Modulation of the endocrine and immune systems by well-controlled hyperthermia equipment.
Since high levels of hyperthermia induce immunosuppression to a certain extent (i.e., granulocytosis and lymphocytopenia) in patients, we applied mild hyperthermia in volunteers using equipment enabling well-controlled hyperthermia. Restricted control of rectal temperature at 39.4 (+/- 0.2) degrees C for 30 min was conducted and various parameters of the body were examined. The most prominent change observed during exposure to hyperthermia was elevated levels of pH and PO(2) in the blood, even in the venous blood. A transient elevation of ACTH, cortisol and growth hormone in the blood was also seen during this time. In parallel with this phenomenon, the number of total lymphocytes and those of its subsets (especially CD57(+) or CD56(+) NK cells and NKT cells) increased. More interestingly, the proportion of HLA-DR (MHC class II antigens) increased in NK and NKT cells, and their intensity on the surface of CD20(+) B cells increased. These results suggest that mild hyperthermia is important for modulation of the functions of the circulatory, endocrine and immune systems.
Tomiyama-Miyaji
Chikako
C
Department of Immunology, Niigata University School of Medicine, Niigata, Japan.
Watanabe
Mayumi
M
Ohishi
Takahiko
T
Kanda
Yasuhiro
Y
Kainuma
Eisuke
E
Bakir
Hanaa Y
HY
Shen
Jiwei
J
Ren
Hongwei
H
Inoue
Masashi
M
Tajima
Keiho
K
Bai
Xuefeng
X
Abo
Toru
T
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D001775:Blood Circulation / Q000276:immunology; D001831:Body Temperature / Q000276:immunology; D002478:Cells, Cultured; D005334:Fever / Q000097:blood / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D013006:Growth Hormone / Q000097:blood; D006681:HLA-D Antigens / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D018655:Lymphocyte Count; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism
D006681:HLA-D Antigens; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D006854:Hydrocortisone