Clinical, neurovascular and neuropathological features in Sneddon's syndrome.
Sneddon's syndrome (SS) is characterized by ischemic cerebrovascular episodes and livedo reticularis. It is more common in young women and can also be associated with valvulopathy, a history of spontaneous abortion, renal involvement and vascular dementia. We describe three cases of young women with this disease. The patients had repeated ischemic cerebral episodes, livedo reticularis and thrombocytopenia. CT and MRI showed strokes and cerebral atrophy. Autopsy in one of the patients revealed cerebral infarctions. Anticardiolipin antibodies were detected in two patients. Antiphospholipid antibodies may be found in some patients with ischemic cerebrovascular events and livedo reticularis. SS may thus be associated with antiphospholipid syndrome. We described three new cases of SS and discuss the pathophysiology of this disease.
Ribeirão Preto Faculty of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.
Jaqueline Luvisotto
JL
Marinho
Elcio Juliato
EJ
Piovesan
Moacir Pereira
MP
Leite Neto
Luiz Roberto
LR
Kotze
Lúcia de
Ld
Noronha
Carlos Alexandre
CA
Twardowschy
Marcos Christiano
MC
Lange
Rosana Hermínia
RH
Scola
Viviane H Flumignan
VH
Zétola
Edison Matos
EM
Nóvak
Lineu César
LC
Werneck
D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood; D002533:Cerebral Angiography; D004452:Echocardiography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018860:Sneddon Syndrome / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed
D017152:Antibodies, Antiphospholipid