Developments in asymmetric hydrogenation from an industrial perspective.
Examples of developments in asymmetric hydrogenation from various perspectives, in an effort to improve efficiency, are reported. Discussed in this Account are (1) the improved synthesis of BINAP ligands, (2) the design of SEGPHOS ligands for higher enantioselectivity, (3) a new protocol with fewer reaction steps to synthesize beta-aminoesters, and (4) a novel asymmetric hydrogenation mediated by a copper catalyst.
Takasago International Corporation, Corporate Research & Development Division, 1-4-11 Nishi-yawata, Hiratsuka City, Kanagawa 254-0073, Japan. hideo_shimizu@takasago.com
Hideo
H
Shimizu
Izuru
I
Nagasaki
Kazuhiko
K
Matsumura
Noboru
N
Sayo
Takao
T
Saito