Fatal brain infection caused by Aspergillus glaucus in an immunocompetent patient identified by sequencing of the ribosomal 18S-28S internal transcribed spacer.
Cerebral aspergillosis has rarely been reported in immunocompetent patients. We herein describe a unique case of cerebral aspergillosis in a healthy adult that led to his death despite aggressive antifungal therapy. Sequencing of ribosomal 18S-28S internal transcribed spacer identified the organism as Eurotium herbariorum, the teleomorph of Aspergillus glaucus.
Traboulsi
R S
RS
Division of Infectious Diseases, American University of Beirut Medical Center, P.O. Box 113-6044, Hamra, Beirut, 110 32090, Lebanon.
Kattar
M M
MM
Dbouni
O
O
Araj
G F
GF
Kanj
S S
SS
D000328:Adult; D001230:Aspergillus / Q000235:genetics* / Q000302:isolation & purification; D001927:Brain Diseases / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D017809:Fatal Outcome; D006801:Humans; D007121:Immunocompetence; D008297:Male; D020953:Neuroaspergillosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D012337:RNA, Ribosomal, 18S / Q000235:genetics*; D012339:RNA, Ribosomal, 28S / Q000235:genetics*
D021903:DNA, Ribosomal Spacer; D012337:RNA, Ribosomal, 18S; D012339:RNA, Ribosomal, 28S