Resistance of the female, as opposed to the male, intestine to I/R-mediated injury is associated with increased resistance to gut-induced distant organ injury.
We tested the hypothesis that the female intestine is more resistant to gut I/R injury than the male intestine by comparing the effects of the isolated pure gut I/R superior mesenteric artery occlusion (SMAO) model on gut morphology and whether SMAO-induced distant organ injury (lung, bone marrow [BM], neutrophils, and red blood cells [RBCs]) would differ between male and proestrus female rats. At 6 or 24 h after SMAO or sham SMAO, gut injury, lung permeability, pulmonary neutrophil sequestration, RBC deformability, and BM RBC and white blood cell progenitor growth were measured, as was the ability of the plasma from these rats to activate naive rat neutrophils. At both 6 and 24 h after SMAO, the female rats had significantly less intestinal injury and reduced gut-induced lung injury, BM suppression, RBC dysfunction, and neutrophil activation than male rats subjected to SMAO. These results indicate that the resistance of proestrus female rats to gut injury and gut-induced distant organ injury is greater than that observed in male rats.
Deitch
Edwin A
EA
Department of Surgery, New Jersey Medical School, UMDNJ, Newark, NJ 07103, USA. edeitch@umdnj.edu
Feketeova
Eleonora
E
Lu
Qi
Q
Zaets
Sergy
S
Berezina
Tamara L
TL
Machiedo
George W
GW
Hauser
Carl J
CJ
Livingston
David H
DH
Xu
Da-Zhong
DZ
D000818:Animals; D004195:Disease Models, Animal; D004907:Erythrocyte Deformability; D005260:Female; D007422:Intestines / Q000098:blood supply* / Q000293:injuries*; D008026:Ligation; D008297:Male; D017538:Mesenteric Artery, Superior / Q000601:surgery; D009102:Multiple Organ Failure / Q000209:etiology*; D009504:Neutrophils / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000097:blood / Q000209:etiology*; D016897:Respiratory Burst; D012727:Sex Characteristics