An animal model of functional electrical stimulation: evidence that the central nervous system modulates the consequences of training.
METHODS
Review of how spinal neurons can modulate the consequences of functional electrical stimulation (FES) in an animal model.


METHODS
Spinal effects of FES are examined in male Sprague-Dawley rats transected at the second thoracic vertebra. The rats are exposed to FES training 24-48 h after surgery. Experimental manipulations of stimulation parameters, combined with physiological and pharmacological procedures, are used to examine the potential role of spinal neurons.


RESULTS
The isolated spinal cord is inherently capable of learning the response-outcome relations imposed in FES training contingencies. Adaptive behavioral modifications are observed when an outcome (electrical stimulation) is contingent on a behavioral response. In contrast, a lack of correlation between the response and outcome in training produces a learning deficit in the spinal cord, rendering it incapable of adaptive learning for up to 48 h. The N-methyl-D-aspartic acid receptor appears to mediate both the adaptive plasticity and loss of plasticity, seen in this spinal model.


CONCLUSIONS
The behavioral effects observed with FES therapies are not simply due to the direct (motor) consequences of stimulation elicited by the activation of efferent motor neurons and/or selected muscles. FES training has the capacity to shape inherent spinal circuits and to produce a long-lasting behavioral modification. Further understanding of the spinal mechanisms underlying adaptive behavioral modification will be integral for establishing functional neural connections in a regenerating spinal system.
Hook
M A
MA
Department of Psychology, Texas A&M University, College Station, TX 77843-4235, USA.
Grau
J W
JW
D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004558:Electric Stimulation; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007858:Learning / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D023421:Models, Animal; D009474:Neurons / Q000187:drug effects / Q000528:radiation effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000166:cytology*; D013997:Time Factors
D000779:Anesthetics, Local; D018691:Excitatory Amino Acid Antagonists; D016291:Dizocilpine Maleate; D008012:Lidocaine
Arch Phys Med Rehabil. 2001 Jun;82(6):818-24
11387589
Annu Rev Biomed Eng. 2005;7:327-60
16004574
Ann N Y Acad Sci. 2001 Mar;933:142-56
12000017
Ann N Y Acad Sci. 2001 Mar;933:175-84
12000019
Phys Ther. 2002 Jul;82(7):707-15
12088467
Physiol Behav. 2002 Nov;77(2-3):259-67
12419402
J Neurophysiol. 2001 Aug;86(2):845-55
11495955
Scand J Rehabil Med. 2000 Jun;32(2):72-9
10853721
Behav Neurosci. 2002 Dec;116(6):1032-51
12492302
Behav Cogn Neurosci Rev. 2006 Dec;5(4):191-239
17099112
Neuroscience. 2006 Aug 11;141(1):421-31
16678969
Spinal Cord. 2006 Jun;44(6):357-61
16249784
J Neurosci. 2006 Feb 1;26(5):1562-70
16452679
Pain. 2006 Jan;120(1-2):182-7
16360266
Brain Res Brain Res Rev. 2002 Oct;40(1-3):202-14
12589918
Brain Res Brain Res Rev. 2002 Oct;40(1-3):257-66
12589924
Brain Res Brain Res Rev. 2002 Oct;40(1-3):274-91
12589926
Behav Brain Res. 2003 May 15;141(2):159-70
12742252
Behav Neurosci. 2003 Aug;117(4):799-812
12931964
Eur J Neurosci. 2003 Nov;18(9):2467-76
14622147
Ann N Y Acad Sci. 2003 Nov;1003:1-11
14684431
Neurobiol Learn Mem. 2004 Jul;82(1):35-51
15183169
Annu Rev Neurosci. 2004;27:145-67
15217329
Behav Brain Res. 2004 Oct 5;154(2):431-8
15313031
J Spinal Cord Med. 2004;27(4):365-75
15484667
J Neurosci. 1986 May;6(5):1433-42
3711988
J Neurophysiol. 1991 Dec;66(6):1874-87
1812222
J Neurotrauma. 1992 Summer;9(2):123-6; discussion 126-8
1404425
Exp Brain Res. 1992;90(3):469-78
1426107
Behav Neurosci. 1993 Jun;107(3):493-505
8392349
Behav Neurosci. 1994 Apr;108(2):235-40
7913606
J Neurosci. 1994 Sep;14(9):5580-9
7916046
Neuropeptides. 1994 Jun;26(6):413-9
7523981
Behav Neural Biol. 1994 Sep;62(2):140-50
7993304
J Neurotrauma. 1995 Feb;12(1):1-21
7783230
J Rehabil Res Dev. 1996 Apr;33(2):145-57
8724170
Behav Neurosci. 1996 Dec;110(6):1375-87
8986339
J Neurosci. 1997 Aug 15;17(16):6483-91
9236256
J Neurotrauma. 1997 Aug;14(8):517-37
9300563
Eur J Neurosci. 1998 Jul;10(7):2476-80
9749775
Behav Neurosci. 1998 Dec;112(6):1366-86
9926819
Arch Phys Med Rehabil. 1999 Feb;80(2):225-35
10025502
Clin Neurophysiol. 2005 Jan;116(1):75-86
15589186
J Neurotrauma. 2004 Nov;21(11):1601-13
15684652
J Neurotrauma. 2004 Dec;21(12):1795-817
15684770
Behav Neurosci. 2005 Apr;119(2):538-47
15839800
Nature. 2000 Jun 22;405(6789):955-9
10879537