Feasibility of mesothelial transplantation during experimental peritoneal dialysis and peritonitis.
The mesothelial cell layer lining the peritoneum orchestrates peritoneal homeostasis. Continuous exposure to peritoneal dialysis fluids and episodes of peritonitis may damage the monolayer irreversibly, eventually leading to adhesion formation and fibrosis/sclerosis of the peritoneum. Autologous mesothelial cell transplantation is thought to be one of the options to reduce dysfunction of the peritoneal membrane. In this article we will review the mesothelial cell transplantation experiments performed in the field of peritoneal dialysis and peritonitis. In addition we will focus on the trouble shooting using cultured autologous mesothelial cells for transplantation.
Hekking
L H
LH
Department of Cellular Architecture and Dynamics, University of Utrecht, Utrecht, The Netherlands.
van den Born
J
J
D000818:Animals; D002478:Cells, Cultured; D015314:Dialysis Solutions / Q000009:adverse effects; D004847:Epithelial Cells / Q000502:physiology / Q000637:transplantation*; D004848:Epithelium / Q000502:physiology / Q000637:transplantation; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000166:cytology*; D010538:Peritonitis / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D000267:Tissue Adhesions / Q000517:prevention & control; D014182:Transplantation, Autologous
D015314:Dialysis Solutions