Type I lepra reaction presenting as immune reconstitution inflammatory syndrome.
Immune reconstitution inflammatory syndrome (IRIS) is an unusual inflammatory reaction due to infectious and non-infectious causes occurring in human Immunodeficiency virus (HIV)-infected patients. IRIS occurs after the initiation of antiretroviral therapy. There are no reports of type I lepra reaction due to IRIS in published literature from India. We report two cases of HIV-infected males who presented with borderline tuberculoid leprosy in type 1 reaction after the initiation of highly active antiretroviral treatment (HAART). Case 1 presented with multiple, tender, erythematous and hypoesthetic plaques on the trunk and extremities after 3 months of antiretroviral therapy. In case 2, type I lepra reaction was observed 2 months after the initiation of HAART.
Department of Dermatology, Seth G. S. Medical College and KEM Hospital, Mumbai, India. drvidyakharkar@gmail.com
Vidya
V
Kharkar
Urmila H
UH
Bhor
Sunanda
S
Mahajan
Uday
U
Khopkar
D017088:AIDS-Related Opportunistic Infections / Q000139:chemically induced*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D007917:Leprostatic Agents / Q000627:therapeutic use; D015439:Leprosy, Borderline / Q000139:chemically induced* / Q000175:diagnosis; D015441:Leprosy, Tuberculoid / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D012867:Skin / Q000473:pathology; D013577:Syndrome
D007917:Leprostatic Agents