Drug treatment improves memory in mice.
Mice that carry additional copies of genes comparable to those present on human chromosome 21 have been shown to perform better on memory tests when treated with drugs that target brain function. Could this be an important break-through in the search for pharmacological therapies to assist people with Down syndrome?
Buckley
Frank
F
The Down Syndrome Educational Trust, Portsmouth, Hampshire, UK. frank.buckley@downsed.org
Sacks
Ben
B
D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D002891:Chromosomes, Human, Pair 21; D003517:Cyclopentanes / Q000494:pharmacology; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D005663:Furans / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology*; D046934:Ginkgolides / Q000494:pharmacology; D006801:Humans; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008822:Mice, Transgenic; D009483:Neuropsychological Tests; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology
D000697:Central Nervous System Stimulants; D003517:Cyclopentanes; D005663:Furans; D018756:GABA Antagonists; D046934:Ginkgolides; D010433:Pentylenetetrazole; D010852:Picrotoxin; C073710:bilobalide