Use of silfenadil for treatment of respiratory distress after pneumonectomy for bronchogenic carcinoma.
Post-pneumonectomy respiratory failure is a devastating complication of resection for lung cancer. As proven therapy is limited, we successfully employed a novel medication silfenadil that has been effective in the treatment of pulmonary hypertension.
Thomas
Bradley G
BG
University of Louisville, Louisville, KY, USA.
Maloney
James D
JD
D002283:Carcinoma, Bronchogenic / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D010879:Piperazines / Q000627:therapeutic use*; D011013:Pneumonectomy / Q000009:adverse effects*; D011687:Purines / Q000627:therapeutic use; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D012131:Respiratory Insufficiency / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D016896:Treatment Outcome
D020030:Nitric Oxide Donors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D009569:Nitric Oxide; D000068677:Sildenafil Citrate