title: Amino acid substitutions in the VP7 protein of human rotavirus G3 isolated in China, Russia, Thailand, and Vietnam during 2001-2004.
abstract: The distribution of rotavirus G-types in the world appears to be changing, especially with the emergence of G3 and G9 in many countries. Sequence analysis of the VP7 gene was performed on the 27 human G3 rotavirus strains isolated in China, Russia, Thailand, and Vietnam during 2001-2004. All the strains studied were clustered into the same branch of the phylogenetic tree. The comparison of the G3 deduced amino acid sequences between the studied Chinese strains and the strains circulating in China during 1986-1992 showed a wide range of amino acid substitutions (up to 13 amino acids in the VP7 antigenic regions). The two considerable changes both from aspartic acid to asparagine were located at positions 96 in antigenic region A and 213 in antigenic region C. Those amino acid substitutions of the Chinese G3 strains might involve in the emergence of G3 rotavirus in China during 2001-2003.
authors: Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Quang Duy
authors: QD
authors: Trinh
authors: Ngan Thi Kim
authors: NT
authors: Pham
authors: Tuan Anh
authors: TA
authors: Nguyen
authors: Tung Gia
authors: TG
authors: Phan
authors: Pattara
authors: P
authors: Khamrin
authors: Hainian
authors: H
authors: Yan
authors: Phuc Le
authors: PL
authors: Hoang
authors: Niwat
authors: N
authors: Maneekarn
authors: Yan
authors: Y
authors: Li
authors: Vladimir
authors: V
authors: Kozlov
authors: Alexei
authors: A
authors: Kozlov
authors: Shoko
authors: S
authors: Okitsu
authors: Hiroshi
authors: H
authors: Ushijima
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000956:Antigens, Viral / Q000235:genetics*; D036022:Capsid Proteins / Q000235:genetics*; D002681:China; D005814:Genes, Viral; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012401:Rotavirus / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000821:virology*; D016415:Sequence Alignment; D012800:Siberia; D013785:Thailand; D014744:Vietnam
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus