[Clinical survey of prostate cancer].
OBJECTIVE
Treatment trends and outcomes for prostate cancer in our hospital were reported.


METHODS
A total of 482 patients with prostate cancer treated in our hospital between January, 1990 and December, 2004.


RESULTS
The age distribution was from 51 to 99 years-old, with the mean age of 72.9 years-old at onset. The number of prostate cancer patients, especially asymptomatic patients with PSA elevation, have increased recently. As for the clinical stage, 92 cases (19.1%), 238 cases (49.4%), 48 cases (10.0%) and 104 cases (21.6%) were stage A, B, C and D, respectively. 425 cases (88.2%) received some form of endocrine therapy. Retropubic prostatectomy or external beam radiation therapy was performed in 77 and 57 cases, respectively all cases. The cause-specific 5-year survival rate of the 482 cases was 79.7%, comprising 100% for stage A1, 96.8% for stage A2, 89.4% for stage B, 79.9% for stage C and 42.9% for stage D. The cause-specific 5-year survival was significantly better in the latter patients (1997-2004) than the former patients (1990-1996) in stage C (p = 0.0226), D (p = 0.0448). In stage C patients, the retropubic prostatectomy (with endocrine therapy) group, increased in the latter period and showed longer cause-specific 5-year survival than the endocrine therapy group (p = 0.0027). In stage D2 patients, chemo-endocrine therapy with VP-16, ADM and CDDP refractory and cause-specific 5-year survival was longer than endocrine therapy alone (p = 0.0467, P = 0.0381).


CONCLUSIONS
Our results suggest that retropubic prostatectomy with endocrine therapy and chemo-endocrine therapy are useful for stage C and D prostate cancer patients, respectively.
Department of Urology, Osaka Police Hospital, Osaka, Japan.
Tsuyoshi
T
Takada
Koji
K
Hatano
Mototaka
M
Satoh
Yuichi
Y
Tsujimoto
Masahito
M
Honda
Kiyomi
K
Matsumiya
Hideki
H
Fujioka
D000230:Adenocarcinoma / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011468:Prostatectomy / Q000401:mortality / Q000706:statistics & numerical data; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate