Strongyloides stercoralis septicaemia following steroid therapy for eosinophilia: report of three cases.
Three apparently immunocompetent patients died in the intensive care unit at Loni Hospital, Ahmednagar, Maharashtra, India, between 2001 and 2006 due to multiorgan failure and Strongyloides stercoralis septicaemia following a short course of corticosteroid (prednisolone) therapy of 6-17 days for peripheral blood eosinophilia associated with urticaria and angioneurotic oedema, bronchospasm, and generalised aches and pains, respectively. None of the patients had any obvious lymphoproliferative disorder, solid tumour or HIV 1+2 infection as an underlying immunosuppressive condition. These three patients highlight the extreme caution that must be exercised in administering a moderate dose of oral corticosteroid even for a short period of time as well as the high degree of suspicion that needs to be maintained if there is clinical deterioration following corticosteroid therapy.
Ghosh
Kinjalka
K
Pravara Institute of Medical Sciences, Pravaranagar, Loni, Ahmednagar, Maharashtra, India.
Ghosh
Kanjaksha
K
D000328:Adult; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004802:Eosinophilia / Q000188:drug therapy*; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology* / Q000469:parasitology; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D018805:Sepsis / Q000139:chemically induced*; D017171:Strongyloides stercoralis; D013322:Strongyloidiasis / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D011239:Prednisolone