Retroperitoneal and visceral sarcomas: issues for the general surgeon.
Sarcomas represent a rare, heterogeneous group of malignant tumors that arise from the mesenchymal tissues of the body. Although infrequently encountered, these tumors generate vigorous academic interest and an ever-expanding volume of medical literature. Chemotherapy is widely regarded as ineffective because of the often-large tumor burden and lack of good therapeutic drugs. Radiation therapy is often difficult to administer because of locoregional toxicity. Fortunately, targeted immunologic therapies have shown promise in some specific gastrointestinal mesenchymal tumors. To date, sarcoma remains a malignancy best treated operatively. Given the wide heterogeneity and biology of these tumors and the amount of new data available, a review of the current literature is warranted. The first installment of this review series dealt with extremity and trunk soft tissue sarcomas; this one will focus on retroperitoneal and visceral sarcomas and the management challenges they pose.
Woodall
Charles E
CE
Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, Kentucky 40202, USA.
Scoggins
Charles R
CR
D000008:Abdominal Neoplasms / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D046152:Gastrointestinal Stromal Tumors / Q000601:surgery; D006801:Humans; D018714:Radiotherapy, Adjuvant; D012186:Retroperitoneal Neoplasms / Q000601:surgery*; D012509:Sarcoma / Q000556:secondary / Q000601:surgery*