QT Interval prolongation and torsades de pointes due to a coadministration of ciprofloxacin and azimilide in a patient with implantable cardioverter-defibrillator.
The presented case report describes a male patient with an implanted cardioverter-defibrillator (ICD) in whom a coadministration of ciprofloxacin and azimilide caused QT interval prolongation and multiple episodes of torsades de pointes (TdP) followed by ICD shocks (arrhythmic storm). The case highlights a not described drug interaction between azimilide and ciprofloxacin, which is believed to be the safest member of fluoroquinolones class.
Department of Cardiology, Medical University, ul. Powstańców Wlkp. 72, 71-999 Szczecin, Poland. j.kazmierczak@acx.pl
Jarosław
J
Kaźmierczak
Małgorzata
M
Peregud-Pogorzelska
Ryszard
R
Rzeuski
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D017147:Defibrillators, Implantable; D004347:Drug Interactions; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006827:Hydantoins; D048289:Imidazolidines / Q000008:administration & dosage / Q000009:adverse effects*; D008133:Long QT Syndrome / Q000139:chemically induced*; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects*; D017180:Tachycardia, Ventricular / Q000503:physiopathology / Q000628:therapy; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D000890:Anti-Infective Agents; D006827:Hydantoins; D048289:Imidazolidines; D010879:Piperazines; D002939:Ciprofloxacin; C086123:azimilide