Triterpenoid saponins and anti-inflammatory activity of Codonopsis lanceolata.
The ethanolic root extract of Codonopsis lanceolata were evaluated for anti-inflammatory activity using the carrageenan induced rat hind paw edema model and displayed a significant activity of 51.82% inhibition at 200 mg/kg at 3 h (p < 0.05). Further isolation of the extract yielded two new triterpenoid saponins, named codonolaside I (1) and codonolaside II (2). The spectroscopic and chemical data revealed their structures to be 3-O-[beta-D-xylopyranosyl (1->3)-(6'-O-methyl)-beta-D-glucuronopyranosyl]-30, 16a-dihydroxyolean-12-ene-28-oic acid 28-O-[P-D-xylopyranosyl (1-->4)-alpha-L-rhamnpyranosyl (1-->2)-alpha-L-arabinopyranosyl] ester (1), and 3beta, 16alpha-dihydroxyolean-12-ene-28-oic acid 28-O-[beta-D-xylopyranosyl (1-->3)-beta-D-xylopyranosyl (1-->4)-alpha-L-rhamnpyranosyl (1-->2)-alpha-L-arabinopyranosyl] ester (2).
School of Pharmacy, Changchun College of Traditional Chinese Medicine, Changchun, People's Republic of China.
Jian-Ping
JP
Li
Zhi-Min
ZM
Liang
Zhong
Z
Yuan
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002240:Carbohydrate Sequence; D002351:Carrageenan; D029745:Codonopsis / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008969:Molecular Sequence Data; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C522364:codonolaside I; D002351:Carrageenan; D001241:Aspirin