Marine cytotoxic macrolides haterumalides and biselides, and related natural products.
Marine animals and plants are rich sources of bioactive natural products. Haterumalides and biselides, isolated from Okinawan marine animals, are 14-membered macrolides with strong cytotoxicity against human cancer cell lines. This review highlights the isolation, structures, bioactivities, and total synthesis of haterumalides, biselides, and related natural products.
Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8571, Japan. kigoshi@chem.tsukuba.ac.jp
Hideo
H
Kigoshi
Ichiro
I
Hayakawa
D000085:Acetates / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000737:chemistry; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000085:Acetates; D000970:Antineoplastic Agents; D001688:Biological Products; D003603:Cytotoxins; C508031:FR177391; D006571:Heterocyclic Compounds; D007783:Lactones; D018942:Macrolides; C403892:oocydin A