title: Bone marker status in mothers and their newborns in Iran.
abstract: OBJECTIVE
  The contribution of maternal skeletal calcium metabolism in pregnancy is evidenced in changes in the markers of bone formation and bone resorption. Changes in maternal bone markers could affect fetal bone mineralization. The aim of this study was to determine the association between maternal and cord blood bone markers.
  
  
  METHODS
  Five hundred and fifty-two pregnant women were recruited from Tehran University educating hospitals in the winter of 2002. Maternal and cord blood samples were taken at delivery. The serum was assayed for osteocalcin and crosslaps, calcium, and parathyroid hormone.
  
  
  RESULTS
  There was significant correlation between maternal and cord blood serum osteocalcin and crosslaps levels, and the mean cord blood levels of osteocalcin and crosslaps were significantly higher at about 1.59- and 1.62-fold maternal levels, respectively. Serum calcium levels strongly correlated with osteocalcin and crosslaps in mothers (r = 0.21, p = 0.001 and r = 0.25, p = 0.001, respectively).
  
  
  CONCLUSIONS
  Skeletal calcium release may play a major role in calcium homeostasis during pregnancy. Because of this, calcium supplements could have an important role in pregnant women in decreasing the risk of subsequent complications such as osteoporosis.
authors: Endocrinology and Metabolism Research Center, Medical Sciences, University of Tehran, Tehran, Iran.
authors: Zhila
authors: Z
authors: Maghbooli
authors: Arash
authors: A
authors: Hossein-Nezhad
authors: Mohsen Khoshniat
authors: MK
authors: Nikoo
authors: Ali R
authors: AR
authors: Shafei
authors: Mazaher
authors: M
authors: Rahmani
authors: Bagher
authors: B
authors: Larijani
mesh_terms: D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism*; D002112:Calcifediol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007231:Infant, Newborn; D007492:Iran; D009035:Mothers; D015675:Osteocalcin / Q000097:blood; D011247:Pregnancy; D015995:Prevalence; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D015675:Osteocalcin; D002112:Calcifediol