[Immunological role of progesterone in the maintenance of pregnancy].
Progesterone is an essential hormone for pregnancy maintenance. This hormone acts by binding to its intracellular receptor or by rapid non-genomic actions to regulate a wide variety of biological functions in the feto-placental unit. Progesterone regulates blastocyst implantation and placental development by inducing immunosuppression through type Th2 cytokines secretion. This review summarizes current research about the role of progesterone as critical regulator of expression and secretion of cytokines by T-cell and other placental cells.
Barrera
David
D
Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, México, D F. barrera1912@gmail.com
Avila
Euclides
E
Díaz
Lorenza
L
D000818:Animals; D001755:Blastocyst; D016207:Cytokines / Q000502:physiology; D010064:Embryo Implantation / Q000276:immunology / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation; D007108:Immune Tolerance; D007249:Inflammation; D007743:Labor, Obstetric / Q000502:physiology; D008214:Lymphocytes / Q000378:metabolism; D008431:Maternal-Fetal Exchange / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D016328:NF-kappa B / Q000502:physiology; D010920:Placenta / Q000276:immunology; D010929:Placentation; D011247:Pregnancy; D011255:Pregnancy Maintenance / Q000276:immunology* / Q000502:physiology; D011257:Pregnancy Proteins / Q000502:physiology; D011374:Progesterone / Q000502:physiology*; D011980:Receptors, Progesterone / Q000502:physiology; D013154:Spleen / Q000378:metabolism; D013491:Suppressor Factors, Immunologic; D018418:Th2 Cells / Q000378:metabolism
D016207:Cytokines; D016328:NF-kappa B; C110058:PIBF1 protein, human; C491677:Pibf1 protein, mouse; D011257:Pregnancy Proteins; D011980:Receptors, Progesterone; D013491:Suppressor Factors, Immunologic; D011374:Progesterone