title: Evaluation of oxidative stress markers after vaginal delivery or Caesarean section.
abstract: BACKGROUND
  The effects of vaginal delivery (VD) and of cesarean section (CS) on the markers of oxidative stress were investigated.
  
  
  METHODS
  Umbilical blood samples were analyzed from 74 full-term neonates, 46 born via VD, 28 via elective CS. The level of lipid peroxidation (LP), protein and DNA damage and the antioxidant status were compared.
  
  
  RESULTS
  Differences between CS and VD groups were generally non-significant for oxidative markers, except for the GSH concentrations (VD: 4.18 vs. CS: 2.77 microM/mg protein x 10(-3); p<0.05). LP was significantly higher in the CS group (0.078 vs. 0.042 nM MDA/mg protein; p <0.05). The level of carbonyl proteins was high in the VD group and significantly lower in the elective CS group (9.5 vs. 8.1 mM/mg protein x 10(-4); p<0.05). We found 0.78% more strand breaks in elective CS group than in VD group.
  
  
  CONCLUSIONS
  CS does not have an advantage over VD with respect to oxidative stress.
authors: Department of Biochemistry and Molecular Biology, University of Szeged, H-6701 Szeged, Hungary. hracsko@bio.u-szeged.hu
authors: Zsuzsanna
authors: Z
authors: Hracsko
authors: Zsolt
authors: Z
authors: Safar
authors: Hajnalka
authors: H
authors: Orvos
authors: Zoltan
authors: Z
authors: Novak
authors: Attila
authors: A
authors: Pal
authors: Ilona S
authors: IS
authors: Varga
mesh_terms: D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism; D002585:Cesarean Section; D004249:DNA Damage; D036861:Delivery, Obstetric / Q000379:methods*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007743:Labor, Obstetric / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D018384:Oxidative Stress; D011247:Pregnancy
chemical_list: D015415:Biomarkers; D001798:Blood Proteins