Non-choreic movement disorders as initial manifestations of Huntington's disease.
We describe seven patients with genetically confirmed Huntington's disease (HD) who had non-choreic movement disorders as presenting symptoms or signs. Patients with movement disorders other than chorea in the early stages tended to have larger CAG trinucleotide repeat expansion in comparison with more "typical" HD patients.
Movement Disorders Unit, Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil.
Nilson
N
Becker
Renato P
RP
Munhoz
Salmo
S
Raskin
Lineu César
LC
Werneck
Hélio A G
HA
Teive
D000328:Adult; D004421:Dystonia / Q000175:diagnosis / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000175:diagnosis / Q000235:genetics; D016133:Polymerase Chain Reaction; D020323:Tics / Q000175:diagnosis / Q000235:genetics; D014057:Tomography, X-Ray Computed; D019680:Trinucleotide Repeat Expansion / Q000235:genetics*