Studies on gynecological hydrophilic lactic acid preparations. Part 8: use of chitosan as lactic acid carrier in intravaginal tablets.
Hydrophilic intravaginal tablets based on methylcellulose and containing lactic acid component with chitosan undergo swelling under standard conditions. A high flow-limit of the gel that originates from the tablets as well as its dynamic viscosity should allow for the durable dosage form in the vagina. By choosing the 1:1 ratio of lactic acid to chitosan, it is possible to obtain tablets disintegrating into a gelform at physiological pH range of 3.8-4.4. An increase in the amount of lactic acid in the complex in relation to the polymer up to 2:1 and 3:1 ratios results in gels with a lower pH. These gels possess an acid reserve that might act to neutralize the excess of alkali present in severe vaginal infections.
Department of Pharmaceutical Technology, Faculty of Pharmacy, The Silesian Piasts Memorial Medical University of Wrocław, 38 Szewska Str., 50-139 Wrocław, Poland.
Katarzyna
K
Małolepsza-Jarmołowska
D000269:Adhesives; D000282:Administration, Intravaginal; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000008:administration & dosage / Q000737:chemistry*; D008747:Methylcellulose / Q000737:chemistry; D013607:Tablets; D014621:Vagina / Q000737:chemistry; D014783:Viscosity
D000269:Adhesives; D004337:Drug Carriers; D005782:Gels; D013607:Tablets; D019344:Lactic Acid; D008747:Methylcellulose; D048271:Chitosan