Loss of pregnancy-associated plasma protein A extends lifespan in mice.
Genetic deletion in mice of pregnancy-associated plasma protein A (PAPP-A), a recently identified metalloproteinase in the insulin-like growth factor system, extends by 30-40% both mean and maximum lifespan with no reduction in food intake or secondary endocrine abnormalities. Furthermore, these mice have markedly reduced incidence of spontaneous tumors. The findings implicate PAPP-A as a critical regulator of lifespan and age-related diseases, and suggest PAPP-A as a possible target to promote longevity.
Conover
Cheryl A
CA
Endocrine Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. conover.cheryl@mayo.edu
Bale
Laurie K
LK
D000818:Animals; D005260:Female; D008136:Longevity / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*
D011266:Pregnancy-Associated Plasma Protein-A