Bowel-associated dermatosis-arthritis syndrome in a patient with appendicitis.
BACKGROUND
Bowel-associated dermatosis-arthritis syndrome (BADAS) is defined by the presence of pustular vasculitic skin lesions usually associated with blind loops of the bowel, either after Billroth II or ileojejunal bypass surgery or caused by a chronic inflammatory bowel disease such as Crohn's disease or ulcerative colitis.


METHODS
A 50-year-old patient is presented with an unusual case of pustulo hemorrhagic vasculitis over the lower arms and legs that appeared ten days before the first symptoms of appendicitis, partially regressed, and reappeared five days after appendectomy. Laboratory tests showed anemia, an elevated erythrocyte sedimentation rate, and C-reactive protein as well as a polyclonal increase in IgG and IgA levels, erythrocyturia and proteinuria. Histopathological examination of a skin biopsy indicated the suspected diagnosis. During hospitalization the patient developed arthropathy with swelling of the metacarpophalangeal and interphalangeal joints and ankles. The patient was treated with systemic antibiotics and corticosteroids, which caused resolution of the symptoms.


CONCLUSIONS
This report speculates that appendicitis was the possible cause of BADAS in this case.
Prpić-Massari
Larisa
L
Department of Dermatovenerology, Medical Faculty, University of Rijeka, Rijeka, Croatia. larisaprpic@yahoo.com
Kastelan
Marija
M
Brajac
Ines
I
Cabrijan
Leo
L
Zamolo
Gordana
G
Massari
Drazen
D
D001064:Appendicitis / Q000150:complications*; D001168:Arthritis / Q000150:complications* / Q000175:diagnosis; D001706:Biopsy; D006801:Humans; D007249:Inflammation; D007421:Intestine, Small / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000175:diagnosis; D013577:Syndrome