Setting the stage for S phase.
In a recent issue of Molecular Cell, Tyagi et al. (2007) show that E2F1, a positive regulator of S phase entry, recruits cofactor HCF-1 and associated hSet1/MLL histone H3 lysine 4 methyltransferase complex, facilitating the activation of genes required for proliferation.
Wilson
Angus C
AC
Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address: wilsoa02@nyu.edu.
D000818:Animals; D050684:E2F Transcription Factors / Q000235:genetics / Q000378:metabolism; D051863:Host Cell Factor C1 / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D016196:S Phase / Q000235:genetics / Q000502:physiology*
D050684:E2F Transcription Factors; C497692:HCFC1 protein, human; D051863:Host Cell Factor C1