title: Small-vessel vascular disease in human immunodeficiency virus infection: the Hawaii aging with HIV cohort study.
abstract: BACKGROUND
  This study is designed to determine the relationship between age and occurrence of cerebral manifestations of small-vessel ischemic vascular disease in human immunodeficiency virus (HIV)-seropositive individuals.
  
  
  METHODS
  Periventricular leukoaraiosis severity and white matter lesion volume were determined by magnetic resonance imaging of the brain of 57 HIV-seropositive individuals.
  
  
  RESULTS
  Cerebral small-vessel ischemic vascular disease manifestations correlated with age and systolic blood pressure, but not with HIV infection-related parameters.
  
  
  CONCLUSIONS
  These findings suggest that, in the era of highly active antiretroviral therapy, leukoaraiosis severity and white matter lesion volume may be more indicative of small-vessel ischemic vascular disease than HIV-related CNS pathology, and support the need for aggressive treatment of vascular risk factors in HIV-seropositive individuals.
authors.affiliation: Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA. aaronmnm@hawaii.edu
authors.forename: Aaron
authors.initials: A
authors.lastname: McMurtray
authors.forename: Beau
authors.initials: B
authors.lastname: Nakamoto
authors.forename: Cecelia
authors.initials: C
authors.lastname: Shikuma
authors.forename: Victor
authors.initials: V
authors.lastname: Valcour
mesh_terms: D015526:AIDS Dementia Complex / Q000209:etiology / Q000473:pathology / Q000821:virology; D000328:Adult; D000367:Age Factors; D000375:Aging / Q000473:pathology*; D001794:Blood Pressure; D002545:Brain Ischemia / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D002536:Cerebral Arteries / Q000473:pathology* / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D006679:HIV Seropositivity / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006254:Hawaii; D006801:Humans; D049292:Leukoaraiosis / Q000150:complications / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index