Iodocyclization reactions for the desymmetrization of cyclohexa-1,4-dienes.
Fifteen examples are presented showing that various modes of cyclization (5-endo, 5-exo, 6-endo, 6-exo, and 7-endo) can be used for the desymmetrization of cyclohexa-1,4-dienes. All take place with complete diastereocontrol and good yield.
Butters
M
M
School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK.
Elliott
M C
MC
Hill-Cousins
J
J
Paine
J S
JS
Walker
J K E
JK
D003500:Cyclization; D053138:Cyclohexenes / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D053138:Cyclohexenes; C048401:1,4-cyclohexadiene; D007455:Iodine