Preparation of an extended-release matrix tablet using chitosan/Carbopol interpolymer complex.
A chitosan and Carbopol interpolymer complex (IPC) was formed using a precipitation method in an acidic solution. The chitosan and Carbopol IPC was characterized by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), and turbidity measurements. FT-IR demonstrated that the IPC formed a complex through an electrostatic interaction between the protonated amine (NH(3)(+)) group of chitosan and the carboxylate (COO(-)) group of Carbopol. DSC indicated the IPC to have different thermal characteristics from chitosan or Carbopol. The turbidity measurement revealed the complexation ratio of IPC between chitosan/Carbopol to be 1/4. A theophylline tablet was prepared using the IPC as a matrix material. The drug release profile from this tablet was similar to that from the HPMC tablet and showed a pH-independent release profile. The mechanisms for drug release from the IPC tablet were diffusional release at pH 6.8 and relaxational release at pH 1.2.
BK21 Project Team, College of Pharmacy, Chosun University, 375 Seosuk-dong, Gwangju 501-759, Republic of Korea.
Sung-Hyun
SH
Park
Myung-Kwan
MK
Chun
Hoo-Kyun
HK
Choi
D000179:Acrylates / Q000737:chemistry*; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D005079:Excipients / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D008970:Molecular Weight; D009391:Nephelometry and Turbidimetry; D011108:Polymers / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D013806:Theophylline / Q000737:chemistry / Q000493:pharmacokinetics; D014867:Water / Q000737:chemistry
D000179:Acrylates; D003692:Delayed-Action Preparations; D005079:Excipients; D011108:Polymers; D013607:Tablets; C492577:carbopol 971P; D014867:Water; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D048271:Chitosan; D013806:Theophylline