CD44 and hyaluronan help mesenchymal stem cells move to a neighborhood in need of regeneration.
Prevention of normal interactions between CD44 cell-surface receptors on cultured mesenchymal stem cells and hyaluronic acid in the renal interstitial matrix has been described as reducing the ability of these cells in vivo to localize to regions with acute tubular injury. Understanding processes such as this might one day help us to target exogenous cells to assist renal regeneration.
In Situ Hybridisation Service, Histopathology Unit, Cancer Research UK London Research Institute, London, United Kingdom. richard.poulsom@cancer.org.uk
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D058186:Acute Kidney Injury / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D000818:Animals; D000911:Antibodies, Monoclonal; D001854:Bone Marrow Cells / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects; D004195:Disease Models, Animal; D005990:Glycerol; D018960:Hyaluronan Receptors / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000378:metabolism* / Q000494:pharmacology; D007684:Kidney Tubules / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D012038:Regeneration
D000911:Antibodies, Monoclonal; C476399:Cd44 protein, mouse; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid; D005990:Glycerol