PIK3CA gene amplification in Japanese non-small cell lung cancer.
We have investigated 92 non-small cell lung cancer tissues and found 11 PIK3CA amplification. PIK3CA amplification incidence was significantly higher in male, smoker and squamous cell carcinoma patients. Among 11 patients with PIK3CA amplification, two patients harbored a PIK3CA mutation. There was significant difference in survival between the patients with PIK3CA normal copy number and the patients with PIK3CA amplification.
Kawano
Osamu
O
Sasaki
Hidefumi
H
Okuda
Katsuhiro
K
Yukiue
Haruhiro
H
Yokoyama
Tomoki
T
Yano
Motoki
M
Fujii
Yoshitaka
Y
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality; D058534:Class I Phosphatidylinositol 3-Kinases; D005260:Female; D005784:Gene Amplification; D005819:Genetic Markers; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality; D008297:Male; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics*; D012737:Sex Factors; D012907:Smoking; D016019:Survival Analysis
D005819:Genetic Markers; D019869:Phosphatidylinositol 3-Kinases; D058534:Class I Phosphatidylinositol 3-Kinases; C484760:PIK3CA protein, human