Characterization and heritability of obesity and associated risk factors in vervet monkeys.
OBJECTIVE
The objective was to determine the prevalence and heritability of obesity and risk factors associated with metabolic syndrome (MS) in a pedigreed colony of vervet monkeys.


METHODS
A cross-sectional study of plasma lipid and lipoprotein concentrations, glycemic indices, and morphometric measures with heritability calculated from pedigree analysis. A selected population of females was additionally assessed for insulin sensitivity and glucose tolerance.


METHODS
All mature male (n=98), pregnant (n=40) and non-pregnant female (n=157) vervet monkeys were included in the study. Seven non-pregnant females were selected on the basis of high or average glycated hemoglobin (GHb) for further characterization of carbohydrate metabolism.


METHODS
Morphometric measurements included body weight, length, waist circumference, and calculated BMI. Plasma lipids [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C)] and glycemic measures (fasting blood glucose, insulin, and GHb) were measured. A homeostasis model assessment index was further reported. Glucose tolerance testing and hyperinsulinemic-euglycemic clamps were performed on 7 selected females.


CONCLUSIONS
Vervet monkeys demonstrate obesity, insulin resistance, and associated changes in plasma lipids even while consuming a low-fat (chow) diet. Furthermore, these parameters are heritable. Females are at particular risk for central obesity and an unfavorable lipid profile (higher TG, TC, and no estrogen-related increase in HDL-C). Selection of females by elevated GHb indicated impaired glucose tolerance and was associated with central obesity. This colony provides a unique opportunity to study the development of obesity-related disorders, including both genetic and environmental influences, across all life stages.
Kavanagh
Kylie
K
Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA. kkavanag@wfubmc.edu
Fairbanks
Lynn A
LA
Bailey
Julia N
JN
Jorgensen
Matthew J
MJ
Wilson
Martha
M
Zhang
Li
L
Rudel
Lawrence L
LL
Wagner
Janice D
JD
D000818:Animals; D049628:Body Size; D001835:Body Weight; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000097:blood / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000235:genetics; D012307:Risk Factors; D012727:Sex Characteristics
D006442:Glycated Hemoglobin