Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis.
The authors assessed the gene polymorphisms of missense C/T polymorphism in exon 6 of the urokinase-plasminogen activator (PLAU) gene (PLAU P141L), Alu-repeat in intron 8 of the tissue-type plasminogen activator (PLAT) gene (PLAT TPA25 Alu insertion), and 4G/5G in the promoter region of the serine proteinase inhibitor, clade E (SERPINE) or plasminogen activator inhibitor type 1 gene (SERPINE1 -675 4G/5G) in 153 healthy volunteers and 154 retired coal miners with coal miners' pneumoconiosis (CWP). The CWP subjects included 94 individuals with simple pneumoconiosis and 60 individuals with progressive massive fibrosis presenting with worse pulmonary function. The distributions of genotypes of these three genes did not differ between the control and CWP subjects or between subjects with simple pneumoconiosis and those with progressive massive fibrosis. However, by assessing duration of work and its interaction with genotypes by means of logistic regression, the authors found the missense C/T polymorphism in exon 6 of the PLAU gene to be an effect modifier of the association between work duration and the development of progressive massive fibrosis.
Chang
Liang-Che
LC
Department of Pathology, Chang Gung Memorial Hospital, Keelung and Chang Gung University, Keelung, Taiwan, Republic of China.
Tseng
Jo-Chi
JC
Hua
Chung-Ching
CC
Liu
Yu-Chih
YC
Shieh
Wen-Bin
WB
Wu
Huang-Pin
HP
D000368:Aged; D003032:Coal Mining; D004798:Enzymes / Q000096:biosynthesis / Q000235:genetics*; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1; D011009:Pneumoconiosis / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics*; D013624:Taiwan; D010959:Tissue Plasminogen Activator
D004798:Enzymes; D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator