title: The association between plasma levels of acute phase proteins, haptoglobin, alpha-1 acid glycoprotein (AGP), pig-MAP, transthyretin and serum amyloid A (SAA) in Large White and Meishan pigs.
abstract: During infection, the acute phase response triggers the release of acute phase proteins (APP), alpha-(1) acid glycoprotein (AGP), serum amyloid A (SAA) and Pig-MAP into the circulation, accompanied by a decrease in plasma levels of transthyretin. We quantified the association between these APP in 26 apparently healthy pigs from two breeds, 13 Large White and 13 Meishan (16 male; 10 female). There was a significant correlation between plasma levels of haptoglobin and Pig-MAP (r=0.57; p<0.05), but no significant associations between any of the other APP tested. We also measured the relationship between PigMAP, transthyretin and SAA, and the proportions of peripheral blood mononuclear sub-sets, CD8(+) cells, CD4(+) cells, CD11R1(+) cells, MHC DQ(+) cells, and monocytes. There were correlations between both plasma levels of Pig-MAP and the proportion of monocytes (r=0.55; p<0.05) and plasma levels of transthyretin and the proportion of MHC DQ(+) cells (r=0.40; p<0.01). Breed and sex influenced plasma levels of Pig-MAP but not plasma levels of transthyretin. Overall, these results suggest closer links between the mechanisms that regulate the release haptoglobin, Pig-MAP and monocytes compared to those that regulate the release of AGP, SAA and transthyretin.
authors.affiliation: Genetics and Genomics, Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS, UK. Mary.Clapperton@bbsrc.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Clapperton
authors.forename: S C
authors.initials: SC
authors.lastname: Bishop
authors.forename: M
authors.initials: M
authors.lastname: Piñeiro
authors.forename: F M
authors.initials: FM
authors.lastname: Campbell
authors.forename: E J
authors.initials: EJ
authors.lastname: Glass
mesh_terms: D000209:Acute-Phase Proteins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D005260:Female; D006242:Haptoglobins / Q000378:metabolism*; D008297:Male; D009961:Orosomucoid / Q000378:metabolism*; D011228:Prealbumin / Q000378:metabolism*; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D013552:Swine / Q000097:blood* / Q000145:classification / Q000276:immunology
chemical_list: D000209:Acute-Phase Proteins; D006242:Haptoglobins; D009961:Orosomucoid; D011228:Prealbumin; D000685:Serum Amyloid A Protein; C095815:ITIH4 protein, Sus scrofa