Prolactin as a factor for increased platelet aggregation.
Administration of antipsychotics appears to be related to increased risk of venous thromboembolism and cerebrovascular side effects. The biological mechanism responsible for this possible adverse drug reaction is unknown, but there is a growing number of elucidating hypotheses. Treatment with antipsychotics is associated with elevation of prolactin level. Prolactin has recently been recognized as potent platelet aggregation co-activator, and have therefore been postulated as an additional risk factor for both arterial and venous thrombosis. We briefly review the arguments for the role of hyperprolactinemia in pathogenesis of platelet aggregation.
Urban
Ales
A
Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic. a.urban@centrum.cz
Masopust
Jirí
J
Malý
Radovan
R
Hosák
Ladislav
L
Kalnická
Dita
D
D000328:Adult; D001777:Blood Coagulation / Q000502:physiology; D005260:Female; D006801:Humans; D010974:Platelet Aggregation / Q000502:physiology*; D011388:Prolactin / Q000502:physiology*; D011619:Psychotropic Drugs / Q000009:adverse effects; D013927:Thrombosis / Q000209:etiology
D011619:Psychotropic Drugs; D011388:Prolactin