title: An unprecedented Pd-catalyzed, water-promoted sequential oxidative aminocarbonylation-cyclocarbonylation process leading to 2-oxazolidinones.
abstract: An unprecedented, PdI2-catalyzed, sequential oxidative aminocarbonylation-cyclocarbonylation process, leading to 2-oxazolidinone derivatives 3 in good to excellent yields starting from readily available alpha,alpha-disubstituted 2-ynylamines 1 and secondary amines 2, is reported. In the case of an alpha-monosubstituted substrate, the initially formed 2-oxazolidinone derivative underwent shift of the double bond to give a 3H-oxazol-2-one derivative in excellent isolated yield.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università della Calabria, 87036 Arcavacata di Rende (Cosenza), Italy. b.gabriele@unical.it
authors.forename: Bartolo
authors.initials: B
authors.lastname: Gabriele
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Plastina
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Salerno
authors.forename: Raffaella
authors.initials: R
authors.lastname: Mancuso
authors.forename: Mirco
authors.initials: M
authors.lastname: Costa
mesh_terms: D002384:Catalysis; D023303:Oxazolidinones / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D023303:Oxazolidinones; D014867:Water; D010165:Palladium