[Prenatal tolerability evaluation of diclofenac].
Diclofenac is a nonsteroidal anti-inflammatory drug that nonselectively inhibits constitutive and inducible isoenzymes of cyclooxygenase. It's a potent anti-inflammatory, analgesic and antipyretic agent that recently belong to the over-the-counter drugs. Several animal studies on reproductive effect of diclofenac have been conducted. The overall results do not implicate the drug teratogenicity. However, intrauterine growth retardation, constriction of ductus arteriosus, fetal anuria, oligohydramnions and other prostanoid-related side-effects were already reported. On the other hand, data from human reports do not support opinion about the connection between diclofenac exposure and the potential risk to the fetus.
Akademia Medyczna w Lublinie, Pracownia Teratologii Doświadczalnej Katedry i Zakładu Anatomii Prawidłowej Człowieka.
Piotr
P
Przybylski
Joanna
J
Kiś
Franciszek
F
Burdan
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000633:toxicity; D001002:Anuria / Q000139:chemically induced / Q000196:embryology / Q000453:epidemiology; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects* / Q000633:toxicity; D004008:Diclofenac / Q000009:adverse effects* / Q000633:toxicity; D004373:Ductus Arteriosus / Q000187:drug effects / Q000196:embryology; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods; D011297:Prenatal Exposure Delayed Effects; D011817:Rabbits; D051381:Rats; D013723:Teratogens / Q000633:toxicity*; D016216:Ultrasonography, Prenatal
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D013723:Teratogens; D004008:Diclofenac