title: Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family.
abstract: Reversible phosphorylation of cytoskeletal and cytoskeleton-associated proteins is a significant element of endothelial barrier function regulation. Therefore, understanding the mechanisms of phosphorylation/dephosphorylation of endothelial cell cytoskeletal proteins is vital to the treatment of severe lung disorders such as high permeability pulmonary edema. In vivo, there is a controlled balance between the activities of protein kinases and phosphatases. Due to various external or internal signals, this balance may be shifted. The actual balances at a given time alter the phosphorylation level of certain proteins with appropriate physiological consequences. The latest information about the structure and regulation of different types of Ser/Thr protein phosphatases participating in the regulation of endothelial cytoskeletal organization and barrier function will be reviewed here.
authors: Department of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, Illinois, USA.
authors: Csilla
authors: C
authors: Csortos
authors: Irina
authors: I
authors: Kolosova
authors: Alexander D
authors: AD
authors: Verin
mesh_terms: D000818:Animals; D002199:Capillary Permeability / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology* / Q000648:ultrastructure*; D042783:Endothelial Cells / Q000378:metabolism* / Q000648:ultrastructure*; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000502:physiology*
chemical_list: D010749:Phosphoprotein Phosphatases