title: Prognostic value of HER2 and progesterone receptor expression in endometrial carcinoma with positive peritoneal washing.
abstract: BACKGROUND
  Although the majority of endometrial cancer (EC) patients can be cured by surgery, unexpected recurrent disease may also occur in early stage patients. In the present study, whether or not the analysis of multiple biopathological parameters might lead to more accurate predictions of the clinical outcome of EC patients with long-term follow-up (FU) was investigated.
  
  
  METHODS
  Estrogen and progesterone receptor (ER and PgR) positivity and HER2 overexpression by immunohistochemistry were evaluated. The peritoneal washings (PWs) were analyzed by cytology and immunocytochemistry employing AR-3 and B72.3 monoclonal antibodies.
  
  
  RESULTS
  The patients with positive PW and HER2 positive tumors showed shorter overall survival compared to those bearing HER2 negative tumors (p =0.004). HER2 overexpression also influenced the patient outcome in the group with tumors lacking PgR (p = 0.004). At multivariate analysis PgR and HER2 overexpression emerged as independent prognostic factors.
  
  
  CONCLUSIONS
  The combined analysis of these biopathological markers could provide useful information for the selection of patients to be enrolled in innovative therapeutic strategies.
authors: Departments of Pathology, Regina Elena Cancer Institute, 00144, Rome, Italy.
authors: Maria
authors: M
authors: Benevolo
authors: Amina
authors: A
authors: Vocaturo
authors: Flavia
authors: F
authors: Novelli
authors: Luciano
authors: L
authors: Mariani
authors: Giuseppe
authors: G
authors: Vocaturo
authors: Anna Maria
authors: AM
authors: Cianciulli
authors: Ferdinando
authors: F
authors: Marandino
authors: Raffaele
authors: R
authors: Perrone-Donnorso
authors: Diana
authors: D
authors: Giannarelli
authors: Pier Giorgio
authors: PG
authors: Natali
authors: Marcella
authors: M
authors: Mottolese
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D010529:Peritoneal Cavity / Q000473:pathology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D011960:Receptors, Estrogen / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis*; D015996:Survival Rate
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone