title: [Glial tumors of the brain: current aspects of the immunopathogenesis and immunogenodiagnosis].
abstract: Glioblastoma growth is a genetically regulated process. Loss or inactivation of genes - tumor suppressors may give rise to tumors and their progression. Glioblastoma multiforme is followed by a number of genetic breakages. Expression of a number of genes may affect the prognosis of the disease and tumor sensitivity to chemotherapy. Comprehensive studies of glioblastomas showed that there were at least two immunologic phenotypes: 1) that with a picture of pronounced immunodeficiency and 2) that without obvious immunodeficiency. This should be considered when elaborating present-day programs of geno- and immunodiagnosis, as well as clinicoimmunological criteria for the treatment of these tumors.
authors.forename: I I
authors.initials: II
authors.lastname: Anan'eva
authors.forename: M S
authors.initials: MS
authors.lastname: Malkarov
authors.forename: N A
authors.initials: NA
authors.lastname: Korsakova
authors.forename: A E
authors.initials: AE
authors.lastname: Dorofeev
authors.forename: I A
authors.initials: IA
authors.lastname: Kachkov
authors.forename: S V
authors.initials: SV
authors.lastname: Suchkov
authors.forename: A S
authors.initials: AS
authors.lastname: Balkanov
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000473:pathology; D005909:Glioblastoma / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000473:pathology; D006801:Humans; D007125:Immunogenetics; D007159:Immunologic Tests; D017628:Microglia / Q000276:immunology / Q000473:pathology