title: Hair follicle: a reliable source of recipient origin after allogeneic hematopoietic stem cell transplantation.
abstract: Blood, buccal swab and hair follicles are among the most commonly used sources for forensic science, parentage testing and personal identification. A total of 29 patients who have had a sustained engraftment from 15 months to 21.5 years after allogeneic hematopoietic stem cell transplantation (HSCT) without rejection, relapse or chronic GVHD involving oral mucosa were enrolled for a chimerism study. PCR-amplified short tandem repeat analyses were conducted per patient every 3 months for at least three consecutive times. The results for blood were all donor type except one who had a mixed chimerism, 14.5 years after receiving a transplant for lymphoma. As for buccal swab, mixed chimerism ranging from 10 to 96% donor origin was noted for 28 recipients except the one who had mixed chimerism of blood and retained total recipient type. In contrast, hair follicles were 100% recipient type for the entire group. It is concluded that the hair follicle is devoid of adult stem cell plasticity and may serve as a reliable source of recipient's origin when pre-transplant DNA fingerprinting or reference DNA is not available for people who have successfully received allogeneic HSCT while in need of a personal identification.
authors: Section of Hemato-Oncology, Department of Medicine, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors: Y C
authors: YC
authors: Hong
authors: H M
authors: HM
authors: Liu
authors: P S
authors: PS
authors: Chen
authors: Y J
authors: YJ
authors: Chen
authors: J Y
authors: JY
authors: Lyou
authors: H Y
authors: HY
authors: Hu
authors: M F
authors: MF
authors: Yi
authors: J S
authors: JS
authors: Lin
authors: C-H
authors: CH
authors: Tzeng
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D044707:Forensic Sciences; D006085:Graft Survival; D018859:Hair Follicle; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D010334:Paternity; D016133:Polymerase Chain Reaction / Q000379:methods; D018183:Transplantation Chimera