title: Granulomatous infiltration with replacement of liver parenchyma: first case report.
abstract: A 76-year-old man presented with fever, weight loss and abnormal liver function tests. Imaging demonstrated a diffusely abnormal liver, and a liver biopsy revealed a fibrosing granulomatous process infiltrating and replacing liver parenchyma. There was no clinical, radiological or laboratory evidence of autoimmune liver disease, sarcoidosis, lymphoma or tuberculosis. Treatment with steroids resulted in a remarkable resolution of the clinical symptoms and radiology. This is the first case of granulomatous infiltration of the liver replacing normal hepatic parenchyma.
authors.affiliation: Liver Unit, Department of Radiology, St James's University Hospital, Leeds, UK. charles.millson@leedsth.nhs.uk
authors.forename: Charles E
authors.initials: CE
authors.lastname: Millson
authors.forename: J A
authors.initials: JA
authors.lastname: Guthrie
authors.forename: P
authors.initials: P
authors.lastname: Sahay
authors.forename: J I
authors.initials: JI
authors.lastname: Wyatt
mesh_terms: D000368:Aged; D005938:Glucocorticoids / Q000627:therapeutic use; D006099:Granuloma / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone