The role of type I interferons in TLR responses.
Recent advances in unravelling the complexities of the signalling pathways that constitute innate immunity have highlighted type I interferon as a key component in the response to infection. Here we focus on the emerging field of pattern-recognition receptor signalling, specifically Toll-like receptors and retinoic acid inducible gene-like helicases, from the perspective of this 50-year-old cytokine. The type I interferon gene family encompasses more than 20 subtypes, whose nature and properties have been extensively studied during its relatively long history. In this review we update and integrate available data on the mechanics of activation of the interferon genes and the role of this cytokine family in the innate immune response.
Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Parkville, Victoria, Australia.
Susie J
SJ
Noppert
Katherine A
KA
Fitzgerald
Paul J
PJ
Hertzog
D000818:Animals; D001483:Base Sequence; D003141:Communicable Diseases / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000235:genetics / Q000276:immunology*; D008969:Molecular Sequence Data; D017471:Receptors, Interferon / Q000276:immunology; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology*; D014158:Transcription, Genetic
D007370:Interferon Type I; D017471:Receptors, Interferon; D051193:Toll-Like Receptors