[Health-related quality of life in multiple sclerosis].
Multiple sclerosis (MS) is a chronic disease which may exert significant effects on the life of patients. Traditional outcome measures in MS lack in consider the effects of the disease on health-related quality of life (HRQoL). The goal of this study is to measure HRQoL in MS patients in the city of Uberlândia, State of Minas Gerais, Brazil. The Brazilian version of the SF-36 was applied in 23 MS patients and in 69 subjects of general population (blood donors) in Uberlândia. MS patients scored lower in all SF-36 scales than do the general population, principally in physical function domains. Patients with EDSS scores < or =3.5 had higher mean scores in four domains than do the patients with EDSS scores > or =4.0, and lower in all domains than control group. Depressive symptoms and heat intolerance showed correlation with SF-36 domains and components. In conclusion, MS patients have a significant negative impact on all HRQoL domains measured by SF-36, compared with general population, even in the stages with lower disability.
Médico Neurologista da UFU. rogerio.morales@netsite.com.br
Rogério de Rizo
Rde R
Morales
Nívea de Macedo Oliveira
Nde M
Morales
Fernando Coronetti Gomes da
FC
Rocha
Sheila Bernardino
SB
Fenelon
Rogério de Melo Costa
Rde M
Pinto
Carlos Henrique Martins da
CH
Silva
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000523:psychology*; D011788:Quality of Life; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires