[Antibiotic prophylaxis in acute pancreatitis].
In most patients, acute pancreatitis (AP) is a mild self-limiting disease, however for about 20% patients with clinically severe acute pancreatitis it is a live treating disease with 30% mortality. Mortality increases in patient with sterile necrosis and especially when infection has occurred. Prevention and optimal treatment of infection in AP have become a principal therapeutic target for improving the outcome of this disease. Several controlled clinical trials, often controversial, demonstrated a significant reduction of hospital mortality. In this article, we review the current opinion of the antibiotics treatment in AP.
Degowska
Małgorzata
M
Klinika Chorób Wewnetrznych i Gastroenterologii CSK MSWiA w Warszawie. mdegowska@cskmswia.pl
Rydzewska
Grazyna
G
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D009181:Mycoses / Q000209:etiology / Q000517:prevention & control; D010195:Pancreatitis / Q000150:complications / Q000188:drug therapy*; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications / Q000188:drug therapy*; D015163:Superinfection / Q000382:microbiology / Q000517:prevention & control*; D015996:Survival Rate
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents