Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part I.
Aqueous and organic extracts of 25 selected species from four tribes of Hungarian Asteraceae were screened in vitro for antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells, using the MTT assay. Twenty five of the 228 tested extracts from different parts of the species of Astereae (6), Inuleae (3), Heliantheae (5) and Anthemideae (11) demonstrated a substantial antiproliferative effect (at least 50% inhibition of cell proliferation) at 10 microg/mL against one or more of the cell lines. Complete dose-response curves were generated and IC(50) values were calculated for these active extracts, and their direct cytotoxic effects were determined. In summary, 11 of the tested 25 plants were found to be active and 4 of them (Anthemis ruthenica, Erigeron canadensis, Erigeron annuus and Inula ensifolia) had not been studied previously for either active compounds or anticancer properties.
Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Borbála
B
Réthy
Boglárka
B
Csupor-Löffler
István
I
Zupkó
Zsuzsanna
Z
Hajdú
Imre
I
Máthé
Judit
J
Hohmann
Tamás
T
Rédei
George
G
Falkay
D000970:Antineoplastic Agents / Q000032:analysis*; D019659:Asteraceae / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D006814:Hungary; D010936:Plant Extracts / Q000494:pharmacology*
D000970:Antineoplastic Agents; D010936:Plant Extracts