Whole- and refined-grain intakes and the risk of hypertension in women.
BACKGROUND
Prospective studies linking whole- and refined-grain intakes with the risk of hypertension, a major cardiovascular disease risk factor, remain limited.


OBJECTIVE
We aimed to determine whether baseline intake of whole or refined grains is associated with subsequent development of hypertension.


METHODS
We conducted a prospective cohort study in 28 926 female US health professionals aged >or=45 y who were free of baseline cardiovascular disease, cancer, and hypertension in 1992. Baseline whole- and refined-grain intakes were assessed from semiquantitative food-frequency questionnaires. We identified 8722 incident cases of hypertension from annual questionnaires during 10 y of follow-up.


RESULTS
After adjustment for known hypertension risk factors, the relative risks (RRs) (and 95% CIs) of incident hypertension were 1.00 (reference), 0.96 (0.89, 1.03), 0.95 (0.88, 1.02), 0.92 (0.85, 0.99), and 0.89 (0.82, 0.97) across the increasing quintiles of baseline whole-grain intake (P for trend = 0.007). When functional cutoffs were used, women who consumed 0.5 to <1, 1 to <2, 2 to <4, and >or=4 whole-grain servings/d had multivariate RRs (95% CIs) of 0.93 (0.87, 1.00), 0.93 (0.87, 0.99), 0.92 (0.85, 0.99), and 0.77 (0.66, 0.89), respectively, compared with those who consumed <0.5 whole-grain servings/d. In contrast, refined-grain intake was not associated with the risk of hypertension. The multivariate RRs of hypertension across the increasing quintiles of refined-grain intake were 1.00, 0.97, 0.94, 0.99, and 0.97 (P for trend = 0.80).


CONCLUSIONS
Higher whole-grain intake was associated with a reduced risk of hypertension in middle-aged and older women, which suggests a potential role for increasing whole-grain intake in the primary prevention of hypertension and its cardiovascular complications.
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. luwang@rics.bwh.harvard.edu
Lu
L
Wang
J Michael
JM
Gaziano
Simin
S
Liu
JoAnn E
JE
Manson
Julie E
JE
Buring
Howard D
HD
Sesso
D000368:Aged; D001794:Blood Pressure; D004032:Diet; D004311:Double-Blind Method; D002523:Edible Grain; D015444:Exercise; D005260:Female; D005511:Food Handling; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008875:Middle Aged; D009752:Nutritional Status; D010919:Placebos; D012307:Risk Factors; D011795:Surveys and Questionnaires
D010919:Placebos