Effects of dietary intervention on weight loss and improvement of metabolic cormorbidities in a population of obese adults.
BACKGROUND
Weight loss improves most of the comorbidities associated with obesity.


OBJECTIVE
The purposes of this study are to determine the effects of dietary intervention and physical activity on weight management and to evaluate the beneficial effects of weight loss on metabolic profile of obese adults.


METHODS
This prospective study concerned 24 obese and overweight patients recruited between 2003-2004. They have undergone a 6 months period of personalized diet and physical exercise.


RESULTS
Average weight loss achieved at 6 months was 6.8 +/- 5.6 kg (P < 10). Mean fat mass reduction was 3.05 +/- 6.2% (P = 0.02) and average waist circumference reduction was 7.55 +/- 5.21 cm (P < 10(-3)). This improvement in anthropometric parameters reduced significantly fasting glycaemia (-0.58 +/- 0.87 mmol/l, P = 0.01), total cholesterol levels (- 0.37 +/- 0.69 mmol/l, P = 0.03), triglyceridemia (- 0.39 +/- 0.45 mmol/ l, P = 0.004) and increased HDL-Cholesterol levels (+ 0.1 +/- 0.38 mmol/l, P = 0.05).


CONCLUSIONS
These results emphasize the urgent need to develop national strategies for the prevention and the management of overweight and obesity. Hence, we can improve metabolic abnormalities usually associated with obesity and reduce cardiovascular risk factors.
Unit of obesity, Tunisian National Institute of Nutrition.
Chiraz
C
Rached-Amrouche
Henda
H
Jamoussi-Kammoun
Samira
S
BLouza-Chabchoub
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D004032:Diet; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000628:therapy*; D011446:Prospective Studies; D015431:Weight Loss
D001786:Blood Glucose; D002784:Cholesterol