Adipsic hypernatremia in a dog with antithyroid antibodies in cerebrospinal fluid and serum.
A 4-year-old, male Labrador retriever, weighing 27 kg, presented with abrupt clinical signs including mental retardation, circling and head pressing. The dog never ingested water by choice. An adipsia of the dog was persisted and developed to hypernatremia with artifactual hyperchloremia. Serial endocrine results and image findings were suggestive of a hypothyroidism. The dog revealed the presence of antithyroid antibodies in the cerebrospinal fluid and serum. With the administration of levothyroxine sodium, his neurologic signs were alleviated within the first week of treatment and adipsia was also resolved.
Kang
Ji-Houn
JH
Veterinary Medical Center, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361-763, USA.
Chang
Dongwoo
D
Lee
Young Won
YW
Na
Ki-Jeong
KJ
Yang
Mhan-Pyo
MP
D000818:Animals; D001323:Autoantibodies / Q000097:blood* / Q000134:cerebrospinal fluid*; D004283:Dog Diseases / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000276:immunology; D004285:Dogs; D006955:Hypernatremia / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000662:veterinary*; D007037:Hypothyroidism / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D013894:Thirst; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000276:immunology*; D013974:Thyroxine / Q000627:therapeutic use
D001323:Autoantibodies; D013974:Thyroxine