title: National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness- Alzheimer's Disease (CATIE-AD): baseline characteristics.
abstract: CATIE-AD was a multicenter effectiveness trial of atypical antipsychotics in patients with agitation and psychosis associated with AD who resided in the community. The study enrolled 421 participants. In this paper we present and discuss baseline characteristics of participants (demographics, cognitive, behavioral, and functional assessments), caregivers (demographics and caregiver burden) and settings at randomization. Those enrolled suffered from a wide range of cognitive impairment, were medically complex and experienced acute psychopathology requiring intervention with atypical antipsychotics. Family members providing the equivalent of institutional care experienced significant depression and caregiver burden. With the increasing prevalence of AD, clinicians and health care planners should look into future needs of those AD sufferers who are residing in community.
authors.affiliation: University of Rochester Medical Center, Program in Neurobehavioral Therapeutics, Monroe Community Hospital, 435 East Henrietta Road, Rochester, NY 14620, USA. saleem_ismail@urmc.rochester.edu
authors.forename: M Saleem
authors.initials: MS
authors.lastname: Ismail
authors.forename: Karen
authors.initials: K
authors.lastname: Dagerman
authors.forename: Pierre N
authors.initials: PN
authors.lastname: Tariot
authors.forename: Shana
authors.initials: S
authors.lastname: Abbott
authors.forename: Sarah
authors.initials: S
authors.lastname: Kavanagh
authors.forename: Lon S
authors.initials: LS
authors.lastname: Schneider
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D010054:Brief Psychiatric Rating Scale; D017028:Caregivers / Q000523:psychology; D003071:Cognition / Q000187:drug effects; D003710:Demography; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009315:National Institute of Mental Health (U.S.); D009483:Neuropsychological Tests; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000209:etiology; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000209:etiology; D011788:Quality of Life; D012107:Research Design; D014481:United States
chemical_list: D014150:Antipsychotic Agents