[Cp*IrCl2]2-catalyzed indirect functionalization of alcohols: novel strategies for the synthesis of substituted indoles.
We report novel iridium(III)-catalyzed reactions that afford substituted indoles via the indirect functionalization of alcohols via C-3 selective alkylation of indoles with alcohols and a one-pot cascade strategy from amino- or nitro-phenyl ethyl alcohols, which incorporates oxidative cyclization and C-3 alkylation.
Molecular, Innovation, Diversity and Automated Synthesis Centre, Department of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom.
Simon
S
Whitney
Ronald
R
Grigg
Andrew
A
Derrick
Ann
A
Keep
D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis*; D007495:Iridium
D000438:Alcohols; D007211:Indoles; D007495:Iridium