title: Whole-body iodine-131 metaiodobenzylguanidine imaging for detection of bone metastases in patients with paraganglioma: comparison with bone scintigraphy.
abstract: Iodine-131 metaiodobenzylguanidine ((131)I-MIBG) therapy is an effective treatment for patients with malignant paraganglioma for which surgical resection is not indicated. We performed high-dose (131)I-MIBG therapy on two patients with malignant paraganglioma and multiple bone metastases. The bone metastases were diagnosed by magnetic resonance imaging (MRI). Metastatic bone lesions were evaluated by whole-body (131)I-MIBG imaging and bone scintigraphy. Whole-body (131)I-MIBG imaging showed extensive metastatic bone lesions, whereas conventional bone scintigraphy did not. There was a remarkable discrepancy between (131)I-MIBG imaging and bone scintigraphy in the diagnosis of metastatic bone lesions of malignant paraganglioma in our two patients. High-dose (131)I-MIBG imaging may detect early stages of bone metastases, compared with bone scintigraphy, in patients with malignant paraganglioma.
authors.affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Sapporo, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Inoue
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: Koichi
authors.initials: K
authors.lastname: Morita
authors.forename: Tohru
authors.initials: T
authors.lastname: Shiga
authors.forename: Kakuko
authors.initials: K
authors.lastname: Kanegae
authors.forename: Kenji
authors.initials: K
authors.lastname: Hirata
authors.forename: Shozo
authors.initials: S
authors.lastname: Okamoto
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D019797:3-Iodobenzylguanidine / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary*; D001842:Bone and Bones / Q000473:pathology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D009362:Neoplasm Metastasis; D018358:Neuroendocrine Tumors / Q000473:pathology* / Q000532:radiotherapy; D010235:Paraganglioma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000532:radiotherapy; D011877:Radionuclide Imaging / Q000379:methods; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D051598:Whole Body Imaging
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine