Acute T lymphoid and megakaryoblastic bi-lineal leukemia in a child.
A 1 1/2-year-old boy presented with fever, anemia, petechial rash and hepatosplenomegaly. Bone marrow examination showed two morphologically distinct blasts (small and large) which were confirmed on immunophenotyping to be of T-lymphoid and megakaryocytic lineages respectively. Patient was refractory to therapy. This is a rare combination of bi-lineal leukemia in a child.
Srinivas
Upendra
U
Departments of Hematology and Medical Oncology, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110 029, India.
Saxena
Renu
R
Bakhshi
Sameer
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017809:Fatal Outcome; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D007223:Infant; D007947:Leukemia, Megakaryoblastic, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D013163:Splenomegaly / Q000209:etiology; D013601:T-Lymphocytes / Q000473:pathology