title: [HIV infection in children in Poland - clinical advancement at time of diagnosis].
abstract: At the end of 2006, there were about 130 children with confirmed HIV infection in Poland, 90% of them being infected vertically.
  
  
  OBJECTIVE
  to present the causes, the diagnostic procedure of HIV infection and the assessment of clinical staging at diagnosis of vertical infection in a child.
  
  
  METHODS
  between 1987-2006 there were 86 HIV infected children (45 male, 41 female) treated in our Department. 78 children had been infected vertically, 8 by other route. Reasons for HIV testing in children and clinical staging at diagnosis were analysed in vertically infected children. The patients were divided into two groups: I - diagnosed because of clinical signs and symptoms, II - because of knowledge of HIV positive status in family members.
  
  
  RESULTS
  there were 22/79 children in group I and 56/79 in group II. Vertical HIV infection diagnosis was confirmed at the age from 1 month to 11 years, the mean age was: 26 months - in group I, 25 months - in group II. During the first year of life HIV infection was diagnosed in 36 children (33% of them having AIDS, 36% severe immunodeficiency), at the age of 12-35 months in 22 children (23% of them having AIDS, 32% severe immunodeficiency) and above 35 months in 20 children (15% of them having AIDS, 35% severe immunodeficiency), respectively. Children diagnosed because of clinical manifestations were more likely to have AIDS (p<0.01) and severe immunodeficiency (p<0.07).
  
  
  CONCLUSIONS
  early diagnosis in children relies on the knowledge on the mother's HIV infection positive status. In Poland vertical HIV infection diagnosis is established late (mean: above 2 years), often at the advanced stage of the disease.
authors.affiliation: Klinika Chorób Zakaźnych Wieku Dzieciecego, Akademia Medyczna, ul. Wolska 37, 01-201 Warszawa, Poland. sabinadobosz@wp.pl
authors.forename: Sabina
authors.initials: S
authors.lastname: Dobosz
authors.forename: Magdalena
authors.initials: M
authors.lastname: Marczyńska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szczepańska-Putz
authors.forename: Jolanta
authors.initials: J
authors.lastname: Popielska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Ołdakowska
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000453:epidemiology; D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000453:epidemiology; D000163:Acquired Immunodeficiency Syndrome / Q000151:congenital / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D000328:Adult; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D019247:HIV Wasting Syndrome / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008297:Male; D011044:Poland / Q000453:epidemiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000175:diagnosis* / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors