Correlation of macrophage location and plaque stress distribution using USPIO-enhanced MRI in a patient with symptomatic severe carotid stenosis: a new insight into risk stratification.
High resolution, USPIO-enhanced MR imaging can be used to identify inflamed atherosclerotic plaque. We report a case of a 79-year-old man with a symptomatic carotid stenosis of 82%. The plaque was retrieved for histology and finite element analysis (FEA) based on the preoperative MR imaging was used to predict maximal Von Mises stress on the plaque. Macrophage location correlated with maximal predicted stresses on the plaque. This supports the hypothesis that macrophages thin the fibrous cap at points of highest stress, leading to an increased risk of plaque rupture and subsequent stroke.
Departments of Radiology, Addenbrooke's Hospital and the University of Cambridge, Cambridge, UK.
Simon
S
Howarth
Zhi-Yong
ZY
Li
R A
RA
Trivedi
J M
JM
U-King-Im
M J
MJ
Graves
P J
PJ
Kirkpatrick
J H
JH
Gillard
D000368:Aged; D001167:Arteritis / Q000378:metabolism / Q000473:pathology; D016893:Carotid Stenosis / Q000378:metabolism / Q000473:pathology*; D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement; D008264:Macrophages / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D013194:Staining and Labeling; D014018:Tissue Distribution
D003287:Contrast Media