title: COX-1 and -2 activity of rose hip.
abstract: The objective of this study was to investigate whether the clinically observed efficacy of rose hip in the treatment of osteoarthritis is due to inhibition of cyclooxygenase-1 and -2. Water, methanol, dichloromethane and hexane extracts of rose hip were tested for in vitro COX-1 and 2 activity. The organic solvent extracts showed good inhibition of both COX-1 and 2. The methanol extract was most active in both assays with IC(50) values of 12 microg/mL for COX-1 and 19 microg/mL for COX-2. The clinically observed effect might be due to inhibition of cyclooxygenase.
authors.affiliation: Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, 2100 Copenhagen, Denmark. ankj@farma.ku.dk
authors.forename: A K
authors.initials: AK
authors.lastname: Jäger
authors.forename: I M S
authors.initials: IM
authors.lastname: Eldeen
authors.forename: J
authors.initials: J
authors.lastname: van Staden
mesh_terms: D052246:Cyclooxygenase 2 Inhibitors / Q000032:analysis*; D005638:Fruit / Q000737:chemistry*; D010003:Osteoarthritis / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use; D027826:Rosa / Q000737:chemistry*
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D010936:Plant Extracts