[Creatinine clearance and contrast nephropathy in patients with normal creatinine levels].
The main risk factor for contrast nephropathy is the presence of poor renal function. Plasma creatinine level is not a reliable measure of renal function as its value could lie within the normal range despite the presence of significant nephropathy. The purpose of this study was to evaluate the creatinine clearance rate as a predictor of contrast nephropathy in patients with a normal plasma creatinine level. The study included 273 consecutive patients with non-ST elevation acute coronary syndrome (NSTEACS) and a normal plasma creatinine level at admission who underwent coronary angiography. Patients who developed contrast nephropathy had a lower creatinine clearance rate at admission (66.3 mL/min vs. 83.4 mL/min; P<.001). A creatinine clearance rate < 80 mL/min had a sensitivity of 81% for predicting contrast nephropathy. Creatinine clearance should be measured routinely in patients with NSTEACS who are scheduled for coronary angiography.
Unidad Coronaria, Instituto Cardiovascular, Hospital Clínico San Carlos, Madrid, España. albertutor@hotmail.com
José A
JA
de Agustín
Rocío
R
Carda
María del C
Mdel C
Manzano
Borja
B
Ruiz-Mateos
Juan C
JC
García-Rubira
Antonio
A
Fernández-Ortiz
Isidre
I
Vilacosta
Carlos
C
Macaya
D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D003404:Creatinine / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012016:Reference Values
D003287:Contrast Media; D003404:Creatinine