Quantitative analysis of nasal vascularization in allergic patients treated with mometasone furoate.
The purpose of this study was to compare vascularization of the nasal mucous membrane among non-allergic, non-treated allergic and allergic patients treated with mometasone furoate, by means of the stereology method in quantitative analysis. Three groups of patients (GP), each containing 10 patients were examined. The first group (GP 1) had a negative inhalatory allergen test while the second (GP 2) and third (GP 3) group both had positive results with the same test. GP 3 included allergic patients treated with mometasone furoate for 15 days before analysis, when a small piece of the nasal mucous membrane was taken from the frontal pole of the lower nasal shell. The specimens were examined immunohistochemically for expression of CD31 and VEGF-C. Vascular phase was determined by using length density (L(v)). Differences in CD31 and VEGF-C expression were compared using one-way ANOVA and Tukey HSD post-hoc tests. CD31 expression in GP 1 had significantly lower values than in the GP 2 and GP 3 groups (p < 0.001). VEGF-C expression in GP 1 was significantly lower than in GP 2 (p = 0.007), but not in GP 3 (p = 0.292). We have shown that 15-day treatment with mometasone furoate results in a significant reduction of the density of vascular elements in allergic patients.
Kujundzić
Milodar
M
Department of Otorhinolaryngology, School of Medicine, University of Rijeka, Rijeka, Croatia.
Cvjetković
Niko
N
Batinac
Tanja
T
Hadzisejdić
Ita
I
Zamolo
Gordana
G
Velepic
Marko
M
Brumini
Gordana
G
Brusić
Sandro
S
D000293:Adolescent; D000328:Adult; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000068656:Mometasone Furoate; D009389:Neovascularization, Pathologic; D009666:Nose / Q000098:blood supply*; D011244:Pregnadienediols / Q000627:therapeutic use*
D018926:Anti-Allergic Agents; D011244:Pregnadienediols; D000068656:Mometasone Furoate