A water-soluble "switching on" fluorescent chemosensor of selectivity to Cd2+.
Compound 1, a new fluorescent chemosensor signaling via significantly enhanced fluorescence when bound with cation analytes, was synthesized and characterized. This fluorescent chemosensor exhibits its selectivity to Cd2+ among a series of cations in HEPES buffer solution. Its in vitro sensitivity to Cd2+ was demonstrated in the HK-2 cell line with use of confocal microscopy. The mechanistic selectivity and sensitivity of compound 1 to Cd2+ was discussed on the basis of fluorescence, 1H NMR, and mass spectroscopic results.
Liu
Weimin
W
Laboratory of Organic Optoelectronic Functional Materials and Molecular Engineering, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100080, China.
Xu
Liwei
L
Sheng
Ruilong
R
Wang
Pengfei
P
Li
Huaping
H
Wu
Shikang
S
D002104:Cadmium / Q000737:chemistry* / Q000494:pharmacology; D002412:Cations / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012995:Solubility; D013053:Spectrophotometry; D014867:Water / Q000737:chemistry*
D002412:Cations; D005456:Fluorescent Dyes; D002104:Cadmium; D014867:Water