title: Neuropsychological functioning in adolescent marijuana users: subtle deficits detectable after a month of abstinence.
abstract: In adults, studies examining the long-lasting cognitive effects of marijuana use demonstrate subtle deficits in attention, executive function, and memory. Because neuromaturation continues through adolescence, these results cannot necessarily generalize to adolescent marijuana users. The goal of this study was to examine neuropsychological functioning in abstinent marijuana using and demographically similar control adolescents. Data were collected from 65 adolescent marijuana users (n=31, 26% females) and controls (n=34, 26% females) 16-18 years of age. Extensive exclusionary criteria included independent psychiatric, medical, and neurologic disorders. Neuropsychological assessments were conducted after>23 days of monitored abstinence. After controlling for lifetime alcohol use and depressive symptoms, adolescent marijuana users demonstrated slower psychomotor speed (p<.05), and poorer complex attention (p<.04), story memory (p<.04), and planning and sequencing ability (p<.001) compared with controls. Post hoc analysis revealed that the number of lifetime marijuana use episodes was associated with poorer cognitive function, even after controlling for lifetime alcohol use. The general pattern of results suggested that, even after a month of monitored abstinence, adolescent marijuana users demonstrate subtle neuropsychological deficits compared with nonusers. It is possible that frequent marijuana use during adolescence may negatively influence neuromaturation and cognitive development.
authors: Department of Psychiatry, University of California, San Diego, and Psychology Department, VA San Diego Healthcare System, San Diego, California 92161, USA.
authors: Krista Lisdahl
authors: KL
authors: Medina
authors: Karen L
authors: KL
authors: Hanson
authors: Alecia D
authors: AD
authors: Schweinsburg
authors: Mairav
authors: M
authors: Cohen-Zion
authors: Bonnie J
authors: BJ
authors: Nagel
authors: Susan F
authors: SF
authors: Tapert
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000503:physiopathology*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011597:Psychomotor Performance / Q000502:physiology*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D011795:Surveys and Questionnaires
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