Helicobacter pylori primary resistant strains over 11 years in French children.
The yearly prevalence between 1994 and 2005 of primary resistance to amoxicillin, metronidazole, and clarithromycin of 377 Helicobacter pylori strains isolated from children was studied. All the H. pylori strains were susceptible to amoxicillin, 138/377 (36.7%) were resistant to metronidazole, 86/377 (22.8%) to clarithromycin, and 30/377 (7.9%) to both metronidazole and clarithromycin. Over the entire period, resistance to clarithromycin did not change, whereas metronidazole resistance decreased significantly from 43.3% (1994-1998) to 32% (1999-2005), P = 0.001.
Kalach
Nicolas
N
Clinique de Pédiatrie Saint Antoine, Hôpital Saint Vincent de Paul, BD de Belfort, Université Catholique de Lille, 59020 Lille, France.
Serhal
Lydia
L
Asmar
Edgar
E
Campeotto
Florence
F
Bergeret
Michel
M
Dehecq
Eric
E
Spyckerelle
Claire
C
Charkaluk
Marie-Laure
ML
Decoster
Anne
A
Dupont
Christophe
C
Raymond
Josette
J
D000293:Adolescent; D000658:Amoxicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D017291:Clarithromycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005260:Female; D005602:France / Q000453:epidemiology; D016481:Helicobacter Infections / Q000453:epidemiology / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013997:Time Factors
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D000658:Amoxicillin; D017291:Clarithromycin