n-6 and n-3 fatty acids ratio and vitamin E in porcine maternal diet influence the antioxidant status and immune cell eicosanoid response in the progeny.
Five groups of lactating sows were fed diets containing 8% of either added rapeseed oil, fish oil or sunflower oil and 60 mg vitamin E/kg feed, or the diets with sunflower oil and fish oil, respectively, supplemented with 500 mg vitamin E/kg. Supplementation of vitamin E to the sows increased the concentration of alpha-tocopherol of the muscle, and addition of sunflower oil decreased the activity of glutathione peroxidase in liver cytosol compared to fish oil and rapeseed oil. The composition of fatty acids of alveolar macrophages (AM) of piglets was influenced by the dietary fat sources provided the sows, i.e., the ratio of n-6:n-3 fatty acids was highest in AM of piglets suckling sows of the sunflower oil treatments, and lowest in AM of piglets suckling sows fed fish oil with the rapeseed oil treatment in between. The ex vivo synthesis of prostaglandin E(2) and thromboxane B(2) in AM of piglets suckling sows fed sunflower oil was elevated compared to piglets suckling sows fed fish oil. Vitamin E supplementation to sows enhanced the synthesis of these eicosanoids, and also the concentration of alpha-tocopherol in the AM of the piglets.
Lauridsen
Charlotte
C
Department of Animal Health, Welfare and Nutrition, Aarhus University, Research Centre Foulum, PO Box 50, DK-8830 Tjele, Denmark. Charlotte.lauridsen@agrsci.dk
Stagsted
Jan
J
Jensen
Søren Krogh
SK
D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D015777:Eicosanoids / Q000378:metabolism*; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D043371:Fatty Acids, Omega-6 / Q000378:metabolism*; D005260:Female; D008892:Milk; D010938:Plant Oils / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D000074242:Sunflower Oil; D013552:Swine; D014810:Vitamin E / Q000378:metabolism*
D000975:Antioxidants; D004041:Dietary Fats; D015777:Eicosanoids; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D010938:Plant Oils; D000074242:Sunflower Oil; D014810:Vitamin E