[Peroxisome proliferator-activated receptor gamma (PPARgamma): molecular study in glucose homeostasis, lipid metabolism and therapeutic approach].
The peroxisome proliferators-activated receptors (PPARs) are transcription factors belonging to the family of nuclear receptors that regulate glucose homeostasis, lipid metabolism and inflammation. Three proteins, encoded by distinct genes, have been identified: PPARalpha, PPARbeta and PPARgamma, which control gene expression by binding to specific response elements (PPREs) in the promoters. Recent studies suggest that activation of PPARgamma might decrease atherosclerosis progression and increase the insulin sensitivity, might be a potential therapeutic target for the treatment of a diverse array of disorders, including type 2 diabetes and dyslipidaemia. This review highlights recent studies, which have advanced our understanding of the pivotal role that this receptor plays in metabolism, with particular reference to the molecular mechanisms and therapeutic efficacy.
Tavares
Vladimir
V
Programa de Pós-Graduação em Farmácia, Area de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av. Prof. Lineu Prestes 580, 05508-900 São Paulo, SP. vladitav@usp.br
Hirata
Mario Hiroyuki
MH
Hirata
Rosario D Crespo
RD
D050197:Atherosclerosis / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D050171:Dyslipidemias / Q000188:drug therapy; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D050356:Lipid Metabolism / Q000502:physiology*; D047493:PPAR alpha / Q000235:genetics / Q000627:therapeutic use; D047495:PPAR gamma / Q000235:genetics* / Q000627:therapeutic use; D048068:PPAR-beta / Q000235:genetics / Q000627:therapeutic use; D011110:Polymorphism, Genetic; D014157:Transcription Factors / Q000235:genetics*
D018836:Inflammation Mediators; D047493:PPAR alpha; D047495:PPAR gamma; D048068:PPAR-beta; D014157:Transcription Factors; D005947:Glucose