Screening versus routine practice in detection of atrial fibrillation in patients aged 65 or over: cluster randomised controlled trial.
OBJECTIVE
To assess whether screening improves the detection of atrial fibrillation (cluster randomisation) and to compare systematic and opportunistic screening.


METHODS
Multicentred cluster randomised controlled trial, with subsidiary trial embedded within the intervention arm.


METHODS
50 primary care centres in England, with further individual randomisation of patients in the intervention practices.


METHODS
14,802 patients aged 65 or over in 25 intervention and 25 control practices.


METHODS
Patients in intervention practices were randomly allocated to systematic screening (invitation for electrocardiography) or opportunistic screening (pulse taking and invitation for electrocardiography if the pulse was irregular). Screening took place over 12 months in each practice from October 2001 to February 2003. No active screening took place in control practices.


METHODS
Newly identified atrial fibrillation.


RESULTS
The detection rate of new cases of atrial fibrillation was 1.63% a year in the intervention practices and 1.04% in control practices (difference 0.59%, 95% confidence interval 0.20% to 0.98%). Systematic and opportunistic screening detected similar numbers of new cases (1.62% v 1.64%, difference 0.02%, -0.5% to 0.5%).


CONCLUSIONS
Active screening for atrial fibrillation detects additional cases over current practice. The preferred method of screening in patients aged 65 or over in primary care is opportunistic pulse taking with follow-up electrocardiography.


BACKGROUND
Current Controlled Trials ISRCTN19633732 [controlled-trials.com].
Fitzmaurice
David A
DA
Department of Primary Care and General Practice, University of Birmingham, Birmingham B15 2TT.
Hobbs
F D Richard
FD
Jowett
Sue
S
Mant
Jonathon
J
Murray
Ellen T
ET
Holder
Roger
R
Raftery
J P
JP
Bryan
S
S
Davies
Michael
M
Lip
Gregory Y H
GY
Allan
T F
TF
D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000453:epidemiology; D016000:Cluster Analysis; D004562:Electrocardiography; D004739:England / Q000453:epidemiology; D005194:Family Practice; D006801:Humans; D008403:Mass Screening / Q000379:methods; D009722:Nurse Practitioners; D015995:Prevalence; D011379:Prognosis