HLA-A*68020103 shows an eight nucleotides deletion within intron 2 but has normal mRNA splicing and serological recognition.
A novel A*68020103 allele was completely characterized by sequencing in a Spanish bone marrow donor. A*68020103 has an eight nucleotides deletion at the 5'-end of intron 2, when compared with other A*6802 alleles. This alteration does not affect either its mRNA splicing process or serological detection.
Balas
A
A
Departamento de Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, Avenida de la Democracia s/n, 28032 Madrid, Spain. abalas.trans@salud.madrid.org
Sánchez-García
F
F
Bustamante
L
L
García-Sánchez
F
F
Vicario
J L
JL
D001483:Base Sequence; D015234:HLA-A Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D022821:RNA Splice Sites / Q000235:genetics*; D017384:Sequence Deletion
D015234:HLA-A Antigens; C519805:HLA-A*68:02:01:02 antigen; D022821:RNA Splice Sites