5% topical imiquimod tolerance in transplant recipients.
BACKGROUND
Topical imiquimod is a new immunomodulator agent approved for genital warts, actinic keratosis (AK) or carcinoma, occurring in immunocompetent patients.


OBJECTIVE
This study aimed to assess the safety and efficacy of imiquimod for the treatment of warts, AK and bowenoid papulosis (BP) in transplant patients.


METHODS
24 transplant patients (18 kidney, 4 kidney-pancreas and 2 heart) were included in this retrospective study conducted between June 2000 and February 2003 at the department of dermatology of 3 hospitals. Imiquimod cream was applied 3 times a week over a median period of 9 weeks.


RESULTS
Graft function was not altered under therapy. Local tolerance was excellent. Complete responses were observed in 1 patient (1/12) with cutaneous warts and 1 (1/6) with AK. Two patients of 3 with BP had total clearance of their lesions. Partial responses were observed in 3 of the 6 AK-treated patients, 5 of 12 patients with cutaneous warts and 1 of 2 patients with anogenital warts.


CONCLUSIONS
Imiquimod 5% cream is a promising, well-tolerated therapy for warts, AK and BP in transplant recipients.
Department of Dermatology, Saint-Louis Hospital, Paris, France.
Lilia
L
Ben M'barek
Amel
A
Mebazaa
Sylvie
S
Euvrard
Camille
C
Frances
Eric
E
Thervet
Patrice
P
Morel
Suzanne
S
Menasché
Christophe
C
Legendre
Celeste
C
Lebbe
D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use*; D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000634:Aminoquinolines / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D000077271:Imiquimod; D016867:Immunocompromised Host; D007642:Keratosis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000209:etiology; D014180:Transplantation / Q000009:adverse effects; D016896:Treatment Outcome; D014466:Ultraviolet Rays / Q000009:adverse effects; D014860:Warts / Q000188:drug therapy* / Q000209:etiology
D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000077271:Imiquimod