Increased incidence of pituitary microadenomas in suicide victims.
BACKGROUND
Current data suggest an influence of the hypothalamic-pituitary-adrenal axis on suicidal behavior. The frequency of pituitary adenomas in suicide victims has not yet been investigated.


OBJECTIVE
The aim of this study was to assess whether the incidence of pituitary adenomas is correlated with suicide.


METHODS
Serial sections of 151 human pituitary glands obtained upon autopsy were examined microscopically. The glands were collected from 70 suicide victims and 81 subjects whose deaths were classified as unexpected or accidental (nonsuicidal group). The sections were stained with hematoxylin-eosin and the presence of adenoma was confirmed by immunostaining for collagen III.


RESULTS
In the suicidal group, pituitary microadenomas were found in 32 cases (47.7%), while in the nonsuicidal group microadenomas were detected in 15 cases (18.3%). The observed difference was statistically significant (p = 0.0003). The relative risk ratio of suicide in persons with pituitary adenomas was estimated at 1.9. Logistic regression analysis in a model controlled for age and sex showed that microadenomas constituted a unique risk factor in this model. The immunohistochemical phenotyping revealed a higher percentage of immunopositive (secreting) microadenomas in the nonsuicidal group as compared to the suicidal group (80.0 vs. 59.38%) and a predominance of growth hormone-secreting microadenomas in both groups. However, these differences as well as differences in the hormonal profiles of microadenomas between the groups were not significant.


CONCLUSIONS
These results suggest that pituitary adenomas belong to suicide risk factors.
Furgal-Borzych
Alicja
A
Department of Histology, Jagiellonian University Medical College, Krakow, Poland.
Lis
Grzegorz J
GJ
Litwin
Jan A
JA
Rzepecka-Wozniak
Ewa
E
Trela
Franciszek
F
Cichocki
Tadeusz
T
D000236:Adenoma / Q000453:epidemiology* / Q000378:metabolism / Q000523:psychology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000453:epidemiology* / Q000378:metabolism / Q000523:psychology*; D013405:Suicide / Q000523:psychology* / Q000706:statistics & numerical data