Mitochondrial dysfunction and Huntington disease.
Huntington disease (HD) is a chronic autosomal-dominant neurodegenerative disease. The gene coding Huntingtin has been identified, but the pathogenic mechanisms of the disease are still not fully understood. This paper reviews the involvement of mitochondrial dysfunction in pathogenesis of HD.
SooChow University School of Life Sciences; Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China; E-mail: zhqin5@hotmail.com.
Wei-Yan
WY
Zhang
Zhen-Lun
ZL
Gu
Zhong-Qin
ZQ
Liang
Zheng-Hong
ZH
Qin