[Statistical analysis of the influence of the virus of papilloma human in the development of the vesical carcinoma].
BACKGROUND
The bladder cancer is an important disease by its morbi-mortality and its multifactorialidad. At the moment, between the possible aetiology agents that they have been indicated is the infection by the virus of papilloma human (VPH). The objective study is to analyse, by meta-analysis, the relationship between bladder cancer and infection by human papillomavirus.


METHODS
We made a search in the electronic data base MEDLINE of the articles published until September of the 2004 that relate the infection of the VPH to the bladder tumors. Of 414 listed articles, we selected 38 articles.


RESULTS
The articles were classified in two groups, according to they use or non methods based on the detection of the DNA. In articles based on the detection of the DNA, it was that the global proportion from the cases that had contact with the virus, through the detection of the genome was of the 19.4% (95% CI 0.160 to 0.228). Of the total of studies based on the detection of the DNA 8 were selected, to show to a group defined control, in which, the OR was investigated. If we combined the ORs, we obtain an OR estimation of 3.2 (95% CI 1.19 to 8.60) and p = 0.02.


CONCLUSIONS
Most of these studies showed the relation rose at the beginning of the study. Although the majority lacked a group defined control, is possible to analyze the value of the Odds global ratio due to the homogenous behaviour of the studies with defined cases and controls affluent. This demonstrated to association between VPH and the bladder cancer.
Jiménez Pacheco
A
A
Servicio de Urología, Hospital Universitario San Cecilio, Granada. anjipa29@hotmail.com
Martínez Torres
J I
JI
Pareja Vilchez
M
M
Arrabal Martín
M
M
Valle Díaz de la Guardia
F
F
López León
V
V
Zuluaga Gómez
A
A
D002294:Carcinoma, Squamous Cell / Q000821:virology*; D002295:Carcinoma, Transitional Cell / Q000821:virology*; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000821:virology*