[C-terminal domain (CTD) of the subunit Rpb1 of nuclear RNA polymerase II and its role in the transcription cycle].
The review deals with analysis of the structure, functions and molecular evolution of the CTD (C-terminal domain) of the largest subunit Rpb1 of nuclear RNA polymerase II. All the discovered ways of CTD modifications are summarized. Its interactions with various partners are described in the context of the CTD central role in coupling of the major transcription steps (initiation, elongation and termination) with the main stages of pre-mRNA processing (capping, splicing and polyadenylation) in eukaryotes during different stages of the cell cycle.
M V
MV
Sobennikova
E K
EK
Shematorova
G V
GV
Shpakovskiĭ
D000595:Amino Acid Sequence; D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002843:Chromatin / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D026723:Polyadenylation; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D012319:RNA Polymerase II / Q000502:physiology*; D012322:RNA Precursors / Q000096:biosynthesis; D012323:RNA Processing, Post-Transcriptional; D020449:Repetitive Sequences, Amino Acid; D014158:Transcription, Genetic
D002843:Chromatin; D012322:RNA Precursors; D012319:RNA Polymerase II