title: Registration-derived estimates of local lung expansion as surrogates for regional ventilation.
abstract: The main function of the respiratory system is gas exchange. Since many disease or injury conditions can cause biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation. We describe a registration-based technique for estimating local lung expansion from multiple respiratory-gated CT images of the thorax. The degree of regional lung expansion is measured using the Jacobian of the registration displacement field. We compare lung expansion estimated across five pressure changes to a xenon CT based measure of specific ventilation, and have shown good agreement (linear regression, r2 = 0.89 during gas wash-in) in one animal.
authors.affiliation: Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA. joe-reinhardt@uiowa.edu
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Reinhardt
authors.forename: Gary E
authors.initials: GE
authors.lastname: Christensen
authors.forename: Eric A
authors.initials: EA
authors.lastname: Hoffman
authors.forename: Kai
authors.initials: K
authors.lastname: Ding
authors.forename: Kunlin
authors.initials: K
authors.lastname: Cao
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D016000:Cluster Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008168:Lung / Q000000981:diagnostic imaging* / Q000502:physiology*; D008176:Lung Volume Measurements / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods; D012123:Pulmonary Ventilation / Q000502:physiology*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D013902:Radiography, Thoracic / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods