[The modification and variants of histone].
The modification of histone plays a crucial role in regulating chromatin states that conserve transcription programs and provide a mechanism for chromatin states to be maintained as cells proliferate. A large number of factors and protein complexes are now known to be involved in regulating the dynamic states of the modification and variants of histone. A fraction of histones are nonallelic variants that have specific expression localization, and species-distribution patterns. Here we discuss recent progress in understanding how histone variants lead to changes in chromatin structure and dynamics to carry out specific functions.
Changjun
C
Mu
Heng
H
Liu
Guo-Chang
GC
Zheng
D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000502:physiology*; D006657:Histones / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008745:Methylation; D010766:Phosphorylation; D020033:Protein Isoforms / Q000378:metabolism / Q000502:physiology
D002843:Chromatin; D006657:Histones; D020033:Protein Isoforms