High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age.
Increased signaling of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) elicits apoptosis of skeletal muscle cells in various animal models. Within a population-based prospective follow up study of elderly people aged 85 years we show that a high innate production capacity of TNF-alpha precedes a steeper decline in muscle strength over time.
Taekema
Diana G
DG
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. d.g.taekema@lumc.nl
Westendorp
Rudi G J
RG
Frölich
Marijke
M
Gussekloo
Jacobijn
J
D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000276:immunology; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D018737:Hand Strength; D006801:Humans; D007113:Immunity, Innate; D007378:Interleukins / Q000097:blood; D008297:Male; D018908:Muscle Weakness / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D011446:Prospective Studies; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein