Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil.
Multiple sclerosis (MS) is a multifactorial inflammatory disease that primarily affects the central nervous system. Genes and environmental factors probably interact in MS susceptibility and outcome; however, their roles have not been elucidated yet. The evaluation of the HLA-DRB1 gene in the Brazilian population is of particular interest in evidencing the behavior of HLA-DRB1 alleles in a highly admixed population inserted in an environment of low MS prevalence. The present results suggest that a given HLA-DRB1 allele may exhibit different behaviors, i.e. confer resistance or susceptibility, in response to the environmental and/or genetic (ethnic) backgrounds that characterize a sampled population.
Brum
Doralina Guimarães
DG
Department of Neurology, Medical School of Ribeirão Preto, University of São Paulo. Av. Bandeirantes, 3900, 14049-900, Ribeirão Preto, SP, Brazil.
Barreira
Amilton Antunes
AA
Louzada-Junior
Paulo
P
Mendes-Junior
Celso Teixeira
CT
Donadi
Eduardo Antônio
EA
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001938:Brazil / Q000208:ethnology; D002648:Child; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D044382:Population Groups
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains