Role of nitric oxide during neurogenesis in the olfactory epithelium.
In mammals, neurogenesis continues during adulthood in restricted places of the nervous system, namely the subventricular zone, the dentate gyms and the olfactory epithelium. A dual role of the second messenger nitric oxide has been reported in such places, either promoting or inhibiting proliferation of neuronal precursors depending on the cellular signal implicated. In this review the regulation of adult olfactory epithelium neurogenesis by nitric oxide is discussed.
Instituto de Dinámica Celular y Biotecnología, Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Chile. lsulz@uchile.cl
Lorena
L
Sulz
Juan
J
Bacigalupo
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism*; D009831:Olfactory Mucosa / Q000166:cytology*; D013234:Stem Cells / Q000502:physiology
D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II