Leydig cell tumor and hyperplasia: a review.
We describe the role of Leydig cells in normal, hyperplastic and neoplastic testis. Recent acquisitions on etiology and pathobiology of Leydig cell proliferations, unusual microscopic presentations and clinical and morphologic features predictive of malignancy are reported.
Department of Pathology, National Cancer Institute Foundation, Milan, Italy. maurizio.colecchia@istitutotumori.milano.it
Maurizio
M
Colecchia
Manuel
M
Nistal
Pilar
P
Gonzalez-Peramato
Luca
L
Carmignani
Roberto
R
Salvioni
Nicola
N
Nicolai
Javier
J
Regadera
D002454:Cell Differentiation; D006801:Humans; D006965:Hyperplasia; D007984:Leydig Cell Tumor / Q000473:pathology* / Q000648:ultrastructure; D007985:Leydig Cells / Q000473:pathology; D008297:Male; D013736:Testicular Neoplasms / Q000473:pathology*; D013737:Testis / Q000166:cytology / Q000196:embryology