Clinical characteristics of dementia associated with argyrophilic grain disease.
OBJECTIVE
We aimed at characterizing the clinical features of dementia associated with argyrophilic grain disease (AgD).


METHODS
Relatives or close friends of 24 individuals with autopsy-confirmed AgD and 29 patients with autopsy-confirmed Alzheimer's disease (AD) were administered a novel Retrospective Dementia Inventory to assess the cognitive, behavioral and affective symptoms of the deceased patients.


RESULTS
AgD patients showed less severe impairments in memory, language, attention and executive function than AD patients.


CONCLUSIONS
Compared to AD patients, individuals suffering from AgD appear to present with comparable deficits in behavior and affect but relatively spared cognitive functioning.
Steuerwald
Gertrud M
GM
Memory Clinic -- Neuropsychology Center, University Hospital Basel, Basel, Switzerland.
Baumann
Thomas P
TP
Taylor
Kirsten I
KI
Mittag
Michael
M
Adams
Heiner
H
Tolnay
Markus
M
Monsch
Andreas U
AU
D000339:Affect / Q000502:physiology; D000368:Aged; D000369:Aged, 80 and over; D001519:Behavior / Q000502:physiology; D001921:Brain / Q000473:pathology; D003071:Cognition / Q000502:physiology; D003704:Dementia / Q000209:etiology / Q000473:pathology / Q000523:psychology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000523:psychology*; D009483:Neuropsychological Tests; D010551:Personality; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D016875:tau Proteins / Q000502:physiology*
D016875:tau Proteins