Determination of optimal dose of arginine vasopressin in hemorrhagic shock in dogs.
The hemodynamic effects of vasopressin of high/low doses on dogs were investigated using experimentally induced hemorrhagic shock model. Experimental groups were categorized according to administered doses of vasopressin (0.1, 0.4 and 1.6 IU/kg) and hemodynamic parameters were measured before and after the graded-dose administration of vasopressin. Administration of high- and middle-dose vasopressin (0.4 and 1.6 IU/kg) showed superior increase in blood pressure and systemic vascular resistance, compared with those of low-dose one (0.1 IU/kg). Results of systolic arterial pressure and mean arterial pressure in 1.6 IU/kg-administered group revealed lower efficacy than that in 0.4 IU/kg group in spite of administration of higher dose. This study demonstrates that 0.4 IU/kg of vasopressin can be used as the most effective dose for improving hemodynamic condition in the decompensatory phase of hemorrhagic shock in dogs.
Yoo
Jong-Hyun
JH
BK21 Program of Integrative Network Systems for Veterinarians in Basic Science, Industrial Animals and Preventive Medicines, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul, South Korea.
Park
Chul
C
Hahm
Dae-Hyun
DH
Lee
Hye-Jung
HJ
Park
Hee-Myung
HM
D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004283:Dog Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous / Q000662:veterinary; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000503:physiopathology / Q000662:veterinary*; D014655:Vascular Resistance / Q000187:drug effects
D001127:Arginine Vasopressin