title: [Cyanosis and dyspnoea in orthostasis].
abstract: METHODS
  A 69-year-old female patient was admitted to a hospital for severe dyspnoea. It was conspicuous that shortness of breath and cyanosis only occurred in upright and completely disappeared in the supine position. This finding was objectified by pulse oximetry which demonstrated a decrease of arterial oyxgen saturation from 96 % in the supine to 86 % in the upright position.
  
  
  METHODS
  After exclusion of other diseases the diagnosis of platypnoe- orthodeoxia syndrome as a result of a patent foramen ovale (PFO) was established.
  
  
  METHODS
  Cardiac catheterization in the upright and the supine position documented a high-grade right-to-left shunt of 31 % proportionally to systemic circulatory volume in the upright position with subsequent critical reduction of pulmonary perfusion to 1.4 l/min/m (2) (reference value > 2.2 l/min/m (2)) as the cause of dyspnoea. Catheter-based occlusion of the PFO was chosen as causal treatment modality. After that arterial oxygen saturation remained constant at 95 % in the supine and upright position and symptoms improved.
  
  
  CONCLUSIONS
  Platypnoe-othodeoxia syndrome is a very rare syndrome but it can be substantiated by pathognomonic case history, clinical examination and simple machine-aided examinations. With a causative PFO a causal and save therapy is available.
authors.affiliation: Universitätsklinikum, Klinik für Kardiologie, Düsseldorf, Germany.
authors.forename: F C
authors.initials: FC
authors.lastname: Schoebel
authors.forename: A J
authors.initials: AJ
authors.lastname: Peters
authors.forename: T W
authors.initials: TW
authors.lastname: Jax
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization / Q000379:methods*; D003490:Cyanosis / Q000209:etiology*; D004417:Dyspnea / Q000209:etiology*; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D010092:Oximetry; D011187:Posture; D017410:Practice Guidelines as Topic; D013577:Syndrome; D016896:Treatment Outcome