Hyperemesis gravidarum in Eastern Asian population.
OBJECTIVE
To investigate the clinical features of hyperemesis gravidarum in Eastern Asian women.


METHODS
Retrospective cohort study was conducted based on delivery records. Hyperemesis gravidarum was defined as a pregnancy with severe nausea and vomiting necessitating hospitalization with a body weight loss of over 5% from pre-pregnancy weight with ketonuria. The onset is at 10 weeks of gestation or less. Maternal and neonatal variables were compared.


RESULTS
There were 3,350 singleton deliveries in the study period. All subjects were Eastern Asian women. Hyperemesis gravidarum was observed in 119 cases (3.6%). Hyperemesis gravidarum subjects had a smaller pre-pregnancy body weight (50.5 +/- 0.64 kg vs. 51.8 +/- 0.16 kg, p = 0.046) and a smaller pre-pregnancy body mass index compared to non-hyperemetic subjects (20.2 +/- 0.21 kg/m2 vs. 20.8 +/- 0.06 kg/m2, p = 0.02).


CONCLUSIONS
The Eastern Asian population had a significantly higher incidence of hyperemesis gravidarum. Small pre-pregnancy body habitus increased the risk of hyperemesis gravidarum.
Matsuo
Koji
K
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan. koji.matsuo@gmail.com
Ushioda
Norichika
N
Nagamatsu
Masaaki
M
Kimura
Tadashi
T
D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D006760:Hospitalization; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000175:diagnosis* / Q000453:epidemiology* / Q000208:ethnology / Q000209:etiology / Q000473:pathology; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008499:Medical Records; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index