[Observation on effect of Wuling Capsule in treating poststroke depression].
OBJECTIVE
To evaluate the efficacy of Wuling Capsule (WLC) in treating patients with poststroke depression.


METHODS
One hundred and eight patients with poststroke depression were randomly assigned to three groups, 36 in each. All were treated with routine medicine, but to the WLC group and the FLX group, additional WLC and fluoxetine was given respectively, while to the combined group, both of the two were given. Patients' neurological and cognitive function were estimated by HAMI) scale, MMSE scale, SSS scale and Barthel index (BI) before treatment and at 4 weeks and 12 weeks after treatment.


RESULTS
HAMD score and SSS score significantly decreased (P < 0.01) while MMSE score and BI score significantly increased (P <0.05) in all the three groups, but the improvement in decrease of HAMD score and in increase of BI score in the combined group was more significant than those in the other two groups respectively (P<0.05).


CONCLUSIONS
WLC is effective in treating patients with poststroke depression and shows synergism with fluoxetine.
Xu
Bin
B
The Second Affiliated Hospital of Zhejinag TCM University, Hangzhou. xb2@hzcnc.com
Zhou
Wei-yin
WY
Zhang
Shui-jing
SJ
D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D002214:Capsules; D003863:Depression / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D020521:Stroke / Q000150:complications*; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D002214:Capsules; D004365:Drugs, Chinese Herbal; C533472:wuling; D005473:Fluoxetine