title: Extracolonic findings in an asymptomatic screening population undergoing intravenous contrast-enhanced computed tomography colonography.
abstract: OBJECTIVE
  The purpose of this study was to evaluate extracolonic findings that could be encountered with computed tomography colonography (CTC) using intravenous (IV) contrast material in an asymptomatic screening population.
  
  
  METHODS
  Intravenous contrast medium-enhanced CTC was performed in 2230 asymptomatic adults (mean age, 57.5 years). Axial images were prospectively examined for extracolonic lesions. These findings were classified into three categories: potentially important findings, likely unimportant findings, and clinically unimportant findings. Potentially important extracolonic findings were defined as those which required immediate further diagnostic studies and treatment. Clinical and radiologic follow up, missed lesions and clinical outcomes were assessed using medical records (mean duration of follow up, 1.6 years).
  
  
  RESULTS
  A total of 115 new potentially important findings in 5.2% of subjects (115/2230) were found. Subsequent medical or surgical intervention was performed in 2.0% (45/2230). New extracolonic cancer was detected in 0.5% (12/2230), and the majority of them (83.3%) were not metastasized. Computed tomography colonography missed eight potentially important extracolonic findings in eight subjects (0.4%, 8/2230): 0.8-cm early-stage prostatic cancer, six adrenal mass and one intraductal papillary mucinous tumor. There were no severe life-threatening complications related to contrast medium.
  
  
  CONCLUSIONS
  Intravenous contrast-enhanced CTC could safely detect asymptomatic early-stage extracolonic malignant diseases without an unreasonable number of additional work-ups, thus reducing their morbidity or mortality.
authors.affiliation: Seoul National University Hospital, Healthcare System Gangnam Center, Healthcare Research Institute Seoul, Korea.
authors.forename: Young Sun
authors.initials: YS
authors.lastname: Kim
authors.forename: Nayoung
authors.initials: N
authors.lastname: Kim
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Kyoung Soo
authors.initials: KS
authors.lastname: Cho
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Park
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Choi
authors.forename: Seon Hee
authors.initials: SH
authors.lastname: Lim
authors.forename: Jeong Yoon
authors.initials: JY
authors.lastname: Yim
authors.forename: Kyung Ran
authors.initials: KR
authors.lastname: Cho
authors.forename: Chung Hyeon
authors.initials: CH
authors.lastname: Kim
authors.forename: Dong Hee
authors.initials: DH
authors.lastname: Kim
authors.forename: Sun Sin
authors.initials: SS
authors.lastname: Kim
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Byung Inhn
authors.initials: BI
authors.lastname: Choi
authors.forename: Hyun Chae
authors.initials: HC
authors.lastname: Jung
authors.forename: In Sung
authors.initials: IS
authors.lastname: Song
authors.forename: Chan Soo
authors.initials: CS
authors.lastname: Shin
authors.forename: Sang-Heon
authors.initials: SH
authors.lastname: Cho
authors.forename: Byung-Hee
authors.initials: BH
authors.lastname: Oh
mesh_terms: D000311:Adrenal Glands / Q000000981:diagnostic imaging; D000368:Aged; D000369:Aged, 80 and over; D001659:Biliary Tract / Q000000981:diagnostic imaging; D001808:Blood Vessels / Q000473:pathology; D003106:Colon / Q000000981:diagnostic imaging*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics; D003362:Cost-Benefit Analysis; D042241:Early Diagnosis; D004947:Esophagus / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000000981:diagnostic imaging; D008099:Liver / Q000000981:diagnostic imaging; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008403:Mass Screening / Q000191:economics / Q000379:methods*; D008499:Medical Records; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D010179:Pancreas / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013270:Stomach / Q000000981:diagnostic imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000191:economics; D014566:Urogenital System / Q000473:pathology
chemical_list: D003287:Contrast Media