title: Identifying unmet therapeutic domains in schizophrenia patients: the early contributions of Wayne Fenton from Chestnut Lodge.
abstract: Wayne Fenton, MD, died on September 3, 2006, while giving emergency clinical care. His leadership at National Institute of Mental Health provided a framework for therapeutic discovery. He crafted a new approach to psychosis based on poor functional outcomes and the psychopathology domains underlying long-term morbidity. His research and clinical observations during his career at the Chestnut Lodge clarified the unmet therapeutic needs in schizophrenia and provided the foundation for his vision. The results have radically changed the paradigm for discovery with emphasis on impaired cognition and negative symptom psychopathology.
authors.affiliation: Department of Psychiatry, Yale University, USA.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: McGlashan
authors.forename: William T
authors.initials: WT
authors.lastname: Carpenter
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D003072:Cognition Disorders / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D049674:History, 21st Century; D006778:Hospitals, Psychiatric / Q000266:history; D006801:Humans; D008396:Maryland; D009315:National Institute of Mental Health (U.S.) / Q000266:history; D011570:Psychiatry / Q000266:history; D011613:Psychotherapy / Q000379:methods; D012559:Schizophrenia / Q000188:drug therapy / Q000628:therapy*; D012565:Schizophrenic Psychology; D014481:United States
chemical_list: D014150:Antipsychotic Agents