Delivery of superparamagnetic nanoparticles for local chemotherapy after intraarterial infusion and magnetic drug targeting.
BACKGROUND
Superparamagnetic nanoparticles are currently used as contrast agents for magnetic resonance imaging. These particles can also be used as drug carriers for local chemotherapy, called magnetic drug targeting. Using an external magnetic field, colloidal nanoparticles can be directed to a specific body compartment (i.e. tumor).


METHODS
After magnetic drug targeting in an experimental rabbit model with a VX2 squamous cell carcinoma, tumor tissue was extracted and embedded in paraffin for histology and X-ray imaging.


RESULTS
The distribution of magnetic nanoparticles was detected holistically with X-ray imaging and in detail using Prussian blue staining of histological cross sections.


CONCLUSIONS
The biodistribution of magnetic nanoparticles can be visualized with X-ray imaging and histologically confirmed.
Alexiou
Christoph
C
Department of Otorhinolaryngology, Head and Neck Surgery, University Erlangen-Nürnberg, Germany. C.Alexiou@web.de
Jurgons
Roland
R
Seliger
Christian
C
Brunke
Oliver
O
Iro
Heinrich
H
Odenbach
Stefan
S
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000188:drug therapy; D016503:Drug Delivery Systems / Q000379:methods*; D007261:Infusions, Intra-Arterial; D008280:Magnetics; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011817:Rabbits; D011859:Radiography; D014018:Tissue Distribution; D014965:X-Rays