Role of metalloproteinases in platelet function.
Platelets contain and release matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and disintegrin metalloproteinases (ADAMs) including MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP (MMP-14), ADAM-10, ADAM-17, ADAMTS-13, TIMP-1, TIMP-2 and TIMP-4. These proteins exert several effects regulating platelet functions such as agonist-stimulated platelet adhesion and aggregation, tumour cell-induced platelet aggregation and platelet-leukocyte aggregation. In this review, mechanisms of MMPs, TIMPs and ADAMs on platelets are discussed.
School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin, Ireland.
María José
MJ
Santos-Martínez
Carlos
C
Medina
Paul
P
Jurasz
Marek W
MW
Radomski
D051722:ADAM Proteins / Q000502:physiology; D000072198:ADAM17 Protein; D000071120:ADAMTS13 Protein; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology; D045726:Metalloproteases / Q000502:physiology*; D010974:Platelet Aggregation; D014652:Vascular Diseases / Q000209:etiology
D045726:Metalloproteases; D051722:ADAM Proteins; D000072198:ADAM17 Protein; C000606462:ADAM17 protein, human; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human