Molecular basis for the unique specificity of TRAF6.
Tumor necrosis factor (TNF) receptor (TNFR) associated factor 6 (TRAF6) is a unique member of the TRAF family of adaptor proteins that is involved in both the TNF receptor superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily signal transduction pathways. The ability to mediate signals from both families of receptors implicates TRAF6 as an important regulator of a diverse range of physiological processes such as innate and adaptive immunity, bone metabolism, and the development of lymph nodes, mammary glands, skin, and the central nervous system. This chapter will highlight the structural and biochemical studies of TRAF6 in receptor interactions and discuss the potential for peptidomimetic drug application based on TRAF6 receptor binding motif.
Chung
Jee Y
JY
Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.
Lu
Miao
M
Yin
Qian
Q
Lin
Su-Chang
SC
Wu
Hao
H
D000818:Animals; D006801:Humans; D048029:TNF Receptor-Associated Factor 6 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
D048029:TNF Receptor-Associated Factor 6