title: Influence of inoculum size on the selection of resistant mutants of Escherichia coli in relation to mutant prevention concentrations of marbofloxacin.
abstract: We demonstrate using an in vitro pharmacodynamic model that the likelihood of selection of Escherichia coli mutants resistant to a fluoroquinolone was increased when the initial size of the bacterial population, exposed to fluoroquinolone concentrations within the mutant selection window, was increased.
authors: UMR181 Physiopathologie et Toxicologie Expérimentales, INRA, ENVT, Ecole Nationale Vétérinaire de Toulouse, 23 chemin des Capelles, BP 87 614, 31076 Toulouse Cedex 3, France.
authors: Aude
authors: A
authors: Ferran
authors: Véronique
authors: V
authors: Dupouy
authors: Pierre-Louis
authors: PL
authors: Toutain
authors: Alain
authors: A
authors: Bousquet-Mélou
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development; D024841:Fluoroquinolones / Q000493:pharmacokinetics / Q000494:pharmacology*; D050296:Microbial Viability / Q000187:drug effects / Q000235:genetics; D009154:Mutation; D015363:Quinolones / Q000493:pharmacokinetics / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D015363:Quinolones; C080260:marbofloxacin
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