TGFBIp/betaig-h3 protein: a versatile matrix molecule induced by TGF-beta.
TGFBIp/betaig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-beta. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/betaig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/betaig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation.
Cell and Matrix Research Institute, Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, 101 Dongin-Dong, Jung-gu, Daegu 700-422, Republic of Korea.
Narendra
N
Thapa
Byung-Heon
BH
Lee
In-San
IS
Kim
D000818:Animals; D003317:Corneal Dystrophies, Hereditary / Q000235:genetics / Q000503:physiopathology; D005109:Extracellular Matrix / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000503:physiopathology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology; D000099222:betaIG-H3 Protein
D016326:Extracellular Matrix Proteins; D016212:Transforming Growth Factor beta; D000099222:betaIG-H3 Protein