title: A retrospective and comparative study of familial and non-familial bullous lichen planus.
abstract: In order to compare the clinical characteristics of familial and non-familial bullous lichen planus (BLP), the archival data of 36 BLP patients with positive family history and 21 BLP patients with negative family history diagnosed according to the clinical features and histopathology were collected in our department from 1956 to 2003. The clinical features were analyzed and compared. There were significant differences between familial and non-familial BLP in age of onset, duration of disease and extension of eruption (P<0.01). It was concluded that familial BLP appeared to differ from the non-familial form in its earlier age of onset, longer duration of the disease, more extensive eruption and more tendency to involve nails. Hereditary factors may play a role in the pathogenesis of familial BLP.
authors.affiliation: Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. hcz0501@126.com
authors.forename: Changzheng
authors.initials: C
authors.lastname: Huang
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Yan
authors.forename: Lingyun
authors.initials: L
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Tian
authors.forename: Jiawen
authors.initials: J
authors.lastname: Li
authors.forename: Chunsen
authors.initials: C
authors.lastname: Wang
authors.forename: Yating
authors.initials: Y
authors.lastname: Tu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D008010:Lichen Planus / Q000145:classification / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies