title: Impact of the smallest surgical margin on local control in soft tissue sarcoma.
abstract: BACKGROUND
  The aim was to review a single-institution experience of a prospective treatment protocol for soft tissue sarcoma of the extremity and trunk wall, with particular focus on the smallest surgical margin leading to local control.
  
  
  METHODS
  The study included 270 patients who had surgery for soft tissue sarcoma at Helsinki University Central Hospital between 1987 and 1997. Resection margins were measured prospectively from tumour specimens. Radiotherapy was administered if the smallest margin measured less than 2.5 cm, irrespective of tumour grade.
  
  
  RESULTS
  With a median follow-up of 6.6 years, the 5-year local control rate was 76.4 per cent. On multivariable analysis, the smallest surgical margin around the sarcoma (after radiotherapy) was prognostic for local control. A margin of at least 2.5 cm was associated with a local recurrence-free rate of 89.2 per cent at 5 years. Tumour size, depth or grade and patient's age had no independent prognostic effect on local control.
  
  
  CONCLUSIONS
  Surgical margin had independent prognostic value for local control. A surgical margin of 2-3 cm provided reasonable local control of soft tissue sarcoma, even without radiotherapy. Radiotherapy is recommended for smaller margins, irrespective of tumour grade.
authors: Department of Pathology, HUSLAB and University of Helsinki, Helsinki, Finland. mika.sampo@helsinki.fi
authors: M
authors: M
authors: Sampo
authors: M
authors: M
authors: Tarkkanen
authors: R
authors: R
authors: Huuhtanen
authors: E
authors: E
authors: Tukiainen
authors: T
authors: T
authors: Böhling
authors: C
authors: C
authors: Blomqvist
mesh_terms: D034861:Abdominal Wall; D000328:Adult; D000368:Aged; D000671:Amputation, Surgical / Q000706:statistics & numerical data; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002985:Clinical Protocols; D005121:Extremities; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D009372:Neoplasms, Connective Tissue / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D016896:Treatment Outcome