[Efficacy of ibuprofen (nurofen gel) ultraphonophoresis for pain relief in osteoarthrosis].
To compare efficacy of pain syndrome relief in osteoarthrosis at conventional administration and ultraphonophoresis of ibuprofen (nurofen gel), we applied ultraphonophoresis of 5% gel nurofen to affected joints of 20 patients of the study group (twice a day with a 5-6 hour interval; the third time the gel was applied locally in the evening). The control group (n = 19) received only local treatment with 5% gel nurofen on the affected joints three times a day. The course of pain syndrome was assessed by the visual analogue scale (VAS). Monitoring of side effects, total blood count, blood biochemistry, urine analysis was made. We recorded significant attenuation of pain by VAS at rest, in palpation, in walking in both the groups. In spite of initial pain intensification in ultraphonophoresis, positive dynamics of pain decline in the study group was more significant. Thus, our study supports anesthetic efficacy of transcutaneous 5% gel nurofen in osteoarthrosis and a rise of this efficacy in combined use of ultrasound and this medicine in ultraphonophoresis.
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Serikov
D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005782:Gels; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D015612:Phonophoresis; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D007052:Ibuprofen