Synthesis of degradable functional poly(ethylene glycol) analogs as versatile drug delivery carriers.
Poly(ethylene glycol) (PEG) is widely used as a water soluble carrier for polymer-drug conjugates. Herein, we report degradable linear PEG analogs (DPEGs) carrying multifunctional groups. The DPEGs were synthesized by a Michael addition based condensation polymerization of dithiols and PEG diacrylates (PEGDA) or dimethacrylates (PEGDMA). They were stable at pH 7.4 but quickly degraded at pH 6.0 and 5.0. Thus, DPEGs could be used as drug carriers without concern for their retention in the body. DPEGs could be made to carry such functional groups as terminal thiol or (meth)acrylate and pendant hydroxyl groups. The functional groups were used for conjugation of drugs and targeting groups. This new type of PEG analog will be useful for drug delivery and the PEGylation of biomolecules and colloidal particles.
Wang
Na
N
Soft Materials Laboratory and Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, Wyoming, 82071, USA.
Dong
Anjie
A
Tang
Huadong
H
Van Kirk
Edward A
EA
Johnson
Patrick A
PA
Murdoch
William J
WJ
Radosz
Maciej
M
Shen
Youqing
Y
D001673:Biodegradation, Environmental; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D013696:Temperature
D011092:Polyethylene Glycols