Cytochrome P450IA1 polymorphisms along with PM(10) exposure contribute to the risk of birth weight reduction.
We explored the effects of particulate matter <10 microm (PM(10)) exposure along with CYP1A1 polymorphisms of MspI (T6235C) and NcoI (Ile462Val) on reduced birth weight (BW). A prospective cohort study was done with women who delivered from 2001 to 2004 at Ewha Womans University Hospital, Seoul, Korea. We compared the estimated least squares means of BW in the generalized linear model, after adjusting for controlling factors. High PM(10) exposure at the 90th percentile level and above during the 1st trimester conferred a significant risk for reduced BW, compared with low PM(10) exposure below the 90th percentile level. The effect of high PM(10) exposure during the 1st trimester of pregnancy compared with low PM(10) exposure was greater for women with MspI TC/CC and NcoI IleVal/ValVal genotypes than for those with MspI TT and NcoI IleIle genotypes. In conclusion, high PM(10) exposure during the 1st trimester increased the risk for reduced BW in concert with MspI TC/CC and NcoI IleVal/ValVal genotypes in Korean women.
Suh
Young-Ju
YJ
Department of Preventive Medicine, College of Medicine, Ewha Medical Research Center, Ewha Womans University, Yangcheon-Ku, Seoul, Republic of Korea.
Kim
Byung-Mi
BM
Park
Bo-Hyun
BH
Park
Hyesook
H
Kim
Young-Ju
YJ
Kim
Ho
H
Hong
Yun-Chul
YC
Ha
Eun-Hee
EH
D000328:Adult; D001724:Birth Weight / Q000187:drug effects*; D015331:Cohort Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics* / Q000378:metabolism; D015257:DNA-Cytosine Methylases / Q000235:genetics / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000209:etiology*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D006785:Hospitals, University; D006801:Humans; D007230:Infant, Low Birth Weight / Q000502:physiology*; D007231:Infant, Newborn; D007723:Korea / Q000453:epidemiology; D008297:Male; D010316:Particle Size; D052638:Particulate Matter / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011446:Prospective Studies
D006023:Glycoproteins; D052638:Particulate Matter; C021240:tissue-factor-pathway inhibitor 2; D019363:Cytochrome P-450 CYP1A1; C059640:DNA modification methylase NcoI; D015257:DNA-Cytosine Methylases