Demineralized bone matrix composite grafting for posterolateral spinal fusion.
In a prospective series, the 24-month fusion status was evaluated radiographically among patients undergoing instrumented posterolateral lumbosacral spinal fusion. Seventy-three patients had a diagnosis of degenerative disk disease or degenerative spondylolisthesis and had supplemental bone grafting with demineralized bone matrix (DBM) putty (Grafton DBM; Osteotech, Eatontown, NJ) enriched with aspirated bone marrow (DBM bone marrow), DBM putty combined with iliac crest autograft (DBM autograft), or autograft. Overall, approximately 63% (12 of 19) of DBM bone marrow, 70% (19 of 27) of DBM autograft, and 67% (18 of 27) of autograft patients were fused at 24 months (P = .875). These findings suggest that both DBM composites offer similar performance to autograft in posterolateral spinal fusion.
Department of Orthopedics, Thomas Jefferson University, Philadelphia, PA, USA.
Alexander R
AR
Vaccaro
Harrison A
HA
Stubbs
Jon E
JE
Block
D018775:Bone Demineralization Technique; D016026:Bone Marrow Transplantation; D018786:Bone Substitutes / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007085:Ilium / Q000637:transplantation; D017116:Low Back Pain / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010148:Intractable Pain / Q000601:surgery; D011446:Prospective Studies; D013123:Spinal Fusion / Q000379:methods*; D014182:Transplantation, Autologous; D016896:Treatment Outcome
D018786:Bone Substitutes