Occlusion of iatrogenic pseudoaneurysms with percutaneous ultrasound guided thrombin injection.
BACKGROUND
Pseudoaneurysm is a common complication of cardiac catheterization and coronary intervention with an incidence of 2% even in experienced centers.


METHODS
In a feasibility study conducted between December 2004 and February 2006 we enrolled 76 patients consecutively to receive local thrombin injection (mean 329 IU; range 100-800 IU) into the aneurysma sac.


RESULTS
Ultrasound guided thrombotic occlusion of pseudoaneurysms was successful after one injection in 83% of the patients, 17% of the patients required more than one injection. The overall success rate of the procedure was 98,9%. No peripheral embolisation of thrombin was noted during any injection and we registered no other complication that needed any further intervention.


CONCLUSIONS
We conclude that ultrasound guided occlusion of pseudoaneurysms using thrombin injection with a success rate of the procedure of 98,9% is feasible and safe.
Freund
G
G
Department of Cardiology/Angiology, University Clinics of Freiburg, Germany. freund@medizin.ukl.uni-freiburg.de
Dürschmied
D
D
Zhou
Q
Q
Richter
S
S
Macharzina
R
R
Haas
R
R
Becherer
A
A
Bode
C
C
Hehrlein
C
C
D000368:Aged; D000369:Aged, 80 and over; D017541:Aneurysm, False / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D000800:Angioplasty, Balloon / Q000009:adverse effects; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D006328:Cardiac Catheterization / Q000009:adverse effects; D017023:Coronary Angiography / Q000009:adverse effects; D005240:Feasibility Studies; D005260:Female; D005263:Femoral Artery / Q000293:injuries*; D006801:Humans; D007049:Iatrogenic Disease; D007267:Injections; D008297:Male; D008875:Middle Aged; D013917:Thrombin / Q000008:administration & dosage*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
D013917:Thrombin