Potential role of CREB as a prognostic marker in acute myeloid leukemia.
The cAMP response element binding protein (CREB) is a leucine zipper transcription factor that regulates genes responsible for cell proliferation, differentiation and survival. CREB is overexpressed in the bone marrow from most patients with acute leukemia. Overexpression of CREB occurs both at the protein and at the transcript levels and is associated with gene amplification in leukemic blast cells. Higher levels of CREB correlate with a less favorable prognosis in a small cohort of adult patients with acute myeloid leukemia. In one study, patients whose bone marrow over-expresses CREB had an increased risk of relapse and decreased event-free survival. Mice that overexpress CREB in myeloid cells develop a myeloproliferative/myelodysplastic syndrome. These findings suggest that CREB plays an important role in the pathogenesis of acute leukemia and is a potential biomarker of disease.
Jonsson Comprehensive Cancer Center, Division of Hematology/Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, Los Angeles, CA 90095-1781, USA. jerryccheng@gmail.com
Jerry C
JC
Cheng
Samuel
S
Esparza
Salemiz
S
Sandoval
Deepa
D
Shankar
Cecilia
C
Fu
Kathleen M
KM
Sakamoto
D000818:Animals; D014408:Biomarkers, Tumor; D050882:CREB-Binding Protein / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D011379:Prognosis; D011518:Proto-Oncogene Proteins
D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins; D050882:CREB-Binding Protein