GABAergic drugs for the treatment of migraine.
Within the last decades significant progress has been made in the understanding of the underlying pathophysiological mechanisms of migraine. There is a general agreement now that migraine is not only a vascular phenomenon but also a genetically determined heterogenic ion-channelopathy resulting in cortical-spreading-depression-like events, the temporary impairment of antinociceptive structures of the brainstem and the activation of the trigeminal-vascular system. The development and use of drugs targeting ion-channels and subsequently reducing cortical excitability appears as a promising avenue for both the acute treatment of migraine and migraine prevention. This review summarizes the current knowledge and evidence for GABAergic drugs in the treatment of migraine.
Puppe
Anja
A
Department of Neurology, Cologne City Hospitals, University of Cologne, Germany.
Limmroth
Volker
V
D000208:Acute Disease; D000588:Amines / Q000627:therapeutic use; D000818:Animals; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D005632:Fructose / Q000031:analogs & derivatives / Q000627:therapeutic use; D018682:GABA Agents / Q000627:therapeutic use*; D018756:GABA Antagonists / Q000627:therapeutic use; D000077206:Gabapentin; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000627:therapeutic use; D000069583:Pregabalin; D018079:Receptors, GABA / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D018080:Receptors, GABA-B / Q000187:drug effects / Q000502:physiology; D000077236:Topiramate; D014635:Valproic Acid / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000502:physiology* / Q000627:therapeutic use
D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D018682:GABA Agents; D018756:GABA Antagonists; D018696:Neuroprotective Agents; D018079:Receptors, GABA; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D000077236:Topiramate; D005632:Fructose; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D000077206:Gabapentin