title: [Perioperative heart rate in patients taking beta-blockers: reality and efficiency of the treatment].
abstract: OBJECTIVE
  To compare perioperative heart rate (HR) control of patients chronically exposed to beta-blockers (BB) with those of patients whom BB treatment was initiated one week preoperatively.
  
  
  METHODS
  HR was noticed at three successive time periods: the anaesthesia visit, just before induction of anaesthesia, and during surgery (maximum and minimum HR). HR, presented as mean+/-SD, was compared among 3 groups of patients: BB chronic treatment, preoperative BB, and a control group not taking BB.
  
  
  RESULTS
  Four hundred (and) six patients were included: 181 chronic BB patients, 20 preoperative BB, and 205 control patients. As compared to the control group, HR of chronic BB patients were lower (P<0.05) than those of the control group at the three time period of the study. In the preoperative BB patient group, one week BB treatment resulted in a mean 30% reduction of HR. Just before induction of anaesthesia, HR of preoperative BB patients was lower than that of chronic BB patients (55+/-11 vs 67+/-13 b/min; P<0.05).
  
  
  CONCLUSIONS
  Beta-blockers treatment initiated one week before surgery could be more effective on perioperative HR control than chronic BB treatment.
authors.affiliation: Service d'anesthésie-réanimation 1, centre hospitalier Lyon-Sud, Pierre-Benite cedex, France.
authors.forename: N
authors.initials: N
authors.lastname: Danton
authors.forename: C
authors.initials: C
authors.lastname: Ferretti
authors.forename: M
authors.initials: M
authors.lastname: Benoist
authors.forename: J
authors.initials: J
authors.lastname: Crozon
authors.forename: T
authors.initials: T
authors.lastname: Rimmelle
authors.forename: P-Y
authors.initials: PY
authors.lastname: Gueugniaud
authors.forename: V
authors.initials: V
authors.lastname: Piriou
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D006331:Heart Diseases / Q000517:prevention & control*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007432:Intraoperative Period; D011300:Preoperative Care; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists