Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents.
A series of cinnamyl compounds related to 2'-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G(2)/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.
Shin
Dae-Seop
DS
Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosung, Daejeon 305-333, Republic of Korea.
Kim
Jiin
J
Han
Dong Cho
DC
Son
Kwang-Hee
KH
Lee
Chang Woo
CW
Kim
Hwan-Mook
HM
Hong
Su Hyung
SH
Kwon
Byoung-Mog
BM
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000096:biosynthesis; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D002934:Cinnamates / Q000138:chemical synthesis* / Q000494:pharmacology*; D027424:Cinnamomum / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D016195:G2 Phase / Q000187:drug effects; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D000067856:Poly(ADP-ribose) Polymerase Inhibitors
D000970:Antineoplastic Agents; D002934:Cinnamates; D004791:Enzyme Inhibitors; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D053148:Caspase 3