title: Cholesterol-lowering ability of a phytostanol softgel supplement in adults with mild to moderate hypercholesterolemia.
abstract: Plant sterols, incorporated into spreads and other food sources, have been shown to lower serum cholesterol concentrations. The effect of phytostanol supplementation in softgel form has not been assessed. Our objective was to examine the effects of sitostanol as sitostanol ester in softgel form on serum lipid concentrations in hypercholesterolemic individuals. Thirty hypercholesterolemic adults were supplemented with 1.6 g of free phytostanol equivalents as phytostanol ester (2.7 g stanol esters) or placebo per day for 28 d in a randomized, double-blind, parallel study design. Phytostanol supplementation resulted in a significant decrease in total cholesterol (TC) (-8%) and LDL-cholesterol (-9%). There were no alterations in concentrations of HDL-cholesterol or TG. Nor were the ratios of LDL/HDL or TC/HDL altered significantly. Thus, use of phytostanol ester softgel supplements improved serum total and LDL-cholesterol concentrations in hypercholesterolemic individuals.
authors: Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 5B6, Canada.
authors: Derek
authors: D
authors: Woodgate
authors: Christina H M
authors: CH
authors: Chan
authors: Julie A
authors: JA
authors: Conquer
mesh_terms: D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D008078:Cholesterol, LDL / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012855:Sitosterols / Q000627:therapeutic use*
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D012855:Sitosterols; C407042:plant stanol ester
references: Clin Chem. 1972 Jun;18(6):499-502
references: 4337382
references: Am J Clin Nutr. 2002 Dec;76(6):1272-8
references: 12450893
references: Am J Clin Nutr. 2000 Apr;71(4):908-13
references: 10731496
references: N Engl J Med. 1995 Nov 16;333(20):1308-12
references: 7566021
references: Br J Nutr. 2002 Nov;88(5):479-88
references: 12425728
references: Monogr Atheroscler. 1981;10:1-219
references: 7231433
references: Eur J Nutr. 2003 Jun;42(3):154-64
references: 12811473
references: J Lipid Res. 2003 Sep;44(9):1713-9
references: 12730296
references: Eur J Clin Nutr. 2004 Mar;58(3):503-9
references: 14985690
references: Diabetologia. 1994 Aug;37(8):773-80
references: 7988779
references: J Nutr. 2004 Jun;134(6):1395-9
references: 15173402
references: Eur J Clin Nutr. 1998 May;52(5):334-43
references: 9630383
references: Atherosclerosis. 1999 Aug;145(2):279-85
references: 10488954
references: J Lipid Res. 1995 Aug;36(8):1807-12
references: 7595101
references: BMJ. 2000 Mar 25;320(7238):861-4
references: 10731187
references: Atherosclerosis. 1994 Feb;105(2):217-26
references: 8003098
references: Lipids. 2003 Apr;38(4):367-75
references: 12848281
references: J Nutr. 2003 Oct;133(10):3103-9
references: 14519792
references: Eur J Clin Nutr. 2000 Sep;54(9):715-25
references: 11002384
references: Am J Cardiol. 2002 Oct 1;90(7):737-40
references: 12356387
references: Eur J Clin Pharmacol. 1991;40 Suppl 1:S59-63
references: 2044646
references: Am J Cardiol. 2000 Jul 1;86(1):46-52
references: 10867091
references: J Lipid Res. 2000 May;41(5):697-705
references: 10787430
references: Am J Cardiol. 2001 Nov 15;88(10):1157-62
references: 11703963
references: Am J Clin Nutr. 2002 Jan;75(1):79-86
references: 11756063
references: J Nutr. 1999 Dec;129(12):2109-12
references: 10573535
references: Eur J Clin Nutr. 2001 Dec;55(12):1084-90
references: 11781675
references: J Pediatr. 1993 Feb;122(2):292-6
references: 8429449