[Changes in functional activity of macrophages caused by bacterial muramylpeptides].
Muramylpeptides from bacteria cell wall are strong stimulators of immune system and phagocytic cells are main effectors. Dimer containing glucoseaminylmuramylpentapeptide (di-GMPP) was obtained from cell wall of Salmonella typhi bacteria. Di-GMPP decrease the phagocytic activity of macrophages obtained from peripheral blood of healthy donors and increase intracellular killing. Also di-GMPP resulted in decrease of expression of macrophages' receptors which play role in phagocytosis (CD16, CD64, CD11b) and detection of bacterial molecular patterns (TLR2, TLR4, CD206), as well as in increase of expression of antigen-presenting (HLA-DR) and costimulatory molecules (CD86, CD40) which involved in formation of immunological synapse and presentation of antigens to T- and B-lymphocytes.
Karsonova
M I
MI
Il'inskaia
A N
AN
L'vov
V L
VL
Pinegin
B V
BV
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000302:isolation & purification / Q000494:pharmacology*; D000328:Adult; D017951:Antigen Presentation; D001402:B-Lymphocytes / Q000276:immunology; D051940:B7-2 Antigen / Q000378:metabolism; D001424:Bacterial Infections / Q000276:immunology; D001426:Bacterial Proteins / Q000032:analysis / Q000378:metabolism; D039481:CD11b Antigen / Q000032:analysis / Q000378:metabolism; D019013:CD40 Antigens / Q000378:metabolism; D002473:Cell Wall / Q000737:chemistry; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism; D007963:Leukocytes, Mononuclear; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism; D008875:Middle Aged; D010587:Phagocytosis / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000032:analysis / Q000378:metabolism; D017452:Receptors, IgG / Q000032:analysis / Q000378:metabolism; D012485:Salmonella typhi / Q000737:chemistry; D013211:Staphylococcus aureus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D051940:B7-2 Antigen; D001426:Bacterial Proteins; D039481:CD11b Antigen; D019013:CD40 Antigens; D006684:HLA-DR Antigens; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D017452:Receptors, IgG; D000119:Acetylmuramyl-Alanyl-Isoglutamine