title: Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists.
abstract: A series of constrained piperidine analogues were synthesized as novel muscarinic M(3) receptor antagonists. Evaluation of these compounds in binding assays revealed that they not only have high affinity for the M(3) receptor but also have high selectivity over the M(2) receptor.
authors.affiliation: Ranbaxy Research Laboratories, New Drug Discovery Research, Department of Medicinal Chemistry, Gurgaon, Haryana 122 001, India. n.kumar@ranbaxy.com
authors.forename: Naresh
authors.initials: N
authors.lastname: Kumar
authors.forename: Kirandeep
authors.initials: K
authors.lastname: Kaur
authors.forename: Shelly
authors.initials: S
authors.lastname: Aeron
authors.forename: Sankaranarayanan
authors.initials: S
authors.lastname: Dharmarajan
authors.forename: Arun D V
authors.initials: AD
authors.lastname: Silamkoti
authors.forename: Anita
authors.initials: A
authors.lastname: Mehta
authors.forename: Suman
authors.initials: S
authors.lastname: Gupta
authors.forename: Anita
authors.initials: A
authors.lastname: Chugh
authors.forename: Jang B
authors.initials: JB
authors.lastname: Gupta
authors.forename: Mohammad
authors.initials: M
authors.lastname: Salman
authors.forename: Venkata P
authors.initials: VP
authors.lastname: Palle
authors.forename: Ian A
authors.initials: IA
authors.lastname: Cliffe
mesh_terms: D018727:Muscarinic Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D043587:Receptor, Muscarinic M3 / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D018727:Muscarinic Antagonists; D043587:Receptor, Muscarinic M3