Question 6: early steps of evolution and some ideas about a simplified translational machinery.
Here, the undisputed steps in the beginning of life on earth are compiled, before a retrograde approach is presented outlining a possible minimal set of components required for protein synthesis, based on our knowledge of modern translational apparatus of Escherichia coli.
Max-Planck-Institut für Molekulare Genetik, AG Ribosomen, Ihnestr. 73, 14195 Berlin, Germany. nierhaus@molgen.mpg.de
Knud H
KH
Nierhaus
D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D005075:Biological Evolution; D004734:Energy Metabolism; D005815:Genetic Code; D000069497:Origin of Life; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012335:RNA, Ribosomal; D012343:RNA, Transfer; D012269:Ribosomal Proteins / Q000378:metabolism
D011506:Proteins; D012335:RNA, Ribosomal; D012269:Ribosomal Proteins; D012343:RNA, Transfer