Enantioselective synthesis of pachastrissamine (jaspin B) using dirhodium(II)-catalyzed C-H amination and asymmetric dihydroxylation as key steps.
Enantioselective total synthesis of anhydrophytosphingosine pachastrissamine (jaspin B) was achieved using Sharpless asymmetric dihydroxylation and dirhodium(II)-catalyzed C-H amination as key steps.
Yakura
Takayuki
T
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan. yakura@pha.u-toyama.ac.jp
Sato
Seiichi
S
Yoshimoto
Yuya
Y
D000586:Amination; D000818:Animals; D002384:Catalysis; D006900:Hydroxylation; D007202:Indicators and Reagents; D011161:Porifera / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000737:chemistry; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; C468594:pachastrissamine; D012238:Rhodium; D013110:Sphingosine