Relationship between interleukin-1beta and lipids in type 1 diabetic patients.
BACKGROUND
The auto-immune response leading to type 1 diabetes (T1D) is closely associated with the overproduction of T helper-1 (Th1) cytokines which activate macrophage production of inflammatory mediators such as interleukin (IL)-1beta. The principal aim of this study was to elucidate whether IL-1beta is associated with the development of the inflammatory state of disease and the altered circulating lipid levels in T1D.


METHODS
Sixty-nine T1D and 74 age-matched non-diabetic (ND) subjects were recruited from the outpatient department of Internal Medicine, University Medical Center, Tlemcen, Algeria.


RESULTS
The levels of IL-1beta, CRP, HbA1c, CHOL, and LDLc, but not of HDLc, were significantly higher in all T1D subjects than in the ND controls. IL-1beta and CRP were found to be associated with T1D (OR>1). Newly diagnosed T1D subjects exhibited significantly higher IL-1beta, but not CRP, concentrations than controls and long-standing diabetic subjects. TG and HbA1c levels were not statistically different in the two diabetic populations. However, CHOL and LDLc concentrations were significantly higher in long-standing patients than in newly diagnosed ones. HDLc fractions were lower in long-standing patients than in controls and newly diagnosed diabetic subjects. Furthermore, the plasmatic concentrations of IL-1beta, but not of CRP, negatively correlated with CHOL, LDLc, or TG levels and positively with those of CRP in T1D patients.


CONCLUSIONS
IL-1beta seems to be associated with the type 1 diabetes inflammatory process. Moreover, a reciprocal relationship exists between newly diagnosed and long-standing T1D patients as far as the levels of this cytokine and circulating lipids are concerned.
Department of Biology, Djillali Liabes University, Biotoxicology Laboratory, National Research Center, Sidi-Bel-Abbes, Algeria.
Mourad
M
Aribi
Soraya
S
Moulessehoul
Mohammed
M
Kendouci-Tani
Ahmed-Bakir
AB
Benabadji
Aziz
A
Hichami
Naim Akhtar
NA
Khan
D000293:Adolescent; D000328:Adult; D001327:Autoimmune Diseases / Q000378:metabolism; D002097:C-Reactive Protein / Q000737:chemistry; D002648:Child; D016207:Cytokines / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000378:metabolism / Q000628:therapy; D005260:Female; D006442:Glycated Hemoglobin / Q000096:biosynthesis; D006801:Humans; D007249:Inflammation; D053583:Interleukin-1beta / Q000097:blood* / Q000378:metabolism; D008055:Lipids / Q000097:blood* / Q000737:chemistry; D008297:Male; D015233:Models, Statistical
D002097:C-Reactive Protein; D016207:Cytokines; D006442:Glycated Hemoglobin; D053583:Interleukin-1beta; D008055:Lipids; C517652:hemoglobin A1c protein, human