Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis.
Enzymes in the matrix metalloproteinase (MMP) family have been linked to key events in developmental biology for almost 50 years. Biochemical, cellular and in vivo analyses have established that pericellular proteolysis contributes to numerous aspects of ontogeny including ovulation, fertilization, implantation, cellular migration, tissue remodeling and repair. Surface anchoring of proteinase activity provides spatial restrictions on substrate targeting. This review will utilize membrane type 1 MMP (MT1-MMP) as an example to highlight substrate diversity in pericellular proteolysis catalyzed by a membrane anchored MMP.
Barbolina
Maria V
MV
Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA.
Stack
M Sharon
MS
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism*; D006801:Humans; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D011509:Proteoglycans / Q000378:metabolism; D013379:Substrate Specificity
D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D011509:Proteoglycans; D053511:Matrix Metalloproteinase 14
J Biol Chem. 2002 Mar 1;277(9):7377-85
11741954
J Biol Chem. 2002 Mar 22;277(12):9749-56
11724803
J Cell Biol. 2002 Apr 29;157(3):493-507
11970960
Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14
11994741
Essays Biochem. 2002;38:21-36
12463159
Curr Top Dev Biol. 2003;54:1-74
12696745
Cancer Lett. 2003 May 8;194(1):1-11
12706853
Cancer Res. 2003 May 1;63(9):2292-9
12727852
Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2550-6
12766056
Cell. 2003 Jul 11;114(1):33-45
12859896
J Biol Chem. 2003 Oct 17;278(42):40764-70
12904296
Blood. 2003 Nov 1;102(9):3262-9
12855577
Exp Cell Res. 2003 Nov 15;291(1):167-75
14597417
J Urol. 2003 Dec;170(6 Pt 1):2248-52
14634390
J Biol Chem. 2004 Feb 6;279(6):4260-8
14645246
Br J Cancer. 2004 Feb 9;90(3):561-5
14760364
FASEB J. 2004 Feb;18(2):364-6
14688206
Biochemistry. 1996 Oct 8;35(40):13056-63
8855941
Immunol Today. 1996 Nov;17(11):532-40
8961631
J Biol Chem. 1997 Jan 24;272(4):2446-51
8999957
Lab Invest. 1997 May;76(5):651-60
9166284
J Cell Biol. 1997 Dec 1;139(5):1349-60
9382879
Cell. 1997 Nov 14;91(4):439-42
9390552
Eur J Biochem. 1997 Dec 15;250(3):751-7
9461298
J Biol Chem. 1998 Feb 6;273(6):3604-10
9452488
Biochem J. 1998 Sep 1;334 ( Pt 2):345-53
9716492
J Cell Sci. 1998 Sep;111 ( Pt 18):2789-98
9718371
Cell. 1998 Oct 30;95(3):365-77
9814707
J Biol Chem. 1999 May 7;274(19):13613-8
10224132
J Biol Chem. 1999 Aug 6;274(32):22679-85
10428849
Bioessays. 1999 Nov;21(11):940-9
10517867
Cell. 1999 Oct 1;99(1):81-92
10520996
Biochemistry. 1999 Oct 19;38(42):13928-36
10529239
Proc Natl Acad Sci U S A. 1962 Jun 15;48:1014-22
13902219
Onkologie. 2004 Dec;27(6):577-82
15591720
J Cell Biol. 2000 Feb 7;148(3):615-24
10662785
J Cell Biol. 2000 Feb 21;148(4):825-38
10684262
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4052-7
10737763
J Biol Chem. 2000 Apr 21;275(16):12080-9
10766841
Adv Exp Med Biol. 2000;477:217-28
10849749
J Cell Biol. 2000 Jun 12;149(6):1309-23
10851027
Mol Biol Cell. 2000 Jul;11(7):2387-401
10888676
J Biol Chem. 2000 Oct 20;275(42):33008-13
10930399
J Biol Chem. 2000 Dec 15;275(50):39497-506
10991943
Arthritis Rheum. 2001 Feb;44(2):253-9
11229454
Front Biosci. 2001 Mar 1;6:D417-28
11229872
