[Subclinical Cushing's disease: presentation of three cases and critical review].
Unlike subclinical Cushing's disease, adrenal subclinical Cushing's syndrome is widely recognized. It is defined as an autonomous cortisol hyperproduction of mild intensity not causing specific clinical signs, but detectable biochemically as derangements of the hypothalamic-pituitary-adrenal axis function. Although Cushing's disease accounts for the majority of hypercortisolism states, subclinical Cushing's disease has been rarely reported. Three cases of subclinical Cushing's disease due to pituitary corticotrophic macroadenomas, confirmed by immunohistochemistry, are presented in order to underscore its recognition by clinical endocrinologists and to emphasize a diagnostic evaluation of hypercortisolism in all cases of pituitary adenomas.
Serviço de Endocrinologia, Santa Casa de Belo Horizonte, Belo Horizonte, MG.
Bárbara C Carvalho
BC
Silva
Alfredo M
AM
Baruqui Júnior
Víctor Eurípedes
VE
Barbosa
Gil Patrus Mundim
GP
Pena
Marisa Helena de F
MH
Campos
Adauto Versiani
AV
Ramos
Eduardo Pimentel
EP
Dias
D000236:Adenoma / Q000150:complications* / Q000473:pathology; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003480:Cushing Syndrome / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications* / Q000473:pathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D013974:Thyroxine