[Small heat shock proteins--role in apoptosis, cancerogenesis and diseases associated with protein aggregation].
Small heat shock proteins (sHsps) belong to molecular chaperones, which protect prokaryotic and eukaryotic cells against deleterious effects, of stress. sHsps prevent stress induced, irreversible aggregation of damaged proteins and facilitate renaturation of bound substrates cooperating with other molecular chaperones. This review summarizes recent studies focused mainly on the involvement of sHsps in diseases related to protein aggregation. sHsps are often a component of protein aggregates forming during progress of neurodegenerative disorders. Mutation in sHsps genes have been identified, which are responsible for development of cataract, desmin related myopathy and neuropathies. sHsps protect cells against oxidative stress resulting from ischemia/reperfusion during heart or brain stroke. Several studies indicate that sHsp participate in regulation of apoptosis and are involved in cancerogenesis. Uncovering the sHsps role in diseases enable to develop new therapeutic strategies.
Laskowska
Ewa
E
Katedra Biochemii, Instytut Biologii, Uniwersytet Gdański, ul. Kładki 24, 80-952 Gdańsk. lasko@biotech.univ.gda.pl
D017209:Apoptosis / Q000502:physiology*; D014408:Biomarkers, Tumor; D002386:Cataract / Q000378:metabolism* / Q000503:physiopathology; D003459:Crystallins / Q000378:metabolism; D055551:HSP27 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000378:metabolism; D050888:Heat-Shock Proteins, Small / Q000378:metabolism*; D018869:Heat-Shock Response / Q000502:physiology; D018832:Molecular Chaperones / Q000378:metabolism; D015394:Molecular Structure; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D011489:Protein Denaturation; D017510:Protein Folding; D020673:Protein Renaturation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism
D014408:Biomarkers, Tumor; D003459:Crystallins; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; C442250:HSPB2 protein, human; C413214:HSPB8 protein, human; D006360:Heat-Shock Proteins; D050888:Heat-Shock Proteins, Small; D018832:Molecular Chaperones; D009363:Neoplasm Proteins; C086058:ODF1 protein, human; D017346:Protein Serine-Threonine Kinases