[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy].
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin. Some authors have pointed out an increased risk of TEN/SJS when phenytoin is associated with whole brain radiotherapy. We report a patient diagnosed with breast adenocarcinoma and brain metastases that was on treatment with phenytoin and, shortly after receiving whole brain radiotherapy, developed toxic epidermal necrolysis.
Servicio de Medicina Interna, Hospital La Moraleja-Sanitas, Alcobendas, Madrid, España.
F A
FA
Fernández
E
E
Pintor
R
R
Quesada
F J
FJ
Garcés
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000556:secondary; D001943:Breast Neoplasms / Q000601:surgery; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D015409:Mastectomy, Radical; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000209:etiology*
D000927:Anticonvulsants; D010672:Phenytoin; D003907:Dexamethasone; D009853:Omeprazole