title: Pathogenesis-related adhesion molecules in Henoch-Schonlein vasculitis.
abstract: The aim of this study was to reveal the distribution of various inflammation and endothelium-related adhesion molecules, namely, P-selectin, E-selectin, ICAM-1, ICAM-2, ICAM-3 and VCAM-1, on the skin samples of patients with Henoch-Schonlein purpura. Skin biopsies obtained from 12 pediatric patients at the acute purpura phase and from 5 patients at the convalescent phase of the disease were included in the study. Endothelial expression of P-selectin (P < 0.05), endothelial and inflammatory cellular expressions of ICAM-2 (P < 0.05, P < 0.01) and inflammatory cellular expression of ICAM-3 (P < 0.05) were significantly more intense when compared to patients in the convalescent phase. Although endothelial E-selectin and VCAM-1 expressions, and endothelial and inflammatory cellular ICAM-1 expressions displayed a decrease in the convalesant phase, this difference was not found to be statistically significant (P > 0.05).
authors: Department of Pediatric Nephrology, Gulhane Military Medical Academy, School of Medicine, 06018, Etlik, Ankara, Turkey. faysalgok@yahoo.com
authors: Faysal
authors: F
authors: Gok
authors: Yesim
authors: Y
authors: Ugur
authors: Seza
authors: S
authors: Ozen
authors: Attila
authors: A
authors: Dagdeviren
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis*; D002648:Child; D019040:E-Selectin / Q000032:analysis; D042783:Endothelial Cells / Q000276:immunology; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology* / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D008297:Male; D019007:P-Selectin / Q000032:analysis; D011446:Prospective Studies; D012867:Skin / Q000276:immunology* / Q000473:pathology; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis
chemical_list: D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D019040:E-Selectin; C065289:ICAM2 protein, human; C483616:ICAM3 protein, human; D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1
references: Clin Exp Immunol. 1997 Jun;108(3):446-50
references: 9182890
references: Pediatr Clin North Am. 1995 Oct;42(5):1239-61
references: 7567194
references: Clin Sci (Lond). 1991 Oct;81(4):477-81
references: 1682080
references: Arch Dis Child. 1996 Dec;75(6):507-11
references: 9014604
references: Nephron. 1999;81(3):256-63
references: 10050078
references: Arthritis Rheum. 1994 Feb;37(2):187-92
references: 8129773
references: Arch Dis Child. 1999 Apr;80(4):380-3
references: 10086951
references: J Am Soc Nephrol. 1999 Dec;10(12):2637-44
references: 10589705
references: Lab Invest. 1993 Sep;69(3):329-35
references: 7690868
references: Arch Dermatol. 1997 Apr;133(4):443-50
references: 9126007
references: Ann Rheum Dis. 2006 Jul;65(7):936-41
references: 16322081
references: Arthritis Rheum. 1990 Aug;33(8):1114-21
references: 2202310
references: Ann Rheum Dis. 1997 Jan;56(1):41-4
references: 9059140
references: Arthritis Rheum. 1998 Mar;41(3):435-44
references: 9506571