Organic solvent nanofiltration for microfluidic purification of poly(amidoamine) dendrimers.
A nanofiltration method has been developed in a microfluidic format for the continuous-flow pressure-driven purification of half-generation poly(amidoamine) (PAMAM) dendrimers, a family of macromolecules characterized by highly branching structures radiating from a central core, without additional solvents or buffers. An organic solvent resistant nanofiltration membrane, STARMEM 122, has been fully integrated into a hard polymer microfluidic module by transmission laser welding. The membrane was initially characterized in a bench-top test fixture to determine the solvent permeance and percent rejection of a surrogate molecule, Rhodamine B, at lower than typical operating pressures (P<7 bar). The microfluidic module then underwent similar testing at 1.4 bar with the surrogate and with the generation-0.5 PAMAM dendrimer. This approach to nanofiltration will readily interface to upstream microreactors.
Rundel
Jack T
JT
Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA.
Paul
Brian K
BK
Remcho
Vincent T
VT
D050091:Dendrimers; D005374:Filtration / Q000295:instrumentation / Q000379:methods; D044085:Microfluidics / Q000295:instrumentation / Q000379:methods*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D009930:Organic Chemicals / Q000737:chemistry; D011073:Polyamines / Q000032:analysis* / Q000737:chemistry; D015203:Reproducibility of Results; D012997:Solvents / Q000737:chemistry*
D050091:Dendrimers; D009930:Organic Chemicals; C104700:PAMAM Starburst; D011073:Polyamines; D012997:Solvents