title: Imaging features and decision making in retrobulbar neuroendocrine tumours in horses--case report and review of literature.
abstract: A 25-year-old Haflinger gelding was evaluated for chronic-progressive unilateral exophthalmos. Ultrasonographic investigation and magnetic resonance (MR) imaging revealed a retrobulbar space-occupying mass to be the cause of eyeball displacement. Ultrasonographic features were not sufficient to specify the type and extension of the lesion. Magnetic resonance scans, however, clearly displayed an infiltrative intracranial growth pattern but sparing of orbital soft tissues. Based on MR appearance, tentative diagnosis of an orbital soft tissue neoplasia was made and subsequently confirmed by histopathological investigation. The latter revealed a poorly differentiated neuroendocrine tumour. Retrospectively, MR changes resembled those seen with neuroendocrine neoplasms of the human skull. Even if histopathology remains to be elucidated by cytological or histological inspection, MR imaging of equine orbital tumours should provide the criteria necessary for evaluating the therapeutic options and associated prognosis.
authors.affiliation: Institute of Veterinary Pathology, Chair of General Pathology & Neuropathology, Ludwig-Maximilians University, Veterinarstr. 13, D-80539 Munich, Germany. kaspar.matiasek@neuropathologie.de
authors.forename: K
authors.initials: K
authors.lastname: Matiasek
authors.forename: M
authors.initials: M
authors.lastname: Cronau
authors.forename: W
authors.initials: W
authors.lastname: Schmahl
authors.forename: H
authors.initials: H
authors.lastname: Gerhards
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000662:veterinary; D008297:Male; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000662:veterinary*; D009918:Orbital Neoplasms / Q000473:pathology / Q000662:veterinary*; D011379:Prognosis; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000662:veterinary*