Clinical comparison of two topical prednisolone acetate 1% formulations in reducing inflammation after cataract surgery.
OBJECTIVE
To compare the efficacy of two formulations of prednisolone acetate 1% in reducing postoperative inflammation in patients having primary phacoemulsification surgery with IOL implantation.


METHODS
This multicenter study was conducted in randomized, double-masked fashion with a parallel active control group. Patients undergoing phacoemulsification surgery with IOL implantation were assigned to one of two treatment groups receiving study drug in addition to standard therapy. Study drug was administered four times daily beginning one day before surgery, postoperatively for 14 days, then twice daily until the bottle was empty. Clinical efficacy was compared for differences in corneal surface keratitis, anterior chamber cells and flare, and postoperative pain. Results were compared on day 1, 2 weeks, and 4 weeks postoperatively.


RESULTS
No statistical differences in clinical efficacy or safety were seen between the two formulations tested at any time point evaluated.


CONCLUSIONS
In this study of routine cataract patients, both prednisolone acetate 1% formulations are comparably effective and safe when administered for the reduction of inflammation after phacoemulsification surgery with IOL implantation.
Raizman
Michael B
MB
Ophthalmic Consultants of Boston, Boston, MA 02114, USA. mbraizman@eyeboston.com
Donnenfeld
Eric D
ED
Weinstein
Arthur J
AJ
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002387:Cataract Extraction / Q000009:adverse effects*; D002626:Chemistry, Pharmaceutical; D004311:Double-Blind Method; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control*; D019654:Lens Implantation, Intraocular; D010149:Postoperative Pain / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; C009935:prednisolone acetate; D011239:Prednisolone