Clinical features of probable medication-overuse headache: a retrospective study in Japan.
This study examined the clinical picture of probable medication-overuse headache (MOH) and the presence of any features peculiar to Japan. In a retrospective study of 47 patients, type of primary headache, type of medicine overused, method and result of withdrawal were investigated. Among the 47 patients, 80.9% had migraine only, and 85.1% overused combination medications. While 36 patients (76.6%) succeeded in withdrawal, five patients (10.6%) failed. One patient (2.1%) had not improved by 2 months after withdrawal and was diagnosed with chronic migraine and chronic tension-type headache without MOH. The remaining five patients (10.6%) dropped out. All dropout patients were recommended abrupt inpatient withdrawal, but chose abrupt outpatient withdrawal. As features peculiar to Japan, many patients with probable MOH overused combination analgesics, particularly females.
Department of Neurology, Shizuoka Red Cross Hospital, Shizuoka, Japan. nboimai@ac.mbn.or.jp
N
N
Imai
E
E
Kitamura
T
T
Konishi
Y
Y
Suzuki
M
M
Serizawa
T
T
Okabe
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000009:adverse effects*; D005260:Female; D006261:Headache / Q000139:chemically induced* / Q000453:epidemiology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008508:Medication Errors / Q000009:adverse effects* / Q000706:statistics & numerical data*; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
D000700:Analgesics