Cardiovascular responses to cognitive stress in patients with migraine and tension-type headache.
BACKGROUND
The purpose of this study was to investigate the temporal relationship between autonomic changes and pain activation in migraine and tension-type headache induced by stress in a model relevant for everyday office-work.


METHODS
We measured pain, blood pressure (BP), heart rate (HR) and skin blood flow (BF) during and after controlled low-grade cognitive stress in 22 migraineurs during headache-free periods, 18 patients with tension-type headache (TTH) and 44 healthy controls. The stress lasted for one hour and was followed by 30 minutes of relaxation.


RESULTS
Cardiovascular responses to cognitive stress in migraine did not differ from those in control subjects. In TTH patients HR was maintained during stress, whereas it decreased for migraineurs and controls. A trend towards a delayed systolic BP response during stress was also observed in TTH. Finger BF recovery was delayed after stress and stress-induced pain was associated with less vasoconstriction in TTH during recovery.


CONCLUSIONS
It is hypothesized that TTH patients have different stress adaptive mechanisms than controls and migraineurs, involving delayed cardiovascular adaptation and reduced pain control system inhibition.
Department of Neurosciences, Norwegian University of Science and Technology, Trondheim, Norway. rune.leistad@ntnu.no
Rune B
RB
Leistad
Trond
T
Sand
Kristian B
KB
Nilsen
Rolf H
RH
Westgaard
Lars Jacob
LJ
Stovner
D000222:Adaptation, Physiological; D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D001919:Bradycardia / Q000209:etiology / Q000503:physiopathology; D002319:Cardiovascular System / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D010147:Pain Measurement; D011930:Reaction Time; D012039:Regional Blood Flow / Q000502:physiology; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*; D018781:Tension-Type Headache / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D013997:Time Factors