title: Melkersson-Rosenthal syndrome: a form of pseudoangioedema.
abstract: BACKGROUND
  Melkersson-Rosenthal syndrome is an unusual cause of facial swelling that can be confused with angioedema.
  
  
  OBJECTIVE
  To describe a young woman with facial swelling initially considered to be angioedema.
  
  
  METHODS
  A biopsy specimen of the eyelid demonstrated findings consistent with Melkersson-Rosenthal syndrome.
  
  
  RESULTS
  After reviewing the differential diagnosis of pseudoangioedema, a presumptive diagnosis of Melkersson-Rosenthal syndrome was made. The patient was successfully treated with infliximab for Melkersson-Rosenthal syndrome. Owing to medication adverse effects, infliximab treatment was discontinued. Treatment was then continued with adalimumab, with good effect and without adverse events.
  
  
  CONCLUSIONS
  We report the case of a patient with Melkersson-Rosenthal syndrome presenting as angioedema. Furthermore, we report the first successful treatment of Melkersson-Rosenthal syndrome with adalimumab.
authors: Department of Dermatology, Naval Medical Center San Diego, San Diego, California, USA.
authors: Charlene
authors: C
authors: Kakimoto
authors: Chad
authors: C
authors: Sparks
authors: Andrew A
authors: AA
authors: White
mesh_terms: D000068879:Adalimumab; D000328:Adult; D000799:Angioedema / Q000175:diagnosis*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D001706:Biopsy; D003937:Diagnosis, Differential; D005143:Eyelids / Q000473:pathology; D005260:Female; D006801:Humans; D008556:Melkersson-Rosenthal Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000068879:Adalimumab