Aphthous ulcerations associated with trisomy 8-positive myelodysplastic syndrome.
The association of Behçet's disease with myelodysplastic syndromes has been established in the hematologic, gastrointestinal, and medical genetics literature; trisomy 8 is a feature present in 70% of these reports. Because trisomy 8 is ordinarily present in only 14% of patients with myelodysplastic syndrome, this is a significant overrepresentation. We describe a patient with recurrent aphthous stomatitis who was subsequently diagnosed with trisomy 8-positive myelodysplastic syndrome after an unexplained macrocytosis was further investigated.
Fine
Lauren A
LA
Department of Dermatology, Rush University, Chicago, Illinois, IL 60612, USA.
Hoffman
Laura D
LD
Hoffman
Mark D
MD
D000328:Adult; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics*; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000209:etiology*; D014314:Trisomy