title: Adaptive mutations in bacteria: high rate and small effects.
abstract: Evolution by natural selection is driven by the continuous generation of adaptive mutations. We measured the genomic mutation rate that generates beneficial mutations and their effects on fitness in Escherichia coli under conditions in which the effect of competition between lineages carrying different beneficial mutations is minimized. We found a rate on the order of 10(-5) per genome per generation, which is 1000 times as high as previous estimates, and a mean selective advantage of 1%. Such a high rate of adaptive evolution has implications for the evolution of antibiotic resistance and pathogenicity.
authors: Instituto Gulbenkian de Ciência, Rua da Quinta Grande, number 6, 2780-156 Oeiras, Portugal.
authors: Lília
authors: L
authors: Perfeito
authors: Lisete
authors: L
authors: Fernandes
authors: Catarina
authors: C
authors: Mota
authors: Isabel
authors: I
authors: Gordo
mesh_terms: D000220:Adaptation, Biological; D005075:Biological Evolution; D004926:Escherichia coli / Q000235:genetics* / Q000502:physiology; D016680:Genome, Bacterial; D018895:Microsatellite Repeats; D009154:Mutation; D012641:Selection, Genetic