title: [Association between serum adiponectin and mean blood pressure].
abstract: OBJECTIVE
  To investigate the relationship between serum adiponectin and mean blood pressure (BP).
  
  
  METHODS
  A total of 187 subjects were divided into four groups according to BP levels: optimal blood pressure group (n = 38), high normal blood pressure group (n = 50), treated hypertension group (n = 54) and untreated hypertension group (n = 45). Serum adiponectin and microalbuminuria were detected by radioimmunology assay. Insulin resistant index defined as HOMA-IR and urinary concentration of microalbuminuria/urinary concentration of creatinine defined as albumin creatinine ratio (ACR) were calculated.
  
  
  RESULTS
  (1) Serum adiponectin decreased in proportion to BP increase and the serum adiponectin level was significantly higher in treated hypertension group than untreated hypertension group. (2) Correlation analysis showed that adiponectin concentration was negatively correlated with mean blood pressure (P < 0.01). (3) Multivariate regression analysis revealed that mean blood pressure and HOMA-IR were independent predictors of serum adiponectin level.
  
  
  CONCLUSIONS
  Mean blood pressure was the main determinant of serum adiponectin level and negatively correlated to serum adiponectin level.
authors: Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. xinli3267@yeah.net
authors: Xin-Li
authors: XL
authors: Li
authors: Min
authors: M
authors: Tong
authors: Qiong
authors: Q
authors: Xu
authors: Xin-Zheng
authors: XZ
authors: Lu
authors: Zhen-Zhen
authors: ZZ
authors: Wang
authors: Yan-Li
authors: YL
authors: Zhou
authors: Hai-Feng
authors: HF
authors: Zhang
authors: Ke-Jiang
authors: KJ
authors: Cao
authors: Jun
authors: J
authors: Huang
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010808:Physical Examination / Q000706:statistics & numerical data
chemical_list: D052242:Adiponectin