[R1 resection in the surgery of upper gastrointestinal tumors: relevance and therapeutic consequences].
Microscopically involved tumor margins are an important problem in the surgery of locally advanced esophageal and gastric carcinomas. We conducted a systematic review of the literature and a specific analysis of our own patient database. This article summarizes current knowledge of the incidence and prognosis of R1 resections in upper gastrointestinal cancers. Preoperative strategies for reducing the rate of R1 resections are presented, and the surgical options in case of R1 resection are discussed.
Nationales Centrum für Tumorerkrankungen (NCT), Universitätsklinikum, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany. florian.lordick@med.uni-heidelberg.de
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Lordick
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Ott
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Novotny
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Schuhmacher
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Siewert
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D019160:Endosonography; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D004947:Esophagus / Q000473:pathology; D005743:Gastrectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D015337:Multicenter Studies as Topic; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013997:Time Factors