title: Lactic acidosis after treatment with linezolid.
abstract: Linezolid is currently indicated to treat vancomycin-resistant Enterococcus faecium infections, nosocomial pneumonia caused by Staphylococcus aureus or Streptococcus pneumoniae, complicated and uncomplicated skin and skin structure infections, and community-acquired pneumonia. We report a case of linezolid-induced lactic acidosis during treatment of vancomycin-resistant enterococcal bacteremia after mitral valve replacement and permanent pacemaker implantation. We also review the current literature describing other cases of linezolid-associated hyperlactatemia.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA. mwiener@montefiore.org
authors.forename: M
authors.initials: M
authors.lastname: Wiener
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.forename: G
authors.initials: G
authors.lastname: Patel
authors.forename: B C
authors.initials: BC
authors.lastname: Fries
mesh_terms: D000081:Acetamides / Q000009:adverse effects*; D000140:Acidosis, Lactic / Q000139:chemically induced*; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D016983:Enterococcus / Q000187:drug effects; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D000069349:Linezolid; D023303:Oxazolidinones / Q000009:adverse effects*; D020713:Vancomycin Resistance / Q000187:drug effects*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid