title: Iron sulfur cluster biosynthesis. Human NFU mediates sulfide delivery to ISU in the final step of [2Fe-2S] cluster assembly.
abstract: Human NFU forms a complex with NifS-like proteins and is a functionally competent reducing agent for cysteinyl persulfide bond cleavage, releasing inorganic sulfide for incorporation into the ISU-bound [2Fe-2S] cluster.
authors.affiliation: Evans Laboratory of Chemistry, Ohio State University, 100 West, 18th Ave, Columbus, OH 43210, USA. cowan@chemistry.ohio-state.edu.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Liu
authors.forename: J A
authors.initials: JA
authors.lastname: Cowan
mesh_terms: D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D007506:Iron-Sulfur Proteins / Q000096:biosynthesis*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D013440:Sulfides / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D007506:Iron-Sulfur Proteins; C426067:NFU1 protein, human; D011506:Proteins; D013440:Sulfides