Indices of oxidative stress in pregnancy with fetal growth restriction.
Intrauterine fetal growth restriction (IUGR), the main cause of premature delivery and fetal mortality, has been suggested to involve oxidative stress. We found elevated values of indices of oxidative stress in the blood serum of pregnant women with IUGR: increased levels of malondialdehyde and 4-hydroxyalkenals, decreased activity of alpha-1-antitrypsin and decreased total antioxidant capacity of the serum, with respect to healthy pregnancy. Twenty day treatment with 3 g of l-arginine and 75 mg of acetylsalicylic acid daily resulted in a decrease of the level of lipid peroxidation products and augmentation of alpha-1-antitrypsin activity. This study confirms the occurrence of oxidative stress in IUGR and demonstrates the beneficial effect of arginine/acetylsalicylic acid therapy in reducing oxidative stress in IUGR.
Karowicz-Bilinska
Agata
A
High-Risk Pregnancy Unit, Medical University of Łódz, Lodz, Poland. agakar@interia.pl
Kedziora-Kornatowska
Kornelia
K
Bartosz
Grzegorz
G
D000328:Adult; D001120:Arginine / Q000008:administration & dosage / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D011247:Pregnancy; D044967:Serum / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D015415:Biomarkers; C043392:SERPINA1 protein, human; D000515:alpha 1-Antitrypsin; D008315:Malondialdehyde; D001120:Arginine; D001241:Aspirin