[Subclinical Cushing's disease: presentation of three cases and critical review].
Unlike subclinical Cushing's disease, adrenal subclinical Cushing's syndrome is widely recognized. It is defined as an autonomous cortisol hyperproduction of mild intensity not causing specific clinical signs, but detectable biochemically as derangements of the hypothalamic-pituitary-adrenal axis function. Although Cushing's disease accounts for the majority of hypercortisolism states, subclinical Cushing's disease has been rarely reported. Three cases of subclinical Cushing's disease due to pituitary corticotrophic macroadenomas, confirmed by immunohistochemistry, are presented in order to underscore its recognition by clinical endocrinologists and to emphasize a diagnostic evaluation of hypercortisolism in all cases of pituitary adenomas.
Silva
Bárbara C Carvalho
BC
Serviço de Endocrinologia, Santa Casa de Belo Horizonte, Belo Horizonte, MG.
Baruqui Júnior
Alfredo M
AM
Barbosa
Víctor Eurípedes
VE
Pena
Gil Patrus Mundim
GP
Campos
Marisa Helena de F
MH
Ramos
Adauto Versiani
AV
Dias
Eduardo Pimentel
EP
D000236:Adenoma / Q000150:complications* / Q000473:pathology; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003480:Cushing Syndrome / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications* / Q000473:pathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D013974:Thyroxine