Bone morphogenetic protein.
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor-beta superfamily. It has been demonstrated that BMPs had been involved in the regulation of cell proliferation, survival, differentiation and apoptosis. However, their hallmark ability is that play a pivotal role in inducing bone, cartilage, ligament, and tendon formation at both heterotopic and orthotopic sites. In this review, we mainly concentrate on BMP structure, function, molecular signaling and potential medical application.
Xiao
Yong-Tao
YT
College of Life Sciences, Zhejiang University, 310058, China.
Xiang
Li-Xin
LX
Shao
Jian-Zhong
JZ
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism; D049109:Cell Proliferation; D019281:Dimerization; D006031:Glycosylation; D006801:Humans; D008954:Models, Biological; D008968:Molecular Conformation; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta