In vivo toxic studies and biodistribution of near infrared sensitive Au-Au(2)S nanoparticles as potential drug delivery carriers.
Near infrared (NIR) sensitive Au-Au(2)S nanoparticles are intensively being developed for biomedical applications including drug and gene delivery. Although all possible clinical applications will require compatibility of Au-Au(2)S nanoparticles with the biological milieu, their in vivo capabilities and limitations have not yet been explored. Au-Au(2)S nanoparticles and cisplatin-loaded Au-Au(2)S nanoparticles were successfully synthesized by the reduction of tetrachloroauric acid (HAuCl(4)) using sodium sulfide (Na(2)S), and cisplatin was loaded onto NIR sensitive Au-Au(2)S nanoparticles via an MUA (11-mercaptoundecanoic acid) layer. In this work, acute systemic toxicity in vivo, blood biochemistry assay, and tissue distribution in mice were carried out to further investigate the biocompatibility and biodistribution of these nanoparticles. The results from these studies demonstrated that both of nanoparticles (<200 microg/mL) might have a great advantage in biocompatibility and good biological safety.
Research Center of Biomedical Engineering, Xiamen University, P.R. China.
Xiao-Li
XL
Huang
Bin
B
Zhang
Lei
L
Ren
She-Fang
SF
Ye
Li-Ping
LP
Sun
Qi-Qing
QQ
Zhang
Mei-Chee
MC
Tan
Gan-Moog
GM
Chow
D000818:Animals; D004337:Drug Carriers / Q000493:pharmacokinetics* / Q000633:toxicity*; D006046:Gold / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D053758:Nanoparticles / Q000633:toxicity*; D009928:Organ Specificity; D013455:Sulfur / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity*; D014018:Tissue Distribution
D004337:Drug Carriers; D013455:Sulfur; D006046:Gold