Stochastic resonant signaling in enzyme cascades.
We observe the phenomenon of stochastic resonant signaling in signal amplification enzyme cascades, where certain optimal reaction rates minimize the average threshold-crossing time. We develop a new analytical technique to obtain the mean first passage time, based on a novel decomposition of the master equation. Our analytical results are in good agreement with the exact numerical simulations. We demonstrate that resonant behavior may be a ubiquitous phenomenon in stochastic threshold crossing in cell signaling. The physical principles behind this phenomenon are elucidated.
Department of Chemistry, University of North Carolina at Chapel Hill, North Carolina 27599-3290, USA.
Yueheng
Y
Lan
Garegin A
GA
Papoian
D055592:Biophysical Phenomena; D001703:Biophysics; D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D013269:Stochastic Processes
D004798:Enzymes