Significance of inhibin B and anti-Müllerian hormone in seminal plasma: a preliminary study.
OBJECTIVE
To evaluate the predictive value of seminal inhibin B and anti-Müllerian hormone (AMH) on the outcome of testicular sperm extraction (TESE) in patients with nonobstructive azoospermia.


METHODS
Prospective study.


METHODS
Reproductive biology department.


METHODS
Forty-seven normospermic, 28 oligozoospermic, and 68 azoospermic patients.


METHODS
Testicular sperm extraction.


METHODS
Seminal inhibin B and AMH measure.


RESULTS
The seminal values of inhibin B and AMH are widely dispersed. Both inhibin B and AMH seminal values are significantly different between the three groups. The average rates of seminal AMH (not inhibin B) differ significantly according to the etiology of the azoospermia. Both seminal markers are correlated. A significant positive correlation could be observed between the seminal inhibin B and the sperm count, but not for AMH. A significant correlation also exists between seminal and serum inhibin B. The predictive value for TESE outcome of each parameter is rather low. Conversely, a logistic regression combining serum FSH, seminal inhibin B, and AMH produced a satisfying area under the curve of 0.985.


CONCLUSIONS
Seminal inhibin B and AMH values are proposed. Separately, seminal markers are poor predictors of TESE outcome. A logistic regression model led to a satisfying area under the curve of 0.985.
Laboratoire de Biologie de la Reproduction, Hôpital Nord, CHU de Saint Etienne, Saint Etienne, France.
Emma
E
Duvilla
Hervé
H
Lejeune
Béatrice
B
Trombert-Paviot
Anne
A
Gentil-Perret
Jacques
J
Tostain
Rachel
R
Levy
D000328:Adult; D054304:Anti-Mullerian Hormone / Q000032:analysis* / Q000378:metabolism / Q000502:physiology*; D053713:Azoospermia / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007265:Inhibins / Q000032:analysis* / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012661:Semen / Q000737:chemistry* / Q000378:metabolism; D053625:Sperm Retrieval; D016896:Treatment Outcome
C422364:inhibin B; D007265:Inhibins; D054304:Anti-Mullerian Hormone