Insulin: a model system for nanomedicine?
One of the predominant aims of insulin therapy for diabetes is to appropriately mimic physiological insulin secretion levels and their correlation with glucose concentration in healthy individuals. This report outlines current methods and their limitations in glycemic control and their possible relationship to insufficient knowledge about the structure and dynamics of the insulin hormone itself. Based on recent experimental and computational work, a possible approach to less-invasive insulin administration is sketched.
Koch
Manuela
M
Department of Chemistry, University of Basel, Basel, Switzerland.
Schmid
Franziska F-F
FF
Zoete
Vincent
V
Meuwly
Markus
M
D000818:Animals; D003198:Computer Simulation; D019281:Dimerization; D006801:Humans; D007328:Insulin / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008958:Models, Molecular; D050997:Nanomedicine / Q000379:methods* / Q000639:trends; D053758:Nanoparticles / Q000737:chemistry
D007328:Insulin