Diffuse large B-cell lymphoma of the cerebellopontine angle in a patient with sudden hearing loss and facial palsy.
Primary lymphoma of the cerebellopontine angle (CPA) is rare in the central nervous system. To our knowledge, there have only been 14 cases reported worldwide so far. Here, we report our findings in a 57-year-old man, who presented with bilateral sudden hearing loss followed by left facial palsy within 1 month. Radiologic study and magnetic resonance imaging showed a homogeneous enhancing mass, 1.6 x 0.5 x 1.1cm in size, in the left CPA cistern region with mild extension to the left internal auditory canal. The tumor was removed through left retromastoid craniectomy, and the histopathologic diagnosis of the tumor was confirmed as diffuse large B-cell type malignant lymphoma. After a series of tumor surveys, there was no evidence of other original lymphoma. The patient was treated with chemotherapy (including intra-Ommaya injection with methotrexate and Ara-C and systemic injection with vincristine, methotrexate and ifosfamide) for the primary CPA lymphoma. He was still alive 19 months after the initial treatment.
Wang
Yao-Ting
YT
Department of Otolaryngology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC. rogerx@ms5.url.com.tw
Su
Hsing-Hao
HH
Hou
Yuyi
Y
Chu
Sau-Tung
ST
Lai
Ping-Hong
PH
Tseng
Hui-Hwa
HH
Lin
Shyh-Jer
SJ
Chou
Yu-Wen
YW
D002528:Cerebellar Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002530:Cerebellopontine Angle; D005158:Facial Paralysis / Q000209:etiology*; D003639:Hearing Loss, Sudden / Q000209:etiology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged