Inhibition of pancreatic cancer cell growth.
Pancreatic cancer cells are resistant to the growth-inhibitory and apoptosis-inducing effects of conventional chemotherapeutic agents. There are multiple genetic and epigenetic events during the process of carcinogenesis that enable the cancer cells to avoid normal growth constraints and apoptosis. Investigation of the mechanisms involved has led to multiple strategies that encourage cell death and apoptosis to occur. The pathways involved are summarized in this review, together with some recently developed strategies to promote cell death in this cancer.
Adrian
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Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, POBox 17666, Al Ain, United Arab Emirates. tadrian@uaeu.ac.ae
D000970:Antineoplastic Agents / Q000494:pharmacology; D016923:Cell Death; D049109:Cell Proliferation / Q000187:drug effects*; D016503:Drug Delivery Systems; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D015398:Signal Transduction
D000970:Antineoplastic Agents