Immune system recognition of Trypanosoma cruzi.
Innate and adaptive cellular immune recognition is crucial for control of the protozoan parasite Trypanosoma cruzi. T. cruzi triggers both MyD88-dependent and TRIF-dependent innate activation pathways in macrophages and dendritic cells. TLR-2 and TLR-9 recognize GPI anchors and parasite DNA, respectively; however other, as yet undefined receptors and ligands, also appear to be involved in innate recognition. CD8(+) T cells distinguish T. cruzi-infected host cells primarily via robust recognition of MHC-associated peptide epitopes from the large and highly diverse trans-sialidase family of surface proteins. To date there has been minimal investigation of linkages between innate immune recognition in vivo and the generation of adaptive cellular immune responses.
Tarleton
Rick L
RL
Center for Tropical & Emerging Global Diseases and Department of Cellular Biology, Coverdell Center for Biomedical Research, 500 D.W. Brooks Drive, University of Georgia, Athens, GA 30602, USA. tarleton@cb.uga.edu
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D014355:Chagas Disease / Q000276:immunology* / Q000469:parasitology; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D015800:Protozoan Proteins / Q000276:immunology / Q000378:metabolism*; D016052:Protozoan Vaccines / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism*; D014349:Trypanosoma cruzi / Q000276:immunology* / Q000378:metabolism
D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D051193:Toll-Like Receptors