Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance.
Adiponectin plays an important role in insulin sensitivity via adiponectin receptor 1 and 2 signalling. To date, six genetic association studies have examined the role of polymorphisms in the adiponectin receptor 1 and 2 genes (ADIPOR1 and ADIPOR2) in insulin resistance and type 2 diabetes. These studies are summarized in this review along with unpublished data from the authors. In addition, these polymorphism studies are used to illustrate some of the potential pitfalls and reasons for poor reproducibility of findings in genetic association studies.
Crimmins
N A
NA
Division of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. nancy.crimmins@cchmc.org
Martin
L J
LJ
D052242:Adiponectin / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D011110:Polymorphism, Genetic; D054419:Receptors, Adiponectin; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism
C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; D052242:Adiponectin; D054419:Receptors, Adiponectin; D011956:Receptors, Cell Surface