[Development of animal model for understanding of pathogenesis of subacute sclerosing panencephalitis using non-human primates].
Many animal models using experimental small animals for subacute sclerosing panencephalitis (SSPE) had been reported. But these models were not enough for understanding of pathogenesis of SSPE. After pathogenic measles virus was isolated with highly susceptible B95a cells, mimic infection of measles in human beings became easily produced in non-human primates. In this article, our attempt to develop SSPE model using cynomolgus monkeys will be introduced.
Ami
Yasushi
Y
Division of Experimental Animal Research, National Institute of Infectious Disease.
D000818:Animals; D002490:Central Nervous System / Q000821:virology; D004195:Disease Models, Animal; D006801:Humans; D008252:Macaca fascicularis; D008459:Measles virus / Q000302:isolation & purification / Q000472:pathogenicity; D013190:SSPE Virus / Q000302:isolation & purification / Q000472:pathogenicity; D013344:Subacute Sclerosing Panencephalitis / Q000209:etiology