An adaptable internal dose model for risk assessment of dietary and soil dioxin exposures in young children.
An adaptable model is presented for assessing the blood lipid concentrations of polychlorodibenzodioxins and polychlorodibenzofurans (PCDD/Fs) from dietary (breast milk, formula, milk, and other foods) and soil pathway exposures (soil ingestion and dermal contact) utilizing age-specific exposure and intake estimates for young children. The approach includes a simple one-compartment (adipose volume) toxicokinetic model that incorporates empirical data on age-dependent half-lives and bioavailability of PCDD/F congeners, child body size and intake rates, and recent data on breast milk and food dioxin levels. Users can enter site-specific soil concentration data on 2,3,7,8-chlorinated PCDD/F congeners for specific assessment of body burden changes from soil pathways in combination with background dietary exposures from birth through age 7 years. The model produces a profile of the estimated PCDD/F concentration in blood lipid (in World Health Organization 1998 dioxin toxic equivalents) versus time for a child from birth through age 7 years. The peak and time-weighted average (TWA) internal dose (defined as blood lipid dioxin toxic equivalents) for a variety of specific child exposure assumptions can then be compared to safe internal dose benchmarks for risk assessment purposes, similar to an approach taken by United States Environmental Protection Agency for assessing child lead exposures. We conclude that this adaptable toxicokinetic model can provide a more comprehensive assessment of potential health risks of PCDD/Fs to children because it integrates recent empirical findings on PCDD/F kinetics in humans and allows users to assess contributions from varied dietary and site-specific environmental exposure assumptions.
Kerger
Brent D
BD
Health Science Resource Integration, Tallahassee, Florida 32309, USA. brentkerger@att.net
Leung
Hon-Wing
HW
Scott
Paul K
PK
Paustenbach
Dennis J
DJ
D000273:Adipose Tissue / Q000378:metabolism; D000367:Age Factors; D000465:Algorithms; D001572:Benzofurans / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D001682:Biological Availability; D001822:Body Burden; D049628:Body Size; D002648:Child; D002675:Child, Preschool; D000072338:Dibenzofurans, Polychlorinated; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D005506:Food Contamination; D006207:Half-Life; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood; D008895:Milk, Human / Q000737:chemistry; D008954:Models, Biological; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity; D015203:Reproducibility of Results; D018570:Risk Assessment; D012989:Soil Pollutants / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D008055:Lipids; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants