Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli.
In defined, isogenic strains, at least three mutations, two of which must be in gyrA, were required to exceed the CLSI breakpoint for fluoroquinolone resistance. Strains with double mutations in both gyrA and parC had even higher MICs of fluoroquinolones than strains with totals of three mutations.
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Mail-stop BCM-280, Houston, TX 77030-3411, USA.
Sonia K
SK
Morgan-Linnell
Lynn
L
Zechiedrich
D026942:DNA Topoisomerases / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics*; D024841:Fluoroquinolones / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009154:Mutation
D024841:Fluoroquinolones; D026942:DNA Topoisomerases