Nucleoprotein assemblies at the nanoscale: medical implications.
Bionanotechnology is exploiting the rich structural knowledge now available on DNA and DNA-protein interactions to construct nucleoprotein-based devices that have the potential not only to contribute to our understanding of the structure and function of the proteins and nucleic acids involved but also to new approaches to problems in medicine. Assemblies under development currently are poised to contribute to diagnosis and therapy. Here, I discuss recent work in this emerging field.
Smith
Steven S
SS
City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA. ssmith@coh.org
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods / Q000639:trends*; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000648:ultrastructure; D050997:Nanomedicine / Q000295:instrumentation / Q000379:methods / Q000639:trends*; D009698:Nucleoproteins / Q000737:chemistry* / Q000648:ultrastructure; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation / Q000379:methods / Q000639:trends*; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods / Q000639:trends*; D025941:Protein Interaction Mapping / Q000295:instrumentation / Q000379:methods / Q000639:trends*
D046912:Multiprotein Complexes; D009698:Nucleoproteins