[Relationship between tumor necrosis factor A-308 gene polymorphism and aggressive periodontitis].
OBJECTIVE
To investigate the relationship between tumor necrosis factor (TNF) A-308 gene polymorphism and aggressive periodontitis (AgP).


METHODS
Anti-coagulated peripheral blood samples were obtained from 64 AgP patients, and 78 healthy controls (H). Genomic DNA was extracted from each sample. The TNF A-308 gene polymorphism was detected by standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Data were analyzed by SAS statistical software.


RESULTS
There was no significant difference in distribution of TNF A-308 genotype between AgP patients and healthy controls. But the ORs for genotype GA and allele A were 22.2 and 16.1 respectively in non-smoking male AgP patients.


CONCLUSIONS
The TNF A-308 genotype GA and allele A may be associated with AgP susceptibility in Chinese males.
Zhu
Xiao-Ling
XL
Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China.
Meng
Huan-Xin
HX
Xu
Li
L
Zhang
Li
L
Chen
Zhi-Bin
ZB
Shi
Dong
D
D010520:Aggressive Periodontitis / Q000235:genetics*; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha