Platelet hyperreactivity: predictive and intrinsic properties.
Platelet thrombi are central to the development of most vascular ischemic events. There is marked interindividual variation in platelet responsiveness, with some subjects displaying platelet hyperreactivity. An increasing number of reports indicate that there are laboratory measures of platelet function that predict clinical thrombotic events. Some, but not all, measures of platelet function are reproducible. Platelet hyperreactivity can be assessed with multiple stimuli in multiple assays and is more likely to be present in women and in subjects who have elevated fibrinogen levels.
Bray
Paul F
PF
Division of Hematology, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, PA 19107, USA. paul.bray@jefferson.edu
D002318:Cardiovascular Diseases / Q000175:diagnosis; D020022:Genetic Predisposition to Disease; D006801:Humans; D015539:Platelet Activation; D010979:Platelet Function Tests; D011237:Predictive Value of Tests; D013927:Thrombosis / Q000209:etiology