N-Acetylcysteine in the prevention of ototoxicity.
Prevention of ototoxicity after the administration of aminoglycoside antibiotics has been notably difficult, in particular in patients with chronic kidney disease. Feldman et al. report that oral administration of 600 mg N-acetylcysteine twice daily significantly ameliorates gentamicin-induced ototoxicity in hemodialysis patients. That approach may help to prevent aminoglycoside-induced hearing loss in these high-risk patients in daily practice.
Tepel
M
M
Charité Campus Benjamin Franklin, Medizinische Klinik IV, Nephrologie, Berlin, Germany. Martin.Tepel@charite.de
D000111:Acetylcysteine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000284:Administration, Oral; D000617:Aminoglycosides / Q000009:adverse effects / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016470:Bacteremia / Q000517:prevention & control; D005839:Gentamicins / Q000009:adverse effects / Q000627:therapeutic use; D034381:Hearing Loss / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D005839:Gentamicins; D000111:Acetylcysteine