Influence of pectins on preparation characteristics of lactoferrin bioadhesive tablets.
For the treatment of chronic inflammation in the oral cavity, we attempted to develop bioadhesive tablets of bovine lactoferrin (B-LF). Pectin was used as a bioadhesive polymer, and the influence of the degree of esterification and the molecular weight of pectins on the characteristics of B-LF tablets were investigated. Concerning bioadhesive force, a tendency increasing the value according to increase of the esterification of the pectin was confirmed. Sustained release of B-LF from the tablets was observed as the esterification increased, and a possibility for prediction of the time required to release 50% of B-LF by using the equation given by the degree of esterification and the logarithm of the molecular weight was suggested. Pectin cross-linked with Ca(2+) (Ca-PC) was also used for the preparation of the B-LF tablets. Prolonged release of B-LF from the tablets was observed as the Ca(2+) in Ca-PC increased. Our findings suggest that pectin with a high degree of esterification is suitable as a bioadhesive polymer since high bioadhesive force and sustained release are shown. Furthermore, a possibility that the B-LF release could be controlled by adjusting the Ca(2+) concentration in Ca-PC was suggested.
Department of Drug Delivery Research, Hoshi University, Tokyo, Japan.
Chikako
C
Takeda
Yuri
Y
Takahashi
Isamu
I
Seto
Genji
G
Kawano
Kozo
K
Takayama
Hiraku
H
Onishi
Yoshiharu
Y
Machida
D000042:Absorption; D000269:Adhesives; D000818:Animals; D004339:Drug Compounding; D005079:Excipients; D066298:In Vitro Techniques; D007781:Lactoferrin / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D008566:Membranes / Q000737:chemistry; D051379:Mice; D008970:Molecular Weight; D010368:Pectins / Q000737:chemistry*; D012044:Regression Analysis; D012995:Solubility; D013607:Tablets; D013718:Tensile Strength; D014783:Viscosity
D000269:Adhesives; D005079:Excipients; D013607:Tablets; D010368:Pectins; D007781:Lactoferrin