title: Anxiety and depression in patients with gastrointestinal cancer: does knowledge of cancer diagnosis matter?
abstract: BACKGROUND
  Gastrointestinal cancer is the first leading cause of cancer related deaths in men and the second among women in Iran. An investigation was carried out to examine anxiety and depression in this group of patients and to investigate whether the knowledge of cancer diagnosis affect their psychological distress.
  
  
  METHODS
  This was a cross sectional study of anxiety and depression in patients with gastrointestinal cancer attending to the Tehran Cancer Institute. Anxiety and depression was measured using the Hospital Anxiety and Depression Scale (HADS). This is a widely used valid questionnaire to measure psychological distress in cancer patients. Demographic and clinical data also were collected to examine anxiety and depression in sub-group of patients especially in those who knew their cancer diagnosis and those who did not.
  
  
  RESULTS
  In all 142 patients were studied. The mean age of patients was 54.1 (SD = 14.8), 56% were male, 52% did not know their cancer diagnosis, and their diagnosis was related to esophagus (29%), stomach (30%), small intestine (3%), colon (22%) and rectum (16%). The mean anxiety score was 7.6 (SD = 4.5) and for the depression this was 8.4 (SD = 3.8). Overall 47.2% and 57% of patients scored high on both anxiety and depression. There were no significant differences between gender, educational level, marital status, cancer site and anxiety and depression scores whereas those who knew their diagnosis showed a significant higher degree of psychological distress [mean (SD) anxiety score: knew diagnosis 9.1 (4.2) vs. 6.3 (4.4) did not know diagnosis, P < 0.001; mean (SD) depression score: knew diagnosis 9.1 (4.1) vs. 7.9 (3.6) did not know diagnosis, P = 0.05]. Performing logistic regression analysis while controlling for demographic and clinical variables studied the results indicated that those who knew their cancer diagnosis showed a significant higher risk of anxiety [OR: 2.7, 95% CI: 1.1-6.8] and depression [OR: 2.8, 95% CI: 1.1-7.2].
  
  
  CONCLUSIONS
  Psychological distress was higher in those who knew their cancer diagnosis. It seems that the cultural issues and the way we provide information for cancer patients play important role in their improved or decreased psychological well-being.
authors.affiliation: Department of Psychology, Faculty of Humanity Studies, Shahed University, Tehran, Iran. tavoli1@yahoo.com <tavoli1@yahoo.com>
authors.forename: Azadeh
authors.initials: A
authors.lastname: Tavoli
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Mohagheghi
authors.forename: Ali
authors.initials: A
authors.lastname: Montazeri
authors.forename: Rasool
authors.initials: R
authors.lastname: Roshan
authors.forename: Zahra
authors.initials: Z
authors.lastname: Tavoli
authors.forename: Sepideh
authors.initials: S
authors.lastname: Omidvari
mesh_terms: D001007:Anxiety / Q000453:epidemiology*; D015984:Causality; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology*; D030881:Disclosure / Q000706:statistics & numerical data*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology* / Q000523:psychology*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis