[Expression and significance of DNA topoisomerase I (topo I) in small cell lung cancer].
OBJECTIVE
To investigate the expression and its significance of DNA topoisomerase I (Topo I) in small cell lung cancer (SCLC).


METHODS
Topo I expression was detected by immunohistochemical S-P technique on 50 cases of SCLC and 12 cases of normal lung tissues.


RESULTS
The total positive rate of Topo I in normal lung tissue was 25.0% (3/12) and 78.0% (39/50) in SCLC. The expression of Topo I does not correlate with age, gender, smoking, tumor size and tumor site (P > 0.05), but significantly correlated with lymph node metastasis and clinical stage (P <0.05).


CONCLUSIONS
High Topo I expression is a rationale indication of Topo I inhibitor treatment of malignancies. It should be possible to predict anti-tumor drug sensitivity by assessment of Topo I expression and help to improve the therapeutic efficacy for cancer patients.
Guo
Qi-Sen
QS
Department of Internal Medecine, Shandong Tumor Hospital, Jinan 250117, China. guoqisen@csco.org.cn
Liu
Yan-Xia
YX
Yu
Jin-Ming
JM
Wang
Jia-Lin
JL
Zhong
Wei-Xia
WX
Liu
Xiu-Ju
XJ
D018288:Carcinoma, Small Cell / Q000201:enzymology* / Q000473:pathology; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008175:Lung Neoplasms / Q000201:enzymology* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
D004264:DNA Topoisomerases, Type I