Inoculation of Chlamydia pneumoniae or Chlamydia trachomatis with ligands that inhibit attachment to host cells reduces infectivity in the mouse model of lung infection: implication for anti-adhesive therapy.
Previous studies have shown that the chlamydial glycan contains a high-mannose oligosaccharide, which mediates attachment and infectivity of the organism. Removal of the glycan decreases infectivity in vitro and in vivo. The present study demonstrates that simultaneous inoculation of chlamydial organisms and a ligand that prevents glycan binding reduces lung burden in infected animals.
Kuo
Cho-Chou
CC
Department of Pathobiology, Box 357238, University of Washington School of Public Health and Community Medicine, Seattle, WA 98195-7238, USA. cckuo@u.washington.edu
Lee
Amy
A
Jiang
Shinn-Jong
SJ
Yaraei
Kambiz
K
Campbell
Lee Ann
LA
D000180:Acrylic Resins / Q000494:pharmacology; D000818:Animals; D001287:Attachment Sites, Microbiological / Q000187:drug effects; D001422:Bacterial Adhesion / Q000187:drug effects; D002690:Chlamydia Infections / Q000378:metabolism* / Q000382:microbiology / Q000517:prevention & control; D002692:Chlamydia trachomatis / Q000378:metabolism* / Q000472:pathogenicity; D016993:Chlamydophila pneumoniae / Q000378:metabolism* / Q000472:pathogenicity; D008024:Ligands; D008168:Lung / Q000382:microbiology*; D008171:Lung Diseases / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control; D008351:Mannans / Q000494:pharmacology; D008358:Mannose / Q000378:metabolism; D051379:Mice; D023421:Models, Animal; D009844:Oligosaccharides / Q000378:metabolism; D018410:Pneumonia, Bacterial / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control; D017527:Receptor, IGF Type 2 / Q000378:metabolism; D000099166:Polyacrylamides
D000180:Acrylic Resins; D008024:Ligands; D008351:Mannans; D008358:Mannose; D009844:Oligosaccharides; D017527:Receptor, IGF Type 2; D000099166:Polyacrylamides