Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis.
BACKGROUND
The purpose of this study was to examine the association between 4 Fas single nucleotide polymorphisms (SNPs) and risk of differentiated thyroid carcinoma (DTC) and salivary gland carcinoma (SGC).


METHODS
We conducted a case-control study including 279 DTC cases, 165 benign thyroid disease (BTD) cases, 154 SGC cases, 61 benign salivary gland disease (BSGD) cases, and 510 controls.


RESULTS
The A744G SNP genotype distribution was significantly different between subjects with SGC or BSGD and controls, while that of the A18272G SNP was significantly different between subjects with DTC or SGC and controls. Risk of SGC was significantly elevated for the 22628 heterozygous CT genotype (odds ratio [OR] = 1.5, p = .050), and risk of BSGD was elevated for the 22628 homozygous TT genotype (OR = 2.9, p = .023).


CONCLUSIONS
Fas C22628T SNP may be associated with risk of SGC and BSGD, but none of the investigated Fas SNPs was associated with risk of DTC.
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.
Tang
T
Ho
Guojun
G
Li
Chong
C
Zhao
Rong
R
Zheng
Qingyi
Q
Wei
Erich M
EM
Sturgis
D002277:Carcinoma / Q000235:genetics*; D016022:Case-Control Studies; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012466:Salivary Gland Diseases / Q000235:genetics; D012468:Salivary Gland Neoplasms / Q000235:genetics*; D013959:Thyroid Diseases / Q000235:genetics; D013964:Thyroid Neoplasms / Q000235:genetics*; D019014:fas Receptor / Q000235:genetics*
C491901:FAS protein, human; D019014:fas Receptor