Aldose reductase and advanced glycation endproducts inhibitory effect of Phyllostachys nigra.
To evaluate active principles for diabetic complications from the black bamboo leaves, Phyllostachys nigra, eight compounds were isolated and tested for their effects on rat lens aldose reductase and advanced glycation endproducts. As a result, luteolin 6-C-(6''-O-trans-caffeoylglucoside) was found to show a strong aldose reductase and advanced glycation endproducts inhibition. This compound showed antioxidative activity measured in Photochem apparatus. It is concluded, therefore, that luteolin 6-C-(6''-O-trans-caffeoylglucoside) (6), a flavone of this plant, have antioxidative as well as aldose reductase and advanced glycation endproducts inhibitory effects. As a result, this compound could be offered as a leading compound for further study as a new natural products drug for diabetic complications.
Jung
Sang Hoon
SH
Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung 210-340, Korea.
Lee
Jung Min
JM
Lee
Hee Ju
HJ
Kim
Chul Young
CY
Lee
Eun Ha
EH
Um
Byung Hun
BH
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D002109:Caffeic Acids / Q000737:chemistry* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D007908:Lens, Crystalline / Q000201:enzymology; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000975:Antioxidants; D002109:Caffeic Acids; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D005960:Glucosides; D017127:Glycation End Products, Advanced; D010936:Plant Extracts; C522790:luteolin 6-C-(6''-O-trans-caffeoylglucoside); D000449:Aldehyde Reductase; D005947:Glucose