DNA variation in MSR1, RNASEL and E-cadherin genes and prostate cancer in Poland.
BACKGROUND
We investigated whether or not inherited variation in MSR1, RNASEL and E-cadherin contribute to prostate cancer risk in Poland.


METHODS
We sequenced the coding region of these three genes in individuals from Poland and identified five common DNA variants (R462Q and D541E in RNASEL, R293X and P275A in MSR1, and 2076C>T (A692A) in E-cadherin). These five variants and the -160C>A promoter change in E-cadherin were genotyped in 737 prostate cancer cases and 511 controls.


RESULTS
The frequencies of genotyped variants in MSR1, RNASEL and E-cadherin genes in cases and controls were similar. We did not see any association for the studied variants when cases were stratified by age of diagnosis, by family history, by prostate-specific antigen level at the time of diagnosis, by Gleason sore or by tumor stage.


CONCLUSIONS
Inherited variation in RNASEL, MSR1 and E-cadherin genes do not seem to contribute to prostate cancer development in Poland.
Cybulski
Cezary
C
International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Wokołorczyk
Dominika
D
Jakubowska
Anna
A
Gliniewicz
Bartłomiej
B
Sikorski
Andrzej
A
Huzarski
Tomasz
T
Debniak
Tadeusz
T
Narod
Steven A
SA
Lubiński
Jan
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D004722:Endoribonucleases / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D051117:Scavenger Receptors, Class A / Q000235:genetics*
D015820:Cadherins; D004273:DNA, Neoplasm; C495139:MSR1 protein, human; D051117:Scavenger Receptors, Class A; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease