[Tumor lysis syndrome].
Tumor lysis syndrome is a potentially life threatening oncologic emergency that requires immediate medical intervention. The syndrome results from the destruction (or lysis) of a large number of rapidly dividing malignant cells spontaneously or during chemotherapy. The resulting metabolic abnormalities include hyperkaliemia, hyperuricemia, and hyperphosphatemia with secondary hypocalcemia, all of which put patients at risk for renal failure and alteration in cardiac function. The tumor lysis syndrome occurs most often in patients with large tumor burdens that are very sensitive to chemotherapy and radiotherapy, such as acute or chronic leukaemias with high leukocyte counts and high-grade lymphoma. The current standard management for tumor lysis syndrome consists of allopurinol or recombinant urate oxidase for high risk patient in conjunction with i.v. hydratation with or without alkalinization.
Jeddi
Ramzi
R
Service d'hématologie clinique, Hopital Aziza othmana, Tunis.
Ben Abdennebi
Yosr
Y
Allani
Bassam
B
Belakhal
Raihane
R
Aissaoui
Lamia
L
Ben Abid
Hela
H
Ali
Zaher Belhadj
ZB
Meddeb
Balkis
B
D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D000493:Allopurinol / Q000627:therapeutic use; D000963:Antimetabolites / Q000627:therapeutic use; D005440:Fluid Therapy; D006801:Humans; D015275:Tumor Lysis Syndrome / Q000150:complications / Q000209:etiology* / Q000628:therapy*; D014883:Water-Electrolyte Imbalance / Q000209:etiology / Q000628:therapy
D000963:Antimetabolites; D000493:Allopurinol