Cell signaling arising from nanotopography: implications for nanomedical devices.
This review discusses the roles in signaling to cells by nanochemical, nanostructural (nanotopography) and mechanical means, as well as recent work and trends in nanobioscience that are relevant to therapeutic applications. It is suggested that the mechanical results may often integrate the other two types of signal. Although the field is still in an almost embryonic but rapidly developing state, it is possible to envisage potential medical devices. Nanoparticle-based therapies are recognized as having some appreciable hazards, while those based on extended nanofeatured surfaces probably have fewer risks.
Curtis
Adam S G
AS
University of Glasgow, Centre for Cell Engineering, Division of Infection & Immunity, Institute of Biomedical & Life Science, Glasgow, UK. a.curtis@bio.gla.ac.uk
Dalby
Matthew
M
Gadegaard
Nikolaj
N
D000818:Animals; D006801:Humans; D050997:Nanomedicine / Q000379:methods / Q000639:trends; D053758:Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction
D011956:Receptors, Cell Surface