Subsequent therapeutic options and outcome in couples who fail to fertilize despite in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).
OBJECTIVE
Failed fertilization with ICSI in women having at least five mature oocytes retrieved is uncommon. The present study evaluated 19 such patients to determine--based on this outcome--what option they would choose next and what the outcome would be.


METHODS
The study requirements included females age < or = 43 and use of ejaculated sperm.


RESULTS
Five of 19 women (26.3%) had severe oligoasthenozoospermia. Options chosen were 1) donor egg (n = 3), 2) donor embryo (n = 1), 3) donor sperm (n = 1), 4) treatment cessation (n = 3), 5) resuming IVF-ET and ICSI (n = 11). Live deliveries occurred in 1) (n = 2), 2) (n = 1), and 5) (n = 4).


CONCLUSIONS
When faced with failed fertilization with ICSI a small majority of women (11/19, 57.9%) chose to still try with their own gametes and some succeeded (36.3%). These data may be helpful in counseling couples who fail fertilization despite IVF with ICSI in making a decision as to their next therapeutic choice.
Horwath
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The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA.
Check
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Katsoff
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Amui
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Brasile
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D000328:Adult; D003376:Counseling; D036861:Delivery, Obstetric; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007248:Infertility, Male / Q000628:therapy*; D007316:Insemination, Artificial, Heterologous; D008297:Male; D010063:Ovum / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000002:abnormalities; D016896:Treatment Outcome