Idiopathic purpura fulminans in dengue hemorrhagic fever.
Purpura fulminans is a rapidly progressive thrombotic disease that has been described during both severe bacterial and viral infections. Disseminated intravascular coagulation (DIC), antiphospholipid antibodies and acquired or congenital C and S protein deficiency are thought to play a role in its pathogenesis. Here we report the case of a 4-year-old girl who developed gangrene of all her fingers and toes following dengue shock syndrome complicated by DIC and also discuss its management.
Karunatilaka
D H
DH
Lady Ridgeway Hospital for Children, Colombo 8, Sri Lanka. dhkaru@sltnet.lk
De Silva
J R S
JR
Ranatunga
P K
PK
Gunasekara
T Mr
TM
Faizal
M Am
MA
Malavige
G N
GN
D002675:Child, Preschool; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005734:Gangrene / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D019595:Severe Dengue / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology