title: Modulating the activity of neural crest regulatory factors.
abstract: Substantial progress has been made in defining the regulatory factors involved in generating multipotent neural crest cells at the neural plate border of vertebrate embryos, controlling the onset of their migratory behavior, and directing their differentiation into one of a diverse array of derivatives. Growing evidence suggests that these factors function as a complex network, in some cases displaying overlapping functions and cross-regulatory interactions. Mechanisms are emerging for how some of these regulatory components are controlled post-translationally and the extent to which their activities are conserved across species.
authors.affiliation: Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Taylor
authors.forename: Carole
authors.initials: C
authors.lastname: LaBonne
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics* / Q000502:physiology; D002465:Cell Movement / Q000235:genetics* / Q000502:physiology; D004475:Ectoderm / Q000166:cytology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D008954:Models, Biological; D009432:Neural Crest / Q000166:cytology / Q000378:metabolism*; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
chemical_list: D000071250:Snail Family Transcription Factors; D014157:Transcription Factors