title: Three new cytotoxic Diels-Alder-type adducts from Morus australis.
abstract: Three new natural products, australisines A-C (1-3, resp.), were isolated from the stem bark of Morus australis, together with eight related compounds, including mulberrofurans E-G, J, and Q, mongolicin C, chalcomoracin, and kuwanon G. Their structures were fully characterized by spectroscopic methods. Compounds 1-3, mulberrofuran G, mongolicin C, and chalcomoracin showed moderate cytotoxic activities against five human cancer cell lines, with IC50 values ranging from 4.6-9.2 microg/ml, as determined by MTT assay.
authors.affiliation: The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, PR China.
authors.forename: Qing-Jian
authors.initials: QJ
authors.lastname: Zhang
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Tang
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D031625:Morus; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity; D018547:Plant Stems; D016337:RNA, Catalytic / Q000633:toxicity*
chemical_list: D003603:Cytotoxins; C518747:Diels-Alder ribozyme; D010936:Plant Extracts; D016337:RNA, Catalytic