Intravascular large B-cell lymphoma of the uterus presenting as fever of unknown origin (FUO) and revealed by FDG-PET.
Non-Hodgkin's lymphoma (NHL) is a common cause of Fever of Unknown Origin (FUO) but the presentation as a gynaecologic malignancy is exceedingly rare. To our knowledge, this represents the first report of an intravascular large B-cell lymphoma of the uterus presenting with fever of unknown origin. After a standard clinical work-up for FUO, the endometrial curettage directed by the finding of a localized fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) hot spot in the pelvic area, yielded material revealing an intr avascular B-cell lymphoma. A total abdominal hysterectomy confirmed the presence of an intravascular large B-cell lymphoma in the lumina of small blood vessels of the uterus.
Lannoo
L
L
Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Belgium.
Smets
S
S
Steenkiste
E
E
Delforge
M
M
Moerman
P
P
Stroobants
S
S
Knockaert
D
D
Amant
F
F
D017809:Fatal Outcome; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000150:complications / Q000000981:diagnostic imaging*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D008875:Middle Aged; D049268:Positron-Emission Tomography; D014594:Uterine Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D014599:Uterus / Q000098:blood supply*; D019043:Vascular Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*