title: Treatment outcomes in patients with signet ring cell carcinoma of the colorectum.
abstract: BACKGROUND
  The aim of this study was to evaluate the clinicopathologic features and prognosis of signet ring cell (SRC) carcinoma and compare them with those of mucinous and poorly differentiated adenocarcinomas of the colorectum.
  
  
  METHODS
  The clinicopathologic data of 35 patients with primary SRC carcinoma were reviewed and compared with the data from 294 patients with mucinous and 252 patients with poorly differentiated adenocarcinoma.
  
  
  RESULTS
  Eighty percent of the SRC patients presented with more advanced disease (stages III and IV), whereas 55.1% and 64.7% of the patients in the mucinous and poorly differentiated groups had advanced disease at diagnosis, respectively (80% vs 55.1%, P = .04 and 80.0% vs 64.7%, P = .437). Median survival time for patients with SRC was 18.4 months (95% confidence interval 10.4 to 19.6). Three- and 5-year survival rates in the SRC group were 33.7% and 25.3%, respectively. The overall survival rate of patients with SRC was significantly poorer than that of patients with mucinous or poorly differentiated adenocarcinoma (P < .001).
  
  
  CONCLUSIONS
  SRC of the colorectum is characterized by advanced stage at diagnosis with lower rates of curative resection. It tends to affect younger patients with more propensity for lymphovascular invasion.
authors: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, Korea 135-710.
authors: Won-Suk
authors: WS
authors: Lee
authors: Ho-Kyung
authors: HK
authors: Chun
authors: Woo Yong
authors: WY
authors: Lee
authors: Seong Hyeon
authors: SH
authors: Yun
authors: Yong Beom
authors: YB
authors: Cho
authors: Hae-Ran
authors: HR
authors: Yun
authors: Sang-Hui
authors: SH
authors: Park
authors: Sang Yong
authors: SY
authors: Song
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery*; D002288:Adenocarcinoma, Mucinous / Q000473:pathology* / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology* / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome