Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage.
Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA. lamarca@bcm.edu
Heather L
HL
LaMarca
Jeffrey M
JM
Rosen
D066258:Amphiregulin; D001940:Breast / Q000254:growth & development* / Q000473:pathology; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology; D066255:EGF Family of Proteins; D004967:Estrogens / Q000494:pharmacology*; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*
C587848:AREG protein, human; D066258:Amphiregulin; D066255:EGF Family of Proteins; D004967:Estrogens; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins