Histological comparison of implanted cadaveric and porcine dermal matrix grafts.
OBJECTIVE
Histological comparison of human-based (AlloDerm) and porcine-based (ENDURAGen) dermal matrices regarding tissue incorporation and neovascularization as potential soft tissue augmentation materials.


METHODS
In vivo, rat model.


METHODS
Subcutaneous implantation of 1-mm thick, 1 cm x 1 cm pieces of AlloDerm, ENDURAGen, and meshed ENDURAGen was performed in 24 Sprague Dawley rats. Implant materials were harvested at 4 (n = 12) and 8 weeks (n = 12). Histological quantification of soft tissue ingrowth and microvascular density was performed following hematoxylin-eosin staining and CD34 immunohistochemistry, respectively.


RESULTS
AlloDerm showed significantly greater soft tissue ingrowth and microvascular density compared with both ENDURAGen and meshed ENDURAGen at 4 and 8 weeks (P < 0.001).


CONCLUSIONS
Although these results may differ in human host tissues, AlloDerm seems to be a more suitable dermal matrix implant than ENDURAGen for cases in which tissue incorporation and neovascularization are sought for the optimal outcome based on this animal model.
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Gresham T
GT
Richter
Jacob E
JE
Smith
Horace J
HJ
Spencer
Chun Y
CY
Fan
Emre
E
Vural
D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D003094:Collagen; D006085:Graft Survival; D006801:Humans; D008297:Male; D018919:Neovascularization, Physiologic; D010784:Photomicrography; D051381:Rats; D017207:Rats, Sprague-Dawley; D019651:Plastic Surgery Procedures / Q000379:methods*; D016038:Skin Transplantation / Q000379:methods / Q000473:pathology; D017768:Skin, Artificial; D018709:Statistics, Nonparametric; D013552:Swine
C440568:Alloderm; D001672:Biocompatible Materials; D003094:Collagen