Right-hemisphere reading in a case of developmental deep dyslexia.
The right-hemisphere hypothesis of deep dyslexia has received support from functional imaging studies of acquired deep dyslexia following damage to the left cerebral hemisphere, but no imaging studies of cases of developmental deep dyslexia, in which brain damage is not suspected, have been reported. In this paper, we report the first evidence of right hyperactivation in an adult case of developmental deep dyslexia. Hyperactivation was observed in the right inferior frontal cortex during functional magnetic resonance imaging (fMRI) of the oral reading of imageable content words and nonwords to which imageable lexical responses were frequently made. No evidence of right hyperactivation was observed in the oral reading of function words, nor during the naming of imageable words in response to pictured objects. The results reveal strategic and selective use of right-hemisphere functions for particular types of written stimuli. We propose that children with developmental deep dyslexia compensate for their lack of phonological skills by accessing right-hemisphere imageable associations that provide a mnemonic for linking written forms to spoken names.
University of Nottingham, University Park, Nottingham, UK. nicola.pitchford@nottingham.ac.uk
Nicola J
NJ
Pitchford
Elaine
E
Funnell
Bianca
B
De Haan
Paul S
PS
Morgan
D000328:Adult; D001931:Brain Mapping; D004410:Dyslexia / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D011932:Reading; D014796:Visual Perception / Q000502:physiology*
D010100:Oxygen