title: [Analgesic effect of interleukin-2 in mouse models of spared nerve injury].
abstract: OBJECTIVE
  To investigate the analgesic effect of interleukin-2 (IL-2) in mice with spared nerve injury (SNI).
  
  
  METHODS
  IL-2 was intraperitoneally injected in mice with induced SNI, and von Frey Filaments test and cold plate test were carried out to accesses the analgesic effects of IL-2 and the effect of naloxone in antagonizing the effects of IL-2.
  
  
  RESULTS
  IL-2 produced analgesic effects against hyperalgesia and allodynia in mouse models of SNI, and the effect of IL-2 lasted for more than 24 h, showing a double-peak pattern in its action with the two peaks occurring at 30 and 105 min, respectively. The effect of IL-2 could be significantly antagonized by naloxone.
  
  
  CONCLUSIONS
  IL-2 has long-lasting analgesic effects in mouse models of SNI model, showing a double-peak pattern of its action. The analgesic effect of IL-2 is probably mediated by opiate receptor.
authors: Department of Immunology and Microbiology, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. llllllandsss@sohu.com
authors: Shan
authors: S
authors: Liu
authors: Lin
authors: L
authors: Shi
authors: Jun-Yang
authors: JY
authors: Wang
authors: Gui-Xiang
authors: GX
authors: Fan
authors: Yu-Kang
authors: YK
authors: Yuan
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006930:Hyperalgesia / Q000150:complications / Q000188:drug therapy; D007376:Interleukin-2 / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009270:Naloxone / Q000494:pharmacology; D020196:Trauma, Nervous System / Q000150:complications / Q000188:drug therapy*
chemical_list: D000700:Analgesics; D007376:Interleukin-2; D009270:Naloxone