MicroRNAs repress translation of m7Gppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylation.
Standart
Nancy
N
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.
Jackson
Richard J
RJ
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D039642:Eukaryotic Initiation Factors / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D066298:In Vitro Techniques; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D010442:Peptide Chain Initiation, Translational; D014176:Protein Biosynthesis; D012314:RNA Cap Analogs / Q000378:metabolism; D012315:RNA Caps / Q000235:genetics* / Q000378:metabolism*; D014714:Vertebrates / Q000235:genetics / Q000378:metabolism
D039642:Eukaryotic Initiation Factors; D035683:MicroRNAs; D012314:RNA Cap Analogs; D012315:RNA Caps; C017516:7-methylguanosine triphosphate