Hippomanin A from acetone extract of Phyllanthus urinaria inhibited HSV-2 but not HSV-1 infection in vitro.
Phyllanthus urinaria Linnea (Euphorbiaceae) is a commonly used traditional medicinal plant in oriental countries and has been reported to possess various biological activities. Previously, the acetone extract and some pure compounds from P. urinaria were found to suppress herpes simplex virus (HSV). In this study, another two pure compounds were isolated from acetone extract of P. urinaria and were tested for their in vitro anti-HSV-1 and HSV-2 activities. The results showed that hippomanin A impeded HSV-2 but not HSV-1 infection. Corilagin, however, inhibited neither HSV-1 nor HSV-2 replication. The similarity between corilagin and hippomanin A in structure, but difference in antiviral activity, therefore, merit further investigation.
Yang
Chien-Min
CM
Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan.
Cheng
Hua-Yew
HY
Lin
Ta-Chen
TC
Chiang
Lien-Chai
LC
Lin
Chun-Ching
CC
D000998:Antiviral Agents / Q000032:analysis / Q000494:pharmacology; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D047348:Hydrolyzable Tannins; D029803:Phyllanthus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
D000998:Antiviral Agents; D005960:Glucosides; D047348:Hydrolyzable Tannins; D010936:Plant Extracts; C527596:hippomanin A; C049096:corilagin