Spinal cord ischemia after endovascular repair of the descending thoracic aorta in a sheep model.
OBJECTIVE
Spinal cord ischemia remains a devastating complication after thoracic aortic surgery. The aim of this study was to investigate the pathophysiology of spinal cord ischemia after thoracic aortic endografting and the role of intercostal artery blood supply for the spinal cord in a standardized animal model.


METHODS
Female merino sheep were randomized to either I, open thoracotomy with cross-clamping of the descending aorta for 50 min (n=7), II, endograft implantation (TAG, WL Gore & Ass.), (n=6) or III open thoracotomy with clipping of all intercostal arteries (n=5) . CT-angiography was used to assess completion of surgical protocol and assess the fate of intercostal arteries. Tarloy score was used for daily neurological examination for up to 7 days post-operatively. Histological cross sections of the lumbar, thoracic and cervical spinal cords were scored for ischemic damage after stained with Hematoxylin-Eosin, Klüver-Barrrera and antibodies. Exact Kruskall-Wallis-Test was used for statistical assessment (p<0.05).


RESULTS
Incidence of paraplegia was 100% in group I and 0% in group II (p=0.0004). When compared to the endovascular group, there was a higher rate of histological changes associated with spinal cord ischemia in the animals of the control group (p=0.0096). Group III animals showed no permanent neurological deficit and only 20% infarction rate (p=0.0318 compared to group I).


CONCLUSIONS
In sheep, incidence of histological and clinical ischemic injury of the spinal cord following endografting was very low. Complete thoracic aortic stent-grafting was feasible without permanent neurologic deficit. Following endovascular coverage or clipping of their origins, there is retrograde filling of the intercostal arteries which remain patent.
Böckler
D
D
Department of Vascular and Endovascular Surgery, Biomedical Research Institution, Ruprecht-Karls University, Heidelberg, Germany. dittmar_boeckler@med.uni-heidelberg.de
Kotelis
D
D
Kohlhof
P
P
von Tengg-Kobligk
H
H
Mansmann
U
U
Zink
W
W
Hörner
C
C
Ortlepp
I
I
Habel
A
A
Kauczor
H-U
HU
Graf
B
B
Allenberg
J-R
JR
D000818:Animals; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000601:surgery*; D001158:Arteries / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects*; D005260:Female; D007150:Immunohistochemistry; D007238:Infarction / Q000209:etiology; D023421:Models, Animal; D009460:Neurologic Examination; D010264:Paraplegia / Q000209:etiology; D011897:Random Allocation; D012756:Sheep; D013116:Spinal Cord / Q000098:blood supply / Q000473:pathology; D020760:Spinal Cord Ischemia / Q000209:etiology*; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed