title: The sequence of events that underlie quantal transmission at central glutamatergic synapses.
abstract: The properties of synaptic transmission were first elucidated at the neuromuscular junction. More recent work has examined transmission at synapses within the brain. Here we review the remarkable progress in understanding the biophysical and molecular basis of the sequential steps in this process. These steps include the elevation of Ca2+ in microdomains of the presynaptic terminal, the diffusion of transmitter through the fusion pore into the synaptic cleft and the activation of postsynaptic receptors. The results give insight into the factors that control the precision of quantal transmission and provide a framework for understanding synaptic plasticity.
authors.affiliation: Brandeis University, Department of Biology, MS 008, 415 South Street, Waltham, Massachusetts 02454-9110, USA. lisman@brandeis.edu
authors.forename: John E
authors.initials: JE
authors.lastname: Lisman
authors.forename: Sridhar
authors.initials: S
authors.lastname: Raghavachari
authors.forename: Richard W
authors.initials: RW
authors.lastname: Tsien
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D020013:Calcium Signaling / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D008561:Membrane Fusion / Q000502:physiology; D018091:Receptors, AMPA / Q000737:chemistry / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism* / Q000648:ultrastructure; D013570:Synaptic Membranes / Q000378:metabolism / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D018091:Receptors, AMPA; D018698:Glutamic Acid