[Antiedematous effect of polyosm in rats with freezing lesion of brain].
Effect of the intravenous injection of polyosm (30% solution of polyethylene oxide with a molecular mass of 400, PEO-400) was investigated on Wistar rats with a model of brain edema induced by a freezing lesion in one cerebral hemisphere. The brain edema development was estimated by measuring the active resistance of tissues in the right and left parietal cortex and the content of water in both hemispheres. A course of the intravenous injections of polyosm (1 g/kg of PEO-400 daily during 3 days) after the model lesion onset decreased the initially elevated active resistance in the edematous cerebral tissue and reduced water accumulation in the damaged hemisphere.
Plotnikov
M B
MB
Chernysheva
G A
GA
Smol'iakova
V I
VI
Golubeva
I V
IV
D000818:Animals; D001923:Brain Chemistry; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology; D001930:Brain Injuries / Q000150:complications*; D004234:Diuretics, Osmotic / Q000008:administration & dosage / Q000627:therapeutic use*; D005615:Freezing; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014867:Water / Q000032:analysis
D004234:Diuretics, Osmotic; D014867:Water; D011092:Polyethylene Glycols