[Synthesis and biological properties of 6-oxa-D-homo-8alpha analogues of steroid estrogens].
Modifications of 6-oxa-D-homo-8alpha-analogues of steroid estrogens were found to lead to a complete loss of the uterotropic and hypertriglyceridemic activities. These compounds may be promising for the design on their basis of inhibitors of the steroid hormone metabolism and transporters of other compounds to the estrogen target organs.
Shavva
A G
AG
Morozkina
S N
SN
Ishchenko
I V
IV
Eliseev
I I
II
Selivanov
S I
SI
Abusalimov
Sh N
ShN
Selivanov
S S
SS
Kameneva
I Iu
IIu
Eshchenko
N D
ND
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004967:Estrogens / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D011980:Receptors, Progesterone / Q000096:biosynthesis; D013237:Stereoisomerism; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013429:Sulfatases / Q000037:antagonists & inhibitors; D014280:Triglycerides / Q000097:blood; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism
D000924:Anticholesteremic Agents; D004967:Estrogens; D011980:Receptors, Progesterone; D013256:Steroids; D014280:Triglycerides; D002784:Cholesterol; D013429:Sulfatases; C020121:estrone sulfatase