Comparison of two different dosages of hydroxyzine for sedation in the paediatric dental patient.
OBJECTIVE
This study compared the effect of two different dosages of hydroxyzine supported by 50% nitrous oxide inhalation sedation in child patients.


METHODS
Thirty uncooperative healthy children with an age range of 31-120 months were included in this study. Patients were randomly assigned into two groups. The patients in group 1 were given 20 mg of hydroxyzine (Atarax) 24 h preoperatively and on the operation day, 3.7 mg/kg hydroxyzine was administered orally. The patients in group 2 received 3.7 mg/kg hydroxyzine orally only on the operation day. All patients also received 50% nitrous oxide inhalation sedation. The child's behaviour was evaluated every 5 min by using Houpt Sedation Rating Scale. The oxygen saturation and heart rates were also followed.


RESULTS
The mean age of the children in the study was 61.9 months (SD 11.9) for group 1 and 53.7 months (SD 12.8) for group 2. Evaluation of the results showed that there were no significant differences (P < 0.05) between behavioural attitudes and sedation degree of the patients.


CONCLUSIONS
Twenty milligrams of hydroxyzine administered 24 h preoperatively has no significant benefit on sedation of the child.
Department of Pedodontics, Faculty of Dentistry, University of Ankara, Ankara, Turkey.
Mahmoud
M
Faytrouny
Zeynep
Z
Okte
Zuhal
Z
Kucukyavuz
D000766:Anesthesia, Dental; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage; D002355:Carticaine / Q000008:administration & dosage; D002648:Child; D002652:Child Behavior; D002675:Child, Preschool; D003448:Crying; D016854:Dental Anxiety / Q000517:prevention & control; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D009068:Movement; D009609:Nitrous Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000097:blood; D011229:Preanesthetic Medication; D016037:Single-Blind Method; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D018685:Anesthetics, Inhalation; D000779:Anesthetics, Local; D006993:Hypnotics and Sedatives; D006919:Hydroxyzine; D002355:Carticaine; D009609:Nitrous Oxide; D010100:Oxygen