[Effect of fluorosis on the expression of basic fibroblast growth factor in rat incisors].
OBJECTIVE
To investigate the effects of overdose fluoride on the expression of basic fibroblast growth factor (bFGF) in rat incisors.


METHODS
Twenty Wistar rats were randomly divided into 2 groups: group I (control group) distilled water was given; group II (experimental group) 100 mg/L NaF was given. The rats were killed at the end of 8 th week. Immunohistochemical staining was used to study the expression of bFGF in rat incisors.


RESULTS
Immunohistochemical results demonstrated the presence of bFGF in ameloblasts, odontoblasts of rat incisors. The expression of bFGF was reduced in group II (P < 0.01).


CONCLUSIONS
Overdose fluoride inhibits the expression of bFGF and affects the interaction between dental epithelium and dental mesenchyme, which leads to the enamel demineralization.
Department of Cariology and Endodontology, School of Stomatology, Tongji University, Shanghai 200072, China.
Hui
H
Liu
Qiang
Q
Wang
Feng
F
Zhu
Ping-ping
PP
Luo
Tian-lin
TL
Liu
Xiao-ling
XL
Wei
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D009050:Fluorosis, Dental / Q000378:metabolism*; D007180:Incisor / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D016222:Fibroblast Growth Factor 2