Role of reactive metabolites of oxygen and nitrogen in partial liver transplantation: lessons learned from reduced-size liver ischaemia and reperfusion injury.
1. Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant number of patients develop tissue injury from these procedures, ultimately resulting in graft failure. 2. Because of this, there is a real need to understand the different mechanisms responsible for the tissue injury induced by I/R of RSL transplantation (RSL + I/R), with the ultimate goal to develop new and improved therapeutic agents that may limit the tissue damage incurred during RSL transplantation. 3. The present paper reviews the recent studies that have been performed examining the role of reactive metabolites of oxygen and nitrogen in a mouse model of RSL + I/R. In addition, we present data demonstrating how the pathophysiological mechanisms identified in this model compare with those observed in a model of RSL transplantation in rats.
Urakami
Hidejiro
H
Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, Louisiana, USA.
Abe
Yuta
Y
Grisham
Matthew B
MB
D000818:Animals; D050377:Cold Ischemia / Q000009:adverse effects*; D004195:Disease Models, Animal; D006084:Graft Rejection / Q000209:etiology* / Q000378:metabolism; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000098:blood supply* / Q000378:metabolism / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D019520:Living Donors; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D026361:Reactive Nitrogen Species / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015427:Reperfusion Injury / Q000150:complications* / Q000209:etiology / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D013997:Time Factors; D052096:Warm Ischemia / Q000009:adverse effects*
D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D013481:Superoxides; D009569:Nitric Oxide