The making of a bone in blood vessels: from the soft shell to the hard bone.
Vascular calcification, particularly of the medial layer of arteries, is one of the key determinants of survival in patients with chronic kidney disease. This abnormality is not merely a simple process of precipitation of calcium and phosphate but also includes several mechanisms similar to those of bone formation within the vessel wall.
Fukagawa
M
M
Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan. fukagawa@med.kobe-u.ac.jp
Kazama
J J
JJ
D001808:Blood Vessels / Q000378:metabolism / Q000473:pathology; D002114:Calcinosis; D006244:Hardness; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000473:pathology; D010012:Osteogenesis; D014652:Vascular Diseases / Q000209:etiology* / Q000473:pathology