Are neuropsychological changes relevant in subclinical hypothyroidism?
BACKGROUND
Neuropsychological changes are still controversial in patients with subclinical hypothyroidism (SH). The objective of this study is to assess these changes.


METHODS
Cross-sectional study comparing the results of the neurocognitive evaluation of 65 SH patients and 31 individuals without thyroid disease. Subclinical hypothyroidism was defined as at least two elevated serum TSH levels (> 4 microUI/ml) with normal serum free T4 levels (0.9-1.8 ng/dl). The participants underwent the following neuropsychological assessment: Buschkes Selective Reminding Procedure, Rey-Osterrieth Complex Figure Test, Warrington's Recognition Memory Test for Words and Faces, and the Vocabulary subtest of the WAIS-R.


RESULTS
The groups were similar in regard to mean age, sex and educational level. No neuropsychological change was found in patients with SH when compared with euthyroid individuals.


CONCLUSIONS
No difference was observed in the performance of the neuropsychological tests between both groups in regard to the functions studied.
Endocrinology Service, HUCFF, UFRJ, Av. Brigadeiro Trompowski s/n, 21941-590 Rio de Janeiro, RJ. mleite@openlink.com.br
Cloyra
C
Almeida
Mario
M
Vaisman
Antonio José Leal
AJ
Costa
Fabiola A A
FA
Reis
Vaneska
V
Reuters
Patricia
P
Teixeira
Marcia
M
Ferreira
Letícia B B de M
LB
Teixeira
Glória R B de
GR
Araújo
Marco Antonio
MA
Brasil
D000328:Adult; D003071:Cognition; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis / Q000523:psychology*; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis*; D008875:Middle Aged; D009483:Neuropsychological Tests; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014888:Wechsler Scales
D013972:Thyrotropin; D013974:Thyroxine