TIM-3 as a therapeutic target in human inflammatory diseases.
T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) was the first, and is presently the only, surface molecule that can specifically identify T(H)1 cells in both mice and humans. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear.
Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, MA 02115, Boston, USA. danderson@rics.bwh.harvard.edu
David E
DE
Anderson
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D016503:Drug Delivery Systems / Q000379:methods*; D000072597:Hepatitis A Virus Cellular Receptor 2; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism* / Q000502:physiology; D008565:Membrane Proteins; D011991:Receptors, Virus / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology
C448908:HAVCR2 protein, human; D000072597:Hepatitis A Virus Cellular Receptor 2; D018836:Inflammation Mediators; D008565:Membrane Proteins; D011991:Receptors, Virus