A novel ketolide class: Synthesis and antibacterial activity of a lead compound.
Synthesis and antibacterial activity of a new class of ketolide antibiotics, exemplified by the prototype GW680788X (1), are described. The structure of (1) has been elucidated by spectroscopic analysis. The good antibacterial activity shown by (1) in comparison with clarithromycin prompted us to consider this compound as a lead molecule for further exploration.
GlaxoSmithKline, Medicine Research Centre, Via A Fleming 4, I-37135 Verona, Italy. daniele.g.andreotti@gsk.com
Daniele
D
Andreotti
Ilaria
I
Bientinesi
Stefano
S
Biondi
Daniele
D
Donati
Isabelle
I
Erbetti
Sergio
S
Lociuro
Carla
C
Marchioro
Alfonso
A
Pozzan
Emiliangelo
E
Ratti
Silvia
S
Terreni
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D048628:Ketolides / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular
D000900:Anti-Bacterial Agents; D048628:Ketolides