title: Organocatalytic and highly enantioselective direct alpha-amination of aromatic ketones.
abstract: The first highly enantioselective direct alpha-amination of aryl ketones was reported to be catalyzed by organic primary amines derived from cinchona alkaloids. Excellent enantioselectivities (88-99% ee) have been achieved for a broad spectrum of aryl ketones. The presence of 4 A molecular sieves was of great assistance for the high conversions and enantiocontrol.
authors: Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, and State Key Laboratory of Biotherapy, West China Hospital, Chengdu, China.
authors: Tian-Yu
authors: TY
authors: Liu
authors: Hai-Lei
authors: HL
authors: Cui
authors: Yan
authors: Y
authors: Zhang
authors: Kun
authors: K
authors: Jiang
authors: Wei
authors: W
authors: Du
authors: Zhao-Quan
authors: ZQ
authors: He
authors: Ying-Chun
authors: YC
authors: Chen
mesh_terms: D000586:Amination; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D006841:Hydrocarbons, Aromatic; D007659:Ketones; D009930:Organic Chemicals