The 2006 Pittendrigh/Aschoff lecture: new roles for old proteins in the Drosophila circadian clock.
Circadian behaviors in the animal kingdom are regulated by a small set of conserved genes. Starting with a historical perspective focused on Drosophila, the authors describe how the recurrent discovery of circadian clock genes uncovered a molecular mechanism associated with cycling gene expression. These molecular cycles appear to emerge from delayed negative and positive feedback. The authors will then introduce a novel timing mechanism uncovered by a single cell-based assay, with the new ideas and prospects for future research that it has raised.
Laboratory of Genetics, The Rockefeller University, New York, NY10021, USA. young@rockefeller.edu
Pablo
P
Meyer
Michael W
MW
Young
D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins / Q000378:metabolism*; D025461:Feedback, Physiological; D031541:Fluorescence Resonance Energy Transfer; D005544:Forecasting; D005786:Gene Expression Regulation; D008954:Models, Biological
D029721:Drosophila Proteins