[Chorea. Causes, diagnosis, and therapy].
The differential diagnosis of chorea includes a growing number of rare diseases. This article gives hints on clinical differences and possible laboratory investigations which may help to identify the underlying disease. The majority of hereditary chorea cases are caused by Huntington's disease. Different courses of disease can be distinguished depending on age at disease onset. The diagnosis can be confirmed genetically. Predictive testing is also possible but should be applied with caution only following internationally accepted guidelines. Our knowledge about treatment of chorea is limited, and studies have focused on the use of neuroleptics only. Their value is often outweighed by serious side effects. All efforts to find disease-modifying therapies for Huntington's disease had negative outcomes so far. To face these therapeutic limitations, the European Huntington's Disease Network was formed as a platform supporting the development and undertaking of clinical studies in Huntington's disease to improve care for these patients.
Kosinski
C M
CM
Neurologische Klinik, Universitätsklinikum, Pauwelsstrasse 30, 52074, Aachen, Germany. CKosinski@ukaachen.de
Landwehrmeyer
B
B
D000047:Academies and Institutes; D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002819:Chorea / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D005820:Genetic Testing; D005858:Germany; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D051379:Mice; D018696:Neuroprotective Agents / Q000009:adverse effects / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D051381:Rats
D014150:Antipsychotic Agents; D018696:Neuroprotective Agents
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