title: Multi-slice three-dimensional myocardial strain tensor quantification using zHARP.
abstract: In this article we propose a novel method for calculating cardiac 3-D strain. The method requires the acquisition of myocardial short-axis (SA) slices only and produces the 3-D strain tensor at every point within every pair of slices. Three-dimensional displacement is calculated from SA slices using zHARP which is then used for calculating the local displacement gradient and thus the local strain tensor. There are three main advantages of this method. First, the 3-D strain tensor is calculated for every pixel without interpolation; this is unprecedented in cardiac MR imaging. Second, this method is fast, in part because there is no need to acquire long-axis (LA) slices. Third, the method is accurate because the 3-D displacement components are acquired simultaneously and therefore reduces motion artifacts without the need for registration. This article presents the theory of computing 3-D strain from two slices using zHARP, the imaging protocol, and both phantom and in-vivo validation.
authors.affiliation: Electrical and Computer Engineering department, Johns Hopkins University, Baltimore MD 21218, USA. khaled@jhu.edu
authors.forename: Khaled Z
authors.initials: KZ
authors.lastname: Abd-Elmoniem
authors.forename: Matthias
authors.initials: M
authors.lastname: Stuber
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Prince
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D016000:Cluster Analysis; D003196:Computer Graphics; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009716:Numerical Analysis, Computer-Assisted; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D014584:User-Computer Interface