title: Modulation of the endocrine and immune systems by well-controlled hyperthermia equipment.
abstract: Since high levels of hyperthermia induce immunosuppression to a certain extent (i.e., granulocytosis and lymphocytopenia) in patients, we applied mild hyperthermia in volunteers using equipment enabling well-controlled hyperthermia. Restricted control of rectal temperature at 39.4 (+/- 0.2) degrees C for 30 min was conducted and various parameters of the body were examined. The most prominent change observed during exposure to hyperthermia was elevated levels of pH and PO(2) in the blood, even in the venous blood. A transient elevation of ACTH, cortisol and growth hormone in the blood was also seen during this time. In parallel with this phenomenon, the number of total lymphocytes and those of its subsets (especially CD57(+) or CD56(+) NK cells and NKT cells) increased. More interestingly, the proportion of HLA-DR (MHC class II antigens) increased in NK and NKT cells, and their intensity on the surface of CD20(+) B cells increased. These results suggest that mild hyperthermia is important for modulation of the functions of the circulatory, endocrine and immune systems.
authors.affiliation: Department of Immunology, Niigata University School of Medicine, Niigata, Japan.
authors.forename: Chikako
authors.initials: C
authors.lastname: Tomiyama-Miyaji
authors.forename: Mayumi
authors.initials: M
authors.lastname: Watanabe
authors.forename: Takahiko
authors.initials: T
authors.lastname: Ohishi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kanda
authors.forename: Eisuke
authors.initials: E
authors.lastname: Kainuma
authors.forename: Hanaa Y
authors.initials: HY
authors.lastname: Bakir
authors.forename: Jiwei
authors.initials: J
authors.lastname: Shen
authors.forename: Hongwei
authors.initials: H
authors.lastname: Ren
authors.forename: Masashi
authors.initials: M
authors.lastname: Inoue
authors.forename: Keiho
authors.initials: K
authors.lastname: Tajima
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Bai
authors.forename: Toru
authors.initials: T
authors.lastname: Abo
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D001775:Blood Circulation / Q000276:immunology; D001831:Body Temperature / Q000276:immunology; D002478:Cells, Cultured; D005334:Fever / Q000097:blood / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D013006:Growth Hormone / Q000097:blood; D006681:HLA-D Antigens / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D018655:Lymphocyte Count; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism
chemical_list: D006681:HLA-D Antigens; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D006854:Hydrocortisone