Dicaprylyl maleate--an emerging cosmetic allergen.
Dicaprylyl maleate (DCM) has been reported rarely as a cause of allergic contact dermatitis. The objectives of this study were to identify patients from multiple centres with allergy to DCM in cosmetic products confirmed by patch testing and, in addition, to investigate the effect of testing with aged DCM. This is an international multicentre study of 22 patients with 26 reactions to products containing DCM. Patch testing was carried out to ingredients including DCM obtained from the manufacturer. Further testing was carried out with deliberately aged DCM in a sample of patients. 22 patients had clinical and positive patch test reactions at 4 days to a total of 26 cosmetic products containing DCM. 5 patients did not react to DCM prepared by the manufacturer from concurrent factory stock but did have positive reactions to a deliberately aged batch of DCM. DCM is an emerging cosmetic allergen. Testing with aged material yields a greater number of positive results. Co-operation between cosmetics manufacturers and clinicians is important in the identification of new allergens.
Department of Dermatology, Southampton University Hospitals Trust, Southampton, UK. hlotery@doctors.org.uk
Helen
H
Lotery
Stephen
S
Kirk
Michael
M
Beck
Ekaterina
E
Burova
Mary
M
Crone
Reginald
R
Curley
Anthony
A
Downs
Glenda
G
Hill
Helen
H
Horne
Nadia
N
Iftikhar
Christopher
C
Lovell
Ken
K
Malanin
David
D
Orton
Sheila
S
Powell
Jane
J
Sansom
Timothy
T
Sonnex
David
D
Todd
Simon
S
Tucker
Mark
M
Wilkinson
Adam
A
Haworth
D000328:Adult; D000368:Aged; D000485:Allergens / Q000009:adverse effects*; D003358:Cosmetics / Q000009:adverse effects* / Q000737:chemistry; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D004643:Emollients / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008298:Maleates / Q000009:adverse effects* / Q000737:chemistry; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods
D000485:Allergens; D003358:Cosmetics; D004643:Emollients; D008298:Maleates; C484947:dioctyl maleate