Relationship between hyperuricemia and metabolic syndrome.
OBJECTIVE
To investigate the relationship between metabolic syndrome and hyperuricemia.


METHODS
A total of 2 374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our study. Hyperuricemia is defined as >or=7 mg/dl (in men) or >or=6.0 mg/dl (in women). Metabolic syndrome was defined using AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria.


RESULTS
(1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%). (2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased risk of metabolic syndrome as compared with those without hyperuricemia [odds ratio (OR)=1.634, P=0.000]. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia.


CONCLUSIONS
Hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic syndrome.
Chen
Li-ying
LY
Department of Family Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. cly0906@163.com
Zhu
Wen-hua
WH
Chen
Zhou-wen
ZW
Dai
Hong-lei
HL
Ren
Jing-jing
JJ
Chen
Jian-hua
JH
Chen
Lei-qian
LQ
Fang
Li-zheng
LZ
D000328:Adult; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000453:epidemiology / Q000652:urine*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology / Q000652:urine*; D012307:Risk Factors; D012727:Sex Characteristics; D014527:Uric Acid / Q000652:urine
D014527:Uric Acid