Humanizing infant milk formula to decrease postnatal HIV transmission.
There are currently no safe methods for feeding babies born from the 16 million HIV-infected women living in resource-constrained countries. Breast milk can transmit HIV, and formula feeding can lead to gastrointestinal illnesses owing to unsanitary conditions and the composition of milk formulations. There is therefore a need to ensure that breast milk substitutes provide optimal health outcomes. Given that the immune properties of several breast milk proteins are known, transgenic food crops could facilitate inexpensive and safe reconstitution of the beneficial breast milk proteome in infant formulae, while keeping the HIV virus at bay. At least seven breast milk immune proteins have already been produced in food crops, and dozens more proteins could potentially be produced if fortified formula proves effective in nursing newborns born to HIV-infected mothers.
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.
David R
DR
Blais
Illimar
I
Altosaar
D003906:Developing Countries; D005260:Female; D030841:Food, Genetically Modified; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000138:chemical synthesis*; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008895:Milk, Human / Q000201:enzymology / Q000276:immunology / Q000821:virology*; D030821:Plants, Genetically Modified / Q000276:immunology; D011994:Recombinant Proteins / Q000627:therapeutic use
D011994:Recombinant Proteins