Automated liquid-liquid extraction workstation for library synthesis and its use in the parallel and chromatography-free synthesis of 2-alkyl-3-alkyl-4-(3H)-quinazolinones.
An automated liquid-liquid extraction workstation has been developed. This module processes up to 96 samples in an automated and parallel mode avoiding the time-consuming and intensive sample manipulation during the workup process. To validate the workstation, a highly automated and chromatography-free synthesis of differentially substituted quinazolin-4(3H)-ones with two diversity points has been carried out using isatoic anhydride as starting material.
Carpintero
Mercedes
M
Centro de Investigación Lilly, S. A, Avenida de la Industria 30, 28108-Alcobendas, Madrid, Spain.
Cifuentes
Marta
M
Ferritto
Rafael
R
Haro
Rubén
R
Toledo
Miguel A
MA
D001331:Automation; D002853:Chromatography, Liquid / Q000295:instrumentation*; D009682:Magnetic Resonance Spectroscopy; D052999:Quinazolinones / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization
D052999:Quinazolinones