title: [Replication of pathological scar in nude mice].
abstract: OBJECTIVE
  To investigate the feasibility of reproduce hypertrophic scar and keloid in nude mice in the study of pathological scars.
  
  
  METHODS
  Pieces (0.8 x 0.8 x 0.5 cm) of hypertrophic scars and keloids were implanted into subcutaneous tissue of the nude mice for 16 days, during this period the gross condition of the nude mice and the state of the implants were observed. The implants were extracted after 16 days, and the volume, the microscopic characteristics of the scar, the content of acid mucopolysaccharide, and different types of collagen were determined and compared with that of the original specimens.
  
  
  RESULTS
  All mice survived with nice wound healing after the surgery. There was no obvious difference in the acid mucopolysaccharide content in keloid and hyperplastic scar before implantation (3448 +/- 1452, 1940 +/- 509), and after implantation (3237 +/- 1871, 1809 +/- 552, P > 0.05). The implants maintained the collagen pattern, with no signs of cell degeneration and necrosis.
  
  
  CONCLUSIONS
  This experiment showed that the viability and morphology of hypertrophic scars and keloids were maintained after they were implanted in nude mice. Therefore it is feasible to use nude mice as the animal model in the study of hypertrophic scars and keloids.
authors.affiliation: Department of Burns and Plastic Surgery, West China Hospital of Sichuan University, Chengdu 610041, P. R. China.
authors.forename: Pei-Sheng
authors.initials: PS
authors.lastname: Jin
authors.forename: Ying
authors.initials: Y
authors.lastname: Cen
authors.forename: Xiao-Xue
authors.initials: XX
authors.lastname: Liu
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Chen
authors.forename: Xue-Wen
authors.initials: XW
authors.lastname: Xu
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Li
authors.forename: Yaojun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D017439:Cicatrix, Hypertrophic / Q000473:pathology*; D004195:Disease Models, Animal; D007627:Keloid / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude