title: A case of concomitant occurrence of struma ovarii and malignant transformation of cystic teratoma.
abstract: A 77-year-old woman received a total abdominal hysterectomy and bilateral salpingo-oophorectomy because of a tumor in the left ovary. The surgical specimen measured 8.5x4.5x4.0 cm, and the solid lesion measured 4.0x3.5x3.5 cm. The solid lesion was diagnosed as struma ovarii. The cyst wall partially comprised squamous epithelium-like and ciliated columnar epithelium-like cells. The tumorous lesion of the cyst wall revealed a poorly differentiated adenocarcinoma. Immunohistochemically, the tumor cells were positive for cytokeratin7, and were negative for cytokeratin20 and thyroid transcription factor-1. The authors diagnosed that struma ovarii and other parats coexisted as a poorly differentiated adenocarcinoma that had arisen from a mature ovarian cystic teratoma. As for the identification of the origin of adenocarcinomas arising from mature ovarian cystic teratomas, more cases need to be identified and investigated.
authors.affiliation: Second Department of Neurosurgery, Toho University School of Medicine, and Mita Hospital, Tokyo, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Saito
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hatori
authors.forename: Nozomu
authors.initials: N
authors.lastname: Murata
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Shibuya
authors.forename: Aki
authors.initials: A
authors.lastname: Mitsuda
authors.forename: Chikako
authors.initials: C
authors.lastname: Hasegawa
authors.forename: Michio
authors.initials: M
authors.lastname: Akima
authors.forename: Meiki
authors.initials: M
authors.lastname: Ikawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Nonaka
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053552:Keratin-7 / Q000235:genetics / Q000378:metabolism; D020714:Maximum Tolerated Dose; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology*; D013330:Struma Ovarii / Q000175:diagnosis / Q000473:pathology*; D013724:Teratoma / Q000175:diagnosis / Q000473:pathology*
chemical_list: D053552:Keratin-7