Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring.
Division of Molecular Therapeutics, KRIBB, Daejeon 305-806, Korea.
Woncheol
W
Kim
Jong Suk
JS
Lee
Dongho
D
Lee
Xing Fu
XF
Cai
Jin Chul
JC
Shin
Kyeong
K
Lee
Choong-Hwan
CH
Lee
Sangryeol
S
Ryu
Sang-Gi
SG
Paik
Jung Joon
JJ
Lee
Young-Soo
YS
Hong
D039903:Actinobacteria / Q000737:chemistry / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000235:genetics* / Q000378:metabolism; D016227:Benzoquinones / Q000737:chemistry* / Q000378:metabolism*; D002384:Catalysis; D002853:Chromatography, Liquid; D004791:Enzyme Inhibitors / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D006836:Hydro-Lyases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D047029:Lactams, Macrocyclic / Q000378:metabolism*; D013058:Mass Spectrometry; D008968:Molecular Conformation; D009154:Mutation / Q000235:genetics*; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism
D016227:Benzoquinones; D004791:Enzyme Inhibitors; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; C004532:quinone; C111160:3-amino-5-hydroxybenzoic acid synthase; D006836:Hydro-Lyases; D000262:Adenylyl Cyclases; C100622:adenylyl cyclase 2; C001277:geldanamycin