Topical atropine sulfate for the treatment of axillary hyperhidrosis.
BACKGROUND
Axillary hyperhidrosis does not have a low-cost, free of secondary effects, satisfactory treatment. Eccrine hidrocystomas have been successfully treated with topical atropine solution. Hypothesis Axillary hyperhidrosis could respond to the topical application of atropine solution.


METHODS
Ten patients were selected. Eight with mild pure primary axillary hyperhidrosis and two with compensatory sweating after sympathectomy. One milliliter of a water solution of atropine sulfate at 1% was applied twice a day over the affected area and massaged for 30 s. Treatment was maintained for 15 days. The results were rated using a scale from 1 to 10 of satisfaction.


RESULTS
Only 2 of the 10 treated patients responded partially to the topical application of atropine sulfate. No local or systemic secondary effects were observed.


CONCLUSIONS
The results of the study demonstrated that focal hyperhidrosis does not improve after the local application of anticholinergic drugs such as atropine sulfate.
Grimalt
Ramon
R
Department of Dermatology, Hospital Clinic, University of Barcelona, Barcelona, Spain. grimalt@ub.edu
Domínguez Tordera
Patricia
P
Callejas
Marco A
MA
D000005:Abdomen; D000279:Administration, Cutaneous; D001285:Atropine / Q000008:administration & dosage / Q000627:therapeutic use*; D001365:Axilla; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D008297:Male; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D017060:Patient Satisfaction; D017211:Treatment Failure
D018727:Muscarinic Antagonists; D001285:Atropine