title: Bone ingrowth into a porous coated implant predicted by a mechano-regulatory tissue differentiation algorithm.
abstract: Bone ingrowth into a porous surface is one of the primary methods for fixation of orthopaedic implants. Improved understanding of bone formation and fixation of these devices should improve their performance and longevity. In this study predictions of bone ingrowth into an implant porous coating were investigated using mechano-reculatory models. The mechano-regulatory tissue differentiation algorithm proposed by Lacroix et al., and a modified version that enforces a tissue differentiation pathway by transitioning from differentiation to bone adaptation were investigated. The modified algorithm resulted in nearly the same behavior as the original algorithm when applied to a fracture-healing model. The algorithms were further compared using micromechanical finite element model of a beaded porous scaffold. Predictions of bone and fibrous tissue formation were compared between the two algorithms and to clinically observed phenomena. Under loading conditions corresponding to a press-fit hip stem, the modified algorithm predicted bone ingrowth into approximately 25% of the pore space, which is similar to that reported in experimental studies, while the original algorithm was unstable. When micromotion at the bone-implant interface was simulated, 20 microm of transverse displacement resulted in soft tissue formation at the bone-implant interface and minimal bone ingrowth. In contrast, 10 and 5 microm of micromotion resulted in bone filling 40% of the pore space and a stable interface, again consistent with clinical and experimental observations.
authors: Tissue Mechanics Laboratory, Department of Aerospace and Mechanical Engineering, University of Notre Dame, 376 Fitzpatrick Hall, Notre Dame, IN 46556, USA.
authors: Xiangyi
authors: X
authors: Liu
authors: Glen L
authors: GL
authors: Niebur
mesh_terms: D000465:Algorithms; D000818:Animals; D001846:Bone Development / Q000502:physiology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003198:Computer Simulation; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008954:Models, Biological; D016348:Osseointegration / Q000502:physiology*; D016062:Porosity; D019736:Prostheses and Implants
chemical_list: D020099:Coated Materials, Biocompatible