Three ways to make two sides: genetic models of asymmetric nervous system development.
Many anatomical and functional features of nervous systems are asymmetric about the left-right axis. These asymmetries can exhibit either random or invariant laterality at the population level. Recent studies in fish and worms provide insight into the developmental mechanisms used to create both types of asymmetry. These studies reveal diverse and molecularly complex strategies for developing asymmetric nervous systems.
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA. sagasti@mcdb.ucla.edu
Alvaro
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Sagasti
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D004292:Dominance, Cerebral / Q000235:genetics; D007839:Functional Laterality / Q000235:genetics*; D008957:Models, Genetic; D009420:Nervous System / Q000254:growth & development*; D009424:Nervous System Physiological Phenomena; D015027:Zebrafish / Q000502:physiology