p53 mutations are associated with dysplasia and progression of dysplasia in patients with Crohn's disease.
BACKGROUND
Mutations in the tumor suppressor gene p53 are associated with neoplasia in ulcerative colitis, but little is understood of their significance in Crohn's disease (CD).


OBJECTIVE
To explore p53 expression as a marker of neoplasia in CD patients.


METHODS
This is a retrospective review of CD patients who underwent p53 IHC staining in our center between 1995 and 2003. The p53 status was correlated to the presence and grade of neoplasia at the time of staining and in subsequent follow-up.


RESULTS
Fourteen CD patients had p53 assessment: eight were p53 positive and six were p53 negative. Seven of eight p53+ had dysplasia (six LGD, one HGD); one of six p53-had dysplasia (LGD) (P = 0.03). Four p53+ patients with follow-up had persistent dysplasia and two had progression to a higher grade. Three p53- patients with follow-up remained free of dysplasia.


CONCLUSIONS
This limited study shows that p53 over expression in CD patients is associated with dysplasia that may progress to a higher grade of neoplasia over time.
Nathanson
Jeffrey W
JW
Reva and David Logan Gastrointestinal Clinical Research Center at the University of Chicago, Chicago, IL, USA.
Yadron
Nicole E
NE
Farnan
Jeanne
J
Kinnear
Sydney
S
Hart
John
J
Rubin
David T
DT
D000328:Adult; D003424:Crohn Disease / Q000235:genetics* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment