The role of cognitive control in cocaine dependence.
While hedonic and reward-related processes are central to drug use and dependence, this article focuses on the contribution that cognitive processes may make to addiction. In particular, attention is drawn to those processes involved in exercising control over behavior as drug dependence is characterized by risky, impulsive behavior. Functional neuroimaging implicates prefrontal deficits in cocaine dependence with an emerging picture of cocaine users having attentional biases towards drug-related stimuli, poor performance in laboratory tests of inhibitory control, and compromised monitoring and evaluation of their behavior. Combined, these deficits may contribute to the continuation of use in dependent individuals and may qualify as important targets for therapeutic interventions.
School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland. Hugh.Garavan@tcd.ie
Hugh
H
Garavan
Robert
R
Hester
D001288:Attention / Q000502:physiology; D016739:Behavior, Addictive / Q000209:etiology* / Q000473:pathology; D019970:Cocaine-Related Disorders / Q000150:complications* / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests / Q000706:statistics & numerical data