Polysaccharide formulation for improvement of racemic vitamin E bioavailability.
The relative bioavailability of polysaccharide--racemic vitamin E preparation in comparison with a commercial product was assessed in a kinetic study of plasma alpha-tocopherol in rabbits. Six male rabbits were used in a cross-over design. Alpha-Tocopherol levels were determined by the fluorometric method. A secondary peak in alpha-Tocopherol plasma concentration--time profiles was observed in connection with enterohepatic circulation of vitamin E. A simple one-compartment pharmacokinetic model was proposed to explain enterohepatic circulation of alpha-tocopherol in rabbits. On the basis of the results obtained, it is apparent that polysaccharide--vitamin E preparation achieved a higher rate and extent of absorption. The total AUC of experimental preparation was 1.78-fold greater than that of a commercial capsule preparation, suggesting an increase of bioavailability by 78%.
Department of Applied Pharmacy, Medical University of Lublin, ul. Chodźki 1, 20-093 Lublin, Poland. zluke@poczta.fm
Łukasz
Ł
Zimmer
Wiktor
W
Czarnecki
D000284:Administration, Oral; D000688:Amylose / Q000737:chemistry; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002214:Capsules; D018592:Cross-Over Studies; D005079:Excipients / Q000737:chemistry; D005780:Gelatin; D008297:Male; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D011817:Rabbits; D013237:Stereoisomerism; D014810:Vitamin E / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics*; D014815:Vitamins / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D024502:alpha-Tocopherol / Q000097:blood
D002214:Capsules; D005079:Excipients; D011135:Polysaccharides, Bacterial; D014815:Vitamins; D014810:Vitamin E; D005780:Gelatin; D000688:Amylose; D024502:alpha-Tocopherol