Remodeling the model organism: matrix metalloproteinase functions in invertebrates.
The matrix metalloproteinase (MMP) family of extracellular proteases is conserved throughout the animal kingdom. Studies of invertebrate MMPs have demonstrated they are involved in tissue remodeling. In Drosophila, MMPs are required for histolysis, tracheal growth, tissue invasion, axon guidance, and dendritic remodeling. Recent work demonstrates that MMPs also participate in Drosophila tumor invasion. In Caenorhabditis elegans an MMP is involved in anchor cell invasion; a Hydra MMP is important for regeneration and maintaining cell identity; and a sea urchin MMP degrades matrix to allow hatching. In worms and in flies, MMPs are regulated by the JNK pathway.
Page-McCaw
Andrea
A
Center for Biotechnology and Interdisciplinary Studies and Department of Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. pagema@rpi.edu
D000818:Animals; D001370:Axonal Transport / Q000502:physiology; D017173:Caenorhabditis elegans / Q000201:enzymology / Q000235:genetics; D003713:Dendritic Cells / Q000502:physiology; D004331:Drosophila melanogaster / Q000201:enzymology / Q000235:genetics; D006829:Hydra / Q000201:enzymology / Q000502:physiology; D007448:Invertebrates / Q000201:enzymology* / Q000502:physiology*; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D023421:Models, Animal; D008954:Models, Biological; D009361:Neoplasm Invasiveness / Q000235:genetics; D011485:Protein Binding; D012038:Regeneration / Q000502:physiology*; D012617:Sea Urchins / Q000201:enzymology / Q000502:physiology; D019714:Tissue Inhibitor of Metalloproteinases / Q000502:physiology
D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases
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