title: [Role of IgE-dependent reactions in atopic dermatitis].
abstract: Atopic dermatitis is a disease of multifactorial pathogenesis.
  
  
  OBJECTIVE
  of the study was to establish the most common allergens responsible for development of atopic symptoms in children with atopic dermatitis.
  
  
  METHODS
  the study complied 36 children aged 4 months - 3 years treated in the Department of Children Allergology, Gastroenterology and Nutrition because of atopic dermatitis. With each case the patient and family history of atopy was collected and basic laboratory tests were conducted (including total IgE and specific IgE using Polly Check system).
  
  
  RESULTS
  eosinophilia was found in 11/36 children, elevated total IgE level in 16/36 and specific IgE were present in 14/36 patients. 6 patients proved to have sIgE for more then one allergen. The most commonly found allergens were animal hair, and food allergens. In 22 cases in spite of obvious clinical symptoms requiring therapy at hospital, all sIgE were negative for all tested allergens.
  
  
  CONCLUSIONS
  although estimating sIgE is commonly used in diagnosing atopic dermatitis, it may not be sufficient to establish complete diagnosis. It seems that animal hair and food allergens are mainly responsible for development of atopic dermatitis.
authors.affiliation: Klinika Alergologii, Gastroenterologii i Zywienia Dzieci III Katedry Pediatrii UM, ul. Sporna 36/50, 91-738 Łodz, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Dynowski
authors.forename: Krystyna
authors.initials: K
authors.lastname: Wasowska-Królikowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Modzelewska-Hołyńska
authors.forename: Monika
authors.initials: M
authors.lastname: Tomaszewska
authors.forename: Marzena
authors.initials: M
authors.lastname: Funkowicz
mesh_terms: D000485:Allergens / Q000145:classification / Q000276:immunology; D000818:Animals; D002415:Cats; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D003937:Diagnosis, Differential; D004285:Dogs; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000276:immunology*; D006736:Horses; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis* / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D008297:Male; D011058:Pollen / Q000276:immunology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012882:Skin Tests / Q000379:methods
chemical_list: D000485:Allergens; D007073:Immunoglobulin E