Significance of lymphatic invasion and proliferation on regional lymph node metastasis in renal cell carcinoma.
We studied the associations of lymphatic invasion and lymphatic vessel density around tumors with lymph node (LN) status in renal cell carcinoma (RCC) by immunohistochemical analysis using D2-40 antibody as a lymphatic marker. Surgically removed specimens from 76 cases with RCC, including 16 cases with LN metastasis, were used. Lymphatic vessel density around the tumor increased compared with normal kidneys but was not significant by LN status. Tumor size, tumor cell types, patterns of tumor growth, nuclear grade of tumor cells, venous invasion, lymphatic invasion, and primary tumor stage were predictive factors for LN metastasis. Based on multivariate regression analysis, only lymphatic invasion was an independent risk factor for LN metastasis. The immunohistochemical detection of lymphatics was useful for identifying the lymphatic invasion of RCC, and the presence of lymphatic invasion around RCC was an independent predictive factor for LN metastasis.
Ishikawa
Yukio
Y
Department of Pathology, Toho University School of Medicine, Tokyo, Japan.
Aida
Shinsuke
S
Tamai
Seiichi
S
Akasaka
Yoshikiyo
Y
Kiguchi
Hideko
H
Akishima-Fukasawa
Yuri
Y
Hayakawa
Masamichi
M
Soh
Shigehiro
S
Ito
Kinji
K
Kimura-Matsumoto
Masayo
M
Ishiguro
Shigeki
S
Nishimura
Chiaki
C
Kamata
Itaru
I
Shimokawa
Reiko
R
Ishii
Toshiharu
T
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D058846:Antibodies, Monoclonal, Murine-Derived; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D042582:Vascular Endothelial Growth Factor C / Q000032:analysis
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D042582:Vascular Endothelial Growth Factor C; C500987:monoclonal antibody D2-40