Myocardial T1 mapping: application to patients with acute and chronic myocardial infarction.
T(1) maps obtained with modified Look-Locker inversion recovery (MOLLI) can be used to measure myocardial T(1). We aimed to evaluate the potential of MOLLI T(1) mapping for the assessment of acute and chronic myocardial infarction (MI). A total of 24 patients with a first MI underwent MRI within 8 days and after 6 months. T(1) mapping was performed at baseline and at selected intervals between 2-20 min following administration of gadopentetate dimeglumine (Gd-DTPA). Delayed-enhancement (DE) imaging served as the reference standard for delineation of the infarct zone. On T(1) maps the myocardial T(1) relaxation time was assessed in hyperenhanced areas, hypoenhanced infarct cores, and remote myocardium. The planimetric size of myocardial areas with standardized T(1) threshold values was measured. Acute and chronic MI exhibited different T(1) changes. Precontrast threshold T(1) maps detected segmental abnormalities caused by acute MI with 96% sensitivity and 91% specificity. Agreement between measurements of infarct size from T(1) mapping and DE imaging was higher in chronic than in acute infarcts. Precontrast T(1) maps enable the detection of acute MI. Acute and chronic MI show different patterns of T(1) changes. Standardized T(1) thresholds provide the potential to dichotomously identify areas of infarction.
BHF Cardiac MRI Unit, Leeds General Infirmary, Leeds, UK.|Cardiac MRI Unit, Franz Volhard Klinik, Charité/Humboldt Universität, Berlin, Germany.
Daniel R
DR
Messroghli
Division of Genomic Medicine, University of Sheffield, Sheffield, UK.
Kevin
K
Walters
BHF Cardiac MRI Unit, Leeds General Infirmary, Leeds, UK.
Sven
S
Plein
BHF Cardiac MRI Unit, Leeds General Infirmary, Leeds, UK.
Patrick
P
Sparrow
Department of Cardiac Sciences, Stephenson CMR Centre, University of Calgary, Calgary, Canada.|Department of Radiology, Stephenson CMR Centre, University of Calgary, Calgary, Canada.
Matthias G
MG
Friedrich
Department of Medical Physics, Leeds General Infirmary, Leeds, UK.
John P
JP
Ridgway
BHF Cardiac MRI Unit, Leeds General Infirmary, Leeds, UK.
Mohan U
MU
Sivananthan
D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D009206:Myocardium / Q000473:pathology