Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus.
Callophycoic acids A-H (1-8) and callophycols A and B (9 and 10) were isolated from extracts of the Fijian red alga Callophycus serratus, and identified by NMR, X-ray, and mass spectral analyses. These natural products represent four novel carbon skeletons, providing the first examples of diterpene-benzoic acids and diterpene-phenols in macroalgae. Compounds 1-10 exhibited antibacterial, antimalarial, and anticancer activity, although they are less bioactive than diterpene-benzoate macrolides previously isolated from this red alga.
Lane
Amy L
AL
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Stout
Elizabeth P
EP
Hay
Mark E
ME
Prusak
Anne C
AC
Hardcastle
Kenneth
K
Fairchild
Craig R
CR
Franzblau
Scott G
SG
Le Roch
Karine
K
Prudhomme
Jacques
J
Aalbersberg
William
W
Kubanek
Julia
J
D000818:Animals; D001565:Benzoates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*
D001565:Benzoates; D004224:Diterpenes; D010636:Phenols
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