title: Potential biochemical therapy of glioma cancer.
abstract: Glioma is a highly invasive, rapidly spreading form of brain cancer that is resistant to surgical and medical treatment. The recent progresses made in intracellular and ion channels of glioma cells provide a potential new approach for biochemical therapy of brain tumor. In this paper, we reviewed clinical data on chemotherapy by temozolomide and results from new studies on voltage-gated potassium channels, large-conductance Ca(2+)-activated K(+) channels, volume-activated chloride channels, glioma-specific chloride channel and their modulators. These new findings may represent future directions for brain tumor studies and treatment.
authors: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, PR China.
authors: Li-Tian
authors: LT
authors: Yin
authors: Yue-Jun
authors: YJ
authors: Fu
authors: Qiao-Ling
authors: QL
authors: Xu
authors: Jun
authors: J
authors: Yang
authors: Zeng-Li
authors: ZL
authors: Liu
authors: Ai-Hua
authors: AH
authors: Liang
authors: Xiao-Jun
authors: XJ
authors: Fan
authors: Cheng-Gang
authors: CG
authors: Xu
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D005910:Glioma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000627:therapeutic use; D008954:Models, Biological; D015394:Molecular Structure; D026902:Potassium Channel Blockers / Q000627:therapeutic use; D024681:Potassium Channels, Calcium-Activated / Q000037:antagonists & inhibitors / Q000378:metabolism; D000077204:Temozolomide
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007211:Indoles; D026902:Potassium Channel Blockers; D024681:Potassium Channels, Calcium-Activated; C048220:paxilline; D003606:Dacarbazine; D000077204:Temozolomide