title: Polymorphisms of the DNA gene XPD and risk of bladder cancer in a Southeastern Chinese population.
abstract: The incidence rate for bladder cancer has been increasing in many countries, and bladder cancer is the most common urinary cancer in China. We explored the association of single-nucleotide polymorphisms in DNA repair genes with bladder cancer. The hypothesis is that the xeroderma pigmentosum complementary group D (XPD) 156-22541C-->A and 751-35931A-->C polymorphisms are associated with the risk of bladder cancer. In a population-based case-control study, 215 patients with newly diagnosed bladder transitional cell carcinoma and 245 cancer-free controls/healthy subjects (frequency-matched by the age and sex) were genotyped. These two polymorphisms were studied using the polymerase chain reaction restriction fragment length polymorphism method. We found that the A allele of XPD Arg156Arg (C22541A) and the C allele of XPD Lys751Gln (A35931C) is associated with increased risk of bladder cancer (adjusted odds ratio = 1.54 and 95% confidence interval = 1.19-2.01, 1.65, and 1.12-2.73, respectively). Smoking is also a risk factor in the etiology of bladder cancer, but alcohol intake is a protective factor during the development of bladder cancer. These two XPD polymorphisms may play an important role in the etiology of bladder cancer in the southeastern Chinese population.
authors: Department of Urological Surgery, Wuxi No.1 People's Hospital Affiliated to Nanjing Medical University, People Road 111, Wuxi, PR China.
authors: Jianfeng
authors: J
authors: Shao
authors: Min
authors: M
authors: Gu
authors: Zhuoqun
authors: Z
authors: Xu
authors: Qiang
authors: Q
authors: Hu
authors: Lixin
authors: L
authors: Qian
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004260:DNA Repair; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D012907:Smoking; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000235:genetics*; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human