Clinicopathologic significance of an immunohistochemical expression of p27 in scirrhous carcinoma of the breast.
BACKGROUND
Scirrhous carcinoma has been known to have more aggressive biological behavior than other histologic subtypes of invasive ductal carcinoma of the breast. The significance of expression of p27kip1, which is thought to be a tumor suppressor gene, in breast carcinoma remains controversial. The aim of the current study was to clarify clinicopathologic significance of scirrhous carcinoma of the breast with special reference to p27 expression.


METHODS
Clinicopathologic features including immunohistochemical expression of p27 were compared between scirrhous carcinoma (n=42) and non-scirrhous invasive ductal carcinoma (papillotubular and solid-tubular carcinoma, n=63) of the breast.


RESULTS
The proportion of pathologic lymph node metastasis among scirrhous carcinomas was significantly higher than that among carcinomas of other histologic types (papillotubular or solid-tubular carcinomas, p=0.029). The proportion of strong expression of p27 among scirrhous carcinomas was significantly lower than that among tumors of other histologic types (p<0.0001).


CONCLUSIONS
Biological behavior of scirrhous carcinoma was found to be aggressive. The aggressiveness and poor cellular differentiation of scirrhous carcinoma of the breast might be related to low p27 expression.
Nozoe
Tadahiro
T
Second Department of Surgery, University of Environmental & Occupational Health, Iseigaoka, Kitakyushu, Japan. ntvb@med.uoeh-u.ac.jp
Oyama
Tsunehiro
T
Mori
Emiko
E
Uramoto
Hidetaka
H
Takenoyama
Mitsuhiro
M
Hanagiri
Takeshi
T
Sugio
Kenji
K
Yasumoto
Kosei
K
D002293:Adenocarcinoma, Scirrhous / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
D014408:Biomarkers, Tumor; D050760:Cyclin-Dependent Kinase Inhibitor p27