Lipofuscin, homocysteine and tissue polypeptide specific antigen in gestational hypertension.
OBJECTIVE
The aim of this study were to assess the levels of lipofuscin (parameter of oxidative stress), homocysteine (as a marker of vascular injury) and tissue specific antigen - TPS - (as a marker of cell proliferation) in relation to arterial pressure of pregnant woman.


METHODS
Healthy pregnant women (n=18), women with mild 140/90=< RR<160/100 (n=19), and severe 160/100=<RR (n=23) gestational hypertension were enrolled. Lipofuscin has been determined by fluorescence spectroscopy, homocysteine by MEIA commercial kit from Abbott IMx, TPS by EIA method using kit from BEKI.


RESULTS
Mean duration of gestation was 34+/-5 weeks, and there were no differences between groups. Serum lipofuscin levels in mild form of pregnancy-induced hypertension were decreased comparing to normal pregnancy. Homocysteine levels were decreased and TPS levels increased in both mild and severe gestational hypertension.


CONCLUSIONS
Our results suggest overestimation of the role of oxidative stress and hyperhomocysteinemia in gestational hypertension.
Partyka
Robert
R
Department of Clinical Immunodiagnostics, Medical University of Silesia, Katowice, Poland.
Chmiel
B
B
Sikora
Jerzy
J
Grabowska
T
T
Wróbel
B
B
Praisner
A
A
Pióro
A
A
Jałowieicki
P
P
Kokocinska
Danuta
D
D001794:Blood Pressure; D003404:Creatinine / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D008062:Lipofuscin / Q000097:blood*; D018384:Oxidative Stress; D010455:Peptides / Q000097:blood*; D011247:Pregnancy
D008062:Lipofuscin; D010455:Peptides; C089984:tissue polypeptide specific antigen; D006710:Homocysteine; D003404:Creatinine