Idiopathic purpura fulminans in dengue hemorrhagic fever.
Purpura fulminans is a rapidly progressive thrombotic disease that has been described during both severe bacterial and viral infections. Disseminated intravascular coagulation (DIC), antiphospholipid antibodies and acquired or congenital C and S protein deficiency are thought to play a role in its pathogenesis. Here we report the case of a 4-year-old girl who developed gangrene of all her fingers and toes following dengue shock syndrome complicated by DIC and also discuss its management.
Lady Ridgeway Hospital for Children, Colombo 8, Sri Lanka. dhkaru@sltnet.lk
D H
DH
Karunatilaka
J R S
JR
De Silva
P K
PK
Ranatunga
T Mr
TM
Gunasekara
M Am
MA
Faizal
G N
GN
Malavige
D002675:Child, Preschool; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005734:Gangrene / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D019595:Severe Dengue / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology