title: Modular one-pot synthesis of tetrasubstituted pyrroles from alpha-(alkylideneamino)nitriles.
abstract: 2,3,4,5-Tetrasubstituted pyrroles have been prepared with high regioselectivity by a formal cycloaddition of alpha-(alkylideneamino)nitriles and nitroolefins followed by elimination of HCN and HNO2. The reaction allows the convergent construction of the pyrrole ring in four steps from a nitroalkane and three aldehydes.
authors: Institute of Organic Chemistry, University of Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany.
authors: Ines
authors: I
authors: Bergner
authors: Till
authors: T
authors: Opatz
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D003500:Cyclization; D009570:Nitriles / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis*
chemical_list: D000447:Aldehydes; D000475:Alkenes; D009570:Nitriles; D009574:Nitro Compounds; D011758:Pyrroles