3-Hydroxy-4-methoxyindolomorphinans as delta opioid selective ligands.
Previous studies showed that 4-hydroxy-3-methoxyindolomorphinans had variable delta opioid affinity and selectivity. Herein, we show that the 3,4-dimethoxy analogs possessed similar low affinity, whereas the 3-hydroxy-4-methoxy analogs showed excellent delta opioid affinity and selectivity comparable with the parent indolomorphinans.
Smith
Trudy A
TA
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA.
Thatcher
Linn N
LN
Coop
Andrew
A
D008024:Ligands; D009019:Morphinans / Q000494:pharmacology*; D017465:Receptors, Opioid, delta / Q000187:drug effects*; D013379:Substrate Specificity
D008024:Ligands; D009019:Morphinans; D017465:Receptors, Opioid, delta