title: Endovascular cooling in a patient with neuroleptic malignant syndrome.
abstract: We report a case of severe neuroleptic malignant syndrome with hyperthermia, rhabdomyolysis and hepatic failure where we applied endovascular cooling in order to reverse hyperthermia. After rapid normalization of core temperature at 37.5 degrees C, the patient's condition improved and CK levels dropped. However, upon withdrawl of endovascular temperature control there was a relapse. This is the first case where endovascular cooling was applied successfully in neuroleptic malignant syndrome.
authors: Department of Neurology, University of Heidelberg, Germany. jennifer.diedler@med.uni-heidelberg.de
authors: Jennifer
authors: J
authors: Diedler
authors: Patricio
authors: P
authors: Mellado
authors: Roland
authors: R
authors: Veltkamp
mesh_terms: D014150:Antipsychotic Agents / Q000506:poisoning; D002408:Catheters, Indwelling; D003402:Creatine Kinase / Q000097:blood; D004357:Drug Synergism; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy*; D006220:Haloperidol / Q000506:poisoning*; D006634:Histamine H1 Antagonists / Q000506:poisoning; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000503:physiopathology; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000150:complications* / Q000503:physiopathology*; D011398:Promethazine / Q000506:poisoning*; D012008:Recurrence; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000503:physiopathology; D013406:Suicide, Attempted; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D006634:Histamine H1 Antagonists; D003402:Creatine Kinase; D011398:Promethazine; D006220:Haloperidol