Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomes.
The pathways that deliver newly synthesized proteins that reside in lysosomes are well understood on comparison with our knowledge of how integral membrane proteins are sorted and delivered to the lysosome for degradation. Many membrane proteins are sorted to lysosomes following ubiquitination, which provides a sorting signal that can operate for sorting at the TGN (trans-Golgi network), at the plasma membrane or at the endosome for delivery into lumenal vesicles. Candidate multicomponent machines that can potentially move ubiquitinated integral membrane cargo proteins have been identified, but much work is still required to ascertain which of these candidates directly recognize ubiquitinated cargo and what they do with cargo after recognition. In the case of the machinery required for sorting into the lumenal vesicles of endosomes, other functions have also been determined including a link between sorting and movement of endosomes along microtubules.
Piper
Robert C
RC
Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Luzio
J Paul
JP
D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D011992:Endosomes / Q000502:physiology; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D025801:Ubiquitin / Q000502:physiology*
D008565:Membrane Proteins; D025801:Ubiquitin
Traffic. 2006 Mar;7(3):282-97
16497223
Mol Cell. 2006 Mar 17;21(6):737-48
16543144
Biochem J. 2006 Nov 1;399(3):361-72
17034365
Nat Cell Biol. 2006 Nov;8(11):1246-54
17013377
EMBO J. 2000 Jan 17;19(2):187-98
10637223
EMBO J. 2001 Feb 15;20(4):683-93
11179213
J Cell Biol. 2001 May 14;153(4):649-62
11352928
Cell. 2001 Jul 27;106(2):145-55
11511343
Traffic. 2001 Sep;2(9):612-21
11555415
EMBO J. 2001 Sep 17;20(18):5176-86
11566881
J Cell Sci. 2001 Oct;114(Pt 19):3413-8
11682601
Curr Biol. 2001 Oct 30;11(21):1680-5
11696325
J Biol Chem. 2001 Nov 23;276(47):43949-57
11500494
Nat Cell Biol. 2002 Feb;4(2):117-23
11788821
Mol Biol Cell. 2002 Apr;13(4):1313-28
11950941
Nat Cell Biol. 2002 May;4(5):394-8
11988743
Nat Cell Biol. 2002 Jul;4(7):534-9
12055639
Nat Rev Mol Cell Biol. 2002 Dec;3(12):893-905
12461556
J Biol Chem. 2003 Apr 4;278(14):12513-21
12551915
Nat Cell Biol. 2003 May;5(5):461-6
12717448
Mol Membr Biol. 2003 Apr-Jun;20(2):141-54
12851071
Mol Cell Biol. 2003 Sep;23(18):6494-506
12944476
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14908-13
14657369
J Biol Chem. 2003 Dec 26;278(52):52865-72
14563850
Mol Biol Cell. 2004 Feb;15(2):883-95
14657252
Nat Cell Biol. 2004 Mar;6(3):244-51
15039775
Nat Rev Mol Cell Biol. 2004 Apr;5(4):317-23
15071556
Curr Biol. 2004 May 4;14(9):R357-9
15120092
J Biol Chem. 2004 Jun 4;279(23):24435-43
15047686
Genes Dev. 2004 Jul 15;18(14):1737-52
15256501
EMBO J. 1994 Jul 15;13(14):3261-71
8045256
Cell. 1996 Jan 26;84(2):277-87
8565073
J Biol Chem. 1998 Aug 14;273(33):21408-15
9694904
J Cell Sci. 1999 Feb;112 ( Pt 3):317-27
9885285
Curr Biol. 2005 Feb 22;15(4):360-5
15723798
Cell. 2005 May 6;121(3):437-50
15882625
Dev Cell. 2005 Jul;9(1):63-73
15992541
J Cell Sci. 2005 Jul 15;118(Pt 14):3003-17
16014378
Cell. 2005 Sep 9;122(5):735-49
16143105
Trends Plant Sci. 2006 Mar;11(3):115-23
16488176
EMBO J. 2006 Apr 19;25(8):1635-45
16601694
Annu Rev Biophys Biomol Struct. 2006;35:277-98
16689637
Mol Biol Cell. 2006 Jun;17(6):2513-23
16554368
Trends Cell Biol. 2006 Jun;16(6):317-26
16716591
Mol Biol Cell. 2006 Aug;17(8):3469-83
16707569
Biochem Biophys Res Commun. 2006 Sep 8;347(4):1074-9
16857164
Nat Cell Biol. 2006 Aug;8(8):834-42
16862145
J Virol. 2006 Oct;80(19):9465-80
16973552
Biochem Biophys Res Commun. 2006 Nov 10;350(1):82-90
16996030
Biochem Biophys Res Commun. 2006 Nov 17;350(2):413-23
17010938
Mol Cell. 2005 Oct 28;20(2):301-12
16246731
Mol Biol Cell. 2005 Dec;16(12):5480-92
16176980
Biochem Biophys Res Commun. 2006 Mar 3;341(1):143-9
16412388
Nat Struct Mol Biol. 2006 Nov;13(11):1031-2
17057714
Nat Struct Mol Biol. 2006 Nov;13(11):1029-30
17057716
Curr Biol. 2006 Nov 21;16(22):2265-70
17113392
J Cell Biol. 2006 Nov 20;175(4):631-45
17116753
Nat Cell Biol. 2007 Jan;9(1):113-20
17173037
Science. 2007 Jan 12;315(5809):201-5
17218518
Nature. 2007 Feb 1;445(7127):554-8
17268469
J Cell Sci. 2007 Feb 15;120(Pt 4):543-53
17287393
J Cell Biol. 2007 Feb 12;176(4):459-71
17283181
Nat Cell Biol. 2006 Feb;8(2):163-9
16429130
Mol Cell Biol. 2006 Mar;26(5):1932-47
16479011
J Biol Chem. 2006 Feb 24;281(8):5094-105
16371348
Traffic. 2006 Mar;7(3):262-81
16497222