Deoxyribonucleic acid-damaged sperm in cryopreserved-thawed specimens from cancer patients and healthy men.
A similarity was found between the percentage of thawed, DNA-damaged spermatozoa in cancer patients and that in candidates to become sperm bank donors who had low sperm cryofreezability. Both groups were significantly different from the sperm bank donor group. It is suggested that the higher rate of DNA fragmentation in sperm from cancer patients compared with sperm bank donors is apparently a result of selecting donors by the level of sperm cryofreezability (i.e., high), rather than a direct effect of an existing malignancy.
The Institute for the Study of Fertility, Lis Maternity Hospital, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Avital
A
Edelstein
Haim
H
Yavetz
Sandra E
SE
Kleiman
Amnon
A
Botchan
Ron
R
Hauser
Gedalia
G
Paz
Leah
L
Yogev
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002470:Cell Survival; D002499:Centrifugation, Density Gradient; D015925:Cryopreservation; D004249:DNA Damage; D006689:Hodgkin Disease / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008297:Male; D027724:Reproductive Techniques, Assisted; D012662:Semen Preservation; D013074:Sperm Banks; D013081:Sperm Motility; D013094:Spermatozoa / Q000473:pathology*; D013736:Testicular Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology