title: Anti-leishmanial and immunomodulatory activities of extracts from Portulaca hirsutissima and Portulaca werdermannii.
abstract: Ethyl acetate and chloroform extracts from aerial parts of Portulaca werdermannii and P. hirsutissima were tested in lymphoproliferation assays and axenic cultures of Leishmania amazonensis and Trypanosoma cruzi. Both extracts of P. werdermannii and P. hirsutissima had a potent inhibitory activity on lymphocyte proliferation. On the contrary, only the chloroformic extract of both plants inhibited L. amazonensis growth, without effect on T. cruzi cultures. These results indicate these Portulaca species as potential sources of new active molecules for the treatment of leishmaniasis and immune-mediated pathologies.
authors.affiliation: Laboratório de Engenharia Tecidual e Imunofarmacologia, Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz, Salvador, Bahia, Brazil. jfernando@cpqgm.fiocruz.br
authors.forename: José Fernando Oliveira
authors.initials: JF
authors.lastname: Costa
authors.forename: Alice Costa
authors.initials: AC
authors.lastname: Kiperstok
authors.forename: Juceni Pereira de Lima
authors.initials: JP
authors.lastname: David
authors.forename: Jorge Maurício
authors.initials: JM
authors.lastname: David
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Giulietti
authors.forename: Luciano Paganucci
authors.initials: LP
authors.lastname: de Queiroz
authors.forename: Ricardo Ribeiro
authors.initials: RR
authors.lastname: dos Santos
authors.forename: Milena Botelho Pereira
authors.initials: MB
authors.lastname: Soares
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D049109:Cell Proliferation; D005260:Female; D007155:Immunologic Factors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects; D007898:Leishmaniasis, Visceral / Q000188:drug therapy; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031822:Portulaca; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D007155:Immunologic Factors; D010936:Plant Extracts