Outcome after surgical treatment of gastrointestinal stromal tumors.
OBJECTIVE
The objectives were to determine among gastrointestinal mesenchymal tumors treated surgically in our unit which were gastrointestinal stromal tumors (GISTs) and to describe their characteristic features and prognostic factors.


METHODS
A second histological and immunohistochemical reading was performed for 56 gastrointestinal mesenchymal tumors, treated surgically in the Reims University Hospital between 1990 and 2005 in order to determine which ones were GISTs. A statistical descriptive and analytical analysis of the demographic, pathological, therapeutic and prognostic factors was performed.


RESULTS
Eighty-seven percent of the tumors were GISTs. The 5-year specific survival rate was 66.8%. The factors of good prognosis were small tumor size, low mitotic count, complete primary tumor resection without tumor effraction, age less than 60 years, absence of mucosal necrosis, ulceration, and invasion. Type of surgical resection had no impact in terms of survival.


CONCLUSIONS
GISTs are the most common mesenchymal tumors of the digestive tract. Even thought treatment with imatinib is currently available, surgery (preferably total resection without effraction) is the mainstay treatment for GISTs.
Weber
Anne-Géraldine
AG
Service de Chirurgie Viscérale, Digestive et Endocrinienne, CHU de Reims, avenue du Général Koenig, 51092 Reims Cedex. AGWEBER@chu-reims.fr
Jovenin
Nicolas
N
Lubrano
Denis
D
Journu
Jérome
J
Yaziji
Nallah
N
Bouche
Olivier
O
Diebold
Marie-Danièle
MD
Delattre
Jean-François
JF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome