Molecular chaperones and neurodegenerative diseases.
Neurodegenerative diseases are characterized by the accumulation of intracellular or extracellular protein aggregates that result from conformational changes in proteins. These diseases may result from an imbalance between the production of misfolded proteins and normal chaperone capacity. Molecular chaperones provide a first line of defence against misfolded, aggregation-prone proteins and are, therefore, promising therapeutic targets for neurodegenerative diseases.
Department of Pharmacology, Medical College, Wuhan University, Wuhan 430071, China; Institute of Basic Medical Science, Academy of Military Medical Science, Beijing 100850, China; E-mail: fanming@nic.bmi.ac.cn.
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Yan
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Wang
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Fan