[The role of the serotoninergic system in the pathogenesis of experimental ulcerous colitis].
Ulcerous colitis was modeled in a rat experiment by introducing picrylsulfonic acid. The role of serotoninergic structures in the pathogenesis of ulcerous colitis was studied by preliminary administration of serotonin or spiperone, a 5-HT2 serotonin blocker. Spiperone was shown to inhibit the damaging action of picrylsulfonic acid during the first ten days of the beginning of modeling, and to accelerate reparative processes.
Lazebnik
L B
LB
Lychkova
A E
AE
Potapova
V B
VB
D000818:Animals; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D004195:Disease Models, Animal; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism* / Q000627:therapeutic use; D013134:Spiperone / Q000627:therapeutic use*; D016896:Treatment Outcome; D014302:Trinitrobenzenesulfonic Acid / Q000633:toxicity
D018492:Dopamine Antagonists; D012701:Serotonin; D013134:Spiperone; D014302:Trinitrobenzenesulfonic Acid