title: RETRACTED: Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner.
abstract: This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).
  
  This article has been retracted at the request of the editors. Molecular Cell has retracted this article following the results of an investigation carried out by Leiden University Medical Center's Committee of Scientific Integrity, which concluded that unacceptable data manipulation by the last author Maria Fousteri led to breaches of scientific integrity, making these results unreliable. Section 2.2, item 2 of the report indicates several duplications in Figure 4 and that, upon inspection of original data, several proteins stained for by western blotting following immunoprecipitation were incorrectly assigned (Figure 4B). The XPA panel in Figure 4A is a mirrored duplication of an image that was published in Figure 5C of Fousteri et al., 2006 (Mol. Cell 23, 471-482, https://doi.org/10.1016/j.molcel.2006.06.029). Additional details can be found in the redacted version of the investigation report (https://www.lumc.nl/cen/att/80813053317221/1263833/report-lumc-committee-scientific-integrity).
authors.affiliation: Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 RC, The Netherlands.
authors.forename: Jill
authors.initials: J
authors.lastname: Moser
authors.affiliation: Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 RC, The Netherlands.
authors.forename: Hanneke
authors.initials: H
authors.lastname: Kool
authors.affiliation: Genome Damage and Stability Center, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Giakzidis
authors.affiliation: Genome Damage and Stability Center, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK.
authors.forename: Keith
authors.initials: K
authors.lastname: Caldecott
authors.affiliation: Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 RC, The Netherlands. Electronic address: l.mullenders@lumc.nl.
authors.forename: Leon H F
authors.initials: LHF
authors.lastname: Mullenders
authors.affiliation: Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 RC, The Netherlands. Electronic address: m.i.fousteri@lumc.nl.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Fousteri
mesh_terms: D002453:Cell Cycle; D002478:Cells, Cultured; D053904:DNA Breaks, Single-Stranded; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000737:chemistry / Q000378:metabolism*; D004257:DNA Polymerase II / Q000737:chemistry / Q000378:metabolism; D004258:DNA Polymerase III / Q000737:chemistry / Q000378:metabolism; D004260:DNA Repair / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D015536:Down-Regulation; D006801:Humans; D008954:Models, Biological; D046912:Multiprotein Complexes; D018462:Photobiology; D000075223:Poly-ADP-Ribose Binding Proteins; D014466:Ultraviolet Rays / Q000009:adverse effects; D000076105:X-ray Repair Cross Complementing Protein 1; D029867:Xenopus Proteins
chemical_list: D004268:DNA-Binding Proteins; C000607892:LIG1 protein, human; D046912:Multiprotein Complexes; D000075223:Poly-ADP-Ribose Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D029867:Xenopus Proteins; D004257:DNA Polymerase II; D004258:DNA Polymerase III; D011088:DNA Ligases; D000072481:DNA Ligase ATP; C000618816:DNA ligase III alpha protein, Xenopus; C000618817:LIG3 protein, human