title: Total synthesis of luotonin A and 14-substituted analogues.
abstract: A new and concise synthesis of luotonin A was achieved from the previously described compounds ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate and 1-(2-nitrophenyl)prop-2-en-1-one. New 14-substituted luotonin A analogues were prepared using 14-chloroluotonin A as the key intermediate.
authors.affiliation: Unit for Organic Chemistry, Department of Biosciences and Nutrition, Karolinska Institute, SE-14157 Huddinge, Sweden.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Mason
authors.forename: Jan
authors.initials: J
authors.lastname: Bergman
mesh_terms: D002713:Chlorine / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011758:Pyrroles; D011809:Quinones; C480761:luotonin A; D002713:Chlorine