title: Venous ulcers of the lower limbs due to congenital thalidomide-related valve defect.
abstract: A 44-year-old woman with fetal thalidomide syndrome and congenital pseudoainhum of the left big toe had a 5-year history of painful nonhealing ulcers in the left malleolar region. Venous Doppler ultrasonography showed hypoagenesis of the valve flaps of the deep and superficial venous circuit. To our knowledge, this is the first description of congenital pseudoainhum associated with fetal thalidomide syndrome. The coexistence of cutaneous ulcers in our case might be coincidental but may be related to a congenital valve defect (hypoagenesis) caused by thalidomide.
authors.affiliation: Section of Dermatology, Department of Clinical Medicine and Immunological Sciences, University of Siena, Siena, Italy. rubegni@unisi.it
authors.forename: Pietro
authors.initials: P
authors.lastname: Rubegni
authors.forename: Sara
authors.initials: S
authors.lastname: Poggiali
authors.forename: Roberta
authors.initials: R
authors.lastname: Bilenchi
authors.forename: Agnese
authors.initials: A
authors.lastname: Diana
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Risulo
authors.forename: Letizia
authors.initials: L
authors.lastname: Civeli
authors.forename: Michele
authors.initials: M
authors.lastname: Fimiani
mesh_terms: D000328:Adult; D005260:Female; D006349:Heart Valve Diseases / Q000139:chemically induced / Q000150:complications / Q000151:congenital; D006801:Humans; D018811:Maternal Exposure / Q000009:adverse effects*; D013723:Teratogens; D013792:Thalidomide / Q000009:adverse effects*; D018608:Ultrasonography, Doppler; D014647:Varicose Ulcer / Q000000981:diagnostic imaging / Q000209:etiology*
chemical_list: D013723:Teratogens; D013792:Thalidomide