Blastomyces antigen detection for monitoring progression of blastomycosis in a pregnant adolescent.
Although disseminated blastomycosis is a rare complication in pregnancy, delay in diagnosis and treatment can be fatal. We investigate the use of the Blastomyces urine antigen in diagnosis following disease progression in the intrapartum, postpartum, and neonatal periods. We describe a case of disseminated blastomycosis in a pregnant adolescent and review the pertinent literature regarding treatment and monitoring blastomycosis in pregnancy and the neonatal periods. This is the first reported case in which the Blastomyces urine antigen is utilized as a method of following disease activity during pregnancy confirming absence of clinically evident disease in a neonate. Urine antigen detection for blastomycosis can be useful for following progression of disease in patients with disseminated blastomycosis in both the intrapartum and postpartum periods.
Tarr
Megan
M
Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.
Marcinak
John
J
Mongkolrattanothai
Kanokporn
K
Burns
Jennifer L
JL
Wheat
L Joseph
LJ
Durkin
Michelle
M
Ismail
Mahmoud
M
D000293:Adolescent; D000946:Antigens, Fungal / Q000652:urine*; D001758:Blastomyces / Q000302:isolation & purification*; D001759:Blastomycosis / Q000188:drug therapy / Q000382:microbiology / Q000652:urine*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000382:microbiology* / Q000652:urine*
D000946:Antigens, Fungal