title: Epigenetic transgenerational toxicology and germ cell disease.
abstract: The ability of an environmental exposure (i.e. endocrine disruptor) during sex determination to reprogramme the male germline and promote an epigenetic transgenerational disease phenotype suggests that environmental factors and compounds may permanently alter the germline epigenome. This epigenetic transgenerational phenomenon will be discussed with respect to adult-onset germline disease (e.g. testicular cancer). A thorough literature review is not provided, rather a perspective is provided on how this epigenetic transgenerational toxicology should be considered in germ cell disease and testicular cancer.
authors: Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA, USA. skinner@mail.wsu.edu
authors: Michael K
authors: MK
authors: Skinner
mesh_terms: D019175:DNA Methylation; D004781:Environmental Exposure; D044127:Epigenesis, Genetic / Q000235:genetics*; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D013736:Testicular Neoplasms / Q000235:genetics*
references: Pediatr Res. 2004 Sep;56(3):311-7
references: 15240866
references: Carcinogenesis. 1998 Sep;19(9):1655-63
references: 9771938
references: Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12207-12
references: 14506296
references: Semin Pediatr Neurol. 2001 Sep;8(3):128-34
references: 11575842
references: Science. 2005 Jun 3;308(5727):1466-9
references: 15933200
references: Cancer Res. 2006 Jun 1;66(11):5624-32
references: 16740699
references: Proc Natl Acad Sci U S A. 2002 May 14;99(10):6877-82
references: 11997464
references: Endocrinology. 2006 Dec;147(12 ):5524-41
references: 16973722
references: Toxicol Appl Pharmacol. 1994 Jun;126(2):276-85
references: 8209380
references: Birth Defects Res A Clin Mol Teratol. 2005 Mar;73(3):131-2
references: 15751038
references: Endocrinology. 2006 Jun;147(6 Suppl):S43-9
references: 16690803
references: Endocrinology. 2006 Dec;147(12 ):5515-23
references: 16973726
references: J Physiol. 2005 Jul 1;566(Pt 1):225-36
references: 15860532
references: Hum Reprod Update. 2006 May-Jun;12(3):303-23
references: 16540528
references: J Androl. 2006 Nov-Dec;27(6):868-79
references: 16837734
references: Cell Tissue Res. 2005 Oct;322(1):159-65
references: 15846514
references: J Nutr. 2002 Aug;132(8 Suppl):2388S-2392S
references: 12163698
references: Genet Med. 2003 Sep-Oct;5(5):347-52
references: 14501829