title: An agent-based multilayer architecture for bioinformatics grids.
abstract: Due to the huge volume and complexity of biological data available today, a fundamental component of biomedical research is now in silico analysis. This includes modelling and simulation of biological systems and processes, as well as automated bioinformatics analysis of high-throughput data. The quest for bioinformatics resources (including databases, tools, and knowledge) becomes therefore of extreme importance. Bioinformatics itself is in rapid evolution and dedicated Grid cyberinfrastructures already offer easier access and sharing of resources. Furthermore, the concept of the Grid is progressively interleaving with those of Web Services, semantics, and software agents. Agent-based systems can play a key role in learning, planning, interaction, and coordination. Agents constitute also a natural paradigm to engineer simulations of complex systems like the molecular ones. We present here an agent-based, multilayer architecture for bioinformatics Grids. It is intended to support both the execution of complex in silico experiments and the simulation of biological systems. In the architecture a pivotal role is assigned to an "alive" semantic index of resources, which is also expected to facilitate users' awareness of the bioinformatics domain.
authors: Department of Mathematics and Computer Science, University of Camerino, 1-62032 Camerino, Italy.
authors: Ezio
authors: E
authors: Bartocci
authors: Diletta
authors: D
authors: Cacciagrano
authors: Nicola
authors: N
authors: Cannata
authors: Flavio
authors: F
authors: Corradini
authors: Emanuela
authors: E
authors: Merelli
authors: Luciano
authors: L
authors: Milanesi
authors: Paolo
authors: P
authors: Romano
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003628:Database Management Systems; D016208:Databases, Factual; D016247:Information Storage and Retrieval / Q000379:methods*; D020407:Internet; D008967:Molecular Biology / Q000379:methods*; D014584:User-Computer Interface