Diastereoselective formal synthesis of a monoterpene alkaloid, (-)-incarvilline.
Diastereoselective formal synthesis of a monoterpene alkaloid, (-)-incarvilline, the key intermediate for the synthesis of (-)-incarvillateine, was achieved by using an intramolecular Pauson-Khand reaction of (S)-N-[(E)-2-butenyl]-N-(3-butynyl-2-methoxymethoxy)-p-toluenesulfonamide as a key step.
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan. honda@hoshi.ac.jp
Toshio
T
Honda
Kyosuke
K
Kaneda
D000470:Alkaloids / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D039821:Monoterpenes / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
D000470:Alkaloids; D039821:Monoterpenes; C400141:incarvillateine