No evidence for myocardial iron overload in multitransfused patients with myelodysplastic syndrome using cardiac magnetic resonance T2 technique.
The method of cardiovascular T2 magnetic resonance imaging (MRI) allows in vivo estimation of iron in the heart and liver and was used to measure the degree of iron overload in 10 transfused MDS patients (average 90 blood units) and in 3 patients with congenital hemolytic anemia. In all MDS patients iron overload was found in the liver but not in the heart. Patients with congenital anemias had iron in both organs despite iron chelation. It is possible that in MDS more time and more transfusions are required to induce iron accumulation in the myocardium. Therefore, cardiac MRI may serve as a diagnostic tool to assess if and when iron chelation is indicated.
Konen
Eli
E
Department of Diagnostic Imaging, Chaim Sheba Medical Center, Tel Hashomer, Israel. eli.konen@sheba.health.gov.il
Ghoti
Husam
H
Goitein
Orly
O
Winder
Asher
A
Kushnir
Tammi
T
Eshet
Yael
Y
Rachmilewitz
Eliezer
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis* / Q000378:metabolism; D019190:Iron Overload / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000628:therapy; D009206:Myocardium / Q000737:chemistry* / Q000378:metabolism; D065227:Transfusion Reaction
D007501:Iron