title: Treatment of wide-necked intracranial aneurysms with a novel self-expanding two-zonal endovascular stent device.
abstract: BACKGROUND
  Endovascular treatment of intracerebral wide-necked aneurysms carries the risk of incomplete embolisation and recanalisation of the aneurysm as well as coil protrusion into the parent artery and embolic complications. We present preliminary results with the placement of a novel tightly braided stent across the aneurysm neck which might lead to thrombosis of these aneurysms.
  
  
  METHODS
  A bifurcation artery aneurysm was created in a male New Zealand White Rabbit. After 4 weeks, a novel highly flexible stent with a central tightly braided mesh was placed across the aneurysm neck. Diagnostic angiography was performed during the procedure and immediately after stent deployment as well as 2 and 4 weeks following stent placement. Histological analyses, including microscopic investigations for evaluating intra-aneurysmal thrombosis and proliferation of the intima, were performed after 1 month.
  
  
  RESULTS
  Intra-aneurysmal flow reduction due to stent placement was achieved as early as 45 min after deployment. Unchanged complete occlusion of the aneurysm could be observed by angiography 2 and 4 weeks post-stent deployment. Histological analysis confirmed angiographical findings of complete aneurysm occlusion and excluded significant neointimal coverage.
  
  
  CONCLUSIONS
  This newly designed flexible stent may offer the potential to expand endovascular treatment of wide-necked intracranial aneurysms.
authors: Clinic for Diagnostic and Interventional Neuroradiology, Saarland-University, School of Medicine, 66421 Homburg, Germany. frah1@gmx.de
authors: Frank
authors: F
authors: Ahlhelm
authors: Christian
authors: C
authors: Roth
authors: Ralf
authors: R
authors: Kaufmann
authors: Gernot
authors: G
authors: Schulte-Altedorneburg
authors: Bernd F M
authors: BF
authors: Romeike
authors: Wolfgang
authors: W
authors: Reith
mesh_terms: D015901:Angiography, Digital Subtraction; D000818:Animals; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D002533:Cerebral Angiography; D004195:Disease Models, Animal; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D011474:Prosthesis Design; D011817:Rabbits; D015607:Stents
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