Dicing with viruses: microRNAs as antiviral factors.
In plants and invertebrates, Dicer genes play a critical role against infections by RNA viruses. In this issue, Otsuka et al. (2007) report that Dicer mutant mice are hypersusceptible to infection by the RNA virus VSV.
Faculté des Sciences de la Vie, Université Louis Pasteur, F-67070 Strasbourg, France.
Stefanie
S
Müller
Jean-Luc
JL
Imler
D000818:Animals; D053487:DEAD-box RNA Helicases / Q000502:physiology*; D004722:Endoribonucleases / Q000502:physiology*; D035683:MicroRNAs / Q000502:physiology*; D034622:RNA Interference / Q000502:physiology*; D012327:RNA Virus Infections / Q000201:enzymology* / Q000517:prevention & control* / Q000821:virology; D043244:Ribonuclease III / Q000096:biosynthesis / Q000502:physiology*
D035683:MicroRNAs; D004722:Endoribonucleases; C509781:Dicer1 protein, mouse; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases