No association between the DRD3 Ser9Gly polymorphism and schizophrenia.
OBJECTIVE
To investigate the association between a Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) and schizophrenia.


METHODS
408 schizophrenic patients and 172 control subjects were compared with regard to their DRD3 Ser9Gly genotypic and allelic frequencies. In addition, we carried out a family-based association study including 183 pedigrees (472 subjects) using the transmission disequilibrium test (TDT).


RESULTS
No significant differences of genotype or homozygosity distribution were identified between patients and controls. When patients were stratified according to gender, response to treatment, age at onset, no significant differences were observed. Neither allele A (Ser), or G (Gly) were preferentially transmitted from parents to affected offspring.


CONCLUSIONS
The hypothesis that the DRD3 Ser9Gly polymorphism plays a predisposing role in schizophrenia is not supported by this study.
Fathalli
Ferid
F
Douglas Hospital Research Centre, Montréal University, Québec, Canada. ferid.fathalli@douglas.mcgill.ca
Rouleau
Guy A
GA
Xiong
Lan
L
Tabbane
Karim
K
Benkelfat
Chawki
C
Deguzman
Rosherrie
R
Zoltan
Danics
D
Lal
Samarthji
S
D'cruz
Sarogini
S
Joober
Ridha
R
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005190:Family; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D005998:Glycine / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012694:Serine / Q000235:genetics; D044465:White People / Q000235:genetics
D014150:Antipsychotic Agents; C493593:DRD3 protein, human; D005819:Genetic Markers; D050637:Receptors, Dopamine D3; D012694:Serine; D005998:Glycine