title: Decreased antioxidant vitamin concentration may be a risk factor for recurrent carotid stenosis.
abstract: Carotid endarterectomy has been found to be associated with a transient increase in systemic oxidative stress, and this has been shown to be a predictor of restenosis. The aim of this study was to determine the incidence of early recurrent stenosis and investigate a possible role of oxidative stress in its development by measuring the concentration of antioxidant vitamins. Patients undergoing carotid endarterectomy between August 2001 and February 2003 were included in the study. A preoperative blood sample was analyzed for antioxidant vitamin concentrations. All patients were followed up by duplex scans 3 and 12 months postoperatively. Ninety-three patients (101 carotid endarterectomies) were recruited. Nine arteries had developed restenosis by 12 months. Those patients who developed recurrent stenosis had significantly lower vitamin C concentrations (19.10 +/- 3.69 vs 30.11 +/- 19.10, P = .02) than those who did not. This study suggests that low antioxidant vitamin levels may predispose to early restenosis after carotid endarterectomy.
authors: Regional Vascular and Endovascular Unit, Belfast City Hospital, Belfast, Northern Ireland. julieann.reid@virgin.net
authors: Julie A
authors: JA
authors: Reid
authors: Louis L
authors: LL
authors: Lau
authors: Raymond J
authors: RJ
authors: Hannon
authors: Bernard
authors: B
authors: Lee
authors: Ian S
authors: IS
authors: Young
authors: Chee V
authors: CV
authors: Soong
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D016893:Carotid Stenosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000601:surgery*; D002851:Chromatography, High Pressure Liquid; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D018709:Statistics, Nonparametric; D024505:Tocopherols / Q000097:blood; D014463:Ultrasonography
chemical_list: D000975:Antioxidants; D001205:Ascorbic Acid; D024505:Tocopherols