title: [Nitrofurantoin-induced lung disease: about two cases].
abstract: BACKGROUND
  Nitrofurantoin is commonly used in the treatment of urinary tract infection and may cause a potential severe complication: interstitial lung diseases.
  
  
  METHODS
  A 78-year-old and an 87-year-old woman treated with nitrofurantoin since respectively 10 months and 6 years developed cough and dyspnea. Antibiotics were ineffective and interstitial lung disease was found. Nitrofurantoin's stopping allowed a clinical and radiological improvement.
  
  
  CONCLUSIONS
  A good medical supervision is important when nitrofurantoin is prescribed for a long time. The treatment has to be stopped when respiratory symptoms appear to allow an improvement of the symptoms.
authors.affiliation: Service de médecine interne, CHU Gabriel-Montpied, 58, rue Montalembert, B.P. 69, 63003 Clermont-Ferrand cedex 01, France.
authors.forename: N
authors.initials: N
authors.lastname: Mrozek
authors.forename: I
authors.initials: I
authors.lastname: Delèvaux
authors.forename: M
authors.initials: M
authors.lastname: Legendre
authors.forename: M
authors.initials: M
authors.lastname: André
authors.forename: S
authors.initials: S
authors.lastname: Trouillier
authors.forename: H
authors.initials: H
authors.lastname: Voinchet
authors.forename: O
authors.initials: O
authors.lastname: Aumaitre
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D003371:Cough / Q000139:chemically induced; D004417:Dyspnea / Q000139:chemically induced; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000503:physiopathology; D008448:Maximal Expiratory Flow Rate / Q000187:drug effects; D009582:Nitrofurantoin / Q000009:adverse effects*; D014109:Total Lung Capacity / Q000187:drug effects; D014797:Vital Capacity / Q000187:drug effects
chemical_list: D000892:Anti-Infective Agents, Urinary; D009582:Nitrofurantoin