Adducts of uridine and glycals as potential substrates for glycosyltransferases.
We report on the synthesis of 2-deoxyglycosyl derivatives of uridine as potential donor substrates for glycosyltransferases. The totally stereoselective synthesis is accomplished by two sequential addition reactions of uridine derivatives to glycals promoted by triphenylphosphine-hydrogen bromide.
Wandzik
Ilona
I
Silesian University of Technology, Faculty of Chemistry, Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, 44-100 Gliwice, Krzywoustego 4, Poland. ilona.wandzik@polsl.pl
Bieg
Tadeusz
T
D011756:Diphosphates / Q000737:chemistry; D005690:Galactose / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry; D006031:Glycosylation; D016695:Glycosyltransferases / Q000737:chemistry*; D018054:Hydrobromic Acid / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009943:Organophosphorus Compounds / Q000737:chemistry; D013237:Stereoisomerism; D014529:Uridine / Q000737:chemistry*
D011756:Diphosphates; D006027:Glycosides; D009943:Organophosphorus Compounds; C061896:triphenylphosphine; D018054:Hydrobromic Acid; D016695:Glycosyltransferases; D005947:Glucose; D014529:Uridine; D005690:Galactose