[A method for calculating the additional quantity of protamine sulfate during cardiosurgical operations].
The paper describes a method for calculating the additional dose of protamine sulfate solution during incomplete heparin neutralization after cardiac surgery under extracorporeal circulation, by estimating the anti-Xa-activity of venous blood plasma. The method may be an alternative to the use of devices to measure the blood concentration of free heparin, such as a "Hepcon" apparatus.
Charnaia
M A
MA
Morozov
Iu A
IuA
Gladysheva
V G
VG
D001777:Blood Coagulation; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D001026:Coronary Artery Bypass / Q000009:adverse effects; D005112:Extracorporeal Circulation / Q000379:methods; D015951:Factor Xa / Q000032:analysis; D065427:Factor Xa Inhibitors; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006493:Heparin / Q000097:blood*; D006494:Heparin Antagonists / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D011479:Protamines / Q000008:administration & dosage*; D012214:Rheumatic Heart Disease / Q000601:surgery
D065427:Factor Xa Inhibitors; D006494:Heparin Antagonists; D011479:Protamines; D006493:Heparin; D015951:Factor Xa