title: Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil.
abstract: As there was not any data on Chlamydia pneumoniae (TWAR) infections in Brazil so far, a prospective cohort study of adult patients hospitalized due to CAP was carried out for one year in a Brazilian university general hospital to detect the incidence of CAP by Chlamydophila pneumoniae (TWAR) for one year. During a whole year 645 consecutive patients hospitalized due to an initial presumptive diagnosis of respiratory diseases by ICD-10 (J00-J99), excluding upper respiratory diseases, were screened; 59 consecutive patients with CAP were diagnosed. They had determinations of serum antibodies to C. pneumoniae by microimmunofluorescence at the Infectious Diseases Laboratory of University of Louisville (KY, USA); 37 patients (63.8%) had seroreactivity to TWAR antigens, from which 23 (39.6%) had previous infection; 3 patients (5.2%) were diagnosed with CAP by TWAR and got cured. The incidence of TWAR CAP in our hospital by seroconversion was 5.2%. Our incidence of 5.2% is probably underestimated since TWAR culture was not available; we suggest that Real-Time PCR be used along with other diagnostic methods in future studies to detect the actual incidence of TWAR CAP. We propose that the serological criterion of IgM >1:16 alone to the diagnosis of acute infection by TWAR are discontinued due a lack of specificity.
authors.affiliation: Hospital das Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. mariab@terra.com.br
authors.forename: Maria Bernadete
authors.initials: MB
authors.lastname: Chedid
authors.forename: Márcio Fernandes
authors.initials: MF
authors.lastname: Chedid
authors.forename: Darcy Oliveira
authors.initials: DO
authors.lastname: Ilha
authors.forename: Mary Clarisse
authors.initials: MC
authors.lastname: Bozzetti
authors.forename: Letícia
authors.initials: L
authors.lastname: Chaves
authors.forename: Daniela
authors.initials: D
authors.lastname: Griza
authors.forename: Paulo Roth
authors.initials: PR
authors.lastname: Dalcin
mesh_terms: D000208:Acute Disease; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000453:epidemiology; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D005455:Fluorescent Antibody Technique / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D011446:Prospective Studies
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M