Isolation and characterisation of bioactive isoflavonoids from the roots of Dalbergia horrida.
The roots of Dalbergia horrida yielded two new isoflavanones, Dalhorridin (I) - 5,5'-dihydroxy-3',4'-methylenedioxy-5''-prenyl-6'',6''-dimethyl-dihydropyrano(2'',3'' : 7,8)-isoflavanone and Dalhorridinin (II) - 5,7,5'-trihydroxy-3',4'-methylenedioxy-8-[5-methyl-2-(2-hydroxyisopropyl)-1,4-hexadienyl]isoflavanone along with two known isoflavones, Dalspinin and Dalspinosin. Preliminary biological screening of the enriched extract revealed that it showed analgesic, anti-inflammatory, CNS depressant and mild anti-bacterial properties.
Narayanan
Manoj C
MC
Pelican Biotech and Chemical Labs, 415-A, Vayalar P.O., Alappuzha District, Kerala - 688 536, India.
Rao
Priya R
PR
Shanmugam
Nagarajan N
NN
Gopalakrishnan
Sethuraman M
SM
Devi
Kshama
K
D019342:Acetic Acid; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002351:Carrageenan; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D035782:Dalbergia; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002492:Central Nervous System Depressants; D007529:Isoflavones; D010936:Plant Extracts; D002351:Carrageenan; D019342:Acetic Acid