ZAP70 in chronic lymphocytic leukaemia.
The protein tyrosine kinase zeta-chain associated protein kinase (ZAP70), normally expressed in T cells and a subset of B cells, is solely expressed in poor prognosis chronic lymphocytic leukaemia and implicated in enhanced B cell receptor signalling. As a result, the expression of this protein provides an ideal prognostic marker for the disease. A previous study has shown differential CpG methylation of a 5' region of ZAP70 in leukaemic lymphoid cells, although no further epigenetic studies have been reported. Further investigation into the expression of ZAP70 may therefore provide targets for therapies.
Amin
Shilu
S
Cell Signalling, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom. shilu.amin@ncl.ac.uk
Parker
Anton
A
Mann
Jelena
J
D000818:Animals; D004789:Enzyme Activation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
D051746:ZAP-70 Protein-Tyrosine Kinase