Sirolimus-eluting stents. (The results of the five-year use for the treatment of coronary artery disease).
This paper discusses the results of the five-year clinical trials of sirolimus-eluting stents in the treatment of coronary artery disease. Analyzes outcomes of revascularization of the coronary arteries in patients with single focal lesions of the coronal arteries, multi-vessel coronary stenoses, chronic occlusion of the coronary arteries, bifurcation stenoses, and diabetes mellitus. Reviews the results of the use of sirolimus-eluting stents for the treatment of in-stent restenoses. Discusses the mechanism of antiproliferative action of rapamycin.
State Establishment Research Institute of Cardiology, Tomsk Scientific Center, Siberian Branch, RAMS, Tomsk, Russia. maslov@cardio.tsu.ru
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Krylov
D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D049109:Cell Proliferation / Q000187:drug effects; D020099:Coated Materials, Biocompatible; D003324:Coronary Artery Disease / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D009204:Myocardial Revascularization / Q000379:methods*; D020123:Sirolimus / Q000494:pharmacology*; D015607:Stents; D016896:Treatment Outcome
D020099:Coated Materials, Biocompatible; D007166:Immunosuppressive Agents; D020123:Sirolimus