Glycomics-driven discoveries in schistosome research.
Schistosome glycans and glycoconjugates play a prominent role in the parasite's biology, in particular in the interaction with the human host. A large amount of structural data regarding glycosylation of different schistosome life stages and glycoconjugate subsets has been collected in the last decade, but many significant gaps in our knowledge of the schistosomal glycome remain. Here we will present a concise review of the already available data guided by a selection of recently generated stage-specific glycan profiles, and discuss implications and prospects of glycomics studies of schistosomes.
Hokke
Cornelis H
CH
Department of Parasitology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. c.h.hokke@lumc.nl
Deelder
André M
AM
Hoffmann
Karl F
KF
Wuhrer
Manfred
M
D000818:Animals; D002240:Carbohydrate Sequence; D006017:Glycolipids / Q000737:chemistry / Q000502:physiology*; D054794:Glycomics / Q000639:trends; D006023:Glycoproteins / Q000737:chemistry / Q000502:physiology*; D006031:Glycosylation; D006790:Host-Parasite Interactions; D006801:Humans; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000737:chemistry / Q000502:physiology*; D012547:Schistosoma / Q000737:chemistry / Q000502:physiology*; D012552:Schistosomiasis / Q000469:parasitology*
D006017:Glycolipids; D006023:Glycoproteins; D011134:Polysaccharides