Evaluation of the use of thermal thresholds to investigate NSAID analgesia in a model of inflammatory pain in cats.
This study evaluated thermal threshold (TT) testing for investigation into NSAID analgesia in cats. Seven cats participated in two crossover studies. TTs were measured on thoracic skin using a device developed specifically for cats. Skin temperature was recorded, then the heater activated. At the behavioural end point heating was stopped and temperature (=TT) recorded. In part 1, TTs were measured following subcutaneous (SC) ketoprofen or saline. In part 2, the process was repeated after intradermal kaolin induced mild inflammation at the test site. TTs were measured before treatment and two hourly for 24 h. In part 1, skin temperature did not change but in part 2 it increased more after saline than ketoprofen. TT did not change significantly after any treatment. However, after ketoprofen TT fell below the 95% confidence interval (CI) in part 1 and increased above it in part 2. The method detected some NSAID effects but is unlikely to be sufficiently sensitive for study of NSAID analgesia.
Taylor Monroe, Ely, UK. polly@taylormonroe.co.uk
Polly M
PM
Taylor
Sheilah A
SA
Robertson
Michael J
MJ
Dixon
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy* / Q000473:pathology; D002415:Cats; D018592:Cross-Over Studies; D005260:Female; D006358:Hot Temperature; D007249:Inflammation / Q000188:drug therapy / Q000662:veterinary*; D007660:Ketoprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D010147:Pain Measurement / Q000662:veterinary*; D017288:Pain Threshold; D011237:Predictive Value of Tests
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen