Ruptured thoracoabdominal aortic aneurysm in a renal transplant patient with Alport's syndrome.
Alport's syndrome is a rare genetic disorder of type IV basement membrane collagen synthesis that typically presents with nephropathy, deafness, and ocular abnormalities. To the best of our knowledge, this is the first report in the world's literature of ruptured thoracoabdominal aortic aneurysm in a young patient with Alport's syndrome and a renal transplant. Hypotheses on an association between collagen disease in Alport's syndrome and aortic aneurysms are discussed.
Lyons
O T A
OT
Department of Vascular and Endovascular Surgery, Guy's and St. Thomas' NHS Foundation Hospital, London, UK.
St John
E R C
ER
Morales
J P
JP
Chan
Y C
YC
Taylor
P R
PR
D000328:Adult; D000714:Anastomosis, Surgical; D017545:Aortic Aneurysm, Thoracic / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D001019:Aortic Rupture / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation; D020878:Device Removal; D006083:Graft Occlusion, Vascular / Q000601:surgery; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D009394:Nephritis, Hereditary / Q000150:complications / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome