Central and peripheral cardiovascular, ventilatory, and motor effects of trout urotensin-II in the trout.
Urotensin-II (U-II) was originally considered to be exclusively the product of the caudal neurosecretory system (CNSS) of teleost fish, but it has now been demonstrated that U-II is widely expressed in peripheral tissues and nervous structures of species from lampreys to mammals. However, very little is known regarding the physiological effects of this peptide in its species of origin. In the present review, we summarize the most significant results relating to the cardiovascular, ventilatory, and motor effects of centrally and peripherally administered synthetic trout U-II in our experimental animal model, the unanesthetized trout Oncorhynchus mykiss. In addition, we compare the actions of U-II with those of other neurohormonal peptides, particularly with the actions of urotensin-I, a 41-amino acid residue peptide paralogous to corticotropin-releasing hormone that is co-localized with U-II within neurons of the CNSS.
Le Mével
Jean-Claude
JC
INSERM U650, Laboratoire de Traitement de l'Information Médicale, Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale, 22 Avenue Camille Desmoulins, CS 93837, 29238 Brest Cedex 3, France. jean-claude.lemevel@univ-brest.fr
Lancien
Frédéric
F
Mimassi
Nagi
N
Leprince
Jérôme
J
Conlon
J Michael
JM
Vaudry
Hubert
H
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects*; D002490:Central Nervous System / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects*; D017686:Oncorhynchus mykiss / Q000502:physiology*; D012137:Respiratory System / Q000187:drug effects*; D014579:Urotensins / Q000494:pharmacology*
D014579:Urotensins; C029676:urotensin I; C029677:urotensin II