title: Cadherin expression in the developing chicken cochlea.
abstract: In this study, we demonstrate that eight classic cadherins are differentially expressed in distinct anatomical regions of the cochlea during late stages of chicken embryonic development. Cadherin-6B is expressed in hair cells and spindle-shaped cells, while cadherin-8 mRNA is found only in supporting cells. Cadherin-11 is widely expressed not only in mesenchymal cell around the cochlea, but also in supporting cells and homogene cells. N-cadherin is found in the sensory epithelium, the neurons of the acoustic ganglion and on their neurites that target the hair cells. Three closely related cadherins (cadherin-7, cadherin-19, and cadherin-20) are expressed in a partially complementary manner in spindle-shaped cells and acoustic ganglion cells. R-cadherin is observed in homogene cells, acoustic ganglion cells, and their projections to hair cells. The expression of classic cadherins in the developing cochlea suggests a role for cadherins in the development of the cochlea.
authors.affiliation: Institute of Anatomy I, Friedrich Schiller University Jena, Jena, Germany. jiankai.luo@uni-rostock.de
authors.forename: Jiankai
authors.initials: J
authors.lastname: Luo
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Juntang
authors.initials: J
authors.lastname: Lin
authors.forename: Christoph
authors.initials: C
authors.lastname: Redies
mesh_terms: D000818:Animals; D015820:Cadherins / Q000235:genetics* / Q000502:physiology*; D002642:Chick Embryo; D003051:Cochlea / Q000196:embryology* / Q000254:growth & development; D018507:Gene Expression Regulation, Developmental; D012333:RNA, Messenger / Q000032:analysis; D014018:Tissue Distribution
chemical_list: D015820:Cadherins; D012333:RNA, Messenger