title: Fetal to adult stem cell transition: knocking Sox17 off.
abstract: What controls the inherent differences between fetal and adult hematopoietic stem cells (HSCs)? In this issue of Cell, Kim et al. (2007) demonstrate in mice that the endodermal transcription factor Sox17 is required for the maintenance of fetal and neonatal but not adult HSCs.
authors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. yjang3@jhmi.edu
authors: Yoon-Young
authors: YY
authors: Jang
authors: Saul J
authors: SJ
authors: Sharkis
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology* / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D053686:Fetal Stem Cells / Q000166:cytology* / Q000378:metabolism*; D024002:HMGB Proteins / Q000172:deficiency* / Q000235:genetics* / Q000502:physiology; D051379:Mice; D055760:SOXF Transcription Factors; D014157:Transcription Factors / Q000172:deficiency* / Q000235:genetics* / Q000502:physiology
chemical_list: D024002:HMGB Proteins; D055760:SOXF Transcription Factors; C511606:Sox17 protein, mouse; D014157:Transcription Factors