[Pathologic condition of osteoporosis in rheumatoid arthritis].
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic synovitis which causes osteoporosis and joint destruction. Recently, it has been well understood that pro-inflammatory cytokine plays a pivotal role in disease progression. These pro-inflammatory cytokine induces activation of osteoclasts, resulting in paraarticular osteoporosis and joint destruction. While systemic osteoporosis caused by several factors is often seen in patients with RA. This article reviews the pathologic condition of osteoporosis in RA.
Suwa
Akira
A
Tokai University School of Medicine, Department of Internal Medicine, Division of Rheumatology, Japan.
Saito
Eiko
E
Wakabayashi
Takayuki
T
Suzuki
Yasuo
Y
D001172:Arthritis, Rheumatoid / Q000150:complications*; D016723:Bone Remodeling; D001862:Bone Resorption; D002454:Cell Differentiation; D016572:Cyclosporine / Q000009:adverse effects; D018450:Disease Progression; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D008593:Menopause; D008727:Methotrexate / Q000009:adverse effects; D010010:Osteoclasts / Q000166:cytology; D010024:Osteoporosis / Q000209:etiology*; D053245:RANK Ligand / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D005938:Glucocorticoids; D053245:RANK Ligand; C505688:TNFSF11 protein, human; D014409:Tumor Necrosis Factor-alpha; D016572:Cyclosporine; D008727:Methotrexate