Relation of admission white blood cell count to left ventricular remodeling after anterior wall acute myocardial infarction.
We investigated whether a high white blood cell (WBC) count on admission for acute myocardial infarction (AMI) may be associated with a higher risk of subsequent left ventricular (LV) remodeling. We included 107 patients with anterior AMI. Echocardiographic studies were performed at hospital discharge, at 3 months, and at 1 year after AMI. LV remodeling (>20% increase in end-diastolic volume) was observed in 27% of patients. WBC counts during hospitalization were higher in patients who subsequently underwent LV remodeling (p = 0.003 for WBC count on admission). The increase in end-diastolic volume from baseline to 1 year was greater for patients in the higher tertile of WBC count on admission (p = 0.04). When adjusting for baseline clinical and echocardiographic characteristics by multivariate analysis, WBC count on admission was independently associated with LV remodeling (odds ratio 1.23, 95% confidence interval 1.04 to 1.45, p = 0.018). In conclusion, a high WBC count on admission for AMI is an independent predictor of LV remodeling, even when predischarge echocardiographic variables are taken into account.
Bauters
Anne
A
Centre Hospitalier Régional et Universitaire de Lille, Lille, France.
Ennezat
Pierre V
PV
Tricot
Olivier
O
Lallemant
Robert
R
Aumégeat
Valérie
V
Segrestin
Benoit
B
Quandalle
Philippe
P
Lamblin
Nicolas
N
Bauters
Christophe
C
D003955:Diagnostic Tests, Routine; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000503:physiopathology*; D020257:Ventricular Remodeling / Q000502:physiology*