Microphthalmos associated with Dartmouth combination chemotherapy in pregnancy: a case report.
BACKGROUND
Use of Dartmouth combination chemotherapy in pregnancy is scarcely reported, with only 1 report of its use in the late second and third trimesters and no report of its use in the first trimester.


METHODS
This is the first reported case in which the Dartmouth combination chemotherapy regimen was inadvertently used in a pregnant woman during the first and second trimesters for treatment of metastatic melanoma. The infant was found to have isolated microphthalmos and severe hypermetropia at 1 year of age.


CONCLUSIONS
Although a causal relationship cannot be established from a single case, this report does provide useful information to discourage the use of this chemotherapy regimen in the first trimester, which is the critical period for organogenesis.
Li
Raymond Hang Wun
RH
Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, N.T., Hong Kong SAR, China.
Tam
Wing Hung
WH
Ng
Pak Cheung
PC
Mok
Tony Shu Kam
TS
Tam
Barbara
B
Lau
Tze Kin
TK
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002330:Carmustine / Q000009:adverse effects; D002945:Cisplatin / Q000009:adverse effects; D003606:Dacarbazine / Q000009:adverse effects; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary; D008850:Microphthalmos / Q000139:chemically induced*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011261:Pregnancy Trimester, First / Q000187:drug effects; D011262:Pregnancy Trimester, Second / Q000187:drug effects; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013629:Tamoxifen / Q000009:adverse effects
D013629:Tamoxifen; D003606:Dacarbazine; D002945:Cisplatin; D002330:Carmustine