title: Dopamine transporter SPECT of a liver cirrhotic with atypical parkinsonism.
abstract: High level of exposure to manganese (Mn) can cause a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of [123I]-fluoropropyl (FP)-CIT SPECT of a liver cirrhotic with atypical parkinsonism. The patient developed atypical parkinsonian features associated with elevated blood Mn from hepatic dysfunction. [123I]-FP-CIT brain SPECT images of dopamine transporter (DAT) demonstrated overall normal range of DAT uptake in the striatum although there were scattered small hypodense regions. The globus pallidum had increased signal on T1-weighted magnetic resonance imaging (MRI). All these findings are compatible with those of manganism, and are remarkably different from that in PD.
authors.affiliation: Department of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, South Korea.
authors.forename: Jongchul
authors.initials: J
authors.lastname: Kim
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Yu Kyeong
authors.initials: YK
authors.lastname: Kim
authors.forename: Jung Woo
authors.initials: JW
authors.lastname: Shin
authors.forename: Seong Hoon
authors.initials: SH
authors.lastname: Choi
authors.forename: Sang Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Yangho
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D050483:Dopamine Plasma Membrane Transport Proteins; D005917:Globus Pallidus; D006801:Humans; D008103:Liver Cirrhosis; D008297:Male; D008345:Manganese / Q000633:toxicity*; D020734:Parkinsonian Disorders / Q000175:diagnosis* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D008345:Manganese