title: [Cerebral inhibitory functioning in patients with attention deficit/hyperactivity disorder. I. Analysis of non-target-P300 component in a visual oddball paradigm].
abstract: The present study was organized to evaluate the cerebral inhibitory function in children with developmental disorders such as attention deficit/hyperactivity disorder (AD/HD) and pervasive developmental disorder (PDD). Target and non-target-P300 event related potential (ERP) in response to stimuli of a visual oddball paradigm was analyzed. Ten children with AD/HD, 10 children with PDD and 10 healthy children were included in the study participants. Target-P300 component was observed in all subjects, which showed predominant amplitudes in Pz electrode. No significant differences were observed in amplitude and latency of target-P300 among three groups. In healthy children, Non-target-P300 component was observed mainly in Cz and Pz electrodes, while children with AD/HD had significantly reduced amplitudes of the component at Cz and children with PDD showed shorter latency at Oz. These results suggest that Non-target-P300 component in visual oddball paradigm possibly reflects the brain function associated with inhibitory processing and there is a relationship between the non-target-P300 potential abnormality and the AD/HD behavior.
authors.affiliation: Department of Developmental Disorder, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Inoue
authors.forename: Masumi
authors.initials: M
authors.lastname: Inagaki
authors.forename: Atsuko
authors.initials: A
authors.lastname: Gunji
authors.forename: Naomi
authors.initials: N
authors.lastname: Kokubo
authors.forename: Makiko
authors.initials: M
authors.lastname: Kaga
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D001921:Brain / Q000502:physiology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000502:physiology