[Therapeutic effects of hepatic resection in liver metastasis of colorectal cancer].
OBJECTIVE
To evaluate therapeutic effects of hepatic resection in liver metastasis of colorectal cancer (LMCC).


METHODS
The clinical data of 133 cases of LMCC received hepatic resection from January 1, 2000 to December 31, 2005 in Zhongshan Hospital were analyzed retrospectively. The relationship between hepatic resection and survival rate was also concerned.


RESULTS
One hundred and thirty-three cases received curative hepatic resection in all 470 LMCC cases, of which 30 cases from synchronous liver metastasis (SLM) group (totaled 196 cases) and 103 cases from metachronous liver metastasis (MLM) group (totaled 274 cases). Mortality rate during operation was 3.3% in SLM and 1.9% in MLM (P < 0.05). All patients were followed-up till June 31, 2006, the 1, 3, 5 year survival rates and median survival time of SLM were similar to those of MLM, but its recurrence rate was higher (36.7% vs 20.4%, P = 0.030). The 1, 3, 5 year survival rate in the 49 patients who were operable but received non-operation treatment were significantly lower than those in operated patients (P = 0.003). In 30 SLM cases, 22 received I stage resection of their primary and liver metastasis tumor and 8 received liver metastasis resection after the primary surgery (II stage operation), 1, 2, 3 year survival and the median survival time were similar in the two groups. With COX multivariate analysis, incision margin > or = 1 cm (P = 0.036) and reoperation after recurrence (P = 0.041) were protective survival factors, and post-operation recurrence (P = 0.023) was survival risk factor.


CONCLUSIONS
Curative hepatic resection is the first choice of therapy in liver metastasis of colorectal cancer and it can improve survival.
Xu
Jian-Min
JM
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. xujmin@yahoo.com.cn
Zhong
Yun-Shi
YS
Fan
Jia
J
Zhou
Jian
J
Qin
Lun-Xiu
LX
Niu
Wei-Xin
WX
Wei
Ye
Y
Ren
Li
L
Lai
Yan-Han
YH
Zhu
De-Xiang
DX
Qin
Xin-Yu
XY
Wu
Zhao-Han
ZH
D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery*; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D009364:Neoplasm Recurrence, Local; D016019:Survival Analysis; D016896:Treatment Outcome