Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing.
Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.
Department of Chemistry, University of California Irvine, Irvine, CA 92697, USA.
Alastair W
AW
Wark
Hye Jin
HJ
Lee
Abraham J
AJ
Qavi
Robert M
RM
Corn
D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D004247:DNA / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods*
D006046:Gold; D004247:DNA