[Bone marrow cell transplantation combined with transmyocardial revascularization and off-pump coronary bypass grafting: three-in-one surgery on ischemic heart].
A 61-year-old male patient, with the history of premier myocardial infarction and CABG surgery, experienced recurrent unstable angina. Angiography showed triple vessel disease and vein grafts obstruction. The patient underwent a re-do OPCAB + TMLR + bone marrow mononuclear cell (BM-MNCs) transplantation on Nov. 8, 2004. BM-MNCs were isolated with standard gravity gradient method and the final implanted cell number was 12.06 x 10(8). Peri-operative data were similar to those of single OPCAB or re-CABG. The patient recovered promptly without recurrence of angina or infarction. Six-minute walking distance increased significantly (366m to 493m). Several imaging examinations reveal improved left cardiac function (LVEF improved from 23.75% to 52% in MRI) and diminished MI area. The results reveal that bone marrow cell transplantation, combined with TMLR and OPCAB is safe and might be effective in improving heart function for patients with IHD.
Zhao
Hong
H
Department of Cardiac Surgery, Peking university People's Hospital, Beijing 100044, China.
Wan
Feng
F
D016026:Bone Marrow Transplantation; D047549:Coronary Artery Bypass, Off-Pump; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000601:surgery*; D057769:Transmyocardial Laser Revascularization; D016896:Treatment Outcome