[Urethroplasty with tissue matrix. Microsurgical animal experiments with small intestinal submucosa].
BACKGROUND
The purpose of this study was to examine whether use of small intestinal submucosa in microsurgical urethroplasty in Wistar rats represents an alternative.


METHODS
In 20 Wistar rats microsurgical urethroplasty with small intestinal submucosa was done to repair distal or proximal urethral defects. Four weeks later urethral calibration and urethrography were performed in addition to histological studies.


CONCLUSIONS
Of the 20 animals, 19 survived the observation period without evidence of fistulas, strictures, stenoses, or necroses. The histological results confirmed an intact tissue layer.
Urologische Klinik, Südharz-Krankenhaus gGmbH, Kochstrasse 39, 99734 Nordhausen. matthiasbeintker@web.de
M
M
Beintker
B
B
Vogt
J
J
Schubert
H
H
Schubert
H
H
Kosmehl
D000818:Animals; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000637:transplantation*; D006801:Humans; D007021:Hypospadias / Q000473:pathology / Q000601:surgery*; D007413:Intestinal Mucosa / Q000637:transplantation*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D051381:Rats; D014521:Urethra / Q000000981:diagnostic imaging / Q000601:surgery*; D014567:Urography; D014945:Wound Healing / Q000502:physiology