Atrial natriuretic peptide and related peptides.
In recent years, biomarkers have been recognized as important tools for diagnosis, risk stratification, and therapeutic decision-making in cardiovascular diseases. Currently, the clinical potential of several natriuretic peptides is under scientific investigation. The well-known counter-regulatory hormones are atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis natriuretic peptide (DNP) and urodilatin, which play an important role in the homeostasis of body fluid volume. ANP and BNP have already been demonstrated to have diagnostic usefulness in a great number of studies, which have progressed from bench to bedside. This article summarizes existing data on ANP and related peptides in cardiovascular and other disorders, and outlines the potential clinical usefulness of these markers.
Division of Applied Cachexia Research, Center for Cardiovascular Research, Charité Campus Mitte, Berlin, Germany.
Yoshihiro J
YJ
Akashi
Jochen
J
Springer
Mitja
M
Lainscak
Stefan D
SD
Anker
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000032:analysis*; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000175:diagnosis*; D004546:Elapid Venoms / Q000032:analysis; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007674:Kidney Diseases / Q000175:diagnosis*; D020097:Natriuretic Peptide, Brain / Q000032:analysis; D020098:Natriuretic Peptide, C-Type / Q000032:analysis; D010446:Peptide Fragments / Q000032:analysis; D010455:Peptides / Q000032:analysis
D015415:Biomarkers; C075597:Dendroaspis natriuretic peptide; D004546:Elapid Venoms; D036341:Intercellular Signaling Peptides and Proteins; D010446:Peptide Fragments; D010455:Peptides; D020097:Natriuretic Peptide, Brain; D020098:Natriuretic Peptide, C-Type; C056452:Ularitide; D009320:Atrial Natriuretic Factor