Induction of cytochrome P4502B: role of regulatory elements and nuclear receptors.
Cytochrome P450 of the 2B subfamily is easily induced by many xenobiotics. In spite of intensive investigations, the molecular mechanisms of regulation of the CYP2B genes are not clear. The nuclear receptor CAR is shown to play a crucial role in the activation of CYP2B genes by xenobiotics, but many problems of CAR activation in different animal species and humans remain unsolved. This review focuses on signaling pathways involved in the control of CYP2B gene expression in mammals.
Pustylnyak
V O
VO
Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk 630117, Russia. pustylnyak@ngs.ru
Gulyaeva
L F
LF
Lyakhovich
V V
VV
D000818:Animals; D001483:Base Sequence; D019362:Cytochrome P-450 CYP2B1 / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D050436:Regulatory Elements, Transcriptional / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D015533:Transcriptional Activation; D015262:Xenobiotics / Q000494:pharmacology
D018160:Receptors, Cytoplasmic and Nuclear; D015262:Xenobiotics; D019362:Cytochrome P-450 CYP2B1; D010634:Phenobarbital