Numerical assessment of radiation binary targeted therapy for HER-2 positive breast cancers: advanced calculations and radiation dosimetry.
In our previous publication (Mundy et al 2006 Phys. Med. Biol. 51 1377) we have described the theoretical assessment of our novel approach in radiation binary targeted therapy for HER-2 positive breast cancers and summarized the future directions in this area of research. In this paper we advanced the numerical analysis to show the detailed radiation dose distribution for various neutron sources in combination with the required boron concentration and allowed radiation skin doses. We once again proved the feasibility of the concept and will use these data and conclusions to start with the experimental verifications.
Purdue University, School of Nuclear Engineering, 400 Central Drive, West Lafayette, IN 47907-2017, USA.
Manuel L
ML
Sztejnberg Gonçalves-Carralves
Tatjana
T
Jevremovic
D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*
D018719:Erb-b2 Receptor Tyrosine Kinases