Soft shell resins for solid-phase peptide synthesis.
Soft shell (SS) resins with a lightly or noncross-linked shell layer were prepared by reducing the amount of cross-linking agent, divinylbenzene (DVB), during seed suspension polymerization from polystyrene (PS) resin. These SS resins have a lower swelling volume than that produced by normal cross-linking. Despite its lower swelling, however, SS (10-00) resin, which consists of the 1% DVB-cross-linked core and the noncross-linked surface layer, showed higher efficiency in peptide synthesis compared with 1% DVB-PS resin and other SS resins.
Lee
Tae-Kyung
TK
School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
Choi
Jeong-Hyun
JH
Ryoo
Sun-Jong
SJ
Lee
Yoon-Sik
YS
D002851:Chromatography, High Pressure Liquid; D018613:Microscopy, Confocal; D010446:Peptide Fragments / Q000138:chemical synthesis; D010455:Peptides / Q000138:chemical synthesis*; D011137:Polystyrenes / Q000737:chemistry; D012117:Resins, Synthetic / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
D010446:Peptide Fragments; D010455:Peptides; D011137:Polystyrenes; D012117:Resins, Synthetic; D014753:Vinyl Compounds; C004985:divinyl benzene