Diphoterine chemical splash decontamination solution: skin sensitization study in the guinea pig.
Diphoterine is an active eye/skin chemical splash decontamination solution. It was evaluated for sensitization potential in the guinea pig with primary induction (day 1, intradermal injection), sensitization (day 9, topical application), and challenge (day 22, topical application). Allergenicity degree at 24 and 48 hours was based on the percentage of animals showing a reaction. Under these conditions, no irritation was noted at 24 and 48 hours in negative controls and in animals treated with Diphoterine during the challenge phase. Diphoterine showed no allergenicity at 24 and 48 hours. In this study, Diphoterine lacked sensitizing capacity in the guinea pig.
Laboratoire Prevor, Moulin de Verville, Valmondois, France.
Laurence
L
Mathieu
François
F
Burgher
Alan H
AH
Hall
D000279:Administration, Cutaneous; D000818:Animals; D002057:Burns, Chemical / Q000628:therapy*; D003666:Decontamination / Q000379:methods*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced*; D005126:Eye Burns / Q000628:therapy*; D005260:Female; D006168:Guinea Pigs; D007271:Injections, Intradermal; D008297:Male; D009883:Ophthalmic Solutions / Q000633:toxicity; D009930:Organic Chemicals / Q000008:administration & dosage / Q000633:toxicity; D019999:Pharmaceutical Solutions / Q000008:administration & dosage / Q000633:toxicity*; D012720:Severity of Illness Index; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests; D007507:Therapeutic Irrigation; D013997:Time Factors
D009883:Ophthalmic Solutions; D009930:Organic Chemicals; D019999:Pharmaceutical Solutions; C472007:diphoterine