Research on mitochondria and aging, 2006-2007.
This review focuses on some of the 'hot topics' that fall under the general heading 'mitochondria and aging'. For each selected topic, we highlight recent publications that have either addressed specific problems within the field or presented novel findings of interest regarding the links between mitochondria and aging. These include studies on the structure of complex I and the mechanisms of superoxide production by this complex; work showing a novel site of hydrogen peroxide production within mitochondria that is modulated by caloric restriction; explorations of the relationship between the rate of evolution of mitochondrial DNA and lifespan; a demonstration that mitochondrial DNA mutations do not limit lifespan in mice; and investigations of the effects of mitochondrial fission on aging. We also list other relevant articles of interest and suggest some key challenges for the field in the near future.
Lambert
Adrian J
AJ
Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge, UK.
Brand
Martin D
MD
D000375:Aging / Q000502:physiology*; D000818:Animals; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism; D042967:Electron Transport Complex I / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D008136:Longevity / Q000502:physiology; D051379:Mice; D008928:Mitochondria / Q000502:physiology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*
D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species; D042967:Electron Transport Complex I