Carnitine and lipoate ameliorates lipofuscin accumulation and monoamine oxidase activity in aged rat heart.
In this study we have focused on the levels of lipofuscin, monoamine oxidase and cholesterol phospholipid ratio in the heart muscle of young, middle aged and aged rats. In parallel, we have also investigated the levels of carnitine and lipoic acid during aging. We observed an increase in lipofuscin accumulation and monoamine oxidase activity in both middle aged and aged rats. Levels of both carnitine and lipoic acid decreased along with a decrease in cholesterol phospholipid ratio. These changes were normalized upon cosupplementation of carnitine and lipoic acid. Our results thus reveal that carnitine along with lipoic acid can be used as an effective supplement against free radical induced damage to the cardiac tissue.
Savitha
Sethumadhavan
S
Department of Medical Biochemistry, Dr. ALMPG Institute of Basic Medical Science, University of Madras, Taramani, Chennai 600113, India.
Naveen
Balasubramanian
B
Panneerselvam
Chinnakannu
C
D000375:Aging / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002331:Carnitine / Q000494:pharmacology*; D019587:Dietary Supplements; D066298:In Vitro Techniques; D008062:Lipofuscin / Q000378:metabolism*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000494:pharmacology*
D000975:Antioxidants; D008062:Lipofuscin; D008063:Thioctic Acid; D008995:Monoamine Oxidase; D002331:Carnitine