Endocrine regulation of ageing.
Over the past 15 years it has become clear that mutations in genes that regulate endocrine signalling pathways can prolong lifespan. Lifespan can be increased by altered endocrine signalling in a group of cells or a single tissue, which indicates that crosstalk between tissues functions to coordinate ageing of the organism. These endocrine pathways might serve as targets for the manipulation of the ageing process and prevention of age-related diseases.
Joslin Diabetes Center and Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA. steven.russell@joslin.harvard.edu
Steven J
SJ
Russell
C Ronald
CR
Kahn
D000375:Aging / Q000502:physiology*; D000818:Animals; D004703:Endocrine System / Q000502:physiology*; D005966:Glucuronidase / Q000235:genetics / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000502:physiology; D000090265:Klotho Proteins; D008136:Longevity / Q000502:physiology; D015398:Signal Transduction
D007328:Insulin; D005966:Glucuronidase; D000090265:Klotho Proteins