title: Ulex europeus agglutinin-I binding as a potential prognostic marker in ovarian cancer.
abstract: BACKGROUND
  Ovarian cancer represents the malignant tumour of the female genital tract with the worst prognosis, mainly caused by early intraperitoneal spread. Cell-to-cell and cell-to-matrix interactions play a functionally important role in this spread and are both mediated by the cell membrane. Changes in the glycosylation of the cell membrane, as detected by lectin histochemistry, are sometimes associated with a poor prognosis.
  
  
  METHODS
  The expression of lectin binding of 164 ovarian cancer patients was analysed and the staining results were correlated with the clinical data of the patients.
  
  
  RESULTS
  The univariate and multivariate statistical analysis revealed an independent prognostic significance for Ulex europeus agglutinin-I (UEA-I) binding.
  
  
  CONCLUSIONS
  These findings indicate that UEA-I binding can serve as a prognostic factor in ovarian cancer.
authors: Department of Anatomy II. Experimental Morphology, University Medical Center Hamburg-Eppendorf 20246 Hamburg, Germany.
authors: Katharina
authors: K
authors: Blonski
authors: Karin
authors: K
authors: Milde-Langosch
authors: Ana-Maria
authors: AM
authors: Bamberger
authors: Tina
authors: T
authors: Osterholz
authors: Christian
authors: C
authors: Utler
authors: Jürgen
authors: J
authors: Berger
authors: Thomas
authors: T
authors: Löning
authors: Udo
authors: U
authors: Schumacher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001665:Binding Sites; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D037121:Plant Lectins / Q000378:metabolism*; D011379:Prognosis; D013194:Staining and Labeling / Q000379:methods
chemical_list: D037121:Plant Lectins; C036850:Ulex europaeus lectins