title: Synthesis of fluorescent and photoaffinity-labeled derivatives of bisphenol A and their inhibitory activity toward hypoxic expression of erythropoietin.
abstract: Bisphenol A derivatives, possessing a fluorescent dye and a photo-reactive group, were synthesized from bisphenol A, and the inhibitory activity of the derivatives was evaluated against hypoxic response. The synthesized derivatives were found to inhibit the hypoxic expression of erythropoietin in Hep3B cells as well as bisphenol A.
authors.affiliation: Department of Chemistry and Open Research Center on Organic Tool Molecules, School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo 669-1337, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Maezawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsuchikawa
authors.forename: Shigeo
authors.initials: S
authors.lastname: Katsumura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kubo
authors.forename: Susumu
authors.initials: S
authors.lastname: Imaoka
mesh_terms: D001559:Benzhydryl Compounds; D015687:Cell Hypoxia; D004921:Erythropoietin / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D006801:Humans; D010636:Phenols / Q000737:chemistry*; D019920:Photoaffinity Labels / Q000138:chemical synthesis*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004921:Erythropoietin; D005456:Fluorescent Dyes; D010636:Phenols; D019920:Photoaffinity Labels; C006780:bisphenol A; D000098826:Bisphenol A Compounds