title: FDG-PET in T-cell and NK-cell neoplasms.
abstract: BACKGROUND
  A growing number of studies demonstrate the utility of (18)fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in the management of malignant lymphoma. The results of FDG-PET, however, have not been studied extensively for T-cell and natural killer (NK)-cell neoplasms.
  
  
  METHODS
  We retrospectively evaluated pretreatment FDG-PET scans in 41 patients with T/NK-cell neoplasms diagnosed according to the World Health Organization (WHO) classification. Histological subtypes frequently included were peripheral T-cell lymphoma, unspecified (PTCLu, n = 11), extranodal NK/T-cell lymphoma, nasal type (ENKL, n = 8), primary cutaneous anaplastic large cell lymphoma (C-ALCL, n = 5), and angioimmunoblastic T-cell lymphoma (AILT, n = 4).
  
  
  RESULTS
  FDG-PET detected a lymphoma lesion in at least one site in 36 out of 41 patients. The positive rate was equally high in most histological subtypes except for cutaneous lymphomas: PTCLu 91%, ENKL 100%, C-ALCL 60%, AILT 100%. All the patients without an FDG-avid lesion had lesions restricted to skin. Among patients who had cutaneous lesions, only 50% had FDG-avid cutaneous lesions, all of which were tumorous. The positive rate of FDG-PET for bone marrow involvement was only 20%.
  
  
  CONCLUSIONS
  T/NK-cell neoplasms incorporated in this study were generally FDG-avid except for cutaneous lesions and bone marrow involvement.
authors: Department of Hematology & Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors: S
authors: S
authors: Kako
authors: K
authors: K
authors: Izutsu
authors: Y
authors: Y
authors: Ota
authors: Y
authors: Y
authors: Minatani
authors: M
authors: M
authors: Sugaya
authors: T
authors: T
authors: Momose
authors: K
authors: K
authors: Ohtomo
authors: Y
authors: Y
authors: Kanda
authors: S
authors: S
authors: Chiba
authors: T
authors: T
authors: Motokura
authors: M
authors: M
authors: Kurokawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000000981:diagnostic imaging*; D016399:Lymphoma, T-Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D019788:Fluorodeoxyglucose F18