RIG-I family RNA helicases: cytoplasmic sensor for antiviral innate immunity.
Viral infection is detected by cellular sensors as foreign nucleic acid and initiates innate antiviral responses, including the activation of type I interferon (IFN) and proinflammatory cytokines. Recent advances in cytoplasmic virus sensors highlight their essential role in the induction of innate immunity. Moreover, it is intriguing to understand how they can discriminate innate RNA from viral foreign RNA. In this mini-review, we focus on these cytoplasmic virus sensors, termed retinoic acid inducible gene-I (RIG-I)-like receptors (RLRs), and discuss their function in the innate immune system.
Yoneyama
Mitsutoshi
M
Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.
Fujita
Takashi
T
D000818:Animals; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000276:immunology*; D007113:Immunity, Innate; D018168:Receptors, Retinoic Acid / Q000276:immunology*; D015398:Signal Transduction; D014764:Viral Proteins / Q000276:immunology
D018168:Receptors, Retinoic Acid; D014764:Viral Proteins; C503356:Ddx58 protein, mouse; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases