Mitochondrial DNA transcription: regulating the power supply.
In this issue of Cell, Park et al. (2007) describe the nuclear encoded protein MTERF3 as a negative regulator of mitochondrial DNA transcription initiation. This study highlights a mechanism by which mitochondrial DNA transcription (and therefore oxidative phosphorylation) may be regulated in response to alterations in the cell's physiological and metabolic demands.
Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Newcastle University, Newcastle upon Tyne, UK.
Robert W
RW
Taylor
Douglass M
DM
Turnbull
D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000473:pathology; D024101:Mitochondrial Proteins / Q000378:metabolism; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure; D009928:Organ Specificity; D014158:Transcription, Genetic
D004272:DNA, Mitochondrial; D024101:Mitochondrial Proteins