Pd-C-induced catalytic transfer hydrogenation with triethylsilane.
In situ generation of molecular hydrogen by addition of triethylsilane to palladium-charcoal catalyst results in rapid and efficient reduction of multiple bonds, azides, imines, and nitro groups, as well as benzyl group and allyl group deprotection under mild, neutral conditions.
Mandal
Pijus K
PK
Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030, USA.
McMurray
John S
JS
D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012821:Silanes / Q000737:chemistry*
D012821:Silanes; C512918:triethylsilane; D006859:Hydrogen