title: Biochemistry. PI3K charges ahead.
authors.affiliation: Department of Systems Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
authors.forename: Jennifer Y
authors.initials: JY
authors.lastname: Lee
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Engelman
authors.forename: Lewis C
authors.initials: LC
authors.lastname: Cantley
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D020134:Catalytic Domain; D002462:Cell Membrane / Q000201:enzymology; D049109:Cell Proliferation; D002470:Cell Survival; D019281:Dimerization; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics*; D019869:Phosphatidylinositol 3-Kinases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D021122:Protein Subunits; D018909:src Homology Domains
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D021122:Protein Subunits