title: Lecythophora mutabilis prosthetic valve endocarditis in a diabetic patient.
abstract: While dematiaceous (dark-walled) fungi are ubiquitous in the environment, their involvement in invasive human infections has rarely been reported. However, these organisms have been identified as potential emerging pathogens, particularly among immunocompromised hosts. We describe a diabetic patient with Lecythophora mutabilis prosthetic valve endocarditis who was treated surgically, as well as with amphotericin B lipid complex and voriconazole, which were subsequently followed by prolonged voriconazole suppressive therapy. To the best of our knowledge, our patient is the first reported survivor of L. mutabilis prosthetic valve endocarditis.
authors.affiliation: Division of Geographic Medicine & Infectious Diseases, Department of Medicine, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA.
authors.forename: Marci
authors.initials: M
authors.lastname: Drees
authors.forename: Brian L
authors.initials: BL
authors.lastname: Wickes
authors.forename: Mamta
authors.initials: M
authors.lastname: Gupta
authors.forename: Susan
authors.initials: S
authors.lastname: Hadley
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001021:Aortic Valve / Q000601:surgery; D001203:Ascomycota / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D048909:Diabetes Complications; D004338:Drug Combinations; D004696:Endocarditis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D006350:Heart Valve Prosthesis / Q000009:adverse effects / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D010713:Phosphatidylcholines / Q000627:therapeutic use; D010715:Phosphatidylglycerols / Q000627:therapeutic use; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D011743:Pyrimidines / Q000627:therapeutic use; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D011743:Pyrimidines; D014230:Triazoles; C068538:liposomal amphotericin B; D000666:Amphotericin B; D065819:Voriconazole