title: Radiation therapy for cutaneous squamous cell carcinoma involving the parotid area lymph nodes: dose and volume considerations.
abstract: OBJECTIVE
  The intraparotid and periparotid lymph nodes are the most commonly involved when skin cancer of the head and neck metastasizes beyond the primary site. We sought to report the clinical outcome of patients treated with radiation therapy for parotid-area metastases from cutaneous squamous cell carcinoma of the head and neck.
  
  
  METHODS
  The records of 36 patients treated with radiation therapy for cutaneous squamous cell carcinoma involving the parotid-area lymph nodes were reviewed. All patients had clinically N0 necks and were without evidence of distant disease. Thirty patients (83%) were treated postoperatively after gross total tumor resection. Median dose to the parotid area was 60 Gy (range, 50-72 Gy). Treatment of clinically N0 necks consisted of surgical dissection (7 patients), irradiation (15 patients), and observation (14 patients).
  
  
  RESULTS
  The 5-year estimate of local (parotid) control was 86% in patients treated using surgery with postoperative therapy and 47% in patients treated using radiation therapy alone. Three of 4 patients with tumors that relapsed locally after surgery and postoperative radiation received a dose of less than 60 Gy. Elective neck irradiation decreased the incidence of subsequent nodal failures from 50% to 0% and significantly improved neck control (p < 0.001). The 5-year overall survival rate was 63%.
  
  
  CONCLUSIONS
  Surgery followed by radiation therapy to doses of at least 60 Gy results in effective local control for patients with parotid area metastasis from cutaneous squamous cell carcinoma. Routine irradiation of the clinically N0 neck is recommended.
authors: Department of Radiation Oncology, University of California, San Francisco, Comprehensive Cancer Center, San Francisco, CA, USA. allenmchen@yahoo.com
authors: Allen M
authors: AM
authors: Chen
authors: Roy C
authors: RC
authors: Grekin
authors: Joaquin
authors: J
authors: Garcia
authors: Mary K
authors: MK
authors: Bucci
authors: Lawrence W
authors: LW
authors: Margolis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland; D010307:Parotid Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D012878:Skin Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D016019:Survival Analysis