Methaemoglobinaemia causing progressive dyspnoea and cyanosis during treatment of Pneumocystis jirovecii pneumonia.
An HIV-infected man became increasingly breathless and cyanosed while receiving clindamycin and primaquine treatment for Pneumocystis jirovecii pneumonia. He was found to have 11.4% methaemoglobinaemia and recovered with conservative management.
Department of Genito-urinary Medicine, Mortimer Market Centre, Camden Primary Care Trust, London, UK.
Matthew
M
Hamill
Derval
D
Harte
Robert F
RF
Miller
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D003490:Cyanosis / Q000209:etiology; D004417:Dyspnea / Q000209:etiology; D006801:Humans; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced / Q000150:complications*; D045363:Pneumocystis carinii / Q000472:pathogenicity; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D011319:Primaquine / Q000009:adverse effects* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D011319:Primaquine