Dexmedetomidine for pediatric MRI sedation: a review of a series of cases.
BACKGROUND
The aim of this review was to determine whether dexmedetomidine alone provided satisfactory conditions for children undergoing magnetice resonance imaging (MRI).


METHODS
A retrospective review of 21 patients was undertaken, (age range: 1-8 years, weight 10-27 kg) who received dexmedetomidine to provide deep sedation for an MRI procedure.


RESULTS
In the initial eight patients who received dexmedetomidine (bolus 0.5-1.5 mg.kg(-1) and infusion rate 1-1.5 mg.kg(-1).h(-1)) by itself, movement occurred in five of them, even when the maximum suggested dose was used (1 microg.kg(-1).h(-1)). Midazolam (0.1 mg.kg(-1)) i.v. was given as an adjunct to the following 13 patients (dexemdetomidine doses were lower: bolus 1 mg.kg(-1), infusion 0.5-1 mg.kg(-1).h(-1)). Only one patient moved within this group. The mean time to discharge postprocedure was 90 min. There were no differences with respect to recovery or discharge times between those who did or did not receive midazolam. No cardiac or respiratory complications were noted.


CONCLUSIONS
The use of dexmedetomidine for MRI sedation by itself was more unpredictable than anticipated from the published case reports of its use.
Heard
Christopher M B
CM
State University of New York at Buffalo, Department of Anesthesiology and Division of Pediatric Critical Care Medicine, and Department of Pharmacy, Women and Children's Hospital of Buffalo, NY 14222, USA. cheard@upa.chob.edu
Joshi
Prashant
P
Johnson
Kristin
K
D002648:Child; D002675:Child, Preschool; D020927:Dexmedetomidine / Q000009:adverse effects; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009068:Movement / Q000187:drug effects; D015742:Propofol; D012189:Retrospective Studies
D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D015742:Propofol