Anti-oxidant constituents from Sedum takesimense.
As part of an ongoing search for antioxidants from medicinal plants, 14 phenolic constitutents were isolated from the Korean endemic species Sedum takesimense Nakai. Their structures were determined as 1-(4-hydroxyphenyl)-2-(3,5-dihydroxyphenyl)-2-hydroxyethanone (5), gossypetin-8-O-beta-d-xylopyranoside (10), and 2,6-di-O-galloylarbutin (13) on the basis of spectroscopic analyses (IR, UV, 1D and 2D NMR, HR-MS) and chemical degradation, together with 11 previously known phenolics. Two of those (10 and 13) exhibited strong scavenging activities against DPPH and superoxide radicals as well as significant inhibitory effects on lipid peroxidation (IC(50) 14.0 and 10.8 microM, respectively) and LDL oxidation induced by a metal ion Cu(2+) (IC(50) 5.7 and 3.3 microM, respectively).
Thuong
Phuong Thien
PT
College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
Kang
Ho Jeong
HJ
Na
MinKyun
M
Jin
WenYi
W
Youn
Ui Jung
UJ
Seong
Yeon Hee
YH
Song
Kyung-Sik
KS
Min
Byung-Sun
BS
Bae
KiHwan
K
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D015394:Molecular Structure; D031963:Sedum / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods
D000975:Antioxidants; D016166:Free Radical Scavengers