MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus.
MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88(-/-) mice. We found an increased susceptibility to VSV in myd88(-/-) mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88(-/-) mice correlated with impaired recruitment of immune cells to the site of infection. In the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis.
Lang
Karl S
KS
Institutes of Experimental Immunology, Neuropathology and Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland. karl.lang@usz.ch
Navarini
Alexander A
AA
Recher
Mike
M
Lang
Philipp A
PA
Heikenwalder
Mathias
M
Stecher
Barbara
B
Bergthaler
Andreas
A
Odermatt
Bernhard
B
Akira
Shizuo
S
Honda
Kenya
K
Hengartner
Hans
H
Zinkernagel
Rolf M
RM
D000818:Animals; D000906:Antibodies / Q000276:immunology; D002460:Cell Line; D018925:Chemokines / Q000378:metabolism; D006224:Cricetinae; D018792:Encephalitis, Viral / Q000276:immunology / Q000378:metabolism* / Q000473:pathology* / Q000821:virology; D007370:Interferon Type I / Q000378:metabolism; D007375:Interleukin-1 / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D053594:Myeloid Differentiation Factor 88 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D015996:Survival Rate; D014721:Vesicular stomatitis Indiana virus / Q000502:physiology*
D000906:Antibodies; D018925:Chemokines; D007370:Interferon Type I; D007375:Interleukin-1; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88