Cell tracking using magnetic resonance imaging.
Cell tracking by in vivo magnetic resonance imaging (MRI) requires strategies of labelling the cells with MRI contrast agents. The principal routes to achieve efficient cell labelling for neurological applications are discussed with methodological advantages and caveats. Beyond temporo-spatial localization of labelled cells, the investigation of functional cell status is of great interest to allow studies of functional cell dynamics. The two major approaches to reach this goal, use of responsive contrast agents and generation of transgenic cell lines, are discussed.
Hoehn
Mathias
M
In-vivo-NMR Laboratory, Max-Planck-Institute for Neurological Research, Gleueler Strasse 50, D-50931 Köln, Germany. mathias@nf.mpg.de
Wiedermann
Dirk
D
Justicia
Carles
C
Ramos-Cabrer
Pedro
P
Kruttwig
Klaus
K
Farr
Tracy
T
Himmelreich
Uwe
U
D000818:Animals; D002468:Cell Physiological Phenomena; D003287:Contrast Media; D005290:Ferric Compounds; D008264:Macrophages / Q000502:physiology; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles; D009474:Neurons / Q000502:physiology; D013194:Staining and Labeling / Q000379:methods*; D020521:Stroke / Q000276:immunology
D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15256-61
10611372
Stroke. 2007 Jan;38(1):90-5
17138950
Nat Biotechnol. 2000 Mar;18(3):321-5
10700150
Magn Reson Med. 2001 Nov;46(5):1018-22
11675656
Nat Biotechnol. 2001 Dec;19(12):1141-7
11731783
NMR Biomed. 2002 Jun;15(4):278-83
12112610
Neuroimage. 2002 Oct;17(2):803-11
12377155
Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16267-72
12444255
Ann Neurol. 2003 Feb;53(2):259-63
12557295
Magn Reson Med. 2003 Jul;50(1):201-5
12815696
Magn Reson Med. 2003 Oct;50(4):767-76
14523963
J Cereb Blood Flow Metab. 2003 Nov;23(11):1356-61
14600443
Neuroimage. 2004 Jan;21(1):311-7
14741669
NMR Biomed. 2004 Jun;17(4):163-9
15229929
Magn Reson Med. 2004 Aug;52(2):403-6
15282824
Neoplasia. 2005 Feb;7(2):109-17
15802016
Nat Med. 2005 Apr;11(4):450-4
15778721
Magn Reson Med. 2005 Jul;54(1):59-66
15968679
Mol Imaging. 2005 Apr-Jun;4(2):104-9
16105508
Mol Imaging. 2005 Jul-Sep;4(3):143-64
16194447
AJNR Am J Neuroradiol. 2006 May;27(5):1000-5
16687532
Neuroimage. 2006 Sep;32(3):1150-7
16814567
Neuroimage. 2006 Sep;32(3):1142-9
16815042
Nat Med. 2000 Mar;6(3):351-5
10700241