title: Assessment of left ventricular function: comparison of cardiac multidetector-row computed tomography with two-dimension standard echocardiography for assessment of left ventricular function.
abstract: OBJECTIVE
  To compare global Left Ventricular (LV) systolic function assessment by 16-detector row Computed Tomography (MDCT) with Two-Dimensional Standard Echocardiography (2DSE) in a routine cardiology practice setting and to ascertain the degree of correlation between LV volumes and measurements obtained by 2DSE with those measured by MDCT.
  
  
  METHODS
  In 52 patients with suspected coronary artery disease, a contrast enhanced MDCT study was performed using retrospective gating without dose modulation for better endocardial delineation. Eight phases of the cardiac cycle were analyzed to identify the end-diastolic and end-systolic phases. 2DSE was performed on the same day. Left ventricular systolic and diastolic volumes and ejection fraction were calculated in 4-chamber, 2-chamber and biplane (average of the two) views. Endocardial tracing was used to measure ventricular volumes by area length method for CT and Simpson's method for echocardiography.
  
  
  RESULTS
  On MDCT, mean LV ejection fraction (LVEF) in 4-chamber, 2-chamber and biplane views were 58.4 +/- 12, 59.3 +/- 12 and 59.7 +/- 12% respectively. On 2DSE, mean LVEF in 4-chamber, 2-chamber and biplane views were 58 +/- 14, 57 +/- 16 and 58 +/- 13% respectively. LVEF correlated best using the biplane views (r = 0.59 and P < 0.01) compared to 2-chamber (r = 0.57 and P < 0.01) and 4-chamber views (r = 0.32 and P = 0.02). Biplane measurement by these two techniques correlated well for LV volumes in both diastole (r = 0.69 and P < 0.01) and systole (r = 0.73 and P < 0.01), although MDCT consistently gave higher values.
  
  
  CONCLUSIONS
  MDCT can be a useful tool to measure LVEF while patients are undergoing CT coronary angiography.
authors: Division of Cardiovascular Medicine, Arkansas Cardiology and the Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, 4301 W. Markham St., Slot 532, Little Rock, AR 72205, USA.
authors: Darpan
authors: D
authors: Bansal
authors: Robin M
authors: RM
authors: Singh
authors: Mrinalini
authors: M
authors: Sarkar
authors: Ravi
authors: R
authors: Sureddi
authors: Kelly C
authors: KC
authors: Mcbreen
authors: Timothy
authors: T
authors: Griffis
authors: Anjan
authors: A
authors: Sinha
authors: Jawahar L
authors: JL
authors: Mehta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013318:Stroke Volume; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*
chemical_list: D003287:Contrast Media
references: Compr Ther. 1979 Jul;5(7):47-54
references: 477284
references: N Engl J Med. 1983 Aug 11;309(6):331-6
references: 6866068
references: J Comput Assist Tomogr. 1996 Nov-Dec;20(6):942-9
references: 8933796
references: Lancet. 1986 Feb 8;1(8476):307-10
references: 2868172
references: Eur J Echocardiogr. 2006 Aug;7(4):308-14
references: 16098814
references: Circulation. 1981 Sep;64(3):535-44
references: 7261286
references: Echocardiography. 1999 Oct;16(7, Pt 2):747-752
references: 11175218
references: Int J Cardiovasc Imaging. 2003 Feb;19(1):73-83
references: 12602485
references: Circulation. 1979 Oct;60(4):760-6
references: 476879
references: Am Heart J. 1990 Jun;119(6):1367-73
references: 2141222
references: Circulation. 2006 Aug 15;114(7):654-61
references: 16894035
references: Am J Cardiol. 1996 Dec 15;78(12 ):1327-37
references: 8970402