Untangling klotho's role in calcium homeostasis.
klotho was first described as an aging gene and was later shown to be a regulator of phosphate and vitamin D metabolism, acting as a coreceptor for FGF23. Imura et al. (2007) now report that klotho also regulates calcium homeostasis.
Strewler
Gordon J
GJ
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. gordon_strewler@hms.harvard.edu
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism*; D006706:Homeostasis; D000090265:Klotho Proteins; D051379:Mice; D010710:Phosphates / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism
C000717428:Fgf23 protein, mouse; D010710:Phosphates; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins; D002118:Calcium