Oxidative stress: A dead end or a laboratory hypothesis?
Oxidative stress is a highly used definition. The relevance of this concept is discussed in the light of the questionable effects of antioxidants in vitro and in vivo. The description of local cellular sources of oxidants and radicals as pathophysiologically important in signaling suggests the need for a re-discussion of the holistic concept of oxidative stress.
Azzi
Angelo
A
Vascular Biology Laboratory, JM USDA-HNRCA at Tufts University, Boston, USA. angelo.azzi@tuffs.edu
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004249:DNA Damage; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D000975:Antioxidants; D005609:Free Radicals; D016877:Oxidants