Application of scaffold materials in tissue reconstruction in immunocompetent mammals: our experience and future requirements.
In spite of many researches on scaffold material design, fabrication and characterization, as well as cell-material interaction in vitro, in vivo study especially in large mammals should be an essential step towards practical application. In our center, different scaffold materials have been applied to the reconstruction of various types of tissues using immunocompetent mammals as major animal models, such as for reconstruction of bone, cartilage, tendon, skin, blood vessel and corneal stroma, etc. In this article, our experience, as well as encountered challenges in the application of scaffold materials, is introduced. Additionally, future requirements for scaffold application in tissue reconstruction and regeneration are proposed as well.
Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, National Tissue Engineering Center of China, 639 Zhi Zao Ju Road, Shanghai 200011, PR China.
Wei
W
Liu
Yilin
Y
Cao
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001698:Biomedical Engineering / Q000295:instrumentation* / Q000379:methods; D005109:Extracellular Matrix / Q000378:metabolism; D048091:Guided Tissue Regeneration; D006801:Humans; D007107:Immune System; D008322:Mammals; D019651:Plastic Surgery Procedures; D012038:Regeneration; D044968:Regenerative Medicine / Q000295:instrumentation* / Q000379:methods; D012886:Skull / Q000000981:diagnostic imaging; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods; D014057:Tomography, X-Ray Computed
D001672:Biocompatible Materials