Transfected cell microarrays: an efficient tool for high-throughput functional analysis.
Transfected cell microarrays are considered to be a breakthrough methodology for high-throughput and high-content functional genomics. Here, recent advances in the cell microarray field are reviewed, along with its potential to increase the speed of determining gene function. These advances, combined with an increasing number and diversity of gene perturbing systems, such as RNAi and ectopic gene expression, provide tools for expanding our understanding of biology at the systems level.
Starkuviene
Vytaute
V
European Molecular Biology Laboratory, Cell Biology & Cell Biophysics Unit, Heidelberg, Germany. vytaute.starkuviene@bioquant.uni-heidelberg.de
Pepperkok
Rainer
R
Erfle
Holger
H
D000818:Animals; D018076:DNA, Complementary; D051379:Mice; D041681:NIH 3T3 Cells; D034622:RNA Interference; D015203:Reproducibility of Results; D046888:Tissue Array Analysis / Q000379:methods*; D014162:Transfection
D018076:DNA, Complementary