Impact of empirical-therapy selection on outcomes of intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus.
This study compares beta-lactam and vancomycin among intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Patients who received vancomycin had higher infection-related mortality, even if they were switched to beta-lactam once culture results became available; this relationship persisted after logistic regression analysis controlling for clinical characteristics.
Lodise
Thomas P
TP
Albany College of Pharmacy, Albany, NY 12208-3492, USA. lodiset@acp.edu
McKinnon
Peggy S
PS
Levine
Donald P
DP
Rybak
Michael J
MJ
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015331:Cohort Studies; D004697:Endocarditis, Bacterial / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D015819:Substance Abuse, Intravenous / Q000150:complications*; D016896:Treatment Outcome; D014640:Vancomycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D008712:Methicillin