[Cytotoxic derivatives of (22R,23R)-22,23-dihydroxystigmastane].
(22R,23R)-22,23-dihydroxystigmast-4-en-3-one, (22R,23R)-22,23-dihydroxystigmast-4-en-3,6-dione, (22R,23R)-3beta,5alpha,6beta,22,23-pentahydroxystigmastane, (22R,23R)-5alpha,6alpha-oxido-3beta,22,23-trihydroxystigmastane, (22R,23R)-5beta,6beta-oxido-3beta,22,23-trihydroxystigmastane, and (22R,23R)-3beta,6beta,22,23-tetrahydroxystigmast-4-ene were synthesized. Their cytotoxicities were comparatively studied using the MCF-7 line of carcinoma cells of human mammary gland and cells of human hepatoma of the Hep G2 line.
F V
FV
Drozdov
A R
AR
Mekhtiev
G E
GE
Morozevich
V P
VP
Timofeev
A Iu
AIu
Misharin
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013261:Sterols / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D013261:Sterols