title: The Decapentaplegic morphogen gradient: from pattern formation to growth regulation.
abstract: Morphogens have been linked to numerous developmental processes, including organ patterning and the control of organ size. Here we review how different experimental approaches have led to an unprecedented level of molecular knowledge about the patterning role of the Drosophila melanogaster morphogen Decapentaplegic (DPP, the homologue of vertebrate bone morphogenetic protein, or BMP), the first validated secreted morphogen. In addition, we discuss how little is known about the role of the DPP morphogen in the control of organ growth and organ size. Continued efforts to elucidate the role of DPP in D. melanogaster is likely to shed light on this fundamental question in the near future.
authors: Biozentrum der Universität Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland. markus.affolter@unibas.ch
authors: Markus
authors: M
authors: Affolter
authors: Konrad
authors: K
authors: Basler
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D029721:Drosophila Proteins / Q000378:metabolism* / Q000502:physiology*; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental; D048788:Growth and Development / Q000235:genetics*; D006801:Humans; D008954:Models, Biological; D009024:Morphogenesis / Q000235:genetics; D012097:Repressor Proteins / Q000502:physiology; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C118082:brk protein, Drosophila; C064196:dpp protein, Drosophila; C094066:shn protein, Drosophila