Potential management of resistant microbial infections with a novel non-antibiotic: the anti-inflammatory drug diclofenac sodium.
Diclofenac sodium (Dc), an anti-inflammatory agent, has remarkable inhibitory action both against drug-sensitive and drug-resistant clinical isolates of various Gram-positive and Gram-negative bacteria. The aim of this study was to determine the ability of Dc to protect mice from a virulent Salmonella infection. Dc injected at 1.5 microg/g and 3.0 microg/g mouse body weight significantly protected animals from the lethality of Salmonella infection. As was the case for the in vitro interaction, Dc in combination with streptomycin was even more effective. The non-antibiotic drug Dc has potential for the management of problematic antibiotic-resistant bacterial infections.
Dutta
Noton Kumar
NK
Institute of Laboratory Animal Resources, Laboratory Animal Medicine, College of Veterinary Medicine, 85-Dong, 733-Ho, Seoul National University, San 56-1, Sillim 9 Dong, Gwanakgu, Seoul, South Korea.
Annadurai
Subramanian
S
Mazumdar
Kaushiki
K
Dastidar
Sujata G
SG
Kristiansen
Jette E
JE
Molnar
Joseph
J
Martins
Marta
M
Amaral
Leonard
L
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use* / Q000633:toxicity; D014150:Antipsychotic Agents / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D015169:Colony Count, Microbial; D003470:Culture Media; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D004008:Diclofenac / Q000627:therapeutic use* / Q000633:toxicity; D024881:Drug Resistance, Bacterial; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D019779:Salmonella enterica / Q000187:drug effects; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D013307:Streptomycin / Q000494:pharmacology; D014268:Trifluoperazine / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014150:Antipsychotic Agents; D003470:Culture Media; D004269:DNA, Bacterial; D004008:Diclofenac; D014268:Trifluoperazine; D013307:Streptomycin