title: Dietary Selenium for the counteraction of oxidative damage: fortified foods or supplements?
abstract: Since any significant modification in the Se status, leading to changes in the activity of the seleno-enzymes, may have important consequences on the susceptibility of tissues to oxidative stress, considerable efforts have been made upon increasing Se dietary intake. In this respect, an important debate is still open about the bioavailability and the effectiveness of Se, and more generally nutrients, in supplements compared with foods. Using male Wistar rats, we have compared the effectiveness of two different diets in which an adequate Se content (0.1 mg/kg) was achieved by adding the element as sodium selenite or as component of a lyophilized Se-enriched food, in the counteraction of an oxidative stress induced by intraperitoneal administration of adriamycin. Both Se-enriched diets were able to reduce the consequences of the oxidative stress in liver, mainly by increasing glutathione peroxidase activity. This increase was more evident in rats fed on the diet enriched with the lyophilized food, probably due to the different chemical forms of Se, or to other components of the food itself. Although further studies are needed, data herein presented may contribute to the characterization of the effectiveness of Se from different sources, foods or supplements, in the light of dietary advice to the population concerning improvement of Se intake.
authors.affiliation: Research Centre on Nutrition and Vitaminology, Department of Biochemistry "G. Moruzzi", University of Bologna, via Irnerio, 48 - 40126 Bologna, Italy. alessandra.bordoni@unibo.it
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bordoni
authors.forename: Francesca
authors.initials: F
authors.lastname: Danesi
authors.forename: Marco
authors.initials: M
authors.lastname: Malaguti
authors.forename: Mattia
authors.initials: M
authors.lastname: Di Nunzio
authors.forename: Francesca
authors.initials: F
authors.lastname: Pasqui
authors.forename: Magda
authors.initials: M
authors.lastname: Maranesi
authors.forename: Pier
authors.initials: P
authors.lastname: Luigi Biagi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000032:analysis; D001682:Biological Availability; D015415:Biomarkers / Q000097:blood; D019587:Dietary Supplements; D005227:Fatty Acids / Q000032:analysis; D005527:Food, Fortified; D005978:Glutathione / Q000032:analysis; D005979:Glutathione Peroxidase / Q000032:analysis / Q000097:blood; D008055:Lipids / Q000032:analysis / Q000737:chemistry; D008099:Liver / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000097:blood; D012643:Selenium / Q000008:administration & dosage* / Q000097:blood; D018038:Sodium Selenite / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005227:Fatty Acids; D008055:Lipids; D017382:Reactive Oxygen Species; D005979:Glutathione Peroxidase; D005978:Glutathione; D012643:Selenium; D018038:Sodium Selenite