title: Anti-16-kilodalton mycobacterial protein immunoglobulin m levels in healthy but purified protein derivative-reactive children decrease after chemoprophylaxis.
abstract: Serum responses against Mycobacterium tuberculosis HSP16 were determined for children with tuberculosis (TB) and for healthy purified protein derivative (PPD)-positive and PPD-negative children. Immunoglobulin G (IgG) and IgM responses were higher for TB patients than for other groups. After chemotherapy, IgM and IgG responses decreased for TB patients and PPD-positive subjects. Monitoring of anti-M. tuberculosis HSP16 responses could assist in the management of pediatric TB.
authors.affiliation: Dipartimento di Biopatologia e Metodologie Biomediche, Università degli Studi di Palermo, Corso Tukory 211, 90100 Palermo, Italy. sireci@unipa.it
authors.forename: Guido
authors.initials: G
authors.lastname: Sireci
authors.forename: Francesco
authors.initials: F
authors.lastname: Dieli
authors.forename: Diana
authors.initials: D
authors.lastname: Di Liberto
authors.forename: Simona
authors.initials: S
authors.lastname: Buccheri
authors.forename: Marco Pio
authors.initials: MP
authors.lastname: La Manna
authors.forename: Francesco
authors.initials: F
authors.lastname: Scarpa
authors.forename: Pasquale
authors.initials: P
authors.lastname: Macaluso
authors.forename: Amelia
authors.initials: A
authors.lastname: Romano
authors.forename: Lucina
authors.initials: L
authors.lastname: Titone
authors.forename: Paola
authors.initials: P
authors.lastname: Di Carlo
authors.forename: Mahavir
authors.initials: M
authors.lastname: Singh
authors.forename: Jurayi
authors.initials: J
authors.lastname: Ivanyi
authors.forename: Alfredo
authors.initials: A
authors.lastname: Salerno
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000276:immunology*; D018833:Chaperonins / Q000276:immunology*; D018890:Chemoprevention; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000097:blood / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology*; D014376:Tuberculosis / Q000097:blood / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; C431133:Hsp16.3 protein, Mycobacterium tuberculosis; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014373:Tuberculin; D018833:Chaperonins