Long-term persistence of antibodies after one or two doses of MMR-vaccine.
Outbreaks of measles, mumps and rubella have occurred recently despite long-standing mass immunization with MMR. Antibody titres for measles, mumps and rubella of 160 students (17-23 years) with proof of at least one MMR-vaccine were studied according to the number of MMR-vaccines received. The proportion of subjects with positive antibody titres was significantly higher in those who received two vaccines against measles (77.1% versus 58.7%, p=0.05), mumps (67.5% versus 55.6%, p=0.009) and rubella (99.2% versus 71.4%, p=0.008). Comparable significant trends were seen for GMTs for measles and mumps. A similar non-significant trend was noted for rubella.
Vandermeulen
Corinne
C
Department of Youth Health Care, K.U. Leuven, Kapucijnenvoer 35, Block D, Box 7001, 3000 Leuven, Belgium. corinne.vandermeulen@med.kuleuven.be
Mathieu
Roelants
R
Geert
Leroux-Roels
LR
Pierre
Van Damme
VD
Karel
Hoppenbrouwers
H
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D013997:Time Factors
D000914:Antibodies, Viral; D022542:Measles-Mumps-Rubella Vaccine