title: Long-term morphological changes in a cryopreserved pulmonary valve homograft.
abstract: Pulmonary homografts (PHs) are frequently used to replace the native pulmonary valve in the Ross procedure, and in the reconstruction of the right ventricular outflow tract. The case of a 25-year-old man whose PH was replaced 12 years after undergoing the Ross procedure is reported. The clinical cause of the PH failure was stenosis. Morphological studies showed cusp tissue degeneration with tears and calcification, as well as pannus growth on the flow and nonflow surfaces of the cusps and the pulmonary artery graft. The durability of this PH was likely due to a combination of low pressure on the right side of the heart and the patient's age at surgery.
authors: Department of Pathology, Toronto General Hospital/University Health Network, Toronto, ON, Canada.
authors: Adriana
authors: A
authors: Luk
authors: Jagdish
authors: J
authors: Butany
authors: Sarah A
authors: SA
authors: Erlich
authors: Jessica
authors: J
authors: Henry
authors: Tirone E
authors: TE
authors: David
mesh_terms: D000328:Adult; D001022:Aortic Valve Insufficiency / Q000601:surgery; D015925:Cryopreservation; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D008297:Male; D011651:Pulmonary Artery / Q000473:pathology* / Q000601:surgery; D011664:Pulmonary Valve / Q000473:pathology* / Q000601:surgery / Q000637:transplantation; D012086:Reoperation; D013997:Time Factors; D014184:Transplantation, Homologous / Q000473:pathology*
references: Lancet. 1966 Dec 31;2(7479):1446-7
references: 4163445
references: Eur J Cardiothorac Surg. 1999 May;15(5):639-44; discussion 644-5
references: 10386410
references: Eur J Cardiothorac Surg. 2005 Jun;27(6):975-9
references: 15896604
references: Cardiovasc Pathol. 2004 Jan-Feb;13(1):59-61
references: 14761788
references: Circulation. 2000 Nov 7;102(19 Suppl 3):III130-5
references: 11082375
references: Ann Thorac Surg. 2001 Jan;71(1):54-9; discussion 59-60
references: 11216810
references: Cardiovasc Pathol. 2007 Sep-Oct;16(5):258-67
references: 17868876