Pigment epithelium-derived factor (PEDF) inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties.
Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis, suggesting that loss of this factor may be involved in angiogenic eye disease. Here, we show that PEDF inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties. Our present study suggests that PEDF may play a protective role against atherosclerosis.
Yamagishi
Sho-ichi
S
Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Japan. shoichi@med.kurume-u.ac.jp
Matsui
Takanori
T
Nakamura
Kazuo
K
Imaizumi
Tsutomu
T
D000804:Angiotensin II / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism*; D002460:Cell Line; D049109:Cell Proliferation; D005136:Eye Proteins / Q000378:metabolism* / Q000494:pharmacology; D032389:Myocytes, Smooth Muscle / Q000166:cytology* / Q000378:metabolism; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018919:Neovascularization, Physiologic; D009414:Nerve Growth Factors / Q000378:metabolism* / Q000494:pharmacology; D009861:Onium Compounds / Q000494:pharmacology; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015843:Serpins / Q000378:metabolism* / Q000494:pharmacology; D000099174:Pigment Epithelium-Derived Factor
D000804:Angiotensin II; D000975:Antioxidants; D005136:Eye Proteins; D019255:NADPH Oxidases; D009414:Nerve Growth Factors; D009861:Onium Compounds; D017382:Reactive Oxygen Species; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor; C007517:diphenyleneiodonium