[The prevalence and risk factors of invasive fungal infection in hematopoietic stem cell transplant recipients].
OBJECTIVE
To study the incidence and risk factors of invasive fungal infection (IFI) in allogeneic hematopoietic stem cell transplant (HSCT) recipients.


METHODS
One hundred and forty-eight patients, undergoing formed HSCT at this institute from June 2003 to September 2004, were analyzed retrospectively according to the diagnostic criteria of IFI.


RESULTS
Fifty-two cases of IFI were diagnosed, with 35 proven and 17 probable. The infection occurred a median of 62 days after HSCT and the cumulative incidence of proven IFI in 3 months, 6 months and one year after HSCT were 15.6%, 42.5% and 48.9% respectively. By multivariate analysis, the variable associated with early infection risk were severe acute graft-versus-host disease (GVHD), prolonged administration of broad spectrum antibiotics and cytomegalovirus infection, while chronic extensive GVHD and glucocorticosteroid use were associated with the late-onset IFI.


CONCLUSIONS
Patients undergoing HSCT and having many risk factors are more likely predisposed to IFI, avoiding the risk factors might could reduce the incidence rate of IFI.
Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China.
Lan-Ping
LP
Xu
Yu
Y
Ji
Dai-Hong
DH
Liu
Yu-Hong
YH
Chen
Wei
W
Han
Kai-Yan
KY
Liu
Xiao-Jun
XJ
Huang
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors