Calcium signaling: pyruvate and CRAC meet at the crossroads.
Receptor-evoked Ca(2+) influx is mediated by store-operated Ca(2+) channels, such as the CRAC channel, which mediates the I(crac) current. Recent work reveals that pyruvate, the precursor substrate for the Krebs cycle, regulates I(crac) to prolong Ca(2+) influx into the cell, thereby coupling oxidation of glucose and its own metabolism in the mitochondria to Ca(2+) influx by the CRAC channel.
Muallem
Shmuel
S
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Shmuel.muallem@utsouthwestern.edu
D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D019069:Cell Respiration / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D019289:Pyruvic Acid / Q000378:metabolism*
D015220:Calcium Channels; D019289:Pyruvic Acid; D005947:Glucose; D002118:Calcium