Synthesis and properties of O-carboxymethyl chitosan/methoxy poly(ethylene glycol) graft copolymers.
O-carboxymethyl chitosan/methoxy poly(ethylene glycol) graft copolymers (OCMCS-g-MPEGs) with different degrees of substitution (DS) were synthesized by reductive N-alkylation of chitosan with poly(ethylene glycol) aldehyde. The properties of OCMCS-g-MPEGs, including the solubility, structure, hydrodynamic behaviors, isoelectric point (IEP) and interaction with water-soluble chitosan, were investigated. As a PEGylated polyampholyte, OCMCS-g-MPEGs can resolve in water over all pH range and the pH value at IEP (pH(IEP)) decreases when DS increases. The hydrodynamic behaviors of OCMCS-g-MPEGs in deionized H(2)O are markedly affected by DS and pH(IEP) in the experiment concentration range. The particle size of the complexes of OCMCS-g-MPEGs with water-soluble chitosan is strongly affected by the concentration of water-soluble chitosan and the pH value.
Dong
An-Jie
AJ
Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China. ajdong@tju.edu.cn
Feng
Meng-Huang
MH
Qi
Hai-Ying
HY
Li
Shan-Shan
SS
Deng
Lian-Dong
LD
D001672:Biocompatible Materials / Q000138:chemical synthesis; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis*
D001672:Biocompatible Materials; C504164:O-carboxymethylchitosan; D011108:Polymers; D011092:Polyethylene Glycols; D048271:Chitosan