A new cytotoxic cholesterol sulfate from marine sponge Halichondria rugosa.
A new steroid, 24xi,25-dimethyl-3alpha-hydroxyl-cholest-5-ene-2beta-ol sodium sulfate (1), together with a known steroid, 24xi,25-dimethyl-cholest-5-ene-2beta,3alpha-diol disodium sulfate (2), was isolated from the ethanol extract of marine sponge Halichondria rugosa. Their structures were elucidated on the base of spectroscopic analysis. Both compounds showed cytotoxicity to four human cancer cell lines (BEL-7402, HT-29, SPC-A1 and U-251) with IC(50) values between 6.5 and 23.1 microM.
Zhang
Hong-Jun
HJ
Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200433, China.
Sun
Jing-Bo
JB
Lin
Hou-Wen
HW
Wang
Zeng-Lei
ZL
Tang
Hua
H
Cheng
Ping
P
Chen
Wan-Sheng
WS
Yi
Yang-Hua
YH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002788:Cholesterol Esters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera
C523932:24xi,25-dimethyl-3alpha-hydroxyl-cholest-5-ene-2beta-ol; D000970:Antineoplastic Agents; D002788:Cholesterol Esters; C007045:cholesteryl sulfate