Recovery from cisplatin-induced ototoxicity: a case report and review.
We present a pediatric case report of cisplatin-induced ototoxicity with subsequent recovery. The patient experienced tinnitus and fluctuating mild high-frequency sensorineural hearing loss (SNHL) with a concomitant decrease in distortion product otoacoustic emissions (DPOAE). There was recovery of hearing loss and return of DPOAE at 1 year after completion of cisplatin therapy. Reports of recovery from cisplatin-induced ototoxicity in humans are limited in the literature, especially in the pediatric population. A review of cisplatin ototoxicity and mechanisms of recovery are discussed, with an emphasis on the particular chemotherapy regimen and dosing schedule in this case, given at 4-11 week intervals.
Truong
Mai Thy
MT
Lucile Packard Children's Hospital, USA. mttruong@stanford.edu
Winzelberg
Jody
J
Chang
Kay W
KW
D000161:Acoustic Stimulation; D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy*; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D003051:Cochlea / Q000187:drug effects / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D006811:Humerus / Q000473:pathology*; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy*; D020127:Recovery of Function; D012720:Severity of Illness Index; D014012:Tinnitus / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology
D000970:Antineoplastic Agents; D002945:Cisplatin