Triplet pregnancy after metformin in a woman with polycystic ovary syndrome.
OBJECTIVE
To report a case of triplet pregnancy after metformin treatment only, in a woman with polycystic ovary syndrome (PCOS) and a family history of twin pregnancies.


METHODS
Case report and literature review.


METHODS
Gynecologic endocrinology clinic, tertiary federal hospital.


METHODS
A white, lean, 34-year-old woman, treated for PCOS since age 28, who had tried to conceive spontaneously for 6 months, with no evidence of ovulation.


METHODS
Metformin, 850 mg, for 1.5 months.


METHODS
Pregnancy (triplet).


RESULTS
Pregnancy developed up to premature labor at 31 weeks. The patient delivered two boys and one girl, in need of neonatal intensive care for 33 to 44 days.


CONCLUSIONS
Despite the paucity of literature data, we believe that metformin, when associated with predisposing therapies or conditions, may facilitate high-order pregnancies.
Clapauch
Ruth
R
Gynecological Endocrinology Sector, Internal Medicine Service, Hospital da Lagoa, Health Ministry, Rio de Janeiro, Brazil. Electronic address: rclapauch@uol.com.br.
Mattos
Tatiana M
TM
Gynecological Endocrinology Sector, Internal Medicine Service, Hospital da Lagoa, Health Ministry, Rio de Janeiro, Brazil.
D000328:Adult; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007247:Infertility, Female / Q000209:etiology; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D016896:Treatment Outcome; D014310:Triplets
D007004:Hypoglycemic Agents; D008687:Metformin