Indium(III)-catalyzed addition of diethyl acetamidomalonate to terminal alkynes: an efficient approach to beta-branched alpha-amino acids.
The indium(III)-catalyzed Markovnikov addition of active methylene compounds to terminal alkynes has been expanded further to include diethyl acetamidomalonate. This reaction has been studied, and a practical approach to beta-branched alpha-amino acids was developed.
Angell
Paul
P
Research API, Pfizer Global Research & Development, Ann Arbor Laboratories, Pfizer, Inc., 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA.
Blazecka
Peter G
PG
Lovdahl
Mark
M
Zhang
Ji
J
D000480:Alkynes / Q000737:chemistry*; D000597:Amino Acids, Branched-Chain; D002384:Catalysis; D007204:Indium / Q000737:chemistry*
D000480:Alkynes; D000597:Amino Acids, Branched-Chain; D007204:Indium