Pharmacological studies on anti-hyperglycemic effect of folium eriobotryae.
Folium eriobotryae, dried leaves of Eriobotrya japonica (Thunb.) Lindl. is a traditional Chinese medicine with rich resources in China. This research investigated the anti-hyperglycemic effect of folium eriobotryae on normal and alloxan-diabetic mice. The 70% ethanol extract of folium eriobotryae (EJA-0) in doses of 15, 30 and 60 g (crude drug)/kg exerted a significant hypoglycemic effect on alloxan-diabetic mice, among which 30 g/kg of EJA-0 was more effective than 100 mg/kg of phenformin. The total sesquiterpenes (EJA-1) 30 g (crude drug)/kg had significant effect on lowering blood glucose level in normal or/and alloxan-diabetic mice. The tests of maximum dosage and acute toxicity showed that EJA-1 was safe (MD = 360 g/kg, LD(50) = 400.1 g/kg). The pharmacological tests on anti-hyperglycemic effects of EJA-0 and EJA-1 prove that folium eriobotryae is an outstanding material to develop medicine for treatment of diabetes mellitus.
Li
Wei-Lin
WL
Institute of Botany (Nanjing Botanical Garden, Mem. Sun Yet-sen), Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, Jiangsu, China. lwlcnbg@mail.cnbg.net
Wu
Ju-Lan
JL
Ren
Bing-Ru
BR
Chen
Jian
J
Lu
Chang-Gen
CG
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D031983:Eriobotrya; D005260:Female; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods; D051379:Mice; D008517:Phytotherapy / Q000379:methods; D018515:Plant Leaves; D011897:Random Allocation
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D000496:Alloxan