Effects of amlodipine, captopril, and bezafibrate on oxidative milieu in rats with fatty liver.
Oxidative stress may initiate significant hepatocyte injury in subjects with fatty liver. We characterized changes in hepatic oxidative anti-oxidative parameters in rats given a fructose-enriched diet (FED) with and without medications to reduce blood pressure or plasma triglycerides. FED rats had an increase in malondialdehyde (MDA) concentration, a reduction in alpha-tocopherol concentration, a reduction in paraoxonase (PON) activity, an increase in glutathione peroxidase (GSH-Px), and glutathione reductase (GSSG-R) activity. Amlodipine increased PON and GSH-Px, but decreased GSSG-R activity and alpha-tocopherol concentration. Captopril decreased MDA concentration and the activity of both GSH-Px and GSSG-R, but increased alpha-tocopherol concentration and PON activity. Bezafibrate increased alpha-tocopherol concentration and PON activity, but decreased the activity of GSSG-R. Animals with fatty liver exhibit an increase in peroxidative stress but also a defect in anti-oxidative pathways. Drugs administered to treat hypertension and hypertriglyceridemia could lead to a variety of changes in the hepatic oxidative, anti-oxidative milieu.
Ackerman
Zvi
Z
Department of Medicine, Hadassah-Hebrew University Medical Center, Mount Scopus Campus, Jerusalem 91240, Israel. zackerman@hadassah.org.il
Oron-Herman
Mor
M
Rosenthal
Talma
T
Pappo
Orit
O
Link
Gabriela
G
Sela
Ben-Ami
BA
Grozovski
Maria
M
D017311:Amlodipine / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001629:Bezafibrate / Q000494:pharmacology / Q000627:therapeutic use; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use; D005234:Fatty Liver / Q000150:complications / Q000188:drug therapy*; D005632:Fructose / Q000009:adverse effects*; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000188:drug therapy; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000959:Antihypertensive Agents; D000960:Hypolipidemic Agents; D017311:Amlodipine; D005632:Fructose; D002216:Captopril; D001629:Bezafibrate
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