title: Occurence of stromal myofibroblasts in the invasive ductal breast cancer tissue is an unfavourable prognostic factor.
abstract: BACKGROUND
  Numerous experimental studies have described the capacity of myofibroblasts to stimulate mammary cancer cells in a paracrine manner. Until now, the prognostic significance of myofibroblasts present in breast cancer has not been examined.
  
  
  METHODS
  In paraffin sections, originating from 45 patients with primary invasive breast cancer, immunohistochemical reactions were performed using antibodies directed against smooth muscle actin, Ki-67, VEGF, bFGF and UPA.
  
  
  RESULTS
  The cases with higher content of myofibroblasts in the tumour tissue manifested higher grade, more pronounced expression of Ki-67, VEGF and bFGF and shorter overall survival and relapse-free survival.
  
  
  CONCLUSIONS
  The present study for the first time documents the unfavourable prognostic significance of myofibroblasts in tissues of invasive ductal mammary carcinomas.
authors: Institute of Pathology, Charité Campus Mitte, Charitéplatz 1, D-10117, Germany.
authors: Pawel
authors: P
authors: Surowiak
authors: Dawid
authors: D
authors: Murawa
authors: Verena
authors: V
authors: Materna
authors: Adam
authors: A
authors: Maciejczyk
authors: Marek
authors: M
authors: Pudelko
authors: Slawomir
authors: S
authors: Ciesla
authors: Jan
authors: J
authors: Breborowicz
authors: Pawel
authors: P
authors: Murawa
authors: Maciej
authors: M
authors: Zabel
authors: Manfred
authors: M
authors: Dietel
authors: Hermann
authors: H
authors: Lage
mesh_terms: D000199:Actins / Q000096:biosynthesis; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008875:Middle Aged; D032446:Myoblasts / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D014568:Urokinase-Type Plasminogen Activator / Q000096:biosynthesis; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
chemical_list: D000199:Actins; D019394:Ki-67 Antigen; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D014568:Urokinase-Type Plasminogen Activator