title: Chuktabularins A-D, four new limonoids with unprecedented carbon skeletons from the stem bark of Chukrasia tabularis.
abstract: Chuktabularins A-D (1-4), four novel 16-norphragmalin-type limonoids that feature unprecedented skeletons with a biosynthetically extended C2 or C3 unit at C-15 forming a unique 2,7-dioxabicyclo[2.2.1]heptane moiety, were isolated from the stem bark of Chukrasia tabularis. Their structures were elucidated by spectroscopic analysis and computer modeling. The biosynthetic pathway of 1-4 was postulated.
authors.affiliation: State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Chuan-Rui
authors.initials: CR
authors.lastname: Zhang
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Yang
authors.forename: Shang-Gao
authors.initials: SG
authors.lastname: Liao
authors.forename: Cheng-Qi
authors.initials: CQ
authors.lastname: Fan
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D053898:Biosynthetic Pathways; D036701:Limonins / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*
chemical_list: D036701:Limonins