title: Proinflammatory cytokine single nucleotide polymorphisms in nasal polyposis.
abstract: OBJECTIVE
  To investigate the association between nasal polyposis (NP) and single nucleotide polymorphisms of the proinflammatory cytokines IL (interleukin) 1alpha (the IL1A gene), IL-1beta (the IL1B gene), and tumor necrosis factor alpha (the TNFA gene).
  
  
  METHODS
  Prospective case-control trial.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Eighty-two patients with NP and 106 healthy volunteers without sinonasal disease.
  
  
  METHODS
  Genotypes of IL1A (4845G, 4845T), IL1B (-511C, -511T) and TNFA (-238G, -238A and -308G, -308A) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.
  
  
  RESULTS
  The 4845 GT and 4845 TT genotypes of the IL1A gene were associated with NP (P<.05). The frequency of the -511 CC genotype of the IL1B gene was significantly higher in patients with NP than in controls (P=.01). The frequency of the -511 CT genotype of IL1B was significantly higher (P=.01) in the controls than in the patients with NP. The -238 AA genotype of the TNFA gene was higher in the patients with NP than in the controls (P=.05). There was a significantly high risk of susceptibility to NP in patients with the -308 GA genotype of TNFA (P=.001). None of the genotypes of the proinflammatory cytokines were related to sex, the presence of atopy, asthma, or aspirin intolerance (P>.05).
  
  
  CONCLUSIONS
  The IL1A (4845 GT and 4845 TT), IL1B (-511 CC), and TNFA (-238 AA and -308 GA) genotypes were associated with susceptibility to NP in our study population.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Baskent University Konya Teaching and Research Center, Saray Caddesi No. 1, Selcuklu Konya, Ankara, Turkey. selimerbek@gmail.com
authors.forename: Selim S
authors.initials: SS
authors.lastname: Erbek
authors.forename: Erkan
authors.initials: E
authors.lastname: Yurtcu
authors.forename: Seyra
authors.initials: S
authors.lastname: Erbek
authors.forename: F Belgin
authors.initials: FB
authors.lastname: Atac
authors.forename: Feride I
authors.initials: FI
authors.lastname: Sahin
authors.forename: Ozcan
authors.initials: O
authors.lastname: Cakmak
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016207:Cytokines / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies
chemical_list: D016207:Cytokines