title: Pharmacokinetics of enrofloxacin and flunixin meglumine and interactions between both drugs after intravenous co-administration in healthy and endotoxaemic rabbits.
abstract: The purpose of this study was to determine the pharmacokinetics and possible interactions of enrofloxacin (ENR) and flunixin meglumine (FM) in healthy rabbits and in rabbits where endotoxaemia had been induced by administering Escherichia coli lipopolysaccharide (LPS). Six male adult New Zealand White rabbits were used for the study. In Phase I, FM (2.2 mg/kg) and ENR (5 mg/kg) were given simultaneously as a bolus intravenous (IV) injection to each healthy rabbit. After a washout period, Phase II consisted of purified LPS administered as an IV bolus injection, then FM and ENR. LPS produced statistically significant increases in some serum biochemical concentrations. After the drugs were co-administered, the kinetic parameters of FM were not significantly different in healthy compared to endotoxaemic rabbits. It is concluded that ENR and FM could be co-administered to rabbits to treat endotoxaemia as no negative interaction was observed between the pharmacokinetics of both drugs.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, 42031 Konya, Turkey. melmas@selcuk.edu.tr
authors.forename: Muammer
authors.initials: M
authors.lastname: Elmas
authors.forename: Enver
authors.initials: E
authors.lastname: Yazar
authors.forename: Kamil
authors.initials: K
authors.lastname: Uney
authors.forename: Ayşe
authors.initials: A
authors.lastname: Er Karabacak
authors.forename: Bünyamin
authors.initials: B
authors.lastname: Traş
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000493:pharmacokinetics; D019540:Area Under Curve; D001774:Blood Chemical Analysis / Q000662:veterinary; D003002:Clonixin / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D004347:Drug Interactions; D019446:Endotoxemia / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D011817:Rabbits / Q000378:metabolism*; D011897:Random Allocation
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D024841:Fluoroquinolones; D008070:Lipopolysaccharides; D000077422:Enrofloxacin; C014558:flunixin meglumine; D003002:Clonixin