Progeria (Hutchison-Gilford syndrome) in siblings: in an autosomal recessive pattern of inheritance.
Progeria is an autosomal dominant, premature aging syndrome. Six and three year old female siblings had sclerodermatous changes over the extremities, alopecia, beaked nose, prominent veins and bird-like facies. Radiological features were consistent with features of progeria. The present case highlights rarity of progeria in siblings with a possible autosomal recessive pattern.
Department of Skin and Sexually Transmitted Diseases, Viydyanagar Institute of Medical Sciences, Government Medical College, Bellary-583 104, Karnataka, India.
T Y
TY
Raghu
G A
GA
Venkatesulu
G R
GR
Kantharaj
T
T
Suresh
V
V
Veeresh
Y
Y
Hanumanthappa