Association between components of the metabolic syndrome and serum levels of C-reactive protein in Japanese workingmen.
Middle-aged workingmen (N=984) with no present medical treatment were enrolled to determine whether there is an association between the metabolic syndrome (MetS) and serum levels of C-reactive protein. MetS was defined as follows: waist circumference > or = 85 cm as a necessary criterion; in addition, two or more of the following criteria were required: serum triglycerides > or = 150 mg/dL and/or highdensity lipoprotein cholesterol <40 mg/dL; systolic blood pressure > or = 130 mm Hg and/or diastolic blood pressure > or = 85 mm Hg; fasting blood glucose > or = 110 mg/dL. Three groups were identified by the components of MetS: a reference group of subjects with a waist circumference <85 cm; group A, with a waist circumference > or = 85 cm with no or one additional MetS criterion; and group B, subjects satisfying the criteria for a diagnosis of MetS. Logistic regression analysis revealed that the components of MetS contributed significantly to serum levels of C-reactive protein. The odds ratios were 2.5 (group A) and 4.0 (group B), when 3 mg/L was adopted as the cutoff value of C-reactive protein.
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan. kawada@nms.ac.jp
Tomoyuki
T
Kawada
Toshiaki
T
Otsuka
Masao
M
Katsumata
Hiroko
H
Suzuki
D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D049628:Body Size; D002097:C-Reactive Protein / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D004651:Employment; D006306:Health Surveys; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000453:epidemiology; D006949:Hyperlipidemias / Q000097:blood* / Q000453:epidemiology; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D016017:Odds Ratio; D018570:Risk Assessment; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides; D002097:C-Reactive Protein