title: C-geranyl compounds from Paulownia tomentosa fruits.
abstract: Five geranylflavonoids, one prenylated flavonoid, and a simple flavanone were isolated from an ethanolic extract of Paulownia tomentosa fruit. Tomentodiplacol (1), 3'-O-methyl-5'-methoxydiplacol (2), 6-isopentenyl-3'-O-methyltaxifolin (3), and dihydrotricin (4) are reported from a natural source for the first time and 3'-O-methyldiplacone (6) for the first time from the genus Paulownia. The structures of the compounds were determined by mass spectrometry, including HRMS, and by 1D and 2D NMR spectroscopy. The cytotoxicity and DPPH (2,2-diphenyl-1-picrylhydrazyl)-quenching activity of some of these compounds were tested, with diplacone proving to be the best antioxidant, although the most cytotoxic compound.
authors.affiliation: Department of Natural Drugs, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, CZ-612 42 Brno, Czech Republic. karel.mejkal@post.cz
authors.forename: Karel
authors.initials: K
authors.lastname: Smejkal
authors.forename: Lenka
authors.initials: L
authors.lastname: Grycová
authors.forename: Radek
authors.initials: R
authors.lastname: Marek
authors.forename: Filip
authors.initials: F
authors.lastname: Lemière
authors.forename: Dagmar
authors.initials: D
authors.lastname: Jankovská
authors.forename: Hana
authors.initials: H
authors.lastname: Forejtníková
authors.forename: Ján
authors.initials: J
authors.lastname: Vanco
authors.forename: Václav
authors.initials: V
authors.lastname: Suchý
mesh_terms: D001713:Biphenyl Compounds; D018153:Czech Republic; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D028083:Scrophulariaceae / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; D005419:Flavonoids; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl