In vivo bactericidal activities of Japanese rice-fluid against H. pylori in a Mongolian gerbil model.
OBJECTIVE
The antibiotic effect of rice-fluid on Helicobacter pylori infection was investigated using a Mongolian gerbil model.


METHODS
Gerbils were divided into four groups: H. pylori -infected, rice-fluid-treated animals (group A); H. pylori -infected, untreated animals (group B); uninfected, rice-fluid-treated animals (group C); and uninfected, untreated animals (group D). Group A and B animals were killed 14 weeks after H. pylori infection and group C and D animals were killed at the same age. The stomachs were examined for histology, 5'-bromo-2'-deoxyuridine (BrdU) labeling, and the bacterial burden. Serum anti-H. pylori antibody titers were also tested.


RESULTS
The positive incidence of H. pylori -culture was 25 and 84 % in groups A and B, respectively (p<0.01). Both the degree of inflammation and the BrdU labeling index in group A were significantly lower than those in group B.


CONCLUSIONS
Rice-fluid showed an antibiotic effect on H. pylori and an anti-inflammatory effect on the H. pylori -associated gastritis.
Ishizone
Satoshi
S
Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan. ishizone@hsp.md.shinshu-u.ac.jp
Maruta
Fukuto
F
Suzuki
Kazufumi
K
Miyagawa
Shinichi
S
Takeuchi
Masahiko
M
Kanaya
Kiyomi
K
Oana
Kozue
K
Hayama
Masayoshi
M
Kawakami
Yoshiyuki
Y
Ota
Hiroyoshi
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D004195:Disease Models, Animal; D005756:Gastritis / Q000382:microbiology / Q000517:prevention & control*; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000473:pathology / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000187:drug effects*; D012275:Oryza / Q000737:chemistry*; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D028321:Plant Preparations
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