Practical approaches of taste masking technologies in oral solid forms.
In the pharmaceutical industry, taste masking techniques are applied to prevent active pharmaceutical ingredients exhibiting a bitter and unpleasant taste. The oral administration of bitter drugs through solid dosage forms requires an acceptable degree of palatability, patient tolerance and significant therapeutic value. In the recent years, enormous progress in taste masking technologies has given rise to novel strategies such as fast dissolving dosage forms, chewable tablets and coating of molten materials. Similarly, common technologies applying double coating layers, microencapsulation or even chemical modification have been employed to improve patient compliance. This review endeavours to present the practical technologies and platforms applied for taste masking and indicate the most interesting features of each approach.
Douroumis
Dionysios
D
Phoqus Pharmaceutical Limited, 10 Kings Hill Avenue, Kings Hill, West Malling, ME19 4PQ, Kent, UK. dionysios.douroumis@phoqus.com
D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D006801:Humans; D007700:Kinetics; D008409:Mastication; D010349:Patient Compliance; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013649:Taste; D013678:Technology, Pharmaceutical / Q000379:methods
D004364:Pharmaceutical Preparations; D013607:Tablets