[Hypertension and cardiac failure].
Arterial hypertension is the leading cause of mortality and morbidity with a worldwide prevalence of 26%. Aging increases the incidence of arterial hypertension. Arterial hypertension is the prime example for a chronic disease with asymptomatic beginning, creeping course and fatal outcome. Arterial hypertension is a major cardiovascular risk factor and leads to vascular as well as myocardial manifestations: coronary artery disease, hypertensive microvascular disease, concentric left ventricular hypertrophy as well as perivascular and interstitial fibrosis. In the late stages of the disease, hypertrophy and cardiac failure develop. Arterial hypertension is the leading cause of coronary artery disease and cardiac failure, and coronary artery disease is the cause of heart failure in 50% of cases. Various non-invasive and invasive procedures are available for screening and follow-up. The primary therapeutic target is to reverse cardiac manifestations of arterial hypertension using specific therapeutic algorithms as well as lowering blood pressure. This article covers the pathophysiology of arterial hypertension and cardiac failure, clinical symptoms, diagnostic options and therapeutical goals as well as medicinal options.
Schannwell
C M
CM
Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Deutschland. schannw@uni-duesseldorf.de
Hennersdorf
M G
MG
Strauer
B E
BE
D002303:Cardiac Output, Low / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D006333:Heart Failure / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*
J Hypertens. 1995 Jan;13(1):155-60
7759846
J Am Coll Cardiol. 1998 Jun;31(7):1635-40
9626845
Am Heart J. 1992 May;123(5):1337-67
1575152
Hypertension. 1996 Jul;28(1):22-30
8675258
Blood Press Suppl. 1997;2:6-12
9495619
Internist (Berl). 2005 May;46(5):496-508
15806411
J Hypertens. 1999 Feb;17(2):151-83
10067786
Circulation. 2002 Mar 26;105(12):1503-8
11914262
Circulation. 1993 May;87(5 Suppl):IV66-72
8485835
Am Heart J. 2002 Dec;144(6):1057-64
12486431
Am J Cardiol. 1979 Oct;44(4):730-40
158304
Lancet. 2002 Mar 23;359(9311):995-1003
11937178
J Hypertens. 1998 Sep;16(9):1221-33
9746107
Lancet. 2003 Sep 6;362(9386):777-81
13678871
Internist (Berl). 2003 Jul;44(7):793-4, 797-805
14631576
J Am Coll Cardiol. 1994 Feb;23(2):393-400
8294693
Herz. 2004 May;29(3):255-65
15167951
Am J Cardiol. 1996 Oct 15;78(8):890-5
8888661
Z Kardiol. 2005 Aug;94(8):488-509
16049651
Dtsch Med Wochenschr. 2001 Mar 9;126(10 ):263-7
11285760
N Engl J Med. 1991 Aug 1;325(5):303-10
2057035
N Engl J Med. 1992 Sep 3;327(10):669-77
1386652
Ann Intern Med. 1991 Mar 1;114(5):345-52
1825164
Circulation. 1987 Jan;75(1 Pt 2):I48-55
3791619
Circulation. 1996 Dec 1;94(11):2800-6
8941105
Am J Hypertens. 1998 Jul;11(7):879-81
9683053
JAMA. 2002 Sep 25;288(12):1491-8
12243636
J Am Coll Cardiol. 1990 Mar 15;15(4):775-83
2307786
Herz. 2003 Dec;28(8):764-78
14689112
Circulation. 1993 Jul;88(1):107-15
8319323
J Hypertens. 2001 Feb;19(2):167-77
11212958
Am J Cardiol. 1979 Oct 22;44(5):999-1006
158975
J Nucl Med. 1990 Mar;31(3):255-8
2137873
Circulation. 1996 Dec 15;94(12 ):3115-22
8989118
J Hypertens. 2002 Jul;20(7):1275-6
12131518
Herz. 1995 Apr;20(2):109-17
7774862
N Engl J Med. 1992 Sep 3;327(10 ):685-91
1463530
Circulation. 1993 Sep;88(3):993-1003
8353927
Hypertension. 1984 Nov-Dec;6(6 Pt 2):III4-12
6240452
Z Kardiol. 2001 Dec;90(12):946-52
11826836
J Card Fail. 1995 Dec;1(5):371-80
12836712
Internist (Berl). 2000 Mar;41(3):253-60
10789088
Nephrol Dial Transplant. 1998 Mar;13(3):564-9
9550628
JAMA. 1996 May 22-29;275(20):1557-62
8622246
Circulation. 2002 Mar 19;105(11):1387-93
11901053
Herz. 2005 Feb;30(1):26-36
15754153
Dtsch Med Wochenschr. 1998 Aug 14;123(33):957-64
9739343