Role of gadd45 in myeloid cells in response to hematopoietic stress.
The gadd45 family of genes is rapidly induced by different stressors, including differentiation-inducing cytokines, and there is a large body of evidence that their cognate proteins are key players in cellular stress responses. Induction of gadd45 genes at the onset of myeloid differentiation suggested that Gadd45 protein(s) play a role in hematopoiesis, yet no apparent abnormalities were observed in either the bone marrow or peripheral blood compartments of mice deficient for either gadd45a or gadd45b. However, under conditions of hematological stress, including acute stimulation with cytokines, myelo-ablation and inflammation, both gadd45a-deficient and gadd45b-deficient mice exhibited deficiencies. This topic is discussed within the context of what is known about Gadd45 proteins in stress signaling, hematopoietic development and the innate immune response.
Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, 3307 N. Broad Street, Temple University School of Medicine, Philadelphia, PA 19140, USA. hoffman@temple.edu
Barbara
B
Hoffman
Dan A
DA
Liebermann
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D045744:Cell Line, Tumor; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D022423:Myeloid Cells / Q000378:metabolism*; D038042:Myelopoiesis; D000097642:GADD45 Proteins
D016207:Cytokines; D047908:Intracellular Signaling Peptides and Proteins; D000097642:GADD45 Proteins