Asthma is associated with increased mortality in individuals with sickle cell anemia.
An analysis of a prospective cohort of individuals with sickle cell anemia (SCA), enrolled from birth through adulthood, was conducted to determine if asthma is a risk factor for death in SCA. All-cause mortality was determined for participants after adjusting for known risk factors for death in SCA. The study included 1,963 individuals who were followed for 18,495 patient-years. After controlling for established risk factors, individuals with SCA and asthma had a more than two-fold higher risk of mortality (hazard ratio 2.36, 95% CI 1.21 to 4.62, p=0.01). To summarize, asthma is a risk factor for death in SCA.
Boyd
Jessica H
JH
Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St. Louis, MO 63108, USA.
Macklin
Eric A
EA
Strunk
Robert C
RC
DeBaun
Michael R
MR
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D000755:Anemia, Sickle Cell / Q000150:complications / Q000401:mortality*; D001249:Asthma / Q000150:complications* / Q000453:epidemiology; D002423:Cause of Death; D002637:Chest Pain / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000453:epidemiology; D012307:Risk Factors; D012640:Seizures / Q000453:epidemiology; D016019:Survival Analysis