Impact of the metabolic syndrome on total arterial compliance in essential hypertension patients.
The aim of the study was to cross-sectionally analyze, in a group of essential hypertension patients without diabetes mellitus, the influence of the metabolic syndrome (MS) on the stroke volume index to pulse pressure (SVi/PP) ratio, a measure of total arterial compliance. A total of 528 essential hypertension patients, aged 18 to 72 years, free from cardiovascular and renal disease (41% of whom had MS) were enrolled. All participants underwent routine blood chemistry, echocardiographic examination, and 3 blood pressure measurements at the end of echocardiographic examination. When compared with participants who did not have MS, hypertensive patients with MS exhibited lower SVi/PP ratio (0.65+/-0.22 vs 0.73+/-0.21 mm Hg; P=.0003). The independent association of MS with SVi/PP ratio (beta=0.10; P=.02) was confirmed in a multivariate regression model including age, sex, and other potential confounders as covariates. The authors' finding may help to explain the enhanced cardiovascular risk associated with MS.
Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Universitá di Palermo, Italy. giusemme@unipa.it
Giuseppe
G
Mulé
Emilio
E
Nardi
Santina
S
Cottone
Paola
P
Cusimano
Alessandro
A
Palermo
Francesca
F
Incalcaterra
Maria Ester
ME
Giandalia
Giovanni
G
Cerasola
D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D013318:Stroke Volume