Combined treatments for major depression.
Major depression is a chronic disorder with a high morbidity and mortality. Approved treatment for major depression at present includes monotherapy with antidepressants of different pharmacologic classes. There is increasingly widespread use of two other options: augmentation, the addition to an antidepressant of a second compound that is not an antidepressant when used alone; and combination, which is the use of two antidepressants concurrently to enhance or accelerate response. This review focuses on the data available to support these various augmentation and combination treatments.
Joffe
Russell T
RT
New Jersey Medical School, Department of Psychiatry, Maplewood, NJ 07040, USA. Rjoffe51@verizon.net
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology*; D004359:Drug Therapy, Combination; D006801:Humans; D014179:Neurotransmitter Uptake Inhibitors / Q000008:administration & dosage
D000928:Antidepressive Agents; D014179:Neurotransmitter Uptake Inhibitors