Chemoselective derivatization of alkaloids in periwinkle.
The terpene indole alkaloid biosynthetic pathway can utilize a secologanin substrate analog containing a handle for functionalization, and the resulting non-natural alkaloids can be chemoselectively derivatized in crude extracts of plant tissue.
Galan
M Carmen
MC
Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
McCoy
Elizabeth
E
O'Connor
Sarah E
SE
D000470:Alkaloids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D031053:Vinca / Q000737:chemistry*
D000470:Alkaloids; D010936:Plant Extracts