[Propofol does not induce retrograde amnesia at the hypnotic dose].
BACKGROUND
We evaluated retrograde amnesic effects of propofol at the hypnotic dose on 28 healthy medical personnel volunteers (17 men, 11 women).


METHODS
Explicit memory function was measured after the emergence from bolus infusion of propofol 2 mg x kg(-1); how one could answer the correct number and symbol of 5 playing cards which he had picked up randomly and intentionally memorized before induction? As control, one also took the same test during working hour without any drugs.


RESULTS
After infusion of propofol, the rate of correct answers was 96.4 +/- 9.1% and in control, it was 92.1 +/- 18.3% (P = 0.297142). There was no significant difference among two situations.


CONCLUSIONS
These results suggest that propofol dose not induce retrograde amnesia at hypnotic dose.
Hashimoto
Kazuyoshi
K
Department of Anesthesiology, Hanyu General Hospital, Hanyu 348-8505.
Okada
Takayuki
T
Seo
Norimasa
N
D000328:Adult; D000648:Amnesia, Retrograde / Q000139:chemically induced; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects*
D006993:Hypnotics and Sedatives; D015742:Propofol