Low-carbohydrate nutrition and metabolism.
The persistence of an epidemic of obesity and type 2 diabetes suggests that new nutritional strategies are needed if the epidemic is to be overcome. A promising nutritional approach suggested by this thematic review is carbohydrate restriction. Recent studies show that, under conditions of carbohydrate restriction, fuel sources shift from glucose and fatty acids to fatty acids and ketones, and that ad libitum-fed carbohydrate-restricted diets lead to appetite reduction, weight loss, and improvement in surrogate markers of cardiovascular disease.
Westman
Eric C
EC
Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA. ewestman@duke.edu
Feinman
Richard D
RD
Mavropoulos
John C
JC
Vernon
Mary C
MC
Volek
Jeff S
JS
Wortman
James A
JA
Yancy
William S
WS
Phinney
Stephen D
SD
D002318:Cardiovascular Diseases / Q000453:epidemiology; D050528:Diet, Carbohydrate-Restricted / Q000009:adverse effects; D004040:Dietary Carbohydrates / Q000378:metabolism*; D015444:Exercise; D006801:Humans; D007657:Ketone Bodies / Q000378:metabolism; D009752:Nutritional Status; D012307:Risk Factors; D015431:Weight Loss
D004040:Dietary Carbohydrates; D007657:Ketone Bodies