[Prospects for leprosy treatment via complexation of rifampicin witH iodide and horse-radish root].
A model of leprosy was used to study the therapeutic effect of horse-radish root (HRR) containing peroxidase in combination with rifampicin (RFP) and potassium iodide (PI) as compared to routine combined therapy with RFP and diaminodiphenylsulfonum. Therapy with HRR and iodide showed the best antimicrobial effect than the routine combined therapy. A combination of RFP, HRR, and PI increased the activity of neutrophilic myeliperoxidase produced an anti-inflammatory activity and caused no persistent anemia or toxic effect on the murine liver.
Maslov
A K
AK
Khivrina
S A
SA
D000818:Animals; D031215:Armoracia / Q000201:enzymology; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D006735:Horseradish Peroxidase / Q000032:analysis / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy*; D051379:Mice; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D009195:Peroxidase / Q000032:analysis / Q000378:metabolism; D018517:Plant Roots / Q000201:enzymology; D011193:Potassium Iodide / Q000627:therapeutic use*; D012293:Rifampin / Q000627:therapeutic use*; D016896:Treatment Outcome
D011193:Potassium Iodide; D006735:Horseradish Peroxidase; D009195:Peroxidase; D012293:Rifampin