title: Unified compaction curve model for tensile strength of tablets made by roller compaction and direct compression.
abstract: A model that describes the relationship between roller-compaction conditions and tablet strength is proposed. The model assumes that compaction is cumulative during roller compaction and subsequent granule compaction, and compact strength (ribbon and tablet) is generated irreversibly as if strength is controlled by plastic deformation of primary particles only. Roller-compaction is treated as a compaction step where the macroscopic ribbon strength is subsequently destroyed in milling. This loss in strength is irreversible and tablets compressed from the resulting granulation are weaker than those compressed by direct compression at the same compression force. Roller-compacted ribbons were produced at a range of roll forces for three formulations and subsequently milled and compacted into tablets. Once the total compaction history is taken in account, the compaction behavior of the uncompacted blends and the roller-compacted granules ultimately follow a single master compaction curve--a unified compaction curve (UCC). The model successfully described the compaction behavior of DC grade starch and formulations of lactose monohydrate with 50% or more microcrystalline cellulose, and may be more generally applicable to systems containing significant proportions of any plastically deforming material, including MCC and starch.
authors: Merck and Co. Inc., West Point, PA, USA. leon_farber@merck.com
authors: Leon
authors: L
authors: Farber
authors: Karen P
authors: KP
authors: Hapgood
authors: James N
authors: JN
authors: Michaels
authors: Xi-Young
authors: XY
authors: Fu
authors: Robert
authors: R
authors: Meyer
authors: Mary-Ann
authors: MA
authors: Johnson
authors: Feng
authors: F
authors: Li
mesh_terms: D002482:Cellulose / Q000737:chemistry; D004339:Drug Compounding; D007785:Lactose / Q000737:chemistry; D008956:Models, Chemical; D013607:Tablets / Q000737:chemistry*; D013718:Tensile Strength
chemical_list: D013607:Tablets; D002482:Cellulose; D007785:Lactose; C109691:microcrystalline cellulose