The antifungal polyketide ambruticin targets the HOG pathway.
The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of action has not yet been elucidated. Here we present evidence that ambruticin exerts its effect by targeting HOG, the osmotic stress control pathway, through Hik1, a group III histidine kinase.
Vetcher
Leandro
L
Kosan Biosciences Inc, Hayward, CA 94545, USA.
Menzella
Hugo G
HG
Kudo
Toshiaki
T
Motoyama
Takayuki
T
Katz
Leonard
L
D000935:Antifungal Agents / Q000494:pharmacology*; D015153:Blotting, Western; D005658:Fungi / Q000187:drug effects*; D005990:Glycerol / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics*; D009994:Osmolar Concentration; D010766:Phosphorylation; D011714:Pyrans / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D015398:Signal Transduction / Q000187:drug effects*; D015003:Yeasts / Q000187:drug effects
D000935:Antifungal Agents; D011714:Pyrans; D029701:Saccharomyces cerevisiae Proteins; C088589:HOG1 protein, S cerevisiae; D020928:Mitogen-Activated Protein Kinases; D005990:Glycerol; C014964:ambruticin
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