title: The anti-cancer effects of quinolone antibiotics?
abstract: A previous meta-analysis showed that quinolones administered for prophylaxis of infections among cancer patients reduced all-cause mortality. We extracted from the primary trials infection-related and all-cause mortality as reported and assessed the effect of quinolones on non-infection-related mortality through meta-analysis. Among trials comparing quinolones to placebo or no treatment, a significant reduction in non-infection-related mortality was observed (relative risk 0.54, 95% confidence interval 0.32-0.93, 15 trials, 3,320 patients). This finding might represent biased attribution of deaths to infection or might be compatible with an anti-cancer effect of quinolone antibiotics. We present further analyses addressing these possibilities.
authors: Department of Medicine E and Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, 49100, Israel. pil1pel@zahav.net.il
authors: M
authors: M
authors: Paul
authors: A
authors: A
authors: Gafter-Gvili
authors: A
authors: A
authors: Fraser
authors: L
authors: L
authors: Leibovici
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D015363:Quinolones / Q000627:therapeutic use*
chemical_list: D000903:Antibiotics, Antineoplastic; D015363:Quinolones
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