TIM-3 as a therapeutic target in human inflammatory diseases.
T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) was the first, and is presently the only, surface molecule that can specifically identify T(H)1 cells in both mice and humans. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear.
Anderson
David E
DE
Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, MA 02115, Boston, USA. danderson@rics.bwh.harvard.edu
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D016503:Drug Delivery Systems / Q000379:methods*; D000072597:Hepatitis A Virus Cellular Receptor 2; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism* / Q000502:physiology; D008565:Membrane Proteins; D011991:Receptors, Virus / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology
C448908:HAVCR2 protein, human; D000072597:Hepatitis A Virus Cellular Receptor 2; D018836:Inflammation Mediators; D008565:Membrane Proteins; D011991:Receptors, Virus