Avian proteomics: advances, challenges and new technologies.
Proteomics is defined as an analysis of the full complement of proteins of a cell or tissue under given conditions. Avian proteomics, or more specifically chicken proteomics, has focussed on the study of individual tissues and organs of interest to specific researchers. Researchers have looked at skeletal muscle and growth, and embryonic development and have performed initial studies in avian disease. Traditional proteomics involves identifying and cataloguing proteins in a cell and identifying relative changes in populations between two or more states, be that physiological or disease-induced states. Recent advances in proteomic technologies have included absolute quantification, proteome simplification and the ability to determine the turnover of individual proteins in a global context. This review discusses the current developments in this relatively new field, new technologies and how they may be applied to biological questions, and the challenges faced by researchers in this ever-expanding and exciting field.
Doherty
M K
MK
Protein Function Group, Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool, UK.
McLean
L
L
Beynon
R J
RJ
D000375:Aging / Q000502:physiology; D000818:Animals; D030161:Avian Proteins / Q000032:analysis* / Q000378:metabolism*; D001715:Bird Diseases / Q000175:diagnosis / Q000378:metabolism; D001717:Birds / Q000378:metabolism*; D005504:Food Analysis; D020543:Proteome / Q000378:metabolism; D040901:Proteomics / Q000379:methods*
D030161:Avian Proteins; D020543:Proteome