Lysosome-related organelles: driving post-Golgi compartments into specialisation.
Some cells harbour specialised lysosome-related organelles (LROs) that share features of late endosomes/lysosomes but are functionally, morphologically and/or compositionally distinct. Ubiquitous trafficking machineries cooperate with cell type specific cargoes to produce these organelles. Several genetic diseases are caused by dysfunctional LRO formation and/or motility. Many genes affected by these diseases have been recently identified, revealing new cellular components of the trafficking machinery. Current research reveals how the products of these genes cooperate to generate LROs and how these otherwise diverse organelles are related by the mechanisms through which they form.
Raposo
Graça
G
Institut Curie, Centre de Recherche, Paris F-75248, France. graca.roposo@curie.fr
Marks
Michael S
MS
Cutler
Daniel F
DF
D000818:Animals; D002451:Cell Compartmentation / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism; D006056:Golgi Apparatus / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000502:physiology*; D020460:Melanosomes / Q000502:physiology; D015388:Organelles / Q000502:physiology*; D021382:Protein Sorting Signals; D020691:rab GTP-Binding Proteins / Q000502:physiology; D000075745:rab27 GTP-Binding Proteins
D021382:Protein Sorting Signals; D000075745:rab27 GTP-Binding Proteins; C066694:RAB27A protein, human; D020691:rab GTP-Binding Proteins