Highly efficient ruthenium-catalyzed oxime to amide rearrangement.
A wide range of aldoximes has been converted into the corresponding amides using the ruthenium-based catalyst Ru(PPh3)3(CO)H2/dppe/TsOH. The amides are generated in high yield and selectivity, with catalyst loading as low as 0.04 mol %.
Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Nathan A
NA
Owston
Alexandra J
AJ
Parker
Jonathan M J
JM
Williams
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
D000577:Amides; D009942:Organometallic Compounds; D010091:Oximes; D012428:Ruthenium