A finite element method for growth in biological development.
We describe finite element simulations of limb growth based on Stokes flow models with a nonzero divergence representing growth due to nutrients in the early stages of limb bud development. We introduce a "tissue pressure" whose spatial derivatives yield the growth velocity in the limb and our explicit time advancing algorithm for such tissue flows is described in de tail. The limb boundary is approached by spline functions to compute the curvature and the unit outward normal vector. At each time step, a mixed hybrid finite element problem is solved, where the condition that the velocity is strictly normal to the limb boundary is treated by a Lagrange multiplier technique. Numerical results are presented.
Murea
Cornel M
CM
Laboratoire de Mathématiques, Informatique et Applications, Université de Haute-Alsace, 4, rue des Fréres Lumiére, 68093 Mulhouse Cedex, France. cornel.murea@uha.fr
Hentschel
H G E
HG
D000818:Animals; D003198:Computer Simulation; D005121:Extremities / Q000196:embryology* / Q000254:growth & development*; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological; D038081:Organogenesis / Q000502:physiology*; D014714:Vertebrates / Q000196:embryology* / Q000254:growth & development*