Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin.
Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA.
Annaleise R
AR
Howard-Jones
Ryan G
RG
Kruger
Wei
W
Lu
Junhua
J
Tao
Catherine
C
Leimkuhler
Daniel
D
Kahne
Christopher T
CT
Walsh
D000215:Acylation; D000217:Acyltransferases / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D006031:Glycosylation; D016695:Glycosyltransferases / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D017334:Teicoplanin / Q000737:chemistry* / Q000378:metabolism
D017334:Teicoplanin; D000217:Acyltransferases; D016695:Glycosyltransferases