Zn-proline catalyzed selective synthesis of 1,2-disubstituted benzimidazoles in water.
Zn-proline (5 mol%) performs as a novel water-soluble and recyclable Lewis acid catalyst for the selective synthesis of 1,2-disubstituted benzimidazoles from wide range of substituted o-phenylenediamines and aldehydes in moderate to excellent isolated yields (42-92%) using water as solvent at ambient temperature.
Ravi
Varala
V
Indian Institute of Chemical Technology, Hyderabad, India.
Ramu
Enugala
E
Vijay
Kotra
K
Rao
Adapa Srinivas
AS
D001547:Benzaldehydes / Q000737:chemistry; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000737:chemistry*; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D014867:Water / Q000737:chemistry; D009764:o-Phthalaldehyde / Q000737:chemistry
D001547:Benzaldehydes; D001562:Benzimidazoles; D007202:Indicators and Reagents; D009942:Organometallic Compounds; C522676:Zn-proline; D014867:Water; D009764:o-Phthalaldehyde; D011392:Proline