title: Cinchona alkaloids/TMAF combination-catalyzed nucleophilic enantioselective trifluoromethylation of aryl ketones.
abstract: The catalytic, nucleophilic enantioselective trifluoromethylation reaction of both acyclic and cyclic aryl ketones using the Ruppert-Prakash reagent is now at hand, with an operationally simple procedure, based on the combination of ammonium bromide of cinchona alkaloids with TMAF. The procedure is reliable and general. Trifluoromethyl-substituted tetrasubstituted aryl alcohols have been synthesized in up to 94% ee.
authors: Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
authors: Satoshi
authors: S
authors: Mizuta
authors: Norio
authors: N
authors: Shibata
authors: Surendar
authors: S
authors: Akiti
authors: Hiroyuki
authors: H
authors: Fujimoto
authors: Shuichi
authors: S
authors: Nakamura
authors: Takeshi
authors: T
authors: Toru
mesh_terms: D002384:Catalysis; D002626:Chemistry, Pharmaceutical; D002930:Cinchona Alkaloids / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002930:Cinchona Alkaloids; D007659:Ketones; D000644:Quaternary Ammonium Compounds; C027917:tetramethylammonium