Antifungal effect of acrylic resin containing apatite-coated TiO2 photocatalyst.
The purpose of this study was to develop an acrylic resin with antifungal properties by leveraging the photocatalytic activity of apatite-coated titanium dioxide (Ap-TiO2). Candida albicans was used for antifungal activity assay of the specimen plates under ultraviolet A (UVA) with a black light source. Statistically significant decreases in cell viability in acrylic resins containing 5 wt% and 10 wt% Ap-TiO2 were observed after irradiation for two, four, and six hours (P<0.01), when compared to the control. As for the flexural strength and modulus values of acrylic resins mixed with Ap-TiO2 and TiO2 particles, they varied before and after irradiation. Among the tested specimens, a 5 wt% content of Ap-TiO2 in acrylic resin exceeded the requirements of ISO 1567. It was thus suggested that acrylic resin containing 5 wt% Ap-TiO2 could exert antifungal effects on C. albicans, while at the same time maintain adequate mechanical properties for clinical use.
Shibata
Takeshi
T
Division of Prosthetics, Department of Oral and Maxillofacial Rehabilitation, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka-shi, Kanagawa 238-8580, Japan. shibata@kdcnet.ac.jp
Hamada
Nobushiro
N
Kimoto
Katsuhiko
K
Sawada
Tomofumi
T
Sawada
Tomoji
T
Kumada
Hidefumi
H
Umemoto
Toshio
T
Toyoda
Minoru
M
D000180:Acrylic Resins / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D003764:Dental Materials / Q000737:chemistry / Q000494:pharmacology*; D014025:Titanium / Q000494:pharmacology / Q000528:radiation effects
D000180:Acrylic Resins; D000935:Antifungal Agents; D003764:Dental Materials; C009495:titanium dioxide; D014025:Titanium