title: Loudness dependence of auditory evoked potentials is not associated with polymorphisms or haplotypes in the serotonin transporter gene in a community-based sample of German healthy volunteers.
abstract: Three previous studies found an association between the loudness dependence (LD) of the auditory evoked potential N1/P2 component, an indicator of central serotonergic neurotransmission, and a functional variation in the promoter region of the 5-hydroxytryptamine transporter (5-HTT) gene (rs4795541 Ins/Del). The results of these three studies were contradictory and possibly biased by the recruitment methods used. We therefore aimed to re-investigate this association (rs4795541) using a community-based sample randomly selected from the general population and to extend the analysis to four further putative variations in this gene (rs3783594, rs3794808, rs140701, rs6354). In this carefully recruited sample, genotypes or haplotypes under investigation were not associated with LD. We speculate that the LD endophenotype depends more on genetic variations in components of the serotonergic system controlling release than on those controlling the uptake mechanism.
authors.affiliation: Department of Psychiatry, Ruhr-University Bochum, Germany. georg.juckel@wkp-lwl.org
authors.forename: Georg
authors.initials: G
authors.lastname: Juckel
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hegerl
authors.forename: Ina
authors.initials: I
authors.lastname: Giegling
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Mavrogiorgou
authors.forename: Jürgen
authors.initials: J
authors.lastname: Gallinat
authors.forename: Holger
authors.initials: H
authors.lastname: Augustin
authors.forename: Christoph
authors.initials: C
authors.lastname: Mulert
authors.forename: Oliver
authors.initials: O
authors.lastname: Pogarell
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
mesh_terms: D001307:Auditory Perception; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D015870:Gene Expression / Q000235:genetics; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes; D006304:Health Status; D006311:Hearing Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008144:Loudness Perception; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012111:Residence Characteristics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013001:Somatoform Disorders / Q000175:diagnosis / Q000453:epidemiology; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins