[Exhaled breath condensate in the assessment of airway inflammation].
Exhaled breath condensate (EBC) is a novel, non-invasive method for obtaining samples from the lung. Use of exhaled condensate as a source of biomarkers is based on the hypothesis that aerosol particles of exhaled breath reflect the composition of airway lining fluid. The technique is simple to perform, effort-independent, rapid, may be repeated frequently, and can be easily perform even in young children, adults, or patients with severe disease. EBC contains large number of various mediators including isoprostanes, cysteinyl-leukotrienes, adenosine, hydrogen peroxide, peptides, cytokines. Concentrations of these biomarkers are influenced by inflammation, oxidative stress and modulated by therapeutic interventions. EBC can be used to assess airway inflammation and oxidative stress in the respiratory tract, in differential diagnosis of airway disease and in the treatment monitoring.
Skiepko
Roman
R
Klinika Alergologii i Chorób Wewnetrznych, Akademii Medycznej w Białymstoku.
Zietkowski
Ziemowit
Z
Tomasiak
Maria Magdalena
MM
Bodzenta-Lukaszyk
Anna
A
D000328:Adult; D000641:Ammonia / Q000032:analysis; D001249:Asthma / Q000175:diagnosis / Q000209:etiology; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests / Q000379:methods*; D001991:Bronchitis / Q000150:complications / Q000175:diagnosis*; D002248:Carbon Monoxide / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D045853:Exhalation; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis; D018836:Inflammation Mediators; D028421:Isoprostanes / Q000032:analysis; D007975:Leukotriene B4 / Q000032:analysis; D009569:Nitric Oxide / Q000032:analysis* / Q000378:metabolism; D018384:Oxidative Stress; D012137:Respiratory System / Q000503:physiopathology
D015415:Biomarkers; D018836:Inflammation Mediators; D028421:Isoprostanes; D007975:Leukotriene B4; D009569:Nitric Oxide; D000641:Ammonia; D002248:Carbon Monoxide; D006861:Hydrogen Peroxide