[Average of the PCDFs value in blood in patients with Yusho in the 2001 to 2003 fiscal year and comparison between the clinical features and PCDFs].
BACKGROUND
Kanemi Yusho is the name given to a 1968 food poisoning incident resulting from the ingestion of PCB contaminated rice bran oil that had been used as a heating medium. At the time, victims presented with mainly cutaneous manifestations and various other symptoms such as of the eyes and teeth, general fatigue, headaches, and paresthesia of the extremities. The characteristic symptoms then resolved with time. Yusho patients have been followed from immediately after the incident. Blood levels of dioxins such as PeCDF have been measured for those who wishing to since 2001.


METHODS
The presence or absence of relationships between blood PeCDF level and various examination items/symptoms was investigated in 359 subjects whose blood levels of PCB-related chemical compounds such as PeCDF were measured in the Yusho related examinations between 2001 and 2003. Characteristic symptoms were also compared with the results of examinations done 15 years previously.


CONCLUSIONS
The average blood 2,3,4,7,8-PeCDF level in designated Yusho patients was 177.50 pg/g lipids; showing a markedly higher value than that of the normal control group (15.2 pg/g lipids). As well, the blood PeCDF level was related to PCB level, hexachlorobiphenyl level, urinary sugar, erythrocyte sedimetation rate (ESR) (2-hour), thymol and Na. There were also relationships with cutaneous findings (acneiform eruption and comedones), mucosal findings (oral pigmentation), constipation, numbness in the extremities, body weight loss, and abnormal abdominal ultrasonography. Symptoms seen in the skin and eyes in 2001 and 2003 had decreased compared with those in seen 1988. However, PCB and blood PeCDF levels remained high. Patients are continuing to present with mucosal and subjective symptoms as chronic conditions.
Kanagawa
Yoshiyuki
Y
Department of Planning Information and Management, The University of Tokyo Hospital, Japan. kanagawa-tky@umin.ac.jp
Matsumoto
Shinya
S
Tajima
Bunichi
B
Uenotsuchi
Takeshi
T
Shibata
Satoko
S
Furue
Masutaka
M
Imamura
Tomoaki
T
D001572:Benzofurans / Q000097:blood; D005128:Eye Diseases / Q000209:etiology / Q000473:pathology; D005221:Fatigue / Q000209:etiology; D005506:Food Contamination; D006261:Headache / Q000209:etiology; D006801:Humans; D007564:Japan; D012275:Oryza / Q000506:poisoning*; D010292:Paresthesia / Q000209:etiology; D010938:Plant Oils / Q000506:poisoning*; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000506:poisoning*; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology; D013997:Time Factors; D014076:Tooth Diseases / Q000209:etiology / Q000473:pathology
D001572:Benzofurans; D010938:Plant Oils; D011078:Polychlorinated Biphenyls; C038890:2,3,4,7,8-pentachlorodibenzofuran