TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning.
Ciguatera fish poisoning and neurotoxic shellfish poisoning are distinct clinical entities characterized by gastrointestinal and neurological disturbances, following the consumption of certain reef fish and shellfish containing toxic polyether compounds sporadically present in certain toxic marine dinoflagellates. The biotransformation and bioaccumulation of gambierol and brevetoxin, and their congeners, are believed to be involved in the pathogenesis of these "food-chain diseases", for which no effective treatments are available. Here, we describe for the first time the potent effect of gambierol and brevetoxin on TRPV1 channels, a key player in thermal and pain sensation. Our findings may lead to promising new therapeutic interventions.
Laboratorium voor Toxicologie, Campus Gasthuisberg, Herestraat 49, bus 922, KULeuven, B-3000, Belgium.
Eva
E
Cuypers
Angel
A
Yanagihara
Jon D
JD
Rainier
Jan
J
Tytgat
D000818:Animals; D036841:Ciguatera Poisoning / Q000209:etiology; D002922:Ciguatoxins / Q000737:chemistry / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008387:Marine Toxins / Q000737:chemistry / Q000494:pharmacology* / Q000506:poisoning; D035964:Oxocins / Q000737:chemistry / Q000494:pharmacology* / Q000506:poisoning; D018408:Patch-Clamp Techniques; D011083:Polycyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D012758:Shellfish; D050916:TRPV Cation Channels / Q000378:metabolism*; D014982:Xenopus laevis; D000095702:Polyether Toxins
D002922:Ciguatoxins; D004988:Ethers, Cyclic; D008387:Marine Toxins; D035964:Oxocins; D011083:Polycyclic Compounds; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; C435770:gambierol; C053342:brevetoxin; D000095702:Polyether Toxins