Differences in (-)citronellal binding to various odorant receptors.
To test the hypothesis that olfactory receptors (ORs) recognize different molecular features of odor molecules termed "odotypes", we studied receptor-ligand interactions of two human and two mouse ORs, recognizing (-)citronellal. Structurally similar receptors provide identical binding pockets (OLFR43, OR1A1, and OR1A2), and have comparable EC(50) values. Other ORs with lower sequence identity bind (-)citronellal in a different way, leading to different EC(50) values.
Stary
Anna
A
Institute for Theoretical Chemistry, University of Vienna, Waehringer Strasse 17, A-1090 Vienna, Austria. a9827228@unet.univie.ac.at
Suwattanasophon
Chonticha
C
Wolschann
Peter
P
Buchbauer
Gerhard
G
D000080462:Acyclic Monoterpenes; D000447:Aldehydes / Q000737:chemistry* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D016384:Consensus Sequence; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D039821:Monoterpenes / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D018035:Receptors, Odorant / Q000737:chemistry* / Q000378:metabolism
D000080462:Acyclic Monoterpenes; D000447:Aldehydes; D039821:Monoterpenes; D018035:Receptors, Odorant; C108217:citronellal