title: Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes.
abstract: The present study was aimed to investigate the activity of Thai medicinal plants on inflammation caused by Propionibacterium acnes in terms of free radical scavenging and cytokine reducing properties. P. acnes have been recognized as pus-forming bacteria triggering an inflammation in acne. Antioxidant activity was determined by DPPH scavenging and NBT reduction assay. The result showed that Garcinia mangostana possessed the most significant antioxidant activity and reduced reactive oxygen species production. Houttuynia cordata, Eupatorium odoratum, and Senna alata had a moderate antioxidant effect. In addition, Garcinia mangostana extracts could reduce the TNF-alpha production as determined by ELISA. Garcinia mangostana was highly effective in scavenging free radicals and was able to suppress the production of pro-inflammatory cytokines. This study has identified the promising source of anti-inflammatory agent which could be useful in treatment of acne vulgaris.
authors.affiliation: Department of Microbiology, Faculty of Pharmacy, Mahidol University, Rachathevi, Bangkok, Thailand. scmtd@mahidol.ac.th
authors.forename: Mullika Traidej
authors.initials: MT
authors.lastname: Chomnawang
authors.forename: Suvimol
authors.initials: S
authors.lastname: Surassmo
authors.forename: Veena S
authors.initials: VS
authors.lastname: Nukoolkarn
authors.forename: Wandee
authors.initials: W
authors.lastname: Gritsanapan
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001713:Biphenyl Compounds; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D029762:Garcinia mangostana; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D009580:Nitroblue Tetrazolium / Q000737:chemistry; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011425:Propionibacterium acnes / Q000472:pathogenicity*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000187:drug effects
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D009580:Nitroblue Tetrazolium; C004931:1,1-diphenyl-2-picrylhydrazyl