Stability of the OECD model compound benzoic acid in receptor fluids of Franz diffusion cells.
The stability of benzoic acid, one of the model compounds recommended for skin absorption studies in the OECD guidelines, in Franz diffusion cell receptor fluids was studied. According to the results, addition of a preservative (sodium azide) to the solution is recommended for long-term skin permeation experiments.
Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Belgium.
S
S
Bodé
B
B
Baert
M
M
Vangele
J
J
Lambert
C
C
Burvenich
G
G
Slegers
B
B
De Spiegeleer
D019817:Benzoic Acid / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D015194:Diffusion Chambers, Culture; D004355:Drug Stability; D006801:Humans; D066298:In Vitro Techniques; D012869:Skin Absorption; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
D019817:Benzoic Acid