T-cell co-stimulatory molecules: novel targets for the treatment of allergic airway disease.
The first two articles in this series discussed the fundamental concept of T-cell co-stimulation as a key event in the induction of any immune response, in addition to reviewing the current data on the role of co-stimulatory molecules for the induction and progression of allergic airway diseases. Based on these considerations, this final edition will delineate and discuss novel strategies for the prevention and/or therapy of allergic diseases based upon the modulation of co-stimulation.
Dept of Paediatric Pneumology and Immunology, Charité Medical University of Berlin, Berlin, Germany.
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D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D015703:Antigens, CD / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D001249:Asthma / Q000276:immunology* / Q000628:therapy*; D016535:Bronchial Hyperreactivity; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D060889:Inducible T-Cell Co-Stimulator Protein; D007249:Inflammation; D008024:Ligands; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D023421:Models, Animal; D008954:Models, Biological; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D016207:Cytokines; C556692:ICOS protein, human; C556694:Icos protein, mouse; D060889:Inducible T-Cell Co-Stimulator Protein; D008024:Ligands