RNA polymerase II: just stopping by.
In this issue of Cell, Guenther et al. (2007) analyze the presence of chromatin marks and RNA polymerase at transcription start sites in the human genome. Their results reveal that many "inactive" genes harbor histone marks associated with active transcription at their 5' ends and that although these genes initiate transcription, they do not generate full-length transcripts.
Lorincz
Matthew C
MC
Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. mlorincz@interchange.ubc.ca
Schübeler
Dirk
D
D002843:Chromatin / Q000378:metabolism; D005786:Gene Expression Regulation; D015894:Genome, Human; D006801:Humans; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D002843:Chromatin; D012319:RNA Polymerase II