Oesophagectomy for squamous cell carcinoma: lessons from a decade of consecutive resections.
The aim of this study was to analyse the outcome following oesophageal resection for squamous cell carcinoma (SCC) in a large volume unit. Between 1987 and 1997, 166 patients with SCC underwent oesophagectomy. The outcomes and pathological characteristics of this cohort were then analysed. Operative mortality was 6% (10 patients). Anastomotic leak occurred in 11 (6.6%). A history of previous respiratory disease and anastomotic leak were independent predictors of early mortality (P=0.02). Pathological examination demonstrated the presence of stage I disease in 8, stage IIa in 58, stage IIb in 14 and stage III in 87 patients. Kaplan-Meier survival at 1, 3 and 5 years for all patients was 71.6%, 44.6% and 33.5%. Five-year survival was 87.5% for stage I, 47.1% for stage IIa, 27.4% for stage IIb and 14.5% for stage III. On multivariate analysis, pathological stage (P=0.001) and presence of involved lymph nodes were independent adverse predictors of survival (P<0.0001). In conclusion, oesophagectomy for SCC carries an acceptable risk, which is higher for those having a respiratory disease and those developing an anastomotic leak. The good survival observed in early pathological stages and the presence of long-term survivors amongst those with locally advanced disease are encouraging.
Thoracic Surgery Unit, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK.
Christos
C
Alexiou
Omar
O
Khan
Patrick
P
Onyeaka
Lynda
L
Beggs
Ellis
E
Morgan
David
D
Beggs