Proteoglycan biosynthesis during chondrogenic differentiation of mesenchymal stem cells.
Mesenchymal stem cells are multipotent progenitor cells that can differentiate into the chondrogenic lineage. To date, only limited knowledge about the formation and remodeling of the cartilaginous extracellular matrix is available. We recently analyzed the coordinated expression of proteins involved in the biosynthesis of proteoglycans and collagens, the two major components of cartilage matrix, to understand matrix formation and to provide potential tools to improve the quality of tissue-engineered cartilage.
Götting
Christian
C
Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum, Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany. cgoetting@hdz-nrw.de
Prante
Christian
C
Kuhn
Joachim
J
Kleesiek
Knut
K
D002356:Cartilage / Q000254:growth & development; D002454:Cell Differentiation / Q000502:physiology; D020219:Chondrogenesis / Q000502:physiology*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D010430:Pentosyltransferases / Q000502:physiology; D011509:Proteoglycans / Q000096:biosynthesis*; D023822:Tissue Engineering; D000097608:UDP Xylose-Protein Xylosyltransferase
D010430:Pentosyltransferases; D011509:Proteoglycans; D000097608:UDP Xylose-Protein Xylosyltransferase