Relationship between hyperuricemia and metabolic syndrome.
OBJECTIVE
To investigate the relationship between metabolic syndrome and hyperuricemia.


METHODS
A total of 2 374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our study. Hyperuricemia is defined as >or=7 mg/dl (in men) or >or=6.0 mg/dl (in women). Metabolic syndrome was defined using AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria.


RESULTS
(1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%). (2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased risk of metabolic syndrome as compared with those without hyperuricemia [odds ratio (OR)=1.634, P=0.000]. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia.


CONCLUSIONS
Hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic syndrome.
Department of Family Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. cly0906@163.com
Li-ying
LY
Chen
Wen-hua
WH
Zhu
Zhou-wen
ZW
Chen
Hong-lei
HL
Dai
Jing-jing
JJ
Ren
Jian-hua
JH
Chen
Lei-qian
LQ
Chen
Li-zheng
LZ
Fang
D000328:Adult; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000453:epidemiology / Q000652:urine*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology / Q000652:urine*; D012307:Risk Factors; D012727:Sex Characteristics; D014527:Uric Acid / Q000652:urine
D014527:Uric Acid