A balance of lipid-sensing mechanisms in the brain and liver.
Recent work has cast a spotlight on the brain as a nutrient-sensing organ that regulates the body's metabolic processes. Here we discuss the physiological and molecular mechanisms of brain lipid sensing and compare these mechanisms to liver lipid sensing. A direct comparison between the lipid-sensing mechanisms in the brain and liver reveals similar biochemical/molecular but opposing physiological mechanisms in operation. We propose that an imbalance between the lipid-sensing mechanisms in the brain and liver may contribute to obesity-associated type 2 diabetes.
Caspi
Liora
L
Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada.
Wang
Penny Y T
PY
Lam
Tony K T
TK
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D023421:Models, Animal; D009765:Obesity / Q000378:metabolism
D007328:Insulin