Decreased interleukin-1beta and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis.
BACKGROUND
The primary aim of this study was to compare the inflammatory activity in the gingival crevicular fluid (GCF) in a group of patients with rheumatoid arthritis (RA) and a group of matched controls. Secondarily, we aimed to evaluate the effect of rheumatologic treatment on periodontal inflammation.


METHODS
Seventeen individuals with RA with a mean duration of disease of 12.1 (+/- 9.9) years and the same number of systemically healthy individuals matched for age, gender, periodontal status, and tobacco use were selected. Medication data were registered, and GCF was collected by means of an intracrevicular washing method. Besides clinical registrations, periodontal inflammation was assessed by analysis of the cytokines interleukin (IL)-1beta and -18 and of elastase activity.


RESULTS
Amounts of IL-1beta and total elastase were significantly lower in the patient group. IL-1beta and total elastase had a significant and strong correlation in the RA group (r(s) = 0.883). This correlation was not observed in the control group.


CONCLUSIONS
The anti-inflammatory treatment taken by RA patients might influence the periodontal inflammation status represented by IL-1beta and elastase in the GCF.
Miranda
Letícia A
LA
Institute of Odontology, Division of Periodontology, Karolinska Institute, Huddinge, Sweden. leticia.miranda@ki.se
Islabão
Alexandre G
AG
Fischer
Ricardo G
RG
Figueredo
Carlos M S
CM
Oppermann
Rui V
RV
Gustafsson
Anders
A
D000082:Acetaminophen / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003774:Dental Plaque Index; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry* / Q000201:enzymology / Q000276:immunology; D005884:Gingival Hemorrhage / Q000145:classification; D006801:Humans; D020382:Interleukin-18 / Q000032:analysis; D053583:Interleukin-1beta / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000032:analysis*; D017622:Periodontal Attachment Loss / Q000145:classification; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D010518:Periodontitis / Q000145:classification; D011241:Prednisone / Q000627:therapeutic use; D012907:Smoking
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D020382:Interleukin-18; D053583:Interleukin-1beta; D000082:Acetaminophen; D010196:Pancreatic Elastase; D011241:Prednisone