Differential diagnosis of hypercalcemia in renal malignancy.
We report a case of large cell B-cell lymphoma of the kidney associated with humoral hypercalcemia of malignancy. A 70-year-old man presented with renal failure and hypercalcemia. After the workup, the patient was thought to have renal cell carcinoma and underwent radical nephrectomy. The pathologic evaluation showed a large cell lymphoma with a B-cell phenotype. Reevaluation of the patient's serum revealed a high calcitriol level with low parathyroid hormone and parathyroid hormone-related protein levels, consistent with the final pathologic findings. The differential diagnosis of hypercalcemia in renal malignancy is presented.
Klatte
Tobias
T
Department of Urology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California 90095-1738, USA.
Said
Jonathan W
JW
Belldegrun
Arie S
AS
Pantuck
Allan J
AJ
D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis* / Q000209:etiology*; D007680:Kidney Neoplasms / Q000150:complications*; D016393:Lymphoma, B-Cell / Q000150:complications*; D008297:Male