title: Asymmetries of cortical thickness: effects of handedness, sex, and schizophrenia.
abstract: Sex, handedness, and disease processes in schizophrenia may affect the magnitude and/or direction of structural brain asymmetries. Using MRI data from 67 healthy (30 men, 10 nondextral) and 84 schizophrenia patients (60 men, 16 nondextral), cortical thickness asymmetries were compared at high spatial resolution. Within-group asymmetries were observed in sensorimotor, perisylvian, and parahippocampal cortices (leftward) and in anterior mesial frontal cortices (rightward). Asymmetry patterns were similar across diagnosis and sex, although some regional asymmetry increases were observed in men. Hand preference (dextrality) significantly influenced regional asymmetries in parietal association and dorsomedial frontal cortices (false discovery rate-corrected), where medial-frontal regions showed diagnosis by dextrality effects (uncorrected). Thus, dextrality relates to cortical thickness asymmetries, although schizophrenia may differentially affect asymmetry patterns across handedness.
authors: Laboratory of NeuroImaging, Geffen School of Medicine at UCLA, Los Angeles, California 90095-7334, USA.
authors: Liberty S
authors: LS
authors: Hamilton
authors: Katherine L
authors: KL
authors: Narr
authors: Eileen
authors: E
authors: Luders
authors: Philip R
authors: PR
authors: Szeszko
authors: Paul M
authors: PM
authors: Thompson
authors: Robert M
authors: RM
authors: Bilder
authors: Arthur W
authors: AW
authors: Toga
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*; D012727:Sex Characteristics
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