Potential of a simplified p24 assay for early diagnosis of infant human immunodeficiency virus type 1 infection in Haiti.
With global efforts to scale up the prevention of mother-to-child transmission services and pediatric antiretroviral therapy, there is an urgent need to introduce a simple, low-cost infant human immunodeficiency virus test in the field. We postulated that the p24 antigen capture enzyme-linked immunosorbent assay could be simplified by eliminating signal amplification without compromising diagnostic accuracy.
George
Erik
E
Department of Medicine, Weill Medical College, Cornell University, New York, NY, USA. erikgeorge@yepmail.net
Beauharnais
Carole Anne
CA
Brignoli
Emilio
E
Noel
Francine
F
Bois
Gyrlande
G
De Matteis Rouzier
Patricia
P
Altenor
Martine
M
Lauture
Daniel
D
Hosty
Marlène
M
Mehta
Sapna
S
Wright
Peter F
PF
Pape
Jean W
JW
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis*; D042241:Early Diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D016655:HIV Core Protein p24 / Q000032:analysis*; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D012367:RNA, Viral / Q000097:blood; D012680:Sensitivity and Specificity
D016655:HIV Core Protein p24; D012367:RNA, Viral