Lipoprotein-associated phospholipase A(2) : review of its role as a marker and a potential participant in coronary endothelial dysfunction.
The role of inflammation in atherosclerosis continues to emerge. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), a novel plasma biomarker, circulates in the blood bound mainly to low-density lipoprotein (LDL) and promotes vascular inflammation. Several epidemiological studies have shown that circulating levels of Lp-PLA(2) are an independent risk factor for cardiovascular events. Recent studies demonstrate that Lp-PLA(2) is also associated with endothelial dysfunction and early atherosclerosis. This review provides an overview of these studies, suggests plausible mechanisms for the association between endothelial dysfunction and Lp-PLA(2), and highlights future potential therapies.
Lavi
Shahar
S
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
Lavi
Ronit
R
McConnell
Joseph P
JP
Lerman
Lilach O
LO
Lerman
Amir
A
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D003327:Coronary Disease / Q000201:enzymology* / Q000503:physiopathology* / Q000628:therapy; D004730:Endothelium, Vascular / Q000201:enzymology* / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation
D015415:Biomarkers; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase
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