title: The influence of dinoprostone on uterine cervix ripening and the course of labor.
abstract: OBJECTIVE
  The aim of the study was to estimate the influence of dinoprostone in two different forms on the ripening of uterine cervix and the course of labor.
  
  
  METHODS
  128 pregnant women with indications for labor induction and uterine cervix Bishop's scores <6, divided into 2 groups: I--62 patients who had dinoprostone in the form of a gel applied for labor preinduction; II--66 women who were administered dinoprostone in the form of vaginal inserts. The effectiveness of both forms of dinoprostone were estimated and compared.
  
  
  RESULTS
  No differences in Bishop's score changes were noticeable between the groups after 6-8 hours from application, however they were significant at the beginning of induction: I - 7.8+/-1.3 vs. II - 6.9+/-1.6 (p=0.0007). Almost half of the patients from group II had spontaneous contractions and required no labor induction at all. The average time from dinoprostone application till delivery was shorter in group II.
  
  
  CONCLUSIONS
  Dinoprostone vaginal inserts seem to influence both uterine cervix and muscle, while gel-prepare uterine cervix for delivery more effectively.
authors: 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Plac Starynkiewicza 1/3, 02-015 Warsaw, Poland. mwielgos@amwaw.edu.pl
authors: Miroslaw
authors: M
authors: Wielgos
authors: Iwona
authors: I
authors: Szymusik
authors: Katarzyna
authors: K
authors: Kosinska-Kaczynska
authors: Barbara
authors: B
authors: Suchonska
authors: Pawel
authors: P
authors: Kaminski
authors: Agnieszka
authors: A
authors: Banaszek-Wysoczanska
authors: Dorota
authors: D
authors: Bomba-Opon
authors: Monika
authors: M
authors: Szpotanska
mesh_terms: D002584:Cervix Uteri / Q000187:drug effects / Q000502:physiology*; D017364:Collagenases / Q000378:metabolism; D015232:Dinoprostone / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009215:Myometrium / Q000187:drug effects / Q000502:physiology; D010120:Oxytocics / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011509:Proteoglycans / Q000378:metabolism; D013488:Suppositories; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects / Q000502:physiology; D014622:Vaginal Creams, Foams, and Jellies
chemical_list: D010120:Oxytocics; D011509:Proteoglycans; D013488:Suppositories; D014622:Vaginal Creams, Foams, and Jellies; D017364:Collagenases; D015232:Dinoprostone