Concomitant secretion of glucocorticoid, androgens, and mineralocorticoid by an adrenocortical carcinoma: case report and review of literature.
OBJECTIVE
To present a case of concomitant secretion of cortisol, androgens, and 11-deoxycorticosterone (DOC) by an adrenocortical carcinoma and review the literature in an attempt to identify similar cases.


METHODS
The patient's medical history, physical examination, laboratory data, computed tomographic scan, and histopathologic results were analyzed and summarized in a case report, and an extensive review of the literature was performed.


RESULTS
Endocrinologic data showed excess cortisol production, substantially elevated testosterone and androstenedione levels, and profoundly increased DOC in the setting of suppressed aldosterone. An abdominal computed tomographic scan showed a left adrenal tumor. A left adrenalectomy was performed, and the histopathologic diagnosis was stage II adrenocortical carcinoma. The review of the pertinent literature revealed the absence of any identical cases in the past.


CONCLUSIONS
Our patient presented with a rare case of cosecretion of cortisol, testosterone, androstenedione, and DOC by an adrenocortical carcinoma, resulting in a clinical picture consistent with Cushing's syndrome, hyperandrogenism, and primary hypermineralocorticoidism. We recommend the routine performance of a DOC assay in the setting of mineralocorticoid excess in association with low plasma aldosterone levels.
Messer
Caroline K
CK
Department of Internal Medicine, Mount Sinai School of Medicine, New York 10029, USA.
Kirschenbaum
Alexander
A
New
Maria I
MI
Unger
Pamela
P
Gabrilove
J Lester
JL
Levine
Alice C
AC
D000306:Adrenal Cortex Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D018268:Adrenocortical Carcinoma / Q000000981:diagnostic imaging / Q000378:metabolism*; D000328:Adult; D000735:Androstenedione / Q000097:blood; D003900:Desoxycorticosterone / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008901:Mineralocorticoids / Q000097:blood*; D013739:Testosterone / Q000097:blood*; D014057:Tomography, X-Ray Computed
D008901:Mineralocorticoids; D013739:Testosterone; D000735:Androstenedione; D003900:Desoxycorticosterone; D006854:Hydrocortisone