title: Scaffold composition and biological relevance of screening libraries.
abstract: The chemical scaffolds from which screening libraries are built have strong influence on the libraries' utility for screening campaigns. Here we present analysis of the scaffold composition of several types of commercially available screening collections and compare those compositions to those of drugs and drug candidates.
authors.affiliation: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38103, USA.
authors.forename: Anang A
authors.initials: AA
authors.lastname: Shelat
authors.forename: R Kiplin
authors.initials: RK
authors.lastname: Guy
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation* / Q000379:methods*; D008024:Ligands; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D019151:Peptide Library; D010641:Phenotype; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D008024:Ligands; D019151:Peptide Library