A method of producing carcinoma in upper aerodigestive tree and esophagus of the Syrian golden hamster using wounding and instillation of N-methylnitrosourea.
Details of a method for producing carcinoma of the aerodigestive tree of the Syrian golden hamster and the use of this model to evaluate putative agents for chemoprevention of these carcinomas are described. The method produces a majority of squamous carcinomas of the trachea and glottis that follow squamous metaplasia of respiratory epithelium. In addition, seen are adenocarcinomas arising in glands of the respiratory tree. Squamous carcinomas of the digestive epithelium arise in primary squamous epithelium. These tumors of digestive epithelium have a growth pattern that differs from that of the respiratory epithelium in that they grow and invade without filling the epithelial layer with tumor cells.
Estensen
Richard D
RD
Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota USA. esten001@umn.edu
Anderson
W Robert
WR
Galbraith
Arthur R
AR
Hartle
Donna E
DE
Jordan
Margaret M
MM
Ondrey
Frank G
FG
Wattenberg
Lee W
LW
D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D002273:Carcinogens; D002277:Carcinoma / Q000209:etiology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology; D018890:Chemoprevention; D006224:Cricetinae; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D004938:Esophageal Neoplasms / Q000209:etiology / Q000473:pathology; D005931:Glottis / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000209:etiology / Q000473:pathology; D008647:Mesocricetus; D008679:Metaplasia; D008770:Methylnitrosourea / Q000009:adverse effects*; D009092:Mucous Membrane / Q000473:pathology; D010610:Pharyngeal Neoplasms / Q000209:etiology / Q000473:pathology; D020545:Respiratory Mucosa / Q000473:pathology; D014132:Trachea / Q000187:drug effects / Q000293:injuries*; D014134:Tracheal Neoplasms / Q000209:etiology* / Q000473:pathology
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D008770:Methylnitrosourea