Positive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia.
The aim of our study was to evaluate the relationship of adiponectin to soluble forms of vascular cell adhesion molecule-1 (sVCAM-1) and intercellular cell adhesion molecule-1 (sICAM-1) in patients with cardiovascular disease or dyslipidemia. Two hundred and sixty-four patients (134 men/130 women, mean age 43.8+/-14.8/46.0+/-14.9 years) of Lipid Center, University Hospital Olomouc, off hypolipidemic therapy for at least 6 weeks, participated in the study. In multiple regression analysis, adiponectin was independently positively associated with serum HDL-cholesterol (p<0.0001) and sVCAM-1 (p<0.0001), female gender (p<0.0001) and negatively with hs-CRP (p=0.014). Serum concentration of adiponectin and sICAM-1 did not correlate but sICAM-1 was independently, positively associated with sVCAM-1 (p<0.0001) and negatively with markers of insulin resistance and inflammation, namely atherogenic index log[triglycerides/HDL-cholesterol] (p<0.0001), hs-CRP (p<0.001) and HOMA (p<0.05). Positive association of adiponectin with HDL-C and negative association with hs-CRP indicate anti-atherogenic properties of adiponectin. The finding of the positive association of adiponectin with sVCAM-1 in patients at risk is unexpected. We hypothesize that adiponectin may be involved (directly or indirectly) in shedding of ectodomains of VCAM-1 from endothelial surface and in this way down-regulates their effects. This process may be protective in the initial stages of atherosclerosis.
Vaverkova
Helena
H
3rd Department of Internal Medicine, University Hospital Olomouc, 775 20 Olomouc, Czech Republic. helena.vaverkova@fnol.cz
Karasek
David
D
Novotny
Dalibor
D
Jackuliakova
Dagmar
D
Halenka
Milan
M
Lukes
Jiri
J
Frohlich
Jiri
J
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood*; D004852:Epoxy Compounds; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D015228:Hypertriglyceridemia / Q000097:blood*; D007249:Inflammation / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood; D020521:Stroke / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D004852:Epoxy Compounds; D019010:Vascular Cell Adhesion Molecule-1; C516444:triglycidylamine; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein