The renal effects of alginates isolated from brown seaweed Sargassum vulgare.
Alginates isolated from Sargassum vulgare, present a strong antitumor activity, associated with kidney reversible damage, as analysed by histopathology of treated animals. In the present study, the renal alteration mechanisms of S. vulgare alginates were investigated using the isolated perfused rat kidney and the isolated perfused rat mesenteric blood vessel methods. The results showed that the effects of Sargassum vulgare low viscosity (SVLV) alginate were more potent than those of Sargassum vulgare high viscosity (SVHV) alginate in the isolated rat kidney. The SVLV alginate caused considerable changes in renal physiology, as shown by an increase in parameters such as perfusion pressure, renal vascular resistance, glomerular filtration rate, urinary flow and sodium, potassium and chloride excretion and by reduction of chloride tubular transport. The effects of SVHV were weaker than those of SVLV. The effects of SVLV on kidney could be related to direct vascular action as demonstrated with SVLV alginate on mesenteric blood vessels. In conclusion, the Sargassum vulgare alginate altered the renal function parameters evaluated. S. vulgare low viscosity alginate renal effects were more potent than S. vulgare high viscosity alginate. It is suggested that physicochemical differences between SVHV and SVLV could explain the differences found in the results.
de Paula Alves Sousa
Alessandra
A
Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, P.O. Box-3157, 60430-270, Fortaleza, Ceará, Brasil.
Barbosa
Paulo Sergio Ferreira
PS
Torres
Márcia Rocha
MR
Martins
Alice Maria Costa
AM
Martins
René Duarte
RD
de Sousa Alves
Renata
R
de Sousa
Daniel Freire
DF
Alves
Claudênio Diógenes
CD
Costa-Lotufo
Letícia Veras
LV
Monteiro
Helena Serra Azul
HS
D000284:Administration, Oral; D000464:Alginates / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D007677:Kidney Function Tests; D010477:Perfusion; D010936:Plant Extracts / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D044647:Sargassum / Q000737:chemistry*; D013152:Splanchnic Circulation / Q000187:drug effects / Q000502:physiology; D014783:Viscosity
D000464:Alginates; D010936:Plant Extracts