Rational design of vaccines against tuberculosis directed by basic immunology.
Tuberculosis represents a serious problem for public health worldwide, and effective vaccines are urgently required. This represents a significant challenge as the causative bacterial agent, Mycobacterium tuberculosis, has developed strategies to persist in infected hosts despite the presence of potent T-cell-mediated immune responses. New advances in basic immunology are giving us improved understanding of what constitutes a protective immune response and ways this response is manipulated by the bacillus. Such insights should inform us how to design more effective vaccination strategies against intracellular pathogens.
Reece
Stephen T
ST
Max Planck Institute for Infection Biology, Charitéplatz 1, D-10117 Berlin, Germany.
Kaufmann
Stefan H E
SH
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000276:immunology* / Q000627:therapeutic use; D014611:Vaccination / Q000379:methods; D022223:Vaccines, Subunit / Q000276:immunology
D000942:Antigens, Bacterial; D032581:Tuberculosis Vaccines; D022223:Vaccines, Subunit