The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes.
To ensure an adequate response against pathogens and prevent unwanted self-reactivity, immune cells need to functionally express both activating and inhibitory receptors. CD200R is an inhibitory receptor mainly expressed on myeloid cells that down-modulates cellular activation both in vivo and in vitro. Although previously mainly studied as a regulator of myeloid function, we now show that CD200R is differentially expressed on human and mouse T-cell subsets. In both species, CD4+ T cells express higher amounts of CD200R than CD8+ T cells, and memory cells express higher amounts of CD200R than naïve or effector cells. CD200R expression is up-regulated on both CD4+ and CD8+ T cells after stimulation in vitro. Furthermore, we show CD200R expression on human and mouse B cells. In human tonsils, CD200R is differentially expressed on B cells, with high expression on memory cells and plasmablasts. Mice lacking the ligand for CD200R, CD200-/- mice, do not show abnormal composition of the lymphocyte compartment and have normal B cell responses to antigenic challenge. Although the functional implications remain to be elucidated, the expression of CD200R on lymphocytes suggests a much broader role for CD200R-mediated immune regulation than previously anticipated.
Rijkers
Eva S K
ES
Department of Immunology, UMC Utrecht, Utrecht, The Netherlands.
de Ruiter
Talitha
T
Baridi
Ajoeb
A
Veninga
Henrike
H
Hoek
Robert M
RM
Meyaard
Linde
L
D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D000954:Antigens, Surface / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D064446:Orexin Receptors; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D016176:T-Lymphocyte Subsets / Q000378:metabolism*
D015703:Antigens, CD; D000954:Antigens, Surface; C477337:CD200R1 protein, human; C501103:Cd200r1 protein, mouse; D064446:Orexin Receptors; D011956:Receptors, Cell Surface; C042739:antigens, CD200