Epigenetics and neural stem cell commitment.
Neural stem cell is presently the research hotspot in neuroscience. Recent progress indicates that epigenetic modulation is closely related to the self-renewal and differentiation of neural stem cell. Epigenetics refer to the study of mitotical/meiotical heritage changes in gene function that cannot be explained by changes in the DNA sequence. Major epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, genomic imprinting, and non-coding RNA. In this review, we focus on the new insights into the epigenetic mechanism for neural stem cells fate.
Tang
Hai-Liang
HL
Department of Neurosurgery, Fudan University, Huashan Hospital; National Key Laboratory for Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China.
Zhu
Jian-Hong
JH
D000818:Animals; D002454:Cell Differentiation; D042002:Chromatin Assembly and Disassembly; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D018392:Genomic Imprinting; D006801:Humans; D009474:Neurons / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*