Antiplatelet effects of acidamides isolated from the fruits of Piper longum L.
The inhibitory effects of four acidamides, piperine, pipernonaline, piperoctadecalidine, and piperlongumine, isolated from the fruits of Piper longum L. on washed rabbit platelet aggregation were examined. All of the four tested acidamides showed dose-dependent inhibitory activities on washed rabbit platelet aggregation induced by collagen, arachidonic acid (AA), and platelet-activating factor (PAF), except for that induced by thrombin. Piperlongumine, in particular, showed stronger inhibitory effects than other acidamides to rabbit platelet aggregation induced by collagen, AA and PAF.
Park
B-S
BS
Institute of Ecological Phytochemistry, Hankyong National University, Ansung City, Kyonggi-Do 456-749, Republic of Korea.
Son
D-J
DJ
Park
Y-H
YH
Kim
T W
TW
Lee
S-E
SE
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D008297:Male; D031701:Piper / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits
D000577:Amides; D010975:Platelet Aggregation Inhibitors