title: Neurogliovascular unit after cerebral ischemia: is the vascular wall a pharmacological target.
abstract: Ischemic stroke induces drastic alterations of the functions of the neurogliovascular unit with dramatic consequences on the well-being of the patients in terms of cognitive and motor handicap. Nowadays, only very few therapeutics are available as a treatment of ischemic stroke. Ischemia is a multifactorial pathology involving different cerebral cellular components such as neurons, astrocytes and vessels working as a functional unit. Recent experimental strategy investigation involving different agents with antioxidant properties (dt-BC, stobadine) or pleiotropic effects (lipopolysaccharide, LPS) has been developed to evaluate whether the vascular wall could be considered as a potential target in neuroprotection concept.
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, 1, Place de Verdun, 59045 Lille Cedex, France. michele.bastide@univ-lille1.fr
authors.forename: M
authors.initials: M
authors.lastname: Bastide
authors.forename: T
authors.initials: T
authors.lastname: Ouk
authors.forename: F
authors.initials: F
authors.lastname: Plaisier
authors.forename: O
authors.initials: O
authors.lastname: Pétrault
authors.forename: S
authors.initials: S
authors.lastname: Stolc
authors.forename: R
authors.initials: R
authors.lastname: Bordet
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D042783:Endothelial Cells / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D011188:Potassium / Q000378:metabolism; D051381:Rats; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control
chemical_list: D018696:Neuroprotective Agents; D011188:Potassium