Global virulence regulation networks in phytopathogenic bacteria.
Phytopathogens coordinate multifaceted life histories and deploy stratified virulence determinants via complex, global regulation networks. We dissect the global regulation of four distantly related model phytopathogens to evaluate large-scale events and mechanisms that determine successful pathogenesis. Overarching themes include dependence on centralized cell-to-cell communication systems, pervasive two-component signal-transduction systems, post-transcriptional regulation systems, AraC-like regulators and sigma factors. Although these common regulatory systems control virulence, each functions in different capacities, and to differing ends, in the diverse species. Hence, the virulence regulation network of each species determines its survival and success in various life histories and niches.
Mole
Beth M
BM
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Baltrus
David A
DA
Dangl
Jeffery L
JL
Grant
Sarah R
SR
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D018551:Solanum lycopersicum / Q000382:microbiology; D044043:Pectobacterium / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D010935:Plant Diseases / Q000382:microbiology*; D044224:Pseudomonas syringae / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D043368:Ralstonia solanacearum / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D015398:Signal Transduction; D011198:Solanum tuberosum / Q000382:microbiology; D014774:Virulence; D016959:Xanthomonas campestris / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*
D001426:Bacterial Proteins