Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines.
In the present research, a series of 5,6-bis aryl 1,2,4-triazines 5a~5f were synthesized by condensation of various benzils 4a~4f with aminoguanidine bicarbonate and were screened in vivo, for their anticonvulsant and neurotoxicity studies. Compounds 5a, 5b and 5d were found to be potent molecules of this series, when compared with the reference drugs phenytoin sodium, diazepam and lamotrigine. The structures of these compounds were established by IR, (1)H NMR, (13)C NMR and mass spectroscopic data.
Mallikarjuna
B P
BP
Department of Medicinal Chemistry, St. Johns Pharmacy College, Bangalore-560040, Karnataka, India.
Suresh Kumar
G V
GV
Sastry
B S
BS
Nagaraj
Manohara
K P
KP
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012640:Seizures / Q000517:prevention & control; D021241:Spectrometry, Mass, Electrospray Ionization; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity
D000927:Anticonvulsants; D014227:Triazines