title: Molecular machinery of mitochondrial dynamics in yeast.
abstract: Mitochondria are amazingly dynamic organelles. They continuously move along cytoskeletal tracks and frequently fuse and divide. These processes are important for maintenance of mitochondrial functions, for inheritance of the organelles upon cell division, for cellular differentiation and for apoptosis. As the machinery of mitochondrial behavior has been highly conserved during evolution, it can be studied in simple model organisms, such as yeast. During the past decade, several key components of mitochondrial dynamics have been identified and functionally characterized in Saccharomyces cerevisiae. These include the mitochondrial fusion and fission machineries and proteins required for maintenance of tubular shape and mitochondrial motility. Taken together, these findings reveal a comprehensive picture that shows the cellular processes and molecular components required for mitochondrial inheritance and morphogenesis in a simple eukaryotic cell.
authors: Institut für Zellbiologie, Universität Bayreuth, D-95440 Bayreuth, Germany.
authors: Sandra
authors: S
authors: Merz
authors: Miriam
authors: M
authors: Hammermeister
authors: Katrin
authors: K
authors: Altmann
authors: Mark
authors: M
authors: Dürr
authors: Benedikt
authors: B
authors: Westermann
mesh_terms: D008928:Mitochondria / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D024101:Mitochondrial Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000502:physiology* / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins; D029701:Saccharomyces cerevisiae Proteins