Incomplete hierarchical data.
The researcher collecting hierarchical data is frequently confronted with incompleteness. Since the processes governing missingness are often outside the investigator's control, no matter how well the experiment has been designed, careful attention is needed when analyzing such data.We sketch a standard framework and taxonomy largely based on Rubin's work. After briefly touching upon (overly) simple methods,we turn to a number of viable candidates for a standard analysis, including direct likelihood, multiple imputation and versions of generalized estimating equations. Many of these require so-called ignorability. With the latter condition not necessarily satisfied, we also review flexible models for the outcome and missingnessprocesses at the same time. Finally, we illustrate how such methods can be very sensitive to modeling assumptions and then conclude with a number of routes for sensitivity analysis. Attention will be given to the feasibility of the proposed modes of analysis within a regulatory environment.
Beunckens
Caroline
C
Center for Statistics, Hasselt University, Diepenbeek, Belgium. caroline.beunckens@uhasselt.be
Molenberghs
Geert
G
Thijs
Herbert
H
Verbeke
Geert
G
D006801:Humans; D008137:Longitudinal Studies; D008268:Macular Degeneration / Q000628:therapy; D015233:Models, Statistical; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic