title: Diguanylate cyclase activation: it takes two.
abstract: Characterization of an activated diguanylate cyclase reported in this issue of Structure by Wassmann et al. (2007) reveals how phosphorylation promotes dimerization necessary for synthesis of the second messenger c-di-GMP, establishes the catalytic mechanism, and identifies a widely conserved mode of product inhibition.
authors: Ann M
authors: AM
authors: Stock
mesh_terms: D002384:Catalysis; D019281:Dimerization; D004789:Enzyme Activation; D029968:Escherichia coli Proteins; D008954:Models, Biological; D019761:Phosphorus-Oxygen Lyases / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D015290:Second Messenger Systems
chemical_list: D029968:Escherichia coli Proteins; D019761:Phosphorus-Oxygen Lyases; C060720:diguanylate cyclase