title: [Pilot study of a cell membrane like biomimetic drug-eluting coronary stent].
abstract: A novel bioinspired phospholipid copolymer has been synthesized by the radical polymerization of poly2-Methacryloyloxyethylphosphorylcholine (MPC), stearyl methacrylate (SMA), hydroxypropyl methacrylate (HPMA) and trimethoxysilylpropyl methacrylate (TSMA). Contact angle results indicated that the coating surface rearranged to get a more hydrophilic surface at the polymer/water interface. The membrane mimic phosphorylcholine coating surface could resist the platelet adhesion and prolong plasma recalcification time significantly. Rapamycin was used as model drugs to prepare drug-eluting coating. The animal experiments showed that this novel drug-eluting stent could effectively prevent the phenomena of restenosis.
authors: Advanced Technology & Materials Co., Ltd, Beijing 100081, China. fandezeng@aqtmcn.com
authors: Dezeng
authors: D
authors: Fan
authors: Zhiyuan
authors: Z
authors: Jia
authors: Xinhao
authors: X
authors: Yan
authors: Xiaolei
authors: X
authors: Liu
authors: Wei
authors: W
authors: Dong
authors: Fuyu
authors: F
authors: Sun
authors: Jian
authors: J
authors: Ji
authors: Jianping
authors: J
authors: Xu
authors: Kefeng
authors: K
authors: Ren
authors: Weidong
authors: W
authors: Chen
authors: Jiacong
authors: J
authors: Shen
authors: Hong
authors: H
authors: Qiu
authors: Runlin
authors: R
authors: Gao
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D000818:Animals; D020099:Coated Materials, Biocompatible; D023903:Coronary Restenosis / Q000517:prevention & control*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D010865:Pilot Projects; D011108:Polymers / Q000737:chemistry; D011474:Prosthesis Design; D011897:Random Allocation; D020123:Sirolimus / Q000737:chemistry; D013552:Swine; D013556:Swine, Miniature
chemical_list: D020099:Coated Materials, Biocompatible; D008689:Methacrylates; D011108:Polymers; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine; C032802:hydroxypropyl methacrylate; D020123:Sirolimus