title: [Non-invasive detection of liver fibrosis in patients with chronic hepatitis C].
abstract: BACKGROUND
  The aim of study, which was supported by grant IGA MZ CR NR 7814-3, was to determine sensitivity of serum tests APRI, test of liver fibrosis according Forns and alpha2macroglobulin in detection of liver fibrosis.
  
  
  RESULTS
  The cohort study included 30 patients with chronic hepatitis C, all were infected HCV genotype 1a or 1b. Liver biopsy specimen was evaluated by one pathologist and liver fibrosis was classified according Battes-Ludwig.
  
  
  CONCLUSIONS
  Statistically significant correlation of APRI and alpha2macroglobulin with the stage of fibrosis was identified; while there was no statistically significant sensitivity of Forns test of liver fibrosis.
authors.affiliation: II. interni klinika LF a FN, Olomouc aiglovi@volny.cz
authors.forename: K
authors.initials: K
authors.lastname: Aiglová
authors.forename: J
authors.initials: J
authors.lastname: Ehrmann
authors.forename: J
authors.initials: J
authors.lastname: Ehrmann
mesh_terms: D000328:Adult; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001707:Biopsy, Needle; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000473:pathology / Q000821:virology*; D008297:Male; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D015415:Biomarkers; D000511:alpha-Macroglobulins; D001219:Aspartate Aminotransferases