title: Changes of human B and B-1a peripheral blood lymphocytes with age.
abstract: In 2057 consecutive subjects admitted to the Department of Pathology, Section of Immunology of the Verona University Hospital, CD19+ and CD5/CD19 double positive cells were determined to assess the behaviour of total peripheral B-lymphocytes and B-1a (CD5+) compartments in humans during aging. We show that the absolute number of total B lymphocytes increases about three-fold from the baseline conditions in the first year of life and progressively decreases until adult age. A slower decrease was detected from the adult age onwards. A similar behaviour has been observed within the B-1a subset of B-lymphocytes, although the decrease after the adult age seems more pronounced. Possible physiological explanations and/or implications for the disease states are taken into account.
authors.affiliation: Section of Hematology, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy. dino.veneri@univr.it
authors.forename: Dino
authors.initials: D
authors.lastname: Veneri
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
authors.forename: Antonio
authors.initials: A
authors.lastname: Vella
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tridente
authors.forename: Gianpietro
authors.initials: G
authors.lastname: Semenzato
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pizzolo
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ortolani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D018941:Antigens, CD19 / Q000032:analysis; D016175:B-Lymphocyte Subsets / Q000166:cytology*; D018956:CD5 Antigens / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged
chemical_list: D018941:Antigens, CD19; D018956:CD5 Antigens