title: Dendritic cells and the immunopathogenesis of systemic lupus erythematosus.
abstract: Over the last decade, the role of dendritic cells (DCs) in the immunopathogenesis of systemic lupus erythematosus (SLE) has become apparent. As unique mediators of both tolerance and immunity, aberrant myeloid and plasmacytoid DC function can promote autoimmune responses via a number of mechanisms and proinflammatory pathways. This review provides an overview of DC function, the potential role of DCs in promoting autoimmune responses in SLE, and how other abnormalities in lupus can lead to an enhanced engagement of DCs in immune responses. How medications used to treat SLE and other autoimmune conditions may exert effects on DCs is also explored.
authors: Division of Rheumatology, University of Michigan, 5520 MSRBI, Box 0680, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.
authors: Seetha
authors: S
authors: Monrad
authors: Mariana J
authors: MJ
authors: Kaplan
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
references: Crit Rev Immunol. 2005;25(2):123-40
references: 15952933
references: Arthritis Rheum. 2005 Oct;52(10):3063-72
references: 16200585
references: J Immunol. 2001 Nov 15;167(10):5963-9
references: 11698475
references: Immunology. 2002 Jul;106(3):326-35
references: 12100720
references: Ann N Y Acad Sci. 2005 Dec;1062:242-51
references: 16461805
references: Exp Dermatol. 2005 Jun;14(6):454-9
references: 15885081
references: Immunol Cell Biol. 2005 Oct;83(5):554-62
references: 16174107
references: J Immunol. 2004 Jul 1;173(1):189-96
references: 15210774
references: J Clin Invest. 2005 Feb;115(2):407-17
references: 15668740
references: J Autoimmun. 2003 Jun;20(4):287-9
references: 12791314
references: Cell. 2001 Aug 10;106(3):259-62
references: 11509173
references: Hum Immunol. 2002 Dec;63(12):1181-93
references: 12480262
references: J Immunol. 2004 Aug 1;173(3):2134-42
references: 15265950
references: Annu Rev Immunol. 2003;21:335-76
references: 12524386
references: Arthritis Rheum. 2005 May;52(5):1504-16
references: 15880822
references: Arthritis Rheum. 2005 Jan;52(1):225-38
references: 15641101
references: Autoimmunity. 2005 Nov;38(7):473-85
references: 16373252
references: Arthritis Res Ther. 2006;8(1):203
references: 16542467
references: Lupus. 2003;12(3):222-30
references: 12708787
references: Am J Pathol. 2001 Jul;159(1):237-43
references: 11438470
references: J Exp Med. 2000 Feb 7;191(3):423-34
references: 10662788
references: J Immunol. 2006 Aug 15;177(4):2088-96
references: 16887967
references: Rheum Dis Clin North Am. 2004 Aug;30(3):505-27, viii-ix
references: 15261339
references: Nat Rev Immunol. 2001 Nov;1(2):147-53
references: 11905822
references: Nature. 1992 Mar 26;356(6367):314-7
references: 1372394
references: Arthritis Rheum. 2004 Feb;50(2):629-39
references: 14872508
references: J Clin Invest. 2005 Jul;115(7):1869-78
references: 15951839
references: J Exp Med. 2003 Mar 17;197(6):711-23
references: 12642603
references: Nature. 1976 Sep 30;263(5576):420-2
references: 972680
references: J Immunol. 2004 Oct 15;173(8):5283-9
references: 15470074
references: Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5598-603
references: 15034168
references: Rheumatology (Oxford). 2006 Oct;45(10):1230-7
references: 16595513
references: Ann Rheum Dis. 2005 Dec;64(12 ):1692-7
references: 15843451
references: Immunol Today. 2000 Sep;21(9):424-6
references: 10953093
references: Stem Cells. 2002;20(1):61-72
references: 11796923
references: J Exp Med. 1998 Jan 5;187(1):79-87
references: 9419213
references: Science. 2006 Jun 16;312(5780):1669-72
references: 16709748
references: Arthritis Rheum. 2004 Jun;50(6):1861-72
references: 15188363
references: Int Immunol. 2004 Nov;16(11):1595-604
references: 15381672
references: Arthritis Rheum. 2006 May;54(5):1557-67
references: 16645989
references: Arthritis Rheum. 2003 Dec;48(12):3497-502
references: 14674000
references: J Immunol. 2006 Nov 1;177(9):5878-89
references: 17056512
references: Arthritis Rheum. 2001 Apr;44(4):856-65
references: 11315925
references: J Clin Invest. 2004 Jun;113(12):1722-33
references: 15199407
references: J Immunol. 2001 Aug 1;167(3):1740-7
references: 11466399
references: Rheumatology (Oxford). 2006 Sep;45(9):1087-95
