Is metabolic syndrome a risk factor for colorectal adenoma?
OBJECTIVE
Epidemiologic studies provide evidence for a link between obesity or diabetes and the risk for colorectal cancer. However, there is a lack of information about the relationship between metabolic syndrome and colorectal adenoma. Therefore, we investigated whether metabolic syndrome is a risk factor for colorectal adenoma.


METHODS
We did a study for consecutive subjects who underwent colonoscopy as a screening exam at the Center for Health Promotion, Samsung Medical Center, from March 2004 to December 2005. According to the modified ATP III criteria, metabolic syndrome was diagnosed. We classified a total of 2,531 subjects into the adenoma group (n = 731) and the control group (n = 1,800), including normal colonoscopic finding, nonpolyp benign lesions, or histologically confirmed hyperplastic polyp.


RESULTS
The prevalence for metabolic syndrome was 17% in the adenoma group and 11% in the control group. On the multiple logistic regression analyses, metabolic syndrome was found to be associated with an increased risk of colorectal adenoma (odds ratio, 1.51; 95% confidence interval, 1.18-1.93). Also, waist circumference among the individual components of metabolic syndrome was an independent risk factor for colorectal adenoma. An increased risk for metabolic syndrome was more evident for proximal than distal colon, for multiple (>/=3), and for advanced adenoma in the adenoma group.


CONCLUSIONS
Metabolic syndrome was associated with colorectal adenoma. Abdominal obesity of the individual components of metabolic syndrome was an important risk factor for colorectal adenoma.
Kim
Jeong Hwan
JH
Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine, Seoul 135-710, Korea.
Lim
Yun Jeong
YJ
Kim
Young-Ho
YH
Sung
In-Kyung
IK
Shim
Sang Goon
SG
Oh
Sung-Ook
SO
Park
Sin-Sil
SS
Yang
Sun
S
Son
Hee Jung
HJ
Rhee
Poong-Lyul
PL
Kim
Jae J
JJ
Rhee
Jong Chul
JC
Choi
Yoon-Ho
YH
D000236:Adenoma / Q000453:epidemiology*; D018253:Adenoma, Villous / Q000453:epidemiology; D000367:Age Factors; D000428:Alcohol Drinking / Q000453:epidemiology; D001837:Body Weights and Measures; D003110:Colonic Neoplasms / Q000453:epidemiology*; D003111:Colonic Polyps / Q000453:epidemiology; D003113:Colonoscopy; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006965:Hyperplasia; D006973:Hypertension / Q000453:epidemiology; D007723:Korea / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D011230:Precancerous Conditions / Q000453:epidemiology; D012004:Rectal Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology