[Characteristics of the immune system in workers of heavy industry with chronic bronchitis].
Chronic bronchitis is a disease at the base of it we see inflammation process, when under the influence of factors of environment the immune system changes. The author has studied the influence of adverse factors on the state of the immune system of workers of engineering plants with chronic bronchitis. 15 workers of engineering plants with chronic bronchitis have been observed. 8 workers with chronic bronchitis had unhealthy conditions of work (main group) and other 7 workers with chronic bronchitis had not had unhealthy conditions of work (control group). The author revealed workers of engineering plants with chronic bronchitis to have changes of the immune system characterized by the increase in immunoglobulin M by 0.64 +/- 0.3 g/l in comparison with the control group (P < 0.05) and the increase in immunoglobulin G by 5.02 +/- 1.65 g/l (P < 0.05). Immunoglobulin A has decreased by 1.60 +/- 0.45 g/l (p < 0.05) in comparison with the control group. Then, CD3+ was 66.0 +/- 2.9% in the main group and in the control group it was by 4.35 +/- 3.1% greater. It was seen decrease in the activity of T-suppressors of patients with chronic bronchitis who were exposed to unhealthy conditions of work. CD4+ and CD20+ were also different in the main and control groups. It is worthy to note that patients with chronic bronchitis working in unhealthy conditions (main group) had reduced activity of neutrophilic granulocytes while this activity is increased in the workers of the control group. So these data certify that changes in the immune system of workers of engineering plants with chronic bronchitis significantly correlate with the presence of unhealthy conditions in work.
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D015703:Antigens, CD / Q000276:immunology; D029481:Bronchitis, Chronic / Q000097:blood / Q000276:immunology*; D006801:Humans; D007107:Immune System; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008669:Metallurgy; D009784:Occupational Diseases / Q000097:blood / Q000276:immunology*; D016273:Occupational Exposure / Q000009:adverse effects*; D013491:Suppressor Factors, Immunologic / Q000097:blood
D015703:Antigens, CD; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D013491:Suppressor Factors, Immunologic