[Increased dietary intake of omega-3-PUFA reduces pathological retinal angiogenesis].
According to a recent publication in Nature Medicine an increased dietary intake of omega-3-polyunsaturated fatty acids (PUFA) may protect against the development and progression of retinal neovascularization. The study conducted by L. Smith et al. of the Children's Hospital Boston attracts world-wide attention. In a mouse model of oxygen-induced retinopathy the researchers were able to demonstrate that neonatal mice kept on a "Japanese diet" (i.e. rich in omega-3-PUFA) developed about 50% less retinal neovascularization as compared to mice kept on a "Western diet" (rich in omega-6-PUFA). The results are now being followed-up by a clinical study with the aim to investigate whether prematurely born infants with a high risk of developing ROP may benefit from a diet supplemented with omega-3-PUFA. In addition, the AREDS2-Study which commenced in October 2006 is examining the role of omega-3-PUFA in the development and progression of age-related macular degeneration.
Universitäts-Augenklinik, Ernst-Abbe-Strasse 2, 53127, Bonn, Deutschland. Suzan.Hunt@ukb.uni-bonn.de
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D000818:Animals; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D012164:Retinal Diseases / Q000517:prevention & control*; D012171:Retinal Vessels / Q000187:drug effects*
D004041:Dietary Fats; D015525:Fatty Acids, Omega-3