Changes in the adaptive behavior of active and passive wistar rats in a water immersion model of depression.
Animals with active and passive strategies of adaptive behavior were selected from a population of Wistar rats by testing in a T maze to measure the indexes of behavioral passivity and behavioral activity. After single (stress) or two (stress-restress) water immersions, individual changes in adaptive behavior were used to study the development of post-stress psychopathology and its interaction with the initial behavioral strategy. In the unavoidable aversive environment, active and passive rats developed different types of post-stress depression, only passive individuals fulfilling the criteria of post-traumatic stress disorder.
Shalyapina
V G
VG
Neuroendocrinology Laboratory, I. P. Pavlov Institute of Physiology, St. Petersburg. vera@infran.ru
Vershinina
E A
EA
Rakitskaya
V V
VV
Ryzhova
L Yu
LY
Semenova
M G
MG
Semenova
O G
OG
D000223:Adaptation, Psychological / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal; D003863:Depression / Q000209:etiology*; D004195:Disease Models, Animal; D007101:Immersion; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000150:complications*; D014867:Water
D014867:Water