Is clopidogrel beneficial following coronary bypass surgery?
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether clopidogrel is superior to aspirin in preventing adverse events post coronary arterial bypass grafting. Altogether 220 papers were found using the reported search, of which four presented the best evidence to answer the clinical question. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses of these papers are tabulated. We conclude that if aspirin is not tolerated, clopidogrel is an acceptable alternative, but there is no strong evidence that clopidogrel is superior to aspirin postcoronary surgery.
Nagarajan
Darbhamulla V
DV
Department of Cardiology, Stepping Hill Hospital, Stockport, Manchester, UK.
Lewis
Philip S
PS
Dunning
Joel
J