Reduced TH-1 cytokine release in an adult patient with chronic relapsing Mycobacterium malmoense infection.
An unusual course of infection with Mycobacterium malmoense is described in a patient receiving chronic but mild immunosuppressive therapy for rheumatoid arthritis. Symptoms mimicking Crohn's disease deteriorated under intensified immunosuppression and surgery. Judging from the patient's course under treatment specific for M. malmoense, the gastrointestinal symptoms were rather manifestations of a chronic relapsing mycobacterial infection. Detailed immunological investigation of the patient revealed a severely impaired TH-1 cytokine response as the immunological background for this uncommon course.
Sahrbacher
U
U
Department of Internal Medicine I, University Medical Center, University of Regensburg, Regensburg, Germany.
Naumann
L
L
Reischl
U
U
Schölmerich
J
J
Glück
T
T
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology; D005260:Female; D005759:Gastroenteritis / Q000276:immunology / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007371:Interferon-gamma / Q000378:metabolism; D018655:Lymphocyte Count; D009161:Mycobacterium / Q000145:classification / Q000276:immunology / Q000472:pathogenicity; D012008:Recurrence; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology*
D007166:Immunosuppressive Agents; D007371:Interferon-gamma