[GABA(B) receptors and amnesia in mice withalternative stereotypes of behavior].
The influence of agonists and antagonists of GABA(B) receptors on the development of amnesia has been studied using the passive avoidance test in C57Bl/6J mice with previously generated aggressive and submissive behavioral stereotypes. It is established that baclofen in a dose of 1 mg/kg produces amnesia in aggressive mice and imparts stability with respect to the amnestic influence in submissive mice. Phaclofen in a dose of 5 mg/kg prevents the development of amnesia that is most strongly pronounced in submissive mice.
Dubrovina
N I
NI
Loskutova
L V
LV
D000374:Aggression / Q000502:physiology; D000647:Amnesia / Q000139:chemically induced* / Q000517:prevention & control; D000818:Animals; D001418:Baclofen / Q000031:analogs & derivatives* / Q000494:pharmacology*; D018755:GABA Agonists / Q000494:pharmacology*; D018756:GABA Antagonists / Q000494:pharmacology*; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D008297:Male; D051379:Mice; D018080:Receptors, GABA-B / Q000187:drug effects*; D013239:Stereotyped Behavior
D018755:GABA Agonists; D018756:GABA Antagonists; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D018080:Receptors, GABA-B; C052329:phaclofen; D001418:Baclofen