title: Oral leiomyosarcomas: report of two cases with immunohistochemical profile.
abstract: Leiomyosarcoma of the oral cavity is a very rare tumor associated with aggressive clinical behavior and low survival. In this paper, we report 2 cases of leiomyosarcoma, affecting the gingival mucosa of a 54-year-old female and the maxillary bone of a 63-year-old male. Histologically, the tumors were composed of variably oriented fascicles of spindle-shaped cells with cigar-shaped nuclei and eosinophilic cytoplasm. The lesions were treated by surgical resection. Immunoreactivity to anti-vimentin, anti-smooth muscle actin, anti-desmin, anti-laminin, and anti-muscle-specific actin antibodies were found; conversely, the tumor cells were negative for anti-S100 and AE1/AE3 proteins. This report emphasizes the role of immunohistochemical study for correct diagnosis of leiomyosarcoma.
authors: Department of Stomatology (Oral Pathology), Dental School, University of São Paulo, São Paulo, Brazil. carodini@usp.br
authors: Camila Oliveira
authors: CO
authors: Rodini
authors: Flávia Sirotheau Corrêa
authors: FS
authors: Pontes
authors: Hélder Antônio Rebelo
authors: HA
authors: Pontes
authors: Paulo Sérgio da Silva
authors: PS
authors: Santos
authors: Marina Gallottini
authors: MG
authors: Magalhães
authors: Décio Santos
authors: DS
authors: Pinto
mesh_terms: D000199:Actins / Q000032:analysis; D005260:Female; D005887:Gingival Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis; D007890:Leiomyosarcoma / Q000737:chemistry* / Q000473:pathology; D008297:Male; D008441:Maxillary Neoplasms / Q000737:chemistry* / Q000473:pathology; D008875:Middle Aged
chemical_list: D000199:Actins; D007381:Intermediate Filament Proteins