[Amyloid cardiomyopathy: a link between cardiology and hematology. A case report of positive response to standard therapy].
Cardiac involvement in primary systemic amyloidosis, due to amassing of fragments of light chains, is detected in the majority of cases. We report the case of a 56-year-old woman who came to our observation because of symptoms of congestive heart failure. Diagnosis of restrictive cardiomyopathy was made by echocardiographic examination, which showed right ventricular hypertrophy, disarray of interventricular septum and restrictive flow pattern at the mitral valve. Primary systemic amyloidosis was diagnosed by abdominal fat pad biopsy. Laboratory findings confirmed biopsy results, leading to the definite diagnosis of restrictive cardiomyopathy due to IgA kappa monoclonal gammopathy in primary systemic amyloidosis.
Petrillo
Gianluca
G
Departimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi Federico II, Napoli. gianlucapetrillo@hotmail.com
Catalano
Lucio
L
Petruzziello
Fara
F
Padula
Sergio
S
Petrillo
Claudio
C
Caso
Pio
P
D050153:Abdominal Fat / Q000276:immunology; D000686:Amyloidosis / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D001706:Biopsy; D002313:Cardiomyopathy, Restrictive / Q000150:complications* / Q000000981:diagnostic imaging / Q000276:immunology; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000209:etiology; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D008875:Middle Aged
D007145:Immunoglobulin kappa-Chains