Management of growth hormone deficiency in adults.
Growth hormone (GH) deficiency in adults is a recognised clinical entity. There is still, however, an ongoing debate of the clinical need and the importance of replacing GH in adults with severe GH deficiency. This review will focus on the overall management of adults with GH deficiency and highlight published data on dose management and treatment goals for various age groups. The efficacy data on quality of life and well-being is discussed and available and growing experience on long-term effects of GH replacement in adults and safety in terms of diabetes mellitus, pituitary tumour recurrence/regrowth and malignancy risk will be reviewed.
Nilsson
Anna G
AG
Department of Endocrinology, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
Svensson
Johan
J
Johannsson
Gudmundur
G
D000328:Adult; D004305:Dose-Response Relationship, Drug; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D019382:Human Growth Hormone / Q000009:adverse effects / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I