Symptoms of cutaneous sensitivity pre-treatment and post-treatment: results from the rizatriptan TAME studies.
The presence of cutaneous allodynia may predict response to triptans. Identical randomized double-blind studies were conducted comparing the efficacy of rizatriptan 10 mg or placebo administered within 1 h of headache onset, while pain was mild. The primary endpoint was freedom from pain at 2 h. Presence of symptoms suggesting cutaneous sensitivity (SCS) at baseline and at 2 h post-treatment was recorded. Before treatment, 29% of rizatriptan patients and 22% of placebo patients reported SCS. At 2 h, the percentage of patients with SCS was significantly decreased with rizatriptan. The presence of SCS pre-treatment was not predictive of response to rizatriptan. Most patients with SCS at 2 h were non-responders. Early treatment with rizatriptan significantly reduced the percentage of patients with SCS at 2 h. The presence of SCS at baseline did not predict pain-free response, but presence of SCS at 2 h correlated with lack of a 2-h pain-free response.
Banyan Group Inc, Springfield, MO 65807, USA. rcady@banyangroupinc.com
R
R
Cady
V
V
Martin
A
A
Mauskop
A
A
Rodgers
C  M
C
Hustad
K  E
K
Ramsey
F
F
Skobieranda
D000328:Adult; D015897:Comorbidity; D004311:Double-Blind Method; D005260:Female; D006261:Headache / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D006930:Hyperalgesia / Q000188:drug therapy* / Q000453:epidemiology*; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy* / Q000453:epidemiology*; D015990:Placebo Effect; D015995:Prevalence; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D014110:Touch; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D014363:Tryptamines / Q000627:therapeutic use*; D014481:United States / Q000453:epidemiology
D017366:Serotonin Receptor Agonists; D014230:Triazoles; D014363:Tryptamines; C093622:rizatriptan