[Number of lymph node metastases: a significant prognostic factor for patients with radical resection of carcinoma of the ampulla of Vater].
OBJECTIVE
To identify prognostic factors predicting survival after radical resection of ampullary carcinoma.


METHODS
Clinical data of sixty- five patients with cancer of the ampulla of Vater underwent pancreaticoduodenectomy and regional lymphadenectomy were analyzed retrospectively.


RESULTS
A total of 1380 lymph nodes dissected from the resected specimens was examined to detect the presence of metastasis. The median follow- up period was 83 months. Univariate analysis revealed that factors associated with poor survival included the number and the location of positive nodes. Thirty- three of the 65 patients had a total of 116 positive lymph nodes, of whom 20 had 1- 3 positive regional nodes lymph and 13 had > or = 4 positive regional lymph nodes. Multivariate analysis revealed that the number of positive nodes lymph was an independent prognostic factor (P=0.007), while the locations of lymph nodes failed to remain as an independent variable. The survival rate in patients with > or = 4 positive lymph nodes was significantly lower than that in those with 1- 3 positive lymph nodes. The median survival time was 49 months with a 5- year survival rate of 43% in patients with 1- 3 positive lymph nodes, whereas all patients with > or = 4 positive nodes died of the disease within 23 months after resection (P=0.0001).


CONCLUSIONS
The number of positive regional lymph nodes is an independent prognostic factor in patients with ampullary carcinoma after resection.
Department of Gastrointestinal Surgery, Affiliated Cancer Hospital, Tianjin Medical University, Tianjin 300060, China. liuning001@sina.com
Ning
N
Liu
Han
H
Liang
Ru-peng
RP
Zhang
Yuan
Y
Pan
Yong
Y
Liu
Jing-yu
JY
Deng
Xiao-na
XN
Wang
Xue-wei
XW
Ding
Xi-shan
XS
Hao
D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology; D003138:Common Bile Duct Neoplasms / Q000473:pathology*; D004379:Duodenal Neoplasms / Q000175:diagnosis* / Q000556:secondary; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011184:Postoperative Period; D011379:Prognosis; D012189:Retrospective Studies