Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.
Soellner
Matthew B
MB
Department of Chemistry, University of California, Berkeley, California 94720, USA.
Rawls
Katherine A
KA
Grundner
Christoph
C
Alber
Tom
T
Ellman
Jonathan A
JA
D001713:Biphenyl Compounds / Q000737:chemistry; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology*; D010710:Phosphates / Q000737:chemistry / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D013053:Spectrophotometry; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D010710:Phosphates; D010744:Phosphoric Monoester Hydrolases; D011505:Protein-Tyrosine Kinases; C010574:biphenyl