title: Latent gallbladder carcinoma in a young adult patient with acute cholecystitis: report of a case.
abstract: Acute cholecystitis associated with gallbladder carcinoma is very rare in young patients (younger than 30 years of age). Moreover, a definitive preoperative diagnosis is difficult. A 26-year-old man was referred to our hospital with a 5-day history of right upper quadrant pain. Computed tomography and ultrasonography demonstrated an enlarged gallbladder with a diffuse thick wall and a 2-cm gallstone obstructing the cystic duct. Magnetic resonance cholangiopancreatography showed no evidence of an anomalous pancreaticobiliary junction. The patient showed an elevation in the white blood cell count, serum C-reactive protein, and alkaline phosphate; however, total bilirubin, alanine aminotransferase, and tumor markers including carcinoembryonic antigen and carbohydrate antigen 19-9 were all within the normal ranges. The preoperative diagnosis of gallstone-induced acute cholecystitis was made and an open cholecystectomy was thus performed 2 days after admission. The macroscopic findings showed a necrotic enlarged gallbladder with a thick wall and a gallstone, but no intraluminal nodular lesion. Histologic examinations revealed well-differentiated focal adenocarcinoma in the gallbladder mucosa, but no venous, lymphatic, or perineural invasion. The postoperative course has been uneventful with no recurrence 18 months postoperatively.
authors.affiliation: Department of Surgery, Moriguchi-Ikuno Memorial Hospital, 6-17-33 Satanakamachi, Moriguchi, Osaka 570-0002, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Tanaka
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kubota
authors.forename: Sang Hum
authors.initials: SH
authors.lastname: Lee
authors.forename: Kazuki
authors.initials: K
authors.lastname: Oba
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Ikebe
authors.forename: Shoji
authors.initials: S
authors.lastname: Kubo
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Matsuyama
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D041881:Cholecystitis, Acute / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005706:Gallbladder Neoplasms / Q000473:pathology / Q000601:surgery*; D042882:Gallstones / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor