title: [Effect of Xianlong granules on immunological function in rats of adjuvant arthritis].
abstract: OBJECTIVE
  To study the effect of Xianlong granules (XLG) on immunological function in the rat of adjuvant arthritis (AA).
  
  
  METHODS
  Rats were randomly divided into normal group, AA model group, prednisone group and low, middle and high dose XLG groups, 10 rats in each group. All rats were treated by intragastric administration from the 18 days after arthritis was induced by the complete Freud's adjuvant and the effect of XLG on toes swelling was observed. On the 30th days after modeling, proliferation of the splenic and thymic lymphocytes, and IgG secreted by splenocytes were detected respectively by MTT assay and ELISA.
  
  
  RESULTS
  Compared with the model group, both the high and middle dose XLG groups had significant therapeutic effects on toes dwelling in the rat of AA (P < 0.05 or P < 0.01); The low, middle and high dose XLG groups strengthened the PHAM-inhibited proliferation of splenic lymphocytes (P < 0.05), and inhibited the PHAM-augmented proliferation of thymic lymphocytes (P < 0.05); XLG did not significantly effect on IgG level secreted by splenocytes in rats of AA.
  
  
  CONCLUSIONS
  XLG can cure toes swelling in rats of AA, which is related with regulation of the abnormal immunlological function.
authors.affiliation: Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Wei-Zhuo
authors.initials: WZ
authors.lastname: Wang
authors.forename: Xiong
authors.initials: X
authors.lastname: Guo
authors.forename: Jun-Chang
authors.initials: JC
authors.lastname: Chen
authors.forename: Pu-Wei
authors.initials: PW
authors.lastname: Yuan
authors.forename: Yi-Heng
authors.initials: YH
authors.lastname: Liu
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Li
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D049109:Cell Proliferation / Q000187:drug effects; D017812:Colubridae; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004487:Edema / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D005260:Female; D007074:Immunoglobulin G / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D008516:Medicine, Chinese Traditional; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D014034:Toes / Q000473:pathology
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007074:Immunoglobulin G; D008419:Materia Medica