The genetics of frontotemporal dementia.
This article describes the remarkable progress that has been made over the past decade in identifying the genetic contribution to frontotemporal dementia. The clinical and neuropathologic features of frontotemporal dementia with parkinsonism linked to chromosome 17 and the nature of the mutations in the progranulin and microtubule-associated protein tau genes are emphasized.
Haugarvoll
Kristoffer
K
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
Wszolek
Zbigniew K
ZK
Hutton
Michael
M
D000251:Adenosine Triphosphatases / Q000235:genetics; D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics; D003704:Dementia / Q000235:genetics* / Q000473:pathology; D056827:Endosomal Sorting Complexes Required for Transport; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D000077153:Progranulins; D013702:Temporal Lobe / Q000473:pathology; D000074405:Valosin Containing Protein; D016875:tau Proteins / Q000235:genetics
C503812:CHMP2B protein, human; D018797:Cell Cycle Proteins; D056827:Endosomal Sorting Complexes Required for Transport; C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; C054369:MAPT protein, human; D009419:Nerve Tissue Proteins; D000077153:Progranulins; D016875:tau Proteins; D000251:Adenosine Triphosphatases; D000074405:Valosin Containing Protein