Arch Biochem Biophys. 2001 Jun 1;390(1):51-6
11368514
J Biol Chem. 2001 May 25;276(21):18415-22
11278623
J Cell Biol. 2001 May 28;153(5):893-904
11381077
J Thromb Haemost. 2006 Jul;4(7):1484-6
16839342
J Cell Sci. 2006 Sep 15;119(Pt 18):3822-32
16926191
Cancer Res. 2006 Nov 1;66(21):10460-5
17079467
J Biol Chem. 2006 Nov 24;281(47):35593-7
17005550
J Biol Chem. 2006 Dec 1;281(48):36846-55
17018528
Mol Biol Cell. 2006 Dec;17(12):5390-9
17050733
J Biol Chem. 2006 Dec 8;281(49):37576-85
17050542
J Biol Chem. 2007 Feb 16;282(7):4924-31
17158885
Cancer Res. 2007 Mar 1;67(5):2030-9
17332331
Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1615-21
17389491
J Mol Biol. 2007 May 11;368(4):1101-13
17379243
Am J Pathol. 2007 Jun;170(6):2100-11
17525276
Biochem J. 2007 Oct 15;407(2):171-7
17650075
J Biol Chem. 2002 May 17;277(20):17511-9
11891230
J Biol Chem. 2002 Jul 19;277(29):26340-50
12004057
Blood. 2002 Aug 15;100(4):1160-7
12149192
J Biol Chem. 2002 Oct 11;277(41):39005-14
12145314
Cancer Res. 2004 Feb 1;64(3):876-82
14871815
J Biol Chem. 2004 Feb 27;279(9):8278-89
14670950
J Biol Chem. 2004 Feb 27;279(9):7721-33
14672946
Clin Exp Metastasis. 2004;21(1):75-8
15065605
Proc Natl Acad Sci U S A. 2004 May 4;101(18):6917-22
15118097
J Cell Physiol. 2004 Jul;200(1):2-10
15137052
Anticancer Res. 2004 May-Jun;24(3b):2027-31
15274395
Biochem J. 2004 Aug 15;382(Pt 1):363-73
15130087
Endocrinology. 2004 Sep;145(9):4192-203
15142990
Cancer Res. 2004 Oct 1;64(19):7058-64
15466200
J Biol Chem. 2004 Oct 8;279(41):43336-44
15292230
Cell Biol Int Rep. 1985 Dec;9(12):1097-107
3000628
J Biol Chem. 1993 Jul 5;268(19):14033-9
8314771
Nature. 1994 Jul 7;370(6484):61-5
8015608
J Biol Chem. 1995 Mar 10;270(10):5331-8
7890645
FEBS Lett. 1996 May 6;385(3):238-40
8647259
FEBS Lett. 1996 Sep 9;393(1):101-4
8804434
J Cell Sci. 2005 Jan 1;118(Pt 1):147-56
15601659
EMBO J. 2005 Feb 23;24(4):742-52
15692570
Curr Pharm Des. 2005;11(7):881-91
15777241
Biochimie. 2005 Mar-Apr;87(3-4):361-8
15781323
Neoplasia. 2005 Apr;7(4):380-9
15967115
J Biol Chem. 2005 Jul 1;280(26):25079-86
15878869
Cancer Metastasis Rev. 2005 Jun;24(2):195-222
15986132
Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9182-7
15958533
J Biol Chem. 2005 Jul 15;280(28):26160-8
15901740
J Biol Chem. 2006 Mar 10;281(10):6826-40
16407177
Exp Oncol. 2006 Mar;28(1):83-5
16614715
Cell. 2006 May 5;125(3):577-91
16678100
Skin Pharmacol Physiol. 2006;19(2):65-70
16685144
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9017-22
16754882
Pathol Int. 2006 Jul;56(7):359-67
16792544
J Biol Chem. 2002 Nov 15;277(46):44061-7
12226090
Biol Chem. 2002 Jul-Aug;383(7-8):1095-105
12437092
FEBS Lett. 2002 Dec 4;532(1-2):127-30
12459476
Nature. 2005 Jul 14;436(7048):193-200
16015319
Cancer. 2005 Aug 15;104(4):740-6
15991243
Mol Cancer Ther. 2005 Aug;4(8):1157-66
16093431
J Cell Sci. 2005 Nov 1;118(Pt 21):4975-84
16219679
Am J Physiol Renal Physiol. 2006 Jan;290(1):F43-51
16077081
J Biol Chem. 2005 Dec 23;280(51):42237-41
16251193
J Neurosci. 2006 Feb 22;26(8):2300-12
16495457
J Biol Chem. 2001 Jul 6;276(27):24833-42
11331272
Cancer Res. 2001 Sep 1;61(17):6322-7
11522618
EMBO J. 2001 Sep 3;20(17):4782-93
11532942
J Biol Chem. 2001 Nov 23;276(47):43503-8
11571304
J Exp Med. 2002 Feb 4;195(3):295-308
11828004