[Structure and function of apolipoprotein and prevention and therapy of virus diseases].
Apolipoprotein, an important component of the lipoproteins, modulates the activity of enzyme, introduces the binding of cell receptor and lipoproteins, and keeps the structural stability of lipoproteins. The amphipathic helices structure in apolipoproteins is the structural basis that it binds and transports lipids. A certain envelope glycoprotein (gp) in the outer membrane of HIV also has been found to be with such amphipathic helices structure. Recent studies have shown that the liposome consisted of apolipoproteins and phospholipids may defend against HCV, HIV, and herpes simplex virus, and even neutralize the endotoxin released by bacteria. The liposome made up of apolipoproteins and phospholipid has became a potential carrier for anti-tumor and anti-virus drugs.
Chen
Bao-sheng
BS
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China. BSChen@ibms.pumc.edu.cn
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000998:Antiviral Agents / Q000008:administration & dosage; D001053:Apolipoproteins / Q000737:chemistry / Q000502:physiology; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry; D011487:Protein Conformation; D014777:Virus Diseases / Q000188:drug therapy / Q000517:prevention & control
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001053:Apolipoproteins; D008081:Liposomes; D010743:Phospholipids