Nerve-sparing radical retropubic prostatectomy in patients previously submitted to holmium laser enucleation of the prostate for bladder outlet obstruction due to benign prostatic enlargement.
OBJECTIVE
To evaluate the feasibility and safety of nerve-sparing radical retropubic prostatectomy (NSRRP) for localised prostate cancer after holmium laser enucleation of the prostate (HoLEP) for bladder outlet obstruction due to benign prostatic enlargement (BPE).


METHODS
Fifteen consecutive patients with prostate cancer following HoLEP underwent NSRRP. They were matched with an equal number of patients who also underwent NSRRP following transurethral resection of the prostate (TURP group) or open prostatectomy (OP group). Patients were preoperatively assessed with validated questionnaires (International Prostate Symptom Score [IPSS] and International Index of Erectile Function-Erectile Function [IIEF-EF]). Intraoperative, perioperative, and follow-up functional data according to validated questionnaires (IPSS, IIEF-EF, International Consultation on Incontinence Questionnaire-Short Form [ICIQ-SF]) were evaluated with analysis of variance and chi2 tests.


RESULTS
At diagnosis, the prostate-specific antigen (PSA) level, clinical stage, Gleason sum distributions, body mass index, ICIQ-SF, and IPSS were not significantly different among the groups. IIEF-EF scores was higher in the HoLEP group (p=0.02). Mean operative time was longer in the OP group (p=0.02), but no difference was found in mean blood loss (p=0.5). Final pathology showed no substantial differences among the groups, although a lower positive surgical margin rate was found in the HoLEP group (p=0.04). Mean follow-up was 23.8+/-10.5 mo. The groups showed no statistical differences in urinary continence rate (p=0.6), IPSS (p=0.3), or IIEF-EF (p=0.4).


CONCLUSIONS
NSRRP is feasible in prostate cancer patients who previously underwent HoLEP for BPE and provides satisfactory functional outcomes.
Department of Urology, University Vita-Salute San Raffaele, Milan, Italy. suardi.nazareno@hsr.it <suardi.nazareno@hsr.it>
Nazareno
N
Suardi
Vincenzo
V
Scattoni
Alberto
A
Briganti
Andrea
A
Salonia
Richard
R
Naspro
Andrea
A
Gallina
Andrea
A
Cestari
Renzo
R
Colombo
Pierre I
PI
Karakiewicz
Giorgio
G
Guazzoni
Patrizio
P
Rigatti
Francesco
F
Montorsi
D000368:Aged; D005240:Feasibility Studies; D006801:Humans; D053685:Laser Therapy; D053844:Lasers, Solid-State; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000379:methods*; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000601:surgery*; D011471:Prostatic Neoplasms / Q000601:surgery*; D001748:Urinary Bladder Neck Obstruction / Q000209:etiology* / Q000601:surgery*