[Expression of chemokine receptor CXCR3 mRNA in patients with atopic dermatitis].
OBJECTIVE
To investigate the role of chemokine receptor CXCR3 in patients with atopic dermatitis.


METHODS
The expression of CXCR3 mRNA was measured by fluorescent quantitative polymerase chain reaction, and the relationship between CXCR3 mRNA expression and the disease severity (graded according to SCORAD index system) was assessed by correlation analysis.


RESULTS
CXCR3 mRNA expression was significantly higher in patients with atopic dermatitis than in healthy control subjects (P7lt;0.01), and showed obvious positive correlation with SCORAD index system.


CONCLUSIONS
These data suggest an important role of CXCR3 in the development and progression of atopic dermatitis.
Lai
Gui-mei
GM
People's Hospital of Dongguan, Dongguan 523000, China.
Lin
Shao-hua
SH
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D003876:Dermatitis, Atopic / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D054367:Receptors, CXCR3 / Q000235:genetics*
C515187:CXCR3 protein, human; D012333:RNA, Messenger; D054367:Receptors, CXCR3