Development of mast cells: analysis with mutant mice.
Mast cells are the progeny of hematopoietic stem cells. Mutant mice lacking mast cells or possessing abnormal mast cells, such as W/Wv, Sl/Sld, and mi/mi, are useful for investigating the developmental process. Recently, mast cell progenitors were identified with sorting techniques. Recent progress in research into mast cell development is reviewed.
Morii
Eiichi
E
Department of Pathology, Osaka University School of Medicine, Osaka, Japan. morii@patho.med.osaka-u.ac.jp
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics* / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains / Q000502:physiology*; D010641:Phenotype; D019089:Stem Cell Factor / Q000378:metabolism
D015703:Antigens, CD; D019089:Stem Cell Factor