title: Geometrical regularization of displacement fields for histological image registration.
abstract: This article tackles the registration of 2-D biomedical images (histological sections, autoradiographs, cryosections, etc.). Our goal is to adequately match anatomical features of interest without inducing biologically improbable tissue distortions. We observe that the large variety of registration applications--3-D volume reconstruction, multimodal molecular mapping, etc.--induce a no less diverse set of requirements in terms of accuracy and robustness. In turn, these directly translate into regularization constraints on the deformation model, which should ideally be specifiable by the user. We propose an adaptive regularization approach where the rigidity constraints are informed by the registration application at hand and whose support is controlled by the geometry of the images to be registered. For each site of a sparse lattice over which a displacement field has been computed, our algorithm estimates, in a robust fashion, a rigid or affine transformation within a circular neighbourhood cut to fit the local geometry around the site. We investigate the behaviour of this technique and discuss its sensitivity to the rigidity parameter.
authors: Laboratory of Image and Data Analysis, Brain and Body Centre, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom. alain.pitiot@nottingham.ac.uk
authors: Alain
authors: A
authors: Pitiot
authors: Alexandre
authors: A
authors: Guimond
mesh_terms: D000465:Algorithms; D000818:Animals; D001931:Brain Mapping / Q000379:methods; D006652:Histological Techniques; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional; D051379:Mice