title: [A case of severe hand-foot syndrome caused by capecitabine].
abstract: A 55-year-old woman underwent total mastectomy and axillary lymphnode dissection in 2001. Widespread lymphnode metastasis was found histologically (26/33). Neither PgR nor ER was positive. She underwent an AC regimen and paclitaxel chemotherapy. As CEA began to rise in 2002, she was given paclitaxel and docetaxel chemotherapy sequentially. As CEA rose again in 2004, capecitabine was begun. Painful erythema of the palms and soles of the feet appeared at the end of the second cycle. After admission, severe bone marrow suppression and jaundice were found. The bilateral hands, palms and soles of the feet became bullous and erosive with desquamation. The erosive lesions began to heal with epithelization in the third week. After general conditions had improved, capecitabine was restarted at a reduced dose. This patient had continued taking capecitabine even though she noticed the occurrence of the adverse effect. Patients and doctors must share confidential information when performing chemotherapy at the outpatient clinic.
authors.affiliation: Dept. of Surgery, Nagahama Red Cross Hospital.
authors.forename: Takumi
authors.initials: T
authors.lastname: Shimomatsuya
authors.forename: Yuko
authors.initials: Y
authors.lastname: Mitsudou
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nakamura
authors.forename: Kei
authors.initials: K
authors.lastname: Yonezawa
authors.forename: Susumu
authors.initials: S
authors.lastname: Shiraishi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Fujino
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Maruhashi
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000069287:Capecitabine; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives*; D005533:Foot Dermatoses / Q000139:chemically induced*; D006229:Hand Dermatoses / Q000139:chemically induced*; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D010292:Paresthesia / Q000139:chemically induced*; D011184:Postoperative Period; D013577:Syndrome
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D017239:Paclitaxel; D005472:Fluorouracil