title: In vitro molecular mechanisms of bisphenol A action.
abstract: Bisphenol A (BPA, 2,2-bis (4-hydroxyphenyl) propane; CAS# 80-05-7) is a chemical used primarily in the manufacture of polycarbonate plastic, epoxy resins and as a non-polymer additive to other plastics. Recent evidence has demonstrated that human and wildlife populations are exposed to levels of BPA which cause adverse reproductive and developmental effects in a number of different wildlife species and laboratory animal models. However, there are major uncertainties surrounding the spectrum of BPA's mechanisms of action, the tissue-specific impacts of exposures, and the critical windows of susceptibility during which target tissues are sensitive to BPA exposures. As a foundation to address some of those uncertainties, this review was prepared by the "In vitro" expert sub-panel assembled during the "Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assessing Risks to Human Health" workshop held in Chapel Hill, NC, Nov 28-29, 2006. The specific charge of this expert panel was to review and assess the strength of the published literature pertaining to the mechanisms of BPA action. The resulting document is a detailed review of published studies that have focused on the mechanistic basis of BPA action in diverse experimental models and an assessment of the strength of the evidence regarding the published BPA research.
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Yelena B
authors.initials: YB
authors.lastname: Wetherill
authors.forename: Benson T
authors.initials: BT
authors.lastname: Akingbemi
authors.forename: Jun
authors.initials: J
authors.lastname: Kanno
authors.forename: John A
authors.initials: JA
authors.lastname: McLachlan
authors.forename: Angel
authors.initials: A
authors.lastname: Nadal
authors.forename: Carlos
authors.initials: C
authors.lastname: Sonnenschein
authors.forename: Cheryl S
authors.initials: CS
authors.lastname: Watson
authors.forename: R Thomas
authors.initials: RT
authors.lastname: Zoeller
authors.forename: Scott M
authors.initials: SM
authors.lastname: Belcher
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D004305:Dose-Response Relationship, Drug; D052244:Endocrine Disruptors / Q000493:pharmacokinetics / Q000633:toxicity; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D005298:Fertility / Q000187:drug effects; D006801:Humans; D008297:Male; D010636:Phenols / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds