In vitro biological-to-immunological ratio of serum gonadotropins throughout male puberty in children with insulin-dependent diabetes mellitus.
Information on the impact of prolonged deficient glycemic control in the quality of the gonadotropin signal delivered by the pituitary gland during puberty in children with insulin-dependent diabetes mellitus (IDDM) is scarce. In the present study, we examined the impact of deficient glycemic control on bioactive LH and FSH concentrations and their corresponding biological-to-immunological (B:I) ratio in boys with poorly controlled, but systemically uncomplicated IDDM. Dual control groups comprising patients with well-controlled IDDM and healthy boys of comparable age and body mass index were included for appropriate comparisons within and between each pubertal stage. Patients with poorly controlled and well-controlled IDDM exhibited serum bioactive FSH levels and B:I FSH ratio similar to those showed by the healthy control group. In contrast, in early and mid-pubertal boys with poorly controlled IDDM bioactive LH levels were normal, but its B:I LH relationship was significantly (P < 0.05) decreased. This attenuation in the quality of the LH signal did not affect total serum T concentrations, and apparently, progression of puberty. Long-standing uncontrolled diabetes and the consequent metabolic disturbances and/or complications may aggravate the reproductive axis dysfunction and eventually provoke pubertal arrest.
Nishimura
Elisa
E
Department of Endocrinology, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, DF, 06700, México.
Söderlund
Daniela
D
Castro-Fernández
Cecilia
C
Zariñán
Teresa
T
Méndez
Juan Pablo
JP
Ulloa-Aguirre
Alfredo
A
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011627:Puberty / Q000097:blood*; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Pediatr Res. 1995 Oct;38(4):607-11
8559617
Endocrine. 1999 Dec;11(3):205-15
10786817
J Androl. 1992 Jan-Feb;13(1):11-22
1551802
J Clin Endocrinol Metab. 1987 Jul;65(1):127-35
3584393
Hum Reprod. 2001 Apr;16(4):599-604
11278201
Hum Reprod. 2001 Aug;16(8):1611-8
11473951
Hum Reprod. 2000 Nov;15(11):2285-91
11056120
J Clin Endocrinol Metab. 2000 Dec;85(12):4603-10
11134115
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11127-31
8248218
J Endocrinol. 1991 Oct;131(1):49-55
1744558
Endocrine. 2004 Mar-Apr;23(2-3):189-98
15146100
J Clin Endocrinol Metab. 1994 Sep;79(3):814-9
8077366
Talanta. 1984 Oct;31(10 Pt 2):909-16
18963767
Recent Prog Horm Res. 1984;40:43-78
6207567
Endocrinology. 1994 Nov;135(5):2204-13
7956943
Anal Biochem. 1984 Mar;137(2):335-43
6375455
J Clin Endocrinol Metab. 1987 Jun;64(6):1275-82
3553222
Eur J Pediatr. 1998 Dec;157(12):972-7
9877034
Endocr Rev. 1995 Dec;16(6):765-87
8747835
Pediatr Res. 1970 Jan;4(1):25-35
5416996
J Clin Endocrinol Metab. 1982 Oct;55(4):682-8
6809781
Mol Cell Endocrinol. 1990 Oct 1;73(1):15-26
1705525
Hum Reprod. 2001 Jun;16(6):1058-64
11387269
J Clin Endocrinol Metab. 1993 Apr;76(4):885-9
8473400
Exp Clin Endocrinol Diabetes. 2000;108(1):14-20
10768827
Clin Endocrinol (Oxf). 1994 Jun;40(6):783-9
8033370
J Clin Endocrinol Metab. 1993 Feb;76(2):432-8
8432787
J Clin Invest. 1982 Jun;69(6):1337-47
7085877
Endocrinology. 1980 Jun;106(6):1941-8
7371598
Endocr Res. 2001 Feb-May;27(1-2):109-17
11428703
Eur J Endocrinol. 1995 Jul;133(1):48-56
7627337
Horm Res. 1991;36(3-4):93-6
1818015
Clin Endocrinol (Oxf). 1996 Feb;44(2):181-9
8849573
J Clin Endocrinol Metab. 1995 May;80(5):1647-56
7745013
Fertil Steril. 1981 Jun;35(6):653-6
7250391
J Clin Endocrinol Metab. 1996 May;81(5):1798-805
8626838
Biol Reprod. 2000 May;62(5):1256-61
10775174
Pediatr Res. 1996 Jan;39(1):180-4
8825407
Arch Dis Child. 1970 Feb;45(239):13-23
5440182
J Clin Endocrinol Metab. 1997 Sep;82(9):3103-6
9284752
Diabetes. 2003 Feb;52(2):492-8
12540626
Neuroendocrinology. 2002 Dec;76(6):357-65
12566943
Diabetes Care. 1997 May;20(5):721-4
9135933
Hum Reprod. 2001 May;16(5):825-30
11331624
J R Coll Physicians Lond. 2000 Mar-Apr;34(2):141-6
10816868
Endocrinology. 1992 Oct;131(4):1999-2009
1396343
Mol Hum Reprod. 1998 Jul;4(7):631-9
9701785
Arch Med Res. 2001 Nov-Dec;32(6):520-32
11750727
Diabetes Care. 1998 May;21(5):831-5
9589250
Annu Rev Physiol. 1982;44:595-613
6803663
Scand J Clin Lab Invest. 1991 Jun;51(4):385-93
1947723
Biol Reprod. 2000 May;62(5):1248-55
10775173
Mol Cell Endocrinol. 1991 Jun;78(1-2):137-50
1718793
J Mol Endocrinol. 1999 Oct;23(2):153-65
10514553
Eur J Clin Chem Clin Biochem. 1996 Sep;34(9):749-53
8891528
Annu Rev Biochem. 1981;50:465-95
6267989
Hum Reprod Update. 2004 Jan-Feb;10(1):67-77
15005465
J Clin Invest. 1987 Sep;80(3):631-8
3305575
Endocrine. 2004 Oct;25(1):49-54
15545706
J Clin Endocrinol Metab. 2002 Dec;87(12):5507-15
12466346
Clin Endocrinol (Oxf). 1995 Jan;42(1):59-64
7889633
Horm Metab Res. 1989 Jan;21(1):42-6
2647608
J Clin Endocrinol Metab. 1988 Sep;67(3):465-73
3137241
Neuroendocrinology. 1996 Jun;63(6):514-21
8793893
Andrologia. 1987 Jul-Aug;19(4):464-73
3116885
J Clin Endocrinol Metab. 1992 Dec;75(6):1442-5
1464645
Arch Med Res. 1995;26 Spec No:S219-30
8845653
Biol Reprod. 1991 Jun;44(6):1016-24
1873379
Pediatr Res. 1993 Dec;34(6):829-33
8108202
Endocrine. 1999 Apr;10(2):113-21
10451219
Andrologia. 1982 Jan-Feb;14(1):62-8
6802026