Glioperazine B, as a new antimicrobial agent against Staphylococcus aureus, and glioperazine C: two new dioxopiperazines from Bionectra byssicola.
In the course of our screening for new antibacterials from microbial metabolites, two new dioxopiperazine metabolites, glioperazines B (1) and C (2), together with the known compound, glioperazine (3), were isolated from the mycelia of a liquid fermentation culture of the fungus, Bionectra byssicola F120. The structures of compounds 1 and 2 were assigned on the basis of MS and NMR data. Compound 1 is an unusual dioxopiperazine metabolite containing an OMe group at the alpha-carbon of the amino acid residue. Compound 1 showed weak antibacterial activity against various strains of S. aureus, including methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), while 2 and 3 did not show such activity.
Zheng
Chang-Ji
CJ
Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Kim
Young-Ho
YH
Kim
Won-Gon
WG
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004351:Drug Resistance; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D026121:Indole Alkaloids; D010879:Piperazines; D015363:Quinolones; C524968:glioperazine B; C524969:glioperazine C; D008712:Methicillin