title: The role of N-beta-alanyldopamine synthase in the innate immune response of two insects.
abstract: Insects trigger a multifaceted innate immune response to fight microbial infections. We show that in the yellow mealworm, Tenebrio molitor, septic injuries induce the synthesis of N-beta-alanyldopamine (NBAD), which is known as the main sclerotization precursor of insect brown cuticles. We demonstrate that NBAD synthase is induced in the epidermis of the mealworm and of the Medfly, Ceratitis capitata, by infection with Escherichia coli. Our results indicate that synthesis of NBAD seems to be a novel component of the overall innate immune response in insects.
authors: Department of Biological Chemistry, FCEyN, University of Buenos Aires, IIBBA-CONICET and Fundación Instituto Leloir, Patricias Argentinas 435, Buenos Aires 1405, Argentina.
authors: Julieta
authors: J
authors: Schachter
authors: Martín M
authors: MM
authors: Pérez
authors: Luis A
authors: LA
authors: Quesada-Allué
mesh_terms: D000818:Animals; D033622:Ceratitis capitata / Q000201:enzymology* / Q000276:immunology*; D004298:Dopamine / Q000031:analogs & derivatives*; D004790:Enzyme Induction; D004817:Epidermis / Q000201:enzymology; D004926:Escherichia coli / Q000502:physiology; D007113:Immunity, Innate / Q000276:immunology*; D019476:Insect Proteins / Q000378:metabolism; D007814:Larva / Q000382:microbiology; D008025:Ligases / Q000276:immunology / Q000378:metabolism*; D013712:Tenebrio / Q000201:enzymology* / Q000276:immunology*; D013997:Time Factors
chemical_list: D019476:Insect Proteins; C038990:N(beta)-alanyldopamine; D008025:Ligases; C460159:catecholamine-beta-alanyl ligase; D004298:Dopamine