Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage.
Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression.
LaMarca
Heather L
HL
Department of Molecular and Cellular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA. lamarca@bcm.edu
Rosen
Jeffrey M
JM
D066258:Amphiregulin; D001940:Breast / Q000254:growth & development* / Q000473:pathology; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology; D066255:EGF Family of Proteins; D004967:Estrogens / Q000494:pharmacology*; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*
C587848:AREG protein, human; D066258:Amphiregulin; D066255:EGF Family of Proteins; D004967:Estrogens; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins