title: Combined laparoscopic and radical vaginal treatment of primary vaginal leiomyosarcoma in a patient with unicornuate uterus and pelvic kidney.
abstract: We report a case of primary vaginal leiomyosarcoma occurring in a patient with a unicornuate uterus and pelvic kidney. The patient was treated with radical partial vaginectomy, unilateral groin dissection, total laparoscopic hysterectomy, and left pelvic laparoscopic lymphadenectomy, followed by adjuvant chemotherapy. Twenty-five months after her original procedure, the patient is alive and free of disease. The exact association between müllerian anomalies and primary malignancies of the genitourinary tract is unclear. It is nonetheless important to be aware of the close embryonic association between the genital and urinary tracts when evaluating such patients and choosing the appropriate surgical and therapeutic approach.
authors.affiliation: Division of Gynecologic Oncology and Minimally Invasive Surgery, Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, New York 10029, USA.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Zakashansky
authors.forename: Michele
authors.initials: M
authors.lastname: Peiretti
authors.forename: Ali
authors.initials: A
authors.lastname: Mahdavi
authors.forename: Jin K
authors.initials: JK
authors.lastname: Chun
authors.forename: Farr
authors.initials: F
authors.lastname: Nezhat
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D007668:Kidney / Q000002:abnormalities; D010535:Laparoscopy; D007890:Leiomyosarcoma / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D008197:Lymph Node Excision; D016896:Treatment Outcome; D014564:Urogenital Abnormalities / Q000150:complications; D014599:Uterus / Q000002:abnormalities; D014625:Vaginal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000601:surgery*
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D004317:Doxorubicin