title: Newborn size, infant and childhood growth, and body composition and cardiovascular disease risk factors at the age of 6 years: the Pune Maternal Nutrition Study.
abstract: OBJECTIVE
  To study associations of size and body proportions at birth, and growth during infancy and childhood, to body composition and cardiovascular disease (CVD) risk factors at the age of 6 years.
  
  
  METHODS
  The Pune Maternal Nutrition Study, a prospective population-based study of maternal nutrition and CVD risk in rural Indian children.
  
  
  METHODS
  Body composition and CVD risk factors measured in 698 children at 6 years were related to body proportions and growth from birth.
  
  
  METHODS
  Anthropometry was performed every 6 months from birth. At 6 years, fat and lean mass (dual X-ray absorptiometry) and CVD risk factors (insulin resistance, blood pressure, glucose tolerance, plasma lipids) were measured.
  
  
  RESULTS
  Compared with international references (NCHS, WHO) the children were short, light and thin (mean weight <-1.0 s.d. at all ages). Larger size and faster growth in all body measurements from birth to 6 years predicted higher lean and fat mass at 6 years. Weight and height predicted lean mass more strongly than fat mass, mid-upper arm circumference (MUAC) predicted them both approximately equally and skinfolds predicted only fat mass. Neither birthweight nor the 'thin-fat' newborn phenotype, was related to CVD risk factors. Smaller MUAC at 6 months predicted higher insulin resistance (P<0.001) but larger MUAC at 1 year predicted higher systolic blood pressure (P<0.001). After infancy, higher weight, height, MUAC and skinfolds, and faster growth of all these parameters were associated with increased CVD risk factors.
  
  
  CONCLUSIONS
  Slower muscle growth in infancy may increase insulin resistance but reduce blood pressure. After infancy larger size and faster growth of all body measurements are associated with a more adverse childhood CVD risk factor profile. These rural Indian children are growing below international 'norms' for body size and studies are required in other populations to determine the generalizability of the findings.
authors.affiliation: Diabetes Unit, King Edward Memorial Hospital, Rasta Peth, Pune 411011, India. joglekar@pn2.vsnl.net.in
authors.forename: C V
authors.initials: CV
authors.lastname: Joglekar
authors.forename: C H D
authors.initials: CH
authors.lastname: Fall
authors.forename: V U
authors.initials: VU
authors.lastname: Deshpande
authors.forename: N
authors.initials: N
authors.lastname: Joshi
authors.forename: A
authors.initials: A
authors.lastname: Bhalerao
authors.forename: V
authors.initials: V
authors.lastname: Solat
authors.forename: T M
authors.initials: TM
authors.lastname: Deokar
authors.forename: S D
authors.initials: SD
authors.lastname: Chougule
authors.forename: S D
authors.initials: SD
authors.lastname: Leary
authors.forename: C
authors.initials: C
authors.lastname: Osmond
authors.forename: C S
authors.initials: CS
authors.lastname: Yajnik
mesh_terms: D000886:Anthropometry; D001724:Birth Weight / Q000502:physiology*; D001823:Body Composition / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007194:India; D007223:Infant; D007231:Infant, Newborn; D009035:Mothers; D009752:Nutritional Status / Q000502:physiology*; D011446:Prospective Studies; D012307:Risk Factors; D012423:Rural Health