A "reductionist" view of cardiomyopathy.
Oxidative stress due to the generation of reactive oxygen species has been implicated in many diseases. Rajasekaran et al. (2007) now make the surprising discovery that its counterpart "reductive stress," caused by an increase in reduced glutathione, contributes to cardiomyopathy triggered by protein aggregation.
Dimmeler
Stefanie
S
Department of Internal Medicine III, J.W. Goethe University, 60590 Frankfurt, Germany. dimmeler@em.uni-frankfurt.de
Zeiher
Andreas M
AM
D000818:Animals; D009202:Cardiomyopathies / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*