The transcription profile of the bocavirus bovine parvovirus is unlike those of previously characterized parvoviruses.
The Bocavirus bovine parvovirus generated a single pre-mRNA from a promoter at its left-hand end; however, the pattern of its alternative polyadenylation and splicing was different from that of other parvoviruses. A large left-hand-end open reading frame (ORF) encoded a nonstructural protein of approximately 95 kDa. An abundant, spliced, internally polyadenylated transcript encoded the viral NP1 protein from an ORF in the center of the genome. Transcripts encoding the capsid proteins were polyadenylated in the right-hand terminal palindrome. This is the first published transcription map of a member of the Bocavirus genus of the Parvovirinae.
Qiu
Jianming
J
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA. jqiu@kumc.edu
Cheng
Fang
F
Johnson
F Brent
FB
Pintel
David
D
D001483:Base Sequence; D052660:Bocavirus / Q000235:genetics*; D002460:Cell Line; D003001:Cloning, Molecular; D016679:Genome, Viral; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D017992:Parvovirus / Q000235:genetics*; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000378:metabolism; D013045:Species Specificity; D014158:Transcription, Genetic
D012333:RNA, Messenger
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