The relationship between cotinine and periodontal disease.
Smoking is a risk factor for periodontitis but there are conflicting reports about the relationship between the severity of periodontitis and smoking behaviour, in part because self-reported smoking status may be inaccurate. Cotinine, a major metabolite of nicotine with a longer half-life (17 h versus 30 min), may be a more useful biochemical marker of smoking status. Smoking behaviour, plasma cotinine levels, and measures of periodontitis severity in 135 adults with moderate-advanced periodontitis were studied. Smokers had comparable periodontitis at a younger age than non-smokers. Smoking, as measured by cigarettes smoked per day and plasma cotinine levels, was significantly related to the severity of periodontitis.
University of Sydney.
Natalie M
NM
Leow
Marie-Christine
MC
Morel-Kopp
Mark
M
Woodward
Qiang
Q
Chen
Geoffrey H
GH
Tofler
Barbara A
BA
Taylor
D000328:Adult; D003367:Cotinine / Q000097:blood*; D006801:Humans; D010518:Periodontitis / Q000097:blood / Q000209:etiology* / Q000473:pathology; D012907:Smoking / Q000009:adverse effects*
D003367:Cotinine