Direct use of allylic alcohols for platinum-catalyzed monoallylation of amines.
A new direct catalytic amination of allylic alcohols promoted by the combination of platinum and a large bite-angle ligand DPEphos was developed in which the allylic alcohol was effectively converted to a pi-allylplatinum intermediate without the use of an activating reagent. The use of the DPEphos ligand was essential for obtaining high catalyst activity and high monoallylation selectivity of primary amines, allowing the formation of a variety of monoallylation products in good to excellent yield.
Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan.
Masaru
M
Utsunomiya
Yoshiki
Y
Miyamoto
Junji
J
Ipposhi
Takashi
T
Ohshima
Kazushi
K
Mashima
D000498:Allyl Compounds / Q000138:chemical synthesis*; D000586:Amination; D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D010984:Platinum / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*
D000498:Allyl Compounds; D000588:Amines; D020005:Propanols; C006463:allyl alcohol; D010984:Platinum