[Glial tumors of the brain: current aspects of the immunopathogenesis and immunogenodiagnosis].
Glioblastoma growth is a genetically regulated process. Loss or inactivation of genes - tumor suppressors may give rise to tumors and their progression. Glioblastoma multiforme is followed by a number of genetic breakages. Expression of a number of genes may affect the prognosis of the disease and tumor sensitivity to chemotherapy. Comprehensive studies of glioblastomas showed that there were at least two immunologic phenotypes: 1) that with a picture of pronounced immunodeficiency and 2) that without obvious immunodeficiency. This should be considered when elaborating present-day programs of geno- and immunodiagnosis, as well as clinicoimmunological criteria for the treatment of these tumors.
Anan'eva
I I
II
Malkarov
M S
MS
Korsakova
N A
NA
Dorofeev
A E
AE
Kachkov
I A
IA
Suchkov
S V
SV
Balkanov
A S
AS
D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000473:pathology; D005909:Glioblastoma / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000473:pathology; D006801:Humans; D007125:Immunogenetics; D007159:Immunologic Tests; D017628:Microglia / Q000276:immunology / Q000473:pathology