Mid-dilution: an innovative high-quality and safe haemodiafiltration approach.
Mid-dilution (MidD) is a new concept allowing post- and predilution in the same dialyser (Olpur MD 190). The aim of the study was to compare, in 6 patients, MidD with post and predilution wird regard to purification tests, such as reduction ratios and instantaneous whole-blood clearances, of urea, creatinine and phosphorus as examples of low-weight molecules and of Beta2-microglobulin as an example of a middle molecule (MM). The aim was also to indicate directions for the use of this new dialyser, taking into account our own experience and the few observations already published. It was concluded that MidD, under excellent safety conditions, in spite of increased intradialyser pressures, offers a very high purification performance, particularly for MM, because of high convective volumes exceeding the recommended objectives for a better survival in dialysis.
Centre Hospitalier Louis-Pasteur, Cherbourg, France.
Jacky
J
Potier
D004867:Equipment Design; D017583:Hemodiafiltration / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D015312:Hemodialysis Solutions / Q000592:standards*; D006801:Humans; D011786:Quality Control; D016896:Treatment Outcome
D015312:Hemodialysis Solutions