[Role of viscosity and permeability of erythrocyte plasmatic membrane in controlling the oxygen transport effectiveness by human hemoglobin on completion of space flight].
Plasmatic membrane viscosity and permeability and hemoporphyrine conformation in human hemoglobin were studied on completion of long-duration space flight (LSF). Reversible increases in viscosity and selective permeability (Na+/H+ -turnover) of erythrocyte plasmatic membrane were observed immediately after and in the period of recovery from LSF. Viscosity of lipids in both external and internal locations of plasmatic membrane in human erythrocytes was changed after LSF. The reversible rise of the Na+/H+ -turnover is likely to alter intracellular pH and oxygen binding with hemoglobin. The former is confirmed by the concurrent reversible decline in the deoxyhemoglobin ability to bind oxygen and the oxyhemoglobin ability to retain oxygen. In LSF and during readaptation to the normal gravity blood levels of hemoglobin and free iron are known to be reduced and may be answerable for the hypoxic state of human organism.
Ivanova
S M
SM
Maksimov
G V
GV
Morukov
B V
BV
Iarlykova
Iu V
IuV
Labetskaia
O I
OI
Luneva
O G
OG
Maksimova
N V
NV
Brazhe
N A
NA
Bryzgalova
N Iu
NIu
Parshina
E Iu
EIu
D001809:Blood Viscosity / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000502:physiology*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007124:Immunoenzyme Techniques; D007424:Intracellular Fluid / Q000378:metabolism; D017136:Ion Transport; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D013026:Space Flight
D006454:Hemoglobins; D010100:Oxygen