Scientific evidence for a fixed extract combination (Ze 91019) from valerian and hops traditionally used as a sleep-inducing aid.
Valerian and hops are traditionally used as sleep-inducing aids. Alertness reduces gradually with the prolongation of wakefulness through the release of endogenous adenosine in the frontal basal cortex. Valerian has an adenosine-like action and supports the readiness to fall asleep. The control of the sleep-wake rhythm induces sleep when the time-related interaction is operating properly. The control is closely related to endogenous melatonin secretion. Hops act in a similar way to melatonin. Therefore, the efficacy of a valerian and hops combination in sleep disorder can scientifically be explained.
Brattström
Axel
A
Max Zeller Söhne AG, Romanshorn, Switzerland. Axel.Brattstroem@ZellerAG.ch
D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004338:Drug Combinations; D006801:Humans; D027582:Humulus / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D028321:Plant Preparations; D051381:Rats; D012893:Sleep Wake Disorders / Q000188:drug therapy*; D014632:Valerian / Q000737:chemistry
D004338:Drug Combinations; D010936:Plant Extracts; D028321:Plant Preparations
Phytother Res. 2007 Sep;21(9):847-51
17486686
Arch Int Pharmacodyn Ther. 1994 Mar-Apr;327(2):220-31
7979830
Planta Med. 2006 Jun;72(7):579-83
16673319
Mol Pharmacol. 2006 Feb;69(2):640-9
16272224
Phytomedicine. 2004 Nov;11(7-8):633-8
15636177
Neurochem Res. 1999 Nov;24(11):1373-8
10555777
Neuroscience. 2000;101(3):523-9
11113301
J Ethnopharmacol. 2007 Jan 3;109(1):87-92
16920300
J Nat Prod. 2002 Oct;65(10):1479-85
12398547
Life Sci. 2002 Sep 6;71(16):1939-49
12175708
Biochem Pharmacol. 2007 Jan 15;73(2):248-58
17097622
Planta Med. 2004 Jul;70(7):594-7
15254851
Eur J Med Res. 2006 Nov 30;11(11):496-500
17182362
Brain Res Mol Brain Res. 2005 Aug 18;138(2):191-7
15921820
Phytother Res. 2006 Sep;20(9):794-8
16819753
J Neuroendocrinol. 2003 Apr;15(4):432-7
12622846
J Pharm Pharmacol. 2007 Apr;59(4):549-52
17430638
Planta Med. 2006 Jun;72(7):656-8
16636971
Eur J Med Res. 2000 Sep 18;5(9):385-90
11003973
Phytomedicine. 2006 Sep;13(8):535-41
16860977
J Ethnopharmacol. 2005 Oct 31;102(1):102-6
16046089
Sleep Med Rev. 2002 Aug;6(4):321-32
12531135