Myocardial infarction in a young man with antiphospholipid syndrome and cocaine use.
The authors present a case of myocardial infarction in a 26-year-old man with antiphospholipid syndrome (APS) and a history of recent cocaine use. His only traditional cardiovascular risk was that he smoked. The authors propose that his cocaine use and APS brought about a potentially catastrophic cardiac event despite therapeutic anticoagulation. This was supported by the finding of normal coronary arteries on angiography despite both a significant regional wall motion abnormality on echocardiography and a significant rise in Troponin I. This case suggests the presence of a synergistic effect between cocaine and antiphospholipid antibodies.
Rheumatology Department, Southampton University Hospitals NHS Trust, Southampton, UK. emwilliams25@btinternet.co.uk
E L
EL
Williams
A L
AL
Endean
C J
CJ
Edwards
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications*; D019970:Cocaine-Related Disorders / Q000150:complications*; D017023:Coronary Angiography; D004452:Echocardiography; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology*; D019210:Troponin I / Q000097:blood
D000925:Anticoagulants; D019210:Troponin I