title: Effects of smoking cessation on coronary endothelial function in patients with recent myocardial infarction.
abstract: BACKGROUND
  Smoking is associated with an increased risk and extent of advanced atherosclerotic vascular disease, but few studies have examined the clinical effect of smoking cessation on human coronary endothelial function.
  
  
  OBJECTIVE
  We sought to determine the effects of smoking cessation on endothelial function in patients with recent myocardial infarction.
  
  
  METHODS
  Infarcted-not-related coronary arteries of 53 patients with acute myocardial infarction undergoing successful angioplasty were examined in two groups: smoking cessation group (n=35, 28 males, mean age 56 years) and non-smoking group (n=18, 10 males, mean age 65 years). We infused acetylcholine into the coronary artery and the diameter was assessed by quantitative angiography at baseline and 6 months after PTCA.
  
  
  RESULTS
  The mean % diameter change from baseline was significantly more constricted in the smoking cessation group than in the non-smoking group (38%+/-5 vs. 19%+/-5, p<0.05). However, the response after six months was significantly decreased after smoking cessation (from 38%+/-5 to 28%+/-4, p<0.01). Multiple regression analysis showed smoking cessation (p=0.03) was a significant determinant factor for improvement of endothelial function.
  
  
  CONCLUSIONS
  These findings suggest that just 6 months of smoking cessation improves coronary endothelial function in patients with recent myocardial infarction.
authors.affiliation: Division of Cardiology, Tokushima Red Cross Hospital, irinokuchi103, komatsushima-cho, Komatsushima-city, Tokushima 773-8502, Japan. hoso@tokushima-med.jrc.or.jp
authors.forename: Shinobu
authors.initials: S
authors.lastname: Hosokawa
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Riyo
authors.initials: R
authors.lastname: Ogura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Miyajima
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ohara
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Yuba
authors.forename: Naoki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Takefumi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Koichi
authors.initials: K
authors.lastname: Kishi
authors.forename: Ryuji
authors.initials: R
authors.lastname: Ohtani
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage; D000368:Aged; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D016009:Chi-Square Distribution; D015897:Comorbidity; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000187:drug effects* / Q000473:pathology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology; D012044:Regression Analysis; D012306:Risk; D016540:Smoking Cessation; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D002121:Calcium Channel Blockers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000109:Acetylcholine