title: [Preparation and quality evaluation of quercetin self-emulsifyied drug delivery systems].
abstract: OBJECTIVE
  To prepare the quercetin self-emulsified formulation and evaluate its quality.
  
  
  METHODS
  The quercetin self-emulsified formulation was optimized based on the quercetin solubility in different oils, and the self-microemulsified efficiency of various combinations of emulsifier and co-emulsifier evaluated using the pseudo-ternary phase diagram. The microemulsion of morphology, size and zeta potential were examined. The quercetin of solubility in self-emulsified system was tested and the formulation stability was investigated by accelerated experiment.
  
  
  RESULTS
  The blank self-emulsified system was composed of ethyl oleate/Cremophor EUL/butanol with weight ratio of 10: 54: 36. After being dilutied with water, the morphology of microemulsion was homogeneous small spherical drops observed under the electro-microscopy. The particle size and the zeta potential were 16.3 +/- 4.6 nm and 2.1 +/- 0.8 mV, respectively. The solubility of quercetin in self-emulsifing system was (62.42 +/- 0.11) mg x mL(-1), increased 2 229 folds compared with that of in water. The quality of quercetin self-emulsified formulation was stable during the 3 months storage at 40 degrees C.
  
  
  CONCLUSIONS
  The solubility of quercetin is significantly increased in self-emulsified system and the formulation is stable and easy to prepare.
authors.affiliation: Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo 315100, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Chen
authors.forename: Wen-Quan
authors.initials: WQ
authors.lastname: Liang
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry; D000440:Butanols / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems; D004355:Drug Stability; D004655:Emulsions; D005990:Glycerol / Q000031:analogs & derivatives / Q000737:chemistry; D009829:Oleic Acids / Q000737:chemistry; D010316:Particle Size; D011794:Quercetin / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D012997:Solvents; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000975:Antioxidants; D000440:Butanols; D004655:Emulsions; D009829:Oleic Acids; D012997:Solvents; C000515:cremophor EL; D011794:Quercetin; D005990:Glycerol; C033180:ethyl oleate