title: TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.
abstract: TEM-158 was found to include the substitutions previously observed for TEM-12 and TEM-35. This enzyme presented hydrolytic activity against ceftazidime and a high level of resistance against clavulanate, which can alter its detection. Its discovery highlights the need for accurate detection methods.
authors: CHU Clermont-Ferrand, Centre de Biologie, Laboratoire de bactériologiecinique, Faculté de Médecine, 28 place H. Dunant, 63001 Clermont-Ferrand, France. frobin@chu-clermontferrand.fr
authors: Frédéric
authors: F
authors: Robin
authors: Julien
authors: J
authors: Delmas
authors: Amélie
authors: A
authors: Brebion
authors: Damien
authors: D
authors: Dubois
authors: Jean-Michel
authors: JM
authors: Constantin
authors: Richard
authors: R
authors: Bonnet
mesh_terms: D002384:Catalysis; D002442:Ceftazidime / Q000494:pharmacology; D019818:Clavulanic Acid / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*; D047090:beta-Lactams / Q000378:metabolism / Q000494:pharmacology
chemical_list: D029968:Escherichia coli Proteins; D007527:Isoenzymes; D047090:beta-Lactams; D019818:Clavulanic Acid; D002442:Ceftazidime; D001618:beta-Lactamases; C525735:beta-lactamase TEM-158, E coli
references: Antimicrob Agents Chemother. 2000 Jun;44(6):1499-505
references: 10817699
references: Antimicrob Agents Chemother. 2000 Nov;44(11):3232-4
references: 11036062
references: Antimicrob Agents Chemother. 2001 Dec;45(12):3591-4
references: 11709345
references: Antimicrob Agents Chemother. 1994 Oct;38(10):2452-3
references: 7840586
references: Antimicrob Agents Chemother. 2007 Apr;51(4):1304-9
references: 17220412
references: J Antimicrob Chemother. 1999 Apr;43(4):447-58
references: 10350372
references: Antimicrob Agents Chemother. 2004 Dec;48(12):4528-31
references: 15561821
references: Antimicrob Agents Chemother. 2005 Nov;49(11):4443-7
references: 16251281
references: Antimicrob Agents Chemother. 2006 Jul;50(7):2403-8
references: 16801418
references: Antimicrob Agents Chemother. 1997 Jun;41(6):1322-5
references: 9174192