title: First-line liver resection and salvage liver transplantation are increasing therapeutic strategies for patients with hepatocellular carcinoma and child a cirrhosis.
abstract: OBJECTIVE
  The present study focused on nine patients with hepatocellular carcinoma (HCC) associated with Child A liver cirrhosis undergoing first-line liver resection and salvage liver transplantation (SLT) for liver tumor recurrence.
  
  
  METHODS
  Forty-six patients with HCC underwent liver transplantation (OLT); 37 (80.5%) were primary liver transplantations (PLTs) and 9 (19.5%) were SLTs. All patients who underwent SLT received minor transabdominal liver resections.
  
  
  RESULTS
  The posttransplant 1-, 3-, and 5-year overall survival rates for SLT (88.9%, 88.9%, and 88.9%) were similar to those for PLT (78%, 62.7%, and 62.7%). Four (10.8%) patients in the PLT group had HCC recurrence, while there was zero recurrence in the SLT group. The 1-, 3-, 5-year disease-free survival rates for PLT (89%, 74%, and 74%) were similar to those for SLT (100%, 100%, and 100%). The 1-, 3-, 5-year disease-free survival rates after PLT were 89%, 74%, and 74%, and after SLT were 100%, 100%, and 100%, respectively. The operative mortality, intraperioperative bleeding, operative time, intensive care unit stay, in-hospital stay, and overall incidence of postoperative complications were similar in the two groups.
  
  
  CONCLUSIONS
  In our experience, SLT for HCC is a feasible procedure with similar results in terms of overall survival, disease-free survival, and postoperative complications to those reported for patients who underwent PLT at our institute. An important role exists for SLT as shown by the fact that such a strategy has been used in the 20% of the patients undergoing OLT for HCC.
authors: Division of Surgical Oncology and Liver Transplantation, Regina Elena Cancer Institute, Rome, Italy. vennarecci@ifo.it
authors: G
authors: G
authors: Vennarecci
authors: G M
authors: GM
authors: Ettorre
authors: M
authors: M
authors: Antonini
authors: R
authors: R
authors: Santoro
authors: M
authors: M
authors: Maritti
authors: G
authors: G
authors: Tacconi
authors: D
authors: D
authors: Spoletini
authors: L
authors: L
authors: Tessitore
authors: L
authors: L
authors: Perracchio
authors: G
authors: G
authors: Visco
authors: C
authors: C
authors: Puoti
authors: E
authors: E
authors: Santoro
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000601:surgery*; D008103:Liver Cirrhosis / Q000601:surgery*; D008113:Liver Neoplasms / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality / Q000706:statistics & numerical data*; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011336:Probability; D016019:Survival Analysis