Misoprostol to induce labour: a review of its use in a NSW hospital.
BACKGROUND
Induction of labour (IOL) is a common procedure in maternity care. Misoprostol is a prostaglandin E(1) analogue that is effective, cheap and easily stored but not licensed for this use in Australia. Despite evidence supporting the use of misoprostol for IOL, few Australian maternity units use it.


OBJECTIVE
To review the outcomes of women who received vaginal misoprostol for IOL.


METHODS
A retrospective review of all births induced with vaginal misoprostol from July 1998 to October 2005 at one hospital in New South Wales. Women who had an IOL for multiple pregnancy, known fetal death or congenital abnormality were excluded.


RESULTS
In total, 1998 women with a normal, viable, single fetus received vaginal misoprostol for IOL. More than half (57%) of women did not require augmentation during labour. More than one third (37%) had epidural analgesia, 25% had an emergency Caesarean section, 7% had a post-partum haemorrhage and 16% of babies were admitted to the special care nursery. Uterine rupture occurred in two women, one of whom had a history of uterine surgery. There were two neonatal deaths, both because of Group B Streptococcus infection.


CONCLUSIONS
In this cohort of women, misoprostol was an effective and safe agent to induce labour. Recent legal concerns at this hospital make its future use in normal clinical practice unlikely.
Roberts
Lynne M
LM
Division of Women's and Children's Health, St George Hospital, Kogarah, NSW, Australia. lynne.roberts@sesiahs.health.nsw.gov.au
Homer
Caroline S E
CS
Davis
Gregory K
GK
Miller
Trent D
TD
D000328:Adult; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000009:adverse effects; D016595:Misoprostol; D009517:New South Wales; D010120:Oxytocics; D010298:Parity; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D014597:Uterine Rupture / Q000209:etiology
D010120:Oxytocics; D016595:Misoprostol