Regulatory T cells--the renaissance of the suppressor T cells.
Immune reactions are stringently regulated and balanced by complex interactions of stimulating and suppressing mechanisms. Dysfunctions of this sophisticated immune regulatory network can lead to a variety of diseases such as autoimmunity, allergy, cancer, and pregnancy disorders. The rediscovery of suppressor T cells a decade ago--now designated as T regulatory cells--set off a huge avalanche of research activities leading to a multitude of preclinical and clinical studies. Herein, we give a comprehensive review about this research on T regulatory cells and the relevance of this suppressive T cell population for the development of innovative immune therapeutic strategies.
Bopp
Tobias
T
Department of Dermatology, Johannes Gutenberg-University, Mainz, Germany.
Jonuleit
Helmut
H
Schmitt
Edgar
E
D000818:Animals; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007239:Infections / Q000276:immunology; D015212:Inflammatory Bowel Diseases / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology; D011247:Pregnancy; D013491:Suppressor Factors, Immunologic; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014181:Transplantation Immunology / Q000276:immunology
D013491:Suppressor Factors, Immunologic