[Dynamics of absorption of yellow fluorescent protein in intestine and reabsorption in kidney in rat postnatal ontogenesis].
In experiments of the 5, 12 and 25-day old rat pups and adult rats in has been shown that after administration of yellow fluorescent protein (YFP) into stomach, its partial absorption in the non-degraded state in the small intestine takes place, with subsequent transport to kidney with blood flow and accumulation in cells of the proximal nephron segment. With age of rats, intensity of the intestinal YFP absorption decrease; the YFP accumulation in the kidney is more active in rats of the younger age groups than in adult animals. No accumulation of YFP in liver was revealed. The obtained data indicate an intensive absorption of YFP in the non-hydrolyzed form in the rat pup small intestine in early postnatal ontogenesis and an important role of kidney in protein metabolism and in proteolysis of exogenous proteins.
Burmakin
M V
MV
Seliverstova
E V
EV
Natochin
Iu V
IuV
D000042:Absorption; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism* / Q000493:pharmacokinetics; D020895:Enterocytes / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism* / Q000648:ultrastructure; D007668:Kidney / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D008164:Luminescent Proteins / Q000378:metabolism* / Q000493:pharmacokinetics; D009399:Nephrons / Q000254:growth & development / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D001426:Bacterial Proteins; D008164:Luminescent Proteins; C054562:yellow fluorescent protein, Bacteria