title: Chronic valproic acid intoxication: reversal by naloxone.
abstract: A 76-year-old woman being treated with sodium valproate for bipolar depression presented with a 4 day history of acute confusion and tremulousness. She had apnoeic episodes, reduced conscious level and generalised myoclonic movements. Her plasma valproate concentration was 848 micromol/l (normal 300-600 micromol/l). Administration of naloxone 0.8 mg led to rapid clinical improvement. Naloxone may be useful in reversing the features of chronic valproate toxicity.
authors: Scottish Poisons Information Bureau, Royal Infirmary Edinburgh, 51 Little France Crescent, Edinburgh, UK. ruben.thanacoody@luht.scot.nhs.uk
authors: H K R
authors: HK
authors: Thanacoody
mesh_terms: D000368:Aged; D018692:Antimanic Agents / Q000506:poisoning*; D001714:Bipolar Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D009270:Naloxone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy*; D014635:Valproic Acid / Q000506:poisoning*
chemical_list: D018692:Antimanic Agents; D009292:Narcotic Antagonists; D009270:Naloxone; D014635:Valproic Acid
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