Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome.
Leptin, particularly in its free form, is deeply involved in the regulation of energy balance. Insulin was suggested to influence plasmatic leptin levels and soluble leptin receptor in humans. However, this study indicates that metformin treatment, although improving insulin levels, does not exert a significant effect on either total leptin level or free leptin index in obese women with hyperinsulinemia and PCOS.
Romualdi
Daniela
D
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
Campagna
Giuseppe
G
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
Selvaggi
Luigi
L
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
Cento
Rosa
R
"Oasi" Institute for Research, Troina, Italy.
Proto
Caterina
C
"Oasi" Institute for Research, Troina, Italy.
Lanzone
Antonio
A
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy; "Oasi" Institute for Research, Troina, Italy.
Guido
Maurizio
M
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: maurizioguido@libero.it.
D000328:Adult; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008687:Metformin / Q000494:pharmacology*; D009765:Obesity / Q000097:blood* / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications
D007004:Hypoglycemic Agents; D007328:Insulin; D020738:Leptin; D008687:Metformin