title: Fertility, pregnancy and delivery in women after biventricular repair for double outlet right ventricle.
abstract: OBJECTIVE
  To investigate outcome of pregnancy and fertility in women with double outlet right ventricle (DORV).
  
  
  METHODS
  Using 2 congenital heart disease registries, 21 female patients with DORV (aged 18-39 years) were retrospectively identified. Detailed recordings of each patient and their completed (>20 weeks gestation) pregnancies were recorded.
  
  
  RESULTS
  Overall, 10 patients had 19 pregnancies, including 3 spontaneous miscarriages (16%). During the 16 live birth pregnancies, primarily (serious) noncardiac complications were observed, e.g. premature labor/delivery (n = 7 and n = 3, respectively), small for gestational age (n = 4), preeclampsia (n = 2) and recurrence of congenital heart disease (n = 2). Except for postpartum endocarditis and deterioration of subpulmonary obstruction, only mild cardiac complication pregnancies were recorded. Two women with children reported secondary female infertility. Several menstrual cycle disorders were reported: secondary amenorrhea (n = 4), primary amenorrhea (n = 3) and oligomenorrhea (n = 2).
  
  
  CONCLUSIONS
  Successful pregnancy in women with DORV is possible. Primarily noncardiac complications were observed and only few (minor) cardiac complications. Infertility and menstrual cycle disorders appear to be more prevalent.
authors: Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands. w.drenthen@thorax.umcg.nl
authors: Willem
authors: W
authors: Drenthen
authors: Petronella G
authors: PG
authors: Pieper
authors: Karin
authors: K
authors: van der Tuuk
authors: Jolien W
authors: JW
authors: Roos-Hesselink
authors: Elke S
authors: ES
authors: Hoendermis
authors: Adriaan A
authors: AA
authors: Voors
authors: Barbara J M
authors: BJ
authors: Mulder
authors: Arie P J
authors: AP
authors: van Dijk
authors: Sing C
authors: SC
authors: Yap
authors: Hubert W
authors: HW
authors: Vliegen
authors: Philip
authors: P
authors: Moons
authors: Tjark
authors: T
authors: Ebels
authors: Dirk J
authors: DJ
authors: van Veldhuisen
mesh_terms: D000328:Adult; D004310:Double Outlet Right Ventricle / Q000150:complications / Q000601:surgery; D005260:Female; D005298:Fertility; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008599:Menstruation Disturbances / Q000453:epidemiology / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications; D011249:Pregnancy Complications, Cardiovascular; D011256:Pregnancy Outcome; D015995:Prevalence; D012042:Registries; D012189:Retrospective Studies