Early abstinence in cocaine dependence: influence of comorbid major depression.
Cocaine dependence (CD) is often accompanied by major depressive disorder (MDD). The comorbid condition (CD + MDD) is especially difficult to treat, with relapse possibly made more likely by intensified dysphoria during abstinence in the setting of MDD. We studied treatment-seeking CD + MDD volunteers, currently depressed, and a comparison CD group over three days of inpatient monitored abstinence. At admission, Beck Depression Inventory (BDI) and anxiety scores differed significantly between groups. By Day 3, BDI scores improved for both CD and CD + MDD groups. The mood response to cocaine cessation among CD + MDD individuals resembled that of CD participants, contrary to some expectations.
Division on Substance Abuse, Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York 10032, USA. er22@columbia.edu
Eric
E
Rubin
Efrat
E
Aharonovich
Adam
A
Bisaga
Frances R
FR
Levin
Wilfrid N
WN
Raby
Edward V
EV
Nunes
D000328:Adult; D019970:Cocaine-Related Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening / Q000379:methods; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data; D010349:Patient Compliance / Q000706:statistics & numerical data*; D010507:Periodicity; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors