Insight into the reactive form of the anticancer agent iproplatin.
The reaction of iproplatin with reduced glutathione at different mole ratios yielded cis-di(isopropylamine)chloro-glutathionatoplatinum(II), not the expected cis-dichloro- species, indicating a mode of action of this anticancer agent that is different from that of cis-diamminedichloroplatinum(II).
Volckova
Erika
E
Michael Faraday Laboratory, Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL 60115, United States.
Weaver
Evelyne
E
Bose
Rathindra N
RN
D000970:Antineoplastic Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D005978:Glutathione / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009944:Organoplatinum Compounds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C023359:iproplatin; D005978:Glutathione