title: The treatment of psychotic major depression: is there a role for adjunctive psychotherapy?
abstract: BACKGROUND
  Psychotic depression is a relatively prevalent mood disorder associated with greater symptom severity, a poorer course of illness and higher levels of functional impairment compared with nonpsychotic depression. Separate lines of investigation suggest that various forms of cognitive-behavioral therapy are efficacious for treating severe forms of nonpsychotic depression as well as primary psychotic disorders. However, there currently are no empirically supported psychotherapies specifically designed for treating psychotic depression.
  
  
  METHODS
  We review the efficacy of current somatic treatments for the disorder and discuss the limited data to date on potentially useful psychotherapeutic approaches. In particular, we describe the clinical improvement observed in a subgroup of hospitalized patients with psychotic depression treated with Acceptance and Commitment Therapy as part of a larger clinical trial.
  
  
  RESULTS
  Pilot results demonstrated that Acceptance and Commitment Therapy was associated with clinically significant reductions in acute symptom severity and impairment compared with treatment as usual.
  
  
  CONCLUSIONS
  The findings suggest that patients with psychotic depression can benefit from psychotherapy. Clinical and research recommendations in this area are presented.
authors: Department of Psychiatry and Human Behavior, Brown Medical School and Butler Hospital, Providence, RI 02906, USA. Brandon_Gaudiano@brown.edu
authors: Brandon A
authors: BA
authors: Gaudiano
authors: Ivan W
authors: IW
authors: Miller
authors: James D
authors: JD
authors: Herbert
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000453:epidemiology* / Q000534:rehabilitation / Q000628:therapy*; D006760:Hospitalization; D006801:Humans; D009483:Neuropsychological Tests; D010865:Pilot Projects; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000534:rehabilitation / Q000628:therapy*
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents