Cytomegalovirus reactivation after low-dose steroid treatment for hemolytic anemia in a patient with primary Epstein-Barr virus infection.
Cytomegalovirus reactivation is a well described event occurring after intensive therapeutic suppression of the immune function in patients with latent infection. Treatment protocols for suppression of the immune response often include high-dose steroids. However, it is not known whether even a low-dose steroid treatment can reactivate latent cytomegalovirus in otherwise healthy persons. We documented cytomegalovirus reactivation after low-dose steroid treatment for autoimmune hemolytic anemia as a complication of Epstein-Barr virus mononucleosis in an immunocompetent 21-year-old man.
Clinic of Infectious Diseases, University Hospital Center Rijeka, Croatia.
Biserka
B
Troselj-Vukic
Irena
I
Milotic
Franko
F
Milotic
Marija
M
Crnic-Martinovic
Blazenka
B
Grahovac
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy* / Q000276:immunology; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003587:Cytomegalovirus / Q000187:drug effects* / Q000235:genetics / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000139:chemically induced* / Q000276:immunology; D004279:DNA, Viral / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications / Q000276:immunology; D008134:Long-Term Care; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D009894:Opportunistic Infections / Q000139:chemically induced* / Q000276:immunology; D016133:Polymerase Chain Reaction; D014775:Virus Activation / Q000187:drug effects* / Q000276:immunology
D000893:Anti-Inflammatory Agents; D004279:DNA, Viral; D008775:Methylprednisolone