Impact of the metabolic syndrome on total arterial compliance in essential hypertension patients.
The aim of the study was to cross-sectionally analyze, in a group of essential hypertension patients without diabetes mellitus, the influence of the metabolic syndrome (MS) on the stroke volume index to pulse pressure (SVi/PP) ratio, a measure of total arterial compliance. A total of 528 essential hypertension patients, aged 18 to 72 years, free from cardiovascular and renal disease (41% of whom had MS) were enrolled. All participants underwent routine blood chemistry, echocardiographic examination, and 3 blood pressure measurements at the end of echocardiographic examination. When compared with participants who did not have MS, hypertensive patients with MS exhibited lower SVi/PP ratio (0.65+/-0.22 vs 0.73+/-0.21 mm Hg; P=.0003). The independent association of MS with SVi/PP ratio (beta=0.10; P=.02) was confirmed in a multivariate regression model including age, sex, and other potential confounders as covariates. The authors' finding may help to explain the enhanced cardiovascular risk associated with MS.
Mulé
Giuseppe
G
Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Universitá di Palermo, Italy. giusemme@unipa.it
Nardi
Emilio
E
Cottone
Santina
S
Cusimano
Paola
P
Palermo
Alessandro
A
Incalcaterra
Francesca
F
Giandalia
Maria Ester
ME
Cerasola
Giovanni
G
D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D013318:Stroke Volume