Fatty acid profile in milk from goats, Capra aegagrus hircus, exposed to perchlorate and its relationship with perchlorate residues in human milk.
Polyunsaturated fatty acids (PUFA) in milk are vital for normal growth and development of infant mammals. Changes in fatty acid composition were observed in milk fat from goats dosed with perchlorate (0.1 and 1 mg/kg body weight/day) for 31 days, but the effect was not persistent. Adaptation may be induced in these goats to compensate for the perchlorate effect. In an analysis of fatty acid composition in human milk samples, a weak negative correlation was observed between perchlorate concentrations and total PUFA in 38 human milk samples.
Cheng
Qiuqiong
Q
Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409-1163, USA.
Smith
Ernest E
EE
Kirk
Andrea B
AB
Liu
Fujun
F
Boylan
Lee Mallory
LM
McCarty
Michael E
ME
Hart
Sybil
S
Dong
Linxia
L
Cobb
George P
GP
Jackson
W Andrew
WA
Anderson
Todd A
TA
D000818:Animals; D015992:Body Mass Index; D001942:Breast Feeding; D004305:Dose-Response Relationship, Drug; D005231:Fatty Acids, Unsaturated / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006041:Goats / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D010472:Perchlorates / Q000378:metabolism / Q000633:toxicity*; D011247:Pregnancy; D013997:Time Factors
D005231:Fatty Acids, Unsaturated; D010472:Perchlorates; C494474:perchlorate