title: Ultrasonic tissue characterization of atherosclerosis by a speed-of-sound microscanning system.
abstract: We have been developing a scanning acoustic microscope (SAM) system for medicine and biology featuring quantitative measurement of ultrasonic parameters of soft tissues. In the present study, we propose a new concept sound speed microscopy that can measure the thickness and speed of sound in the tissue using fast Fourier transform of a single pulsed wave instead of burst waves used in conventional SAM systems. Two coronary arteries were frozen and sectioned approximately 10 microm in thickness. They were mounted on glass slides without cover slips. The scanning time of a frame with 300 x 300 pixels was 90 s and two-dimensional distribution of speed of sound was obtained. The speed of sound was 1680 +/- 30 m/s in the thickened intima with collagen fiber, 1520 +/- 8 m/s in the lipid deposition underlying the fibrous cap, and 1810 +/- 25 m/s in a calcified lesion in the intima. These basic measurements will help in the understanding of echo intensity and pattern in intravascular ultrasound images.
authors: Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai 980-8575, Japan. saijo@idac.tohoku.ac.jp
authors: Yoshifumi
authors: Y
authors: Saijo
authors: Esmeraldo
authors: E
authors: Santos Filho
authors: Hidehiko
authors: H
authors: Sasaki
authors: Tomoyuki
authors: T
authors: Yambe
authors: Motonao
authors: M
authors: Tanaka
authors: Naohiro
authors: N
authors: Hozumi
authors: Kazuto
authors: K
authors: Kobayashi
authors: Nagaya
authors: N
authors: Okada
mesh_terms: D000465:Algorithms; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000295:instrumentation / Q000379:methods; D033401:Microscopy, Acoustic / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D014159:Transducers; D018084:Ultrasonography, Interventional / Q000295:instrumentation* / Q000379:methods*