Detection of Several Classes of Pesticides and Metabolites in Meconium by Gas Chromatography-Mass Spectrometry.
A solid phase extraction method was developed to isolate multiple classes of parent pesticides from meconium. A methanolic/hydrochloric acid methyl ester derivatization with liquid-liquid extraction technique was also developed for the analysis of metabolites. Identification and quantitation was by electron impact gas chromatography-mass spectrometry. For the parent compounds and metabolites, recoveries in spiked meconium ranged between 72-109%, with coefficients of variation ranging from 1.55-16.92% and limits of detection between 0.01-4.15 μg g(-1). Meconium samples obtained from infants in the Philippines were assayed using these methods, and propoxur, cypermethrin, pretilachlor, malathion, 4,4'-dichlorodiphenyltrichloroethylene, bioallethrin, and cyfluthrin were detected.
Bielawski
D
D
Department of Pediatrics, Wayne State University School of Medicine, 421 E. Canfield Blvd., Rm. 2245, 48201, MI, Detroit USA; E-Mail:  dbielaws@med.wagne.edu.
Ostrea
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E
Posecion
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N
Corrion
M
M
Seagraves
J
J