Pharmacological and chemical effects of cigarette additives.
We investigated tobacco industry documents and other sources for evidence of possible pharmacological and chemical effects of tobacco additives. Our findings indicated that more than 100 of 599 documented cigarette additives have pharmacological actions that camouflage the odor of environmental tobacco smoke emitted from cigarettes, enhance or maintain nicotine delivery, could increase the addictiveness of cigarettes, and mask symptoms and illnesses associated with smoking behaviors. Whether such uses were specifically intended for these agents is unknown. Our results provide a clear rationale for regulatory control of tobacco additives.
Semel Institute for Neuroscience and Human Behavior and the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-6968, USA. mrabinoff@mednet.ucla.edu
Michael
M
Rabinoff
Nicholas
N
Caskey
Anthony
A
Rissling
Candice
C
Park
D000818:Animals; D006801:Humans; D000641:Ammonia / Q000009:adverse effects / Q000032:analysis; D016739:Behavior, Addictive / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003071:Cognition / Q000187:drug effects; D004357:Drug Synergism; D004569:Electroencephalography; D005071:Evoked Potentials; D009538:Nicotine / Q000009:adverse effects / Q000378:metabolism; D018722:Nicotinic Agonists / Q000009:adverse effects / Q000032:analysis; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D019460:Tobacco Industry; D062789:Tobacco Products; D014028:Tobacco Smoke Pollution / Q000032:analysis; D014481:United States / Q000453:epidemiology
D000641:Ammonia; D009538:Nicotine; D018722:Nicotinic Agonists; D014028:Tobacco Smoke Pollution