Oxaliplatin-induced immune hemolytic anemia: a case report and review of the literature.
We report a 59-year-old woman diagnosed with metastasic colorectal cancer who developed immune hemolytic anemia during FOLFOX chemotherapy (oxaliplatin/leucovorin/5-fluorouracil). Immunohematologic studies demonstrated that immune hemolysis was oxaliplatin-mediated. On the basis of this case and in a review of the literature in which 13 cases of previously reported oxaliplatin-induced immune cytopenia have been identified, we suggest some clinical clues regarding the use of oxaliplatin in cancer patients.
Cobo
Francesc
F
Oncohematology Unit, Hospital Ntra. Sra. De Meritxell, Escaldes-Engordany, Andorra. fcobo.bcn@quiron.es
De Celis
Guillem
G
Pereira
Arturo
A
Latorre
Xavier
X
Pujadas
Jaume
J
Albiol
Santiago
S
D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D000931:Antidotes / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis; D015179:Colorectal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008206:Lymphatic Diseases / Q000473:pathology; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000077150:Oxaliplatin; D010976:Platelet Count
D000931:Antidotes; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D001323:Autoantibodies; D006454:Hemoglobins; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil