Total oxidant/antioxidant status in jaundiced newborns before and after phototherapy.
OBJECTIVE
To assess the effect of phototherapy on serum oxidant and antioxidant status in hyperbilirubinemic full-term newborns.


METHODS
Thirty-four full-term infants from 3 to 10 days of age exposed to phototherapy were studied. The serum antioxidant status was assessed by measuring the total antioxidant capacity (TAC) and individual antioxidant components: vitamin C, uric acid, albumin, thiol contents and total bilirubin. The oxidant status was assessed by determining the total oxidant status (TOS), oxidative stress index (OSI) and individual oxidant components: malondialdehyde (MDA), and lipid hydroperoxide levels.


RESULTS
Vitamin C, uric acid, total bilirubin and MDA concentration were significantly lower, whereas serum TOS, lipid hydroperoxide and OSI levels were significantly higher after phototherapy (p < 0.05). There were significant positive correlations between serum total bilirubin and MDA (r = 0.434, p = 0.001).


CONCLUSIONS
Although the MDA level was reduced after phototherapy, phototherapy has a negative impact on numerous parts of the oxidant/antioxidant defense system in jaundiced full-term newborns, exposing them to potential oxidative stress.
Aycicek
Ali
A
Children's Hospital at Sanliurfa, Sanliurfa, Turkey. ayciceka@hotmail.com
Erel
Ozcan
O
D001205:Ascorbic Acid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood* / Q000628:therapy; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D010789:Phototherapy / Q000009:adverse effects*; D014527:Uric Acid / Q000097:blood
D015415:Biomarkers; D008054:Lipid Peroxides; D014527:Uric Acid; D008315:Malondialdehyde; D001205:Ascorbic Acid