[Expression and clinical significance of KiSS-1 and E-cadherin in gastric cardia carcinoma].
OBJECTIVE
To investigate the expression and clinical significance of KiSS- 1 and E- cadherin in gastric cardia carcinoma and the correlation between the two proteins.


METHODS
The expression of KiSS- 1 and E- cadherin in 80 patients with gastric cardia carcinoma and 20 patients with normal gastric cardia epithelium was detected by immunohistochemical technique.


RESULTS
The expression of KiSS- 1 was negatively correlated with lymphatic metastasis and clinical stage (P < 0.05), but not correlated with the cancer differentiation (P < 0.05). The expression of E- cadherin was negatively correlated with lymphatic metastasis, clinical stage, and cancer differentiation (P < 0.05). Spearman test showed a positive correlation between KiSS- 1 and E- cadherin expression (r(s)=0.722, P < 0.05).


CONCLUSIONS
KiSS- 1 and E- cadherin may play important roles in inhibiting the invasion and metastasis of gastric cardia carcinoma.
Department of Oncology, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China.
Zhan-hui
ZH
Wang
Xiao-shan
XS
Feng
Gong-ping
GP
Wang
She-gan
SG
Gao
Jian-qiang
JQ
Mi
Jiang-Tao
JT
Sun
Zhi-feng
ZF
Qu
Jing
J
Han
Luo
L
Zhang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000378:metabolism*; D002299:Cardia / Q000473:pathology; D005260:Female; D006801:Humans; D059648:Kisspeptins; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
D015820:Cadherins; C106628:KISS1 protein, human; D059648:Kisspeptins; D025521:Tumor Suppressor Proteins