title: Seven-year prospective study of nonmelanoma skin cancer incidence in U.K. renal transplant recipients.
abstract: Nonmelanoma skin cancer (NMSC) causes significant morbidity and mortality posttransplantation. We examined the annual incidence of NMSC in U.K. renal transplant recipients (RTRs). A total of 269 (95% of potential population) RTRs of skin type I-IV were recruited into a prospective study of NMSC incidence between 1998 and 2006. A total of 244 (91% enrolled) RTRs were screened on at least one occasion. The mean incidence per year of NMSC was 7.82% (SD: 1.84), comprising a mean (SD) incidence per year of squamous cell carcinoma 3.45% (1.36), basal cell carcinoma 3.58% (1.17), and Bowen's disease 2.52% (0.91). The risk of developing NMSC increased with duration posttransplantation: the mean incidence per year of NMSC was 3.27% (0.53) in RTRs <5 years posttransplantation, 5.86% (3.1) in RTRs 5-10 years posttransplant, and 11.1% (1.85) in those >10 years posttransplant. Relatively low NMSC incidence rates within the first 5 years posttransplantation suggests that duration posttransplantation may determine the optimum frequency of surveillance of RTRs in the United Kingdom.
authors: Department of Dermatology, Royal Hallamshire Hospital, Sheffield, South Yorkshire, United Kingdom.
authors: Helen M
authors: HM
authors: Ramsay
authors: Sarah M
authors: SM
authors: Reece
authors: Anthony A
authors: AA
authors: Fryer
authors: Andrew G
authors: AG
authors: Smith
authors: Paul N
authors: PN
authors: Harden
mesh_terms: D001913:Bowen's Disease / Q000453:epidemiology*; D002280:Basal Cell Carcinoma / Q000453:epidemiology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D015331:Cohort Studies; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation; D011446:Prospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology*; D006113:United Kingdom / Q000453:epidemiology