[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy].
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin. Some authors have pointed out an increased risk of TEN/SJS when phenytoin is associated with whole brain radiotherapy. We report a patient diagnosed with breast adenocarcinoma and brain metastases that was on treatment with phenytoin and, shortly after receiving whole brain radiotherapy, developed toxic epidermal necrolysis.
Fernández
F A
FA
Servicio de Medicina Interna, Hospital La Moraleja-Sanitas, Alcobendas, Madrid, España.
Pintor
E
E
Quesada
R
R
Garcés
F J
FJ
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000556:secondary; D001943:Breast Neoplasms / Q000601:surgery; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D015409:Mastectomy, Radical; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000209:etiology*
D000927:Anticonvulsants; D010672:Phenytoin; D003907:Dexamethasone; D009853:Omeprazole