A triterpene saponin from Lysimachia thyrsiflora L.
A triterpene saponoside (LTS-4) isolated from the underground parts of Lysimachia thyrsiflora L. was defined as 3-O-{beta-D-xylopyranosyl-(1 --> 2)-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranosyl}-cyclamiretin A. Structure assignment was performed on the basis of spectroscopic data including homo- and heteronuclear 1D and 2D NMR (COSY, TOCSY, NOESY, HETCOR, HMBC and DEPT) and FAB-MS studies. The compound was tested in vitro for antimicrobial and cytotoxic activity.
Department of Pharmacognosy, Collegium Medicum, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland. mfpodola@cyf-kr.edu.pl
Irma
I
Podolak
Zbigniew
Z
Janeczko
Agnieszka
A
Galanty
Marta
M
Michalik
Danuta
D
Trojanowska
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots; D029623:Primulaceae / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
C524508:3-O-(beta-D-xylopyranosyl-(1-2)-beta-D-glucopyranosyl-(1-4)-(beta-D-glucopyranosyl-(1-2))-alpha-L-arabinopyranosyl)cyclamiretin A; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; D009828:Oleanolic Acid