Does diagnostic classification of early-onset psychosis change over follow-up?
OBJECTIVE
To examine the diagnostic stability and the functional outcome of patients with early-onset psychosis (EOP) over a 2-year follow-up period.


METHODS
A total of 24 patients (18 males (75%) and 6 females (25%), mean age +/- SD: 15.7 +/- 1.6 years) with a first episode of EOP formed the sample. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Social disability was measured with the Global Assessment of Functioning (GAF) disability scale. Diagnosis was assessed using the Kiddie-Sads-Present and Lifetime Version (K-SADS-PL), according to DSM-IV criteria. All diagnoses were re-assessed after 1 year and 2 years.


RESULTS
Schizophrenia had the highest prospective consistency (100% predictive value), while diagnostic stability was moderate for bipolar disorder (71.4%), and low for schizoaffective disorder (50%), schizophreniform and brief psychosis (50%), and psychosis not otherwise specified (NOS) (16.7%). The agreement between the baseline diagnoses and the 1-year follow-up diagnoses was 54.2%, whereas between the 1-year follow-up and the 2-year follow-up, it rose to 95.7%. Regardless of diagnosis, baseline negative symptoms were the only significant predictor of level of functioning at the 2-year follow-up (p = 0.010).


CONCLUSIONS
Our results highlight the primacy of the first-year follow-up diagnosis in predicting diagnostic stability of EOP.
Department of Psychiatry, Hospital General Universitario Gregorio Marañón, Ibiza 43, CP 28009, Madrid, Spain. dfraguash@yahoo.es
David
D
Fraguas
María J
MJ
de Castro
Oscar
O
Medina
Mara
M
Parellada
Dolores
D
Moreno
Montserrat
M
Graell
Jessica
J
Merchán-Naranjo
Celso
C
Arango
D000293:Adolescent; D001714:Bipolar Disorder / Q000175:diagnosis / Q000628:therapy; D002648:Child; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016013:Likelihood Functions; D016014:Linear Models; D008297:Male; D011237:Predictive Value of Tests; D011581:Psychological Tests; D011618:Psychotic Disorders / Q000175:diagnosis*; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000175:diagnosis / Q000628:therapy; D013030:Spain; D013997:Time Factors