COMT Val158Met moderation of stress-induced psychosis.
BACKGROUND
Exposure to stressful life events increases the risk of developing a psychotic disorder. Moreover, increased reactivity to stress seems to represent part of the vulnerability for psychosis. This study aimed to investigate whether a functional polymorphism in the catechol-O-methyltransferase (COMT Val(158)Met) gene moderates the psychosis-inducing effects of stress.


METHODS
A semi-experimental stress exposure paradigm was used in a sample of 306 genotyped young men (aged 19-24 years), in whom measures of psychotic symptoms were obtained at recruitment in the Greek army (exposed condition) and again after 18 months of military training (unexposed condition).


RESULTS
Stress exposure at army induction was associated with an increased level of psychotic symptoms. In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stress on the psychosis outcome than those with the Met/Met genotype (test for interaction: chi2 = 5.02, df = 1, p = 0.025).


CONCLUSIONS
The COMT Val(158)Met genotype may moderate the effect of stress on psychotic symptoms.
Stefanis
Nicholas C
NC
Division of Psychological Medicine, Institute of Psychiatry, London, UK.
Henquet
Cécile
C
Avramopoulos
Dimitrios
D
Smyrnis
Nikolaos
N
Evdokimidis
Ioannis
I
Myin-Germeys
Inez
I
Stefanis
Costas N
CN
Van Os
Jim
J
D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease / Q000235:genetics* / Q000523:psychology; D005838:Genotype; D006115:Greece; D006801:Humans; D008016:Life Change Events; D008297:Male; D008889:Military Personnel / Q000523:psychology; D016273:Occupational Exposure; D011110:Polymorphism, Genetic; D011618:Psychotic Disorders / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology; D013315:Stress, Psychological / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology
D002394:Catechol O-Methyltransferase