[Genetic background of sarcoidosis].
Sarcoidosis is a multisystemic disease of unknown pathogenesis. Its characteristic feature is formation of noncaseating granuloma in involved organs. The current etiologic hypothesis suggests that an unknown antigen/ agent might promote granuloma formation in hosts genetically susceptible to Th1 - response. The network of interactions between immunocompetent cells (mainly Th1-lymphocytes and macrophages) and the influence of many cytokines and chemokines lead to the sarcoid granuloma formation. The variations in prevalence and incidence of this disease in individuals from different ethnic, racial groups or families show, that the genetic factors are also involved in sarcoidosis etiology. Although there is a clear genetic influence on the risk of sarcoidosis, the relation between clinical course of the disease is an area for further exploration in the future.
Agata
A
Krawczyk
D018925:Chemokines; D020022:Genetic Predisposition to Disease; D006099:Granuloma / Q000235:genetics* / Q000276:immunology; D006801:Humans; D015994:Incidence; D015995:Prevalence; D012507:Sarcoidosis / Q000235:genetics* / Q000276:immunology; D018417:Th1 Cells
D018925:Chemokines