title: Proteoglycanomics: tools to unravel the biological function of glycosaminoglycans.
abstract: Glycosylation is the most frequent PTM and contributes significantly to the function of proteins depending on the type of glycosylation. Especially glycan structures like the glycosaminoglycans are considered to constitute themselves the major function of the glycoconjugate which is therefore termed proteoglycan. Here we review recent views on and novel tools for analysing the proteoglycanome, which are directly related to the type of glycanation under investigation. We define the major function of the proteoglycanome to be its interaction with various proteins in many different (patho-)physiological conditions. This is exemplified by the differential glycosaminoglycan-interactome of healthy versus arthritic patient sera.
authors.affiliation: Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria.
authors.forename: Bernd
authors.initials: B
authors.lastname: Gesslbauer
authors.forename: Angelika
authors.initials: A
authors.lastname: Rek
authors.forename: Fabio
authors.initials: F
authors.lastname: Falsone
authors.forename: Erich
authors.initials: E
authors.lastname: Rajkovic
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Kungl
mesh_terms: D006023:Glycoproteins / Q000737:chemistry; D006025:Glycosaminoglycans / Q000737:chemistry / Q000502:physiology*; D011134:Polysaccharides / Q000737:chemistry*; D040901:Proteomics
chemical_list: D006023:Glycoproteins; D006025:Glycosaminoglycans; D011134:Polysaccharides