[Rescue therapy in lupus nephritis patients with mycophenolate mofetil].
BACKGROUND
Long term cyclophosfamide combinated steroids therapy improves renal survival in patients with Proliferate Lupus Nephritis, with considerable toxic effects. In lately years MMF, a immune suppressor used in transplant, seems to be effective in selected cases of Lupus Nephritis.


METHODS
We will describe six patients with Lupus Nephritis class IV and V (OMS Classification), that what different causes they must be treated with MMF like rescue drug. This stabilizes the renal function, controls LES activity and allows reductions or end of corticoids.


RESULTS
In tree cases we achievement total remission, two show partial remission and we had a fail because plaquetopenia and severe leucopenia with serious sepsis to give rise to neumopaty; this patient broke off the treatment. One presented Zoster Herpes that was treated with Aciclovir and temporary treatment break off.


CONCLUSIONS
MMF was effective to get remission in NL and maintain inactive LES, so it must to be considering as rescue therapy, or maintenance treatment after cyclosphosfamide induction. In patients where fertility is important must be considering like elective drug. Is necessary long time patients follow up to asses' effectiveness in renal survival, like cyclophosfamide.
Pretini
Viviana B
VB
Servicio de Nefrología y Medio Interno del Hospital Nacional de Clinicas, Universidad Nacional de Córdoba.
Avila López
Gastón E
GE
Sesín
Ana M
AM
Dotto
Beatriz H
BH
Sanchez Freytes
Marcelo
M
Sesín
Jorge
J
Vergottini
Juan C
JC
D000328:Adult; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D005260:Female; D006417:Hematuria / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008181:Lupus Nephritis / Q000145:classification / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D011507:Proteinuria / Q000188:drug therapy; D012074:Remission Induction; D016879:Salvage Therapy / Q000379:methods*; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D003404:Creatinine; D009173:Mycophenolic Acid