Altered urinary release of inositol phosphoglycan A-type in women with gestational diabetes mellitus.
OBJECTIVE
The mechanisms underlying overgrowth of adipose tissue in fetuses of women with gestational diabetes mellitus (GDM) are generally unknown. Inositol phosphoglycan A-type (A-IPG), a putative second messenger of insulin, was reported to regulate lipogenesis in adipose tissue. IPGs have recently been shown to increase during normal pregnancy, in maternal and fetal compartments.


METHODS
48 women with GDM and 23 healthy pregnant women were recruited for this cross-sectional study. Levels of A-IPG were assessed enzymatically in urinary specimens and correlated with clinical parameters.


RESULTS
A-IPG urinary release was lower in GDM patients (p < 0.01) and correlated positively with BMI (p < 0.01) and negatively with glycaemic control in the diabetic group (postprandial glycaemia and glycated haemoglobin, p < 0.01) in addition to a nearly significant correlation with birth weight (p = 0.08). Furthermore, a lower A-IPG urinary release was found in diabetic subjects with normal fasting glycaemia compared with those with poor fasting glycaemic control (p < 0.05).


CONCLUSIONS
An altered A-IPG urinary excretion occurs in GDM with a negative correlation with poor glycaemic control. Our data suggest an interesting potential role of this molecule in maternal metabolic control during pregnancy and, possibly, in fetal growth.
Scioscia
Marco
M
Department of Molecular Pathology, Molecular Medicine Unit, Royal Free and University College Medical School, London, UK. marcoscioscia@gmail.com
Kunjara
Sirilaksana
S
Gumaa
Khalid
K
Gomez Galan
Antonio M
AM
McLean
Patricia
P
Rodeck
Charles H
CH
Rademacher
Thomas W
TW
D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000652:urine*; D005260:Female; D005951:Glucose Tolerance Test; D038321:Glycemic Index; D006801:Humans; D007295:Inositol Phosphates / Q000652:urine*; D011134:Polysaccharides / Q000652:urine*; D011247:Pregnancy
D001786:Blood Glucose; D007295:Inositol Phosphates; D011134:Polysaccharides; C028039:inositol phosphate glycan