Novel clusters of highly expressed genes accompany genomic amplification in breast cancers.
Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.
Ito
Emi
E
Department of Clinical Informatics, Tokyo Medical and Dental University School of Medicine, Tokyo, Japan.
Honma
Reiko
R
Yanagisawa
Yuka
Y
Imai
Jun-ichi
J
Azuma
Sakura
S
Oyama
Tetsunari
T
Ohwada
Susumu
S
Akiyama
Tetsu
T
Nomura
Nobuo
N
Inoue
Jun-ichiro
J
Watanabe
Shinya
S
Semba
Kentaro
K
D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D045744:Cell Line, Tumor; D002877:Chromosomes, Human / Q000235:genetics / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D010641:Phenotype
D009363:Neoplasm Proteins