[Clinicopathologic and immunohistochemical study of primary non-Hodgkin lymphoma of the female genital system].
OBJECTIVE
To investigate the clinicopathology and immunophenotype of primary non-Hodgkin lymphoma (NHL) of the female genital system, and to analyze the prognosis of such tumors.


METHODS
Clinicopathologic features of 43 cases of primary NHL of the female genital system were studied retrospectively, with the histological classification based on the Classification of Haematopoietic and Lymphoid Tumors (WHO, 2001). Immunochemistry technique, in-situ-hybridization and polymerase chain reaction methods were used to detect the immunophenotype, epstein barrvirus (EB) virus infection status and immunoglobulin heavy chain gene rearrangement, respectively.


RESULTS
(1) Primary lesions: there were 24 cases of lymphoma originating in the ovary, 3 cases in the endometrium, 10 cases in the cervix, 2 cases in the vagina and 4 cases in the vulva. (2) Staging: 12 cases (28%) were in stage I, 9 cases (21%) in stage II, and 22 cases (51%) in stage III. (3) Histological classification: 37 cases (86%) were diffuse large B cell lymphoma (DLBCL), 3 cases were Burkitt lymphoma and the remaining 3 cases were unspecified peripheral T-cell lymphoma according to biopsy, immunophenotype analysis, in-situ-hybridization technique and IgH gene rearrangement detection. (4) Prognosis analysis: increase in the level of lactic acid dehydrogenase, stage III, DLBCL and single operation suggest poor prognosis.


CONCLUSIONS
Establishment of the diagnosis of primary NHL of the female genital system is based on biopsy, immunophenotype analysis, in-situ-hybridization technique and IgH gene rearrangement detection, which play important roles in diagnosis and differential diagnosis of the tumor. Combined therapy is the first choice of therapeutic regimens.
Jiang
Xue-feng
XF
Department of Gynaecology and Obstetrics, West China Second Hospital of Sichuan University, Chengdu 610041, China.
Yang
Kai-xuan
KX
Peng
Zhi-lan
ZL
Xu
Lian
L
Huang
Qin
Q
Li
Qian
Q
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D007770:L-Lactate Dehydrogenase; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology / Q000628:therapy; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000473:pathology / Q000628:therapy
D015415:Biomarkers; D007770:L-Lactate Dehydrogenase