Synthesis, characterization, and hydrolytic degradation behavior of a novel biodegradable pH-sensitive hydrogel based on polycaprolactone, methacrylic acid, and poly(ethylene glycol).
In this work, a new kind of biodegradable pH-sensitive hydrogel was successfully synthesized by UV-initiated free radical polymerization. The obtained hydrogel was characterized by (1)H NMR and FTIR. Swelling behavior in different aqueous media and pH responsivity of the hydrogels were studied in detail as well. With increase in pH from 1.2 to 7.2, swelling ratio of the hydrogel increased. The morphology was observed by scanning electron microscopy, and the hydrolytic degradation behavior was also investigated in this work.
Chao
Guo Tao
GT
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
Qian
Zhi Yong
ZY
Huang
Mei Juan
MJ
Kan
Bing
B
Gu
Ying Chun
YC
Gong
Chang Yang
CY
Yang
Jin Liang
JL
Wang
Ke
K
Dai
Mei
M
Li
Xing Yi
XY
Gou
Ma Ling
ML
Tu
Ming Jing
MJ
Wei
Yu Quan
YQ
D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010777:Photochemistry; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
D020100:Hydrogels; D008689:Methacrylates; D011091:Polyesters; C008384:methacrylic acid; C016240:polycaprolactone; D011092:Polyethylene Glycols