[Myeloma, Kaposi's sarcoma and HHV8 infection in hemodialyzed patient].
BACKGROUND
The association between Kaposi's sarcoma, Human Herpes Virus 8 infection and multiple myeloma is still controversial especially in hemodialysed patient.


OBJECTIVE
report a new case of this association.


METHODS
We report the case of a 83 year old man in whom the diagnosis of multiple myeloma of IgA/kappa had been made in December 2003 with end stage renal failure requiring hemodialysis. Initially, it had been treated with Melphalan, Cyclophosphamide, Prednisolone and Vincristine and secondary by Melphalan and Prednisone. Three months later, he had developed extensive porpour lesions in his lower limbs. Skin biopsy had been informed of Kaposi's sarcoma. Human Herpes Virus 8 test was positive.


CONCLUSIONS
Our observation is another case supporting the hypothesis that Kaposi's sarcoma and multiple myeloma share a common aetiology such as Human Herpes Virus 8. The immunodepressed state related to aging, multiple myeloma, chemotherapy and hemodialysis was the probable factor responsible of rapidly progressive Kaposi's sarcoma in our patient. The association myeloma and Human Herpes Virus 8 infection is still controversial.
Bacha
Mohamed Mongi
MM
Service de Médecine Interne A, Hôpital Charles Nicolle, Tunis, Tunisie.
Goucha
Rym
R
Zouaghi
Karim
K
Jebali
Hela
H
Fazaa
Bassima
B
Hedri
Hafedh
H
El Younsi
Fethi
F
Abderrahim
Ezzeddine
E
Ben Hamida
Fethi
F
Ben Abdallah
Taïeb
T
Ben Moussa
Fatma
F
Kammoun
Riadh
R
Ben Maiz
Hedi
H
Kheder
Adel
A
D000369:Aged, 80 and over; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D009101:Multiple Myeloma / Q000150:complications*; D006435:Renal Dialysis; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000821:virology; D012878:Skin Neoplasms / Q000150:complications* / Q000821:virology