Cyclin D1 expression and histopathologic features in vestibular schwannomas.
OBJECTIVE
To evaluate cyclin D1 expression in vestibular schwannoma and its relationship with histologic, clinical, and radiologic features.


METHODS
Twenty-one patients with histologically confirmed vestibular schwannoma.


METHODS
Immunohistochemistry analysis was performed with anticyclin D1. Histopathologic features studied included Antoni pattern and nuclear and stromal degenerative changes. Clinical charts, audiometric data, and magnetic resonance imaging characteristics were reviewed.


METHODS
Cyclin D1 expression and its association with histologic, clinical, and radiologic findings.


RESULTS
Cyclin D1 expression was found in 52% of cases. Cyclin D1 expression was more frequent in right-sided tumors (p = 0.02) and in tumors with nuclear degenerative changes (p < 0.0001). Patients with negative cyclin D1 expression had longer duration of deafness (p = 0.02) and higher 2,000-Hz hearing thresholds (p = 0.04) than cyclin D1+ patients.


CONCLUSIONS
Cyclin D1 expression, present in nearly half of the cases, may play a role in the development of these tumors. Further studies are needed to fully understand the contributions of histopathologic and immunohistochemical factors to vestibular schwannoma biological activity.
Lassaletta
Luis
L
Department of Otolaryngology, Laboratorio Oncogenetica Molecular, La Paz University Hospital, Madrid, Spain. luikilassa@yahoo.com
Patrón
Mercedes
M
Del Río
Laura
L
Alfonso
Carolina
C
Roda
Jose Maria
JM
Rey
Juan A
JA
Gavilan
Javier
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001299:Audiometry; D003390:Cranial Nerve Neoplasms / Q000235:genetics* / Q000473:pathology*; D003638:Deafness / Q000209:etiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D019940:Genes, bcl-1 / Q000235:genetics*; D034381:Hearing Loss / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000235:genetics* / Q000473:pathology*; D016612:Paraffin Embedding; D014726:Vestibular Nuclei / Q000473:pathology; D000160:Vestibulocochlear Nerve Diseases / Q000235:genetics* / Q000473:pathology*