Gingival neurofibroma in a neurofibromatosis type 1 patient.
Neurofibroma is a benign peripheral nerve sheath tumour. It is one of the most frequent tumours of neural origin and its presence is one of the clinical criteria for the diagnosis of type 1 neurofibromatosis (NF-I). Neurofibromatosis type 1 is an autosomal dominantly inherited disease due to an alteration in the long arm of chromosome 17. About 50% of NF-I patients have no family history of the disease. NF-I patients have skin lesions (cafe au lait spots and neurofibromas) as well as bone malformations and central nervous system tumours. Diagnosis is based on a series of clinical criteria. Gingival neurofibroma in NF-I is uncommon. Treatment of neurofibromas is surgical resection. The aim of this paper is to report a case of NF-I with gingival involvement and to review the literature.
García de Marcos
José Antonio
JA
Oral and Maxillofacial Surgery Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. pepio2@hotmail.com
Dean Ferrer
Alicia
A
Alamillos Granados
Francisco
F
Ruiz Masera
Juan José
JJ
García de Marcos
María Jesús
MJ
Vidal Jiménez
Alfredo
A
Valenzuela Salas
Borja
B
García Lainez
Ana
A
D000328:Adult; D005260:Female; D005887:Gingival Neoplasms / Q000473:pathology / Q000601:surgery; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery; D009455:Neurofibroma / Q000473:pathology / Q000601:surgery; D009456:Neurofibromatosis 1