[Prognostic significance of DNA ploidy in disseminated malignant skin melanoma and the effectiveness of interleukin-2 (IL-2) treatment].
Retrospective study of DNA ploidy was performed on cytologic slides derived from 30 patients with malignant melanoma (stage IV) before interleukin-2 (IL-2) treatment. Twelve patients were tested after two courses of treatment. Diploid tumors were detected in 4, aneuploid - 26. Significant differences in survival versus DNA ploidy (p=0.025) and response to treatment (p=0.016) were found by use of single-factor analysis (Caplan-Meyer). However, multivariate proportional-hazard regression method (Cox) identified high prognostic relevance (p=0.00007) of a combination of 5 factors: DNA ploidy (p=0.008), gender (p=0.015), blood group (p=0.015), sum total of metastasis diameter (p=0.035) and response to treatment (p=0.042). Significant drop in DNA level after treatment was reported in 9 out of 12 patients; no change - 1 and a rise in 2. The post treatment increase involved rapid progression of tumor.
Novik
A V
AV
Novik
B I
BI
Moiseenko
V M
VM
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004273:DNA, Neoplasm; D018450:Disease Progression; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000235:genetics* / Q000401:mortality; D008875:Middle Aged; D015999:Multivariate Analysis; D011003:Ploidies; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000401:mortality
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D007376:Interleukin-2