Bone mass of a 113-year-old man.
Osteoporosis is a common disease that affects elderly people. Aging induces loss of bone density and quality resulting in a progressive incidence of fragility fractures. In this study, we report the bone density of one of the oldest men in the world and of several of his first-degree relatives, as well as a genetic screen of these cases. No fractures have been suffered by any of them, and their bone mineral density (BMD) values in terms of z score were normal or lightly decreased. Neither mutations at the longevity-related gene KLOTHO nor the Gly171Val mutation of LRP5 associated with high bone mass was detected in the two centenarian stepbrothers.
Mellibovsky
Leonardo
L
Hospital del Mar, Unidad de Recerca en Fisiopatología Osea i Articular, Institut d'Investigació Medica, Universidad Autónoma de Barcelona, 08003, Spain. lmellibovsky@imas.imim.es
Bustamante
Mariona
M
Lluch
Pau
P
Nogues
Xavier
X
Grinberg
Daniel
D
Balcells
Susana
S
Diez-Perez
Adolfo
A
D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D005260:Female; D005966:Glucuronidase / Q000235:genetics; D006801:Humans; D000090265:Klotho Proteins; D008136:Longevity / Q000235:genetics; D008297:Male
D005966:Glucuronidase; D000090265:Klotho Proteins