Water-soluble pH-responsive dendritic core-shell nanocarriers for polar dyes based on poly(ethylene imine).
A simple general synthetic concept to build dendritic core-shell architectures with pH-labile linkers based on hyperbranched PEI cores and biocompatible PEG shells is presented. Using these dendritic core-shell architectures as nanocarriers, the encapsulation and transport of polar dyes of different sizes is studied. The results show that the acid-labile nanocarriers exhibit much higher transport capacities for dyes than unfunctionalized hyperbranched PEI. The cleavage of imine bonds and controlled release of the polar dyes revealed that weak acidic condition (pH approximately 5.0) could cleave the imine bonds linker and release the dyes up to five times faster than neutral conditions (pH = 7.4).
Xu
Shangjie
S
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.
Luo
Ying
Y
Haag
Rainer
R
D001547:Benzaldehydes / Q000138:chemical synthesis / Q000737:chemistry; D004396:Coloring Agents / Q000737:chemistry*; D003224:Congo Red / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry*; D012395:Rose Bengal / Q000737:chemistry; D012995:Solubility; D013329:Structure-Activity Relationship; D013944:Thymolphthalein / Q000031:analogs & derivatives / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry*
D001547:Benzaldehydes; D004396:Coloring Agents; D050091:Dendrimers; D004337:Drug Carriers; D014867:Water; D012395:Rose Bengal; D003224:Congo Red; D011092:Polyethylene Glycols; C013713:thymol blue; D011094:Polyethyleneimine; C032175:benzaldehyde; D013944:Thymolphthalein