Association between RANTES polymorphisms and asthma severity among Tunisian children.
The chemokine known as RANTES (regulated upon activation, normal T cells expressed and secreted) is an important element for the chemotaxis at the site of allergic inflammation. Many studies have made an interesting link between RANTES polymorphisms and asthma, showing that the variant in the promoter region is associated with high risk of asthma and severe airway obstruction. We conducted a case-control and family study aiming at identifying the relationship between polymorphisms (-28 C/G and -403 G/A) and haplotypes in the RANTES gene with asthma and severity. The results of the case control study suggest an association between alleles level of -28 C/G and -403 G/A promoter polymorphism (p = 0.01) (p = 0.00175) and asthma. Univariate analysis of the RANTES polymorphisms show an increased prevalence of the AC and AG haplotypes in asthmatics (p = 0.014) and (p = 0.015) respectively. Our data suggest that -28 C/G and -403 G/A polymorphisms within the RANTES promoter region play an important role in asthma predisposition and in the severity of airway obstruction.
Lachheb
Jihene
J
Medicine University of Tunis, Homeostasis and cell Dysfunction Unit Research 99/UR/08-40, Tunis, Tunisia. lachheb.jihene@yahoo.fr
Chelbi
Hanene
H
Hamzaoui
Kamel
K
Hamzaoui
Agnès
A
D000293:Adolescent; D001249:Asthma / Q000235:genetics* / Q000276:immunology*; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D014416:Tunisia
D018946:Chemokine CCL5; D007073:Immunoglobulin E