Beta-catenin and CD44 expression in keratoacanthoma and squamous cell carcinoma of the skin.
CD44 and beta-catenin are adhesion molecules expressed on a wide variety of cells. Failure of this expression is believed to lead to disruption of cell-cell adhesion and to neoplasia. The aim of this study was to investigate the staining intensity of CD44 and beta-catenin in keratoacanthomas and squamous cell carcinomas of the skin. The proliferation index, PCNA staining, was also evaluated in these cases. The abnormal expression of beta-catenin significantly predominated in squamous cell carcinomas (n = 20, 76.9%) compared with keratoacanthomas (P = 0.002, chi2 = 7.8). Most keratoacanthomas (n = 11, 61.1%) more frequently showed strong staining intensity with CD44 compared with squamous cell carcinoma (P= 0.001, chi2 = 13.7). The proliferation index was higher in squamous cell carcinoma (P = 0.000, chi2 = 12.8). These findings suggest that CD44 and beta-catenin expression may have an important role in the development of malignancy and in the determination of biological features of keratoacanthoma and squamous cell carcinoma of the skin.
Adnan Menderes University School of Medicine, Department of Pathology, Aydin, Turkey. cantent@yahoo.com
Canten
C
Tataroglu
Tuba
T
Karabacak
Duygu Düşmez
DD
Apa
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D002455:Cell Division; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D007124:Immunoenzyme Techniques; D007636:Keratoacanthoma / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D012867:Skin; D012871:Skin Diseases / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D051176:beta Catenin / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics
C497483:CD44 protein, human; C495270:CTNNB1 protein, human; D018960:Hyaluronan Receptors; D009363:Neoplasm Proteins; D018809:Proliferating Cell Nuclear Antigen; D051176:beta Catenin