title: Positron emission tomography in the staging of patients with Hodgkin's lymphoma. A prospective multicentric study by the Intergruppo Italiano Linfomi.
abstract: In this prospective multicentric study, we investigated the contribution of positron emission tomography (PET) scanning to the staging of Hodgkin's lymphoma (HL) by computed tomography (CT) and attempted to determine whether it has any impact on therapeutic approach. One hundred eighty six consecutive patients with HL from six Italian centers were enrolled in this study. They were staged with conventional methods; 2-[fluorine-18]fluoro-2-deoxy-D: -glucose PET scanning were prospectively compared to CT. CT and FDG-PET stages were concordant in 156 patients (84%) and discordant in 30 patients (16%). PET stage in comparison to CT stage was higher in 27 patients (14%) and lower in 3 patients (1%). The programmed treatment strategy was modified in 11 out of 30 patients (37%) after the definition of final stage. If we considered the 123 CT staged patients with localized stage, ten patients (8%) with a change of stage from localized to advanced after PET evaluation were treated with different strategy. FDG-PET was shown to be a relevant, non-invasive method that supplements conventional procedures and should therefore be used routinely to stage HL, particularly in early stage patients, where a change in stage may modify disease management.
authors: Hematology and Nuclear Medicine, Careggi Hospital and University of Florence, Florence, Italy. l.rigacci@dac.unifi.it
authors: Luigi
authors: L
authors: Rigacci
authors: Umberto
authors: U
authors: Vitolo
authors: Luca
authors: L
authors: Nassi
authors: Francesco
authors: F
authors: Merli
authors: Andrea
authors: A
authors: Gallamini
authors: Patrizia
authors: P
authors: Pregno
authors: Isabel
authors: I
authors: Alvarez
authors: Flavia
authors: F
authors: Salvi
authors: Rosaria
authors: R
authors: Sancetta
authors: Antonio
authors: A
authors: Castagnoli
authors: Annibale
authors: A
authors: Versari
authors: Alberto
authors: A
authors: Biggi
authors: Michele
authors: M
authors: Gregianin
authors: Ettore
authors: E
authors: Pelosi
authors: Teodoro
authors: T
authors: Chisesi
authors: Alberto
authors: A
authors: Bosi
authors: Alessandro
authors: A
authors: Levis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000000981:diagnostic imaging; D019468:Disease Management; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006689:Hodgkin Disease / Q000000981:diagnostic imaging*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18