title: Safety and efficiency of recombinant activated factor VII in postcardiotomy massive hemorrhage.
abstract: Postoperative massive hemorrhage is a difficult clinical situation after cardiac surgery. Recombinant activated factor VII (rf-VIIa) can be a useful adjunct to surgical hemostasis and blood product transfusion. Four cases of massive hemorrhage treated with rf-VIIa after complex cardiac surgery are reported. A review of the literature and possible guidelines for the use of rf-VIIa in cardiac surgery are provided.
authors: Department of Surgery, Montreal Heart Institute and Université de Montréal, Montreal, QC, Canada. rc2910@aol.com
authors: Yoan
authors: Y
authors: Lamarche
authors: Philippe
authors: P
authors: Demers
authors: Nancy C
authors: NC
authors: Poirier
authors: Danielle
authors: D
authors: Robitaille
authors: Raymond
authors: R
authors: Cartier
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D003029:Coagulants; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D003029:Coagulants; D011994:Recombinant Proteins; D015942:Factor VIIa
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