Dicing with viruses: microRNAs as antiviral factors.
In plants and invertebrates, Dicer genes play a critical role against infections by RNA viruses. In this issue, Otsuka et al. (2007) report that Dicer mutant mice are hypersusceptible to infection by the RNA virus VSV.
Müller
Stefanie
S
Faculté des Sciences de la Vie, Université Louis Pasteur, F-67070 Strasbourg, France.
Imler
Jean-Luc
JL
D000818:Animals; D053487:DEAD-box RNA Helicases / Q000502:physiology*; D004722:Endoribonucleases / Q000502:physiology*; D035683:MicroRNAs / Q000502:physiology*; D034622:RNA Interference / Q000502:physiology*; D012327:RNA Virus Infections / Q000201:enzymology* / Q000517:prevention & control* / Q000821:virology; D043244:Ribonuclease III / Q000096:biosynthesis / Q000502:physiology*
D035683:MicroRNAs; D004722:Endoribonucleases; C509781:Dicer1 protein, mouse; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases