[Expression and clinical significance of Survivin and Livin in DukesoB colorectal cancer].
OBJECTIVE
Survivin and Livin, members of the family of inhibitor of apoptosis proteins (IAPs), are specially expressed in embryonic cells and tumor cells, but are seldom expressed in normal adult cells. Some studies showed that they are correlated to poor prognosis of some tumors. This study was to detect the expression of Survivin and Livin in DukesoB colorectal cancer, and analyze the clinical significance.


METHODS
The expression of Survivin and Livin in 81 specimens of DukesoB colorectal cancer and 12 specimens of normal colorectal tissues was detected by SP immunohistochemistry. Their correlations to clinical features and survival were analyzed.


RESULTS
The positive rates of Survivin and Livin were significantly higher in colorectal cancer than in normal colorectal tissues (58.0% vs. 16.7%, 45.7% vs. 8.3%,P < 0.05). No relationship was found between the expression of Survivin and Livin(P > 0.05). The expression of Survivin and Livin was not correlated to sex, tumor location, primary size, T stage, pathologic category, and degree of differentiation(P> 0.05). The positive rate of Survivin was significantly higher in the patients older than 50 years than in the patients younger than 50 years (70.6% vs. 36.7%, P < 0.05). Both Survivin and Livin were correlated to tumor recurrence and/or metastasis (P = 0.02, P = 0.001), and shorter survival (P = 0.039, P = 0.001). Cox multivariate analysis showed stage T4 and positive Livin expression were independent prognostic factors of DukesoB colorectal cancer (P = 0.002, P = 0.047).


CONCLUSIONS
Survivin and Livin are overexpressed in DukesoB colorectal cancer. Livin is closely related to recurrence and/or metastasis and poor prognosis of DukesoB colorectal cancer after curative resection.
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China.
Jun-He
JH
Li
Wen-Jing
WJ
He
You-Jian
YJ
He
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012004:Rectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D015996:Survival Rate; D000077022:Survivin; D055815:Young Adult
D048868:Adaptor Proteins, Signal Transducing; C107489:BIRC5 protein, human; C419866:BIRC7 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin