Mitochondrial dysfunction and Huntington disease.
Huntington disease (HD) is a chronic autosomal-dominant neurodegenerative disease. The gene coding Huntingtin has been identified, but the pathogenic mechanisms of the disease are still not fully understood. This paper reviews the involvement of mitochondrial dysfunction in pathogenesis of HD.
Zhang
Wei-Yan
WY
SooChow University School of Life Sciences; Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China; E-mail: zhqin5@hotmail.com.
Gu
Zhen-Lun
ZL
Liang
Zhong-Qin
ZQ
Qin
Zheng-Hong
ZH