Guanine binding to dirhodium tetracarboxylate anticancer complexes: quantum chemical calculations unravel an elusive mechanism.
The reaction mechanism leading to metalated DNA fragments in which guanine-N7,O6 spans the metal-metal bond of dirhodium antitumour complexes in a bridging fashion at equatorial sites has been unravelled by a comprehensive prediction of intermediates and transition states.
Deubel
Dirk V
DV
ETH Zurich, D-CHAB, Switzerland. metals-in-medicine@phys.chem.ethz.ch
Chifotides
Helen T
HT
D000970:Antineoplastic Agents / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011789:Quantum Theory
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; C519986:dirhodium tetracarboxylate; D006147:Guanine