title: Association of plasma adiponectin levels with oxidative stress in hemodialysis patients.
abstract: BACKGROUND
  Recent evidence suggests that oxidative stress may be an instigator of the metabolic syndrome, and adiponectin, an adipocyte-derived polypeptide, may modulate oxidative stress, ameliorating the atherosclerotic process.
  
  
  OBJECTIVE
  Oxidative stress is increased in hemodialysis (HD) patients. We hypothesize that a relationship between plasma levels of adiponectin and markers of inflammation and oxidative stress exists.
  
  
  RESULTS
  In 124 HD patients, plasma adiponectin levels and three separate oxidative stress markers, tumor necrosis factor-alpha as well as high-sensitivity C-reactive protein (hsCRP) were determined. Plasma adiponectin was significantly and negatively correlated with serum hsCRP (r = -0.247, p = 0.008) and plasma malondialdehyde (MDA) levels (r = -0.326; p < 0.001). Multiple regression analyses suggested that plasma MDA, serum HDL cholesterol levels and logarithmically transformed hsCRP were the variables independently associated with plasma adiponectin levels.
  
  
  CONCLUSIONS
  Plasma adiponectin was significantly associated with plasma MDA, serum HDL cholesterol levels and serum hsCRP levels. Our results suggest the possibility that plasma adiponectin may play a role in alleviating oxidative stress in HD patients.
authors: Department of Food Nutrition, Providence University, Taichung, Taiwan, ROC.
authors: Paik-Seong
authors: PS
authors: Lim
authors: Shun-Liang
authors: SL
authors: Chen
authors: Ming-Ying
authors: MY
authors: Wu
authors: Chuen-Yuh
authors: CY
authors: Hu
authors: Tsai-Kun
authors: TK
authors: Wu
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000502:physiology; D000328:Adult; D000368:Aged; D015415:Biomarkers; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007333:Insulin Resistance; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D018384:Oxidative Stress; D006435:Renal Dialysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D002097:C-Reactive Protein