title: Yttrium 90 microsphere selective internal radiation treatment of hepatic colorectal metastases.
abstract: OBJECTIVE
  To discuss the basic concepts involved in the development of yttrium 90 (Y-90) microsphere selective internal radiation treatment and review the clinical data pertaining to its application in hepatic colorectal cancer metastases.
  
  
  METHODS
  Published studies and scientific paper presentations.
  
  
  METHODS
  Randomized clinical studies and retrospective reviews.
  
  
  CONCLUSIONS
  Selective internal radiation treatment is a promising new modality in the treatment of patients with hepatic colorectal cancer metastases as part of a multimodality approach. A chemo-selective internal radiation treatment neoadjuvant approach has a potential to improve therapeutic outcomes. Clinical studies in neoadjuvant and salvage settings are needed for more concrete outcome data and design of optimal multimodality treatment strategies.
authors.affiliation: Department of Surgery, Center for Cancer Care at Goshen Health System, Goshen, IN 46526, USA. sgulec@goshenhealth.com
authors.forename: Seza A
authors.initials: SA
authors.lastname: Gulec
authors.forename: Yuman
authors.initials: Y
authors.lastname: Fong
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D008863:Microspheres; D020360:Neoadjuvant Therapy; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012004:Rectal Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes