A pilot-controlled study of myeloperoxidase-specific anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) in the coronary circulation.
Hereby we report our observations derived from a pilot-study of 39 subjects (30 patients with coronary artery disease [CAD] and 9 non-CAD controls). In this work, we aimed to evaluate MPO-ANCA titer in the human coronary circulation for the first time; and examine its possible association with CAD and some cytokines/inflammatory markers. We found higher mean coronary MPO-ANCA titer in CAD subjects than in non-CAD controls; beside significant positive correlations between MPO-ANCA titers and both C-reactive protein and interleukin-6 levels. Thus, we might suggest the possible involvement of MPO-ANCA in coronary atherogenesis indirectly through modulating some pro-inflammatory cytokines/markers; that a large-scale study of MPO-ANCA in CAD patients may be warranted in the future.
Ramadan
Mahmoud M
MM
Tachikawa
Hitoshi
H
Kodama
Makoto
M
Okawara
Akiko
A
Mitsuma
Wataru
W
Ito
Masahiro
M
Kashimura
Takeshi
T
Ikrar
Taruna
T
Hirono
Satoru
S
Okura
Yuji
Y
Suzuki
Kazuo
K
Aizawa
Yoshifusa
Y
D000368:Aged; D000369:Aged, 80 and over; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003326:Coronary Circulation; D003327:Coronary Disease / Q000276:immunology*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000276:immunology; D010865:Pilot Projects; D012307:Risk Factors
D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein; D009195:Peroxidase