Influence of the type of cellulose on properties of multi-unit target releasing in stomach dosage form with verapamil hydrochloride.
Microcrystalline cellulose (MCC) and powdered cellulose (PC) are commonly used excipients for solid dosage forms e.g., pellets. The aim of this study was to compare the utility of the MCC and PC in the floating pellet cores comprising verapamil hydrochloride (VH) manufactured by extrusion and spheronization and influence on their physical properties like swelling, compressibility and VH release. It was found by scanning electron microscopy (SEM) investigation that porosity of surface of the pellets' cores increased with an increase of PC amount in composition. Differential scanning calorimetry (DSC) analysis indicated the lack of physicochemical interaction between PC and MCC either with VH or with any excipients in the pellet core. Formulation having the highest PC participation were characterized by the highest friability and compressibility and addition of MCC corresponded with a decrease of friability and compressibility. The results on pellets friability were not reflected by the results on the hardness test. It means that the PC contents growth contributes to the hardness growth. The swelling forces of physical mixture of powders containing PC and MCC was different and increased with increasing amount of PC in pellet's core. Pellets' cores were coated with Eudragit NE dispersion. It was found that VH release rate from coated pellets with higher amount of PC was considerably slower in comparison to the pellets containing highest MCC participation.
Department of Pharmaceutical Technology, Medical University of Gdańsk, 107 Gen. J. Hallera Str., 80-416 Gdańsk, Poland. wsawicki@amg.gda.pl
Wiesław
W
Sawicki
Rafał
R
Łunio
Olga
O
Walentynowicz
Jolanta
J
Kubasik-Juraniec
D002121:Calcium Channel Blockers / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005079:Excipients / Q000737:chemistry*; D006244:Hardness; D008855:Microscopy, Electron, Scanning; D011109:Polymethacrylic Acids / Q000737:chemistry; D016062:Porosity; D013607:Tablets; D014700:Verapamil / Q000737:chemistry*; D014783:Viscosity
D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; C496967:Eudragit NE40D; D005079:Excipients; D011109:Polymethacrylic Acids; D013607:Tablets; D002482:Cellulose; D014700:Verapamil; C109691:microcrystalline cellulose