title: Remodeling chromatin for senescence.
abstract: Cellular senescence is an irreversible proliferation arrest that contributes to tumor suppression and, perhaps, tissue aging. Senescence is frequently accompanied by an increase in nuclear heterochromatin, which is thought to promote proliferation arrest. In this issue, Medrano and co-workers describe new insights into the protein complexes that regulate these changes in chromatin structure.
authors.affiliation: Fox Chase Cancer Center, Philadelphia, PA 19111, USA. peter.adams@fccc.edu
authors.forename: Peter D
authors.initials: PD
authors.lastname: Adams
mesh_terms: D000375:Aging / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology*; D002877:Chromosomes, Human / Q000502:physiology*; D024003:HMGA Proteins / Q000378:metabolism; D006570:Heterochromatin / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D024003:HMGA Proteins; D006570:Heterochromatin; D006657:Histones; C084011:SMARCA2 protein, human; D014157:Transcription Factors