Effect of pore former on the properties of casted film prepared from blends of Eudragit NE 30 D and Eudragit L 30 D-55.
The casted films of aqueous dispersions of Eudragit NE30 D and Eudragit L30 D-55 containing pore former were prepared. The study investigated the influence of pore former on basic model drug clarithromycin release, water uptake and water vapor permeability from casted film prepared from the blends of neutral polymer dispersion of Eudragit NE30 D and enteric polymer dispersion of Eudragit L30 D-55. This study was concluded that pore former hydroxypropyl methyl cellulose, lactose, polyethylene glycol (PEG) and polyvinyl pyrrolidon (PVP) was released at the beginning of the release process, the rate and extent of water uptake of the polymeric films were much higher in phosphate buffer pH 6.8 than in pH 5.0 and the concentration of pore former have a significant influence on the permeability to water vapour.
Zhang
Xiangrong
X
Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, P.R. China. zhangxr@vip.sina.com
Wang
Yanjiao
Y
Wang
Jing
J
Wang
Yan
Y
Li
Sanming
S
D000465:Algorithms; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D017291:Clarithromycin / Q000737:chemistry; D004058:Diffusion; D005079:Excipients; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D007785:Lactose / Q000737:chemistry; D008567:Membranes, Artificial; D008747:Methylcellulose / Q000031:analogs & derivatives; D010539:Permeability; D011092:Polyethylene Glycols / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D005079:Excipients; D008567:Membranes, Artificial; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D065347:Hypromellose Derivatives; D011092:Polyethylene Glycols; D008747:Methylcellulose; D011205:Povidone; D017291:Clarithromycin; D007785:Lactose