title: Coordination of copper with aspirin enhances its anti-platelet aggregation activity.
abstract: Anti-platelet aggregation of copper aspirinate, a copper complex of aspirin, has been studied in vitro and in vivo. The result shows that copper aspirinate is much more effective than aspirin against AA-, ADP- and PAF-induced platelet aggregation. Its mechanism is related to the inhibition of platelet cyclooxygenase and release of active substances from platelets, and to the promotion of PGI(2) level in plasma.
authors: Institute of Precious Metals, 650221, Kunming.
authors: L
authors: L
authors: Weiping
authors: Y K
authors: YK
authors: Yang
authors: H Z
authors: HZ
authors: Xiong
authors: X Z
authors: XZ
authors: Cheng
authors: Z H
authors: ZH
authors: Chen
authors: Z Q
authors: ZQ
authors: Shen
authors: L
authors: L
authors: Li
references: J Med Chem. 1976 Jan;19(1):135-48
references: 1246036
references: Nature. 1962 Jun 9;194:927-9
references: 13871375
references: Prog Med Chem. 1989;26:437-568
references: 2690187