[Effects of volatile organic compounds on brain amino acid neurotransmitter in mice].
OBJECTIVE
Study adverse effects of volatile organic compounds volatile organic compounds (VOCs) on brain amino acid neurotransmitter in mice.


METHODS
Four groups of mouse were respectively exposed to 0, low, middle and high concentration of VOCs for two hours every day for 30 days. The content of brain amino acid neurotransmitter was determined.


RESULTS
The result showed that the content of Glu and ASP in brain of VOCs -exposed mouse decreased and GABA and Gly increased compared with that of control.


CONCLUSIONS
The memory impair in mice induced by exposing VOCs may relate to the chang of content of amino acid neurotransmitter.
Zhang
Huanzhu
H
School of Public Health, Fudan University, Shanghai 200032, China.
Song
Weimin
W
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D008297:Male; D051379:Mice; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011897:Random Allocation; D055549:Volatile Organic Compounds / Q000633:toxicity*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D018377:Neurotransmitter Agents; D055549:Volatile Organic Compounds; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid