A novel model for an older remodeler: the BAF swap in neurogenesis.
Changes in chromatin state contribute to the switch in gene expression programs that characterizes the transition of dividing neural stem cells toward a neuronal fate. In this issue of Neuron, Lessard et al. show that this process is regulated by specific cofactor exchanges within the SWI/SNF chromatin remodeling complex.
Aigner
Stefan
S
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Denli
Ahmet M
AM
Gage
Fred H
FH
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002843:Chromatin / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006657:Histones / Q000378:metabolism; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D013234:Stem Cells / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology
D002843:Chromatin; D006657:Histones; D009097:Multienzyme Complexes; D014157:Transcription Factors