title: Thrombophilia and antithrombotic therapy in women with recurrent spontaneous abortions.
abstract: OBJECTIVE
  To investigate the association between thrombophilia and recurrent spontaneous abortions (RSAs) and to evaluate the efficacy of anticoagulant treatment.
  
  
  METHODS
  All couples with a history of RSAs were studied by immunologic tests and determination of coagulation factors. Low-molecular-weight heparin and low-dose aspirin daily during pregnancy were used in 29 selected cases with acquired and inherited thrombophilia. The control group included 23 women with a history of RSAs and tests positive for thrombophilia who declined to receive medication during pregnancy.
  
  
  RESULTS
  All couples with a history of RSAs were studied by immunologic tests and determination of coagulation factors. Low-molecular-weight heparin and low-dose aspirin daily during pregnancy were used in 29 selected cases with acquired and inherited thrombophilia. The control group included 23 women with a history of RSAs and tests positive for thrombophilia who declined to receive medication during pregnancy.
  
  
  CONCLUSIONS
  All couples with RSAs require screening for thrombophilia. Low-molecular-weight heparin and low-dose aspirin daily during pregnancy appear to have a favorable effect on pregnancy outcome in selected women with RSAs and acquired or inherited thrombophilia.
authors: Immunology Department and National Peripheral Histocompatibility Center, Hippokration Hospital, Thessaloniki, Greece.
authors: Aristidis
authors: A
authors: Deligiannidis
authors: Efthimia
authors: E
authors: Parapanissiou
authors: Panagiotis
authors: P
authors: Mavridis
authors: George
authors: G
authors: Tabakoudis
authors: Antigoni
authors: A
authors: Mavroudi
authors: Theodouli
authors: T
authors: Papastavrou
authors: Panagiotis
authors: P
authors: Tabakoudis
mesh_terms: D000026:Abortion, Habitual / Q000188:drug therapy* / Q000209:etiology*; D000328:Adult; D001241:Aspirin / Q000627:therapeutic use*; D001779:Blood Coagulation Factors / Q000032:analysis; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006115:Greece; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D019851:Thrombophilia / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D001779:Blood Coagulation Factors; D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; D001241:Aspirin