Rhodethrin: a novel indole terpenoid ether produced by Rhodobacter sphaeroides has cytotoxic and phytohormonal activities.
A novel metabolite was isolated from the culture supernatants of Rhodobacter sphaeroides OU5 when grown on L-tryptophan as sole source of nitrogen under photoheterotrophic conditions. It was identified by IR, NMR ((1)H, (13)C) and MS as an indole terpenoid ether [3-hydroxy-6-(1H-indol-3-yloxy)-4-methylhexanoic acid] and is named as rhodethrin. Rhodethrin at 0.5 microM gave positive test in auxin bioassay and initiated early rooting in tissue-cultured plants than IAA at 5 microM. Rhodethrin has cytotoxic activity against Sup-T(1) lymphoma and Colo-125 cancer cell lines at 10 nM.
Ranjith
N Kumavath
NK
Department of Plant Sciences, School of Life Sciences, University of Hyderabad, P.O. Central University, Hyderabad, 500 046, India.
Sasikala
Ch
Ch
Ramana
Ch Venkata
ChV
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000503:physiopathology*; D031625:Morus / Q000378:metabolism / Q000502:physiology*; D010937:Plant Growth Regulators / Q000378:metabolism*; D012242:Rhodobacter sphaeroides / Q000378:metabolism*; D046948:Secologanin Tryptamine Alkaloids / Q000008:administration & dosage* / Q000378:metabolism*
D010937:Plant Growth Regulators; D046948:Secologanin Tryptamine Alkaloids