Cross-reactivity of non-Aspergillus fungal species in the Aspergillus galactomannan enzyme immunoassay.
The Aspergillus galactomannan enzyme-linked immunosorbant assay (EIA) has been demonstrated to facilitate rapid and sensitive detection of invasive aspergillosis. However, test specificity has not been fully evaluated in non-Aspergillus fungal species. Of 53 fungal isolates, cross-reactivity was observed with 5 non-Aspergillus spp.: Blastomyces dermatitidis, Nigrospora oryzae, Paecilomyces lilacinus, Penicillium chrysogenum, and Trichothecium roseum.
Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38103, USA.
Jessica R
JR
Cummings
Ginger R
GR
Jamison
Jan W
JW
Boudreaux
Merry J
MJ
Howles
Thomas J
TJ
Walsh
Randall T
RT
Hayden
D001228:Aspergillosis / Q000175:diagnosis; D001230:Aspergillus / Q000145:classification*; D003429:Cross Reactions; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D008351:Mannans / Q000145:classification*; D016533:Mycological Typing Techniques / Q000379:methods*; D009181:Mycoses / Q000175:diagnosis*; D012680:Sensitivity and Specificity
D008351:Mannans; C012990:galactomannan; D005690:Galactose