title: Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden.
abstract: BACKGROUND
  The incidence and severity of invasive group A streptococcal infection demonstrate great variability over time, which at least, in part, seems to be related to group A streptococcal type distribution among the human population.
  
  
  METHODS
  An enhanced surveillance study of invasive group A streptococcal infection (746 isolates) was performed in Sweden from April 2002 through December 2004. Noninvasive isolates from either the throat or skin (773 isolates) were collected in parallel for comparison. Clinical and epidemiological data were obtained from 88% of patients with invasive disease and were related to isolate characteristics, including T type, emm sequence type, and the presence of 9 superantigen genes, as well as pulsed-field gel electrophoresis pattern comparisons of selected isolates.
  
  
  RESULTS
  The annual incidence was 3.0 cases per 100,000 population. Among the patients with invasive disease, 11% developed streptococcal toxic shock syndrome, and 9.5% developed necrotizing fasciitis. The overall case-fatality rate was 14.5%, and 39% of the patients with streptococcal toxic shock syndrome died (P<.001). The T3/13/B3264 cluster accounted for 33% of invasive and 25% of noninvasive isolates. Among this most prevalent type cluster, emm types 89 and 81 dominated. Combined results from pulsed-field gel electrophoresis, emm typing, and superantigen gene profiling identified subgroups within specific emm types that are significantly more prone to cause invasive disease than were other isolates of the same type.
  
  
  CONCLUSIONS
  This study revealed a changing epidemiology of invasive group A streptococcal infection in Sweden, with emergence of new emm types that were previously not described. The results also suggest that some clones may be particularly prone to cause invasive disease.
authors.affiliation: Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna, Sweden. Jessica.Darenberg@smi.ki.se
authors.forename: Jessica
authors.initials: J
authors.lastname: Darenberg
authors.forename: Bogdan
authors.initials: B
authors.lastname: Luca-Harari
authors.forename: Aftab
authors.initials: A
authors.lastname: Jasir
authors.forename: Andreas
authors.initials: A
authors.lastname: Sandgren
authors.forename: Helena
authors.initials: H
authors.lastname: Pettersson
authors.forename: Claes
authors.initials: C
authors.lastname: Schalén
authors.forename: Mari
authors.initials: M
authors.lastname: Norgren
authors.forename: Victoria
authors.initials: V
authors.lastname: Romanus
authors.forename: Anna
authors.initials: A
authors.lastname: Norrby-Teglund
authors.forename: Birgitta Henriques
authors.initials: BH
authors.lastname: Normark
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015373:Bacterial Typing Techniques; D002648:Child; D002675:Child, Preschool; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D015995:Prevalence; D012737:Sex Factors; D013290:Streptococcal Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors
chemical_list: D005819:Genetic Markers