Large sequence polymorphisms classify Mycobacterium tuberculosis strains with ancestral spoligotyping patterns.
Genomic deletion analysis revealed that strains of Mycobacterium tuberculosis exhibiting spoligotyping patterns with almost all spacers present belong either to a strain lineage that includes the W-Beijing strain family or to the ancestral strain lineage of M. tuberculosis.
Flores
Laura
L
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, USA.
Van
Tran
T
Narayanan
Sujatha
S
DeRiemer
Kathryn
K
Kato-Maeda
Midori
M
Gagneux
Sebastien
S
D017353:Gene Deletion; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid
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