title: Clinicopathologic features of re-resected cases of intraductal papillary mucinous neoplasms (IPMNs).
abstract: BACKGROUND
  We analyzed the clinical characteristics and patterns of recurrence of intraductal papillary mucinous neoplasms (IPMNs) from 100 consecutive surgical cases.
  
  
  METHODS
  The average age was 62 +/- 12 years. The tumor was located in the head in 65 patients, body in 25 patients, and tail in 10 patients. Sixty-seven patients had benign IPMNs, and 33 patients had malignant IPMNs. Malignant IPMNs were observed more frequently in the head (42%) as compared with the body (20%) or tail (10%) (P < .05). During the follow-up period, 5 patients recurred and underwent second operation. In the first operation, 1 patient underwent pancreatoduodenectomy for the head tumor and the other 4 patients underwent distal pancreatectomy for the body and/or tail tumor.
  
  
  RESULTS
  Although histopathologic findings in the first operation were adenoma in 2 and carcinoma in 3 patients, all patients developed carcinoma by the time of the second operation. No hyperplasia developed recurrence. The overall recurrence rate for the head tumors was 1.5% (1 out of 65), whereas that for the body and tail tumors was 11.4% (4 out of 35) (P < .05). Metachronous multicentric recurrence was suspected in 4 cases.
  
  
  CONCLUSIONS
  These results indicate that adenomatous or carcinomatous IPMNs, especially originated from the body or tail, should be carefully observed even with a histologically negative surgical margin.
authors: Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Japan. yyoko@med.nagoya-u.ac.jp
authors: Yukihiro
authors: Y
authors: Yokoyama
authors: Masato
authors: M
authors: Nagino
authors: Koji
authors: K
authors: Oda
authors: Hideki
authors: H
authors: Nishio
authors: Tomoki
authors: T
authors: Ebata
authors: Tetsuya
authors: T
authors: Abe
authors: Tsuyoshi
authors: T
authors: Igami
authors: Yuji
authors: Y
authors: Nimura
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000236:Adenoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D002291:Carcinoma, Papillary / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate