Association of XPD polymorphisms with prostate cancer in Taiwanese patients.
BACKGROUND
The DNA repair gene XPD, an important caretaker of the overall genome stability, is thought to play a major role in the development of human malignancy. Polymorphic variants of XPD, at codon 312, 751, and other sites, have been associated with cancer susceptibility, but few studies have investigated their effect on prostate cancer risk.


METHODS
In this hospital-based case-control study, the association of XPD codon 312, 751 and promoter-114 polymorphisms with prostate cancer risk in a Taiwanese population were investigated. In total, 123 patients with prostate cancer and 479 healthy controls recruited from the China Medical Hospital in Central Taiwan were genotyped.


RESULTS
We found a significant difference in the frequency of the XPD codon 312 genotype, but not the XPD codon 751 or promoter-114 genotypes, between the prostate cancer and control groups. Those who had GIA or A/A at XPD codon 312 showed a 1.81-fold (95% confidence interval=1.21-2.69) increased risk of prostate cancer compared to those with GIG. As for XPD codon 312 or promoter-114, there was no difference in distribution between the prostate cancer and control groups.


CONCLUSIONS
Our findings suggest that the heterozygous and homozygous A allele of the XPD codon 312 may be associated with the development of prostate cancer and may be a useful marker for primary prevention and anticancer intervention.
Bau
Da-Tian
DT
Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC.
Wu
Hsi-Chin
HC
Chiu
Chang-Fang
CF
Lin
Cheng-Chieh
CC
Hsu
Chin-Moo
CM
Wang
Cheng-Li
CL
Wang
Rou-Fen
RF
Tsai
Fuu-Jen
FJ
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003062:Codon; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
D003062:Codon; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human