Balanced calcitriol treatment to make children grow.
Short stature is an important clinical problem in children with chronic kidney disease. Calcitriol is used as standard therapy to control secondary hyperparathyroidism, but its effect on linear growth remains controversial. Sanchez and He report multiple effects of calcitriol on chondrocyte proliferation and maturation that might help to clarify this controversy.
Neven
E
E
Department of Pathophysiology, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.
Persy
V
V
D'Haese
P C
PC
D000818:Animals; D002117:Calcitriol / Q000627:therapeutic use*; D049109:Cell Proliferation; D002648:Child; D019902:Chondrocytes / Q000166:cytology / Q000187:drug effects*; D006128:Growth / Q000187:drug effects*; D006130:Growth Disorders / Q000139:chemically induced; D006801:Humans; D006961:Hyperparathyroidism / Q000188:drug therapy; D007674:Kidney Diseases / Q000188:drug therapy
D002117:Calcitriol