title: Factors associated with epilepsy in children with periventricular leukomalacia.
abstract: Children with cerebral palsy associated with periventricular leukomalacia frequently develop unprovoked epileptic seizures. This article reports an analysis of risk factors for epilepsy in children with radiologically confirmed periventricular leukomalacia. This cohort was screened for epilepsy and for an array of clinical and demographic factors. Of 154 subjects with radiologically confirmed periventricular leukomalacia, 40 (26.0%) had epilepsy. In the epileptic group, radiologic pathology other than periventricular leukomalacia was uncommon. Significant associations were found between epilepsy and cerebral palsy patterns other than spastic diparesis, mental handicap, cortical visual impairment, neonatal seizures, and severe periventricular leukomalacia. Only the presence of neonatal seizures was significantly associated with epilepsy once other risk factors were controlled in the regression model. Some previous studies have shown an association between neonatal seizures and later epilepsy for cerebral palsy in general. This is the first report of such an association for a single predominant type of cerebral pathology.
authors: Division of Neurology, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa Children's Treatment Centre Ottawa, Ontario, Canada. phumphreys@cheo.on.ca
authors: Peter
authors: P
authors: Humphreys
authors: Raywat
authors: R
authors: Deonandan
authors: Sharon
authors: S
authors: Whiting
authors: Nick
authors: N
authors: Barrowman
authors: Mary-Ann
authors: MA
authors: Matzinger
authors: Valerie
authors: V
authors: Briggs
authors: Julie
authors: J
authors: Hurteau
authors: Eda
authors: E
authors: Wallace
mesh_terms: D002547:Cerebral Palsy / Q000209:etiology; D002675:Child, Preschool; D015331:Cohort Studies; D004827:Epilepsy / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007969:Leukomalacia, Periventricular / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000379:methods