Allogeneic stem cells seeded tissue engineered bladder: a possible alternative for bladder reconstruction and treatment to bladder cancer.
Bladder cancer remains a difficult management problem, because of the high recurrence rate or the functional disorder of bladder post radical cystectomy. The autologous tissue engineering techniques have been advanced enough to reconstruct functional bladders for patients with myelomeningocele, but not capable for bladder cancer patients. On the other hand, allogeneic stem cells share the same multipotential, self-renewing and multi differentiated abilities with autologous ones, and would present anti-tumor effects when transplanted to recipients. Since the stem cells seeded tissue engineering techniques for bladder regeneration have already been feasible, a hypothesis was then proposed that the allogeneic stem cells seeded tissue engineered bladder would be a possible alternative for functional bladder reconstructions and treatments for bladder cancer recurrences and latent metastases postoperatively.
Yinan
Zhang
Z
Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Guomin
Wang
W
D000818:Animals; D021522:Bioartificial Organs; D020350:Graft vs Tumor Effect / Q000276:immunology; D006801:Humans; D051379:Mice; D008954:Models, Biological; D039902:Multipotent Stem Cells / Q000276:immunology / Q000637:transplantation*; D023822:Tissue Engineering / Q000379:methods*; D014184:Transplantation, Homologous; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000601:surgery*