Intraventricular hemorrhage from ruptured aneurysm: clinical characteristics, complications, and outcomes in a large, prospective, multicenter study population.
OBJECTIVE
In this study the authors analyzed the relationship of intraventricular hemorrhage (IVH) to in-hospital complications and clinical outcome in a large population of patients with aneurysmal subarachnoid hemorrhage (SAH).


METHODS
Data from 3539 patients with aneurysmal SAH were evaluated, and these data were obtained from four prospective, randomized, double-blind, placebo-controlled trials of tirilazad that had been conducted between 1991 and 1997. Clinical characteristics, in-hospital complications, and outcome at 3 months post-SAH (Glasgow Outcome Scale score) were analyzed with regard to the presence or absence of IVH.


RESULTS
Patients with SAH and IVH differ in demographic and admission characteristics from those with SAH but without IVH and are more likely to suffer in-hospital complications and a worse outcome at 3 months post-SAH.


CONCLUSIONS
The presence of IVH in patients with SAH has an important predictive value with regard to these aspects.
Rosen
David S
DS
Department of Surgery, Section of Neurosurgery, Neurocritical Care and Acute Stroke Program, University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA.
Macdonald
R Loch
RL
Huo
Dezheng
D
Goldenberg
Fernando D
FD
Novakovic
Roberta L
RL
Frank
Jeffrey I
JI
Rosengart
Axel J
AJ
D000328:Adult; D000368:Aged; D017542:Aneurysm, Ruptured / Q000150:complications*; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D015331:Cohort Studies; D004311:Double-Blind Method; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications*; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use; D011281:Pregnatrienes / Q000627:therapeutic use; D011379:Prognosis; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy
D018696:Neuroprotective Agents; D011281:Pregnatrienes; C053355:tirilazad