Tandem bis-aldol reaction of ketones: a facile one-pot synthesis of 1,3-dioxanes in aqueous medium.
A novel tandem bis-aldol reaction of ketone with paraformaldehyde catalyzed by polystyrenesulfonic acid in aqueous medium delivers 1,3-dioxanes in high yield. This one-pot, operationally simple microwave-assisted synthetic protocol proceeds efficiently in water in the absence of organic solvent, with excellent yield.
Polshettiwar
Vivek
V
Sustainable Technology Division, National Risk Management Research Laboratory, U. S. Environmental Protection Agency, Cincinnati, OH 45268, USA.
Varma
Rajender S
RS
D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D004146:Dioxanes / Q000138:chemical synthesis*; D044950:Flavanones / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D012996:Solutions; D014867:Water / Q000737:chemistry
D000438:Alcohols; D000447:Aldehydes; D004146:Dioxanes; D044950:Flavanones; D007659:Ketones; D012996:Solutions; D014867:Water; C028610:flavanone