TGFB1 single nucleotide polymorphisms are associated with adverse quality of life in prostate cancer patients treated with radiotherapy.
OBJECTIVE
To investigate whether the presence of single nucleotide polymorphisms (SNPs) located within TGFB1 might be predictive for the development of adverse quality-of-life outcomes in prostate cancer patients treated with radiotherapy.


METHODS
A total of 141 prostate cancer patients treated with radiotherapy were screened for SNPs in TGFB1 using DNA sequencing. Three quality-of-life outcomes were investigated: (1) prospective decline in erectile function, (2) urinary quality of life, and (3) rectal bleeding. Median follow-up was 51.3 months (range, 12-138 months; SD, 24.4 months).


RESULTS
Those patients who possessed either the T/T genotype at position -509, the C/C genotype at position 869 (pro/pro, codon 10) or the G/C genotype at position 915 (arg/pro, codon 25) were significantly associated with the development of a decline in erectile function compared with those who did not have these genotypes: 56% (9 of 16) vs. 24% (11 of 45) (p = 0.02). In addition, patients with the -509 T/T genotype had a significantly increased risk of developing late rectal bleeding compared with those who had either the C/T or C/C genotype at this position: 55% (6 of 11) vs. 26% (34 of 130) (p = 0.05).


CONCLUSIONS
Possession of certain TGFB1 genotypes is associated with the development of both erectile dysfunction and late rectal bleeding in patients treated with radiotherapy for prostate cancer. Therefore, identification of patients harboring these genotypes may represent a means to predict which men are most likely to suffer from poor quality-of-life outcomes after radiotherapy for prostate cancer.
Peters
Christopher A
CA
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA. christopher.peters@mountsinai.org
Stock
Richard G
RG
Cesaretti
Jamie A
JA
Atencio
David P
DP
Peters
Sheila
S
Burri
Ryan J
RJ
Stone
Nelson N
NN
Ostrer
Harry
H
Rosenstein
Barry S
BS
D000368:Aged; D007172:Erectile Dysfunction / Q000209:etiology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000528:radiation effects; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000532:radiotherapy*; D011788:Quality of Life; D012007:Rectum / Q000528:radiation effects; D053773:Transforming Growth Factor beta1 / Q000235:genetics* / Q000502:physiology; D014555:Urination Disorders / Q000209:etiology
D053773:Transforming Growth Factor beta1