In vitro PAI-1 inhibitory activity of oxalamide derivatives.
A number of oxalamide derivatives have been synthesized and evaluated for PAI-1 inhibitory activity. In vitro PAI-1 inhibitory activities of oxalamide derivatives are evaluated by chromogenic assay. Few compounds have shown significant PAI-1 inhibitory activity.
Jain
Mukul R
MR
Zydus Research Centre, Sarkhej-Bavla NH No. 8A, Moraiya, Ahmedabad-382210, Gujarat, India. mukul.jain@zyduscadila.com
Shetty
Shankar
S
Chakrabarti
Ganes
G
Pandya
Vrajesh
V
Sharma
Ajay
A
Parmar
Bhavesh
B
Srivastava
Soma
S
Raviya
Mehul
M
Soni
Hitesh
H
Patel
Pankaj R
PR
D000577:Amides / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D010072:Oxamic Acid / Q000737:chemistry / Q000494:pharmacology*; D017395:Plasminogen Activator Inhibitor 1 / Q000737:chemistry* / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000737:chemistry* / Q000378:metabolism*; D010959:Tissue Plasminogen Activator / Q000378:metabolism
D000577:Amides; D017395:Plasminogen Activator Inhibitor 1; D015842:Serine Proteinase Inhibitors; D010959:Tissue Plasminogen Activator; D010072:Oxamic Acid