title: Daily mood as a mediator or moderator of the pain-sleep relationship in children with sickle cell disease.
abstract: OBJECTIVE
  To investigate mood as a mediator or moderator of the pain-sleep relationship in children with sickle cell disease (SCD).
  
  
  METHODS
  Children with SCD (n = 20; aged 8-12 years) completed daily diaries assessing mood, sleep, and pain for up to 2 months. Data was analyzed using multilevel modeling. Results Results indicate that negative mood partially mediates the relationship between high daily pain and poor sleep that night as well the relationship between poor sleep and high daily pain the following day. The impact of poor sleep on high pain the following day was weakened at increasing levels of positive mood.
  
  
  CONCLUSIONS
  Research is needed to fully explore the ways positive and negative mood may relate to pain and sleep characteristics. This information may be beneficial for developing more effective pain management and sleep interventions.
authors: Department of Psychology, University of North Carolina at Chapel Hill, Greenville, NC 27858, USA. valriec@ecu.edu
authors: Cecelia R
authors: CR
authors: Valrie
authors: Karen M
authors: KM
authors: Gil
authors: Rupa
authors: R
authors: Redding-Lallinger
authors: Charles
authors: C
authors: Daeschner
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000755:Anemia, Sickle Cell / Q000453:epidemiology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D010146:Pain / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D010147:Pain Measurement; D015995:Prevalence; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology*
chemical_list: D000700:Analgesics