[Interleukin-4 and cardiac fibrosis in patients with heart failure].
Interleukin-4 (IL-4) stimulates inflammatory responses, activates collagen synthesis, promotes fibrosis progression, and inhibits the production of inflammatory cytokines. We studied the relationship between the urinary IL-4 level and levels of markers of cardiac fibrosis and left ventricular volume in 98 patients with heart failure (HF). The left ventricular end-systolic volume index (LVESVI) and left ventricular end-diastolic volume index (LVEDVI) were calculated, and IL-4, tumor necrosis factor-alpha (TNF-alpha), IL-6, and aminoterminal propeptide of procollagen type III (PIIINP) levels were recorded. Comparison of urinary IL-4 and PIIINP levels in patients and control subjects gave values of 12 (12) pg/mL and 4 (3) pg/mL (P<.0001), respectively, and 5 (2) ng/mL and 4 (1) ng/mL (P<.0001), respectively. The IL-4 level correlated with LVESVI and LVEDVI (r = -0.22, P<.05), and with PIIINP (r = 0.24, P<.05). In patients with hypertensive cardiomyopathy, there was a good correlation between IL-4 and PIIINP levels (r = 0.7, P<.01). Correlations were also observed between IL-4 and TNF-alpha (r = 0.3, P<.01) and IL-6 (r = 0.5, P<.0001). The urinary IL-4 level correlated with cardiac fibrosis and remodeling in patients with HF. The relationship was stronger in those with hypertensive cardiomyopathy.
Roselló-Lletí
Esther
E
Unidad de Cardiología, Centro de Investigación Hospital La Fe, Valencia, España.
Rivera
Miguel
M
Bertomeu
Vicente
V
Cortés
Raquel
R
Jordán
Alejandro
A
González-Molina
Andrés
A
D000368:Aged; D005260:Female; D005355:Fibrosis; D006333:Heart Failure / Q000150:complications / Q000473:pathology* / Q000652:urine*; D006801:Humans; D015847:Interleukin-4 / Q000652:urine*; D008297:Male; D009206:Myocardium / Q000473:pathology*
D015847:Interleukin-4