Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.
Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function. Over the last decade, considerable progress has been made in delineating the VEGFR-2 specific intracellular signalling cascades leading to proliferation, migration, survival and increased permeability, each of which contributes to the angiogenic response. Furthermore, therapeutic inhibition of VEGFR-2 action is now having an impact in the clinic for the treatment of a number of diseases.
Holmes
Katherine
K
North West Cancer Research Fund Institute, School of Biological Sciences, College of Natural Sciences, University of Wales, Bangor, UK.
Roberts
Owain Ll
OL
Thomas
Angharad M
AM
Cross
Michael J
MJ
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D015398:Signal Transduction; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000502:physiology*; D042442:Vascular Endothelial Growth Factors / Q000235:genetics / Q000378:metabolism
D042442:Vascular Endothelial Growth Factors; D040301:Vascular Endothelial Growth Factor Receptor-2