Ph3As-catalyzed wittig-type olefination of aldehydes with diazoacetate in the presence of Na2S2O4.
In the presence of sodium hydrosulfite and a catalytic amount of AsPh3 and Fe(TCP)Cl, aldehydes react with ethyl diazoacetate to give the corresponding alpha,beta-unsaturated esters in high yields with excellent stereoselectivities (E/Z > 50/1).
Cao
Peng
P
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
Li
Chuan-Ying
CY
Kang
Yan-Biao
YB
Xie
Zuowei
Z
Sun
Xiu-Li
XL
Tang
Yong
Y