[Effects of acupuncture promoting embryo implantation and development in the rat with dysfunctional embryo implantation].
OBJECTIVE
To explore effects of acupuncture on embryo implantation and development in the rat with dysfunctional embryo implantation.


METHODS
The pregnant rats were randomly divided into a control group, a model group and an acupuncture group. In the model group and the acupuncture group, the dysfunctional embryo implantation were developed by Mifepristone, and the acupuncture group were treated with acupuncture for one consecutive week fro the first day of pregnancy. The pregnant rate, the average embryo implantation number, weight of the uterus, ovary and the size and weight of single embryo were compared among the 3 groups, and optical microscope was used for comparison of the morphological structures of the endometrium and ovary were compared among the 3 groups.


RESULTS
In the acupuncture group, the pregnant rate, the average embryo implantation number were more significantly increased as compared with the model group (P < 0.01); in the model group, the weight of the uterus and ovary were lighter than those in the control group and the acupuncture group, with poor development of the endometrium in the model group, but development of the endometrium in the acupuncture group was similar to that in the control group.


CONCLUSIONS
Acupuncture can reverse Mifepristone's anti-implantation effect to a certain extent, and promote implantation and development of embryo in the rat.
Institute of Integrated Chinese Medicine and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Xin-yu
XY
Liu
Guang-ying
GY
Huang
Ming-min
MM
Zhang
D015670:Acupuncture Therapy; D000818:Animals; D010064:Embryo Implantation / Q000187:drug effects; D047108:Embryonic Development; D005260:Female; D015735:Mifepristone / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats
D015735:Mifepristone