[Chondroitin sulfate proteoglycans in neural development and regeneration].
Chondroitin sulfate proteoglycans (CSPGs) are major components of extracellular matrix in the central nervous system (CNS) , and play important roles in the development and maintenance of CNS, as welt in pathogenesis or repair processes of neuronal damages. They mainly exert barrier function for neuronal migration and axonogenesis during development and inhibitory effects on plasticity and axon re-growth in the adult nerve system. Digestion of glycosaminoglycan (GAG) chains or suppression of their synthesis could promote axonal regeneration and functional recovery after CNS injuries. However, many questions about the mechanisms regulating their expression pattern and signal transductions mediating their effects on neurons remain to be investigated.
Gu
Wen-Li
WL
Department of Neurobiology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Lu
Pei-Hua
PH
D000818:Animals; D011508:Chondroitin Sulfate Proteoglycans / Q000502:physiology*; D005109:Extracellular Matrix / Q000737:chemistry; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D009420:Nervous System / Q000254:growth & development*; D009473:Neuronal Plasticity / Q000502:physiology*; D015398:Signal Transduction
D011508:Chondroitin Sulfate Proteoglycans; D006025:Glycosaminoglycans