[Monte-Carlo-Model for the aerosol bolus dispersion in the human lung--part 2: model predictions for the diseased lung].
After a mathematical extension of the existing model for the theoretical description of the aerosol bolus dispersion, the behavior of particle pulses in diseased lung structures was simulated. The geometry usedJbr healthy lungs was modified in two aspects: First, a modelling of possible airway obstructions, which usually occur in patients with chronic bronchitis, chronic asthma or cystic fibrosis, was carried out and, second, a theoretical approximation of the emphysema, being observed in lungs of smokers, but also as an accompanying phenomenon in obstructive diseases, was established. According to the modified model, in lungs with airway obstructions the exhaled bolus exhibited a decreased dispersion with respect to healthy subjects, whereas in emphysematous lungs the respective half-width of the peak was increased. Standard deviation and skewness of the bolus were similarly influenced by the modified lung architecture. A combination of airway obstruction and emphysema caused an extensive compensation of individual dispersion effects, complicating a secure distinction from the healthy lung. According to the model, a special diagnostic value may be assigned to the bolus deposition, showing significant deviations from the normal case for all simulated diseases.
Fachbereich für Molekulare Biologie, Abteilung für Physik und Biophysik, Universität Salzburg, Osterreich. Robert.Sturm@sbg.ac.at
Robert
R
Sturm
Elzbieta
E
Pawłak
Werner
W
Hofmann
D000280:Administration, Inhalation; D000336:Aerosols; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000033:anatomy & histology*; D008171:Lung Diseases / Q000188:drug therapy*; D008954:Models, Biological; D009010:Monte Carlo Method; D011650:Pulmonary Alveoli / Q000033:anatomy & histology / Q000473:pathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000473:pathology
D000336:Aerosols