title: Skeletal diversity through radical cyclization of tetrahydropyridine scaffolds.
abstract: Suitably functionalized tetrahydropyridines (methyl pipecolates) have been used as conformationally biased templates for radical cyclizations to access benzoisoquinuclidines and linearly fused indenopiperidines. Variation of skeletal types is determined by location of a radical-initiating element.
authors: Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
authors: Sivaraman
authors: S
authors: Dandapani
authors: Mihai
authors: M
authors: Duduta
authors: James S
authors: JS
authors: Panek
authors: John A
authors: JA
authors: Porco
mesh_terms: D000478:Alkylation; D002244:Carbon / Q000737:chemistry; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry; D006827:Hydantoins / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005609:Free Radicals; D006827:Hydantoins; D011725:Pyridines; D002244:Carbon; D006859:Hydrogen