Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions.
Delusions are maladaptive beliefs about the world. Based upon experimental evidence that prediction error-a mismatch between expectancy and outcome--drives belief formation, this study examined the possibility that delusions form because of disrupted prediction--error processing. We used fMRI to determine prediction-error-related brain responses in 12 healthy subjects and 12 individuals (7 males) with delusional beliefs. Frontal cortex responses in the patient group were suggestive of disrupted prediction-error processing. Furthermore, across subjects, the extent of disruption was significantly related to an individual's propensity to delusion formation. Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs.
Corlett
P R
PR
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Murray
G K
GK
Honey
G D
GD
Aitken
M R F
MR
Shanks
D R
DR
Robbins
T W
TW
Bullmore
E T
ET
Dickinson
A
A
Fletcher
P C
PC
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology; D001245:Association Learning; D001288:Attention; D001479:Basal Ganglia / Q000187:drug effects / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D003702:Delusions / Q000209:etiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents
J Clin Psychiatry. 2003 Jun;64(6):663-7
12823080
Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8467-72
15159546
Learn Behav. 2005 May;33(2):147-59
16075835
Eur J Pharmacol. 1970 May;10(2):193-205
5446375
J Neurosci. 1997 Apr 15;17(8):2921-7
9092613
Psychol Med. 1995 May;25(3):619-30
7480441
Biol Psychiatry. 2000 Jul 15;48(2):99-109
10903406
Psychol Med. 1996 Jan;26(1):39-49
8643762
Neuroscience. 1991;41(1):1-24
1676137
Acta Psychiatr Scand Suppl. 1999;395:129-37
10225342
Science. 1976 Apr 30;192(4238):481-3
3854
Psychol Rev. 1982 Sep;89(5):529-72
7178332
Brain. 1997 Oct;120 ( Pt 10):1823-43
9365373
Pharmacopsychiatry. 2006 Feb;39 Suppl 1:S68-71
16508900
Psychol Med. 2005 Jul;35(7):1031-41
16045069
Prog Brain Res. 1999;121:327-49
10551035
Q J Exp Psychol B. 2001 Feb;54(1):3-25
11216300
Neuroimage. 2003 Jul;19(3):1233-9
12880848
Cereb Cortex. 2004 Aug;14(8):872-80
15054060
Arch Gen Psychiatry. 1994 Mar;51(3):199-214
8122957
Psychol Med. 2005 Jan;35(1):5-12
15842024
Nature. 2001 Jul 5;412(6842):43-8
11452299
Med Hypotheses. 1976 Sep-Oct;2(5):203-11
9558
Neuroimage. 1998 Jan;7(1):30-40
9500830
Psychol Med. 1998 Mar;28(2):463-73
9572103
Annu Rev Neurosci. 2001;24:167-202
11283309
Neuron. 2004 Dec 2;44(5):877-88
15572117
Br J Psychiatry. 1966 Mar;112(484):225-51
4957283
Philos Trans R Soc Lond B Biol Sci. 1996 Oct 29;351(1346):1515-27
8941963
Ann N Y Acad Sci. 2003 Nov;1003:138-58
14684442
Science. 1974 Sep 27;185(4157):1124-31
17835457
J Psychopharmacol. 2007 May;21(3):238-52
17591652
Psychiatry. 1992 Feb;55(1):79-94
1557472
J Neurosci. 2005 May 18;25(20):5013-23
15901782
Nat Neurosci. 2001 Oct;4(10):1043-8
11559855
Proc Natl Acad Sci U S A. 2005 May 17;102(20):7338-43
15883365
Brain Res Cogn Brain Res. 2004 Nov;21(3):377-87
15511653
Psychol Rev. 1980 Nov;87(6):532-52
7443916
Nat Neurosci. 2002 Mar;5(3):267-71
11865311
Biol Psychiatry. 1999 Mar 15;45(6):660-7
10187995
Am J Psychiatry. 1991 Oct;148(10):1301-8
1654746
Arch Gen Psychiatry. 2002 Jul;59(7):663-4
12090822
Biol Psychiatry. 1999 Jul 1;46(1):40-55
10394473
Neuropsychopharmacology. 1999 Mar;20(3):201-25
10063482
Trends Neurosci. 2004 Nov;27(11):683-90
15474169
Annu Rev Neurosci. 2000;23:473-500
10845072
J Psychiatr Res. 1999 Nov-Dec;33(6):523-33
10628529
Acta Pharmacol Toxicol (Copenh). 1963;20:140-4
14060771
J Neural Transm Gen Sect. 1993;91(2-3):111-34
8099795
Psychiatry Res. 1995 Sep 29;61(3):161-71
8545500
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4354-8
12505
Trends Neurosci. 1997 Jan;20(1):38-43
9004418
Br J Med Psychol. 1961;34:103-16
13773940
Am J Psychiatry. 2001 Sep;158(9):1367-77
11532718
Eur J Pharmacol. 1970;11(3):303-14
5477307
Arch Gen Psychiatry. 1995 Dec;52(12):998-1007
7492260
J Individ Psychol. 1974 May;30(1):98-113
4857199
Hum Brain Mapp. 1999;8(2-3):102-8
10524600
Schizophr Bull. 1990;16(3):391-402
2287930
Br J Psychiatry Suppl. 1999;(37):2-6
10211132
Am J Psychiatry. 2003 Jan;160(1):13-23
12505794
Arch Gen Psychiatry. 2006 Jun;63(6):611-21
16754834