Synthesis of the C1-C12 fragment of the tedanolides. Aldol-non-aldol aldol approach.
The combination of highly stereoselective non-aldol aldol and aldol processes allows the preparation of the completely protected C1-C12 fragment 2 of the novel macrocyclic cytotoxic agent tedanolide 1.
Jung
Michael E
ME
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, USA. jung@chem.ucla.edu
Yoo
Dongwon
D
D000447:Aldehydes / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D018942:Macrolides; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; D000970:Antineoplastic Agents; D007783:Lactones; D018942:Macrolides; C116609:3-hydroxybutanal; C119775:tedanolide