The role of dendritic cells in the immunopathogenesis of psoriasis.
Psoriasis vulgaris is a chronic inflammatory skin disease that is marked by a complex interplay of dendritic cells (DCs), T-cells, cytokines, and downstream transcription factors as part of a self-sustaining type 1 cytokine network. As integral players of the immune system, DCs represent antigen-presenting cells that are crucial for efficient activation of T-cells and B-cells. DCs have also been linked to distinct chronic inflammatory conditions, including psoriasis. In the setting of psoriasis therapy, DC/T cell interactions serve as a potential target for biologic response modifiers. Here we describe the major DC subsets as well as the immunologic involvement of DCs within the context of psoriatic lesions.
Department of Internal Medicine, Albert Einstein/Montefiore Medical Center, 33 Teal Court, East Windsor, NJ 08520, USA. sjariwal@montefiore.org
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Jariwala
D002450:Cell Communication / Q000276:immunology; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology* / Q000473:pathology*; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology