A chelation-assisted transformation: synthesis of maleimides by the Rh-catalyzed carbonylation of alkynes with pyridin-2-ylmethylamine.
The reaction of alkynes 1 with CO and pyridin-2-ylmethylamine (2) in the presence of Rh4(CO)12/P(OEt)3 results in the incorporation of two molecules of CO leading to maleimide derivatives 3. The coordination of the pyridine nitrogen in 2 to a rhodium center is essential for the reaction to proceed.
Inoue
Satoshi
S
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Fukumoto
Yoshiya
Y
Chatani
Naoto
N