Revealing the enigmas of implantation: what is the true impact of ovarian hyperstimulation?
It is agreed that ovarian stimulation results in histopathologic changes and variations in gene expression when compared to natural cycles. However, the enigma is still present: What is the true impact of variable degrees of embryo-endometrium developmental asynchrony in the presence of high clinical embryo implantation rates in IVF? It is postulated that the temporal characterization of gene expression and protein profiles of isolated endometrial compartments might unveil patterns that are critical for the establishment of the window of implantation.
The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA. OehninSC@EVMS.edu
Sergio
S
Oehninger
D015925:Cryopreservation; D046149:Embryo Culture Techniques; D010064:Embryo Implantation / Q000235:genetics; D004624:Embryo Transfer; D004717:Endometrium / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007247:Infertility, Female / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D008597:Menstrual Cycle / Q000235:genetics; D018587:Oocyte Donation; D054315:Oocyte Retrieval; D010062:Ovulation Induction / Q000009:adverse effects*; D011247:Pregnancy; D018873:Pregnancy Rate; D012107:Research Design; D013997:Time Factors; D014021:Tissue Preservation / Q000379:methods; D016896:Treatment Outcome