Guinea Pig Maximization Test of tri-ethylene glycol mono-methacrylate.
The aim of this study was to evaluate tri-ethylene glycol mono-methacrylate (TEGMA) in terms of dermatological allergic reaction using a Guinea Pig Maximization Test. Skin reaction was evaluated according to the criteria of International Contact Dermatitis Research Group. TEGMA, as a constituent in new primers, has been reported to contribute to a priming ability similar to that of highly purified glyceryl mono-methacrylate (GM). In this study, it was found that its adverse effect was less than that of 2-hydroxy ethyl methacrylate (2-HEMA), but similar to that of highly purified GM. In conclusion, it was anticipated that TEGMA would hereafter replace 2-HEMA as a primer, as it posed a lower risk of triggering dermatological allergic reaction.
Akiyama
Takashi
T
Department of Clinical Cariology and Endodontology, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ohta-Ward, Tokyo 145-8515, Japan. akiyama@senzoku.showa-u.ac.jp
Manabe
Atsufumi
A
Tani
Chihiro
C
Takahashi
Yoichi
Y
Itoh
Kazuo
K
Hisamitsu
Hisashi
H
D000818:Animals; D017220:Dentin-Bonding Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005989:Glycerides / Q000009:adverse effects; D006168:Guinea Pigs; D008689:Methacrylates / Q000009:adverse effects; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011109:Polymethacrylic Acids / Q000009:adverse effects*
D017220:Dentin-Bonding Agents; D005989:Glycerides; D008689:Methacrylates; D011109:Polymethacrylic Acids; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; C069750:glyceryl methacrylate; C005044:hydroxyethyl methacrylate