title: Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma.
abstract: BACKGROUND
  The aim of this study was to evaluate immunohistochemical markers in pancreatic cancer and to determine the association of their expression with clinicopathological features and prognosis.
  
  
  METHODS
  Thirty pancreatic adenocarcinoma patients were followed-up for an average period of 5 years. FAS, bcl-2, p53 and Ki-67 expression were detected immunohistochemically to determine their prognostic value.
  
  
  RESULTS
  FAS was statistically associated with p53 (p = 0.002), Ki-67 (p = 0.003), higher histological grade (p = 0.001 and recurrence and overall survival (p = 0.001).
  
  
  CONCLUSIONS
  The newly found overexpression of FAS in highly aggressive pancreatic carcinomas may help us stratify patients into different prognostic groups and indicate new therapeutic strategies.
authors: Department of Experimental Pathology and Medicine, University of Rome "La Sapienza", Rome, Italy. pieroluigi.alo@uniroma1.it
authors: Piero L
authors: PL
authors: Alo
authors: Mostafa
authors: M
authors: Amini
authors: Francesca
authors: F
authors: Piro
authors: Laura
authors: L
authors: Pizzuti
authors: Valeria
authors: V
authors: Sebastiani
authors: Claudio
authors: C
authors: Botti
authors: Riccardo
authors: R
authors: Murari
authors: Giancarlo
authors: G
authors: Zotti
authors: Ugo
authors: U
authors: Di Tondo
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D064429:Fatty Acid Synthases / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D010190:Pancreatic Neoplasms / Q000201:enzymology* / Q000473:pathology
chemical_list: D064429:Fatty Acid Synthases