title: Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus.
abstract: The patient was a 57-year-old white woman who presented with a 3.0 x 2.0-cm partially ulcerated vaginal polyp. Histology revealed a malignant mixed mullerian tumor composed of invasive squamous cell carcinoma with deeper areas of undifferentiated pleomorphic sarcoma. Invasive carcinoma had overlying high-grade vaginal intraepithelial neoplasia (VaIN III), which contained koilocytic atypia. In situ hybridization detected high-risk human papillomavirus DNA in both the carcinoma and the sarcoma components.
authors.affiliation: North Broward Medical Center, Deerfield Beach, FL 33064, USA. msebenik@yahoo.com
authors.forename: Matjaz
authors.initials: M
authors.lastname: Sebenik
authors.forename: Zhijije
authors.initials: Z
authors.lastname: Yan
authors.forename: Walid E
authors.initials: WE
authors.lastname: Khalbuss
authors.forename: Khush
authors.initials: K
authors.lastname: Mittal
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008875:Middle Aged; D018200:Mixed Tumor, Mullerian / Q000737:chemistry / Q000473:pathology* / Q000601:surgery / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology*; D012509:Sarcoma / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery / Q000821:virology
chemical_list: D014408:Biomarkers, Tumor; D004279:DNA, Viral