Comparison of excretory urographic contrast effects of dimeric and monomeric non-ionic iodinated contrast media in dogs.
In excretory urography, the osmolarity of contrast media has rarely been treated as important in veterinary medicine. In this study, the contrast effect of two contrast media (monomeric iohexol and dimeric iodixanol) in the renal cortex and aorta were compared using computed tomography (CT). Five beagle dogs were used and the study employed a cross-over method for each contrast media. The results showed that there was no difference between the media in the aorta, but iodixanol showed higher CT value and a longer contrast effect than iohexol in the renal cortex, in spite of having the same iodine dosage. It is believed that iodixanol, with its low osmolarity, is diluted less by osmotic diuresis than monomeric iohexol. It is important to consider the osmolarity of the contrast media when evaluating the contrast effect, and it is essential to use the same contrast media for each examination, or the renal excretory speed will be under/overestimated.
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-Sen 11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.
Miori
M
Kishimoto
Kazutaka
K
Yamada
Asuka
A
Watanabe
Kenji
K
Miyamoto
Toshiroh
T
Iwasaki
Yoh-Ichi
Y
Miyake
D000818:Animals; D003287:Contrast Media; D018592:Cross-Over Studies; D004285:Dogs / Q000378:metabolism / Q000502:physiology*; D007472:Iohexol / Q000493:pharmacokinetics; D007672:Kidney Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism; D009994:Osmolar Concentration; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000662:veterinary*; D014283:Triiodobenzoic Acids / Q000493:pharmacokinetics; D014567:Urography / Q000379:methods / Q000662:veterinary
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C044834:iodixanol