title: Vascular endothelial growth factor receptor-1 levels in hepatocellular carcinoma and correlations with clinicopathological features.
abstract: OBJECTIVE
  To determine the serum vascular endothelial growth factor receptor-1 (VEGFR-1) levels in hepatocellular carcinoma patients and its correlations with the clinical and laboratory parameters.
  
  
  METHODS
  Serum VEGFR-1 levels were measured in 18 biopsy-proven treatment-naive hepatocellular carcinoma patients (female/male: 5/13; mean age: 59.22 +/- 13.15 years) and in age- and sex-matched healthy controls. Possible associations were also evaluated between serum VEGFR-1 levels and etiology and severity of chronic liver disease, serum alpha-fetoprotein levels, presence of ascites and portal vein thrombosis, and tumor number, size and stage.
  
  
  RESULTS
  Serum VEGFR-1 levels were undetectable in all healthy subjects, while all of the patients with hepatocellular carcinoma had increased VEGFR-1 (p < 0.001). Serum VEGFR-1 levels did not correlate with the clinical and laboratory parameters and tumor characteristics in hepatocellular carcinoma.
  
  
  CONCLUSIONS
  VEGFR-1 is involved in the regulation of carcinogenesis in hepatocellular carcinoma.
authors: Department of Gastroenterology, Türkiye Yülksek Ihtisas Hospital, Ankara.
authors: Omer Faruk
authors: OF
authors: Yolcu
authors: Seyfettin
authors: S
authors: Köklü
authors: Osman
authors: O
authors: Yüksel
authors: Sahin
authors: S
authors: Coban
authors: Selime
authors: S
authors: Ayaz
authors: M
authors: M
authors: Akif Oztürk
authors: Mustafa
authors: M
authors: Benekli
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D040281:Vascular Endothelial Growth Factor Receptor-1