Effect of orphanin FQ/nociceptin (OFQ/N) and isoflurane on the prolactin secretory response in OFQ/N knockout mice.
The prolactin secretory response to subcutaneous injection of orphanin FQ/nociceptin (OFQ/N) was measured in wild-type and OFQ/N knockout mice. These injections were given with and without isoflurane anesthesia, to determine if isoflurane would affect the prolactin secretory response. OFQ/N injection significantly increased prolactin levels in males and females, regardless of genotype, with a more robust response in females. Isoflurane pretreatment did not affect prolactin levels in controls or in animals injected with OFQ/N. This is the first report that exogenously administered OFQ/N stimulates prolactin secretion in mice and that brief isoflurane exposure does not significantly affect this response.
Zullig
Kelly L
KL
Center for Neuroscience, Department of Zoology, 212 Pearson Hall, Miami University, Oxford, OH 45056, USA.
Murphree
Emily
E
Reinscheid
Rainer K
RK
Janik
James
J
Callahan
Phyllis
P
D018685:Anesthetics, Inhalation / Q000494:pharmacology; D000818:Animals; D005260:Female; D007279:Injections, Subcutaneous; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018847:Opioid Peptides / Q000008:administration & dosage / Q000172:deficiency* / Q000235:genetics / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D000097629:Nociceptin
D018685:Anesthetics, Inhalation; D007530:Isoflurane; D018847:Opioid Peptides; D011388:Prolactin; D000097629:Nociceptin
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