[Clinical significance of AFP-L3 variants determined by micro centrifugal column].
OBJECTIVE
To evaluate the clinical significance of AFP-L3 in patients with hepatocellular carcinoma.


METHODS
Serum AFP-L3 variants were separated by micro centrifugal column, and detected by chemiluminescence.


RESULTS
AFP and AFP-L3 levels were higher in patients with hepatocellular carcinoma than those in patients with chronic hepatitis (P<0.001); as a diagnostic target, the sensitivity and specificity of AFP-L3 were 72.3 percent and 97.2 percent, respectively. Eight patients with hepatitis have higher AFP-L3, but none of them were found with carcinoma by CT three months later.


CONCLUSIONS
AFP-L3 is very useful in the diagnosis of patients with hepatocellular carcinoma.
Wang
Yong-zhong
YZ
The 3rd People's Hospital of Changzhou, Changzhou 213001, China. wyz0003@163.com
Luo
Li-bo
LB
Wu
Guo-xiang
GX
Chen
Min
M
Ruan
Li-hua
LH
Pu
Xiang-ke
XK
Hang
Shuang-rong
SR
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis*; D002498:Centrifugation; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D000509:alpha-Fetoproteins / Q000032:analysis* / Q000302:isolation & purification
D000509:alpha-Fetoproteins