Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications.
There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.
Department of Molecular Virology, Immunology and Medical Genetics, Colleges of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA.
George A
GA
Calin
Carlo M
CM
Croce
D000818:Animals; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D040641:Quantitative Trait Loci
D035683:MicroRNAs