Robust gammadelta+ T cell expansion in infants immunized at birth with BCG vaccine.
Cell-mediated immune responses to BCG vaccine were evaluated in 7-month-old infants vaccinated with intradermal combined BCG and Hepatitis B or intradermal BCG and intramuscular Hepatitis B at birth. Peripheral blood mononuclear cell cultures from both groups showed CD4(+), CD8(+) and remarkable gammadelta(+) T cell BCG-specific proliferation, without significant differences. Also, IL-10, IL-12, IFN-gamma and TNF-alpha concentrations in culture supernatants, measured by ELISA, were similar. The results suggested that the combined BCG and Hepatitis B vaccine was as immunogenic as BCG separated from Hepatitis B vaccine.
Mazzola
T N
TN
Center of Investigation in Pediatrics, Pediatrics Department, State University of Campinas Medical School, Campinas, São Paulo, Brazil. tanmazzola@yahoo.com.br
Da Silva
M T N
MT
Moreno
Y M F
YM
Lima
S C B S
SC
Carniel
E F
EF
Morcillo
A M
AM
Antonio
M A R G M
MA
Zanolli
M L
ML
Netto
A Aranha
AA
Blotta
M H
MH
Raw
I
I
Vilela
M M S
MM
D001500:BCG Vaccine / Q000276:immunology*; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007223:Infant; D007231:Infant, Newborn; D008213:Lymphocyte Activation; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology*; D017778:Vaccines, Combined / Q000276:immunology
D001500:BCG Vaccine; D016207:Cytokines; D017325:Hepatitis B Vaccines; D016692:Receptors, Antigen, T-Cell, gamma-delta; D017778:Vaccines, Combined