[A case of recurrent esophageal cancer successfully treated with concurrent radiochemotherapy with low-dose docetaxel plus 5-FU].
A 70-year-old woman, who had undergone esophagectomy for cervical esophageal squamous cell carcinoma (pT3pN2M0, Stage III) 9 months earlier, was diagnosed as mediastinal lymph node recurrence by CT and endoscope. Patients underwent radiochemotherapy with 5 cycles of docetaxel 10 mg/m(2) on day 1 and 5-FU 250 mg/m(2) on day 1 to day 5, together with concurrent radiation (50 Gy/25 Fr) for mediastinum. After this treatment, a complete response (CR) was achieved, and there was no recurrence 9 months after the treatment. No severe adverse effects were observed. Concurrent radiochemotherapy with docetaxel and 5-FU is considered effective without serious side effects for postoperative recurrence in esophageal cancer.
Shibata
Tomotaka
T
Surgery II, Dept. of Oncological Science, Faculty of Medicine, Oita University.
Takeno
Shinsuke
S
Watanabe
Satoshi
S
Fumoto
Shoichi
S
Takahashi
Yoshiaki
Y
Noguchi
Tsuyoshi
T
Kawahara
Katsunobu
K
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008482:Mediastinum; D012074:Remission Induction; D043823:Taxoids / Q000008:administration & dosage
D043823:Taxoids; D000077143:Docetaxel; D005472:Fluorouracil