Homovanillic acid (HVA) plasma levels inversely correlate with attention deficit-hyperactivity and childhood neglect measures in addicted patients.
BACKGROUND
Attention deficit hyperactivity disorder (ADHD) seems to be a risk condition for substance use disorders, possibly in relationship to common neurobiological changes, underlying both addictive and externalising behaviour susceptibility. Although this vulnerability has been primarily attributed to gene variants, previous studies suggest that also adverse childhood experiences may influence neurotransmission, affecting in particular brain dopamine (DA) system and possibly concurring to the development of behavioural disorders. Therefore, we decided to investigate ADHD symptoms and plasma concentrations of the DA metabolite homovanillic acid (HVA) in abstinent addicted patients, in comparison with healthy control subjects, evaluating whether ADHD scores were related with HVA levels, as expression of DA turnover, and whether HVA values, in turn, were associated with childhood emotional neglect.


METHODS
Eighty-two abstinent drug dependent patients, and 44 normal controls, matched for age and sex, completed the Wender Utah Rating Scale (WURS), measuring ADHD symptoms, and the Childhood Experience of Care and Abuse Questionnaire (CECA-Q). Blood samples were collected to determine HVA plasma levels.


RESULTS
Addicted individuals showed significantly higher ADHD scores and lower HVA levels respect to control subjects. ADHD scores at WURS in addicted patients negatively correlated with plasma HVA values. In turn, plasma HVA levels were inversely associated with childhood neglect measures, reaching statistical significance with "mother-antipathy" and "mother neglect" scores.


