Studies on gynecological hydrophilic lactic acid preparations. Part 8: use of chitosan as lactic acid carrier in intravaginal tablets.
Hydrophilic intravaginal tablets based on methylcellulose and containing lactic acid component with chitosan undergo swelling under standard conditions. A high flow-limit of the gel that originates from the tablets as well as its dynamic viscosity should allow for the durable dosage form in the vagina. By choosing the 1:1 ratio of lactic acid to chitosan, it is possible to obtain tablets disintegrating into a gelform at physiological pH range of 3.8-4.4. An increase in the amount of lactic acid in the complex in relation to the polymer up to 2:1 and 3:1 ratios results in gels with a lower pH. These gels possess an acid reserve that might act to neutralize the excess of alkali present in severe vaginal infections.
Małolepsza-Jarmołowska
Katarzyna
K
Department of Pharmaceutical Technology, Faculty of Pharmacy, The Silesian Piasts Memorial Medical University of Wrocław, 38 Szewska Str., 50-139 Wrocław, Poland.
D000269:Adhesives; D000282:Administration, Intravaginal; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000008:administration & dosage / Q000737:chemistry*; D008747:Methylcellulose / Q000737:chemistry; D013607:Tablets; D014621:Vagina / Q000737:chemistry; D014783:Viscosity
D000269:Adhesives; D004337:Drug Carriers; D005782:Gels; D013607:Tablets; D019344:Lactic Acid; D008747:Methylcellulose; D048271:Chitosan