title: [Experience in postoperative sedation with dexmedetomidine for mandibular osteotomy].
abstract: BACKGROUND
  Dexmedetomidine may be suitable for postoperative sedation of patients with mandibular osteotomy.
  
  
  METHODS
  Twenty patients were sedated with dexmedetomidine (group D) employing loading infusion at 1.0 microg x kg(-) x hr(-1) and then continuous infusion at 0.7 mg x kg(-1) x hr(-1). Other twenty patients were sedated with midazolam 0.1 mg x kg(-1) (group C). Ramsay score was recorded at 3 hours and 12 hours after infusing sedative drugs. Then, we questioned patients, nurses and doctors.
  
  
  RESULTS
  Ramsay score in the group D was higher than that in the group C (P < 0.01). Hypotension and respiratory depression did not occur. But bradycardia occurred in two cases. By adding propofol, group D showed more effective sedation.
  
  
  CONCLUSIONS
  This study shows that sedation with dexmedetomidine is more suitable than that with midazolam.
authors: Department of Anesthesiology, University of Tokai School of Medicine, Isehara 259-1193.
authors: Miho
authors: M
authors: Maeda
authors: Haruo
authors: H
authors: Fukuyama
authors: Satoko
authors: S
authors: Ando
authors: Toshiyasu
authors: T
authors: Suzuki
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D016292:Procedural Sedation; D020927:Dexmedetomidine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008334:Mandible / Q000601:surgery*; D008874:Midazolam; D010027:Osteotomy; D011182:Postoperative Care; D015742:Propofol / Q000008:administration & dosage
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D008874:Midazolam; D015742:Propofol