Gene profiles within the adult subventricular zone niche: proliferation, differentiation and migration of neural progenitor cells in the ischemic brain.
Focal cerebral ischemia induces neurogenesis in the subventricular zone (SVZ) of the adult human brain. Neurogenesis is controlled by proliferation, differentiation, and migration of neural progenitor cells. This article reviews emerging data that changes of cell cycle kinetics of neural progenitor cells induced by stroke contribute to increased neural progenitor cell proliferation and that gene profiles control proliferation, differentiation, and migration of neural progenitor cells within the SVZ niche. A better understanding of gene profiles that control the biological function of adult SVZ neural progenitor cells could lead to more selective and effective treatments to enhance neurogenesis during stroke recovery.
Zhang
Rui Lan
RL
Department of Neurology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Zhang
Zheng Gang
ZG
Chopp
Michael
M
D000328:Adult; D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D002552:Cerebral Ventricles / Q000166:cytology* / Q000378:metabolism*; D020869:Gene Expression Profiling; D006801:Humans; D009474:Neurons / Q000166:cytology*; D013234:Stem Cells / Q000166:cytology*