BRAF in papillary thyroid carcinoma.
Novel genetic findings about papillary thyroid carcinoma identify BRAF gene as a subject of great interest. Involvement of BRAF gene in pathogenesis of PTC, diagnostic value and the putative prognostic significance of its T1799A mutation are summarized in this article. Furthermore, a particular attention is focused to the role of pre-operative detection of BRAF mutation in the FNAB specimens of thyroid nodules and to the use of this gene as target for an effective cancer therapy.
Lanzilotta
Salvatore Giovanni
SG
Istituto Tumori Giovanni Paolo, Bari, Italy.
Grammatica
Luciano
L
Paradiso
Angelo
A
Simone
Gianni
G
D000818:Animals; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004252:DNA Mutational Analysis; D006801:Humans; D009154:Mutation / Q000235:genetics; D011379:Prognosis; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D048493:Proto-Oncogene Proteins B-raf