Pro-resolution properties of macrophages in renal injury.
Macrophages are inflammatory cells with important roles in the propagation of renal injury. More recently they have also been shown to be important in the resolution of inflammation. Wang et al. show that macrophages can be modulated ex vivo by cytokine stimulation, localize to renal tissue, and slow progression of experimental glomerular inflammation. Thus strategies targeting macrophage function have considerable therapeutic potential.
Kluth
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Medical Research Council Centre for Inflammation Research, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom. david.kluth@ed.ac.uk
D000818:Animals; D016207:Cytokines / Q000502:physiology; D005921:Glomerulonephritis / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D007249:Inflammation; D007668:Kidney / Q000166:cytology / Q000473:pathology; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology* / Q000637:transplantation; D051379:Mice
D016207:Cytokines