title: [Prevalence of supraesophageal manifestations in patients with gastroesophageal erosive and non-erosive reflux disease].
abstract: BACKGROUND
  Respiratory, ear-nose and throat complaints, chest pain and dysphagia can be a part of clinical manifestations of gastroesophageal reflux disease. The first two are named supraesophageal manifestations of gastroesophageal reflux disease. Controversy about the prevalence of these clinical manifestations in patients with non-erosive and erosive gastroesophageal reflux disease exists.
  
  
  OBJECTIVE
  Evaluate the prevalence of supraesophageal manifestations in patients with erosive and non-erosive gastroesophageal reflux disease.
  
  
  METHODS
  Files from patients submitted to upper endoscopy, esophageal manometry and pH monitoring for the investigation of gastroesophageal reflux disease (heartburn as the chief complaint) were reviewed and respiratory and ear, nose and throat symptoms were recorded. Patients with erosive disease (grades I to III according to Savary-Miller classification) and with non-erosive disease (normal endoscopy with abnormal pH monitoring were selected. Statistical analysis included the chi-square test.
  
  
  RESULTS
  Two hundred and eighty patients fulfilled the inclusion criteria being 162 with erosive disease (70% with grade I esophagitis) and 118 with non-erosive disease. Overall, 88 patients had ear, nose and throat symptoms (31%), the more frequent were hoarseness and clearing and 42, respiratory manifestations (15%), being cough the more prevalent. In the ear, nose and throat symptoms group, 45 were erosive disease (28%) and 43 non-erosive disease (36.4%). As for the respiratory symptom group, 21 patients (13%) were erosive disease and 21 (18%) were non-erosive disease.
  
  
  CONCLUSIONS
  There was no difference in the prevalence of supraesophageal manifestations between patients with gastroesophageal erosive and non-erosive reflux disease.
authors.affiliation: Universidade Gama Filho.
authors.forename: Gustavo Cálcena
authors.initials: GC
authors.lastname: Aguero
authors.forename: Eponina M O
authors.initials: EM
authors.lastname: Lemme
authors.forename: Angela
authors.initials: A
authors.lastname: Alvariz
authors.forename: Beatriz Biccas
authors.initials: BB
authors.lastname: Carvalho
authors.forename: Rosana B
authors.initials: RB
authors.lastname: Schechter
authors.forename: Luiz
authors.initials: L
authors.lastname: Abrahão
mesh_terms: D004945:Esophagoscopy; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010038:Otorhinolaryngologic Diseases / Q000175:diagnosis / Q000209:etiology*; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000209:etiology*; D012720:Severity of Illness Index