title: A concise asymmetric synthesis of torcetrapib.
abstract: Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.
authors.affiliation: Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, United Kingdom.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Guinó
authors.forename: Pim Huat
authors.initials: PH
authors.lastname: Phua
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Caille
authors.forename: King Kuok Mimi
authors.initials: KK
authors.lastname: Hii
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002219:Carbamates / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013997:Time Factors
chemical_list: D000596:Amino Acids; D002219:Carbamates; D011804:Quinolines; C483909:torcetrapib