title: Myxoinflammatory fibroblastic sarcoma: investigations by comparative genomic hybridization of two cases and review of the literature.
abstract: Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade sarcoma of the distal extremities characterized by a myxohyaline stroma, a dense inflammatory infiltrate and virocyte- and lipoblast-like giant cells. Up to now, only two cases have been investigated cytogenetically, showing complex and heterogeneous karyotypes, in part with supernumerary ring chromosomes. We characterized two further cases of MIFS immunohistochemically and performed comparative genomic hybridization as well as DNA image cytometry analyses. Both tumors showed the characteristic histomorphological pattern of MIFS and were positive for Vimentin and CD68. Moreover, both cases presented aberrant karyotypes including distinct DNA copy number changes involving chromosome 7 and disclosed DNA aneuploidy.
authors: Institute of Pathology, University of Basel, Schönbeinstrasse 40, 4003 Basel, Switzerland. dbaumhoer@mac.com
authors: Daniel
authors: D
authors: Baumhoer
authors: Kathrin
authors: K
authors: Glatz
authors: Hans-Jürgen
authors: HJ
authors: Schulten
authors: László
authors: L
authors: Füzesi
authors: Renato
authors: R
authors: Fricker
authors: Christoph
authors: C
authors: Kettelhack
authors: Paula
authors: P
authors: Hasenboehler
authors: Martin
authors: M
authors: Oberholzer
authors: Gernot
authors: G
authors: Jundt
mesh_terms: D000368:Aged; D005260:Female; D005385:Fingers; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009693:Nucleic Acid Hybridization; D012516:Osteosarcoma / Q000235:genetics* / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000235:genetics* / Q000473:pathology; D020429:Tibial Neuropathy / Q000235:genetics* / Q000473:pathology
references: Virchows Arch. 2001 May;438(5):509-12
references: 11407481
references: Am J Surg Pathol. 1998 Aug;22(8):911-24
references: 9706971
references: Mod Pathol. 1998 Apr;11(4):384-91
references: 9578090
references: Genes Chromosomes Cancer. 1994 Aug;10(4):231-43
references: 7522536
references: Anal Quant Cytol Histol. 1998 Aug;20(4):302-12
references: 9739413
references: Clin Orthop Relat Res. 2006 Apr;445:254-60
references: 16446594
references: Anal Cell Pathol. 1998;17(4):189-200
references: 10391371
references: Anal Cell Pathol. 1998;17(4):201-8
references: 10391372
references: Ann Diagn Pathol. 2002 Oct;6(5):272-80
references: 12376919
references: Pathologe. 2001 Mar;22(2):157-61
references: 11321733
references: Pathol Int. 2002 Sep;52(9):595-606
references: 12406189
references: Pathol Res Pract. 1998;194(8):529-33
references: 9779486
references: Virchows Arch. 2003 Jan;442(1):25-30
references: 12536311
references: Cancer Genet Cytogenet. 2004 Jul 1;152(1):61-5
references: 15193443
references: Pathol Res Pract. 2002;198(9):639-42
references: 12440787
references: Cytopathology. 2003 Apr;14(2):73-8
references: 12713479