Twin pregnancy with a coexisting hydatiform mole and liveborn infant: complicated by maternal hyperthyroidism and neonatal hypothyroidism.
A twin pregnancy with a coexisting complete hydatiform mole and a healthy fetus is rare. Associated with this condition are potentially serious maternal and fetal complications. We describe a case of a woman, 23/40 pregnant, who was diagnosed with a twin pregnancy complicated by a hydatiform mole, vaginal bleeding, hyperthyroidism and preterm labour at 26/40. Her hyperthyroidism was successfully treated with propylthiouracil. The preterm labour resulted in the livebirth of a healthy male infant. The baby developed biochemical hypothyroidism post-natally. The baby's thyroid function tests were unexpected, revealing a low T4 and a low-normal thyroid stimulating hormone. This is the first case reported in the literature to describe an infant's clinical and biochemical thyroid status after gestational trophoblastic disease complicated by hyperthyroidism.
True
Deanna K
DK
Department of Paediatric Endocrinology, Mater Children's Hospital, Brisbane, Queensland, Australia. truenaidu@optusnet.com.au
Thomsett
Michael
M
Liley
Helen
H
Chitturi
Sridhar
S
Cincotta
Robert
R
Morton
Adam
A
Cotterill
Andrew
A
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole; D006980:Hyperthyroidism / Q000097:blood / Q000188:drug therapy*; D007037:Hypothyroidism / Q000097:blood / Q000150:complications*; D007231:Infant, Newborn; D050498:Live Birth; D008297:Male; D011247:Pregnancy; D011433:Propranolol / Q000627:therapeutic use; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use; D013960:Thyroid Function Tests; D016896:Treatment Outcome; D014427:Twins
D000319:Adrenergic beta-Antagonists; D013956:Antithyroid Agents; D011441:Propylthiouracil; D011433:Propranolol