Maintenance treatment in bipolar disorder: a focus on aripiprazole.
Bipolar disorders (BD) are chronic medical syndromes heterogeneous in phenomenology, pathophysiology and treatment. The longitudinal course of bipolar disorders is often characterized by nonrecovery, subsyndromal symptoms, enduring cognitive deficits and impairment in psychosocial function. The risk for premature mortality from unnatural (e.g., suicide) as well as natural causes (e.g., cardiovascular disease) is significantly higher than the general population. The therapeutic objectives of maintenance therapy are to prevent relapse/recurrence, reduce the risk for premature mortality, promote functional restoration and enhance quality of life. A chronic disease management model, which includes pharmacologic and manual-based psychosocial interventions as paradigmatic components, provides a framework for best practice and optimal patient outcome. This article provides a succinct review of treatments approved by the US FDA for maintenance in bipolar disorders, with a focus on the most recently approved atypical antipsychotic, aripiprazole.
McIntyre
Roger S
RS
University of Toronto, Department of Psychiatry, Department of Pharmacology, Toronto, ON, Canada. roger.mcintyre@uhn.on.ca
Woldeyohannes
Hanna O
HO
Yasgur
Batya S
BS
Soczynska
Joanna K
JK
Miranda
Andrew
A
Konarski
Jakub Z
JZ
D000928:Antidepressive Agents / Q000008:administration & dosage*; D000068180:Aripiprazole; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D010879:Piperazines / Q000008:administration & dosage*; D015363:Quinolones / Q000008:administration & dosage*; D013995:Time
D000928:Antidepressive Agents; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole