title: Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zeta.
abstract: Little is known about the neuronal mechanisms that subserve long-term memory persistence in the brain. The components of the remodeled synaptic machinery, and how they sustain the new synaptic or cellwide configuration over time, are yet to be elucidated. In the rat cortex, long-term associative memories vanished rapidly after local application of an inhibitor of the protein kinase C isoform, protein kinase M zeta (PKMzeta). The effect was observed for at least several weeks after encoding and may be irreversible. In the neocortex, which is assumed to be the repository of multiple types of long-term memory, persistence of memory is thus dependent on ongoing activity of a protein kinase long after that memory is considered to have consolidated into a long-term stable form.
authors: Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
authors: Reut
authors: R
authors: Shema
authors: Todd Charlton
authors: TC
authors: Sacktor
authors: Yadin
authors: Y
authors: Dudai
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology*; D019579:Neocortex / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013649:Taste; D013997:Time Factors
chemical_list: D004791:Enzyme Inhibitors; D009842:Oligopeptides; D011493:Protein Kinase C; C504730:protein kinase M zeta, rat