Poly(2-hydroxyethyl methacrylate) emboli with increased haemostatic effect for correction of haemorrhage of complex origin in endovascular surgery of children.
Poly(2-hydroxyethyl methacrylate) (PHEMA) embolization particles with enhanced haemostatic properties were prepared by bulk or suspension polymerisation of 2-hydroxyethyl methacrylate (HEMA) followed by particle soaking in ethamsylate solution. The particles accelerated thrombus formation as evidenced by blood analysis of rabbits with implanted emboli. Usefulness of both spherical and cylindrical PHEMA particles with enhanced haemostatic effect was demonstrated on the embolization of arterial anastomosis, fistulas of the lower extremity and abdominal cavity, haemangioma and arteriovenous malformation of the head of several children.
Horák
Daniel
D
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, Prague 6, 162 06, Czech Republic. horak@imc.cas.cz
Galibin
Ilya E
IE
Adamyan
Arnold A
AA
Sitnikov
Alexander V
AV
Dan
Vasilii N
VN
Titova
Mariya I
MI
Shafranov
Vladimir V
VV
Isakov
Yurii F
YF
Gumargalieva
Klara Z
KZ
Vinokurova
Tatyana I
TI
D000293:Adolescent; D000818:Animals; D040761:Biomimetic Materials / Q000627:therapeutic use; D001777:Blood Coagulation / Q000502:physiology; D002339:Carotid Arteries / Q000473:pathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000627:therapeutic use; D008026:Ligation; D008297:Male; D010539:Permeability; D011102:Polyhydroxyethyl Methacrylate / Q000627:therapeutic use*; D016062:Porosity; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000628:therapy*; D011817:Rabbits; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects* / Q000379:methods
D011102:Polyhydroxyethyl Methacrylate; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
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