Functional study in NSE-Hu-Bcl-2 transgenic mice: a model for retinal diseases starting in Müller cells.
In NSE-Hu-Bcl-2 transgenic mice, line 71, retina undergoes early postnatal degeneration linked to the prior death of Müller cells. The purpose of this study was to complete the characterization of this retinal dysfunction by using electroretinographic (ERG) recordings in both scotopic and photopic conditions. Here, we showed that both rod and cone systems were profoundly affected in NSE-Hu-Bcl-2 transgenic mice as soon as 15 postnatal days in accordance with histological study performed previously.
Department of Basic Neuroscience, Medical School, University of Geneva, Geneva, Switzerland.
Cécile
C
Péant
André
A
Dosso
Lorenza
L
Eder-Colli
Florence
F
Chiodini
D000221:Adaptation, Ocular; D000818:Animals; D000831:Animals, Newborn; D016923:Cell Death; D003623:Dark Adaptation; D004195:Disease Models, Animal; D004596:Electroretinography; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D010751:Phosphopyruvate Hydratase / Q000235:genetics; D011401:Promoter Regions, Genetic; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism*; D012160:Retina / Q000473:pathology* / Q000503:physiopathology*; D017949:Retinal Cone Photoreceptor Cells / Q000503:physiopathology; D012162:Retinal Degeneration / Q000209:etiology / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology*; D017948:Retinal Rod Photoreceptor Cells / Q000503:physiopathology
D019253:Proto-Oncogene Proteins c-bcl-2; D010751:Phosphopyruvate Hydratase