Deceased donors with a past history of malignancy: an organ procurement and transplantation network/united network for organ sharing update.
Approximately 2% of deceased donor organ transplants result from donors with a past history of cancer. An analysis of Organ Procurement and Transplantation Network/United Network for Organ Sharing data on 39,455 deceased donors from 2000 to 2005 showed 1069 donors had a PHC, resulting in 2508 transplants, including 1236 kidneys, 891 livers, 199 hearts, 100 lungs, and 82 miscellaneous organs. The most common type of previous cancer in the donor was nonmelanoma skin cancer (n=776) followed by central nervous system malignancies (n=642) and carcinoma of the uterine cervix (n=336). One donor with a glioblastoma multiforme transmitted fatal tumors to three recipients. One donor with a history of melanoma 32 years earlier transmitted a fatal melanoma to a single recipient and, therefore, donors with a history of melanoma should not be used. Donors with a past history of cancer who have a nontraumatic cerebral hemorrhage cause concern because this hemorrhage may be the result of an unrecognized metastatic tumor.
Kauffman
H Myron
HM
Research Department, United Network for Organ Sharing, Richmond, VA 23219, USA. kauffmhm@unos.org
Cherikh
Wida S
WS
McBride
Maureen A
MA
Cheng
Yulin
Y
Hanto
Douglas W
DW
D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000453:epidemiology*; D016377:Organ Transplantation / Q000009:adverse effects*; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D014019:Tissue Donors; D009927:Tissue and Organ Procurement; D014481:United States / Q000453:epidemiology