title: MP4- and MOG:35-55-induced EAE in C57BL/6 mice differentially targets brain, spinal cord and cerebellum.
abstract: Mechanism-oriented studies of EAE rely mostly on gene-modified mice on the C57BL/6 background. Here we report that MP4-induced EAE displays characteristic differences in CNS pathology as compared to MOG peptide 35-55-elicited disease. While in the latter, the topology of CNS infiltration remained unchanged throughout the disease, in MP4-induced EAE it was dynamic and stage-dependent shifting from the brain to the spinal cord and finally to the cerebellum. Unlike in the MOG peptide model, the frequencies and sizes of CNS lesions in MP4-induced disease showed a clear correlation with clinical disease severity. These characteristic features of MP4-induced EAE may contribute to modelling the complex spectrum of disease manifestations seen in MS.
authors.affiliation: Institute I for Anatomy, University of Cologne, D-50931 Cologne, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Kuerten
authors.forename: Dilyana A
authors.initials: DA
authors.lastname: Kostova-Bales
authors.forename: Lukas P
authors.initials: LP
authors.lastname: Frenzel
authors.forename: Justine T
authors.initials: JT
authors.lastname: Tigno
authors.forename: Magdalena
authors.initials: M
authors.lastname: Tary-Lehmann
authors.forename: Doychin N
authors.initials: DN
authors.lastname: Angelov
authors.forename: Paul V
authors.initials: PV
authors.lastname: Lehmann
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced* / Q000473:pathology*; D005260:Female; D006023:Glycoproteins / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D004676:Myelin Basic Protein / Q000008:administration & dosage*; D018991:Myelin Proteolipid Protein / Q000008:administration & dosage*; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments / Q000008:administration & dosage*; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D006023:Glycoproteins; C101821:MP4 protein, chimeric; D004676:Myelin Basic Protein; D018991:Myelin Proteolipid Protein; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; D011993:Recombinant Fusion Proteins; C445081:myelin oligodendrocyte glycoprotein (35-55)