title: [Two year investigation of glycosylation profiles in serum IgG from a patient with multiple myeloma].
abstract: Although abnormalities of glycosylation profile in serum IgG have been demonstrated in a variety of inflammatory autoimmune diseases such as rheumatoid arthritis, there are only a few reports describing long term monitoring of N-glycosylation profiles in such patients. Here we report the serial finding of N-glycosylation profiles of IgG-kappa M-protein in a patient with multiple myeloma monitored for two years. In this patient, serum formed a gel precipitation upon exposure to air. The HPLC mapping method demonstrated that IgG M-protein in the patient exhibited a significant decrease in the ratio of fucosyl to afucosyl N-glycans compared with that in a healthy control. With remission, the IgG M-protein showed an increase in this ratio, becoming closer to that in the healthy control. However, the gel-precipitation persisted. This finding suggested that this unique property of serum may not be related to the glycosylation profile of the M-protein.
authors: Department of Clinical Laboratory, Kobe City Medical Center General Hospital, Kobe 650-0046.
authors: Tatsuo
authors: T
authors: Oita
authors: Hirokazu
authors: H
authors: Yagi
authors: Akiko
authors: A
authors: Yamashiro
authors: Kenji
authors: K
authors: Sakizono
authors: Kenichi
authors: K
authors: Nagai
authors: Shinpei
authors: S
authors: Kasakura
authors: Koichi
authors: K
authors: Kato
authors: Noriko
authors: N
authors: Takahashi
mesh_terms: D006023:Glycoproteins / Q000097:blood; D006031:Glycosylation; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D009101:Multiple Myeloma / Q000097:blood*
chemical_list: D006023:Glycoproteins; D007074:Immunoglobulin G; C023587:protein M (glycoprotein)