title: Triplet pregnancy after metformin in a woman with polycystic ovary syndrome.
abstract: OBJECTIVE
  To report a case of triplet pregnancy after metformin treatment only, in a woman with polycystic ovary syndrome (PCOS) and a family history of twin pregnancies.
  
  
  METHODS
  Case report and literature review.
  
  
  METHODS
  Gynecologic endocrinology clinic, tertiary federal hospital.
  
  
  METHODS
  A white, lean, 34-year-old woman, treated for PCOS since age 28, who had tried to conceive spontaneously for 6 months, with no evidence of ovulation.
  
  
  METHODS
  Metformin, 850 mg, for 1.5 months.
  
  
  METHODS
  Pregnancy (triplet).
  
  
  RESULTS
  Pregnancy developed up to premature labor at 31 weeks. The patient delivered two boys and one girl, in need of neonatal intensive care for 33 to 44 days.
  
  
  CONCLUSIONS
  Despite the paucity of literature data, we believe that metformin, when associated with predisposing therapies or conditions, may facilitate high-order pregnancies.
authors.affiliation: Gynecological Endocrinology Sector, Internal Medicine Service, Hospital da Lagoa, Health Ministry, Rio de Janeiro, Brazil. Electronic address: rclapauch@uol.com.br.
authors.forename: Ruth
authors.initials: R
authors.lastname: Clapauch
authors.affiliation: Gynecological Endocrinology Sector, Internal Medicine Service, Hospital da Lagoa, Health Ministry, Rio de Janeiro, Brazil.
authors.forename: Tatiana M
authors.initials: TM
authors.lastname: Mattos
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007247:Infertility, Female / Q000209:etiology; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D016896:Treatment Outcome; D014310:Triplets
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin