title: Preclinical cognitive decline and subsequent sleep disturbance in older women.
abstract: OBJECTIVE
  To determine whether longitudinal cognitive decline is associated with increased risk of sleep disturbance in older, nondemented, community-dwelling women.
  
  
  METHODS
  We studied 2,474 women (mean age 68.9 years) who were part of a prospective study started in 1986; women with baseline or follow-up evidence of possible dementia were excluded. Cognitive data were gathered over 15 years for modified Mini-Mental State Examination (mMMSE) and 13 years for Trails B; cognitive decline was defined as declining >1.5 SDs on the mMMSE (> or =3 points) or Trails B (>92 seconds). Sleep disturbance was measured objectively using actigraphy (Sleepwatch-O, Ambulatory Monitoring) at the 15-year follow-up visit; measures included total sleep hours, sleep efficiency, sleep latency, napping, and time awake after sleep onset (WASO).
  
  
  RESULTS
  During follow-up, 11% of women declined on mMMSE and 15% on Trails B. Cognitive decliners were more likely than non-decliners to experience sleep disturbance at follow-up on most measures. For women who declined on mMMSE, adjusted ORs (aOR) (95% CI) were 1.71 (1.24, 2.37) for sleep efficiency <70%, 1.57 (1.12, 2.21) for sleep latency > or =1 hour, and 1.43 (1.07, 1.92) for WASO > or =90 minutes. Results were similar for women who declined on Trails B; in addition, these women were more likely to nap >2 hours per day (aOR: 1.73; 95% CI: 1.28, 2.33). Cognitive decline on either test was not associated with total sleep time.
  
  
  CONCLUSIONS
  Cognitive decline is associated with sleep disturbance in nondemented community-dwelling elderly women.
authors.affiliation: Department of Psychiatry, University of California, San Francisco, and the San Francisco VA Medical Center, San Francisco, CA, USA. Kristine.Yaffe@ucsf.edu
authors.forename: K
authors.initials: K
authors.lastname: Yaffe
authors.forename: T
authors.initials: T
authors.lastname: Blackwell
authors.forename: D E
authors.initials: DE
authors.lastname: Barnes
authors.forename: S
authors.initials: S
authors.lastname: Ancoli-Israel
authors.forename: K L
authors.initials: KL
authors.lastname: Stone
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008609:Mental Status Schedule; D011446:Prospective Studies; D012893:Sleep Wake Disorders / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology