Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid.
Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.
Ogata
Masahiro
M
Aomori University, 2-3-1 Kohbata, Aomori 030-0943, Japan. ogata-ms@aomori-u.ac.jp
Oka
Kentaro
K
Seki
Masako
M
Hoshi
Midori
M
Takatsu
Hirokatsu
H
Mashino
Tadahiko
T
Urano
Shiro
S
Endo
Toyoshige
T
D000473:Alkanes / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000737:chemistry; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D005079:Excipients; D008826:Microbial Sensitivity Tests; D009005:Monosaccharides / Q000737:chemistry*; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects
D000473:Alkanes; D000900:Anti-Bacterial Agents; D005079:Excipients; D009005:Monosaccharides; D010636:Phenols; C504748:dipropofol; D001205:Ascorbic Acid