Toward nanoscale genome sequencing.
This article reports on the state-of-the-art technologies that sequence DNA using miniaturized devices. The article considers the miniaturization of existing technologies for sequencing DNA and the opportunities for cost reduction that 'on-chip' devices can deliver. The ability to construct nano-scale structures and perform measurements using novel nano-scale effects has provided new opportunities to identify nucleotides directly using physical, and not chemical, methods. The challenges that these technologies need to overcome to provide a US$1000-genome sequencing technology are also presented.
Ryan
Declan
D
Department of Electrical Engineering, University of Washington Paul Allen Center, AE100R Box 352500 Seattle, WA 98195, USA.
Rahimi
Maryam
M
Lund
John
J
Mehta
Ranjana
R
Parviz
Babak A
BA
D006801:Humans; D056656:Lab-On-A-Chip Devices; D046208:Microchip Analytical Procedures / Q000379:methods*; D036103:Nanotechnology / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*