Pulmonary toxicity by a cytotoxic agent, S-1.
A 72-year-old man with tongue carcinoma complained of dyspnea on exertion 18 days after starting treatment with S-1. Chest radiograph and CT scan suggested diffuse interstitial lesions with ground glass opacity on both lungs. Bronchoalveolar lavage and transbronchial lung biopsy revealed moderate lymphocyte infiltration with granuloma. Drug lymphocyte stimulation test was positive against tegafur, one of the components of S-1. These findings were consistent with S-1-induced lung injury. Both his symptoms and the radiographic findings were resolved dramatically after high-dose corticosteroid therapy. Clinicians should be aware that S-1 has the potential to cause lung injury when it is included in chemotherapy.
Respirology, Chiba University. ytada@faculty.chiba-u.jp
Yuji
Y
Tada
Yuichi
Y
Takiguchi
Ayako
A
Fujikawa
Atsushi
A
Kitamura
Katsushi
K
Kurosu
Kenzo
K
Hiroshima
Seiichiro
S
Sakao
Yasunori
Y
Kasahara
Nobuhiro
N
Tanabe
Koichiro
K
Tatsumi
Takayuki
T
Kuriyama
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D004338:Drug Combinations; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D010094:Oxonic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000473:pathology; D005641:Tegafur / Q000009:adverse effects* / Q000627:therapeutic use; D014062:Tongue Neoplasms / Q000188:drug therapy
D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid