Ocular effects of exposure to industrial chemicals: clinical management and proteomic approaches to damage assessment.
Industrial chemicals in a variety of applications are often found in highly populated areas and their presence carries risks. The threat of serious consequences from inadvertent or intentional events involving hazardous chemicals is a possibility. Extremism and/or other illicit activities pose environmental threats from chemical exposures. We present here a review of the threat of ocular injury in small-and large-scale chemical releases and discuss mechanisms of damage and repair to the eyes. The emerging field of proteomics has been described in relation to its potential role in the assessment of ocular changes following chemical exposures and management of ocular trauma.
Bhattacharya
Sanjoy K
SK
Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA. SBhattacharya@med.miami.edu
Hom
Gregory G
GG
Fernandez
Christopher
C
Hom
Louis G
LG
D000062:Accidents, Occupational; D000143:Acids / Q000633:toxicity; D000468:Alkalies / Q000633:toxicity; D000641:Ammonia / Q000633:toxicity; D002057:Burns, Chemical / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D002619:Chemical Warfare Agents / Q000633:toxicity*; D017606:Chlorine Compounds / Q000633:toxicity; D004190:Disasters; D005123:Eye / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D005126:Eye Burns / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D005136:Eye Proteins / Q000378:metabolism; D015386:Hazardous Substances / Q000633:toxicity*; D006801:Humans; D017953:Isocyanates / Q000633:toxicity; D008466:Mechlorethamine / Q000633:toxicity; D009151:Mustard Gas / Q000633:toxicity; D011506:Proteins / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D018570:Risk Assessment; D014945:Wound Healing
D000143:Acids; D000468:Alkalies; D002619:Chemical Warfare Agents; D017606:Chlorine Compounds; D005136:Eye Proteins; D015386:Hazardous Substances; D017953:Isocyanates; D011506:Proteins; D008466:Mechlorethamine; D000641:Ammonia; C008461:methyl isocyanate; D009151:Mustard Gas