Chimeric T helper-B cell peptides induce protective response against Japanese encephalitis virus in mice.
Virus neutralizing MAb binding and T helper cell stimulating peptide epitopes from structural and non-structural proteins of Japanese encephalitis virus were delineated. It was observed that priming by T helper peptides potentiated neutralizing antibody response against JE virus. Immunization with chimeric T helper - B cell peptides could thus protect mice from lethal challenge with JE virus.
Dewasthaly
Shailesh Shyam
SS
National Institute of Virology, Pune 411 001, India.
Bhonde
Gauri Sanjay
GS
Shankarraman
Vasudha
V
Biswas
S Moanaro
SM
Ayachit
Vijay Madhukar
VM
Gore
Milind Madhukar
MM
D019264:Adoptive Transfer; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D004664:Encephalitis Virus, Japanese / Q000276:immunology; D004672:Encephalitis, Japanese / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D018985:Epitopes, B-Lymphocyte / Q000737:chemistry / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry / Q000276:immunology; D007111:Immunity, Cellular; D022321:Japanese Encephalitis Vaccines / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology* / Q000378:metabolism; D022223:Vaccines, Subunit / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D022321:Japanese Encephalitis Vaccines; D010455:Peptides; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic