New lipoxygenase-inhibiting constituents from Calligonum polygonoides.
Calligonolides A (1) and B (2), two new butanolides, and a new steroidal ester, 3, have been isolated from the whole plant of Calligonum polygonoides, together with four known compounds, tetracosan-4-olide, beta-sitosterol and its glucoside, and ursolic acid. Their structures were elucidated by spectroscopic and mass-spectrometric studies. Compounds 1-3 showed moderate inhibitory potential against lipoxygenase from soybean.
Yawer
Mirza Arfan
MA
International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Ahmed
Ejaz
E
Malik
Abdul
A
Ashraf
Muhammad
M
Rasool
Muhammad Azam
MA
Afza
Nighat
N
D008084:Lipoxygenase / Q000378:metabolism*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019664:Polygonaceae / Q000201:enzymology*
D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D008084:Lipoxygenase