Nonlinear drift-diffusion model of gating in the fast Cl channel.
The dynamics of the open or closed state region of an ion channel may be described by a probability density p(x,t) which satisfies a Fokker-Planck equation. The closed state dwell-time distribution fc(t) derived from the Fokker-Planck equation with a nonlinear diffusion coefficient D(x) proportional to exp(-gamma(x)), gamma>0 and a linear ramp potential Uc(x), is in good agreement with experimental data and it may be shown analytically that if gamma is sufficiently large, fc(t) proportional to t(-2-nu) for intermediate times, where nu=U'c/gamma approximately -0.3 for a fast Cl channel. The solution of a master equation which approximates the Fokker-Planck equation exhibits an oscillation superimposed on the power law trend and can account for an empirical rate-amplitude correlation that applies to several ion channels.
Vaccaro
S R
SR
Department of Physics, University of Adelaide, Adelaide, South Australia, 5005, Australia. svaccaro@physics.adelaide.edu.au
D018118:Chloride Channels / Q000737:chemistry*; D002713:Chlorine / Q000737:chemistry*; D003198:Computer Simulation; D004058:Diffusion; D015640:Ion Channel Gating; D008390:Markov Chains; D008956:Models, Chemical; D008958:Models, Molecular; D017711:Nonlinear Dynamics; D016062:Porosity
D018118:Chloride Channels; D002713:Chlorine