Prevalence of OPG and IL-1 gene polymorphisms in chronic periodontitis.
OBJECTIVE
To investigate the association of polymorphisms in the osteoprotegerin (OPG) and interleukin 1 (IL-1) genes with chronic periodontitis (CP).


METHODS
One hundred and ninety-four individuals (97 CP patients, 97 controls) were genotyped for the OPG polymorphisms Lys3Asn and Met256Val and for the IL-1 polymorphisms IL-1A (-889C/T) and IL-1B (+3953C/T).


RESULTS
The homozygous variants coding for Lys3 were present at a higher frequency, whereas Asn3 and Met256 were present at a lower frequency in CP patients/controls (Lys3: 31%/25%, Asn3: 23%/32% and Met256: 66%/73%). Heterozygosity for Lys3Asn was observed at a higher frequency in CP patients/controls (46%/43%). Homozygosity for the Val256 genotype was observed in two CP patients (one in controls). Met256Val heterozygosity was more prevalent in CP patients/controls (32%/20%). All differences were statistically not significant between CP patients and controls. In contrast, both IL-1 polymorphisms were statistically significant. The heterozygous variant for IL-1A was present in 32% of the CP patients and in 20% of the controls (homozygosity (patients/controls) CC: 10%/21% and TT: 55%/33%). Heterozygosity for IL-1B was observed in 37% of the CP patients versus 34% in the controls (homozygosity (patients/controls) CC: 26%/57% and TT: 37%/9%).


CONCLUSIONS
While the association between the IL-1 polymorphisms and CP was confirmed, no association between the OPG polymorphisms and CP could be found.
Wagner
Judith
J
Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany. judith.wagner@klinik.uni-regensburg.de
Kaminski
Wolfgang E
WE
Aslanidis
Charalampos
C
Moder
Daniel
D
Hiller
Karl-Anton
KA
Christgau
Michael
M
Schmitz
Gerd
G
Schmalz
Gottfried
G
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002908:Chronic Disease; D017931:DNA Primers; D005260:Female; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000235:genetics*; D010518:Periodontitis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D017931:DNA Primers; D007375:Interleukin-1; D053244:Osteoprotegerin