From multifunctionalized poly(ethylene imine)s toward antimicrobial coatings.
Primary amine groups of branched poly(ethylene imine) (PEI) were functionalized with quaternary ammonium groups, alkyl chains of different length, allylic and benzylic groups in a one-step reaction, using a carbonate coupler. The structure of the obtained amphiphilic polymers was determined by means of 1H and 13C NMR spectroscopy. Depending on their hydrophilic/hydrophobic balance, the obtained polymers can be used as water-soluble disinfectants and for antimicrobial coating materials. The bactericidal properties of some of the amphiphilic polymers against Gram-negative and Gram-positive bacteria were investigated. Minimal inhibitory concentrations (log 4 reduction of bacterial growth) against Escherichia coli and Bacillus subtilis were determined in the range of 0.3-0.4 mg/mL and 0.03-0.04 mg/mL for water-soluble polymers. Glass slides coated with functionalized PEIs showed a reduction of colony forming units of at least 95%, at best 99.9%, against E. coli and B. subtilis.
DWI an der RWTH Aachen e.V. and Institute of Technical and Macromolecular Chemistry, RWTH Aachen, Pauwelsstrasse 8, D-52056 Aachen, Germany.
Nicolas
N
Pasquier
Helmut
H
Keul
Elisabeth
E
Heine
Martin
M
Moeller
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001672:Biocompatible Materials; D004926:Escherichia coli / Q000187:drug effects; D007097:Imines / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011095:Polyethylenes / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D007097:Imines; D011095:Polyethylenes; C505405:poly(ethylene imine)