title: Copper-catalyzed amidation of sp3 C-H bonds adjacent to a nitrogen atom.
abstract: We have developed a novel copper-catalyzed amidation of unactivated sp(3) C-H bonds adjacent to a nitrogen atom by using an inexpensive catalyst-oxidant (CuBr/(t)BuOOH) system under mild conditions. The dephenylation was first found for N-benzylaniline, and the new class of products provide diverse structures for pharmaceuticals and combinatorial chemistry.
authors: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
authors: Yongming
authors: Y
authors: Zhang
authors: Hua
authors: H
authors: Fu
authors: Yuyang
authors: Y
authors: Jiang
authors: Yufen
authors: Y
authors: Zhao
mesh_terms: D000586:Amination; D000814:Aniline Compounds / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D000814:Aniline Compounds; D002244:Carbon; D003300:Copper; D006859:Hydrogen; D009584:Nitrogen