title: Sustained fever resolved promptly after total thyroidectomy due to huge Hashimoto's fibrous thyroiditis.
abstract: We encountered a 55-year-old female patient with Hashimoto's thyroiditis who showed persistent fever, and could not find any source of fever other than the large nontender goiter. Her fever continued with positive CRP for 6 months. Although we did not assume that the inflammation was related to Hashimoto's thyroiditis, total thyroidectomy was performed for cosmetic reasons; however, fever was resolved immediately after thyroidectomy. Pathological diagnosis was Hashimoto's chronic thyroiditis. Immunohistochemical staining showed that the follicular cells were positive for IL-1alpha, IL-1beta, and TNF-alpha. We believed that fever was induced by inflammatory cytokines produced in thyroid. The case indicated that Hashimoto's thyroiditis with nontender goiter could cause idiopathic fever.
authors: Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe, 650-0011, Japan. kubota@kuma-h.or.jp
authors: Sumihisa
authors: S
authors: Kubota
authors: Fumio
authors: F
authors: Matsuzuka
authors: Hidemi
authors: H
authors: Ohye
authors: Eijun
authors: E
authors: Nishihara
authors: Takumi
authors: T
authors: Kudo
authors: Mitsuru
authors: M
authors: Ito
authors: Takeshi
authors: T
authors: Arishima
authors: Shuji
authors: S
authors: Fukata
authors: Mitsuyoshi
authors: M
authors: Hirokawa
authors: Nobuyuki
authors: N
authors: Amino
authors: Akira
authors: A
authors: Miyauchi
mesh_terms: D005260:Female; D005334:Fever / Q000209:etiology* / Q000601:surgery; D005355:Fibrosis; D006042:Goiter / Q000473:pathology; D050031:Hashimoto Disease / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D013961:Thyroid Gland / Q000473:pathology; D013965:Thyroidectomy
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