title: Neonatal nucleated red blood cells in infants of overweight and obese mothers.
abstract: OBJECTIVE
  The perinatal outcome of the infant of obese mother is adversely affected and in theory, may involve fetal hypoxia. We hypothesized that an index of fetal hypoxia, the neonatal nucleated red blood cell (NRBC) count, is elevated in infants of overweight and obese mothers.
  
  
  METHODS
  Absolute NRBC counts taken during the first 12 hours of life in 41 infants of overweight and obese mothers were compared to 28 controls.
  
  
  RESULTS
  Maternal body mass index and infant birthweight were significantly higher in the overweight and obese group (P < 0.01). Hematocrit, corrected white blood cell and lymphocyte counts did not differ between groups. The absolute NRBC count was higher (P = 0.01), and the platelet count lower (P = 0.05) in infants of overweight and obese mothers than in controls. In stepwise regression analysis, the absolute NRBC count in infants of overweight and obese mothers remained significantly higher even after taking into account birthweight or gestational age and Apgar scores (P < 0.02).
  
  
  CONCLUSIONS
  Infants of overweight and obese mothers have increased nucleated red blood cells at birth compared with controls. We speculate that even apparently healthy fetuses of overweight and obese mothers are exposed to a subtle hypoxemic environment.
authors.affiliation: Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, 64239, Israel.
authors.forename: Galit
authors.initials: G
authors.lastname: Sheffer-Mimouni
authors.forename: Francis B
authors.initials: FB
authors.lastname: Mimouni
authors.forename: Shaul
authors.initials: S
authors.lastname: Dollberg
authors.forename: Dror
authors.initials: D
authors.lastname: Mandel
authors.forename: Varda
authors.initials: V
authors.lastname: Deutsch
authors.forename: Yoav
authors.initials: Y
authors.lastname: Littner
mesh_terms: D000328:Adult; D001034:Apgar Score; D001724:Birth Weight; D016022:Case-Control Studies; D004900:Erythroblasts / Q000378:metabolism* / Q000648:ultrastructure; D004906:Erythrocyte Count; D005260:Female; D005865:Gestational Age; D006400:Hematocrit; D006801:Humans; D000860:Hypoxia / Q000453:epidemiology / Q000209:etiology*; D007231:Infant, Newborn / Q000097:blood*; D007958:Leukocyte Count; D018655:Lymphocyte Count; D009035:Mothers; D009765:Obesity / Q000503:physiopathology*; D010976:Platelet Count; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012044:Regression Analysis