[Genetic characteristics of six Chinese Han keloid pedigrees].
OBJECTIVE
To study the genetic characteristics of keloid in 6 Chinese Han pedigrees.


METHODS
The clinical data of 6 unrelated Chinese Han keloid pedigrees were collected, and their pedigree charts were constructed and the inheritance patterns analyzed.


RESULTS
Keloid onset in the patients of these pedigrees mainly occurred during adolescence, with equal chance for involvement in male and female subjects. The affected individual could be heterozygous, and a child with one affected parent had a 50% chance of being affected. The trait of keloid was transmitted consecutively in 3 pedigrees, showing complete penetrance, but in the other 3 pedigrees, it was transmitted intermittently, suggesting incomplete penetrance. The clinical phenotype of keloid presented a variable expression among the affected individuals in these pedigrees.


CONCLUSIONS
The inheritance pattern observed in these Chinese Han keloid pedigrees is consistent with an autosomal dominant inheritance with incomplete penetrance, variable expressivity and delayed dominance.
Department of Plastic Surgery, Affiliated Stomatological Hospital of Fujian Medical University, Fuzhou 350002, China. cy_chen03@126.com
Yang
Y
Chen
Jian-hua
JH
Gao
Xiao-jun
XJ
Liu
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D002648:Child; D005260:Female; D006801:Humans; D007627:Keloid / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D055815:Young Adult