The use of EEG in the diagnosis of dementia with Lewy bodies.
Although reports on EEG in dementia with Lewy bodies (DLB) are conflicting, the recent diagnostic guidelines define EEG abnormalities as being supportive for the diagnosis. We examined EEG abnormalities in 18 patients with DLB, 34 patients with Alzheimer's disease (AD) and 36 patients with subjective memory complaints (SMC) using the Grand Total EEG (GTE) score. There was a difference in median GTE score of DLB (11.0), AD (4.8) and SMC (2.5) (p<0.001). Patients with DLB had higher scores than patients with AD. ROC analyses revealed that patients with DLB could be distinguished from those with AD with a sensitivity of 72% and a specificity of 85% at a GTE cut-off of 9.5. The association between GTE and DLB was independent of age, gender, Mini Mental State Examination and medication use. Frontal intermittent rhythmic delta activity (FIRDA) was found in 2.9% of the patients with AD and in 33.3% of the patients with DLB. The GTE is a simple EEG scoring method that can be helpful in the differential diagnosis between DLB and AD with good sensitivity and specificity.
Alzheimer Center, VU University Medical Center, Department of Neurology, Amsterdam, The Netherlands. g.roks@elisabeth.nl
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Roks
E S C
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Korf
W M
WM
van der Flier
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Scheltens
C J
CJ
Stam
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000503:physiopathology; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000503:physiopathology; D008609:Mental Status Schedule; D008875:Middle Aged; D010348:Patient Care Team; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted