title: The ideal small arterial substitute: Role of cell seeding and tissue engineering.
abstract: Although autogenous vessels are useful in surgery, often patients cannot furnish suitable vessels. If there are not available, two possible alternatives for vessel replacements are to use vascular synthetic prostheses such as Dacron((R)) and polytetrafluoroethylene (PTFE) or cryopreserved allografts. However, their success has been limited to replace small-diameter (<6 mm) arterial vessel because of their high thrombogenicity and compliance mismatch. On account of a clear clinical need for a functional arterial substitute, tissue engineering techniques have been developed. This review encompasses the use of mature endothelial, endothelial progenitor and bone marrow cells combined with natural or synthetic scaffolds whose surface has been modified with multiple origin matrices.
authors.affiliation: Mécanique et Ingénierie Cellulaire et Tissulaire, LEMTA-UMR 7563, IFR 111, Faculté de Médecine Université Henry Poincaré, 54505 Vandoeuvre-lès-Nancy, France. halima.kerdjoudj@medecine.uhp-nancy.fr
authors.forename: Halima
authors.initials: H
authors.lastname: Kerdjoudj
authors.forename: Vanessa
authors.initials: V
authors.lastname: Moby
authors.forename: Nicolas
authors.initials: N
authors.lastname: Berthelemy
authors.forename: Monique
authors.initials: M
authors.lastname: Gentils
authors.forename: Cédric
authors.initials: C
authors.lastname: Boura
authors.forename: Laurence
authors.initials: L
authors.lastname: Bordenave
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Stoltz
authors.forename: Patrick
authors.initials: P
authors.lastname: Menu
mesh_terms: D001807:Blood Vessel Prosthesis; D001854:Bone Marrow Cells / Q000166:cytology; D018929:Cell Culture Techniques; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D011108:Polymers / Q000627:therapeutic use; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*; D014182:Transplantation, Autologous
chemical_list: D011108:Polymers