CD38 regulates oxytocin secretion and complex social behavior.
The peptide hormone oxytocin plays a critical role in regulating affiliative behaviors including mating, pair-bond formation, maternal/parenting behavior, social recognition, separation distress and other aspects of attachment. Jin and colleagues recently reported intriguing findings that CD38, a transmembrane receptor with ADP-ribosyl cyclase activity, plays a critical role in maternal nurturing behavior and social recognition by regulating oxytocin secretion. This research may have implications for understanding disorders marked by deficits in social cognition and social functioning, including autism, social anxiety disorder, borderline personality disorder and schizophrenia.
Bartz
Jennifer A
JA
Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029-6574, USA. jennifer.bartz@mssm.edu
McInnes
L Alison
LA
D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism*; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D010121:Oxytocin / Q000378:metabolism*; D012919:Social Behavior
D001127:Arginine Vasopressin; D010121:Oxytocin; D051997:ADP-ribosyl Cyclase 1