Effect of 17alpha-hydroxyprogesterone caproate before embryo transfer on the outcome of in vitro fertilization and embryo transfer: a randomized trial.
OBJECTIVE
To assess the effect of 17alpha-hydroxyprogesterone caproate (17-HPC) given before embryo transfer on the pregnancy outcome of IVF-embryo transfer (ET) cycles.


METHODS
Randomized controlled study.


METHODS
A university-based hospital IVF unit.


METHODS
One hundred twenty-five consecutive patients undergoing IVF-ET were randomly assigned into treatment and control groups.


METHODS
In the treatment group, 63 patients received 17-HPC (250 mg, i.m.), 1 day before ET. The control group consisted of 62 patients who did not receive any injections.


METHODS
Pregnancy and multiple-pregnancy rates.


RESULTS
The two groups were similar with respect to the age of patients, total dose of FSH, number of oocytes and embryos obtained, and number and quality of embryos transferred. There was no significant difference in the pregnancy rate (34.9% vs. 38.7%) or in the rate of multiple gestation (15.9% vs. 9.7%) between cases and controls, respectively.


CONCLUSIONS
The use of 17-HPC before ET does not appear to affect the outcome of IVF-ET.
Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: aa06@aub.edu.lb.
Antoine
A
Abu-Musa
Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon.
Ihab
I
Usta
Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon.
Anwar
A
Nassar
Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon.
Fatiha
F
Hajami
Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon.
Antoine
A
Hannoun
D000077713:17 alpha-Hydroxyprogesterone Caproate; D000328:Adult; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D006908:Hydroxyprogesterones / Q000494:pharmacology*; D008875:Middle Aged; D009130:Muscle, Smooth / Q000187:drug effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D011372:Progestins / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects
D006908:Hydroxyprogesterones; D011372:Progestins; D000077713:17 alpha-Hydroxyprogesterone Caproate