TRAFs in RANK signaling.
Members of the tumor necrosis factor (TNF) family govern many diverse physiological and cellular responses including cellular proliferation, differentiation, and apoptosis. Ligands of this family interact through a distinct set of specific receptors that lack enzymatic activity and therefore are dependent on the association of adaptor molecules. One receptor/ligand pair known as receptor activator of nuclear factor-kappa B (RANK) and RANK ligand (RANKL) regulates bone remodeling, mammary gland development, and lymph node organogenesis. RANK interacts with five members of the TNF receptor-associated factor (TRAF) family, of which TRAF6 is indispensable for its signaling capability. An accumulation of evidence from various research laboratories indicates TRAFs, but more importantly TRAF6, is the key to understanding how RANKL links cytoplasmic signaling to the nuclear transcriptional program.
Darnay
Bryant G
BG
Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. bdarnay@mdanderson.org
Besse
Arnaud
A
Poblenz
Ann T
AT
Lamothe
Betty
B
Jacoby
Jörg J
JJ
D000818:Animals; D006801:Humans; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
D053246:Receptor Activator of Nuclear Factor-kappa B; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins