An integrated approach to developing chemoenzymatic processes at the industrial scale.
Biocatalysis is becoming a transformational technology for chemical synthesis as a result of recent advances in enzyme discovery, structural biology, protein expression, high-throughput screening, and enzyme evolution technologies. To truly impact chemical synthesis at the industrial scale, biotransformations and chemical research and development must be integrated to develop cost-effective and environmentally friendly solutions for drug manufacture. In this chapter, some recent applications of chemoenzymatic synthesis of pharmaceutically active ingredients or advanced intermediates were selected to illustrate the principle of this integrated approach.
Tao
J
J
BioVerdant, Inc., 7330 Carroll Road, 92121 San Diego, USA. alex.tao@BioVerdant.com
Zhao
L
L
D001407:Bacillus / Q000201:enzymology; D001709:Biotechnology; D001711:Biotransformation; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003362:Cost-Benefit Analysis; D015195:Drug Design; D004798:Enzymes / Q000737:chemistry; D005634:Fructose-Bisphosphate Aldolase / Q000737:chemistry; D017320:HIV Protease Inhibitors / Q000737:chemistry; D007555:Isoxazoles; D008956:Models, Chemical; D008962:Models, Theoretical; D010080:Oxazoles / Q000737:chemistry; D004364:Pharmaceutical Preparations; D010649:Phenylalanine / Q000031:analogs & derivatives; D011759:Pyrrolidines / Q000737:chemistry; D011760:Pyrrolidinones; D013237:Stereoisomerism; D014633:Valine / Q000031:analogs & derivatives
D004798:Enzymes; D017320:HIV Protease Inhibitors; D007555:Isoxazoles; D010080:Oxazoles; D004364:Pharmaceutical Preparations; D011759:Pyrrolidines; D011760:Pyrrolidinones; D010649:Phenylalanine; D005634:Fructose-Bisphosphate Aldolase; D014633:Valine; C118874:rupintrivir