Corticosteroids to prevent postextubation upper airway obstruction: the evidence mounts.
Intubation of the airway can lead to laryngotracheal injury, resulting in extubation failure from upper airway obstruction (UAO). A number of factors can help to identify patients who are at greatest risk for postextubation UAO. Three randomized controlled trials demonstrate that prophylactic corticosteroids decrease the risk for postextubation UAO and probably the need for re-intubation.
Epstein
Scott K
SK
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000402:Airway Obstruction / Q000209:etiology* / Q000517:prevention & control*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D003907:Dexamethasone
Intensive Care Med. 2003 Jan;29(1):69-74
12528025
Crit Care Med. 2006 May;34(5):1345-50
16540947
Lancet. 2007 Mar 31;369(9567):1083-9
17398307
J Am Coll Surg. 2000 Jun;190(6):682-7
10873003
Crit Care. 2007;11(4):R72
17605780
Crit Care. 2005 Feb;9(1):R24-31
15693963
J Crit Care. 2004 Mar;19(1):23-8
15101002
Respir Care. 2005 Dec;50(12):1632-8
16318644
Pediatr Crit Care Med. 2002 Jul;3(3):223-226
12780960
Chest. 1996 Oct;110(4):1035-40
8874265
Chest. 2001 Dec;120(6 Suppl):464S-8S
11742966
Intensive Care Med. 2002 May;28(5):535-46
12029399
Intensive Care Med. 2002 Sep;28(9):1267-72
12209275