[The clinical features and outcomes of immunoglobulin light-chain amyloidosis with heart involvement].
OBJECTIVE
To analyze the clinical features and outcomes of patients with immunoglobulin light-chain amyloidosis (AL) who had heart involvement.


METHODS
Clinical features and outcomes of AL amyloidosis patients with heart involvement in the past 7 years in our hospital were retrospectively analyzed.


RESULTS
Cardiac involvement was seen in 36 out of the 60 AL patients (60%). The clinical manifestations of cardiac amyloidosis included heart failure (50%), low QRS voltage (47.2%) and pseudomyocardial infarction (33.3%) in electrocardiography, as well as thickening of ventricular wall (63.9%), echo of granular sparkling texture (11.1%), atria dilation (33.3%) and diastolic dysfunction (30.6%) in echocardiography. The prognosis was poor, with a median survival time of 13.9 months.


CONCLUSIONS
Patients of AL amyloidosis with cardiac involvement are not rare. Thickening of ventricular wall and diastolic dysfunction are the most common characteristics. Special attention should be paid to this disease.
Meng
Lei
L
Department of Cardiology, Peking University First Hospital, Beijing 100034, China.
Ding
Wen-Hui
WH
Shi
Li-Bin
LB
Gong
Yan-Jun
YJ
Liu
Zhao-Ping
ZP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000175:diagnosis* / Q000473:pathology*; D009202:Cardiomyopathies / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
D007147:Immunoglobulin Light Chains