[Influence of thyroliberin on vasopressin and oxytocin release from the hypothalamo-neurohypophysial system under in vivo and in vitro conditions].
A thorough presentation of the influence of thyroliberin (TRH) on vasopressin and oxytocin release from the hypothalamo-neurohypophysial system is presented. Thyroliberin affects in different ways both neurohormone secretion in females during lactation according to the water-electrolyte metabolism in the course of the circadian rhythm of vasopressin and oxytocin release as well as during in vitro incubation of isolated neurointermediate lobe or hypothalamo-neurohypohysial explants. The results showed that: TRH acts as a stimulator of oxytocin release into the blood by equilibrated water-electrolyte metabolism, TRH acts in the central nervous system as an inhibitory neuromodulator of vasopressin and oxytocin release from the hypothalamo-neurohypophysial system under in vitro conditions, by osmotic stimulation, as well as in females during lactation, TRH inhibits AVP release in acute bleeding-provoked hypovolemia and alters the circadian rhythm of vasopressin and oxytocin release. It is assumed that this neuropeptide can interact with the mechanisms engaged in vasopressin and oxytocin release and can disturb these mechanisms, especially under conditions of augmented demand of the organism for these neurohormones.
Zakład Badań Neuropeptydów, Katedra Patologii Ogólnej i Doświadczalnej, Uniwersytet Medyczny w Łodzi. joannack@poczta.onet.pl
Joanna
J
Ciosek
D000818:Animals; D003681:Dehydration / Q000378:metabolism; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D007774:Lactation / Q000378:metabolism; D008297:Male; D010121:Oxytocin / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism*; D014867:Water / Q000378:metabolism; D014868:Water Deprivation
D014867:Water; D014667:Vasopressins; D010121:Oxytocin; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine