[Antiherpetic effect of RNA-tilorone molecular complex in cell culture].
The authors studied the antiviral effect of an interferonogenic yeast RNA-tilorone molecular complex (MC) compared to the Virolex, videly used antiherpetic drug, and standard interferon (IFN) alpha/beta inducer poly(I)poly(C) in Vero cells culture infected with herpes simplex type I virus (HSV-1). The tilorone contained by MC has been shown to be twice less toxic and twice more active against HSV than its free molecules. The value of chemotherapeutic index (CI) of Virolex in experiments with Vero cells reaches 2500, CI poly(I)poly(C) and MC being 324; the last value meets the requirements for promising drugs.
O I
OI
Skrots'ka
N M
NM
Zholobak
S V
SV
Antonenko
M Ia
MIa
Spivak
O V
OV
Karpov
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D007369:Interferon Inducers / Q000494:pharmacology*; D012331:RNA, Fungal / Q000302:isolation & purification / Q000494:pharmacology*; D012335:RNA, Ribosomal / Q000302:isolation & purification / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013994:Tilorone / Q000494:pharmacology*; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D007369:Interferon Inducers; D012331:RNA, Fungal; D012335:RNA, Ribosomal; D013994:Tilorone