Biodistribution of quantum dot nanoparticles in perfused skin: evidence of coating dependency and periodicity in arterial extraction.
Arterial extraction of quantum dots (QD) assayed by fluorescence or inductively coupled plasma (ICP) emission spectrometry were studied after infusion into isolated perfused skin. Extraction was mathematically modeled using three linear differential equations. COOH-coated QD had greater tissue deposition, assessed both by model prediction and laser confocal scanning microscopy, than did QD-PEG. Both QD had a unique periodicity in arterial extraction never observed with drug infusions, suggesting a potentially important nanomaterial behavior that could affect systemic disposition.
Center for Chemical Toxicology Research and Pharmacokinetics, and Biomathematics Program, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.
Hyun A
HA
Lee
Mudassar
M
Imran
Nancy A
NA
Monteiro-Riviere
Vicki L
VL
Colvin
William W
WW
Yu
Jim E
JE
Riviere
D000818:Animals; D001158:Arteries / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004058:Diffusion; D010477:Perfusion; D045663:Quantum Dots; D012867:Skin / Q000098:blood supply* / Q000737:chemistry*; D012869:Skin Absorption / Q000502:physiology*; D013552:Swine; D014018:Tissue Distribution
D020099:Coated Materials, Biocompatible