Accuracy of N-terminal pro-brain natriuretic peptide to predict mortality in various subsets of patients with coronary artery disease.
The ability of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) to predict mortality in various subsets of patients with coronary artery disease (CAD) is not known. The aim of present study was to investigate the ability of NT-pro-BNP to predict mortality in various subsets of patients with CAD. The study included 1,552 consecutive patients with angiographically proven CAD. Based on receiver-operating characteristic curve analysis, the best NT-pro-BNP level for mortality prediction was 721 ng/L (sensitivity 71.3%, specificity 71.3%). Patients were divided into 2 groups: the group with NT-pro-BNP level < or =721 ng/L (1,034 patients) and the group with NT-pro-BNP level >721 ng/L (518 patients). The primary end point of the study was mortality. The median follow-up was 3.6 years (interquartile range 3.3 to 4.6). In total there were 171 deaths: 49 deaths in the group with NT-pro-BNP < or =721 ng/L and 122 deaths in the group with NT-pro-BNP >721 ng/L (mortality estimates 6.6% vs 29.5%, odds ratio 5.2; 95% confidence intervals 3.9 to 7.0, p <0.001). In 28 subsets of patients, NT-pro-BNP level predicted mortality with odds ratio varying from 2.8 to 7.5. In conclusion, NT-pro-BNP is a reliable predictive marker of mortality in all subsets of patients with CAD.
Ndrepepa
Gjin
G
Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Munich, Germany. ndrepepa@dhm.mhn.de
Braun
Siegmund
S
Schömig
Albert
A
Kastrati
Adnan
A
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis / Q000382:microbiology; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009391:Nephelometry and Turbidimetry; D016017:Odds Ratio; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D011498:Protein Precursors; D012372:ROC Curve; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors
D015415:Biomarkers; D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain