The effects of vigabatrin on spike and wave discharges in WAG/Rij rats.
The effects of vigabatrin, which increases GABA concentrations by inhibiting GABA transaminase, on spike and wave discharges (SWDs) in the electroencephalogram of WAG/Rij rats were studied. Vigabatrin increased the incidence and duration of the SWDs, suggesting a quantitative GABA(A)ergic involvement in the mechanism(s) underlying the starting and stopping of an ongoing SWD. Also, vigabatrin decreased the SWD peak frequency, suggesting an important role of GABA(B) in the mechanism(s) underlying the peak frequency of the SWDs. Vigabatrin gradually changed the course of the hazard rates of the SWD durations, suggesting a qualitative GABAergic role in the mechanism(s) underlying the stopping of an ongoing SWD.
Bouwman
Brigitte M
BM
NICI/Department of Biological Psychology, Radboud University Nijmegen, 6500 HE Nijmegen, The Netherlands. gittebouwman@zonnet.nl
Suffczynski
Piotr
P
Midzyanovskaya
Inna S
IS
Maris
Eric
E
van den Broek
Philip L C
PL
van Rijn
Clementina M
CM
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D000818:Animals; D030801:Animals, Genetically Modified; D000927:Anticonvulsants / Q000494:pharmacology*; D016001:Confidence Intervals; D004569:Electroencephalography / Q000187:drug effects*; D008297:Male; D051381:Rats; D013997:Time Factors; D020888:Vigabatrin / Q000494:pharmacology*
D000927:Anticonvulsants; D020888:Vigabatrin