Chemoenzymatic synthesis of feruloyl D-arabinose as a potential anti-mycobacterial agent.
The feruloyl esterase (StFaeC) produced by Sporotrichum thermophile transfered the feruloyl group to D: -arabinose using a mixture of n-hexane, t-butanol and water. About 45% conversion of D: -arabinose to the feruloylated derivative was achieved. The compound had an MIC value against Mycobacterium bovis BCG of 25 microg/ml.
Biotechnology Laboratory, School of Chemical Engineering, National Technical University of Athens, 5 Iroon Polytechniou Str, Zografou Campus, Athens, 15700, Greece.
Christina
C
Vafiadi
Evangelos
E
Topakas
Luke J
LJ
Alderwick
Gurdyal S
GS
Besra
Paul
P
Christakopoulos
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002265:Carboxylic Ester Hydrolases / Q000302:isolation & purification / Q000378:metabolism; D004187:Disaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D004951:Esterification; D009163:Mycobacterium bovis / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004187:Disaccharides; C089277:feruloyl arabinobiose; D002265:Carboxylic Ester Hydrolases; C070196:feruloyl esterase