title: Subsequent therapeutic options and outcome in couples who fail to fertilize despite in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).
abstract: OBJECTIVE
  Failed fertilization with ICSI in women having at least five mature oocytes retrieved is uncommon. The present study evaluated 19 such patients to determine--based on this outcome--what option they would choose next and what the outcome would be.
  
  
  METHODS
  The study requirements included females age < or = 43 and use of ejaculated sperm.
  
  
  RESULTS
  Five of 19 women (26.3%) had severe oligoasthenozoospermia. Options chosen were 1) donor egg (n = 3), 2) donor embryo (n = 1), 3) donor sperm (n = 1), 4) treatment cessation (n = 3), 5) resuming IVF-ET and ICSI (n = 11). Live deliveries occurred in 1) (n = 2), 2) (n = 1), and 5) (n = 4).
  
  
  CONCLUSIONS
  When faced with failed fertilization with ICSI a small majority of women (11/19, 57.9%) chose to still try with their own gametes and some succeeded (36.3%). These data may be helpful in counseling couples who fail fertilization despite IVF with ICSI in making a decision as to their next therapeutic choice.
authors.affiliation: The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA.
authors.forename: D
authors.initials: D
authors.lastname: Horwath
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.forename: B
authors.initials: B
authors.lastname: Katsoff
authors.forename: J
authors.initials: J
authors.lastname: Amui
authors.forename: D
authors.initials: D
authors.lastname: Brasile
mesh_terms: D000328:Adult; D003376:Counseling; D036861:Delivery, Obstetric; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007248:Infertility, Male / Q000628:therapy*; D007316:Insemination, Artificial, Heterologous; D008297:Male; D010063:Ovum / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000002:abnormalities; D016896:Treatment Outcome