Clinical, laboratory and neuroimage findings in juvenile systemic lupus erythematosus presenting involvement of the nervous system.
To characterize neurological involvement in juvenile systemic lupus erythe-matosus.



The charts of all patients with the diagnosis of systemic lupus erythematosus before the age of 16 years, followed at the Rheumatology Unit of Pequeno Príncipe Hospital, from January 1992 to January 2006, were retrospectively reviewed, highlighting neuropsychiatric aspects.



Forty-seven patients were included. Neuropsychiatric syndromes were found 29 (61.7%): seizures (17 / 36.2%), intractable headache (7 / 14.9%), mood disorders (5 / 10.6%), cerebrovascular disease (4 / 8.5%), acute confusional state (3 / 6.4%), aseptic meningitis (3 / 6.4%), psychosis (3 / 6.4%), chorea (3 / 6.4%), Guillain-Barré syndrome (2 / 4.3%) and cranial neuropathy (1 / 2.1%). Morbidity indexes (SLEDAI and SLICC) were higher among patients with neuropsychiatric manifestations (p<0.05).



Neuropsychiatric syndromes are frequent, and add significant morbidity to juvenile systemic lupus erythematosus.
Spinosa
Mônica Jaques
MJ
Unidade de Neurologia Infantil Pequeno Príncipe e Unidade de Reumatologia Infantil do Hospital Pequeno Príncipe, Hospital Pequeno Príncipe, Curitiba PR, Brazil. monicaspinosa@yahoo.com
Bandeira
Márcia
M
Liberalesso
Paulo Breno Noronha
PB
Vieira
Simone Carreiro
SC
Janz
Loris Lady
LL
Sá
Eliane Gomes de
EG
Löhr
Alfredo
A
D000293:Adolescent; D017153:Antibodies, Anticardiolipin / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D020945:Lupus Vasculitis, Central Nervous System / Q000150:complications / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
D017153:Antibodies, Anticardiolipin