[Roles of microRNAs in hematopoietic cell differentiation and the related tumors].
MicroRNAs (miRNAs) are a family of 21-25 nucleotide small nonprotein-coding RNAs. They regulate gene expression at post-transcriptional level by mRNA degradation or translation repression. Hematopoiesis is one of the most important highly regulated multistage process, which includes orderly turn-on and turn-off of many genes; any wrong modulation may result in blood diseases. Several miRNAs have been found to be involved in hematopoiesis and hematopoietic tumor genesis.
Yang
Gui-hua
GH
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.
Wang
Fang
F
Zhang
Jun-wu
JW
D001773:Blood Cells / Q000502:physiology*; D002454:Cell Differentiation; D019337:Hematologic Neoplasms / Q000473:pathology*; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*
D035683:MicroRNAs