Repair of spinal cord injury by transplantation of olfactory ensheathing cells.
Repair of spinal cord injury requires that severed axons are able to regenerate. Regrowth of axons is impeded by the loss of astrocytic pathways caused at the time of injury. Ensheathing glial cells cultured from the adult olfactory system can be transplanted into lesions and mediate both regeneration of axons and recovery of function.
Raisman
Geoffrey
G
Spinal Repair Unit, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK. g.raisman@ion.ucl.ac.uk
D000818:Animals; D001369:Axons / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D009457:Neuroglia / Q000637:transplantation*; D009833:Olfactory Pathways / Q000166:cytology* / Q000637:transplantation*; D051381:Rats; D013119:Spinal Cord Injuries / Q000628:therapy*