miRNomics-The bioinformatics of microRNA genes.
MicroRNAs (miRNAs) are tiny genetic rheostats in plants, animals, and viruses, regulating the expression of messenger RNAs by targeting transcripts for cleavage or translational repression. Their regulatory impact is even more pervasive as a potential therapeutic tool. Since inception, computational methods have been an invaluable tool complementing experimental approaches. Here, we outline miRNA-bioinformatics highlighting the biological and therapeutic repertoire of miRNAs, in silico prediction of miRNA genes and their targets, along with a glimpse of the bioinformatic challenges that lie ahead.
Ghosh
Zhumur
Z
Computational Biology Group, Indian Association for the Cultivation of Science, 2A & 2B, Raja S.C. Mullick Road, Jadavpur, Calcutta 700032, India.
Chakrabarti
Jayprokas
J
Mallick
Bibekanand
B
D000818:Animals; D019295:Computational Biology / Q000639:trends*; D005786:Gene Expression Regulation / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics*; D008957:Models, Genetic; D009024:Morphogenesis / Q000235:genetics*; D013329:Structure-Activity Relationship
D035683:MicroRNAs