Primary hepatic malignant fibrous histiocytoma: a case report and review of the literature.
Primary malignant fibrous histiocytoma (MFH) of the liver remains extremely rare with only several cases having been reported in literature. We report a case of hepatic MFH in a 53-year-old man who presented with upper abdominal pain, and weight loss for one month. Ultrasound and computed tomography (CT) scan showed a large mass with fine tumor vessels over the left lobe of the liver. Histopathological findings indicated a mesenchymal tumor consisting of spindle cells in storiform pattern intermingled with histiocyte-like cells and giant cells. Immunohistochemically, most tumor cells expressed vimentin, alpha-1 anti-chymotrypsin, alpha-1 antitrypsin and CD68. Morphological and immunohistochemical findings support that the tumor should be classified as a primary malignant fibrous histiocytoma. The literatures is briefly reviewed.
Ye
M-F
MF
Cancer Institute, The Second Affiliated Hospital, School of Medicine, Zhejiang University, China.
Zheng
S
S
Xu
J-H
JH
Chen
L-R
LR
D015703:Antigens, CD / Q000096:biosynthesis; D015214:Antigens, Differentiation, Myelomonocytic / Q000096:biosynthesis; D002918:Chymotrypsin / Q000096:biosynthesis; D017809:Fatal Outcome; D006505:Hepatitis / Q000150:complications; D051677:Histiocytoma, Malignant Fibrous / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000096:biosynthesis; D000515:alpha 1-Antitrypsin / Q000096:biosynthesis; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D002918:Chymotrypsin; D014746:Vimentin; D000515:alpha 1-Antitrypsin; C067980:CD68 antigen, human; D000097382:CD68 Molecule