title: [Lactogenic effects of hyperinsulinemic-euglycaemic clamp in goats].
abstract: In the experiment performed on lactating goats, insulin was infused into the jugular vein over during 2 days every day at the rate 2 mg/kg/hour during 6 hour synchronously with glucose at variable rate to maintain euglycaemia; the transport activity (T, in clearance units) was estimated using the equation: T = Q x E/ (1-E), where Q is plasma flow and E is extraction efficiency. At the end of infusion of the 1st and 2nd days, insulin level in the blood was increased by 63 and 82%, mammary plasma flow by 38 and 78%, milk secretion rate by 23.7 and 31.3 %, milk protein yield by 21.4 and 40%, transport activity of glucose by 63 %, and amino acids by 18% (all p < 0.05) compared to control, respectively. The data obtained suggest that productive effect resulted from elevated metabolic activity of secretory cells and increased mammary blood flow.
authors.forename: Z N
authors.initials: ZN
authors.lastname: Makar
authors.forename: G G
authors.initials: GG
authors.lastname: Cherepanov
authors.forename: M I
authors.initials: MI
authors.lastname: Sapunov
authors.forename: R I
authors.initials: RI
authors.lastname: Korneeva
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D015309:Glucose Clamp Technique; D006041:Goats / Q000502:physiology*; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood; D007774:Lactation / Q000187:drug effects*; D008321:Mammary Glands, Animal / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose