Intrathecal baclofen therapy: indications, pharmacology, surgical implant, and efficacy.
Intrathecal baclofen (ITB) therapy is an option for those in whom predominantly lower extremity spasticity is severe, problematic, and intractable to oral doses of medications and/or focal treatment. When delivered to the lumbar area, ITB avoids high concentrations from reaching the brain (4:1 ratio lumbar to brain cisterns). A screening test dose is done prior to implanting the pump via a lumbar puncture with 50 microg baclofen, working up to 100 microg if necessary. There are two [2] types of pumps. The electronic programmable type has the advantage of flexibility of dosing and frequent change of doses for fine-tuning the patient's optimal dose. The mechanical constant flow type has the advantages of (1) being gas driven and not needing battery replacement, and (2) not needing a programmer to refill, thus allowing geographically removed patients to benefit from ITB. Catheter complications are reduced by using a shallow-angle paramedian oblique insertion to the spine, and meticulous anchoring of the catheter. Threading the catheter to T6/7 rather than the traditional T10/11 can allow upper limb relief also. Long term efficacy is excellent, although catheter complications are frequent. and if not recognized and treated, can lead to significant effects of withdrawal of baclofen.
Ethans
K
K
Section of Physical Medicine and Rehabilitation, University of Manitoba, Winnipeg, Manitoba, Canada. kethans@hsc.mb.ca
D001418:Baclofen / Q000494:pharmacology / Q000627:therapeutic use*; D002408:Catheters, Indwelling; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal / Q000379:methods; D009125:Muscle Relaxants, Central / Q000494:pharmacology / Q000627:therapeutic use*; D009128:Muscle Spasticity / Q000628:therapy*
D009125:Muscle Relaxants, Central; D001418:Baclofen