title: BK virus-induced tubulointerstitial nephritis in a child with acute lymphoblastic leukemia.
abstract: We report a case of BK virus-induced tubulointerstitial nephritis in a child with acute lymphoblastic leukemia. Primary BK virus infection was exacerbated by chemotherapy-induced immunodeficiency. Careful administration of chemotherapy and anti-viral therapy prevented further damage. This diagnosis should be considered in children who experience renal dysfunction during cancer treatment.
authors.affiliation: Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. hiroto.inaba@stjude.org
authors.forename: Hiroto
authors.initials: H
authors.lastname: Inaba
authors.forename: Deborah P
authors.initials: DP
authors.lastname: Jones
authors.forename: Lillian W
authors.initials: LW
authors.lastname: Gaber
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Shenep
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Call
authors.forename: Ching-Hon
authors.initials: CH
authors.lastname: Pui
authors.forename: Bassem I
authors.initials: BI
authors.lastname: Razzouk
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001739:BK Virus / Q000302:isolation & purification*; D001707:Biopsy, Needle; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007677:Kidney Function Tests; D009395:Nephritis, Interstitial / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D027601:Polyomavirus Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D018570:Risk Assessment; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy
chemical_list: D000998:Antiviral Agents