A high-sodium diet in streptozotocin-induced diabetic rats impairs endothelium-derived hyperpolarizing factor-mediated vasodilation.
We examined endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of mesenteric arteries in high-sodium loaded streptozotocin (STZ)-induced diabetic rats. The study shows that acetylcholine (ACh)-induced, EDHF-mediated relaxation is relatively maintained in STZ-induced diabetic rats, but after a high-sodium diet was given, the function was significantly impaired in STZ-induced diabetic rats.
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Yasutoshi
Y
Hirabara
Mina
M
Araki
Mio
M
Fukuda
Shiori
S
Katafuchi
Kenji
K
Honda
Ryo
R
Saito
Yukio
Y
Takano
D000109:Acetylcholine; D000818:Animals; D001685:Biological Factors / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008638:Mesenteric Arteries / Q000503:physiopathology; D010656:Phenylephrine; D051381:Rats; D017208:Rats, Wistar; D012982:Sodium, Dietary / Q000008:administration & dosage / Q000009:adverse effects*; D013311:Streptozocin; D014664:Vasodilation / Q000187:drug effects*
D001685:Biological Factors; D012982:Sodium, Dietary; C067410:endothelium-dependent hyperpolarization factor; D010656:Phenylephrine; D013311:Streptozocin; D000109:Acetylcholine