IL-13 receptor isoforms: breaking through the complexity.
Interleukin (IL)-13 is an immunoregulatory cytokine secreted predominantly by activated T-helper type 2 (Th2) cells, and it has been identified as crucial in developing allergic inflammatory responses. Its diverse functions are mediated by a complex receptor system including IL-4 receptor alpha (IL-4Ralpha; CD124) and two other cognate cell surface proteins, IL-13Ralpha1 (CD213a1) and IL-13Ralpha2 (CD213a2). IL-13Ralpha1 forms a heterodimer with IL-4Ralpha that is a signaling IL-13 receptor. In contrast, IL-13Ralpha2 has been thought to be a decoy receptor due to its short cytoplasmic tail. IL-13Ralpha2 exists on the cell membrane, intracellularly, and in soluble form. Recent reports revealed that membrane IL-13Ralpha2 may have some signaling capabilities, and soluble IL-13Ralpha2 is a critical endogenous modulator for IL-13 responses. The receptor has more complicated functions than a simple decoy receptor. In this review, we describe the isoforms of IL-13Ralpha2 and discuss newly revealed functions of IL-13Ralpha2.
Tabata
Yasuhiro
Y
Division of Allergy and Immunology, Institute for Personalized and Predictive Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Khurana Hershey
Gurjit K
GK
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D004194:Disease; D006801:Humans; D053663:Interleukin-13 Receptor alpha2 Subunit / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D020033:Protein Isoforms / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D053660:Receptors, Interleukin-13 / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014018:Tissue Distribution; D014158:Transcription, Genetic
D053663:Interleukin-13 Receptor alpha2 Subunit; D020033:Protein Isoforms; D053660:Receptors, Interleukin-13
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