Recently described and emphasized entities of renal neoplasms.
BACKGROUND
Recent advances of molecular biology and cytogenetics of renal cancer have resulted in the new classification of renal neoplasms and a number of subtypes are identified and emphasized. In addition, rare nonepithelial renal neoplasms are identified and characterized. Familiarity with these entities will help make the most accurate diagnosis and guide the treatment and follow-up of patients with renal neoplasm.


OBJECTIVE
To review the clinicopathologic entities of renal neoplasms that are recently defined or emphasized. Their clinical, gross, microscopic, and immunohistochemical features, as well as specific cytogenetic or molecular abnormalities, are discussed. Important differential diagnoses of each entity are also briefly discussed.


METHODS
Extensive review of published literature and our experience.


CONCLUSIONS
A number of new entities of renal neoplasms or genetically defined renal cell carcinomas have been identified or emphasized because of their unique genetic or molecular changes. Recognition of these entities becomes important as some of them have different biologic behavior and treatment strategies may be different.
Department of Pathology, The Methodist Hospital, 6565 Fannin St, Houston, TX 77030, USA. stevenshen@tmh.tmc.edu
Steven S
SS
Shen
Luan D
LD
Truong
Alberto G
AG
Ayala
Jae Y
JY
Ro
D014408:Biomarkers, Tumor / Q000032:analysis; D002869:Chromosome Aberrations; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000145:classification / Q000473:pathology*; D008967:Molecular Biology / Q000639:trends
D014408:Biomarkers, Tumor