title: Xanthogranulomatous endometritis: a challenging imitator of endometrial carcinoma.
abstract: Xanthogranulomatous inflammation is a distinguished histopathological entity affecting several organs, predominantly the kidney and gallbladder. So far, only a small number of cases of xanthogranulomatous inflammation occurring in female genital tract have been described, most frequently affecting the endometrium and histologically characterized by replacement of endometrium by xanthogranulomatous inflammation composed of abundant foamy histiocytes, siderophages, giant cells, fibrosis, calcification and accompanying polymorphonuclear leucocytes, plasma cells and lymphocytes of polyclonal origin. We present a case of a 69-year-old female complained of post menopausal bleeding and weight loss. Clinical preliminary diagnoses were endometrial carcinoma or hyperplasia and ultrasound was supposed to be endometrial malignancy, hyperplasia or pyometra by radiologist. Histopathological examination of uterus revealed xanthogranulomatous endometritis. Since xanthogranulomatous endometritis may mimic endometrial malignancy clinically and pathologically as a result of the replacement of the endometrium and occasionally invasion of the myometrium by friable yellowish tissue composed of histiocytes, knowledge of this unusual inflammatory disease is needed for both clinicians and pathologists.
authors: Department of Pathology, School of Medicine, Yeditepe University, Istanbul, Turkey.
authors: A Işin
authors: AI
authors: Doğan-Ekici
authors: Alp
authors: A
authors: Usubütün
authors: Türkan
authors: T
authors: Küçükali
authors: Ali
authors: A
authors: Ayhan
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D004716:Endometritis / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006099:Granuloma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D017698:Postmenopause; D014592:Uterine Hemorrhage / Q000209:etiology; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology*; D015431:Weight Loss
references: Pathology. 1978 Apr;10(2):161-4
references: 683700
references: Histopathology. 1980 Jan;4(1):105-10
references: 7353813
references: Acta Obstet Gynecol Scand. 1983;62(3):193-7
references: 6624390
references: APMIS. 2006 May;114(5):386-8
references: 16725016
references: Appl Pathol. 1989;7(4):273-6
references: 2803790
references: Arch Pathol Lab Med. 1990 Sep;114(9):929-32
references: 2390008
references: Arch Pathol Lab Med. 1985 Jan;109(1):73-5
references: 3838238