title: Physical inactivity in adult survivors of childhood acute lymphoblastic leukemia: a report from the childhood cancer survivor study.
abstract: OBJECTIVE
  To determine if adult survivors of childhood acute lymphoblastic leukemia (ALL) are less active (and more inactive) than the general population and to identify modifying factors.
  
  
  METHODS
  Physical activity was assessed by self-report in 2,648 adult survivors of the Childhood Cancer Survivor Study. Participants in the Behavioral Risk Factor Surveillance System (BRFSS) survey administered through the Centers for Disease Control and Prevention (CDC) were used as a comparison group.
  
  
  RESULTS
  Survivors had a mean age of 28.7 years (range, 18.0-44.0 years) and were a mean of 23.1 years from their cancer diagnosis (range, 16.0-33.8 years). In multivariate models, ALL survivors were more likely to not meet CDC recommendations for physical activity [odds ratio (OR), 1.44; 95% confidence interval (95% CI), 1.32-1.57] and more likely to be inactive (OR, 1.74; 95% CI, 1.56-1.94) in comparison with the BRFSS general population. Survivors treated with >20-Gy cranial radiotherapy were at particular risk. Compared with BRFSS participants and adjusted for age, race, and ethnicity, survivors were more likely to not meet CDC recommendations (females: OR, 2.07, 95% CI, 1.67-2.56; males: OR, 1.43, 95% CI, 1.16-1.76) and more likely to be inactive (females: OR, 1.86; 95% CI, 1.50-2.31; males: OR, 1.84; 95% CI, 1.45-2.32).
  
  
  CONCLUSIONS
  Long-term survivors of childhood ALL are less likely to meet physical activity recommendations and more likely to report no leisure-time physical activity in the past month. This level of inactivity likely further increases their risk of cardiovascular disease, osteoporosis, and all-cause mortality.
authors.affiliation: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Florin
authors.forename: G Edgar
authors.initials: GE
authors.lastname: Fryer
authors.forename: Thomas
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Michael
authors.initials: M
authors.lastname: Weitzman
authors.forename: Ann C
authors.initials: AC
authors.lastname: Mertens
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Hudson
authors.forename: Charles A
authors.initials: CA
authors.lastname: Sklar
authors.forename: Karen
authors.initials: K
authors.lastname: Emmons
authors.forename: Andrea
authors.initials: A
authors.lastname: Hinkle
authors.forename: John
authors.initials: J
authors.lastname: Whitton
authors.forename: Marilyn
authors.initials: M
authors.lastname: Stovall
authors.forename: Leslie L
authors.initials: LL
authors.lastname: Robison
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Oeffinger
mesh_terms: D000293:Adolescent; D000328:Adult; D001294:Attitude to Health; D015992:Body Mass Index; D015331:Cohort Studies; D015444:Exercise; D005260:Female; D006801:Humans; D007899:Leisure Activities; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D017741:Survivors; D013997:Time Factors; D014481:United States / Q000453:epidemiology