Interaction profiling of T-cell epitopes with MHC-class I molecules.
A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We report a structural bioinformatics study of peptide-HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.
Dash
Banaja Priyardarshini
BP
Bioinformatics Centre and Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore, India.
Mukherjee
Sumanto
S
Suhas
V L
VL
Chandra
Nagasuma
N
D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D018604:Epitope Mapping / Q000379:methods; D018984:Epitopes, T-Lymphocyte / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D025941:Protein Interaction Mapping
D018984:Epitopes, T-Lymphocyte; D015395:Histocompatibility Antigens Class I; D010455:Peptides