Pregnancy after tumor debulking and intraperitoneal cisplatin for appendiceal carcinoid tumor.
BACKGROUND
Pregnancy after cytoreductive surgery and intraperitoneal chemotherapy is rare.


METHODS
We present the case of a 25-year-old woman with appendiceal carcinoid tumor treated with intraperitoneal cisplatin for peritoneal recurrence after a fertility-sparing cytoreductive procedure. Five years after her procedure, she conceived with the help of assisted reproductive technologies and delivered a viable term fetus via cesarean delivery. She subsequently had a successful second pregnancy and is currently alive without evidence of her disease.


CONCLUSIONS
Conception is possible after tumor debulking and intraperitoneal chemotherapy. In unique clinical situations, fertility-sparing surgery may be considered in young patients who desire future pregnancy.
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. mantiagm@upmc.edu
Gina M Mantia
GM
Smaldone
Scott D
SD
Richard
Thomas C
TC
Krivak
Joseph L
JL
Kelley
Robert P
RP
Edwards
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001063:Appendiceal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D002276:Carcinoid Tumor / Q000188:drug therapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced / Q000628:therapy*; D007263:Infusions, Parenteral; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted
D000970:Antineoplastic Agents; D002945:Cisplatin