[Gene expression profile changes in oral verrucous carcinoma and oral squamous cell carcinoma].
OBJECTIVE
To determine the difference in the gene expression between human oral verrucous carcinoma (OVC) and oral squamous cell carcinoma (OSCC).


METHODS
cDNA chip was used to detect the mRNA of cancer tissue from 4 OVC and 4 OSCC. After profile blotted and handled by bioinformation, the gene expression of these two kinds of lesions was examined.


RESULTS
Using the BioStarH-40 profile, 593 different expression of genes was found. The rate of different genes was 15.2%, of which the expression of 283 genes increased (59 genes significantly increased) and 310 genes decreased (98 genes significantly decreased) in OVC tissue than that in OSCC.


CONCLUSIONS
The gene expression of OVC and OSCC was different, which many contribute to the different biological behavior of these two kinds of lesions.
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410078, China. tangzhangui@yahoo.com.cn
Zhan-gui
ZG
Tang
Su-ping
SP
Zhao
Lei
L
Zhang
Xiao-ling
XL
Li
D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D018289:Carcinoma, Verrucous / Q000235:genetics*; D020869:Gene Expression Profiling; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis