title: Expression of VE-Cadherin in Peritubular Endothelial Cells during Acute Rejection after Human Renal Transplantation.
abstract: Genes involved in acute rejection (AR) after organ transplantation remain to be further elucidated. In a previous work we have demonstrated the under-expression of VE-Cadherin by endothelial cells (EC) in AR following murine and human heart transplantation. Serial sections from 15 human kidney Banff-graded transplant biopsies were examined for the presence of VE-Cadherin and CD34 staining by immunohistochemistry (no AR (n = 5), AR grade IA (n = 5), or AR grade IIA (n = 5)). Quantification of peritubular EC staining were evaluated and results were expressed by the percentage of stained cells per surface analysed. There was no difference in CD34 staining between the 3 groups. VE-Cadherin expression was significantly reduced in AR Grade IIA when compared to no AR (P = .01) and to AR grade IA (P = .02). This study demonstrates a reduced VE-Cadherin expression by EC in AR after renal transplantation. The down-regulation of VE-Cadherin may strongly participate in human AR.
authors: INSERM U331/EA 3740, Faculté de Médecine RTH Laennec, 8 rue Guillaume Paradin, 69003 Lyon, France.
authors: Ana
authors: A
authors: Roussoulières
authors: Brigitte
authors: B
authors: McGregor
authors: Lara
authors: L
authors: Chalabreysse
authors: Catherine
authors: C
authors: Cerutti
authors: Jeanne-Luce
authors: JL
authors: Garnier
authors: Pascale
authors: P
authors: Boissonnat
authors: Olivier
authors: O
authors: Bastien
authors: Jean-Yves
authors: JY
authors: Scoazec
authors: Françoise
authors: F
authors: Thivolet-Bejui
authors: Laurent
authors: L
authors: Sebbag
authors: John
authors: J
authors: L McGregor
references: J Exp Med. 1990 Jun 1;171(6):2147-52
references: 2351935
references: Am J Physiol Renal Physiol. 2003 Aug;285(2):F191-8
references: 12684225
references: Cell Mol Life Sci. 1998 Sep;54(9):965-78
references: 9791539
references: Cell Regul. 1991 Apr;2(4):261-70
references: 2059658
references: J Cell Biol. 1990 May;110(5):1745-56
references: 2335569
references: Thromb Haemost. 2004 Jul;92(1):140-50
references: 15213855
references: Lancet. 1994 Apr 2;343(8901):831-6
references: 7908081
references: FASEB J. 1995 Jul;9(10):910-8
references: 7615160
references: J Cell Biol. 1992 Sep;118(6):1511-22
references: 1522121
references: Annu Rev Physiol. 1995;57:827-72
references: 7778885
references: J Cell Biol. 1991 Feb;112(3):479-90
references: 1899416
references: J Cell Biol. 1996 Oct;135(2):497-510
references: 8896605
references: Transplantation. 1984 Sep;38(3):293-8
references: 6591602
references: Kidney Int. 1999 Feb;55(2):713-23
references: 9987096
references: Transplantation. 1986 Jun;41(6):776-80
references: 2424159
references: Am J Pathol. 1992 Sep;141(3):673-83
references: 1519671
references: Am J Pathol. 1990 Sep;137(3):643-51
references: 2399935
references: Blood. 2001 Mar 15;97(6):1679-84
references: 11238107
references: Cell. 1991 Dec 20;67(6):1033-6
references: 1760836
references: Ann Surg. 1999 Jul;230(1):105-13
references: 10400043
references: N Engl J Med. 1989 Feb 9;320(6):365-76
references: 2536474
references: J Immunol. 2001 Aug 15;167(4):2323-30
references: 11490021
references: Circulation. 2001 Sep 18;104(12 Suppl 1):I319-24
references: 11568076
references: Cell. 1994 Jan 28;76(2):301-14
references: 7507411
references: J Cell Biol. 1995 Apr;129(1):203-17
references: 7698986
references: Circulation. 2005 May 24;111(20):2636-44
references: 15897346