title: Activities of clindamycin, synercid, telithromycin, linezolid, and mupirocin against Gram-positive coccal strains resistant to erythromycin in Korea.
abstract: The antibacterial activities of clindamycin, synercid, telithromycin, linezolid and mupirocin were evaluated against erythromycin-resistant Gram-positive coccal clinical isolates collected in Korean hospitals. In Staphylococcus aureus, synercid, linezolid and mupirocin were the most active agents. Against coagulase-negative staphylococci (CNS), synercid, linezolid and mupirocin were also active. Telithromycin and synercid resistance was common against enterococci, only linezolid and mupirocin were active. The reason of low activity of telithromycin against staphylococci and enterococci is because most of the isolates were constitutively resistant to erythromycin. Synercid, telithromycin, linezolid and mupirocin were active against streptococci.
authors: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151742, Korea.
authors: Ae-Ran
authors: AR
authors: Kwon
authors: Eun-Jeong
authors: EJ
authors: Yoon
authors: Jong-Min
authors: JM
authors: Yoon
authors: Hyunjee
authors: H
authors: Kim
authors: Mi-Ja
authors: MJ
authors: Shim
authors: Eung-Chil
authors: EC
authors: Choi
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D004917:Erythromycin / Q000494:pharmacology*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D048628:Ketolides / Q000494:pharmacology; D007723:Korea; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D016712:Mupirocin / Q000494:pharmacology; D023303:Oxazolidinones / Q000494:pharmacology; D014769:Virginiamycin / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D048628:Ketolides; D023303:Oxazolidinones; D014769:Virginiamycin; C062940:quinupristin-dalfopristin; D002981:Clindamycin; D004917:Erythromycin; D016712:Mupirocin; D000069349:Linezolid; C106791:telithromycin