[Quantitative methylation-specific PCR for the diagnosis of lung cancer].
Efficient, preferably early diagnosis of lung cancer represents a major challenge. Under this aspect the sensitivity of conventional histomorphology and cytomorphology procedures is unsatisfactory. This review highlights technical aspects, possibilities and drawbacks of the application of aberrant promoter methylation as a biomarker for lung cancer diagnostics using specimens of pulmonary exfoliative cytology.
Institut für Cytopathologie, Universität Düsseldorf. hans-juergen.grote@merck.de
H J
HJ
Grote
V
V
Schmiemann
M
M
Kazimirek
A
A
Böcking
D019175:DNA Methylation; D005819:Genetic Markers; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D016133:Polymerase Chain Reaction / Q000379:methods*; D011401:Promoter Regions, Genetic; D012680:Sensitivity and Specificity
D005819:Genetic Markers