title: Usefulness of drug eluting stent in percutaneous coronary intervention--a single center experience in Taiwan.
abstract: OBJECTIVE
  Drug eluting stents (DES) have been shown to reduce in-stent restenosis rate and target vessel revascularization in large clinical trials. However, the safety and efficacy of DES use in the Taiwanese population has not been reported. We designed this trial to analyze the clinical results in patients using DES in a single tertiary center.
  
  
  METHODS
  We retrospectively analyzed the clinical data of all patients treated at National Taiwan University Hospital, Taipei, Taiwan, with sirolimus- or paclitaxel-eluting stents between September 2003 and January 2005.
  
  
  RESULTS
  A total of 585 patients (466 men, 119 women; mean age, 64.5 +/- 11.2 years) were enrolled. Meanwhile, 205 sirolimus- and 717 paclitaxel-eluting stents were implanted, with a mean of 1.6 stents per patient. Half (50.2%) of the stents were placed in the left anterior descending artery. Among the enrolled patients, 41.8% had diabetes mellitus, 25% had a diagnosis of acute coronary syndrome, and 10.7% was treated with primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Overall 8-month target vessel revascularization, major adverse cardiac event rate, and cardiac death rate were 8.8%, 9.7% and 2.5%, respectively. There was no difference in clinical events between sirolimus- and paclitaxel-eluting stents. The overall subacute stent thrombosis rate was 1.36%, significantly lower than that in patients who presented with acute coronary syndrome (4%).
  
  
  CONCLUSIONS
  The use of DES in the Taiwanese population yielded comparable results as those in large clinical trials. Subacute stent thrombosis rate was higher in acute coronary syndrome. The safety of DES in these situations should be further clarified.
authors: Cardiovascular Division, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors: Juey-Jen
authors: JJ
authors: Hwang
authors: Chih-Neng
authors: CN
authors: Hsu
authors: Chi-Sheng
authors: CS
authors: Hung
authors: Yen-Hung
authors: YH
authors: Lin
authors: Hsien-Li
authors: HL
authors: Kao
authors: Fu-Tien
authors: FT
authors: Chiang
authors: Chia-Lun
authors: CL
authors: Chao
authors: Chii-Ming
authors: CM
authors: Lee
authors: Tzung-Dau
authors: TD
authors: Wang
authors: Chiau-Suong
authors: CS
authors: Liau
authors: Kwan-Lih
authors: KL
authors: Hsu
authors: Lung-Chun
authors: LC
authors: Lin
authors: Chia-Ti
authors: CT
authors: Tsai
authors: Chuen-Den
authors: CD
authors: Tseng
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D012189:Retrospective Studies; D020123:Sirolimus / Q000008:administration & dosage; D015607:Stents; D013624:Taiwan; D016896:Treatment Outcome
chemical_list: D017239:Paclitaxel; D020123:Sirolimus