Assessment of intramolecular contact predictions for CASP7.
Predictions of intramolecular residue-residue contacts were assessed as part of the seventh community-wide Critical Assessment of Structure Prediction experiment (CASP7). As in past assessments, we focused on contacts that lie far apart in sequence as these are likely to be more informative in predicting protein structure. One lab did somewhat better than others according to our assessment, and there is some reason to think that this lab's results represent progress over CASP6. In general, contacts inferred from 3D structural predictions are similar in accuracy to those predicted by contact prediction methods. However, contact prediction methods were more accurate for some targets.
Izarzugaza
José M G
JM
Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre, 3E-28029 Madrid, Spain.
Graña
Osvaldo
O
Tress
Michael L
ML
Valencia
Alfonso
A
Clarke
Neil D
ND
D000465:Algorithms; D001665:Binding Sites; D019295:Computational Biology / Q000379:methods*; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry
D011506:Proteins