title: Blastomyces antigen detection for monitoring progression of blastomycosis in a pregnant adolescent.
abstract: Although disseminated blastomycosis is a rare complication in pregnancy, delay in diagnosis and treatment can be fatal. We investigate the use of the Blastomyces urine antigen in diagnosis following disease progression in the intrapartum, postpartum, and neonatal periods. We describe a case of disseminated blastomycosis in a pregnant adolescent and review the pertinent literature regarding treatment and monitoring blastomycosis in pregnancy and the neonatal periods. This is the first reported case in which the Blastomyces urine antigen is utilized as a method of following disease activity during pregnancy confirming absence of clinically evident disease in a neonate. Urine antigen detection for blastomycosis can be useful for following progression of disease in patients with disseminated blastomycosis in both the intrapartum and postpartum periods.
authors.affiliation: Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Megan
authors.initials: M
authors.lastname: Tarr
authors.forename: John
authors.initials: J
authors.lastname: Marcinak
authors.forename: Kanokporn
authors.initials: K
authors.lastname: Mongkolrattanothai
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Burns
authors.forename: L Joseph
authors.initials: LJ
authors.lastname: Wheat
authors.forename: Michelle
authors.initials: M
authors.lastname: Durkin
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Ismail
mesh_terms: D000293:Adolescent; D000946:Antigens, Fungal / Q000652:urine*; D001758:Blastomyces / Q000302:isolation & purification*; D001759:Blastomycosis / Q000188:drug therapy / Q000382:microbiology / Q000652:urine*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000382:microbiology* / Q000652:urine*
chemical_list: D000946:Antigens, Fungal