Psychosocial influences on immunity, including effects on immune maturation and senescence.
Studies investigating the influence of psychosocial factors on immunity played a critical and formative role in the field of psychoneuroimmunology (PNI), and have been a major component of articles published in Brain, Behavior and Immunity (BBI). An analysis of papers during the first two decades of BBI from 1987-2006 revealed three behavior-related topics were most prominent: (1) stress-induced changes in immune responses, (2) immune correlates of psychopathology and personality, and (3) behavioral conditioning of immunity. Important subthemes included the effect of early rearing conditions on immune maturation in the developing infant and, subsequently, psychosocial influences affecting the decline of immunity in the senescent host. The responsiveness of cell functioning in the young and elderly helped to validate the view that our immune competence is malleable. Many technical advances in immune methods were also evident. Initially, there was a greater reliance on in vitro proliferative and cytolytic assays, while later studies were more likely to use cell subset enumerations, cytokine quantification, and indices of latent virus reactivation. The reach of PNI extended from the traditional clinical entities of infection, autoimmunity, and cancer to attain a broader relevance to inflammatory physiology, and thus to asthma, cardiovascular and gastrointestinal disease. There continue to be many theoretical and applied ramifications of these seminal findings. Fortunately, the initial controversies about whether psychological processes could really impinge upon and modify immune responses have now receded into the pages of history under the weight of the empirical evidence.
Coe
Christopher L
CL
Department of Psychology, Harlow Center for BioPsychology, University of Wisconsin, 22 North Charter Street, Madison, WI 53715, USA. ccoe@wisc.edu
Laudenslager
Mark L
ML
D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D011584:Psychology; D011598:Psychoneuroimmunology / Q000266:history*; D011643:Publishing / Q000266:history / Q000639:trends; D013312:Stress, Physiological / Q000276:immunology* / Q000503:physiopathology; D013315:Stress, Psychological / Q000276:immunology
Brain Behav Immun. 2003 Feb;17 Suppl 1:S73-83
12615190
Brain Behav Immun. 1993 Dec;7(4):279-92
8280922
Brain Behav Immun. 1987 Mar;1(1):98-104
3451784
Arch Gen Psychiatry. 1964 Dec;11:657-74
14215982
Brain Behav Immun. 1996 Sep;10(3):288-97
8954600
Brain Behav Immun. 1999 Jun;13(2):138-54
10373278
Brain Behav Immun. 1998 Mar;12(1):1-6
9570857
Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1319-24
17229839
Brain Behav Immun. 2002 Dec;16(6):774-84
12480506
Brain Behav Immun. 2003 Feb;17(1):3-12
12615044
Brain Behav Immun. 2006 Mar;20(2):99-112
16307866
Nature. 1968 Nov 23;220(5169):821-2
5698765
Brain Behav Immun. 1997 Mar;11(1):1-8
9193763
Behav Cogn Neurosci Rev. 2004 Jun;3(2):114-30
15537988
Brain Behav Immun. 1987 Dec;1(4):356-60
3453209
Lancet. 1977 Apr 16;1(8016):834-6
67339
Brain Behav Immun. 2002 Dec;16(6):785-98
12480507
Behav Neural Biol. 1982 Sep;36(1):40-8
7168729
Brain Behav Immun. 1988 Jun;2(2):92-101
3148338
Brain Behav Immun. 1998 Jun;12(2):123-33
9646937
Brain Behav Immun. 1999 Jun;13(2):80-92
10373274
Brain Behav Immun. 1996 Jun;10(2):164-81
8811938
Brain Behav Immun. 2002 Oct;16(5):575-80
12401471
Brain Behav Immun. 1988 Jun;2(2):151-60
3233358
Brain Behav Immun. 1995 Mar;9(1):61-9
7620211
Brain Behav Immun. 2006 May;20(3):261-9
16293394
Brain Behav Immun. 1991 Jun;5(2):219-32
1654167
Brain Behav Immun. 2005 Jul;19(4):296-308
15944068
Brain Behav Immun. 1999 Mar;13(1):61-72
10371678
Brain Behav Immun. 1998 Sep;12(3):242-6
9769159
Brain Behav Immun. 1988 Jun;2(2):87-91
3233360
Brain Behav Immun. 1987 Mar;1(1):7-20
2837297
J Pediatr Gastroenterol Nutr. 2004 Apr;38(4):414-21
15085020
Brain Behav Immun. 1993 Mar;7(1):36-46
8471798
Psychol Bull. 1985 Sep;98(2):310-57
3901065
Brain Behav Immun. 2000 Mar;14(1):41-8
10729216
Brain Behav Immun. 1991 Jun;5(2):193-205
1654166
Brain Behav Immun. 1997 Jun;11(2):107-18
9299060
Brain Behav Immun. 2001 Mar;15(1):7-24
11259077
Brain Behav Immun. 1998 Mar;12(1):74-9
9570863
Brain Behav Immun. 2001 Dec;15(4):411-20
11782107
Brain Behav Immun. 2002 Feb;16(1):1-16
11846437
Dev Psychobiol. 1983 Jul;16(4):251-67
6411507
Brain Behav Immun. 2002 Dec;16(6):622-53
12480495
Brain Behav Immun. 1999 Jun;13(2):93-108
10373275
Brain Behav Immun. 1998 Mar;12(1):64-73
9570862
Brain Behav Immun. 1991 Sep;5(3):262-73
1954403
Brain Behav Immun. 2001 Sep;15(3):199-226
11566046
Brain Behav Immun. 2003 Apr;17(2):69-85
12676570
Brain Behav Immun. 1988 Jun;2(2):161-5
3233359