Meniscal allografts: indications and outcomes.
Meniscal allograft transplantation was introduced into clinical practice now over 20 years ago for the treatment of the symptomatic postmeniscectomy patient who has not yet developed osteoarthritis. Over the years, the indications have been fine-tuned and certain risk factors for failure have been identified. As the number of publications increases steadily, we now know that meniscal allografting significantly reduces pain and improves function. Recent data also suggest a potential chondroprotective effect in a subpopulation of patients. However, the major drawback in all meniscus allograft studies is the general lack of a control population. To improve our knowledge, future prospective studies should include objective outcome tools to evaluate the status of the allograft in addition to the clinical scoring systems. Future research should focus to elucidate the biologic and cellular processes involved in graft repopulation and remodelation.
Verdonk
René
R
Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, Ghent, Belgium. rene.verdonk@ugent.be
Almqvist
Karl F
KF
Huysse
Wouter
W
Verdonk
Peter C
PC
D001265:Athletic Injuries / Q000601:surgery*; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D008592:Menisci, Tibial / Q000637:transplantation*; D016378:Tissue Transplantation; D014184:Transplantation, Homologous; D016896:Treatment Outcome