[Evaluation of immunobiological activity of Francisella tularensis C-complex preparations as promising component of subunit vaccines].
Data on influence of Francisella tularensis C-complex preparations on formation of immunity against tularemia are presented. Study of cellular immunity characteristics as well as dynamics of antibody response was carried out on white mice and guinea pigs models. Absence of toxicity, pyrogenicity, and negative effects on immunocompetent cells in combination with protective activity points to possibility of use the C-complex as a component of a subunit vaccine.
Volokh
O A
OA
Shepelev
I A
IA
Firsova
V V
VV
Khramkova
E M
EM
Avdeeva
N G
NG
Samokhvalova
Iu I
IuI
Eremin
S A
SA
Diatlov
I A
IA
Zhemchugov
V E
VE
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D017209:Apoptosis; D001426:Bacterial Proteins / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000633:toxicity; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D005604:Francisella tularensis / Q000276:immunology*; D006168:Guinea Pigs; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D013154:Spleen / Q000502:physiology; D013950:Thymus Gland / Q000502:physiology; D014406:Tularemia / Q000097:blood / Q000276:immunology* / Q000517:prevention & control*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology / Q000633:toxicity
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D008565:Membrane Proteins; D014614:Vaccines, Synthetic