title: Effect of fluoxetine alone and in combination with sildenafil in patients with premature ejaculation.
abstract: BACKGROUND
  The aim of this study was to compare the efficacy of fluoxetine alone and combined with sildenafil in patients complaining of premature ejaculation.
  
  
  METHODS
  Ninety-one married potent men, 21-43 years old, with premature ejaculation but without any obvious organic cause were enrolled. Pretreatment evaluation included history, physical examination, and self-administration of the International Index of Erectile Function questionnaire. The patients were randomly divided into two groups: group A patients (n = 48) received 20 mg fluoxetine daily for 4 weeks and then 20 mg as needed 2-3 h before sexual activity for 4 months, and group B patients (n = 43) received group A regimen plus 50 mg sildenafil as needed 1 h before sexual activity for 4 months.
  
  
  RESULTS
  Ejaculatory latency time and intercourse satisfaction significantly improved in group B as compared with group A (p < 0.05).
  
  
  CONCLUSIONS
  Fluoxetine combined with sildenafil seems to provide significantly better ejaculatory latency time and intercourse satisfaction as compared with fluoxetine alone in patients with premature ejaculation.
authors.affiliation: Department of Urology, Motahari Hospital, Jahrom University of Medical Sciences, Jahrom, Shiraz, Iran.
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Hosseini
authors.forename: Hooman
authors.initials: H
authors.lastname: Yarmohammadi
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D004542:Ejaculation; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011446:Prospective Studies; D011687:Purines / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*; D000068677:Sildenafil Citrate; D016037:Single-Blind Method; D013450:Sulfones / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D005473:Fluoxetine; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D017367:Selective Serotonin Reuptake Inhibitors; D000068677:Sildenafil Citrate; D013450:Sulfones