Lack of association of XRCC1 codon 399Gln polymorphism with chronic myelogenous leukemia.
BACKGROUND
Recent studies suggest that single nucleotide polymorphisms in different genes may modulate the susceptibility to chronic myelogenous leukaemia (CML). Here, the association of the common XRCC1 gene polymorphism Arg399Gln at codon 399 in CML was investigated.


METHODS
Genotyping was performed by melting curve analysis in samples from peripheral blood or bone marrow.


RESULTS
The frequency of the variant allele 399Gln was similar between the control group and the patients (35.2% and 34.9%, respectively; p = 0.21). Similarly, the heterozygote and homozygote variant genotypes displayed a homogenous distribution in both groups (p > 0.05 for all comparisons). Moreover, distribution of the variant allele and subgenotypes did not significantly differ between the patient subgroups with a diagnosis age below or above 50 years.


CONCLUSIONS
To our knowledge, this is the first study to investigate the role of any XRCC1 polymorphism in CML and our findings do not support a role of codon 399Gln polymorphism in CML.
Deligezer
Ugur
U
Department of Basic Oncology, Oncology Institute, Istanbul University, Istanbul, Turkey.
Akisik
Ebru E
EE
Dalay
Nejat
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D003062:Codon; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000076105:X-ray Repair Cross Complementing Protein 1
D003062:Codon; D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human