N2-benzyloxycarbonylguan-9-yl acetic acid derivatives as HIV-1 reverse transcriptase non-nucleoside inhibitors with decreased loss of potency against common drug-resistance mutations.
Adebambo
Kassim F
KF
Chemistry Department, School of Engineering & Physical Sciences, Heriot-Watt University, William H. Perkin Building, Riccarton, Edinburgh EH14 4AS, UK.
Zanoli
Samantha
S
Thomas
Michael G
MG
Cancio
Reynel
R
Howarth
Nicola M
NM
Maga
Giovanni
G
D000085:Acetates / Q000737:chemistry / Q000494:pharmacology*; D024882:Drug Resistance, Viral / Q000235:genetics*; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D007700:Kinetics; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000494:pharmacology*
D000085:Acetates; D018894:Reverse Transcriptase Inhibitors; D006147:Guanine; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase