Influence of inoculum size on the selection of resistant mutants of Escherichia coli in relation to mutant prevention concentrations of marbofloxacin.
We demonstrate using an in vitro pharmacodynamic model that the likelihood of selection of Escherichia coli mutants resistant to a fluoroquinolone was increased when the initial size of the bacterial population, exposed to fluoroquinolone concentrations within the mutant selection window, was increased.
Ferran
Aude
A
UMR181 Physiopathologie et Toxicologie Expérimentales, INRA, ENVT, Ecole Nationale Vétérinaire de Toulouse, 23 chemin des Capelles, BP 87 614, 31076 Toulouse Cedex 3, France.
Dupouy
Véronique
V
Toutain
Pierre-Louis
PL
Bousquet-Mélou
Alain
A
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development; D024841:Fluoroquinolones / Q000493:pharmacokinetics / Q000494:pharmacology*; D050296:Microbial Viability / Q000187:drug effects / Q000235:genetics; D009154:Mutation; D015363:Quinolones / Q000493:pharmacokinetics / Q000494:pharmacology*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D015363:Quinolones; C080260:marbofloxacin
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