title: Natural rubber latex sensitisation and allergy in patients with spina bifida, urogenital disorders and oesophageal atresia compared with a normal paediatric population.
abstract: BACKGROUND
  Natural rubber latex (NRL) contains proteins which, after repeated contact with latex products and an allergic predisposition (atopy), can lead to sensitisation (specific IgE against NRL proteins) or allergy (type 1 allergy with symptoms from urticaria to allergic shock). Spina bifida patients are known to be a high risk group for latex allergy and sensitisation due to numerous operations beginning soon after birth. In the study presented here we compared spina bifida patients with patients who also underwent repeated operations beginning soon after birth (urological malformations) or underwent surgery once in the neonatal period but had numerous anaesthesias because of repeated treatment with a bougie (oesophageal atresia). In this setting the influence of surgery and anaesthesia on NRL-sensitisation was investigated.
  
  
  METHODS
  We investigated the prevalence of NRL-specific IgE (> 0.35 kU/l, ImmunoCAP system, Pharmacia) in a normal paediatric population (neither atopic nor having undergone surgery) (group I), spina bifida patients (group II), children with urogenital malformations (group III) and children with oesophago-tracheal malformations (group IV).
  
  
  RESULTS
  The highest rate of NRL-sensitised patients was found in the spina bifida group (II) (48 %), followed by groups III and IV with 17 % each, compared to 4 % for the control group. NRL-allergic reactions were noted only in the patients with spina bifida and the urological malformation group (18 % in group II, 8 % in Group III). Apart from atopy the number of operations could be identified as a risk factor for the development of NRL-sensitisation and allergy (group II, III). The prevalence of latex allergy was lower after repeated anaesthesia (group IV) than after repeated surgery.
  
  
  CONCLUSIONS
  In addition to the known high risk group of spina bifida patients, other patients with congenital malformations and early surgery also have a significant risk for latex sensitisation. When treating patients with malformations requiring repeated surgery, prophylactic measures similar to those for spina bifida patients should be considered.
authors.affiliation: Children's Hospital, Kliniken der Stadt Köln gGmbH, Cologne, Germany. CremerR@kliniken-koeln.de
authors.forename: R
authors.initials: R
authors.lastname: Cremer
authors.forename: M
authors.initials: M
authors.lastname: Lorbacher
authors.forename: F
authors.initials: F
authors.lastname: Hering
authors.forename: R
authors.initials: R
authors.lastname: Engelskirchen
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004933:Esophageal Atresia / Q000601:surgery*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D020315:Latex Hypersensitivity / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D011159:Population Surveillance; D012307:Risk Factors; D016135:Spinal Dysraphism / Q000601:surgery*; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D014564:Urogenital Abnormalities / Q000601:surgery*