Magnetic controllable biorecognition process of doxorubicin detected by electrochemical contact angle measurement.
Fe3O4 nanoparticles are the most commonly used magnetic materials with promising applications in biomedical and biochemical engineering. In this study, a novel application of the tetraheptylammonium capped Fe3O4 nanoparticles in controllable biorecognition process of anticancer drug doxorubicin through combination with external static magnetic field has been demonstrated. Our AFM and electrochemical studies illustrate that the presence of the tetraheptylammonium capped Fe3O4 nanoparticles could promote the binding behavior of doxorubicin to DNA. And the results of the electrochemical contact angle measurements indicate that the controllable biomolecular recognition of doxorubicin could be readily achieved by combining these functionalized Fe3O4 nanoparticles with changing the positions of external magnetic field.
State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing 210096, PR China.
Jian
J
Zhou
Renyun
R
Zhang
Xiaomao
X
Li
Sebastian
S
Gutmann
Gang
G
Lv
Xuemei
X
Wang
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D001698:Biomedical Engineering; D002244:Carbon / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D005290:Ferric Compounds / Q000737:chemistry*; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D053761:Nanocomposites / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry
D000903:Antibiotics, Antineoplastic; D005290:Ferric Compounds; D000644:Quaternary Ammonium Compounds; C000499:ferric oxide; D002244:Carbon; D004317:Doxorubicin; D004247:DNA