New TB vaccines: is there a requirement for CD8 T cells?
MHC class I-restricted CD8(+) T cells are necessary to mount an immune response against Mycobacterium tuberculosis. M. tuberculosis antigens can enter MHC class I cross-processing pathways through a number of different mechanisms, including via the uptake of antigen-containing apoptotic vesicles released by infected cells. A study in this issue of the JCI by Hinchey and colleagues shows that M. tuberculosis inhibits host cell apoptosis and thus may interfere with optimal cross-priming and action of CD8(+) T cells (see the related article beginning on page 2279). M. tuberculosis genetically modified to induce apoptosis is shown to be more effective in priming CD8(+) T cells in vivo and therefore may be a more effective vaccine against tuberculosis than the currently utilized M. bovis BCG vaccine.
Tuberculosis Research Unit, Case Western Reserve University and University Hospitals' Case Medical Center, Cleveland, Ohio 44106-4984, USA. whb@case.edu
W Henry
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Boom
D000251:Adenosine Triphosphatases / Q000172:deficiency; D000818:Animals; D001426:Bacterial Proteins; D002460:Cell Line; D017353:Gene Deletion; D006168:Guinea Pigs; D006801:Humans; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D026901:Membrane Transport Proteins / Q000172:deficiency; D051379:Mice; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D013482:Superoxide Dismutase / Q000235:genetics / Q000276:immunology; D014376:Tuberculosis / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control; D032581:Tuberculosis Vaccines / Q000235:genetics / Q000276:immunology*
D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D032581:Tuberculosis Vaccines; D013482:Superoxide Dismutase; D000251:Adenosine Triphosphatases; C442123:SecA2 protein, Mycobacterium