title: Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42.
abstract: Bacillus amyloliquefaciens FZB42 is a Gram-positive, plant-associated bacterium, which stimulates plant growth and produces secondary metabolites that suppress soil-borne plant pathogens. Its 3,918-kb genome, containing an estimated 3,693 protein-coding sequences, lacks extended phage insertions, which occur ubiquitously in the closely related Bacillus subtilis 168 genome. The B. amyloliquefaciens FZB42 genome reveals an unexpected potential to produce secondary metabolites, including the polyketides bacillaene and difficidin. More than 8.5% of the genome is devoted to synthesizing antibiotics and siderophores by pathways not involving ribosomes. Besides five gene clusters, known from B. subtilis to mediate nonribosomal synthesis of secondary metabolites, we identified four giant gene clusters absent in B. subtilis 168. The pks2 gene cluster encodes the components to synthesize the macrolactin core skeleton.
authors: Bakteriengenetik, Institut für Biologie, Humboldt Universität, Chausseestrasse 117, D-10115 Berlin, Germany.
authors: Xiao Hua
authors: XH
authors: Chen
authors: Alexandra
authors: A
authors: Koumoutsi
authors: Romy
authors: R
authors: Scholz
authors: Andreas
authors: A
authors: Eisenreich
authors: Kathrin
authors: K
authors: Schneider
authors: Isabelle
authors: I
authors: Heinemeyer
authors: Burkhard
authors: B
authors: Morgenstern
authors: Björn
authors: B
authors: Voss
authors: Wolfgang R
authors: WR
authors: Hess
authors: Oleg
authors: O
authors: Reva
authors: Helmut
authors: H
authors: Junge
authors: Birgit
authors: B
authors: Voigt
authors: Peter R
authors: PR
authors: Jungblut
authors: Joachim
authors: J
authors: Vater
authors: Roderich
authors: R
authors: Süssmuth
authors: Heiko
authors: H
authors: Liesegang
authors: Axel
authors: A
authors: Strittmatter
authors: Gerhard
authors: G
authors: Gottschalk
authors: Rainer
authors: R
authors: Borriss
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000235:genetics; D001407:Bacillus / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D004269:DNA, Bacterial; D005798:Genes, Bacterial; D016680:Genome, Bacterial / Q000235:genetics*; D006790:Host-Parasite Interactions; D008969:Molecular Sequence Data; D005810:Multigene Family; D010572:Pest Control, Biological; D063245:Plant Development; D010944:Plants / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D017262:Siderophores / Q000235:genetics
chemical_list: D023181:Antimicrobial Cationic Peptides; D004269:DNA, Bacterial; D017262:Siderophores