POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin lesions) syndrome: a South America's report.
The POEMS syndrome, also known as Crow-Fukase syndrome, is an unusual systemic disorder described mainly in Asian individuals. It is characterized by the presence of (P)polyneuropathy, (O)organomegaly, (E)endocrinopathy, (M) M-protein, and (S) skin changes. Several other associated conditions such as sclerotic bone lesions, Castleman disease, low-grade fever, edema and hematologic disorders are usually seen. We describe five Brazilian patients with this syndrome. Two patients presented Castleman disease, one patient presented osteosclerotic myeloma and in two patients no associated conditions were found.
Postgraduate Program on Neurology / Neuroscience from The Fluminense Federal University.
Ana Claudia Celestino
AC
Leite
Osvaldo J M
OJ
Nascimento
Marco Antonio
MA
Lima
Maria José
MJ
Andrada-Serpa
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D016878:POEMS Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy