title: Mechanokinetic model of cell membrane: theoretical analysis of plasmalemma homeostasis, growth and division.
abstract: A theoretical model dealing with endocytosis, exocytosis and caveolae invagination, describing plasmalemma homeostasis during cell growth and division, is proposed. It considers transmembrane pressure, membrane tension and mechanosensitivity of membrane processes. Membrane hydraulic conductivity and the flux of transmembrane nonvesicular transport are taken into account. The developed mathematical analysis operates with a formulated set of constitutive equations describing the mechanical state and kinetics of changes in an open dynamic membrane system. The standard version of a model with adjusted parameters was implemented, and predictions including a discussion on the effect of possible parameter modifications were presented. Computer simulations indicate big changes in the magnitude of membrane tension and elasticity, and in the number of membrane buddings in young cells and during mitosis. They also show the extent of cell growth inhibition resulting from a decrease in transmembrane transport or an increase in the exerted difference in osmotic pressure. Moreover, the simulations reveal that exocytosis regulated during mitosis may not be as important for cell growth, as sometimes presumed. Finally, practical application and possible extension of the model are discussed.
authors: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warszawa, Poland. piotrp@ibb.waw.pl
authors: Piotr H
authors: PH
authors: Pawlowski
mesh_terms: D000818:Animals; D001692:Biological Transport; D002455:Cell Division / Q000502:physiology; D049108:Cell Enlargement; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D003198:Computer Simulation; D003593:Cytoplasm / Q000378:metabolism; D006706:Homeostasis; D008954:Models, Biological; D009997:Osmotic Pressure