title: Human gamma delta T cells: candidates for the development of immunotherapeutic strategies.
abstract: A numerically small subset of human T lymphocytes expresses a gamma delta T cell receptor (TCR). These gamma delta T cells share certain effector functions with alpha beta T cells as well as with NK cells and NKT cells. The major peripheral blood gamma delta T cell subset in healthy adults expresses a Vgamma9Vdelta2 TCR, which recognizes small phosphorylated metabolites referred to as phosphoantigens. Vdelta1 gamma delta T cells mainly occur in the intestine. They recognize the stress-induced MICA/B and CD1c. Furthermore, gamma delta T cells express a variety of NK cell and pattern-recognition receptors which are responsible for the "fine-tuning" of effector functions. In recent years, gamma delta T cells start to emerge as a rewarding target for immunotherapeutic strategies against viral infections and cancer. A better understanding of factors that modulate gamma gamma delta T cell function will further eluminate the potential of these cells.
authors: Institute of Immunology, University Hospital Schleswig-Holstein Campus Kiel, Michaelisstr. 5, 24105 Kiel, Germany. beetz@immunologie.uni-kiel.de
authors: Susann
authors: S
authors: Beetz
authors: Lothar
authors: L
authors: Marischen
authors: Dieter
authors: D
authors: Kabelitz
authors: Daniela
authors: D
authors: Wesch
mesh_terms: D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007694:Killer Cells, Natural / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta; D051193:Toll-Like Receptors
references: Bone Marrow Transplant. 2001 May;27(10):1087-93
references: 11438826
references: Eur J Immunol. 1996 Mar;26(3):557-62
references: 8605921
references: Mol Med. 2001 Jan;7(1):11-9
references: 11474123
references: J Bone Miner Res. 2004 Feb;19(2):278-88
references: 14969398
references: Clin Exp Immunol. 2004 Jun;136(3):472-82
references: 15147349
references: Expert Rev Anticancer Ther. 2005 Dec;5(6):973-86
references: 16336088
references: Cancer Immunol Immunother. 2001 May;50(3):115-24
references: 11419178
references: Microbes Infect. 2005 Mar;7(3):518-28
references: 15777667
references: J Invest Dermatol. 2006 Jan;126(1):25-31
references: 16417214
references: J Immunol. 2003 Sep 15;171(6):3154-62
references: 12960343
references: Eur J Immunol. 1997 Nov;27(11):2812-21
references: 9394804
references: J Immunol. 2004 Jan 1;172(1):138-43
references: 14688319
references: Infect Immun. 2006 Aug;74(8):4505-11
references: 16861636
references: Eur J Med Res. 2001 Apr 20;6(4):169-74
references: 11309229
references: Cell Immunol. 1999 May 25;194(1):12-20
references: 10357876
references: Blood. 2006 Jan 15;107(2):651-4
references: 16179378
references: Eur J Immunol. 1993 Apr;23(4):804-8
references: 8384559
references: J Biol Chem. 2001 May 25;276(21):18337-44
references: 11279081
references: J Exp Med. 2003 Jan 20;197(2):163-8
references: 12538656
references: Int Immunol. 1992 Mar;4(3):361-6
references: 1533150
references: J Immunol. 2005 Oct 15;175(8):5481-8
references: 16210656
references: Immunity. 2005 Jan;22(1):71-80
references: 15664160
references: Nature. 1998 Feb 19;391(6669):795-9
references: 9486650
references: FEBS Lett. 2003 Jun 5;544(1-3):4-10
references: 12782281
references: J Natl Cancer Inst. 1996 Apr 3;88(7):436-41
references: 8618235
references: Immunol Lett. 1996 Mar;49(3):191-6
references: 8739316
references: Br J Haematol. 1998 Mar;100(4):728-34
references: 9531341
references: Int J Cancer. 2004 Dec 10;112(5):727-32
references: 15386388
references: Science. 2005 Apr 8;308(5719):227-31
references: 15821084
references: J Exp Med. 1994 Jul 1;180(1):183-90
references: 8006582
references: Oncol Rep. 2005 Mar;13(3):509-15
references: 15706426
references: Science. 1998 Mar 13;279(5357):1737-40
references: 9497295
references: J Leukoc Biol. 2004 Sep;76(3):545-52
references: 15197233
references: Eur J Immunol. 2005 Jun;35(6):1896-905
references: 15864777
references: J Immunol. 2005 Aug 1;175(3):1551-7
references: 16034093
references: Eur J Immunol. 1998 Nov;28(11):3399-410
references: 9842883
references: Clin Exp Immunol. 1989 Feb;75(2):206-10
references: 2522839
references: J Clin Invest. 1999 May 15;103(10):1437-49
references: 10330426
references: J Exp Med. 2003 Aug 4;198(3):433-42
references: 12900519
references: J Leukoc Biol. 2005 Jan;77(1):67-70
references: 15498816
references: Immunol Lett. 1993 Oct;38(2):121-6
references: 8294139
references: Cancer Res. 1992 Oct 15;52(20):5610-6
references: 1394184
references: Cell Mol Life Sci. 2006 Sep;63(18):2089-94
references: 17003966
references: J Acquir Immune Defic Syndr. 2003 Aug 1;33(4):420-5
references: 12869830
references: Curr Opin Immunol. 2006 Oct;18(5):539-46
references: 16870417
references: Blood. 2000 Jul 15;96(2):384-92
references: 10887096
references: J Leukoc Biol. 2004 Apr;75(4):657-63
references: 14704367
references: Ann Oncol. 2005 Apr;16(4):590-6
references: 15699022
references: Eur J Immunol. 2005 Sep;35(9):2670-8
references: 16114098
references: J Immunol. 1997 Dec 15;159(12):6009-17
references: 9550399
references: J Virol. 2003 Feb;77(3):1848-55
references: 12525619
references: Cancer Immunol Immunother. 2006 Sep;55(9):1072-80
references: 16328383
references: Immunology. 2004 Jul;112(3):369-77
references: 15196204
references: Curr Top Microbiol Immunol. 2006;298:121-38
references: 16329186
references: Int Immunol. 2006 Jan;18(1):11-8
references: 16361319
references: J Immunol. 1997 Aug 1;159(3):1328-35
references: 9233629
references: Immunology. 2000 Nov;101(3):325-32
references: 11106935
references: J Exp Med. 1990 May 1;171(5):1597-612
references: 2185330
references: J Exp Med. 2005 May 16;201(10):1567-78
references: 15897274
references: J Immunol. 2005 Aug 15;175(4):2144-51
references: 16081780
references: J Immunol. 2001 Dec 15;167(12):6773-9
references: 11739492
references: FEBS Lett. 2001 Dec 7;509(2):317-22
references: 11741609
references: Cancer Immunol Immunother. 1997 Mar;44(1):27-34
references: 9111581
references: J Immunol. 1995 Apr 15;154(8):3932-40
references: 7706731
references: J Immunol. 2006 Feb 1;176(3):1386-93
references: 16424165
references: Clin Exp Immunol. 2002 Mar;127(3):527-32
references: 11966771
references: Cancer Res. 2004 Jan 1;64(1):378-85
references: 14729648
references: N Engl J Med. 1999 Mar 4;340(9):737-8
references: 10068336
references: Immunology. 2006 Jan;117(1):1-10
references: 16423035
references: J Immunol. 2001 Jun 1;166(11):6784-94
references: 11359837
references: J Immunol. 2002 May 15;168(10):4920-9
references: 11994442
references: J Allergy Clin Immunol. 2006 May;117(5):979-87; quiz 988
references: 16675322
references: J Infect Dis. 1992 May;165(5):917-9
references: 1533237
references: J Immunol. 1995 Feb 1;154(3):998-1006
references: 7529807
references: J Immunol. 2004 Dec 1;173(11):6767-76
references: 15557170
references: Immunol Cell Biol. 2004 Jun;82(3):295-306
references: 15186261
references: J Immunol. 2005 Aug 1;175(3):1636-42
references: 16034103
references: Blood. 2004 Dec 15;104(13):4157-64
references: 15315972
references: Immunol Rev. 1991 Apr;120:137-83
references: 1650758
references: J Immunol. 1996 Dec 1;157(11):4741-5
references: 8943374
references: Science. 1999 Jul 30;285(5428):727-9
references: 10426993
references: Int Immunol. 1998 Aug;10(8):1067-75
references: 9723692
references: Microbes Infect. 2005 Mar;7(3):503-9
references: 15823511
references: J Immunol. 1989 Oct 15;143(8):2480-8
references: 2477444
references: Immunity. 2001 Jul;15(1):83-93
references: 11485740
references: J Immunol. 2002 Jan 15;168(2):554-61
references: 11777946
references: Immunity. 1995 Oct;3(4):495-507
references: 7584140
references: J Immunol. 2003 Sep 1;171(5):2524-31
references: 12928402
references: J Immunol. 2005 Oct 15;175(8):5471-80
references: 16210655
