[Synthesis, structure, and biological properties of some 8alpha-analogues of steroid estrogens with fluorine in position 2].
A total synthesis of 8alpha analogues of steroid estrogens with fluorine in position 2 was achieved. Structural features of these compounds were studied by the example of 17beta-acetoxy-2-fluoro-3-methoxy-8alpha-estra-1,3,5(10)-triene. It was shown that the 8alpha analogues of 2-fluorosubstituted steroid estrogens have a low uterotropic activity and retain the osteoprotective and hypocholesterolemic activities.
Belov
V N
VN
Dudkin
V Iu
VIu
Urusova
E A
EA
Starova
G L
GL
Selivanov
S I
SI
Nikolaev
S V
SV
Eshchenko
N D
ND
Morozkina
S N
SN
Shavva
A G
AG
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D004963:Estrenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004967:Estrogens / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D005461:Fluorine; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects
C523838:17beta-acetoxy-2-fluoro-3-methoxy-8alpha-estra-1,3,5(10)-triene; D000924:Anticholesteremic Agents; D050071:Bone Density Conservation Agents; D004963:Estrenes; D004967:Estrogens; D005461:Fluorine; D002784:Cholesterol