Metastatic uterine leiomyosarcoma regression using an aromatase inhibitor.
BACKGROUND
Metastatic and disseminated uterine leiomyosarcoma has limited chemotherapeutic options.


METHODS
A 45-year-old nulligravida was originally diagnosed with a primary uterine leiomyosarcoma and treated with a total abdominal hysterectomy, followed by six courses of adjuvant platinum and doxorubicin chemotherapy. Three years later she developed multiple metastatic tumor nodules in the lungs. Because of the estrogen receptor positivity of the leiomyosarcoma by immunohistochemistry, she was treated with 1 mg of anastrozole daily. Progressive tumor regression was demonstrated by serial imaging in all metastatic lung tumor deposits, with an objective response lasting at least 12 months.


CONCLUSIONS
Uterine leiomyosarcoma metastatic to the lungs regressed with the use of the anastrozole aromatase inhibitor.
Hardman
Mary Pat
MP
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, USA.
Roman
Juan J
JJ
Burnett
Alexander F
AF
Santin
Alessandro D
AD
D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000556:secondary* / Q000628:therapy; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D009570:Nitriles / Q000627:therapeutic use*; D012074:Remission Induction; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000473:pathology* / Q000628:therapy
D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole