[Physiological effects of cold and cool Chinese herbal medicine of channel tropism of stomach on rats with stomach-heat syndrome].
OBJECTIVE
Stomach physiological effects of channel tropism of stomach, cold & cool Chinese herbal medicine on rats with stomach-heat syndrome were studied.


METHODS
Using water decoction of warm &heat medicine, Rhizoma Zingiberis to feed rats for 15 days continuously, causing the stomach-heat sydrome model, then decoction of Rhizoma Coptidis, Herba Taraxaci, Fractus Aurantii Immaturus was used to feed rats for 10 days, respectively. Biochemical indexes of blood reflecting the physiological function of stomach, including thromboxaneB2 (TXB2), 6-keto-PGF(1alpha), Gastrin (Gas), Motilin (MTL), and Somatostation (SS) were measured by radioimmunoassay.


RESULTS
Symptom of stomach-heat syndrome prevailed in body of rats after filled with decoction of Rhizoma Zingiberis, values of TXB2/6-keto-PGF(1alpha), MTL, and Gas in blood raised up evidently, compared with the control (P < 0.05), but values of 6-keto-PGF(1alpha). decreased conspicuously (P < 0.05). After treated with decoction of Rhizoma Coptidis, Herba Taraxaci or Fractus Aurantii Immaturus for 10 days, respectively. Symptoms of stomach heat syndrome were eliminated or alleviated, values of 6-keto-PGF(1alpha), and SS in blood elevated at different degrees, and those of TXB2, TXB2/6-keto-PGF(1alpha), MTL, and Gas felled down at different degrees. Difference of efficacy existed at different groups, group of Rhizoma Coptidis was the strongest, group of Herba Taraxaci was the second, group of Fractus Aurantii Immaturus was the third. Efficacy of medicine in groups with high dosage was stronger than those with low dosage.


CONCLUSIONS
Channel tropism of stomach, cold and cool Chinese herbal medicine could improve the physiological functions of stomach effectively, and the efficacy concerns with the degree of their cold and cool characteristics.
Guangdong Provincial Key Lab of Biotechnology for Plant Development, South China Normal University, Guangzhou 510631, China.
Xiao-mei
XM
Li
Xu-e
XE
Li
Gui-bo
GB
Sun
Jin-zhu
JZ
Liu
Bao-jiang
BJ
Guo
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D002957:Citrus / Q000737:chemistry; D039323:Coptis / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005755:Gastrins / Q000097:blood; D020939:Zingiber officinale; D008297:Male; D008516:Medicine, Chinese Traditional; D009037:Motilin / Q000097:blood; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000097:blood; D013272:Stomach Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D013577:Syndrome; D031205:Taraxacum / Q000737:chemistry; D013929:Thromboxane B2 / Q000097:blood
D004365:Drugs, Chinese Herbal; D005755:Gastrins; D013004:Somatostatin; D009037:Motilin; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha