ER-mitochondria communication. How privileged?
Mitochondria have a low affinity for Ca(2+), but they take up these ions during normal cell activity because they are in close proximity to the sites of calcium entry into the cell and of internal Ca(2+) release. This gives mitochondria privileged access to cytoplasmic Ca(2+) without requiring a direct communication with the endoplasmic reticulum.
Franzini-Armstrong
Clara
C
Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. armstroc@mail.med.upenn.edu
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D051379:Mice; D008931:Mitochondria, Muscle / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000502:physiology
D002118:Calcium