Thrombophilia and antithrombotic therapy in women with recurrent spontaneous abortions.
OBJECTIVE
To investigate the association between thrombophilia and recurrent spontaneous abortions (RSAs) and to evaluate the efficacy of anticoagulant treatment.


METHODS
All couples with a history of RSAs were studied by immunologic tests and determination of coagulation factors. Low-molecular-weight heparin and low-dose aspirin daily during pregnancy were used in 29 selected cases with acquired and inherited thrombophilia. The control group included 23 women with a history of RSAs and tests positive for thrombophilia who declined to receive medication during pregnancy.


RESULTS
All couples with a history of RSAs were studied by immunologic tests and determination of coagulation factors. Low-molecular-weight heparin and low-dose aspirin daily during pregnancy were used in 29 selected cases with acquired and inherited thrombophilia. The control group included 23 women with a history of RSAs and tests positive for thrombophilia who declined to receive medication during pregnancy.


CONCLUSIONS
All couples with RSAs require screening for thrombophilia. Low-molecular-weight heparin and low-dose aspirin daily during pregnancy appear to have a favorable effect on pregnancy outcome in selected women with RSAs and acquired or inherited thrombophilia.
Deligiannidis
Aristidis
A
Immunology Department and National Peripheral Histocompatibility Center, Hippokration Hospital, Thessaloniki, Greece.
Parapanissiou
Efthimia
E
Mavridis
Panagiotis
P
Tabakoudis
George
G
Mavroudi
Antigoni
A
Papastavrou
Theodouli
T
Tabakoudis
Panagiotis
P
D000026:Abortion, Habitual / Q000188:drug therapy* / Q000209:etiology*; D000328:Adult; D001241:Aspirin / Q000627:therapeutic use*; D001779:Blood Coagulation Factors / Q000032:analysis; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006115:Greece; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D019851:Thrombophilia / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome
D001779:Blood Coagulation Factors; D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; D001241:Aspirin