Fatal lactic acidosis and hypoglycemia in a patient with relapsed natural killer/T-cell lymphoma.
Presented here is the first reported case of natural killer (NK)/T-cell lymphoma associated with lactic acidosis (LA) and hypoglycemia. LA and hypoglycemia are rare complications of non-Hodgkin's lymphoma. A 28-year-old male patient with NK/T-cell lymphoma had a relapse after 14 mo of initial remission and was admitted to the hospital because of altered mental status. He developed severe LA (pH, 7.17; lactate, 11.2 mmol/L) and hypoglycemia (42 mg/dL) that was resistant to sodium bicarbonate and glucose infusions. A very brief partial remission was achieved after a cycle of vincristine, dexamethasone, and L-asparaginase was given, but the disease recurred quickly after chemotherapy was discontinued and the patient did not respond to additional chemotherapy. The patient expired at 47 d after relapse. An extensive review of the literature reveals that only 2 of 28 patients have achieved complete remission, and more than 75% of patients died within 1 mo. Furthermore, 90% of previously reported cases had liver involvement. The case described here indicates that non-Hodgkin's lymphoma-induced LA portends a poor prognosis.
He
Yi-Fu
YF
Department of Medical Oncology, The Provincial Hospital, Affiliated with Anhui Medical University at Hefei, China.
Wei
Wei
W
Sun
Zi-Min
ZM
Ji
Chu-Shu
CS
Wang
Gang
G
Chen
Man-Ping
MP
Hu
Chang-Lu
CL
Hu
Bing
B
D000140:Acidosis, Lactic / Q000209:etiology*; D000328:Adult; D017809:Fatal Outcome; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007694:Killer Cells, Natural; D016399:Lymphoma, T-Cell / Q000150:complications*; D008297:Male; D009669:Nose Neoplasms / Q000150:complications*