Preeclampsia and maternal breast cancer risk by offspring gender: do elevated androgen concentrations play a role?
Among older mothers, preeclampsia in the first pregnancy was associated with a reduction in maternal breast cancer risk that was significantly more pronounced in women bearing male than female infants. Androgen concentrations in male, preeclamptic pregnancies were consistent with the hypothesis that elevated pregnancy androgens might mediate this apparent modifying effect of fetal gender.
Troisi
R
R
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7246, USA. troisir@mail.nih.gov
Innes
K E
KE
Roberts
J M
JM
Hoover
R N
RN
D000728:Androgens / Q000378:metabolism* / Q000502:physiology; D000735:Androstenedione / Q000097:blood / Q000502:physiology; D001943:Breast Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D009518:New York / Q000453:epidemiology; D016017:Odds Ratio; D010414:Pennsylvania / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011863:Radioimmunoassay; D012307:Risk Factors; D012737:Sex Factors
D000728:Androgens; D000735:Androstenedione