The control of impurities in chlortalidone using a reversed-phase stationary phase.
A reversed-phased liquid chromatographic method for the control of impurities of nine impurities in Chlortalidone drug substance is presented. The method is sufficiently sensitive to quantify down to the level of 0.0015 per cent equivalent to a concentration of 15 microg/ml.
Douville
V
V
Council of Europe, F-67029 Strasbourg, France.
Keller
E
E
Lambertz
K
K
Lodi
A
A
Miller
J H M
JH
D000959:Antihypertensive Agents / Q000032:analysis / Q000737:chemistry; D002752:Chlorthalidone / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004340:Drug Contamination / Q000517:prevention & control*; D004355:Drug Stability; D015394:Molecular Structure; D015203:Reproducibility of Results
D000959:Antihypertensive Agents; D002752:Chlorthalidone