Carbohydrate metabolism changes in cystic fibrosis.
OBJECTIVE
To assess the prevalence of impaired glucose tolerance (ITG) and diabetes mellitus (DMRCF) in a group of patients with cystic fibrosis (CF). To study clinical status-related variables and to compare age with the evolution of their carbohydrate metabolism (CHM).


METHODS
Thirty patients with CF (1.5-26 years). Oral glucose tolerance test (OGTT) in 28 patients.


RESULTS
Three patients (10%) showed ITG and four DMRCF (13.3%). CF patients with impaired CHM (ICHM) were older (p = 0.006), and had longer times since diagnosis and first sputum colonization (p = 0.001, p < 0.001). Homozygous deltaF508 mutation was significant (p = 0.001). Insulin peak, area under the curve for insulin, insulin resistance, insulin sensitivity, and pancreatic beta-cell function were all significant.


CONCLUSIONS
ICHM was present in 23.3%. Age, time since diagnosis of CF, first sputum colonization and homozygous deltaF508 mutation were significantly associated. CHM in patients with CF is similar to that in the population without CF in the early years.
Domínguez-García
Angela
A
Paediatric Endocrinology Unit, Paediatrics Service, Hospital Universitario Materno Infantil de Canarias, Las Palmas, Spain. argdom@wanadoo.es
Quinteíro-González
Sofía
S
Peña-Quintana
Luis
L
Ramos-Macias
Leticia
L
Quintana-Martel
Mercedes
M
Saavedra-Santana
Pedro
P
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D050260:Carbohydrate Metabolism; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000150:complications* / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology* / Q000209:etiology* / Q000235:genetics; D005951:Glucose Tolerance Test; D006801:Humans; D007223:Infant; D007333:Insulin Resistance; D008297:Male; D009154:Mutation
C505032:CFTR protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator