Pathogenesis and clinical features of psoriasis.
Psoriasis, a papulosquamous skin disease, was originally thought of as a disorder primarily of epidermal keratinocytes, but is now recognised as one of the commonest immune-mediated disorders. Tumour necrosis factor alpha, dendritic cells, and T-cells all contribute substantially to its pathogenesis. In early-onset psoriasis (beginning before age 40 years), carriage of HLA-Cw6 and environmental triggers, such as beta-haemolytic streptococcal infections, are major determinants of disease expression. Moreover, at least nine chromosomal psoriasis susceptibility loci have been identified. Several clinical phenotypes of psoriasis are recognised, with chronic plaque (psoriasis vulgaris) accounting for 90% of cases. Comorbidities of psoriasis are attracting interest, and include impairment of quality of life and associated depressive illness, cardiovascular disease, and a seronegative arthritis known as psoriatic arthritis. A more complete understanding of underlying pathomechanisms is leading to new treatments, which will be discussed in the second part of this Series.
Dermatology Centre, Hope Hospital, University of Manchester, Manchester M6 8HD, UK. Electronic address: christopher.griffiths@manchester.ac.uk.
Christopher Em
CE
Griffiths
St John's Institute of Dermatology, Guy's Hospital Campus, King's College London, London, UK.
Jonathan Nwn
JN
Barker
D000818:Animals; D015897:Comorbidity; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D012934:Social Isolation