Breakthrough invasive pulmonary aspergillosis despite empirical voriconazole therapy for febrile neutropenia: case report and review of the literature.
We report the development of invasive pulmonary aspergillosis in a patient treated for acute myeloid leukaemia during empirical voriconazole therapy for febrile neutropenia. The patient failed to respond to the institution of salvage combination therapy with amphotericin B and voriconazole, but survived after adjunctive surgical resection.
Meyer
Marianne
M
Division of Pulmonary Medicine, Geneva University Hospitals, Geneva, Switzerland. marianne.meyer@hcuge.ch
Waldvogel
Sophie
S
Chalandon
Yves
Y
Bongiovanni
Massimo
M
Pache
Jean-Claude
JC
Van Delden
Christian
C
D000208:Acute Disease; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy / Q000601:surgery*; D025141:Drug Resistance, Fungal / Q000187:drug effects*; D005334:Fever / Q000382:microbiology; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000382:microbiology; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole