Self-assembly of a cyclobutane beta-tetrapeptide to form nanosized structures.
A beta-tetrapeptide made up of homochiral cyclobutane residues displays conformational bias in solution prompted by the formation of intramolecular hydrogen bonds. Moreover, this compound self-assembles to produce nanosized fibrils and, in some media, it also forms a gel. The combination of NMR, TEM, AFM, and theoretical calculations has proven to be very useful in obtaining insight into the details of these new structures.
Departament de Química, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Federico
F
Rúa
Stéphanie
S
Boussert
Teodor
T
Parella
Ismael
I
Díez-Pérez
Vicenç
V
Branchadell
Ernest
E
Giralt
Rosa M
RM
Ortuño
D003503:Cyclobutanes / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry
D003503:Cyclobutanes; D009842:Oligopeptides; D012996:Solutions