title: Continuous hyperthermic peritoneal perfusion for desmoplastic small round cell tumor.
abstract: Desmoplastic small round cell tumor (DSRCT) is a rare disease of children, adolescents, and young adults that begins and spreads on the peritoneal surfaces. Desmoplastic small round cell tumor usually presents with diffuse abdominal metastatic disease similar in gross appearance to carcinomatosis. To date, very aggressive treatment programs have yielded dismal outcomes. Here we present 2 cases of DSRCT that were treated with aggressive surgical excision followed by intraoperative continuous hyperthermic peritoneal perfusion using cisplatin. These are the first pediatric case reports of DSRCT being treated with continuous hyperthermic peritoneal perfusion, a procedure usually used in treatment of adult carcinomatosis.
authors: Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center and MDACC-Children's Cancer Hospital, USA. andrea.hayes-jordan@uth.tmc.edu
authors: Andrea
authors: A
authors: Hayes-Jordan
authors: Pete
authors: P
authors: Anderson
authors: Steven
authors: S
authors: Curley
authors: Cynthia
authors: C
authors: Herzog
authors: Kevin P
authors: KP
authors: Lally
authors: Holly L
authors: HL
authors: Green
authors: Kelly
authors: K
authors: Hunt
authors: Paul
authors: P
authors: Mansfield
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D006979:Hyperthermia, Induced; D007263:Infusions, Parenteral; D000077146:Irinotecan; D008297:Male; D000077204:Temozolomide
chemical_list: D000077146:Irinotecan; D003606:Dacarbazine; D002945:Cisplatin; D002166:Camptothecin; D000077204:Temozolomide