Enantioselective addition of terminal alkynes to aldehydes catalyzed by a Cu(I)-TRAP complex.
The addition of terminal alkynes to aromatic aldehydes was carried out under mild conditions in the presence of a Cu-phosphine complex, which was prepared in situ from Cu(O-t-Bu) and TRAP chiral bisphosphine, to yield enantiomerically enriched propargyl alcohols with moderate enantioselectivities. Furthermore, according to stoichiometric reactions, the reaction presumably involves the addition of a TRAP-coordinated Cu(I) acetylide to an aldehyde.
Asano
Yohsuke
Y
Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
Hara
Kenji
K
Ito
Hajime
H
Sawamura
Masaya
M