title: Regulating B-cell activation and survival in response to TLR signals.
abstract: Following encounters with microbes, cellular activation programs that involve the control of proliferation and survival are initiated in follicular B cells either via the B-cell receptor in a specific antigen-defined manner, or through Toll-like receptors (TLRs) that recognize specific microbial products. This review summarizes and discusses recent findings that shed light on how the nuclear factor kappaB pathway controls and coordinates B-cell division and survival following TLR4 engagement.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. geron@wehi.edu.au
authors.forename: Steve
authors.initials: S
authors.lastname: Gerondakis
authors.forename: Raelene J
authors.initials: RJ
authors.lastname: Grumont
authors.forename: Ashish
authors.initials: A
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000201:enzymology / Q000276:immunology*; D002470:Cell Survival; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D016328:NF-kappa B; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D016328:NF-kappa B; D051193:Toll-Like Receptors