title: [Spinal anesthesia and postoperative analgesia with intrathecal morphine for orthopedic surgery].
abstract: The aim of this study was to evaluate the analgesic efficacy and side effects of intrathecal morphine in the dose range 0.2-0.5 mg. One-hundred patients scheduled for elective lower limb orthopedic operation under spinal anesthesia using hyperbaric or isobaric bupivacaine 0.5% with morphine in dose from 0.2 to 0.5 mg. Pain score, duration of analgesia and the incidence of adverse effects like nausea, vomiting, pruritus, urinary retention and respiratory depression were assessed for 48 hr postoperatively. There were significant differences in the duration and efficacy analgesia and the incidence of pruritus the morphine dose-related. We did not observe the increased frequency of nausea and vomiting with increased dose. The respiratory depression not observed in connection with intrathecal morphine. The evidence from this current study suggests that spinal anesthesia with combination of local anesthetic and morphine can be employed to provide safe and efficacious analgesia in patients undergoing orthopedic operations. The adverse effects which developed due to intrathecal morphine were able to treat with success.
authors.affiliation: Klinika Reumoortopedii, Instytut Reumatologii im. prof dr hab. med. Eleonory Reicher.
authors.forename: Barbara
authors.initials: B
authors.lastname: Lisowska
authors.forename: Renata
authors.initials: R
authors.lastname: Cwiek
authors.forename: Paweł
authors.initials: P
authors.lastname: Małdyk
authors.forename: Anita
authors.initials: A
authors.lastname: Hofmeister
authors.forename: Piotr
authors.initials: P
authors.lastname: Luboiński
mesh_terms: D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D000768:Anesthesia, General; D000775:Anesthesia, Spinal; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D019637:Orthopedic Procedures; D010149:Postoperative Pain / Q000209:etiology; D011183:Postoperative Complications / Q000139:chemically induced* / Q000517:prevention & control; D020250:Postoperative Nausea and Vomiting / Q000139:chemically induced; D011537:Pruritus / Q000139:chemically induced; D012129:Respiratory Function Tests; D016055:Urinary Retention / Q000139:chemically induced
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine