Endothelin-1-induced cerebral ischemia: effects of ketanserin and MK-801 on limb placing in rats.
The long-term effects of the 5-HT(2A) receptor antagonist ketanserin on deficits in sensorimotor integration (limb placing tests) following transient focal cerebral ischemia in rats were compared to the effects of the NMDA antagonist MK-801. Middle cerebral artery occlusion was induced in conscious rats by microinjection of endothelin-1 in the vicinity of the artery (EMCAO model). The EMCAO/vehicle rats exhibited impaired tactile and proprioceptive limb placing. In contrast to ketanserin, MK-801 exerted severe early behavioral disturbances, but both drugs significantly improved the neurological scores much earlier than the spontaneous recovery of function occurred. The present results suggest that pharmacotherapy by means of ketanserin lacking the severe side effects of the NMDA antagonists can be used to enhance functional recovery after stroke.
Moyanova
S
S
Bulgarian Academy of Sciences, Department of Neurobiology of Adaptation, Institute of Neurobiology, Sofia, Bulgaria. s06moy@yahoo.com
Kortenska
L
L
Mitreva
R
R
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D002545:Brain Ischemia / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000627:therapeutic use*; D019332:Endothelin-1; D005121:Extremities / Q000503:physiopathology*; D007650:Ketanserin / Q000627:therapeutic use*; D008297:Male; D009460:Neurologic Examination; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index
D019332:Endothelin-1; D018696:Neuroprotective Agents; D010975:Platelet Aggregation Inhibitors; D016291:Dizocilpine Maleate; D007650:Ketanserin