[Viral infection of herpes simplex, Epstein-Barr, varicela zoster, human papilloma, cytomegalovirus, or adenovirus are not related to sinonasal adenocarcinomas].
OBJECTIVE
Several types of virus have been implicated in the development of head and neck tumors. However, until now sinonasal adenocarcinomas (ACN) have not been studied. The aim of this study is to screen a series of ACN for the presence of a number of viruses known to play a role in cancer.


METHODS
Viral DNA sequences of herpes simplex virus, Epstein-Barr, varicela zoster, human papilloma, cytomegalovirus, and adenovirus were analysed by PCR in 37 primary ACN.


RESULTS
Three tumors (8.1%) were positive for Epstein-Barr virus and 1 case (2.7%) for cytomegalovirus.


CONCLUSIONS
Viral infections do not seem to play a role in the etiology of ACN.
Pérez Escuredo
Jhudit
J
Departamento de Otorrinolaringología, IUOPA, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
Llorente
José Luis
JL
Melón
Santiago
S
de Oña
María
M
García Martínez
Jorge
J
Alvarez Marcos
César
C
Hermsen
Mario
M
D000230:Adenocarcinoma / Q000473:pathology / Q000821:virology*; D000257:Adenoviridae Infections / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000235:genetics*; D005260:Female; D006561:Herpes Simplex / Q000235:genetics*; D006562:Herpes Zoster / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000235:genetics*; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D015995:Prevalence
D004279:DNA, Viral