Metastasis and stem cell pathways.
Recent studies have described a small population of self-renewing and multipotent cells within tumors termed "cancer stem cells." These cells share many traits with somatic and embryonic stem cells and are thought to be responsible for driving tumor progression in a growing list of neoplastic diseases. Cells within solid tumors encounter hypoxia due to poor vascular function. Both long-standing and emerging data describe hypoxic effects on somatic and embryonic stem cells, and it is likely that hypoxia also has profound effects on cancer stem cells. These effects include the activation of pathways that induce the dedifferentiation of cancer cells, the maintenance of stem cell identity, and increased metastatic potential. Hypoxia may contribute to tumor progression by specifically impacting these pathways in cancer stem cells.
Barnhart
Bryan C
BC
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.
Simon
M Celeste
MC
D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000235:genetics; D015687:Cell Hypoxia / Q000502:physiology*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics; D009362:Neoplasm Metastasis / Q000473:pathology / Q000503:physiopathology*; D013234:Stem Cells / Q000473:pathology / Q000502:physiology*
C497396:ARNT protein, human; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator