[Expressions and significances of EGFR, C-erbB2 and Ki-67 in nasal squamous cell carcinomas].
OBJECTIVE
To study the expressions of epidermal growth factor receptor (EGFR), C-erbB2 and Ki-67 in nasal squamous cell carcinomas (SCC) and investigate their clinicopathological significances in pathogenesis and development of this disease.


METHODS
Immunohistochemical technique (SP staining method) was used to detect the expressions of EGFR, C-erbB2 and Ki-67 in 31 cases of SCC and 17 cases of nasal inverted papilloma (IP) and 12 cases of nasal polyp tissues (NP).


RESULTS
Expression rates of EGFR and Ki-67 in SCC of nasal cavity and paranasal sinuses were significantly higher than that in IP (P < 0.05, P < 0.01) and NP (P < 0.05, P < 0.01) respectively. Expression of C-erbB2 was significantly higher in SCC than that in NP (P < 0.05). But the expressions of all the three biological markers have no significant differences among the groups of well, moderately and poorly differentiated of squamous cell carcinomas.


CONCLUSIONS
The expression of EGFR protein may be activated in the early stage of pathogenesis of nasal squamous cell carcinomas. Expression of C-erbB2 may be associated with the pathogenesis and development of nasal carcinomas. Immunohistochemical features of Ki-67 may be used as an objective index to reflect the biological behaviour of tumor arising from nasal cavity and paranasal sinuses. But all of the expressions of all the three biological markers were not associated with pathological histological gradings.
Department of Otorhinolaryngology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.
Jing
J
Li
Baohua
B
Wang
Lei
L
Guo
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D055815:Young Adult
D066246:ErbB Receptors; D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; C512478:EGFR protein, human; C508053:ERBB2 protein, human