Cassiarins A and B, novel antiplasmodial alkaloids from Cassia siamea.
Two novel alkaloids with an unprecedented tricyclic skeleton, cassiarins A (1) and B (2), have been isolated from the leaves of Cassia siamea, and the structures were elucidated on the basis of spectroscopic data. Cassiarin A (1) showed a potent antiplasmodial activity.
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan. moritah@hoshi.ac.jp
Hiroshi
H
Morita
Shiori
S
Oshimi
Yusuke
Y
Hirasawa
Koichiro
K
Koyama
Toshio
T
Honda
Wiwied
W
Ekasari
Gunawan
G
Indrayanto
Noor Cholies
NC
Zaini
D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000627:therapeutic use; D002366:Cassia / Q000737:chemistry*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D006575:Heterocyclic Compounds, 3-Ring; D010936:Plant Extracts; C524027:cassiarin A; C524026:cassiarin B