[Incidence and reasons of premature discontinuation of abacavir: results of a hospital investigation among 628 patients].
OBJECTIVE
The aim of this study was to determine the incidence of abacavir discontinuation within the first two months of treatment and the link with a true hypersensitivity reaction (HSR).


METHODS
A retrospective study was made between January 1998 and January 2006 on a cohort of HIV positive patients treated by abacavir delivered by the Bordeaux Saint-André University Hospital pharmacy.


RESULTS
Six hundred (and) twenty-eight patients were included. The reasons for non-renewal of abacavir prescription within the first three months of treatment were investigated. Early discontinuation for adverse effects was reported in 32 patients (5.1%): proved diagnosis of HSR (N=10), uncertain diagnosis of HSR (N=8), and no HSR (N=14). The decision for discontinuation was taken by physician after consultation in 76% of cases.
Service de pharmacie, hôpital Saint-André, CHU de Bordeaux, 33000 Bordeaux, France. nadinefoucher@voila.fr
N
N
Foucher
M-C
MC
Pertusa
B
B
Lahille
N
N
Bernard
I
I
Louis
M
M
Bonarek
P
P
Morlat
J-P
JP
Pometan
D015224:Dideoxynucleosides / Q000009:adverse effects* / Q000627:therapeutic use*; D004342:Drug Hypersensitivity; D005334:Fever / Q000209:etiology; D005602:France; D005767:Gastrointestinal Diseases / Q000209:etiology; D015658:HIV Infections / Q000188:drug therapy*; D006785:Hospitals, University; D006801:Humans; D009140:Musculoskeletal Diseases / Q000209:etiology; D012189:Retrospective Studies; D000099227:Abacavir
D015224:Dideoxynucleosides; D000099227:Abacavir