Probe-guided localization of cancer deposits using [18F]fluorodeoxyglucose.
In recent years, several probes have been developed to allow for the intraoperative detection of tumour tissue using [18F]fluorodeoxyglucose (FDG). Detector designs include high-energy gamma and beta probes, as well as combination devices with background rejection capabilities. Some laboratory prototypes and commercialized systems have demonstrated reasonable sensitivities for 511 keV photons and /or b particles emitted from 18F for in vivo use. This review focuses on the ability of these devices to detect tumour deposits in the low-contrast environment of the operating room . Important technical and biological factors that influence tumour-to-background contrast are discussed and potential future applications and developments are highlighted. In addition, we evaluate the limited data on absorbed doses resulting from [18F] FDG administration immediately prior to surgery that indicate acceptable levels of radiation exposure to operating room personnel.
Department of Radiology, University of Michigan, MI 48109-0028, USA. mpiert@umich.edu
M
M
Piert
J
J
Carey
N
N
Clinthorne
D019788:Fluorodeoxyglucose F18; D006282:Health Personnel; D006801:Humans; D007432:Intraoperative Period; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D009873:Operating Rooms; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods; D011829:Radiation Dosage; D019275:Radiopharmaceuticals
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18