Synthesis and biological activity of mixed ligand dioxouranium(VI) and thorium(IV) complexes.
Mixed ligand complexes of dioxouranium(VI) and thorium(IV) in the proportion 1:1:1 and 1:2:1 have been synthesized using 8-hydroxyquinoline as a primary ligand and L-proline and 4-hydroxy-L-proline as secondary ligands, respectively. The metal complexes have been characterized on the basis of elemental analysis, molar conductance, magnetic, spectral and thermal studies. The molar conductance studies of the complexes in DMF at 10(-3) M concentrations indicate their non-electrolytic nature. Room temperature magnetic susceptibility measurements revealed diamagnetic nature of the complexes. Electronic absorption spectra of the complexes show intra-ligand and charge transfer transitions, respectively. The thermal analysis data of the complexes indicates the presence of a coordinated water molecule/molecules. The tube dilution method has been used to study the antibacterial activity of the complexes against the pathogenic bacteria Staphylococcus aureus and Escherichia coli. The results have been compared against those of control tetracycline, which was screened simultaneously. The complexes have been screened for in vitro cytotoxicity (IC50) studies against Ehrlich ascites cells and Dalton's lymphoma ascites cells, respectively.
Thakur
Ganesh A
GA
Department of Chemistry, Mahatma Phule A. S. C. College, Panvel, Dist. Raigad (Maharashtra) 410206, India.
Athlekar
Shrikant V
SV
Dharwadkar
Sanjiv R
SR
Shaikh
Manzoor M
MM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor; D045744:Cell Line, Tumor; D004055:Differential Thermal Analysis; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006909:Hydroxyproline / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008024:Ligands; D008280:Magnetics; D010087:Oxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015125:Oxyquinoline / Q000737:chemistry; D011392:Proline / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013910:Thorium / Q000737:chemistry* / Q000494:pharmacology; D014501:Uranium / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D008024:Ligands; D010087:Oxides; C510902:dioxouranium(VI); D014501:Uranium; D015125:Oxyquinoline; D013910:Thorium; D011392:Proline; D006909:Hydroxyproline