Angiotensin II type 1 receptor blockade prevents decrease in adult stem-like cells in kidney after ureteral obstruction.
Infusion of renal side population (SP) cells, enriched with adult stem-like cells, can ameliorate acute renal failure. We investigated the effects of an angiotensin II type 1 (AT(1)) receptor antagonist, valsartan on SP cell changes in renal injury by ureteral obstruction. Renal SP fraction was reduced by 38%, and the number of cells expressing CD45, a marker of hematopoietic system, in renal SP cells was increased in obstructed kidneys. Valsartan attenuated renal injury and the associated SP profile changes. Angiotensin AT(1) receptor blockade may exert regenerative effect by preserving adult stem-like cells such as SP cells in the kidney.
Marumo
Takeshi
T
Department of Clinical Renal Regeneration, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655 Tokyo, Japan. tmarumo-npr@umin.ac.jp
Hishikawa
Keiichi
K
Matsuzaki
Yumi
Y
Imai
Naohiko
N
Takase
Osamu
O
Shimosawa
Tatsuo
T
Okano
Hideyuki
H
Fujita
Toshiro
T
D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005355:Fibrosis; D005434:Flow Cytometry; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D017493:Leukocyte Common Antigens / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D013234:Stem Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013777:Tetrazoles / Q000008:administration & dosage / Q000494:pharmacology; D014517:Ureteral Obstruction / Q000503:physiopathology*; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D000068756:Valsartan
D047228:Angiotensin II Type 1 Receptor Blockers; D013777:Tetrazoles; D000068756:Valsartan; D017493:Leukocyte Common Antigens; D014633:Valine