Vitamin E and NF-kappaB activation: a review.
Nuclear factor (NF-kappaB)(1) is a eukaryotic transcription factor that may be activated by oxidative stress. Because of this hypothesis, the effect of vitamin E on NF-kappaB activation has been examined in many studies, using both in vivo and in vitro models. Most of these studies have observed that vitamin E inhibits the activation of NF-kappaB, with the greatest inhibition seen with the succinate form. Vitamin E may be inhibiting NF-kappaB by reducing oxidative stress or through one of its nonantioxidant functions; this is not clear at the present time. It also is not known if the inhibition of NF-kappaB is necessary for any of vitamin E's effects on gene expression and the resulting physiological effects.
Glauert
Howard P
HP
Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40506, USA.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism*; D051381:Rats; D014810:Vitamin E / Q000276:immunology / Q000494:pharmacology
D000975:Antioxidants; D016328:NF-kappa B; D014810:Vitamin E