title: [Expresion of E-cadherin and catenins in urothelial carcinomas].
abstract: OBJECTIVE
  We examined the presence of E-cadherin and alpha, beta and gamma catenins detected by immunohistochemistry and correlated with the classic variables: grade, stage and recurrence.
  
  
  METHODS
  The authors evaluated 37 transitional cell carcinomas. Biopsy specimens included no recurrent transitional cell carcinoma (n=19) and recurrent transitional cell carcinoma (n=18). Association of E-cadherin and alpha, beta and gamma catenins immunoreactivity with tumor grade, clinical stage and tumor recurrence was examined.
  
  
  RESULTS
  E-cadherin and gamma catenin expression were related to the clinical stage of the disease, alpha and beta catenins were not correlated with grade, stage and recurrence of disease.
  
  
  CONCLUSIONS
  Decreased E cadherin and gamma catenin expression were associated with advanced stage of the disease.
authors.affiliation: Servicio de Anatomía Patológica, Hospital POVISA, Vigo, Pontevedra. psanmiguel@povisa.es
authors.forename: P
authors.initials: P
authors.lastname: San Miguel Fraile
authors.forename: C
authors.initials: C
authors.lastname: Gómez de María
authors.forename: L
authors.initials: L
authors.lastname: Donis Quintairos
authors.forename: A
authors.initials: A
authors.lastname: Carrera Vazquez
authors.forename: P
authors.initials: P
authors.lastname: Iglesias Martínez
authors.forename: M J
authors.initials: MJ
authors.lastname: Barreiro Barbosa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000096:biosynthesis*; D002295:Carcinoma, Transitional Cell / Q000378:metabolism*; D051177:Catenins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
chemical_list: D015820:Cadherins; D051177:Catenins