Association of PTPN22 with rheumatoid arthritis among South Asians in the UK.
OBJECTIVE
To compare the distribution and assess genetic associations of the PTPN22 R620W single-nucleotide polymorphism among South Asian (Asiatic Indian) patients with rheumatoid arthritis (RA) and ethnically matched controls.


METHODS
DNA samples from 133 rheumatoid factor-positive South Asian RA patients and 149 control subjects from the East Midlands of the UK were genotyped for PTPN22 R620W polymorphism. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method.


RESULTS
The PTPN22 *T allele frequency was lower than in the Caucasian populations, but the disease association was significant (odds ratio 5.87, 95% confidence interval 1.68-20.52). Similar association was observed for genotypes containing *T allele.


CONCLUSIONS
Our results suggest that the T variant acts as a susceptibility allele for autoantibody-positive RA among South Asians.
Mastana
Sarabjit
S
Department of Human Sciences, Loughborough University, Loughborough, UK. s.s.mastana@lboro.ac.uk
Gilmour
Ashley
A
Ghelani
Anant
A
Smith
Hannah
H
Samanta
Ash
A
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D001210:Asia, Southeastern / Q000208:ethnology; D044466:Asian People / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*; D006113:United Kingdom
C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22