A meal rich in oleic acid beneficially modulates postprandial sICAM-1 and sVCAM-1 in normotensive and hypertensive hypertriglyceridemic subjects.
This study investigated whether subjects with permanent activated endothelium have altered soluble forms of intercellular adhesion molecule 1 (sICAM-1) and vascular cell adhesion molecule 1 (sVCAM-1) postprandial response to a high-fat meal and whether this phenomenon is modulated by the nature of dietary fats. Twenty-eight hypertriglyceridemic (14 normotensives and 14 hypertensives) and 14 healthy male subjects were placed in a randomized and crossover design on diets enriched in refined olive oil (ROO) or high-palmitic sunflower oil (HPSO) for a 1-week lead-in period. Thereafter, subjects ate the corresponding fat-rich meal as a breakfast and underwent sampling hourly for 8 h. Plasma triglycerides (TG), sICAM-1 and sVCAM-1 were assayed. sICAM-1 and sVCAM-1 postprandial peak levels were significantly higher and occurred later in hypertriglyceridemic subjects (all P<.001) compared with healthy subjects. ROO meal resulted in smaller areas under the curve for sICAM-1 and sVCAM-1 in hypertriglyceridemic (normotensive and hypertensive) and healthy subjects compared to HPSO meal. Hypertension did not aggravate the postprandial response of TG, sICAM-1 and sVCAM-1. We conclude that the challenge of a meal with ROO appears to have a significant postprandial benefit on sICAM-1 and sVCAM-1 as surrogate markers of endothelial activation and vascular inflammation in healthy and more importantly in hypertriglyceridemic (normotensive and hypertensive) subjects.
Pacheco
Yolanda M
YM
Cellular and Molecular Nutrition, Instituto de la Grasa (CSIC), 41012 Seville, Spain.
López
Sergio
S
Bermúdez
Beatriz
B
Abia
Rocío
R
Villar
José
J
Muriana
Francisco J G
FJ
D000328:Adult; D018592:Cross-Over Studies; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005502:Food; D006801:Humans; D006973:Hypertension / Q000097:blood*; D015228:Hypertriglyceridemia / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D019301:Oleic Acid / Q000008:administration & dosage*; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D004042:Dietary Fats, Unsaturated; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D019301:Oleic Acid