Studies of the skin permeation of lipophilic drugs: paclitaxel.
The objective of this investigation was to develop and validate skin permeation methodology for a highly lipophilic drug with respect to sink conditions and intactness of barrier during the course of experiment, using water permeation and trans epidermal water loss as tools.
Khandavilli
S
S
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India.
Panchagnula
R
R
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D015194:Diffusion Chambers, Culture; D000431:Ethanol; D066298:In Vitro Techniques; D008055:Lipids / Q000737:chemistry; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D010539:Permeability; D014677:Pharmaceutical Vehicles; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption; D014870:Water Loss, Insensible
D000972:Antineoplastic Agents, Phytogenic; D008055:Lipids; D014677:Pharmaceutical Vehicles; D000431:Ethanol; D017239:Paclitaxel