title: Proteoglycan biosynthesis during chondrogenic differentiation of mesenchymal stem cells.
abstract: Mesenchymal stem cells are multipotent progenitor cells that can differentiate into the chondrogenic lineage. To date, only limited knowledge about the formation and remodeling of the cartilaginous extracellular matrix is available. We recently analyzed the coordinated expression of proteins involved in the biosynthesis of proteoglycans and collagens, the two major components of cartilage matrix, to understand matrix formation and to provide potential tools to improve the quality of tissue-engineered cartilage.
authors: Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum, Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany. cgoetting@hdz-nrw.de
authors: Christian
authors: C
authors: Götting
authors: Christian
authors: C
authors: Prante
authors: Joachim
authors: J
authors: Kuhn
authors: Knut
authors: K
authors: Kleesiek
mesh_terms: D002356:Cartilage / Q000254:growth & development; D002454:Cell Differentiation / Q000502:physiology; D020219:Chondrogenesis / Q000502:physiology*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D010430:Pentosyltransferases / Q000502:physiology; D011509:Proteoglycans / Q000096:biosynthesis*; D023822:Tissue Engineering; D000097608:UDP Xylose-Protein Xylosyltransferase
chemical_list: D010430:Pentosyltransferases; D011509:Proteoglycans; D000097608:UDP Xylose-Protein Xylosyltransferase