[Study of the Shenshuaining dispersible tablets in treating chronic renal failure rats induced by adenine].
OBJECTIVE
To observe the effect of Shenshuaining dispersible tablets in treating chronic renal failure (CRF) rats.


METHODS
Seventy-two Sprague-Dawley rats were randomly divided into normal control group, model control group, Niaoduqing group, Shenshuaining dispersible tablets group (high, middle and low dose). Model of CRF was constnucted by feeding the rats with feed containing 0.5% adenine. After 7 weeks, renal function, albumin (Alb), blood routine, blood electrolyte were detected and general status, changes of the kidney tissue were observed.


RESULTS
Compared with normal rats, the levels of serum blood urea nitrogen (BUN), creatinine (Cr) were markedly elevated in CRF rats, while the levels of Alb markedly failed. The serum potassium, natrium and phosphorus contents were significantly increased, the serum calcium contents were significantly decreased. The levels of red blood cells (RBC), hemoglobin and haematocrit were significantly failed. The CRF rats' kidney indexes were increased and appeared abnormity under pathology inspection. Shenshuaining dispersible tablets could markedly ameliorate above indexes.


CONCLUSIONS
Shenshuaining dispersible tablets can treat CRF through effectively ameliorating the CRF rats' renal function, regulating the electrolyte turbulence, increasing the levels of Alb and ameliorate anemia and pathological changes of the kidney tissue.
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Yun
Y
Ma
Lian-bin
LB
Hou
Wei
W
Xiao
D000225:Adenine; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004906:Erythrocyte Count; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D007677:Kidney Function Tests; D008297:Male; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013607:Tablets
D004365:Drugs, Chinese Herbal; C532547:Shenshuaining; D013607:Tablets; D003404:Creatinine; D000225:Adenine