Three new taxanes with the 10-alkoxy group from the heartwood of Taxus cuspidata.
Three novel taxanes with the 10-alkoxy group were isolated from heartwood of Taxus cuspidata. The structures were identified as 2alpha,14beta-diacetoxy-10beta-ethoxytaxa-11,4(20)-dien-5alpha-ol (1), 2alpha,14beta-diacetoxy-10beta-methoxytaxa-11,4(20)-dien-5alpha-ol (2), and 2alpha-acetoxy-10beta-ethoxytaxa-11,4(20)-diene-5alpha,14beta-diol (3) on the basis of spectroscopic analysis. These are the first taxanes with an alkoxy moiety on the skeleton.
Dong
Mei
M
College of Basic Medicinal Sciences, Hebei Medical University, Shijiazhuang, PR China.
Zhang
Man-Li
ML
Wang
Yu-Fang
YF
Zhang
Xi-Ping
XP
Li
Cun-Fang
CF
Shi
Qing-Wen
QW
Cong
Bin
B
Kiyota
Hiromasa
H
D000438:Alcohols; D015394:Molecular Structure; D013057:Spectrum Analysis; D043823:Taxoids / Q000737:chemistry* / Q000302:isolation & purification; D020946:Taxus / Q000737:chemistry*
D000438:Alcohols; D043823:Taxoids; C059688:alkoxyl radical