title: [Three-dimensional assessment of the remnant hepatic function following surgery using single photon emission computed tomography in an animal model].
abstract: OBJECTIVE
  The predictive value of postoperative hepatic function evaluated by liver functional imaging combined with single photon emission computed tomography (SPECT) technique was appraised in the present study.
  
  
  METHODS
  Twenty New Zealand white rabbits were divided randomly into two groups, including the Hepatic Fibrosis with Carcinoma Group (FC-Group, n = 10) and the Control Group (C-Group, n = 10). All the rabbits underwent the resection of outer-right lobe of the liver. The whole hepatic function indexes, such as HCI(5), HLI(5) and Ex(15), and the hepatic function remnant indexes, including HCI(5P), HLI(5P) and Ex(15P), were calculated by 99mTc-EHIDA liver imaging.
  
  
  RESULTS
  Ex(15) of FC-Group was lower than that of C-Group (P < 0.05). HCI(5) and HLI(5) of FC-Group had the trends to increase compared with the C-Group. Ex(15) was positively correlated with ALB, and negatively correlated with TBil and GGT (P < 0.05). HCI(5) had a positive correlation with CHE (P < 0.05), while HLI(5) had a negative correlation with A/G (P < 0.05). HLI(5P) had the negative correlation with postoperative A/G (P < 0.05), and Ex(15P) had the negative correlation with postoperative TBil and GGT (P < 0.05).
  
  
  CONCLUSIONS
  This study has established a method of 3-D liver function evaluation system on an animal model. Among the indexes, Ex(15) can exactly represent the whole liver function while Ex(15P) and HLI(5P) can predict the liver function after the liver resection. The results may help the future clinical use of this technique to evaluate the risk of operation.
authors: Department of Liver Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. maoy@public3.bta.net.cn
authors: Yi-lei
authors: YL
authors: Mao
authors: Tao
authors: T
authors: Zhang
authors: Xin-ting
authors: XT
authors: Sang
authors: Fang
authors: F
authors: Li
authors: Jian-tao
authors: JT
authors: Ba
authors: Xin
authors: X
authors: Lu
authors: Zhi-ying
authors: ZY
authors: Yang
authors: Shou-xian
authors: SX
authors: Zhong
authors: Jie-fu
authors: JF
authors: Huang
mesh_terms: D000818:Animals; D006498:Hepatectomy; D008099:Liver / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D008106:Liver Cirrhosis, Experimental / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D008111:Liver Function Tests; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D011184:Postoperative Period; D011817:Rabbits; D015899:Tomography, Emission-Computed, Single-Photon