BK virus-induced tubulointerstitial nephritis in a child with acute lymphoblastic leukemia.
We report a case of BK virus-induced tubulointerstitial nephritis in a child with acute lymphoblastic leukemia. Primary BK virus infection was exacerbated by chemotherapy-induced immunodeficiency. Careful administration of chemotherapy and anti-viral therapy prevented further damage. This diagnosis should be considered in children who experience renal dysfunction during cancer treatment.
Inaba
Hiroto
H
Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. hiroto.inaba@stjude.org
Jones
Deborah P
DP
Gaber
Lillian W
LW
Shenep
Jerry L
JL
Call
Sandra K
SK
Pui
Ching-Hon
CH
Razzouk
Bassem I
BI
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001739:BK Virus / Q000302:isolation & purification*; D001707:Biopsy, Needle; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007677:Kidney Function Tests; D009395:Nephritis, Interstitial / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D027601:Polyomavirus Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D018570:Risk Assessment; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy
D000998:Antiviral Agents