[Gastro-entero anastomosis with flexible endoscope with the help of rare-earth magnets on biosynthetic model made of the gastrointestinal tract of slaughtered pigs].
Gastro-entero anastomosis with flexible endoscope with the help of rare-earth magnets on biosynthetic model made of the gastrointestinal tract of slaughtered pigs


BACKGROUND
Numerous malignant diseases may cause gastric outlet obstruction. The surgical gastrointestinal bypass, besides the fact that it requires narcosis, is also associated with high risks for patients with poor general condition. Endoscopic insertion of self-expandable metal stent is less invasive, but often causes complications. In the last years some studies examined a new minimal invasive technique, in which magnets are used to create gastroenteric anastomosis.


METHODS
A biosynthetic model was developed from combined synthetic materials with biogenic specimens taken from slaughtered domestic pigs. The procedure was performed with endoscopic and fluoroscopic guidance. To increase X-ray contrast differences the model was put into physiological saline solution. Two rare-earth magnets (Br: 2500 Gauss, D: 10 mm) with central hole were inserted with the help of a guiding wire and duodenal probe. The first magnet was placed in the first jejunal loop; the second one was placed in the stomach. The gastric magnet was maneuvered using the endoscope. When the magnets reached the right position, the guiding wires were removed to let the magnets stick together. The pressure between the magnets will result in a sterile inflammation on the living tissue which develops adhesion between the bowels, and 7-10 days later anastomosis will develop as a result of the necrosis.


RESULTS
The biosynthetic model could be used for training endoscopy without sacrificing animals. In the end of the procedure the magnets stuck together across gastric and jejunal walls in all ten cases successfully. By practice the period necessary for the procedure could be decreased from 40 to 20 minutes.


CONCLUSIONS
The technique could be made with standard upper endoscope and instruments, and after practice on living animals it could potentially be a useful solution for complaints of gastric outlet obstruction.
Lukovich
Péter
P
Altalános Orvostudományi Kar, I. sz. Sebeszeti Klinika.
Jónás
Attila
A
Bata
Pál
P
Tari
Krisztina
K
Váradi
Gábor
G
Kádár
Balázs
B
Mehdi
Sadat Akhavi
SA
Kupcsulik
Péter
P
D000714:Anastomosis, Surgical; D000818:Animals; D004195:Disease Models, Animal; D016099:Endoscopy, Gastrointestinal; D004867:Equipment Design; D005471:Fluoroscopy; D017219:Gastric Outlet Obstruction / Q000209:etiology / Q000601:surgery*; D007422:Intestines / Q000601:surgery*; D008280:Magnetics; D013270:Stomach / Q000601:surgery*; D013552:Swine