Huntington's disease and steroid hormone receptors.
BACKGROUND
Steroid hormone receptors constitute a special group of receptors having a wide range of efficiency and distribution in the body. Androgen and estrogen receptors, and their expression in the body, are linked with attributes such as reproduction control and sexual behaviour, but their relation with behavioural models, perception, memory and stress remain unclear to date.


OBJECTIVE
In this project we aim to focus on monitoring the expressive influence of steroid hormone receptors on embryonic tissues and subsequently, expand our study to include the expression on adult tissues such as the CNS and to monitor the developmental aspects and relations pertaining to neurodegenerative disorders, such as Huntington's disease.


METHODS
We shall rely on immuno-histochemistry, immuno-fluorescence and RT-PCR methods for detecting steroid hormone receptors and Huntingtin-associated protein 1 in the embryonic and adult tissue.


CONCLUSIONS
Mapping the expression of steroid receptors during development represents an essential step in the quest for further studies and monitoring of the expression in adult tissues.
Molikova
Radka
R
Department of Anatomy, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic. molikovaradka@yahoo.co.uk
Bezdickova
Marcela
M
David
Ondrej
O
Bebarova
Linda
L
D000328:Adult; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D002460:Cell Line; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism*; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*
C096896:HAP1 protein, human; D009419:Nerve Tissue Proteins; D011960:Receptors, Estrogen