title: Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis.
abstract: Enzymes in the matrix metalloproteinase (MMP) family have been linked to key events in developmental biology for almost 50 years. Biochemical, cellular and in vivo analyses have established that pericellular proteolysis contributes to numerous aspects of ontogeny including ovulation, fertilization, implantation, cellular migration, tissue remodeling and repair. Surface anchoring of proteinase activity provides spatial restrictions on substrate targeting. This review will utilize membrane type 1 MMP (MT1-MMP) as an example to highlight substrate diversity in pericellular proteolysis catalyzed by a membrane anchored MMP.
authors: Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA.
authors: Maria V
authors: MV
authors: Barbolina
authors: M Sharon
authors: MS
authors: Stack
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism*; D006801:Humans; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D011509:Proteoglycans / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D011509:Proteoglycans; D053511:Matrix Metalloproteinase 14
references: J Biol Chem. 2002 Mar 1;277(9):7377-85
references: 11741954
references: J Biol Chem. 2002 Mar 22;277(12):9749-56
references: 11724803
references: J Cell Biol. 2002 Apr 29;157(3):493-507
references: 11970960
references: Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14
references: 11994741
references: Essays Biochem. 2002;38:21-36
references: 12463159
references: Curr Top Dev Biol. 2003;54:1-74
references: 12696745
references: Cancer Lett. 2003 May 8;194(1):1-11
references: 12706853
references: Cancer Res. 2003 May 1;63(9):2292-9
references: 12727852
references: Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2550-6
references: 12766056
references: Cell. 2003 Jul 11;114(1):33-45
references: 12859896
references: J Biol Chem. 2003 Oct 17;278(42):40764-70
references: 12904296
references: Blood. 2003 Nov 1;102(9):3262-9
references: 12855577
references: Exp Cell Res. 2003 Nov 15;291(1):167-75
references: 14597417
references: J Urol. 2003 Dec;170(6 Pt 1):2248-52
references: 14634390
references: J Biol Chem. 2004 Feb 6;279(6):4260-8
references: 14645246
references: Br J Cancer. 2004 Feb 9;90(3):561-5
references: 14760364
references: FASEB J. 2004 Feb;18(2):364-6
references: 14688206
references: Biochemistry. 1996 Oct 8;35(40):13056-63
references: 8855941
references: Immunol Today. 1996 Nov;17(11):532-40
references: 8961631
references: J Biol Chem. 1997 Jan 24;272(4):2446-51
references: 8999957
references: Lab Invest. 1997 May;76(5):651-60
references: 9166284
references: J Cell Biol. 1997 Dec 1;139(5):1349-60
references: 9382879
references: Cell. 1997 Nov 14;91(4):439-42
references: 9390552
references: Eur J Biochem. 1997 Dec 15;250(3):751-7
references: 9461298
references: J Biol Chem. 1998 Feb 6;273(6):3604-10
references: 9452488
references: Biochem J. 1998 Sep 1;334 ( Pt 2):345-53
references: 9716492
references: J Cell Sci. 1998 Sep;111 ( Pt 18):2789-98
references: 9718371
references: Cell. 1998 Oct 30;95(3):365-77
references: 9814707
references: J Biol Chem. 1999 May 7;274(19):13613-8
references: 10224132
references: J Biol Chem. 1999 Aug 6;274(32):22679-85
references: 10428849
references: Bioessays. 1999 Nov;21(11):940-9
references: 10517867
references: Cell. 1999 Oct 1;99(1):81-92
references: 10520996
references: Biochemistry. 1999 Oct 19;38(42):13928-36
references: 10529239
references: Proc Natl Acad Sci U S A. 1962 Jun 15;48:1014-22
references: 13902219
references: Onkologie. 2004 Dec;27(6):577-82
references: 15591720
references: J Cell Biol. 2000 Feb 7;148(3):615-24
references: 10662785
references: J Cell Biol. 2000 Feb 21;148(4):825-38
references: 10684262
references: Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4052-7
references: 10737763
references: J Biol Chem. 2000 Apr 21;275(16):12080-9
references: 10766841
references: Adv Exp Med Biol. 2000;477:217-28
references: 10849749
references: J Cell Biol. 2000 Jun 12;149(6):1309-23
references: 10851027
references: Mol Biol Cell. 2000 Jul;11(7):2387-401
references: 10888676
references: J Biol Chem. 2000 Oct 20;275(42):33008-13
references: 10930399
references: J Biol Chem. 2000 Dec 15;275(50):39497-506
references: 10991943
references: Arthritis Rheum. 2001 Feb;44(2):253-9
references: 11229454
references: Front Biosci. 2001 Mar 1;6:D417-28
references: 11229872
references: Arch Biochem Biophys. 2001 Jun 1;390(1):51-6
references: 11368514
references: J Biol Chem. 2001 May 25;276(21):18415-22
references: 11278623
references: J Cell Biol. 2001 May 28;153(5):893-904
references: 11381077
