title: Peripheral neuropathy related to chemotherapy.
abstract: OBJECTIVE
  To review the evidence base for prevention and intervention of chemotherapy-induced peripheral neuropathy (PN).
  
  
  METHODS
  Medical and nursing literature.
  
  
  CONCLUSIONS
  Many small studies that reported positive findings have either not been validated in large prospective, randomized controlled trials (RCT), or have not been further studied. Prevention strategies based on RCTs include the use of xaliproden to reduce the incidence of grade 3 PN in patients receiving oxaliplatin-based regimens, and dose reduction or interruption until recovery. There are gaps in the literature of nurse-sensitive outcome studies for nursing assessment and intervention
  
  
  CONCLUSIONS
  Nurses need to be knowledgeable about the evidence, or lack of it, on strategies to prevent and manage chemotherapy-induced PN. Nurses also need to measure the effectiveness of interventions for PN, such as exercise, patient teaching about self-care strategies, and develop and/or participate in well-designed intervention studies regarding the prevention and management of PN.
authors: Boston Medical Center, MA, USA. gwilkes@comcast.net
authors: Gail
authors: G
authors: Wilkes
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000451:nursing / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents