[Morphological analysis of genetically damaged thyrocytes in nodular pathology of the thyroid gland].
The smears of isolated thyrocytes with micronuclei taken from 25 patients with nodular pathology of the thyroid gland were investigated. In all kinds of benign nodular pathology the number of micronucleated thyrocytes comes to 0.1-0.3%. These values correspond to the spontaneous level of the content of aberrant thyrocytes in the thyroid gland of highly specialized cell populations. In papillary carcinoma of the thyroid gland the average occurrence of micronucleated thyrocytes in the tumor nodule was about 0.4%. In the tissue outside the tumor taken from both the same and the opposite lobes, the content of cells with micronuclei proved to be substantially higher--0.93-1%. So, the marked increase of the concentration of genetically damaged cells in the thyroid parenchyma proved to be characteristic of the carcinoma of the thyroid gland.
Pavlov
A V
AV
Aleksandrov
Iu K
IuK
Beliakov
I E
IE
Korableva
T V
TV
D000236:Adenoma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D015162:Micronucleus Tests; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology*; D016606:Thyroid Nodule / Q000235:genetics* / Q000473:pathology*