title: Improvement of erectile function with Prelox: a randomized, double-blind, placebo-controlled, crossover trial.
abstract: In a randomly allocated, double-blind, placebo-controlled, crossover design, 50 patients with mild to moderate erectile dysfunction (ED) were treated for 1 month with placebo or a combination of L-arginine aspartate and Pycnogenol (Prelox). Patients reported sexual function from diaries. Testosterone levels and endothelial NO synthase (e-NOS) were monitored along with routine clinical chemistry. Intake of Pycnogenol for 1 month restored erectile function to normal. Intercourse frequency doubled. e-NOS in spermatozoa and testosterone levels in blood increased significantly. Cholesterol levels and blood pressure were lowered. No unwanted effects were reported. Prelox is a promising alternative to treat mild to moderate ED.
authors: Department of Obstetrics and Gynecology, Medical University Sofia, Faculty of Medicine, Sofia, Bulgaria.
authors: R
authors: R
authors: Stanislavov
authors: V
authors: V
authors: Nikolova
authors: P
authors: P
authors: Rohdewald
mesh_terms: D000328:Adult; D001120:Arginine / Q000494:pharmacology / Q000627:therapeutic use*; D001224:Aspartic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D010410:Penile Erection; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D013739:Testosterone / Q000097:blood*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D005419:Flavonoids; D018377:Neurotransmitter Agents; D010936:Plant Extracts; D014665:Vasodilator Agents; C553157:prelox; D001224:Aspartic Acid; D013739:Testosterone; C024070:pycnogenols; D001120:Arginine; D002784:Cholesterol; D019001:Nitric Oxide Synthase; C024891:arginine aspartate