Pediatric keratoplasty in India: indications and outcomes.
OBJECTIVE
To analyze the indications and outcomes of pediatric corneal transplantation surgery in a tertiary eye care center in the developing world.


METHODS
In this longitudinal, retrospective study involving continuous cases, the records of 168 eyes of 154 children undergoing keratoplasty at a tertiary care center's specialized keratoplasty clinic during a 7-year period (1998-2004) were reviewed. The demography, etiology of opacification, visual acuity, and other findings were recorded. Intraoperative and postoperative details were reviewed. Major postoperative outcomes analyzed were visual acuity, graft survival, causes of graft failure, and follow-up duration.


RESULTS
Infectious keratitis (43%) was the most common indication for keratoplasty, followed by congenital glaucoma (16.6%) and corneal trauma (11.2%). Overall 77% graft survival was seen at 36 months, and better graft outcome was associated with younger age and longer regular follow-up. Postoperatively, a best-corrected visual acuity (BCVA) > 20/200 could be achieved in only 30.1% of eyes at the last follow-up. Graft failure was seen in 18.4% of eyes, with graft infection being the most frequent cause (50%). Moreover, graft infection was the most common cause of graft failure in all age groups.


CONCLUSIONS
In the developing world, infectious keratitis is the most common indication for pediatric keratoplasty and the most frequent cause of its failure.
Cornea and Refractive Surgery Services, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Namrata
N
Sharma
Gaurav
G
Prakash
Jeewan S
JS
Titiyal
Radhika
R
Tandon
Rasik B
RB
Vajpayee
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003316:Corneal Diseases / Q000453:epidemiology* / Q000601:surgery; D003906:Developing Countries; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D015948:Keratoplasty, Penetrating / Q000706:statistics & numerical data*; D008297:Male; D010349:Patient Compliance; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity