Direct use of allylic alcohols for platinum-catalyzed monoallylation of amines.
A new direct catalytic amination of allylic alcohols promoted by the combination of platinum and a large bite-angle ligand DPEphos was developed in which the allylic alcohol was effectively converted to a pi-allylplatinum intermediate without the use of an activating reagent. The use of the DPEphos ligand was essential for obtaining high catalyst activity and high monoallylation selectivity of primary amines, allowing the formation of a variety of monoallylation products in good to excellent yield.
Utsunomiya
Masaru
M
Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan.
Miyamoto
Yoshiki
Y
Ipposhi
Junji
J
Ohshima
Takashi
T
Mashima
Kazushi
K
D000498:Allyl Compounds / Q000138:chemical synthesis*; D000586:Amination; D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D010984:Platinum / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*
D000498:Allyl Compounds; D000588:Amines; D020005:Propanols; C006463:allyl alcohol; D010984:Platinum