Effect of Usuhiratake (Pleurotus pulmonarius) on sneezing and nasal rubbing in BALB/c mice.
The anti-rhinitis properties of Pleurotus pulmonarius were investigated in BALB/c mice. A single administration of Pleurotus Pulmonarius caused no significant effect on antigen-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but a significant inhibition was observed after 2 weeks of repeated treatment at this dose, and at a dose of 200 mg/kg, it also caused a significant inhibition after repeated administration for 4 weeks. Pleurotus pulmonarius showed no significant inhibitory effect on the production of IgE. In addition, Pleurotus pulmonarius caused no inhibition of histamine-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but in vitro study, it inhibited histamine release from rat mast cells induced by compound 48/80 at the soluble supernatant solution of 30 and 100 microg/ml of Pleurotus pulmonarius suspended in PBS. These results demonstrated that Pleurotus pulmonarius may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan.
Rie
R
Yatsuzuka
Yoshiyuki
Y
Nakano
Shuishi
S
Jiang
Yuhki
Y
Ueda
Yuko
Y
Kishi
Yuh
Y
Suzuki
Emiko
E
Yokota
Ashequr
A
Rahman
Rie
R
Ono
Isato
I
Kohno
Chiaki
C
Kamei
D000818:Animals; D018926:Anti-Allergic Agents; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D007073:Immunoglobulin E / Q000378:metabolism; D007202:Indicators and Reagents; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D020076:Pleurotus / Q000737:chemistry*; D012220:Rhinitis / Q000188:drug therapy* / Q000523:psychology; D012912:Sneezing / Q000187:drug effects*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D018926:Anti-Allergic Agents; D007202:Indicators and Reagents; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine