Endocannabinoids and the haematological system.
Endocannabinoids are blood borne and may also be secreted by the endothelium. Accordingly, there has been interest in the interactions between (endo)cannabinoids and blood cells. There is certainly evidence that (endo)cannabinoids may promote platelet activation, indicating that they may be thrombogenic. Platelets are involved both in the metabolism and release of endocannabinoids, and so it is possible that their circulating levels may be regulated by platelets. This process is altered in disease states such that platelet-derived endocannabinoids contribute towards hypotension in cardiovascular shock. Not only may endocannabinoids regulate platelet function and possibly lead to thrombogenesis, but they may also influence haematopoiesis. Given these emerging roles, the aim of this review is to examine the interactions between cannabinoids and blood.
Randall
M D
MD
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, UK. michael.randall@nottingham.ac.uk
D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism / Q000503:physiopathology; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology; D063388:Endocannabinoids; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D015539:Platelet Activation / Q000187:drug effects
D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids
FEBS Lett. 2000 Apr 7;471(1):12-6
10760504
Br J Pharmacol. 2004 May;142(1):20-6
15131000
Circulation. 2001 Jun 12;103(23):2805-9
11401936
Arch Biochem Biophys. 2001 Sep 15;393(2):321-8
11556820
FASEB J. 2001 Oct;15(12):2171-8
11641243
Blood. 2002 Apr 15;99(8):2786-93
11929767
Blood. 2002 Dec 1;100(12):4040-8
12393387
Blood. 2004 Jul 15;104(2):526-34
15039279
Br J Pharmacol. 2004 Aug;142(8):1354-60
15277315
Anesth Analg. 2004 Oct;99(4):1127-30, table of contents
15385362
N Engl J Med. 1974 Jun 11;291(2):65-7
4599385
Int J Clin Pharmacol Res. 1985;5(4):243-6
2997048
J Biol Chem. 1997 Feb 7;272(6):3315-23
9013571
Blood. 1997 Aug 15;90(4):1448-57
9269762
Nature. 1997 Dec 4;390(6659):518-21
9394002
Mol Pharmacol. 1998 Jul;54(1):180-8
9658204
FASEB J. 1998 Aug;12(11):1035-44
9707176
Eur J Pharmacol. 1998 Nov 27;362(1):R1-3
9865537
FEBS Lett. 1999 Mar 26;447(2-3):277-82
10214961
Eur J Biochem. 1999 Aug;264(1):258-67
10447696
Thromb Haemost. 2004 Nov;92(5):1159-61
15543349
Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1344-51
15528233
Nature. 2005 Apr 7;434(7034):782-6
15815632
J Lipid Res. 2005 Aug;46(8):1652-9
15930521
J Neuroimmunol. 2005 Sep;166(1-2):3-18
16023222
Eur J Biochem. 2001 Feb;268(3):819-25
11168423
Atherosclerosis. 2005 Sep;182(1):47-55
16115474
Cephalalgia. 2006 Mar;26(3):277-81
16472333
Clin Chem Lab Med. 2006;44(4):488-91
16599845
Am J Cardiol. 2006 Aug 15;98(4):478-84
16893701
Pharmacol Rev. 2006 Sep;58(3):389-462
16968947
Br J Pharmacol. 2007 Mar;150(5):641-51
17245358
Thromb Haemost. 2003 Feb;89(2):340-7
12574815
Eur J Biochem. 2003 Sep;270(17):3498-506
12919314
Br J Pharmacol. 2004 Mar;141(5):775-85
14757702