Oxygen producing biomaterials for tissue regeneration.
A limiting factor in regenerating large organs and healing large wounds completely is the inability to provide oxygen to the affected areas for vascularization and healing to occur. An oxygen rich compound of sodium percarbonate was incorporated into films of Poly(D,L-lactide-co-glycolide) (PLGA) and used for in situ production of oxygen. Oxygen release could be observed from the film over a period of 24 h. When the oxygen producing biomaterials were placed in contact with ischemic tissue in a mouse model, decreased tissue necrosis and cellular apoptosis was observed. This indicates that improved tissue viability could be maintained for several days using oxygen producing biomaterials.
Wake Forest Institute for Regenerative Medicine, Wake Forest University, Medical Center Boulevard, Winston-Salem, NC 27157, USA. bharriso@wfubmc.edu
Benjamin S
BS
Harrison
Daniel
D
Eberli
Sang Jin
SJ
Lee
Anthony
A
Atala
James J
JJ
Yoo
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D008819:Mice, Nude; D010100:Oxygen / Q000737:chemistry* / Q000494:pharmacology*; D012038:Regeneration / Q000187:drug effects*; D023822:Tissue Engineering / Q000379:methods; D014945:Wound Healing / Q000187:drug effects*
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D010100:Oxygen