title: In silico comparison of pKLC102-like genomic islands of Pseudomonas aeruginosa.
abstract: The genomic island pKLC102 first detected in Pseudomonas aeruginosa clone C strains can cross species barriers and exhibits the highest mobilization rate of a genomic island known to date. Homologous genomic islands of 81-108 kb in size were identified in the completely sequenced P. aeruginosa strains PA7, PA14, 2192, C3719 and PACS2, but not in strains PAO1 and LES. All pKLC102-like genomic islands are integrated in chromosomal tRNA(Lys) genes and share a syntenic set of more than 70 homologous ORFs, part of which are related to DNA replication or mobility genes. The conserved backbone has predilection sites for the uptake of island-specific gene cassettes. A major difference between the islands is the organization of the origin of replication oriV.
authors: Klinische Forschergruppe, OE 6711, Medizinische Hochschule Hannover, Hannover, Germany.
authors: Dieco
authors: D
authors: Würdemann
authors: Burkhard
authors: B
authors: Tümmler
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D022761:Gene Transfer, Horizontal; D016680:Genome, Bacterial; D044404:Genomic Islands / Q000235:genetics*; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis; D016366:Open Reading Frames; D010957:Plasmids; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011550:Pseudomonas aeruginosa / Q000145:classification* / Q000235:genetics*; D012357:RNA, Transfer, Lys; D018741:Replication Origin; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D001426:Bacterial Proteins; D012357:RNA, Transfer, Lys