Anaplastic variant of spermatocytic seminoma.
We report a case of a 56-year-old male with an anaplastic variant of spermatocytic seminoma of the left testis. Grossly, the tumor measured 10 x 7.5 x 6.5 cm and consisted of soft grayish-white tissue, which varied from fleshy to gelatinous with formation of some pseudocysts. Histologically, the tumor was composed of the areas of typical spermatocytic seminoma; however, in some areas, the intermediate and large tumor cells showed prominent nucleoli. In another part of the tumor, we noted anaplastic areas composed of sheets of tumor cells with large vesicular nuclei and prominent nucleoli. Tunical and vascular invasion as well as growth into the epididymis were noted. Immunohistochemically, the tumor cells showed only weak positivity for CD117, the other markers examined were negative.
Dundr
Pavel
P
Institute of Pathology, 1st Faculty of Medicine and General Faculty Hospital, Charles University, Studnickova 2, Prague 128 00, Czech Republic. pdundr@seznam.cz
Pesl
Michael
M
Povýsil
Ctibor
C
Prokopová
Petra
P
Pavlík
Ivan
I
Soukup
Viktor
V
Dvorácek
Jan
J
D000970:Antineoplastic Agents / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D018239:Seminoma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D013736:Testicular Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy
D000970:Antineoplastic Agents; D016190:Carboplatin; D019009:Proto-Oncogene Proteins c-kit