Susceptibility of naïve and subsets of memory T cells to apoptosis via multiple signaling pathways.
Apoptosis is mediated via death receptor, the mitochondrial, and the endoplasmic reticulum pathway. Following activation of naïve T cells with antigens, different subsets of memory T cells are generated. In this review we have discussed relative sensitivity/resistance of naïve and different subsets of memory T cells to apoptosis via different signaling pathways. Molecular basis for differential sensitivity to apoptosis is discussed.
Gupta
Sudhir
S
Division of Basic and Clinical Immunology, Medical Sciences I, C-240, University of California, Irvine, CA 92697, USA. sgupta@uci.edu
Gollapudi
Sastry
S
D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004721:Endoplasmic Reticulum / Q000502:physiology; D006801:Humans; D007156:Immunologic Memory; D008928:Mitochondria / Q000502:physiology; D053218:Receptors, Death Domain / Q000502:physiology; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D053218:Receptors, Death Domain