title: [Clinical significance of AFP-L3 variants determined by micro centrifugal column].
abstract: OBJECTIVE
  To evaluate the clinical significance of AFP-L3 in patients with hepatocellular carcinoma.
  
  
  METHODS
  Serum AFP-L3 variants were separated by micro centrifugal column, and detected by chemiluminescence.
  
  
  RESULTS
  AFP and AFP-L3 levels were higher in patients with hepatocellular carcinoma than those in patients with chronic hepatitis (P<0.001); as a diagnostic target, the sensitivity and specificity of AFP-L3 were 72.3 percent and 97.2 percent, respectively. Eight patients with hepatitis have higher AFP-L3, but none of them were found with carcinoma by CT three months later.
  
  
  CONCLUSIONS
  AFP-L3 is very useful in the diagnosis of patients with hepatocellular carcinoma.
authors.affiliation: The 3rd People's Hospital of Changzhou, Changzhou 213001, China. wyz0003@163.com
authors.forename: Yong-zhong
authors.initials: YZ
authors.lastname: Wang
authors.forename: Li-bo
authors.initials: LB
authors.lastname: Luo
authors.forename: Guo-xiang
authors.initials: GX
authors.lastname: Wu
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Ruan
authors.forename: Xiang-ke
authors.initials: XK
authors.lastname: Pu
authors.forename: Shuang-rong
authors.initials: SR
authors.lastname: Hang
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis*; D002498:Centrifugation; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D000509:alpha-Fetoproteins / Q000032:analysis* / Q000302:isolation & purification
chemical_list: D000509:alpha-Fetoproteins