[Effect of glucosamine sulfate on the analgesic and ulcerogenic activity of ketoprofen].
The effect of glucosamine sulfate on the analgesic properties and ulcerogenic action of ketoprofen has been experimentally studied in the course of drug adminstration in laboratory animals in comparison to the ketoprofen monotherapy. An analysis of the results shows that the combined application of glucosamine sulfate with ketoprofen produces a twofold increase in the analgesic activity of ketoprofen and decreases the drug-induced damage of the stomach mucous membrane. These effects are especially pronounced for the following ratio of components: ketoprofen, 16 or 24 mg/kg; glucosamine sulfate, 125 mg/kg.
Violin
B V
BV
Kompantsev
D V
DV
Pogorelyĭ
V E
VE
Makarova
L M
LM
Kompantseva
E V
EV
Leonova
V N
VN
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D005944:Glucosamine / Q000494:pharmacology*; D007660:Ketoprofen / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen; D005944:Glucosamine