title: Pagetoid reticulosis with CD30 positivity and cytotoxic/suppressor cells.
abstract: Pagetoid reticulosis (PR) is a low-grade primary cutaneous T-cell lymphoma that usually presents as a solitary, slowly enlarging erythematous or hyperkeratotic plaque on the distal areas of the extremities. Histopathologically, it is characterized by a dense, band-like infiltrate of atypical lymphocytes with prominent epidermotropism within a hyperplastic epidermis, and immunophenotypic studies show in most cases, a CD4-positive T-helper phenotype for the neoplastic lymphocytes. We describe an African man with a more than 20-year history of an acral lesion of PR, which was histopathologically characterized by lymphocyte immunophenotype consisting of CD8- and CD30-positive cells. We discuss the differential diagnosis with other primary cutaneous lymphoproliferative disorders showing similar immunophenotype. This case shows that CD30-positive PR should be included as a rare variant within the spectrum of CD30-positive primary cutaneous lymphoproliferative disorders. As in other primary cutaneous CD30-positive lymphoproliferative processes, lesions of CD30-positive PR show an indolent course and a benign biological behavior.
authors.affiliation: Department of Dermatology, University of Pretoria, Pretoria, South Africa.
authors.forename: Witold K
authors.initials: WK
authors.lastname: Jacyk
authors.forename: Wayne
authors.initials: W
authors.lastname: Grayson
authors.forename: Jurgen Erich
authors.initials: JE
authors.lastname: Dinkel
authors.forename: Luis
authors.initials: L
authors.lastname: Requena
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D017730:Ki-1 Antigen / Q000378:metabolism*; D008206:Lymphatic Diseases / Q000378:metabolism / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000378:metabolism / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D013602:T-Lymphocytes, Cytotoxic / Q000378:metabolism / Q000473:pathology*
chemical_list: D015415:Biomarkers; D017730:Ki-1 Antigen