title: Low-fluoride dentifrices with reduced pH: fluoride concentration in whole saliva and bioavailability.
abstract: This double-blind study assessed the fluoride (F) concentration in whole saliva and F bioavailability after the use of low-F dentifrices with reduced pH. Whole saliva was collected from 10 volunteers after brushing with: experimental dentifrices (pH 5.5) 275, 550 and 1,100 ppm F; commercial 500 ppm F, pH 6.9 and a 'gold standard' 1,100 ppm F, pH 6.5. To analyze F bioavailability, 9 volunteers ingested weights of four dentifrices equivalent to 2 mg F: 1,500 ppm F/MFP/CaCO3, pH 9.5; 1,100 ppm F/NaF/silica, pH 5.5; 1,100 ppm F/NaF/silica, pH 7.0 and 1,100 ppm F/NaF/silica, pH 6.5 ('gold standard'). Ductal saliva and urine were collected. F was analyzed by electrode. Data were tested using ANOVA and Tukey's post hoc test (p < 0.05). The 550 ppm F/pH 5.5 dentifrice was similar to the 'gold standard' in its effect on whole saliva F concentration. The area under the curve of ductal saliva F concentration x time and urinary F excretion rates did not differ among the dentifrices. The results show that acidic low-F dentifrices are effective in increasing salivary F concentration and pH reduction does not seem to affect their F bioavailability.
authors: Department of Public Health, Bauru Dental School, University of São Paulo, São Paulo, Brazil.
authors: K P K
authors: KP
authors: Olympio
authors: P A P
authors: PA
authors: Bardal
authors: V E da S
authors: VE
authors: Cardoso
authors: R C
authors: RC
authors: Oliveira
authors: J R de M
authors: JR
authors: Bastos
authors: M A R
authors: MA
authors: Buzalaf
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D019540:Area Under Curve; D001682:Biological Availability; D002327:Cariostatic Agents / Q000032:analysis / Q000493:pharmacokinetics*; D003802:Dentifrices / Q000737:chemistry* / Q000627:therapeutic use; D005459:Fluorides / Q000032:analysis / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D005459:Fluorides