title: Office work exposures and adult-onset asthma.
abstract: BACKGROUND
  Office exposures have been linked to symptoms of sick building syndrome, but their relation to the development of asthma has not been studied previously. These exposures have increasing importance because an increasing proportion of the workforce is working in office environments.
  
  
  OBJECTIVE
  The aim of this study was to assess the relations of exposure to carbonless copy paper (CCP), paper dust, and fumes from photocopiers and printers to adult-onset asthma.
  
  
  METHODS
  We conducted a population-based incident case-control study of adults 21-63 years of age living in the Pirkanmaa District in South Finland. All new clinically diagnosed cases (n = 521) of asthma were recruited during a 3-year study period. A random sample of the source population formed the controls (n = 1,016). This part focused on 133 cases and 316 controls who were office workers according to their current occupation classified by the 1988 International Standard Classification of Occupations. All participants answered a questionnaire on health, smoking, occupation, and exposures at work and home. Subjects with previous asthma were excluded.
  
  
  RESULTS
  Exposures to paper dust [adjusted odds ratio (OR) = 1.97; 95% confidence interval (CI), 1.25-3.10] and CCP (OR = 1.66; 95% CI, 1.03-2.66) were related to significantly increased risk of adult-onset asthma. An exposure-response relation was observed between exposure to paper dust and risk of asthma.
  
  
  CONCLUSIONS
  This study provides new evidence that exposures to paper dust and CCP in office work are related to increased risk of adult-onset asthma. Reduction of these exposures could prevent asthma in office workers. Clinicians seeing asthma patients should be aware of this link to office exposures.
authors.affiliation: Institute of Occupational and Environmental Medicine, University of Birmingham, Birmingham, United Kingdom. M.Jaakkola@bham.ac.uk
authors.forename: Maritta S
authors.initials: MS
authors.lastname: Jaakkola
authors.forename: Jouni J K
authors.initials: JJ
authors.lastname: Jaakkola
mesh_terms: D000328:Adult; D017668:Age of Onset; D001249:Asthma / Q000453:epidemiology*; D016022:Case-Control Studies; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D016273:Occupational Exposure