Neurogliovascular unit after cerebral ischemia: is the vascular wall a pharmacological target.
Ischemic stroke induces drastic alterations of the functions of the neurogliovascular unit with dramatic consequences on the well-being of the patients in terms of cognitive and motor handicap. Nowadays, only very few therapeutics are available as a treatment of ischemic stroke. Ischemia is a multifactorial pathology involving different cerebral cellular components such as neurons, astrocytes and vessels working as a functional unit. Recent experimental strategy investigation involving different agents with antioxidant properties (dt-BC, stobadine) or pleiotropic effects (lipopolysaccharide, LPS) has been developed to evaluate whether the vascular wall could be considered as a potential target in neuroprotection concept.
Bastide
M
M
Laboratoire de Pharmacologie, Faculté de Médecine, 1, Place de Verdun, 59045 Lille Cedex, France. michele.bastide@univ-lille1.fr
Ouk
T
T
Plaisier
F
F
Pétrault
O
O
Stolc
S
S
Bordet
R
R
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D042783:Endothelial Cells / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D011188:Potassium / Q000378:metabolism; D051381:Rats; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control
D018696:Neuroprotective Agents; D011188:Potassium