Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels.
The insulin (INS) and IGF 2 (IGF2) genes are in close proximity to each other and undergo maternal imprinting during fetal growth. We investigated the association between maternal and umbilical cord IGF 2 protein (IGF-II) levels and single nucleotide polymorphisms (SNPs) in the INS and IGF2 genes in 207 healthy African-American mother-newborn pairs. No association was found between maternal IGF-II levels and polymorphism in the INS-IGF2 locus. A significant association was found between newborn IGF-II levels and two SNPs (rs3842738 and rs689) at the 5' end of the INS-IGF2 locus. Analyses of haplotypes inferred from these two SNPs demonstrate a significant relationship between paternally transmitted haplotypes and newborn IGF-II levels, but no association with maternally transmitted haplotypes.
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA. radkins1@utmem.edu
Ronald M
RM
Adkins
John N
JN
Fain
Julia
J
Krushkal
Chad K
CK
Klauser
Everett F
EF
Magann
John C
JC
Morrison
D000328:Adult; D001741:Black or African American / Q000235:genetics*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D047109:Fetal Development / Q000235:genetics; D005787:Gene Frequency; D018392:Genomic Imprinting; D005865:Gestational Age; D006239:Haplotypes; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000235:genetics*; D007335:Insulin-Like Growth Factor II; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000032:analysis / Q000235:genetics*; D014481:United States
C035170:IGF2 protein, human; D007328:Insulin; D011506:Proteins; D007335:Insulin-Like Growth Factor II