Reproducibility of activations in Broca area with two language tasks: a functional MR imaging study.
OBJECTIVE
Functional MR imaging (fMRI) is rapidly evolving and claims to complement or even substitute intraoperative mapping (IOM) of language functions. However, little is known about the reproducibility of imaging data in the language domain. The aim of our study was to assess the reproducibility of activations for 2 widely used paradigms: naming and word generation. Individual analysis was focused on the Broca area and the left insula.


METHODS
We examined 13 healthy right-handed subjects in 3 sessions with fMRI. Two conditions were assessed: overt naming and overt naming plus noun generation. The same stimuli were used in all of the sessions. A random-effects analysis was performed to analyze whole-brain activation on a group level. For the regions of interest, the number of voxels classified as active were counted for each subject, and individual reproducibility coefficients were calculated over sessions.


RESULTS
For the naming condition, the random-effects analysis did not reveal significant activations in the specified regions; small individual activations were not reproducible. For the combined task, all of the subjects showed activations in the Broca area that were more extensive and reproducible than in the naming task. Activations in the insula were only poorly reproducible.


CONCLUSIONS
Naming is an approved task in IOM but does not identify the Broca area with fMRI in a reproducible way. Priming may have affected our results, but the use of a combined task, in which naming is paired with noun generation, improves the reproducibility of activations and is also suitable for IOM.
Rau
S
S
Department of Physical Medicine and Rehabilitation, University Clinics of Munich, Munich, Germany.
Fesl
G
G
Bruhns
P
P
Havel
P
P
Braun
B
B
Tonn
J-C
JC
Ilmberger
J
J
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011932:Reading; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013647:Task Performance and Analysis
Cereb Cortex. 1994 Jan-Feb;4(1):8-26
8180494
Brain Res Cogn Brain Res. 2000 Jan;9(1):19-33
10666553
Eur J Neurosci. 2005 Feb;21(4):1101-6
15787715
Neurosurgery. 1997 Dec;41(6):1253-60; discussion 1260-2
9402576
Brain. 2000 Mar;123 Pt 3:620-40
10686183
Magn Reson Med. 1990 Apr;14(1):68-78
2161986
Brain. 1998 Jun;121 ( Pt 6):1013-52
9648540
Neuropsychologia. 1971 Mar;9(1):97-113
5146491
Cereb Cortex. 2000 Dec;10(12):1176-84
11073867
Neuroimage. 2004 May;22(1):42-56
15109996
Cereb Cortex. 2003 Apr;13(4):381-91
12631567
J Neurol Neurosurg Psychiatry. 2005 Jun;76(6):845-51
15897509
J Neurosci. 1991 Aug;11(8):2281-7
1869914
J Neurosurg. 2002 Jul;97(1):33-8
12134930
Neuroimage. 1999 Jul;10(1):15-35
10385578
Neuroimage. 2002 Jan;15(1):273-89
11771995
Neuropsychology. 2005 Jul;19(4):484-93
16060823
AJNR Am J Neuroradiol. 2001 Oct;22(9):1711-8
11673166
Biochim Biophys Acta. 1982 Feb 2;714(2):265-70
6275909
Magn Reson Imaging. 1998;16(2):105-13
9508267
J Neurosci. 1995 Sep;15(9):5870-8
7666172
Cogn Affect Behav Neurosci. 2004 Mar;4(1):43-57
15259888
Neurology. 2003 Mar 25;60(6):969-75
12654961
Neuroimage. 2006 Aug 1;32(1):129-37
16697224
Brain Lang. 2002 Mar;80(3):421-37
11896650
Neuroreport. 2000 Feb 28;11(3):617-22
10718324
J Comput Assist Tomogr. 1995 Sep-Oct;19(5):788-96
7560327
Neuron. 1999 Jul;23(3):513-22
10433263
Magn Reson Med. 1990 Oct;16(1):9-18
2255240
Brain Lang. 2001 Feb;76(2):111-8
11254252
J Cogn Neurosci. 1993 Fall;5(4):467-79
23964919