[The deleterious effect of certain surface active agents on the ocular surface].
Most ocular solutions enter the eye through the corneal epithelial barrier. In order to pass through this barrier, these hydrosoluble drugs require to be associated with a detergent agent to increase topical efficiency. Although these agents have a preservative action, it was recently demonstrated that, after short or long term use, toxic side effects on the ocular surface will occur.
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Service d'Ophtalmologie, Hôpital Erasme, Université Libre de Bruxelles, Bruxelles. oliravet@hotmail.com
D000287:Administration, Topical; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects; D002354:Carteolol / Q000008:administration & dosage / Q000009:adverse effects; D019573:Epithelium, Corneal / Q000378:metabolism; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D012995:Solubility; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics
D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical; D013501:Surface-Active Agents; D002354:Carteolol