title: Motor neuron disease associated with non-fluent rapidly progressive aphasia: case report and review of the literature.
abstract: The superimposed clinical features of motor neuron disease (MND) and frontotemporal lobar degeneration (FTLD) comprise a rare neurological overlap syndrome that represents a diagnostic challenge to neurologists. Currently, FTLD-MND is considered a distinct entity and its clinicopathological basis has recently been reviewed. Our aim is to present a patient with MND and non-fluent rapidly progressive aphasia with clinical, imaging and histopathological correlation, as well as a brief review of the literature. We demonstrated the selective corticospinal tract (CST) and temporal lobe involvement using T1 spin-echo with an additional magnetization transfer contrast pulse on resonance (T1 SE/MTC) and FLAIR MR sequences in our patient, with further clinical and histopathological correlation. To the best of our knowledge, there is no description about the use of these particular MR sequences in the evaluation of FTLD-MND patients.
authors: Division of Neuroradiology, Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil. antonio.rocha@fleury.com.br
authors: A J
authors: AJ
authors: da Rocha
authors: B C O
authors: BC
authors: Valério
authors: R P
authors: RP
authors: Buainain
authors: M E
authors: ME
authors: Ferraz
authors: C J
authors: CJ
authors: da Silva
authors: A C M
authors: AC
authors: Maia
authors: V P
authors: VP
authors: Andrade
authors: C L P
authors: CL
authors: Lancellotti
mesh_terms: D001039:Aphasia, Broca / Q000150:complications* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000150:complications* / Q000473:pathology