Beta-catenin and CD44 expression in keratoacanthoma and squamous cell carcinoma of the skin.
CD44 and beta-catenin are adhesion molecules expressed on a wide variety of cells. Failure of this expression is believed to lead to disruption of cell-cell adhesion and to neoplasia. The aim of this study was to investigate the staining intensity of CD44 and beta-catenin in keratoacanthomas and squamous cell carcinomas of the skin. The proliferation index, PCNA staining, was also evaluated in these cases. The abnormal expression of beta-catenin significantly predominated in squamous cell carcinomas (n = 20, 76.9%) compared with keratoacanthomas (P = 0.002, chi2 = 7.8). Most keratoacanthomas (n = 11, 61.1%) more frequently showed strong staining intensity with CD44 compared with squamous cell carcinoma (P= 0.001, chi2 = 13.7). The proliferation index was higher in squamous cell carcinoma (P = 0.000, chi2 = 12.8). These findings suggest that CD44 and beta-catenin expression may have an important role in the development of malignancy and in the determination of biological features of keratoacanthoma and squamous cell carcinoma of the skin.
Tataroglu
Canten
C
Adnan Menderes University School of Medicine, Department of Pathology, Aydin, Turkey. cantent@yahoo.com
Karabacak
Tuba
T
Apa
Duygu Düşmez
DD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D002455:Cell Division; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D007124:Immunoenzyme Techniques; D007636:Keratoacanthoma / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D012867:Skin; D012871:Skin Diseases / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D051176:beta Catenin / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics
C497483:CD44 protein, human; C495270:CTNNB1 protein, human; D018960:Hyaluronan Receptors; D009363:Neoplasm Proteins; D018809:Proliferating Cell Nuclear Antigen; D051176:beta Catenin