Mitochondrial DNA transcription: regulating the power supply.
In this issue of Cell, Park et al. (2007) describe the nuclear encoded protein MTERF3 as a negative regulator of mitochondrial DNA transcription initiation. This study highlights a mechanism by which mitochondrial DNA transcription (and therefore oxidative phosphorylation) may be regulated in response to alterations in the cell's physiological and metabolic demands.
Taylor
Robert W
RW
Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Newcastle University, Newcastle upon Tyne, UK.
Turnbull
Douglass M
DM
D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000473:pathology; D024101:Mitochondrial Proteins / Q000378:metabolism; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure; D009928:Organ Specificity; D014158:Transcription, Genetic
D004272:DNA, Mitochondrial; D024101:Mitochondrial Proteins