Inhibitory effect of Ipomoea aquatica extracts on glucose absorption using a perfused rat intestinal preparation.
Investigations were carried out to evaluate the effect of Ipomoea aquatica aqueous and dichloromethane/methanol extracts on the glucose absorption using a rat intestinal preparation in situ. Extracts orally tested at the dose of 160 mg/kg exerted a significant inhibitory effect on glucose absorption when compared with control animals. The most pronounced effect was observed with the aqueous extract. Ouabain used as reference inhibitor strongly inhibited glucose absorption. On the other hand both plant extracts inhibited the gastrointestinal motility suggesting that the inhibition of glucose absorption is not due to the acceleration of intestinal transit.
Sokeng
S D
SD
Department of Biological Sciences, University of Ngaoundere, P.O. Box 454 Ngaoundere, Cameroon. dsokeng@yahoo.com
Rokeya
B
B
Hannan
J M A
JM
Junaida
K
K
Zitech
P
P
Ali
L
L
Ngounou
G
G
Lontsi
D
D
Kamtchouing
P
P
D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy; D005769:Gastrointestinal Motility / Q000187:drug effects; D005947:Glucose / Q000493:pharmacokinetics*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D027741:Ipomoea; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D051381:Rats; D020318:Rats, Long-Evans
D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005947:Glucose