High-frequency oscillations (>200 Hz) in the human non-parkinsonian subthalamic nucleus.
The human basal ganglia, and in particular the subthalamic nucleus (STN), can oscillate at surprisingly high frequencies, around 300 Hz [G. Foffani, A. Priori, M. Egidi, P. Rampini, F. Tamma, E. Caputo, K.A. Moxon, S. Cerutti, S. Barbieri, 300-Hz subthalamic oscillations in Parkinson's disease, Brain 126 (2003) 2153-2163]. It has been proposed that these oscillations could contribute to the mechanisms of action of deep brain stimulation (DBS) [G. Foffani, A. Priori, Deep brain stimulation in Parkinson's disease can mimic the 300 Hz subthalamic rhythm, Brain 129 (2006) E59]. However, the physiological role of high-frequency STN oscillations is questionable, because they have been observed only in patients with advanced Parkinson's disease and could therefore be secondary to the dopamine-depleted parkinsonian state. Here, we report high-frequency STN oscillations in the range of the 300-Hz rhythm during intraoperative microrecordings for DBS in an awake patient with focal dystonia as well as in a patient with essential tremor (ET). High-frequency STN oscillations are therefore not exclusively related to parkinsonian pathophysiology, but may represent a broader feature of human STN function.
Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
S F
SF
Danish
J T
JT
Moyer
L H
LH
Finkel
G H
GH
Baltuch
J L
JL
Jaggi
A
A
Priori
G
G
Foffani
D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods*; D004421:Dystonia / Q000503:physiopathology*; D005260:Female; D006612:High-Frequency Ventilation; D006801:Humans; D008875:Middle Aged; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D014202:Tremor / Q000503:physiopathology*