Effect of oral supplementation with iron(III)-hydroxide polymaltose complex on the immunological profile of adolescents with varying iron status.
OBJECTIVE
To assess the effects of iron supplementation on immunological parameters of adolescents with varying iron status.


METHODS
Adolescents of both sexes with varying iron status were allocated to four treatment groups by using inclusion criteria. Three of the four groups received iron(III)-hydroxide polymaltose complex (IPC, Maltofer) containing 100 mg of iron 6 days a week for 8 months. The fourth group was given a placebo. Immunological parameters were assessed at baseline and after 4 and 8 months of supplementation.


RESULTS
Increases from baseline to 4 months and from 4 to 8 months of supplementation were observed for Bactericidal Capacity of Neutrophils (BCA), NitroBlue Tetrazolium Reduction Test (NBT), and phytohaemagglutinin (PHA) in all three supplemented groups. No increase was found in the control placebo group except for PHA. No side effects were noted in any participants.


CONCLUSIONS
IPC supplementation for eight months led to significant improvements of immunological parameters in iron deficient adolescents with and without anemia.
Devaki
Pallaki Baby
PB
Department of Home Science, S.V University, Tirupati, India. pbabydevaki@yahoo.co.in
Chandra
Ranjeet K
RK
Geisser
Peter
P
D000328:Adult; D000906:Antibodies / Q000032:analysis; D015703:Antigens, CD / Q000276:immunology; D015992:Body Mass Index; D019587:Dietary Supplements; D005260:Female; D005290:Ferric Compounds / Q000494:pharmacology*; D005293:Ferritins / Q000378:metabolism; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D007501:Iron / Q000097:blood*; D000090463:Iron Deficiencies; D018655:Lymphocyte Count; D008297:Male; D009752:Nutritional Status / Q000276:immunology*; D010835:Phytohemagglutinins; D014168:Transferrin / Q000378:metabolism
D000906:Antibodies; D015703:Antigens, CD; D005290:Ferric Compounds; D010835:Phytohemagglutinins; D014168:Transferrin; D005293:Ferritins; D007501:Iron; C013276:teferrol