Survivin expression correlates with unfavourable prognoses in invasive ductal carcinoma of the breast.
Survivin is a 16.5-kDa intracellular protein also known as AP14 or BIRC5. It inhibits apoptosis and regulates cell division and belongs to the inhibitors of apoptosis (IAP) gene family. In the majority of neoplasms investigated for survivin expression, high levels of the IAP proteins were predictive of tumour progression, either in terms of disease-free survival or overall survival, thus providing significant prognostic information. Hence, the prognostic value of survivin expression in tumour masses of invasive ductal carcinoma has been investigated. It was found that negative and low expression of survivin correlated significantly with favourable outcomes. Conversely, high expression correlated with unfavourable outcomes. The five-year survival rate was higher among the cases with low and negative survivin expression, compared to those with higher survivin expression. However, this correlation was found to be insignificant statistically. Furthermore, a statistical model has been devised to explain the combined effects of survivin expression and its sub-cellular localisation, p-53 expression and lymph nodal involvement, on the outcomes of these patients.
Al-Joudi
F S
FS
School of Dental Sciences, University of Science of Malaysia.
Iskandar
Z A
ZA
Imran
A K
AK
D001943:Breast Neoplasms / Q000503:physiopathology*; D018270:Carcinoma, Ductal, Breast / Q000503:physiopathology*; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008485:Medical Audit; D008869:Microtubule-Associated Proteins / Q000032:analysis* / Q000037:antagonists & inhibitors; D009363:Neoplasm Proteins / Q000032:analysis* / Q000037:antagonists & inhibitors; D011379:Prognosis; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin