Frontal dysfunction during a cognitive task in drug-naive patients with panic disorder as investigated by multi-channel near-infrared spectroscopy imaging.
The present study investigated oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hb]) hemoglobin concentration changes during the performance of a word fluency task in the frontal region of five drug-naive patients with panic disorder with or without agoraphobia and in 33 age-, sex-, and task performance-matched healthy volunteers by using multi-channel near-infrared spectroscopy (NIRS). The left inferior frontal [oxy-Hb] changes during performance of the task in patients with panic disorder were significantly smaller than those of healthy controls. This pilot study suggests the possibility that the left frontal lobe, required for cognitive function, is impaired in patients with panic disorder.
Nishimura
Yukika
Y
Department of Psychiatry, Division of Neuroscience, Mie University, Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, Japan. ynishimu@clin.medic.mie-u.ac.jp
Tanii
Hisashi
H
Fukuda
Masato
M
Kajiki
Naomi
N
Inoue
Ken
K
Kaiya
Hisanobu
H
Nishida
Atsushi
A
Okada
Motohiro
M
Okazaki
Yuji
Y
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities* / Q000098:blood supply / Q000503:physiopathology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D016584:Panic Disorder / Q000473:pathology / Q000503:physiopathology*; D019265:Spectroscopy, Near-Infrared
D006454:Hemoglobins