[Fetuin A and matrix GLA protein in long standing type I diabetic patients without ischaemic heart disease].
Fetuin A and matrix GLA protein--MGP are known as extraosseus calcification inhibitors. The aim of the study was to assess the dependence between metabolic status and fetuin A and matrix GLA protein levels in type 1 diabetic patients without ischaemic heart disease. The study was performed in a group consisting of 35 patients with type 1 diabetes mellitus (22 women and 13 men). Mean age of the studied group equaled 38.8 +/- 11.24 years, duration of diabetes mellitus 20.77 +/- 10.11 years. Fetuin A significantly correlated with HDL-cholesterol (r = 0.45; p = 0.007). Total cholesterol, LDL-chol and triglicerides correlated with HbA1c (r = 0.40, p = 0.03; r = 0.41, p = 0.03 and r = 0.37, p = 0.05), HDL-chol significantly correlated with glucose level at the examination day (r = 0.52, p = 0.04). There were also positive correlations of trigliceride with uric acid (r = 0.47, p = 0.09) and cystatin C (r = 0.44, p = 0.02). There were no correlation of MGP with other examined parameters. Initial results of fetuin A and MGP levels in long-term type 1 diabetic patients without ischaemic heart disease draws attention to new parameters in macroangiopathy development.
Galicka-Latała
Danuta
D
Katedra i Klinika Chorób Metabolicznych, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie. Danuta_Latala@yahoo.com
Kuźniewski
Marek
M
Fedak
Danuta
D
Konduracka
Ewa
E
Sieradzki
Jacek
J
D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002135:Calcium-Binding Proteins / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D003925:Diabetic Angiopathies / Q000209:etiology; D003929:Diabetic Neuropathies / Q000175:diagnosis / Q000209:etiology; D016326:Extracellular Matrix Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology; D014280:Triglycerides / Q000097:blood; D000509:alpha-Fetoproteins / Q000032:analysis* / Q000378:metabolism*; D000097568:Matrix Gla Protein
D015415:Biomarkers; D002135:Calcium-Binding Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D016326:Extracellular Matrix Proteins; D014280:Triglycerides; D000509:alpha-Fetoproteins; D000097568:Matrix Gla Protein