Assessment of cancer immunotherapy outcome in terms of the immune response time features.
A cytokine-based periodic immunotherapy treatment is included in a model of tumour growth with a delay. The effects of dose schedule are studied in the case of a weak immune system and a growing tumour. We find the existence of 'metastable' states (that may last for tens of years) induced by the treatment and also potentially adverse effects of the dosage frequency on the stabilization of the tumour. These two effects depend on the delay between the tumour growth and the immune system response, the cytokine dose burden, and other parameters considered in the model.
Rodríguez-Pérez
D
D
Departamento de Física Matemática y de Fluidos, UNED, PO Box 60141, 28080 Madrid, Spain. daniel@dfmf.uned.es
Sotolongo-Grau
Oscar
O
Espinosa Riquelme
Ramón
R
Sotolongo-Costa
Oscar
O
Santos Miranda
J Antonio
JA
Antoranz
J C
JC
D000465:Algorithms; D007107:Immune System / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology; D007167:Immunotherapy; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome