The nuclear life of nucleoporins.
Nucleoporins are the constituents of the nuclear pore complex, but they are also known to shuttle to the nuclear interior, the function of which is unclear. In a recent issue of Nature Cell Biology, Wang et al.'s mechanistic studies of leukemogenic fusion proteins that contain nucleoporins suggest that they have a direct role in transcription.
Department of Tumor Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.
Bernike
B
Kalverda
Maarten
M
Fornerod
D002467:Cell Nucleus / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000378:metabolism; D008954:Models, Biological; D028861:Nuclear Pore Complex Proteins / Q000737:chemistry / Q000378:metabolism*; D020449:Repetitive Sequences, Amino Acid; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D014158:Transcription, Genetic
D018398:Homeodomain Proteins; D028861:Nuclear Pore Complex Proteins; C093350:nuclear pore complex protein 98