title: Chromanones with leishmanicidal activity from Calea uniflora.
abstract: The dichloromethane extract of Calea uniflora afforded a mixture of two novel chromanones, uniflorol-A (1) and uniflorol-B (2), and one known chromanone, 2,2-dimethyl-6-(1-hydroxyethyl)-chroman-4-one (3). The structures of these compounds were determined by spectroscopic methods. Biological activity of the compounds against Leishmania major promastigotes was evaluated. Mixture of the novel chromanones 1 and 2 showed significant growth inhibition of the parasite in the micrograms per milliliter range.
authors: Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Via do Café s/n, 14040-903, Ribeirão Preto, SP, Brazil.
authors: Andréa Mendes
authors: AM
authors: do Nascimento
authors: Fernanda Cristina
authors: FC
authors: Costa
authors: Otavio Henrique
authors: OH
authors: Thiemann
authors: Dionéia Camilo Rodrigues
authors: DC
authors: de Oliveira
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002867:Chromones; D018320:Leishmania major / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D000981:Antiprotozoal Agents; D002867:Chromones; D010936:Plant Extracts; C469373:chaetomanone