[Comparative study of behavioral effects of cortexin and cerebrolysine upon intraventricular and intraperitoneal administration in rats].
The comparative central effects of polypeptide drugs cortexin and cerebrolysin were studied in Wistar rats after introduction into the cerebral ventriculi in a dose range from 1 mg to 10 mg and 100 mg and after intraperitoneal injections in a dose of 1 mg/kg. Both drugs produced a moderate psychostimulant action, cortexin being more effective as compared to cerebrolysin. This effect was confirmed by all methods studied, including open field, elevated plus-maze, intruder-resident, and self-stimulation of the lateral hypothalamus. It is suggested that cortexin and cerebrolysin have similar mode of action, while cortexin is more effective than cerebrolysin. A difference between the intraventricular and intraperitoneal effects of drugs was that in the first case both drugs produced a moderate anxiolytic action, while in the second case an anxiogenic effect was registered. The central anxiolytic effect of drugs is probably related to a nonspecific action of polypeptides administered via brain ventriculi.
Shabanov
P D
PD
Lebedev
A A
AA
Pavlenko
V P
VP
Ganapol'skiĭ
V P
VP
D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids; D014151:Anti-Anxiety Agents; D000697:Central Nervous System Stimulants; D036341:Intercellular Signaling Peptides and Proteins; D018696:Neuroprotective Agents; D010455:Peptides; C006952:cerebrolysin; C056590:cortexin