Granulocytic sarcoma involving the uterus and right fallopian tube with negative endometrial biopsy.
Granulocytic sarcoma is an extramedullary tumor associated with acute myelogenous leukemia (AML) and it is rarely seen in the female genital tract. We report an unusual case of granulocytic sarcoma of the uterus and fallopian tube in an AML patient who presented with vaginal bleeding and persistent abdominal pain. She was under chemotherapy. Biopsy did not reveal the diagnosis. After laparoscopic examination, hysterectomy with bilateral salpingo-oophorectomy was performed. Pathology showed atypical myeloid cells infiltrating the muscle bundles which was consistent with granulocytic sarcoma involving the uterus and right fallopian tube. Immunohistochemistry confirmed the diagnosis. The patient is in complete remission for AML and being followed-up for granulocytic sarcoma. Granulocytic sarcoma of the uterus and fallopian tube is very rare, and in AML patients with abnormal uterine bleeding but negative endometrial biopsy it should still be considered in the differential diagnosis.
Kilic
G
G
Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center Houston, Texas, USA.
Boruban
M C
MC
Bueco-Ramos
C
C
Konoplev
S N
SN
D005185:Fallopian Tube Neoplasms / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008796:Metrorrhagia / Q000209:etiology; D008875:Middle Aged; D017699:Pelvic Pain / Q000209:etiology; D023981:Sarcoma, Myeloid / Q000150:complications / Q000473:pathology*; D014594:Uterine Neoplasms / Q000150:complications / Q000473:pathology*