references: 16527880
references: J Immunol. 2005 Apr 15;174(8):5100-9
references: 15814741
references: Curr Opin Rheumatol. 2003 Sep;15(5):542-7
references: 12960478
references: Autoimmun Rev. 2005 Mar;4(3):162-70
references: 15823502
references: Clin Exp Immunol. 2004 Oct;138(1):171-8
references: 15373921
references: Ann N Y Acad Sci. 2005 Jun;1051:421-32
references: 16126984
references: Semin Arthritis Rheum. 2004 Jun;33(6):404-13
references: 15190525
references: Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3372-7
references: 15728381
references: Hum Immunol. 2002 Dec;63(12):1172-80
references: 12480261
references: J Immunol. 2002 May 1;168(9):4531-7
references: 11970999
references: J Exp Med. 1995 Mar 1;181(3):839-44
references: 7869046
references: Clin Immunol. 2005 Dec;117(3):238-50
references: 16126005
references: Science. 2001 Nov 16;294(5546):1540-3
references: 11711679
references: Arthritis Rheum. 2003 Oct;48(10):2888-97
references: 14558095
references: Autoimmunity. 2003 Dec;36(8):511-8
references: 14984028
references: J Immunol. 1999 Dec 1;163(11):6306-13
references: 10570325
references: J Autoimmun. 1998 Oct;11(5):465-70
references: 9802930
references: J Immunol. 2000 Sep 1;165(5):2374-81
references: 10946260
references: J Immunol. 2002 Nov 15;169(10):6020-9
references: 12421989
references: J Immunol. 2002 Feb 15;168(4):1627-35
references: 11823490
references: J Exp Med. 2003 Mar 17;197(6):777-88
references: 12642605
references: Clin Rheumatol. 2005 Apr;24(2):107-10
references: 15818511
references: J Exp Med. 2005 Dec 5;202(11):1575-85
references: 16330816
references: Clin Immunol. 2004 Sep;112(3):210-8
references: 15308111
references: J Immunol. 2006 May 15;176(10):6022-33
references: 16670311
references: Arthritis Rheum. 2002 Jan;46(1):191-201
references: 11817590
references: J Exp Med. 2005 Jul 18;202(2):321-31
references: 16027240
references: Curr Opin Rheumatol. 2003 Sep;15(5):548-56
references: 12960479
references: Clin Immunol. 2004 Dec;113(3):224-30
references: 15507385
references: Curr Dir Autoimmun. 2005;8:124-39
references: 15564719
references: Eur J Immunol. 2005 Nov;35(11):3364-75
references: 16224814
references: Immunol Cell Biol. 2002 Oct;80(5):484-8
references: 12225385
references: J Exp Med. 2005 Oct 17;202(8):1131-9
references: 16230478
references: Blood. 2006 Apr 15;107(8):3229-34
references: 16368889
references: Clin Exp Immunol. 2001 Apr;124(1):118-25
references: 11359450
references: Arthritis Rheum. 2004 May;50(5):1549-60
references: 15146425
references: J Exp Med. 2005 Apr 4;201(7):1157-67
references: 15795237
references: Ann Rheum Dis. 2000 Apr;59(4):283-8
references: 10733475
references: Arthritis Res Ther. 2006;8(2):R49
references: 16507174
references: J Exp Med. 1998 Dec 7;188(11):2163-73
references: 9841929
references: Arthritis Rheum. 2006 Feb;54(2):408-20
references: 16447217
references: Annu Rev Immunol. 2000;18:767-811
references: 10837075
references: Lupus. 2001;10(7):484-90
references: 11480846
references: J Immunol. 2006 Feb 15;176(4):2095-104
references: 16455965
references: N Engl J Med. 1979 Jul 5;301(1):5-8
references: 449915
references: J Autoimmun. 2001 Aug;17(1):71-80
references: 11488639
references: Autoimmunity. 2003 Dec;36(8):481-90
references: 14984025
references: J Immunol. 2005 Aug 15;175(4):2692-701
references: 16081846
references: Curr Opin Immunol. 2000 Aug;12(4):419-24
references: 10899033
references: J Autoimmun. 1998 Oct;11(5):403-11
references: 9802923
references: J Immunol. 2004 Sep 1;173(5):3044-50
references: 15322164
references: Science. 2006 Jun 16;312(5780):1606-8
references: 16778043
references: J Exp Med. 2004 Jun 21;199(12):1631-40
references: 15197227
references: Autoimmunity. 2003 Dec;36(8):503-10
references: 14984027
references: J Immunol. 1998 Nov 1;161(9):4467-71
references: 9794367
references: Clin Exp Immunol. 1980 May;40(2):373-82
references: 6160000
references: J Immunol. 1999 Jun 1;162(11):6473-81
references: 10352262
references: Clin Exp Immunol. 2005 Oct;142(1):84-91
references: 16178860
references: Science. 1999 Jun 11;284(5421):1835-7
references: 10364556
references: J Exp Med. 1994 Apr 1;179(4):1317-30
references: 7511686
references: J Exp Med. 1998 Oct 5;188(7):1359-68
references: 9763615