title: Simultaneous pancreas--kidney transplantation: to anticoagulate or not? Is that a question?
abstract: Pancreas graft loss due to venous thrombosis is the leading non-immunological cause for graft failure following kidney-pancreas transplantation. Thromboelastography (TEG)-directed anticoagulation protocol has shown that approximately one-third of the patients undergoing pancreas transplantation require therapeutic anticoagulation to prevent the occurrence of graft thrombosis. This article presents the argument for individualised anticoagulation in these patients based on their TEG tracings and suggests the use of TEG in patients undergoing pancreas transplantation.
authors.affiliation: Oxford Transplant Centre, Churchill Hospital, Headington, Oxford, UK. acvaidya@yahoo.com
authors.forename: Anil
authors.initials: A
authors.lastname: Vaidya
authors.forename: A S
authors.initials: AS
authors.lastname: Muthusamy
authors.forename: V G
authors.initials: VG
authors.lastname: Hadjianastassiou
authors.forename: D
authors.initials: D
authors.lastname: Roy
authors.forename: D E
authors.initials: DE
authors.lastname: Elker
authors.forename: P
authors.initials: P
authors.lastname: Moustafellos
authors.forename: A
authors.initials: A
authors.lastname: Muktadir
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: P J
authors.initials: PJ
authors.lastname: Friend
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D005260:Female; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D016035:Pancreas Transplantation; D011182:Postoperative Care; D012189:Retrospective Studies; D017131:Thrombectomy; D013916:Thrombelastography; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D000925:Anticoagulants