3-Hydroxy-4-methoxyindolomorphinans as delta opioid selective ligands.
Previous studies showed that 4-hydroxy-3-methoxyindolomorphinans had variable delta opioid affinity and selectivity. Herein, we show that the 3,4-dimethoxy analogs possessed similar low affinity, whereas the 3-hydroxy-4-methoxy analogs showed excellent delta opioid affinity and selectivity comparable with the parent indolomorphinans.
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA.
Trudy A
TA
Smith
Linn N
LN
Thatcher
Andrew
A
Coop
D008024:Ligands; D009019:Morphinans / Q000494:pharmacology*; D017465:Receptors, Opioid, delta / Q000187:drug effects*; D013379:Substrate Specificity
D008024:Ligands; D009019:Morphinans; D017465:Receptors, Opioid, delta