Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus.
The aim of this study was to evaluate the association between systemic lupus erythematosus (SLE) and polymorphisms in the interleukin-23 receptor (IL23R) gene, which have been previously found to be associated with two autoimmune diseases: inflammatory bowel disease and psoriasis. Our study includes 224 SLE patients and 342 healthy controls. The genotyping of IL23R variants was carried out using a polymerase chain reaction system with predeveloped TaqMan allelic discrimination assays. No statistically significant differences were observed between SLE patients and healthy controls with any of the IL23R genetic variants. In addition, we did not find any significant differences when we stratified SLE patients according to their clinical and demographic features. These results suggest that IL23R polymorphisms do not appear to play an important role in the susceptibility or severity of SLE in the Spanish population.
Biología Celular e Inmunología, Consejo Superior de Investigaciones Científicas, Technological Park of the Health Sciences, Avenida del Conocimiento s/n, 18100-Armilla, Granada, Spain.
E
E
Sánchez
B
B
Rueda
J L
JL
Callejas
J M
JM
Sabio
N
N
Ortego-Centeno
J
J
Jimenez-Alonso
M A
MA
López-Nevot
J
J
Martín
D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*; D012720:Severity of Illness Index
C515500:IL23R protein, human; D018123:Receptors, Interleukin