Neurite outgrowth: a flick of the wrist.
A new study has shown that, near the tip of a growing axon, dephosphorylation of the microtubule-associated protein Doublecortin is controlled by protein phosphatase 1 and its regulator spinophilin. This results in spatially regulated microtubule bundling within the axon and more efficient axon outgrowth.
Dehmelt
Leif
L
Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Halpain
Shelley
S
D000818:Animals; D000089622:Doublecortin Domain Proteins; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D016501:Neurites / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism; D010766:Phosphorylation
D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides