title: Assessment of the vascularity of uterine leiomyomas using double-echo dynamic perfusion-weighted MRI with the first-pass pharmacokinetic model: correlation with histopathology.
abstract: OBJECTIVE
  To retrospectively evaluate the feasibility of perfusion-weighted MRI (PWI) in uterine leiomyomas.
  
  
  METHODS
  : Eighteen uterine leiomyomas in 15 patients were evaluated. PWI was performed using a double-echo T2*-weighted spoiled gradient-recalled acquisition sequence, and the first-pass pharmacokinetic model was applied to calculate relative blood volume (rBV). Histopathologic analysis was performed to measure vascular area (VA).
  
  
  RESULTS
  PWI was successful in 13 of 15 patients. On quantitative analysis, mean (+/-SD) rBV calculated from PWI was 0.17 +/- 0.13 (range, 0.06-0.55), whereas mean VA was 3.3% +/- 1.6% (range, 1.7-8.5%). A significant correlation was identified between rBV and VA (r = 0.87, P < 0.001).
  
  
  CONCLUSIONS
  The rBV determined at PWI correlates with histologic vascular area in uterine leiomyomas.
authors: Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. nkosaka@fmsrsa.fukui-med.ac.jp
authors: Nobuyuki
authors: N
authors: Kosaka
authors: Hidemasa
authors: H
authors: Uematsu
authors: Hirohiko
authors: H
authors: Kimura
authors: Yoshiyuki
authors: Y
authors: Ishimori
authors: Tetsuji
authors: T
authors: Kurokawa
authors: Tsuyoshi
authors: T
authors: Matsuda
authors: Harumi
authors: H
authors: Itoh
mesh_terms: D000328:Adult; D003198:Computer Simulation; D003287:Contrast Media / Q000493:pharmacokinetics; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D019786:Gadolinium DTPA / Q000493:pharmacokinetics*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007889:Leiomyoma / Q000098:blood supply / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D010477:Perfusion; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014594:Uterine Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA