A controlled prospective investigation of psychiatric comorbidity in temporal lobe epilepsy.
Temporal lobe epilepsy patients (n = 48) and healthy controls (n = 69) underwent structured psychiatric interview at baseline and 4 years later to characterize the course of DSM-IV Axis I disorders. Adjusting for the influence of prior psychiatric history, epilepsy subjects exhibit significantly greater risk of interval episodes of Total Axis I Disorders and Mood Disorders, indicating a poorer prognosis for these comorbidities in the context of chronic temporal lobe epilepsy.
Jones
Jana E
JE
Department of Neurology and Biostatistics, University of Wisconsin, Madison, Wisconsin 53792, USA. jejones@neurology.wisc.edu
Bell
Brian
B
Fine
Jason
J
Rutecki
Paul
P
Seidenberg
Michael
M
Hermann
Bruce
B
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D015897:Comorbidity; D035061:Control Groups; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis / Q000453:epidemiology; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors