Cogitation about free radicals and oxidative stress--an old concept with many new limitations.
Since its creation, the concept of OS became very popular. Manifestations of the OS were investigated, verified, proved and disproved in thousands of studies. However, the enormous amount of knowledge about OS that accumulated in the last decades had dual influence: it extended the original concept of OS considerably, often even in an undesirable way, but it also pointed to its vulnerability. The present treatise is a cogitation about some main limitations that can make the original concept of OS outdated. No matter whether outdated or only less exact, it would be better to think it over three times prior using the term OS.
Ziegelhöffer
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Institute for Heart Research, Centre of Excellence for Cardiovascular Research of Slovak Academy of Sciences, Dúbravská cesta 9, 840 05 Bratislava 45, Slovakia. usrdzigy@savba.sk
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002451:Cell Compartmentation / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D005609:Free Radicals / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000032:analysis / Q000378:metabolism*; D009626:Terminology as Topic
D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species