Fatal anaphylactoid reaction after primary exposure to aprotinin.
Aprotinin is widely used to prevent bleeding, inhibit systemic inflammatory response and reduce blood transfusions after cardiac surgery. Because it is a bovine protein, aprotinin can induce hypersensitivity reactions. We report a case of fatal anaphylactoid reaction to primary aprotinin exposure in a woman who was admitted for mitral valve replacement. The possibility of anaphylactic reaction should be considered whenever aprotinin is used.
Department of Cardiac Surgery, Virgen de la Salud Hospital, Avda. Barber, 30, 45004 Toledo, Spain. lopezalmodovar@yahoo.es
Luis Fernando López
LF
Almodóvar
Pedro
P
Lima
Alfonso
A
Cañas
Manuel
M
Calleja