Status of uric acid management in hypertensive subjects.
Hyperuricemia in hypertensive subjects has been considered one of risk factors of cardiovascular diseases. We investigated the status of uric acid management in 799 hypertensive subjects (432 females and 367 males; mean age 70.9 years) managed by 43 doctors (19 cardiologists and 24 noncardiologists; 25 private practice doctors and 18 hospital doctors). The serum uric acid level was available in 85.7% of the patients. This availability was equivalent regardless of facility size, and more cardiologists than noncardiologists monitored this information. The prevalence of hyperuricemia was 17.5% and was higher in men and in patients with high triglyceridemia, left ventricular hypertrophy, renal dysfunction, proteinuria, and smokers, but was not higher in subjects with chronic heart failure, diabetes mellitus, and those with prescriptions for diuretics and beta-blockers. The average serum uric acid level was higher in men and patients with chronic heart failure, renal dysfunction, high triglyceridemia, low high-density cholesterolemia, smokers, and subjects prescribed beta-blockers. Fifty percent of hyperuricemic patients were medicated, and 48.6% of them cleared the uric acid target level (6 mg/dL). No differences were observed in the treatment rate or the achievement rate of the target between genders, concurrent diseases, and physician specialties. Although doctors, especially cardiologists, have a high concern for the serum uric acid level, they do not intervene intensively, and specific treatment for individual patterns is not routinely given. Thus, more attention to uric acid management is necessary in hypertensive subjects to prevent cardiovascular diseases.
Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan. yasutaka@grape.med.tottori-u.ac.jp
Yasutaka
Y
Yamamoto
Koichi
K
Matsubara
Go
G
Igawa
Yasuhiro
Y
Kaetsu
Shinobu
S
Sugihara
Takashi
T
Matsuura
Fumihiro
F
Ando
Kazuhiko
K
Sonoyama
Toshihiro
T
Hamada
Kazuhide
K
Ogino
Osamu
O
Igawa
Chiaki
C
Shigemasa
Ichiro
I
Hisatome
D000368:Aged; D000369:Aged, 80 and over; D002309:Cardiology / Q000706:statistics & numerical data; D003430:Cross-Sectional Studies; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D033461:Hyperuricemia / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D007325:Institutional Practice / Q000706:statistics & numerical data; D007564:Japan / Q000453:epidemiology; D008297:Male; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D011331:Private Practice / Q000706:statistics & numerical data; D014527:Uric Acid / Q000097:blood*; D014528:Uricosuric Agents / Q000627:therapeutic use; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D004791:Enzyme Inhibitors; D014528:Uricosuric Agents; D014527:Uric Acid; D014969:Xanthine Oxidase