[Changes in pharmacokinetic parameters of vancomycin in the subeschar tissue fluid in patients with severe burns].
OBJECTIVE
To investigate the changes in pharmacokinetic parameters of vancomycin in the subeschar tissue fluid (STF) at early post-burn stage in patients with severe burns.


METHODS
Ten patients with severe burns were enrolled in the study and received intravenous injection of 500 mg vancomycin at an even rate within 60 mins 1 to 2 hours after admission. A total of 0.5 ml STF was collected each time and the concentration of vancomycin in the STF was determined by fluorescence polarization immunoassay (FPIA) method at 1, 2, 4, 8, 24, 48, 96, 144, 192, 240 post-burn hours (PBH). Pharmacokinetic parameters of vancomycin were produced by program 3P97 and statistically analyzed by program package SPSS10. 0.


RESULTS
The STF concentration-time curves of vancomycin were best fit in two compartment model. Pharmacokinetic parameters of vancomycin in the STF were: t1/2alpha = (3.7 +/- 2.6) h, t1/2beta = (92 +/- 12)h, Vc = (26 +/- 6)L, AUC = (1279 +/- 256) microg x h x ml(-1), CLs = (0.40 +/- 0.08) L/h.


CONCLUSIONS
When vancomycin is used early after severe burns, the drug can be retained in the third space, and the concentration of the drug can be maintained for over 24hrs, and it is beneficial to form an antibiotic barrier around the wound to prevent an invasive bacterial infection to the burn wound.
Yang
Rong-Hua
RH
Department of Burns, the First Municipal Hospital of Guangzhou, Guangzhou Medical College, Guangzhou 510180, P. R. China.
Rong
Xin-Zhou
XZ
Zhang
Tao
T
Hua
Rong
R
D000328:Adult; D002056:Burns / Q000188:drug therapy / Q000378:metabolism*; D005122:Exudates and Transudates / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D014640:Vancomycin / Q000493:pharmacokinetics* / Q000627:therapeutic use
D014640:Vancomycin