title: The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention.
abstract: The mammalian target of rapamycin (mTOR) is a key signaling node coordinating cell cycle progression and cell growth in response to genetic, epigenetic, and environmental conditions. Pathways involved in mTOR signaling are dysregulated in precancerous human tissues. These findings, together with the intriguing possibility that mTOR suppression may be associated with antitumor actions of caloric restriction, suggest that mTOR signaling may be an important target for chemopreventive drugs.
authors.affiliation: Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. lk94c@nih.gov
authors.forename: Levy
authors.initials: L
authors.lastname: Kopelovich
authors.forename: Judith R
authors.initials: JR
authors.lastname: Fay
authors.forename: Caroline C
authors.initials: CC
authors.lastname: Sigman
authors.forename: James A
authors.initials: JA
authors.lastname: Crowell
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018890:Chemoprevention; D002986:Clinical Trials as Topic; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011494:Protein Kinases / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases