[Ethymisole: reassessing and old drug].
Ethymisole, or 4,5-di(N-methylcarbamoyl)-1-ethyl-imidazole, is a cognitive enhancer and nootropic drug, the molecular target of which is a multifunctional protein kinase C K2 (casein kinase II). New data about signal pathways and protein substrates of CK2 have been obtained due to research effort of many laboratories. The paper presents a historical sketch of molecular investigations underlying memory enhancer effects of ethymisole; this and the other pharmacological effects of ethymisole are considered in the light of new data.
Reĭkhardt
B A
BA
Sapronov
N S
NS
D000818:Animals; D047390:Casein Kinase II / Q000235:genetics / Q000378:metabolism*; D005042:Etimizol / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D018697:Nootropic Agents / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D018696:Neuroprotective Agents; D018697:Nootropic Agents; D047390:Casein Kinase II; D005042:Etimizol