Early destructive lesions in the developing brain: clinical and electrographic correlates.
OBJECTIVE
Early brain insults can cause cavitary lesions including porencephaly (POR) and multicystic encephalopathy (MCE). The objective of this study was to investigate clinical and electrographic correlates associated to these types of destructive brain lesions.


METHODS
Patients with POR and MCE were selected and submitted to clinical and Video-EEG monitoring. The following variables were analyzed: demographic data, type of lesion, presence of gliosis, perinatal complications, epilepsy, brain atrophy, and presence and frequency of epileptiform discharges.


RESULTS
Twenty patients were included, 65% males, 35% females, ages ranging from 1 to 40 years, 14 with MCE and 6 with POR. Eighteen patients had hemiparesis, 19 had epilepsy (current or in the past), seven of them had refractory seizures, and 16 had epileptiform discharges. All patients with MCE had gliosis while only 2 with POR had it.


CONCLUSIONS
No correlation was observed between type of lesion and clinical and electrographical outcome. However, a positive correlation was observed between frequency of discharges and presence of brain atrophy, and between MCE and gliosis.
Low
Cristiane
C
UNIPETE - Unidade de Pesquisa e Tratamento das Epilepsias - Departamento de Neurologia e Neurocirurgia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
Garzon
Eliana
E
Carrete
Henrique
H
Vilanova
Luis Celso
LC
Yacubian
Elza Márcia T
EM
Sakamoto
Américo C
AC
D000293:Adolescent; D000328:Adult; D001284:Atrophy / Q000473:pathology; D020863:Central Nervous System Cysts / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004678:Encephalomalacia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D004827:Epilepsy / Q000209:etiology / Q000473:pathology; D005260:Female; D005911:Gliosis / Q000473:pathology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male