title: Estrogenic constituents of the heartwood of Dalbergia parviflora.
abstract: From the heartwood of Dalbergia parviflora, five compounds, dalparvin A (1), B (2), C (3), dalparvinol C (4), and neokhriol A (5), along with 11 known compounds, kenusanone G (6), cajanin (7), sophorol (8), alpinetin (9), hesperetin (10), 3'-O-methylorobol, odoratin, (2R)(3R)-2,3-trans 7-hydroxy-5-methoxydihydroflavonol, (6aR, 11aR)-3,8-dihydroxy-9-methoxypterocarpan, (6aR, 11aR)- vesticarpan, and methyl-3,4-dihydroxy-2-methoxybenzoate were isolated and characterized. Isolates were evaluated for their cell proliferation stimulatory activity against MCF-7, T-47D, and BT20 human breast cancer cell lines. Along with 7-10, two compounds 2 and 3 stimulated not only MCF-7, but also T-47D human breast cancer cell proliferation. Compound 6 had activity only against MCF-7 cells, and the activity of 7 was more than equivalent to that of daidzein. On the other hand, none of the isolates had any significant effects on BT20 cell proliferation, and these results indicated that the stimulative activity of these compounds was not general to any cell proliferations. Furthermore, these compounds were tested in the estrogen-responsive transient luciferase reporter assay.
authors: School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. umehara@ys7.u-shizuoka-ken.ac.jp
authors: Kaoru
authors: K
authors: Umehara
authors: Kiyomitsu
authors: K
authors: Nemoto
authors: Kyoko
authors: K
authors: Kimijima
authors: Ayako
authors: A
authors: Matsushita
authors: Eri
authors: E
authors: Terada
authors: Orawan
authors: O
authors: Monthakantirat
authors: Wanchai
authors: W
authors: De-Eknamkul
authors: Toshio
authors: T
authors: Miyase
authors: Tsutomu
authors: T
authors: Warashina
authors: Masakuni
authors: M
authors: Degawa
authors: Hiroshi
authors: H
authors: Noguchi
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D035782:Dalbergia / Q000033:anatomy & histology* / Q000737:chemistry*; D004967:Estrogens / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D017930:Genes, Reporter; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014934:Wood / Q000737:chemistry*
chemical_list: D004967:Estrogens