Cellular senescence: when bad things happen to good cells.
Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing.
Campisi
Judith
J
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA. jcampisi@lbl.gov
d'Adda di Fagagna
Fabrizio
F
D000375:Aging; D000818:Animals; D002453:Cell Cycle; D016922:Cellular Senescence / Q000502:physiology*; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000209:etiology*