Tumor necrosis factor alpha -308 polymorphism is associated with rheumatoid arthritis in Han population of Eastern China.
The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) in tumor necrosis factor alpha (TNFalpha) promoter with rheumatoid arthritis (RA) in Chinese Han population. Six SNPs at positions -238, -244, -308, -376, -857, -863 within TNFalpha promoter were genotyped in 367 unrelated RA patients and 271 healthy controls, using direct DNA sequencing method. Allelic, genotypic, and haplotypic associations of these SNPs with RA were examined. The frequencies of TNFalpha -308A allele and the haplotype GACC (in order of -238, -308, -857, -863) were significantly lower in RA patients when compared with healthy controls (P = 0.0046, P = 0.0045, respectively) but TNFalpha -308 polymorphism was not related to the clinical manifestations of RA patients. These results implied that TNFalpha gene itself or a gene in linkage disequilibrium with it might be associated with RA in Han population of Eastern China.
Chen
Ruiwen
R
Department of Medical Genetics, Second Military Medical University, Shanghai, People's Republic of China.
Fang
Meng
M
Cai
Qing
Q
Duan
Shiwei
S
Lv
Ke
K
Cheng
Ning
N
Ren
Daming
D
Shen
Jie
J
He
Dongyi
D
He
Lin
L
Sun
Shuhan
S
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005843:Geography; D006239:Haplotypes; D006801:Humans; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups / Q000235:genetics*; D011401:Promoter Regions, Genetic; D017422:Sequence Analysis, DNA; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha
Arthritis Rheum. 1991 Jul;34(7):822-30
2059230
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3195-9
9096369
EMBO J. 1991 Dec;10(13):4025-31
1721867
J Rheumatol. 2002 Jan;29(1):29-33
11824966
Genomics. 2001 Feb 1;71(3):263-70
11170743
Tissue Antigens. 1999 Aug;54(2):194-7
10488748
Scand J Immunol. 2006 Aug;64(2):164-9
16867162
Rheumatol Int. 2003 Jul;23(4):151-3
12750939
Tissue Antigens. 1998 Oct;52(4):359-67
9820599
Genet Epidemiol. 2003 Sep;25(2):115-21
12916020
Br Med Bull. 1995 Apr;51(2):267-85
7552063
N Engl J Med. 1997 Jul 17;337(3):141-7
9219699
Arthritis Rheum. 2006 Apr;54(4):1105-16
16572445
Arthritis Rheum. 2000 Jan;43(1):30-7
10643697
N Engl J Med. 1978 Apr 20;298(16):869-71
147420
Nat Genet. 1999 Jun;22(2):145-50
10369255
Ann Hum Genet. 1995 Jan;59(Pt 1):97-105
7762987
Dis Markers. 1995 Mar;12(2):127-33
7614782
Tissue Antigens. 1998 Jun;51(6):605-12
9694352
Br J Rheumatol. 1992 May;31(5):293-8
1581770
J Rheumatol. 2002 Feb;29(2):212-9
11838837
Hum Mol Genet. 1999 Aug;8(8):1443-9
10400991
Ann Rheum Dis. 2004 Mar;63(3):280-4
14962963
Rheumatology (Oxford). 2002 Jul;41(7):830-1
12096240
Hum Mol Genet. 2002 May 15;11(11):1281-9
12019209
Arthritis Rheum. 1993 Dec;36(12):1681-90
8250987
Eur J Immunogenet. 1999 Aug;26(4):249-55
10457886
Arthritis Rheum. 1988 Mar;31(3):315-24
3358796
J Rheumatol. 2001 Aug;28(8):1788-92
11508580
J Autoimmun. 2005 Feb;24(1):63-8
15725578
Ann Rheum Dis. 1999 Nov;58 Suppl 1:I70-2
10577977
Arthritis Rheum. 1988 Aug;31(8):1041-5
3136775
Clin Genet. 1989 Sep;36(3):178-82
2676268
J Rheumatol. 2003 Oct;30(10 ):2245-51
14528524
Immunogenetics. 1994;39(2):150-4
7903959
Br J Rheumatol. 1997 May;36(5):516-21
9189051
Genes Immun. 2001 Apr;2(2):82-7
11393661