Papillary renal adenoma of distal nephron differentiation in a horse.
A 20-year-old thoroughbred mare had a mass in the right kidney. The mass was encapsulated with fibrous capsule and composed of variably-sized papillary projections lined by a single layer of flattened to cuboidal neoplastic epithelial cells with no cytological and nuclear atypia. Immunohistochemically, the neoplastic cells were broadly positive for cytokeratin AE1/AE3 and granular staining for alpha-1-antitrypsin was focally detected; this immunohistochemical property was similar to that of the normal distal nephron. From these results, this case was diagnosed as papillary renal adenoma of distal nephron differentiation.
Matsuda
Kazuya
K
Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan. kmatsuda@rakuno.ac.jp
Kousaka
Yousuke
Y
Nagamine
Natsuko
N
Tsunoda
Nobuo
N
Taniyama
Hiroyuki
H
D000236:Adenoma / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D017809:Fatal Outcome; D005260:Female; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D007150:Immunohistochemistry / Q000662:veterinary; D007680:Kidney Neoplasms / Q000473:pathology / Q000662:veterinary*; D009399:Nephrons / Q000473:pathology*