Prediction of B cell and T cell epitopes of DBLalpha domain in Plasmodium falciparum malaria vaccine candidate var gene.
P. falciparum encodes PfEMP-1 which is important in pathogenicity and virulence. We have analyzed the structure of the Duffy binding like (DBLalpha) domain of var genes and predicted the antigenic sites and T and B cell epitopes which present a highly variable picture with major implications in immune interactions and vaccine design.
Ozarkar
Aarti D
AD
Molecular Biology Research Laboratory, Department of Zoology and Institute of Bioinformatics and Biotechnology, University of Pune, Pune-411007, India.
Prakash
D
D
Deobagkar
Dileep N
DN
Deobagkar
Deepti D
DD
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry / Q000276:immunology; D018985:Epitopes, B-Lymphocyte / Q000737:chemistry / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry / Q000276:immunology*; D007194:India; D017780:Malaria Vaccines; D016778:Malaria, Falciparum / Q000276:immunology / Q000469:parasitology; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D021122:Protein Subunits; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000276:immunology; D016415:Sequence Alignment
D000953:Antigens, Protozoan; C066001:Duffy antigen binding protein, Plasmodium; D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D017780:Malaria Vaccines; D021122:Protein Subunits; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface; C085731:erythrocyte membrane protein 1, Plasmodium falciparum