Genetic characterization of erythromycin- and methicillin-resistant community-acquired Staphylococcus aureus isolated from children in Texas.
Prevalence of Panton-Valentine leukocidin (PVL) toxin, SCCmec, and accessory gene regulator (agr) types were studied in 197 community-acquired methicillin-resistant Staphylococcus aureus (MRSA) from children in Texas. The majority of pediatric macrolide-resistant clindamycin-susceptible community-associated MRSA belonged to PVL(+)/SCC type IV/agr type I group with msrA gene encoding for macrolide resistance. PVL(-)/SCC type II/agr type II strains, although rare, were consistently present in the community throughout the study period.
Bogdanovich
Tatiana
T
Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA.
Aydin
Neriman
N
Chavez-Bueno
Susana
S
McCracken
George
G
Bozdogan
Bülent
B
Appelbaum
Peter C
PC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D001427:Bacterial Toxins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000382:microbiology; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004917:Erythromycin / Q000494:pharmacology*; D005098:Exotoxins / Q000235:genetics; D006801:Humans; D007956:Leukocidins / Q000235:genetics; D016106:Methicillin Resistance / Q000235:genetics*; D015995:Prevalence; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D013781:Texas
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004269:DNA, Bacterial; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D004917:Erythromycin