[Moraprenylphosphates suppress reproduction of Taylor murine encephalomyelitis virus and accumulation of VP3 viral protein in susceptible cell cultures BHK-21 and P388D1].
Influence of moraprenylphosphates (phosphorylated polyprenol of plant origin) upon the accumulation of Taylor murine encephalomyelitis virus VP3 protein in the susceptible cell cultures was studied. It has been shown that moraprenylphosphates inhibited the accumulation of VP3 at early stages of infectious process. Moraprenylphosphates were found to decrease infectivity of the virus as well as virus-induced cellular apoptosis. Mechanisms of immunomodulating and antiviral activity of moraprenylphosphates and prospects of their use as antiviral drugs have been discussed.
T N
TN
Kozhevnikova
E G
EG
Viktorova
V G
VG
Kozlov
A N
AN
Narovlianskiĭ
A V
AV
Sanin
A V
AV
Pronin
S V
SV
Ozherelkov
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D036022:Capsid Proteins / Q000096:biosynthesis / Q000187:drug effects; D018188:Cardiovirus Infections / Q000821:virology; D002460:Cell Line / Q000187:drug effects / Q000821:virology; D006224:Cricetinae; D051379:Mice; D011106:Polyisoprenyl Phosphates / Q000494:pharmacology*; D017945:Theilovirus / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D014774:Virulence / Q000187:drug effects
D000998:Antiviral Agents; D036022:Capsid Proteins; D011106:Polyisoprenyl Phosphates; C442559:VP3 protein, Theilovirus