Trophic venous ulcers and their relationship with the immune status.
This paper describes the results of an original study into the systemic and local immunity in 25 patients with trophic venous ulcers. The authors discovered a number of significant parameters demonstrating the influence of the immune status on the formation of venous ulcers and tempo of their healing. They revealed previously unknown relationships between the immune status, clinical manifestations arid natural history of venous ulcers. Presented herein are the first results of the local use of the immunomodulator gepon and evidence for its efficacy in the treatment of chronic trophic venous ulcers.
Kirienko
A I
AI
Clinic of Faculty Surgery, Russian SMU, Moscow, Russia.
Ataullakhanov
R I
RI
Bogachev
V Iu
VIu
Bogdanets
L I
LI
Pichugin
A V
AV
Zhuravleva
O V
OV
D000328:Adult; D000368:Aged; D015415:Biomarkers; D016827:CD8 Antigens / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007871:Leg Ulcer / Q000188:drug therapy* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology*; D014647:Varicose Ulcer / Q000188:drug therapy* / Q000276:immunology*
D015415:Biomarkers; D016827:CD8 Antigens; D016207:Cytokines; D007155:Immunologic Factors; D009842:Oligopeptides; C523770:Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu