[Spine biology in psychiatric diseases].
Local translation near or in spines is thought to be a molecular basis of synaptic plasticity and its abnormalities may cause psychiatric diseases. The RNA binding protein, TLS, which is identified from a screening by using a pharmacological model for schizophrenia, is translocated to dendritic spines by mGluR5 activation and regulates spine morphology. TLS facilitates transport of mRNA encoding an actin-stabilizing protein, Nd1-L, to dendritic spines. Moreover, myosin-Va is essential for the accumulation of TLS and its target RNA, Nd1-L, in dendritic spines.
Takumi
Toru
T
Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, 565 0874 Japan. takumi@obi.or.jp
D000818:Animals; D049229:Dendritic Spines / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D001523:Mental Disorders / Q000209:etiology*; D024701:Myosin Type V / Q000502:physiology; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism / Q000502:physiology; D034702:RNA-Binding Protein FUS / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology
C578935:GRM5 protein, human; C578936:Grm5 protein, mouse; D047908:Intracellular Signaling Peptides and Proteins; C432129:Nd1 protein, mouse; D011506:Proteins; D034702:RNA-Binding Protein FUS; D016601:RNA-Binding Proteins; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D024701:Myosin Type V