[Increase in T-cell level in the peripheral blood of women with fractures in anamnesis during postmenopause period].
44 postmenopausal patients (45-76 years of old) have been observed. Interrelationship between composition and functional activity of peripheral blood cells, TNF-alpha level in the serum and bone density in postmenopausal women has been analyzed. It was established that the increase in neutrophil activity in women with osteoporosis, the high level of immune complexes are accompanied by the high level of IgG and autoantibodies to DNA. These results allow suggesting the presence of chronic inflammatory or immune processes taken place in postmenopausal women with osteoporosis. Increase in CD3+ cells percent was established in women with fracture in anamnesis. Obtained results allow suggesting the possibility that T-cells may play a role in the occurrence of fractures.
Pishel'
I M
IM
Hryhor'ieva
N V
NV
Rodnichenko
A Ie
AIe
Pashynian
L N
LN
Mahdych
L V
LV
Povorozniuk
V V
VV
Butenko
H M
HM
D000368:Aged; D015519:Bone Density / Q000276:immunology; D017252:CD3 Complex / Q000276:immunology; D005260:Female; D050723:Fractures, Bone / Q000097:blood / Q000276:immunology*; D006801:Humans; D018655:Lymphocyte Count; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D017252:CD3 Complex; D014409:Tumor Necrosis Factor-alpha