title: Primary immune surveillance: some like it hot.
abstract: The thermal element of fever has been found to be beneficial in models of infectious disease. The contributions of fever-range temperatures to the efficacy of the adaptive immune response have only begun to be delineated. There is accumulating evidence that fever-range thermal stress bolsters primary immune surveillance of lymph nodes and Peyer patches by augmenting lymphocyte extravasation across specialized vessels termed high endothelial venules. Molecular mechanisms have recently come to light by which the thermal component of fever alone may promote lymphocyte trafficking, and thereby the probability of mounting a defense against microbial infection. Acquired knowledge of the molecular changes associated with thermal stress may allow for the development of novel therapies for a variety of disease processes.
authors: Department of Immunology, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, USA.
authors: Joseph J
authors: JJ
authors: Skitzki
authors: Qing
authors: Q
authors: Chen
authors: W C
authors: WC
authors: Wang
authors: Sharon S
authors: SS
authors: Evans
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004729:Endothelium, Lymphatic / Q000276:immunology; D005334:Fever / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D006979:Hyperthermia, Induced; D007113:Immunity, Innate / Q000187:drug effects; D015850:Interleukin-6 / Q000378:metabolism; D036904:Leukocyte Rolling / Q000187:drug effects; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D010581:Peyer's Patches / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology
chemical_list: D018712:Analgesics, Non-Narcotic; D015850:Interleukin-6
references: Infect Dis Clin North Am. 1996 Mar;10(1):1-20
references: 8698984
references: J Cell Physiol. 1998 Oct;177(1):137-47
references: 9731754
references: Mol Immunol. 2005 May;42(7):799-809
references: 15829268
references: Drugs Today (Barc). 2006 Sep;42(9):559-76
references: 17028666
references: Am J Respir Crit Care Med. 1995 Jan;151(1):10-4
references: 7812538
references: Methods. 2004 Jan;32(1):54-62
references: 14624878
references: J Immunol. 2004 Dec 1;173(11):6753-9
references: 15557168
references: J Immunol. 2003 Sep 15;171(6):3202-9
references: 12960349
references: Int J Cancer. 2007 Jun 1;120(11):2418-25
references: 17294445
references: J Immunol. 1998 Jan 15;160(2):961-9
references: 9551935
references: Eur J Biochem. 2001 Jan;268(1):160-7
references: 11121117
references: J Appl Physiol (1985). 1987 Sep;63(3):1246-52
references: 3654470
references: Arch Intern Med. 2000 Feb 28;160(4):449-56
references: 10695685
references: Nature. 1977 May 5;267(5606):43-5
references: 859637
references: Cancer Immunol Immunother. 2003 Nov;52(11):670-9
references: 12920482
references: Clin Infect Dis. 2000 Oct;31 Suppl 5:S185-9
references: 11113022
references: J Leukoc Biol. 2006 Aug;80(2):227-36
references: 16707558
references: Ann Intern Med. 1994 Jun 15;120(12):1037-40
references: 7832829
references: Int J Hyperthermia. 2005 Dec;21(8):761-7
references: 16338859
references: J Clin Invest. 2005 Jun;115(6):1616-26
references: 15931392
references: Science. 1996 Apr 5;272(5258):60-6
references: 8600538
references: Cancer Immunol Immunother. 2006 Mar;55(3):299-311
references: 16044255
references: J Cell Biol. 2004 Oct 25;167(2):377-88
references: 15504916
references: Eur J Immunol. 2004 Oct;34(10):2635-41
references: 15368278
references: Int J Hyperthermia. 2002 May-Jun;18(3):253-66
references: 12028640
references: Br J Cancer. 2006 Jan 30;94(2):275-80
references: 16421594
references: Nat Rev Immunol. 2004 Mar;4(3):211-22
references: 15039758
references: Nat Rev Immunol. 2003 Nov;3(11):867-78
references: 14668803
references: J Immunol. 2001 Sep 1;167(5):2666-70
references: 11509609
references: J Exp Med. 1976 Sep 1;144(3):828-33
references: 956727
references: Science. 2006 Sep 29;313(5795):1960-4
references: 17008531
references: Science. 1976 Jul 16;193(4249):237-9
references: 935867
references: Cancer Res. 2001 Sep 15;61(18):6860-7
references: 11559562
references: Int J Hyperthermia. 2000 Jan-Feb;16(1):45-59
references: 10669316
references: Rev Infect Dis. 1991 May-Jun;13(3):462-72
references: 1866550
references: J Dermatol Sci. 1997 Aug;15(2):75-81
references: 9279687
references: Physiol Rev. 1991 Jan;71(1):93-127
references: 1986393
references: FASEB J. 2001 Jan;15(1):43-58
references: 11149892
references: Int J Radiat Oncol Biol Phys. 2001 Apr 1;49(5):1259-66
references: 11286832
references: Cancer Immunol Immunother. 2006 Mar;55(3):292-8
references: 15864585
references: Annu Rev Immunol. 2004;22:129-56
references: 15032576
references: Microbes Infect. 2000 Dec;2(15):1891-904
references: 11165933
references: J Immunol. 1999 Mar 15;162(6):3615-24
references: 10092822
references: Blood. 2001 May 1;97(9):2727-33
references: 11313264
references: Cancer Res. 2004 Mar 15;64(6):2183-91
references: 15026361
references: J Immunol. 2005 Sep 15;175(6):3463-8
references: 16148087
references: Immunity. 2004 Jan;20(1):59-70
references: 14738765
references: Cancer Immunol Immunother. 1999 Oct;48(7):386-95
references: 10501852
references: Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):258-63
references: 9419363
references: Nat Immunol. 2006 Dec;7(12):1299-308
references: 17086187
references: J Exp Med. 2000 Jan 3;191(1):61-76
references: 10620605