Crosstalk between apoptosis and antioxidants in melanoma vasculogenic mimicry.
The concept of "vasculogenic mimicry" (VM) was introduced to describe the unique ability of highly aggressive tumor cells to form capillary-like structure (CLS) and matrix-rich patterned network in three-dimensional cultures that mimic embryonic vasculogenic network. Here, we provide the experimental evidence that CLS structure formation requires apoptotic cell death through activation of caspase-dependent mechanism. Our results indicate that the formation of CLS is also related to the reactive oxygen species (ROS) levels.
Vartanian
Amalia
A
Department of Experimental Diagnosis and Biotherapy of Tumors, Russian Cancer Research Center, Moscow, Russia. amaliavartanian@hotmail.com
Baryshnikov
Anatoly Yu
AY
D000975:Antioxidants / Q000378:metabolism*; D017209:Apoptosis; D002196:Capillaries / Q000378:metabolism; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D045304:Cytochromes c / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005434:Flow Cytometry; D006801:Humans; D008545:Melanoma / Q000378:metabolism*; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D017382:Reactive Oxygen Species / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism*; D013997:Time Factors
D000975:Antioxidants; D017382:Reactive Oxygen Species; D045304:Cytochromes c; D020169:Caspases