Medium-sized carbocycles by a zirconocene-catalyzed tandem formal ring expansion-magnesation reaction of alkenyl-substituted cyclic enol ethers.
A new regio- and stereoselective zirconocene-catalyzed reaction for the synthesis of medium-sized rings is described. The global reaction supposes a formal ring expansion of a cyclic enol ether to give a functionalized carbocycle.
Barluenga
José
J
Instituto Universitario de Química OrganometAlica Enrique Moles, Unidad Asociada al CSIC, Universidad de Oviedo, JuliAn Clavería 8, 33006-Oviedo, Spain. barluenga@uniovi.es
Alvarez-Rodrigo
Lucía
L
Rodríguez
Félix
F
Fañanás
Francisco J
FJ
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D004988:Ethers, Cyclic / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry*
D000475:Alkenes; D004988:Ethers, Cyclic; D009942:Organometallic Compounds; C023398:Zirconocene dichloride; D015040:Zirconium; D008274:Magnesium