title: Chronic hypersensitivity pneumonitis: CT features comparison with pathologic evidence of fibrosis and survival.
abstract: OBJECTIVE
  To retrospectively compare in patients with chronic hypersensitivity pneumonitis (HP) the computed tomographic (CT) imaging features suggestive of fibrosis with pathologic evidence of fibrosis at surgical lung biopsy and to compare a usual interstitial pneumonia (UIP) pattern at CT with survival.
  
  
  METHODS
  Institutional review board approval and informed consent were obtained for this study, which was HIPAA compliant. Twenty-six patients (15 women, 11 men; age range, 37-76 years) with chronic HP had their surgical lung biopsy results reviewed by two pathologists for the presence of fibrosis. Two radiologists systematically reviewed the CT scans. The two radiologists were blinded to all clinical information, including pathologic diagnosis, patient information, and outcomes. The combination of a subpleural reticular pattern and lower zone predominance was considered a UIP pattern. CT findings were compared with the histopathologic presence of fibrosis, physiologic parameters, symptoms, and survival. The chi(2) or Fisher exact test (each two-tailed) was used to compare nominal and ordinal variables. A t test (with unequal variances) was used to compare continuous variables. The log-rank procedure was used to compare Kaplan-Meier survival curves.
  
  
  RESULTS
  Fifteen patients had fibrotic HP at biopsy, and 11 had nonfibrotic HP. Patients with fibrotic HP had more extensive reticular pattern and were more likely to have traction bronchiectasis, honeycombing, and a UIP pattern than those with nonfibrotic HP (P = .015, P = .007, P = .007, respectively). Although the presence of histologic fibrosis was associated with decreased survival (P = .003), the CT features were not associated with decreased survival.
  
  
  CONCLUSIONS
  CT findings of extensive reticular pattern, traction bronchiectasis, and honeycombing are closely related to the presence of histologic fibrosis in chronic HP.
authors.affiliation: Department of Radiology, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA. sahinh@njc.org
authors.forename: Hakan
authors.initials: H
authors.lastname: Sahin
authors.forename: Kevin K
authors.initials: KK
authors.lastname: Brown
authors.forename: Douglas
authors.initials: D
authors.lastname: Curran-Everett
authors.forename: Valerie
authors.initials: V
authors.lastname: Hale
authors.forename: Carlyne D
authors.initials: CD
authors.lastname: Cool
authors.forename: Jason S
authors.initials: JS
authors.lastname: Vourlekis
authors.forename: David A
authors.initials: DA
authors.lastname: Lynch
mesh_terms: D000328:Adult; D000368:Aged; D000542:Alveolitis, Extrinsic Allergic / Q000000981:diagnostic imaging* / Q000473:pathology; D001706:Biopsy; D016009:Chi-Square Distribution; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed