title: New iron chelators in anthracycline-induced cardiotoxicity.
abstract: The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote anthracycline-induced oxidative stress. Aroylhydrazone lipophilic iron chelators have shown promising results in the rabbit model of daunorubicin-induced cardiomyopathy as well as in cellular models. The lack of interference with the antiproliferative effects of the anthracyclines also favors their use in clinical settings. The dose, however, should be carefully titrated to prevent iron depletion, which apparently also applies for other strong iron chelators. We have shown that a mere ability of a compound to chelate iron is not the sole determinant of a good cardioprotector and the protective potential does not directly correlate with the ability of the chelators to prevent hydroxyl radical formation. These findings, however, do not weaken the role of iron in doxorubicin cardiotoxicity as such, they rather appeal for further investigations into the molecular mechanisms how anthracyclines interact with iron and how iron chelation may interfere with these processes.
authors.affiliation: Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic. kaiserova@uochb.cas.cz
authors.forename: Helena
authors.initials: H
authors.lastname: Kaiserová
authors.forename: Tomás
authors.initials: T
authors.lastname: Simunek
authors.forename: Martin
authors.initials: M
authors.lastname: Sterba
authors.forename: Gertjan J M
authors.initials: GJ
authors.lastname: den Hartog
authors.forename: Ladislava
authors.initials: L
authors.lastname: Schröterová
authors.forename: Olga
authors.initials: O
authors.lastname: Popelová
authors.forename: Vladimír
authors.initials: V
authors.lastname: Gersl
authors.forename: Eva
authors.initials: E
authors.lastname: Kvasnicková
authors.forename: Aalt
authors.initials: A
authors.lastname: Bast
mesh_terms: D000818:Animals; D018943:Anthracyclines / Q000009:adverse effects / Q000633:toxicity*; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000633:toxicity*; D002316:Cardiotonic Agents; D006331:Heart Diseases / Q000139:chemically induced* / Q000378:metabolism* / Q000517:prevention & control; D006801:Humans; D007501:Iron / Q000502:physiology*; D007502:Iron Chelating Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D002316:Cardiotonic Agents; D007502:Iron Chelating Agents; D007501:Iron