One-pot synthesis of new A-ring fused steroidal pyridines.
The preparation of pyridine rings fused to the 3,4-positions of the steroid nucleus is herein described. These new pyridine derivatives were prepared in good yields by the reaction of propargylamine with 17beta-hydroxyandrost-4-en-3-one, 17alpha-methyl-17beta-hydroxyandrost-4-en-3-one, 17beta-hydroxyestr-4-en-3-one catalyzed by Cu(II). The structure of 17beta-hydroxy-5-ene-androst-3-eno[3,4-b]pyridine was determined by X-ray analysis.
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, PR China. zyx@zjut.edu.cn
Ji-Zhong
JZ
Yan
Jian
J
Li
Guo-Wu
GW
Rao
D002625:Chemistry, Organic / Q000379:methods*; D008968:Molecular Conformation; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry*
D011725:Pyridines; D013256:Steroids; C023666:pyridine