Non-choreic movement disorders as initial manifestations of Huntington's disease.
We describe seven patients with genetically confirmed Huntington's disease (HD) who had non-choreic movement disorders as presenting symptoms or signs. Patients with movement disorders other than chorea in the early stages tended to have larger CAG trinucleotide repeat expansion in comparison with more "typical" HD patients.
Becker
Nilson
N
Movement Disorders Unit, Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil.
Munhoz
Renato P
RP
Raskin
Salmo
S
Werneck
Lineu César
LC
Teive
Hélio A G
HA
D000328:Adult; D004421:Dystonia / Q000175:diagnosis / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000175:diagnosis / Q000235:genetics; D016133:Polymerase Chain Reaction; D020323:Tics / Q000175:diagnosis / Q000235:genetics; D014057:Tomography, X-Ray Computed; D019680:Trinucleotide Repeat Expansion / Q000235:genetics*