[The prevalence and risk factors of drug-resistant tuberculosis among migratory population in Shanghai, China].
OBJECTIVE
To determine the prevalence of and risk factors for drug-resistant tuberculosis among migratory population in Shanghai.


METHODS
All sputum culture positive patients among migratory population, confirmed at any district (county) tuberculosis dispensary in Shanghai from February 2004 to January 2005, were enrolled. The drug susceptibility test was performed by the proportion method. Univariate and multivariate analysis were performed to determine the risk factors associated with drug resistance.


RESULTS
493 patients were enrolled during the study period, among whom 431 patients had bacterial identification and drug susceptibility results. Of the 431 strains, 427 (99.1%) strains were Mycobacterium tuberculosis and 4 (0.9%) strains were Mycobacterium non-tuberculosis. The prevalence of drug-resistant tuberculosis among new cases and re-treatment cases was 16.0% (62/387) and 40.0% (16/40), respectively. The prevalence of MDR-tuberculosis among new cases and re-treatment cases was 4.1% (16/387) and 22.5% (9/40), respectively. A history of previous treatment for tuberculosis and age group of 45 - 60 years were significantly associated with drug resistance.


CONCLUSIONS
The prevalence of drug-resistant tuberculosis among migratory population was relatively high in Shanghai, suggesting the necessity to strengthen the tuberculosis control program for migratory population.
Key Laboratory of Medical Molecular Virology of Ministry of Education, Shanghai Medical School, Fudan University, Shanghai 200032, China.
Xin
X
Shen
Mei
M
Shen
Xiao-hong
XH
Gui
Qian
Q
Gao
Jian
J
Mei
D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011157:Population Dynamics; D015995:Prevalence; D012307:Risk Factors; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000453:epidemiology*; D055815:Young Adult
D000995:Antitubercular Agents