title: Synthesis, characterization, and hydrolytic degradation behavior of a novel biodegradable pH-sensitive hydrogel based on polycaprolactone, methacrylic acid, and poly(ethylene glycol).
abstract: In this work, a new kind of biodegradable pH-sensitive hydrogel was successfully synthesized by UV-initiated free radical polymerization. The obtained hydrogel was characterized by (1)H NMR and FTIR. Swelling behavior in different aqueous media and pH responsivity of the hydrogels were studied in detail as well. With increase in pH from 1.2 to 7.2, swelling ratio of the hydrogel increased. The morphology was observed by scanning electron microscopy, and the hydrolytic degradation behavior was also investigated in this work.
authors: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
authors: Guo Tao
authors: GT
authors: Chao
authors: Zhi Yong
authors: ZY
authors: Qian
authors: Mei Juan
authors: MJ
authors: Huang
authors: Bing
authors: B
authors: Kan
authors: Ying Chun
authors: YC
authors: Gu
authors: Chang Yang
authors: CY
authors: Gong
authors: Jin Liang
authors: JL
authors: Yang
authors: Ke
authors: K
authors: Wang
authors: Mei
authors: M
authors: Dai
authors: Xing Yi
authors: XY
authors: Li
authors: Ma Ling
authors: ML
authors: Gou
authors: Ming Jing
authors: MJ
authors: Tu
authors: Yu Quan
authors: YQ
authors: Wei
mesh_terms: D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010777:Photochemistry; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D020100:Hydrogels; D008689:Methacrylates; D011091:Polyesters; C008384:methacrylic acid; C016240:polycaprolactone; D011092:Polyethylene Glycols