title: Mice left out in the cold: commentary on the phenotype of TRPM8-nulls.
abstract: Detection of innocuous temperatures allows an organism to select an appropriate environmental climate, while the ability to recognize noxious temperature extremes warns of impending tissue damage. For temperatures considered cold, the menthol receptor TRPM8 is activated when temperatures drop below approximately 26 degrees C, thus making it an intriguing candidate as the molecular mediator of cold perception. However, confirmation of this hypothesis in vivo has eluded researchers until recently. Three independent research groups have reported that mice lacking this single gene are severely impaired in their ability to detect cold temperatures. Remarkably, these animals are deficient in many diverse aspects of cold signaling, including cool and noxious cold perception, injury-evoked sensitization to cold, and cooling-induced analgesia. These animals provide a great deal of insight into the molecular signaling pathways that participate in the detection of cold and painful stimuli.
authors: Neuroscience Graduate Program, Department of Biological Sciences, and School of Dentistry, University of Southern California, Los Angeles, CA90089-0641, USA. rldaniel@usc.edu
authors: Richard L
authors: RL
authors: Daniels
authors: David D
authors: DD
authors: McKemy
mesh_terms: D000818:Animals; D003080:Cold Temperature; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D012684:Sensory Thresholds / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics; D050053:TRPM Cation Channels / Q000172:deficiency*; D013697:Thermosensing
chemical_list: D050053:TRPM Cation Channels; C492297:TRPM8 protein, mouse
references: J Neurobiol. 2004 Oct;61(1):3-12
references: 15362149
references: Nature. 2004 Jan 15;427(6971):260-5
references: 14712238
references: Eur J Neurosci. 2004 Nov;20(9):2276-82
references: 15525269
references: Cell. 2006 Mar 24;124(6):1269-82
references: 16564016
references: Neuron. 2006 Apr 20;50(2):177-80
references: 16630827
references: Neuron. 2006 Apr 20;50(2):277-89
references: 16630838
references: Curr Biol. 2006 Aug 22;16(16):1591-605
references: 16920620
references: Nat Neurosci. 2007 Mar;10(3):277-9
references: 17259981
references: Exp Brain Res. 2007 Mar;178(1):89-98
references: 17006682
references: J Biol Chem. 2007 May 4;282(18):13180-9
references: 17353192
references: Neuron. 2007 May 3;54(3):345-7
references: 17481385
references: Neuron. 2007 May 3;54(3):371-8
references: 17481391
references: Neuron. 2007 May 3;54(3):379-86
references: 17481392
references: Nature. 2007 Jun 14;447(7146):855-8
references: 17568746
references: Nature. 2007 Jul 12;448(7150):204-8
references: 17538622
references: Brain Res. 2007 Jul 30;1160:39-46
references: 17588549
references: Mol Pain. 2005;1:16
references: 15847696
references: Nature. 2001 Sep 13;413(6852):203-10
references: 11557989
references: Nat Neurosci. 2002 Mar;5(3):254-60
references: 11836533
references: Nature. 1997 Oct 23;389(6653):816-24
references: 9349813