Nucleoside reverse-transcriptase inhibitor dosing errors in an outpatient HIV clinic in the electronic medical record era.
Information on antiretroviral dosing errors among health care providers for outpatient human immunodeficiency virus (HIV)-infected patients is lacking. We evaluated factors associated with nucleoside reverse-transcriptase inhibitor dosing errors in a university-based HIV clinic using an electronic medical record. Overall, older age, minority race or ethnicity, and didanosine use were related to such errors. Impaired renal function was more common in older patients and racial or ethnic minorities and, in conjunction with fixed-dose combination drugs, contributed to the higher rates of errors in nucleoside reverse-transcriptase inhibitor dosing. Understanding the factors related to nucleoside reverse-transcriptase inhibitor dosing errors is an important step in the building of preventive tools.
Willig
James H
JH
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, USA. jwillig@uab.edu
Westfall
Andrew O
AO
Allison
Jeroan
J
Van Wagoner
Nicholas
N
Chang
Pei-Wen
PW
Raper
James
J
Saag
Michael S
MS
Mugavero
Michael J
MJ
D000328:Adult; D000367:Age Factors; D015331:Cohort Studies; D016049:Didanosine / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D011307:Drug Prescriptions; D005006:Ethnicity; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006785:Hospitals, University; D006801:Humans; D007396:Internship and Residency; D007676:Kidney Failure, Chronic; D008297:Male; D008485:Medical Audit; D016347:Medical Records Systems, Computerized / Q000592:standards / Q000706:statistics & numerical data*; D008508:Medication Errors / Q000706:statistics & numerical data*; D009722:Nurse Practitioners; D010044:Outpatient Clinics, Hospital; D017410:Practice Guidelines as Topic; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*
D004338:Drug Combinations; D018894:Reverse Transcriptase Inhibitors; D016049:Didanosine