title: Evidence of immune tolerance to blood group antigens in a case of ABO-incompatible pediatric liver transplantation.
abstract: In a 12-year-old patient with blood group O, who had received a partial liver graft 10 years ago from his father with blood group A, the levels of anti-A-specific antibodies (Abs) were persistently undetectable after the transplantation, while the levels of anti-B-specific Abs gradually increased and attained a plateau. Peripheral blood mononuclear cells (PBMCs) from this patient were engrafted into NOD/SCID mouse in order to investigate the immune response to donor-type blood group antigens. Even after sensitization with blood group-A erythrocytes, no anti-A Abs were detected in the serum samples of the mouse that received PBMCs from the blood group-O recipient of group-A liver allograft, however, immunoglobulins specific for antigens other than the A antigens were produced. Thus, we provide a possible evidence of immune tolerance to blood group antigens in this ABO-incompatible pediatric liver transplantation.
authors.affiliation: Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. hohdan@hiroshima-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Ohdan
authors.forename: W
authors.initials: W
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Irei
authors.forename: Y
authors.initials: Y
authors.lastname: Fuchimoto
authors.forename: H
authors.initials: H
authors.lastname: Egawa
authors.forename: T
authors.initials: T
authors.lastname: Asahara
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D001656:Biliary Atresia / Q000601:surgery; D001787:Blood Group Incompatibility / Q000097:blood / Q000276:immunology* / Q000473:pathology; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007150:Immunohistochemistry; D016031:Liver Transplantation / Q000276:immunology* / Q000473:pathology; D008297:Male
chemical_list: D000017:ABO Blood-Group System