title: Sliced inverse regression with regularizations.
abstract: In high-dimensional data analysis, sliced inverse regression (SIR) has proven to be an effective dimension reduction tool and has enjoyed wide applications. The usual SIR, however, cannot work with problems where the number of predictors, p, exceeds the sample size, n, and can suffer when there is high collinearity among the predictors. In addition, the reduced dimensional space consists of linear combinations of all the original predictors and no variable selection is achieved. In this article, we propose a regularized SIR approach based on the least-squares formulation of SIR. The L2 regularization is introduced, and an alternating least-squares algorithm is developed, to enable SIR to work with n < p and highly correlated predictors. The L1 regularization is further introduced to achieve simultaneous reduction estimation and predictor selection. Both simulations and the analysis of a microarray expression data set demonstrate the usefulness of the proposed method.
authors.affiliation: Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA. li@stat.ncsu.edu
authors.forename: Lexin
authors.initials: L
authors.lastname: Li
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Yin
mesh_terms: D000465:Algorithms; D001699:Biometry / Q000379:methods*; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D004812:Epidemiologic Methods; D016018:Least-Squares Analysis; D008954:Models, Biological; D015233:Models, Statistical; D012044:Regression Analysis