Dicaprylyl maleate--an emerging cosmetic allergen.
Dicaprylyl maleate (DCM) has been reported rarely as a cause of allergic contact dermatitis. The objectives of this study were to identify patients from multiple centres with allergy to DCM in cosmetic products confirmed by patch testing and, in addition, to investigate the effect of testing with aged DCM. This is an international multicentre study of 22 patients with 26 reactions to products containing DCM. Patch testing was carried out to ingredients including DCM obtained from the manufacturer. Further testing was carried out with deliberately aged DCM in a sample of patients. 22 patients had clinical and positive patch test reactions at 4 days to a total of 26 cosmetic products containing DCM. 5 patients did not react to DCM prepared by the manufacturer from concurrent factory stock but did have positive reactions to a deliberately aged batch of DCM. DCM is an emerging cosmetic allergen. Testing with aged material yields a greater number of positive results. Co-operation between cosmetics manufacturers and clinicians is important in the identification of new allergens.
Lotery
Helen
H
Department of Dermatology, Southampton University Hospitals Trust, Southampton, UK. hlotery@doctors.org.uk
Kirk
Stephen
S
Beck
Michael
M
Burova
Ekaterina
E
Crone
Mary
M
Curley
Reginald
R
Downs
Anthony
A
Hill
Glenda
G
Horne
Helen
H
Iftikhar
Nadia
N
Lovell
Christopher
C
Malanin
Ken
K
Orton
David
D
Powell
Sheila
S
Sansom
Jane
J
Sonnex
Timothy
T
Todd
David
D
Tucker
Simon
S
Wilkinson
Mark
M
Haworth
Adam
A
D000328:Adult; D000368:Aged; D000485:Allergens / Q000009:adverse effects*; D003358:Cosmetics / Q000009:adverse effects* / Q000737:chemistry; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D004643:Emollients / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008298:Maleates / Q000009:adverse effects* / Q000737:chemistry; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods
D000485:Allergens; D003358:Cosmetics; D004643:Emollients; D008298:Maleates; C484947:dioctyl maleate