[Marine microbial metagenomics: progress and prospect].
Preliminary statistics showed that there are more than one million species of microbes in marine environments that formed a dynamic genetic reservoir, among which the majority are not revealed and categorized due to barrier in cultivation techniques. However, the situation has changed in recent years because of the rapid development of phylogenetic studies based on small ribosomal RNA and rDNA sequencing independent to standard laboratory cultivation. These changes have significantly altered our understanding about microbial diversity and microbial ecology. In this review, we highlight some of recent progress and innovation in research on microbial diversity, and propose a metagenomic scheme as an alternative to overcome some of the barriers that still remain for exploitation of marine microbial diversity for its enormous potential in pharmaceutical applications. We believe that rapid progress in marine metagenomics allows direct access to the genomes of numerous non-cultivable microorganisms for their associated chemical prosperity.
Li
Xiang
X
Guangdong Key Lab of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. lixiang@scsio.ac.cn
Qin
Ling
L
Dai
Shi-kun
SK
Jiang
Shu-mei
SM
Liu
Zhi-heng
ZH
D001419:Bacteria / Q000235:genetics* / Q000302:isolation & purification; D044822:Biodiversity; D003001:Cloning, Molecular; D016680:Genome, Bacterial; D012623:Seawater / Q000382:microbiology*