title: Alpha-methylated polyamines as potential drugs and experimental tools in enzymology.
abstract: We describe synthesis of alpha-methylated analogues of the natural polyamines and their use as tools in unraveling polyamine functions. Experiments with alpha-methylated spermidine and spermine revealed that the polyamines are exchangeable in supporting cellular growth. Degradation of the analogues by polyamine oxidase disclosed hidden, aldehyde-guided stereospecificity of the enzyme.
authors: Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, P.O. Box 1627, FI-70211, Kuopio, Finland.
authors: Tuomo A
authors: TA
authors: Keinänen
authors: Aki
authors: A
authors: Järvinen
authors: Anne
authors: A
authors: Uimari
authors: Jouko
authors: J
authors: Vepsäläinen
authors: Alex R
authors: AR
authors: Khomutov
authors: Nikolay A
authors: NA
authors: Grigorenko
authors: Mervi T
authors: MT
authors: Hyvönen
authors: Marc
authors: M
authors: Cerrada-Gimenez
authors: Leena
authors: L
authors: Alhonen
authors: Juhani
authors: J
authors: Jänne
mesh_terms: D015195:Drug Design; D004798:Enzymes / Q000378:metabolism*; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism; D011073:Polyamines / Q000138:chemical synthesis* / Q000378:metabolism*; D000097667:Polyamine Oxidase
chemical_list: D004798:Enzymes; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011073:Polyamines; D000097667:Polyamine Oxidase