title: Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: technical considerations.
abstract: Technical variants of mania and depression models that were based on dominant-submissive relationships (DSR) have been analyzed and compared in the present paper. In these paradigms, one animal of a pair developed the behavioral trait of dominance while the other submissiveness in a food competition test after repeated interactions in a specially designed apparatus. Data collection methods and timelines have been compared in variants of the DSR-based models. In addition, different selection criteria to assign dominant or submissive status to animals and two different scoring systems were evaluated. The importance of the selection criteria for DSR stability has been emphasized. Our data showed that (1) only animals selected with the strict criteria form clear dominant and submissive relationships that hold throughout the study period, (2) submissive animals were influenced by fluoxetine and dominant animals were influenced by sodium valproate similarly in pairs scored by human observer and by a video-tracking system. These studies indicate that the model variant using stringent selection criteria and automatic scoring was the most reliable for use in depression-related studies.
authors.affiliation: Drug Discovery, CNS Research, East Coast Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Spring House, PA 19477, USA. Emalatyn@PRDUS.jnj.com
authors.forename: Ewa
authors.initials: E
authors.lastname: Malatynska
authors.forename: Albert
authors.initials: A
authors.lastname: Pinhasov
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Crooke
authors.forename: Virginia L
authors.initials: VL
authors.lastname: Smith-Swintosky
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Brenneman
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D018692:Antimanic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D003627:Data Interpretation, Statistical; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D004195:Disease Models, Animal; D004291:Dominance-Subordination; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005247:Feeding Behavior / Q000502:physiology; D005473:Fluoxetine / Q000494:pharmacology; D009483:Neuropsychological Tests / Q000592:standards; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D012919:Social Behavior; D014635:Valproic Acid / Q000494:pharmacology; D014743:Videotape Recording / Q000379:methods
chemical_list: D000928:Antidepressive Agents; D018692:Antimanic Agents; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors; D014635:Valproic Acid