title: Fertility preservation in female cancer survivors.
abstract: The advancement of cancer therapies over the last few decades has significantly improved long-term survival of cancer patients, especially children and adolescents. As many of the therapeutic agents used are highly cytotoxic, cancer survivors have to pay the price of enduring various immediate and long-term side-effects. Unfortunately, gonadal failure and infertility are among the most common long-term side-effects, resulting in distress, lowered self-esteem and quality of life. Three modalities of fertility preservation can be offered to female patients prior to commencing their cancer treatment: embryo, oocyte and ovarian tissue cryopreservation. This paper reviews the outcomes for female patients who underwent fertility preservation in University College Hospital between 1995 and 2005, and post-therapeutic use of their frozen specimens. In addition, the effects of cytotoxic agents on fertility and ovarian function, and the range of fertility preservation available for female cancer sufferers are also discussed.
authors.affiliation: Royal Free and University College Medical School, London, UK. jaskerwei@gmail.com
authors.forename: J K W
authors.initials: JK
authors.lastname: Yap
authors.forename: M
authors.initials: M
authors.lastname: Davies
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D015925:Cryopreservation / Q000379:methods*; D004622:Embryo, Mammalian; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D009369:Neoplasms / Q000150:complications / Q000628:therapy; D009865:Oocytes; D010053:Ovary; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents