Muscle metabolic modulation by chronic hypoxia.
De Palma et al. published a research paper in which they describe the effect of chronic hypoxia on rat skeletal muscle metabolism by means of a comparative proteomic analysis (J. Proteome Res. 2007, 6(5), 1974-1984). For this, relatively young animals were used. In our communication, we note that, based on other literature, it is likely that the adaptive response of skeletal muscle to hypoxia attenuates with age.
Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. H.Gosker@pul.unimaas.nl
Harry R
HR
Gosker
Annemie M W J
AM
Schols
D000375:Aging; D000818:Animals; D006019:Glycolysis; D000860:Hypoxia; D018482:Muscle, Skeletal / Q000378:metabolism*; D009218:Myosins / Q000737:chemistry; D010100:Oxygen / Q000378:metabolism; D010641:Phenotype; D020033:Protein Isoforms; D040901:Proteomics / Q000379:methods; D051381:Rats; D013997:Time Factors; D014158:Transcription, Genetic
D020033:Protein Isoforms; D009218:Myosins; D010100:Oxygen