Orofacial pain - a presenting symptom of bisphosphonate associated osteonecrosis of the jaws.
Osteonecrosis of the jaws (ONJ) associated with bisphosphonate therapy is being reported with increasing frequency all over the world. Pain may be the presenting symptom commonly associated with intra-oral bone exposure. The aetiology of this therapeutic complication is still not well understood. Three cases are presented and the management of the condition is discussed.
Srinivasan
D
D
Maxillofacial Surgery, New Cross Hospital, Wednesfield Road, Wolverhampton, WV10 0QP. godilip@yahoo.co.uk
Shetty
S
S
Ashworth
D
D
Grew
N
N
Millar
B
B
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D002710:Chlorhexidine / Q000627:therapeutic use; D004164:Diphosphonates / Q000009:adverse effects*; D005157:Facial Pain / Q000209:etiology*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects; D007571:Jaw Diseases / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy; D013752:Tetracycline / Q000627:therapeutic use; D000077211:Zoledronic Acid
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D013752:Tetracycline; D002710:Chlorhexidine