Molecular targets for the treatment of testicular germ cell tumors.
In the last decade novel therapeutic approaches for the treatment of cancer have been proposed: inhibitors of serine/threonine and tyrosine kinases, angiogenesis inhibitors, gene therapy approaches and others. In some cases the clinical trials have confirmed the efficacy of these approaches. Here, we will review the discovered molecular targets for the treatment of testicular germ cell tumors.
Chieffi
Paolo
P
Dipartimento di Medicina Sperimentale, II Università di Napoli, Napoli, Italy. Paolo.Chieffi@unina2.it
D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D064127:Aurora Kinases; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D015316:Genetic Therapy; D006801:Humans; D008297:Male; D051379:Mice; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases