Genome-wide scan for serum ghrelin detects linkage on chromosome 1p36 in Hispanic children: results from the Viva La Familia study.
This study was conducted to investigate genetic influence on serum ghrelin and its relationship with adiposity-related phenotypes in Hispanic children (n=1030) from the Viva La Familia study (VFS). Anthropometric measurements and levels of serum ghrelin were estimated and genetic analyses conducted according to standard procedures. Mean age, body mass index (BMI), and serum ghrelin were 11+/-0.13 y, 25+/-0.24 kg/m2 and 38+/-0.5 ng/mL, respectively. Significant heritabilities (p<0.001) were obtained for BMI, weight, fat mass, percent fat, waist circumference, waist-to-height ratio, and ghrelin. Bivariate analyses of ghrelin with adiposity traits showed significant negative genetic correlations (p<0.0001) with weight, BMI, fat mass, percent fat, waist circumference, and waist-to-height ratio. A genome-wide scan for ghrelin detected significant linkage on chromosome 1p36.2 between STR markers D1S2697 and D1S199 (LOD=3.2). The same region on chromosome 1 was the site of linkage for insulin (LOD=3.3), insulinlike growth factor binding protein 1 (IGFBP1) (LOD=3.4), homeostatic model assessment method (HOMA) (LOD=2.9), and C-peptide (LOD=2.0). Several family-based studies have reported linkages for obesity-related phenotypes in the region of 1p36. These results indicate the importance of this region in relation to adiposity in children from the VFS.
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA. svorugan@sfbrgenetics.org
V Saroja
VS
Voruganti
Harald H H
HH
Göring
Vincent P
VP
Diego
Guowen
G
Cai
Nitesh R
NR
Mehta
Karin
K
Haack
Shelley A
SA
Cole
Nancy F
NF
Butte
Anthony G
AG
Comuzzie
D000293:Adolescent; D050218:Body Fat Distribution; D001827:Body Height / Q000235:genetics; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D002648:Child; D002878:Chromosomes, Human, Pair 1; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D054439:Ghrelin; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D009765:Obesity / Q000097:blood / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D010375:Pedigree; D036361:Peptide Hormones / Q000097:blood* / Q000235:genetics; D010641:Phenotype; D040641:Quantitative Trait Loci; D012307:Risk Factors; D013781:Texas
D054439:Ghrelin; D036361:Peptide Hormones