Oxidation flux change on glomerulus membrane in normal and diabetic nephropathy.
The oxidation process is one of the most important natural processes. Oxidative change in diabetes is believed to be an important process in the pathogenesis. Here, the author determines the oxidation flux change in diabetic nephropathy. A simulation test to determine the oxidation flux change based on nano medicine technique is used. An increase in oxidation flux in the diabetic nephropathy can be derived. Therefore, this work can support the finding that the oxidation flux change plays an important role in the pathogenesis of diabetic nephropathy. Conclusively, the oxidative stress can bring glomerulus thickness, and the thickness glomerulus can further amplify the oxidative injuries.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. wviroj@yahoo.com
D003928:Diabetic Nephropathies / Q000378:metabolism*; D050533:Glomerular Basement Membrane / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D010084:Oxidation-Reduction