title: [A case-control study on the risk factors for attempted suicide in patients with major depression].
abstract: OBJECTIVE
  To understand the environmental risk factors on attempted suicide in patients with major depression, and to study the interaction between factors as single nucleotide polymorphism(SNP) of TPH2 gene rs7305115 associated to attempted suicide in major depression.
  
  
  METHODS
  Paired case-control study on 215 suicide attempters with major depression (92 male, 123 female) and molecular biological techniques were used to study the relation between TPH2 gene rs7305115 SNP,interrelated environmental factors and the rate of attempted suicide. Controls were paired with cases according to the same gender, similar age (no more than 3 years) and from the same district.
  
  
  RESULTS
  There were remarkably significant differences in gene types and gene frequency between case and control groups (P < 0.001). Data from multivariate conditional logistic regression model analysis showed that hopelessness, negative life-events and family history of suicide were relationship of attempted suicide in patients with major depression with OR values as 0.33 (95% CI: 0.22-0.99), 7.68 (95% CI: 5.79-13.74), 6.64 (95% CI: 2.48-11.04), 2.98 (95% CI: 1.17-5.04) respectively. There was no first level interaction between any of the two risk factors.
  
  
  CONCLUSIONS
  Results from the study supported the idea that hopelessness, negative life-events and family history of suicide were risk factors of attempted suicide in major deprbssion while TPH2 gene rs7305115 A/A might be the protective factor.
authors.affiliation: Wuxi Mental Health Center, Nanjing Medical College, Wuxi 214151, China.
authors.forename: Yu-qi
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Guo-zhen
authors.initials: GZ
authors.lastname: Yuan
authors.forename: Gui-lin
authors.initials: GL
authors.lastname: Li
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Yao
authors.forename: Zao-huo
authors.initials: ZH
authors.lastname: Cheng
authors.forename: Xing
authors.initials: X
authors.lastname: Chu
authors.forename: Chao-jun
authors.initials: CJ
authors.lastname: Liu
authors.forename: Qing-hai
authors.initials: QH
authors.lastname: Liu
authors.forename: Ai-rong
authors.initials: AR
authors.lastname: Wang
authors.forename: Gui-zhi
authors.initials: GZ
authors.lastname: Shi
authors.forename: Bao-heng
authors.initials: BH
authors.lastname: Wang
authors.forename: Yi-ren
authors.initials: YR
authors.lastname: Cheng
authors.forename: Ming-lian
authors.initials: ML
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Li
mesh_terms: D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003865:Major Depressive Disorder / Q000235:genetics / Q000523:psychology*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013406:Suicide, Attempted / Q000523:psychology* / Q000706:statistics & numerical data*; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase