title: Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression.
abstract: Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Moreover, accumulated clinical and experimental data indicate that the outcome of an immune response toward an evolving breast neoplasm is largely determined by the type of immune response elicited. Acute tumor-directed immune responses involving cytolytic T lymphocytes appear to protect against tumor development, whereas immune responses involving chronic activation of humoral immunity, infiltration by Th2 cells, and protumor-polarized innate inflammatory cells result in the promotion of tumor development and disease progression. Herein we review this body of literature and summarize important new findings revealing the paradoxical role of innate and adaptive leukocytes as regulators of breast carcinogenesis.
authors: Department of Pathology, University of California, San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA.
authors: David G
authors: DG
authors: DeNardo
authors: Lisa M
authors: LM
authors: Coussens
mesh_terms: D001943:Breast Neoplasms / Q000276:immunology*; D018450:Disease Progression; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology
references: J Immunol. 1998 Jun 15;160(12):5869-73
references: 9637498
references: Breast Cancer Res Treat. 1998;51(3):195-208
references: 10068079
references: Curr Opin Immunol. 2002 Dec;14(6):798-802
references: 12413532
references: Cancer Res. 1998 Aug 15;58(16):3491-4
references: 9721846
references: Stem Cells. 1995 Sep;13(5):487-500
references: 8528098
references: J Histochem Cytochem. 2001 Aug;49(8):1061-2
references: 11457936
references: Nat Rev Cancer. 2002 May;2(5):373-82
references: 12044013
references: J Immunol. 1997 Apr 1;158(7):3359-65
references: 9120294
references: Am J Epidemiol. 2001 Sep 15;154(6):544-56
references: 11549560
references: Annu Rev Immunol. 2001;19:275-90
references: 11244038
references: Clin Immunol. 2004 Sep;112(3):258-67
references: 15308119
references: Immunol Today. 1999 Apr;20(4):158-60
references: 10203710
references: J Immunol. 2005 Oct 1;175(7):4180-3
references: 16177055
references: Cancer. 1979 Dec;44(6):2083-9
references: 92359
references: Nature. 2006 May 25;441(7092):431-6
references: 16724054
references: Anticancer Res. 1992 Sep-Oct;12(5):1463-6
references: 1332579
references: Clin Exp Rheumatol. 2007 Mar-Apr;25(2):318-28
references: 17543163
references: Cancer Res. 1957 Jan;17(1):2-10
references: 13413828
references: J Clin Immunol. 1983 Oct;3(4):295-315
references: 6140268
references: Contrib Microbiol. 2006;13:118-37
references: 16627962
references: Cancer Res. 2001 Nov 15;61(22):8298-305
references: 11719463
references: Nat Med. 2004 Sep;10(9):942-9
references: 15322536
references: Nat Rev Cancer. 2006 Jan;6(1):24-37
references: 16397525
references: J Pathol. 2002 Mar;196(3):254-65
references: 11857487
references: Int Immunol. 2001 Apr;13(4):459-63
references: 11282985
references: Cancer Res. 2001 Nov 1;61(21):7889-99
references: 11691809
references: J Immunol. 1999 Oct 15;163(8):4109-13
references: 10510345
references: N Engl J Med. 2003 Nov 13;349(20):1968-71; author reply 1968-71
references: 14614174
references: Nat Rev Cancer. 2005 Apr;5(4):263-74
references: 15776005
references: Int J Cancer. 1995 Jan 17;60(2):183-9
references: 7829213
references: J Immunol. 2001 Jan 1;166(1):678-89
references: 11123353
references: Nature. 2002 Dec 19-26;420(6917):860-7
references: 12490959
references: Liver Transpl. 2001 Nov;7(11 Suppl 1):S109-18
references: 11689783
references: Immunity. 2004 Aug;21(2):137-48
references: 15308095
references: Cancer Immunol Immunother. 1994 Apr;38(4):225-32
references: 8168117
references: Clin Exp Immunol. 2003 Nov;134(2):169-77
references: 14616773
references: Cancer Lett. 1992 Jan 10;61(2):157-64
references: 1730139
references: Annu Rev Immunol. 1993;11:331-60
references: 8476565
references: Trends Immunol. 2002 Nov;23(11):549-55
references: 12401408
references: Curr Opin Immunol. 2007 Apr;19(2):209-16
references: 17276050
references: Tumori. 1986 Feb 28;72(1):43-51
references: 3006307
references: Semin Cancer Biol. 2000 Oct;10(5):351-7
references: 11100883
references: J Immunol. 2001 May 1;166(9):5398-406
references: 11313376
references: Oncol Rep. 1998 May-Jun;5(3):753-61
references: 9538189
references: Cancer Cell. 2004 Nov;6(5):447-58
references: 15542429
references: Cancer Res. 2003 Aug 1;63(15):4516-20
references: 12907625
references: Cancer Cell. 2004 Oct;6(4):409-21
references: 15488763
references: J Histochem Cytochem. 1996 Feb;44(2):187-91
