[Study on drug release in vitro and rat intestinal absorption of resveratrol nanoliposomes].
OBJECTIVE
To study the release feature of Res-nanoliposomes in vitro and clarify the difference in absorption of Res-nanoliposomes from varied intestinal segments and the absorptive mechanism in vivo.


METHODS
Dialytic method was used to determine resveratrol release rate of Res-nanoliposomes in vitro. An in situ rat perfusion method was used to investigate the intestinal absorption of Res-nanoliposomes.


RESULTS
Resveratrol release from nanoliposomes in vitro fitted the log-normal distribution equation and had a property of sustained release. Compared with other intestinal segments, significantly high percentage of Res-nanoliposomes was absorbed in ileum (P < 0.001). The absorption rate constants (ka) of Res-nanoliposomes in intestine were not significantly different.


CONCLUSIONS
Res-nanoliposomes could sustain to release drug in vitro. The absorption was a first-order process with the passive diffusion mechanism. The Res-nanoliposomes could promote the absorption of Res in rat small intestine.
Huaxi School of Pharmacy, Sichuan university, Chengdu 610041, China.
Xin-chun
XC
Wang
Shi-xiang
SX
Hou
Wen
W
Li
Xiao-ying
XY
Li
Ya-wei
YW
Zhou
D000284:Administration, Oral; D000818:Animals; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D045468:Fallopia japonica / Q000737:chemistry; D007082:Ileum / Q000378:metabolism*; D007408:Intestinal Absorption; D008081:Liposomes; D008297:Male; D053758:Nanoparticles; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D008081:Liposomes; D013267:Stilbenes; D000077185:Resveratrol