The identification of telomerase subunits: catalysing telomere research.
Telomerase is the ribonucleoprotein complex responsible for the addition of simple sequences onto the physical ends, or telomeres, of most eukaryotic chromosomes. The activity of this complex is essential for the maintenance of genome integrity. Recent studies have begun to dissect the mechanism of telomerase action through the identification of a reverse-transcriptase-like activity as a catalytic subunit. At the same time, the regulation of telomere length appears to be a complex and possibly species-specific process, involving factors that are likely to interact with both the telomere and telomerase.
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