Antiinflammatory and analgesic activities of Thesium chinense Turcz extracts and its major flavonoids, kaempferol and kaempferol-3-O-glucoside.
The ethyl acetate, chloroform extracts, and the two flavonoids kaempferol 1 and kaempferol-3-O-glucoside 2 isolated from whole plants of Thesium chinense Turcz were investigated for their antiinflammatory and analgesic activities. For the antiinflammatory activity, carrageenan-induced hind paw edema and xylene-induced mouse ear edema models, and for the analgesic activity, the acetic acid-induced abdominal constriction test was used. The ethyl acetate extract and two flavonoids showed significant (p<0.05 and p<0.01) and dose-dependent antiinflammatory and analgesic activity. The chloroform extract was inactive in the assay.
Parveen
Zahida
Z
School of Life Sciences and Technology, Beijing Institute of Technology, P.R. China. zahidaparveen_18@yahoo.com
Deng
Yulin
Y
Saeed
Muhammad Khalid
MK
Dai
Rongji
R
Ahamad
Waqar
W
Yu
Yu Hong
YH
D000818:Animals; D002351:Carrageenan; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000627:therapeutic use*; D044949:Kaempferols / Q000302:isolation & purification / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D029630:Santalaceae / Q000737:chemistry*
D005419:Flavonoids; D044949:Kaempferols; D010936:Plant Extracts; C006552:kaempferol; D002351:Carrageenan