references: J Thromb Haemost. 2006 Jul;4(7):1484-6
references: 16839342
references: J Cell Sci. 2006 Sep 15;119(Pt 18):3822-32
references: 16926191
references: Cancer Res. 2006 Nov 1;66(21):10460-5
references: 17079467
references: J Biol Chem. 2006 Nov 24;281(47):35593-7
references: 17005550
references: J Biol Chem. 2006 Dec 1;281(48):36846-55
references: 17018528
references: Mol Biol Cell. 2006 Dec;17(12):5390-9
references: 17050733
references: J Biol Chem. 2006 Dec 8;281(49):37576-85
references: 17050542
references: J Biol Chem. 2007 Feb 16;282(7):4924-31
references: 17158885
references: Cancer Res. 2007 Mar 1;67(5):2030-9
references: 17332331
references: Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1615-21
references: 17389491
references: J Mol Biol. 2007 May 11;368(4):1101-13
references: 17379243
references: Am J Pathol. 2007 Jun;170(6):2100-11
references: 17525276
references: Biochem J. 2007 Oct 15;407(2):171-7
references: 17650075
references: J Biol Chem. 2002 May 17;277(20):17511-9
references: 11891230
references: J Biol Chem. 2002 Jul 19;277(29):26340-50
references: 12004057
references: Blood. 2002 Aug 15;100(4):1160-7
references: 12149192
references: J Biol Chem. 2002 Oct 11;277(41):39005-14
references: 12145314
references: Cancer Res. 2004 Feb 1;64(3):876-82
references: 14871815
references: J Biol Chem. 2004 Feb 27;279(9):8278-89
references: 14670950
references: J Biol Chem. 2004 Feb 27;279(9):7721-33
references: 14672946
references: Clin Exp Metastasis. 2004;21(1):75-8
references: 15065605
references: Proc Natl Acad Sci U S A. 2004 May 4;101(18):6917-22
references: 15118097
references: J Cell Physiol. 2004 Jul;200(1):2-10
references: 15137052
references: Anticancer Res. 2004 May-Jun;24(3b):2027-31
references: 15274395
references: Biochem J. 2004 Aug 15;382(Pt 1):363-73
references: 15130087
references: Endocrinology. 2004 Sep;145(9):4192-203
references: 15142990
references: Cancer Res. 2004 Oct 1;64(19):7058-64
references: 15466200
references: J Biol Chem. 2004 Oct 8;279(41):43336-44
references: 15292230
references: Cell Biol Int Rep. 1985 Dec;9(12):1097-107
references: 3000628
references: J Biol Chem. 1993 Jul 5;268(19):14033-9
references: 8314771
references: Nature. 1994 Jul 7;370(6484):61-5
references: 8015608
references: J Biol Chem. 1995 Mar 10;270(10):5331-8
references: 7890645
references: FEBS Lett. 1996 May 6;385(3):238-40
references: 8647259
references: FEBS Lett. 1996 Sep 9;393(1):101-4
references: 8804434
references: J Cell Sci. 2005 Jan 1;118(Pt 1):147-56
references: 15601659
references: EMBO J. 2005 Feb 23;24(4):742-52
references: 15692570
references: Curr Pharm Des. 2005;11(7):881-91
references: 15777241
references: Biochimie. 2005 Mar-Apr;87(3-4):361-8
references: 15781323
references: Neoplasia. 2005 Apr;7(4):380-9
references: 15967115
references: J Biol Chem. 2005 Jul 1;280(26):25079-86
references: 15878869
references: Cancer Metastasis Rev. 2005 Jun;24(2):195-222
references: 15986132
references: Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9182-7
references: 15958533
references: J Biol Chem. 2005 Jul 15;280(28):26160-8
references: 15901740
references: J Biol Chem. 2006 Mar 10;281(10):6826-40
references: 16407177
references: Exp Oncol. 2006 Mar;28(1):83-5
references: 16614715
references: Cell. 2006 May 5;125(3):577-91
references: 16678100
references: Skin Pharmacol Physiol. 2006;19(2):65-70
references: 16685144
references: Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9017-22
references: 16754882
references: Pathol Int. 2006 Jul;56(7):359-67
references: 16792544
references: J Biol Chem. 2002 Nov 15;277(46):44061-7
references: 12226090
references: Biol Chem. 2002 Jul-Aug;383(7-8):1095-105
references: 12437092
references: FEBS Lett. 2002 Dec 4;532(1-2):127-30
references: 12459476
references: Nature. 2005 Jul 14;436(7048):193-200
references: 16015319
references: Cancer. 2005 Aug 15;104(4):740-6
references: 15991243
references: Mol Cancer Ther. 2005 Aug;4(8):1157-66
references: 16093431
references: J Cell Sci. 2005 Nov 1;118(Pt 21):4975-84
references: 16219679
references: Am J Physiol Renal Physiol. 2006 Jan;290(1):F43-51
references: 16077081
references: J Biol Chem. 2005 Dec 23;280(51):42237-41
references: 16251193
references: J Neurosci. 2006 Feb 22;26(8):2300-12
references: 16495457
references: J Biol Chem. 2001 Jul 6;276(27):24833-42
references: 11331272
references: Cancer Res. 2001 Sep 1;61(17):6322-7
references: 11522618
references: EMBO J. 2001 Sep 3;20(17):4782-93
references: 11532942
references: J Biol Chem. 2001 Nov 23;276(47):43503-8
references: 11571304
references: J Exp Med. 2002 Feb 4;195(3):295-308
references: 11828004