title: [Recombinant factor VIII-CVP therapy for acquired factor VIII inhibitors].
abstract: A 78-year-old man and an 81-year-old woman without hemophilia suddenly developed giant ecchymoses and intramuscular hemorrhage. Prolonged activated partial thromboplastin time and low factor VIII activity were observed, and the patients were subsequently diagnosed as having acquired factor VIII inhibitors. The patients were infused with one dose of recombinant factor VIII, 50 to 100 U/kg body weight, followed by cyclophosphamide, 500 mg on day 1 and 200 mg/day on days 2 to 5; vincristine, 2 mg on day 1; and prednisolone, 100 mg/day on days 1 to 5 (recombinant factor VIII-CVP therapy). Both patients responded after one course of therapy. Disappearance of inhibitors was achieved after three to four courses of therapy without subsequent recurrence. Recombinant factor VIII-CVP therapy is safe and effective in the eradication of factor VIII inhibitors.
authors: Department of Hematology, Tokyo Women's Medical University, School of Medicine.
authors: Naoki
authors: N
authors: Mori
authors: Kaoru
authors: K
authors: Toyokawa
authors: Masanao
authors: M
authors: Teramura
authors: Michihiko
authors: M
authors: Masuda
authors: Toshiko
authors: T
authors: Motoji
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000628:therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005169:Factor VIII / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D006474:Hemorrhagic Disorders / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; C078147:F8 protein, human; D003520:Cyclophosphamide; D005169:Factor VIII; D011241:Prednisone