title: The origin of trisomy 22: evidence for acrocentric chromosome-specific patterns of nondisjunction.
abstract: Trisomy 22 is one of the most common trisomies in clinically recognized pregnancies, yet relatively little is known about the origin of nondisjunction for chromosome 22. Accordingly, we initiated studies to investigate the origin of the extra chromosome in 130 trisomy 22 cases. Our results indicate that the majority of trisomy 22 errors (>96%) arise during oogenesis with most of these errors ( approximately 90%) occurring during the first meiotic division. As with other trisomies, failure to recombine contributed to nondisjunction of chromosome 22. Taken together with data available for other trisomies, our results suggest patterns of nondisjunction that are shared among the acrocentric, but not all nonacrocentric, chromosomes.
authors: Center for Reproductive Biology and School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4660, USA.
authors: Heather E
authors: HE
authors: Hall
authors: Urvashi
authors: U
authors: Surti
authors: Lori
authors: L
authors: Hoffner
authors: Sofia
authors: S
authors: Shirley
authors: Eleanor
authors: E
authors: Feingold
authors: Terry
authors: T
authors: Hassold
mesh_terms: D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D005333:Fetus; D006801:Humans; D008540:Meiosis; D009630:Nondisjunction, Genetic; D011995:Recombination, Genetic; D014314:Trisomy