The multicopper oxidase (CueO) and cell aggregation in Escherichia coli.
cueO encodes a periplasmic multicopper oxidase, which is known to be involved in copper homeostasis and protection against oxidative stress in Escherichia coli K12. Transcriptional profiling showed that expression of genes associated with motility was lowered in a cueO mutant while expression of genes associated with autoaggregation was elevated. Increased aggregation was correlated with increased expression of cell surface proteins antigen 43 and curli. Changes in gene expression caused by the deletion of cueO were essentially independent of SoxR and OxyR, the global regulators of oxidative stress response.
Tree
Jai J
JJ
School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Australia.
Ulett
Glenn C
GC
Hobman
Jon L
JL
Constantinidou
Chrystala
C
Brown
Nigel L
NL
Kershaw
Christopher
C
Schembri
Mark A
MA
Jennings
Michael P
MP
McEwan
Alastair G
AG
D018829:Adhesins, Bacterial / Q000235:genetics; D018830:Adhesins, Escherichia coli; D000942:Antigens, Bacterial / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D018441:Biofilms; D004926:Escherichia coli / Q000235:genetics / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000502:physiology*; D015870:Gene Expression; D020869:Gene Expression Profiling; D009154:Mutation; D010088:Oxidoreductases / Q000235:genetics / Q000502:physiology*
D018829:Adhesins, Bacterial; D018830:Adhesins, Escherichia coli; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C118376:antigen 43, E coli; C077481:Crl protein, Bacteria; D010088:Oxidoreductases; C499679:cueO protein, E coli