Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy.
Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer domain in cancer treatment.
Giordano
Antonio
A
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg., Philadelphia, Pennsylvania 19122, USA. giordsno@temple.edu
Rossi
Alessandra
A
Romano
Gaetano
G
Bagella
Luigi
L
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D049109:Cell Proliferation; D016147:Genes, Tumor Suppressor; D006801:Humans; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D017434:Protein Structure, Tertiary; D050717:Retinoblastoma-Like Protein p130 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
C493837:RBL2 protein, human; D050717:Retinoblastoma-Like Protein p130