title: Iron signaling and oxidant damage.
abstract: In this brief essay we discuss the interrelationship between the cellular signaling effects induced by extracellular and intracellular ROS and nitric oxide in the context of doxorubicin (DOX) toxicity.
authors.affiliation: Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, USA. balarama@mcw.edu
authors.forename: Balaraman
authors.initials: B
authors.lastname: Kalyanaraman
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D004317:Doxorubicin / Q000633:toxicity; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity; D007501:Iron / Q000502:physiology*; D009569:Nitric Oxide / Q000502:physiology; D016877:Oxidants / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D011990:Receptors, Transferrin / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
chemical_list: D000903:Antibiotics, Antineoplastic; D016877:Oxidants; D011990:Receptors, Transferrin; D009569:Nitric Oxide; D004317:Doxorubicin; D006861:Hydrogen Peroxide; D007501:Iron