Aldosteronism and hypertension.
A growing body of evidence suggests that hyperaldosteronism contributes significantly to the development and the severity of hypertension as well as to resistance to antihypertensive treatment. In cross-sectional analyses, plasma aldosterone levels have been shown to relate to BP levels, particularly in obese individuals. In these same individuals, BP was not related to plasma renin activity, suggesting an effect of aldosterone on BP independent of renin-angiotensin II. In a recent prospective analysis from the Framingham investigators, baseline serum aldosterone was strongly associated with development of hypertension during a 4-yr follow-up.
Calhoun
David A
DA
Vascular Biology and Hypertension Program, Sleep/Wake Disorders Center, University of Alabama at Birmingham, Birmingham, Alabama, USA. dcalhoun@uab.edu
D000450:Aldosterone / Q000097:blood; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D008403:Mass Screening; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D012720:Severity of Illness Index
D000959:Antihypertensive Agents; D000451:Mineralocorticoid Receptor Antagonists; D000450:Aldosterone