IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex.
IL-33 (IL-1F11) is a recently described member of the IL-1 family of cytokines that stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune response. IL-33 mediates signal transduction through ST2, a receptor expressed on Th2 and mast cells. In this study, we demonstrate that IL-33 and ST2 form a complex with IL-1R accessory protein (IL-1RAcP), a signaling receptor subunit that is also a member of the IL-1R complex. Additionally, IL-1RAcP is required for IL-33-induced in vivo effects, and IL-33-mediated signal transduction can be inhibited by dominant-negative IL-1RAcP. The implications of this shared usage of IL-1RAcP by IL-1(alpha and beta) and IL-33 are discussed.
Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, CA 94304, USA.
Alissa A
AA
Chackerian
Elizabeth R
ER
Oldham
Erin E
EE
Murphy
Jochen
J
Schmitz
Stefan
S
Pflanz
Robert A
RA
Kastelein
D000818:Animals; D005786:Gene Expression Regulation / Q000276:immunology; D005799:Genes, Dominant / Q000276:immunology; D053577:Interleukin-1 Receptor Accessory Protein / Q000172:deficiency / Q000276:immunology*; D000072179:Interleukin-1 Receptor-Like 1 Protein; D053582:Interleukin-1alpha / Q000235:genetics / Q000276:immunology; D053583:Interleukin-1beta / Q000235:genetics / Q000276:immunology; D000067596:Interleukin-33; D007378:Interleukins / Q000235:genetics / Q000276:immunology*; D008407:Mast Cells / Q000166:cytology / Q000276:immunology*; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D046912:Multiprotein Complexes / Q000235:genetics / Q000276:immunology*; D021122:Protein Subunits / Q000235:genetics / Q000276:immunology; D018123:Receptors, Interleukin; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D018418:Th2 Cells / Q000166:cytology / Q000276:immunology*
C507767:Il1rap protein, mouse; C486189:Il1rl1 protein, mouse; C506535:Il33 protein, mouse; D053577:Interleukin-1 Receptor Accessory Protein; D000072179:Interleukin-1 Receptor-Like 1 Protein; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D000067596:Interleukin-33; D007378:Interleukins; D008565:Membrane Proteins; D046912:Multiprotein Complexes; D021122:Protein Subunits; D018123:Receptors, Interleukin