title: Structural insights into early events in the conjugation of ubiquitin and ubiquitin-like proteins.
abstract: NMR studies of the SUMO-activating enzyme in complex with Ubc9 (Wang et al., 2007, this issue of Molecular Cell) complement a recent crystal structure of Ubc12 bound to the NEDD8-activating enzyme ternary complex (Huang et al., 2007), elucidating details of the first steps in the conjugation of ubiquitin and ubiquitin-like proteins.
authors.affiliation: Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine, 1901 Perdido Street, New Orleans, LA 70112, USA. Electronic address: ahaas@lsuhsc.edu.
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Haas
mesh_terms: D006801:Humans; D015394:Molecular Structure; D046912:Multiprotein Complexes; D019906:Nuclear Magnetic Resonance, Biomolecular; D025801:Ubiquitin / Q000737:chemistry* / Q000378:metabolism*; D014452:Ubiquitins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D025801:Ubiquitin; D014452:Ubiquitins