A handheld device for potential point-of-care screening of cancer.
A simple handheld device based on the fluorescence analysis of 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide (BMVC) stained cells was established for routine screening and potentially for early detection of cancer cells at extremely low cost. Flow cytometry assay further supported the utility of this simple device, where a preliminary study of tissue biopsy showed highly encouraging results.
Kang
Chi-Chih
CC
Institute of Atomic and Molecular Sciences, Academia Sinica, P.O. Box 23-166, Taipei, Taiwan 106, Republic of China.
Chang
Cheng-Chung
CC
Chang
Ta-Chau
TC
Liao
Li-Jen
LJ
Lou
Pei-Jen
PJ
Xie
Wenjun
W
Yeung
Edward S
ES
D002227:Carbazoles; D002460:Cell Line; D045744:Cell Line, Tumor; D004867:Equipment Design; D005240:Feasibility Studies; D005434:Flow Cytometry; D005456:Fluorescent Dyes; D006801:Humans; D008856:Microscopy, Fluorescence / Q000295:instrumentation / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis*; D019095:Point-of-Care Systems; D011726:Pyridinium Compounds; D012680:Sensitivity and Specificity; D013194:Staining and Labeling
C486012:3,6-bis(1-methyl-4-vinylpyridium)carbazole diiodide; D002227:Carbazoles; D005456:Fluorescent Dyes; D011726:Pyridinium Compounds