HDAC6-pack: cortactin acetylation joins the brew.
The reversible acetylation of lysine residues is an important posttranslational modification for the regulation of histones, transcription factors, chaperones, and microtubules. In a recent article in Molecular Cell, Zhang et al. (2007) describe a new target of reversible acetylation, the actin binding protein cortactin.
Department of Anatomy, Columbia University, New York, NY 10032, USA.
G W Gant
GW
Luxton
Gregg G
GG
Gundersen
D000107:Acetylation; D002465:Cell Movement; D051356:Cortactin / Q000737:chemistry / Q000378:metabolism*; D006655:Histone Deacetylases / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D013379:Substrate Specificity
D051356:Cortactin; D006655:Histone Deacetylases; D008239:Lysine