New factors affecting bone remodeling.
Over the past few years the discovery of the mechanisms of osteoclast and osteoblast signaling and the relationship between bone resorption and osteogenesis has resulted in increasing our understanding of the process of bone remodeling. Recently new elements have been shown to be involved in the bone remodeling process. Leptin, produced by adipose tissue, regulates body mass by acting on the hypothalamic nuclei, and may modulate bone remodeling as well; sclerostin, responsible for the suppresion of bone formation. The gene encoding low-density lipoprotein receptor-related protein 5 is thought to regulate bone resorption. These molecules may become important tools in the development of therapeutic strategies for osteoporosis.
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