Typing of the immunological system in human embryos by coelocentesis.
Coelocentesis offers a new opportunity for gaining access to the human embryos from 28 d postfertilization. However, while some studies about its biochemical composition have been reported, our knowledge about immunological pattern of this compartment is still limited. For this reason, we studied the human coelomic fluids sampled from 6.6 to 10 wk of gestation. The majority of cellular population consisted in mesenchymal/epithelial cells. In fluids sampled before 10 wk we found only a preT Cell Receptor expression and an absence or a very low frequency of B lymphocytes, T lymphocytes and NK (natural killer) antigens. These preliminary data suggest that the immunological system in human embryos could be in the ideal conditions to start a process of tolerance induction.
Renda
Maria Concetta
MC
Regional Center for Thalassemia, Haematology II with Thalassemia, V. Cervello Hospital, Palermo, Italy.
Makrydimas
George
G
Nicolaides
Kipros H
KH
Fecarotta
Emanuela
E
Damiani
Gianfranca
G
Picciotto
Francesco
F
Jakil
Maria Cristina
MC
Maggio
Aurelio
A
D000649:Amniocentesis; D000653:Amniotic Fluid / Q000276:immunology*; D004622:Embryo, Mammalian / Q000276:immunology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy