Determination of optimal dose of arginine vasopressin in hemorrhagic shock in dogs.
The hemodynamic effects of vasopressin of high/low doses on dogs were investigated using experimentally induced hemorrhagic shock model. Experimental groups were categorized according to administered doses of vasopressin (0.1, 0.4 and 1.6 IU/kg) and hemodynamic parameters were measured before and after the graded-dose administration of vasopressin. Administration of high- and middle-dose vasopressin (0.4 and 1.6 IU/kg) showed superior increase in blood pressure and systemic vascular resistance, compared with those of low-dose one (0.1 IU/kg). Results of systolic arterial pressure and mean arterial pressure in 1.6 IU/kg-administered group revealed lower efficacy than that in 0.4 IU/kg group in spite of administration of higher dose. This study demonstrates that 0.4 IU/kg of vasopressin can be used as the most effective dose for improving hemodynamic condition in the decompensatory phase of hemorrhagic shock in dogs.
BK21 Program of Integrative Network Systems for Veterinarians in Basic Science, Industrial Animals and Preventive Medicines, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul, South Korea.
Jong-Hyun
JH
Yoo
Chul
C
Park
Dae-Hyun
DH
Hahm
Hye-Jung
HJ
Lee
Hee-Myung
HM
Park
D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004283:Dog Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous / Q000662:veterinary; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000503:physiopathology / Q000662:veterinary*; D014655:Vascular Resistance / Q000187:drug effects
D001127:Arginine Vasopressin