Narcotrend-assisted propofol/remifentanil anaesthesia vs clinical practice: does it make a difference?
BACKGROUND
The Narcotrend is a computer-based EEG monitor designed to measure the depth of anaesthesia. The aim of the present study is to test the hypothesis that the intraoperative level of anaesthetic depth differs if decision-making is guided by Narcotrend monitoring or not.


METHODS
Forty-eight patients undergoing elective surgery were randomized to receive a Narcotrend-controlled propofol/remifentanil anaesthetic regimen or standard clinical practice. In the EEG group, anaesthesia was adjusted to achieve a Narcotrend level of D2-E0, which is recommended for moderate to deep anaesthetic depth for surgery. EEG values were recorded continuously every 20 s in both groups. Depending on data distribution, group comparisons of the EEG parameters, propofol plasma concentration, and recovery characteristics were performed by analysis of variance for repeated measurements or non-parametric statistics.


RESULTS
About 62 (sd 29)% of the Narcotrend values were within the target level in the EEG group during maintenance of anaesthesia; this was true for 64 (26)% of the data in the non-EEG group. The variance of the Narcotrend data was significantly lower in the EEG group compared with the non-EEG group [median: 0.4 (range: 3.5) vs 0.6 (2.5); P = 0.048]. There was no difference in propofol or remifentanil dosage, propofol plasma concentrations, and time for extubation. Ten minutes after extubation, visual analogue scores for nausea indicated a lower incidence in the Narcotrend group [7 (15) vs 24 (34); P = 0.005].


CONCLUSIONS
Guidance of anaesthesia with the Narcotrend-monitor leads to fewer deviations from a defined target than clinical assessment of anaesthetic depth only. This results in lower scores of nausea in the immediate period after anaesthesia.
Rundshagen
I
I
Department of Anaesthesiology, Universitätsmedizin Berlin, Campus Charité Mitte, Schumannstr., 20/21, D-10117 Berlin, Germany. ingrid.rundshagen@charite.de
Hardt
T
T
Cortina
K
K
Pragst
F
F
Fritzsche
T
T
Spies
C
C
D000328:Adult; D000701:Analgesics, Opioid / Q000494:pharmacology; D000762:Anesthesia Recovery Period; D019162:Anesthetics, Combined / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000097:blood / Q000494:pharmacology*; D020878:Device Removal; D004569:Electroencephalography / Q000187:drug effects* / Q000379:methods; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D010880:Piperidines / Q000494:pharmacology*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control; D015742:Propofol / Q000097:blood / Q000494:pharmacology*; D011446:Prospective Studies; D000077208:Remifentanil; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
D000701:Analgesics, Opioid; D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil; D015742:Propofol