title: Noise-limited frequency signal transmission in gene circuits.
abstract: To maintain normal physiology, cells must properly process diverse signals arising from changes in temperature, pH, nutrient concentrations, and other factors. Many physiological processes are controlled by temporal aspects of oscillating signals; that is, these signals can encode information in the frequency domain. By modeling simple gene circuits, we analyze the impact of cellular noise on the fidelity and speed of frequency-signal transmission. We find that transmission of frequency signals is "all-or-none", limited by a critical frequency (f(c)). Signals with frequencies <f(c) are transmitted with high fidelity, whereas those with frequencies >f(c) are severely corrupted or completely lost in transmission. We argue that f(c) is an intrinsic property of a gene circuit and it varies with circuit parameters and additional feedback or feedforward regulation. Our results may have implications for understanding signal processing in natural biological networks and for engineering synthetic gene circuits.
authors: Department of Biomedical Engineering, and Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA.
authors: Cheemeng
authors: C
authors: Tan
authors: Faisal
authors: F
authors: Reza
authors: Lingchong
authors: L
authors: You
mesh_terms: D001683:Biological Clocks / Q000502:physiology*; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D008954:Models, Biological; D015233:Models, Statistical; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D020543:Proteome
references: J Clin Psychiatry. 2005;66 Suppl 9:3-9; quiz 42-3
references: 16336035
references: Development. 1995 May;121(5):1533-45
references: 7789282
references: Development. 1995 Oct;121(10):3291-301
references: 7588063
references: Development. 1997 Mar;124(6):1169-78
references: 9102304
references: Nature. 1997 Apr 24;386(6627):759-60
references: 9126727
references: Cell. 1997 Nov 28;91(5):639-48
references: 9393857
references: Nature. 1998 Apr 30;392(6679):933-6
references: 9582075
references: Nature. 1998 Apr 30;392(6679):936-41
references: 9582076
references: Curr Biol. 1998 Sep 10;8(18):1027-30
references: 9740806
references: Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4971-6
references: 10220403
references: Annu Rev Physiol. 2005;67:1-21
references: 15709950
references: J Cell Biol. 2005 Feb 14;168(4):533-6
references: 15716374
references: Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3581-6
references: 15738412
references: Science. 2005 Mar 25;307(5717):1962-5
references: 15790856
references: Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):347-52
references: 16387859
references: J Neurosci. 2000 Jan 15;20(2):617-25
references: 10632591
references: Nature. 2000 Jan 20;403(6767):267-8
references: 10659837
references: Nature. 2000 Jan 20;403(6767):335-8
references: 10659856
references: Development. 2000 Apr;127(7):1421-9
references: 10704388
references: Nature. 2000 Jun 1;405(6786):590-3
references: 10850721
references: Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10101-6
references: 10963673
references: Nature. 2000 Nov 23;408(6811):475-9
references: 11100729
references: Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8614-9
references: 11438714
references: Annu Rev Cell Dev Biol. 2001;17:215-53
references: 11687489
references: Funct Integr Genomics. 2000 Nov;1(3):186-92
references: 11793236
references: Clin Genet. 2001 Dec;60(6):409-16
references: 11846732
references: Mol Biol Rep. 2001;28(2):73-82
references: 11931391
references: Phys Rev Lett. 2002 Apr 8;88(14):148101
references: 11955179
references: Nat Genet. 2002 May;31(1):69-73
references: 11967532
references: Dev Cell. 2002 Jul;3(1):63-74
references: 12110168
references: J Mol Biol. 2002 Nov 8;323(5):785-93
references: 12417193
references: Nature. 2002 Nov 14;420(6912):231-7
references: 12432408
references: Nature. 2003 Apr 10;422(6932):633-7
references: 12687005
references: Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4551-6
references: 12671069
references: J Mol Biol. 2003 Jun 13;329(4):645-54
references: 12787666
references: Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29
references: 12838335
references: Science. 2003 Jul 18;301(5631):328-30
references: 12869750
references: EMBO J. 2003 Aug 1;22(15):3825-32
references: 12881417
references: Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):11980-5
references: 14530388
references: Nature. 2004 Jan 29;427(6973):415-8
references: 14749823
references: Nat Genet. 2004 Feb;36(2):147-50
references: 14730303
references: Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1200-5
references: 14734811
references: Nat Cell Biol. 2004 May;6(5):451-7
references: 15107861
references: Science. 2004 May 14;304(5673):983-7
references: 15087506
references: Science. 2004 Oct 22;306(5696):704-8
references: 15499023
references: Nature. 2006 Feb 2;439(7076):608-11
references: 16452980
references: Nature. 2006 Feb 16;439(7078):861-4
references: 16372021
references: Nature. 2006 Jun 22;441(7096):1011-4
references: 16791200
references: Syst Biol (Stevenage). 2006 Mar;153(2):46-52
references: 16986252
references: PLoS Comput Biol. 2006 Nov 17;2(11):e154
references: 17112312
references: PLoS Comput Biol. 2006 Sep 1;2(9):e116
references: 16948530
references: Mol Biosyst. 2007 May;3(5):343-53
references: 17460793
references: Nature. 1974 Dec 13;252(5484):546-9
references: 4431516
references: Nature. 1976 Aug 5;262(5568):467-71
references: 958399
references: Science. 1993 Apr 2;260(5104):82-4
references: 8385366
references: Nature. 1995 Jan 5;373(6509):33-6
references: 7800036
references: Science. 2005 Mar 25;307(5717):1965-9
references: 15790857
references: Proc Natl Acad Sci U S A. 2005 May 17;102(20):7063-8
references: 15883385
references: Proc Natl Acad Sci U S A. 2005 May 24;102(21):7577-82
references: 15890781
references: Nat Rev Genet. 2005 Jun;6(6):451-64
references: 15883588
references: Bull Math Biol. 2005 Sep;67(5):901-46
references: 15998488
references: Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10040-5
references: 16006514
references: Science. 2005 Sep 23;309(5743):2010-3
references: 16179466
references: Nature. 2005 Sep 29;437(7059):699-706
references: 16170311
references: Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14338-43
references: 16176987