title: Effect of gluten-free diet and co-morbidity of irritable bowel syndrome-type symptoms on health-related quality of life in adult coeliac patients.
abstract: BACKGROUND
  Both coeliac disease and irritable bowel syndrome show impaired health-related quality of life, however, the impact of irritable bowel syndrome-type symptoms on health-related quality of life in coeliac disease is unclear.
  
  
  OBJECTIVE
  To evaluate the effect of gluten-free diet adherence and irritable bowel syndrome-type symptoms co-morbidity on health-related quality of life in adult coeliac disease patients.
  
  
  METHODS
  A total of 1130 adults were enrolled in the study comprising 1001 controls from the general population and 129 diagnosed coeliac disease patients from the University Clinic in Cagliari. Irritable bowel syndrome-type symptoms and health-related quality of life were assessed using the Rome II and the SF-36 questionnaires, respectively.
  
  
  RESULTS
  Irritable bowel syndrome-type symptoms prevalence in controls was 10.1% (102/1001) and 55% (71/129) in the coeliac disease patients. Irritable bowel syndrome-type symptom controls and coeliac disease patients both presented significantly lower health-related quality of life (p<or=0.05) compared to healthy controls. Strict diet coeliac disease patients, compared to partial diet patients, showed significantly (p<or=0.05) better scores in all domains, except physical functioning, physical-role and bodily pain. The lowest scores were found in partial diet coeliac disease patients with irritable bowel syndrome-type symptoms.
  
  
  CONCLUSIONS
  The present results confirm the burden of irritable bowel syndrome-type symptoms and coeliac disease on health-related quality of life. Moreover, these data show that health-related quality of life in coeliac disease is impaired by poor compliance and by co-morbidity with irritable bowel syndrome-type symptoms.
authors.affiliation: Gastroenterology Unit, University of Cagliari, S.S. 554 Bivio per Sestu, 09042 Monserrato (CA), Italy. usaip@pacs.unica.it
authors.forename: P
authors.initials: P
authors.lastname: Usai
authors.forename: R
authors.initials: R
authors.lastname: Manca
authors.forename: R
authors.initials: R
authors.lastname: Cuomo
authors.forename: M A
authors.initials: MA
authors.lastname: Lai
authors.forename: M F
authors.initials: MF
authors.lastname: Boi
mesh_terms: D000293:Adolescent; D000328:Adult; D002446:Celiac Disease / Q000150:complications / Q000178:diet therapy*; D005260:Female; D005983:Glutens; D006304:Health Status; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D005983:Glutens