The spirastrellolides: construction of the southern C(1)-C(25) fragment exploiting anion relay chemistry.
Effective construction of the southern C(1)-C(25) fragment of spirastrellolide A has been achieved. Central to this venture was the use of four dithiane unions, including the highly effective deployment of the anion relay chemistry (ARC) tactic recently introduced by our laboratory.
Smith
Amos B
AB
Department of Chemistry, Monell Chemical Senses Center, and Laboratory for Research on Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. smithab@sas.upenn.edu
Kim
Dae-Shik
DS
D000818:Animals; D000838:Anions; D018942:Macrolides / Q000138:chemical synthesis*; D011161:Porifera / Q000737:chemistry; D011807:Quinolizines / Q000737:chemistry; D013141:Spiro Compounds; D013457:Sulfur Compounds / Q000737:chemistry
D000838:Anions; D018942:Macrolides; D011807:Quinolizines; D013141:Spiro Compounds; D013457:Sulfur Compounds; C438055:dithiane; C475125:spirastrellolide A