Imipramine reverses the depressive symptoms in sepsis survivor rats.
OBJECTIVE
To evaluate the antidepressant effect of imipramine on depressive symptoms observed in sepsis survivors rats.


METHODS
Prospective, controlled experiment in an animal basic science laboratory.


METHODS
Male Wistar rats weighing 300-350 g.


METHODS
The rats underwent cecal ligation and perforation (CLP; sepsis group) with "basic support" (saline at 50 ml/kg immediately and 12 h after CLP plus ceftriaxone at 30 mg/kg and clindamycin at 25 mg/kg 6, 12, and 18 h after CLP) or sham-operated (control group). After 10 days of recovery rats received intraperitoneal injections of imipramine 10 mg/kg or saline and were subjected to the forced swimming test.


RESULTS
The observed increase in the immobility time in the forced swimming test in animals subjected to CLP, as a parameter of depressive behavior, was reversed by imipramine.


CONCLUSIONS
The depressive symptoms evaluated by forced swimming test had been reversed after imipramine administration. Our data provide evidence that CLP-induced depressive symptoms are sensitive to antidepressants.
Laboratório de Neurociências, Programa de Pós-Graduação Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, Brazil.
Lisiane
L
Tuon
Clarissa M
CM
Comim
Moises M
MM
Antunes
Larissa S
LS
Constantino
Roberta A
RA
Machado
Ivan
I
Izquierdo
João
J
Quevedo
Felipe
F
Dal-Pizzol
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001938:Brazil; D003863:Depression / Q000188:drug therapy* / Q000503:physiopathology; D007099:Imipramine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D051381:Rats; D018805:Sepsis / Q000523:psychology*; D016896:Treatment Outcome
D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine