[Modulatory effects of peri-interneuronal glial cells on neuronal activities].
Recently, it has been demonstrated that glial cells express a variety of ion channels and neurotransmitter receptors and can modulate the neuronal activities. We focused on interneuron/peri-interneuronal glial cell pairs in the hippocampus to investigate the direct interactions between these cells. The periinterneuronal astrocytes suppressed the excitatory postsynaptic currents in an adjacent interneuron through the presynaptic mechanism. Moreover, peri-interneuronal astrocytes activation modulated the interneuronal firing pattern with time dependent manner. These results indicate that peri-interneuronal astrocytes play important roles in the modulation of hippocampal excitability.
Department of Neurophysiology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990 9585, Japan.
Yoshihiko
Y
Yamazaki
Hiroshi
H
Kato
D000818:Animals; D001253:Astrocytes / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D009435:Synaptic Transmission / Q000502:physiology