Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease.
The development of safe and effective antigen-specific therapies is needed to treat patients with autoimmune diseases. These therapies must allow for the specific tolerization of self-reactive immune cells without altering host immunity to infectious insults. Experimental models and clinical trials for the treatment of autoimmune disease have identified putative mechanisms by which antigen-specific therapies induce tolerance. Although advances have been made in the development of efficient antigen-specific therapies, translating these therapies from bench to bedside has remained difficult. Here, we discuss the recent advances in our understanding of antigen-specific therapies for the treatment of autoimmune diseases.
Miller
Stephen D
SD
Department of Microbiology-Immunology and Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. miller@northwestern.edu
Turley
Danielle M
DM
Podojil
Joseph R
JR
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000517:prevention & control / Q000628:therapy*; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy / Q000379:methods*; D051379:Mice; D010455:Peptides / Q000276:immunology / Q000627:therapeutic use*
D001324:Autoantigens; D010455:Peptides