Effect of vitamin E on oxidative stress status in small intestine of diabetic rat.
OBJECTIVE
To investigate the effect of vitamin E on oxidative stress status in the small intestine of diabetic rats.


METHODS
Twenty-four male Wistar rats were randomly divided into three groups: Control (C), non-treated diabetic (NTD) and vitamin E-treated diabetic (V(E)TD) groups. The increases in lipid peroxidation, protein oxidation and superoxide dismutase (SOD) in these three groups was compared after 6 wk.


RESULTS
There was no significant difference in catalase activity between NTD and control rats. Compared to NTD rats, the treatment with vitamin E significantly decreased lipid peroxidation and protein oxidation, and also increased catalase activity and SOD.


CONCLUSIONS
The results revealed the occurrence of oxidative stress in the small intestine of diabetic rats. Vitamin E, as an antioxidant, attenuates lipid peroxidation and protein oxidation, and increases antioxidant defense mechanism.
Shirpoor
A
A
Department of Physiology, Faculty of Medicine, Jaddeh Nazloo, Urmia, Iran. ashirpoor@yahoo.com
Ansari
M-H-Khadem
MH
Salami
S
S
Pakdel
F-Ghaderi
FG
Rasmi
Y
Y
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D007421:Intestine, Small / Q000187:drug effects / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D014810:Vitamin E; D013311:Streptozocin; D002374:Catalase; D013482:Superoxide Dismutase
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