title: Synthesis of the entire carbon framework of the kedarcidin chromophore aglycon.
abstract: In advanced studies directed toward the total synthesis of the kedarcidin chromophore, we have successfully achieved the late-stage installation of the nine-membered diyne ring in the presence of the highly functionalised ansamacrocyclic bridge.
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshimura
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Lear
authors.forename: Isao
authors.initials: I
authors.lastname: Ohashi
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Koyama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hirama
mesh_terms: D002244:Carbon / Q000737:chemistry*; D003516:Cycloparaffins / Q000138:chemical synthesis* / Q000737:chemistry; D053281:Enediynes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003516:Cycloparaffins; D053281:Enediynes; D009281:Naphthalenes; C080542:kedarcidin chromophore; D002244:Carbon