[Effect of lifestyle adjustment, metformin and rosiglitazone in polycystic ovary syndrome].
OBJECTIVE
To compare the efficacy of weight loss, metformin and rosiglitazone in women with polycystic ovary syndrome (PCOS).


METHODS
A randomized controlled trial (RCT) was carried out in Peking Union Medical College Hospital (PUMCH), one hundred and six women with PCOS were assigned to three intervention groups: weight loss, weight loss and metformin, weight loss and rosiglitazone group. Patients were treated with weight loss (diet and exercise), weight loss and metformin (500 mg three times daily), weight loss and rosiglitazone (4 mg once daily) for three months. Sixty patients completed treatments. Basal body temperature (BBT), total testosterone as well as fasting serum insulin levels and lipid were measured and compared in all patients before and after weight loss.


RESULTS
No significant differences were found in the baseline characteristics among three groups. In weight loss group 51% (22/43) patients completed treatment, and 23% (5/22) patients resumed ovulation. In weight loss and metformin group 58% (21/36) patients completed treatment, and 43% (9/21) patients resumed ovulation. In weight loss and rosiglitazone group 63% (17/27) patients completed treatment, and 59% (10/17) patients resumed ovulation. Ovulation rate was significantly higher in weight loss and rosiglitazone group than in weight loss group. There was no significant difference among three groups in body mass index (BMI), waist circumference, waist-hip ratio (WHR), sex hormone, serum fasting insulin and lipid level after treatment.


CONCLUSIONS
Weight loss, metformin and rosiglitazone all can improve ovulation each.
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Liang-Kun
LK
Ma
Li-Na
LN
Jin
Qi
Q
Yu
Ling
L
Xu
D000328:Adult; D015992:Body Mass Index; D004359:Drug Therapy, Combination; D015444:Exercise; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008019:Life Style; D008055:Lipids / Q000097:blood; D008687:Metformin / Q000008:administration & dosage / Q000627:therapeutic use*; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*; D013739:Testosterone / Q000097:blood; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D007328:Insulin; D008055:Lipids; D045162:Thiazolidinediones; D013739:Testosterone; D008687:Metformin