Dissecting the mammalian synaptonemal complex using targeted mutations.
In many organisms completion of the first meiotic cell division depends on the correct assembly and disassembly of the synaptonemal complex (SC). This is a structure discovered a little over 50 years ago, which is formed by the close association of axes of homologous sister chromatid pairs. Its structure varies between organisms, although it retains a common tripartite organization in species as evolutionarily distant as budding yeast and humans. In mammals it is essential for crossover formation and completion of meiosis. Components of the mammalian SC have been identified only in the last 15 years, and mouse genetic approaches have started revealing the importance for this structure only in the past 5 years. Here we discuss the progress that has been made in the field of the mammalian SC and what approaches could be considered for its further study.
Division of Developmental Genetics and Stem Cell Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.
Yael
Y
Costa
Howard J
HJ
Cooke
D000818:Animals; D004268:DNA-Binding Proteins; D005260:Female; D006801:Humans; D008297:Male; D008540:Meiosis / Q000235:genetics / Q000502:physiology; D051379:Mice; D008957:Models, Genetic; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D013573:Synaptonemal Complex / Q000737:chemistry / Q000235:genetics* / Q000502:physiology
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C504910:SYCE1 protein, mouse; C504911:SYCE2 protein, mouse; C489754:Sycp1 protein, mouse