Rv1773 is a transcriptional repressor deleted from BCG-Pasteur.
Mycobacterium bovis Bacille Calmette-Guérin (BCG) is a live attenuated vaccine for the prevention of tuberculosis. Transcriptome comparison reveals dysregulated expression of two genes, Rv1774 and Rv1775, exclusively in the Pasteur strain of BCG. We show that these genes form a bicistronic operon regulated by Rv1773, a transcriptional repressor deleted during the in vitro evolution of BCG.
McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
David C
DC
Alexander
Marcel A
MA
Behr
D001500:BCG Vaccine / Q000235:genetics / Q000276:immunology*; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics*; D006801:Humans; D008156:Luciferases / Q000235:genetics; D049449:Luminescence; D009163:Mycobacterium bovis / Q000235:genetics* / Q000276:immunology; D013045:Species Specificity; D014376:Tuberculosis / Q000517:prevention & control*; D014774:Virulence / Q000235:genetics* / Q000276:immunology
D001500:BCG Vaccine; D008156:Luciferases