Risk factors for para-aortic lymph node metastasis of gastric cancer from a randomized controlled trial of JCOG9501.
BACKGROUND
No risk factor has been confirmed for para-aortic lymph node (PAN) metastasis from gastric cancer. To identify the risk factors and the most frequent route of metastasis to PAN, we analyzed the prospective data from a phase III trial.


METHODS
In JCOG9501 comparing D2 and D2 + PAN dissection, 260 patients with T2(SS)-T4 gastric cancer underwent radical gastrectomy with PAN dissection. The association between various clinicopathological factors and PAN metastasis was examined.


RESULTS
Macroscopic N stage and tumor size > or = 5 cm were significant risk factors for PAN metastasis after adjusting for other factors. The proportion of PAN metastasis was clearly different between the N0-1 group and the N2-4 group (2.8% versus 20.5%). In the additional multivariate analysis including 17 regional lymph node stations, station No. 7 was the only station with statistical significance (P = 0.002, odds ratio = 41.0).


CONCLUSIONS
Macroscopic N stage and tumor size were associated with PAN metastasis, and the lymphatics along the left gastric artery seemed to be the most frequent route to the nodes surrounding the aorta. These findings may be useful in predicting PAN metastasis.
Nomura
Eiji
E
Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Osaka, Japan. sur035@poh.osaka-med.ac.jp
Sasako
Mitsuru
M
Yamamoto
Seiichiro
S
Sano
Takeshi
T
Tsujinaka
Toshimasa
T
Kinoshita
Taira
T
Furukawa
Hiroshi
H
Shimizu
Toshio
T
Hiratsuka
Masahiro
M
Kobayashi
Osamu
O
Kurokawa
Yukinori
Y
Tanigawa
Nobuhiko
N
D000328:Adult; D000368:Aged; D001011:Aorta; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology*