Inhibition of tubule-cell proliferation to prevent cyst formation: a new avenue to treat ADPKD?
Tubule-cell hyperproliferation precedes cyst development in autosomal dominant polycystic kidney disease (ADPKD). Parker et al. report that insulin-like growth factor-1 stimulates ADPKD cell proliferation by activating Ras and Raf; inhibition of Ras or Raf abolished this effect. Inhibiting tubule-cell proliferation could halt cyst formation and prolong survival of functional tubules, offering a new treatment for ADPKD patients.
Bello-Reuss
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Texas Tech University Health Science Center, Internal Medicine, Division of Nephrology and Hypertension, Lubbock, Texas 79430, USA. elsa.bello-reuss@ttuhsc.edu
D049109:Cell Proliferation / Q000187:drug effects*; D003560:Cysts / Q000517:prevention & control; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D007684:Kidney Tubules / Q000473:pathology*; D016891:Polycystic Kidney, Autosomal Dominant / Q000188:drug therapy* / Q000473:pathology; D015398:Signal Transduction; D048490:raf Kinases / Q000187:drug effects / Q000378:metabolism; D020703:ras GTPase-Activating Proteins / Q000187:drug effects / Q000378:metabolism
D020703:ras GTPase-Activating Proteins; D007334:Insulin-Like Growth Factor I; D048490:raf Kinases