Three-dimensional Monte Carlo simulations of intracellular diffusion and reaction of signaling proteins.
We show that the Monte Carlo technique makes it possible to perform three-dimensional simulations of intracellular protein-mediated signal transduction with realistic ratio of the rates of protein diffusion and association with genes. Specifically, we illustrate that in the simplest case when the protein degradation and phosphorylation/dephosphorylation are negligible the distribution of the first passage time for this process is close to exponential provided that the number of target genes is between 1 and 100.
Zhdanov
Vladimir P
VP
Department of Applied Physics, Chalmers University of Technology, S-41296 Göteborg, Sweden. zhdanov@catalysis.ru
D003198:Computer Simulation; D004058:Diffusion; D008954:Models, Biological; D009010:Monte Carlo Method; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
D011506:Proteins