A new triterpenoid from roots of Laportea crenulata and its antifungal activity.
A new triterpenoid 2alpha,3beta,21beta,23,28-penta hydroxyl 12-oleanene and two known compounds were isolated from the roots of Laportea crenulata Gaud. The structures of all compounds were elucidated on the basis of various spectroscopic data. The two known compounds beta-sitosterol and beta-sitosterol 3-beta-D-glucopyranoside are also the first report of isolation from this plant. The antifungal activity of new triterpenoid was studied against Aspergillus flavus, Aspergillus niger, Candida albicans, and Rhizopus aurizae, and compared with the activity of nystatin (30 microg disc(-1)). This compound has shown moderate activity against tested fungi.
Khan
Alam
A
Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh.
Haque
Ekramul
E
Rahman
M Mukhlesur
MM
Mosaddik
Ashik
A
Rahman
Motiur
M
Sultana
Nasim
N
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry*; D001459:Bangladesh; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009761:Nystatin / Q000494:pharmacology; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D027003:Urticaceae / Q000737:chemistry*
C523931:2alpha,3beta,21beta,23,28-pentahydroxyl 12-oleanene; D000935:Antifungal Agents; D009761:Nystatin; D009828:Oleanolic Acid