title: Topoisomerase-II-inhibitory principles from the stems of Spatholobus suberectus.
abstract: Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (= (+)-catechin-(4-->8)-(-)-epicatechin) (1) and (+)-catechin-(4-->8)-(+)-catechin-(4-->8)-(-)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC50 values of 22.5+/-2.3 and 21.9+/-2.2 nM, resp.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
authors.forename: Ah-Reum
authors.initials: AR
authors.lastname: Han
authors.forename: Hyen Joo
authors.initials: HJ
authors.lastname: Park
authors.forename: Daofeng
authors.initials: D
authors.lastname: Chen
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Jang
authors.forename: Hwa-Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Eun-Kyoung
authors.initials: EK
authors.lastname: Seo
mesh_terms: D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007887:Fabaceae / Q000201:enzymology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems / Q000201:enzymology*; D059005:Topoisomerase II Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D010936:Plant Extracts; D059005:Topoisomerase II Inhibitors; D004250:DNA Topoisomerases, Type II