Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors.
Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.
Faggioli
Francesca
F
Istituto di Tecnologie Biomediche, CNR, Segrate, Milan, Italy.
Soldati
Sabina
S
Scanziani
Eugenio
E
Catò
Enrica Mira
EM
Adorni
Fulvio
F
Vezzoni
Paolo
P
Noonan
Douglas M
DM
Sacco
Maria Grazia
MG
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000628:therapy*; D016207:Cytokines / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005260:Female; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics*; D015674:Mammary Neoplasms, Animal / Q000235:genetics* / Q000628:therapy*; D008324:Mammary Tumor Virus, Mouse / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D008822:Mice, Transgenic; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation
D016207:Cytokines; D018664:Interleukin-12; D004247:DNA