title: Anaplastic variant of spermatocytic seminoma.
abstract: We report a case of a 56-year-old male with an anaplastic variant of spermatocytic seminoma of the left testis. Grossly, the tumor measured 10 x 7.5 x 6.5 cm and consisted of soft grayish-white tissue, which varied from fleshy to gelatinous with formation of some pseudocysts. Histologically, the tumor was composed of the areas of typical spermatocytic seminoma; however, in some areas, the intermediate and large tumor cells showed prominent nucleoli. In another part of the tumor, we noted anaplastic areas composed of sheets of tumor cells with large vesicular nuclei and prominent nucleoli. Tunical and vascular invasion as well as growth into the epididymis were noted. Immunohistochemically, the tumor cells showed only weak positivity for CD117, the other markers examined were negative.
authors.affiliation: Institute of Pathology, 1st Faculty of Medicine and General Faculty Hospital, Charles University, Studnickova 2, Prague 128 00, Czech Republic. pdundr@seznam.cz
authors.forename: Pavel
authors.initials: P
authors.lastname: Dundr
authors.forename: Michael
authors.initials: M
authors.lastname: Pesl
authors.forename: Ctibor
authors.initials: C
authors.lastname: Povýsil
authors.forename: Petra
authors.initials: P
authors.lastname: Prokopová
authors.forename: Ivan
authors.initials: I
authors.lastname: Pavlík
authors.forename: Viktor
authors.initials: V
authors.lastname: Soukup
authors.forename: Jan
authors.initials: J
authors.lastname: Dvorácek
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D018239:Seminoma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D013736:Testicular Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin; D019009:Proto-Oncogene Proteins c-kit