Serum ghrelin levels but not GH, IGF-1 and IGFBP-3 levels are altered in patients with fibromyalgia syndrome.
BACKGROUND
Both hypothalamo-pituitary-insulin-like growth factor-1 (IGF-1) axis and ghrelin levels may be altered in fibromyalgia syndrome (FMS) due to increased somatostatin tone. The aim of this study is to compare hypothalamo-pituitary-IGF-1 axis, ghrelin concentrations and their relations in premenopausal women with FMS and premenopausal healthy controls.


METHODS
Seventy-five women (47 FMS and 28 healthy women) were enrolled in the study. Fasting plasma glucose, serum growth hormone (GH), insulin, C-peptide, IGF-1, insulin-like growth factor binding protein-3 (IGFBP-3) and ghrelin levels were measured. Depressive symptoms were assessed using beck depression inventory. Pain intensity and sleep disturbance were recorded on a visual analog scale. The activity of daily living was assessed by fibromyalgia impact questionnaire.


RESULTS
There were no significant differences in GH, IGF-1, IGFBP-3, glucose, insulin, and C-peptide levels between patients and controls (p>0.05), whereas ghrelin levels were significantly lower in patients than controls (p<0.05). Ghrelin levels were not correlated with GH, IGF-1, IGFBP-3, glucose, insulin, and C-peptide levels while they were positively correlated with tender point score and sleep disturbance score and negatively correlated with pain intensity score.


CONCLUSIONS
Our results suggest that low levels of ghrelin in FMS are not related to the changes in hypothalamo-pituitary-IGF-1 axis but may be related to some symptoms of FMS. Our results need to be clarified by further studies.
Tander
Berna
B
Department of Physical Medicine and Rehabilitation, Ondokuz Mayis University School of Medicine, 55139 Kurupelit, Samsun, Turkey. tander@omu.edu.tr
Atmaca
Aysegul
A
Aliyazicioglu
Yuksel
Y
Canturk
Ferhan
F
D000328:Adult; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D003863:Depression / Q000453:epidemiology; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000503:physiopathology / Q000523:psychology; D054439:Ghrelin; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007407:Interviews as Topic; D008875:Middle Aged; D010147:Pain Measurement; D036361:Peptide Hormones / Q000097:blood*; D017697:Premenopause; D012016:Reference Values; D012893:Sleep Wake Disorders / Q000453:epidemiology
D002096:C-Peptide; D054439:Ghrelin; D018972:Insulin-Like Growth Factor Binding Protein 3; D036361:Peptide Hormones; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I