EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses.
Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response. These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses.
Lazarus
Michael
M
Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
Yoshida
Kyoko
K
Coppari
Roberto
R
Bass
Caroline E
CE
Mochizuki
Takatoshi
T
Lowell
Bradford B
BB
Saper
Clifford B
CB
D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D015232:Dinoprostone / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D049452:Green Fluorescent Proteins / Q000378:metabolism; D017403:In Situ Hybridization / Q000379:methods; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011301:Preoptic Area / Q000166:cytology / Q000502:physiology*; D018078:Receptors, Prostaglandin E / Q000172:deficiency / Q000378:metabolism*; D058308:Receptors, Prostaglandin E, EP3 Subtype; D013997:Time Factors
C545648:Ptger3 protein, mouse; D018078:Receptors, Prostaglandin E; D058308:Receptors, Prostaglandin E, EP3 Subtype; D049452:Green Fluorescent Proteins; D015232:Dinoprostone