[Gene mapping for autosomal dominant nonsyndromic hearing loss DFNA11].
OBJECTIVE
To map the gene locus in a Chinese pedigree with autosomal dominant nonsyndromic hearing loss.


METHODS
A genome wide screening was performed with 394 microsatellite markers distributed with an average spacing of 10 cM (ABI Prism Linkage Mapping Set 2, Applied Biosystems, Foster City, CA, U.S.A.).


RESULTS
Affected family members showed a bilateral, symmetrical, progressive neurosensory deafness. Significant linkage was found to marker D1 S937 (maximum two point LOD score of 5. 71 at theta = 0.05) on chromosome 11q. The position of the novel deafness locus, DFNA11, was delimited by analysis of the recombinant haplotypes (D11S165-D11S1874). This analysis placed DFNA11 between the proximal marker D11S1314 and the distal marker D11S898, which define a critical interval of 25.34 cM.


CONCLUSIONS
Mapping of the DFNA11 locus further confirms the great genetic heterogeneity underlying the autosomal dominant forms of hereditary deafness. Reports of more families with hearing impairment linked to this locus should contribute to the identification of the responsible gene, providing insights into the auditory function and the molecular pathophysiology of age related hearing loss.
Yuan
Hu
H
Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Chinese People's Liberation Army, Beifing 100853, China.
Han
Dong-yi
DY
Wang
Qiu-ju
QJ
Zong
Liang
L
Zhao
Ya-li
YL
D000328:Adult; D000368:Aged; D002874:Chromosome Mapping; D003638:Deafness / Q000151:congenital / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D000081412:Myosin VIIa; D009218:Myosins / Q000235:genetics*; D010375:Pedigree; D055815:Young Adult
C000631455:MYO7A protein, human; D000081412:Myosin VIIa; D009218:Myosins