CSF cortisol in Alzheimer's disease and mild cognitive impairment.
Hypercortisolaemia occurs in Alzheimer's disease (AD) and may be involved in the AD related neurodegenerative process. In order to determine whether brain structures are exposed to high cortisol concentrations early in AD, we measured cerebrospinal fluid (CSF) cortisol in 66 subjects with AD, 33 subjects with mild cognitive impairment (MCI) and 34 control subjects. CSF cortisol concentrations were higher in AD subjects compared to controls (p<0.001) and to MCI subjects (p=0.002). There was no significant increase of cortisol in MCI subjects compared with controls suggesting that the increase of CSF cortisol is not an early event in the course of AD.
Popp
Julius
J
Department of Psychiatry, University of Bonn, Bonn, Germany. Julius.Popp@ukb.uni-bonn.de
Schaper
Karsten
K
Kölsch
Heike
H
Cvetanovska
Gabriela
G
Rommel
Fatima
F
Klingmüller
Dietrich
D
Dodel
Richard
R
Wüllner
Ullrich
U
Jessen
Frank
F
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000523:psychology; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D006854:Hydrocortisone / Q000134:cerebrospinal fluid*; D009483:Neuropsychological Tests
D015415:Biomarkers; D006854:Hydrocortisone