Neurogenesis associated with endothelin-induced cortical infarction in the mouse.
We investigated the effect of small cortical ischemic lesions, produced by intracerebral injection of the vasoconstrictor endothelin-1, on neurogenesis in the adult mouse subventricular zone. Endothelin-1 (0.5-1 microg) produced infarcts restricted to the cortex, and associated neurobehavioral deficits that largely resolved by 3 days. Bromodeoxyuridine labeling of proliferating cells in the subventricular zone was elevated by about 50% in endothelin-1-treated mice, and cells reactive for doublecortin, a marker for immature neurons, were similarly increased in number. These findings indicate that small ischemic lesions restricted to adult cerebral cortex can stimulate neuroproliferation at a distance.
Buck Institute for Age Research, Novato, CA 94945, USA.
Yaoming
Y
Wang
Kunlin
K
Jin
David A
DA
Greenberg
D000818:Animals; D015415:Biomarkers; D002545:Brain Ischemia / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects*; D002544:Cerebral Infarction / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D000089622:Doublecortin Domain Proteins; D019332:Endothelin-1 / Q000633:toxicity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology*; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D009479:Neuropeptides / Q000378:metabolism; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000633:toxicity
D015415:Biomarkers; D000089622:Doublecortin Domain Proteins; D019332:Endothelin-1; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D014662:Vasoconstrictor Agents