Brain matrix: structure, turnover and necessity.
Aided by mice with multiple deleted brain matrix protein genes, the biochemical analysis of mouse brain matrix molecules indicates a constitutive production of more proteoglycans than can be integrated in multimolecular matrix structures. Possible functions of non-matrix integrated proteoglycans, and aspects of incomplete compensatory mechanisms in knockout mice are discussed.
Rauch
U
U
Vessel Wall Biology Section, Institute for Experimental Medical Science, Lund University, Lund, Sweden. uwe.rauch@med.lu.se
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005109:Extracellular Matrix / Q000737:chemistry* / Q000378:metabolism*; D051379:Mice