Coagulation disorder as a prognostic factor for patients with colorectal perforation.
BACKGROUND
Although sepsis after surgery for colorectal perforation frequently results in severe coagulation disorders and consequent death of the patient, the correlation between coagulation abnormalities and postoperative mortality of colorectal perforation has not been clarified.


METHODS
The medical records of 101 consecutive patients receiving surgery for colorectal perforations between January 1994 and July 2006 were retrospectively reviewed. The abnormalities of preoperative laboratory data reflecting coagulation disorders and other possible risk factors were analyzed by univariate and multivariate analysis.


RESULTS
Prolonged prothrombin time and activated partial thromboplastin time significantly correlated with a poor prognosis (both P < 0.001). Among the several risk factors analyzed, only the presence of coagulation disorders was an independent predictive factor of postoperative mortality.


CONCLUSIONS
Prolonged prothrombin time and activated partial thromboplastin time are useful prognostic factors for predicting the surgical outcome for patients with colorectal perforation.
Department of Surgery, Yaizu City Hospital, 1000 Dobara, Yaizu, Japan.
Kazushige
K
Kawai
Takeyuki
T
Hiramatsu
Ryo
R
Kobayashi
Naoki
N
Takabayashi
Yukio
Y
Ishihara
Ko
K
Ohata
Hirotaka
H
Niwa
Junji
J
Yasuike
Hiroki
H
Tanaka
Mitsutoshi
M
Kimura
Junichi
J
Shindoh
D000368:Aged; D001778:Blood Coagulation Disorders / Q000150:complications*; D003108:Colonic Diseases / Q000150:complications* / Q000401:mortality* / Q000601:surgery; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000150:complications* / Q000401:mortality* / Q000601:surgery; D008297:Male; D011379:Prognosis; D012002:Rectal Diseases / Q000150:complications* / Q000401:mortality* / Q000601:surgery; D012189:Retrospective Studies