title: Polarization of B effector cells in Sjögren's syndrome.
abstract: Analysis of salivary glands of patients with primary Sjögren's syndrome has yielded conflicting results with respect to T helper (Th)1/Th2 polarization. This balance might parallel the progress of the local lesions. B-cells are now taking center stage in this disease. They can also be primed to differentiate into two cytokine-production pathways, dubbed B effector (Be) 1 and Be2 cells. This is discussed in the light of our recent finding that Be1 accompany Th1, while Be2 accompany in the tissue lesions.
authors.affiliation: Laboratory of Immunology, Brest University Medical School Hospital, Brest, France.
authors.forename: Capucine
authors.initials: C
authors.lastname: Daridon
authors.forename: Thomas
authors.initials: T
authors.lastname: Guerrier
authors.forename: Valérie
authors.initials: V
authors.lastname: Devauchelle
authors.forename: Alain
authors.initials: A
authors.lastname: Saraux
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Pers
authors.forename: Pierre
authors.initials: P
authors.lastname: Youinou
mesh_terms: D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D012469:Salivary Glands / Q000276:immunology; D012859:Sjogren's Syndrome / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology