np1: a computer program for dose escalation strategies in phase I clinical trials.
The continual reassessment method is a recommended dose escalation design for including patients in phase I clinical trials designed to estimate the maximum tolerated dose. However, for a particular trial, the implementation of these methods requires extensive computer programming. Standard 3+3 designs do not require this, but have shown to possess poor statistical properties. np1 is a user friendly computer program which has implemented two continual reassessment methods for simulating and conducting a phase I clinical trial. Several options allow the user to investigate operating characteristics under various scenarios.
Kramar
Andrew
A
CRLC Val d'Aurelle-Paul Lamarque, Unité de Biostatistiques, Parc Euromedecine, 34298 Montpellier Cedex 5, France. andrew.kramar@valdorel.fnclcc.fr
Houédé
Nadine
N
Paoletti
Xavier
X
D001499:Bayes Theorem; D017321:Clinical Trials, Phase I as Topic / Q000379:methods*; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020714:Maximum Tolerated Dose; D012984:Software