A new necessary condition on interaction graphs for multistationarity.
We consider a dynamical system, described by a system of ordinary differential equations, and the associated interaction graphs, which are defined using the matrix of signs of the Jacobian matrix. After stating a few conjectures about the role of circuits in these graphs, we prove two new results relating them to the dynamic behaviour of the system: a sufficient condition for qualitative unstability, and a necessary condition for the existence of several stationary states. These results are illustrated by examples of regulatory modules in two variables, such as those occurring in biological networks.
Unit of Theoretical and Computational Biology, Faculté des Sciences, Université Libre de Bruxelles (U.L.B.), Campus Plaine, C.P. 231, B-1050 Brussels, Belgium. Marcelle.Kaufman@ulb.ac.be
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Kaufman
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Soulé
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Thomas
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D005246:Feedback; D006706:Homeostasis; D008954:Models, Biological; D013598:Systems Theory