Aflatoxin induced hemolysis and its amelioration by turmeric extracts and curcumin in vitro.
The present investigation is an attempt to evaluate the possible ameliorative effect of turmeric extracts/curcumin on aflatoxin induced hemolysis in vitro. Blood samples were collected from healthy adult human beings (25-30 years old) in EDTA vials and were used for preparation of RBC suspension in saline. Saline suspension of RBC was treated with aflatoxin (0.5-2.0 microg/mL) with and without turmeric extracts/curcumin (1-100 microg/mL). The results revealed that addition of aflatoxin (0.5-2.0 microg/mL) to RBC suspension caused significant dose-dependent increase in the rate of hemolysis. However, concurrent addition of aflatoxin (2.0 microg/mL) and extracts of turmeric and curcumin caused concentration-dependent retardation in aflatoxin-induced hemolysis.
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad-380 009, India.
Neeta
N
Mathuria
Ramtej Jayram
RJ
Verma
D000348:Aflatoxins / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D030024:Curcuma / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D014867:Water / Q000737:chemistry
D000348:Aflatoxins; D000975:Antioxidants; D010936:Plant Extracts; D014867:Water; D000431:Ethanol; C012596:turmeric extract; D003474:Curcumin