Extending the enteric nervous system.
The work reviews the evidence suggesting that lingual components of the autonomic system may be considered the most rostral portion of the enteric nervous system (ENS) defining the concept of lingual ENS (LENS). The LENS is not dissimilar from the more distally located portions of the ENS, however, it is characterized by a massive sensory input generated by collaterals of gustatory and trigeminal fibers. The different neuronal subpopulations that compose the LENS operate reflexes involved in regulation of secretion and vasomotility. Systemic reflexes on the digestive and respiratory apparatus are operated by means of neural connections through the pharynx or larynx. The LENS can modulate the activity of distally located organs by means of the annexed glands.The LENS seems therefore to be a "chemical eye" located at the beginning of the digestive apparatus which analyses the foods before their ingestion and diffuses this information distally. The definition of the LENS supports the concept of an elevated degree of autonomy in the ENS and puts in a new light the role of the gustatory system in modulation of the digestive functions. For its characteristics, the LENS appears to be an ideal model to study the elementary connectivity of the ENS.
Sbarbati
Andrea
A
Department of Morphological and Biomedical Science, Section of Anatomy and Histology, University of Verona, Medical Faculty, Strada Le Grazie 8, 37134, Verona, Italy. andrea.sbarbati@univr.it
Osculati
Francesco
F
D000818:Animals; D004064:Digestive System / Q000294:innervation; D017615:Enteric Nervous System / Q000502:physiology*; D005725:Ganglia, Autonomic / Q000502:physiology*; D017950:Ganglia, Sensory / Q000502:physiology; D006801:Humans; D008036:Lingual Nerve / Q000502:physiology; D009412:Nerve Fibers / Q000502:physiology; D014059:Tongue / Q000294:innervation* / Q000502:physiology