Schwannoma of the breast: a case report and review of the literature.
Schwannoma arising within breast parenchyma is very rare. This report describes such a case in a 58-year-old woman. The tumor, which measured 4.4 x 3.5 x 2.1 cm, was painless, mobile and elastic-soft. Mammography showed a well-circumscribed, oval-shaped nodule without microcalcifications. At ultrasonography it appeared as a hypoechoic solid mass. Fine-needle cytology revealed several clusters of spindle cells indicative of a neoplasm of mesenchymal origin. Histological examination evidenced the characteristic morphological appearance of a schwannoma with Antoni A and Antoni B areas. A review of the 23 proven cases of breast schwannoma is included. The main differential diagnostic findings are also discussed.
Institute of Pathologic Anatomy and Histology, Division of Cancer Research, Perugia Medical School, University of Perugia, Perugia, Italy. guidobellezza@virgilio.it
Guido
G
Bellezza
Tiziana
T
Lombardi
Paola
P
Panzarola
Angelo
A
Sidoni
Antonio
A
Cavaliere
Michele
M
Giansanti
D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002277:Carcinoma / Q000175:diagnosis; D003893:Desmin / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009442:Neurilemmoma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis; D014463:Ultrasonography
D003893:Desmin; D009363:Neoplasm Proteins; D009418:S100 Proteins