Influence of three anesthetic protocols on glomerular filtration rate in dogs.
OBJECTIVE
To investigate renal function in clinically normal dogs when awake and during anesthesia with medetomidine; xylazine, ketamine, and halothane (XKH) combination; or propofol.


METHODS
10 adult female Beagles.


METHODS
At intervals of 15 days, dogs were administered medetomidine (0.05 mg/kg, IV); XKH combination (xylazine [1 mg/kg, IV], ketamine [5 mg/kg, IV], and halothane [1% end-tidal concentration]); or propofol (6 mg/kg, IV) to induce anesthesia or no treatment. Glomerular filtration rate was assessed on the basis of renal uptake (RU; determined via renal scintigraphy) and plasma clearance (CL) of technetium 99m-labeled diethylenetriamine pentaacetic acid ((99m)Tc-DTPA).


RESULTS
In awake dogs, mean +/- SEM RU was 9.7 +/- 0.4% and CL was 3.86 +/- 0.23 mL/min/ kg. Renal uptake and CL of (99m)Tc-DTPA were not significantly modified by administration of XKH (RU, 11.4 +/- 0.9%; CL, 4.6 +/- 0.32 mL/min/kg) or propofol (RU, 9.7 +/- 0.3%; CL, 3.78 +/- 0.37 mL/min/kg). Half-life elimination time of plasma (99m)Tc-DTPA decreased significantly in XKH-anesthetized dogs, compared with the value in awake dogs (14.4 minutes and 28.9 minutes, respectively). However, glomerular filtration rate was significantly decreased by administration of medetomidine (RU, 3.9 +/- 0.1%), and the time to maximum kidney activity was significantly increased (867 +/- 56 seconds vs 181 +/- 11 seconds without anesthesia).


CONCLUSIONS
Results indicated that anesthesia with propofol or an XKH combination did not alter renal function in healthy Beagles, but anesthesia with medetomidine decreased early RU of (99m)Tc-DTPA.
Animal Pathophysiology and Functional Pharmacology Unit (UPSP 5304), National Veterinary School, BP 40706, F-44307 Nantes, France.
Marion
M
Fusellier
Jean-Claude
JC
Desfontis
Stéphane
S
Madec
Freddy
F
Gautier
Michelle
M
Debailleul
Marc
M
Gogny
D000758:Anesthesia / Q000662:veterinary*; D000777:Anesthetics / Q000009:adverse effects* / Q000494:pharmacology*; D000818:Animals; D018592:Cross-Over Studies; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000662:veterinary*
D000777:Anesthetics