title: A hypothesis on the identification of the editing enzyme in plant organelles.
abstract: RNA editing in plant organelles is an enigmatic process leading to conversion of cytidines into uridines. Editing specificity is determined by proteins; both those known so far are pentatricopeptide repeat (PPR) proteins. The enzyme catalysing RNA editing in plants is still totally unknown. We propose that the DYW domain found in many higher plant PPR proteins is the missing catalytic domain. This hypothesis is based on two compelling observations: (i) the DYW domain contains invariant residues that match the active site of cytidine deaminases; (ii) the phylogenetic distribution of the DYW domain is strictly correlated with RNA editing.
authors: URGV, 2 Rue Gaston Crémieux, F-91057 Evry Cedex, France.
authors: Véronique
authors: V
authors: Salone
authors: Mareike
authors: M
authors: Rüdinger
authors: Monika
authors: M
authors: Polsakiewicz
authors: Beate
authors: B
authors: Hoffmann
authors: Milena
authors: M
authors: Groth-Malonek
authors: Boris
authors: B
authors: Szurek
authors: Ian
authors: I
authors: Small
authors: Volker
authors: V
authors: Knoop
authors: Claire
authors: C
authors: Lurin
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D003564:Cytidine Deaminase / Q000737:chemistry / Q000378:metabolism; D030562:Databases, Protein; D008954:Models, Biological; D008969:Molecular Sequence Data; D015388:Organelles / Q000201:enzymology* / Q000235:genetics*; D010802:Phylogeny; D010944:Plants / Q000201:enzymology* / Q000235:genetics*; D017434:Protein Structure, Tertiary; D017393:RNA Editing / Q000235:genetics*
chemical_list: D003564:Cytidine Deaminase