Antinociceptive and anti-inflammatory steroidal saponins from Dracaena ombet.
Two new steroidal saponins, namely (25R)-5beta-spirostan-3-beta-ol 3-O-beta-D-galactopyranosyl-(1'''-->4'')-O-beta-D-galactopyranosyl-(1''-->3')-O-beta-D-glucopyranoside (2), and (25R)-5beta-spirostan-3-beta-ol 3-O-beta-D-galactopyranosyl-(1'''-->4'')-O-beta-D-glucopyranosyl-(1''-->3')-O-beta-D-glucopyranoside (3), together with six known constituents, have been isolated from the leaves of Dracaena ombet Kotschy & Peyr. (Dracaenaceae). The structures of the two saponins were established by chemical and physicochemical analyses, including FAB- and HR-ESI-MS and 2D NMR. The fraction rich in saponins showed significant analgesic and anti-inflammatory activities (at a high dose of 30 mg/kg b.w.) and non-significant antiulcer activities at the same doses.
Moharram
Fatma A
FA
Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Helwan, Egypt. famoharram1@hotmail.com
El-Shenawy
Siham M
SM
D019342:Acetic Acid; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D031409:Dracaena; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D007213:Indomethacin; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013047:Specific Pathogen-Free Organisms; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012503:Saponins; D002351:Carrageenan; D019342:Acetic Acid; D007213:Indomethacin