Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX.
In a step toward clarifying how acute viral infections provoke the host DNA damage response, Tarakanova et al. (2007) characterized a gamma-herpesvirus protein, which phosphorylates histone H2AX during infection, suggesting that the virus actively initiates and benefits from the host DNA damage response.
Xie
Anyong
A
Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Scully
Ralph
R
Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Electronic address: rscully@bidmc.harvard.edu.
D000818:Animals; D004249:DNA Damage; D018142:Gammaherpesvirinae / Q000235:genetics* / Q000378:metabolism* / Q000472:pathogenicity; D006566:Herpesviridae Infections / Q000378:metabolism / Q000821:virology; D006657:Histones / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D016366:Open Reading Frames; D010766:Phosphorylation; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication / Q000502:physiology*
D006657:Histones; D014764:Viral Proteins