A novel ketolide class: Synthesis and antibacterial activity of a lead compound.
Synthesis and antibacterial activity of a new class of ketolide antibiotics, exemplified by the prototype GW680788X (1), are described. The structure of (1) has been elucidated by spectroscopic analysis. The good antibacterial activity shown by (1) in comparison with clarithromycin prompted us to consider this compound as a lead molecule for further exploration.
Andreotti
Daniele
D
GlaxoSmithKline, Medicine Research Centre, Via A Fleming 4, I-37135 Verona, Italy. daniele.g.andreotti@gsk.com
Bientinesi
Ilaria
I
Biondi
Stefano
S
Donati
Daniele
D
Erbetti
Isabelle
I
Lociuro
Sergio
S
Marchioro
Carla
C
Pozzan
Alfonso
A
Ratti
Emiliangelo
E
Terreni
Silvia
S
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D048628:Ketolides / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular
D000900:Anti-Bacterial Agents; D048628:Ketolides