Lack of association between thrombosis-associated and cytokine candidate gene polymorphisms and acute rejection or vascular complications after kidney transplantation.
BACKGROUND
Acute rejection episodes and vascular complications are common after renal transplantation and have negative impact on the long-term patient and graft survival. We investigated whether the risks of acute rejection, thrombosis, infarction and graft loss could be predicted based on the presence of functional polymorphisms in the genes of the coagulation and endothelial inflammation cascade.


METHODS
The study consisted of 772 consecutive cadaver kidney transplantations from a single centre. The effects of gene polymorphisms FVL, F5R2, FII G20210A, MTHFR C677T, F13A1 V34L, TFPI P151L, PROC W380G, TNF G(-308)A, IL10 A(-592)C, IL10 A(-1082)G and IL6 C(-174)G of recipients and donors were investigated.


RESULTS
We were unable to find statistically significant associations between any of the studied polymorphisms and clinical outcomes.


CONCLUSIONS
Our results indicate that high-risk renal transplant candidates cannot be identified through the routine analysis of the polymorphisms.
Alakulppi
Noora S
NS
Research and Development, Finnish Red Cross Blood Service, Kivihaantie 7, Helsinki, Finland .
Kyllönen
Lauri E
LE
Partanen
Jukka
J
Salmela
Kaija T
KT
Laine
Jarmo T
JT
D000208:Acute Disease; D002102:Cadaver; D016207:Cytokines / Q000235:genetics*; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D007238:Infarction / Q000453:epidemiology / Q000235:genetics*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011183:Postoperative Complications / Q000453:epidemiology; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology / Q000235:genetics*; D014652:Vascular Diseases / Q000453:epidemiology / Q000235:genetics*
D016207:Cytokines