Human papillomavirus infection and disease in the HIV+ individual.
HPV infection of both the genital tract and oral cavity of HIV+ men and women is increased. HPV-related pathology is also increased in the HIV+ individuals, usually with further increases seen for those HIV+ individuals with lower CD4 cell counts. Fortunately, the rates of cervical cancer and anal cancer are relatively low and not related to CD4 cell count. Treatment of the HIV+ individual with HPV-related disease is challenging and requires close long-term follow-up to prevent recurrent disease. The mechanism of how HPV and HIV interact is still not known but is more likely to be linked to immune suppression rather than a direct interaction between viruses. The newly developed HPV vaccines will likely have a significant impact on HPV-related disease in immunocompetent individuals. It remains to be seen what impact these vaccine will have on the immune depressed.
Tulane Health Sciences Center, Tulane Medical School, New Orleans, LA, USA.
Jennifer E
JE
Cameron
Michael E
ME
Hagensee
D006678:HIV / Q000276:immunology*; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D009055:Mouth / Q000821:virology; D009369:Neoplasms / Q000821:virology; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000502:physiology*; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology