Correlation between circulating adhesion molecule levels and albuminuria in type 2 diabetic normotensive patients.
BACKGROUND
Endothelial dysfunction is a common feature in type 2 diabetic patients and is associated with inflammation, increased levels of circulating soluble adhesion molecules, and urinary albumin excretion. The aim of this study was to evaluate the role of circulating soluble adhesion molecules in the development of albuminuria.


METHODS
Thirty normotensive type-2 diabetic patients and 30 non-diabetic normotensive subjects were studied. VCAM-1, ICAM-1, and E-selectin were measured by ELISA and 24-h urinary albumin excretion was also measured (nephelometry). Relationships between the levels of circulating adhesion molecules and albuminuria were examined with Spearman's correlation coefficient. Statistical analysis was performed with ANOVA.


RESULTS
It was found that diabetic patients have significantly (p<0.001) higher levels of circulating soluble adhesion molecules than control subjects. When levels of circulating soluble adhesion molecules were correlated with albuminuria, a significant correlation was found between VCAM-1 levels and 24-h urinary albumin excretion.


CONCLUSIONS
These results suggest that VCAM-1 may be a marker of nephropathy in normotensive type 2 diabetic patients.
Rubio-Guerra
Alberto Francisco
AF
Hypertension Clinic, Hospital General de Ticomán SS DF, México DF. clinhta@hotmail.com
Vargas-Robles
Hilda
H
Ayala
German Vargas
GV
Escalante-Acosta
Bruno Alfonso
BA
D000419:Albuminuria / Q000097:blood* / Q000150:complications*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D003928:Diabetic Nephropathies / Q000473:pathology; D019040:E-Selectin / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry / Q000379:methods; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1