title: Is autism partly a consolidation disorder?
abstract: Computational modeling has been useful for understanding processes of encoding and consolidation in cortical structures. In particular, this work suggests a role of neuromodulators in setting dynamics for consolidation processes during different stages of waking and sleep. Because autistic individuals show symptoms of a cognitive nature coupled with a high prevalence of comorbid conditions such as epileptiform discharge during sleep and sleep disorders, it is possible that autism could involve a breakdown in consolidation processes, which are essential to build effective cognitive representations of the environment on the basis of individual experiences. In this article, theories of consolidation during different stages of waking and sleep and the role of different neuromodulators in these consolidation processes are reviewed in conjunction with different features of autism, which may be understood in the context of these theories.
authors: Boston University, USA.
authors: Lisa A
authors: LA
authors: Femia
authors: Michael E
authors: ME
authors: Hasselmo
mesh_terms: D001321:Autistic Disorder / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000503:physiopathology; D003198:Computer Simulation; D004827:Epilepsy / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008568:Memory / Q000502:physiology*; D011582:Psychological Theory; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D014851:Wakefulness / Q000502:physiology*
chemical_list: D012701:Serotonin