Complete 1H and 13C NMR assignments and anti fungal activity of two 8-hydroxy flavonoids in mixture.
A mixture of the two new flavonols 8-hydroxy-3, 4', 5, 6, 7-pentamethoxyflavone (1) and 8-hydroxy-3, 3', 4', 5, 6, 7-hexamethoxyflavone (2) was isolated from a commercial sample of Citrus aurantifolia. An array of one- (1HNMR, {1H}-13C NMR, and APT-13C NMR) and two-dimensional NMR techniques (COSY, NOESY, HMQC and HMBC) was used to achieve the structural elucidation and the complete 1H and 13C chemical shift assignments of these natural compounds. In addition, the antifungal activity of these compounds against phytopathogenic and human pathogenic fungi was investigated.
Johann
Susana
S
Laboratório de Antibióticos, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-970, Brazil.
Smânia
Artur
A
Pizzolatti
Moacir G
MG
Schripsema
Jan
J
Braz-Filho
Raimundo
R
Branco
Alexsandro
A
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032082:Citrus aurantiifolia / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
C524568:8-hydroxy-3,3',4',5,6,7-hexamethoxyflavone; C524567:8-hydroxy-3,4',5,6,7-pentamethoxyflavone; D000935:Antifungal Agents; D047309:Flavones