Metabolism of deltamethrin in rats.
OBJECTIVE
To study the metabolism of 14C-deltamethrin in rats.


METHODS
Rats were dosed orally and i.p. with a single dose of 14C-deltamethrin (0.64 mg/Kg) body weight. The required dose was applied daily for 3 days. At the end of the experiment, selected organs, such as liver, kidney, fat, intestine, and blood were excised for radioassay of 14C-content.


RESULTS
Deltamethrin was almost eliminated from the body within 1-3 days. The main portion of 14C-residues was extracted from urine (38%, 32%) and feces (20%, 24%) with a little amount remained in various organs.


CONCLUSIONS
The elimination and distribution of 14C-radioactivity in rats treated orally and intraperitoneally signify that deltamethrin is bioavailable in urine and feces.
Department of Applied Organic Chemistry National Research Centre, Dokki, Cairo, Egypt. somiaibrahem@yahoo.com
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El-Maghraby
D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D008297:Male; D009570:Nitriles / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D011722:Pyrethrins / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin