Room-temperature copper-catalyzed alpha-arylation of malonates.
An effective method in targeting alpha-aryl malonates is reported. In the presence of a catalytic amount of 2-picolinic acid and CuI, the coupling of aryl iodides with diethyl malonate proceeds smoothly even at room temperature. The high levels of functional group compatibility and exceptionally mild reaction conditions offer this an attractive protocol in accessing a variety of arylated malonates.
Yip
Sau Fan
SF
Open Laboratory of Chirotechnology of Institute of Molecular Technology for Drug Discovery and Synthesis, and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Cheung
Hong Yee
HY
Zhou
Zhongyuan
Z
Kwong
Fuk Yee
FY
D002384:Catalysis; D003300:Copper / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry; D008314:Malonates / Q000737:chemistry*; D013696:Temperature
D006841:Hydrocarbons, Aromatic; D006847:Hydrocarbons, Iodinated; D008314:Malonates; C498810:diethyl malonate; D003300:Copper; C030290:malonic acid