[The influence of small regulatory RNAs on the viral infection--new strategies in HCV therapy].
The discovery of the RNAi phenomenon drastically changed our thinking about the mechanisms affecting the expression of genetic information. It demonstrated that not only proteins but also small regulatory RNAs (srRNAs) are the key players in this process. In addition, it was shown that srRNAs can influence viral infections. They are able to mediate viral RNA degradation or to inhibit viral RNA replication and translation. The collected data suggest that srRNAs will soon become an important tool in our struggle with viruses.
Figlerowicz
Marek
M
Zespół Wirusologii Molekularnej, Instytut Chemii Bioorganicznej PAN w Poznaniu. marekf@ibch.poznan.pl
Tyczewska
Agata
A
Figlerowicz
Magdalena
M
D015967:Gene Expression Regulation, Viral; D016174:Hepacivirus / Q000235:genetics* / Q000378:metabolism; D006526:Hepatitis C / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D016896:Treatment Outcome; D014779:Virus Replication
D035683:MicroRNAs; D034741:RNA, Small Interfering