Linking SIRT2 to Parkinson's disease.
A recent study has identified selective inhibitors of the human silent information regulator 2 NAD (+)-dependent protein deacetylase, SIRT2, and has shown that these compounds protect against alpha-synuclein-mediated toxicity in cellular models of Parkinson's disease. The inhibitors were found to ameliorate dopaminergic cell death in vitro and in a Drosophila model of Parkinson's disease. Although the molecular mechanism of action is unclear, the compounds may function by promoting the formation of enlarged inclusion bodies, which are suggested to provide a cell-survival advantage.
Garske
Adam L
AL
Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Smith
Brian C
BC
Denu
John M
JM
D000818:Animals; D016923:Cell Death; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D004330:Drosophila / Q000201:enzymology; D006801:Humans; D010300:Parkinson Disease / Q000201:enzymology* / Q000473:pathology; D056565:Sirtuin 2; D037761:Sirtuins / Q000037:antagonists & inhibitors / Q000378:metabolism*
C474199:SIRT2 protein, human; D056565:Sirtuin 2; D037761:Sirtuins; D004298:Dopamine