Emergence of low level vancomycin resistance in MRSA.
One hundred and twenty methicillin resistant Staphylococcus aureus (MRSA) strains were checked for minimum inhibitory concenteration (MIC) of vancomycin. The results showed that 98 strains (81.7 %) had MIC < 4microg/mL, 18 strains (15 %) had MIC 8 microg/mL, and 4 (03.3%) had MIC 16 microg/mL which being borderline between sensitive (< 4microg/mL) and resistant (>32 microg/mL) values points towards possible emergence of low level vancomycin resistance in the organisms and may explain the reasons of delayed therapeutic success of vancomycin in S. aureus bacteraemia in some situations.
Assadullah
S
S
Department of Clinical Microbiology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir - 190 011, India.
Kakru
D K
DK
Thoker
M A
MA
Bhat
F A
FA
Hussain
N
N
Shah
A
A