[Up-regulation of MUC2 mucin gene in chronic rhinosinusitis].
OBJECTIVE
To investigate the expression of MUC2 in human sinus mucosa and compare the expression of MUC2 mRNAs in normal and in chronic sinus mucosa.


METHODS
Thirty-two chronic ethmoid sinusitis mucosa samples and 8 normal ethmoid sinus mucosa samples were obtained; RNAs were extracted from sinus mucosa, and fluorescent quantitative PCR was performed for MUC2.


RESULTS
The levels of MUC2 mRNAs in chronic rhinosinusitis were significantly increased compared with those in normal sinus mucosa.


CONCLUSIONS
This result suggest that up-regulation of MUC2 in chronic rhinosinusitis may play an important role in the pathogenesis of sinus hypersecretion in chronic rhinosinusitis.
Department of Otolaryngology-Head and Neck Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. xuekunhuang@163.com
Xuekun
X
Huang
Yuan
Y
Li
Peng
P
Li
Hong
H
Liu
Qintai
Q
Yang
Jin
J
Ye
Weijie
W
Xu
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D055262:Mucin-2 / Q000235:genetics / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism*; D012852:Sinusitis / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation
C524625:MUC2 protein, human; D055262:Mucin-2