title: Changes in hematological and serum biochemical values in jundiá Rhamdia quelen due to sub-lethal toxicity of cypermethrin.
abstract: Jundiá (Rhamdia quelen, Quoy and Gaimard), a South American teleostean fish, was exposed to sub-lethal concentrations of cypermethrin (30% and 45% of the 48-h LC(50) value of 0.265 ppm) for 2, 4 or 8 days. Serum biochemical and hematological values and behavioral changes were studied. The 30% LC(50), 0.08 ppm, produced significant increases in Mg(2+), P, K(+), creatinine, urea, glucose, cholesterol, aspartate aminotransferase and alkaline phosphatase levels, and reduction in total proteins and triglycerides in serum. The 45% LC(50), 0.12 ppm, produced significant increase in Na(+), Mg(2+), P, K(+), creatinine, urea, glucose, cholesterol, and alkaline phosphatase, and reduction in triglycerides and alanine aminotransferase levels in serum. At this concentration, the fish showed behavior changes such as hyper-excitability, asphyxia, and widening of mouth and operculum. The hematological values remained normal, except for hemoglobin concentrations and the mean corpuscular hemoglobin concentration, which increased with exposure to 0.08 ppm and 0.12 ppm cypermethrin. Results of the present work show that biochemical analysis of serum can be useful to detect incipient cypermethrin intoxication of the shoal.
authors.affiliation: Laboratório de Endocrinologia Experimental, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Sarmento Leite, 500, CEP 90050 170, Porto Alegre, RS, Brazil.
authors.forename: Adriana
authors.initials: A
authors.lastname: Borges
authors.forename: Luciana V
authors.initials: LV
authors.lastname: Scotti
authors.forename: Daniele R
authors.initials: DR
authors.lastname: Siqueira
authors.forename: Rebeca
authors.initials: R
authors.lastname: Zanini
authors.forename: Fernanda do
authors.initials: Fd
authors.lastname: Amaral
authors.forename: Daiane F
authors.initials: DF
authors.lastname: Jurinitz
authors.forename: Guillermo F
authors.initials: GF
authors.lastname: Wassermann
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D002397:Catfishes / Q000097:blood* / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D007928:Lethal Dose 50; D011722:Pyrethrins / Q000633:toxicity*; D023382:Toxicity Tests, Acute; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D006454:Hemoglobins; D011722:Pyrethrins; D014874:Water Pollutants, Chemical; C017160:cypermethrin