title: Balanced production of ribosomal proteins.
abstract: Eukaryotic ribosomes contain one molecule each of 79 different proteins. The genes encoding these proteins are usually at widely scattered loci and have distinctive promoters with certain common features. This minireview discusses the means by which cells manage to balance the production of ribosomal proteins so as to end up with equimolar quantities in the ribosome. Regulation at all levels of gene expression, from transcription to protein turnover, is considered.
authors: Fox Chase Cancer Center, Philadelphia, PA 19111, USA. RP_Perry@fccc.edu
authors: Robert P
authors: RP
authors: Perry
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells / Q000737:chemistry; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D014176:Protein Biosynthesis / Q000502:physiology*; D012269:Ribosomal Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D012270:Ribosomes / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D012269:Ribosomal Proteins
references: J Mol Biol. 1977 Sep 25;115(3):315-33
references: 592369
references: BMC Neurosci. 2002;3:3
references: 11922865
references: Genetics. 2005 Apr;169(4):1915-25
references: 15716499
references: Genes Dev. 2004 Oct 15;18(20):2431-6
references: 15489289
references: Mol Syst Biol. 2006;2:63
references: 17102808
references: Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3889-94
references: 12660367
references: Cell. 1998 Nov 25;95(5):717-28
references: 9845373
references: Enzyme. 1990;44(1-4):93-105
references: 2133662
references: Mol Cell. 2004 Jul 2;15(1):5-15
references: 15225544
references: Development. 2004 Aug;131(16):3907-20
references: 15289434
references: Proc Natl Acad Sci U S A. 1986 Aug;83(16):5854-7
references: 3526341
references: J Mol Biol. 1971 Jan 14;55(1):129-34
references: 5102271
references: Mol Cell Biol. 2006 Dec;26(23):8880-91
references: 17000767
references: Mol Cell Biol. 1987 Aug;7(8):2691-9
references: 3670289
references: Gene. 2003 Nov 27;320:41-8
references: 14597387
references: PLoS Biol. 2004 May;2(5):E139
references: 15138505
references: RNA. 2005 Oct;11(10):1521-9
references: 16199762
references: Nat New Biol. 1971 Jan 20;229(3):75-80
references: 5280340
references: Trends Biochem Sci. 1999 Nov;24(11):437-40
references: 10542411
references: Mol Cell Biol. 1999 Jan;19(1):826-34
references: 9858605
references: Bioinformatics. 2001 Dec;17(12):1152-7
references: 11751223
references: J Biol Chem. 1987 Apr 5;262(10):4868-75
references: 3558374
references: Br J Haematol. 2006 Oct;135(2):149-57
references: 16942586
references: Genetics. 1998 Mar;148(3):1215-24
references: 9539436
references: Mol Cell Biol. 1988 Jan;8(1):169-75
references: 3275866
references: Blood. 2007 Feb 1;109(3):1275-83
references: 17053056
references: Eur J Biochem. 2000 Nov;267(21):6321-30
references: 11029573
references: Genes Dev. 1995 Feb 1;9(3):304-16
references: 7867928
references: BMC Evol Biol. 2005 Feb 13;5:15
references: 15707503
references: Trends Biochem Sci. 1996 May;21(5):164-5
references: 8871397
references: EMBO J. 1995 Aug 15;14(16):4022-30
references: 7664741
references: BMC Genomics. 2006 Feb 28;7:37
references: 16504170
references: Mol Cell Biol. 2006 Jul;26(13):4853-62
references: 16782874
references: Genes Dev. 2007 Jan 15;21(2):137-42
references: 17234880