Mechanical, setting, and biological properties of bone cements containing micron-sized titania particles.
In this study, polymethylmethacrylate-based composite cements containing 40-55.6 wt% micron-sized titania (titanium oxide) particles were developed, and their mechanical, setting, and biological properties evaluated. Three types of composite cement containing 40, 50, and 55.6 wt% silanized titania were designated ST2-40c, ST2-50c, and ST2-56c, respectively. In animal experiments, ST2-50c and ST2-56c were implanted into rat tibiae and solidified in situ. An affinity index was used to evaluate osteoconductivity. Compressive and bending strength of ST2-56c was 147.7+/-3.2 and 69.3+/-7.4; those of the other cements exceeded 100 MPa and 50 MPa, respectively. The affinity indices of ST2-56c were 42.1+/-12.9 at six weeks and 53.4+/-16.6 at 12 weeks, and were significantly higher than for ST2-50c and a commercial PMMA bone cement within 12 weeks. Our data indicate that bone cement containing micron-sized titania particles can be applied to prosthesis fixation as well as vertebroplasty, and ST2-56c is a good candidate cement.
Goto
Koji
K
Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Kawahara-cho 54, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. k.g.bau@kuhp.kyoto-u.ac.jp
Hashimoto
Masami
M
Takadama
Hiroaki
H
Tamura
Jiro
J
Fujibayashi
Shunsuke
S
Kawanabe
Keiichi
K
Kokubo
Tadashi
T
Nakamura
Takashi
T
D000818:Animals; D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects; D019245:Compressive Strength; D004548:Elasticity; D008297:Male; D008422:Materials Testing; D008863:Microspheres; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D013696:Temperature; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology
D001843:Bone Cements; C009495:titanium dioxide; D014025:Titanium