Promising ternary dry powder inhaler formulations of cromolyn sodium: formulation and in vitro-in vivo evaluation.
Glucose monohydrate and sorbitol were evaluated as alternative carriers to á-lactose monohydrate in dry powder inhalations. Cromolyn sodium (CS) - carrier binary formulae were prepared and tested in vitro by aerosolization via a twin stage impinger using three types of inhaler devices; Spinhaler, Aerolizer and Handihaler. Glucose monohydrate and sorbitol-containing formulae that were inhaled via a Handihaler showed significantly higher drug fine particle fractions (P<0.001) than that of the same formulae aerosolized via other devices. Upon storage of the prepared formulae under uncontrolled humidity, that may be encountered during storage and use, marked reductions in these fractions were observed. Incorporation of an optimum Aerosil 200 concentration, as a ternary component, minimized this effect. A urinary excretion pharmacokinetic method was used to evaluate the bioavailability of the selected ternary formulae, inhaled via a Handihaler, relative to the marketed Intal Spincaps, inhaled via a Spinhaler. It was found that the relative bioavailability percentages of the developed formulae were more than twice that of the marketed one suggesting possible future utilization of these more effective ternrry formulae using the more efficient Handihaler inhaler device.
Department of Pharmaceutics and Industrial pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Ahmed Abd
AA
Elbary
Hanan M
HM
El-laithy
Mina I
MI
Tadros
D000328:Adult; D000336:Aerosols; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004205:Cromolyn Sodium / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004339:Drug Compounding; D004356:Drug Storage; D005079:Excipients; D005947:Glucose / Q000737:chemistry; D006801:Humans; D006813:Humidity; D007785:Lactose / Q000737:chemistry; D008168:Lung / Q000378:metabolism; D008297:Male; D011208:Powders; D013012:Sorbitol
D000336:Aerosols; D018927:Anti-Asthmatic Agents; D005079:Excipients; D011208:Powders; D013012:Sorbitol; D005947:Glucose; D007785:Lactose; D004205:Cromolyn Sodium