Effect of neurolytic celiac plexus block guided by computerized tomography on pancreatic cancer pain.
The efficacy of neurolytic coeliac plexus block (NCPB) guided by computerized tomography (CT) was compared with pharmacological therapy in the treatment of pain due to pancreatic cancer. The study involved 56 patients who were placed randomly in either a NCPB group and pharmacological therapy group. At day 1, 7, and 14, the visual analogue scale (VAS) pain scores of the NCPB group were significantly lower than those of the pharmacological therapy group (P < 0.01), with values of 1.3 +/- 0.8 versus 4.1 +/- 0.9, 1.7 +/- 1.1 versus 3.1 +/- 1.1, and 2.0 +/- 1.1 versus 2.9 +/- 0.6, respectively. However, the differences in the improvement of quality of life (QOL) between two groups were not statistically significant. Moreover, the dose of opioid was significantly lower in the patients of group 1 than those of group 2, while the complications related to NCPB were transient. We therefore concludes that CT-guided NCPB with alcohol is an effective and safe modality in the management of intractable pancreatic cancer pain.
Zhang
Chun-Lei
CL
Department of Pain, Xuanwu Hospital, Capital Medical University, Xuanwu District, Beijing 100053, China.
Zhang
Ting-Jie
TJ
Guo
Yu-Na
YN
Yang
Li-Qiang
LQ
He
Ming-Wei
MW
Shi
Jing-Zhe
JZ
Ni
Jia-Xiang
JX
D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000779:Anesthetics, Local / Q000008:administration & dosage; D002447:Celiac Plexus / Q000000981:diagnostic imaging / Q000187:drug effects*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use; D009407:Nerve Block; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D059408:Pain Management; D010190:Pancreatic Neoplasms / Q000150:complications*; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D009020:Morphine; D008012:Lidocaine