[Differential diagnosis of hypoparathyroidism and the Ellsworth-Howard's test].
Presence of hypocalcemia along with normo- or hyper-phosphatemia in the absence of decreased renal function strongly suggests hypoparathyroidism. The first step of differential diagnosis is the measurement of serum intact-PTH level. Less than 30 pg/mL of serum intact-PTH means decreased secretion of PTH, most often associated with post-surgical or idiopathic hypoparathyroidism, and hypomagnesemia. Serum intact-PTH values of 30 pg/mL or more suggest psuedohypoparathyroidism (PHP). In the latter case, to confirm decreased PTH responsiveness, Ellsworth-Howard's test or PTH loading test should be performed.
Teikyo University Chiba Medical Center, Third Department of Medicine, Japan.
Ryo
R
Okazaki
D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D003940:Diagnostic Techniques, Endocrine; D006801:Humans; D006996:Hypocalcemia / Q000209:etiology; D007011:Hypoparathyroidism / Q000145:classification / Q000150:complications / Q000175:diagnosis*; D010281:Parathyroid Hormone / Q000097:blood*; D010710:Phosphates / Q000097:blood; D011547:Pseudohypoparathyroidism / Q000145:classification / Q000175:diagnosis
D015415:Biomarkers; D010281:Parathyroid Hormone; D010710:Phosphates