title: Significant correlation between cerebrospinal fluid nitric oxide concentrations and neurologic prognosis in incomplete cervical cord injury.
abstract: In animal models of spinal cord injury (SCI), inducible NO (nitric oxide) synthase is expressed in the spinal cord immediately after sustaining SCI. Excessive NO production has cytotoxic effects and induces neuronal apoptosis, causing neural degeneration and neurodysfunction in the spinal cord. Little is known, however, about the relationship between NO(x) (NO metabolites: nitrite and nitrate) levels in the cerebrospinal fluid (CSF) and neurologic severity or recovery in clinical cases. The objective of the present study was to examine the correlation between CSF NO(x) levels and neurologic severity or recovery in SCI. Twenty-five patients with incomplete cervical cord injury (CCI) were examined. Eight cases were treated conservatively (non-operated group). Seventeen cases underwent surgical intervention (operated group). NO(x) levels in the CSF were measured using the Griess method. The severity of the neurologic impairment was assessed using Frankel's classification and the American Spinal Injury Association motor score (ASIA MS). The degree of neurologic recovery was assessed using Frankel's classification and the ASIA motor recovery percentage (MRP). There was no significant difference in the NO(x) levels between the CCI group (NO(x) levels: 5.9 +/- 0.7 microM) and the 36 control subjects (1 volunteer and 35 patients without neurologic disorders, NO(x) levels: 4.9 +/- 0.3 microM). There was no significant difference in NO(x) levels and MRP between the non-operated group and the operated group. The NO(x) levels in total SCI group were significantly correlated with the ASIA MS and MRP. There was a significant correlation between CSF NO(x) levels and neurologic severity or recovery in incomplete CCI.
authors: Department of Orthopedic Surgery, Niigata Rousai Hospital, Joetsu City, Niigata, Japan.
authors: Noboru
authors: N
authors: Hosaka
authors: Shinji
authors: S
authors: Kimura
authors: Akiyoshi
authors: A
authors: Yamazaki
authors: Xianjun
authors: X
authors: Wang
authors: Hiroshi
authors: H
authors: Denda
authors: Takui
authors: T
authors: Ito
authors: Toru
authors: T
authors: Hirano
authors: Naoto
authors: N
authors: Endo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002574:Cervical Vertebrae / Q000293:injuries*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000134:cerebrospinal fluid*; D011379:Prognosis; D020127:Recovery of Function / Q000502:physiology; D013119:Spinal Cord Injuries / Q000134:cerebrospinal fluid* / Q000503:physiopathology / Q000601:surgery*; D015599:Trauma Severity Indices
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide
references: Arch Phys Med Rehabil. 1999 Nov;80(11):1391-6
references: 10569432
references: J Neurosci Methods. 2005 Jun 30;145(1-2):89-95
references: 15922028
references: Neurosci Lett. 1999 Nov 19;275(3):199-202
references: 10580709
references: Pain. 2001 Jun;92(3):363-71
references: 11376909
references: J Neurotrauma. 2001 May;18(5):523-32
references: 11393255
references: Comp Biochem Physiol A Mol Integr Physiol. 2001 Sep;130(2):271-82
references: 11544072
references: Spine (Phila Pa 1976). 2001 Dec 15;26(24 Suppl):S101-10
references: 11805616
references: Neuroscience. 2002;115(3):839-49
references: 12435422
references: J Neurotrauma. 2002 Nov;19(11):1467-74
references: 12490011
references: J Neurosurg Spine. 2004 Oct;1(3):311-21
references: 15478370
references: Paraplegia. 1969 Nov;7(3):179-92
references: 5360915
references: Biochem Biophys Res Commun. 1988 Nov 30;157(1):87-94
references: 3196352
references: J Neurosurg. 1991 Jul;75(1):15-26
references: 2045903
references: Pharmacol Rev. 1991 Jun;43(2):109-42
references: 1852778
references: J Neurosurg. 1992 Jan;76(1):23-31
references: 1727165
references: J Neurosci. 1993 Jun;13(6):2651-61
references: 7684776
references: Nature. 1993 Aug 12;364(6438):626-32
references: 8394509
references: Clin Chem. 1995 Jun;41(6 Pt 1):892-6
references: 7768008
references: Spine (Phila Pa 1976). 1996 Mar 1;21(5):614-9
references: 8852318
references: Free Radic Biol Med. 1996;20(1):1-9
references: 8903674
references: Neurosurgery. 1996 Nov;39(5):950-6; discussion 956-7
references: 8905750
references: Spine (Phila Pa 1976). 1996 Oct 15;21(20):2345-51
references: 8915069
references: Nat Med. 1997 Jan;3(1):73-6
references: 8986744
references: Spinal Cord. 1997 May;35(5):266-74
references: 9160449
references: J Neurosci. 1998 Feb 1;18(3):923-31
references: 9437014
references: J Neurosci. 1998 Nov 1;18(21):8551-8
references: 9786963
references: J Neurosurg. 1998 Dec;89(6):911-20
references: 9833815
references: Neurosurgery. 1999 Apr;44(4):785-92; discussion 792-3
references: 10201304
references: Neuroreport. 1999 Feb 5;10(2):275-9
references: 10203321
references: Spinal Cord. 2005 Mar;43(3):167-70
references: 15520837