Relation between hypercholesterolaemia and vascular endothelial microinflammation.
We investigated the correlation between hypercholesterolaemia and oxidative stress and P-selectin and interleukin-6 (IL-6) as markers for endothelial status. We studied 40 Egyptian adults with asymptomatic hypercholesterolaemia and 20 age- and sex-matched controls. Lipid peroxidation was significantly higher (P < 0.001) in the study group and positively correlated with cholesterol (P < 0.001) and low-density lipoprotein (LDL) (P < 0.002). Glutathione peroxidase activity was also significantly higher (P < 0.001) with positive correlation with cholesterol (P < 0.001) and LDL (P < 0.001). Markers for endothelial cell function were significantly higher in the study group (P < 0.001) with a positive correlation with cholesterol (P < 0.001) and LDL (P < 0.001). Hypercholesterolaemia causes endothelial microinflammation, and P-selectin and IL-6 may also be risk factors for cardiovascular disease.
Department of Medical Physiology, National Research Centre, Giza, Egypt. amanyse@hotmail.com
A S
AS
Elwakkad
S I
SI
Mohamed
M
M
Fathalla
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004534:Egypt; D004730:Endothelium, Vascular / Q000276:immunology / Q000293:injuries / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000276:immunology / Q000378:metabolism; D007249:Inflammation; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D015227:Lipid Peroxidation / Q000276:immunology; D008297:Male; D018384:Oxidative Stress / Q000276:immunology; D019007:P-Selectin / Q000097:blood / Q000276:immunology; D012307:Risk Factors; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D015415:Biomarkers; D008078:Cholesterol, LDL; D015850:Interleukin-6; D019007:P-Selectin; D017392:Thiobarbituric Acid Reactive Substances; D002784:Cholesterol; D005979:Glutathione Peroxidase