Early intervention for the ocular and neurodevelopmental sequelae of Fetal Valproate Syndrome.
The established teratogenicity of antiepileptic drugs raises important issues in women of child-bearing age. While the association between neural tube defects and antiepileptic drugs is well recognised, other congenital malformations are known to occur. We report two siblings with characteristic craniofacial features of Fetal Valproate Syndrome who also had associated ocular and neurodevelopmental problems which would benefit from early recognition and intervention.
Carrim
Zia I
ZI
Department of Ophthalmology and Orthoptics, Southern General Hospital, and Royal Hospital for Sick Children, Glasgow, UK. zia.carrim@doctors.org.uk
McKay
Lorna
L
Sidiki
Sikander S
SS
Lavy
Timothy E
TE
D000014:Abnormalities, Drug-Induced; D000550:Amblyopia / Q000209:etiology; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D001321:Autistic Disorder / Q000209:etiology*; D002675:Child, Preschool; D019465:Craniofacial Abnormalities / Q000209:etiology / Q000601:surgery; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D016896:Treatment Outcome; D006113:United Kingdom; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects*
D000927:Anticonvulsants; D014635:Valproic Acid