[Hypoparathyroidism associated with autoimmune disorder].
Isolated and acquired hypoparathyroidism occurs as an autoimmune disorder either alone or in association with other autoimmune diseases. Reduced PTH (parathyroid hormone) secretion due to disorder of Ca-sensing regulation in parathyroid gland is most commonly caused by activating mutations of the CaSR (Ca-sensing receptor) gene. There has been accumulating evidence that it also occurs as a result of activating autoantibodies directed to CaSR. Hypoparathyroidism is one of the most common endocrine manifestation in APECED (Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy) , which is also known as APS (Autoimmune Polyendocrinopathy Syndrome) type I . In APECED, the spectrum of epitope responsible for the hypoparathyroidism is presumably CaSR. It remains unclear how autoimmunity against CaSR occurs and how much patients caused by this disorder exist.
Yamauchi
Mika
M
Shimane University Faculty of Medicine, Internal Medicine 1, Japan.
Sugimoto
Toshitsugu
T
D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000150:complications*; D002762:Cholecalciferol / Q000627:therapeutic use; D006801:Humans; D007011:Hypoparathyroidism / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016884:Polyendocrinopathies, Autoimmune / Q000175:diagnosis / Q000209:etiology; D044169:Receptors, Calcium-Sensing / Q000276:immunology*
D001323:Autoantibodies; D044169:Receptors, Calcium-Sensing; D002762:Cholecalciferol