title: Psychoneuroendocrine stress response may impair neutrophil function in complex regional pain syndrome.
abstract: In order to elucidate the interaction between pain, stress and innate immunity in complex regional pain syndrome (CRPS), we assessed pain and stress levels in CRPS patients and compared ex vivo functions of neutrophils between patients with CRPS and healthy volunteers. As compared with healthy volunteers, the following major alterations in CRPS patients were found: (I) elevated stress score (PTSS-10) and stress hormone concentrations, (II) decreased expression of the CD62L and CD11b/CD18 on neutrophils, (III) impaired ability of autologous plasma to enhance the capability of neutrophils to phagocytose zymosan particles, and (IV) a negative correlation between PTSS-10 values and autologous plasma enhanced phagocytosis. In vitro incubation of neutrophils with catecholamines decreased phagocytosis of zymosan. In conclusion, CRPS patients exhibit signs of impaired innate immunity which might reflect the immunological consequence of an immunosuppressive neuroendocrine stress response.
authors: Department of Anesthesiology, Klinikum Grosshadern, Ludwig-Maximilians-University, 81377, Munich, Germany.
authors: Ines
authors: I
authors: Kaufmann
authors: Christoph
authors: C
authors: Eisner
authors: Peter
authors: P
authors: Richter
authors: Volker
authors: V
authors: Huge
authors: Antje
authors: A
authors: Beyer
authors: Alexander
authors: A
authors: Chouker
authors: Gustav
authors: G
authors: Schelling
authors: Manfred
authors: M
authors: Thiel
mesh_terms: D015815:Cell Adhesion Molecules / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D020918:Complex Regional Pain Syndromes / Q000276:immunology* / Q000503:physiopathology / Q000523:psychology*; D004837:Epinephrine / Q000097:blood; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D018375:Neutrophil Activation / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D009638:Norepinephrine / Q000097:blood; D013315:Stress, Psychological / Q000209:etiology / Q000276:immunology*
chemical_list: D015815:Cell Adhesion Molecules; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine