Pathophysiology of early onset schizophrenia.
Early onset schizophrenia (with onset before adulthood) represents a rarer and possibly more severe form of the disorder which has received particular attention in the last two decades. Current evidence strongly suggest continuity with adult onset schizophrenia, with phenomenological, cognitive, genetic and neuroimaging data pointing towards similar neurobiological correlates and clinical deficits but worse long term outcome. Future research in early onset cases is likely to increase further our insight into the neurodevelopmental origins of schizophrenia and the complex gene-environment interactions affecting its emergence.
Kyriakopoulos
Marinos
M
Section of Neurobiology of Psychosis, Institute of Psychiatry, De Crespigny Park, King's College, London, UK.
Frangou
Sophia
S
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001921:Brain / Q000473:pathology*; D002648:Child; D006801:Humans; D015994:Incidence; D007802:Language; D011597:Psychomotor Performance; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012919:Social Behavior