title: The value of gamma camera and computed tomography data set coregistration to assess Lewis Y antigen targeting in small cell lung cancer by (111)Indium-labeled humanized monoclonal antibody 3S193.
abstract: OBJECTIVE
  To assess the value of data set coregistration of gamma camera and computed tomography (CT) in the assessment of targeting of humanized monoclonal antibody 3S193 labeled with indium-111 ((111)In-hu3S193) to small cell lung cancer (SCLC).
  
  
  METHODS
  Ten patients (6 male and 4 female; mean age+/-S.D., 60+/-4 years), from an overall population of 20 patients with SCLCs expressing Lewis Y antigen at immunohistochemical analysis, completed a four weekly injections of (111)In-hu3S193 and underwent gamma camera imaging. All had had, as part of their baseline evaluation, Fluorine18 fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). Two readers in consensus retrospectively coregistered the gamma camera images with the CT component of the FDG PET/CT by automatic or manual alignment. The resulting image sets were visually examined and SCLC lesions targeting at coregistered gamma camera and CT was correlated side-by-side with the (18)F-FDG uptake.
  
  
  RESULTS
  A total number of 31 lesions from SCLC with a thoracic (n=13) or extrathoracic location (n=18) were all positive on FDG PET/CT. Coregistration of the gamma camera to the CT demonstrated targeting of antibody to all lesions >2 cm (n=20) and in a few lesions < or =2 cm (n=2), with no visualization of most lesions < or = 2 cm (n=9). No (111)In-hu3S193 uptake in normal tissues was observed.
  
  
  CONCLUSIONS
  Coregistration of antibody gamma camera imaging to FDG PET/CT is feasible and allows valuable assessment of (111)In-hu3S193 antibody targeting to SCLC lesions >2cm, while lesions < or =2 cm reveal a limited targeting.
authors: Department of Radiology, Cattinara Hospital, University of Trieste, Strada di Fiume 447, 34149 Trieste, Italy. Electronic address: quaia@units.it.
authors: Emilio
authors: E
authors: Quaia
authors: Thoracic Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors: Lee M
authors: LM
authors: Krug
authors: Nuclear Medicine Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors: Neeta
authors: N
authors: Pandit-Taskar
authors: Nuclear Medicine Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors: Andrew
authors: A
authors: Nagel
authors: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors: Victor E
authors: VE
authors: Reuter
authors: Nuclear Medicine Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors: John
authors: J
authors: Humm
authors: Division of Nuclear Medicine and Clinical Molecular Imaging, Hospital of the University of Pennsylvania, 3400 Spruce Street, Room Donner 116, Philadelphia, PA 19104, USA.
authors: Chaitanya
authors: C
authors: Divgi
mesh_terms: D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D005260:Female; D015902:Gamma Cameras; D049671:History, 18th Century; D006801:Humans; D007205:Indium Radioisotopes / Q000493:pharmacokinetics; D007983:Lewis Blood Group Antigens / Q000378:metabolism*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D016499:Radioimmunotherapy / Q000379:methods*; D011877:Radionuclide Imaging; D055752:Small Cell Lung Carcinoma / Q000000981:diagnostic imaging* / Q000276:immunology / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D051598:Whole Body Imaging
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; C522039:Hu3S193 monoclonal antibody; D007205:Indium Radioisotopes; D007983:Lewis Blood Group Antigens; C094162:Lewis Y antigen