title: Effect of a lipid-enriched diet on body composition and some regulatory hormones of food intake in growing rats.
abstract: OBJECTIVE
  The aim of the present study was to investigate the effects of a lipid-enriched diet on body composition and on main regulatory hormones of food intake (insulin, adiponectin, leptin, ghrelin).
  
  
  METHODS
  Two groups of 16 rats, 35 days old, weighing 80+/-6 g, were constituted. One group (S) was given a standard diet during 10 weeks and served as control. The second group (L) was given a lipidic-enriched diet (containing: G: 41.5, L: 38.5, P: 20% calorie). Food and water were given "ad libitum".
  
  
  RESULTS
  Total food intake, body weight, skeletal area and lean body mass of rats eating lipid-enriched diet were lowered (6694+/-178 vs. 8160+/-184 kcal, P=0.01; 431+/-38 vs. 468+/-25 g, P=0.003; 72.19+/-0.96 vs. 76.07+/-1.31 cm2, P=0.03; 369+/-18 vs. 409+/-23 g, P=0.0006), fat mass difference was not statistically significant (82.5+/-17 vs. 80+/-17 g, P=0.7). Blood ghrelin, adiponectin levels were lowered (1517+/-224 vs. 1915+/-579 pg/ml, P=0.03; 10+/-3 vs. 19+/-3 microg/ml, P=0.003) whereas insulin and leptin were unchanged (1.8+/-1.5 vs. 2.6+/-1.4 ng/ml, P=0.1; 16+/-11 vs. 13+/-10 ng/ml, P=0.4).
  
  
  CONCLUSIONS
  A period of high fat diet in growing rats leads to a hypophagia, resulting in a lower lean body mass development. Some regulatory hormones of food intake did not change, while others significantly decreased, notably ghrelin being possible causal factor of the observed hypophagia linked to high fat diet.
authors: Service de biologie des activités physiques et sportives (BAPS), laboratoire de biologie B, Les Cézeaux, 63177 Aubière cedex, France.
authors: E
authors: E
authors: Ebal
authors: H
authors: H
authors: Cavalié
authors: O
authors: O
authors: Michaux
authors: G
authors: G
authors: Lac
mesh_terms: D052242:Adiponectin / Q000097:blood; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D004041:Dietary Fats / Q000494:pharmacology*; D002149:Energy Intake; D004734:Energy Metabolism / Q000187:drug effects; D054439:Ghrelin / Q000097:blood; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D052242:Adiponectin; D004041:Dietary Fats; D054439:Ghrelin; D007328:Insulin; D020738:Leptin