A degradation product of halobetasol propionate: characterization and structure.
Degradation of halobetasol propionate was observed in the presence of bases. A single cyclization product was isolated and fully characterized by MS, NMR and X-ray crystallography.
Dipartimento di Scienza e Tecnologia del Farmaco, Via Giuria 9, 10125, Torino, Italy.
Giancarlo
G
Cravotto
Giovanni B
GB
Giovenzana
Norberto
N
Masciocchi
Giovanni
G
Palmisano
Paolo
P
Volante
D002384:Catalysis; D002990:Clobetasol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D014662:Vasoconstrictor Agents / Q000737:chemistry* / Q000378:metabolism*
D014662:Vasoconstrictor Agents; C064466:halobetasol; D002990:Clobetasol