Homocysteine serum concentration and uterine artery color Doppler examination in cases of recurrent miscarriages with unexplained etiology.
OBJECTIVE
To study the assessment of diagnostic value and clinical usefulness of the determination of homocysteine concentration in blood serum in cases of recurrent miscarriages and the relation between the concentration of homocysteine in blood serum and parameter values determining the Doppler blood flow in the uterine arteries.


METHODS
Homocysteine concentration in blood serum was determined in a group of 30 women with at least two subsequent miscarriages with no clear reason and in the control group consisted of 20 non-pregnant women without a medical history of obstetric failures, having at least one healthy child. In all cases Color Doppler sonography was performed to determine flow velocity waveforms of the uterine arteries in luteal phase of the menstrual cycle.


RESULTS
Both pulsatility (PI) and resistance indices (RI) were considerably higher (p<0.01, p<0.05) for the group of women with recurrent abortions. In the group of women with obstetrical failures high positive correlation (R=0.6903, p<0.001) and in the control group very high positive correlation (r=0.8163, p<0.001) was found, between average values of PI and average HC concentration. High positive correlation (R=0.6260, p<0.001) in the examined group and very high positive correlation (r=0.9201, p<0.001) in the control group was obtained between average values of RI, and average HC concentrations in blood serum .


CONCLUSIONS
The recurring miscarriages occur in connection with the elevated homocysteine concentration, in consequence they can point out the pathology within the uterine-fetal blood vessels.
Sikora
Jerzy
J
Department of Obstetrics and Gynecology, Silesian Medical University, ul. Medyków 14, 40-752 Katowice, Poland. jerzy_sikora@poczta.onet.pl
Magnucki
Jacek
J
Zietek
Jerzy
J
Kobielska
Lucyna
L
Partyka
Robert
R
Kokocinska
Danuta
D
Białas
Aleksandra
A
D000026:Abortion, Habitual / Q000097:blood* / Q000209:etiology / Q000503:physiopathology*; D000328:Adult; D001158:Arteries / Q000000981:diagnostic imaging / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology; D016022:Case-Control Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D012039:Regional Blood Flow / Q000502:physiology; D018615:Ultrasonography, Doppler, Color; D014599:Uterus / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000502:physiology*; D014655:Vascular Resistance / Q000502:physiology
D006710:Homocysteine