Tolerogenic functions of human leukocyte antigen G: from pregnancy to organ and cell transplantation.
Over the past few years, the number of publications concerning the human leukocyte antigen (HLA)-G molecule, its functions, and its pathological implications has greatly increased, largely exceeding those focusing simply on fetal-maternal activity. The role of this molecule in other situations of tolerance such as transplantation, tumor dissemination, or virus infections has also been reported. In this paper, we focus our attention on the relevance of HLA-G in transplantation in the light of recent data associating regulatory T cells and HLA-G, and which provide evidence of the role of HLA-G in improving graft acceptance.
Rouas-Freiss
Nathalie
N
Service de Recherches en Hémato-Immunologie, CEA-DSV-DRM, Hôpital Saint-Louis, Institut Universitaire d'Hématologie, 1 Avenue Claude Vellefaux, 75010 Paris, France. nathalie.rouas-freiss@cea.fr
Naji
Abderrahim
A
Durrbach
Antoine
A
Carosella
Edgardo D
ED
D000818:Animals; D017690:Cell Transplantation; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D016377:Organ Transplantation; D011247:Pregnancy / Q000276:immunology*; D014181:Transplantation Immunology; D014184:Transplantation, Homologous / Q000276:immunology
D006680:HLA Antigens