Mangiferin identified in a screening study guided by neuraminidase inhibitory activity.
A screening study on neuraminidase inhibitory constituents was carried out, and activity-guided fractionations of three plants, Gouania obtusifolia, Zizyphus cambodiana, and Mangifera odorata, led to the isolation of eleven compounds (1-11). Mangiferin was identified as a significant neuraminidase inhibitor.
Li
Xiaofan
X
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Ohtsuki
Takashi
T
Shindo
Sayaka
S
Sato
Masaaki
M
Koyano
Takashi
T
Preeprame
Srisomporn
S
Kowithayakorn
Thaworn
T
Ishibashi
Masami
M
D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D031022:Mangifera; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D010946:Plants, Medicinal; D027823:Rhamnaceae; D044004:Xanthones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031957:Ziziphus
D004791:Enzyme Inhibitors; D010936:Plant Extracts; D044004:Xanthones; C013592:mangiferin; D009439:Neuraminidase