title: [An experimental model of pulmonary valve implantation: a percutaneous and transventricular approach without cardiopulmonary bypass].
abstract: Pulmonary valve replacement by a catheter procedure remains a therapeutic challenge. In this report, the authors demonstrate the possibility of implantation of a porcine xenograft specially prepared on an auto-expanding stent (valved stent) in a sheep model. The porcine xenograft was prepared with hypotonic non-enzymatic solutions. It was sewn onto an auto-expanding stent (Luminex Bard) and inserted into an introduction sheath of 22-24 F (Gore) calibre. In a preliminary approach, the catheter was inserted through the jugular vein. Out of 6 attempts, it was possible to position the valved stent in the pulmonary position in two cases but all the animals died of different causes: tamponade, arrhythmias, air embolism. Following this experience, two valves were implanted through the superior and inferior vena cavae. This first percutaneous approach has been modified to a mixed medico-surgical approach with a transventricular introduction without cardiopulmonary bypass. This was performed through a left thoracotomy with puncture of the pulmonary infundibulum using the same systems of introduction and valved stent. Three implantations were successfully performed. In addition, a reduction of the size of the pulmonary artery was realised to prevent embolisation of the valved stent to the pulmonary artery or one of its branches. The transventricular approach is feasible for implantation of pulmonary valve prosthesis on a stent. This technique could be adapted for correction of pulmonary regurgitation after correction of Tetralogy of Fallot associated with reduction of the pulmonary infundibulum.
authors.affiliation: Service des maladies cardiovasculaires infantiles et congénitales, Hôpital Cardiologique, CHRU de Lille, 59037 Lille cedex. f-godart@chru-lille.fr
authors.forename: F
authors.initials: F
authors.lastname: Godart
authors.forename: A
authors.initials: A
authors.lastname: Vincentelli
authors.forename: I
authors.initials: I
authors.lastname: Bouzguenda
authors.forename: F
authors.initials: F
authors.lastname: Juthier
authors.forename: F
authors.initials: F
authors.lastname: Wautot
authors.forename: F
authors.initials: F
authors.lastname: Mouquet
authors.forename: A
authors.initials: A
authors.lastname: Prat
authors.forename: C
authors.initials: C
authors.lastname: Rey
authors.forename: D
authors.initials: D
authors.lastname: Corseaux
authors.forename: A
authors.initials: A
authors.lastname: Ung
authors.forename: B
authors.initials: B
authors.lastname: Jude
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D006328:Cardiac Catheterization; D002315:Cardiopulmonary Bypass; D002423:Cause of Death; D004617:Embolism / Q000517:prevention & control; D005240:Feasibility Studies; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006352:Heart Ventricles; D007601:Jugular Veins; D011651:Pulmonary Artery / Q000473:pathology / Q000601:surgery; D011664:Pulmonary Valve / Q000601:surgery*; D011677:Punctures; D012756:Sheep; D015607:Stents; D013908:Thoracotomy; D014684:Venae Cavae