Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin.
The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.
Institute for Clinical and Molecular Virology, University Hospital Erlangen, 91054 Erlangen, Germany.
Andrea
A
Marzi
Daniel A
DA
Mitchell
Chawaree
C
Chaipan
Tanja
T
Fisch
Robert W
RW
Doms
Mary
M
Carrington
Ronald C
RC
Desrosiers
Stefan
S
Pöhlmann
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002460:Cell Line; D006031:Glycosylation; D006678:HIV / Q000737:chemistry / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D015483:HIV Antibodies / Q000276:immunology*; D015658:HIV Infections / Q000635:transmission / Q000821:virology; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D037601:Mannose-Binding Lectin / Q000378:metabolism*; D009500:Neutralization Tests; D011134:Polysaccharides / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000635:transmission / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000737:chemistry / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D000914:Antibodies, Viral; D015815:Cell Adhesion Molecules; D015483:HIV Antibodies; D037181:Lectins, C-Type; D037601:Mannose-Binding Lectin; D011134:Polysaccharides; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin