title: Comparative genomics of leucine-rich repeats containing G protein-coupled receptors and their ligands.
abstract: Leucine-rich repeats containing G protein-coupled receptors (LGRs) constitute a unique cluster of transmembrane proteins sharing a large leucine-rich extracellular domain for hormone binding. In mammals, LGRs steer important developmental, metabolic and reproductive processes as receptors for glycoprotein hormones and insulin/relaxin-related proteins. In insects, a receptor structurally related to human LGRs mediates the activity of the neurohormone bursicon thereby regulating wing expansion behaviour and remodelling of the newly synthesized exoskeleton. In the past decade, novel insights into the molecular evolution of LGR encoding genes accumulated rapidly due to comparative genome analyses indicating that the endocrine LGR signalling system likely emerged before the radiation of metazoan phyla and expanded throughout evolution. Here, we present a short survey on the evolution of LGRs and the hormones they interact with.
authors: Department of Animal Physiology and Neurobiology, Molecular Developmental Physiology and Signal Transduction Research Group, Zoological Institute K.U.Leuven, Naamsestraat 59, B-3000 Leuven, Belgium.
authors: Tom
authors: T
authors: Van Loy
authors: Hans Peter
authors: HP
authors: Vandersmissen
authors: Matthias B
authors: MB
authors: Van Hiel
authors: Jeroen
authors: J
authors: Poels
authors: Heleen
authors: H
authors: Verlinden
authors: Liesbeth
authors: L
authors: Badisco
authors: Gilbert
authors: G
authors: Vassart
authors: Jozef
authors: J
authors: Vanden Broeck
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D023281:Genomics / Q000379:methods*; D048788:Growth and Development / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000235:genetics; D007447:Invertebrate Hormones / Q000235:genetics / Q000378:metabolism; D000090263:Leucine-Rich Repeat Proteins; D008024:Ligands; D008954:Models, Biological; D008969:Molecular Sequence Data; D010802:Phylogeny; D011506:Proteins / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
chemical_list: D007328:Insulin; D007447:Invertebrate Hormones; D000090263:Leucine-Rich Repeat Proteins; C084797:Leydig insulin-like protein; D008024:Ligands; D011506:Proteins; D043562:Receptors, G-Protein-Coupled; C002295:bursicon