title: The prevalence of food allergy: a meta-analysis.
abstract: BACKGROUND
  There is uncertainty about the prevalence of food allergy in communities.
  
  
  OBJECTIVE
  To assess the prevalence of food allergy by performing a meta-analysis according to the method of assessment used.
  
  
  METHODS
  The foods assessed were cow's milk, hen's egg, peanut, fish, shellfish, and an overall estimate of food allergy. We summarized the information in 5 categories: self-reported symptoms, specific IgE positive, specific skin prick test positive, symptoms combined with sensitization, and food challenge studies. We systematically searched MEDLINE and EMBASE for publications since 1990. The meta-analysis included only original studies. They were stratified by age groups: infant/preschool, school children, and adults.
  
  
  RESULTS
  A total of 934 articles were identified, but only 51 were considered appropriate for inclusion. The prevalence of self-reported food allergy was very high compared with objective measures. There was marked heterogeneity between studies regardless of type of assessment or food item considered, and in most analyses this persisted after age stratification. Self-reported prevalence of food allergy varied from 1.2% to 17% for milk, 0.2% to 7% for egg, 0% to 2% for peanuts and fish, 0% to 10% for shellfish, and 3% to 35% for any food.
  
  
  CONCLUSIONS
  There is a marked heterogeneity in the prevalence of food allergy that could be a result of differences in study design or methodology, or differences between populations.
  
  
  CONCLUSIONS
  We recommend that measurements be made by using standardized methods, if possible food challenge. We need to be cautious in estimates of prevalence based only on self-reported food allergy.
authors.affiliation: Division of Asthma, Allergy and Lung Biology, King's College London, London, United Kingdom.
authors.forename: Roberto J
authors.initials: RJ
authors.lastname: Rona
authors.forename: Thomas
authors.initials: T
authors.lastname: Keil
authors.forename: Colin
authors.initials: C
authors.lastname: Summers
authors.forename: David
authors.initials: D
authors.lastname: Gislason
authors.forename: Laurian
authors.initials: L
authors.lastname: Zuidmeer
authors.forename: Eva
authors.initials: E
authors.lastname: Sodergren
authors.forename: Sigurveig T
authors.initials: ST
authors.lastname: Sigurdardottir
authors.forename: Titia
authors.initials: T
authors.lastname: Lindner
authors.forename: Klaus
authors.initials: K
authors.lastname: Goldhahn
authors.forename: Jorgen
authors.initials: J
authors.lastname: Dahlstrom
authors.forename: Doreen
authors.initials: D
authors.lastname: McBride
authors.forename: Charlotte
authors.initials: C
authors.lastname: Madsen
mesh_terms: D000818:Animals; D021181:Egg Hypersensitivity / Q000453:epidemiology; D005399:Fishes / Q000276:immunology; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007073:Immunoglobulin E; D016269:Milk Hypersensitivity / Q000453:epidemiology; D021183:Peanut Hypersensitivity / Q000453:epidemiology; D015995:Prevalence; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E