title: [Gastrointestinal gastric tumor (GIST) as a cause of massive hemorrhage from the upper digestive tract].
abstract: Gastrointestinal stromal tumors GIST are rare mesenchymal tumors of the gastrointestinal tract characterized by expression of a receptor that activates tyrosine kinase called C- kit. Since malignant GIST has an extremely poor prognosis even after surgical resection. The developement of a tyrosine kinase inhibitor, STI571/imatinib mesylate/Gleevec, Glivec which inhibits the BCR-ABL, PDGF-R alpha, and C-Kit receptors, has changed the management of unresectable malignant GIST and has improved the survival of patients with metastaic disease. We report a 32 year old male patient with subcardiale gastric GIST and massive gastrointestinale bleeding. The patient underwent total gastrectomy, D2 lymphadenestomy, distal pancreatectomy and splenectomy on 02.02. 2004. Histopathology examination of the primary tumor revealed a strong C-Kit expression and CD 34 +++, Ki67 20 and so called "Pure GIST" was approved Liver metastasis was detected on ultrasound and CT 12 months later and segmentectomy S7 was performed on 23.03.2005. Postoperative course was uneventfull. HP examination--malignant 35 x 30 mm sarcoma like tumor of mesenchymal origin. The patient received adjuvant imatinib-mesylate Gleevec Novartis Pharma Basel 400 mg a day. The initial complete response to treatment continued to 24 monts postoperatively Imatinib is a recent and very promising tretemenextirpation remains the only curative treatment of malignant GIST as evideneced by our patient.
authors.affiliation: Centar za hirurgiju, Urgentni Centar, KCS, Beograd.
authors.forename: V
authors.initials: V
authors.lastname: Djukić
authors.forename: A
authors.initials: A
authors.lastname: Karamarković
authors.forename: S
authors.initials: S
authors.lastname: Mijatović
authors.forename: M
authors.initials: M
authors.lastname: Micev
authors.forename: V
authors.initials: V
authors.lastname: Bumbasirević
authors.forename: M
authors.initials: M
authors.lastname: Djurović
authors.forename: D
authors.initials: D
authors.lastname: Stepić
authors.forename: V
authors.initials: V
authors.lastname: Jeremić
authors.forename: N
authors.initials: N
authors.lastname: Popović
authors.forename: A
authors.initials: A
authors.lastname: Sijacki
authors.forename: S
authors.initials: S
authors.lastname: Krsić
authors.forename: P
authors.initials: P
authors.lastname: Gregorić
mesh_terms: D000328:Adult; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D046152:Gastrointestinal Stromal Tumors / Q000150:complications* / Q000628:therapy; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000150:complications* / Q000628:therapy