title: Effects of Ginkgo biloba extract EGb 761 on neuropsychiatric symptoms of dementia: findings from a randomised controlled trial.
abstract: In a randomised, double-blind, 22-week trial 400 patients with dementia associated with neuropsychiatric features were treated with Ginkgo biloba extract EGb 761 (240 mg/day) or placebo. Patients with probable Alzheimer's disease, possible Alzheimer's disease with cerebrovascular disease or vascular dementia were eligible if they scored 9 to 23 on the SKT cognitive test battery and at least 5 on the Neuropsychiatric Inventory (NPI). EGb 761 was significantly superior to placebo with respect to the primary (SKT test battery) and all secondary outcome variables. The mean composite score (frequency x severity) and the mean caregiver distress score of the NPI dropped from 21.3 to 14.7 and 13.5 to 8.7, respectively, in the EGb 761-treated patients, but increased from 21.6 to 24.1 and 13.4 to 13.9, respectively, under placebo (p < 0.001). The largest drug-placebo differences in favour of EGb 761 were found for apathy/indifference, anxiety, irritability/lability, depression/dysphoria and sleep/nighttime behaviour.
authors: Poltava Regional Psychiatry Hospital, Poltava, Ukraine.
authors: Andrey
authors: A
authors: Scripnikov
authors: Alexander
authors: A
authors: Khomenko
authors: Oleksandr
authors: O
authors: Napryeyenko
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003704:Dementia / Q000175:diagnosis / Q000188:drug therapy*; D015140:Dementia, Vascular / Q000175:diagnosis / Q000188:drug therapy; D004311:Double-Blind Method; D015577:Geriatric Assessment; D020441:Ginkgo biloba; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D000096983:Ginkgo Extract
chemical_list: D002317:Cardiovascular Agents; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract
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