title: Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection.
abstract: Glucosylceramides (GlcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.
authors: Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil. marcio@micro.ufrj.br
authors: Marcio L
authors: ML
authors: Rodrigues
authors: Li
authors: L
authors: Shi
authors: Eliana
authors: E
authors: Barreto-Bergter
authors: Leonardo
authors: L
authors: Nimrichter
authors: Sandra E
authors: SE
authors: Farias
authors: Elaine G
authors: EG
authors: Rodrigues
authors: Luiz R
authors: LR
authors: Travassos
authors: Joshua D
authors: JD
authors: Nosanchuk
mesh_terms: D000818:Animals; D000908:Antibodies, Fungal / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D000946:Antigens, Fungal / Q000276:immunology*; D002554:Cerebrosides / Q000276:immunology*; D003453:Cryptococcosis / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D003455:Cryptococcus neoformans / Q000276:immunology*; D005260:Female; D051379:Mice; D008805:Mice, Inbred A
chemical_list: D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal; D000946:Antigens, Fungal; D002554:Cerebrosides; C013870:ceramide monohexoside
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