title: Distribution of laminin, vimentin and desmin in the rat uterus during initial stages of implantation.
abstract: The aim of this study was to investigate the immunohistochemical distribution of laminin, vimentin and desmin during the implantation period in the rat since ECM remodelling and the expression of intermediate filaments (Ifs) is essential for successful decidualization and implantation. On day 4 of pregnancy, laminin was found in a few endometrial stromal cells (ESC), the basement membrane of the numerous endometrial blood vessels, in endometrial glands and as well as in the uterine epithelium. The localization of vimentin on day 4 of pregnancy was widespread in the ESC. However, desmin immunoreactivity was low in ESC on this day of pregnancy. On day 6 of pregnancy, laminin and vimentin were localized in the decidual area underlying luminal epithelium and around the implanting embryo. Additionally, desmin was found to be present densely in decidual cells of the anti-mesometrial region where implantation takes place. Finally, on day 8 of pregnancy, laminin was present in decidual and parietal endodermal cells, whereas vimentin was immunolocalized in primary and secondary decidual regions in the endometrium. In contrast, desmin was detected in some parts of the secondary decidual zone. In conclusion, these proteins could have crucial roles in decidualization and implantation.
authors.affiliation: Department of Histology and Embryology, Akdeniz University Medical Faculty, Campus, Antalya 07070, Turkey. korgun@akdeniz.edu.tr
authors.forename: E T
authors.initials: ET
authors.lastname: Korgun
authors.forename: S
authors.initials: S
authors.lastname: Cayli
authors.forename: M
authors.initials: M
authors.lastname: Asar
authors.forename: R
authors.initials: R
authors.lastname: Demir
mesh_terms: D000818:Animals; D003893:Desmin / Q000378:metabolism*; D010064:Embryo Implantation; D005260:Female; D007797:Laminin / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D051381:Rats; D014599:Uterus / Q000166:cytology / Q000378:metabolism*; D014746:Vimentin / Q000378:metabolism*
chemical_list: D003893:Desmin; D007797:Laminin; D014746:Vimentin