[Hemostatic system parameters of placental extracts in normal pregnancy and severe preeclampsia].
To better understand the role of the hemostatic mechanism in preeclampsia, placental extracts obtained from 26 normal pregnant women (NP) and 12 patients with severe pre-eclampsia (SPE) were analyzed to determine thrombomodulin (TM), tissue factor (TF), tissue-type plasminogen activator (tPA), plasminogen activator inhibitor (PAI) 1 and 2, and TF pathway inhibitor (TFPI). The results showed similar concentrations of TF, TM and PAI-2 in both groups, while tPA increased no significantly and TFPI and PAI-1 increased significantly in SPE placentas.
Centro de Bioquímica y Biofísica y Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela. ysabel_lopez@hotmail.com
Ysabel
Y
López-Ramírez
Zoila
Z
Carvajal
Carmen Luisa
CL
Arocha-Piñango
D000293:Adolescent; D000328:Adult; D001779:Blood Coagulation Factors / Q000032:analysis*; D005260:Female; D006487:Hemostasis; D006801:Humans; D010920:Placenta / Q000737:chemistry*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012720:Severity of Illness Index
D001779:Blood Coagulation Factors