[Nutritional and antioxidant status of colorectal cancer patients].
BACKGROUND
Oxidative stress is one of the risk factors of colorectal carcinogenesis. In inflammatory reactions the activated leucocytes product mutagenic and mitogenic free radicals, hereby promoting tumor formation. Obesity, hyperlipidemia and hyperinsulinemia increases the energy supply of epithelial cells, thus leads to deregulation of mitochondrial electron transport chain. The latter leads to increased free radical production that causes troubles in cell cycle regulation, mutations, and unrestricted proliferation of damaged cells.


OBJECTIVE
Evaluation of some parameters of antioxidant and nutritional status in patients with benign or malignant colorectal neoplasm.


METHODS
Assessment of nutrient intake, measurement of some anthropometric parameters (body height, body weight, waist, hip and arm circumference, waist/hip ratio), determination of serum prealbumin level, evaluation of the biomarkers of antioxidant status (superoxide dismutase and glutathione peroxidase activity, levels of uric acid and albumin, total antioxidant status, free radical scavenger capacity), determination the concentration of oxidated product and malondialdehyde.


RESULTS
In patients with malignant tumor the dietary fiber, folate and vitamin A intake was under the optimal level, and the serum prealbumin concentration was lower than in patients with benign lesion. There was a high incidence of overweight and obesity among patients. Significant difference was found between diseased subjects and healthy controls in terms of the biomarkers of antioxidant status, such as free radical scavenger capacity, concentration of advanced oxidation protein products and malondialdehyde, glutathione peroxidase activity.


CONCLUSIONS
The insufficient folate and vitamin A intake, the high incidence of overweight and obesity, and the abnormal values of the biomarkers of antioxidant status observed in the study groups seem to support the correlation between colorectal tumor, nutritional and antioxidant status.
Országos Elelmiszerbiztonsági és Táplálkozástudományi Intézet, Budapest. regoly@oeti.antsz.hu
Andrea
A
Regöly-Mérei
Mihály
M
Bereczky
Györgyi
G
Arató
Géza
G
Telek
Zsolt
Z
Pallai
Andrea
A
Lugasi
Magda
M
Antal
D000236:Adenoma / Q000097:blood* / Q000378:metabolism; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D002277:Carcinoma / Q000097:blood* / Q000378:metabolism; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000378:metabolism; D004043:Dietary Fiber / Q000008:administration & dosage; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D016166:Free Radical Scavengers / Q000097:blood* / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009752:Nutritional Status; D009765:Obesity / Q000097:blood / Q000150:complications; D050177:Overweight; D011228:Prealbumin / Q000378:metabolism; D014801:Vitamin A / Q000008:administration & dosage
D000975:Antioxidants; D015415:Biomarkers; D004043:Dietary Fiber; D016166:Free Radical Scavengers; D011228:Prealbumin; D014801:Vitamin A; D008315:Malondialdehyde; D005492:Folic Acid; D005979:Glutathione Peroxidase