title: Evaluation of short-term and subchronic toxicity of magnolia bark extract in rats.
abstract: Magnolia bark has been traditionally used in Chinese and Japanese medicines, and its extract is a constituent of currently marketed dietary supplements and cosmetic products. The safety of magnolia bark extract (MBE) was assessed in short-term and subchronic studies. In a 21-day pilot study, rats were administered MBE at levels of 0, 60, 120, 240 or 480 mg/kg body weight (bw)/day in the diet. There were no treatment-related effects in clinical observations, macroscopic or microscopic findings, hematological, clinical chemistry, urinalysis, or organ weight measurements, and there were no deaths or significant differences in body weight and weight gain. In the 90-day study, rats were administered 0, 60, 120 or 240 mg MBE/kg bw/day in the diet. No mortality, ophthalmic abnormalities or treatment-related findings in clinical observations, hematology, coagulation or organ weight measurements were observed. There were no treatment-related macroscopic or microscopic findings. Differences between treated and control groups in body weight, weight gain, food consumption and utilization, clinical chemistry and urinalysis parameters were not considered toxicologically significant as they were not dose-related and/or because values remained within historical control ranges. These results support the safety of MBE for oral consumption.
authors: Department of Toxicological Safety Assessment, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China.
authors: Zhaoping
authors: Z
authors: Liu
authors: Xiaopeng
authors: X
authors: Zhang
authors: Wenming
authors: W
authors: Cui
authors: Xin
authors: X
authors: Zhang
authors: Ning
authors: N
authors: Li
authors: Junshi
authors: J
authors: Chen
authors: Andrea W
authors: AW
authors: Wong
authors: Ashley
authors: A
authors: Roberts
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001663:Bilirubin / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D004906:Erythrocyte Count; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D031566:Magnolia / Q000737:chemistry*; D008297:Male; D009336:Necrosis; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D010865:Pilot Projects; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013961:Thyroid Gland / Q000187:drug effects / Q000473:pathology; D036401:Toxicity Tests, Chronic / Q000379:methods*; D016482:Urinalysis / Q000379:methods; D014599:Uterus / Q000187:drug effects / Q000473:pathology; D015430:Weight Gain / Q000187:drug effects
chemical_list: D010936:Plant Extracts; D001663:Bilirubin