title: A role for excitatory amino acids in diabetic eye disease.
abstract: Diabetic retinopathy is a leading cause of vision loss. The primary clinical hallmarks are vascular changes that appear to contribute to the loss of sight. In a number of neurodegenerative disorders there is an appreciation that increased levels of excitatory amino acids are excitotoxic. The primary amino acid responsible appears to be the neurotransmitter glutamate. This review examines the nature of glutamatergic signaling at the retina and the growing evidence from clinical and animal model studies that glutamate may be playing similar excitotoxic roles at the diabetic retina.
authors: Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.
authors: Jose E
authors: JE
authors: Pulido
authors: Jose S
authors: JS
authors: Pulido
authors: Jay C
authors: JC
authors: Erie
authors: Jorge
authors: J
authors: Arroyo
authors: Kurt
authors: K
authors: Bertram
authors: Miao-Jen
authors: MJ
authors: Lu
authors: Scott A
authors: SA
authors: Shippy
mesh_terms: D000818:Animals; D003930:Diabetic Retinopathy / Q000378:metabolism*; D018846:Excitatory Amino Acids / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009422:Nervous System Diseases / Q000378:metabolism; D012160:Retina / Q000378:metabolism*; D015398:Signal Transduction; D014822:Vitreous Body / Q000378:metabolism
chemical_list: D018846:Excitatory Amino Acids; D018698:Glutamic Acid
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