Intrathecal baclofen in the treatment of post-stroke central pain, dystonia, and persistent vegetative state.
Intrathecal baclofen (ITB) administration is a fully established treatment for severe spasticity. However, it is not widely known that baclofen, an agonist of the GABA-B receptor, has additional beneficial effects in other conditions such as chronic pain, coma, dystonia, tetanus, and hyypothalamic storm. Sporadic cases of dramatic recovery from persistent vegetative state after intrathecal administration of baclofen have been reported. There have been also reports on the use of baclofen for control of dystonia due to cerebral palsy, neuropathic central pain syndrome or reflex sympathetic dystrophy. On the other hand, epidural spinal cord stimulation (SCS) has been used in the management not only of pain but also of spasticity, dystonia, and in order to improve deteriorated consciousness, but the effects so far have been modest and variable. Similarities between ITB and SCS are interesting as both involve the spinal GABAergic system. Based on a 15-year personal experience of intrathecal baclofen, I would stress the importance of this treatment not only for spasticity but also for other difficult neurological disorders.
Taira
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Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Tokyo, Japan. ttaira@nij.twmu.ac.jp
Hori
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D001418:Baclofen / Q000627:therapeutic use*; D004421:Dystonia / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D018458:Persistent Vegetative State / Q000188:drug therapy* / Q000209:etiology; D020521:Stroke / Q000150:complications
D009125:Muscle Relaxants, Central; D001418:Baclofen