title: [Association between A1168C polymorphism in PAX4 gene and type 1 diabetes in Han Chinese].
abstract: OBJECTIVE
  To explore whether A1168C polymorphisms in paired box gene 4 (PAX4) are associated with type 1 diabetes mellitus (T1DM) in Chinese Han population.
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype A1168C polymorphisms in PAX4 gene. Totally 109 patients with T1DM and 251 control subjects were recruited. The frequency distributions of genotypes between two groups were analyzed by SPSS software.
  
  
  RESULTS
  The genotype distributions were in Hardy-Weinberg equilibrium both among T1DM cases and control subjects. No difference was observed in the genotype frequencies and allele frequencies between T1DM cases and control subjects (P > 0.05), nor was any disease association detected when patients were stratified according to age at diagnosis or sex (P > 0.05).
  
  
  CONCLUSIONS
  The A1168C single nucleotide polymorphism in PAX4 gene may not play an essential role in genetic T1DM susceptibility in Chinese Han population.
authors.affiliation: Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xin-hua
authors.initials: XH
authors.lastname: Xiao
authors.forename: Heng
authors.initials: H
authors.lastname: Wang
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.forename: Guo-hua
authors.initials: GH
authors.lastname: Yang
authors.forename: Yong
authors.initials: Y
authors.lastname: Fu
authors.forename: Tao
authors.initials: T
authors.lastname: Yuan
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Qiu-ying
authors.initials: QY
authors.lastname: Liu
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D051761:Paired Box Transcription Factors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D018398:Homeodomain Proteins; C491709:PAX4 protein, human; D051761:Paired Box Transcription Factors