Immediate-early gene product ICP22 inhibits the trans-transcription activating function of P53-mdm-2.
As a product of HSVI immediate-early gene, ICP22 is capable of interacting with various cellular transcriptive and regulatory molecules during viral infection so as to impact the normal cellular molecular mechanism. ICP22 expressed in transfected cells can push the cells' entering into S phase with binding to mdm-1 promoter region and impact its trans-transcription activating effect by P53. Consequently, the MDM-2 binds to P53, and the degradation effects by the ubiquitous pathway are decreased, improving indirectly the P53 levels in cells and making the cells progress into the S phase.
Guo
HongXiong
H
Department of Viral Immunology, Institute of Medical Biology, CAMS and PUMC, Kunming 650118, China.
Cun
Wei
W
Liu
LongDing
L
Wang
LiChun
L
Zhao
HongLing
H
Dong
ChengHong
C
Li
QiHan
Q
D000818:Animals; D001483:Base Sequence; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D017931:DNA Primers / Q000235:genetics; D017781:Genes, Immediate-Early; D018259:Herpesvirus 1, Human / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics* / Q000378:metabolism; D066298:In Vitro Techniques; D011401:Promoter Regions, Genetic; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation; D014162:Transfection; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*; D020798:Two-Hybrid System Techniques; D054334:Viral Regulatory and Accessory Proteins
D017931:DNA Primers; C057294:ICP22 protein, human herpesvirus 1; D017874:Immediate-Early Proteins; D011994:Recombinant Proteins; D016159:Tumor Suppressor Protein p53; D054334:Viral Regulatory and Accessory Proteins; D051736:Proto-Oncogene Proteins c-mdm2