Antioxidative effect of rhizome of Zinziber officinale on paraben induced lipid peroxidation: an in vitro study.
Antioxidative effect of aqueous extract of rhizome of Ginger (Zinziber officinale) was examined on p-hydroxybenzoic acid (paraben) induced lipid peroxidation. Addition of paraben (25-150 microg/mL) to liver and kidney homogenates significantly increases H2O2 induced lipid peroxidation in vitro. Effect was dose dependent up to 100 microg/mL concentration. An addition of aqueous extract of ginger significantly reduced paraben (100 microg/mL) induced lipid peroxidation in liver and kidney homogenates. The effect was concentration dependent.
Asnani
Veena
V
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad 380009, India.
Verma
Ramtej Jayram
RJ
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D020939:Zingiber officinale / Q000737:chemistry*; D006861:Hydrogen Peroxide; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D010226:Parabens / Q000008:administration & dosage / Q000633:toxicity; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D027343:Rhizome
D000975:Antioxidants; D010226:Parabens; D010936:Plant Extracts; D006861:Hydrogen Peroxide; C038193:4-hydroxybenzoic acid