The control of impurities in amitriptyline hydrochloride using a reversed-phase hybrid stationary phase.
An isocratic reversed-phase liquid chromatographic method is described using a hybrid column for the control of synthetic impurities potentially found in amitriptyline hydrochloride. The method has been validated and is capable of controlling impurities to 0.1 per cent.
Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, UK.
S P
SP
Dixon
A
A
Lodi
J H M
JH
Miller
G G
GG
Skellern
D000639:Amitriptyline / Q000031:analogs & derivatives / Q000032:analysis* / Q000737:chemistry; D000929:Antidepressive Agents, Tricyclic / Q000032:analysis / Q000737:chemistry; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D003986:Dibenzocycloheptenes / Q000032:analysis / Q000737:chemistry; D004340:Drug Contamination / Q000517:prevention & control*; D004355:Drug Stability; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D015203:Reproducibility of Results; D013696:Temperature; D013997:Time Factors; D014783:Viscosity
D000929:Antidepressive Agents, Tricyclic; D003986:Dibenzocycloheptenes; D000639:Amitriptyline; C004704:cyclobenzaprine; C011222:dibenzsuberone