[Quantitive study of interleukin 1beta in periapical exudates of chronic periapical periodontitis in the course of root canal therapy].
OBJECTIVE
To evaluate the relationship between IL-1beta and clinical findings of chronic apical periodontitis and to explore the function of IL-1beta during the endodontic interappointment flare-ups.


METHODS
Periapical exudates samples were obtained from 19 teeth suffering from endodontic flare-ups after root canal preparation and 20 teeth without any symptoms and signs at the second visit after root canal preparation. The levels of IL-1beta were determined by ELISA and the data was analyzed by SAS6.12 software package.


RESULTS
Significantly higher levels of IL-1beta were found in periapical exudates from teeth suffering from endodontic flare-ups than that before canal preparation(P<0.001). The mean IL-1beta levels significantly decreased following the endodontic therapy if there were no symptom at the second visit (P<0.001).


CONCLUSIONS
The level of IL-1beta in the exudates of root canals were related with the exist of infection which might take an active part in the occurrence of endodontic interappointment flare-up.
Yan
Pei-fang
PF
Department of Endodontics, College of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Research Institute of Stomatology, Shanghai 200011, China.
Liang
Jing-ping
JP
Chen
Wei-min
WM
Gu
Shen-sheng
SS
D006801:Humans; D053583:Interleukin-1beta; D008963:Molar; D010485:Periapical Periodontitis / Q000378:metabolism*; D010518:Periodontitis; D018915:Root Canal Preparation; D012390:Root Canal Therapy
D053583:Interleukin-1beta