Sleep-wake cycle disturbances in protein-energy malnutrition: effect of nutritional rehabilitation.
A standard sleep questionnaire was given to the parents of 26 infants with protein-energy malnutrition who underwent polysomnographic evaluation. These investigations were repeated approximately 2 months after enrolment in a nutritional rehabilitation programme based on World Health Organization guidelines. Anthropometric values and serum serotonin levels were also measured. After nutritional rehabilitation there was a significantly higher percentage of non-rapid eye movement (REM) sleep; 2nd REM time, and latency times for sleep and REM sleep increased. Percentages of REM sleep and serum serotonin levels decreased significantly. Protein-energy malnutrition seems to affect the sleep-wake cycle; disturbed serotonin levels may be among the factors responsible.
Shaaban
S Y
SY
Department of Paediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ei-Sayed
H L
HL
Nassar
M F
MF
Asaad
T
T
Gomaa
S M
SM
D000886:Anthropometry; D001827:Body Height; D001835:Body Weight; D016022:Case-Control Studies; D002648:Child; D004487:Edema / Q000209:etiology; D004534:Egypt; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000150:complications* / Q000175:diagnosis / Q000534:rehabilitation*; D015596:Nutrition Assessment; D018529:Nutritional Support; D017286:Polysomnography; D017410:Practice Guidelines as Topic; D011502:Protein-Energy Malnutrition / Q000150:complications* / Q000175:diagnosis / Q000534:rehabilitation*; D020923:REM Sleep Parasomnias / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D012701:Serotonin / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism; D020178:Sleep Disorders, Circadian Rhythm / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires
D006454:Hemoglobins; D012709:Serum Albumin; D012701:Serotonin