[Inhibitors of alpha-amylase from plants--a possibility to treat diabetes mellitus type II by phytotherapy?].
Antidiabetics of plant origin are in common use. A proof of their effectiveness or their mode of action is often missing. The aim of this work was to review the knowledge about inhibitors of alpha-amylase from plants and to comment on the use in anti-diabetic treatment. Herbal alpha-amylase inhibitors are rarely described in the literature, nevertheless they have the ability to lower postprandial blood glucose level and should be used in the supplementary treatment of diabetes. Important constituents for the inhibitory activity against alpha-amylase are mainly polyphenolic compounds. There is a need for further clinical studies to establish a rational therapy with traditional herbal preparations, especially for the leaves from the blueberry, tamarind, lemon balm and rosemary, the hulls from white kidney beans or green tea extract.
Melzig
Matthias F
MF
Institut für Pharmazie der Freien Universität Berlin, Berlin, Germany. melzig@zedat.fu-berlin.de
Funke
Ines
I
D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use; D028321:Plant Preparations / Q000008:administration & dosage / Q000627:therapeutic use; D010946:Plants, Medicinal; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
D007004:Hypoglycemic Agents; D010936:Plant Extracts; D028321:Plant Preparations; D000516:alpha-Amylases
J Nutr Sci Vitaminol (Tokyo). 2006 Apr;52(2):149-53
16802696
Nat Prod Res. 2006 Jul 20;20(9):882-6
16753927
J Ethnopharmacol. 1995 Mar;45(3):223-6
7623488
Asia Pac J Clin Nutr. 2006;15(3):425-32
16837437
Eur J Clin Invest. 1994 Aug;24 Suppl 3:3-10
8001624
Br J Nutr. 1991 Jul;66(1):139-47
1931901
Nutrition. 2005 Jun;21(6):756-61
15925302
Asia Pac J Clin Nutr. 2006;15(3):433-41
16837438
Diabetes Care. 1999 Jun;22(6):920-4
10372242
J Nutr. 2001 Jan;131(1):66-71
11208940
Carbohydr Res. 2004 Feb 25;339(3):715-7
15013410
Biofactors. 2005;23(4):189-95
16498205
J Biol Chem. 1975 Oct 25;250(20):8030-7
240849
Atherosclerosis. 1999 May;144(1):229-35
10381296
Pharmazie. 2005 Oct;60(10):796-7
16259133
Diabetes Care. 2003 Apr;26(4):1277-94
12663610
Asia Pac J Clin Nutr. 2004;13(1):101-6
15003922
Lancet. 2002 Jun 15;359(9323):2072-7
12086760
Biosci Biotechnol Biochem. 2002 Jul;66(7):1576-8
12224646
Asia Pac J Clin Nutr. 2006;15(1):107-18
16500886
Diabetes Care. 2003 Dec;26(12):3215-8
14633804
J Agric Food Chem. 2002 Jun 5;50(12):3566-71
12033830
J Clin Invest. 2001 Oct;108(8):1105-7
11602616
Mol Nutr Food Res. 2005 Aug;49(8):791-6
16007724
Curr Diab Rep. 2006 Jun;6(3):251-8
16898580
J Agric Food Chem. 2001 Sep;49(9):4208-13
11559112
Proc Nutr Soc. 1991 Dec;50(3):641-51
1809971