[ABC A-subclass transporters--key regulators of molecular lipid transport].
The controlled uptake and release of lipid compounds is a hallmark feature of living cells. Numerous factors have been implicated in these complex transmembrane transport processes. The recent discovery of a novel class of transporter molecules, the group of A-subclass ATP-binding cassette (ABC) transporters, has brought new insights into the molecular basis of cellular lipid transport. Available evidence indicates that individual ABC A-subclass transporters function as key components of highly specialized cellular lipid export machineries in major physiological systems and, when defective, cause hereditary diseases in the cardiovascular, respiratory, visual and integumentary systems, respectively. Intriguingly, a steadily growing body of evidence suggests that ABC A lipid transporters play important roles in the pathogenesis of complex disorders with high incidence including atherosclerosis, Alzheimer's disease and age-related macula degeneration. The present article reviews the biology of this emerging group of proteins and their implication in human pathologies.
Wenzel
Jürgen J
JJ
Institut für Klinische Chemie und Laboratoriumsmedizin, Johannes Gutenberg-Universität, Mainz.
Piehler
Armin
A
Kaminski
Wolfgang E
WE
D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000544:Alzheimer Disease / Q000097:blood / Q000235:genetics; D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000235:genetics; D001921:Brain / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D015870:Gene Expression / Q000502:physiology; D017490:Ichthyosis, Lamellar / Q000235:genetics; D008055:Lipids / Q000097:blood*; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000235:genetics; D051379:Mice; D012162:Retinal Degeneration / Q000235:genetics
C473801:ABCA12 protein, human; C441524:ABCA3 protein, human; C056475:ABCA4 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D008076:Cholesterol, HDL; D008055:Lipids