Comparison of ultrasound score, CA125, menopausal status, and risk of malignancy index in differentiating between benign and borderline or malignant ovarian tumors.
OBJECTIVE
To evaluate the diagnostic performances of ultrasound score (US), CA 125, menopausal status, risk of malignancy index (RMI)-- in differentiating between benign and borderline or malignant ovarian tumors.


METHODS
Women with ovarian masses who were scheduled to have elective surgery at the Department of Obstetrics and Gynecology, BMA Medical College and Vajira Hospital between May 1999 and December 2001 were included in the study. Ultrasonographic study and CA 125 were examined preoperatively. The RMI was obtained from the ultrasound score, CA 125, and menopausal status. The diagnostic values of each parameter and the RMI were determined.


RESULTS
From 175 women, 35 women (20%) had malignant ovarian tumors. RMI yielded better diagnostic performance to differentiate between benign and borderline or malignant ovarian tumors than US score, CA 125, and menopausal status in respective order The optimal RMI to predict malignancy was 0.135 with the sensitivity of 88.6% (95% CI; 81.1%-96.1%), specificity of 90.7% (95% CI; 83.9%-97.6%), positive and negative predictive value of 70.5% (95% CI; 59.7%-81.2%) and 97.0% (95% CI; 92.9%-100.0%) respectively.


CONCLUSIONS
RMI yielded better diagnostic performance than the individual parameter of ultrasound score, CA 125, or menopausal status in differentiation of benign from borderline or malignant ovarian tumors.
Leelahakorn
Surawute
S
Department of Obstetrics and Gynecology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Bangkok, Thailand.
Tangjitgamol
Siriwan
S
Manusirivithaya
Sumonmal
S
Thongsuksai
Paramee
P
Jaroenchainon
Paiboon
P
Jivangkul
Chairak
C
D000328:Adult; D018394:CA-125 Antigen / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016015:Logistic Models; D010051:Ovarian Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging*; D017698:Postmenopause; D011237:Predictive Value of Tests; D017697:Premenopause; D012372:ROC Curve; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014463:Ultrasonography
D018394:CA-125 Antigen