Sedative effect of Centranthus longiflorus ssp. longiflorus in rats and the influence of adrenalectomy on its effect.
Sedative effect of the aqueous extract of Centranthus longiflorus ssp. longiflorus (Cle-1) on intact and adrenalectomized rats was investigated using a thiopental sleeping test to clarify the relationship of this effect on adrenal gland hormones, particularly glucocorticoids. Adrenal gland hormones were found to play an important role in inhibiting the sedative effect of the investigated drugs. It is clear, however, that these hormones are not glucocorticoids. Glucocorticoids were not responsible for shortening the sleep period.
Suleyman
Halis
H
Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Guvenalp
Zuhal
Z
Kizilkaya
Mehmet
M
Demirezer
L Omur
LO
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D005938:Glucocorticoids / Q000502:physiology; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D013874:Thiopental / Q000494:pharmacology; D028161:Valerianaceae; D014867:Water
D005938:Glucocorticoids; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D014867:Water; D013874:Thiopental