title: Total oxidant/antioxidant status in jaundiced newborns before and after phototherapy.
abstract: OBJECTIVE
  To assess the effect of phototherapy on serum oxidant and antioxidant status in hyperbilirubinemic full-term newborns.
  
  
  METHODS
  Thirty-four full-term infants from 3 to 10 days of age exposed to phototherapy were studied. The serum antioxidant status was assessed by measuring the total antioxidant capacity (TAC) and individual antioxidant components: vitamin C, uric acid, albumin, thiol contents and total bilirubin. The oxidant status was assessed by determining the total oxidant status (TOS), oxidative stress index (OSI) and individual oxidant components: malondialdehyde (MDA), and lipid hydroperoxide levels.
  
  
  RESULTS
  Vitamin C, uric acid, total bilirubin and MDA concentration were significantly lower, whereas serum TOS, lipid hydroperoxide and OSI levels were significantly higher after phototherapy (p < 0.05). There were significant positive correlations between serum total bilirubin and MDA (r = 0.434, p = 0.001).
  
  
  CONCLUSIONS
  Although the MDA level was reduced after phototherapy, phototherapy has a negative impact on numerous parts of the oxidant/antioxidant defense system in jaundiced full-term newborns, exposing them to potential oxidative stress.
authors.affiliation: Children's Hospital at Sanliurfa, Sanliurfa, Turkey. ayciceka@hotmail.com
authors.forename: Ali
authors.initials: A
authors.lastname: Aycicek
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
mesh_terms: D001205:Ascorbic Acid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood* / Q000628:therapy; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D010789:Phototherapy / Q000009:adverse effects*; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D008054:Lipid Peroxides; D014527:Uric Acid; D008315:Malondialdehyde; D001205:Ascorbic Acid