Synthesis, reaction and structure of a highly light-stable silver(I) cluster with an Ag4S4N4 core having a tridentate 4N-morpholyl 2-acetylpyridine thiosemicarbazone ligand: use of water-soluble silver(I) carboxylates as a silver(I) source.
A novel neutral tetrameric silver(I) cluster [Ag(mtsc)](4) was obtained from reactions of a tridentate (4)N-morpholyl 2-acetylpyridine thiosemicarbazone ligand (N'-[1-(2-pyridyl)ethylidene] morpholine-4-carbothiohydrazide, Hmtsc) and silver(I) sources containing Ag-O bonds (Ag(2)O, Ag(OAc), silver(I) 2-pyrrolidone-5-carboxylate (infinity){[Ag(Hpyrrld)](2)}, silver(I) 5-oxo-2-tetrahydrofurancarboxylate (infinity){[Ag(othf)](2)}, and silver(I) complexes with camphanic acid (infinity){[Ag(ca)]} and (infinity){[Ag(ca)(Hca)]}). The cluster was characterized by elemental analysis, TG/DTA, FTIR and single-crystal X-ray analysis in the solid state. The solution properties of the complexes were investigated using solution molecular weight measurement, ESI-MS and solution ((1)H, (13)C and (31)P) NMR spectroscopy. The obtained cluster is a novel example of a light-stable Ag(I) cluster with a tridentate thiosemicarbazone ligand and the second report of a crystal structure of a thiosemicarbazone silver(I) complex. The reaction of the tetramer with a large excess of PPh(3) gave dimeric complexes, namely, [Ag(micro(S)-mtsc)(PPh(3))](2) and [(PPh(3))(2)Ag(micro(S)-mtsc)(2)Ag]. The chloroform solution of the tetrameric complex showed modest and effective activities against selected bacteria (Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa) and yeasts (Candida albicans and Saccharomyces cerevisiae), respectively, but it did not inhibit the growth of any selected microorganisms in a water-suspension system.
Onodera
Kuniaki
K
Department of Materials Science, Faculty of Science, Kanagawa University, Hiratsuka, Kanagawa 259-1293, Japan.
Kasuga
Noriko Chikaraishi
NC
Takashima
Tomomi
T
Hara
Akihiro
A
Amano
Akifumi
A
Murakami
Hideyuki
H
Nomiya
Kenji
K
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D052160:Benzothiazoles; D001952:Bridged-Ring Compounds / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D002725:Chloroform / Q000737:chemistry; D018360:Crystallography, X-Ray; D004355:Drug Stability; D005658:Fungi / Q000187:drug effects; D007783:Lactones / Q000737:chemistry; D008024:Ligands; D008027:Light; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012834:Silver / Q000737:chemistry*; D012995:Solubility; D012996:Solutions / Q000737:chemistry; D013882:Thiosemicarbazones / Q000737:chemistry*; D014867:Water / Q000737:chemistry
C524577:4N-morpholyl 2-acetylpyridine thiosemicarbazone; D000900:Anti-Bacterial Agents; D052160:Benzothiazoles; D001952:Bridged-Ring Compounds; D002264:Carboxylic Acids; D007783:Lactones; D008024:Ligands; D009025:Morpholines; D009942:Organometallic Compounds; D012996:Solutions; D013882:Thiosemicarbazones; C500772:camphanic acid; D014867:Water; D012834:Silver; D002725:Chloroform; C032753:N-oxydiethylene-2-benzothiazole sulfenamide