[Electroencephalographic changes in headaches under the influence of pharmaceuticals].
Headache can be manifested as primary disorder or it is a secondary symptom of some other illnes. Electroencephalography (EEG) is electrodiagnostic method which registers electric activity of brain cells and by this method therapeutic effect of single medicaments can be followed by comparing of EEG before and after medication. The aim of work was to test if there are changes in EEG in headaches under the influence of naproxen and sumatriptan in the acute attack of headache and during the prevention of often attacks of pain.


RESULTS
The retrospectiveprospective study was conducted on 92 patients, average age of 42.9 with regular CT of cranium, craniogram and fundus. They were divided in two groups based on drugs they were taking for the prevention or treatment of acute attack of pain. Group A 44 patients preventively took naproxen in the daily dose of 550 mg and in acute attack of pain sumatriptan and group B 48 patients in the acute attack of pain took sumatripanin one dose of 50 mg. Two EEG were recorded before and after medication and concentration of certain waves in EEG was followed. Statistics proved that there is no statistic difference in the EEG before and after medication. Hi square test (Hi Sq. = 1.087) does not show statistically important difference within the number of patients divided in groups, significance is on leve p = 0.297. T-test does not show existence of statistically important difference between concentration of Alpha, beta, teta and delta waves in starting EEG and in EEG at the end of testing after taking on Naproxen 550 mg daily for one month for group A and a pill of Sumatriptan in the acute attack for group B.


CONCLUSIONS
It means that naproxen and sumatriptan at patients with headaches do not cause changes in EEG, nor percent concentration of single waves in starting and control EEG and statistically significant reduce pain at tested patients with vascular headaches.
Musić
Miralem
M
Institut za patolosku fiziologiju, Medicinski fakultet Univerziteta u Sarajevu. miralem13@gmail.com
Masić
Izet
I
D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000627:therapeutic use; D018170:Sumatriptan / Q000627:therapeutic use; D014653:Vascular Headaches / Q000188:drug therapy / Q000503:physiopathology*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014662:Vasoconstrictor Agents; D009288:Naproxen; D018170:Sumatriptan