title: The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir.
abstract: The best strategy for control of cytomegalovirus (CMV) infection in lung transplant patients is still not determined. The aim of this study was to document the incidence of CMV infection in a cohort of lung transplant recipients under universal prophylaxis with intravenous ganciclovir. All patients received immunosuppressive regimens consisting of cyclosporine, azathioprine, and prednisone. Regardless of CMV serostatus, intravenous ganciclovir was prescribed for every patient in the first 3 months post-transplantation. CMV infection was defined as the detection of CMV pp65 in leukocytes. Eighty-two lung transplant patients were included over a 5-year period. The incidence of CMV infection in the first year post-transplantation was 68.3%, occurring after a median length of 114 days (range, 26-343 days). This study revealed a high incidence of CMV infection in the first year following lung transplantation despite prolonged universal ganciclovir prophylaxis.
authors.affiliation: Laboratory of Transplant Immunology, Santa Casa Complexo Hospitalar, Avenida Independência 75, 94035-075 Porto Alegre, RS, Brazil. regina@santacasa.tch.br
authors.forename: Regina
authors.initials: R
authors.lastname: Schröeder
authors.forename: Tatiana
authors.initials: T
authors.lastname: Michelon
authors.forename: João
authors.initials: J
authors.lastname: Wurdig
authors.forename: Iara
authors.initials: I
authors.lastname: Fagundes
authors.forename: Sadi
authors.initials: S
authors.lastname: Schio
authors.forename: Leticia
authors.initials: L
authors.lastname: Sanchez
authors.forename: José J
authors.initials: JJ
authors.lastname: Camargo
authors.forename: Teresa C
authors.initials: TC
authors.lastname: Sukkienik
authors.forename: Alessandro C
authors.initials: AC
authors.lastname: Pasqualotto
authors.forename: Jorge
authors.initials: J
authors.lastname: Neumann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage*; D002648:Child; D015331:Cohort Studies; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage*; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D007262:Infusions, Intravenous; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D012189:Retrospective Studies
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir