Papillary renal adenoma of distal nephron differentiation in a horse.
A 20-year-old thoroughbred mare had a mass in the right kidney. The mass was encapsulated with fibrous capsule and composed of variably-sized papillary projections lined by a single layer of flattened to cuboidal neoplastic epithelial cells with no cytological and nuclear atypia. Immunohistochemically, the neoplastic cells were broadly positive for cytokeratin AE1/AE3 and granular staining for alpha-1-antitrypsin was focally detected; this immunohistochemical property was similar to that of the normal distal nephron. From these results, this case was diagnosed as papillary renal adenoma of distal nephron differentiation.
Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan. kmatsuda@rakuno.ac.jp
Kazuya
K
Matsuda
Yousuke
Y
Kousaka
Natsuko
N
Nagamine
Nobuo
N
Tsunoda
Hiroyuki
H
Taniyama
D000236:Adenoma / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D017809:Fatal Outcome; D005260:Female; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D007150:Immunohistochemistry / Q000662:veterinary; D007680:Kidney Neoplasms / Q000473:pathology / Q000662:veterinary*; D009399:Nephrons / Q000473:pathology*