Organocatalytic conjugate addition of formaldehyde N,N-dialkylhydrazones to beta,gamma-unsaturated alpha-keto esters.
(1S,2R)-1-Aminoindan-2-ol-derived thioureas behave as efficient H-bonding organocatalysts for the nucleophilic conjugate addition of formaldehyde hydrazones to beta,gamma-unsaturated alpha-keto esters as enoate surrogates, affording the corresponding adducts in good yields and enantioselectivities.
Herrera
Raquel P
RP
Instituto de Investigaciones Químicas, CSIC-USe, c/ Américo Vespucio 49, Isla de la Cartuja, 41092 Seville, Spain, and Departamento de Química OrgAnica, Facultad de Química, Universidad de Sevilla, Apdo. de Correos No. 553, 41071 Seville, Spain.
Monge
David
D
Martín-Zamora
Eloísa
E
Fernandez
Rosario
R
Lassaletta
José M
JM