[Risk of lithiasis and urolithiasis in children with unspecific inflammatory bowel disease].
Urolithiasis is a disease of a complex, often systemic and not fully unequivocal, etiopathological mechanism, resulting in concrement crystallization The aim of study was the evaluation of frequency of occurrences of crystallization risk states and urolithiasis in children with IBD.


METHODS
The study was conducted on 35 children aged between 12 and 18 with confirmed ulcerative colitis (25 children) and Crohn disease (10 children). In all children regiular urine examination and urine inoculation were conducted, as well as stimation of concrement crystallization risk index in a twenty-four hour urine collection. Urinary tract ultrasound as well as evaluation of erythrocytes in urine sediment in phase contrast microscope,have been performed. Control group consisted of 20 children without digestive tract complains.


RESULTS
In 13 (37%) of examined children, urolithiasis occured in family history. The general urine examination revealed in 27 (77%) examined children existence of erytrocyturia of various degree and the evaluation in phase contrast microscope indicated their extraglomucal origin. The ion-creatininal analysis of twenty-four hour urine collection revealed in 29 (82.2%) children risk of oxalate-calcium concrements crystallization and in 6 (17%) children--of oxalate concrements crystallization. USG examination revealed in 4 (11.4%) children existence of single or multiple concrements in urinary system. Analysis of 1 twenty-four hour urine collection indicated the decrease of magnesium ions in 27 (77%) examined children. In control group only in 2 (5.7%) children the risk of occurrence of phosphate-ammonium concrements crystallization, which was significantly lower in examined group (p < 0.01).


CONCLUSIONS
Unspecific intestine inflammations have an influence on the occurrence of crystallization risk states, as well as a fully symptomatic urolithiasis.
Makosiej
Ryszard
R
Instytut Centrum Zdrowia Matki Polki, Łódź, Klinika Gastroenterologii. kpg@iczmp.edu.pl
Czkwianianc
Elzbieta
E
Niedworok
Małgorzata
M
Małecka-Panas
Ewa
E
D000293:Adolescent; D002129:Calcium Oxalate / Q000652:urine; D003093:Colitis, Ulcerative / Q000150:complications; D003424:Crohn Disease / Q000150:complications; D003460:Crystallization; D005260:Female; D006417:Hematuria / Q000209:etiology / Q000652:urine; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D020347:Lithiasis / Q000175:diagnosis / Q000209:etiology* / Q000652:urine; D008274:Magnesium / Q000652:urine; D008297:Male; D010070:Oxalates / Q000652:urine; D019815:Oxalic Acid / Q000652:urine; D012307:Risk Factors; D014545:Urinary Calculi / Q000737:chemistry / Q000652:urine; D014556:Urine / Q000737:chemistry; D052878:Urolithiasis / Q000175:diagnosis / Q000209:etiology* / Q000652:urine
D010070:Oxalates; D002129:Calcium Oxalate; D019815:Oxalic Acid; D008274:Magnesium