Leydig cell tumor and hyperplasia: a review.
We describe the role of Leydig cells in normal, hyperplastic and neoplastic testis. Recent acquisitions on etiology and pathobiology of Leydig cell proliferations, unusual microscopic presentations and clinical and morphologic features predictive of malignancy are reported.
Colecchia
Maurizio
M
Department of Pathology, National Cancer Institute Foundation, Milan, Italy. maurizio.colecchia@istitutotumori.milano.it
Nistal
Manuel
M
Gonzalez-Peramato
Pilar
P
Carmignani
Luca
L
Salvioni
Roberto
R
Nicolai
Nicola
N
Regadera
Javier
J
D002454:Cell Differentiation; D006801:Humans; D006965:Hyperplasia; D007984:Leydig Cell Tumor / Q000473:pathology* / Q000648:ultrastructure; D007985:Leydig Cells / Q000473:pathology; D008297:Male; D013736:Testicular Neoplasms / Q000473:pathology*; D013737:Testis / Q000166:cytology / Q000196:embryology