Metabotropic glutamate receptors: phosphorylation and receptor signaling.
Metabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of mGluRs affects receptor signaling, trafficking, and desensitization. Here we review the emerging literature on mGluR phosphorylation, signaling, and synaptic function.
Kim
Chul Hoon
CH
Department of Pharmacology, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. kimhoon@yuhs.ac
Lee
Jinu
J
Lee
Jae-Youn
JY
Roche
Katherine W
KW
D000818:Animals; D008954:Models, Biological; D010766:Phosphorylation; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D018094:Receptors, Metabotropic Glutamate