Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin.
Howard-Jones
Annaleise R
AR
Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, Massachusetts 02115, USA.
Kruger
Ryan G
RG
Lu
Wei
W
Tao
Junhua
J
Leimkuhler
Catherine
C
Kahne
Daniel
D
Walsh
Christopher T
CT
D000215:Acylation; D000217:Acyltransferases / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D006031:Glycosylation; D016695:Glycosyltransferases / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D017334:Teicoplanin / Q000737:chemistry* / Q000378:metabolism
D017334:Teicoplanin; D000217:Acyltransferases; D016695:Glycosyltransferases