Video-electrographic and clinical features in patients with ictal asystole.
OBJECTIVE
Ictal asystole (IA) is a rare event mostly seen in patients with temporal lobe epilepsy (TLE) and a potential contributor to sudden unexplained death in epilepsy (SUDEP). Clinical and video-electroencephalographic findings associated with IA have not been described, and may be helpful in screening for high risk patients.


METHODS
A database search was performed of 6,825 patients undergoing long-term video-EEG monitoring for episodes of IA.


RESULTS
IA was recorded in 0.27% of all patients with epilepsy, eight with temporal (TLE), two with extratemporal (XTLE), and none with generalized epilepsy. In 8 out of 16 recorded events, all occurring in patients with TLE, seizures were associated with a sudden atonia on average 42 seconds into the typical semiology of a complex partial seizure. The loss of tone followed after a period of asystole usually lasting longer than 8 seconds and was associated with typical EEG changes seen otherwise with cerebral hypoperfusion. Clinical predisposing factors for IA including cardiovascular risk factors or baseline ECG abnormalities were not identified.


CONCLUSIONS
Ictal asystole is a rare feature of patients with focal epilepsy. Delayed loss of tone is distinctly uncommon in patients with temporal lobe seizures, but may inevitably occur in patients with ictal asystole after a critical duration of cardiac arrest and cerebral hypoperfusion. Further cardiac monitoring in patients with temporal lobe epilepsy and a history of unexpected collapse and falls late in the course of a typical seizure may be warranted and can potentially help to prevent sudden unexplained death in epilepsy.
Schuele
S U
SU
Cleveland Clinic, Cleveland, OH, USA. s-schuele@northwestern.edu
Bermeo
A C
AC
Alexopoulos
A V
AV
Locatelli
E R
ER
Burgess
R C
RC
Dinner
D S
DS
Foldvary-Schaefer
N
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D017776:Autonomic Pathways / Q000503:physiopathology; D001919:Bradycardia / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D001921:Brain / Q000033:anatomy & histology / Q000503:physiopathology; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D002675:Child, Preschool; D016757:Death, Sudden, Cardiac / Q000209:etiology* / Q000517:prevention & control; D042241:Early Diagnosis; D004568:Electrodiagnosis / Q000379:methods* / Q000592:standards / Q000639:trends; D004569:Electroencephalography / Q000379:methods / Q000592:standards / Q000639:trends; D004827:Epilepsy / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D004829:Epilepsy, Generalized / Q000209:etiology / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006323:Heart Arrest / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods / Q000592:standards; D011237:Predictive Value of Tests; D013575:Syncope / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D014741:Video Recording / Q000379:methods / Q000592:standards / Q000639:trends