title: Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens.
abstract: Recombinant phenotyping of cytomegalovirus (CMV) pol region III mutations from clinical specimens showed that T813S and G841A each conferred foscarnet resistance and approximately threefold increased ganciclovir resistance; adding the UL97 mutation C592G increased ganciclovir resistance to approximately sixfold. Bacterial artificial chromosome CMV clones containing pol mutation L845P were nonviable unless repaired with the wild-type sequence.
authors: Divisionof Infectious Disease, Oregon Health Science University, VA Medical Center, Portland, OR 97239, USA. chous@ohsu.edu
authors: Sunwen
authors: S
authors: Chou
authors: Gail I
authors: GI
authors: Marousek
authors: Laura C
authors: LC
authors: Van Wechel
authors: Shaobing
authors: S
authors: Li
authors: Adriana
authors: A
authors: Weinberg
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D003586:Cytomegalovirus Infections / Q000821:virology; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D024882:Drug Resistance, Viral / Q000235:genetics*; D017245:Foscarnet / Q000494:pharmacology; D015774:Ganciclovir / Q000494:pharmacology; D005838:Genotype; D006801:Humans; D009154:Mutation; D010641:Phenotype
chemical_list: D000998:Antiviral Agents; D017245:Foscarnet; D004259:DNA-Directed DNA Polymerase; D015774:Ganciclovir
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