title: Diabetes does not influence oral oncogenesis through fibroblast growth factor receptors.
abstract: BACKGROUND
  Increased expression of fibroblast growth factors and their receptors (FGFRs) has recently been described in oral squamous cell carcinoma. In addition, we have previously described a molecular basis for an association between oral cancer and diabetes. The expression of FGFR-2 and FGFR-3 investigated in an experimental model of chemically induced carcinogenesis in normal and diabetic (type I) rats.
  
  
  METHODS
  Tissue sections ranging from normal mucosa to moderately-differentiated oral squamous cell carcinoma were studied using monoclonal antibodies against FGFR-2 and FGFR-3 proteins.
  
  
  RESULTS
  A similar pattern of elevated FGFR-2 and FGFR-3 expression was observed in the initial stages of oncogenesis for both diabetic and non-diabetic animals. In the last stages of oral oncogenesis, the expression of both proteins remained relatively stable.
  
  
  CONCLUSIONS
  It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis.
authors: Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Athens, Greece. lvairakt@med.uoa.gr
authors: Eleftherios
authors: E
authors: Vairaktaris
authors: Lambros
authors: L
authors: Goutzanis
authors: Emeka
authors: E
authors: Nkenke
authors: Sofia
authors: S
authors: Spyridonidou
authors: Stavros
authors: S
authors: Vassiliou
authors: Spyridoula
authors: S
authors: Derka
authors: Antonis
authors: A
authors: Vylliotis
authors: Christos
authors: C
authors: Yapijakis
authors: Andreas
authors: A
authors: Lazaris
authors: Pashalis
authors: P
authors: Strantzias
authors: Eleftherios
authors: E
authors: Kalimeras
authors: Efstratios
authors: E
authors: Patsouris
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000276:immunology / Q000378:metabolism*; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000276:immunology / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; C069820:Fgfr3 protein, rat; C496356:Fgfr2 protein, rat; D051497:Receptor, Fibroblast Growth Factor, Type 2; D051498:Receptor, Fibroblast Growth Factor, Type 3