title: When individual behaviour matters: homogeneous and network models in epidemiology.
abstract: Heterogeneity in host contact patterns profoundly shapes population-level disease dynamics. Many epidemiological models make simplifying assumptions about the patterns of disease-causing interactions among hosts. In particular, homogeneous-mixing models assume that all hosts have identical rates of disease-causing contacts. In recent years, several network-based approaches have been developed to explicitly model heterogeneity in host contact patterns. Here, we use a network perspective to quantify the extent to which real populations depart from the homogeneous-mixing assumption, in terms of both the underlying network structure and the resulting epidemiological dynamics. We find that human contact patterns are indeed more heterogeneous than assumed by homogeneous-mixing models, but are not as variable as some have speculated. We then evaluate a variety of methodologies for incorporating contact heterogeneity, including network-based models and several modifications to the simple SIR compartmental model. We conclude that the homogeneous-mixing compartmental model is appropriate when host populations are nearly homogeneous, and can be modified effectively for a few classes of non-homogeneous networks. In general, however, network models are more intuitive and accurate for predicting disease spread through heterogeneous host populations.
authors.affiliation: Computational and Applied Mathematics, Institute for Computational Engineering and Sciences, University of Texas at Austin, 1 University Station, C0200, Austin, TX 78712, USA.
authors.forename: Shweta
authors.initials: S
authors.lastname: Bansal
authors.forename: Bryan T
authors.initials: BT
authors.lastname: Grenfell
authors.forename: Lauren Ancel
authors.initials: LA
authors.lastname: Meyers
mesh_terms: D018562:Disease Transmission, Infectious; D004812:Epidemiologic Methods; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical