Incidental MRI detection of BRCA1-related solitary peritoneal carcinoma during breast screening--A case report.
BACKGROUND
The reported cumulative risk of developing primary peritoneal carcinoma (PPC) one to 20 years after prophylactic bilateral oophorectomy is 3.5% to 4.3%. Virtually all reported cases have been stage III or IV.


METHODS
During MRI screening of the breasts, an incidental mass on the surface of the liver was identified in a 56-year-old BRCA1 mutation carrier who had undergone prophylactic bilateral salpingo-oophorectomy several years previously with no evidence of malignancy. After four cycles of chemotherapy a localized, grade 3 serous papillary adenocarcinoma was resected followed by further chemotherapy and radiation. She remains disease-free 3 years post-treatment.


CONCLUSIONS
The literature on PPC after prophylactic oophorectomy is reviewed. To the best of our knowledge, this is the first description of an apparently localized case of BRCA related PPC outside the pelvis.
Hill
Kimberley A
KA
Division of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, T2 053, Toronto, Ontario, Canada M4N 3M5. kimberley.hill@sunnybrook.ca
Rosen
Barry
B
Shaw
Patricia
P
Causer
Petrina A
PA
Warner
Ellen
E
D000231:Adenocarcinoma, Papillary / Q000175:diagnosis*; D001943:Breast Neoplasms / Q000235:genetics; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D033162:Incidental Findings; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010052:Ovariectomy; D010534:Peritoneal Neoplasms / Q000175:diagnosis*