title: [Coating with plasma-deposited functionalized diamond-like carbon to decrease encrustations on urological implants].
abstract: The double-J stents used today for palliative artificial urinary diversion very often show extreme formation of encrustations, even a short time after implantation. Despite increased scientific material development, the complication rate has not really been strongly influenced. Grant-aided by the German Federal Ministry of Education and Research, we chose a new interdisciplinary and translational approach by coating standard stent materials with plasma-deposited amorphous diamond-like carbon. These stents show clearly reduced rates of encrustation in vitro. Ongoing clinical trials demonstrate a further enhancement of this effect in vivo. The underlying mechanisms are being investigated by extending the established in vitro model, thereby pushing research in this field to a new level.
authors.affiliation: Klinik und Poliklinik für Urologie, Universitätsklinikum, Sigmund-Freud-Strasse 25, 53125 Bonn. norbert.laube@ukb.uni-bonn.de
authors.forename: N
authors.initials: N
authors.lastname: Laube
authors.forename: L
authors.initials: L
authors.lastname: Kleinen
authors.forename: U
authors.initials: U
authors.lastname: Böde
authors.forename: C
authors.initials: C
authors.lastname: Fisang
authors.forename: A
authors.initials: A
authors.lastname: Meissner
authors.forename: J
authors.initials: J
authors.lastname: Bradenahl
authors.forename: I
authors.initials: I
authors.lastname: Syring
authors.forename: H
authors.initials: H
authors.lastname: Busch
authors.forename: W
authors.initials: W
authors.lastname: Pinkowski
authors.forename: S C
authors.initials: SC
authors.lastname: Müller
mesh_terms: D000818:Animals; D018441:Biofilms / Q000254:growth & development*; D002244:Carbon; D020099:Coated Materials, Biocompatible; D003460:Crystallization; D019276:Glycocalyx; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver; D008422:Materials Testing; D010710:Phosphates; D010949:Plasma; D011140:Polyurethanes; D019736:Prostheses and Implants; D015607:Stents; D013552:Swine; D014547:Urinary Diversion / Q000295:instrumentation*; D014556:Urine
chemical_list: D020099:Coated Materials, Biocompatible; D010710:Phosphates; D011140:Polyurethanes; D002244:Carbon