Coordination of copper with aspirin enhances its anti-platelet aggregation activity.
Anti-platelet aggregation of copper aspirinate, a copper complex of aspirin, has been studied in vitro and in vivo. The result shows that copper aspirinate is much more effective than aspirin against AA-, ADP- and PAF-induced platelet aggregation. Its mechanism is related to the inhibition of platelet cyclooxygenase and release of active substances from platelets, and to the promotion of PGI(2) level in plasma.
Weiping
L
L
Institute of Precious Metals, 650221, Kunming.
Yang
Y K
YK
Xiong
H Z
HZ
Cheng
X Z
XZ
Chen
Z H
ZH
Shen
Z Q
ZQ
Li
L
L
J Med Chem. 1976 Jan;19(1):135-48
1246036
Nature. 1962 Jun 9;194:927-9
13871375
Prog Med Chem. 1989;26:437-568
2690187