title: Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression.
abstract: OBJECTIVE
  We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions.
  
  
  METHODS
  We studied 217 older depressed patients and 141 individuals in the comparison group using a standard brain MRI protocol to calculate lesion volumes. Genotype at 5HTTLPR was determined for each subject.
  
  
  RESULTS
  In age-adjusted models, the l/s genotype was associated with increased volume of total and white-matter lesions among depressed patients. This relationship lost significance in models controlling for reported hypertension.
  
  
  CONCLUSIONS
  The finding that 5HTTLPR heterozygotes have higher vascular lesion volumes may be related to development of hypertension.
authors: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. steff001@mc.duke.edu
authors: David C
authors: DC
authors: Steffens
authors: Warren D
authors: WD
authors: Taylor
authors: Douglas R
authors: DR
authors: McQuoid
authors: K Ranga R
authors: KR
authors: Krishnan
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D003865:Major Depressive Disorder / Q000235:genetics* / Q000473:pathology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins