Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications.
There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.
Calin
George A
GA
Department of Molecular Virology, Immunology and Medical Genetics, Colleges of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA.
Croce
Carlo M
CM
D000818:Animals; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D040641:Quantitative Trait Loci
D035683:MicroRNAs