title: A multidimensional analysis of genes mutated in breast and colorectal cancers.
abstract: A recent study of a large number of genes in a panel of breast and colorectal cancers identified somatic mutations in 1149 genes. To identify potential biological processes affected by these genes, we examined their putative roles based on sequence similarity, membership in known functional groups and pathways, and predicted interactions with other proteins. These analyses identified functional groups and pathways that were enriched for mutated genes in both tumor types. Additionally, the results pointed to differences in molecular mechanisms that underlie breast and colorectal cancers, including various intracellular signaling and metabolic pathways. These studies provide a multidimensional framework to guide further research and help identify cellular processes critical for malignant progression and therapeutic intervention.
authors: Ludwig Center for Cancer Genetics and Therapeutics, and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA.
authors: Jimmy
authors: J
authors: Lin
authors: Christine M
authors: CM
authors: Gan
authors: Xiaosong
authors: X
authors: Zhang
authors: Siân
authors: S
authors: Jones
authors: Tobias
authors: T
authors: Sjöblom
authors: Laura D
authors: LD
authors: Wood
authors: D Williams
authors: DW
authors: Parsons
authors: Nickolas
authors: N
authors: Papadopoulos
authors: Kenneth W
authors: KW
authors: Kinzler
authors: Bert
authors: B
authors: Vogelstein
authors: Giovanni
authors: G
authors: Parmigiani
authors: Victor E
authors: VE
authors: Velculescu
mesh_terms: D000595:Amino Acid Sequence; D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D016000:Cluster Analysis; D015179:Colorectal Neoplasms / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D009154:Mutation; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid
chemical_list: D009363:Neoplasm Proteins
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