Therapeutic and clinical applications of nitroxide compounds.
Nitroxide compounds have been used for many years as biophysical tools, but only during the past 15-20 years have the many interesting biochemical interactions been discovered and harnessed for therapeutic applications. By modifying oxidative stress and altering the redox status of tissues, nitroxides have the ability to interact with and alter many metabolic processes. This interaction can be exploited for therapeutic and research use, including protection against ionizing radiation, as probes in functional magnetic resonance imaging, cancer prevention and treatment, control of hypertension and weight, and protection from damage resulting from ischemia/reperfusion injury. Although much remains to be done, many applications have been well studied, and some are presently being tested in clinical trials. The therapeutic and research uses of nitroxides are reviewed here, with a focus on the progress from initial development to modern, state-of-the art trials.
Soule
Benjamin P
BP
Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. souleb@mail.nih.gov
Hyodo
Fuminori
F
Matsumoto
Ken-Ichiro
K
Simone
Nicole L
NL
Cook
John A
JA
Krishna
Murali C
MC
Mitchell
James B
JB
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009589:Nitrogen Oxides / Q000627:therapeutic use*; D010084:Oxidation-Reduction; D011837:Radiation-Protective Agents / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D009589:Nitrogen Oxides; D011837:Radiation-Protective Agents; C039900:nitroxyl