[Exocytotic release of signaling molecules from astrocytes].
Astrocyte secrete many kinds of bioactive substances including growth factors and cytokines. Recent accumulating evidences showed that astrocyte also release neurotransmitters and modulators such as glutamate, ATP and D-serine. At least, some part of these releases are mediated by exocytosis in SNARE- and Ca2+-dependent manners. These functions may play important roles in the regulation of neuronal and brain functions.
Department of Biochemistry, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan.
Masami
M
Takahashi
Makoto
M
Itakura
Saori
S
Yamamori
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001921:Brain / Q000502:physiology; D002118:Calcium / Q000502:physiology; D005089:Exocytosis / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D050600:SNARE Proteins / Q000502:physiology; D012694:Serine / Q000378:metabolism
D047908:Intracellular Signaling Peptides and Proteins; D018377:Neurotransmitter Agents; D050600:SNARE Proteins; D018698:Glutamic Acid; D012694:Serine; D000255:Adenosine Triphosphate; D002118:Calcium