[Coagulation disorders in cirrhosis].
The liver plays a central role in the clotting process. In this organ are sintetizated the major part of the coagulation factors. Historically, was considered that alteration in liver function causes important bleeding disorders. However, actual evidence is not in agreement with this asseveration. Decreased synthesis of clotting and inhibitor factors, decrease clearance of activated factors, quantitative and qualitative platelet defects, hyperfibrinolysis and intravascular coagulation are some of the defects observed in liver diseases. Thrombotic events, even if rare in cirrhotic patients, occur manly in the portal and mesenteric veins. The aim of the present work is to review the present evidence in coagulation disorders and liver disease.
Téllez-Avila
Felix I
FI
Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, México, D F.
Chávez-Tapia
Norberto C
NC
Torre-Delgadillo
Aldo
A
D000347:Afibrinogenemia / Q000209:etiology; D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000503:physiopathology; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D001792:Blood Platelets / Q000502:physiology; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000503:physiopathology; D005342:Fibrinolysis; D006474:Hemorrhagic Disorders / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D008642:Mesenteric Veins; D011169:Portal Vein; D019851:Thrombophilia / Q000209:etiology / Q000503:physiopathology; D013926:Thrombopoietin / Q000096:biosynthesis / Q000172:deficiency; D013927:Thrombosis / Q000209:etiology; D014813:Vitamin K Deficiency / Q000209:etiology
D001779:Blood Coagulation Factors; D013926:Thrombopoietin