title: Predictors of acute treatment response among patients with cluster headache.
abstract: BACKGROUND
  Oxygen and triptans are drugs of first choice to abort cluster headache attacks. However, clinical predictors of treatment response are unavailable.
  
  
  OBJECTIVE
  We aimed to identify predictors of acute treatment response among patients with cluster headache.
  
  
  METHODS
  We investigated 246 cluster headache patients with available information on personal, headache, and lifestyle characteristics as well as effectiveness of acute medication use. We used logistic regression models to identify potential predictors of triptan and oxygen response.
  
  
  RESULTS
  Triptans were effective in 137 of the 191 users and oxygen in 134 of the 175 users. We only identified increasing age (OR 0.96, 95% CI 0.93-0.99; P= .013) as a negative predictor for triptan response, while nausea/vomiting (OR 0.41, 95% CI 0.18-0.91; P= .029) and restlessness (OR 0.09, 95% CI 0.01-0.66; P= .019) were negative predictors of oxygen response.
  
  
  CONCLUSIONS
  Few clinical features seem to predict treatment nonresponse in cluster headache. More refined studies aiming at physiological and genetic characteristics seem promising in the future.
authors.affiliation: Department of Neurology, University of Duisberg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Schürks
authors.forename: Dieter
authors.initials: D
authors.lastname: Rosskopf
authors.forename: Janete
authors.initials: J
authors.lastname: de Jesus
authors.forename: Mira
authors.initials: M
authors.lastname: Jonjic
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Diener
authors.forename: Tobias
authors.initials: T
authors.lastname: Kurth
mesh_terms: D000328:Adult; D003027:Cluster Headache / Q000188:drug therapy* / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D014363:Tryptamines / Q000627:therapeutic use*
chemical_list: D014363:Tryptamines