title: Increased bone mineral density in aged rats with spontaneous mammary dysplasia.
abstract: Spontaneous mammary tumors were seen in seven of the 12 breeding female rats aged 2 years. All mammary tumors were diagnosed as mammary dysplasia (MD). Bone mineral contents (BMC) and bone mineral density (BMD) of their lumbar vertebrae and femur were determined using dual energy X-ray absorptiometry (DXA). In rats with MD, body weight (BW), BMD of the lumbar vertebrae and BMC of the femur were significantly higher than in the rats without MD. Although corpus luteum (CL) and follicles were seen in the ovaries of all animals, the number of CL in rats with MD was significantly lower than the rats without MD. It was suggested that high BMD, BW and decreased CL promoted mammary tumors.
authors: Department of Tumor Pathology, Field of Oncology, Kagoshima University, Graduate School of Medical and Dental Science, Kagoshima, Japan. kawa@m3.kufm.kagoshima-u.ac.jp
authors: Hiroaki
authors: H
authors: Kawaguchi
authors: Yoshihisa
authors: Y
authors: Umekita
authors: Masakazu
authors: M
authors: Souda
authors: Kentaro
authors: K
authors: Gejima
authors: Hideo
authors: H
authors: Kawashima
authors: Hiroshi
authors: H
authors: Maeda
authors: Hiroaki
authors: H
authors: Miyajima
authors: Ryoichi
authors: R
authors: Nagata
authors: Hiroki
authors: H
authors: Yoshida
mesh_terms: D015502:Absorptiometry, Photon; D000375:Aging / Q000502:physiology*; D000818:Animals; D001835:Body Weight; D015519:Bone Density / Q000502:physiology*; D003338:Corpus Luteum / Q000033:anatomy & histology / Q000502:physiology; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000502:physiology; D005348:Fibrocystic Breast Disease / Q000209:etiology* / Q000503:physiopathology*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000502:physiology; D009929:Organ Size; D006080:Ovarian Follicle / Q000033:anatomy & histology / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley