title: The role of pelvic exenteration and reconstruction for treatment of advanced or recurrent gynecologic malignancies: Analysis of risk factors predicting recurrence and survival.
abstract: OBJECTIVE
  Pelvic exenteration offers the last chance of cure for some advanced or recurrent gynecologic malignancy patients. The aim of this prospective study was to analyze factors associated with recurrence and survival after pelvic exenteration.
  
  
  METHODS
  Forty-six women with advanced or recurrent gynecologic malignancies were enrolled between July 2001 and February 2006. All pelvic exenteration surgery was performed by the same gynecological oncologist.
  
  
  RESULTS
  Two patients were excluded due to the discovery of peritoneal disease during surgery. Multivariate analysis showed that a tumor size >4 cm was the only factor associated with risk of recurrence after surgery (P = 0.014), that margin status was the only factor associated with disease-free survival (P = 0.0.047), and that margin status and lymph node metastasis were associated with overall survival (P = 0.017 and 0.012, respectively).
  
  
  CONCLUSIONS
  Pelvic exenteration and reconstruction was found to have a potential to provide long-term survival without postoperative mortality although the morbidity rate is somewhat high. Multivariate analysis showed that tumor size >4 cm was a predictive factor for recurrence, and that margin status and lymph node metastasis were predictive factors for survival.
authors: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea. catgut1-0@hanmail.net
authors: Jeong-Yeol
authors: JY
authors: Park
authors: Hyuck Jae
authors: HJ
authors: Choi
authors: Seung-Yong
authors: SY
authors: Jeong
authors: Jinsoo
authors: J
authors: Chung
authors: Jung Kun
authors: JK
authors: Park
authors: Sang-Yoon
authors: SY
authors: Park
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005833:Genital Neoplasms, Female / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000601:surgery*; D010385:Pelvic Exenteration; D011446:Prospective Studies; D019651:Plastic Surgery Procedures; D012307:Risk Factors