Granulomatous infiltration with replacement of liver parenchyma: first case report.
A 76-year-old man presented with fever, weight loss and abnormal liver function tests. Imaging demonstrated a diffusely abnormal liver, and a liver biopsy revealed a fibrosing granulomatous process infiltrating and replacing liver parenchyma. There was no clinical, radiological or laboratory evidence of autoimmune liver disease, sarcoidosis, lymphoma or tuberculosis. Treatment with steroids resulted in a remarkable resolution of the clinical symptoms and radiology. This is the first case of granulomatous infiltration of the liver replacing normal hepatic parenchyma.
Millson
Charles E
CE
Liver Unit, Department of Radiology, St James's University Hospital, Leeds, UK. charles.millson@leedsth.nhs.uk
Guthrie
J A
JA
Sahay
P
P
Wyatt
J I
JI
D000368:Aged; D005938:Glucocorticoids / Q000627:therapeutic use; D006099:Granuloma / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use
D005938:Glucocorticoids; D011239:Prednisolone