title: [Adult onset Still's disease: about 11 cases].
abstract: BACKGROUND
  Adult onset Still's disease (AOS) is an inflammatory disorder which associates variable articular and systemic manifestations. Despite a better knowledge of its biological and clinical particularities; the pathogeny of this disease remains unknown. The aim of this study is to analyze the epidemiological, clinical, biological and, outcome characteristics of AOS.
  
  
  METHODS
  It is a retrospective study about 11 cases of AOS hospitalized over a 24-year-period (1982-2005) at The Rheumatology Department of Charles Nicolle's Hospital of Tunis. All patients responded to the Yamaguchi criteria.
  
  
  RESULTS
  Mean age was 35.4 years [20y-70y] with a sex-ratio of 0.57. Fever and articular involvement were the most frequent signs. Cutaneous symptoms were present in 6 patients. Three of our patients developed destructive arthritis. Renal amyloidosis, a rare complication of AOS, has been noted in one case.
  
  
  CONCLUSIONS
  AOS is an unfrequent disorder characterized by its diagnosis and treatment difficulties. Recent advances in immunotherapy may better the management of AOS.
authors.affiliation: Service de rhumatologie--Hôpital Charles Nicolle, Tunis, Tunisie.
authors.forename: Leila
authors.initials: L
authors.lastname: Cheikhrouhou Abdelmoula
authors.forename: Raoudha
authors.initials: R
authors.lastname: Tekaya
authors.forename: Chiraz
authors.initials: C
authors.lastname: Ben Hadj Yahia
authors.forename: Lilia
authors.initials: L
authors.lastname: Chaabouni
authors.forename: Rafik
authors.initials: R
authors.lastname: Zouari
mesh_terms: D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000453:epidemiology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001168:Arthritis / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005334:Fever / Q000503:physiopathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012189:Retrospective Studies; D016706:Still's Disease, Adult-Onset / Q000453:epidemiology* / Q000503:physiopathology; D016896:Treatment Outcome; D014416:Tunisia / Q000453:epidemiology
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D011241:Prednisone