Tatp-mediated intracellular delivery of pharmaceutical nanocarriers.
CPPs (cell-penetrating peptides), including Tatp (transactivator of transcription peptide), have been successfully used for intracellular delivery of a wide variety of cargoes including various nanoparticulate pharmaceutical carriers such as liposomes, micelles and nanoparticles. Here, we will consider the major results obtained in this area with emphasis on Tatp-mediated delivery of liposomes and various transfection vectors. We will also address the development of 'smart' stimuli-sensitive nanocarriers, where the cell-penetrating function can only be activated when the nanocarrier is inside the biological target, thus minimizing the interaction with non-target cells.
Torchilin
V P
VP
Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA. v.torchilin@neu.edu
D016503:Drug Delivery Systems; D005822:Genetic Vectors / Q000008:administration & dosage*; D008081:Liposomes / Q000008:administration & dosage*; D049329:Nanostructures / Q000008:administration & dosage*; D010455:Peptides / Q000627:therapeutic use*; D015534:Trans-Activators / Q000627:therapeutic use*
D008081:Liposomes; D010455:Peptides; D015534:Trans-Activators