[Interleukin-4 and cardiac fibrosis in patients with heart failure].
Interleukin-4 (IL-4) stimulates inflammatory responses, activates collagen synthesis, promotes fibrosis progression, and inhibits the production of inflammatory cytokines. We studied the relationship between the urinary IL-4 level and levels of markers of cardiac fibrosis and left ventricular volume in 98 patients with heart failure (HF). The left ventricular end-systolic volume index (LVESVI) and left ventricular end-diastolic volume index (LVEDVI) were calculated, and IL-4, tumor necrosis factor-alpha (TNF-alpha), IL-6, and aminoterminal propeptide of procollagen type III (PIIINP) levels were recorded. Comparison of urinary IL-4 and PIIINP levels in patients and control subjects gave values of 12 (12) pg/mL and 4 (3) pg/mL (P<.0001), respectively, and 5 (2) ng/mL and 4 (1) ng/mL (P<.0001), respectively. The IL-4 level correlated with LVESVI and LVEDVI (r = -0.22, P<.05), and with PIIINP (r = 0.24, P<.05). In patients with hypertensive cardiomyopathy, there was a good correlation between IL-4 and PIIINP levels (r = 0.7, P<.01). Correlations were also observed between IL-4 and TNF-alpha (r = 0.3, P<.01) and IL-6 (r = 0.5, P<.0001). The urinary IL-4 level correlated with cardiac fibrosis and remodeling in patients with HF. The relationship was stronger in those with hypertensive cardiomyopathy.
Unidad de Cardiología, Centro de Investigación Hospital La Fe, Valencia, España.
Esther
E
Roselló-Lletí
Miguel
M
Rivera
Vicente
V
Bertomeu
Raquel
R
Cortés
Alejandro
A
Jordán
Andrés
A
González-Molina
D000368:Aged; D005260:Female; D005355:Fibrosis; D006333:Heart Failure / Q000150:complications / Q000473:pathology* / Q000652:urine*; D006801:Humans; D015847:Interleukin-4 / Q000652:urine*; D008297:Male; D009206:Myocardium / Q000473:pathology*
D015847:Interleukin-4