Leptin protects vital organ functions after sepsis through recovering tissue myeloperoxidase activity: an anti-inflammatory role resonating with indomethacin.
In this research, the role of leptin on sepsis-induced organ dysfunction was evaluated. Making use of a mice sepsis model, changes of alanine transaminase and uric acid in serum, myeloperoxidase activity, leptin levels and histological alterations in heart, lung, liver and kidney were determined. Results showed that sepsis induced significantly higher levels of serum alanine transaminase and uric acid, decreased tissue myeloperoxidase activity and leptin levels, and triggered distinct histological alterations. However, leptin and indomethacin injections reversed those impairments at 6h and/or 12h after injury. These data reveal a protective role of both leptin and indomethacin on vital organ functions after sepsis by recovering tissue myeloperoxidase activity.
Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of P.L.A., 28 Fuxing Road, Beijing 100853, PR China.
Ji
J
Lin
Guang-Tao
GT
Yan
Hui
H
Xue
Xiu-Hua
XH
Hao
Kai
K
Zhang
Lu-Huan
LH
Wang
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D020738:Leptin / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008168:Lung / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D015213:Neuroimmunomodulation; D009195:Peroxidase / Q000378:metabolism*; D018805:Sepsis / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D014527:Uric Acid / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D020738:Leptin; D014527:Uric Acid; D009195:Peroxidase; D000410:Alanine Transaminase; D007213:Indomethacin