Synthesis of a new artificial host for the binding of dipeptides in water.
An artificial peptide receptor was prepared by a simple procedure. Initial binding studies (UV titrations) in buffered water showed preferential complexation of N-acetyl-dipeptide carboxylates containing alanine in the C-terminal position in comparison with simple amino acids, other dipeptides and two tripeptides.
Schmuck
Carsten
C
Institut für Organische Chemie, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany. schmuck@chemie.uni-wuerzburg.de
Hernandez-Folgado
Laura
L
D002264:Carboxylic Acids / Q000737:chemistry; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D014867:Water / Q000737:chemistry*
D002264:Carboxylic Acids; D004151:Dipeptides; D014867:Water