title: Hyperhomocysteinemia and central retinal vein occlusion in Iranian population.
abstract: OBJECTIVE
  To evaluate total plasma homocysteine level during the acute phase of central retinal vein occlusion (CRVO) in the Iranian population and determine whether hyperhomocysteinemia is also a risk factor for CRVO.
  
  
  METHODS
  Fifty-four patients with recently diagnosed CRVO were studied. Their fasting total plasma homocysteine level was compared with a matched control group of 51 patients evaluated in the same clinic for a non-retinal disease diagnosis.
  
  
  RESULTS
  The mean total plasma homocysteine level was 14.76+/-7.67 micromol/l in cases, and 11.42+/-3.74 micromol/l in control subjects. It showed a significant difference (P=0.005) in mean plasma homocysteine level between cases and control group. Odds ratio of CRVO for individuals with hyperhomocysteinemia was 2.88 (95% CI=1.08-7.71 and P=0.03). The overall multivariable-adjusted odds of CRVO in participants with plasma homocysteine level above 15 micromol/l was 4.71 (95% CI=1.46-15.19 and P=0.009) Hyperhomocysteinemia was not statistically different in each age group (<60 years: 27%, 61-70 years: 33.3%, 71-80 years: 31.6%, >81 years: 33.3%, Chi-square test, P=0.98).
  
  
  CONCLUSIONS
  Elevated total plasma homocysteine level is an independent risk factor for CRVO in Iranian population. In addition to an evaluation of all conventional cardiovascular risk factors, measurement of total homocysteine for evidence of hyperhomocysteinemia may be important in the initial investigation and management of patients with CRVO.
authors.affiliation: Farabi Eye Research Center, Department of Ophthalmology, Tehran University of Medical Sciences, Quazvin Square, Tehran 1336616351, Iran. sasanimii@yahoo.com
authors.forename: Sasan
authors.initials: S
authors.lastname: Moghimi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Najmi
authors.forename: Hooshang
authors.initials: H
authors.lastname: Faghihi
authors.forename: Reza
authors.initials: R
authors.lastname: Karkhaneh
authors.forename: Mohammad Sadegh
authors.initials: MS
authors.lastname: Farahvash
authors.forename: Maryam
authors.initials: M
authors.lastname: Maghsoudipour
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications*; D007492:Iran; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012170:Retinal Vein Occlusion / Q000097:blood / Q000209:etiology*; D012307:Risk Factors
chemical_list: D006710:Homocysteine