[Myeloma, Kaposi's sarcoma and HHV8 infection in hemodialyzed patient].
BACKGROUND
The association between Kaposi's sarcoma, Human Herpes Virus 8 infection and multiple myeloma is still controversial especially in hemodialysed patient.


OBJECTIVE
report a new case of this association.


METHODS
We report the case of a 83 year old man in whom the diagnosis of multiple myeloma of IgA/kappa had been made in December 2003 with end stage renal failure requiring hemodialysis. Initially, it had been treated with Melphalan, Cyclophosphamide, Prednisolone and Vincristine and secondary by Melphalan and Prednisone. Three months later, he had developed extensive porpour lesions in his lower limbs. Skin biopsy had been informed of Kaposi's sarcoma. Human Herpes Virus 8 test was positive.


CONCLUSIONS
Our observation is another case supporting the hypothesis that Kaposi's sarcoma and multiple myeloma share a common aetiology such as Human Herpes Virus 8. The immunodepressed state related to aging, multiple myeloma, chemotherapy and hemodialysis was the probable factor responsible of rapidly progressive Kaposi's sarcoma in our patient. The association myeloma and Human Herpes Virus 8 infection is still controversial.
Service de Médecine Interne A, Hôpital Charles Nicolle, Tunis, Tunisie.
Mohamed Mongi
MM
Bacha
Rym
R
Goucha
Karim
K
Zouaghi
Hela
H
Jebali
Bassima
B
Fazaa
Hafedh
H
Hedri
Fethi
F
El Younsi
Ezzeddine
E
Abderrahim
Fethi
F
Ben Hamida
Taïeb
T
Ben Abdallah
Fatma
F
Ben Moussa
Riadh
R
Kammoun
Hedi
H
Ben Maiz
Adel
A
Kheder
D000369:Aged, 80 and over; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D009101:Multiple Myeloma / Q000150:complications*; D006435:Renal Dialysis; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000821:virology; D012878:Skin Neoplasms / Q000150:complications* / Q000821:virology