Structure-based drug design: docking and scoring.
This review gives an introduction into ligand - receptor docking and illustrates the basic underlying concepts. An overview of different approaches and algorithms is provided. Although the application of docking and scoring has led to some remarkable successes, there are still some major challenges ahead, which are outlined here as well. Approaches to address some of these challenges and the latest developments in the area are presented. Some aspects of the assessment of docking program performance are discussed. A number of successful applications of structure-based virtual screening are described.
Kroemer
Romano T
RT
Computational Sciences, Department of Chemistry, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano (MI), Italy. romano.kroemer@sanofi-aventis.com
D000465:Algorithms; D001185:Artificial Intelligence; D019295:Computational Biology; D003198:Computer Simulation; D017076:Computer-Aided Design; D015195:Drug Design; D021621:Imaging, Three-Dimensional; D008024:Ligands; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D012984:Software; D013329:Structure-Activity Relationship
D008024:Ligands