[Hypoparathyroidism associated with autoimmune disorder].
Isolated and acquired hypoparathyroidism occurs as an autoimmune disorder either alone or in association with other autoimmune diseases. Reduced PTH (parathyroid hormone) secretion due to disorder of Ca-sensing regulation in parathyroid gland is most commonly caused by activating mutations of the CaSR (Ca-sensing receptor) gene. There has been accumulating evidence that it also occurs as a result of activating autoantibodies directed to CaSR. Hypoparathyroidism is one of the most common endocrine manifestation in APECED (Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy) , which is also known as APS (Autoimmune Polyendocrinopathy Syndrome) type I . In APECED, the spectrum of epitope responsible for the hypoparathyroidism is presumably CaSR. It remains unclear how autoimmunity against CaSR occurs and how much patients caused by this disorder exist.
Shimane University Faculty of Medicine, Internal Medicine 1, Japan.
Mika
M
Yamauchi
Toshitsugu
T
Sugimoto
D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000150:complications*; D002762:Cholecalciferol / Q000627:therapeutic use; D006801:Humans; D007011:Hypoparathyroidism / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016884:Polyendocrinopathies, Autoimmune / Q000175:diagnosis / Q000209:etiology; D044169:Receptors, Calcium-Sensing / Q000276:immunology*
D001323:Autoantibodies; D044169:Receptors, Calcium-Sensing; D002762:Cholecalciferol