title: A psychometric evaluation of the CDRS and MADRS in assessing depressive symptoms in children.
abstract: OBJECTIVE
  This study compared the psychometric properties of the Children's Depression Rating Scale-Revised (CDRS-R) and the Montgomery-Asberg Depression Rating Scale (MADRS) in children with major depressive disorder.
  
  
  METHODS
  Children (N = 96; ages 8 to 11 years inclusive) with nonpsychotic major depressive disorder were enrolled. Participants were part of a multisite, outpatient, randomized, placebo-controlled, 9-week trial of fluoxetine (10 mg/day for the first week and 20 mg/day thereafter). The CDRS-R and MADRS were completed based on clinician interviews with both parents and children. Classic test theory and item response theory analyses were conducted.
  
  
  RESULTS
  The MADRS and CDRS-R total scores were correlated at baseline (r = 0.51) and at study exit (r = 0.85). Cronbach's alpha was .86 (CDRS-R) and .82 (MADRS) at exit. The effect sizes for change from baseline to exit between the fluoxetine and placebo groups were 0.78 (CDRS-R) and 0.61 (MADRS). There was agreement between the CDRS-R and MADRS in the declaration of treatment response (50% improvement from baseline to exit) in 84.2% of children. Test information function favored the CDRS-R.
  
  
  CONCLUSIONS
  The CDRS-R showed greater effect size for differentiating drug and placebo and better test information than the MADRS in this study of depressed children.
authors: Drs. Jain, Trivedi, Hughes, Morris, and Emslie are with the Department of Psychiatry and Drs. Carmody and Rush are with the Departments of Psychiatry and Clinical Sciences at The University of Texas Southwestern Medical Center at Dallas; and Dr. Bernstein is with The University of Texas at Arlington.
authors: Shailesh
authors: S
authors: Jain
authors: Drs. Jain, Trivedi, Hughes, Morris, and Emslie are with the Department of Psychiatry and Drs. Carmody and Rush are with the Departments of Psychiatry and Clinical Sciences at The University of Texas Southwestern Medical Center at Dallas; and Dr. Bernstein is with The University of Texas at Arlington.
authors: Thomas J
authors: TJ
authors: Carmody
authors: Drs. Jain, Trivedi, Hughes, Morris, and Emslie are with the Department of Psychiatry and Drs. Carmody and Rush are with the Departments of Psychiatry and Clinical Sciences at The University of Texas Southwestern Medical Center at Dallas; and Dr. Bernstein is with The University of Texas at Arlington.
authors: Madhukar H
authors: MH
authors: Trivedi
authors: Drs. Jain, Trivedi, Hughes, Morris, and Emslie are with the Department of Psychiatry and Drs. Carmody and Rush are with the Departments of Psychiatry and Clinical Sciences at The University of Texas Southwestern Medical Center at Dallas; and Dr. Bernstein is with The University of Texas at Arlington.
authors: Carroll
authors: C
authors: Hughes
authors: Drs. Jain, Trivedi, Hughes, Morris, and Emslie are with the Department of Psychiatry and Drs. Carmody and Rush are with the Departments of Psychiatry and Clinical Sciences at The University of Texas Southwestern Medical Center at Dallas; and Dr. Bernstein is with The University of Texas at Arlington.
authors: Ira H
authors: IH
authors: Bernstein
authors: Drs. Jain, Trivedi, Hughes, Morris, and Emslie are with the Department of Psychiatry and Drs. Carmody and Rush are with the Departments of Psychiatry and Clinical Sciences at The University of Texas Southwestern Medical Center at Dallas; and Dr. Bernstein is with The University of Texas at Arlington.
authors: David W
authors: DW
authors: Morris
authors: Drs. Jain, Trivedi, Hughes, Morris, and Emslie are with the Department of Psychiatry and Drs. Carmody and Rush are with the Departments of Psychiatry and Clinical Sciences at The University of Texas Southwestern Medical Center at Dallas; and Dr. Bernstein is with The University of Texas at Arlington.
authors: Graham J
authors: GJ
authors: Emslie
authors: Drs. Jain, Trivedi, Hughes, Morris, and Emslie are with the Department of Psychiatry and Drs. Carmody and Rush are with the Departments of Psychiatry and Clinical Sciences at The University of Texas Southwestern Medical Center at Dallas; and Dr. Bernstein is with The University of Texas at Arlington.. Electronic address: john.rush@utsouthwestern.edu.
authors: A John
authors: AJ
authors: Rush
mesh_terms: D002648:Child; D003863:Depression / Q000175:diagnosis* / Q000188:drug therapy* / Q000523:psychology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011594:Psychometrics; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors
references: J Am Acad Child Adolesc Psychiatry. 1998 Sep;37(9):915-23
references: 9735611
references: J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
references: 14399272
references: Psychol Bull. 2006 Jan;132(1):132-49
references: 16435960
references: Eur Neuropsychopharmacol. 2006 Dec;16(8):601-11
references: 16769204
references: Psychol Assess. 2000 Sep;12(3):354-9
references: 11021160
references: J Child Adolesc Psychopharmacol. 2001 Winter;11(4):341-76
references: 11838819
references: J Affect Disord. 2002 Aug;70(3):313-7
references: 12128243
references: J Am Acad Child Adolesc Psychiatry. 2002 Oct;41(10):1205-15
references: 12364842
references: J Affect Disord. 2003 Sep;76(1-3):127-35
references: 12943942
references: Br J Soc Clin Psychol. 1967 Dec;6(4):278-96
references: 6080235
references: Biometrics. 1977 Mar;33(1):159-74
references: 843571
references: Br J Psychiatry. 1979 Apr;134:382-9
references: 444788
references: Br J Psychiatry. 1982 Jul;141:45-9
references: 7116071
references: J Abnorm Child Psychol. 1982 Sep;10(3):307-24
references: 7175040
references: J Am Acad Child Psychiatry. 1984 Mar;23(2):191-7
references: 6715741
references: Am J Psychiatry. 1985 Oct;142(10):1168-73
references: 4037128
references: J Abnorm Child Psychol. 1987 Mar;15(1):91-113
references: 3571741
references: J Child Psychol Psychiatry. 1987 Jul;28(4):613-24
references: 3654810
references: Arch Gen Psychiatry. 1997 Nov;54(11):1031-7
references: 9366660