Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma with a CD15(+)CD30(-) phenotype.
Primary cutaneous aggressive epidermotropic CD8(+) T-cell lymphoma (CD8(+)TCL) is an extremely rare entity with distinct clinicopathological features. While the CD15 antigen is typically associated with classic Hodgkin's lymphoma, aggressive peripheral T-cell lymphomas, including advanced stage cutaneous T-cell lymphomas, rarely express this molecule. We report a case of primary cutaneous aggressive epidermotropic CD8(+)TCL, in which lymphoma cells are CD15(+)CD30(-) with a medium-to-large pleomorphic phenotype. Although the functional characteristics of CD15 expression in the cutaneous lymphomas are not fully understood, the poor prognosis of primary cutaneous aggressive epidermotropic CD8(+)TCL might be associated with the presence of this molecule in our case.
Department of Dermatology, Shizuoka Municipal Shimizu Hospital, 1231 Miyakami Shimizu, Shizuoka 424-8636, Japan. naho@suite.plala.or.jp
Naho
N
Yoshizawa
Hiroaki
H
Yagi
Takahiro
T
Horibe
Masahiro
M
Takigawa
Makoto
M
Sugiura
D000368:Aged; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis*; D016256:Lewis X Antigen / Q000032:analysis*; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D011379:Prognosis; D012878:Skin Neoplasms / Q000175:diagnosis / Q000276:immunology*
D017730:Ki-1 Antigen; D016256:Lewis X Antigen