title: Micronized diosmin (Detralex) for vein-related trophic ulcers: European experience.
abstract: The paper presents a meta-analysis of 5 large European studies (N - 723) on the micronized diosmin administration to patients with venous trophic ulcers (CEAP class VI). With the use of evidence-based approach, it was shown that micronized diosmin has a statistically significant clinical effect on middle-sized trophic ulcers (5 - 10 cm(2)) that persisted for 6 - 12 months. The study concludes that polyvalent venotonics are an appropriate and valuable addition to complex therapy of complicated chronic venous insufficiency.
authors.affiliation: Chair of Faculty Surgery, Department of Continuing Education, Russian State Medical University, Moscow A V Vishnevsky Institute of Surgery, RAMS, Moscow, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Savel'ev
authors.forename: A V
authors.initials: AV
authors.lastname: Pokrovskiĭ
authors.forename: S V
authors.initials: SV
authors.lastname: Sapelkin
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Bogachev
authors.forename: L I
authors.initials: LI
authors.lastname: Bogdanets
authors.forename: I A
authors.initials: IA
authors.lastname: Zolotukhin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000188:drug therapy / Q000503:physiopathology; D004145:Diosmin / Q000627:therapeutic use*; D005060:Europe; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy* / Q000473:pathology; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D014647:Varicose Ulcer / Q000188:drug therapy / Q000473:pathology
chemical_list: D004145:Diosmin