Disease modifying approaches for Alzheimer's pathology.
Alzheimer's disease (AD) is the most common age-associated neurodegenerative disease in the world. The major neuropathological features of AD are synaptic loss, neuronal loss, neurofibrillary tangles and the deposition of amyloid-beta (Abeta) as plaques and in cerebral blood vessels. Numerous Abeta targeting therapeutic approaches have been shown to prevent amyloid deposition and resulting in cognitive improvement in transgenic mouse models of AD. Some of these approaches are currently in early clinical trials. It remains to be seen if these approaches will be proven effective in patients. Future anti-AD therapies will likely be multi-modal and individually tailored depending on the patient's immune status, genetic background and their amyloid burden, as determined by imaging studies using Abeta specific labeling ligands. Pre-clinical data suggests that it will be much more feasible to prevent AD related pathology, then to clear existing pathology, making early diagnosis critically important.
Sadowski
Marcin
M
Department of Neurology, New York University School of Medicine, New York, NY 10016, USA.
Wisniewski
Thomas
T
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D006801:Humans; D016874:Neurofibrillary Tangles / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D058225:Plaque, Amyloid / Q000187:drug effects / Q000473:pathology / Q000502:physiology