A small RNA makes a Bic difference.
The first highly specific knockouts of a microRNA, miR155, in mice result in multiple defects in adaptive immunity, and also show the feasibility of investigating at least some microRNAs by gene knockout.
Moffett
Howell F
HF
Cancer Immunology and AIDS, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Novina
Carl D
CD
D000818:Animals; D005786:Gene Expression Regulation; D007109:Immunity / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D035683:MicroRNAs / Q000235:genetics*
C524942:MIRN155 microRNA, human; D035683:MicroRNAs