title: Optimized synthesis of aminooxy-peptides as glycoprobe precursors for surface-based sugar-protein interaction studies.
abstract: An improved procedure for solid phase coupling of Boc-aminooxyacetic acid to peptides is described. By avoiding base-containing activation mixtures which cause over-acylation, it practically suppresses this unwanted side reaction and leads to near quantitative yields of Aoa-peptides, useful as glycoprobe precursors in glycomic studies.
authors.affiliation: Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park, Dr. Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Jiménez-Castells
authors.forename: Beatriz G
authors.initials: BG
authors.lastname: de la Torre
authors.forename: Ricardo
authors.initials: R
authors.lastname: Gutiérrez Gallego
authors.forename: David
authors.initials: D
authors.lastname: Andreu
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D015335:Molecular Probes; D010455:Peptides / Q000138:chemical synthesis*; D011506:Proteins / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D002241:Carbohydrates; D015335:Molecular Probes; D010455:Peptides; D011506:Proteins