Brief report: normal intestinal permeability at elevated platelet serotonin levels in a subgroup of children with pervasive developmental disorders in Curaçao (The Netherlands antilles).
This study investigated the relationship between platelet (PLT) serotonin (5-HT) and intestinal permeability in children with pervasive developmental disorders (PDD). Differential sugar absorption and PLT 5-HT were determined in 23 children with PDD. PLT 5-HT (2.0-7.1 nmol/10(9) PLT) was elevated in 4/23 patients. None exhibited elevated intestinal permeability (lactulose/mannitol ratio: 0.008-0.035 mol/mol). PLT 5-HT did not correlate with intestinal permeability or GI tract complaints. PLT 5-HT correlated with 24 h urinary 5-hydroxyindoleacetic acid (5-HIAA; p = .034). Also urinary 5-HIAA and urinary 5-HT were interrelated (p = .005). A link between hyperserotonemia and increased intestinal permeability remained unsupported. Increased PLT 5-HT in PDD is likely to derive from increased PLT exposure to 5-HT. Longitudinal studies, showing the (in)consistency of abnormal intestinal permeability and PLT 5-HT, may resolve present discrepancies in the literature.
Department of Pathology and Laboratory Medicine, CMC-V 1st Floor, Room Y3.181, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. r.f.j.kemperman@rug.nl
Ramses F J
RF
Kemperman
Fred D
FD
Muskiet
A Inge
AI
Boutier
Ido P
IP
Kema
Frits A J
FA
Muskiet
D001792:Blood Platelets / Q000378:metabolism*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000503:physiopathology*; D003967:Diarrhea / Q000503:physiopathology; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D007408:Intestinal Absorption / Q000502:physiology*; D043183:Irritable Bowel Syndrome / Q000175:diagnosis / Q000503:physiopathology; D007792:Lactulose / Q000378:metabolism; D008297:Male; D008353:Mannitol / Q000378:metabolism; D012307:Risk Factors; D012701:Serotonin / Q000097:blood*; D013395:Sucrose / Q000378:metabolism; D014687:Venezuela; D014839:Vomiting / Q000175:diagnosis / Q000503:physiopathology
D012701:Serotonin; D008353:Mannitol; D007792:Lactulose; D006897:Hydroxyindoleacetic Acid; D013395:Sucrose