Ipomoeassin F, a new cytotoxic macrocyclic glycoresin from the leaves of Ipomoea squamosa from the Suriname rainforest.
A new cytotoxic macrocyclic glycoresin, ipomoeassin F (6), has been isolated from the leaves of Ipomoea squamosa. The structure was elucidated by the interpretation of spectral data. Compound 6 was strongly active in the A2780 (human ovarian cancer cell line) assay with an IC(50) value of 0.036 microM.
Department of Chemistry, Virginia Polytechnic Institute and State University, M/C 0212, Blacksburg, Virginia 24061, USA.
Shugeng
S
Cao
Andrew
A
Norris
Jan H
JH
Wisse
James S
JS
Miller
Randy
R
Evans
David G I
DG
Kingston
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D006001:Glycoconjugates / Q000008:administration & dosage* / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D020128:Inhibitory Concentration 50; D027741:Ipomoea; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D013532:Suriname
D000972:Antineoplastic Agents, Phytogenic; D006001:Glycoconjugates; D010936:Plant Extracts; C523857:ipomoeassin F