title: Occupational lead exposure in battery manufacturing workers, silver jewelry workers, and spray painters in western Maharashtra (India): effect on liver and kidney function.
abstract: We studied liver and kidney function tests of occupational lead exposed Battery Manufacturing Workers (BMW) (n = 30), Silver Jewelry Workers (SJW) (n = 30), and Spray Painters (SP) (n = 35) and normal healthy subjects (n = 35), all 20 to 40 years of age, in Western Maharashtra (India). Venous blood and random urine samples were collected from all groups. The blood lead (Pb-B) and urinary lead (Pb-U) levels were significantly increased in all experimental groups, except urinary lead excretion in SJW as compared with the controls. Liver functions tests parameters (serum transaminase enzymes SGOT, AST, SGPT, ALT) activities were significantly increased only in SP; no alteration was noticed in BMW and SJW as compared with the control group. Serum total protein levels were significantly decreased in all three experimental groups as compared with control subjects. Serum albumin concentrations were significantly decreased in SJW, SP, and increased in BMW. The serum globulin levels, however, were significantly decreased, and the albumin/globulin (A/G) ratio was increased in BMW and SJW as compared with the control. The bilirubin level was significantly increased only in BMW. Blood urea was significantly increased only in BMW, and blood urea and serum uric acid were decreased in SJW. The serum creatinine level was not significantly altered in any experimental groups. Increased Pb-B values in all experimental groups indicate the greater rate of lead absorption and impairment of liver and kidney functions in all three types of occupational lead-exposed workers of Western Maharashtra (India).
authors: Department of Biochemistry, B.L.D.E.A's Sri B.M. Patil Medical College, Bijapur, Karnataka, Pin-586103, India.
authors: Arun J
authors: AJ
authors: Patil
authors: Vinod R
authors: VR
authors: Bhagwat
authors: Jyotsna A
authors: JA
authors: Patil
authors: Nilima N
authors: NN
authors: Dongre
authors: Jeevan G
authors: JG
authors: Ambekar
authors: Kusal K
authors: KK
authors: Das
mesh_terms: D000328:Adult; D001663:Bilirubin / Q000378:metabolism; D001798:Blood Proteins / Q000187:drug effects; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D006801:Humans; D007194:India; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007677:Kidney Function Tests; D007854:Lead / Q000097:blood / Q000633:toxicity* / Q000652:urine; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008669:Metallurgy; D016273:Occupational Exposure; D010150:Paint; D012709:Serum Albumin / Q000187:drug effects; D012712:Serum Globulins / Q000187:drug effects; D012834:Silver; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D001798:Blood Proteins; D012709:Serum Albumin; D012712:Serum Globulins; D014527:Uric Acid; D007854:Lead; D012834:Silver; D014508:Urea; D003404:Creatinine; D001663:Bilirubin