An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir.
A novel synthetic route towards oseltamivir, an influenza neuraminidase inhibitor, has been achieved employing a cationic iron carbonyl complex, providing an alternate pathway with the potential to access diverse analogues.
Bromfield
Karen M
KM
Organic Chemistry, Department of Chemical and Biological Engineering, Chalmers University of Technology, 41296 Göteborg, Sweden.
Gradén
Henrik
H
Hagberg
Daniel P
DP
Olsson
Thomas
T
Kann
Nina
N
D000998:Antiviral Agents / Q000138:chemical synthesis*; D002248:Carbon Monoxide / Q000737:chemistry; D053138:Cyclohexenes / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D007501:Iron / Q000737:chemistry*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D009942:Organometallic Compounds / Q000737:chemistry*; D053139:Oseltamivir / Q000138:chemical synthesis*
D000998:Antiviral Agents; D053138:Cyclohexenes; D004791:Enzyme Inhibitors; D009942:Organometallic Compounds; D053139:Oseltamivir; D002248:Carbon Monoxide; D007501:Iron; D009439:Neuraminidase