[Morphology and peculiarities of proliferation of polypoid formations of the large bowel].
Seventy-five polypoid formations of the large bowel identified as different varieties (T.Yamada) were examined microscopically and immunohistochemically. The latter procedure was used to identify antigen Ki-67 and investigate their proliferative features. Although, according to T.Yamada, gastro-intestinal polyps are described with respect to shape and size of polypoid lesion only, microscopic structure of polyps manages to find its reflection to a considerable degree too: type I predominantly embraces hypertrophic folds of mucosa as well as non-tumor polyps, both hyperplastic and inflammatory, while, at more advanced stages (II-IV), tubular and tubulo-villose adenomas and villose tumors prevail. Adenomas reveal slightly increased proliferative activity (enhanced Ki-67) as compared with intact mucosa whereas most changes are limited to change of localization of proliferating enterocytes. Proliferating elements occur in the superficial strata of tumor rather than in the bottom third of the mucosal crypt. Thus a great potential for tumorigenesis is created.
Kudrevatykh
S S
SS
Ten
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VP
D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D049109:Cell Proliferation; D003111:Colonic Polyps / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged
D019394:Ki-67 Antigen