[Research advance on role of tumor microenvironment in mediating acquired drug resistance].
The emergence of clinical drug resistance continues to be an obstacle for the successful treatment of cancer. In the past twenty years, our primary understanding of the mechanisms associated with drug resistance has been ascertained through investigating unicellular drug-resistant models. These models are critical in elucidating drug-resistant mechanism and have aided in the identification of drug targets in some cases. However, these models do not address resistance mechanisms that contribute to acquired drug resistance. Therefore, to improve the efficacy of cancer chemotherapy, seeking and identifying the mechanisms of acquired drug resistance has become a hotspot in current researches. Many researches have suggested that tumor microenvironment plays an important role in mediating acquired drug resistance and confers resistance to physiologic mediators of cell death. The specific niches within it may provide a sanctuary for subpopulations of tumor cells that affords a survival advantage following initial drug exposure and may promote acquired drug resistance. Our review focused on tumor microenvironment and its role in mediating acquired drug resistance.
Ma
Xiao-Li
XL
Cancer Biology Medical Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, 430030, PR China.
Xing
Hui
H
Ma
Ding
D
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D002448:Cell Adhesion / Q000502:physiology; D049109:Cell Proliferation; D004249:DNA Damage / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction
D000970:Antineoplastic Agents; D016023:Integrins