EDOTn and MIM, new peptide backbone protecting groups.
In recent years, backbone protection has allowed the synthesis of complex peptidic sequences of high interest by preventing chain aggregation and aspartimides formation. Nevertheless, the backbone protectors currently used have some drawbacks: they are difficult to remove and show high steric hindrance. The new backbone protectors presented in this study (EDOTn and MIM) represent an improvement in both aspects.
Isidro-Llobet
Albert
A
Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Josep Samitier 1, 08028-Barcelona, Spain.
Just-Baringo
Xavier
X
Alvarez
Mercedes
M
Albericio
Fernando
F
D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
D019086:Bridged Bicyclo Compounds, Heterocyclic; D007211:Indoles; D010455:Peptides; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene); D001224:Aspartic Acid; C075871:aspartimide