Pulmonary versus systemic delivery of antibiotics: comparison of vancomycin dispositions in the isolated rat lung.
Vancomycin dispositions in the respiratory system were compared after systemic and inhalatory administration under two respiratory conditions using the isolated-lung model. Inhalatory delivery led to much higher drug levels in pulmonary tissue and fluids. The respiratory pattern affects vancomycin disposition in the pulmonary system regardless of the administration route.
Pharmacy Department, University of Salamanca, Licenciado Méndez Nieto, s/n 37007, Salamanca, Spain.
María José
MJ
de Jesús Valle
Francisco González
FG
López
Alfonso Domínguez-Gil
AD
Hurlé
Amparo Sánchez
AS
Navarro
D000280:Administration, Inhalation; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001826:Body Fluids / Q000187:drug effects / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D008297:Male; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012121:Respiration, Artificial; D015656:Respiratory Mechanics / Q000502:physiology; D014640:Vancomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D014640:Vancomycin