Evolutionary conservation of alternative splicing in chicken.
Alternative splicing represents a source of great diversity for regulating protein expression and function. It has been estimated that one-third to two-thirds of mammalian genes are alternatively spliced. With the sequencing of the chicken genome and analysis of transcripts expressed in chicken tissues, we are now in a position to address evolutionary conservation of alternative splicing events in chicken and mammals. Here, we compare chicken and mammalian transcript sequences of 41 alternatively-spliced genes and 50 frequently accessed genes. Our results support a high frequency of splicing events in chicken, similar to that observed in mammals.
Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada.
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Katyal
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Gao
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Liu
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Godbout
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002645:Chickens / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics; D009928:Organ Specificity; D012160:Retina / Q000378:metabolism
D009419:Nerve Tissue Proteins