[A case-control study on the risk factors for attempted suicide in patients with major depression].
OBJECTIVE
To understand the environmental risk factors on attempted suicide in patients with major depression, and to study the interaction between factors as single nucleotide polymorphism(SNP) of TPH2 gene rs7305115 associated to attempted suicide in major depression.


METHODS
Paired case-control study on 215 suicide attempters with major depression (92 male, 123 female) and molecular biological techniques were used to study the relation between TPH2 gene rs7305115 SNP,interrelated environmental factors and the rate of attempted suicide. Controls were paired with cases according to the same gender, similar age (no more than 3 years) and from the same district.


RESULTS
There were remarkably significant differences in gene types and gene frequency between case and control groups (P < 0.001). Data from multivariate conditional logistic regression model analysis showed that hopelessness, negative life-events and family history of suicide were relationship of attempted suicide in patients with major depression with OR values as 0.33 (95% CI: 0.22-0.99), 7.68 (95% CI: 5.79-13.74), 6.64 (95% CI: 2.48-11.04), 2.98 (95% CI: 1.17-5.04) respectively. There was no first level interaction between any of the two risk factors.


CONCLUSIONS
Results from the study supported the idea that hopelessness, negative life-events and family history of suicide were risk factors of attempted suicide in major deprbssion while TPH2 gene rs7305115 A/A might be the protective factor.
Zhang
Yu-qi
YQ
Wuxi Mental Health Center, Nanjing Medical College, Wuxi 214151, China.
Yuan
Guo-zhen
GZ
Li
Gui-lin
GL
Yao
Jian-jun
JJ
Cheng
Zao-huo
ZH
Chu
Xing
X
Liu
Chao-jun
CJ
Liu
Qing-hai
QH
Wang
Ai-rong
AR
Shi
Gui-zhi
GZ
Wang
Bao-heng
BH
Cheng
Yi-ren
YR
Zhang
Ming-lian
ML
Li
Ke
K
D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003865:Major Depressive Disorder / Q000235:genetics / Q000523:psychology*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013406:Suicide, Attempted / Q000523:psychology* / Q000706:statistics & numerical data*; D014365:Tryptophan Hydroxylase / Q000235:genetics*
C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase