A 'Yang-Invigorating' Chinese herbal formula protects against gentamicin-induced nephrotoxicity in rats.
The effects of VI-28 (a Yang-invigorating Chinese herbal formula) treatment on the renal mitochondrial antioxidant system and susceptibility to gentamicin-induced nephrotoxicity were investigated in rats. VI-28 treatment (80 or 240 mg/kg/day x 12) enhanced the renal mitochondrial antioxidant system, as indicated by dose-dependent increases in the level/activities of reduced glutathione, Mn-superoxide dismutase, Se-glutathione peroxidase and glutathione S-transferases. VI-28 treatment protected against nephrotoxicity induced by gentamicin administration (100 mg/kg/day x 8) and the nephroprotection was associated with an enhancement in the renal mitochondrial antioxidant system. In conclusion, VI-28 treatment enhanced the renal mitochondrial antioxidant system, thereby protecting against gentamicin nephrotoxicity.
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China.
Michel K T
MK
Poon
P Y
PY
Chiu
H Y
HY
Leung
Ada H L
AH
Siu
K M
KM
Ko
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use*; D005839:Gentamicins; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008516:Medicine, Chinese Traditional; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D016711:Yang Deficiency / Q000188:drug therapy*
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005839:Gentamicins; C529538:VI-28 herbal formula; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione