Dopamine D2/D3 receptor binding in the anterior cingulate cortex and executive functioning.
The objective was to investigate the association between extrastriatal dopamine D(2)/D(3) receptor binding and performance on the Wisconsin Card Sorting Test (WCST), a measure of executive functioning. Thirty-two healthy volunteers performed the WCST and underwent positron emission tomography and a high-affinity D(2)/D(3) receptor tracer, [(11)C]FLB 457. All WCST error parameters, in particular nonperseverative errors, correlated positively with [(11)C]FLB 457 binding in the cognitive division of the right anterior cingulate cortex. An independent voxel-based receptor parametric mapping analysis confirmed these findings. The results indicate that executive functioning in healthy volunteers is modulated by D(2)/D(3) receptors in the anterior cingulate cortex.
Turku PET Centre, University of Turku, c/o Turku University Central Hospital, PO Box 52, FIN-20521 Turku, Finland.
Ville
V
Lumme
Sargo
S
Aalto
Tuula
T
Ilonen
Kjell
K
Någren
Jarmo
J
Hietala
D000328:Adult; D001665:Binding Sites; D015992:Body Mass Index; D003072:Cognition Disorders / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050637:Receptors, Dopamine D3 / Q000378:metabolism*; D012720:Severity of Illness Index
D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3