[The influence of coordinational germanium compounds on the activity of glycosidases].
The ability of the synthesized compounds of germanium with bioligands to affect the biosynthesis and activity of alpha-amylase and alpha-L-rhamnosidase has been studied. It was established the most complexes tested induced biosyntheis of alpha-amylase of Bacillus subtilis 147 (119-252%) with the exception of Pam (Pyracetam) and II (Ge-nicotinic-citric acid). At the same time the biosynthesis of alpha-amylase of Bacillus licheniformis 234 and alpha-L-rhamnosidase of Penicillium commune was inhibited by a number of synthesized compounds. The complexes IV (Ge-malonic acid) and VIII (Ge-nicotinamide-malonic acid) did not exert any effect on the biosynthesis of alpha-amylase however complex IV stimulated alpha-L-rhamnosidase biosynthesis on the 3rd day of producer cultivation. The study of influence of the studied germanium compounds on the activity of alpha-amylase and alpha-L-rhamnosidase gives every reason to suppose that they are the inhibitors of the above-mentioned enzymes.
L D
LD
Varbanets
O N
ON
Rzaeva
E V
EV
Avdiiuk
I I
II
Seĭfullina
E E
EE
Martsinko
A G
AG
Pesaroglo
D001407:Bacillus / Q000187:drug effects / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005857:Germanium / Q000737:chemistry / Q000494:pharmacology*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D000516:alpha-Amylases / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism
D004791:Enzyme Inhibitors; D008024:Ligands; D009942:Organometallic Compounds; D005857:Germanium; D006026:Glycoside Hydrolases; D000516:alpha-Amylases; C501919:alpha-amylase, Bacillus licheniformis; C022525:alpha-L-rhamnosidase