Enantioselective benzoylation of alpha-amino esters using (S)-1-benzoyl-2- (alpha-acetoxyethyl)benzimidazole, a chiral benzimidazolide.
A new chiral benzimidazolide is developed as a nonenzymatic acylating agent for enantioselective benzoylation of racemic alpha-amino esters. The process is highly efficient, which exhibits uniformly high enantioselectivity for alpha-amino esters with or without aryl substituents under mild reaction conditions. The chiral benzimidazolide is inexpensive and is easily accessible.
Karnik
Anil V
AV
Department of Chemistry, University of Mumbai, Vidyanagari, Santacruz (E), Mumbai 400098, India. avkarnik@chem.mu.ac.in
Kamath
Suchitra S
SS
D000215:Acylation; D000596:Amino Acids / Q000737:chemistry*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D001562:Benzimidazoles; D004952:Esters