title: Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease.
abstract: An association of the H1 haplotype and subhaplotypes in the microtubule-associated protein Tau (MAPT) gene with Parkinson's disease (PD) has been reported. To further evaluate their role in PD, we genotyped a sample set of 765 cases and controls consisting of two large European subgroups of German (n=418) and Serbian (n=347) origin for the MAPT haplotypes H1 and H2. The H1/H1 carriers were tested for three additional MAPT polymorphisms. In the Serbian sample, there was significant evidence (P=0.0108) of an association of the H1/H1 genotype and PD. Surprisingly, in the German sample, we did not find significant differences in genotype or haplotype frequencies between patients and controls. These results suggest that the role of H1 haplotypes in the etiology of PD may be ethnically dependent.
authors.affiliation: Department of Neurology, University of Lübeck, Lübeck, Germany.
authors.forename: Susan
authors.initials: S
authors.lastname: Winkler
authors.forename: Inke R
authors.initials: IR
authors.lastname: König
authors.forename: Katja
authors.initials: K
authors.lastname: Lohmann-Hedrich
authors.forename: Peter
authors.initials: P
authors.lastname: Vieregge
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kostic
authors.forename: Christine
authors.initials: C
authors.lastname: Klein
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D005858:Germany / Q000453:epidemiology / Q000208:ethnology; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015022:Yugoslavia / Q000453:epidemiology / Q000208:ethnology; D016875:tau Proteins / Q000235:genetics*
chemical_list: C054369:MAPT protein, human; D016875:tau Proteins