Fourth-generation fluoroquinolone-resistant bacterial keratitis.
Corneal scrapings were collected from a case of keratitis and microbiological investigations done. Coagulase-negative Staphylococcus (Staphylococcus epidermidis) was identified on culture, and antibiotic susceptibility tests were performed. Treatment was started with topical cefazolin sulfate 5% and gatifloxacin 0.3%; this was subsequently changed to vancomycin 5% and tobramycin sulfate 1.3% based on the sensitivity pattern. The isolates of this bacterium were susceptible to vancomycin, tobramycin, and gentamicin, and resistance was present against moxifloxacin, gatifloxacin, ciprofloxacin, and cefazolin. The case highlights the occurrence of keratitis caused by coagulase-negative Staphylococcus that is resistant to treatment with moxifloxacin.
Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Vishal
V
Jhanji
Namrata
N
Sharma
Gita
G
Satpathy
Jeewan
J
Titiyal
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001372:Aza Compounds / Q000494:pharmacology*; D003320:Corneal Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D011804:Quinolines / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000302:isolation & purification*; D014031:Tobramycin / Q000627:therapeutic use; D014640:Vancomycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D014640:Vancomycin; D000077266:Moxifloxacin; D014031:Tobramycin