Dendrimeric poly(propylene-imines) as effective delivery agents for DNAzymes: toxicity, in vitro transfection and in vivo delivery.
Tack
F
F
Oncology Discovery Research and Early Development, Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium. ftack@prdbe.jnj.com <ftack@prdbe.jnj.com>
Bakker
A
A
Maes
S
S
Dekeyser
N
N
Bruining
M
M
Elissen-Roman
C
C
Janicot
M
M
Janssen
H M
HM
De Waal
B F M
BF
Fransen
P M
PM
Lou
X
X
Meijer
E W
EW
Arien
A
A
Brewster
M E
ME
D045744:Cell Line, Tumor; D004247:DNA / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D021881:DNA, Catalytic / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D050091:Dendrimers / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D016259:Genes, myc; D006801:Humans; D009841:Oligonucleotides / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D011126:Polypropylenes / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D014162:Transfection / Q000379:methods*
D021881:DNA, Catalytic; D050091:Dendrimers; D009841:Oligonucleotides; D011126:Polypropylenes; C443641:poly(propyleneimine); D004247:DNA