Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structure-related phenotypes.
OBJECTIVE
We performed a systematic review of the literature by means of a meta-analysis to evaluate the influence of the aldosterone synthase gene (CYP11B2) C-344T polymorphism on left ventricular mass (LVM) and related phenotypes.


METHODS
From 485 reports, we included 14 studies about the association between the C-344T variant and left ventricular mass and left ventricular structure-related phenotypes, from which information about number of subjects in each category, outcomes data and genotyping performed with a validated molecular method could be extracted. Fixed and random effect models were used to pool data from individual studies, and the results in the abstract show the extreme genotype comparison, homozygous TT vs homozygous CC.


RESULTS
From a total of 2157 subjects, we found no significant association between LVM and the C-344T variant (D: 0.049, 95% CI: 0.091 to 0.179, p = 0.462). Similarly, no significant association was found for interventricular septal-wall thickness (D: 0.027, 95% CI: -0.090 to 0.143, p = 0.654, n: 2105). However, homozygous TT hypertensive subjects had increased LVM (D: 0.251, 95% CI: 0.020 to 0.481, p = 0.04, n: 332). Lastly, in 10 homogeneous studies posterior wall thickness (PWT) was lower in homozygous CC individuals (D: 0.142, 95% CI: 0.016 to 0.268, p = 0.028, n = 1994).


CONCLUSIONS
Independently of hypertension, homozygous individuals for the -344T allele may have 2.4% higher PWT compared to homozygous subjects for the C-344 allele. Besides, homozygous hypertensive TT subjects show a 6.9% increase in LVM compared to CC homozygous subjects.
Sookoian
S
S
Departamento de Genética y Biología Molecular de Enfermedades Complejas, Instituto de Investigaciones Medicas, A Lanari, Universidad de Buenos Aires, CONICET, Ciudad Autónoma de Buenos Aires, Argentina.
Gianotti
T F
TF
Pirola
C J
CJ
D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D003971:Diastole; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006352:Heart Ventricles / Q000033:anatomy & histology / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000235:genetics; D017379:Hypertrophy, Left Ventricular / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D013599:Systole
D019405:Cytochrome P-450 CYP11B2