Synthesis of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues and their activity against phospholipase A2.
A variety of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues were synthesized. 2-oxoamides containing a tetrazole, a thioethyl or a thioacetyl group are weak inhibitors of GIVA cPLA(2), while derivatives containing a methyl tetrazole, a diethyl phosphonate or a thioethyl group are weak inhibitors of GV sPLA(2).
Moutevelis-Minakakis
Panagiota
P
Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece.
Neokosmidi
Afroditi
A
Filippakou
Maria
M
Stephens
Daren
D
Dennis
Edward A
EA
Kokotos
George
G
D000577:Amides / Q000138:chemical synthesis*; D021542:Amino Acids, Neutral / Q000737:chemistry*; D010169:Palmitic Acids / Q000737:chemistry; D064801:Phospholipase A2 Inhibitors; D054467:Phospholipases A2 / Q000378:metabolism; D014631:Valerates / Q000737:chemistry; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000737:chemistry*
D000577:Amides; D021542:Amino Acids, Neutral; D010169:Palmitic Acids; D064801:Phospholipase A2 Inhibitors; D014631:Valerates; D005680:gamma-Aminobutyric Acid; C013809:5-aminovaleric acid; C024707:2-hydroxyhexadecanoic acid; D054467:Phospholipases A2