[Etiological agent and pathogenicity mechanism of PML].
JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML) that occurs mainly in immunosuppressed patients, especially those with HIV/AIDS. JCV belongs to the Polyomavirus that are characterized by non-enveloped icosahedral capsids containing small, circular, double-stranded DNA genomes. JCV is widely distributed among the population world-wide. However, infections are usually restricted by the immune system. In this article we briefly provide an overview of the interaction between JCV and host immunity. We also review the biological and physical characteristics and the lifecycle, receptors interaction, intracellular trafficking, viral transcription and replication, progeny virus propagation of JCV to examine the pathogenicity mechanism of PML.
Suzuki
Tadaki
T
Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control.
Nagashima
Kazuo
K
Sawa
Hirofumi
H
D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology; D053487:DEAD-box RNA Helicases / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D016867:Immunocompromised Host; D007577:JC Virus / Q000472:pathogenicity*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology; D054334:Viral Regulatory and Accessory Proteins; D000086082:Viroporin Proteins
D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone; D053487:DEAD-box RNA Helicases; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C118711:LZTS1 protein, human; C042559:agnoprotein, polyomavirus; D000086082:Viroporin Proteins; C086252:DDX1 protein, human