title: [Irrational use of drugs as a source of drug - induced diseases].
abstract: The irrational use of medication, by which we understand the administration of drugs for indications where their effectiveness has not been confirmed, the disregard of restrictions and warnings against their use, and the use of drug combinations which do not increase the therapeutic effect but to the contrary increase the risk of adverse drug reactions, is a serious problem encountered in paediatric pharmacotherapy. Each year the centres for monitoring of adverse drug reactions receive many reports, the analysis of which show that the reasons of occurrence of adverse drug reactions after drug administration, are specifically due to irrational use of medications. In order to prevent in an active way the occurrence, of adverse drug reactions following drug administration it is worthwhile to bring to attention the reasons for their occurrence which not infrequently bring about pathological effects. Our work which is based on reports received by the Regional Centre for Adverse Drug Reactions Monitoring in Krakow concerning the occurrence of adverse drug reactions in an attempt to bring to attention in our view important problems in current pharmacotherapy.
authors.affiliation: Zaklad Farmakologii, Klinicznej Katedry Farmakologii, CM, UJ, ul. Sniadeckich 10, 31-531 Krakow, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Woroń
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Porebski
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Kostka-Trabka
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Goszcz
mesh_terms: D000293:Adolescent; D016907:Adverse Drug Reaction Reporting Systems; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004346:Drug Information Services / Q000592:standards*; D004347:Drug Interactions; D004358:Drug Therapy / Q000706:statistics & numerical data; D004363:Drug Utilization / Q000706:statistics & numerical data*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000145:classification*; D006801:Humans; D007223:Infant; D008318:Malpractice / Q000145:classification* / Q000191:economics / Q000706:statistics & numerical data; D008508:Medication Errors / Q000145:classification* / Q000191:economics / Q000706:statistics & numerical data; D010372:Pediatrics / Q000592:standards; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011044:Poland; D019338:Polypharmacy; D012308:Risk Management
chemical_list: D004364:Pharmaceutical Preparations