Hairy cell leukemia.
Hairy cell leukemia (HCL) is a chronic B-cell lymphoproliferative disorder characterized by pancytopenia and variable infiltration of the reticuloendothelial system with "hairy" lymphocytes. HCL is more common in men than women and has a median age of diagnosis of 52 yr. Typically, patients with HCL respond well to purine analog-based therapy. The purpose of this review will be to establish the current status of HCL with respect to its pathophysiology, diagnosis, management, and future directions.
Swords
Ronan
R
Department of Haematology, University College Hospital Galway, Galway, Ireland.
Giles
Francis
F
D006801:Humans; D007943:Leukemia, Hairy Cell / Q000175:diagnosis / Q000628:therapy