The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation.
Polycomb proteins are required for maintenance of silent chromatin states via histone H3 Lys27 trimethylation (H3K27me3) in animals, but homologs are not found in plant genomes. Using a DamID-chip method, we found that the Arabidopsis thaliana chromodomain-containing protein LHP1 colocalizes with H3K27me3 genome-wide. The LHP1 chromodomain also binds H3K27me3 with high affinity, suggesting that LHP1 has functions similar to those of Polycomb.
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA.
Xiaoyu
X
Zhang
Sophie
S
Germann
Bartlomiej J
BJ
Blus
Sepideh
S
Khorasanizadeh
Valerie
V
Gaudin
Steven E
SE
Jacobsen
D017360:Arabidopsis / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism*; D008745:Methylation
D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; C443901:like heterochromatin protein 1; D008239:Lysine