title: Cost-effectiveness of identifying aortoiliac and femoropopliteal arterial disease with angiography or duplex scanning.
abstract: OBJECTIVE
  Cost-effectiveness analysis of three diagnostic imaging strategies for the assessment of aortoiliac and femoropopliteal arteries in patients with peripheral arterial occlusive disease. The strategies were: angiography as the reference strategy, duplex scanning (DS) plus supplementary angiography (S1) and DS plus confirmative angiography (S2).
  
  
  METHODS
  A decision model was built with sensitivity and specificity data from literature, supplemented with prospective hospital cost data in Euro (euro). The probability of correctly identifying the status of a lesion was taken as the primary outcome. We compared strategies by assessing the extra costs per additional correctly identified case.
  
  
  RESULTS
  Assuming no false positive or false negative results, angiography is the most effective strategy if the prevalence of significant obstructive lesions in the aortoiliac and femoropopliteal tract exceeds 70%, or if the sensitivity of duplex scanning is lower than 83%. In case of lower prevalence, strategy S1 becomes equally or even more effective than angiography. At a prevalence of 75%, performing angiography costs euro 8443 per extra correctly identified case compared with strategy S1.
  
  
  CONCLUSIONS
  In most situations angiography is more effective than diagnostic strategy S1. However, if society is unwilling to pay more than euro 8443 for knowing a patient's disease status, diagnostic strategy S1 is a cost-effective alternative to angiography, especially at lower prevalence values.
authors.affiliation: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: S B
authors.initials: SB
authors.lastname: Coffi
authors.forename: D Th
authors.initials: DT
authors.lastname: Ubbink
authors.forename: M G W
authors.initials: MG
authors.lastname: Dijkgraaf
authors.forename: J A
authors.initials: JA
authors.lastname: Reekers
authors.forename: D A
authors.initials: DA
authors.lastname: Legemate
mesh_terms: D000792:Angiography / Q000191:economics*; D001018:Aortic Diseases / Q000000981:diagnostic imaging*; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging*; D003362:Cost-Benefit Analysis; D003663:Decision Trees; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006801:Humans; D007083:Iliac Artery / Q000000981:diagnostic imaging; D016491:Peripheral Vascular Diseases / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D018616:Ultrasonography, Doppler, Duplex / Q000191:economics*