title: Automated liquid-liquid extraction workstation for library synthesis and its use in the parallel and chromatography-free synthesis of 2-alkyl-3-alkyl-4-(3H)-quinazolinones.
abstract: An automated liquid-liquid extraction workstation has been developed. This module processes up to 96 samples in an automated and parallel mode avoiding the time-consuming and intensive sample manipulation during the workup process. To validate the workstation, a highly automated and chromatography-free synthesis of differentially substituted quinazolin-4(3H)-ones with two diversity points has been carried out using isatoic anhydride as starting material.
authors.affiliation: Centro de Investigación Lilly, S. A, Avenida de la Industria 30, 28108-Alcobendas, Madrid, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Carpintero
authors.forename: Marta
authors.initials: M
authors.lastname: Cifuentes
authors.forename: Rafael
authors.initials: R
authors.lastname: Ferritto
authors.forename: Rubén
authors.initials: R
authors.lastname: Haro
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Toledo
mesh_terms: D001331:Automation; D002853:Chromatography, Liquid / Q000295:instrumentation*; D009682:Magnetic Resonance Spectroscopy; D052999:Quinazolinones / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D052999:Quinazolinones