Hippocampal neurogenesis during normal and pathological aging.
It is now widely accepted that new neurons continue to be added to the brain throughout life including during normal aging. The finding of adult neurogenesis in the hippocampus, a structure involved in the processing of memories, has favored the idea that newborn neurons might subserve cognitive functions. Recent work on human post-mortem tissues and mice models of Alzheimer's disease (AD) has reported persistent hippocampal proliferative capacity during pathological aging. Although it is not yet clear whether neurogenesis leads to the production of fully functional mature neurons in AD brains, these findings open prospects for cell-replacement therapies. Strategies aimed at promoting neurogenesis may also contribute to improve cognitive deficits caused by normal or pathological aging.
Verret
Laure
L
CNRS UMR 5169, Centre de Recherches sur la Cognition Animale, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 4, France.
Trouche
Stéphanie
S
Zerwas
Meike
M
Rampon
Claire
C
D000375:Aging / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D003704:Dementia / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000166:cytology* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
D009419:Nerve Tissue Proteins