Involvement of glutathione in puberty and FSH release.
Administration of glutathione subcutaneously to immature female (age and weight matched) rats brings about a pre-ponement of puberty. A significant increase in pituitary, ovaries and uterine mass was observed in the experimental rats. Further, a considerable increase in pituitary FSH levels was also observed after intraventricular injection of glutathione in ovariectomized-steroid primed rats. Intraventricular administration of L-buthionine SR sulfoxamine produced a significant decrease in plasma FSH levels in intact male rats. These studies demonstrate the neuroendocrine role of glutathione on gonadotropins, specifically in relation to FSH release.
Vali Pasha
K
K
Department of Biochemistry, Nizam's Institute of Medical Sciences, Hyderabad 500482, AP, India. kotwal4pasha@yahoo.co.in
D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D019328:Buthionine Sulfoximine / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism / Q000502:physiology*; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D010052:Ovariectomy; D010053:Ovary / Q000187:drug effects / Q000502:physiology; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012741:Sexual Maturation / Q000502:physiology*; D014599:Uterus / Q000187:drug effects / Q000502:physiology
D000963:Antimetabolites; D019328:Buthionine Sulfoximine; D005640:Follicle Stimulating Hormone; D005978:Glutathione