Metal-mediated peptide assembly: use of metal coordination to change the oligomerization state of an alpha-helical coiled-coil.
Metal coordination is used to alter the oligomerization state of a designed peptide structure. The 30-residue polypeptide AQ-Pal14Pal21contains two metal-binding 4-pyridylalanine (Pal) residues on its solvent-exposed surface and exists as a very stable two-stranded alpha-helical coiled-coil. Upon the addition of Pt(en)(NO3)2, a significant conformational change to a metal-bridged, four-helix bundle is seen.
Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.
Mikhail V
MV
Tsurkan
Michael Y
MY
Ogawa
D000409:Alanine / Q000031:analogs & derivatives*; D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D017433:Protein Structure, Secondary; D011725:Pyridines / Q000737:chemistry*
D010455:Peptides; D011725:Pyridines; D010984:Platinum; C023666:pyridine; D000409:Alanine