title: Pneumocystis pneumonia in a patient with type 2 diabetes mellitus.
abstract: A 76-year-old man, who was in the hospital for the treatment of type 2 diabetes mellitus and was receiving gonadotropin-releasing hormone (GnRH) agonist treatment for prostate cancer, developed fever and hypoxemia. Imaging revealed diffuse interstitial shadows, and PCR of the bronchoalveolar lavage fluid was positive for Pneumocystis jirovecii. The patient's absolute CD4-positive lymphocyte count dropped to 145/microl, but the HIV antibody was negative. After trimethoprim-sulfamethoxazole (TMP/SXT) treatment, the absolute CD4 positive lymphocyte count returned to normal. This patient with type 2 diabetes mellitus developed Pneumocystis pneumonia and developed a transient decrease in CD4-positive lymphocytes.
authors.affiliation: Department of Respiratory Medicine, Toho University Ohashi Medical Center, Tokyo.
authors.forename: Ken
authors.initials: K
authors.lastname: Sanno
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hatanaka
authors.forename: Toru
authors.initials: T
authors.lastname: Yamagishi
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kamemura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirano
authors.forename: Norio
authors.initials: N
authors.lastname: Kodaka
authors.forename: Atsuo
authors.initials: A
authors.lastname: Miura
authors.forename: Asako
authors.initials: A
authors.lastname: Kitahara
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sawata
authors.forename: Kimio
authors.initials: K
authors.lastname: Hosaka
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakazawa
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D018791:CD4 Lymphocyte Count; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D006801:Humans; D008297:Male; D045363:Pneumocystis carinii / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination