Oligomers of resveratrol and ferulic acid prepared by peroxidase-catalyzed oxidation and their protective effects on cardiac injury.
Peroxidase extracted from Momordica charantia was used for the oligomerization of trans-resveratrol and ferulic acid on a preparative scale. One new heterocoupling oligomer, trans-3 E-3-[(4-hydroxy-3-methoxyphenyl)methylene]-4-(3,5-dihydroxyphenyl)-5-(4-hydroxyphenyl)tetrahydro-2-franone (6), and six resveratrol dimers, leachianol G (1), restrytisol B (2), parthenostilbenins A (3) and B (5), 7- O-acetylated leachianol G (4), and resveratrol trans-dehydrodimer (8), and one known ferulic acid dehydrodimer, (3alpha,3aalpha,6alpha,6aalpha)tetrahydro-3,6-bis(4-hydroxy-3-methoxyphenyl)-1 H,4 H-furo[3,4-c]furan-1,4-dione (7) were obtained. Bioactive experiments showed that compounds 6- 8 have strong free radical scavenging effects and also have protective effects on doxorubicin-induced cardiac cell injury when tested in vitro.
Yu
Bei-Bei
BB
School of Pharmaceutical Sciences, Shandong University, Jinan 250012, People's Republic of China.
Han
Xiu-Zhen
XZ
Lou
Hong-Xiang
HX
D000818:Animals; D002460:Cell Line; D003373:Coumaric Acids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D005638:Fruit / Q000201:enzymology; D006321:Heart / Q000187:drug effects; D006331:Heart Diseases / Q000517:prevention & control*; D029777:Momordica charantia / Q000201:enzymology; D009206:Myocardium / Q000166:cytology; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism*; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
D003373:Coumaric Acids; D013267:Stilbenes; C004999:ferulic acid; D009195:Peroxidase; D000077185:Resveratrol