title: Antimicrobial resistance of Vibrio cholerae O1 serotype Ogawa isolated in Manhiça District Hospital, southern Mozambique.
abstract: OBJECTIVE
  To describe the antimicrobial susceptibility profile of isolated Vibrio cholerae O1 serotype Ogawa recovered from patients admitted to the cholera facility in the Manhiça District Hospital (MDH), Mozambique.
  
  
  METHODS
  Rectal swabs were collected from patients with complaints symptomatic of cholera admitted to the MDH cholera facility. Samples were processed for V. cholerae isolation at the Centro de Investigação em Saúde da Manhiça (CISM) and identified by biochemical reaction. Serotypes were determined by slide-agglutination antisera. Susceptibilities were determined by disc diffusion.
  
  
  RESULTS
  Seventy-seven isolates were examined for their resistance profile. High incidences of antimicrobial resistance were found for chloramphenicol (57.9%), co-trimoxazole (96.6%) and tetracycline (97.3%). Quinolone resistance remained low (4.2%).
  
  
  CONCLUSIONS
  Although V. cholerae infections in Africa do not usually require antimicrobial treatment, strains in rural Mozambique show high incidences of resistance to readily available drugs. When appropriate, quinolones or third-generation cephalosporins can be used as treatment options.
authors.affiliation: Centro de Investigação em Saúde da Manhiça (CISM), Maputo, Mozambique. inacio.mandomando@manhica.net
authors.forename: Inácio
authors.initials: I
authors.lastname: Mandomando
authors.forename: Mateu
authors.initials: M
authors.lastname: Espasa
authors.forename: Xavier
authors.initials: X
authors.lastname: Vallès
authors.forename: Jahit
authors.initials: J
authors.lastname: Sacarlal
authors.forename: Betuel
authors.initials: B
authors.lastname: Sigaúque
authors.forename: Joaquim
authors.initials: J
authors.lastname: Ruiz
authors.forename: Pedro
authors.initials: P
authors.lastname: Alonso
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002771:Cholera / Q000382:microbiology*; D003627:Data Interpretation, Statistical; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009073:Mozambique; D012007:Rectum / Q000382:microbiology; D012424:Rural Population; D041241:Vibrio cholerae O1 / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents