[Pemphigus vulgaris and intraepithelial neoplasia localized to the vagina].
BACKGROUND
Involvement of the vaginal mucosa in pemphigus vulgaris is a rare occurrence. Here we report an original case that resulted in discovery of intra-epithelial neoplasia at the same site.


METHODS
A 63 year-old woman was followed for 18 years for pemphigus vulgaris treated with prednisone, initially in combination with azathioprine. An erosive lesion was discovered in the pouch of Douglas during routine gynecological examination and demonstrated the histological features of pemphigus, despite remission of the disease at other sites. In spite of resumption of azathioprine and prednisone, the vaginal lesion continued to spread. A further biopsy revealed intra-epithelial vaginal neoplasia together with images of suprabasal cleavage and acantholysis. Surgical removal was carried out.


CONCLUSIONS
Intra-epithelial carcinoma associated with pemphigus vulgaris has been described in rare cases in the cervix but never in the vagina.
Service de Dermatologie, CHU d'Angers.
F
F
Hoareau
A
A
Croue
J
J
Marchetta
S
S
Kettani
J-L
JL
Verret
D001379:Azathioprine / Q000627:therapeutic use; D002278:Carcinoma in Situ / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D010392:Pemphigus / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D011241:Prednisone / Q000627:therapeutic use; D016896:Treatment Outcome; D014621:Vagina / Q000601:surgery; D014625:Vaginal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone