Drug-induced linear immunoglobulin A bullous dermatosis mimicking Stevens-Johnson syndrome: a case report.
Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare autoimmune disorder characterized by vesiculobullous mucocutaneous eruptions. LABD also has been reported as a drug-induced reaction. Idiopathic LABD and drug-induced LABD are clinically indistinguishable and can resemble bullous pemphigoid, dermatitis herpetiformis, or bullous erythema multiforme. LABD is diagnosed with direct immunofluorescence (DIF), and idiopathic LABD can be distinguished from drug-induced LABD with a careful medication history. We present the case of a 54-year-old man with drug-induced LABD after ingestion of rimantadine, zanamivir, and azithromycin for presumed influenza. The patient's bullous eruption resolved with discontinuation of the offending medications and treatment with prednisone and pentoxifylline.
University of Texas Medical Branch, Galveston TX 77550, USA. jecummin@utmb.edu
Julie E
JE
Cummings
Renee R
RR
Snyder
Erica B
EB
Kelly
Sharon S
SS
Raimer
D000890:Anti-Infective Agents / Q000009:adverse effects*; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000473:pathology*; D017963:Azithromycin / Q000009:adverse effects; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000188:drug therapy / Q000473:pathology*; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012299:Rimantadine / Q000009:adverse effects; D012867:Skin / Q000473:pathology*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis; D053243:Zanamivir / Q000009:adverse effects
D000890:Anti-Infective Agents; D007070:Immunoglobulin A; D012299:Rimantadine; D017963:Azithromycin; D053243:Zanamivir