First total synthesis of a pentasaccharide repeating unit of the O-antigen of Hafnia alvei PCM 1529.
A pentasaccharide repeating unit of the O-antigen of Hafnia alvei has been synthesized in a concise manner. High yielding glycosylation steps and minimum number of protecting group manipulation steps are the key features of this synthesis. A two-step, one-pot phase transfer oxidation protocol has been applied for the preparation of D-galacturonic acid.
Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India.
Chinmoy
C
Mukherjee
Anup Kumar
AK
Misra
D001428:Bacterial Vaccines / Q000138:chemical synthesis; D002240:Carbohydrate Sequence; D020611:Hafnia alvei / Q000737:chemistry*; D008969:Molecular Sequence Data; D019081:O Antigens / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D011135:Polysaccharides, Bacterial / Q000737:chemistry*
D001428:Bacterial Vaccines; D019081:O Antigens; D009844:Oligosaccharides; D011135:Polysaccharides, Bacterial