Neuroendocrine tumor in the lung of a captive black spider monkey (Ateles paniscus).
This paper describes a neuroendocrine (NE) tumor of the lung that was observed during the necropsy of a 14-year-old female black spider monkey (Ateles paniscus) with sudden death. Grossly, multifocal firm and coalescing nodular masses were observed in the lung. The histological examination showed the tumor to be an typical NE tumor with polygonal cells grouped in small solid aggregates, with regularly sized, spherical, centrally placed nuclei with modest, lightly granular cytoplasm suspended in a fibrovascular stroma. The immunohistochemical examination revealed the tumor to be positive for cytokeratin, chromogranin A and synaptophysin, and negative for CD56. To the best of our knowledge, this is the first report of NE tumor in the lung of the black spider monkey.
Cho
Ho-Seong
HS
Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea.
Kim
Yeong-Seob
YS
Choi
Chan
C
Lee
Jae-Hyuk
JH
Kurkure
Nitin V
NV
Subramanian
Madhan
M
Park
Nam-Yong
NY
D000818:Animals; D000836:Animals, Zoo; D053819:Atelinae; D017809:Fatal Outcome; D005260:Female; D006651:Histocytochemistry / Q000662:veterinary; D008175:Lung Neoplasms / Q000473:pathology / Q000662:veterinary*; D008992:Monkey Diseases / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000662:veterinary*