[Oxysterols: genesis and basic functions].
The structural peculiarities of the most widespread oxysterols, the products of oxidative transformations of cholesterol are discussed. The transformations proceed with the participation of enzymatic systems of the body or as a result of various nonenzymatic reactions. The pathways of their formation from cholesterol are also considered. The role of oxysterols in the maintenance of cholesterol homeostasis and in the development of atherosclerosis is reviewed. The possibility of using oxysterols as markers of pathological processes is demonstrated.
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Antonchik
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Zhabinskiĭ
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Khripach
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism; D001693:Biological Transport, Active; D015415:Biomarkers / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D006888:Hydroxycholesterols / Q000737:chemistry / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D010084:Oxidation-Reduction
D015415:Biomarkers; D006888:Hydroxycholesterols; D002784:Cholesterol