title: Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys.
abstract: A strain of Plasmodium falciparum from Peru was adapted to splenectomized Aotus nancymaae and Aotus vociferans monkeys. The Peru 134/CDC strain of P. falciparum was shown to be resistant to treatment with chloroquine in monkeys and partially resistant to mefloquine and malarone. Genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this Peruvian strain of P. falciparum.
authors: Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention/USPHS/DHHS, 4770 Buford Highway, Chamblee, GA 30341, USA. wec1@cdc.gov
authors: William E
authors: WE
authors: Collins
authors: Joann S
authors: JS
authors: Sullivan
authors: Patrice
authors: P
authors: Hall
authors: Trenton K
authors: TK
authors: Ruebush
authors: Allison
authors: A
authors: Williams
authors: Katharine K
authors: KK
authors: Grady
authors: Amy
authors: A
authors: Bounngaseng
authors: Douglas
authors: D
authors: Nace
authors: Tyrone
authors: T
authors: Williams
authors: Curtis
authors: C
authors: Huber
authors: G Gale
authors: GG
authors: Galland
authors: John W
authors: JW
authors: Barnwell
authors: James J
authors: JJ
authors: Sullivan
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use; D016645:Aotidae; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use; D045303:Cytochromes b / Q000235:genetics; D016054:DNA, Protozoan / Q000737:chemistry / Q000235:genetics; D004094:Dihydropteroate Synthase / Q000235:genetics; D004195:Disease Models, Animal; D018432:Drug Resistance, Multiple / Q000235:genetics; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology*; D015767:Mefloquine / Q000494:pharmacology / Q000627:therapeutic use; D008992:Monkey Diseases / Q000188:drug therapy / Q000469:parasitology*; D018512:Parasitemia / Q000188:drug therapy / Q000469:parasitology; D010568:Peru; D010963:Plasmodium falciparum / Q000201:enzymology / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D017422:Sequence Analysis, DNA; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics
chemical_list: D000962:Antimalarials; D016054:DNA, Protozoan; D002738:Chloroquine; D045303:Cytochromes b; D013762:Tetrahydrofolate Dehydrogenase; D004094:Dihydropteroate Synthase; D015767:Mefloquine