Paraganglioma: report of a rare case with ovarian involvement.
We report a well-documented case of paraganglioma involving right ovary, which was initially misdiagnosed as a Sertoli-Leydig cell tumor and recurred one year later. The right ovarian tumor measured 105x90x60 mm and was associated to a subdiaphragmatic tumor measuring 80x60x35 mm, a peritoneal and a preureteral nodules measuring 10 mm either. Microscopically, tumor cells were arranged in trabeculae and cords separated by a delicate stroma. Their cytoplasm was abundant granular and eosinophilic. Their nuclei were enlarged and regular in size with coarse chromatine and a large nucleolus. The tumor expressed neuroendocrine markers (chromogranin, synaptophysin) epithelial membrane antigen and focally cytokeratin 7 and E-cadherin. Pathological ovarian paraganglioma diagnosis could be difficult but one should be aware of its bona fide existence. The clinical course is favourable in most of the cases.
Bacha
D
D
Pathology Department, Salah Azaiez Institute, Bab Saadoun, Tunis, Tunisia. dhouhabacha@voila.fr
Mrad
K
K
Dhouib
R
R
Driss
M
M
Abbes
I
I
Sassi
S
S
Ben Romdhane
K
K
D000328:Adult; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology*; D010235:Paraganglioma / Q000473:pathology*