[Serum lipids as biochemical manifestations of hepatic alcoholic, viral, and mixed viral-and-alcoholic lesion].
The parameters of lipids, which reflect the morphological manifestations of hepatic damages of alcoholic, viral, and mixed viral-and-alcoholic genesis, were determined. The serum lipid spectrum was studied in 50 alcoholic patients without viral hepatitis markers, in 30 patients with chronic viral hepatitis B (CVHB), and in 40 with CVHB concurrent with alcoholism. Puncture biopsy of the liver and a histological study of its biopsy specimen were made in 47 patients. Total lipid levels above 9.0 g/l were the most typical biochemical marker of alcoholic damage to the liver; lysophosphatidylcholine (LPC) levels below 7% were a marker of its viral damage; total lipid levels above 9.5 g/l and LPC levels below 5% were a marker of its viral-and-alcoholic damage. Thus, serum lipids may be used as biochemical markers of the morphological manifestations of hepatic damages of various genesis.
Makarov
V K
VK
Khomeriki
S G
SG
D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000150:complications / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D001707:Biopsy, Needle; D019694:Hepatitis B, Chronic / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism / Q000473:pathology / Q000821:virology; D008108:Liver Diseases, Alcoholic / Q000097:blood* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D008055:Lipids