title: Bisphenol-A and chlorinated derivatives in adipose tissue of women.
abstract: Bisphenol-A (BPA) and chlorinated derivatives (Cl(x)BPA) were investigated in adipose tissue of women in Southeast Spain. BPA was above limit of detection (LOD) in 11 out of 20 samples (55%). Among Cl(x)BPA, Cl(2)BPA was the most frequent (80%) and abundant, constituting 94.6% of total chlorinated BPA in adipose tissue. Mean +/- S.D. of BPA, monochloro-BPA (ClBPA), dichloro-BPA (Cl(2)BPA), and trichloro-BPA (Cl(3)BPA) were 5.83 +/- 3.48, 3.05 +/- 0.28, 9.21 +/- 9.26, and 0.74 +/- 0.15 ng/g of adipose tissue, respectively. No tetrachloro-BPA (Cl(4)BPA) was found above LOD. There are no published data on BPA in human adipose tissue or on Cl(x)BPA in adipose tissue or blood, limiting comparisons. BPA levels were similar (w/w) to findings in blood (w/v) in other populations and below levels reported in placenta tissue (w/w). Because of the estrogen mimicking effects of BPA and its Cl(x)BPA, further research is needed to explore their combined effects on human health and trends in human exposure.
authors: Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, 18071 Granada, Spain. marieta@ugr.es
authors: M F
authors: MF
authors: Fernandez
authors: J P
authors: JP
authors: Arrebola
authors: J
authors: J
authors: Taoufiki
authors: A
authors: A
authors: Navalón
authors: O
authors: O
authors: Ballesteros
authors: R
authors: R
authors: Pulgar
authors: J L
authors: JL
authors: Vilchez
authors: N
authors: N
authors: Olea
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D000367:Age Factors; D000368:Aged; D001559:Benzhydryl Compounds / Q000032:analysis / Q000737:chemistry; D015992:Body Mass Index; D002733:Chlorophenols / Q000032:analysis / Q000737:chemistry; D004781:Environmental Exposure / Q000032:analysis*; D004968:Estrogens, Non-Steroidal / Q000032:analysis / Q000737:chemistry; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008875:Middle Aged; D015394:Molecular Structure; D050177:Overweight; D010636:Phenols / Q000032:analysis* / Q000737:chemistry; D011078:Polychlorinated Biphenyls / Q000032:analysis* / Q000737:chemistry; D015203:Reproducibility of Results; D013030:Spain; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002733:Chlorophenols; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D011078:Polychlorinated Biphenyls; C497827:2,2-bis(3-chloro-4-hydroxyphenyl)propane; C524816:2-(3-chloro-4-hydroxyphenyl)-2-(3,5-dichloro-4-hydroxyphenyl)propane; C497826:2-(3-chloro-4-hydroxyphenyl)-2-(4-hydroxyphenyl)propane; C041181:tetrachlorodian; C006780:bisphenol A; D000098826:Bisphenol A Compounds