Enantioselective synthesis of (s)- and (R)-tolterodine by asymmetric hydrogenation of a coumarin derivative obtained by a Heck reaction.
An efficient and short enantioselective synthesis of (S)- and (R)-tolterodine was performed by asymmetric hydrogenation of a coumarin intermediate, easily obtained by a Heck reaction from inexpensive and commercially available starting materials.
Ulgheri
Fausta
F
Istituto di Chimica Biomolecolare-CNR, Traversa La Crucca, 3-Baldinca, I-07040 Sassari, Italy. f.ulgheri@ss.icb.cnr.it
Marchetti
Mauro
M
Piccolo
Oreste
O
D001559:Benzhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D003374:Coumarins / Q000737:chemistry*; D003408:Cresols / Q000138:chemical synthesis / Q000737:chemistry*; D008024:Ligands; D008956:Models, Chemical; D010665:Phenylpropanolamine / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature; D000068737:Tolterodine Tartrate; D014867:Water / Q000737:chemistry
D001559:Benzhydryl Compounds; D003374:Coumarins; D003408:Cresols; D008024:Ligands; D014867:Water; D010665:Phenylpropanolamine; D000068737:Tolterodine Tartrate; C030123:coumarin