title: Idiopathic yellow nail syndrome successfully treated with OK-432.
abstract: A 70-year-old female presented with yellow discoloration of the nail beds of all fingers and toes, as well as bilateral pleural effusions. The patient was diagnosed as having the yellow nail syndrome based on the triad of yellow nails, lymphedema, and pleural effusions. The patient's intractable bilateral pleural effusion was treated with pleurodesis using OK-432. The treatment prevented the accumulation of pleural fluid for a long period of time. Pleural effusion associated with yellow nail syndrome is thought to be difficult to treat; however, this patient's excellent clinical course suggests that pleurodesis with OK-432 could be used to treat the disease in the future.
authors.affiliation: Department of Respiratory Medicine, Toho University Ohashi Medical Center, Tokyo. shore@oha.toho-u.ac.jp
authors.forename: Toru
authors.initials: T
authors.lastname: Yamagishi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hatanaka
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kamemura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakazawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirano
authors.forename: Norio
authors.initials: N
authors.lastname: Kodaka
authors.forename: Atsuo
authors.initials: A
authors.lastname: Miura
authors.forename: Asako
authors.initials: A
authors.lastname: Kitahara
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sawata
authors.forename: Kimio
authors.initials: K
authors.lastname: Hosaka
authors.forename: Ken
authors.initials: K
authors.lastname: Sanno
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008209:Lymphedema / Q000175:diagnosis / Q000628:therapy*; D009260:Nail Diseases / Q000175:diagnosis / Q000628:therapy*; D010844:Picibanil / Q000008:administration & dosage*; D010859:Pigmentation Disorders / Q000175:diagnosis / Q000628:therapy*; D010996:Pleural Effusion / Q000175:diagnosis / Q000628:therapy*; D018700:Pleurodesis; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D010844:Picibanil