title: Novel functionalized pyridine-containing DTPA-like ligand. Synthesis, computational studies and characterization of the corresponding Gd(III) complex.
abstract: A novel pyridine-containing DTPA-like ligand, carrying additional hydroxymethyl groups on the pyridine side-arms, was synthesized in 5 steps. The corresponding Gd(III) complex, potentially useful as an MRI contrast agent, was prepared and characterized in detail by relaxometric methods and its structure modeled by computational methods.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Università degli Studi di Milano, Viale Abruzzi 42, 20131 Milan, Italy. roberto.artali@tiscali.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Artali
authors.forename: Mauro
authors.initials: M
authors.lastname: Botta
authors.forename: Camilla
authors.initials: C
authors.lastname: Cavallotti
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Giovenzana
authors.forename: Giovanni
authors.initials: G
authors.lastname: Palmisano
authors.forename: Massimo
authors.initials: M
authors.lastname: Sisti
mesh_terms: D005682:Gadolinium / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D004369:Pentetic Acid / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013696:Temperature
chemical_list: D008024:Ligands; D011725:Pyridines; D004369:Pentetic Acid; D005682:Gadolinium; C023666:pyridine