Leptin modulates the response to oleic acid in the pharynx.
Leptin released from the adipose tissues is known to inhibit obesity by regulating food intake. In this study, we investigated the effect of leptin on afferent nerve responses to fats and fatty acid in the pharyngolaryngeal region. The afferent nerve activities were recorded from the whole nerve bundle or pauci-fiber bundles of the pharyngeal branch of the glossopharyngeal nerve (GPN-ph) in Wistar normal and fatty rats. Oleic acid (long-chain fatty acid), mineral oil (nonfat oil) and safflower oil (vegetable oil; middle-chain fatty acid) were applied to the surface of pharyngolaryngeal mucous membrane. Oleic acid elicited vigorous stimulation of the GPN-ph activity in both normal and fatty rats but other oils had no significant effect on the activity. After intravenous administration of leptin (30 ng/kg, 1 ml), the response to oleic acid was significantly decreased in normal rats, whereas such a decrease was not found in fatty rats. These results are the first findings to indicate the existence of a suppressive mechanism of leptin on the response of the GPN-ph to fatty acid in normal rats, but that such a mechanism is lacking in fatty rats.
Kitagawa
Junichi
J
Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo 102-8159, Japan. kitagawa-j@tokyo.ndu.ac.jp
Shingai
Tomio
T
Kajii
Yuka
Y
Takahashi
Yoshihiro
Y
Taguchi
Yo
Y
Matsumoto
Shigeji
S
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D005930:Glossopharyngeal Nerve / Q000187:drug effects; D020738:Leptin / Q000378:metabolism*; D008899:Mineral Oil / Q000494:pharmacology; D009765:Obesity / Q000503:physiopathology; D019301:Oleic Acid / Q000494:pharmacology*; D010614:Pharynx / Q000187:drug effects* / Q000294:innervation; D051381:Rats; D017208:Rats, Wistar; D012450:Safflower Oil / Q000494:pharmacology
D020738:Leptin; D019301:Oleic Acid; D012450:Safflower Oil; D008899:Mineral Oil