title: A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy.
abstract: OBJECTIVE
  In order to facilitate the use of the PET-based Strauss test for 5-FU sensitivity, a rapid and facile synthesis of [2-11C]5-fluorouracil ([2-11C]5-FU), based on = [11C]phosgene ([11C]COCl2), is reported.
  
  
  METHODS
  The key intermediate (E)-beta- benzoylamino-Alpha-fluoroacrylamide (1) and [11C]phosgene was submitted to cyclocondensation to give [2-11C]5-fluorouracil.
  
  
  RESULTS
  [2-11C]5-Fluorouracil was synthesized in 17 min with high (25%) radiochemical yield.
  
  
  CONCLUSIONS
  The present study provides a rapid, simple, and efficient synthesis of [2-11C]5-FU, that would serve as a useful prognostic PET tracer for 5-FU chemotherapy.
authors: Central Institute of Radio Isotope Science, Hokkaido University, Kita-ku, Sapporo, Japan. seki@ric.hokudai.ac.jp
authors: Koh-ichi
authors: K
authors: Seki
authors: Ken-ichi
authors: K
authors: Nishijima
authors: Yuji
authors: Y
authors: Kuge
authors: Nagara
authors: N
authors: Tamaki
authors: Leonard I
authors: LI
authors: Wiebe
authors: Kazue
authors: K
authors: Ohkura
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000737:chemistry* / Q000627:therapeutic use; D002250:Carbon Radioisotopes; D005472:Fluorouracil / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D049268:Positron-Emission Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D000964:Antimetabolites, Antineoplastic; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D005472:Fluorouracil