Novel antioxidants in anthracycline cardiotoxicity.
It has been suggested nitroxides and their amine precursors prevent incidence of damage caused by superoxide and hydroxyl radicals formed during the oxidative metabolism of doxorubicin (DOX) and daunorubicin (DAU). Both doxorubicin and daunorubicin have been associated with cardiac toxicity in both adults and children. The authors herein suggest that cardioprotective molecules modified by nitroxides and their secondary amine precursors can prevent or diminish the anthracycline-induced cardiomyopathy by accumulating in cardiomiocytes.
Hideg
Kálmán
K
Department of Organic and Medicinal Chemistry, University of Pécs, P.O. Box 99, 7602 Pecs, Hungary. kalman.hideg@aok.pte.hu
Kálai
Tamás
T
D000588:Amines / Q000378:metabolism; D000818:Animals; D018943:Anthracyclines / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D003497:Cyclic N-Oxides / Q000494:pharmacology / Q000627:therapeutic use; D006331:Heart Diseases / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D009589:Nitrogen Oxides / Q000378:metabolism; D013113:Spin Labels
D000588:Amines; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D003497:Cyclic N-Oxides; D009589:Nitrogen Oxides; D013113:Spin Labels; C001803:tempol