title: The 1040C/T polymorphism influencing thermal stability and activity of thrombin activatable fibrinolysis inhibitor is associated with risk for oral cancer.
abstract: No studies thus far have investigated the contribution of thrombin activatable fibrinolysis inhibitor (TAFI) to oral oncogenesis. We studied the activity-related 1040C/T polymorphism in 150 patients with oral cancer and 138 healthy controls matched by age, gender, and ethnicity. The increased-activity T allele frequency was significantly reduced in patients compared with controls (28.7% vs. 37.0%, P < 0.05). T/T homozygotes had about half the probability of developing oral cancer (O.R. 0.39, 95%C.I. 0.13-1.14), while no significant difference was observed in C/T heterozygotes. The observed prophylactic effect of increased TAFI activity might result from reduction of plasmin and inhibition of extracellular matrix dissolution.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Vas. Sofias 93 & Dim. Soutsou 1, Athens 11521, Greece. lvairakt@med.uoa.gr
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Vairaktaris
authors.forename: Christos
authors.initials: C
authors.lastname: Yapijakis
authors.forename: Emeka
authors.initials: E
authors.lastname: Nkenke
authors.forename: Stavros
authors.initials: S
authors.lastname: Vassiliou
authors.forename: Antonis
authors.initials: A
authors.lastname: Vylliotis
authors.forename: Alexander Michael
authors.initials: AM
authors.lastname: Nixon
authors.forename: Spyridoula
authors.initials: S
authors.lastname: Derka
authors.forename: Vasilis
authors.initials: V
authors.lastname: Ragos
authors.forename: Sofia
authors.initials: S
authors.lastname: Spyridonidou
authors.forename: Christos
authors.initials: C
authors.lastname: Tsigris
authors.forename: Friedrich W
authors.initials: FW
authors.lastname: Neukam
authors.forename: Efstratios
authors.initials: E
authors.lastname: Patsouris
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D025901:Carboxypeptidase B2 / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005858:Germany; D006115:Greece; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D025901:Carboxypeptidase B2