The continuing case for the Renshaw cell.
Renshaw cell properties have been studied extensively for over 50 years, making them a uniquely well-defined class of spinal interneuron. Recent work has revealed novel ways to identify Renshaw cells in situ and this in turn has promoted a range of studies that have determined their ontogeny and organization of synaptic inputs in unprecedented detail. In this review we illustrate how mature Renshaw cell properties and connectivity arise through a combination of activity-dependent and genetically specified mechanisms. These new insights should aid the development of experimental strategies to manipulate Renshaw cells in spinal circuits and clarify their role in modulating motor output.
Alvarez
Francisco J
FJ
Department of Neuroscience, Cell Biology & Physiology, Boonshoft School of Medicine, Wright State University, 3640 Col. Glenn Hwy, Dayton, OH 45435, USA. francisco.alvarez@wright.edu
Fyffe
Robert E W
RE
D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism; D007395:Interneurons / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D013569:Synapses / Q000648:ultrastructure
D002135:Calcium-Binding Proteins