[Association among lipids, leptin and leptin receptor polymorphisms with risk of breast cancer].
OBJECTIVE
To evaluate the association between serum level of leptin and leptin receptor gene (LEPR) polymorphism and patients with breast cancer.


METHODS
LEPR G1n223Arg polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 94 patients with breast cancer and 128 healthy controls. The level of leptin were analyzed by enzyme linked immunosorbent assay.


RESULTS
In univariate regression analyses, we found serum level of leptin and LEPR Gin223Arg genotype polymorphism were significantly higrer than those of the controls (P < 0.05-0.001, respectively). Through multivariable analyses, we found that increased risk estimates for breast cancer were among those with leptin level (OR = 1.53, 95% CI: 1.13-2.07, P = 0.006), LEPR Gin223Arg genotype (OR = 4.87, 95%CI:1.30-18.22, P = 0.019), WHR (OR = 3.68, 95% CI: 1.34-10.11, P = 0.011).


CONCLUSIONS
Results from this study suggested that LEPR Gln233Agr polymorphism, the elevated WHR and serum level of leptin might be correlated with increased risk of breast cancer.
Han
Cun-zhi
CZ
Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China.
Shi
Jing
J
Du
Li-li
LL
Jing
Jie-xian
JX
Zhao
Xian-wen
XW
Tian
Bao-guo
BG
Tian
Fu-guo
FG
Liu
Xiu-ying
XY
Zhang
Zhong-shu
ZS
Zhang
Jin
J
D001943:Breast Neoplasms / Q000097:blood* / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D011110:Polymorphism, Genetic; D054411:Receptors, Leptin / Q000235:genetics*; D012306:Risk
C515448:LEPR protein, human; D020738:Leptin; D008055:Lipids; D054411:Receptors, Leptin