In vitro antibacterial activities of tigecycline and comparative agents by time-kill kinetic studies in fresh Mueller-Hinton broth.
Time-kill kinetics performed with tigecycline, in fresh MHB, demonstrated a consistent 1 to 2 log(10) CFU/ml reduction in bacterial counts against the majority of clinically relevant pathogens tested. Although classified as a bacteriostatic agent, tigecycline shows bactericidal activity against select isolates associated with serious infection. In general, vancomycin and imipenem demonstrated bactericidal activity.
Infectious Disease Discovery Research, Biological Technologies, Wyeth Research, Pearl River, NY 10965, USA. petersp@wyeth.com
Peter J
PJ
Petersen
C Hal
CH
Jones
Patricia A
PA
Bradford
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D003470:Culture Media; D024881:Drug Resistance, Bacterial; D016946:Gram-Negative Aerobic Rods and Cocci / Q000187:drug effects; D006095:Gram-Positive Cocci / Q000187:drug effects; D006801:Humans; D015378:Imipenem / Q000493:pharmacokinetics; D008826:Microbial Sensitivity Tests / Q000379:methods*; D008911:Minocycline / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000078304:Tigecycline; D014640:Vancomycin / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D003470:Culture Media; D014640:Vancomycin; D000078304:Tigecycline; D015378:Imipenem; D008911:Minocycline