Pathogenesis-related adhesion molecules in Henoch-Schonlein vasculitis.
The aim of this study was to reveal the distribution of various inflammation and endothelium-related adhesion molecules, namely, P-selectin, E-selectin, ICAM-1, ICAM-2, ICAM-3 and VCAM-1, on the skin samples of patients with Henoch-Schonlein purpura. Skin biopsies obtained from 12 pediatric patients at the acute purpura phase and from 5 patients at the convalescent phase of the disease were included in the study. Endothelial expression of P-selectin (P < 0.05), endothelial and inflammatory cellular expressions of ICAM-2 (P < 0.05, P < 0.01) and inflammatory cellular expression of ICAM-3 (P < 0.05) were significantly more intense when compared to patients in the convalescent phase. Although endothelial E-selectin and VCAM-1 expressions, and endothelial and inflammatory cellular ICAM-1 expressions displayed a decrease in the convalesant phase, this difference was not found to be statistically significant (P > 0.05).
Gok
Faysal
F
Department of Pediatric Nephrology, Gulhane Military Medical Academy, School of Medicine, 06018, Etlik, Ankara, Turkey. faysalgok@yahoo.com
Ugur
Yesim
Y
Ozen
Seza
S
Dagdeviren
Attila
A
D015703:Antigens, CD / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis*; D002648:Child; D019040:E-Selectin / Q000032:analysis; D042783:Endothelial Cells / Q000276:immunology; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology* / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D008297:Male; D019007:P-Selectin / Q000032:analysis; D011446:Prospective Studies; D012867:Skin / Q000276:immunology* / Q000473:pathology; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D019040:E-Selectin; C065289:ICAM2 protein, human; C483616:ICAM3 protein, human; D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1
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