Neurite outgrowth: a flick of the wrist.
A new study has shown that, near the tip of a growing axon, dephosphorylation of the microtubule-associated protein Doublecortin is controlled by protein phosphatase 1 and its regulator spinophilin. This results in spatially regulated microtubule bundling within the axon and more efficient axon outgrowth.
Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Leif
L
Dehmelt
Shelley
S
Halpain
D000818:Animals; D000089622:Doublecortin Domain Proteins; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D016501:Neurites / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism; D010766:Phosphorylation
D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides