Toward the total synthesis of spirastrellolide A. Part 3: intelligence gathering and preparation of a ring-expanded analogue.
Different methods for the formation of the C.25-C.26 bond of spirastrellolide A () are evaluated that might qualify for the end game of the projected total synthesis, with emphasis on metathetic ways to forge the macrocyclic frame.
Fürstner
Alois
A
Max-Planck-Institut für Kohlenforschung, D-45470, Mülheim/Ruhr, Germany. fuerstner@mpi-muelheim.mpg.de
Fasching
Bernhard
B
O'Neil
Gregory W
GW
Fenster
Michaël D B
MD
Godbout
Cédrickx
C
Ceccon
Julien
J
D003500:Cyclization; D007202:Indicators and Reagents / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis*; D013141:Spiro Compounds
D007202:Indicators and Reagents; D018942:Macrolides; D013141:Spiro Compounds; C475125:spirastrellolide A