Understanding FOXP3: progress towards achieving transplantation tolerance.
Regulatory T cells (Treg) suppress immune responses, making them an exciting therapeutic target for achieving operational transplant tolerance. Recent observations have identified forkhead box P3 (FOXP3) as a master gene required for the development and function of Treg. Improving our understanding of FOXP3 may facilitate methods for identifying and generating Treg.
Long
Elaine
E
Transplant Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom. elaine.long@nds.ox.ac.uk
Wood
Kathryn J
KJ
D051858:Forkhead Transcription Factors / Q000502:physiology*; D006801:Humans; D016377:Organ Transplantation / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology; D023001:Transplantation Tolerance / Q000502:physiology*
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors