Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women.
OBJECTIVE
The objective was to examine the association of 5 common single nucleotide polymorphisms (SNPs) at the adiponectin locus with risk of coronary heart disease (CHD) in men and women.


METHODS
We genotyped five common SNPs in the adiponectin gene (rs266729, -11365C>G; rs822395, -4034A>C; rs822396, -3964A>G; rs2241766, +45T>G; and rs1501299, +276G>T) in men (Health Professionals Follow-up Study) and women (Nurses' Health Study) in a nested case control setting. Among participants free of cardiovascular disease at baseline, 266 men and 249 women developed non-fatal myocardial infarction or fatal CHD during 6 and 8 years of follow-up, respectively. In addition, 564 men had coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty. Using risk set sampling, controls were selected 2:1 matched on age, smoking, and date of blood draw.


RESULTS
The -4034CC genotype was related to an increased risk of non-fatal myocardial infarction or fatal CHD compared with the AA genotype [relative risk (RR), men, 1.69; 95% confidence interval (CI), 0.99 to 2.89; women, 2.04; 95% CI, 1.20 to 3.49); however, this genotype was not related to risk of coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty or to plasma adiponectin levels. Other SNPs or haplotypes defined by the 5 SNPs were not consistently related to risk of CHD in men and women or to plasma adiponectin levels.


CONCLUSIONS
Our study does not support the hypothesis that these 5 common SNPs in the adiponectin gene play an important role in the development of CHD among men and women, although we cannot exclude an association between the -4034CC genotype and risk of CHD.
Pischon
Tobias
T
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. pischon@mail.dife.de
Pai
Jennifer K
JK
Manson
JoAnn E
JE
Hu
Frank B
FB
Rexrode
Kathryn M
KM
Hunter
David
D
Rimm
Eric B
EB
D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012737:Sex Factors
D052242:Adiponectin; D047495:PPAR gamma; D004247:DNA