title: No evidence for myocardial iron overload in multitransfused patients with myelodysplastic syndrome using cardiac magnetic resonance T2 technique.
abstract: The method of cardiovascular T2 magnetic resonance imaging (MRI) allows in vivo estimation of iron in the heart and liver and was used to measure the degree of iron overload in 10 transfused MDS patients (average 90 blood units) and in 3 patients with congenital hemolytic anemia. In all MDS patients iron overload was found in the liver but not in the heart. Patients with congenital anemias had iron in both organs despite iron chelation. It is possible that in MDS more time and more transfusions are required to induce iron accumulation in the myocardium. Therefore, cardiac MRI may serve as a diagnostic tool to assess if and when iron chelation is indicated.
authors.affiliation: Department of Diagnostic Imaging, Chaim Sheba Medical Center, Tel Hashomer, Israel. eli.konen@sheba.health.gov.il
authors.forename: Eli
authors.initials: E
authors.lastname: Konen
authors.forename: Husam
authors.initials: H
authors.lastname: Ghoti
authors.forename: Orly
authors.initials: O
authors.lastname: Goitein
authors.forename: Asher
authors.initials: A
authors.lastname: Winder
authors.forename: Tammi
authors.initials: T
authors.lastname: Kushnir
authors.forename: Yael
authors.initials: Y
authors.lastname: Eshet
authors.forename: Eliezer
authors.initials: E
authors.lastname: Rachmilewitz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis* / Q000378:metabolism; D019190:Iron Overload / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000628:therapy; D009206:Myocardium / Q000737:chemistry* / Q000378:metabolism; D065227:Transfusion Reaction
chemical_list: D007501:Iron