title: On the mutagenic action of adenine.
abstract: The deamination of cytosine and adenine is mutagenic; the deamination of guanine is not. The deamination of cytosine leads to G=C-->A=T point mutation and to G-->A and C-->T transition in the DNA molecule; the deamination of adenine leads to the opposite A-->G and T-->C transition. It is shown that adenine lack could be as mutagenic as adenine deamination and it is also shown schematically that adenine lack through defective adenine synthesis could give rise to a population of genetically abnormal cells incapable of any degree of differentiation, a state perhaps reminiscent of the most acute of leukaemias and the most anaplastic of cancers.
authors: Awelon, Penyturnpike Road, DINAS POWlS, Vale of Glamorgan CF64 4HG, Wales, UK. UKMDSFORUM@aol.com
authors: T E
authors: TE
authors: Parry
mesh_terms: D000225:Adenine / Q000378:metabolism*; D003596:Cytosine; D004247:DNA / Q000235:genetics; D003641:Deamination; D006801:Humans; D019271:Hypoxanthine / Q000378:metabolism; D016296:Mutagenesis; D017354:Point Mutation
chemical_list: D019271:Hypoxanthine; D003596:Cytosine; D004247:DNA; D000225:Adenine