title: High hepatitis C virus viral load in HIV/hepatitis C virus-co-infected patients: a different influence of protease inhibitor and non-protease inhibitor-based HAART?
abstract: We examined the possible relationships between hepatitis C virus (HCV) viral load and host factors, viral factors, and anti-HIV therapy in 379 HIV/HCV-co-infected patients. Multiple linear regression analysis identified two independent factors associated with higher HCV viral load, HCV genotype 1 or 4 infection and protease inhibitor-based antiretroviral therapy. Antiretroviral therapy in general was independently associated with lower HCV viral load. This suggests that HCV viral load kinetics could differ according to the choice of HAART regimen.
authors.affiliation: Groupe Hospitalier Universitaire Est, Université Paris 6, INSERM U707, Paris, France.
authors.forename: Firouzé
authors.initials: F
authors.lastname: Bani-Sadr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Goderel
authors.forename: Patrice
authors.initials: P
authors.lastname: Morand
authors.forename: Christopher
authors.initials: C
authors.lastname: Payan
authors.forename: Françoise
authors.initials: F
authors.lastname: Lunel
authors.forename: Stanislas
authors.initials: S
authors.lastname: Pol
authors.forename: Christian
authors.initials: C
authors.lastname: Perronne
authors.forename: Fabrice
authors.initials: F
authors.lastname: Carrat
authors.forename: Patrice
authors.initials: P
authors.lastname: Cacoub
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D016174:Hepacivirus / Q000302:isolation & purification*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors