title: Photodynamic therapy for lung cancers based on novel photodynamic diagnosis using talaporfin sodium (NPe6) and autofluorescence bronchoscopy.
abstract: BACKGROUND
  We had previously developed the possibility of use of a photodynamic diagnosis (PDD) system using a tumor-selective photosensitizer and laser irradiation for the early detection and photodynamic therapy (PDT) for centrally located early lung cancers. Recently, we established the autofluorescence diagnosis system integrated into a videoendoscope (SAFE-3000) as a very useful technique for the early diagnosis of lung cancer.
  
  
  METHODS
  Twenty-nine patients (38 lesions) with centrally located early lung cancer received PDD and PDT using the second-generation photosensitizer, talaporfin sodium (NPe6). Just before the PDT, we defined the tumor margin accurately using the novel PDD system SAFE-3000 with NPe6 and a diode laser (408nm).
  
  
  RESULTS
  Red fluorescence emitted from the tumor by excitation of the photosensitizer by the diode laser (408nm) from SAFE-3000 allowed accurate determination of the tumor margin just before the PDT. The complete remission (CR) rate following NPe6-PDT in the cases with early lung cancer was 92.1% (35/38 lesions). We also confirmed the loss of red fluorescence from the tumors immediately after the PDT using SAFE-3000. We confirmed that all the NPe6 in the tumor had been excited and photobleached by the laser irradiation (664nm) and that no additional laser irradiation was needed for curative treatment.
  
  
  CONCLUSIONS
  This novel PDD system using SAFE-3000 and NPe6 improved the quality and efficacy of PDT and avoided misjudgement of the dose of the photosensitizer or laser irradiation in PDT. PDT using NPe6 will become a standard option of treatments for centrally located early lung cancer.
authors: Department of Thoracic Surgery, Tokyo Medical University Hospital, Tokyo 160-0023, Japan. jusuda@tokyo-med.ac.jp
authors: Jitsuo
authors: J
authors: Usuda
authors: Hidemitsu
authors: H
authors: Tsutsui
authors: Hidetoshi
authors: H
authors: Honda
authors: Shuji
authors: S
authors: Ichinose
authors: Taichirou
authors: T
authors: Ishizumi
authors: Takeshi
authors: T
authors: Hirata
authors: Tatsuya
authors: T
authors: Inoue
authors: Keishi
authors: K
authors: Ohtani
authors: Sachio
authors: S
authors: Maehara
authors: Kentarou
authors: K
authors: Imai
authors: Yoshihiko
authors: Y
authors: Tsunoda
authors: Mitsuhiro
authors: M
authors: Kubota
authors: Norihiko
authors: N
authors: Ikeda
authors: Kinya
authors: K
authors: Furukawa
authors: Tetsuya
authors: T
authors: Okunaka
authors: Harubumi
authors: H
authors: Kato
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001999:Bronchoscopy; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects; D011166:Porphyrins / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D011166:Porphyrins; C053434:Talaporfin