Endotoxin removal from albumin and saline solutions.
Microporous membranes have been developed which can remove endotoxins selectively from electrolyte and albumin solutions by regioselective adsorption in the membrane matrix and outside surface of the membrane. The membranes were prepared in the form of hollow fibre membranes in a continuous process. By varying the membrane preparation parameters, different pore sizes and adsorption capacities could be realized, thus broadening applications for biological purification. Dynamic adsorption capacities for endotoxin from albumin and saline solution were determined and were found to be in the range of 0.2 and 0.1 microg endotoxin/g membrane, respectively, suggesting different adsorption mechanisms.
Bell
C-M
CM
Institut für Angewandte Forschung, Hochschule Reutlingen, Fakultät für Angewandte Chemie, Reutlingen, Germany. carl-martin.bell@hochschule-reutlingen.de
Guo
K
K
Wendel
H P
HP
D000327:Adsorption; D004731:Endotoxins / Q000302:isolation & purification*; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D006435:Renal Dialysis; D012462:Saline Solution, Hypertonic; D012709:Serum Albumin
D004731:Endotoxins; D008567:Membranes, Artificial; D012462:Saline Solution, Hypertonic; D012709:Serum Albumin