Detection of pemphigus autoantibodies in healthy relatives of Turkish patients with pemphigus.
BACKGROUND
Pemphigus autoantibodies have been reported in healthy relatives of pemphigus patients suggesting a genetic predisposition in the pathogenesis of the disease.


OBJECTIVE
To test for the presence of pemphigus autoantibodies in healthy relatives of Turkish patients of pemphigus.


METHODS
The study group comprised 45 pemphigus patients, 75 unaffected family members and 47 healthy individuals in the control group. Direct and indirect immunofluorescence techniques were performed to determine the presence of pemphigus autoantibodies.


RESULTS
By indirect immunofluorescence staining, circulating pemphigus autoantibodies were found in 26.7% of the relatives and in only two of the controls (P value = 0.0001). A direct immunofluorescence technique revealed positive results in three (4%) of the relatives and none of the controls.


CONCLUSIONS
The presence of pemphigus autoantibodies in clinically healthy relatives indicates that genetic predisposition is necessary but not sufficient for the development of clinical disease.
Kavala
Mukaddes
M
Department of Dermatology, Göztepe Training and Research Hospital, Istanbul, Turkey.
Kocaturk
Ozgur Emek
OE
Demirkesen
Cuyan
C
Can
Burce
B
Zindanci
Ilkin
I
Turkoglu
Zafer
Z
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001706:Biopsy; D005260:Female; D005455:Fluorescent Antibody Technique; D020022:Genetic Predisposition to Disease; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000235:genetics / Q000276:immunology*; D012867:Skin / Q000276:immunology; D014421:Turkey
D001323:Autoantibodies; D007074:Immunoglobulin G