One or two day mifepristone-misoprostol interval for second trimester abortion.
METHODS
A retrospective 2-year cohort study of 127 women, with gestation between 13 and 24 weeks and a live fetus, seeking induced abortion. The aim was to compare the effect of a 1-day and a 2-day interval between oral mifepristone (200 mg) and vaginal misoprostol (400 microg) every 3 h.


RESULTS
The time to fetal expulsion was longer (9.8 versus 7.5 h; p<0.01) in the 1-day than in the 2-day group, but the median number of applications were identical and abortion occurred in 98% within 24 h in both groups The time to abortion was longer in women with a gestation of 17-22 weeks compared to women with lower gestation (10.2 versus 6.8 h; p<0.001), and longer in nulliparae than in parous women (10.0 versus 6.7 h; p<0.001).


CONCLUSIONS
The combined regimen of mifepristone and misoprostol is effective in the second trimester, and the interval between the drugs can be reduced allowing individualised patient care.
Nilas
Lisbeth
L
Department of Obstetrics and Gynecology, Hvidovre Hospital, Denmark. lisbeth.nilas@hh.hosp.dk
Glavind-Kristensen
Marianne
M
Vejborg
Thomas
T
Knudsen
Ulla Breth
UB
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000494:pharmacology*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D000028:Abortion, Induced / Q000379:methods*; D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D020073:Gravidity; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage / Q000494:pharmacology*; D016595:Misoprostol / Q000008:administration & dosage / Q000494:pharmacology*; D010298:Parity; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D016595:Misoprostol; D015735:Mifepristone