Cell-based therapy for retina degeneration: the promise of a cure.
Cell-based therapies in the retina have been associated with the recovery of visual function in animal models of retinal degeneration. This review covers the current status of such therapies with regard to the source of the donor cells, their integration, and their impact on the degenerating host retina. Emphasis is also put on the importance of a careful interpretation of what is meant by "recovery of visual function". Two main approaches are considered here: (1) the use of human embryonic stem cell derived retinal pigment epithelial (RPE) cells to rescue photoreceptors in an animal model of RPE defect; and (2) the use of photoreceptor precursors to repair the degenerating neural retina. The current conclusions are that major hurdles have to be dealt with, such as finding an appropriate and ethically compliant donor cell source that would yield protracted survival and integration of the replacement retinal cells, and that there is no evidence yet that cell-based therapies can allow the long-term preservation or recovery of conscious vision.
Gaillard
Frédéric
F
Institut de Physiologie et Biologie Cellulaires, UMR 6187 CNRS, Université de Poitiers, Poitiers, France.
Sauvé
Yves
Y
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D020419:Photoreceptor Cells, Vertebrate / Q000166:cytology / Q000637:transplantation; D010857:Pigment Epithelium of Eye / Q000166:cytology / Q000637:transplantation*; D051381:Rats; D012162:Retinal Degeneration / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*; D016896:Treatment Outcome