Primary immune surveillance: some like it hot.
The thermal element of fever has been found to be beneficial in models of infectious disease. The contributions of fever-range temperatures to the efficacy of the adaptive immune response have only begun to be delineated. There is accumulating evidence that fever-range thermal stress bolsters primary immune surveillance of lymph nodes and Peyer patches by augmenting lymphocyte extravasation across specialized vessels termed high endothelial venules. Molecular mechanisms have recently come to light by which the thermal component of fever alone may promote lymphocyte trafficking, and thereby the probability of mounting a defense against microbial infection. Acquired knowledge of the molecular changes associated with thermal stress may allow for the development of novel therapies for a variety of disease processes.
Skitzki
Joseph J
JJ
Department of Immunology, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, USA.
Chen
Qing
Q
Wang
W C
WC
Evans
Sharon S
SS
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004729:Endothelium, Lymphatic / Q000276:immunology; D005334:Fever / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D006979:Hyperthermia, Induced; D007113:Immunity, Innate / Q000187:drug effects; D015850:Interleukin-6 / Q000378:metabolism; D036904:Leukocyte Rolling / Q000187:drug effects; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D010581:Peyer's Patches / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology
D018712:Analgesics, Non-Narcotic; D015850:Interleukin-6
Infect Dis Clin North Am. 1996 Mar;10(1):1-20
8698984
J Cell Physiol. 1998 Oct;177(1):137-47
9731754
Mol Immunol. 2005 May;42(7):799-809
15829268
Drugs Today (Barc). 2006 Sep;42(9):559-76
17028666
Am J Respir Crit Care Med. 1995 Jan;151(1):10-4
7812538
Methods. 2004 Jan;32(1):54-62
14624878
J Immunol. 2004 Dec 1;173(11):6753-9
15557168
J Immunol. 2003 Sep 15;171(6):3202-9
12960349
Int J Cancer. 2007 Jun 1;120(11):2418-25
17294445
J Immunol. 1998 Jan 15;160(2):961-9
9551935
Eur J Biochem. 2001 Jan;268(1):160-7
11121117
J Appl Physiol (1985). 1987 Sep;63(3):1246-52
3654470
Arch Intern Med. 2000 Feb 28;160(4):449-56
10695685
Nature. 1977 May 5;267(5606):43-5
859637
Cancer Immunol Immunother. 2003 Nov;52(11):670-9
12920482
Clin Infect Dis. 2000 Oct;31 Suppl 5:S185-9
11113022
J Leukoc Biol. 2006 Aug;80(2):227-36
16707558
Ann Intern Med. 1994 Jun 15;120(12):1037-40
7832829
Int J Hyperthermia. 2005 Dec;21(8):761-7
16338859
J Clin Invest. 2005 Jun;115(6):1616-26
15931392
Science. 1996 Apr 5;272(5258):60-6
8600538
Cancer Immunol Immunother. 2006 Mar;55(3):299-311
16044255
J Cell Biol. 2004 Oct 25;167(2):377-88
15504916
Eur J Immunol. 2004 Oct;34(10):2635-41
15368278
Int J Hyperthermia. 2002 May-Jun;18(3):253-66
12028640
Br J Cancer. 2006 Jan 30;94(2):275-80
16421594
Nat Rev Immunol. 2004 Mar;4(3):211-22
15039758
Nat Rev Immunol. 2003 Nov;3(11):867-78
14668803
J Immunol. 2001 Sep 1;167(5):2666-70
11509609
J Exp Med. 1976 Sep 1;144(3):828-33
956727
Science. 2006 Sep 29;313(5795):1960-4
17008531
Science. 1976 Jul 16;193(4249):237-9
935867
Cancer Res. 2001 Sep 15;61(18):6860-7
11559562
Int J Hyperthermia. 2000 Jan-Feb;16(1):45-59
10669316
Rev Infect Dis. 1991 May-Jun;13(3):462-72
1866550
J Dermatol Sci. 1997 Aug;15(2):75-81
9279687
Physiol Rev. 1991 Jan;71(1):93-127
1986393
FASEB J. 2001 Jan;15(1):43-58
11149892
Int J Radiat Oncol Biol Phys. 2001 Apr 1;49(5):1259-66
11286832
Cancer Immunol Immunother. 2006 Mar;55(3):292-8
15864585
Annu Rev Immunol. 2004;22:129-56
15032576
Microbes Infect. 2000 Dec;2(15):1891-904
11165933
J Immunol. 1999 Mar 15;162(6):3615-24
10092822
Blood. 2001 May 1;97(9):2727-33
11313264
Cancer Res. 2004 Mar 15;64(6):2183-91
15026361
J Immunol. 2005 Sep 15;175(6):3463-8
16148087
Immunity. 2004 Jan;20(1):59-70
14738765
Cancer Immunol Immunother. 1999 Oct;48(7):386-95
10501852
Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):258-63
9419363
Nat Immunol. 2006 Dec;7(12):1299-308
17086187
J Exp Med. 2000 Jan 3;191(1):61-76
10620605