Antifungal potential of disulfiram.
Disulfiram, an alcohol antagonistic drug has been on the market since 1949 with 80% bioavailability and an established safety profile. Recently it has been reported as a P-glycoprotein efflux pump modulator. Herein we report its antifungal potential. The MIC50 and MIC90 of disulfiram for yeast isolates is 4 and 8 microg/ml, respectively, and the MIC range is 1-16 micro g/ml for both fluconazole sensitive and resistant strains. Interestingly, disulfiram also showed fungicidal activity on Aspergillus spp. with MIC50 and MIC90 of 2 and 8 microg/ml, respectively.
Khan
Seema
S
Department of Infectious Diseases, New Drug Discovery Research, R and D III, Sarhaul, Sector-18, Ranbaxy Research Laboratories, Gurgaon-122001, India.
Singhal
Smita
S
Mathur
Tarun
T
Upadhyay
Dilip J
DJ
Rattan
Ashok
A
D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D004221:Disulfiram / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015003:Yeasts / Q000187:drug effects
D000935:Antifungal Agents; D004221:Disulfiram