title: The master key effect of vitamin B12 in treatment of malignancy--a potential therapy?
abstract: Vitamin B12 plays a functional role in a variety of organs and body systems and the list of these organs and body systems is growing. According to our working hypothesis ("Master Key Effect") vitamin B12 has some unique functions, which are still not accepted; vitamin B12 functions to keep body systems in balance, even under the stress of severe pathology. What is the explanation for elevation of cobalamin level in oncological patients? As yet I have not been able to find another explanation for high level of vitamin B12 in oncology patients other than that it is a compensatory mechanism. Perhaps following this body's "warning sign", we should start treatment with high doses of vitamin B12 to try to help the stabilization of normal function of the organs and systems. Laboratory researches should be continued to substantiate introduction of cobalamin as preliminary treatment of particular diseases.
authors.affiliation: Department of Family Medicine, Faculty of Health Sciences, Ben-Gurion University of the Negev, Lea Imenu St. 59/2, Beer-Sheva 84514, Israel. r0019@zahav.net.il <r0019@zahav.net.il>
authors.forename: Ilia
authors.initials: I
authors.lastname: Volkov
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019175:DNA Methylation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011379:Prognosis; D014805:Vitamin B 12 / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D014805:Vitamin B 12