[Clinical analysis of dermatofibrosarcoma protuberans in head and neck].
OBJECTIVE
To evaluate the prognosis of dermatofibrosarcoma protuberans (DFSP) in head and neck after deferent treatment.


METHODS
The clinical data of 28 cases of DFSP in head and neck from 1982 to 2005 were analyzed retrospectively. Eleven cases were treated with wide excision, and 17 with limited excision. Twenty four cases had surgical resection alone (S), and 4 preoperative or postoperative radiotherapy (S + R) of 40-65 Gy. Eighteen cases received immediate reconstruction.


RESULTS
The overall recurrence rate was 21.4% (6/28), the recurrence rate of wide excision group was 0 (0/11), compared with 35.3% (6/17) in the limited excision group (P = 0.033); the recurrence rate of S + R group was 0 (0/4), compared with 25.0% (6/24) in S group, but there was no significant deference (P = 0.357). The overall 5-year survival rate was 88.9%. The 5-year recurrence free survival rate was 100% in wide excision group, compared with 59.6% in the limited excision group (chi2 = 3.933, P = 0.047).


CONCLUSIONS
Wide excision could significantly reduce the recurrence rate of DFSP in head and neck, when the adequate margin couldn't be achieved or the excision margin was positive, adjuvant radiotherapy might be helpful. The immediate reconstruction was necessary when the defect was large.
Ni
Song
S
Department of Head and Neck Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
Xu
Zhen-gang
ZG
Wang
Xiao-lei
XL
Liu
Shao-yan
SY
Lu
Ning
N
Xue
Li-yan
LY
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018223:Dermatofibrosarcoma / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis / Q000601:surgery*; D055815:Young Adult