Multifunctional nanorods for biomedical applications.
Multifunctional nanorods have shown significant potential in a wide range of biomedical applications. Nanorods can be synthesized by a top down or bottom-up approach. The bottom-up approach commonly utilizes a template deposition methodology. A variety of metal segments can easily be incorporated into the nanorods. This permits high degrees of chemical and dimensional control. High aspect-ratio nanorods have a large surface area for functionalization. By varying the metal segments in the nanorods, spatial control over the binding of functional biomolecules that correspond with the unique surface chemistry of the metal segment can be achieved. Functionalized multicomponent nanorods are utilized in applications ranging from multiplexing, protein sensing, glucose sensing, imaging, biomolecule-associated nanocircuits, gene delivery and vaccinations.
Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, Iowa 52242, USA.
Megan E
ME
Pearce
Jessica B
JB
Melanko
Aliasger K
AK
Salem
D000818:Animals; D020811:Biomedical Technology; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis; D003952:Diagnostic Imaging / Q000379:methods; D018014:Gene Transfer Techniques; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D043942:Nanotubes / Q000737:chemistry*; D011506:Proteins / Q000032:analysis; D013678:Technology, Pharmaceutical / Q000379:methods*
D001786:Blood Glucose; D011506:Proteins