title: [Efficacy of total removal or subtotal removal combined gamma knife radiation on giant pituitary adenoma: a report of 160 cases].
abstract: OBJECTIVE
  Pituitary adenoma, a kind of familiar benign intracranial tumor, is mainly treated with surgical operation, medication, and radiation. However, the outcome, especially for giant pituitary adenoma, is not very satisfactory. This study was to explore the efficacy of total tumor removal or subtotal tumor removal combined gamma knife radiation on giant pituitary adenoma.
  
  
  METHODS
  Clinical data of 160 giant pituitary adenoma patients were analyzed. Of the 160 patients, 90 received total tumor removal, 70 received subtotal tumor removal combined gamma knife radiation. The symptom improvement, tumor size change, serum hormone concentration, complications after treatment, and so on, of the 2 groups were compared.
  
  
  RESULTS
  At 12 months after treatment, the efficiency rate, recurrence rate, and mortality were 74.4%, 31.1%, and 3.3%, respectively, in total tumor removal group; however, the efficiency rate reached 91.4%, the recurrence rate decreased to 11.4%, and no patients died in combined therapy group. The follow-up results at 24 months after treatment and at present (over 5 years) showed that though the efficiency rate had descended and recurrence rate or mortality had ascended in both groups, the efficacy of combined therapy was obviously better than that of total tumor removal. The decrease of serum hormone concentration was more obvious in combined therapy group than in total tumor removal group at 12 months after treatment. Moreover, total tumor removal group had more serious complications than combined therapy group after treatment.
  
  
  CONCLUSIONS
  Subtotal tumor removal combined gamma knife radiation is better than total tumor removal for giant pituitary adenoma.
authors.affiliation: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
authors.forename: Qi-Hua
authors.initials: QH
authors.lastname: Xiao
authors.forename: Si-Qing
authors.initials: SQ
authors.lastname: Huang
authors.forename: Bo-Yong
authors.initials: BY
authors.lastname: Mao
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Ju
mesh_terms: D000236:Adenoma / Q000097:blood / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D003919:Diabetes Insipidus / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000097:blood; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000097:blood / Q000601:surgery; D006801:Humans; D006944:Hyperglycemic Hyperosmolar Nonketotic Coma / Q000209:etiology; D007016:Hypophysectomy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000097:blood / Q000601:surgery*; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000097:blood / Q000601:surgery; D016634:Radiosurgery / Q000009:adverse effects; D012189:Retrospective Studies
chemical_list: D011388:Prolactin; D013006:Growth Hormone