The minimum information required for reporting a molecular interaction experiment (MIMIx).
A wealth of molecular interaction data is available in the literature, ranging from large-scale datasets to a single interaction confirmed by several different techniques. These data are all too often reported either as free text or in tables of variable format, and are often missing key pieces of information essential for a full understanding of the experiment. Here we propose MIMIx, the minimum information required for reporting a molecular interaction experiment. Adherence to these reporting guidelines will result in publications of increased clarity and usefulness to the scientific community and will support the rapid, systematic capture of molecular interaction data in public databases, thereby improving access to valuable interaction data.
Orchard
Sandra
S
European Molecular Biology Laboratory (EMBL) - European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK. orchard@ebi.ac.uk
Salwinski
Lukasz
L
Kerrien
Samuel
S
Montecchi-Palazzi
Luisa
L
Oesterheld
Matthias
M
Stümpflen
Volker
V
Ceol
Arnaud
A
Chatr-aryamontri
Andrew
A
Armstrong
John
J
Woollard
Peter
P
Salama
John J
JJ
Moore
Susan
S
Wojcik
Jérôme
J
Bader
Gary D
GD
Vidal
Marc
M
Cusick
Michael E
ME
Gerstein
Mark
M
Gavin
Anne-Claude
AC
Superti-Furga
Giulio
G
Greenblatt
Jack
J
Bader
Joel
J
Uetz
Peter
P
Tyers
Mike
M
Legrain
Pierre
P
Fields
Stan
S
Mulder
Nicola
N
Gilson
Michael
M
Niepmann
Michael
M
Burgoon
Lyle
L
De Las Rivas
Javier
J
Prieto
Carlos
C
Perreau
Victoria M
VM
Hogue
Chris
C
Mewes
Hans-Werner
HW
Apweiler
Rolf
R
Xenarios
Ioannis
I
Eisenberg
David
D
Cesareni
Gianni
G
Hermjakob
Henning
H
D030562:Databases, Protein / Q000592:standards*; D017408:Guidelines as Topic; D006801:Humans; D016247:Information Storage and Retrieval / Q000592:standards*; D038622:Internationality; D025941:Protein Interaction Mapping / Q000592:standards*; D040901:Proteomics / Q000592:standards*; D012106:Research / Q000592:standards*