Radioiodine therapy and subsequent pregnancy.
OBJECTIVE
To evaluate abortion and fetal congenital anomaly rates in women previously submitted to radioiodine therapy for differentiated thyroid carcinoma.


METHODS
A case-control study of 108 pregnant women, 48 cases whose pregnancies were evaluated after they had undergone radioiodine therapy for differentiated thyroid carcinoma, and the control group consisted of 60 healthy pregnant women.


RESULTS
Of a total of 66 pregnancies, 14 conceived within the first year, 51 one or more years after the last administration of 131I, the medical record of one patient was not available. The interval between the last radioiodine therapy administration and conception ranged from 1 month to 10 years. There were a total of 4 miscarriages, 2 of them for unknown reasons. There was one case of congenital anomaly and two preterms birth. Nine women presented the following pregnancy events: placental insufficiency, hypertensive crisis, placental detachment, risk of miscarriage, preterm labour and four miscarriages. No statistical difference was observed between the studied and control groups.


CONCLUSIONS
Radioiodine was followed by no significant increase in untoward effects in neither the pregnancy nor the offspring.
Department of Endocrinology and Nuclear Medicine, Hospital Universitário Clementino Fraga Filho, Rua Joseph Zogaib 55/203, 29101-270 Vila Velha, ES. loloi@zaz.com.br
Carmen Dolores G
CD
Brandão
Angélica E
AE
Miranda
Nilson Duarte
ND
Corrêa
Lino
L
Sieiro Netto
Rossana
R
Corbo
Mario
M
Vaisman
D000016:Abnormalities, Radiation-Induced / Q000209:etiology*; D000022:Abortion, Spontaneous; D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011256:Pregnancy Outcome; D011877:Radionuclide Imaging; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*
D007457:Iodine Radioisotopes