title: Invasive zygomycosis in transplant recipients.
abstract: Zygomycosis are rare fungal infections occurring mainly in immunocompromised patients. To date only 160 cases have been published in transplant recipients. We report four new cases of zygomycosis in transplant recipients illustrating the large clinical spectrum of this infection: one disseminated infection with heart involvement and one rhinocerebral infection with dissemination in two bone marrow transplant recipients, one cutaneous infection in a liver and one pulmonary infection in a kidney recipient. All cases, except the cutaneous infection that was accessible to surgical resection and a systemic antifungal treatment, were fatal. In transplant recipients cumulating risk factors for zygomycosis, a high index of suspicion is required. Early diagnosis and combining surgery with systemic amphotericin-B are mandatory to improve survival rates.
authors.affiliation: Service of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland.
authors.forename: Ilker
authors.initials: I
authors.lastname: Uçkay
authors.forename: Yves
authors.initials: Y
authors.lastname: Chalandon
authors.forename: Pascal
authors.initials: P
authors.lastname: Sartoretti
authors.forename: Peter
authors.initials: P
authors.lastname: Rohner
authors.forename: Thierry
authors.initials: T
authors.lastname: Berney
authors.forename: Karine
authors.initials: K
authors.lastname: Hadaya
authors.forename: Christian
authors.initials: C
authors.lastname: van Delden
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D016867:Immunocompromised Host; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis; D009894:Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D011183:Postoperative Complications / Q000382:microbiology*; D012233:Rhizopus; D020096:Zygomycosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B