Relationship between serum lactate level and periventricular leukomalacia.
In a case control study, we evaluated the serum lactate levels during the early days of life in preterm infants with periventricular leukomalacia (PVL), who were presumed to have suffered injury around birth. Thirteen infants diagnosed by ultrasonography as suffering from cystic PVL during the neonatal period and 26 normally developed infants matched by gestational age were enrolled in the study. The serum lactate level was measured repeatedly during the 72 h after birth. The mean serum lactate levels on admission were 2.95+/-0.43 and 3.21+/-0.29 mmol/L in the PVL and control groups, respectively. There was no statistically significant difference in the serum lactate level between the groups at any point during the first 72 h after birth. In conclusion, the serum lactate level was not elevated in preterm infants with PVL suggesting that the serum lactate level is not a useful predictor for the development of PVL in infants.
Department of Pediatrics, Anjo Kosei Hospital, 28 Tokoubann, Anjo-cho, Anjo-shi, Aichi 486-8510, Japan. kidokoro@wc4.so-net.ne.jp
Hiroyuki
H
Kidokoro
Masaki
M
Shimizu
Hirofumi
H
Kimoto
Akihisa
A
Okumura
Masahiro
M
Hayakawa
Kazuyoshi
K
Watanabe
Tsutomu
T
Ohno
D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood*; D019344:Lactic Acid / Q000097:blood*; D007969:Leukomalacia, Periventricular / Q000097:blood*; D008297:Male; D012189:Retrospective Studies
D019344:Lactic Acid