[The dependence of changes of parameters of metabolic syndrome features on the reduction of degree of insulin resistance during lifestyle intervention].
The aim of our investigation was to study the dependence of changes of parameters of metabolic syndrome (MS) features on the reduction of degree of insulin resistance during lifestyle intervention--balanced diet and moderate exercise. 33 patients with MS have been investigated (mean age--49.1+/-8.7 years). MS was confirmed by WHO definition of 2002. All parameters of MS features have been determined baseline and after 6 months of study initiation. Balanced diet (restriction of easy-digestible carbohydrates and lipids and consumption of products with high cellulose content) and moderate exercise (60 min. walking three times per week) have been prescribed to all patients. After 6 months IR index was decreased from 3.6+/-0.7 to 2.6+/-0.4 (p<0.001). Investigated subjects were divided on two groups: I group consisted of patients HOMA-IR index of whom after 6 months decreased by magnitude less than 1.0 (n=19); and II group--patients HOMA-IR index of whom after 6 months decreased by magnitude greater or equal 1.0 (n=14). In spite of similar reduction of body mass and waist circumference, the parameters of carbohydrate and lipid metabolism in II group decreased significantly sharply than in I group. The more positive changes of metabolic parameters of MS features during lifestyle intervention strongly depend on the degree of reduction of insulin resistance which has to become the main strategic target during MS treatment.
Shengeliia
I B
IB
Virsaladze
D K
DK
Dzhavashvili
L V
LV
Tananashvili
D E
DE
D000328:Adult; D008078:Cholesterol, LDL / Q000378:metabolism; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism / Q000503:physiopathology*; D008875:Middle Aged
D008078:Cholesterol, LDL