[Molecular principles of alternative treatment approaches for hormone-refractory prostate cancer].
Prostate cancer is more frequently diagnosed in men from Western countries than from Asian societies. Therefore, nutritional factors such as phyto-oestrogens from soya are considered to cause this prostate cancer prevention effect. As there is no curative therapy for hormone-refractory prostate cancer, new strategies are in demand which might include phyto-oestrogens or inhibitors of histone deacetylases. Both approaches have in common the potential to reduce the aberrant androgen receptor and IGF receptor signalling. Furthermore, invasiveness and acquired survival strategies of tumours can be diminished. Reduced tumour cell proliferation and PSA secretion coincide with altered gene expression in the aforementioned processes. In addition, selective knock-down of genes by RNA interference afforded functional analyses regarding impact and succession of expression events involved in the beneficial effects caused by phyto-oestrogens and histone deacetylase inhibitors.
Thelen
P
P
Urologische Klinik, Georg-August-Universität, Robert-Koch-Strasse 40, 37075 Göttingen. pthelen@gwdg.de
Burfeind
P
P
Schweyer
S
S
Scharf
J-G
JG
Wuttke
W
W
Ringert
R-H
RH
D014408:Biomarkers, Tumor / Q000235:genetics; D002455:Cell Division / Q000187:drug effects / Q000235:genetics; D000529:Complementary Therapies; D015870:Gene Expression / Q000187:drug effects; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D008297:Male; D048789:Phytoestrogens / Q000627:therapeutic use*; D008517:Phytotherapy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000628:therapy*; D034741:RNA, Small Interfering / Q000235:genetics; D011944:Receptors, Androgen / Q000187:drug effects / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
D014408:Biomarkers, Tumor; D056572:Histone Deacetylase Inhibitors; D048789:Phytoestrogens; D034741:RNA, Small Interfering; D011944:Receptors, Androgen