title: Bone morphogenetic protein.
abstract: Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor-beta superfamily. It has been demonstrated that BMPs had been involved in the regulation of cell proliferation, survival, differentiation and apoptosis. However, their hallmark ability is that play a pivotal role in inducing bone, cartilage, ligament, and tendon formation at both heterotopic and orthotopic sites. In this review, we mainly concentrate on BMP structure, function, molecular signaling and potential medical application.
authors: College of Life Sciences, Zhejiang University, 310058, China.
authors: Yong-Tao
authors: YT
authors: Xiao
authors: Li-Xin
authors: LX
authors: Xiang
authors: Jian-Zhong
authors: JZ
authors: Shao
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism; D049109:Cell Proliferation; D019281:Dimerization; D006031:Glycosylation; D006801:Humans; D008954:Models, Biological; D008968:Molecular Conformation; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta