Evaluation of wound-healing potential of Catharanthus roseus leaf extract in rats.
Rats treated with 100 mg /kg/day of the Catharanthus roseus ethanol extract had high rate of wound contraction significantly decreased epithelization period, significant increase in dry weight and hydroxyproline content of the granulation tissue when compared with the controls. Wound contraction together with increased tensile strength and hydroxyproline content support the use of C. roseus in the management of wound healing.
Department of Pre Clinical Sciences, Biochemistry Unit, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago. snayak@fms.uwi.tt
B S
BS
Nayak
M
M
Anderson
L M
LM
Pinto Pereira
D000818:Animals; D030008:Catharanthus; D004305:Dose-Response Relationship, Drug; D006097:Granulation Tissue / Q000187:drug effects; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy
D010936:Plant Extracts