title: [Association among lipids, leptin and leptin receptor polymorphisms with risk of breast cancer].
abstract: OBJECTIVE
  To evaluate the association between serum level of leptin and leptin receptor gene (LEPR) polymorphism and patients with breast cancer.
  
  
  METHODS
  LEPR G1n223Arg polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 94 patients with breast cancer and 128 healthy controls. The level of leptin were analyzed by enzyme linked immunosorbent assay.
  
  
  RESULTS
  In univariate regression analyses, we found serum level of leptin and LEPR Gin223Arg genotype polymorphism were significantly higrer than those of the controls (P < 0.05-0.001, respectively). Through multivariable analyses, we found that increased risk estimates for breast cancer were among those with leptin level (OR = 1.53, 95% CI: 1.13-2.07, P = 0.006), LEPR Gin223Arg genotype (OR = 4.87, 95%CI:1.30-18.22, P = 0.019), WHR (OR = 3.68, 95% CI: 1.34-10.11, P = 0.011).
  
  
  CONCLUSIONS
  Results from this study suggested that LEPR Gln233Agr polymorphism, the elevated WHR and serum level of leptin might be correlated with increased risk of breast cancer.
authors.affiliation: Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China.
authors.forename: Cun-zhi
authors.initials: CZ
authors.lastname: Han
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: Li-li
authors.initials: LL
authors.lastname: Du
authors.forename: Jie-xian
authors.initials: JX
authors.lastname: Jing
authors.forename: Xian-wen
authors.initials: XW
authors.lastname: Zhao
authors.forename: Bao-guo
authors.initials: BG
authors.lastname: Tian
authors.forename: Fu-guo
authors.initials: FG
authors.lastname: Tian
authors.forename: Xiu-ying
authors.initials: XY
authors.lastname: Liu
authors.forename: Zhong-shu
authors.initials: ZS
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
mesh_terms: D001943:Breast Neoplasms / Q000097:blood* / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D011110:Polymorphism, Genetic; D054411:Receptors, Leptin / Q000235:genetics*; D012306:Risk
chemical_list: C515448:LEPR protein, human; D020738:Leptin; D008055:Lipids; D054411:Receptors, Leptin