[Pilot study of a cell membrane like biomimetic drug-eluting coronary stent].
A novel bioinspired phospholipid copolymer has been synthesized by the radical polymerization of poly2-Methacryloyloxyethylphosphorylcholine (MPC), stearyl methacrylate (SMA), hydroxypropyl methacrylate (HPMA) and trimethoxysilylpropyl methacrylate (TSMA). Contact angle results indicated that the coating surface rearranged to get a more hydrophilic surface at the polymer/water interface. The membrane mimic phosphorylcholine coating surface could resist the platelet adhesion and prolong plasma recalcification time significantly. Rapamycin was used as model drugs to prepare drug-eluting coating. The animal experiments showed that this novel drug-eluting stent could effectively prevent the phenomena of restenosis.
Fan
Dezeng
D
Advanced Technology & Materials Co., Ltd, Beijing 100081, China. fandezeng@aqtmcn.com
Jia
Zhiyuan
Z
Yan
Xinhao
X
Liu
Xiaolei
X
Dong
Wei
W
Sun
Fuyu
F
Ji
Jian
J
Xu
Jianping
J
Ren
Kefeng
K
Chen
Weidong
W
Shen
Jiacong
J
Qiu
Hong
H
Gao
Runlin
R
D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D000818:Animals; D020099:Coated Materials, Biocompatible; D023903:Coronary Restenosis / Q000517:prevention & control*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D010865:Pilot Projects; D011108:Polymers / Q000737:chemistry; D011474:Prosthesis Design; D011897:Random Allocation; D020123:Sirolimus / Q000737:chemistry; D013552:Swine; D013556:Swine, Miniature
D020099:Coated Materials, Biocompatible; D008689:Methacrylates; D011108:Polymers; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine; C032802:hydroxypropyl methacrylate; D020123:Sirolimus