Logic of gene regulatory networks.
Regulatory networks of transcription factors and signaling molecules lie at the heart of development. Their architecture implements logic functions whose execution propels cells from one regulatory state to the next, thus driving development forward. As an example of a subcircuit that translates transcriptional input into developmental output, we consider a particularly simple case, the regulatory processes underlying pigment cell formation in sea urchin embryos. The regulatory events in this process can be represented as elementary logic functions.
Materna
Stefan C
SC
California Institute of Technology, Division of Biology, m/c 156-29, 1200 E. California Blvd., Pasadena, CA 91125, USA.
Davidson
Eric H
EH
D000818:Animals; D019070:Cell Lineage; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D012617:Sea Urchins / Q000166:cytology / Q000196:embryology* / Q000235:genetics
Dev Biol. 2002 Jun 1;246(1):162-90
12027441
Annu Rev Biophys Biomol Struct. 2007;36:191
17291181
Development. 2004 Mar;131(5):965-73
14973298
Development. 1996 Jan;122(1):253-63
8565837
Development. 1998 Sep;125(17):3269-90
9693132
Development. 1999 Apr;126(8):1703-13
10079232
Dev Biol. 2005 Mar 1;279(1):252-67
15708573
Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4954-9
15788531
Dev Biol. 2005 Jul 1;283(1):1-16
15907831
Dev Cell. 2005 Oct;9(4):449-62
16198288
Dev Genes Evol. 2005 Nov;215(11):580-96
16252120
Dev Biol. 2006 Sep 15;297(2):587-602
16925988
Development. 2006 Nov;133(21):4173-81
17038513
Dev Biol. 2006 Dec 1;300(1):153-64
17067570
Dev Biol. 2006 Dec 1;300(1):27-34
17101125
Science. 2007 Mar 16;315(5818):1510-1
17363653
BMC Syst Biol. 2007;1:11
17408501
Development. 2003 Oct;130(19):4587-96
12925586