Ecotoxicological quantitative structure-activity relationships for pharmaceuticals.
This paper examined active pharmaceutical ingredients (APIs) acute ecotoxicological modes of action (MOA). It was concluded that the vast majority of APIs acute MOA was non-specific narcosis as; 85% out of 59 APIs had an excess toxicity ratio <7; 70% of the APIs ecotoxicity was overestimated based on a narcotic model; and the majority of APIs Log EC(50)-Log K (ow )regression slopes (-0.49 to -0.86) were within the range of the universal narcosis slopes. However, hydrophobicity is likely not the proper descriptor for assessment of pharmacodynamic APIs chronic ecotoxicity, to asses this accurately new experimental methods need development.
Sanderson
Hans
H
National Environmental Research Institute, Department of Policy Analysis, Aarhus University, Frederiksborgvej 399, Post Box 358, Roskilde 4000, Denmark. hasa@dmu.dk
Thomsen
Marianne
M
D000818:Animals; D003621:Daphnia; D016208:Databases, Factual; D056890:Eukaryota; D005399:Fishes; D008954:Models, Biological; D004364:Pharmaceutical Preparations; D021281:Quantitative Structure-Activity Relationship; D053608:Stupor / Q000139:chemically induced*; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical