title: New insights into the macronuclear development in ciliates.
abstract: During macronuclear differentiation in ciliated protozoa, most amazing "DNA gymnastics" takes place, which includes DNA excision, DNA elimination, DNA reorganization, and DNA-specific amplification. Although the morphological events occurring during macronuclear development are well described, a detailed knowledge of the molecular mechanisms and the regulation of this differentiation process is still missing. However, recently several models have been proposed for the molecular regulation of macronuclear differentiation, but these models have yet to be verified experimentally. The scope of this review is to summarize recent discoveries in different ciliate species and to compare and discuss the different models proposed. Results obtained in these studies are not only relevant for our understanding of nuclear differentiation in ciliates, but also for cellular differentiation in eukaryotic organisms in general as well as for other disciplines such as bioinformatics and computational biology.
authors.affiliation: Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, Rockefeller University, New York, New York 10021, USA.
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Juranek
authors.forename: Hans Joachim
authors.initials: HJ
authors.lastname: Lipps
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D016798:Ciliophora / Q000235:genetics* / Q000502:physiology* / Q000648:ultrastructure; D053938:DNA Fragmentation; D016054:DNA, Protozoan / Q000378:metabolism*; D018503:Genome, Protozoan; D048648:Macronucleus / Q000235:genetics / Q000502:physiology*
chemical_list: D016054:DNA, Protozoan