references: J Exp Med. 2003 Aug 4;198(3):391-7
references: 12900516
references: J Exp Med. 1994 Jan 1;179(1):323-8
references: 8270877
references: J Exp Med. 1990 Mar 1;171(3):667-79
references: 2137854
references: Cell Immunol. 2005 Jul-Aug;236(1-2):140-5
references: 16188245
references: Biochem Biophys Res Commun. 2006 Jan 6;339(1):232-40
references: 16297874
references: Blood. 2003 Jul 1;102(1):200-6
references: 12623838
references: Science. 2001 Oct 19;294(5542):605-9
references: 11567106
references: J Immunol. 2006 Feb 1;176(3):1348-54
references: 16424161
references: J Immunol. 2005 Nov 1;175(9):5656-65
references: 16237055
references: Nat Rev Immunol. 2006 Apr;6(4):295-307
references: 16557261
references: Blood. 2001 Sep 1;98(5):1616-8
references: 11520816
references: J Immunol. 1994 May 15;152(10):4984-92
references: 7909828
references: Eur J Immunol. 1990 May;20(5):1175-9
references: 2141570
references: J Immunol. 2006 Oct 15;177(8):5290-5
references: 17015714
references: Semin Immunol. 2006 Jun;18(3):151-8
references: 16730454
references: Blood. 2004 Sep 15;104(6):1801-7
references: 15178578
references: J Exp Med. 2006 Feb 20;203(2):289-95
references: 16461340
references: Mol Immunol. 2006 May;43(12):2002-11
references: 16423401
references: J Immunol. 2005 Feb 1;174(3):1338-47
references: 15661891
references: Immunol Lett. 2005 Aug 15;100(1):14-20
references: 16115692
references: Crit Rev Immunol. 2003;23(5-6):473-88
references: 15030308
references: J Immunol. 2003 Nov 15;171(10):4979-83
references: 14607892
references: J Infect Dis. 1999 Sep;180(3):858-61
references: 10438380
references: J Exp Med. 2004 Mar 15;199(6):879-84
references: 15007091
references: Clin Exp Immunol. 1991 Feb;83(2):187-91
references: 1825186
references: Nature. 2001 Jun 14;411(6839):820-4
references: 11459064
references: J Clin Oncol. 2003 Aug 15;21(16):3127-32
references: 12915604
references: Adv Immunol. 1995;59:1-98
references: 7484459
references: J Immunol. 2002 Aug 1;169(3):1236-40
references: 12133944
references: J Exp Med. 2002 Apr 1;195(7):855-67
references: 11927630
references: Int J Cancer. 2001 May 1;92(3):421-5
references: 11291081
references: Trends Immunol. 2001 Jul;22(7):378-85
references: 11429322
references: J Invest Dermatol. 2006 Feb;126(2):393-8
references: 16374454
references: J Immunol. 2005 Jan 1;174(1):252-60
references: 15611247
references: J Hepatol. 2002 Oct;37(4):514-22
references: 12217606
references: Immunity. 1999 Jul;11(1):57-65
references: 10435579
references: J Exp Med. 1996 Apr 1;183(4):1681-96
references: 8666926
references: J Exp Med. 1997 Nov 17;186(10):1769-74
references: 9362537
references: Immunogenetics. 1995;42(6):455-500
references: 8550092
references: J Immunol. 2004 Feb 1;172(3):1637-45
references: 14734745
references: Annu Rev Immunol. 2000;18:975-1026
references: 10837080
references: J Immunol. 2006 Apr 1;176(7):4331-6
references: 16547270
references: Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6879-84
references: 10359807
references: Eur J Immunol. 1994 Dec;24(12):3044-9
references: 7805732
references: J Biol Chem. 1999 Nov 5;274(45):32079-84
references: 10542241
references: J Clin Invest. 1995 Jul;96(1):610-9
references: 7615835
references: Cancer Immunol Immunother. 2007 Apr;56(4):469-76
references: 16850345
references: J Immunol. 1998 Jun 1;160(11):5239-45
references: 9605119
references: Clin Exp Immunol. 2006 Jun;144(3):528-33
references: 16734623
references: Immunology. 1994 Feb;81(2):234-9
references: 8157272
references: Cancer Res. 2004 Dec 15;64(24):9172-9
references: 15604289
references: Blood. 2003 Sep 15;102(6):2310-1
references: 12959943
references: J Virol. 2003 Oct;77(19):10456-67
references: 12970431
references: Immunobiology. 1992 Apr;184(4-5):392-401
references: 1350566
references: J Exp Med. 2000 Mar 20;191(6):937-48
references: 10727456
references: J Immunol. 2004 Sep 15;173(6):3660-7
references: 15356111