Microwave-assisted synthesis of substituted hexahydro-pyrrolo[3,2-c]quinolines.
New compounds with the ethyl hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate skeleton were prepared by microwave-assisted intramolecular 1,3-dipolar cycloaddition reactions. The reactions were carried out under solvent-free conditions and compared with the same reaction in the presence of a solvent and a catalyst. Steric effects on the selectivity of the reaction were noted and evaluated.
Neuschl
Michal
M
Department of Organic Chemistry, Masaryk University, Kotlarska 2, Brno, Czech Republic.
Bogdal
Darek
D
Potacek
Milan
M
D008872:Microwaves; D008958:Models, Molecular; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
D011758:Pyrroles; D011804:Quinolines; C037219:quinoline
J Org Chem. 2001 Jul 27;66(15):5113-23
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