Review of osmotic pressure driven release of proteins from monolithic devices.
Protein therapeutics are a rapidly growing drug class, with sales in 2004 in the area of $US 34 billion. They are presently administered primarily by injection, although there is increasing recognition that many proteins would benefit from long-term, localized delivery. Such delivery represents a significant challenge due principally to protein stability concerns. Polymeric delivery systems which rely on osmotic pressure driven drug release may prove to be an effective formulation approach. This paper reviews the evolution of osmotic pressure drug release from polymers, with an emphasis on their potential for protein delivery. It is concluded that osmotic pressure driven release is promising for protein delivery, but there is still a need for in vivo demonstration of protein stability and delivery efficacy.
Amsden
Brian
B
Department of Chemical Engineering, Queen's University, Kingston, ON, Canada. brian.amsden@chee.queensu.ca <amsden@chee.queensu.ca>
D000818:Animals; D016503:Drug Delivery Systems; D008956:Models, Chemical; D009997:Osmotic Pressure; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry*; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry*
D011108:Polymers; D011506:Proteins