Glomerular arginine transport is attenuated in chronic renal failure in rats.
L-Arginine supplementation was found to have a reno-protective effect in different models of chronic renal failure (CRF) in spite of normal plasma levels. Experiments were designed to determine if changes in glomerular uptake of arginine occur in 5/6 nephrectomized rats as a model of CRF. Renal function and glomerular uptake of radiolabeled arginine {[3H] L-arginine} was measured in sham operated, 5/6 nephrectomy, and right nephrectomy rats. Renal failure and proteinuria was found in the CRF animals only. Arginine uptake by glomeruli harvested from rats with CRF was significantly lower than that by glomeruli from sham operated and unilateral nephrectomy rats.


CONCLUSIONS
glomerular arginine uptake is decreased in CRF. This phenomenon can explain the beneficial effect of L-arginine supplementation in CRF.
Nephrology Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. nmdri@netvision.net.il
Doron
D
Schwartz
Yonatan
Y
Ozery
Idit F
IF
Schwartz
Yoram
Y
Wollman
Tamara
T
Chernichovsky
Miriam
M
Blum
Adrian
A
Iaina
D000818:Animals; D001120:Arginine / Q000378:metabolism*; D001692:Biological Transport; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000601:surgery; D008297:Male; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar
D001120:Arginine