Stem cells in prostate cancer initiation and progression.
Peter Nowell and David Hungerford's discovery of the Philadelphia chromosome facilitated many critical studies that have led to a paradigm shift in our understanding of cancer as a disease of stem cells. This Review focuses on the application of these concepts to investigation of the role of stem cells in prostate cancer initiation and progression. Major strides in the development of in vitro and in vivo assays have enabled identification and characterization of prostate stem cells as well as functional evaluation of the tumorigenic effects of prostate cancer-related genetic alterations.
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA.
Devon A
DA
Lawson
Owen N
ON
Witte
D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008297:Male; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D010677:Philadelphia Chromosome; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology