[Functional proteomics in oncology: to understand more than to describe].
Like other -omics, proteomics is traditionally understood as a method that allows a global description of molecular content (here proteins) of a biological sample, used to identify new biomarkers in diseases such as cancers. Proteomics is also a powerful tool to identify the molecular mechanisms of diseases. In cancer, deregulation of cell growth and migration is related to alterations in cell signalling and the numerous alterations in protein-protein and protein-nucleic acid interactions that account for the malignant phenotype are only partly understood. Based on its capacity to separate and identify proteins, including those with post-translational modifications, proteomics provides new ways to understand post-genomic events that contribute to transformation and to identify new therapeutic targets.
ERI-8 Inserm (JE-2488), Signalisation des facteurs de croissance dans le cancer du sein, France.
Emmanuelle
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Com
Hubert
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Hondermarck
D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis / Q000502:physiology; D008297:Male; D008495:Medical Oncology / Q000379:methods*; D009363:Neoplasm Proteins / Q000032:analysis / Q000502:physiology*; D025941:Protein Interaction Mapping; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods*; D015398:Signal Transduction
D014408:Biomarkers, Tumor; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins