Dipyrone improves small airway function in asthmatic patients with moderate obstruction.
BACKGROUND
Dipyrone is an analgesic and antipyretic agent with a distinctive spasmolytic effect on smooth muscles. We recently showed that dipyrone significantly relaxed precontracted tracheal smooth muscle in guinea pig.


OBJECTIVE
To investigate whether this in vitro observation could be observed in vivo in the respiratory function parameters of asthma patients.


METHODS
Twenty-two patients, aged 18 to 75 years and diagnosed with asthma according to the American Thoracic Society criteria were enrolled at the time they had any indication for dipyrone use. Pulmonary function tests were performed before and 30, 60, 90, and 120 minutes after oral intake of 1 g of dipyrone. The tests were repeated without dipyrone intake in a situation of spontaneous recovery after a minimum washout period of 2 days.


RESULTS
Patients were classified according to their baseline forced expiratory volume in 1 second (FEV1) as having mild obstruction (FEV > or =80% predicted) or moderate obstruction (FEV1 60%-80% predicted). Significant improvement with dipyrone was seen in FEV1 and peak expiratory flow rates at 25%, 50% and 75%) of forced vital capacity and in maximum midexpiratory flow rate only in patients with moderate asthma. No significant change was observed on the spontaneous recovery day except in FEV1.


CONCLUSIONS
Dipyrone had a significant effect leading to an improved small airway function in asthmatic patients with moderate airway obstruction, confirming our recent in vitro findings.
Gulmez
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SE
Department of Pharmacology and Clinical Pharmacology, Ankara University Faculty of Medicine, Ankara, Turkey. egulmez@health.sdu.dk
Celik
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G
Misirligil
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Z
Tulunay
F C
FC
D000328:Adult; D000402:Airway Obstruction / Q000188:drug therapy / Q000209:etiology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D004177:Dipyrone / Q000494:pharmacology*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate / Q000187:drug effects*; D013147:Spirometry; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004177:Dipyrone