[The effect of arginine and its metabolites on tissue culture of rat myocardium].
In was demonstrated using the method of organotypic culture that arginine and its metabolites: cutrulline, ornitine and especially urea, in ultralow doses stimulated the myocardium proliferation in mature rats. Only nitric oxide (NO) possessed the antiproliferative effect. The cytrulline effect was similar to the arginine effect. The metabolism of these amino acids is intimately interrelated so the cytrulline can be used in the clinic practice as an "argininepreserved" preparation. The antiproliferative NO effect can be delayed by thiole-containing preparations: glulathione and unithiole.
Chalisova
N I
NI
Zakutskiĭ
A N
AN
Aniskina
A I
AI
D000603:Amino Acids, Sulfur / Q000494:pharmacology; D000818:Animals; D001120:Arginine / Q000378:metabolism / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002956:Citrulline / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D020030:Nitric Oxide Donors / Q000494:pharmacology; D005996:Nitroglycerin / Q000494:pharmacology; D009952:Ornithine / Q000494:pharmacology*; D051381:Rats; D046509:Tissue Culture Techniques; D014508:Urea / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D020030:Nitric Oxide Donors; D002956:Citrulline; D009569:Nitric Oxide; D014508:Urea; D001120:Arginine; D009952:Ornithine; D005996:Nitroglycerin