An investigation of hormone and lipid associations after weight loss in women.
OBJECTIVE
The objectives of this study were to determine 1) whether the extent of weight loss is predictive of the degree of changes in hormone and lipid levels; 2) the interactions between energy regulating hormones after weight loss through an energy deficit/exercise protocol diet and exercise; 3) whether initial metabolic parameters are indicative of the extent of weight loss.


METHODS
Thirty-five hyperlipidemic females (BMI 28-39 kg/m2) 35-60 years old participated in a six month weight loss trial. Weight loss resulted from a diet and exercise program that when combined produced a 30% energy deficit. Fasting plasma taken during 2 wk stabilization periods at the beginning and end of the study was analysed for lipids, hormone and glucose levels.


RESULTS
Average weight loss was 11.7 +/- 2.5 kg (p < 0.0001). TC, LDL-C, and triacylglycerols decreased 9.3 +/- 9.5% (p < 0.0001), 7.4 +/- 12.2% (p < 0.001), and 26.8 +/- 19.6% (p < 0.05), respectively, while HDL-C increased (p < 0.05) by 8.2 +/- 16.3%. Leptin levels declined (p < 0.001) 48.9 +/- 16.0% and ghrelin levels rose (p < 0.001) 21.2 +/- 26.7%. While overall levels of adiponectin did not differ, individual values changed such that weight loss predicted increases in adiponectin levels. Though initial weight did not predict weight loss, baseline lipid and insulin levels positively predicted weight loss.


CONCLUSIONS
Initial metabolic parameters may be predictors of weight loss. Beneficial effects of weight loss as achieved through diet and exercise on measured parameters indicate moderate weight loss reduces key risk factors of cardiovascular disease in overweight individuals.
Santosa
Sylvia
S
School of Dietetics and Human Nutrition, McGill University, Montreal, Canada.
Demonty
Isabelle
I
Lichtenstein
Alice H
AH
Cianflone
Katherine
K
Jones
Peter J H
PJ
D052242:Adiponectin / Q000097:blood; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control*; D003131:Combined Modality Therapy; D004038:Diet, Reducing; D004734:Energy Metabolism; D015444:Exercise / Q000502:physiology*; D005260:Female; D054439:Ghrelin; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000628:therapy*; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000628:therapy*; D036361:Peptide Hormones / Q000097:blood; D011237:Predictive Value of Tests; D012307:Risk Factors; D015431:Weight Loss / Q000502:physiology*
D052242:Adiponectin; D001786:Blood Glucose; D054439:Ghrelin; D020738:Leptin; D008055:Lipids; D036361:Peptide Hormones