Serum Reg-Ialpha is not suitable marker of metabolic syndrome.
BACKGROUND
Reg-1alpha plays a role in various types of tissue regeneration.


OBJECTIVE
To evaluate serum Reg-1alpha for the diagnosis of metabolic syndrome.


METHODS
14 non-obese, healthy subjects and 15 individuals with metabolic syndrome were studied. Anthropometric and laboratory analysis in sera (Body Mass Index--BMI, insulin, triglycerides, cholesterol, HDL-cholesterol, LDL-cholesterol, uric acid, aglucose, Quicki calculation, Reg-1alpha) were performed.


RESULTS
Reg-1alpha levels did not differ between subjects with metabolic syndrome and healthy subjects (means 597.7 vs. 631.1 ng/l, p < 0.01) and positively correlated only with fasting glucose (r = 0.34; p < 0.01) and age (r = 0.38; p < 0.01); Reg-1alpha correlated even after adjustment to age. Reg-lalpha concentrations did not differ in men and women.


CONCLUSIONS
Our study, for the first time, indicates that serum Reg-1alpha is not useful for the diagnosis of metabolic syndrome (Tab. 3, Ref. 7).
Department of Laboratory Medicine and Metabolic and Diabetes Outpatient Centre, Sternberk Hospital, Czech Republic. david.stejskal@quick.cz
D
D
Stejskal
M
M
Karpisek
D
D
Horakova
L
L
Cizek
G
G
Janoutova
V
V
Janout
D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D051847:Lithostathine / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis*
D015415:Biomarkers; D051847:Lithostathine; C497617:REG1A protein, human