title: Carotid artery distensibility: a reliability study.
abstract: OBJECTIVE
  Carotid distensibility (CD) is a measure of carotid artery elasticity that has been introduced as a risk factor for cardiovascular disease. Information regarding reproducibility of sonographic CD measures is limited. The objective of this study was to evaluate the inter-reader reliability of sonographic measurements of common carotid artery (CCA) diameters and derived metrics of CD.
  
  
  METHODS
  Two independent readers (R1 and R2) measured the systolic diameter (SD) and diastolic diameter (DD) for the right CCA from the B/M-mode sonographic registrations among 118 subjects. The derived CD metrics (strain, elastic modulus [E], stiffness [beta], and CD) were calculated. The inter-reader type 3 intraclass correlation coefficients (ICC3,1) for carotid diameters were calculated.
  
  
  RESULTS
  The mean SDs +/- standard deviation were 7.15 +/- 1.43 mm for R1 and 7.24 +/- 1.43 mm for R2. The mean DDs were 6.71 +/- 1.36 mm for R1 and 6.68 +/- 1.41 mm for R2. The mean differences of SD and DD between R1 and R2 were 0.08 +/- 0.40 mm (paired t test, P = .04) and 0.03 +/- 0.43 mm (paired t test, P = .46), respectively. Inter-reader type 3 intraclass correlation coefficients were 0.96 for SD and 0.95 for DD. We observed a significant association of demographics with carotid diameters but not with derived CD metrics or risk factors.
  
  
  CONCLUSIONS
  Our results suggest good reproducibility of CCA diameters measured with B/M-mode sonography. However, very small changes in linear measurements of carotid diameters can have big effects on estimates of arterial mechanical properties such as strain and Young's modulus. The standard boundary identification methods may not be precise and reproducible enough for use in a clinical setting.
authors: Department of Neurology, Division of Stroke, Columbia University and Mailman School of Public Health, New York, New York, USA.
authors: Elisa Cuadrado
authors: EC
authors: Godia
authors: Rishi
authors: R
authors: Madhok
authors: John
authors: J
authors: Pittman
authors: Samuel
authors: S
authors: Trocio
authors: Romel
authors: R
authors: Ramas
authors: Digna
authors: D
authors: Cabral
authors: Ralph L
authors: RL
authors: Sacco
authors: Tatjana
authors: T
authors: Rundek
mesh_terms: D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D003971:Diastole; D004548:Elasticity; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D015203:Reproducibility of Results; D013599:Systole; D014463:Ultrasonography
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