title: Isovolumic relaxation flow propagation velocity: a promising load-independent relaxation parameter in hemodialysis patients.
abstract: The aim of this study is to evaluate whether isovolumic relaxation flow propagation velocity (IRFPV), a newly proposed relaxation parameter, is independent of load alterations. Thirty-nine uremic patients (21 men; age 62 +/- 10 y) who underwent echocardiography 1 h before and 1 h after hemodialysis (HD) were included. After HD, body weight, systolic blood pressure, early transmitral filling wave velocity (E), early diastolic mitral annular velocity (Ea) and early diastolic inflow propagation velocity (EPV) decreased significantly (p <or= 0.007), while IRFPV kept constant (p = 0.550). A subgroup analysis showed that in patients with body weight reduction <2.5 kg, E (p = 0.005) decreased significantly, but Ea (p = 0.078), EPV (p = 0.155) and IRFPV (p = 0.324) did not change after HD. In patients with body weight reduction >or=2.5 kg, E (p < 0.001), Ea (p = 0.001) and EPV (p = 0.001) decreased significantly but IRFPV (p = 0.715) was still constant after HD. In conclusion, IRFPV may be a load-independent parameter in assessing left ventricular diastolic function. However, Ea and EPV are load-independent only at minor load alterations. In evaluating left ventricular diastolic function in HD patients whose loading conditions frequently vary with time, IRFPV seems to be more adequate than Ea and EPV.
authors: Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Ho-Ming
authors: HM
authors: Su
authors: Tsung-Hsien
authors: TH
authors: Lin
authors: Wen-Chol
authors: WC
authors: Voon
authors: Hung-Chun
authors: HC
authors: Chen
authors: Jer-Ming
authors: JM
authors: Chang
authors: Kun-Tai
authors: KT
authors: Lee
authors: Chih-Sheng
authors: CS
authors: Chu
authors: Kai-Hung
authors: KH
authors: Cheng
authors: Wen-Ter
authors: WT
authors: Lai
authors: Sheng-Hsiung
authors: SH
authors: Sheu
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003971:Diastole; D015150:Echocardiography, Doppler; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D006435:Renal Dialysis; D016277:Ventricular Function, Left; D015431:Weight Loss