OP-1/BMP-7 in cartilage repair.
Three years ago we published a book chapter on the role of bone morphogenetic proteins (BMPs) in cartilage repair. Since that time our understanding of the function of osteogenic protein-1 (OP-1) or BMP-7 in cartilage homeostasis and repair has substantially improved and therefore we decided to devote a current review solely to this BMP. Here we summarise the information accumulated on OP-1 from in vitro and ex vivo studies with cartilage cells and tissues as well as from in vivo studies of cartilage repair in various animal models. The primary focus is on articular chondrocytes and cartilage, but data will also be presented on nonarticular cartilage, particularly from the intervertebral disc. The data show that OP-1 is a unique growth factor which, unlike other members of the same BMP family, exhibits in addition to its strong pro-anabolic activity very prominent anti-catabolic properties. Animal studies have demonstrated that OP-1 has the ability to repair cartilage in vivo in various models of articular cartilage degradation, including focal osteochondral and chondral defects and osteoarthritis, as well as models of degeneration in intervertebral disc cartilage. Together our findings indicate a significant promise for OP-1 as therapeutic in cartilage repair.
Department of Biochemistry, Orthopedics and Section of Rheumatology (Department of Internal Medicine), Rush University Medical Center, Chicago, IL, 60612, USA.
Susan
S
Chubinskaya
Mark
M
Hurtig
David C
DC
Rueger
D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D002356:Cartilage / Q000502:physiology*; D004195:Disease Models, Animal; D004285:Dogs; D006706:Homeostasis / Q000502:physiology; D010003:Osteoarthritis / Q000503:physiopathology; D011817:Rabbits; D051381:Rats; D012038:Regeneration / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology*
C525821:Bmp7 protein, rat; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta