Model for Osteosarcoma-9 as a potent factor in cell survival and resistance to apoptosis.
In this paper we use a simple model to explore the function of the gene Osteosarcoma-9 (OS-9). We are particularly interested in understanding the role of this gene as a potent anti-apoptotic factor. The theoretical description is constrained by experimental data from induction of apoptosis in cells where OS-9 is overexpressed. The data available suggest that OS-9 promotes cell viability and confers resistance to apoptosis, potentially implicating OS-9 in the survival of cancer cells. Three different apoptosis-inducing mechanisms were tested and are modeled here. A more complex and realistic model is also discussed.
Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, 115 21 Athens, Greece.
Ekaterini
E
Vourvouhaki
Carla
C
Carvalho
Paulo
P
Aguiar
D017209:Apoptosis / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D003198:Computer Simulation; D037102:Lectins; D008954:Models, Biological; D008956:Models, Chemical; D009363:Neoplasm Proteins / Q000737:chemistry* / Q000378:metabolism*
D037102:Lectins; D009363:Neoplasm Proteins; C098898:OS9 protein, human