Membrane permeable esterase-activated fluorescent imaging probe.
An esterase-triggered probe 2 derived from a cyanine-based pH sensitive dye was developed for cell labeling. Permeation of probe 2 into cells and subsequent hydrolytic activation by cellular esterases result in a bright fluorescent intracellular signal.
Kim
Youngmi
Y
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Choi
Yongdoo
Y
Weissleder
Ralph
R
Tung
Ching-Hsuan
CH
D002463:Cell Membrane Permeability; D004950:Esterases / Q000378:metabolism*; D008856:Microscopy, Fluorescence
D004950:Esterases