Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment.
The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.
Tfelt-Hansen
P
P
Danish Headache Centre, Depatment of Neurology, Glostrup Hospital, DK-2600 Glostrup, Denmark. tfelt@inet.uni2.dk
Edvinsson
L
L
D001682:Biological Availability; D002536:Cerebral Arteries / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*; D017366:Serotonin Receptor Agonists / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*
D017366:Serotonin Receptor Agonists