Notch: filling a hole in T helper 2 cell differentiation.
In this issue of Immunity, Amsen et al. (2007) and Fang et al. (2007) propose a direct role for Notch signaling in the expression of GATA-3 transcription factor and T helper 2 cell differentiation.
Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Suehiro-cho 1-7-22, Tsurumi, Yokohama, Kanagawa 230-0045, Japan. raysolfc@rcai.riken.jp
Masato
M
Kubo
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D051880:Receptors, Notch / Q000502:physiology*; D018418:Th2 Cells / Q000166:cytology* / Q000378:metabolism*
D051880:Receptors, Notch