title: Trivalent antigens for degranulation of mast cells.
abstract: Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.
authors: Department of Computational Biology, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA.
authors: Richard G
authors: RG
authors: Posner
authors: Dianliang
authors: D
authors: Geng
authors: Seth
authors: S
authors: Haymore
authors: James
authors: J
authors: Bogert
authors: Israel
authors: I
authors: Pecht
authors: Arieh
authors: A
authors: Licht
authors: Paul B
authors: PB
authors: Savage
mesh_terms: D000941:Antigens / Q000737:chemistry* / Q000145:classification* / Q000494:pharmacology; D015550:Cell Degranulation / Q000187:drug effects; D005453:Fluorescence; D006596:Hexosaminidases / Q000032:analysis; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D015394:Molecular Structure
chemical_list: D000941:Antigens; D006596:Hexosaminidases
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