Innate immune response triggers lupus-like autoimmune disease.
Autoimmune disease is typically defined as an aberrant response of lymphocytes to self antigens that ultimately leads to tissue damage. Reporting in Immunity, Green et al. (2007) now show that mice lacking alpha-mannosidase II develop an autoimmune disease similar to lupus. Remarkably, this illness is precipitated by an innate immune response to altered self glycans that mimic molecular patterns found on pathogens.
Paulson
James C
JC
Departments of Chemical Physiology and Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92014, USA.
D000375:Aging / Q000502:physiology; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D018398:Homeodomain Proteins / Q000235:genetics; D007113:Immunity, Innate; D007136:Immunoglobulins / Q000008:administration & dosage / Q000494:pharmacology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000473:pathology; D050606:Mannose-Binding Protein-Associated Serine Proteases / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D008363:alpha-Mannosidosis / Q000235:genetics
D018398:Homeodomain Proteins; D007136:Immunoglobulins; C064658:RAG-1 protein; D050606:Mannose-Binding Protein-Associated Serine Proteases