Meal fatty acid uptake in visceral fat in women.
OBJECTIVE
Differential meal fat uptake into adipose tissue depots may be a determinant of body fat distribution.


METHODS
We used the meal fat tracer/adipose tissue biopsy approach to compare the effects of meal fat content on the fat uptake into visceral and upper and lower body subcutaneous fat depots in 21 premenopausal women. [(3)H]triolein was used to trace the fate of fatty acids from a normal-fat or high-fat meal.


RESULTS
The proportion of dietary fat uptake into the three depots did not differ between meals; visceral fat accounted for only approximately 5% of meal fat disposal irrespective of visceral fat mass. For the women consuming the normal-fat meal, the uptake of meal fatty acid into femoral fat (milligrams meal fat per gram lipid) increased as a function of leg fat mass (r = 0.68, P < 0.05), which we interpret as increased efficiency of uptake. The opposite pattern was seen in omental fat with the normal-fat meal and in all depots after the high-fat meal. For both meals, approximately 40% of meal fat was oxidized ((3)H(2)O production) after 24 h.


CONCLUSIONS
We conclude that greater thigh adipose tissue in women is associated with greater efficiency of meal fat storage under conditions of energy balance, whereas the opposite is seen with visceral fat. These findings imply that different mechanisms may regulate fatty acid uptake in different depots, which may in turn impact on body fat distribution.
Votruba
Susanne B
SB
Mayo Clinic, Endocrine Research Unit, 200 1st St. SW, Rm. 5-194 Joseph, Rochester, MN 55905, USA.
Mattison
Rebecca S
RS
Dumesic
Daniel A
DA
Koutsari
Christina
C
Jensen
Michael D
MD
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000502:physiology*; D001692:Biological Transport; D001835:Body Weight; D004041:Dietary Fats; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000378:metabolism; D017697:Premenopause; D011865:Radioisotope Dilution Technique; D013246:Sterilization, Tubal; D014304:Triolein / Q000378:metabolism*; D014316:Tritium
D004041:Dietary Fats; D005227:Fatty Acids; D014316:Tritium; D014304:Triolein