The application of exposure therapy and D-cycloserine to the treatment of anorexia nervosa: a preliminary trial.
OBJECTIVE
Novel approaches to the treatment of anorexia nervosa (AN) are needed. This preliminary study examined the utility and safety of an exposure therapy intervention and D-cycloserine (DCS) in a population of patients with AN.


METHODS
Eleven participants completed a series of 6 laboratory meals, including pre- and post-exposure test meals and four exposure sessions. Participants were randomly assigned to receive either DCS or placebo in double-blind fashion before each of the 4 exposure sessions. These results were compared to data from a previously studied group of patients who received treatment as usual.


RESULTS
Total caloric intake increased significantly from the baseline meal session to the post-test meal session in the patients who received the exposure therapy intervention. Caloric intake did not increase significantly in the comparison group.


CONCLUSIONS
These data suggest that an exposure therapy intervention specifically focused on meal consumption may be helpful in increasing intake of a test meal.
College of Physicians & Surgeons of Columbia University, New York, NY 10032, USA.
Joanna
J
Steinglass
Robyn
R
Sysko
Janet
J
Schebendach
Allegra
A
Broft
Michael
M
Strober
B Timothy
BT
Walsh
D000328:Adult; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D001008:Anxiety Disorders / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D015992:Body Mass Index; D003131:Combined Modality Therapy; D003523:Cycloserine / Q000627:therapeutic use*; D003887:Desensitization, Psychologic; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects; D018690:Excitatory Amino Acid Agonists / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010147:Pain Measurement; D010343:Patient Admission; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*
D018690:Excitatory Amino Acid Agonists; D016194:Receptors, N-Methyl-D-Aspartate; D003523:Cycloserine