"Hands-on" regulation of B cell development by the transcription factor Pax5.
The transcription factor Pax5 is a critical regulator of B lymphocyte commitment and identity. In this issue of Immunity, Schebesta et al. (2007) demonstrate how Pax5 activates 170 different genes involved in B cell signaling, adhesion, migration, and maturation.
Integrated Department of Immunology, K516B, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. hagmanj@njc.org
James
J
Hagman
Kara
K
Lukin
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism*; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D051757:PAX5 Transcription Factor / Q000502:physiology*
D051757:PAX5 Transcription Factor; C497282:Pax5 protein, mouse