Evaluation of four whole-cell Leptospira-based serological tests for diagnosis of urban leptospirosis.
Four serologic assays for leptospirosis had sensitivities of 72 to 88% and specificities of 88 to 100% in the setting of highly endemic urban transmission, indicating that assays using enzyme-linked immunosorbency and rapid formats may be used as alternatives to the microscopic agglutination test for diagnosing urban leptospirosis. Testing a second sample will be required in cases with an initial negative result, since sensitivity was low (46 to 68%) during the first week of illness.
McBride
Alan J A
AJ
Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil.
Santos
Balbino L
BL
Queiroz
Adriano
A
Santos
Andréia C
AC
Hartskeerl
Rudy A
RA
Reis
Mitermayer G
MG
Ko
Albert I
AI
D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007919:Leptospira / Q000276:immunology*; D007922:Leptospirosis / Q000175:diagnosis* / Q000276:immunology / Q000635:transmission; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods / Q000592:standards