title: Synthesis, analgesic and anti-inflammatory activity of 4-(2-phenoxyphenyl)semicarbazones.
abstract: A series of 4-(2-phenoxyphenyl)semicarbazones was synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds (e. g. 10h, 10i, and 11i) were found to be more potent than the reference drug mefenamic acid in the formalin test. Based on the results of an anti-inflammatory study, 1-(1-(2,5-dimethoxyphenyl)ethylidene)-4-(2-phenoxyphenyl)semicarbazide 11i was the most active compound.
authors.affiliation: Department of Chemistry, University of Guilan, Rasht, Iran.
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Rineh
authors.forename: Nosratollah
authors.initials: N
authors.lastname: Mahmoodi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
authors.forename: Alireza
authors.initials: A
authors.lastname: Foroumadi
authors.forename: Maedeh
authors.initials: M
authors.lastname: Sorkhi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D012664:Semicarbazones