[Features of the metabolism of various drugs involving cytochrome P-450 isoenzymes].
Substrates of cytochrome P450 isoenzymes have been analyzed and systematized, and a database is created in which the substrates are classified in accordance with the chemical structure of drugs. Each substrate is characterized by the oxidation reaction and the resulting metabolites, with allowance for the Michaelis - Menten pharmacokinetic parameters. Each isoenzyme metabolises certain preferred substrates, depending on the presence of active structural groups or moieties susceptible to oxidation and on the stereoselectivity of drugs. The reaction direction also depends on the specific interactions between the active groups of a substrate and the given isoenzyme.
Filimonova
A A
AA
Ziganshin
A U
AU
Ziganshina
L E
LE
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D013379:Substrate Specificity
D007527:Isoenzymes; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System