[Interferon in the treatment of viral hepatitis. The interferon was discovered 50 years ago].
The interferons are heterogenic glycoproteins which are produced on the effect of virus infection, as immune answer, by the living cells. They were discovered half a century ago. They have antineoplastic, antiviral and immunomodulator effect. The names of interferons used in the therapy are nominated with Greek letters. This nomination shows their origins: the interferon-alpha originates from leucocytes, the interferon-beta does from fibroblasts and the interferon-gamma is produced as immune interferon by lymphocytes. In human medicine both natural and recombinant interferons are applied. The connection of polyethyleneglycol to interferons ensures their sustained effect. Nowadays they are applied in the therapy of chronic hepatitis B or C as well as in oncology to inhibit the neoplasm progression.
Fehér
János
J
Semmelweis Egyetem, Altalános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088. feher@bel2.sote.hu
Lengyel
Gabriella
G
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000266:history / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005347:Fibroblasts; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000266:history; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D016899:Interferon-beta / Q000627:therapeutic use; D007371:Interferon-gamma / Q000627:therapeutic use; D007372:Interferons / Q000096:biosynthesis / Q000266:history / Q000627:therapeutic use*; D007962:Leukocytes; D008214:Lymphocytes; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011994:Recombinant Proteins; D012254:Ribavirin / Q000627:therapeutic use; D009626:Terminology as Topic
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; D016899:Interferon-beta; D007371:Interferon-gamma; D007372:Interferons; C417083:peginterferon alfa-2b; C100416:peginterferon alfa-2a