The control of impurities in amitriptyline hydrochloride using a reversed-phase hybrid stationary phase.
An isocratic reversed-phase liquid chromatographic method is described using a hybrid column for the control of synthetic impurities potentially found in amitriptyline hydrochloride. The method has been validated and is capable of controlling impurities to 0.1 per cent.
Dixon
S P
SP
Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, UK.
Lodi
A
A
Miller
J H M
JH
Skellern
G G
GG
D000639:Amitriptyline / Q000031:analogs & derivatives / Q000032:analysis* / Q000737:chemistry; D000929:Antidepressive Agents, Tricyclic / Q000032:analysis / Q000737:chemistry; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D003986:Dibenzocycloheptenes / Q000032:analysis / Q000737:chemistry; D004340:Drug Contamination / Q000517:prevention & control*; D004355:Drug Stability; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D015203:Reproducibility of Results; D013696:Temperature; D013997:Time Factors; D014783:Viscosity
D000929:Antidepressive Agents, Tricyclic; D003986:Dibenzocycloheptenes; D000639:Amitriptyline; C004704:cyclobenzaprine; C011222:dibenzsuberone