Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol.
Nitric oxide (NO) is an efficient antimicrobial agent. A role for mycothiol in protecting mycobacteria from nitrosative damage was revealed by showing that a Mycobacterium smegmatis mutant is sensitive to NO. A direct correlation between NO and mycothiol levels confirmed that mycothiol is important for protecting mycobacteria from NO attack.
Miller
Christopher C
CC
Department of Medicine, Division of Infectious Diseases, University of British Columbia, 2733 Heather St., Vancouver, BC, Canada V5Z 3J5.
Rawat
Mamta
M
Johnson
Todd
T
Av-Gay
Yossef
Y
D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000494:pharmacology*; D003545:Cysteine / Q000378:metabolism / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics; D005798:Genes, Bacterial; D006020:Glycopeptides / Q000378:metabolism / Q000494:pharmacology*; D007294:Inositol / Q000378:metabolism / Q000494:pharmacology*; D009154:Mutation; D020102:Mycobacterium smegmatis / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C089265:mycothiol; D009569:Nitric Oxide; D007294:Inositol; D003545:Cysteine