Cephalosporolides H and I, Two Novel Lactones from a Marine-Derived Fungus, Penicillium sp.
Two novel lactones, Cephalosporolides H (1) and 1 (2), were isolated from the lyophilized culture broth of the marine-derived fungus, Penicillium sp. The structures were elucidated on the basis of extensive 1D- and 2D-NMR, as well as HRESI-MS spectroscopic analyses. The relative stereochemistries of the compounds were assessed by comparison of the NOESY analysis and spectral data with those in the literature.
Li
Xiang
X
Pharmaceutical College of Jilin Agricultural University, Changchun Jilin, 130118, P R. China. lixi@agr.gc.ca
Yao
Yanhua
Y
Zheng
Yinan
Y
Sattler
Isabel
I
Lin
Wenhan
W
D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) / Q000037:antagonists & inhibitors; D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry* / Q000302:isolation & purification; D043982:Rhizophoraceae / Q000382:microbiology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D004791:Enzyme Inhibitors; D007783:Lactones; D013141:Spiro Compounds; C523374:cephalosporolide H; C523375:cephalosporolide I; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); D014969:Xanthine Oxidase; D015107:4-Butyrolactone