title: Anti-anaphylactic effect of Euphorbia hirta.
abstract: The Euphorbia hirta ethanolic extract (EH A001) was found to possess a prominent anti-anaphylactic activity. A preventive effect of EH-A001 given by oral route at dose from 100 to 1000 mg/kg was observed against compound 48/80-induced systemic anaphylaxis. At the same range of dose, EH-A001 inhibited passive cutaneous anaphylaxis (PCA) in rat and active paw anaphylaxis in mice. A suppressive effect of EH-A001 was observed on the release of TNF-alpha and IL-6 from anti-DNP-HSA activated rat peritoneal mast cells.
authors.affiliation: Division of Pharmacology and Natural Product Chemistry, Indian Institute of Integrative Medicine, Jammu-Tawi, India. msyousf@rediffmail.com
authors.forename: M S
authors.initials: MS
authors.lastname: Youssouf
authors.forename: P
authors.initials: P
authors.lastname: Kaiser
authors.forename: M
authors.initials: M
authors.lastname: Tahir
authors.forename: G D
authors.initials: GD
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: V K
authors.initials: VK
authors.lastname: Sharma
authors.forename: N K
authors.initials: NK
authors.lastname: Satti
authors.forename: S E
authors.initials: SE
authors.lastname: Haque
authors.forename: R K
authors.initials: RK
authors.lastname: Johri
mesh_terms: D000284:Administration, Oral; D000707:Anaphylaxis / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D028481:Euphorbia; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D015850:Interleukin-6 / Q000096:biosynthesis; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis; D010537:Peritoneum / Q000166:cytology; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D003189:p-Methoxy-N-methylphenethylamine
chemical_list: D006634:Histamine H1 Antagonists; D015850:Interleukin-6; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D003189:p-Methoxy-N-methylphenethylamine