The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress.
Recently, it has been elucidated that cognitive dysfunction following cranial radiotherapy might be linked to the oxidative stress-induced impairment of hippocampal neurogenesis that is mediated by proliferating neural stem or progenitor cells. The novel free-radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) has been clinically used to reduce neuronal damage following ischemic stroke. Here, we demonstrate via in vitro studies that edaravone protects human neural stem cells (NSCs) from cell death and restores their differentiation ability after irradiation; however, the protective effect of edaravone is not observed in human brain tumor cells. Our study may shed some light on the beneficial effects of free-radical scavengers in impaired neurogenesis following cranial radiation therapy.
Ishii
Jun
J
Department of Biosciences, Teikyo University of Science and Technology, Uenohara, Yamanashi 409-0193, Japan.
Natsume
Atsushi
A
Wakabayashi
Toshihiko
T
Takeuchi
Hiroki
H
Hasegawa
Hiroyuki
H
Kim
Seung U
SU
Yoshida
Jun
J
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001932:Brain Neoplasms / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005910:Glioma / Q000473:pathology; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000378:metabolism / Q000473:pathology* / Q000528:radiation effects; D018384:Oxidative Stress; D011832:Radiation Injuries / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology* / Q000528:radiation effects
D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine