[The types of cell death].
Apoptosis was long considered the major mechanism of programmed cell death. However, results obtained during the last years have proved that chemotherapeuticals as well as a number of other factors may induce modes of cell death different from apoptosis. The identified mechanisms include mitotic catastrophe, autophagy, necrosis and, in the context of cancer therapy, senescence. The purpose of the following review is a general description of these processes.
Katedra i Zakład Histologii i Embriologii Collegium Medicum im. L. Rydygiera w Bydgoszczy UMK w Toruniu. a_stepien@cm.umk.pl
Aleksandra
A
Stepień
Magdalena
M
Izdebska
Alina
A
Grzanka
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001343:Autophagy / Q000187:drug effects / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D002470:Cell Survival / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D008938:Mitosis / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D009336:Necrosis / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D008941:Spindle Apparatus / Q000187:drug effects / Q000378:metabolism; D019098:Telomerase / Q000378:metabolism
D000970:Antineoplastic Agents; D019098:Telomerase; D020169:Caspases