55Cobalt complexes with pendant carbohydrates as potential PET imaging agents.
Bis-ligand cobalt(II) complexes of four 3-hydroxy-4-pyridinone ligands with pendant carbohydrates were synthesized and examined for their potential as radiopharmaceuticals. Non-radioactive complexes were prepared on the macroscopic scale and characterized by elemental analysis, mass spectrometry, IR and UV/visible spectroscopy. Facile radiolabeling produced the 55Co complexes in high radiochemical yields (>95%). Identification of the radiolabeled compounds was accomplished by HPLC comparison with the corresponding non-radioactive complexes.
TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, Canada V6T 2A3.
Cara L
CL
Ferreira
Suzanne
S
Lapi
Jennifer
J
Steele
David E
DE
Green
Thomas J
TJ
Ruth
Michael J
MJ
Adam
Chris
C
Orvig
D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003037:Cobalt Radioisotopes / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared
D002241:Carbohydrates; D003037:Cobalt Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals