Usefulness of the dopamine system-stabilizer aripiprazole for reducing morphine-induced emesis.
In the management of pain, nausea and vomiting are some of the most distressing adverse effects induced by opioids. In the present study, we investigated the effect of the dopamine system-stabilizer aripiprazole on morphine-induced emesis. Morphine induced retching and vomiting in a dose-dependent manner in ferrets. The emetic effect of morphine was significantly suppressed by pretreatment with either the dopamine receptor antagonist haloperidol or aripiprazole. These results suggest that the co-administration of aripiprazole may be useful for reducing the severity of morphine-induced emesis.
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Mitsuru
M
Shiokawa
Minoru
M
Narita
Atsushi
A
Nakamura
Kazuhiro
K
Kurokawa
Tadao
T
Inoue
Tsutomu
T
Suzuki
D000701:Analgesics, Opioid / Q000009:adverse effects*; D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D000068180:Aripiprazole; D005289:Ferrets; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D010879:Piperazines / Q000627:therapeutic use*; D015363:Quinolones / Q000627:therapeutic use*; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
D000701:Analgesics, Opioid; D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D017448:Receptors, Dopamine D2; D009020:Morphine; D000068180:Aripiprazole