Iron signaling and oxidant damage.
In this brief essay we discuss the interrelationship between the cellular signaling effects induced by extracellular and intracellular ROS and nitric oxide in the context of doxorubicin (DOX) toxicity.
Kalyanaraman
Balaraman
B
Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, USA. balarama@mcw.edu
D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D004317:Doxorubicin / Q000633:toxicity; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity; D007501:Iron / Q000502:physiology*; D009569:Nitric Oxide / Q000502:physiology; D016877:Oxidants / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D011990:Receptors, Transferrin / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D000903:Antibiotics, Antineoplastic; D016877:Oxidants; D011990:Receptors, Transferrin; D009569:Nitric Oxide; D004317:Doxorubicin; D006861:Hydrogen Peroxide; D007501:Iron