[Prevention and treatment of acute diarrhea in infants].
The prognosis of acute diarrhoea in infants is most often satisfactory in industrialized countries. However, it has been estimated that 10 to 15 children die every year in France from acute dehydration due to acute diarrhoea. In spite of an increasing use over the least few years, oral rehydration solutions (ORS) are used in only 70% of infants presenting with acute diarrhoea. The use of homemade ORS, plain water or fizzy drink should be strictly avoided. In case of acute diarrhoea there is no indication to stop breastfeeding or the use of infant formula for more than 4 hours. Lactose intolerance is observed in only 5-10% of infants. Lactose free formulae should only be used in infants with severe, persistent or recurrent diarrhoea. Under 3-4 months of age, infants with severe diarrhoea should receive for a period of 2-4 weeks lactose free protein hydrolysate formulae. Racecadotril is the only drug with anti-diarrheal properties, with a reduction of the stool output of 50%. Oral antibiotics should only be used in case of Shigella infection or in case of bacterial infection with severe sepsis or underlying debilitating disease. Oral Rotavirus vaccine, that is not reimbursed yet in France, has been shown to dramatically reduce the number of severe cases of diarrhoea with dehydration, and has been associated with a striking reduction of both morbidity and mortality, as well as of the number of hospitalisations during periods of epidemics.
Turck
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Unité de gastroentérologie, hépatologie et nutrition, clinique de pédiatrie, hôpital Jeanne-de-Flandre et faculté de médecine, université de Lille-II, 2, avenue Oscar-Lambret, 59037 Lille cedex, France. dturck@chru-lille.fr
D000208:Acute Disease; D000930:Antidiarrheals / Q000627:therapeutic use; D001942:Breast Feeding; D003681:Dehydration / Q000209:etiology / Q000517:prevention & control*; D003968:Diarrhea, Infantile / Q000150:complications / Q000628:therapy*; D005440:Fluid Therapy; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007785:Lactose / Q000008:administration & dosage; D019936:Probiotics / Q000627:therapeutic use; D022243:Rotavirus Vaccines; D015244:Thiorphan / Q000031:analogs & derivatives / Q000627:therapeutic use
D000930:Antidiarrheals; D022243:Rotavirus Vaccines; C049331:racecadotril; D015244:Thiorphan; D007785:Lactose