Transcriptional control of oligodendrogenesis.
Oligodendrocytes (OGs) assemble the myelin sheath around axons in the central nervous system. Specification of cells into the OG lineage is largely the result of interplay between bone morphogenetic protein, sonic hedgehog and Notch signaling pathways, which regulate expression of transcription factors (TFs) dictating spatial and temporal aspects of oligodendrogenesis. Many of these TFs and others then direct OG development through to a mature myelinating OG. Here we describe signaling pathways and TFs that are inductive, inhibitory, and/or permissive to OG specification and maturation. We develop a basic transcriptional network and identify similarities and differences between regulation of oligodendrogenesis in the spinal cord and brain.
Nicolay
Danette J
DJ
Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, and Cameco MS Neuroscience Research Center, City Hospital, Saskatoon, Saskatchewan, Canada.
Doucette
J Ronald
JR
Nazarali
Adil J
AJ
D000818:Animals; D001921:Brain / Q000166:cytology*; D002455:Cell Division / Q000502:physiology*; D016922:Cellular Senescence; D006801:Humans; D009457:Neuroglia / Q000166:cytology; D009474:Neurons / Q000166:cytology; D009836:Oligodendroglia / Q000166:cytology* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology*; D013997:Time Factors; D014157:Transcription Factors / Q000502:physiology*
D014157:Transcription Factors