[HIV-1 Rev and related inhibitors].
HIV-1 Rev is an indispensable regulatory factor of the virion protein expression. The interaction between Rev and RRE RNA accelerates the nuclear export of viral mRNA. The unspliced and singly spliced mRNA will be degraded in the absence of Rev, resulting in the interception of HIV-1 replication at the same time. The pivotal role that Rev plays in HIV-1 replication as a trans-acting factor makes it a new target in the research of AIDS drugs. In this review, the function of Rev, Rev-RRE interaction, as well as their related inhibitors are reported.
Cao
Yuan
Y
Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
Liu
Xin-yong
XY
D021581:Active Transport, Cell Nucleus; D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D002467:Cell Nucleus / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology; D005601:Framycetin / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D028884:Karyopherins / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D014158:Transcription, Genetic; D014779:Virus Replication; D054321:rev Gene Products, Human Immunodeficiency Virus / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000097606:Exportin 1 Protein
D019380:Anti-HIV Agents; D005231:Fatty Acids, Unsaturated; D005601:Framycetin; D028884:Karyopherins; D012333:RNA, Messenger; D012367:RNA, Viral; D018160:Receptors, Cytoplasmic and Nuclear; D054321:rev Gene Products, Human Immunodeficiency Virus; D000097606:Exportin 1 Protein; C514860:rev protein, Human Immunodeficiency Virus-1; C038753:leptomycin B