Stable recovery from HCV in HIV-HCV co-infection under antiretroviral therapy.
Co-infection by the hepatitis C virus (HCV) and the human immunodeficiency virus (HIV) is common. HIV co-infection worsens the course of HCV infection, particularly in patients with low CD4-cell count, enhancing the need to cancel HCV replication in HIV-infected patients. We report a case of spontaneous recovery of chronic HCV-infection in a HCV-HIV co-infected hemophiliac with the introduction of combined antiretroviral therapy and immune restoration. Retrospective analysis of frozen blood samples showed that a decrease in HCV-RNA in parallel with the increase of CD4 and CD8-cell counts, accompanied by a peak of transaminases. The respective effect of immune restoration and of high doses of ritonavir are discussed.
AP-HP, hôpital Cochin, hépatologie, Paris, France.
Jean-David
JD
Zeitoun
Vincent
V
Mallet
Marie-Laure
ML
Chaix
Jean-Paul
JP
Viard
Stéphane
S
Blanche
Stanislas
S
Pol
D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1; D006467:Hemophilia A / Q000821:virology; D016174:Hepacivirus; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D008297:Male; D012367:RNA, Viral; D019438:Ritonavir / Q000627:therapeutic use*; D019562:Viral Load
D012367:RNA, Viral; D019438:Ritonavir