title: Mortality from Alzheimer's, motor neuron and Parkinson's disease in relation to magnetic field exposure: findings from the study of UK electricity generation and transmission workers, 1973-2004.
abstract: BACKGROUND
  There are a number of reports linking magnetic field exposure to increased risks of Alzheimer's disease and motor neuron disease.
  
  
  METHODS
  The mortality experienced by a cohort of 83 997 employees of the former Central Electricity Generating Board of England and Wales was investigated for the period 1973-2004. All employees were employed for at least six months with some employment in the period 1973-82. Computerised work histories were available for 79 972 study subjects for the period 1971-93. Information on job and facility (location) were used to estimate exposures to magnetic fields. Two analytical approaches were used to evaluate risks, indirect standardisation (n = 83 997) and Poisson regression (n = 79 972).
  
  
  RESULTS
  Based on serial mortality rates for England and Wales, deaths from Alzheimer's disease and motor neuron disease were unexceptional. There was an excess of deaths from Parkinson's disease of borderline significance. No statistically significant trends were shown for risks of any of these diseases to increase with lifetime cumulative exposure to magnetic fields (RR per 10 μT-y: Alzheimer's disease 1.10 (95% CI 0.90 to 1.33); motor neuron disease 1.06 (95% CI 0.86 to 1.32); Parkinson's disease 0.88 (95% CI 0.74 to 1.05))
  
  
  CONCLUSIONS
  There is no convincing evidence that UK electricity generation and transmission workers have suffered increased risks from neurodegenerative diseases as a consequence of exposure to magnetic fields.
authors.affiliation: Institute of Occupational and Environmental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. T.M.Sorahan@bham.ac.uk
authors.forename: T
authors.initials: T
authors.lastname: Sorahan
authors.forename: L
authors.initials: L
authors.lastname: Kheifets
mesh_terms: D000544:Alzheimer Disease / Q000401:mortality*; D015331:Cohort Studies; D004560:Electricity; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D060526:Magnetic Fields / Q000009:adverse effects*; D008297:Male; D009046:Motor Neurons / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000401:mortality*; D009784:Occupational Diseases / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects*; D010300:Parkinson Disease / Q000401:mortality*; D011210:Power Plants; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology; D014852:Wales / Q000453:epidemiology