Hyperhomocysteinemia and central retinal vein occlusion in Iranian population.
OBJECTIVE
To evaluate total plasma homocysteine level during the acute phase of central retinal vein occlusion (CRVO) in the Iranian population and determine whether hyperhomocysteinemia is also a risk factor for CRVO.


METHODS
Fifty-four patients with recently diagnosed CRVO were studied. Their fasting total plasma homocysteine level was compared with a matched control group of 51 patients evaluated in the same clinic for a non-retinal disease diagnosis.


RESULTS
The mean total plasma homocysteine level was 14.76+/-7.67 micromol/l in cases, and 11.42+/-3.74 micromol/l in control subjects. It showed a significant difference (P=0.005) in mean plasma homocysteine level between cases and control group. Odds ratio of CRVO for individuals with hyperhomocysteinemia was 2.88 (95% CI=1.08-7.71 and P=0.03). The overall multivariable-adjusted odds of CRVO in participants with plasma homocysteine level above 15 micromol/l was 4.71 (95% CI=1.46-15.19 and P=0.009) Hyperhomocysteinemia was not statistically different in each age group (<60 years: 27%, 61-70 years: 33.3%, 71-80 years: 31.6%, >81 years: 33.3%, Chi-square test, P=0.98).


CONCLUSIONS
Elevated total plasma homocysteine level is an independent risk factor for CRVO in Iranian population. In addition to an evaluation of all conventional cardiovascular risk factors, measurement of total homocysteine for evidence of hyperhomocysteinemia may be important in the initial investigation and management of patients with CRVO.
Moghimi
Sasan
S
Farabi Eye Research Center, Department of Ophthalmology, Tehran University of Medical Sciences, Quazvin Square, Tehran 1336616351, Iran. sasanimii@yahoo.com
Najmi
Zahra
Z
Faghihi
Hooshang
H
Karkhaneh
Reza
R
Farahvash
Mohammad Sadegh
MS
Maghsoudipour
Maryam
M
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications*; D007492:Iran; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012170:Retinal Vein Occlusion / Q000097:blood / Q000209:etiology*; D012307:Risk Factors
D006710:Homocysteine