title: In vivo bactericidal activities of Japanese rice-fluid against H. pylori in a Mongolian gerbil model.
abstract: OBJECTIVE
  The antibiotic effect of rice-fluid on Helicobacter pylori infection was investigated using a Mongolian gerbil model.
  
  
  METHODS
  Gerbils were divided into four groups: H. pylori -infected, rice-fluid-treated animals (group A); H. pylori -infected, untreated animals (group B); uninfected, rice-fluid-treated animals (group C); and uninfected, untreated animals (group D). Group A and B animals were killed 14 weeks after H. pylori infection and group C and D animals were killed at the same age. The stomachs were examined for histology, 5'-bromo-2'-deoxyuridine (BrdU) labeling, and the bacterial burden. Serum anti-H. pylori antibody titers were also tested.
  
  
  RESULTS
  The positive incidence of H. pylori -culture was 25 and 84 % in groups A and B, respectively (p<0.01). Both the degree of inflammation and the BrdU labeling index in group A were significantly lower than those in group B.
  
  
  CONCLUSIONS
  Rice-fluid showed an antibiotic effect on H. pylori and an anti-inflammatory effect on the H. pylori -associated gastritis.
authors: Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan. ishizone@hsp.md.shinshu-u.ac.jp
authors: Satoshi
authors: S
authors: Ishizone
authors: Fukuto
authors: F
authors: Maruta
authors: Kazufumi
authors: K
authors: Suzuki
authors: Shinichi
authors: S
authors: Miyagawa
authors: Masahiko
authors: M
authors: Takeuchi
authors: Kiyomi
authors: K
authors: Kanaya
authors: Kozue
authors: K
authors: Oana
authors: Masayoshi
authors: M
authors: Hayama
authors: Yoshiyuki
authors: Y
authors: Kawakami
authors: Hiroyoshi
authors: H
authors: Ota
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D004195:Disease Models, Animal; D005756:Gastritis / Q000382:microbiology / Q000517:prevention & control*; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000473:pathology / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000187:drug effects*; D012275:Oryza / Q000737:chemistry*; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D028321:Plant Preparations
references: Microbiol Immunol. 2004;48(4):251-61
references: 15107535
references: Dig Dis Sci. 2005 Aug;50(8):1517-22
references: 16110845
references: Helicobacter. 2001 Sep;6(3):254-61
references: 11683930
references: J Clin Microbiol. 2001 Apr;39(4):1283-8
references: 11283042
references: Gastroenterology. 1998 Sep;115(3):642-8
references: 9721161
references: Pediatrics. 1999 Aug;104(2):e22
references: 10429140
references: Scand J Gastroenterol Suppl. 1996;215:82-9
references: 8722389
references: Int J Med Sci. 2006 Jul 12;3(3):112-6
references: 16906220
references: Am J Surg Pathol. 1996 Oct;20(10):1161-81
references: 8827022
references: Eur J Gastroenterol Hepatol. 2005 Sep;17(9):973-81
references: 16093876
references: Gut. 1997 Dec;41(6):735-9
references: 9462204
references: J Gastroenterol Hepatol. 1991 Mar-Apr;6(2):125-30
references: 1912417
references: Aliment Pharmacol Ther. 2005 May 15;21(10):1263-72
references: 15882248
references: Scand J Gastroenterol. 2001 Mar;36(3):283-90
references: 11305516
references: J Gastroenterol. 2005 May;40(5):459-66
references: 15942710
references: Helicobacter. 1996 Mar;1(1):57-61
references: 9398914
references: J Gastroenterol. 2005 Jan;40(1):104-5
references: 15692797
references: Cancer Res. 1998 May 15;58(10):2067-9
references: 9605743
references: Lancet. 1993 Sep 4;342(8871):575-7
references: 8102719
references: Cancer Res. 2000 Mar 15;60(6):1512-4
references: 10749114
references: J Gastroenterol. 1998;33 Suppl 10:53-6
references: 9840019
references: Clin Microbiol Rev. 1999 Oct;12(4):564-82
references: 10515903
references: Cancer Sci. 2003 Apr;94(4):372-7
references: 12824907
references: J Gastroenterol Hepatol. 1996 Mar;11(3):290-2
references: 8742929
references: Med J Aust. 1985 Apr 15;142(8):436-9
references: 3982345