Involvement of glutathione in puberty and FSH release.
Administration of glutathione subcutaneously to immature female (age and weight matched) rats brings about a pre-ponement of puberty. A significant increase in pituitary, ovaries and uterine mass was observed in the experimental rats. Further, a considerable increase in pituitary FSH levels was also observed after intraventricular injection of glutathione in ovariectomized-steroid primed rats. Intraventricular administration of L-buthionine SR sulfoxamine produced a significant decrease in plasma FSH levels in intact male rats. These studies demonstrate the neuroendocrine role of glutathione on gonadotropins, specifically in relation to FSH release.
Department of Biochemistry, Nizam's Institute of Medical Sciences, Hyderabad 500482, AP, India. kotwal4pasha@yahoo.co.in
K
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Vali Pasha
D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D019328:Buthionine Sulfoximine / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism / Q000502:physiology*; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D010052:Ovariectomy; D010053:Ovary / Q000187:drug effects / Q000502:physiology; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012741:Sexual Maturation / Q000502:physiology*; D014599:Uterus / Q000187:drug effects / Q000502:physiology
D000963:Antimetabolites; D019328:Buthionine Sulfoximine; D005640:Follicle Stimulating Hormone; D005978:Glutathione