Constrictive bronchiolitis after treatment of colon cancer with 5-fluorouracil.
Constrictive bronchiolitis (CB) is a rare disease with unclear etiology. We report a 37-year-old female with CB who developed progressive dyspnea and cough after completing a course of 5-fluorouracil (5-FU) for colon cancer. The patient had evidence of irreversible obstructive lung disease and lung biopsy showed typical findings of chronic inflammation, submucosal thickening and obliteration of bronchioles. To the best of our knowledge this is the first reported case of CB after treatment with 5-FU.
Valdivia-Arenas
Martin A
MA
Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Ohio State University Medical Center, Columbus, Ohio, USA.
Soriano
Andres O
AO
Arteaga
Roque B
RB
D000328:Adult; D001988:Bronchiolitis / Q000150:complications* / Q000473:pathology*; D003110:Colonic Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D015898:Tomography Scanners, X-Ray Computed
D005472:Fluorouracil