CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.
The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain-containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes with BRCA1 and is required for the formation of BRCA1 foci in response to ionizing radiation. Moreover, like BRCA1, CCDC98 has a role in radiation sensitivity and damage-induced G2/M checkpoint control. Together, these results suggest that CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.
Kim
Hongtae
H
Department of Therapeutic Radiology, Yale University School of Medicine, P.O. Box 208040, New Haven, Connecticut 06520, USA.
Huang
Jun
J
Chen
Junjie
J
D020816:Amino Acid Motifs; D019313:BRCA1 Protein / Q000378:metabolism*; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology; D002460:Cell Line; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D025941:Protein Interaction Mapping; D017434:Protein Structure, Tertiary; D015398:Signal Transduction
C520310:ABRAXAS1 protein, human; D019313:BRCA1 Protein; D002352:Carrier Proteins