title: Longitudinal study of serum lipids and liver enzymes in workers with occupational exposure to ammonium perfluorooctanoate.
abstract: OBJECTIVE
  To examine the relationship between serum perfluorooctanoate (PFOA), a biomarker of ammonium perfluorooctanoate exposure, and lipids and liver enzymes.
  
  
  METHODS
  We conducted a longitudinal study on 454 workers and used mixed models to examine the relationship between serum PFOA and lipids and liver enzymes.
  
  
  RESULTS
  One part per million (ppm) increase in serum PFOA was associated with a 1.06 mg/dL increase in total cholesterol, but was not associated with changes in triglycerides or other lipoproteins, after adjusting for potential confounders. Serum PFOA was also associated with total bilirubin (0.008 mg/dL decline/ppm) and serum aspartate aminotransferase (0.35 units increase/ppm) but not with the other liver enzymes.
  
  
  CONCLUSIONS
  These medical surveillance data collected on workers for up to 25 years contributes useful information on the effects of ammonium perfluorooctanoate exposure on human liver and lipid chemistry.
authors: Yale University School of Medicine, New Haven, Connecticut, USA. carine.sakr@yale.edu
authors: Carine J
authors: CJ
authors: Sakr
authors: Robin C
authors: RC
authors: Leonard
authors: Kim H
authors: KH
authors: Kreckmann
authors: Martin D
authors: MD
authors: Slade
authors: Mark R
authors: MR
authors: Cullen
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002210:Caprylates / Q000009:adverse effects* / Q000097:blood*; D002617:Chemical Industry; D002784:Cholesterol / Q000097:blood; D005260:Female; D005466:Fluorocarbons / Q000009:adverse effects* / Q000097:blood*; D006801:Humans; D008111:Liver Function Tests; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D002210:Caprylates; D005466:Fluorocarbons; D014280:Triglycerides; C023036:perfluorooctanoic acid; D002784:Cholesterol