Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats.
Impaired onset of maternal behavior in first generation rat dams was previously correlated with rearing by cocaine-treated dams and prenatal cocaine exposure. Pup-induced maternal behavior in non-lactating rats has not been examined with regard to cocaine exposure and rearing conditions. First generation male and female juveniles and young adult males reared by cocaine-treated or control dams and prenatally exposed to either cocaine or control conditions were tested for pup-induced maternal behavior at postnatal days 28 and 60. We now report disruptions in pup-induced maternal behavior in both 28 and 60 day old first generation offspring attributable to rearing condition and prenatal cocaine exposure.
Johns
Josephine M
JM
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7096, USA. jjohns@med.unc.edu
McMurray
Matthew S
MS
Hofler
Vivian E
VE
Jarrett
Thomas M
TM
Middleton
Christopher L
CL
Elliott
Deborah L
DL
Mirza
Raessa
R
Haslup
Amber
A
Elliott
Jay C
JC
Walker
Cheryl H
CH
D000375:Aging; D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000633:toxicity*; D005260:Female; D008297:Male; D008425:Maternal Behavior / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000779:Anesthetics, Local; D003042:Cocaine
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