Photocleavable molecule for laser desorption ionization mass spectrometry.
A new photocleavable molecule for laser desorption ionization mass spectrometry (LDI-MS) was designed and synthesized. The molecule exhibited high sensitivity for negative mode MS detection with good chemical stability. The molecule was successfully applied to molecular tag for (LDI-MS). Kinetic measurement of the amidation reaction and monitoring of aminolysis of acetylated sugars were demonstrated with the molecular tag.
Maki
Toshihide
T
Joint Research Center, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. maki@nagasaki-u.ac.jp
Ishida
Koji
K
D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010777:Photochemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*