Decreased Tc-99m sestamibi uptake in a sternal brown tumor indicating response to anti metabolic therapy for secondary hyperparathyroidism.
Brown tumors are rare but serious complications of renal osteodystrophy, and can be treated by parathyroidectomy or by pharmacological treatment of hyperparathyroidism. In addition to parathyroid lesions such as adenoma, hyperplasia, and carcinoma, brown tumors have been detected effectively by using dual phase Tc-99m sestamibi and Tl-201 chloride. We describe an unusual case of brown tumor at the manibrium sterni which shows marked increased Tc-99m sestamibi uptake on the initial scan, with decreasing tracer activity on follow-up scan indicating a response to antimetabolic therapy.
Department of Nuclear Medicine, Ankara University Medical Faculty, Ankara, Turkey.
Elgin
E
Ozkan
Nuri
N
Arslan
Atilla
A
Arslanoglu
Alper Ozgur
AO
Karacalioglu
D000328:Adult; D018286:Carcinoma, Giant Cell / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013249:Sternum / Q000000981:diagnostic imaging / Q000378:metabolism; D017256:Technetium Tc 99m Sestamibi / Q000493:pharmacokinetics; D014807:Vitamin D / Q000008:administration & dosage*
D019275:Radiopharmaceuticals; D014807:Vitamin D; D017256:Technetium Tc 99m Sestamibi