title: To compare the efficacy of two doses of intraperitoneal bupivacaine for pain relief after operative laparoscopy in gynecology.
abstract: OBJECTIVE
  To evaluate the effect of two doses of intraperitoneal bupivacaine administration for pain relief after operative gynecological laparoscopy.
  
  
  METHODS
  Prospective randomized study.
  
  
  METHODS
  The study group comprised 52 women undergoing gynecological laparoscopic surgery. A dose of either 0.125% bupivacaine 10 ml (50 mg) or 0.25% bupivacaine (100 mg) was instilled intraperitoneally at the end of the procedure. Pain scores were recorded in the postoperative period on a scale of 0-10 at 2, 4, 6 and 8 h intervals after the surgery. Any other side effect and the time and dose of analgesia required were noted. The results were compared in the two groups.
  
  
  RESULTS
  One hundred milligrams of bupivacine provided pain relief for a longer duration (8 h), as compared to 50 mg of the drug (4-6 h). This difference was statistically significant. Analgesic requirement was also less in the 100 mg group.
  
  
  CONCLUSIONS
  One hundred milligrams of intraperitoneal bupivacaine is much better than 50 mg in relieving pain after laparoscopic surgery.
authors.affiliation: Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Neena
authors.initials: N
authors.lastname: Malhotra
authors.forename: Charu
authors.initials: C
authors.lastname: Chanana
authors.forename: Kallol K
authors.initials: KK
authors.lastname: Roy
authors.forename: Sunesh
authors.initials: S
authors.lastname: Kumar
authors.forename: Vimi
authors.initials: V
authors.lastname: Rewari
authors.forename: Vimmi
authors.initials: V
authors.lastname: Riwari
authors.forename: J B
authors.initials: JB
authors.lastname: Sharma
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002045:Bupivacaine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D007274:Injections, Intraperitoneal; D010535:Laparoscopy; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine