Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth.
OBJECTIVE
The study aim was to assess the prevalence of Helicobacter pylori infection in Egyptian schoolchildren and its effect on growth parameters.


METHODS
A cross-sectional population-based study was conducted among 286 schoolchildren (168 boys and 118 girls), with a mean age of 11.04 +/- 0.19 years, to determine the prevalence of H. pylori. The presence of the bacterium was assessed using the [13C]urea breath test. Relevant personal and socio-economic data on risk factors for infection were collected. Height and weight were analysed in relation to H. pylori infection.


RESULTS
The overall prevalence of H. pylori infection was 72.38%. Attending school in a socially deprived area and residing in an overcrowded home were the major risk factors for infection. Differences between infected and non-infected children were significant with regard to body weight and height (weight: 39.5 +/- 1.0 vs. 44.6 +/- 1.8 kg, P = 0.05; height: 139.9 +/- 1.3 vs. 144.2 +/- 2.1 cm; P = 0.009). The number of children (both boys and girls) falling below the 5th percentile of height-for-age was significantly higher in infected than non-infected children (P = 001), similarly for Z-scores for height-for-age below -2.0 (P = 0.003).


CONCLUSIONS
The results demonstrate not only that the prevalence of H. pylori infection is extremely high among Egyptian schoolchildren, but also that the adverse effects of the infection reach far beyond the stomach. Evidence of the burden of infection on growth failure is presented.
Mohammad
Mahmoud A
MA
Department of Nutrition, National Research Center, Giza - Dokki 12311, El Bouhous Str, Egypt.
Hussein
Laila
L
Coward
Andy
A
Jackson
Sarah J
SJ
D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001944:Breath Tests; D002648:Child; D003430:Cross-Sectional Studies; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006130:Growth Disorders / Q000453:epidemiology* / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D012923:Social Class