[Relationship between hepatitis B virus genotypes and liver fibrosis].
OBJECTIVE
To study the relationship between hepatitis B virus (HBV) genotypes and liver fibrosis.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism method was employed to determine HBV genotypes in 298 HBV-related liver disease patients, including 73 with hepatocellular carcinoma, 53 with liver cirrhosis, 91 with chronic hepatitis B and 82 asymptomatic HBV carriers to analyze the relationship of HBV genotypes with serum fibrous indices and serum albumin and globulin (A/G) ratio.


RESULTS
B and C genotypes were dominant in patients with HBV-related hepatic diseases in Guangdong province. The levels of serum fibrous indices were significantly higher in patients with genotype C than in those with genotype B, and the former patients also had lower A/G ratio.


CONCLUSIONS
Patients with HBV genotype C may sustain more serious liver injury.
Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Yue-hua
YH
Huang
Zhi-jian
ZJ
Yu
Cheng
C
Wang
Bin
B
Zhou
Jin-lin
JL
Hou
D000328:Adult; D005260:Female; D005838:Genotype; D006515:Hepatitis B virus / Q000235:genetics* / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000097:blood / Q000821:virology; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000821:virology*; D008297:Male; D008875:Middle Aged