Colorectal carcinogenesis: road maps to cancer.
This review explores the chief genetic and epigenetic events that promote pathological progression in colorectal carcinogenesis. This article discusses the molecular and pathological basis for classifying colorectal neoplasia into suppressor, mutator and methylator pathways. These differing mechanisms of genomic instability are associated with specific cancer characteristics, and may provide the opportunity for more effective prevention and surveillance strategies in the future. This is the first review in a series of five topics outlining important and developing aspects of colorectal cancer.
Conjoint Gastroenterology Laboratory, The Queensland Institute of Medical Research, the Bancroft Centre, rm H07, PO Royal Brisbane Hospital, Herston, QLD 4029, Australia. daniel.worthley@qimr.edu.au
Daniel-L
DL
Worthley
Vicki-L
VL
Whitehall
Kevin-J
KJ
Spring
Barbara-A
BA
Leggett
D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D019175:DNA Methylation; D016147:Genes, Tumor Suppressor; D042822:Genomic Instability; D006801:Humans