Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release.
Adiponectin circulates as trimer (LMW), hexamer (MMW) and high molecular weight multimer (HMW) but the distribution and effects of these isoforms have not been studied in detail. Monocytes were isolated from normal weight and overweight controls and patients with type 2 diabetes mellitus (T2D) and monocytic release of IL-6 positively correlated with the body mass index (BMI). HMW-adiponectin further enhanced and LMW-adiponectin reduced IL-6 release in monocytes. Systemic total adiponectin, and the HMW isoform were not different in these groups but MMW-adiponectin was lower in T2D, and LMW-adiponectin was reduced in the obese and T2D. Circulating LMW-adiponectin negatively correlated to monocytic IL-6 release. Systemic IL-6 was higher in the obese control group and T2D, respectively, but did not correlate with monocytic IL-6 secretion. Therefore, the current study indicates that HMW-adiponectin exerts pro- and LMW-adiponectin antiinflammatory effects and reduced LMW-adiponectin in obesity may partly contribute to elevated monocytic IL-6 release.
Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany.
Franziska
F
Schober
Markus
M
Neumeier
Johanna
J
Weigert
Sylvia
S
Wurm
Josef
J
Wanninger
Andreas
A
Schäffler
Ashraf
A
Dada
Gerhard
G
Liebisch
Gerd
G
Schmitz
Charalampos
C
Aslanidis
Christa
C
Buechler
D052242:Adiponectin / Q000097:blood / Q000737:chemistry / Q000494:pharmacology; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001837:Body Weights and Measures; D002478:Cells, Cultured; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D009765:Obesity / Q000276:immunology*; D020033:Protein Isoforms / Q000097:blood
C499918:ADIPOQ protein, human; D052242:Adiponectin; D015850:Interleukin-6; D020033:Protein Isoforms