title: Expression of Wise in chick embryos.
abstract: We have performed in situ hybridization to study the expression of Wise in early chick embryos. Wise expression is first detectable in the ectoderm at posterior levels of late neurula. As development proceeds, Wise expression is seen in specific patterns in the ectoderm of the trunk region, pharyngeal arches, limb buds, and feather buds. In addition to these areas, particular cartilages such as the ones in the maxillary process and limbs start to express Wise at the late pharyngula stage, and the expression in these cartilages becomes stronger than that in epidermal components at later stages. Importantly, Wise is expressed in regions where other signaling molecules such as Wnt, Bmp, and Shh are known to function in morphogenesis and differentiation. Direct comparisons of the expression of Wise and these genes are also demonstrated.
authors.affiliation: Division of Developmental Neurobiology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom.
authors.forename: Y
authors.initials: Y
authors.lastname: Shigetani
authors.forename: N
authors.initials: N
authors.lastname: Itasaki
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins; D002356:Cartilage / Q000737:chemistry / Q000196:embryology; D002454:Cell Differentiation; D002642:Chick Embryo; D004475:Ectoderm / Q000737:chemistry; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D009024:Morphogenesis; D014018:Tissue Distribution; D051153:Wnt Proteins
chemical_list: D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins