title: Ideal body weight correlates better with engraftment after PBSC autograft than actual body weight, but is under-estimated in myeloma patients possibly due to disease-related height loss.
abstract: Stem cell dose is important in determining rate of engraftment following autograft. We show closer correlation with haematopoietic reconstitution when the CD34+ cell dose is calculated using ideal (IBW) rather than actual (ABW) body weight in 218 patients receiving peripheral blood stem cell (PBSC) autograft for haematological malignancy. ABW was 21% greater than IBW thus the median CD34+ dose of 5.0 x 10(6)/kg (ABW) rose to 6.1 x 10(6)/kg when calculated by IBW. Neutrophils reached 0.5 x 10(9)/l in 11 days (range 8-21), while platelets reached 20 x 10(9)/l unsupported in 12 days (range 7-38). For both neutrophil and platelet engraftment, a greater inverse correlation was seen when IBW was used to calculate stem cell dose (r2=0.082 vs r2=0.104 for neutrophils and r2=0.085 vs r2=0.135 for platelets). Those non-myeloma patients who failed to achieve a CD34+ dose of 4 x 10(6) cells/kg by ABW but did so by IBW achieved neutrophil and platelet engraftment not significantly different from those who achieved that stem cell dose by both methods. This was not confirmed in patients treated for myeloma, possibly owing to inaccurate IBW in patients with skeletal height loss. We confirm that calculation of CD34+ cell dose by IBW safely predicts engraftment for patients with haematological malignancies other than myeloma undergoing PBSC autograft.
authors.affiliation: Department of Clinical Apheresis, Scottish National Blood Transfusion Service, Glasgow Royal Infirmary, Scotland, UK. petermaclean@nhs.net
authors.forename: P S
authors.initials: PS
authors.lastname: Maclean
authors.forename: A N
authors.initials: AN
authors.lastname: Parker
authors.forename: I G
authors.initials: IG
authors.lastname: McQuaker
authors.forename: A D
authors.initials: AD
authors.lastname: Clark
authors.forename: E
authors.initials: E
authors.lastname: Farrell
authors.forename: K W
authors.initials: KW
authors.lastname: Douglas
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D018952:Antigens, CD34 / Q000097:blood; D001835:Body Weight; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D007958:Leukocyte Count; D008223:Lymphoma / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000473:pathology / Q000628:therapy*; D009504:Neutrophils; D018579:Patient Selection; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D012016:Reference Values; D012189:Retrospective Studies; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34