[Correlation between HLA antigens with clinical features of mixed infection of hepatitis A and HBV-carriers].
It is showed that HAV+HBV mixed infection is a genetically determined pathology. Following HLA-antigens were immunogenetic markers of the disease: HLA-A10, B21, Cw2, Cw5, A10-A19, 88-813, B21-B35, A3-821, A9-B21. Lower risk of disease development was associated with HLA-B5, A2-Cw3, A3-Cw4, B35-Cw4, A3-B35-Cw4. Atypical forms of the hepatitis A were often met in carriers of HLA-Cw5, 827-835, A3-814, A3-B21, A9-B21, whereas typical forms - in carriers of HLA-A10, Cw2, A10-A19, B8-813, 821-835. Mild forms of hepatitis A were associated with the presence of HLA-A10,B22, A10-A19, B8-B13, A3-B21, A9-B8, A10-814, A10-822, A10-Cw3 in the patients' phenotype, whereas intermediate and severe forms - with the presence of HLA-B17, 817-818, 821 - 835, A28-B21, B18-Cw2. The findings about distribution of HLA-antigens and their combinations in mixed hepatitis A+B can be used in attempt of their prediction and prevention.
Bondarenko
A L
AL
Ustiuzhaninov
V N
VN
Vozhegova
N P
NP
Strazhnikova
G A
GA
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D002353:Carrier State / Q000175:diagnosis / Q000276:immunology; D018450:Disease Progression; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006506:Hepatitis A / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D006509:Hepatitis B / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D006680:HLA Antigens