A novel approach to clinical-radiological correlations: Anatomo-Clinical Overlapping Maps (AnaCOM): method and validation.
We present a new clinical-radiological correlation method (AnaCOM) that aims at establishing structure-function relationships. We validated AnaCOM by assessing the location of lesions that are associated with altered performances in a well-studied task: the verbal fluency task. We retrospectively reviewed 64 brain-damaged patients who had focal lesions in a variety of cortical sites due to stroke, hemorrhage or tumor surgery. All patients were tested for verbal fluency at the time of the MRI examination. MRI volumes were normalized using a mask covering brain lesions and artifacts. The brain lesions were then segmented using the normalized MRI. In each patient, a verbal fluency score was assigned to each voxel in the segmented area. Subsequently, segmentations were superimposed and voxels were gathered in clusters defined by the overlap of the patients' lesion. For each cluster, the scores were statistically compared to those obtained by controls for the same task. This process allowed the construction of cluster-by-cluster statistical maps of anatomo-clinical correlations. As expected, the statistical map indicated that two regions were significantly associated with a deficit in the fluency task: one located in Broca's area and the other in the preSMA. AnaCOM does not require a priori selection of the location of lesions or task scores. The method complements the functional imaging techniques, as it tells which regions are necessary for a given function and it explores cortical regions as well as the white matter.
Kinkingnéhun
Serge
S
INSERM U610, Paris, France. serge@skinkin.com
Volle
Emmanuelle
E
Pélégrini-Issac
Mélanie
M
Golmard
Jean-Louis
JL
Lehéricy
Stéphane
S
du Boisguéheneuc
Foucaud
F
Zhang-Nunes
Sandy
S
Sosson
Danielle
D
Duffau
Hugues
H
Samson
Yves
Y
Levy
Richard
R
Dubois
Bruno
B
D000465:Algorithms; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D001927:Brain Diseases / Q000473:pathology* / Q000503:physiopathology*; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data; D020300:Intracranial Hemorrhages / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology; D011183:Postoperative Complications / Q000473:pathology / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology; D015203:Reproducibility of Results; D020521:Stroke / Q000473:pathology / Q000503:physiopathology; D014705:Verbal Behavior / Q000502:physiology*