Hairy cell leukemia.
Hairy cell leukemia (HCL) is a chronic B-cell lymphoproliferative disorder characterized by pancytopenia and variable infiltration of the reticuloendothelial system with "hairy" lymphocytes. HCL is more common in men than women and has a median age of diagnosis of 52 yr. Typically, patients with HCL respond well to purine analog-based therapy. The purpose of this review will be to establish the current status of HCL with respect to its pathophysiology, diagnosis, management, and future directions.
Department of Haematology, University College Hospital Galway, Galway, Ireland.
Ronan
R
Swords
Francis
F
Giles
D006801:Humans; D007943:Leukemia, Hairy Cell / Q000175:diagnosis / Q000628:therapy