[Glucocorticoid induced osteoporosis].
Secondary osteoporosis is caused by various non-physiological factors. It affects 5% of all patients with osteoporosis and accounts for 20% of all osteoporotic fractures. Glucocorticoid induced osteoporosis is the most common form of secondary osteoporosis, whereas an endogenous Cushing syndrome rarely results in decreased bone mineral density. In addition, chronic inflammatory diseases which require a glucocorticoid therapy also need to be considered in the context of osteoporosis. This article presents the current data on glucocorticoid induced osteoporosis and an update of the proposed DVO (Dachverbandes Osteologie, umbrella organization of German scientific osteology-related societies) guidelines 2006.
Lange
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Abt. Rheumatologie, Klinische Immunologie, Physikalische Medizin und Osteologie, Kerckhoff-Klinik, Bad Nauheim. U.Lange@kerckhoff-klinik.de
Müller-Ladner
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D015519:Bone Density / Q000187:drug effects; D002118:Calcium / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D005598:Fractures, Spontaneous / Q000139:chemically induced; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008134:Long-Term Care; D010024:Osteoporosis / Q000139:chemically induced* / Q000188:drug therapy; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D016103:Spinal Fractures / Q000139:chemically induced; D014807:Vitamin D / Q000627:therapeutic use
D004164:Diphosphonates; D005938:Glucocorticoids; D014807:Vitamin D; D002118:Calcium