Crystal structure based design of functional metal/protein hybrids.
Preparation of metal/protein hybrids is growing into important topics in the field of bioinorganic chemistry. X-ray crystal structure analyses of them provide direct information on unique interactions of metal cations or metal cofactors to understand and design enzymatic functions. In this mini review, the authors focus on the recent studies on the metal/protein hybrids concerning crystal structure analyses since 2002 and our related works. The precise structural determination promise us to deeply understand coordination chemistry in protein scaffold and shows intriguing suggestions on rational design and application use for biocatalysts, metal drugs and so on.
Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
Takafumi
T
Ueno
Norihiko
N
Yokoi
Satoshi
S
Abe
Yoshihito
Y
Watanabe
D001665:Binding Sites; D008667:Metalloproteins / Q000737:chemistry / Q000378:metabolism; D008670:Metals / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
D008667:Metalloproteins; D008670:Metals; D011506:Proteins