End-stage renal failure in adolescence with Sjögren's syndrome autoantibodies SSA and SSB.
We describe two adolescents who presented with end-stage renal failure and clinical features suggestive of Sjögren's syndrome (SS). They both demonstrated severe, chronic, tubulointerstitial inflammation on renal biopsy, high-titre antinuclear antibodies, high immunoglobulin A and G concentrations, positive anti-SSA and anti-SSB antibodies, and negative anti-double-stranded DNA antibodies. One had subjective and objective evidence of the sicca complex (dry eyes and/or dry mouth) and fulfilled the commonly accepted SS consensus criteria. The other showed no evidence of the sicca complex but fulfilled modified criteria for juvenile SS. SS may be underrecognised as a cause of end-stage renal failure in childhood.
Johnson
Sally
S
Department of Nephrology, Birmingham Children's Hospital, Birmingham, B4 6NH, UK. s.a.johnson.2@bham.ac.uk
Hulton
Sally-Anne
SA
Brundler
Marie-Anne
MA
Moss
Celia
C
Huissoon
Aarnoud
A
Taylor
C Mark
CM
D000293:Adolescent; D000419:Albuminuria; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D003404:Creatinine / Q000097:blood; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000276:immunology*; D008297:Male; D012859:Sjogren's Syndrome / Q000097:blood / Q000276:immunology*; D014508:Urea / Q000097:blood
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006454:Hemoglobins; D014508:Urea; D002097:C-Reactive Protein; D003404:Creatinine