Oxidative damage in liver after perinatal intoxication with lead and/or cadmium.
Lead acetate (300 mg Pb/L) and/or cadmium acetate (10mg Cd/L) in blood and liver were administrated as drinking water to pregnant Wistar rats from day 1 of pregnancy to parturition (day 0) or until weaning (day 21), to investigate the toxic effects in blood and in the liver. Both metals produced mycrocitic anaemia in the pups as well as oxidative damage in the liver, as suggested by the significant increase in TBARS production and the high catalase activity. Moreover, intense alkaline and acid phosphatase activity, used as biomarkers of liver adaptation to damaging factors, was observed. In addition, the toxikinetics are different for Pb and Cd: while Cd is a hepatotoxic from day 0, Pb is not until day 21. Finally, simultaneous perinatal administration of both metals seems to protect, at least, in the liver TBARS production against the toxicity produced by Cd or Pb separately.
Massó
Elvira Luján
EL
Department of Animal Physiology II, Biology College, Complutense University of Madrid, Madrid, Spain. elviraceife@telefonica.net
Corredor
Laura
L
Antonio
Maria Teresa
MT
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D002104:Cadmium / Q000008:administration & dosage; D002105:Cadmium Poisoning / Q000378:metabolism / Q000473:pathology*; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D004338:Drug Combinations; D005260:Female; D007854:Lead / Q000008:administration & dosage; D007855:Lead Poisoning / Q000378:metabolism / Q000473:pathology*; D008107:Liver Diseases / Q000378:metabolism; D009929:Organ Size; D018384:Oxidative Stress; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D004338:Drug Combinations; D017392:Thiobarbituric Acid Reactive Substances; D002104:Cadmium; D007854:Lead; D002374:Catalase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase