[Effect of Fuzheng Peiben therapy on dendritic cell in patients with breast cancer].
OBJECTIVE
To investigate the repairing mechanism of Fuzheng Peiben Therapy on cellular immunofunction in patients with breast cancer on cellar and molecular level.


METHODS
The tumor tissue and axillary lymph node samples were evaluated with the flow cytometry for CD83, CD80, CD86 before and after neoadujvant therapy.


RESULTS
The levels of CD83, CD80, CD86 were singificantly decreased in group A (treated with surgery only), B (treated with neoadujvant chemotherapy plus surgery) and C (treated with neoadujvant chemotherapy plus surgery with shenqi Fuzheng Injection) compared with that in normal team (P < 0.05 or 0.01); The levels of CD83, CD80, CD86 were significantly decreased in group A, B and C compared between before and after neoadujvant chemotherapy (P < 0.05 or 0.01); They were not significantly decreased between group A and group C (P > 0.05).


CONCLUSIONS
The cellular immunity was inpaired considerably by neoadujvant chemotherapy. Neoadjuvant chemotherapy combined with Shenqi Fuzheng Injection can enhance the cellular immunity considerably.
Li
Hong-sheng
HS
Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Fang
Chi-hua
CH
Wang
Yuan-dong
YD
Su
Xu-chun
XC
Yang
Bo
B
Qi
Yan-chao
YC
Liu
Cheng-lin
CL
Lu
Min-ying
MY
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000276:immunology; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; C521737:shenqi fuzheng