[Participation of platelets in the process of fibrosis in patients with mansonic schistosomiasis].
The aim of this study was to evaluate platelet activation through P-selectin, and PDGF-AB and TGF beta 1 content, in schistosomiasis patients who developed fibrosis (F3) and who did not present this (F0), and in a control group (C). The results showed that the percentage of P-selectin in platelets without agonist stimulation was 10.6% in F3, 11.1% in F0 and 6.3% in C. After the addition of ADP/adrenaline, the percentages were 44%, 25.3% and 42%, respectively. The PDGF-AB and TGF beta 1 contents per platelet were 11,016 ng/dl (F3), 3,172 ng/dl (F0) and 5.01 ng/dl (C) and 0,012 ng/dl (F3), 5.27 ng/dl (F0) and 4.66 ng/dl (C), respectively. Concerning the P-selectin, we can conclude that platelets from patients with schistosomiasis continued to be responsive to agonists, despite being pre-activated. There were no differences in TGF beta 1 between the groups, but the PDGF-AB content was significantly higher in F3. This suggests that PDGF-AB may have some participation in the development of fibrosis.
Soares
Sheila
S
Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil. ura.gtecnica@hemominas.mg.gov.br
Rodrigues Júnior
Virmondes
V
Silva
David Teixeira Nascimento
DT
Moraes-Souza
Helio
H
D016022:Case-Control Studies; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000469:parasitology / Q000503:physiopathology; D019007:P-Selectin / Q000097:blood*; D015539:Platelet Activation / Q000502:physiology*; D010976:Platelet Count; D010982:Platelet-Derived Growth Factor / Q000032:analysis*; D012555:Schistosomiasis mansoni / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D053773:Transforming Growth Factor beta1 / Q000097:blood*
D019007:P-Selectin; D010982:Platelet-Derived Growth Factor; D053773:Transforming Growth Factor beta1; C095477:platelet-derived growth factor AB