Presence of talc in pelvic lymph nodes of a woman with ovarian cancer and long-term genital exposure to cosmetic talc.
BACKGROUND
Although epidemiologic studies suggest talc use may increase ovarian cancer risk, there is no proof that talc used externally reaches the pelvis.


METHODS
A 68-year-old woman with stage III ovarian papillary serous carcinoma revealed she had used talc daily for 30 years to powder her genital area. Examination of her pelvic lymph nodes under polarized light microscopy showed diffuse areas of birefringence compatible with talc, confirmed by scanning electron microscopy and X-ray spectroscopy.


CONCLUSIONS
This description of talc in pelvic lymph nodes of a woman with ovarian cancer and decades of exposure to talc may prompt new studies and offer new insights into the biologic basis for the consistent, but debated, association between talc use and ovarian cancer.
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. dcramer@partners.org
Daniel W
DW
Cramer
William R
WR
Welch
Ross S
RS
Berkowitz
John J
JJ
Godleski
D000368:Aged; D002291:Carcinoma, Papillary / Q000209:etiology* / Q000473:pathology; D004577:Electron Probe Microanalysis; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000737:chemistry* / Q000473:pathology / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D008859:Microscopy, Polarization; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000473:pathology; D012307:Risk Factors; D013627:Talc / Q000009:adverse effects* / Q000032:analysis
D013627:Talc