title: Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition.
abstract: The antiproliferative activity of fresh fruit juices extracted from Citrus sinensis (cv. Washington Navel and cv. Sanguinello), C. deliciosa cv. Avana, C. clementina cv. Nules, C. aurantium subsp. myrtifolia , was evaluated against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and MCF-7 (human breast adenocarcinoma) cell lines. All the juices tested showed antiproliferative activity. Moreover, the pattern of the main flavanone compounds in the juices has been determined by HPLC analysis.
authors.affiliation: Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, via Archirafi 32, 90123, Palermo, Italy. camarnat@unipa.it
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Camarda
authors.forename: Vita
authors.initials: V
authors.lastname: Di Stefano
authors.forename: Sergio Fatta
authors.initials: SF
authors.lastname: Del Bosco
authors.forename: Domenico
authors.initials: D
authors.lastname: Schillaci
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D002957:Citrus; D044950:Flavanones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005638:Fruit; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D020014:K562 Cells / Q000187:drug effects; D008517:Phytotherapy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044950:Flavanones; C028610:flavanone