Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcome.
We analyzed the factors and outcome of patients with disseminated adenovirus infection (dAdV) after allogeneic hematopoeitic stem cell transplantation (HSCT). Thirty patients with dAdV were identified among 620 allogeneic HSCT recipients. Primary diseases were leukemia (n=17), Fanconi anemia (n=12) or others (n=1). Source of stem cells was unrelated in 28 and related in 2 patients. The graft consisted of peripheral blood (n=3), bone marrow (n=12) and unrelated cord-blood (UCB, n=15). Risk factors for dAdV in unrelated HSCT recipients were previous Fanconi disease (p=0.03) and GVHD (p=0.02) in children, and cord blood source of stem cells (p=0.029) and GVHD (0.024) in adults.
Service d'Hématologie, Greffe, Paris, France.
Marie
M
Robin
Stéphanie
S
Marque-Juillet
Catherine
C
Scieux
Régis
R
Peffault de Latour
Christèle
C
Ferry
Vanderson
V
Rocha
Jean-Michel
JM
Molina
Anne
A
Bergeron
Agnès
A
Devergie
Eliane
E
Gluckman
Patricia
P
Ribaud
Gérard
G
Socié
D000256:Adenoviridae / Q000235:genetics*; D000258:Adenovirus Infections, Human / Q000209:etiology* / Q000628:therapy / Q000821:virology; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome