title: Morphoeic basal cell carcinoma of the face.
abstract: The morphoeic (or sclerosing) basal cell carcinoma (mBCC) is the most aggressive subtype, as it spreads into the dermis beyond the clinically visible or palpable borders, making complete excision difficult. Our aim was to identify variables in the surgical management that might increase the rate of complete resection, so we made a retrospective study of 97 mBCCs. One-stage procedures (frozen section analysis) had a higher rate of complete resection (63 of 69, 91%) than two-stage procedures (permanent section analysis) (19 of 28, 68%, p<0.05). The false negative rate of frozen section analysis was 9%. Experienced surgeons had more complete excisions and a lower rate of operative re-excisions. The use of frozen section analysis is an effective way of judging invasion of margins by mBCC. The estimation of tumour margins and the treatment of mBCC requires substantial clinical experience.
authors: Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital Basel, CH-4031 Basel, Switzerland. erbap@uhbs.ch
authors: Paolo
authors: P
authors: Erba
authors: Jian
authors: J
authors: Farhadi
authors: Reto
authors: R
authors: Wettstein
authors: Andreas
authors: A
authors: Arnold
authors: Thomas
authors: T
authors: Harr
authors: Gerhard
authors: G
authors: Pierer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002983:Clinical Competence; D005153:Facial Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D005629:Frozen Sections; D006801:Humans; D008297:Male; D008875:Middle Aged; D018295:Neoplasms, Basal Cell / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*