title: Non-tunneled central venous catheters in adult stem cell transplantation recipients: An effective option.
abstract: Stem cell transplantation (SCT) recipients require central venous catheter (CVC) insertion for the administration of chemotherapy, antibiotics and total parenteral nutrition. Traditionally, tunneled CVC have been considered as the golden standard although they require surgery for both insertion and removal. We prospectively evaluated the use of a non-tunneled CVC in 182 consecutive patients who had undergone allogenic or autologous SCT. The median duration of CVC was 4 weeks (range 1-24) with a significant difference between allogenic (8 weeks, range 2-24) and autologous SCT (4 weeks, range 1-24) (p<0.0001). The life expectancy of the CVC was significantly influenced by spontaneous removal, which occurred in 26 patients (13.8%). There was a significant increase of this complication in allogenic SCT (p=0.039). The overall incidence of sepsis was 24.5%, although catheter-related sepsis was microbiologically documented by positive culture of the tip only in 17 cases (9%). Non-tunneled CVC in adult SCT recipients allowed (a) bedside insertion and removal, (b) guidewire replacement for diagnostic or therapeutic purposes (dialysis or pheresis procedures) thus reducing the need for repeated venipunctures. (The Journal of Vascular Access 2001; 2: 168-174).
authors.affiliation: Department of Hematology, Istituto di Semeiotica Medica, Rome - Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cicconi
authors.forename: M
authors.initials: M
authors.lastname: Pittiruti
authors.forename: M
authors.initials: M
authors.lastname: Buononato
authors.forename: N
authors.initials: N
authors.lastname: Piccirillo
authors.forename: F
authors.initials: F
authors.lastname: Sorà
authors.forename: P
authors.initials: P
authors.lastname: Chiusolo
authors.forename: L
authors.initials: L
authors.lastname: Laurenti
authors.forename: G
authors.initials: G
authors.lastname: Leone
authors.forename: S
authors.initials: S
authors.lastname: Sica