Aseptic meningitis associated with cephalosporins in an infant with trisomy 21.
The authors report a case of aseptic meningitis associated with cephalosporins in an infant. A 1-year-old boy with trisomy 21 received several antimicrobials including cefotaxime and ceftriaxone for bacterial meningitis caused by Haemophilus influenzae b. High fever continued for more than a month, and discontinuation of cefotaxime broke the fever and improved the findings of cerebrospinal fluid. Because third-generation cephalosporins are the first choice against bacterial meningitis for infants, recognition and diagnosis of this rare occurrence of drug-induced aseptic meningitis is important. It is treatable by withdrawal of the drug, and recurrence can be prevented.
Nakajima
Wako
W
Department of Pediatrics, Akita University School of Medicine, Akita, Japan. wakonakajima@hotmail.com
Ishida
Akira
A
Takahashi
Maya
M
Sato
Yoko
Y
Ito
Tomoo
T
Takada
Goro
G
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001831:Body Temperature / Q000187:drug effects; D002097:C-Reactive Protein / Q000378:metabolism; D002511:Cephalosporins / Q000009:adverse effects*; D004314:Down Syndrome / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D006193:Haemophilus influenzae / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D008297:Male; D008582:Meningitis, Aseptic / Q000209:etiology*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002097:C-Reactive Protein