Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists.
A series of constrained piperidine analogues were synthesized as novel muscarinic M(3) receptor antagonists. Evaluation of these compounds in binding assays revealed that they not only have high affinity for the M(3) receptor but also have high selectivity over the M(2) receptor.
Kumar
Naresh
N
Ranbaxy Research Laboratories, New Drug Discovery Research, Department of Medicinal Chemistry, Gurgaon, Haryana 122 001, India. n.kumar@ranbaxy.com
Kaur
Kirandeep
K
Aeron
Shelly
S
Dharmarajan
Sankaranarayanan
S
Silamkoti
Arun D V
AD
Mehta
Anita
A
Gupta
Suman
S
Chugh
Anita
A
Gupta
Jang B
JB
Salman
Mohammad
M
Palle
Venkata P
VP
Cliffe
Ian A
IA
D018727:Muscarinic Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D043587:Receptor, Muscarinic M3 / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D018727:Muscarinic Antagonists; D043587:Receptor, Muscarinic M3