Myocardial myocyte remodeling and fibrosis in the cardiometabolic syndrome.
Myocardial cellular and extracellular matrix remodeling are important in the development of left ventricular hypertrophy and are essential for the adaptive and maladaptive changes associated with the cardiometabolic syndrome. This brief review of myocyte remodeling also presents preliminary observational findings regarding myocardial adaptive hypertrophy remodeling, including an increase in mitochondria and capillaries, convolutions and lengthening of intercalated discs, the addition of sarcomeres, thickened Z lines, and the novel presence of pericapillary fibrosis (in addition to perivascular arteriolar fibrosis). The 11-week-old TG(mREN-2)27 transgene rat model of tissue angiotensin II overexpression, which develops hypertension and insulin resistance, was chosen to examine both myocyte hypertrophy and extracellular matrix fibrosis. This review and the preliminary observational findings may provide the clinician and researcher a better understanding of remodeling changes in the myocardium and ultimately foster earlier recognition and therapeutic interventions.
Department of Internal Medicine University of Missouri School of Medicine, Columbia, MO 65212, USA. mrh29@usmo.com
Melvin R
MR
Hayden
Nazif
N
Chowdhury
Guru
G
Govindarajan
Poorna R
PR
Karuparthi
Javad
J
Habibi
James R
JR
Sowers
D000419:Albuminuria / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D030801:Animals, Genetically Modified; D009202:Cardiomyopathies / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000378:metabolism; D005355:Fibrosis; D018149:Glucose Intolerance / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006946:Hyperinsulinism / Q000473:pathology / Q000503:physiopathology; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology; D006984:Hypertrophy; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology*; D009765:Obesity / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress; D051381:Rats; D012083:Renin / Q000235:genetics / Q000378:metabolism; D020257:Ventricular Remodeling
C473112:Ren2 protein, mouse; D012083:Renin