title: Acute promyelocytic leukemia: an unusual cause showing prolonged disseminated intravascular coagulation after placental abruption.
abstract: BACKGROUND
  Disseminated intravascular coagulation (DIC) caused by placental abruption usually improves rapidly after prompt delivery and adequate anti-DIC treatment.
  
  
  METHODS
  A 30-year-old nulliparous woman suffered from placental abruption at the 25th week of pregnancy, and emergent cesarean section was done immediately. She exhibited DIC, which continued even after termination of the pregnancy and anti-DIC treatment. She also showed neutropenia. We closely observed her, and at the 58th day postpartum, blast cells appeared in the peripheral blood and she was diagnosed with acute promyelocytic leukemia (APL). Induction chemotherapy was done successfully. The close observation after delivery enabled us to make the prompt diagnosis/treatment, leading to the complete remission.
  
  
  CONCLUSIONS
  APL should be added to the list of differential diagnosis when DIC persists even after prompt delivery and appropriate anti-DIC treatment after placental abruption.
authors: Department of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan.
authors: Yukako
authors: Y
authors: Morimatsu
authors: Shigeki
authors: S
authors: Matsubara
authors: Noriko
authors: N
authors: Hirose
authors: Akihide
authors: A
authors: Ohkuchi
authors: Akio
authors: A
authors: Izumi
authors: Katsutoshi
authors: K
authors: Ozaki
authors: Keiya
authors: K
authors: Ozawa
authors: Mitsuaki
authors: M
authors: Suzuki
mesh_terms: D000037:Abruptio Placentae / Q000209:etiology* / Q000601:surgery; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002585:Cesarean Section; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis* / Q000188:drug therapy; D009503:Neutropenia / Q000209:etiology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents