Development of mast cells: analysis with mutant mice.
Mast cells are the progeny of hematopoietic stem cells. Mutant mice lacking mast cells or possessing abnormal mast cells, such as W/Wv, Sl/Sld, and mi/mi, are useful for investigating the developmental process. Recently, mast cell progenitors were identified with sorting techniques. Recent progress in research into mast cell development is reviewed.
Department of Pathology, Osaka University School of Medicine, Osaka, Japan. morii@patho.med.osaka-u.ac.jp
Eiichi
E
Morii
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics* / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains / Q000502:physiology*; D010641:Phenotype; D019089:Stem Cell Factor / Q000378:metabolism
D015703:Antigens, CD; D019089:Stem Cell Factor