Listeria monocytogenes following orthotopic liver transplantation: central nervous system involvement and review of the literature.
Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals, including solid organ transplant recipients, but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy, and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous ampicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis, and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis.
Mizuno
Shugo
S
Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida College of Medicine, PO Box 100286, Gainesville, FL 32610-0286, United States.
Zendejas
Ivan-R
IR
Reed
Alan-I
AI
Kim
Robin-D
RD
Howard
Richard-J
RJ
Hemming
Alan-W
AW
Schain
Denise-C
DC
Soldevila-Pico
Consuelo
C
Firpi
Roberto-J
RJ
Fujita
Shiro
S
D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002490:Central Nervous System / Q000382:microbiology; D006801:Humans; D008089:Listeria monocytogenes; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008584:Meningitis, Listeria / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D000667:Ampicillin
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