title: Repairing defect and preventing collapse of canine femoral head using titanium implant enhanced by autogenous bone graft and rhBMP-2.
abstract: There is a direct relationship between mechanical stress and the progressive collapse of the necrotic region in osteonecrosis of the femoral head. The titanium implant combined with autogenous bone graft and recombinant human bone morphogenetic protein (rhBMP)-2 to repair the defect and prevent collapse of the femoral head was investigated. The femoral head defects were made by the trapdoor procedure and then the defects were filled, respectively, with the titanium implant combined with autogenous bone graft and rhBMP-2, with autogenous bone graft and rhBMP-2, and with autogenous bone graft alone. Roentgenographic and histological examinations were performed at various times postoperatively. The defects were repaired completely and the titanium implant was integrated with the surrounding bone tissues. The defects healed faster than did without rhBMP-2. No trapdoor cartilage collapsed and joint space narrowed. The titanium implant combined with autogenous bone graft and rhBMP-2 can enhance the repairing procedure and prevent the collapse of the femoral head.
authors.affiliation: Orthopaedic Department, West China Hospital of Sichuan University, Chengdu, P.R. China.
authors.forename: Pengde
authors.initials: P
authors.lastname: Kang
authors.forename: Bin
authors.initials: B
authors.lastname: Shen
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Jingqiu
authors.initials: J
authors.lastname: Cheng
authors.forename: Fuxing
authors.initials: F
authors.lastname: Pei
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002358:Cartilage, Articular / Q000187:drug effects / Q000473:pathology; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D005271:Femur Head Necrosis / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D020007:Implants, Experimental; D008297:Male; D016348:Osseointegration; D019919:Prosthesis Implantation; D011994:Recombinant Proteins / Q000627:therapeutic use*; D014025:Titanium; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D014025:Titanium