Oxygen producing biomaterials for tissue regeneration.
A limiting factor in regenerating large organs and healing large wounds completely is the inability to provide oxygen to the affected areas for vascularization and healing to occur. An oxygen rich compound of sodium percarbonate was incorporated into films of Poly(D,L-lactide-co-glycolide) (PLGA) and used for in situ production of oxygen. Oxygen release could be observed from the film over a period of 24 h. When the oxygen producing biomaterials were placed in contact with ischemic tissue in a mouse model, decreased tissue necrosis and cellular apoptosis was observed. This indicates that improved tissue viability could be maintained for several days using oxygen producing biomaterials.
Harrison
Benjamin S
BS
Wake Forest Institute for Regenerative Medicine, Wake Forest University, Medical Center Boulevard, Winston-Salem, NC 27157, USA. bharriso@wfubmc.edu
Eberli
Daniel
D
Lee
Sang Jin
SJ
Atala
Anthony
A
Yoo
James J
JJ
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D008819:Mice, Nude; D010100:Oxygen / Q000737:chemistry* / Q000494:pharmacology*; D012038:Regeneration / Q000187:drug effects*; D023822:Tissue Engineering / Q000379:methods; D014945:Wound Healing / Q000187:drug effects*
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D010100:Oxygen