Rosai-Dorfman disease of the breast mimicking cancer.
Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy is a rare proliferative histiocytic disorder of the lymph nodes. Extranodal involvement occurs in a considerable number of cases; however, involvement of the breast is very rare, and it is even rarer for the lesion to be localized in the breast alone without affecting any other sites. This report describes the case of a 50-year-old Brazilian woman with a lump confined to her left breast that had clinical and radiological characteristics indistinguishable from cancer. The proliferation of histiocytes, displaying lymphophagocytosis and an S-100 protein immunophenotype on a core biopsy of the lesion, led to a diagnosis of Rosai-Dorfman disease and permitted conservative therapy. Recognition of this rare condition, when occurring at an unexpected site such as the breast, is difficult, and the correct diagnosis is important prior to therapeutic management.
da Silva
Benedito Borges
BB
Department of Gynecology, Federal University of Piauí, Teresina, Piauí, Brazil. beneditoborges@globo.com
Lopes-Costa
Pedro Vitor
PV
Pires
Cleicilene Gomes
CG
Moura
Clériston Silva
CS
Borges
Rafael Soares
RS
da Silva
Raimundo Gerônimo
RG
D018949:Antigens, CD1 / Q000032:analysis; D001941:Breast Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D005260:Female; D006644:Histiocytes / Q000737:chemistry / Q000473:pathology*; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis; D016896:Treatment Outcome
D018949:Antigens, CD1; C419393:CD1a antigen; D009418:S100 Proteins