CONCLUSIONS
These findings suggest the possibility that childhood experience of neglect and poor mother-child attachment may have an effect on central dopamine function as an adult, in turn contributing to both ADHD and substance abuse neurobiological vulnerability.
Gerra
G
G
Servizio Tossicodipendenze, AUSL Parma, Parma, Italy. gilberto.gerra@unodc.org
Leonardi
C
C
Cortese
E
E
Zaimovic
A
A
Dell'agnello
G
G
Manfredini
M
M
Somaini
L
L
Petracca
F
F
Caretti
V
V
Saracino
M A
MA
Raggi
M A
MA
Donnini
C
C
D000328:Adult; D000987:Antisocial Personality Disorder / Q000453:epidemiology; D001007:Anxiety / Q000150:complications; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood* / Q000453:epidemiology* / Q000523:psychology; D002648:Child; D002649:Child Abuse / Q000523:psychology; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000453:epidemiology; D005260:Female; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D008297:Male; D019966:Substance-Related Disorders / Q000097:blood* / Q000453:epidemiology* / Q000523:psychology
D006719:Homovanillic Acid
Ann N Y Acad Sci. 2001 Jun;931:33-49
11462751
Psychopharmacol Bull. 1985;21(2):178-91
2860690
Pharmacol Rev. 2005 Mar;57(1):1-26
15734726
Arch Gen Psychiatry. 1993 Jul;50(7):565-76
8317950
Br J Psychiatry. 2007 Jan;190:1-3
17197648
J Am Acad Child Adolesc Psychiatry. 1993 Mar;32(2):324-32
8444761
Am J Psychiatry. 1993 Jun;150(6):885-90
8494063
Psychiatry Res. 1994 Jun;52(3):305-16
7527565
J Int Neuropsychol Soc. 2006 May;12(3):405-15
16903133
Br J Clin Psychol. 2005 Nov;44(Pt 4):563-81
16368034
Neuropsychobiology. 1993;28(1-2):76-81
8255414
Arch Gen Psychiatry. 1996 Jun;53(6):523-9
8639035
Child Adolesc Psychiatr Clin N Am. 2000 Jul;9(3):711-26
10944664
Lancet. 1999 Dec 18-25;354(9196):2132-3
10609822
Arch Gen Psychiatry. 1985 Oct;42(10):937-47
4037987
Z Kinder Jugendpsychiatr Psychother. 2006 Nov;34(6):425-33
17094061
Neuropsychopharmacology. 1996 Feb;14(2):125-37
8822535
Eur Arch Psychiatry Clin Neurosci. 2002 Jun;252(3):130-4
12192471
Am J Med Genet. 2002 Mar 8;114(2):144-9
11857574
J Psychoactive Drugs. 2000 Nov;32 Suppl:i-iv, 1-112
11280926
J Clin Psychiatry. 2006;67 Suppl 8:13-20
16961425
Psychopharmacol Bull. 1995;31(2):425-33
7491401
J Clin Psychiatry. 2004 Oct;65(10):1301-13
15491232
Psychiatr Prax. 2003 May;30(4):182-6
12768521
Psychiatry Res. 1984 Jan;11(1):71-8
6200893
Subst Use Misuse. 2004 Jan;39(2):345-67
15061565
J Child Psychol Psychiatry. 2005 Jul;46(7):774-803
15972070
Alcohol. 2001 Feb;23(2):117-22
11331109
Alcohol Clin Exp Res. 1992 Dec;16(6):1047-51
1335220
Am J Psychiatry. 1997 Jan;154(1):50-5
8988958
J Am Acad Child Adolesc Psychiatry. 1997 Sep;36(9):1222-7
9291723
J Neurosci. 2001 Jan 15;21(2):RC121
11160455
Biol Psychiatry. 2007 Jun 15;61(12):1395-401
17046725
Eur Neuropsychopharmacol. 1999 Jan;9(1-2):141-7
10082240
Prog Brain Res. 2000;126:325-41
11105655
Am J Psychiatry. 2002 Jun;159(6):1053-5
12042199
J Child Psychol Psychiatry. 2006 Nov;47(11):1152-8
17076754
Neuropsychopharmacology. 2001 May;24(5):561-7
11282256
J Subst Abuse. 2000;11(4):337-54
11147231
Neuropsychopharmacology. 2003 May;28(5):1004-10
12741370
Am J Psychiatry. 1995 Dec;152(12):1819-20
8526255
Am J Psychiatry. 1998 Apr;155(4):493-8
9545994
J Abnorm Child Psychol. 1995 Dec;23(6):729-49
8609310
Encephale. 2005 Jul-Aug;31(4 Pt 1):437-47
16389711
EMBO J. 2007 Apr 18;26(8):2127-36
17380124
Am J Psychiatry. 2005 May;162(5):906-13
15863792
J Pers Disord. 1997 Fall;11(3):279-84
9348491
J Pharm Biomed Anal. 2006 Sep 11;42(1):107-12
16406455
J Neural Transm (Vienna). 2005 Oct;112(10):1397-410
15666036
Psychopathology. 2006;39(1):25-31
16282716
Psychiatry Res. 2004 Jul 15;127(3):185-93
15296818
J Am Acad Child Adolesc Psychiatry. 2006 Aug;45(8):973-81
16865040
J Pediatr. 2003 Jul;143(1):104-10
12915833
J Am Acad Child Adolesc Psychiatry. 1996 Mar;35(3):343-51
8714323
Encephale. 1999 Nov-Dec;25(6):569-75
10668599
Biol Psychiatry. 2000 Mar 1;47(5):428-33
10704954
Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jul;18(4):741-52
7524113
Cereb Cortex. 2000 Mar;10(3):318-25
10731226
J Dev Behav Pediatr. 2004 Dec;25(6):383-91
15613986
Am J Addict. 1998 Spring;7(2):156-63
9598219
Compr Psychiatry. 1993 Mar-Apr;34(2):75-82
8485984
J Am Acad Child Adolesc Psychiatry. 1995 May;34(5):658-69
7775361
Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):49-53
17579368
J Neural Transm (Vienna). 2007;114(5):607-12
17347774
Biol Psychiatry. 1989 Aug;26(4):356-62
2765598
Am J Psychiatry. 2006 Jul;163(7):1239-44
16816230
J Addict Dis. 2004;23(4):31-40
15339712
J Am Acad Child Adolesc Psychiatry. 2000 Dec;39(12):1537-42
11128331
Am J Psychiatry. 1999 Jan;156(1):130-2
9892309
Psychopharmacology (Berl). 2006 Jun;186(2):185-90
16703401
Pharmacogenet Genomics. 2006 Jan;16(1):25-36
16344719
Mod Probl Pharmacopsychiatry. 1990;24:124-51
1970851
Psychiatry Clin Neurosci. 2005 Jun;59(3):311-8
15896225
Lancet. 2000 Apr 22;355(9213):1461; author reply 1461-2
10791548
Life Sci. 1998;62(7):617-25
9472721
Am J Med Genet B Neuropsychiatr Genet. 2003 Jan 1;116B(1):103-25
12497624
Psychol Med. 2007 Dec;37(12):1681-92
17506925
Psychiatry Res. 1996 Jun 1;62(3):203-11
8804130
Curr Psychiatry Rep. 2001 Apr;3(2):92-100
11276403
J Clin Psychiatry. 2000 Apr;61(4):244-51
10830144
World J Biol Psychiatry. 2002 Apr;3(2):96-100
12479082
Annu Rev Psychol. 2000;51:1-27
10751963
Drug Alcohol Depend. 2007 Mar 16;87(2-3):233-40
16997508
Am J Psychiatry. 2001 Dec;158(12 ):2015-21
11729018
Neuropsychopharmacology. 2003 Sep;28(9):1712-9
12825091
Am J Med Genet. 1999 Aug 20;88(4):358-68
10402503
Arch Gen Psychiatry. 1996 May;53(5):437-46
8624187
Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):100-6
17579349
J Subst Abuse. 1995;7(3):373-8
8749796
Neurosci Biobehav Rev. 2000 Jan;24(1):21-5
10654656
Neuropsychobiology. 1994;30(1):15-9
7969853
Neuropharmacology. 2004;47 Suppl 1:227-41
15464140
CMAJ. 2003 Mar 18;168(6):715-22
12642429
Addict Biol. 2003 Mar;8(1):23-32
12745412
J Am Acad Child Adolesc Psychiatry. 1998 Jul;37(7):718-27
9666627
Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4552-7
16537431