Initiation to end point: the multiple roles of fibroblast growth factors in neural development.
From a wealth of experimental findings, derived from both in vitro and in vivo experiments, it is becoming clear that fibroblast growth factors regulate processes that are central to all aspects of nervous system development. Some of these functions are well known, whereas others, such as the roles of these proteins in axon guidance and synaptogenesis, have been established only recently. The emergent picture is one of remarkable economy, in which this family of ligands is deployed and redeployed at successive developmental stages to sculpt the nervous system.
Mason
Ivor
I
MRC Centre for Developmental Neurobiology, King's College London, Fourth floor New Hunt's House, Guy's Hospital Campus, London, SE1 1UL, UK. ivor.mason@kcl.ac.uk
D000818:Animals; D019521:Body Patterning / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D005346:Fibroblast Growth Factors / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D009420:Nervous System / Q000196:embryology* / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D008024:Ligands; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors