Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera.
The major constituents from the fruits of Maclura pomifera are the prenylated isoflavones, osajin (1) and pomiferin (2). Their structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 2 showed potential inhibitory activity in histone deacetylase (HDAC) enzyme assay. It also exhibited growth inhibitory activity on five human tumor cell lines and more sensitive inhibitory activity on the HCT-15 colon tumor cell line. Further structure-activity relationships of position 3 on ring B from aromatic ring will be reported in due course.
Department of Neuroscience, Inam Neuroscience Research Center, Sanbon Medical Center, Wonkwang University, Gunpo-City, Kyunggido, South Korea.
Il Hong
IH
Son
Ill-Min
IM
Chung
Sung Ik
SI
Lee
Hyun Duk
HD
Yang
Hyung-In
HI
Moon
D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D007529:Isoflavones; D031624:Maclura / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000302:isolation & purification*; D013329:Structure-Activity Relationship
D001578:Benzopyrans; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D007529:Isoflavones; D010936:Plant Extracts; C474837:pomiferin