title: In vitro antiviral effect of meroditerpenes isolated from the Brazilian seaweed Stypopodium zonale (Dictyotales).
abstract: The meroditerpenoids atomaric acid (1), epitaondiol (2) and the peroxylactone of 5'a-desmethyl-5'-acetylatomaric acid (3) were isolated from the Brazilian brown alga Stypopodium zonale collected in two localities (Búzios and Marataízes, RJ and ES States). These compounds showed strong anti-HSV-1 activity in vitro but neither of them inhibited the transcriptase reverse enzyme of HIV-1.
authors: Programa de Pós-Graduação em Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Niterói, RJ, Brazil.
authors: Angelica Ribeiro
authors: AR
authors: Soares
authors: Juliana Lourenço
authors: JL
authors: Abrantes
authors: Thiago Moreno
authors: TM
authors: Lopes Souza
authors: Carlos Frederico
authors: CF
authors: Leite Fontes
authors: Renato Crespo
authors: RC
authors: Pereira
authors: Izabel Christina
authors: IC
authors: de Palmer Paixão Frugulhetti
authors: Valéria Laneuville
authors: VL
authors: Teixeira
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001938:Brazil; D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012624:Seaweed
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes; D010936:Plant Extracts