RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes.
Toxin/antitoxin (TA) systems, viewed as essential regulators of growth arrest and programmed cell death, are widespread among prokaryotes, but remain sparsely annotated. We present RASTA-Bacteria, an automated method allowing quick and reliable identification of TA loci in sequenced prokaryotic genomes, whether they are annotated open reading frames or not. The tool successfully confirmed all reported TA systems, and spotted new putative loci upon screening of sequenced genomes. RASTA-Bacteria is publicly available at http://genoweb.univ-rennes1.fr/duals/RASTA-Bacteria.
Sevin
Emeric W
EW
CNRS UMR6061 Génétique et Développement, Université de Rennes 1, IFR 140, Av, du Prof, Léon Bernard, CS 34317, 35043 Rennes, France. esevin@univ-rennes1.fr
Barloy-Hubler
Frédérique
F
D000465:Algorithms; D000595:Amino Acid Sequence; D000992:Antitoxins / Q000737:chemistry* / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics; D019295:Computational Biology / Q000379:methods*; D017124:Conserved Sequence; D030541:Databases, Genetic; D016680:Genome, Bacterial; D020407:Internet; D016366:Open Reading Frames; D020539:Sequence Analysis, Protein / Q000379:methods*; D016962:Sinorhizobium meliloti / Q000235:genetics; D012984:Software; D014118:Toxins, Biological / Q000737:chemistry* / Q000235:genetics
D000992:Antitoxins; D001426:Bacterial Proteins; D014118:Toxins, Biological