Crude ethanolic extract, lignoid fraction and yangambin from Ocotea duckei (Lauraceae) show antileishmanial activity.
Crude ethanolic extract, lignoid fraction and the purified compound yangambin were obtained from Ocotea duckei (Lauraceae) and their antileishmanial activity was tested against promastigote forms of Leishmania chagasi and Leishmania amazonensis cultivated in Schneider medium, supplemented with 20% of fetal bovine serum. All substances presented antileishmanial activity with IC50 values of 135.7 microg/mL for the crude ethanolic extract, 26.5 microg/mL for the lignoid fraction and 49.0 microg/mL for yangambin on L. chagasi. For L. amazonensis the IC50 values were 143.7 microg/mL, 48.2 microg/mL and 64.9 microg/mL for the crude ethanolic extract, the lignoid fraction, and the purified compound yangambin, respectively. The crude ethanolic extract, lignoid fraction, and yangambin caused an inhibition higher than Glucantime, a reference drug used for the treatment of leishmaniasis.
Monte
Rubens L Neto
RL
Laboratory of Pharmaceutical Technology, Federal University of Paraíba, 58051-970, João Pessoa, Paraíba, Brazil.
Barbosa
José M Filho
JM
Sousa
Louisa M A
LM
Athayde
Petrônio F Filho
PF
Dias
Celidarque S
CS
Oliveira
Márcia R
MR
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019770:Lauraceae / Q000737:chemistry*; D018314:Leishmania infantum / Q000187:drug effects*; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D005663:Furans; D017705:Lignans; D010936:Plant Extracts; C082827:epiyangambin; D000431:Ethanol