[Expression and clinical significance of KiSS-1 and E-cadherin in gastric cardia carcinoma].
OBJECTIVE
To investigate the expression and clinical significance of KiSS- 1 and E- cadherin in gastric cardia carcinoma and the correlation between the two proteins.


METHODS
The expression of KiSS- 1 and E- cadherin in 80 patients with gastric cardia carcinoma and 20 patients with normal gastric cardia epithelium was detected by immunohistochemical technique.


RESULTS
The expression of KiSS- 1 was negatively correlated with lymphatic metastasis and clinical stage (P < 0.05), but not correlated with the cancer differentiation (P < 0.05). The expression of E- cadherin was negatively correlated with lymphatic metastasis, clinical stage, and cancer differentiation (P < 0.05). Spearman test showed a positive correlation between KiSS- 1 and E- cadherin expression (r(s)=0.722, P < 0.05).


CONCLUSIONS
KiSS- 1 and E- cadherin may play important roles in inhibiting the invasion and metastasis of gastric cardia carcinoma.
Wang
Zhan-hui
ZH
Department of Oncology, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China.
Feng
Xiao-shan
XS
Wang
Gong-ping
GP
Gao
She-gan
SG
Mi
Jian-qiang
JQ
Sun
Jiang-Tao
JT
Qu
Zhi-feng
ZF
Han
Jing
J
Zhang
Luo
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000378:metabolism*; D002299:Cardia / Q000473:pathology; D005260:Female; D006801:Humans; D059648:Kisspeptins; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
D015820:Cadherins; C106628:KISS1 protein, human; D059648:Kisspeptins; D025521:Tumor Suppressor Proteins