title: Identification, biological activity, and mechanism of the anti-ischemic quinolone analog.
abstract: The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed that the anti-ischemic activity might exert via an anti-apoptotic pathway, which implies its therapeutic uses against the ischemic cell injuries including ischemic stroke and ischemic heart disease.
authors: College of Pharmacy, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea.
authors: Chan-Hee
authors: CH
authors: Park
authors: Jongwon
authors: J
authors: Lee
authors: Hwi Young
authors: HY
authors: Jung
authors: Min Ji
authors: MJ
authors: Kim
authors: Sun Ha
authors: SH
authors: Lim
authors: Hyung Tae
authors: HT
authors: Yeo
authors: Eung Chil
authors: EC
authors: Choi
authors: Eun Jeong
authors: EJ
authors: Yoon
authors: Kyu Won
authors: KW
authors: Kim
authors: Jong Ho
authors: JH
authors: Cha
authors: Seok-Ho
authors: SH
authors: Kim
authors: Dong-Jo
authors: DJ
authors: Chang
authors: Do-Yeon
authors: DY
authors: Kwon
authors: Funan
authors: F
authors: Li
authors: Young-Ger
authors: YG
authors: Suh
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D002545:Brain Ischemia / Q000188:drug therapy / Q000473:pathology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D011804:Quinolines; C037219:quinoline