Japanese case of hepatitis B virus genotypes C/D hybrid.
Hepatitis B virus (HBV) is classified into eight genotypes based on complete genome sequence. Each genotype is related to geographic distribution and race. In Japan, most of the genotypes are B and C. In the present study, we report the first Japanese strain of HBV having a recombination between genotypes C and D. A 30-year-old woman was admitted to Kobe Medical Center because of liver dysfunction. She was diagnosed with spontaneous reactivation of chronic hepatitis B. She had no history of blood transfusion and her parents were negative for HBV. The phylogenetic analysis based on the complete genome sequences revealed that this strain was classified into genotype C, whereas the analysis based on Sgene sequence showed that this strain was genotype D. By using a SimPlot program, this strain was confirmed as a recombinant strain between genotypes C and D. Compared with previous recombinant strains in China, the breakpoint was the same and the difference was only 0.8% of the complete genome sequence. It was unclear whether or not this strain was transmitted from China, but the recombinant strains and intergenotypes of HBV have already existed in Japan.
Yano
Yoshihiko
Y
Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, International Center of Medical Research and Treatment (ICMRT), Kobe University Graduate School of Medicine, Kobe, Japan.
Truong
Bui X
BX
Seo
Yasushi
Y
Kato
Hirotaka
H
Miki
Akira
A
Tanaka
Yasuhito
Y
Mizokami
Masashi
M
Kagawa
Ayako
A
Miyazaki
Hiroyuki
H
Kasuga
Masato
M
Azuma
Takeshi
T
Hayashi
Yoshitake
Y