Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites.
Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.
Sparsø
Thomas
T
Steno Diabetes Center, Niels Steensens Vej 1, NLC2.13, DK-2820, Gentofte, Denmark. tspr@steno.dk
Hussain
Meena Shaheen
MS
Borch-Johnsen
Knut
K
Jørgensen
Torben
T
Madsbad
Sten
S
Hansen
Torben
T
Pedersen
Oluf
O
Andersen
Gitte
G
D001786:Blood Glucose / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002155:Calsequestrin; D016022:Case-Control Studies; D003718:Denmark / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D050171:Dyslipidemias / Q000453:epidemiology / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People
D001786:Blood Glucose; C503129:CASQ1 protein, human; D002135:Calcium-Binding Proteins; D002155:Calsequestrin; D007328:Insulin; D024101:Mitochondrial Proteins