Synthesis of fluorescent and photoaffinity-labeled derivatives of bisphenol A and their inhibitory activity toward hypoxic expression of erythropoietin.
Bisphenol A derivatives, possessing a fluorescent dye and a photo-reactive group, were synthesized from bisphenol A, and the inhibitory activity of the derivatives was evaluated against hypoxic response. The synthesized derivatives were found to inhibit the hypoxic expression of erythropoietin in Hep3B cells as well as bisphenol A.
Maezawa
Nobuhiro
N
Department of Chemistry and Open Research Center on Organic Tool Molecules, School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo 669-1337, Japan.
Tsuchikawa
Hiroshi
H
Katsumura
Shigeo
S
Kubo
Tomoko
T
Imaoka
Susumu
S
D001559:Benzhydryl Compounds; D015687:Cell Hypoxia; D004921:Erythropoietin / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D006801:Humans; D010636:Phenols / Q000737:chemistry*; D019920:Photoaffinity Labels / Q000138:chemical synthesis*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004921:Erythropoietin; D005456:Fluorescent Dyes; D010636:Phenols; D019920:Photoaffinity Labels; C006780:bisphenol A; D000098826:Bisphenol A Compounds