title: The effect of ambulation on vaginal distribution of miconazole nitrate (1200 mg).
abstract: OBJECTIVE
  To evaluate the effect activity has on the vaginal distribution of a 1200 mg miconazole nitrate gelatin encapsulated insert, an antifungal agent commonly used to treat vaginal vulvocandidiasis.
  
  
  METHODS
  Nine subjects underwent two sessions of serial magnetic resonance imaging after insertion of the insert. One session required that the subjects ambulate between images; the other session required the subjects remain supine between images. Vaginal distribution of the insert was quantified by calculating surface contact and linear distance in every image. Comparison of spread was then done between images taken in active subjects and images taken in resting subjects. Time until capsule dissolution was also compared between the two groups.
  
  
  RESULTS
  No statistically significant difference was seen in spread of insert between the active and resting group. Activity also had no significant effect on capsule dissolution.
  
  
  CONCLUSIONS
  Activity does not appear to hinder the spread of the insert, suggesting that this medication can be used daytime or nighttime.
authors.affiliation: Reproductive Research Unit, Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Seema
authors.initials: S
authors.lastname: Menon
authors.forename: Adrianna
authors.initials: A
authors.lastname: Izquierdo
authors.forename: Mark
authors.initials: M
authors.lastname: Rosen
authors.forename: Amy
authors.initials: A
authors.lastname: Hummel
authors.forename: Kurt
authors.initials: K
authors.lastname: Barnhart
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008825:Miconazole / Q000008:administration & dosage*; D013535:Suspensions; D016896:Treatment Outcome; D014621:Vagina / Q000187:drug effects / Q000378:metabolism*; D014622:Vaginal Creams, Foams, and Jellies / Q000008:administration & dosage
chemical_list: D000935:Antifungal Agents; D013535:Suspensions; D014622:Vaginal Creams, Foams, and Jellies; D008825:Miconazole