[Research progression of deacetylase (SIRT1)].
The silent information regulator protein 2 (Sir2) and its homologues play an important role in the regulation of cellular physiological processes such as survival, apoptosis, and aging. SIRT1, the mammalian Sir 2 homologue, has been shown to deacetylate a wide range of non-histone substrates and histone substrates. It has been constantly reported that SIRT1 may be associated with the occurrence of metabolic syndrome, genomic homeostasis, tumors, and neurodegenerative diseases. Calorie restriction may mitigate many major diseases in rodent models by SIRT1-mediated deacetylase activity and prolong the life expectancies in these animals. Therefore, SIRT1 may be emphasized as a new therapy target for many different diseases.
Chen
Hou-zao
HZ
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.
Zhang
Zhu-qin
ZQ
Wei
Yu-sheng
YS
Liu
De-pei
DP
D000818:Animals; D031204:Caloric Restriction; D006801:Humans; D008136:Longevity; D056564:Sirtuin 1 / Q000235:genetics / Q000502:physiology*; D013379:Substrate Specificity
D056564:Sirtuin 1