title: Morphometric and microscopic evaluation of the effect of a solution of alendronate as an intracanal therapeutic agent in rat teeth submitted to late reimplantation.
abstract: The use of substances that inhibit root resorption may be an alternative for cases of unsuccessful reimplants. Hence, the purpose of this study was to test a solution of alendronate, a resorption inhibitor, as an intracanal therapeutic agent for teeth submitted to late reimplantation. Thirty rat maxillary right central incisors were avulsed and kept dry for 30 min. The teeth were instrumented, and the root surfaces treated with 1% hypochlorite solution followed by application of 2% sodium fluoride. Thereafter, the teeth were divided in two groups according to the intracanal dressing: (i) group I, solution of alendronate and (ii) group II, calcium hydroxide paste. Teeth were then reimplanted in their respective sockets. The animals were killed at 15, 30 and 60 days after reimplantation and the samples processed for morphometric and microscopic analysis. The results demonstrated that the solution of alendronate and the calcium hydroxide paste limited the root resorption, yet did not impair its occurrence. It may be concluded that alendronate and calcium hydroxide paste demonstrated similar behavior.
authors.affiliation: Integrate Clinic, Dentistry School of Adamantina, São Paulo, Brazil. grazielagm@uol.com.br
authors.forename: Graziela Garrido
authors.initials: GG
authors.lastname: Mori
authors.forename: Roberto Brandão
authors.initials: RB
authors.lastname: Garcia
authors.forename: Ivaldo
authors.initials: I
authors.lastname: Gomes de Moraes
authors.forename: Clóvis Monteiro
authors.initials: CM
authors.lastname: Bramante
authors.forename: Norberti
authors.initials: N
authors.lastname: Bernardineli
mesh_terms: D019386:Alendronate / Q000627:therapeutic use*; D000818:Animals; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002126:Calcium Hydroxide / Q000627:therapeutic use; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012388:Root Canal Irrigants / Q000627:therapeutic use*; D012391:Root Resorption / Q000517:prevention & control*; D018709:Statistics, Nonparametric; D014084:Tooth Avulsion / Q000628:therapy*; D014090:Tooth Replantation; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D012388:Root Canal Irrigants; D002126:Calcium Hydroxide; D019386:Alendronate