A validated UV spectrophotometric method for estimation of nebivolol hydrochloride in bulk and pharmaceutical formulation.
A simple, sensitive and accurate UV spectrophotometric method was developed for the assay of nebivolol hydrochloride in raw material and tablets. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 282 nm for nebivolol hydrochloride tablet solution. The linearity range was found to be 5-50 microg/mL for the drug. It was found that the excipients present in the commercial formulation did not interfere with the method.
Kamila
M M
MM
Pharmaceutics Research Laboratory-II, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Mondal
N
N
Ghosh
L K
LK
Gupta
B K
BK
D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D001578:Benzopyrans / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D004983:Ethanolamines / Q000032:analysis*; D000068577:Nebivolol; D015203:Reproducibility of Results; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D012996:Solutions; D013607:Tablets; D000068577:Nebivolol