[Advance of study on apoptosis inducer of several types of natural drug].
Along with the deep-going researches on mechanism of apoptosis, the apoptosis inducers as anticancer drugs have been the hot points of researches for new drugs. In this paper are reviewed a number of related articles on the progress in cell apoptosis inducers including the derivative anthraquinone, saponin, flavonids and terpines. The mechanisms are analyzed and discussed. The researches into the molecular mechanisms of inducer can provide the theoretical basis for discovering new compound, and can find out the apoptosis inducers with high efficiency and low toxicity. There is hope of developing apoptosis inducers into safe and effectual anticancer drugs.
Song
Yi
Y
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China. songyi8686@yahoo.com.cn
Zeng
Ying
Y
Su
Lan
L
Zhang
Zhiyong
Z
D045784:Abietanes; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D004642:Emodin / Q000494:pharmacology*; D047309:Flavones / Q000494:pharmacology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010616:Phenanthrenes / Q000494:pharmacology; D012503:Saponins / Q000494:pharmacology*
D045784:Abietanes; D000970:Antineoplastic Agents; D047309:Flavones; D010616:Phenanthrenes; D012503:Saponins; C021751:tanshinone; D004642:Emodin