The role of alpha-adrenoreceptors in the treatment of urological diseases.
One of the most important clinical pharmacological invention in the last decades the role of adrenoreceptors in urological disease. The disorders of emptying the bladder are associated to the urology. Plant extracts efficacy is low, indicated only in mild symptoms, surgery has to be performed in advanced cases. Recognise, discovering the role of adrenoreceptors in the prostate, bladder neck has changed the treatment of benign prostatic hyperplasia. Relieving the muscle tension leads to a better urinary flow, decreased residual urine and less complaints. Combination with 5alpha-reductase inhibitor a better results can be achieved. The inflammation in prostate is a frequent disease of all age of males. Spasm of the bladder neck maintains the complaints additional alpha-blocker treatment combined with antibiotics, anti-inflammatory drugs are the best choice to cure the patients. Alpha-adrenergic receptor can be found in the lower part of ureter as well. To promote the spontaneous expulsion of lower ureter stones, or fragments after ESWL (extracorporal shock wave lithotripsy) the alpha-blockers are highly recommended.
Romics
Imre
I
Department of Urology, Semmelweis University, Ulloi street 78/B., Budapest H-1082, Hungary. romimre@urol.sote.hu
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000328:Adult; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000188:drug therapy; D011472:Prostatitis / Q000188:drug therapy; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D052878:Urolithiasis / Q000188:drug therapy; D014570:Urologic Diseases / Q000188:drug therapy*
D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha