[Imaging of inflammatory foci with 99m technecium labeled antimicrobial oligopeptide].
A direct method using 99mtechnecium to label the synthetic antimicrobial oligopeptide ubiquicidine with a molecular mass of 1.7 kDa has been developed. The radiochemical purity of the resultant labeled compound was more than 98%. A combination of ubiquicidine and 99mtechnecium showed stability in blood plasma. The biological study indicated that the complex was renally excreted from blood flow rapidly (the half-life is 30 min). It accumulated in the experimental inflammatory focus of laboratory animals, peaking 1-2 hours after intravenous injection when the inflammatory focus/intact tissue ratio amounted up to 2.6-3.4, which could yield satisfactory abscess scintigrams. The findings make it possible to consider ubiquicidine as a promising compound for the design of radiopharmaceutical to image inflammatory foci.
Sergienko
V B
VB
Bespalova
Zh D
ZhD
Posdeev
V V
VV
Mart'ianov
B M
BM
Sidorova
M V
MV
Kuz'min
A V
AV
Sergienko
A V
AV
D000818:Animals; D004195:Disease Models, Animal; D007275:Injections, Intravenous; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D012269:Ribosomal Proteins / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013670:Sodium Pertechnetate Tc 99m / Q000008:administration & dosage / Q000493:pharmacokinetics; D013203:Staphylococcal Infections / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism; D013210:Staphylococcus / Q000472:pathogenicity; D016896:Treatment Outcome
D019275:Radiopharmaceuticals; D012269:Ribosomal Proteins; C040469:ribosomal protein S30; D013670:Sodium Pertechnetate Tc 99m