Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis.
OBJECTIVE
To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis and the pathogenesis of silicosis.


METHODS
Thirty healthy volunteers, 30 silica-exposed workers, and 30 workers with suspected silicosis and phase I silicosis were included. Serum CC16 and SP-D concentrations were determined using enzyme-linked immunosorbent assay.


RESULTS
Serum CC16 concentrations decreased in silica-exposed workers when compared with in controls, but serum SP-D levels increased, and this trend was obvious in phase 0 and I groups. Discriminant analysis showed that the accuracies of classifying group membership into control, phase 0, phase 0, and phase I were 86.7%, 46.7%, 66.7%, and 70%, respectively, and the total classification accuracy rate was 67.5%.


CONCLUSIONS
Serum CC16 and SP-D may be useful biomarkers for early diagnosis, and serum SP-D concentration may associate with the pathogenesis of silicosis.
Wang
Shi-Xin
SX
Proteomics Laboratory, Medical College of Chinese People's Armed Police Force, Tianjin, China.
Liu
Ping
P
Wei
Mao-Ti
MT
Chen
Lei
L
Guo
Yang
Y
Wang
Ran-Yang
RY
Tu
Zhi-Guang
ZG
Liang
Xian-Cai
XC
D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D042241:Early Diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008906:Mining; D016273:Occupational Exposure / Q000009:adverse effects*; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood* / Q000502:physiology; D012822:Silicon Dioxide / Q000009:adverse effects*; D012829:Silicosis / Q000175:diagnosis* / Q000503:physiopathology; D014598:Uteroglobin / Q000097:blood* / Q000502:physiology
D000395:Air Pollutants, Occupational; D015415:Biomarkers; D037663:Pulmonary Surfactant-Associated Protein D; C556389:SCGB1A1 protein, human; D012822:Silicon Dioxide; D014598:Uteroglobin