title: Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J.
abstract: A new Ginkgo biloba extract P8A (TTL), 70% enriched with terpene trilactones, prevents A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. This neuroprotective effect is attributed in large part to ginkgolide J that completely replicates the effect of the extract. Ginkgolide J is also capable of inhibiting cell death of rodent hippocampal neurons caused by A beta(1-42). This beneficial and multi-faceted mode of action of the ginkgolide makes it a new and promising lead in designing therapies against Alzheimer's disease.
authors.affiliation: Department of Pathology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
authors.forename: Ottavio
authors.initials: O
authors.lastname: Vitolo
authors.forename: Bing
authors.initials: B
authors.lastname: Gong
authors.forename: Zixuan
authors.initials: Z
authors.lastname: Cao
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishii
authors.forename: Stanislav
authors.initials: S
authors.lastname: Jaracz
authors.forename: Koji
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Ottavio
authors.initials: O
authors.lastname: Arancio
authors.forename: Sergei V
authors.initials: SV
authors.lastname: Dzyuba
authors.forename: Roger
authors.initials: R
authors.lastname: Lefort
authors.forename: Michael
authors.initials: M
authors.lastname: Shelanski
mesh_terms: D016229:Amyloid beta-Peptides / Q000008:administration & dosage*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D046934:Ginkgolides / Q000008:administration & dosage*; D007783:Lactones / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D018696:Neuroprotective Agents / Q000008:administration & dosage; D010446:Peptide Fragments / Q000008:administration & dosage*; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
chemical_list: D016229:Amyloid beta-Peptides; D046934:Ginkgolides; D007783:Lactones; D018696:Neuroprotective Agents; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); C075228:ginkgolide J