Neuroprotection during cardiac surgery.
Cerebral injury following cardiac surgery continues to be a significant source of morbidity and mortality after cardiac surgery. A spectrum of injuries ranging from subtle neurocognitive dysfunction to fatal strokes are caused by a complex series of multifactorial mechanisms. Protecting the brain from these injuries has focused on intervening on each of the various etiologic factors. Although numerous studies have focused on a pharmacologic solution, more success has been found with nonpharmacologic strategies, including optimal temperature management and reducing emboli generation.
Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA.
Hilary P
HP
Grocott
Kenji
K
Yoshitani
D050197:Atherosclerosis / Q000150:complications / Q000628:therapy; D001831:Body Temperature / Q000502:physiology; D003072:Cognition Disorders / Q000517:prevention & control*; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology / Q000628:therapy; D007036:Hypothermia, Induced; D015994:Incidence; D020766:Intracranial Embolism / Q000209:etiology / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D011673:Pulsatile Flow / Q000502:physiology; D020521:Stroke / Q000517:prevention & control*; D013997:Time Factors
D018696:Neuroprotective Agents