title: The relation of low-level prenatal lead exposure to behavioral indicators of attention in Inuit infants in Arctic Quebec.
abstract: The aim of this study was to investigate the association between prenatal exposure to lead (Pb) and several aspects of behavioral function during infancy through examiner ratings and behavioral coding of video recordings. The sample consisted of 169 11-month-old Inuit infants from Arctic Quebec. Umbilical cord and maternal blood samples were used to document prenatal exposure to Pb. Average blood Pb levels were 4.6 mug/dL and 5.9 mug/dL in cord and maternal samples respectively. The Behavior Rating Scales (BRS) from the Bayley Scales of Infant Development (BSID-II) were used to assess behavior. Attention was assessed through the BRS and behavioral coding of video recordings taken during the administration of the BSID-II. Whereas the examiner ratings of behaviors detected very few associations with prenatal Pb exposure, cord blood Pb concentrations were significantly related to the direct observational measures of infant attention, after adjustment for confounding variables. These data provide evidence that increasing the specificity and the precision of the behavioral assessment has considerable potential for improving our ability to detect low-to-moderate associations between neurotoxicants, such Pb and infant behavior.
authors: Public Health Research Unit, CHUQ Research Center (CHUL), Sainte-Foy, Québec, Canada G1V 2M2.
authors: P
authors: P
authors: Plusquellec
authors: G
authors: G
authors: Muckle
authors: E
authors: E
authors: Dewailly
authors: P
authors: P
authors: Ayotte
authors: S W
authors: SW
authors: Jacobson
authors: J L
authors: JL
authors: Jacobson
mesh_terms: D000328:Adult; D001110:Arctic Regions; D001288:Attention / Q000187:drug effects*; D002657:Child Development / Q000187:drug effects; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007223:Infant; D018730:Infant Behavior / Q000187:drug effects; D007229:Infant Welfare; D007231:Infant, Newborn; D004930:Inuit; D007854:Lead / Q000097:blood; D020263:Lead Poisoning, Nervous System / Q000523:psychology*; D008297:Male; D009483:Neuropsychological Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*; D011446:Prospective Studies; D011792:Quebec
chemical_list: D007854:Lead
references: Neurotoxicol Teratol. 2001 Nov-Dec;23(6):511-8
references: 11792521
references: Arch Environ Health. 1999 Jan-Feb;54(1):40-7
references: 10025415
references: N Engl J Med. 1979 Mar 29;300(13):689-95
references: 763299
references: Brain Res Brain Res Rev. 1998 Jul;27(2):168-76
references: 9622620
references: Lancet. 2003 May 17;361(9370):1686-92
references: 12767734
references: Neurotoxicol Teratol. 2004 May-Jun;26(3):359-71
references: 15113598
references: Neurotoxicol Teratol. 2001 Nov-Dec;23(6):519-31
references: 11792522
references: Neurotoxicol Teratol. 1989 Mar-Apr;11(2):85-93
references: 2733657
references: Pediatrics. 2001 May;107(5):1016-23
references: 11331680
references: Arch Environ Health. 1996 May-Jun;51(3):214-20
references: 8687242
references: Pediatrics. 1987 Nov;80(5):721-30
references: 2444921
references: Neuropsychol Rev. 1991 Jun;2(2):109-45
references: 1844706
references: Environ Health Perspect. 1990 Nov;89:13-9
references: 2088739
references: Early Hum Dev. 1999 Jan;53(3):251-69
references: 10088991
references: Acta Obstet Gynecol Scand. 1999 Nov;78(10):852-60
references: 10577613
references: Am J Epidemiol. 1999 Apr 15;149(8):740-9
references: 10206624
references: Neurotoxicol Teratol. 1998 Sep-Oct;20(5):511-21
references: 9761589
references: Arch Environ Health. 1994 Mar-Apr;49(2):98-105
references: 8161248
references: Child Dev. 1997 Feb;68(1):139-43
references: 9084130
references: Environ Res. 1985 Oct;38(1):119-29
references: 3841053
references: Environ Health Perspect. 1996 Oct;104(10):1050-4
references: 8930545
references: Environ Res. 1998 May;77(2):165-72
references: 9600810
references: Sci Total Environ. 2003 Feb 15;303(1-2):79-104
references: 12568766
references: Environ Health Perspect. 2001 Dec;109(12):1291-9
references: 11748038
references: Dev Psychobiol. 1988 May;21(4):371-82
references: 3378682
references: Environ Res. 1998 Oct;79(1):1-8
references: 9756675
references: Neurotoxicol Teratol. 1989 May-Jun;11(3):205-13
references: 2787889
references: Neurotoxicology. 1993 Summer-Fall;14(2-3):167-78
references: 8247391
references: Dev Med Child Neurol. 2004 Dec;46(12):825-31
references: 15581156
references: Sci Total Environ. 1984 Dec;40:45-60
references: 6523134
references: Int Arch Occup Environ Health. 1983;51(3):231-52
references: 6852930
references: Neurobehav Toxicol Teratol. 1986 Mar-Apr;8(2):151-61
references: 2423895
references: Neurotoxicol Teratol. 2001 Jan-Feb;23(1):13-21
references: 11274872
references: Neurotoxicol Teratol. 1990 Jul-Aug;12(4):319-26
references: 2118230
references: Invest Ophthalmol Vis Sci. 2002 Jun;43(6):2036-44
references: 12037016
references: Neurotoxicol Teratol. 2000 Jul-Aug;22(4):503-10
references: 10974588
references: J Appl Toxicol. 1999 May-Jun;19(3):167-72
references: 10362267
references: Annu Rev Psychol. 2001;52:337-67
references: 11148309
references: Int J Epidemiol. 1989 Mar;18(1):180-5
references: 2722362
references: Am J Public Health. 1992 Oct;82(10):1356-60
references: 1415859
references: JAMA. 1996 Feb 7;275(5):363-9
references: 8569015
references: Environ Health Perspect. 2006 Nov;114(11):1730-5
references: 17107860
references: Occup Environ Med. 2003 Sep;60(9):693-5
references: 12937194
references: J Child Psychol Psychiatry. 1988 Nov;29(6):811-24
references: 3235491
references: Am J Public Health. 1998 Mar;88(3):481-6
references: 9518990
references: Neurotoxicol Teratol. 1990 May-Jun;12(3):215-29
references: 2196421
references: N Engl J Med. 1987 Apr 23;316(17):1037-43
references: 3561456
references: Am J Public Health. 1994 Mar;84(3):415-21
references: 8129058
references: Environ Res. 1985 Oct;38(1):137-43
references: 4076102
references: Environ Health Perspect. 2001 May;109(5):527-32
references: 11401766
references: Environ Health Perspect. 2006 May;114(5):791-7
references: 16675439
references: Pediatrics. 1998 Mar;101(3):E10
references: 9481029
references: Pediatrics. 1986 Jun;77(6):826-33
references: 3714374
references: Environ Res. 1994 Jul;66(1):12-30
references: 8013435
references: Environ Res. 2002 May;89(1):1-11
references: 12051779
references: Neurotoxicology. 1994 Fall;15(3):695-9
references: 7854608
references: Neurotoxicol Teratol. 2006 Jan-Feb;28(1):18-27
references: 16337107
references: Arch Environ Health. 1986 Sep-Oct;41(5):287-91
references: 3800431
references: J Paediatr Child Health. 2001 Oct;37(5):423-5
references: 11885702