Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome.
Leptin, particularly in its free form, is deeply involved in the regulation of energy balance. Insulin was suggested to influence plasmatic leptin levels and soluble leptin receptor in humans. However, this study indicates that metformin treatment, although improving insulin levels, does not exert a significant effect on either total leptin level or free leptin index in obese women with hyperinsulinemia and PCOS.
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
Daniela
D
Romualdi
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
Giuseppe
G
Campagna
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
Luigi
L
Selvaggi
"Oasi" Institute for Research, Troina, Italy.
Rosa
R
Cento
"Oasi" Institute for Research, Troina, Italy.
Caterina
C
Proto
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy; "Oasi" Institute for Research, Troina, Italy.
Antonio
A
Lanzone
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: maurizioguido@libero.it.
Maurizio
M
Guido
D000328:Adult; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008687:Metformin / Q000494:pharmacology*; D009765:Obesity / Q000097:blood* / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications
D007004:Hypoglycemic Agents; D007328:Insulin; D020738:Leptin; D008687:Metformin