Loop-closure principles in protein folding.
Simple theoretical concepts and models have been helpful to understand the folding rates and routes of single-domain proteins. As reviewed in this article, a physical principle that appears to underly these models is loop closure.
Weikl
Thomas R
TR
Max Planck Institute of Colloids and Interfaces, Department of Theory and Bio-Systems, 14424 Potsdam, Germany. weikl@mpikg.mpg.de
D007700:Kinetics; D017510:Protein Folding; D013816:Thermodynamics