title: Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows.
abstract: Genotyping of bovine leucocyte antigen DRB3.2 (BoLA-DRB3.2) in a total of 523 Norwegian Red (NR) cows from two groups selected for high protein yield and low clinical mastitis, respectively, identified 27 previously reported BoLA-DRB3.2 alleles across the groups. Significant differences in BoLA-DRB3.2 allele frequencies were found between the selection groups. Alleles *13, *18, *22 and *27 had a significantly higher frequency in cows selected for low clinical mastitis, while alleles *3, *9, *11 and *26 had a higher frequency in cows selected for high protein yield. Associations between BoLA-DRB3.2 alleles and clinical mastitis were analysed based on mastitis data from 741,072 first-lactation NR cows, of which 452 were genotyped. Alleles *22 and *26 were found to be associated with increased clinical mastitis, while alleles *7, *11, *18 and *24 had a favourable effect on mastitis resistance. Contradictory results from different studies investigating associations between BoLA-DRB3.2 alleles and mastitis indicate that future studies should focus on associations of mastitis with BoLA haplotypes rather than with single BoLA genes.
authors.affiliation: Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway. siri.kulberg@umb.no
authors.forename: S
authors.initials: S
authors.lastname: Kulberg
authors.forename: B
authors.initials: B
authors.lastname: Heringstad
authors.forename: O A
authors.initials: OA
authors.lastname: Guttersrud
authors.forename: I
authors.initials: I
authors.lastname: Olsaker
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D008414:Mastitis, Bovine / Q000453:epidemiology / Q000235:genetics; D015233:Models, Statistical; D009664:Norway; D013045:Species Specificity
chemical_list: C423282:BoLA-DRB3 antigen; D000949:Histocompatibility Antigens Class II