title: Very prematurely born infants wheezing at follow-up: lung function and risk factors.
abstract: OBJECTIVE
  To determine whether abnormalities of lung volume and/or airway function were associated with wheeze at follow-up in infants born very prematurely and to identify risk factors for wheeze.
  
  
  METHODS
  Lung function data obtained at 1 year of age were collated from two cohorts of infants recruited into the UKOS and an RSV study, respectively.
  
  
  METHODS
  Infant pulmonary function laboratory.
  
  
  METHODS
  111 infants (mean gestational age 26.3 (SD 1.6) weeks).
  
  
  METHODS
  Lung function measurements at 1 year of age corrected for gestational age at birth. Diary cards and respiratory questionnaires were completed to document wheeze.
  
  
  METHODS
  Functional residual capacity (FRC(pleth) and FRC(He)), airways resistance (R(aw)), FRC(He):FRC(pleth) and tidal breathing parameters (T(PTEF):T(E)).
  
  
  RESULTS
  The 60 infants who wheezed at follow-up had significantly lower mean FRC(He), FRC(He):FRC(pleth) and T(PTEF):T(E), but higher mean R(aw) than the 51 without wheeze. Regression analysis demonstrated that gestational age, length at assessment, family history of atopy and a low FRC(He):FRC(pleth) were significantly associated with wheeze.
  
  
  CONCLUSIONS
  Wheeze at follow-up in very prematurely born infants is associated with gas trapping, suggesting abnormalities of the small airways.
authors: MRC-Asthma Centre, Division of Asthma, Allergy and Lung Biology, King's College London, London, UK.
authors: Simon
authors: S
authors: Broughton
authors: Mark R
authors: MR
authors: Thomas
authors: Louise
authors: L
authors: Marston
authors: Sandra A
authors: SA
authors: Calvert
authors: Neil
authors: N
authors: Marlow
authors: Janet L
authors: JL
authors: Peacock
authors: Gerrard F
authors: GF
authors: Rafferty
authors: Anne
authors: A
authors: Greenough
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D005652:Functional Residual Capacity; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D012120:Respiration Disorders / Q000209:etiology* / Q000503:physiopathology; D012135:Respiratory Sounds / Q000209:etiology*; D012307:Risk Factors
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