[Fullerenes in biology].
Fullerenes are chemical structures made of carbon atoms. The stable form is molecule composed of 60 carbon atoms arranged in a soccer ball-shaped structure. With respect to its electron donor and acceptor capability and photochemical behavior fullerenes can be effective antioxidants and radical scavengers or prooxidants and photosensitizers. These properties of fullerenes have paid attention on their possible biological applications. Results of previous studies point to the great dependance of fullerenes activity upon quality, quantity and geometry of substituents in fullerene derivatives. Some of fullerene derivatives show antiviral and antimicrobial activity, including anti-HIV properties. C60 and its derivatives are able to exhibit cytotoxic and enzyme-inhibiting abilities as well as radical-quenching and antioxidative abilities. Generation of reactive oxygen species under influence of visible light is another ability of fullerene derivetives desired in photodynamic therapy.
Krokosz
Anita
A
Zakład Radiobiologii, Katedra Biofizyki Molekularnej, Uniwersytet Lódzki, Lódź. krokosz@biol.uni.lodz.pl
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry* / Q000494:pharmacology*; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology*; D016877:Oxidants / Q000737:chemistry / Q000494:pharmacology; D010084:Oxidation-Reduction; D010777:Photochemistry / Q000379:methods; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D000998:Antiviral Agents; D037741:Fullerenes; D016877:Oxidants; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; C408042:fullerol C60(OH)24; D002244:Carbon