The non-genomic crosstalk between PPAR-gamma ligands and ERK1/2 in cancer cell lines.
Peroxisome proliferator activated receptors (PPARs) are members of the nuclear receptor superfamily acting as transcription factors. PPAR-gamma, one of the three PPAR subtypes, is expressed in many malignant and non-malignant cells and tissues. PPAR-gamma ligands influence cancer biology via both genomic as well as non-genomic events. The non-genomic action of PPAR-gamma ligands, including the activation of MAPK signaling pathways, is under intense investigation. In the presence of PPAR-gamma ligands, a rapid phosphorylation of ERK1/2 is observed in many cancer cell lines. Activated ERK1/2 elicits rapid, non-genomic cellular effects and can directly repress PPAR-gamma transcriptional activity by phosphorylation. This paper reviews the interrelation of PPAR-gamma ligands and activated ERK1/2, in relation to their antineoplastic actions in cancer cell lines, which may offer the potential for improved anticancer therapies.
National & Kapodistrian University of Athens, Department of Experimental Physiology, Medical School, Goudi-Athens, Greece.
Efstathia
E
Papageorgiou
Nea
N
Pitulis
Pavlos
P
Msaouel
Peter
P
Lembessis
Michael
M
Koutsilieris
D000818:Animals; D045744:Cell Line, Tumor; D006131:Growth Inhibitors / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008024:Ligands; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000517:prevention & control; D047495:PPAR gamma / Q000378:metabolism*; D020239:Receptor Cross-Talk / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D006131:Growth Inhibitors; D008024:Ligands; D047495:PPAR gamma; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3