A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans.
Emotionally arousing events are recalled better than neutral events. This phenomenon, which helps us to remember important and potentially vital information, depends on the activation of noradrenergic transmission in the brain. Here we show that a deletion variant of ADRA2B, the gene encoding the alpha2b-adrenergic receptor, is related to enhanced emotional memory in healthy Swiss subjects and in survivors of the Rwandan civil war who experienced highly aversive emotional situations.
Division of Psychiatry Research, University of Zürich, Lenggstr. 31, 8032 Zürich, Switzerland. quervain@bli.unizh.ch
Dominique J-F
DJ
de Quervain
Iris-Tatjana
IT
Kolassa
Verena
V
Ertl
P Lamaro
PL
Onyut
Frank
F
Neuner
Thomas
T
Elbert
Andreas
A
Papassotiropoulos
D000704:Analysis of Variance; D044383:Black People / Q000235:genetics*; D004644:Emotions / Q000502:physiology*; D017353:Gene Deletion; D018698:Glutamic Acid / Q000235:genetics; D006801:Humans; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D044465:White People / Q000235:genetics*
C547771:ADRA2B protein, human; D018341:Receptors, Adrenergic, alpha-2; D018698:Glutamic Acid