Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities.
For the development of novel antitumor agents, we designed and synthesized 2,6-diaryl-substituted pyridine derivatives bearing three aryl groups, which are the bioisosteres of terpyridine, and evaluated their biological activities. Most of the 18 prepared compounds showed moderate cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that the number of aryl groups employed would be critical for their biological activities.
College of Pharmacy, Yeungnam University, Kyongsan 712-749, South Korea.
Jong-Keun
JK
Son
Long-Xuan
LX
Zhao
Arjun
A
Basnet
Pritam
P
Thapa
Radha
R
Karki
Younghwa
Y
Na
Yurngdong
Y
Jahng
Tae Cheon
TC
Jeong
Byeong-Seon
BS
Jeong
Chong-Soon
CS
Lee
Eung-Seok
ES
Lee
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011725:Pyridines; D059004:Topoisomerase I Inhibitors