The role of dendritic cells in the immunopathogenesis of psoriasis.
Psoriasis vulgaris is a chronic inflammatory skin disease that is marked by a complex interplay of dendritic cells (DCs), T-cells, cytokines, and downstream transcription factors as part of a self-sustaining type 1 cytokine network. As integral players of the immune system, DCs represent antigen-presenting cells that are crucial for efficient activation of T-cells and B-cells. DCs have also been linked to distinct chronic inflammatory conditions, including psoriasis. In the setting of psoriasis therapy, DC/T cell interactions serve as a potential target for biologic response modifiers. Here we describe the major DC subsets as well as the immunologic involvement of DCs within the context of psoriatic lesions.
Jariwala
Sunit P
SP
Department of Internal Medicine, Albert Einstein/Montefiore Medical Center, 33 Teal Court, East Windsor, NJ 08520, USA. sjariwal@montefiore.org
D002450:Cell Communication / Q000276:immunology; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology* / Q000473:pathology*; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology