title: Histological and histomorphometric investigations on bone integration of rapidly resorbable calcium phosphate ceramics.
abstract: Resorbable ceramics can promote the bony integration of implants. Their rate of degradation should ideally be synchronized with bone regeneration. We report here the results of a histological study of implants with two resorbable calcium phosphate ceramic coatings: Ca(2)KNa(PO(4))(2)-(GB14) and Ca(10)[K/Na](PO(4))(7)-(602020). The results attained with these ceramic-coated implants show the benefits of these materials with regard to bioactive bone-healing stimulation, compared with uncoated implants. The GB14 ceramic coating exhibited greater bone regeneration and differentiation on its surface than the conventional hydroxyapatite coating and helped bone tissue achieve more extensive contact free of connective tissue. Not until the coating disintegrated did the histological features of GB14- and 602020-coated implants converge-both implant types were integrated into bone. Rapid disintegration of the coating material, as with 602020, supports osteoblast proliferation but has negative effects on bone mineralization. Both resorbable ceramics tested, GB14 and 602020, demonstrated bioactivity; even metal surfaces coated with these materials were populated by mature bone tissue without connective tissue after disintegration of their ceramic coating. The less rapidly degrading material, GB14, achieved better results. Degradable calcium phosphate coatings have the potential to stimulate bone regeneration. From the histological viewpoint, the resorbable ceramics examined here can be recommended as coating materials for clinical use.
authors.affiliation: Laboratory of Experimental Orthopedics, Department of Orthopedics, Martin Luther University of Halle-Wittenberg, Magdeburger Strasse 22, 06097 Halle, Germany. anke.bernstein@medizin.uni-halle.de
authors.forename: Anke
authors.initials: A
authors.lastname: Bernstein
authors.forename: Doreen
authors.initials: D
authors.lastname: Nöbel
authors.forename: Hermann O
authors.initials: HO
authors.lastname: Mayr
authors.forename: Georg
authors.initials: G
authors.lastname: Berger
authors.forename: Renate
authors.initials: R
authors.lastname: Gildenhaar
authors.forename: Jörg
authors.initials: J
authors.lastname: Brandt
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D018786:Bone Substitutes / Q000378:metabolism*; D001842:Bone and Bones / Q000502:physiology*; D002130:Calcium Phosphates / Q000378:metabolism*; D002516:Ceramics / Q000378:metabolism*; D020099:Coated Materials, Biocompatible / Q000378:metabolism; D017886:Durapatite; D005260:Female; D008297:Male; D016348:Osseointegration / Q000502:physiology*; D011817:Rabbits
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C448993:GB14N ceramic glass; D017886:Durapatite; C020243:calcium phosphate