Multiglandular parathyroid carcinoma: a case report and brief review.
A 53-year-old man with no past medical history was admitted with complaints of hematuria, flank and abdominal pain of one week duration. He also complained of an enlarging new neck mass one month before presentation. The laboratory assessment showed a calcium level of 17.3 mg/dL (normal 8.5-10.5 mg/dL), serum albumin 2.9 g/dL (normal 3.0-5.0 g/dL), serum creatinine 3.4 mg/dL (normal 0.5-1.2 mg/dL). A neck ultrasound showed a complicated left neck mass. He was hydrated for one week with improvement in his labs, showing a decrease in serum calcium to 9.3 mg/dL and a serum creatinine of1.8 mg/dL. He underwent a total thyroidectomy and parathyroidectomy. The pathology showed multiglandular parathyroid carcinoma. It is important for the physician and surgeon dealing with primary hyperparathyroidism to look for parathyroid carcinoma. A better knowledge and understanding of this condition would aid in early diagnosis and possibly increase the survival rate.
Sahasranam
Prem
P
Division of Endocrinology and Department of Pathology, Charles R. Drew University, 1731 East 120th Street, Los Angeles, CA 90059, USA. premsahasranam@yahoo.com
Tran
Michael T
MT
Mohamed
Hezla
H
Friedman
Theodore C
TC
D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D003404:Creatinine / Q000097:blood; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D016105:Parathyroidectomy / Q000379:methods; D012709:Serum Albumin / Q000032:analysis; D013965:Thyroidectomy / Q000379:methods; D016896:Treatment Outcome
D015415:Biomarkers; D010281:Parathyroid Hormone; D012709:Serum Albumin; D003404:Creatinine; D002118:Calcium