Cell type-specific gating of perisomatic inhibition by cholecystokinin.
Parvalbumin- and cholecystokinin (CCK)-expressing basket cells provide two parallel, functionally distinct sources of perisomatic inhibition to postsynaptic cells. We show that exogenously applied CCK enhances the output from rat parvalbumin-expressing basket cells, while concurrently suppressing GABA release from CCK-expressing neurons through retrograde endocannabinoid action. These results indicate that CCK may act as a molecular switch that determines the source of perisomatic inhibition for hippocampal principal cells.
Department of Anatomy and Neurobiology, University of California, Irvine, California 92697-1280, USA. cfoldy@uci.edu
Csaba
C
Földy
Soo Yeun
SY
Lee
János
J
Szabadics
Axel
A
Neu
Ivan
I
Soltesz
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002766:Cholecystokinin / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006624:Hippocampus / Q000166:cytology; D006727:Hormone Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D015640:Ion Channel Gating / Q000187:drug effects* / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects / Q000528:radiation effects; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000145:classification* / Q000187:drug effects* / Q000378:metabolism; D010320:Parvalbumins / Q000378:metabolism; D018408:Patch-Clamp Techniques / Q000379:methods; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D002121:Calcium Channel Blockers; D006727:Hormone Antagonists; D010320:Parvalbumins; D001569:Benzodiazepines; C087260:YM 022; D005680:gamma-Aminobutyric Acid; D002766:Cholecystokinin