Blood pressure and kidney size in term newborns with intrauterine growth restriction.
OBJECTIVE
Low birth weight is associated with higher blood pressure in childhood and adulthood. The aim of this study was to investigate the influence of intrauterine growth restriction (IUGR) on newborn systolic blood pressure (SBP).


METHODS
Prospective comparative study at Neonatal and Intensive in Clinical Pediatrics Division, Maternity Hospital in Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo.


METHODS
35 newborns with IUGR and 35 without IUGR were compared. Healthy term newborns without malformations, with Apgar score at fifth minute > 6 were included. Birth weight, kidney weight/birth weight ratio, kidney weight (ultrasound scan), plasma renin activity (PRA) and SBP evolution were analyzed during the first month of life (on 1st, 3rd, 7th and 30th days).


RESULTS
SBP evolution, kidney weight/birth weight ratio and PRA did not differ between the two groups. In newborns with IUGR, SBP presented positive correlations with birth weight (r = 0.387 p = 0.026) and BMI (r = 0.412 p = 0.017) on the 7th day of life. Positive correlations with birth weight (r = 0.440 p = 0.01) and birth length (r = 0.386 p = 0.026) were also seen on the 30th day. There was an inverse correlation on the 7th day between SBP and kidney weight/birth weight ratio (r = -0.420 p = 0.014), but this did not persist to the end of the month.


CONCLUSIONS
IUGR seems not to have any influence on SBP, PRA or kidney weight among term newborns during their first month of life.
Matsuoka
Oscar Tadashi
OT
Neonadal and Clinical Pediatrics Division, Children's Institute, Nursery Annex of the Maternity of the Clinics Hospital of the São Paulo, University Medical School, São Paulo, Brazil. oscar_tadashi@yahoo.com.br
Shibao
Simone
S
Leone
Cléa Rodrigues
CR
D001794:Blood Pressure / Q000502:physiology*; D004812:Epidemiologic Methods; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D006801:Humans; D007230:Infant, Low Birth Weight / Q000502:physiology; D007231:Infant, Newborn; D007668:Kidney / Q000033:anatomy & histology*; D008297:Male; D009929:Organ Size; D012083:Renin / Q000097:blood; D013599:Systole / Q000502:physiology; D047929:Term Birth; D013997:Time Factors
D012083:Renin