title: BRAF in papillary thyroid carcinoma.
abstract: Novel genetic findings about papillary thyroid carcinoma identify BRAF gene as a subject of great interest. Involvement of BRAF gene in pathogenesis of PTC, diagnostic value and the putative prognostic significance of its T1799A mutation are summarized in this article. Furthermore, a particular attention is focused to the role of pre-operative detection of BRAF mutation in the FNAB specimens of thyroid nodules and to the use of this gene as target for an effective cancer therapy.
authors.affiliation: Istituto Tumori Giovanni Paolo, Bari, Italy.
authors.forename: Salvatore Giovanni
authors.initials: SG
authors.lastname: Lanzilotta
authors.forename: Luciano
authors.initials: L
authors.lastname: Grammatica
authors.forename: Angelo
authors.initials: A
authors.lastname: Paradiso
authors.forename: Gianni
authors.initials: G
authors.lastname: Simone
mesh_terms: D000818:Animals; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004252:DNA Mutational Analysis; D006801:Humans; D009154:Mutation / Q000235:genetics; D011379:Prognosis; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
chemical_list: D048493:Proto-Oncogene Proteins B-raf