references: 8609376
references: Front Biosci. 2006;11:1360-70
references: 16368522
references: Eur J Clin Invest. 2003 May;33(5):420-5
references: 12760367
references: Gastric Cancer. 1999 May;2(1):26-32
references: 11957067
references: Lancet. 1995 Sep 23;346(8978):796-8
references: 7674744
references: Transplant Proc. 1999 Feb-Mar;31(1-2):1260-2
references: 10083562
references: N Engl J Med. 2003 Apr 24;348(17):1681-91
references: 12711744
references: J Immunol. 1998 Sep 15;161(6):3033-41
references: 9743368
references: Clin Immunol Rev. 1981;1(1):119-214
references: 6219849
references: J Clin Pathol. 2004 Jun;57(6):630-6
references: 15166270
references: Eur J Cancer. 1992;28A(4-5):859-64
references: 1524909
references: Science. 2006 Sep 29;313(5795):1960-4
references: 17008531
references: Cancer Res. 1958 Oct;18(9):992-1003
references: 13596939
references: Nat Rev Immunol. 2005 Oct;5(10):749-59
references: 16175180
references: Cancer Cell. 2005 May;7(5):411-23
references: 15894262
references: Int Rev Immunol. 2006 Sep-Dec;25(5-6):377-413
references: 17169781
references: J Clin Endocrinol Metab. 1994 Feb;78(2):348-52
references: 8106623
references: J Exp Med. 2001 Mar 19;193(6):F23-6
references: 11257144
references: J Cell Biochem. 2007 Jul 1;101(4):918-26
references: 17265430
references: Cancer. 1982 Apr 1;49(7):1456-64
references: 6277465
references: Cancer Res. 1986 Apr;46(4 Pt 2):2121-6
references: 3081262
references: Genes Dev. 1999 Jun 1;13(11):1382-97
references: 10364156
references: J Clin Invest. 1998 Sep 1;102(5):938-46
references: 9727062
references: Curr Opin Immunol. 2007 Apr;19(2):224-31
references: 17303400
references: Cancer Lett. 2005 Dec 18;230(2):187-98
references: 16297705
references: Cancer Immunol Immunother. 2004 Feb;53(2):64-72
references: 14593498
references: Pathol Res Pract. 1988 Jun;183(3):356-64
references: 3047716
references: Lancet. 2001 Feb 17;357(9255):539-45
references: 11229684
references: Neoplasia. 1999 Nov;1(5):453-60
references: 10933061
references: PLoS Med. 2005 Sep;2(9):e284
references: 16124834
references: Nat Rev Cancer. 2004 Jan;4(1):71-8
references: 14708027
references: J Exp Med. 2000 Jun 5;191(11):1945-56
references: 10839809
references: Eur J Immunol. 2005 Aug;35(8):2452-8
references: 15997468
references: J Surg Oncol. 2005 Jan 1;89(1):23-7
references: 15612013
references: Cancer Immunol Immunother. 1996 Jan;42(1):1-8
references: 8625361
references: Immunol Today. 1997 Jun;18(6):263-6
references: 9190109
references: J Immunol. 2000 Mar 1;164(5):2782-9
references: 10679121
references: J Clin Oncol. 1997 Nov;15(11):3363-7
references: 9363867
references: J Immunol. 1999 Mar 1;162(5):3053-62
references: 10072558
references: J Clin Oncol. 2006 Dec 1;24(34):5373-80
references: 17135638
references: J Pathol. 1997 Feb;181(2):200-6
references: 9120726
references: Eur J Cancer. 2004 Jul;40(11):1660-7
references: 15251154
references: N Engl J Med. 2003 Aug 7;349(6):546-53
references: 12904519
references: Blood. 2002 Sep 1;100(5):1728-33
references: 12176894
references: J Immunol. 2000 Dec 1;165(11):6024-8
references: 11086033
references: Eur Respir J. 2000 Jun;15(6):1087-93
references: 10885428
references: Breast Cancer Res Treat. 1985;6(1):57-65
references: 3902126
references: Nature. 2006 Jul 6;442(7098):39-44
references: 16823444
references: J Neuroimmunol. 2002 Sep;130(1-2):10-21
references: 12225884
references: Curr Opin Immunol. 2003 Jun;15(3):354-61
references: 12787764
references: Eur Respir J Suppl. 1995 Sep;20:668s-675s
references: 8590567
references: Cancer Res. 2006 Dec 1;66(23):11238-46
references: 17114237
references: J Invest Dermatol. 1997 Jun;108(6):914-9
references: 9182821
references: J Exp Med. 2001 Mar 19;193(6):727-40
references: 11257139
references: Novartis Found Symp. 2004;256:158-68; discussion 168-72, 259-69
references: 15027489
references: J Immunol. 2000 Dec 1;165(11):6015-9
references: 11086031
references: Immunol Lett. 1988 Jul;18(3):181-9
references: 3169848
references: J Surg Res. 1998 Apr;76(1):95-103
references: 9695747
references: Cancer Immunol Immunother. 2003 Dec;52(12):715-38
references: 12920480
references: Surg Gynecol Obstet. 1975 Jun;140(6):919-24
references: 1129683
references: Expert Opin Biol Ther. 2004 Dec;4(12):1887-96
references: 15571451
references: Ann Thorac Surg. 1995 Dec;60(6):1623-6
references: 8787454
references: Cancer Cell. 2005 Mar;7(3):211-7
references: 15766659
references: Cancer Res. 2002 Dec 1;62(23):7042-9
references: 12460925
references: J Immunol. 1989 Feb 1;142(3):760-5
references: 2464024