Predicting hypothetical willingness to participate (WTP) in a future phase III HIV vaccine trial among high-risk adolescents.
The present study sought to determine whether the Theory of Planned Behaviour predicted stated hypothetical willingness to participate (WTP) in future Phase III HIV vaccine trials among South African adolescents. Hierarchical logistic regression analyses showed that The Theory of Planned Behaviour (TPB) significantly predicted WTP. Of all the predictors, Subjective norms significantly predicted WTP (OR = 1.19, 95% C.I. = 1.06-1.34). A stepwise logistic regression analysis revealed that Subjective Norms (OR = 1.19, 95% C.I. = 1.07-1.34) and Attitude towards participation in an HIV vaccine trial (OR = 1.32, 95% C.I. = 1.00-1.74) were significant predictors of WTP. The addition of Knowledge of HIV vaccines and HIV vaccine trials, Perceived self-risk of HIV infection, Health-promoting behaviours and Attitudes towards HIV/AIDS yielded non-significant results. These findings provide support for the Theory of Reasoned Action (TRA) and suggest that psychosocial factors may play an important role in WTP in Phase III HIV vaccine trials among adolescents.
Department of Psychology, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.
Georgina
G
Giocos
Ashraf
A
Kagee
Leslie
L
Swartz
D016915:AIDS Vaccines / Q000008:administration & dosage*; D000293:Adolescent; D017326:Clinical Trials, Phase III as Topic / Q000523:psychology*; D005260:Female; D005544:Forecasting; D015658:HIV Infections / Q000517:prevention & control* / Q000523:psychology; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D010358:Patient Participation / Q000523:psychology* / Q000706:statistics & numerical data; D011584:Psychology; D013019:South Africa; D011795:Surveys and Questionnaires; D014838:Volunteers / Q000523:psychology / Q000706:statistics & numerical data; D055815:Young Adult
D016915:AIDS Vaccines