title: Methylation status in females with rett syndrome.
abstract: The authors studied methionine and creatine metabolism in females with Rett syndrome. Plasma metabolites (including methionine, homocysteine, guanidinoacetate) and urine creatine/creatinine ratios in 29 females with Rett syndrome were within the age-appropriate range. Although the authors have not been able to identify any abnormalities, it can be speculated that patients with Rett syndrome may benefit from dietary intervention to increase the supply of labile methyl groups to affected tissues.
authors: Vienna University Hospital, Department of Pediatrics, Vienna, Austria.
authors: Michael
authors: M
authors: Freilinger
authors: David
authors: D
authors: Kalisch
authors: Adolf
authors: A
authors: Muehl
authors: Oskar
authors: O
authors: Haas
authors: Anne
authors: A
authors: Moritz
authors: Olaf
authors: O
authors: Bodamer
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003401:Creatine / Q000378:metabolism*; D005260:Female; D005492:Folic Acid / Q000097:blood; D006801:Humans; D008715:Methionine / Q000378:metabolism*; D051783:Methyl-CpG-Binding Protein 2 / Q000235:genetics; D008745:Methylation; D015518:Rett Syndrome / Q000178:diet therapy / Q000235:genetics / Q000378:metabolism*
chemical_list: C497392:MECP2 protein, human; D051783:Methyl-CpG-Binding Protein 2; D005492:Folic Acid; D008715:Methionine; D003401:Creatine