Correlation between P53 expression and CD34 angiogenic factor in Tunisian breast cancer.
BACKGROUND
Angiogenesis is a significant prognostic factor in breast cancer, but the factors that control angiogenesis in vivo are not well defined.


OBJECTIVE
The purpose of this study was to investigate P53 expression in breast cancer and to examine the relationship between P53 overexpression and the degree of angiogenesis.


METHODS
A total of 52 paraffin-embedded tumors were evaluated immunohistochemically for expression of P53 and CD34 angiogenesis factor.


RESULTS
The majority of P53 positive cases (82%) demonstrated high level of microvessel density (MVD); 18% demonstrated no CD 34 expression. In contrast there was no variation of CD34 expression among P53 negative tumors.


CONCLUSIONS
This data suggests that microvessel density is promoted by P53 overexpression in breast cancer, and is correlated with high histologic grade.
Institut Salah Azaiez , Place Bab Saadoun, Tunis.
Asma
A
Fourati
Fathi
F
Khomsi
Michele V
MV
El May
Khaled
K
Rahal
Amor
A
Gamoudi
Hamouda
H
Boussen
Mansour
M
Ben Abdallah
Ahmed
A
El May
D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D001943:Breast Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D011446:Prospective Studies; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D018952:Antigens, CD34; D016159:Tumor Suppressor Protein p53