Aromatase inhibitor therapy for uterine bleeding in a postmenopausal woman with leiomyomata.
Although most women with symptoms caused by uterine fibroids are in their 30s or 40s, these tumors can cause postmenopausal bleeding. An obese postmenopausal woman experienced persistent uterine bleeding. Evaluation revealed no evidence of neoplasia, and the patient preferred medical to surgical management. Use of the aromatase inhibitor anastrozole was associated with reduction in the size of her dominant fibroid, thinning of her endometrium, and cessation of bleeding. If future studies confirm the promising findings observed in this patient, use of aromatase inhibitors may prove useful in treating uterine bleeding associated with fibroids in postmenopausal women.
Kaunitz
Andrew M
AM
Department of Obstetrics and Gynecology, University of Forida College of Medicine-Jacksonville, FL 32209, USA. andrew.kaunitz@jax.ufl.edu
D000077384:Anastrozole; D047072:Aromatase Inhibitors / Q000008:administration & dosage*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D009570:Nitriles / Q000008:administration & dosage*; D017698:Postmenopause; D014230:Triazoles / Q000008:administration & dosage*; D014592:Uterine Hemorrhage / Q000188:drug therapy* / Q000209:etiology
D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole