title: Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second.
abstract: A Fourier domain mode-locked (FDML) laser at 1050 nm for ultra-high-speed optical coherence tomography (OCT) imaging of the human retina is demonstrated. Achievable performance, physical limitations, design rules, and scaling principles for FDML operation and component choice in this wavelength range are discussed. The fiber-based FDML laser operates at a sweep rate of 236 kHz over a 63 nm tuning range, with 7 mW average output power. Ultra-high-speed retinal imaging is demonstrated at 236,000 axial scans per second. This represents a speed improvement of approximately10x over typical high-speed OCT systems, paving the way for densely sampled volumetric data sets and new imaging protocols.
authors.affiliation: Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. Robert.Huber@Physik.Uni-Muenchen.de
authors.forename: R
authors.initials: R
authors.lastname: Huber
authors.forename: D C
authors.initials: DC
authors.lastname: Adler
authors.forename: V J
authors.initials: VJ
authors.lastname: Srinivasan
authors.forename: J G
authors.initials: JG
authors.lastname: Fujimoto
mesh_terms: D004867:Equipment Design; D005583:Fourier Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D007834:Lasers; D055095:Optics and Photonics; D012160:Retina / Q000378:metabolism / Q000473:pathology*; D012171:Retinal Vessels / Q000473:pathology; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*