forename: Nicolas
authors.initials: N
authors.lastname: Blondeau
authors.forename: Pierre
authors.initials: P
authors.lastname: Escoubas
authors.forename: Agnès
authors.initials: A
authors.lastname: Gélot
authors.forename: Anny
authors.initials: A
authors.lastname: Cupo
authors.forename: Andreas
authors.initials: A
authors.lastname: Zimmer
authors.forename: Anne M
authors.initials: AM
authors.lastname: Zimmer
authors.forename: Alain
authors.initials: A
authors.lastname: Eschalier
authors.forename: Michel
authors.initials: M
authors.lastname: Lazdunski
mesh_terms: D062565:Acid Sensing Ion Channels; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D019540:Area Under Curve; D001522:Behavior, Animal; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004745:Enkephalins / Q000172:deficiency / Q000502:physiology*; D008565:Membrane Proteins / Q000172:deficiency / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009020:Morphine / Q000008:administration & dosage; D009270:Naloxone / Q000008:administration & dosage; D009271:Naltrexone / Q000008:administration & dosage; D009292:Narcotic Antagonists / Q000008:administration & dosage; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement / Q000379:methods; D010455:Peptides; D011498:Protein Precursors / Q000172:deficiency; D011930:Reaction Time / Q000187:drug effects; D015222:Sodium Channels / Q000172:deficiency / Q000502:physiology*; D013111:Spider Venoms / Q000627:therapeutic use*; D013116:Spinal Cord / Q000473:pathology; D013997:Time Factors
chemical_list: C568267:ASIC1 protein, mouse; D062565:Acid Sensing Ion Channels; D000700:Analgesics; D004745:Enkephalins; D008565:Membrane Proteins; D009292:Narcotic Antagonists; D009419:Nerve Tissue Proteins; C413209:PcTX1 protein, Psalmopoeus cambridgei; D010455:Peptides; D011498:Protein Precursors; D015222:Sodium Channels; D013111:Spider Venoms; D009270:Naloxone; D009271:Naltrexone; D009020:Morphine; C033660:preproenkephalin