[When and what will we do with the descendants of colorectal cancer patients? Case study and research project presentation].
The polygenic etiology of familial colorectal cancer and other digestive tract cancers has been acknowledged and therefore a study subject by means of various techniques such comparative genomic hybridization, serial genetic analysis (APC, CGH) or DNA arrays. Our paper is the first presentation of a CNCSIS research project named: "Analiza unor factori moleculari implicaţi in stabilirea riscului statistic de îmbolnăvire la descendentii probanzilor cu cancer rectocolonic" and also presents the case of a 12 members family in which 3 had already been diagnosed with colonic or rectal cancer. The APC gene methylation profile was studied in order to establish both the gene implication in cancer development within the family and the risk of colorectal cancer for the healthy family members. The paper shows the present means of interaction between the surgeon and the familial colorectal cancer cases and the research project advocates for the necessity of a genetic counseling network to which such cases should be referred.
Beluşică
L
L
Clinica Chirurgie Generală I. Juvara, Spitalul Clinic I. Cantacuzino. laurentiubelusica@gmail.com
Cimponeriu
D
D
Dumitrescu
Ioana
I
Gherghinoiu
Roni
R
Hortopan
Andreea
A
Constantinescu
G
G
Predescu
Gabriela
G
Doran
H
H
Pătraşcu
Tr
T
D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D000328:Adult; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D019175:DNA Methylation; D017809:Fatal Outcome; D005260:Female; D017491:Genes, APC; D005817:Genetic Counseling; D005819:Genetic Markers; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis; D010375:Pedigree; D018570:Risk Assessment; D016896:Treatment Outcome
D005819:Genetic Markers