[Sensory evaluation test: odor component analysis and endotoxin content of Krestin and Carbocrin (generic drug) to compare palatability].
We conducted a sensory evaluation test to demonstrate the difference in palatability between Krestin and Carbocrin (generic drugs). In addition,we analyzed the odorous components and endotoxin contents of the two products to clarify the difference in physicochemical properties. In the sensory evaluation test, questions were asked on the odor, taste, feeling on the tongue, and overall evaluation, to find out which is easier to swallow. Krestin is significantly superior to Carbocrin, showing a clear difference in palatability between the two products. In odor component analysis, chemicals estimated to be n-heptane and 4-methyl-3-penten-2-one or its isomer (ketone containing 6-carbon double bonding) were detected. In addition, endotoxin content was also different between the two products. According to the above results, Carbocrin is definitely different from Krestin. Prior to administration, it is necessary to give this information to patients and obtain consent before use.
Dept.of Surgery, Yokohama Ekisaikai Hospital.
Yasuhiko
Y
Miura
Masaru
M
Miura
Shigeharu
S
Komatsu
Toshimichi
T
Takahashi
Shinji
S
Togo
D000970:Antineoplastic Agents / Q000737:chemistry*; D016568:Drugs, Generic / Q000737:chemistry*; D004731:Endotoxins / Q000032:analysis*; D005069:Evaluation Studies as Topic; D006536:Heptanes / Q000032:analysis; D006801:Humans; D009812:Odorants; D011509:Proteoglycans / Q000737:chemistry*; D012684:Sensory Thresholds / Q000502:physiology; D013649:Taste
D000970:Antineoplastic Agents; D016568:Drugs, Generic; D004731:Endotoxins; D006536:Heptanes; D011509:Proteoglycans; C010770:polysaccharide-K; C028618:n-heptane