Mitotic motors: kinesin-5 takes a brake.
A kinesin-5-dependent 'sliding filament' mechanism is commonly used to actively push apart the poles during mitotic spindle assembly and elongation, but a recent study now shows that, in C. elegans, kinesin-5 is deployed as a brake to slow down spindle-pole separation.
Civelekoglu-Scholey
Gul
G
Department of Molecular and Cell Biology, University of California at Davis, Davis, CA 95616, USA. jmscholey@ucdavis.edu
Scholey
Jonathan M
JM
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D016547:Kinesins / Q000502:physiology*; D008938:Mitosis / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology*
D016547:Kinesins