title: Prospective evaluation of the negative predictive value of V/Q SPECT using 99mTc-Technegas.
abstract: OBJECTIVE
  To verify the negative predictive value of pulmonary ventilation/perfusion scintigraphy with single photon emission computed tomography (V/Q SPECT) in ruling out pulmonary thromboembolism.
  
  
  METHODS
  V/Q SPECT using 99mTc-Technegas was performed on 584 patients to rule out pulmonary thromboembolism between October 2004 and July 2005. Pulmonary thromboembolism was defined as any clear-cut vascular mismatch, regardless of size. Indeterminate scans were defined as cases having matching vascular type defects with a corresponding X-ray abnormality, or cases with equivocal mismatches. Other patterns were considered negative for pulmonary thromboembolism. Outcome data was gathered >3 months after the scan. Absence of pulmonary thromboembolism was defined as any patient still alive at least 3 months after the scan, with no anticoagulation treatment and no proof of pulmonary thromboembolism by other techniques, either at the time of the scan or during follow-up, or death by other causes.
  
  
  RESULTS
  One hundred and eight patients (19%) had a positive pulmonary thromboembolism reading, 18 (3%) an indeterminate study, and 458 (78%) patients had a negative reading for pulmonary thromboembolism. There were 189 patients with an abnormal chest X-ray. The mean follow-up time was 165 days. Of the 458 patients classified as negative for pulmonary thromboembolism, patients receiving chronic anticoagulation for other causes were excluded from follow-up (n=53), which left 405 patients for final analysis. There were no pulmonary thromboembolism-related deaths in the negative group. Six patients were identified as false negatives. The negative predictive value is estimated at 98.5%.
  
  
  CONCLUSIONS
  SPECT pulmonary scintigraphy using 99mTc-Technegas demonstrates a high negative predictive value and a low indeterminate rate.
authors.affiliation: Department of Nuclear Medicine and Radiobiology, Centre Hospitalier Universitaire de Sherbrooke, Quebec, Canada. michel.leblanc@dr.cgocable.ca
authors.forename: Michel
authors.initials: M
authors.lastname: Leblanc
authors.forename: Félix
authors.initials: F
authors.lastname: Leveillée
authors.forename: Eric
authors.initials: E
authors.lastname: Turcotte
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; C056708:Technegas; D013670:Sodium Pertechnetate Tc 99m