Adult stem cells: perspectives for therapeutic applications.
The use of adult stem cells in tissue regeneration appears to be a powerful research tool, due to the intrinsic characteristics of these cells, i.e., self-renewal and unlimited capacity for proliferation. In particular, mesenchymal stem cells (MSCs) obtained from bone marrow or peripheral blood can be easily isolated, cultivated, propagated and can be differentiated into several specialized cell types thanks to their plasticity. Among these cells, MSCs can evolve into cardiac cell lineages. Since heart damage leads to the irreversible loss of cardiac function, cell transplantation could be a potential therapy for heart injury. Our laboratory has focused on the purification and expansion of rat and sheep MSCs, their differentiation into cardiomyocytes and their characterisation. Numerous results indicate that MSCs could be promising for therapy, however we need to better understand the biology of stem cells to improve methods for delivery and/or pharmacological activation. These techniques can indeed track engrafted cells and systems to guarantee their safe use.
Ferrari
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Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Via A. Bianchi, 7, 25124, Brescia, Italy. mferrari@bs.izs.it
Corradi
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Lazzaretti
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De'Cillà
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Losi
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Villa
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Lanfranchi
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D053687:Adult Stem Cells / Q000166:cytology* / Q000502:physiology*; D000818:Animals; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D005434:Flow Cytometry; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000662:veterinary*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051381:Rats; D012756:Sheep