Diagnostic value of homocysteine, C-reactive protein and bilirubin for coronary artery disease.
We evaluated 3 new markers for coronary artery disease (CAD) [bilirubin, total homocysteine (t-Hcy) and high-sensitivity C-reactive protein (hs-CRP)] in 319 patients with chest pains divided into 2 groups based on coronary angiography: CAD group (n = 262) and non-CAD group (n = 57). A control group consisted of 50 healthy subjects. t-Hcy had the highest diagnostic value for diagnosis of angiographically documented patients; bilirubin had the lowest. The sensitivities and specificities (based on ROC curves) of bilirubin, hs-CRP and t-Hcy were 70.9%, 50% and 76.8% respectively, and 40.4%, 80.7% and 70.2% respectively. We conclude that serum bilirubin levels cannot identify people at risk of CAD and t-Hcy and hs-CRP may be stronger markers.
Department of Biochemistry, Gaziantep University Medical School, Gaziantep, Turkey. necatyilmaz@hotmail.com
N
N
Yilmaz
H K
HK
Ciçek
A
A
Celik
I
I
Meram
R
R
Kocabas
V
V
Davutoglu
D000704:Analysis of Variance; D019540:Area Under Curve; D001663:Bilirubin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D002637:Chest Pain / Q000209:etiology; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D014421:Turkey
D015415:Biomarkers; D006710:Homocysteine; D002097:C-Reactive Protein; D001663:Bilirubin