Hippocampal differentiation without recognition: an fMRI analysis of the contextual cueing task.
A central role of the hippocampus is to consolidate conscious forms of learning and memory, while performance on implicit tasks appears to depend upon other structures. Recently, considerable debate has emerged about whether hippocampal-dependent tasks necessarily entail task awareness. In the contextual cueing task, repetition facilitation is implicit, but impaired in patients with amnesia. Whether the hippocampus alone or other MTL structures are required is unclear. Event-related functional magnetic resonance imaging revealed hippocampal activity that differentiates novel from repeated arrays. This pattern of results was observed without recognition of the repeating arrays. This finding provides support for the claim that the hippocampus is involved in processes outside the domain of conscious learning and memory.
Greene
Anthony J
AJ
Department of Psychology, University of Wisconsin, Milwaukee, Wisconsin 53211, USA. ag@uwm.edu
Gross
William L
WL
Elsinger
Catherine L
CL
Rao
Stephen M
SM
D000293:Adolescent; D000328:Adult; D003243:Consciousness / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D010364:Pattern Recognition, Visual / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D021641:Recognition, Psychology; D013702:Temporal Lobe / Q000502:physiology; D014473:Unconscious, Psychology
Behav Neurosci. 2000 Jun;114(3):459-67
10883797
Annu Rev Neurosci. 2007;30:123-52
17417939
Psychol Sci. 2000 Nov;11(6):454-61
11202489
Hippocampus. 2001;11(6):776-82
11811672
Epilepsia. 2001;42 Suppl 6:19-23
11902315
Behav Neurosci. 2002 Aug;116(4):530-8
12148921
J Neurophysiol. 2002 Aug;88(2):982-90
12163547
Science. 2003 Jan 24;299(5606):577-80
12543980
Hippocampus. 2003;13(1):164-74
12625466
Hippocampus. 2003;13(2):250-9
12699332
J Cogn Neurosci. 2004 May;16(4):654-64
15165354
Annu Rev Neurosci. 2004;27:279-306
15217334
Clin Neurosurg. 1972;19:421-46
4637561
Ann N Y Acad Sci. 1985;444:54-71
3860122
Brain. 1995 Oct;118 ( Pt 5):1129-48
7496775
Nature. 1996 Apr 25;380(6576):715-7
8614466
J Exp Psychol Learn Mem Cogn. 1996 Jan;22(1):169-81
8648284
Comput Biomed Res. 1996 Jun;29(3):162-73
8812068
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13515-22
8942965
Science. 1997 Apr 11;276(5310):264-6
9092477
Memory. 1997 Jan-Mar;5(1-2):131-78
9156097
J Neurophysiol. 1997 Aug;78(2):1030-44
9307133
Science. 1998 Apr 3;280(5360):77-81
9525860
Cogn Psychol. 1998 Jun;36(1):28-71
9679076
Hippocampus. 1999;9(1):25-34
10088897
Behav Neurosci. 1999 Feb;113(1):3-9
10197901
Hippocampus. 2005;15(1):79-85
15390163
J Neurosci. 2005 Mar 30;25(13):3280-6
15800182
Neural Netw. 2005 Apr;18(3):225-30
15896570
Epilepsia. 2005 Jul;46(7):1061-70
16026558
Eur J Neurosci. 2005 Sep;22(6):1368-88
16190892
J Neurosci. 2005 Nov 2;25(44):10138-46
16267221
Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):756-61
16407110
Neuropsychologia. 2006;44(7):1185-94
16300806
J Cogn Neurosci. 2006 Jul;18(7):1156-73
16839289
Curr Biol. 2006 Aug 22;16(16):R643-5
16920614
Hippocampus. 2006;16(9):795-808
16881079
J Neurosci. 2006 Nov 1;26(44):11304-12
17079658
Hippocampus. 2007;17(6):429-33
17455198
Nat Neurosci. 1999 Sep;2(9):844-7
10461225