Controlled ovarian hyperstimulation: are we monitoring the appropriate sex-steroid hormones?
We prospectively evaluated the behavior of serum 17-hydroxyprogesterone (17-OHP), sex-steroid hormones, and C-reactive protein (CRP) levels in 27 patients during controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). While routine measurement of COH via serum 17-OHP may replace estradiol (E(2)) and progesterone levels, additional studies are needed to elucidate the ceiling level of serum 17-OHP beyond which intervention is required to prevent severe ovarian hyperstimulation syndrome.
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel; Ben Gurion University School of Medicine, Beer Sheva, Israel. Electronic address: raoulo@barzi.health.gov.il.
Raoul
R
Orvieto
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.
Eduard
E
Hod
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.
Michael
M
Volodarsky
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.
Roy
R
Homburg
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.
Jacob
J
Rabinson
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.
Simion
S
Meltcer
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood / Q000517:prevention & control; D010062:Ovulation Induction / Q000379:methods*; D011374:Progesterone / Q000097:blood*; D011446:Prospective Studies
D015415:Biomarkers; D011374:Progesterone; D004958:Estradiol; D019326:17-alpha-Hydroxyprogesterone; D002097:C-Reactive Protein