title: Disturbances in melatonin and core body temperature circadian rhythms after minimal invasive surgery.
abstract: BACKGROUND
  Sleep disturbances, fatigue and reduced general well-being frequently occur after minimal invasive surgery. The circadian rhythms of melatonin and core body temperature are central to the regulation of normal sleep. The aim of this study was to assess changes in these circadian rhythms after laparoscopic cholecystectomy.
  
  
  METHODS
  Twelve women were studied before and after laparoscopic cholecystectomy. The major urinary melatonin metabolite, 6-sulphatoxymelatonin (aMT6s), and the core body temperature were measured for 1 day before and 1 day after surgery. The basal and maximum secretion of aMT6s were determined, as well as the timing and amplitude of aMT6s and the temperature rhythm. The patients' rest-activity and calculated sleep parameters were assessed by actigraphy.
  
  
  RESULTS
  A significant delay in the timing of aMT6s rhythm was observed after surgery [median (range) peak time of aMT6s: after surgery, 05:49 h (02:57-08:23 h); before surgery, 04:32 h (02:18-06:49 h); P< or = 0.05]. The amplitude of the aMT6s rhythm was also significantly decreased after surgery [after surgery, 7.1 ng aMT6s/mg creatinine (1-15.9 ng); before surgery, 13.2 ng aMT6s/mg creatinine (2.9-22.7 ng); P< or = 0.005]. There was almost a 12-h phase delay of the core body temperature rhythm after surgery [peak time: before surgery, 17:39 h (15:17-22:06 h); after surgery, 05:14 h (03:24-21:43 h); P< or = 0.01].
  
  
  CONCLUSIONS
  Following laparoscopic cholecystectomy, there was a delay in the timing of the aMT6s rhythm and a decreased evening decline in the temperature rhythm.
authors: Department of Surgical Gastroenterology D, University of Copenhagen, Gentofte Hospital, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark. ismgog01@gentoftehosp.kbhamt.dk
authors: I
authors: I
authors: Gögenur
authors: B
authors: B
authors: Middleton
authors: V B
authors: VB
authors: Kristiansen
authors: D J
authors: DJ
authors: Skene
authors: J
authors: J
authors: Rosenberg
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D001833:Body Temperature Regulation / Q000502:physiology*; D017081:Cholecystectomy, Laparoscopic; D002940:Circadian Rhythm / Q000502:physiology*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D012890:Sleep / Q000502:physiology; D013997:Time Factors
chemical_list: D015415:Biomarkers; C054513:6-sulfatoxymelatonin; D003404:Creatinine; D008550:Melatonin