An update on the amyloid hypothesis.
Alzheimer's disease (AD) is a devastating neurodegenerative disease. To rationally develop novel therapeutic and/or preventative agents for AD, an understanding of the etiology and pathogenesis of this complex disease is necessary. This article examines the evidence for the amyloid hypothesis of AD pathogenesis and discusses how it relates to the neurological and neuropathological features of AD, the known genetic risk factors and causative mutations, and the heightened risk associated with advanced age.
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA. eckman@mayo.edu
Christopher B
CB
Eckman
Elizabeth A
EA
Eckman
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000235:genetics*; D000686:Amyloidosis / Q000235:genetics* / Q000473:pathology*; D000818:Animals; D006801:Humans
D016229:Amyloid beta-Peptides