The functional neuroanatomy of maternal love: mother's response to infant's attachment behaviors.
BACKGROUND
Maternal love, which may be the core of maternal behavior, is essential for the mother-infant attachment relationship and is important for the infant's development and mental health. However, little has been known about these neural mechanisms in human mothers. We examined patterns of maternal brain activation in response to infant cues using video clips.


METHODS
We performed functional magnetic resonance imaging (fMRI) measurements while 13 mothers viewed video clips, with no sound, of their own infant and other infants of approximately 16 months of age who demonstrated two different attachment behaviors (smiling at the infant's mother and crying for her).


RESULTS
We found that a limited number of the mother's brain areas were specifically involved in recognition of the mother's own infant, namely orbitofrontal cortex (OFC), periaqueductal gray, anterior insula, and dorsal and ventrolateral parts of putamen. Additionally, we found the strong and specific mother's brain response for the mother's own infant's distress. The differential neural activation pattern was found in the dorsal region of OFC, caudate nucleus, right inferior frontal gyrus, dorsomedial prefrontal cortex (PFC), anterior cingulate, posterior cingulate, thalamus, substantia nigra, posterior superior temporal sulcus, and PFC.


CONCLUSIONS
Our results showed the highly elaborate neural mechanism mediating maternal love and diverse and complex maternal behaviors for vigilant protectiveness.
Noriuchi
Madoka
M
Laboratory of Cognitive Neuroscience, Department of Frontier Health Science, Division of Human Health Science, Graduate School of Tokyo Metropolitan University, Tokyo, Japan. ykikuchi@hs.tmu.ac.jp
Kikuchi
Yoshiaki
Y
Senoo
Atsushi
A
D001143:Arousal / Q000502:physiology; D001921:Brain / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D018730:Infant Behavior / Q000523:psychology*; D008149:Love; D008279:Magnetic Resonance Imaging; D008425:Maternal Behavior; D009034:Mother-Child Relations; D009415:Nerve Net / Q000502:physiology*; D009769:Object Attachment; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology