[Pathophysiology and classitication of parathyroidism].
Hypoparathyroidism is characterized by decreased actions of parathyroid hormone (PTH) either by reduced secretion of or resistance to PTH. The understanding in the pathogenesis of hypoparathyroidism has been greatly increased by recent findings in genetic abnormalities of patients with hypoparathyroidism. A new classification of hypoparathyroidism based upon these genetic abnormalities is proposed, and a diagnostic approach to patients with hypoparathyroidism is summarized.
Endo
Itsuro
I
University of Tokushima Graduate School of Health Biosciences, Department of Medicine and Bioregulatory Sciences, Japan.
Matsumoto
Toshio
T
Fukumoto
Seiji
S
D002864:Chromogranins; D057167:Claudins; D003937:Diagnosis, Differential; D050990:GATA3 Transcription Factor / Q000235:genetics; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics; D006801:Humans; D006996:Hypocalcemia / Q000175:diagnosis / Q000209:etiology; D007011:Hypoparathyroidism / Q000145:classification* / Q000175:diagnosis / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics; D010281:Parathyroid Hormone / Q000172:deficiency; D044169:Receptors, Calcium-Sensing / Q000235:genetics; D050053:TRPM Cation Channels / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D000096927:AIRE Protein
D002864:Chromogranins; D057167:Claudins; D050990:GATA3 Transcription Factor; D019205:GTP-Binding Protein alpha Subunits, Gs; D008565:Membrane Proteins; D009687:Nuclear Proteins; D010281:Parathyroid Hormone; D044169:Receptors, Calcium-Sensing; D050053:TRPM Cation Channels; D014157:Transcription Factors; D000096927:AIRE Protein; C494749:GATA3 protein, human; C119532:GCM2 protein, human; C459082:TRPM6 protein, human; C502010:claudin 16; C406732:GNAS protein, human