Acetylcholinesterase inhibitory effect of lignans isolated from Schizandra chinensis.
The hexane extract of the fruit of Schizandra chinensis (Schisandraceae) was found to show significant inhibition of the activity of acetylcholinesterase enzyme (AChE). In further studies, fourteen lignans were isolated, and evaluated for their inhibitory effect on AChE. The compounds having both aromatic methylenedioxy and hydroxyl groups on their cyclooctadiene ring, such as gomisin C (6), gomisin G (7), gomisin D (8), schisandrol B (11) and gomisin A (13), entirely inhibited AChE in dose dependent manners, with IC50 values of 6.71 +/- 0.53, 6.55 +/- 0.31, 7.84 +/- 0.62, 12.57 +/- 1.07 and 13.28 +/- 1.68 microM, respectively. These results indicate that the lignans could potentially be a potent class of AChE inhibitors.
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Tran Manh
TM
Hung
MinKyun
M
Na
Byung Sun
BS
Min
Tran Minh
TM
Ngoc
IkSoo
I
Lee
XinFeng
X
Zhang
KiHwan
K
Bae
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D006586:Hexanes; D066298:In Vitro Techniques; D007700:Kinetics; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D032141:Schisandra / Q000737:chemistry*; D012997:Solvents
D002800:Cholinesterase Inhibitors; D006586:Hexanes; D017705:Lignans; D012997:Solvents