title: Gastrointestinal stromal tumor of the rectum with liver metastasis: report of a case.
abstract: Gastrointestinal stromal tumors (GISTs) have unique immunohistochemical and molecular genetic features that set them apart from leiomyomas, leiomyosarcomas, and schwannomas. Although recurrence of GIST usually tends to develop locally or in the liver, rectal GIST reoccur predominantly at the original site of the tumor. We describe a rare case of rectal GIST with multiple liver metastases. We carried out immunohistochemical staining for p53 protein, proliferating cell nuclear antigen (PCNA), integrins, and interleukin-1 receptor type I (IL-1RI) in order to investigate the degree of malignancy of this neoplasm in addition to the immunohistochemical analyses that were necessary for diagnosing GIST. Histologically, the rectal tumor was classified as an uncommitted type of rectal GIST with multiple liver metastases. Positive immunostaining for PCNA, alpha6 integrin subunit, and IL-1RI was found in both the rectal and hepatic tumors. The patients with a rectal GIST may have an increased risk of liver metastasis and a poor prognosis independent of the size of the tumor.
authors.affiliation: Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan. cb8h-swi@asahi-net.or.jp
authors.forename: Hirozumi
authors.initials: H
authors.lastname: Sawai
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Funahashi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Moritsugu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takeyama
authors.forename: Tadao
authors.initials: T
authors.lastname: Manabe
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology* / Q000556:secondary; D006801:Humans; D007150:Immunohistochemistry; D039503:Integrin alpha6 / Q000032:analysis; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000556:secondary; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D053573:Receptors, Interleukin-1 Type I / Q000032:analysis; D012004:Rectal Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D039503:Integrin alpha6; D018809:Proliferating Cell Nuclear Antigen; D053573:Receptors, Interleukin-1 Type I; D016159:Tumor Suppressor Protein p53