title: Oxygen metabolism changes in patients with idiopathic normal pressure hydrocephalus before and after shunting operation.
abstract: OBJECTIVE
  The present study revealed the changes in cerebral oxygen metabolism before and after ventriculo-peritoneal shunt (VPS) using (15)O positron emission tomography ((15)O-PET).
  
  
  METHODS
  Eight patients with idiopathic normal pressure hydrocephalus (i-NPH) underwent VPS. A (15)O-PET study was undertaken before and approximately 3 months after VPS. In five patients, the symptoms improved based on the classification by Krauss et al. [Neurosurgery 1996;39:292] (good responders) after VPS. In three patients, the symptoms improved subjectively following VPS (poor responders). The changes in oxygen metabolism before and after VPS were analyzed.
  
  
  RESULTS
  The postoperative regional cerebral metabolic rate of oxygen (rCMRO(2)) of the good responders increased significantly. The postoperative regional oxygen extraction fraction (rOEF) is reduced in the poor responders.
  
  
  CONCLUSIONS
  The improvement of rCMRO(2) correlated with the response to VPS. Significant changes in rOEF might predict poor response to VPS.
authors: Department of Neurosurgery, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan. miyapoo850@yahoo.co.jp
authors: J
authors: J
authors: Miyamoto
authors: K
authors: K
authors: Tatsuzawa
authors: Y
authors: Y
authors: Inoue
authors: Y
authors: Y
authors: Imahori
authors: K
authors: K
authors: Mineura
mesh_terms: D000368:Aged; D001810:Blood Volume / Q000502:physiology; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology*; D049268:Positron-Emission Tomography; D016896:Treatment Outcome; D017287:Ventriculoperitoneal Shunt