title: Stress-induced downregulation of macrophage phagocytic function is attenuated by exercise training in rats.
abstract: OBJECTIVE
  Acute restraint stress may induce impaired macrophage phagocytic function. Moderate physical training is associated with beneficial effects on immunological functions. We investigated the effects of moderate physical training on phagocytic function of alveolar macrophages in rats submitted to acute restraint stress.
  
  
  METHODS
  Thirty male Wistar rats weighing 210-226 g were randomly divided into 4 groups: nontrained rats (n = 7), nontrained rats submitted to stress (n = 8), trained rats (n = 7) and trained rats submitted to stress (n = 8). Trained rats were submitted to a program of moderate running training over a period of 8 weeks. Rats subjected to restraint stress were kept immobilized in glass cylinders (8 cm in diameter and 24 cm long) during 60 min. Phagocytosis capacity of macrophages was evaluated by either Escherichia coli orzymosan stimuli.
  
  
  RESULTS
  Restraint stress induced a decrease in phagocytosis of E. coli and zymosan particle stimulation by macrophages. Neither of these alterations was observed in trained animals submitted to acute restraint stress.
  
  
  CONCLUSIONS
  Our data confirm that acute restraint stress is associated with impaired function of macrophages. Moreover, moderate physical training attenuates the effects of acute stress by a mechanism that involves an increase in tolerance of macrophages.
authors: Department of Nutrition, Federal University of Pernambuco, Recife, Brazil. carolleandro22@yahoo.com.br
authors: Carol Góis
authors: CG
authors: Leandro
authors: Thais Martins
authors: TM
authors: de Lima
authors: Tatiana Carolina
authors: TC
authors: Alba-Loureiro
authors: Elizabeth
authors: E
authors: do Nascimento
authors: Raul
authors: R
authors: Manhães de Castro
authors: Célia M M B
authors: CM
authors: de Castro
authors: Tania Cristina
authors: TC
authors: Pithon-Curi
authors: Rui
authors: R
authors: Curi
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D015536:Down-Regulation; D016676:Macrophages, Alveolar / Q000276:immunology*; D008297:Male; D015213:Neuroimmunomodulation; D010587:Phagocytosis / Q000276:immunology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000276:immunology* / Q000503:physiopathology