Mechanisms and role of HLA and non-HLA alloantibodies.
The role of alloantibodies against HLA and non-HLA targets is becoming increasingly recognized as critical in the pathogenesis of acute and chronic renal allograft outcomes. This review discusses the antigenic targets, the mechanisms of T and B cell activation that result in the production of antibody, the complement cascade, methods of antibody detection, and the evidence that alloantibody-mediated mechanisms are active in acute and chronic rejection.
Tinckam
Kathryn J
KJ
Transplantation Research Center, Brigham and Women's Hospital, Boston, MA 02115, USA. ktinckam@rics.bwh.harvard.edu
Chandraker
Anil
A
D006084:Graft Rejection / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000502:physiology*; D016030:Kidney Transplantation / Q000276:immunology*
D006680:HLA Antigens; D007518:Isoantibodies