[Sensory-nerves and airway inflammation: interaction with beta-2-adrenoceptor agonists].
beta-2-adrenoceptor agonists are used as bronchodilatators in asthma and chronic obstructive pulmonary disease (COPD) treatment. However, regular single use of these molecules may enhance bronchial hyperresponsiveness, a component of asthma and COPD. Indeed, pathophysiologic mechanisms underlying bronchial hyperresponsiveness remain unclear. Sensory nerves have been recently found in the respiratory tract and they play an important role in the regulation of bronchial responsiveness through the release of tachykinins and activation of vanilloid TRPV1 (Transient Receptor Potential Vanilloid 1) receptors. The purpose of this review is to highlight the most recent findings concerning the interactions between beta-2-adrenoceptor agonists and bronchial sensory nerves.
Advenier
C
C
Laboratoire de pharmacologie de l'obstruction bronchique (EA 220 - Faculté de Médecine Paris-Ile de France Ouest), Ufr Biomédicale des Saint-Pères, 45, rue des Saints-Pères. F 75270 Paris Cedex 06. charles.advenier@wanadoo.fr
Faisy
C
C
Naline
E
E
Planquette
B
B
Devillier
P
P
D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000818:Animals; D001980:Bronchi / Q000187:drug effects / Q000502:physiology; D001993:Bronchodilator Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D012140:Respiratory Tract Diseases / Q000188:drug therapy* / Q000473:pathology*
D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents