Outcomes of transplantation in children with primary hepatic malignancy.
HBL and HCC are the most common hepatic malignancies in children. The role of OLT in children with HCC is still a matter of debate. The aim of this study was to review our experience of OLT for HCC. Medical records of patients (<18 yr) who underwent OLT for HCC were reviewed and compared to children who underwent OLT for HBL and for indications other than malignancy. There were 25 patients: HCC (10 cases) and HBL (15 cases). The actuarial patient survival for HCC at one and five yr was 100% and 83.3%, for the HBL group the survival was 86.7% at both one and five yr, and for indications (n=377) other than malignancy the patient survival for pediatric OLT at our center was 87.7% and 84.7% at one and five yr, respectively. The actuarial recurrence free survival at five yr was 83.3% for HCC and 66.8% for HBL. In conclusion, OLT is a good therapeutic modality for children with HCC and HBL.
Divisions of Transplantation, Lucile Salter Packard Children's Hospital and Stanford University School of Medicine, Stanford, CA 94304, USA.
Mona
M
Beaunoyer
Jason M
JM
Vanatta
Makoto
M
Ogihara
Debra
D
Strichartz
Gary
G
Dahl
William E
WE
Berquist
Ricardo O
RO
Castillo
Kenneth L
KL
Cox
Carlos O
CO
Esquivel
D000293:Adolescent; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018197:Hepatoblastoma / Q000601:surgery*; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome