[Antineoplastic properties of extracellular fructoso-1,6-bisphosphatase of Bacillus subtilis 668 and preparation isolated from cultural liquids of Bacillus subtilis 7025].
It was shown for the first time that extracellular FBPase of B. subtilis 668 like the preparation obtained from culture liquid of B. subtilis B 7025 displays citotoxicity activity in respect of tumor cells of sarcoma 37 in vitro. It is shown that the preparations remove TA antigens from the surface of the tumor cell. It is supposed that the mechanisms of citotoxic effect of extracellular FBFase of B. subtilis 668 and preparation from the culture liquid of B. subtilis B 7025 in vitro on cells of sarcoma 37 is probably realized through the apoptosis.
Didenko
H V
HV
Dvorshchenko
O S
OS
Iastrebova
O V
OV
Potebnia
M H
MH
Panchenko
L P
LP
Skrypal'
I H
IH
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001412:Bacillus subtilis / Q000201:enzymology*; D045744:Cell Line, Tumor; D003470:Culture Media / Q000737:chemistry*; D045604:Extracellular Fluid / Q000201:enzymology*; D006597:Fructose-Bisphosphatase / Q000302:isolation & purification / Q000494:pharmacology*; D012511:Sarcoma 37 / Q000473:pathology
D000970:Antineoplastic Agents; D003470:Culture Media; D006597:Fructose-Bisphosphatase