Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndrome.
A fourteen-year-old right-handed male with a history of attention deficit hyperactivity disorder (ADHD) presented with alternating hemichorea. Laboratory findings included elevated anticardiolipin IgG and anti-beta(2)-glycoprotein I IgG, which were consistent with primary antiphospholipid antibody syndrome. Positron emission tomography (PET) imaging revealed altered striatal metabolism in his left putamen while he was exhibiting right-sided hemichorea. His symptoms resolved on prednisone; however, his antiphospholipid antibody profile remained markedly abnormal despite being symptom-free for 26 months.
Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. Steve.wu@cchmc.org
Steve W
SW
Wu
Brent
B
Graham
Michael J
MJ
Gelfand
Ralph E
RE
Gruppo
Argirios
A
Dinopolous
Donald L
DL
Gilbert
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications; D002308:Cardiolipins / Q000276:immunology*; D002819:Chorea / Q000000981:diagnostic imaging* / Q000209:etiology / Q000276:immunology*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D009460:Neurologic Examination; D049268:Positron-Emission Tomography / Q000379:methods*; D053482:beta 2-Glycoprotein I / Q000276:immunology*
D002308:Cardiolipins; D007074:Immunoglobulin G; D053482:beta 2-Glycoprotein I; D019788:Fluorodeoxyglucose F18