Comparison of DNA replication in Xenopus laevis and Simian Virus 40.
DNA replication is a fundamental process within the cell cycle. The exact duplication of the genetic information ensures genome stability. Extensive research has identified the principal players required for the sequential processes: origin-licensing (a controlled order of events giving a chromosome site the potential to be initiated within the S phase of the same cell cycle); initiation (by removing the license a previous licensed site is transformed into a site where the DNA helix starts to melt); and DNA replication (copying the parental DNA by leading and lagging strand DNA-synthesis). The present report compares the advantages and limitations of studying DNA replication in the model systems Xenopus laevis (X. laevis) and in Simian Virus 40 (SV40).
Oehlmann
Maren
M
Department of Biochemistry, National University of Ireland, Galway, Ireland. maren.oehlmann@nuigalway.ie
Mahon
Cathal
C
Nasheuer
Heinz-Peter
HP
D000818:Animals; D001665:Binding Sites; D002453:Cell Cycle; D004247:DNA / Q000737:chemistry; D004261:DNA Replication; D006801:Humans; D051738:Origin Recognition Complex; D018741:Replication Origin; D016196:S Phase; D013539:Simian virus 40 / Q000378:metabolism*; D013045:Species Specificity; D014982:Xenopus laevis / Q000378:metabolism*
D051738:Origin Recognition Complex; D004247:DNA