title: Isocoumarin Derivatives from the Sea Squirt-derived Fungus Penicillium stoloniferum QY2-10 and the Halotolerant Fungus Penicillium notatum B-52.
abstract: Two isocoumarin derivatives, stoloniferol A (1) and B (2), a known 5alpha, 8alpha-epidioxy-23-methyl-(22E, 24R)-ergosta-6, 22-dien-3beta-ol (3), and a known dihydrocitrinone (4) were isolated from the ethyl acetate extract of the sea squirt-derived fungus, Penicillium stoloniferum QY2-10, and a halophilic fungus, Penicillium notatum B-52, respectively. Their structures were elucidated by spectroscopic methods and optical rotation. The stereochemistry of 2 was determined on the basis of different NOE experiments and chemical transformation. Compound 3 showed cytotoxicity against P388 cells, with an IC50 value of 4.07 microM.
authors: Key laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, P R China.
authors: Zhi-Hong
authors: ZH
authors: Xin
authors: Li
authors: L
authors: Tian
authors: Tian-Jiao
authors: TJ
authors: Zhu
authors: Wen-Liang
authors: WL
authors: Wang
authors: Lin
authors: L
authors: Du
authors: Yu-Chun
authors: YC
authors: Fang
authors: Qian-Qun
authors: QQ
authors: Gu
authors: Wei-Ming
authors: WM
authors: Zhu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D020128:Inhibitory Concentration 50; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry / Q000302:isolation & purification; D010408:Penicillium chrysogenum / Q000737:chemistry* / Q000302:isolation & purification; D012623:Seawater; D014561:Urochordata / Q000382:microbiology*
chemical_list: D000970:Antineoplastic Agents; D049934:Isocoumarins