Antidiarrheal activity of dehydroleucodine isolated from Artemisia douglasiana.
Dehydroleucodine (DhL), a sesquiterpene lactone obtained from Artemisia douglasiana, was screened for antidiarrheal effects. DhL inhibited castor oil-induced diarrhea in mice by judged by a decrease in the number of wet faeces in the DhL-treatment groups. DhL significantly reduced intestinal transit in mice. Yohimbine and phentolamine counteracted the inhibitory effect of DhL. It is suggested that alpha2-adrenergic receptors mediate the effect of DhL in intestinal motility. DhL reduced also intraluminal accumulation of fluid. Thus, the antidiarrheal activity of DhL is possibly related, at least in part, to its inhibitory action against gastrointestinal motility and the inhibition of enteropooling property.
Cátedra de Farmacología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera (5700), San Luis, Argentina. gwendel@unsl.edu.ar
G H
GH
Wendel
A O M
AO
María
J A
JA
Guzmán
O
O
Giordano
L E
LE
Pelzer
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D019306:Artemisia; D002368:Castor Oil; D003672:Defecation / Q000187:drug effects; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy*; D005765:Gastrointestinal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D007783:Lactones / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D010646:Phentolamine / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D015016:Yohimbine / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D005765:Gastrointestinal Agents; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; D015016:Yohimbine; C079949:dehydroleucodine; D002368:Castor Oil; D010646:Phentolamine