title: Update on HIV lymphoma.
abstract: In industrialized nations people infected with HIV remain at increased risk for malignancies despite highly active antiretroviral therapy. In these countries, lymphoma is the most common HIV-associated malignancy. This review summarizes progress from January 2005 to February 2007. The majority of investigation has been in diffuse large B cell lymphoma, with infusional therapy remaining promising but cumbersome. Rituximab likely improves complete response rates, and, possibly overall survival, but is likely associated with increased infections in a subset of patients with very low CD4 counts. Biologic insights have been attained in the spectrum of HIV-associated non-Hodgkin's lymphoma, Hodgkin's lymphoma, and virologic coinfections. Overall, the outcome for non-Hodgkin's lymphoma and Hodgkin's lymphoma in the setting of HIV continues to improve as insights into the pathophysiology and treatment advance.
authors: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10064, USA. noya@mskcc.org
authors: Ariela
authors: A
authors: Noy
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy / Q000821:virology; D011379:Prognosis
chemical_list: D044966:Anti-Retroviral Agents
references: N Engl J Med. 1993 Sep 30;329(14 ):987-94
references: 8141877
references: Exp Hematol. 2005 Apr;33(4):487-94
references: 15781340
references: Blood. 2005 Nov 1;106(9):3166-74
references: 16014568
references: Blood. 2004 Jan 1;103(1):275-82
references: 14504078
references: Blood. 2006 Jan 1;107(1):13-20
references: 16099881
references: Br J Cancer. 2006 Dec 4;95(11):1598-602
references: 17106439
references: Clin Lymphoma Myeloma. 2006 Mar;6(5):399-402
references: 16640817
references: Clin Infect Dis. 2006 Feb 15;42(4):e21-5
references: 16421782
references: Ann Hematol. 2005 Oct;84(10):661-6
references: 15875183
references: J Clin Oncol. 2005 Jul 1;23(19):4430-8
references: 15883411
references: Blood. 1997 Feb 15;89(4):1413-20
references: 9028965
references: Blood. 2005 Jan 15;105(2):496-502
references: 15358629
references: Am J Surg Pathol. 2005 Dec;29(12):1633-41
references: 16327436
references: Ann Intern Med. 2005 Aug 16;143(4):265-73
references: 16103470
references: Clin Infect Dis. 2005 Apr 1;40(7):1022-7
references: 15824995
references: AIDS Res Hum Retroviruses. 2005 Mar;21(3):214-20
references: 15795527
references: AIDS. 2005 Oct 14;19(15):1711-2
references: 16184051
references: Blood. 2003 Jun 15;101(12):4653-9
references: 12609827
references: J Clin Oncol. 2006 Sep 1;24(25):4123-8
references: 16896005
references: Cancer. 2002 Mar 1;94(5):1492-9
references: 11920506
references: Cancer. 2003 Sep 15;98(6):1196-205
references: 12973843
references: Blood. 2006 Apr 1;107(7):3014-5
references: 16554492
references: AJNR Am J Neuroradiol. 2005 Sep;26(8):1973-9
references: 16155145
references: J Clin Oncol. 2000 Oct 1;18(19):3325-30
references: 11013271
references: Transplantation. 2005 Sep 15;80(5):673-82
references: 16177644
references: Blood. 2001 Dec 15;98(13):3857-9
references: 11739198
references: Blood. 2006 Apr 15;107(8):3412-4
references: 16597601
references: J Clin Oncol. 2005 Nov 1;23(31):8116-7
references: 16258111
references: Br J Dermatol. 2005 Oct;153(4):828-32
references: 16181470
references: Blood. 2005 Mar 1;105(5):1891-7
references: 15550484
references: Ann Oncol. 2004 Nov;15(11):1673-9
references: 15520070
references: Int J Cancer. 2005 Aug 10;116(1):161-3
references: 15756687
references: J Acquir Immune Defic Syndr. 2005 Jul 1;39(3):293-9
references: 15980688
references: Blood. 2006 May 15;107(10):3832-40
references: 16410446
references: Eur J Haematol. 2005 Jan;74(1):70-2
references: 15613110
references: Nature. 2000 Feb 3;403(6769):503-11
references: 10676951
references: J Clin Oncol. 2005 Jul 1;23(19):4372-80
references: 15994147
references: Blood. 2007 Apr 15;109(8):3214-8
references: 17209054
references: Leuk Lymphoma. 2005 Feb;46(2):207-15
references: 15621803
references: Blood. 2005 Sep 1;106(5):1538-43
references: 15914552
references: J Clin Oncol. 2005 Nov 1;23(31):8132-3; author reply 8133-4
references: 16258119
references: Leukemia. 2005 May;19(5):851-5
references: 15744337
references: HIV Med. 2005 Jan;6(1):21-6
references: 15670248
references: Blood. 2005 Sep 1;106(5):1762-9
references: 15905193
references: Haematologica. 2005 Jul;90(7):990-2
references: 15996943
references: Blood. 2006 Dec 1;108(12):3786-91
references: 16917006
references: Clin Infect Dis. 2006 Feb 1;42(3):411-7
references: 16392091
references: Cell Res. 2005 Nov-Dec;15(11-12):947-52
references: 16354573
references: J Cell Biol. 2003 Jun 9;161(5):839-43
references: 12796473
references: Virology. 2005 Nov 10;342(1):38-46
references: 16122775
references: J Clin Oncol. 2003 Dec 1;21(23):4423-7
references: 14581441
references: J Clin Oncol. 2005 Nov 20;23(33):8477-82
references: 16230675