title: Does parosteal liposarcoma differ from other atypical lipomatous tumors/well-differentiated liposarcomas? A molecular cytogenetic study using combined multicolor COBRA-FISH karyotyping and array-based comparative genomic hybridization.
abstract: Parosteal adipocytic tumors of the bone are extremely rare. As a result, (cyto-) genetic data on this entity are essentially lacking. In the literature there is debate as to whether these lesions should be classified according to the criteria used in soft-tissue tumor pathology, or if they should be considered a separate bone tumor entity. Here we present a 68-year-old male patient with a tumor in his right upper leg diagnosed as parosteal atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) on the basis of clinico-radiologic and pathologic findings. Molecular cytogenetic investigations using combined binary ratio labeling fluorescence in situ hybridization and array comparative genomic hybridization showed abnormalities, which are in accordance with the histologic appearance of an atypical lipomatous tumor/well-differentiated liposarcoma. Therefore, on the basis of these molecular cytogenetic investigations, we conclude that parosteal liposarcoma is not a separate entity but should be categorized within the spectrum of soft-tissue ALT/WDLS.
authors.affiliation: Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, Leiden 2300 RC, The Netherlands. k.szuhai@lumc.nl
authors.forename: Károly
authors.initials: K
authors.lastname: Szuhai
authors.forename: Marije
authors.initials: M
authors.lastname: Ijszenga
authors.forename: Jeroen
authors.initials: J
authors.lastname: Knijnenburg
authors.forename: Sander
authors.initials: S
authors.lastname: Dijkstra
authors.forename: Arthur
authors.initials: A
authors.lastname: de Schepper
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Tanke
authors.forename: Pancras C W
authors.initials: PC
authors.lastname: Hogendoorn
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000235:genetics; D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D008067:Lipoma / Q000175:diagnosis* / Q000235:genetics; D008080:Liposarcoma / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D009693:Nucleic Acid Hybridization / Q000379:methods; D010521:Periosteum; D046888:Tissue Array Analysis / Q000379:methods*