title: Modulating effect of Phyllanthus fruit extract against lead genotoxicity in germ cells of mice.
abstract: The objective of the present study was to evaluate the protective effect of Phyllanthus emblica against clastogenicity induced by lead nitrate on the incidence of sperm head abnormalities in the germ cells of mice. At higher concentration of lead, a significant increase in the percentage of sperm head abnormalities was noted but when animals primed with Phyllanthus fruit extract (PFE), a reduction in the frequency of sperm head abnormalities was observed. It can be suggested from the above study that Phyllanthus emblica plays a key role in inhibition of heavy metal mutagenesis in mammals.
authors: Department of Zoology, College of Science, Osmania University, Hyderabad - 500 007, India. madhavi_sangam@yahoo.com
authors: D
authors: D
authors: Madhavi
authors: K Rudrama
authors: KR
authors: Devil
authors: K Kesava
authors: KK
authors: Rao
authors: P P
authors: PP
authors: Reddy
mesh_terms: D000818:Animals; D005638:Fruit / Q000737:chemistry; D007854:Lead / Q000633:toxicity*; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D009566:Nitrates / Q000633:toxicity*; D029803:Phyllanthus / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology; D020011:Protective Agents / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology
chemical_list: D009153:Mutagens; D009566:Nitrates; D010936:Plant Extracts; D020011:Protective Agents; D007854:Lead; C017461:lead nitrate