Predictors of gastrointestinal perforation in patients undergoing coronary artery bypass graft (CABG) surgery in Tehran, Iran.
BACKGROUND
Gastrointestinal perforation after coronary artery bypass graft (CABG) surgery is often difficult to diagnose and is associated with high morbidity and mortality rates. The aim of this study was to determine risk factors for this complication in the studied population to further improve prophylaxis and diagnosis in the region of study.


METHODS
Of 8,975 consecutive patients undergoing CABG during 10 years (1995-2005), 15 (0.16%) developed gastrointestinal perforation requiring laparatomy. Data from patients who experienced gastrointestinal perforation were analyzed using univariate tests in a controlled retrospective design.


RESULTS
Prolonged bypass time and preoperative heparin administration were found to be significant (P<0.05) risk factors.


CONCLUSIONS
Low splanchnic blood flow and vasoconstriction might be underlying factors associated with both predictors. With current findings, however, clear inference about preoperative and postoperative predictors and their relation is not possible. With more information, the next step would be to build a prediction model in recognition of gastrointestinal perforation after CABG on the basis of the predisposing factors.
Alebouyeh
Nouredin
N
School of Medicine, Shahid Beheshti University of Medical Sciences and Health Care, Tehran, Iran.
Toefigh
Mehrdad
M
Ghasemzadeh
Nima
N
Mirheydari
Samineh
S
Azargashb
Ezonollah
E
D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D001026:Coronary Artery Bypass; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000209:etiology*; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007416:Intestinal Perforation / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012307:Risk Factors; D013275:Stomach Rupture / Q000175:diagnosis / Q000209:etiology
D006493:Heparin