[Effect of the nitric oxide donors Na nitroprusside and L-arginine on the course of uveitis, the antioxidative and antiproteolytic potential of tear and blood in the experiment].
The nitric oxide (NO) donors Na nitroprusside and L-arginine were tested for their effects on the course of experimental immunogenic uveitis, antiproteolytic and antioxidative activities in the rabbit tear and blood. With the use of the NO donors, the course of uveitis was shown to be more severe and prolonged. In uveitis, there was a change in the activity of the antiproteinases--alpha1-antitrypsin and alpha2-macroglobulin and the antioxidative enzymes superoxide dismutase in both tear and blood. The magnitude of changes in the biochemical parameters under study suggested that the course of uveitis was more severe in the rabbits given the NO donors. Thus, the inclusion of the NO donors in the active phase enhances an inflammatory reaction in immunogenic uveitis.
Neroev
V V
VV
Chesnokova
N B
NB
Davydova
G A
GA
Davydova
N G
NG
Perova
T S
TS
Stoliarova
E P
EP
Beznos
O V
OV
D000818:Animals; D001120:Arginine / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D020030:Nitric Oxide Donors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D009599:Nitroprusside / Q000493:pharmacokinetics* / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism; D013666:Tears / Q000378:metabolism*; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy* / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D015415:Biomarkers; D020030:Nitric Oxide Donors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D009599:Nitroprusside; D001120:Arginine; D013482:Superoxide Dismutase