title: [The relationship between high-sensitivity C-reactive protein and peripheral artery disease].
abstract: OBJECTIVE
  To investigate the association between high-sensitivity C-reactive protein and peripheral arterial disease.
  
  
  METHODS
  The study population comprised 643 subjects aged at least 40 years in whom both CRP and ankle-brachial index were measured. The survey included information on demographic characteristics, clinical examinations and ankle-brachial index (ABI). Ankle-brachial index (ABI) < 0.9 was diagnostic of PAD.
  
  
  RESULTS
  64 subjects (10%) were diagnosed as PAD. The prevalence of current smoking, hypertension, diabetes, low HDL cholesterol and history of cardiovascular disease in the participants with PAD were higher than without (P < 0.05). The prevalence of hypertension, diabetes, and history of cardiovascular disease was higher in subjects with high CRP (P < 0.05). In logistic regression analyses, the moderate CRP group and high CRP group had a two-fold higher OR compared with the low CRP group. The P-trend across CRP groups was statistically significant (P = 0.036). High log-transformed hs-CRP level was significantly related to PAD after adjustment for the cardiovascular risk factors mentioned above (P = 0.007).
  
  
  CONCLUSIONS
  hs-CRP is related to PAD and high level hs-CRP is an independent risk factor for PAD in Chinese adults aged 40 years and more.
authors.affiliation: Department of Preventive Medicine, Medical College, Tongji University, Shanghai 200092, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Yu
authors.forename: Jue
authors.initials: J
authors.lastname: Li
authors.forename: Ju-Long
authors.initials: JL
authors.lastname: Tian
authors.forename: Ru-Lin
authors.initials: RL
authors.lastname: Zhang
authors.forename: Si-Fang
authors.initials: SF
authors.lastname: Cui
authors.forename: Qi-Guang
authors.initials: QG
authors.lastname: Tong
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Zheng
authors.forename: Ying-Yi
authors.initials: YY
authors.lastname: Luo
authors.forename: Xian-Kai
authors.initials: XK
authors.lastname: Li
authors.forename: Da-Yi
authors.initials: DY
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000453:epidemiology*; D002097:C-Reactive Protein / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000453:epidemiology*; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein