Neuroprotection during cardiac surgery.
Cerebral injury following cardiac surgery continues to be a significant source of morbidity and mortality after cardiac surgery. A spectrum of injuries ranging from subtle neurocognitive dysfunction to fatal strokes are caused by a complex series of multifactorial mechanisms. Protecting the brain from these injuries has focused on intervening on each of the various etiologic factors. Although numerous studies have focused on a pharmacologic solution, more success has been found with nonpharmacologic strategies, including optimal temperature management and reducing emboli generation.
Grocott
Hilary P
HP
Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA.
Yoshitani
Kenji
K
D050197:Atherosclerosis / Q000150:complications / Q000628:therapy; D001831:Body Temperature / Q000502:physiology; D003072:Cognition Disorders / Q000517:prevention & control*; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology / Q000628:therapy; D007036:Hypothermia, Induced; D015994:Incidence; D020766:Intracranial Embolism / Q000209:etiology / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D011673:Pulsatile Flow / Q000502:physiology; D020521:Stroke / Q000517:prevention & control*; D013997:Time Factors
D018696:Neuroprotective Agents