Histological comparison of implanted cadaveric and porcine dermal matrix grafts.
OBJECTIVE
Histological comparison of human-based (AlloDerm) and porcine-based (ENDURAGen) dermal matrices regarding tissue incorporation and neovascularization as potential soft tissue augmentation materials.


METHODS
In vivo, rat model.


METHODS
Subcutaneous implantation of 1-mm thick, 1 cm x 1 cm pieces of AlloDerm, ENDURAGen, and meshed ENDURAGen was performed in 24 Sprague Dawley rats. Implant materials were harvested at 4 (n = 12) and 8 weeks (n = 12). Histological quantification of soft tissue ingrowth and microvascular density was performed following hematoxylin-eosin staining and CD34 immunohistochemistry, respectively.


RESULTS
AlloDerm showed significantly greater soft tissue ingrowth and microvascular density compared with both ENDURAGen and meshed ENDURAGen at 4 and 8 weeks (P < 0.001).


CONCLUSIONS
Although these results may differ in human host tissues, AlloDerm seems to be a more suitable dermal matrix implant than ENDURAGen for cases in which tissue incorporation and neovascularization are sought for the optimal outcome based on this animal model.
Richter
Gresham T
GT
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Smith
Jacob E
JE
Spencer
Horace J
HJ
Fan
Chun Y
CY
Vural
Emre
E
D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D003094:Collagen; D006085:Graft Survival; D006801:Humans; D008297:Male; D018919:Neovascularization, Physiologic; D010784:Photomicrography; D051381:Rats; D017207:Rats, Sprague-Dawley; D019651:Plastic Surgery Procedures / Q000379:methods*; D016038:Skin Transplantation / Q000379:methods / Q000473:pathology; D017768:Skin, Artificial; D018709:Statistics, Nonparametric; D013552:Swine
C440568:Alloderm; D001672:Biocompatible Materials; D003094:Collagen