A new piperazine-2,5-dione from the marine fungus Gliocladium sp.
A new piperazine-2,5-dione, named gliocladride, was isolated from marine fungus Gliocladium sp. The structure was established on the basis of spectral data, and the stereochemical assignments were made by 1H NMR spectrum and chiral HPLC of the hydrolyzed compound. Gliocladride showed a cytotoxic effect with an IC50 value of 3.86 microg/ml against human A375-S2 melanoma cell line.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China.
Yao
Y
Yao
Li
L
Tian
Jia-Qing
JQ
Cao
Yue-Hu
YH
Pei
D000596:Amino Acids / Q000737:chemistry; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D045744:Cell Line, Tumor; D004121:Dimethyl Sulfoxide; D004354:Drug Screening Assays, Antitumor; D020462:Gliocladium / Q000737:chemistry*; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010879:Piperazines / Q000302:isolation & purification* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013778:Tetrazolium Salts; D013844:Thiazoles; D014750:Vincristine / Q000494:pharmacology
D000596:Amino Acids; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D010879:Piperazines; D013778:Tetrazolium Salts; D013844:Thiazoles; C522365:gliocladride; D014750:Vincristine; C022616:thiazolyl blue; D004121:Dimethyl Sulfoxide