Effect of oral aluminium hydroxide on iron absorption from iron(III)-hydroxide polymaltose complex in patients with iron deficiency anemia / a single-centre randomized controlled isotope study.
The study was carried out as an open-label, laboratory-blind, single-dose, randomized, two-period crossover, isotope efficacy study. Twenty-two patients with iron-deficiency anemia were enrolled in the study. The study consisted of two treatment phases of 15 days each, including blood sample measurements for Fe-59 activity. The 2 treatments were given orally. Treatment A was Fe-59 labeled iron(III)-hydroxide polymaltose complex (IPC, Maltofer), equivalent to 100 mg elemental iron given orally, and Treatment B consisted of Treatment A combined with 600 mg aluminium hydroxide (CAS 21645-51-2) (10 ml). No differences between the two treatment groups with regard to the erythrocyte uptake were found, and thus IPC can be used with aluminium hydroxide, if necessary.
Potgieter
Maria A
MA
Farmovs-Parexel, Bloemfontein, South Africa. Linda.Potgieter@PAREXEL.com
Potgieter
Johannes H
JH
Venter
Cornea
C
Venter
Jan L
JL
Geisser
Peter
P
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy*; D000818:Animals; D000863:Antacids / Q000494:pharmacology*; D019540:Area Under Curve; D001682:Biological Availability; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D019587:Dietary Supplements; D004311:Double-Blind Method; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005290:Ferric Compounds / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D005293:Ferritins / Q000097:blood; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007501:Iron / Q000493:pharmacokinetics*; D007504:Iron Radioisotopes; D008297:Male; D051379:Mice; D008875:Middle Aged; D011786:Quality Control; D051381:Rats
D000863:Antacids; D005290:Ferric Compounds; D007504:Iron Radioisotopes; D000536:Aluminum Hydroxide; D005293:Ferritins; D007501:Iron; C013276:teferrol