The X family portrait: structural insights into biological functions of X family polymerases.
The mammalian family X DNA polymerases (DNA polymerases beta, lambda, mu, and TdT) contribute to base excision repair and double-strand break repair by virtue of their ability to fill short gaps in DNA. Structural information now exists for all four of these enzymes, making this the first mammalian polymerase family whose structural portrait is complete. Here we consider how distinctive structural features of these enzymes contribute to their biological functions in vivo.
Moon
Andrea F
AF
Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, United States.
Garcia-Diaz
Miguel
M
Batra
Vinod K
VK
Beard
William A
WA
Bebenek
Katarzyna
K
Kunkel
Thomas A
TA
Wilson
Samuel H
SH
Pedersen
Lars C
LC
D000595:Amino Acid Sequence; D000818:Animals; D002384:Catalysis; D004260:DNA Repair; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid
D004259:DNA-Directed DNA Polymerase