[Coating with plasma-deposited functionalized diamond-like carbon to decrease encrustations on urological implants].
The double-J stents used today for palliative artificial urinary diversion very often show extreme formation of encrustations, even a short time after implantation. Despite increased scientific material development, the complication rate has not really been strongly influenced. Grant-aided by the German Federal Ministry of Education and Research, we chose a new interdisciplinary and translational approach by coating standard stent materials with plasma-deposited amorphous diamond-like carbon. These stents show clearly reduced rates of encrustation in vitro. Ongoing clinical trials demonstrate a further enhancement of this effect in vivo. The underlying mechanisms are being investigated by extending the established in vitro model, thereby pushing research in this field to a new level.
Laube
N
N
Klinik und Poliklinik für Urologie, Universitätsklinikum, Sigmund-Freud-Strasse 25, 53125 Bonn. norbert.laube@ukb.uni-bonn.de
Kleinen
L
L
Böde
U
U
Fisang
C
C
Meissner
A
A
Bradenahl
J
J
Syring
I
I
Busch
H
H
Pinkowski
W
W
Müller
S C
SC
D000818:Animals; D018441:Biofilms / Q000254:growth & development*; D002244:Carbon; D020099:Coated Materials, Biocompatible; D003460:Crystallization; D019276:Glycocalyx; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver; D008422:Materials Testing; D010710:Phosphates; D010949:Plasma; D011140:Polyurethanes; D019736:Prostheses and Implants; D015607:Stents; D013552:Swine; D014547:Urinary Diversion / Q000295:instrumentation*; D014556:Urine
D020099:Coated Materials, Biocompatible; D010710:Phosphates; D011140:Polyurethanes; D002244:Carbon