Ocular involvement as the initial manifestation of T-cell chronic lymphocytic leukemia.
OBJECTIVE
To present a case of T-cell chronic lymphocytic leukemia (T-CLL) manifesting as an intraocular lymphoma.


METHODS
Interventional case report.


METHODS
We performed a vitreous biopsy in a 67-year-old woman who presented with blurred vision and vitreous cellular infiltration. Morphologic, immunohistochemical, flow cytometry, and molecular analysis by polymerase chain reaction of vitreous fluid, peripheral blood, bone marrow aspirate, and biopsy were performed.


RESULTS
Cytofluorographic and molecular analysis of vitreous cells demonstrated a monoclonal T-cell population consistent with a T-cell intraocular lymphoma. Systemic evaluation established diagnosis of T-cell CLL.


CONCLUSIONS
T-CLL is a rare disease with an aggressive clinical course. We present a case of T-cell intraocular lymphoma as the initial manifestation of an otherwise asymptomatic T-CLL.
Calfa
Carmen J
CJ
Department of Medicine, Hematology-Oncology, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
Lossos
Izidore S
IS
Ruiz
Phillip
P
Davis
Janet L
JL
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics; D001706:Biopsy; D001854:Bone Marrow Cells / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D005434:Flow Cytometry; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007150:Immunohistochemistry; D015461:Leukemia, Prolymphocytic, T-Cell / Q000175:diagnosis* / Q000188:drug therapy; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000628:therapy; D015649:Pentostatin / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D041623:Tomography, Optical Coherence; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism / Q000473:pathology*
D000903:Antibiotics, Antineoplastic; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D015649:Pentostatin