Good pregnancy outcome after prenatal exposure to bleomycin, etoposide and cisplatin for ovarian immature teratoma: a case report and literature review.
OBJECTIVE
The administration of bleomycin plus etoposide and cisplatin during pregnancy is rare.


METHODS
We describe a case with good pregnancy outcome after exposure to these chemotherapeutic agents at the third trimester of pregnancy.


CONCLUSIONS
A pregnant woman with stage IIIc immature teratoma underwent surgical staging, and received two cycles of bleomycin, etoposide and cisplatin from the 29th week of pregnancy until delivery. The patient did not have any evidence of recurrence of ovarian cancer for 1.5 years. Her infant did not have any evidence of minor or major malformations, and showed normal neurological development during 1.5 years of follow-up.
Karimi Zarchi
Mojgan
M
Gynecologic Oncology Department, Vali-e-Asr Hospital, Imam Khomeini Hospital Complex, Keshavarz Boulevard, Tehran, Iran. drkarimi2001@yahoo.com
Behtash
Nadereh
N
Modares Gilani
Mitra
M
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000473:pathology; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D013724:Teratoma / Q000188:drug therapy*
D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin