Evaluation of change in CD4+ cell counts in AIDS clinical trials.
To evaluate the antiretroviral activity of antiretroviral agents and to compare the effects of two different antiretroviral agents, we propose a non-parametric mixed-effects model to investigate change of CD4+ counts. The proposed model and methods are applied to analyse the data from PACTG345 study. Population and individual patterns of change of CD4+ counts and a reference band are obtained. Our results indicate that treatment with high-dose ritonavir is significantly superior compared with low-dose ritonavir.
Liang
H
H
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA. hliang@bst.rochester.edu
D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D019438:Ritonavir / Q000008:administration & dosage / Q000627:therapeutic use*
D017320:HIV Protease Inhibitors; D019438:Ritonavir
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