G2/M cell cycle arrest in the life cycle of viruses.
There is increasing evidence that viral infection, expression of viral protein or the presence of viral DNA causes the host cell cycle to arrest during G2/M. The mechanisms used by viruses to cause arrest vary widely; some involve the activation of the cellular pathways that induce arrest in response to DNA damage, while others use completely novel means. The analysis of virus-mediated arrest has not been proven easy, and in most cases the consequences of arrest for the virus life cycle are not well defined. However, a number of effects of arrest are being investigated and it will be interesting to see to what extent perturbation of the G2/M transition is involved in viral infections.
Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.
Clare
C
Davy
John
J
Doorbar
D016195:G2 Phase / Q000502:physiology*; D015658:HIV Infections / Q000503:physiopathology / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D027383:Papillomaviridae / Q000472:pathogenicity / Q000502:physiology; D014777:Virus Diseases / Q000503:physiopathology / Q000821:virology; D014779:Virus Replication; D014780:Viruses / Q000145:classification / Q000254:growth & development / Q000472:pathogenicity*