Iodide mumps after contrast media imaging: a rare adverse effect to iodine.
BACKGROUND
Exposure to iodinated contrast media may elicit a variety of adverse reactions. Anaphylactoid and delayed cell-mediated unwanted effects are common; rare adverse reactions include iodine-related sialadenopathy, iododerma, and acneiform eruptions.


OBJECTIVE
To describe the occurrence of iodide mumps in a patient examined using contrast-enhanced computed tomography and to outline differential diagnoses.


METHODS
A detailed diagnostic approach, including histologic analysis, skin tests, controlled reexposure, efficacy of premedication, and imaging studies, is presented. The findings unique to this reaction and differential diagnoses are highlighted.


RESULTS
While undergoing repeated contrast-enhanced computed tomography a patient developed recurrent swellings of the sublingual glands, identified as iodide mumps. These swellings resolved within a few days. Imaging studies and histologic analysis showed distinct patterns without inflammation. The important role of iodine in this adverse reaction is demonstrated.


CONCLUSIONS
Iodine from iodinated contrast media may rarely elicit noninflammatory edema of the salivary glands. The reaction should be differentiated from other swellings in the head and neck area.
Gilgen-Anner
Yael
Y
Department of ENT, University Hospital Basel, Basel, Switzerland.
Heim
Markus
M
Ledermann
Hans-Peter
HP
Bircher
Andreas J
AJ
D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004487:Edema / Q000473:pathology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D007455:Iodine / Q000009:adverse effects*; D017613:Iodine Compounds / Q000009:adverse effects; D007472:Iohexol / Q000009:adverse effects / Q000031:analogs & derivatives; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D009333:Neck / Q000473:pathology; D010306:Parotid Gland / Q000473:pathology; D011193:Potassium Iodide / Q000009:adverse effects; D013363:Submandibular Gland / Q000473:pathology
D003287:Contrast Media; D017613:Iodine Compounds; D007483:Iothalamic Acid; D011193:Potassium Iodide; D007472:Iohexol; C038192:iopromide; D007455:Iodine; C002587:ioxitalamic acid