Antioxidant status of South Indian patients undergoing coronary artery bypass graft surgery: a role of intra operative magnesium supplementation.
The aim of the study is to evaluate the effect of magnesium on the level and progression of oxidative stress in the erythrocytes and erythrocyte membrane, during heart surgery involving cardiopulmonary bypass. A clinical trial (n=52) was conducted and we took five blood samples at different times during the cardiac surgery. The level of lipid per-oxidation and activity of antioxidant enzymes were analyzed. The results revealed an increase in oxidative stress after CPB in erythrocytes and erythrocyte membrane. However, the extensive treatment of the patients with magnesium influences the cellular response to ischemia and thus induces cardio-protection against oxidative stress.
Kurian
Gino A
GA
Phil
M
M
Paddikkala
Jose
J
D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007194:India; D007430:Intraoperative Care; D008055:Lipids / Q000097:blood; D008274:Magnesium / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D015427:Reperfusion Injury / Q000378:metabolism
D000975:Antioxidants; D008055:Lipids; D008274:Magnesium