Glycerol affects the acyl moieties of teicoplanin components produced by Actinoplanes teichomyceticus MSl2210.
Teicoplanin, a glycopeptide antibiotic, is composed of five main components, denoted T-A2-1 to T-A2-5. We investigated the use of glycerol as a carbon source affecting the teicoplanin components and its acyl moieties. As a result, we show the change of teicoplanin components, as well as an increase of total teicoplanin yields, caused by the addition of glycerol to the production medium. Analysis of the total cell lipids upon the addition of glycerol also showed a corresponding change in the proportion of teicoplanin, suggesting that glycerol strongly affects a change of teicoplanin branched acyl moieties.
Department of Food Science and Biotechnology, Kyungnam University, Masan, Republic of Korea.
Hae-Ryong
HR
Park
Jae-Chan
JC
Lee
Ji-Hwan
JH
Hwang
Dong-Jin
DJ
Park
Chang-Jin
CJ
Kim
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry*; D003470:Culture Media / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism*; D008848:Micromonosporaceae / Q000737:chemistry / Q000378:metabolism*; D017334:Teicoplanin / Q000096:biosynthesis* / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D017334:Teicoplanin; D005990:Glycerol