title: [The experimental study on biodegradable gel membrane applied to prevention of postoperative adhesion of abdominal cavity surgery].
abstract: OBJECTIVE
  To develop a new type of anti-adhesion gel membrane and explore its applying technique.
  
  
  METHODS
  24 adult New Zealand white rabbits were used for the experiment research project, the animals were divided into two groups: the experiment group (18 adult New Zealand white rabbits) and the control group (6 adult New Zealand white rabbits). The animal models were established via the abdominal cavity. The biodegradable gel membrane was covered to the surface of the operating region in experimental animal group, while the 0.9% NaCL was directly rinsing the operating region in the controlled group. The specimens were collected at postoperatively week 2, 4 or 8 respectively. The samples were evaluated by global and histological observation.
  
  
  RESULTS
  In the experiment group, a few adhed zones were observed in 2 and 4 weeks after operation, but in 8 weeks after operation, the adhesion zone was disappeared. In the control group, a few adheol zones were founded in 2 weeks after operation. In 4 weeks after operation, the adhed zone become conspicuously emerged. In 8 weeks after operation, the cicatri band was occurred.
  
  
  CONCLUSIONS
  The biodegradable gel membrane usd into the postoperative abdominal cavity is effective and easy to manipulate, and it could be used as a high-effect, cheap drug of anti-adhesion in operation for surgeons.
authors: Key Lab. of Biomedical Engineering, Sichuan University, Chengdu 610041, China.
authors: Ju-kun
authors: JK
authors: Song
authors: Chong-yun
authors: CY
authors: Bao
authors: Ming-long
authors: ML
authors: Yuan
authors: Yun-ping
authors: YP
authors: Ding
authors: Jing-lin
authors: JL
authors: Zhou
authors: Jing
authors: J
authors: Xue
authors: Hua-zhou
authors: HZ
authors: Jiang
authors: Yun-mao
authors: YM
authors: Liao
authors: Wei
authors: W
authors: Li
mesh_terms: D034841:Abdominal Cavity / Q000473:pathology* / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D005260:Female; D005782:Gels; D008297:Male; D008567:Membranes, Artificial; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D013997:Time Factors; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D001672:Biocompatible Materials; D005782:Gels; D008567:Membranes, Artificial