Minimizing side effects of systemic corticosteroids in children.
Corticosteroids are potent drugs used in management of various inflammatory and autoimmune disorders. The antiinflammatory effects of corticosteroids cannot however be separated from their metabolic effects. Children are more vulnerable to their side effects, particularly the effects on growth, immunity and adrenal suppression. It is essential for the treating physician to be aware of the side effects and the measures to be taken to minimize them. A side effect that is unique to children is growth suppression, which is helped by alternate day treatment. Administration of small doses of prednisolone (10-15 mg/day or velocity significantly. The potency of dexamethasone and betamethasone in suppressing growth is nearly 18 times higher than that of prednisolone. There is some evidence that the administration of growth hormone can reverse these changes.
Department of Pediatrics, Seth GS Medical College and KEM Hospital, Mumbai - 400012, India. ctdeshmukh@hotmail.com
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Deshmukh
D000309:Adrenal Insufficiency / Q000139:chemically induced; D000367:Age Factors; D002648:Child; D004334:Drug Administration Schedule; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006130:Growth Disorders / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008659:Metabolic Diseases / Q000139:chemically induced / Q000517:prevention & control; D010024:Osteoporosis / Q000139:chemically induced
D005938:Glucocorticoids