Detection of trace Al in model biological tissue with laser-induced breakdown spectroscopy.
Laser-induced breakdown spectroscopy (LIBS), which is an excellent tool for trace elemental analysis, was studied as a method of detecting sub-part-per-10(6) (ppm) concentrations of aluminum in surrogates of human tissue. Tissue was modeled using a 2% agarose gelatin doped with an Al(2)O(3) nanoparticle suspension. A calibration curve created with standard reference samples of known Al concentrations was used to determine the limit of detection, which was less than 1 ppm. Rates of false negative and false positive detection results for a much more realistic sampling methodology were also studied, suggesting that LIBS could be a candidate for the real-time in vivo detection of metal contamination in human soft tissue.
Adamson
Marian D
MD
Department of Physics and Astronomy, Wayne State University, Detroit, Michigan 48201, USA.
Rehse
Steven J
SJ
D000535:Aluminum / Q000032:analysis* / Q000737:chemistry; D000537:Aluminum Oxide / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D002138:Calibration; D004867:Equipment Design; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D007834:Lasers; D008954:Models, Biological; D055095:Optics and Photonics; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012685:Sepharose / Q000737:chemistry; D013997:Time Factors; D014131:Trace Elements / Q000032:analysis*
D014131:Trace Elements; D012685:Sepharose; D000535:Aluminum; D000537:Aluminum Oxide; D002118:Calcium