Studies of the skin permeation of lipophilic drugs: paclitaxel.
The objective of this investigation was to develop and validate skin permeation methodology for a highly lipophilic drug with respect to sink conditions and intactness of barrier during the course of experiment, using water permeation and trans epidermal water loss as tools.
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India.
S
S
Khandavilli
R
R
Panchagnula
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D015194:Diffusion Chambers, Culture; D000431:Ethanol; D066298:In Vitro Techniques; D008055:Lipids / Q000737:chemistry; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D010539:Permeability; D014677:Pharmaceutical Vehicles; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption; D014870:Water Loss, Insensible
D000972:Antineoplastic Agents, Phytogenic; D008055:Lipids; D014677:Pharmaceutical Vehicles; D000431:Ethanol; D017239:Paclitaxel