title: The uncoupling protein-1 gene -3826A/G polymorphism and hypertension in Japanese subjects.
abstract: BACKGROUND
  The possible effects of the uncoupling protein-1 (UCP-1) gene -3826A/G polymorphism on hypertension (HT) have yet to be elucidated.
  
  
  METHODS
  A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the -3826A/G polymorphism by genomic PCR and Bcl1-restriction fragment length polymorphism methods.
  
  
  RESULTS
  Multivariate logistic regression analysis for HT, adjusted for genotype (recessive model, AA+AG vs. GG) and other covariates such as cardiovascular risk factors [e.g., smoking, body mass index (BMI), dyslipidemia and diabetes] showed age [odds ratio (OR) 1.11 (95% confidence interval 1.08-1.13)] and BMI [OR 1.13 (1.06-1.21)] as independent significant factors. In the subgroup analysis, as well as age and BMI, GG genotype [OR 2.32 (1.08-4.99)] was also an independent significant factor for HT in males. Similarly, as well as age and BMI, GG genotype [OR 1.89 (1.00-3.57)] was also an independent significant factor for HT in the relatively older subgroup (> or =60 years).
  
  
  CONCLUSIONS
  The results suggest that the GG genotype may be associated with the presence of HT in Japanese males and older subjects. Further investigation is needed to confirm our hypothesis.
authors.affiliation: Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan. kakotani@grape.med.tottori-u.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.forename: Naoki
authors.initials: N
authors.lastname: Sakane
authors.forename: Kyoko
authors.initials: K
authors.lastname: Saiga
authors.forename: Kokoro
authors.initials: K
authors.lastname: Tsuzaki
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shimohiro
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tabata
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kurozawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D007473:Ion Channels / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D012737:Sex Factors; D000071256:Uncoupling Protein 1
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1