Is the CD4 cell percentage a better marker of immunosuppression than the absolute CD4 cell count in HIV-infected patients with cirrhosis?
Recently, it was shown that cirrhotic patients without human immunodeficiency virus (HIV) infection had low CD4 cell counts and normal CD4 cell percentages, suggesting that, for HIV-infected persons, the CD4 cell percentage might be a more accurate marker of disease progression than the absolute CD4 cell count. In cirrhotic HIV-infected persons in the Italian Cohort of Antiretroviral-Naive Patients, the absolute CD4 cell count seemed to be better predictor of the risk of developing an acquired immunodeficiency syndrome-defining illness than the CD4 cell percentage.
Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy. marco.bongiovanni@unimi.it
Marco
M
Bongiovanni
Andrea
A
Gori
Alessandro Cozzi
AC
Lepri
Andrea
A
Antinori
Andrea
A
de Luca
Gabriella
G
Pagano
Alessandro
A
Chiodera
Massimo
M
Puoti
Antonella d'Arminio
Ad
Monforte
D015415:Biomarkers; D018791:CD4 Lymphocyte Count / Q000379:methods*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005355:Fibrosis / Q000150:complications*; D015658:HIV Infections / Q000150:complications* / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D011237:Predictive Value of Tests; D012306:Risk
D015415:Biomarkers