[Neuroimmunomodulation: the cross-talk between nervous and immune systems].
OBJECTIVE
Several papers arriving from the neuroimmunomodulation field are showing the relevant relationships between the nervous and the immune systems. A review of studies was carried out to describe the bases of the studies on neuroimmunomodulation.
It is clear nowadays that emotional states such as anxiety and depression change immune system activity, an affect also observed after both stress and use of nervous system acting drugs.
The behavior displayed by sick organisms might be thought as being a consequence of homeostatic strategies.
A very big emphasis is being given to Hipothalamus-pituitary-adrenal axis, sympathetic nervous system and cytokines participation on nervous system and immune system relationships.


CONCLUSIONS
The present revision intend to show some essential studies in the neuroimmunomodulation field; it makes a critical analysis of the mutual relationships between nervous system and immune system.
Alves
Glaucie Jussilane
GJ
Fundação de Amparo à Pesquisa do Estado de São Paulo, Brasil.
Palermo-Neto
João
J
D000818:Animals; D002490:Central Nervous System / Q000276:immunology / Q000502:physiology* / Q000503:physiopathology; D016207:Cytokines / Q000276:immunology; D003863:Depression / Q000276:immunology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology; D007107:Immune System / Q000276:immunology / Q000502:physiology* / Q000503:physiopathology; D023421:Models, Animal; D015213:Neuroimmunomodulation / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000276:immunology; D013312:Stress, Physiological / Q000276:immunology*; D013315:Stress, Psychological / Q000276:immunology; D013564:Sympathetic Nervous System / Q000276:immunology
D016207:Cytokines