Rationally designing molecularly imprinted polymer towards predetermined high selectivity by using metal as assembled pivot.
This article presents an original work aiming at rationally designing a molecularly imprinted polymer (MIP) towards high selective recognition. Assembled with (S)-naproxen as a template and 4-vinylpyridine as a functional monomer, a certain amount of cobalt, as pivot, is added for the preparation of MIP. The result indicates that the use of pivot plays obviously a positive role in increasing the specificity of MIP, so as to adsorb more for the template and less for its enantiomer. Related information indicates that this, in logic, can be a result of increasing match between binding sites and the templates, which makes the polymer capable of selectively recognizing the imprint species.
Li
Songjun
S
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China. lsjchem@yahoo.com.cn
Liao
Cong
C
Li
Wuke
W
Chen
Yifeng
Y
Hao
Xiao
X
D000327:Adsorption; D003035:Cobalt / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry; D008422:Materials Testing; D008670:Metals / Q000737:chemistry*; D054802:Molecular Imprinting; D015394:Molecular Structure; D009288:Naproxen / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D012680:Sensitivity and Specificity; D013499:Surface Properties; D013696:Temperature
D007202:Indicators and Reagents; D008670:Metals; D011108:Polymers; D011725:Pyridines; D003035:Cobalt; D009288:Naproxen; C029351:4-vinylpyridine