The apoptosome: emerging insights and new potential targets for drug design.
Apoptosis plays a crucial role in tissue homeostasis, development and many diseases. The relevance of Apaf1, the molecular core of apoptosome, has been underlined in mitochondria-dependent apoptosis, which according to a growing body of evidence, is involved in various pathologies where the equilibrium of life-and-death is dysregulated, such as heart attack, stroke, liver failure, cancer and autoimmune diseases. Consequently, great interest has emerged in devising therapeutic strategies for regulating the key molecules involved in the life-and-death decision. Here we review recent progress in apoptosis-based pharmacological therapies and, in particular, we point out a possible role of the apoptosome as an emerging and promising pharmacological target.
D'Amelio
Marcello
M
Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143, Rome, Italy.
Tino
Elisa
E
Cecconi
Francesco
F
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D053478:Apoptosomes / Q000187:drug effects*; D020169:Caspases / Q000378:metabolism*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
D053478:Apoptosomes; D019253:Proto-Oncogene Proteins c-bcl-2; D020169:Caspases