Tumor suppression by DNA base excision repair.
Base excision repair (BER) is the main pathway for repair of endogenous DNA damage. It was expected that different tumor types could derive from BER defects but to date this link is elusive. In vitro and molecular epidemiology studies may be used to unravel this issue.
Frosina
G
G
Department of Translational Oncology, Experimental Oncology B Laboratory, Istituto Nazionale Ricerca Cancro, Genova, Italy. guido.frosina@istge.it
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D051379:Mice; D017720:Molecular Epidemiology; D009154:Mutation; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D013489:Suppression, Genetic