Recent developments in naturally derived antimalarials: cryptolepine analogues.
Increasing resistance of Plasmodium falciparum to commonly used antimalarial drugs has made the need for new agents increasingly urgent. In this paper, the potential of cryptolepine, an alkaloid from the West African shrub Cryptolepis sanguinolenta, as a lead towards new antimalarial agents is discussed. Several cryptolepine analogues have been synthesized that have promising in-vitro and in-vivo antimalarial activity. Studies on the antimalarial modes of action of these analogues indicate that they may have different or additional modes of action to the parent compound. Elucidation of the mode of action may facilitate the development of more potent antimalarial cryptolepine analogues.
Wright
Colin W
CW
The School of Pharmacy, University of Bradford, West Yorkshire, BD7 1DP, UK. c.w.wright@bradford.ac.uk
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D002738:Chloroquine / Q000494:pharmacology; D031106:Cryptolepis; D004351:Drug Resistance; D006801:Humans; D026121:Indole Alkaloids / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use
D000962:Antimalarials; D026121:Indole Alkaloids; D011804:Quinolines; C024015:cryptolepine; D002738:Chloroquine