Self-assembly of a cyclobutane beta-tetrapeptide to form nanosized structures.
A beta-tetrapeptide made up of homochiral cyclobutane residues displays conformational bias in solution prompted by the formation of intramolecular hydrogen bonds. Moreover, this compound self-assembles to produce nanosized fibrils and, in some media, it also forms a gel. The combination of NMR, TEM, AFM, and theoretical calculations has proven to be very useful in obtaining insight into the details of these new structures.
Rúa
Federico
F
Departament de Química, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Boussert
Stéphanie
S
Parella
Teodor
T
Díez-Pérez
Ismael
I
Branchadell
Vicenç
V
Giralt
Ernest
E
Ortuño
Rosa M
RM
D003503:Cyclobutanes / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry
D003503:Cyclobutanes; D009842:Oligopeptides; D012996:Solutions