A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein.
This overview on the brain-serum relationship for drugs illustrates the importance of the drug transporter P-glycoprotein at the blood-brain barrier. Generally, an inverse relationship exists between the magnitude of the brain-serum ratio and the influence of P-glycoprotein. Concerning the pharmacogenomics of P-glycoprotein, no clear effect of single nucleotide polymorphisms (SNPs) has been demonstrated in humans.
Ejsing
Thomas Broeng
TB
Section of Forensic Chemistry, Institute of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark.
Morling
Niels
N
Linnet
Kristian
K
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism*; D001921:Brain; D006801:Humans; D051379:Mice; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism; D010599:Pharmacokinetics; D051381:Rats; D013329:Structure-Activity Relationship
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004364:Pharmaceutical Preparations