In vitro antibacterial activities of tigecycline and comparative agents by time-kill kinetic studies in fresh Mueller-Hinton broth.
Time-kill kinetics performed with tigecycline, in fresh MHB, demonstrated a consistent 1 to 2 log(10) CFU/ml reduction in bacterial counts against the majority of clinically relevant pathogens tested. Although classified as a bacteriostatic agent, tigecycline shows bactericidal activity against select isolates associated with serious infection. In general, vancomycin and imipenem demonstrated bactericidal activity.
Petersen
Peter J
PJ
Infectious Disease Discovery Research, Biological Technologies, Wyeth Research, Pearl River, NY 10965, USA. petersp@wyeth.com
Jones
C Hal
CH
Bradford
Patricia A
PA
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D003470:Culture Media; D024881:Drug Resistance, Bacterial; D016946:Gram-Negative Aerobic Rods and Cocci / Q000187:drug effects; D006095:Gram-Positive Cocci / Q000187:drug effects; D006801:Humans; D015378:Imipenem / Q000493:pharmacokinetics; D008826:Microbial Sensitivity Tests / Q000379:methods*; D008911:Minocycline / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000078304:Tigecycline; D014640:Vancomycin / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D003470:Culture Media; D014640:Vancomycin; D000078304:Tigecycline; D015378:Imipenem; D008911:Minocycline