Proteomic analysis of peritoneal fluid in women with endometriosis.
This study aims to evaluate differences in the expression of proteins present in the peritoneal fluid (PF) of women with and without endometriosis. PF samples were subjected to two-dimensional gel electrophoresis; protein spots of interest were identified by liquid chromatography tandem mass spectrometry. Several molecules had aberrant expression in PF of women with endometriosis; they may be useful for a better understanding of the pathogenesis of this disease.
Reproductive Physiology Laboratory, St. Bartholomew's School of Medicine & Dentistry, Queen Mary University of London, United Kingdom.
Simone
S
Ferrero
David J
DJ
Gillott
Valentino
V
Remorgida
Paola
P
Anserini
Kit-Yi
KY
Leung
Nicola
N
Ragni
Jurgis G
JG
Grudzinskas
D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D002853:Chromatography, Liquid; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013058:Mass Spectrometry / Q000379:methods; D008597:Menstrual Cycle; D040901:Proteomics / Q000379:methods*; D016622:Silver Staining