Effect of docosahexaenoic acid on macrophage functions of rats.
Docosahexaenoic acid (DHA) is an omega-3 fatty acid which has been demonstrated to exhibit anti-inflammatory effects. The objective of this study was to determine the effect of DHA on phagocytic and chemotactic activities of peritoneal macrophages obtained from rats. DHA was dissolved in 1 ml of corn oil at dose of 36 mg/kg/day and given via oral gavage for 4 weeks. Control rats received 1 ml/day corn oil as vehicle. At the end of the treatment period, peritoneal macrophages were isolated and chemotactic and phagocytic activities were assayed. Chemotactic and phagocytic activities were reduced in rats fed with DHA. These results demonstrated the effect of DHA in modulating immune activities of rat peritoneal macrophages.
Department of Physiology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey.
Mehmet
M
Bulbul
Ruken
R
Tan
Burcu
B
Gemici
Gülay
G
Hacioglu
Aysel
A
Agar
V Nimet
VN
Izgut-Uysal
D000818:Animals; D002633:Chemotaxis / Q000187:drug effects*; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology*; D008297:Male; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D004281:Docosahexaenoic Acids