title: Growth hormone producing prolactinoma in juvenile cystinosis: a simple coincidence?
abstract: Juvenile cystinosis was diagnosed in a patient who presented with severe headache attacks and photophobia. Treatment with oral cysteamine and topical cysteamine eye drops was started. One-and-a-half years later, he developed unilateral gynecomastia and elevated prolactin and growth hormone levels. A pituitary macroprolactinoma was discovered and successfully treated with the dopamine agonist cabergoline. Increased serum growth hormone levels were attributed to enhanced growth hormone production by the prolactinoma and somatostatin inhibition by cysteamine. Although the occurrence of prolactinoma in this patient could be a simple coincidence, it might also be a rare yet unrecognised complication of cystinosis.
authors.affiliation: Department of Pediatric Nephrology, University Medical Centre St Radboud, Nijmegen, The Netherlands.
authors.forename: Martine T P
authors.initials: MT
authors.lastname: Besouw
authors.forename: Elena N
authors.initials: EN
authors.lastname: Levtchenko
authors.forename: Michèl A A P
authors.initials: MA
authors.lastname: Willemsen
authors.forename: Kees
authors.initials: K
authors.lastname: Noordam
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D001827:Body Height / Q000187:drug effects; D000077465:Cabergoline; D002648:Child; D003543:Cysteamine / Q000627:therapeutic use; D003554:Cystinosis / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D018491:Dopamine Agonists / Q000627:therapeutic use; D004873:Ergolines / Q000627:therapeutic use; D006261:Headache / Q000209:etiology; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D015175:Prolactinoma / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D018491:Dopamine Agonists; D004873:Ergolines; D009883:Ophthalmic Solutions; D011837:Radiation-Protective Agents; D019382:Human Growth Hormone; D003543:Cysteamine; D000077465:Cabergoline