Stem cells as screening tools in drug discovery.
All physiologic processes operate in a cellular setting. Therefore, drug discoverers need the highest quality cells as they pursue the next generation of safe and effective medicines. Recently, investigators have begun to consider stem cells as a new source of predictive, cell-based assays in drug discovery. Stem cell technology still has hurdles to overcome before these cells are fully accepted as decision-making reagents and amenable to high-throughput screening. However, with global research interest in stem cell biology, significant advances in the application of these cells in drug discovery have been reported. These advances are aligned with three important stages of pharmaceutical research: target discovery and validation, identification of efficacious chemical leads, and drug safety pharmacology. This concise review describes the application of stem cells in these areas of drug discovery with emphasis on molecular screening opportunities.
Center of Excellence for Genetically Modified Models, Pfizer Global Research and Development, Groton, CT 06340, United States. john.d.mcneish@pfizer.com
John D
JD
McNeish
D000818:Animals; D002454:Cell Differentiation; D015195:Drug Design; D006801:Humans; D013234:Stem Cells / Q000166:cytology