[The experimental study on biodegradable gel membrane applied to prevention of postoperative adhesion of abdominal cavity surgery].
OBJECTIVE
To develop a new type of anti-adhesion gel membrane and explore its applying technique.


METHODS
24 adult New Zealand white rabbits were used for the experiment research project, the animals were divided into two groups: the experiment group (18 adult New Zealand white rabbits) and the control group (6 adult New Zealand white rabbits). The animal models were established via the abdominal cavity. The biodegradable gel membrane was covered to the surface of the operating region in experimental animal group, while the 0.9% NaCL was directly rinsing the operating region in the controlled group. The specimens were collected at postoperatively week 2, 4 or 8 respectively. The samples were evaluated by global and histological observation.


RESULTS
In the experiment group, a few adhed zones were observed in 2 and 4 weeks after operation, but in 8 weeks after operation, the adhesion zone was disappeared. In the control group, a few adheol zones were founded in 2 weeks after operation. In 4 weeks after operation, the adhed zone become conspicuously emerged. In 8 weeks after operation, the cicatri band was occurred.


CONCLUSIONS
The biodegradable gel membrane usd into the postoperative abdominal cavity is effective and easy to manipulate, and it could be used as a high-effect, cheap drug of anti-adhesion in operation for surgeons.
Song
Ju-kun
JK
Key Lab. of Biomedical Engineering, Sichuan University, Chengdu 610041, China.
Bao
Chong-yun
CY
Yuan
Ming-long
ML
Ding
Yun-ping
YP
Zhou
Jing-lin
JL
Xue
Jing
J
Jiang
Hua-zhou
HZ
Liao
Yun-mao
YM
Li
Wei
W
D034841:Abdominal Cavity / Q000473:pathology* / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D005260:Female; D005782:Gels; D008297:Male; D008567:Membranes, Artificial; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D013997:Time Factors; D000267:Tissue Adhesions / Q000517:prevention & control
D001672:Biocompatible Materials; D005782:Gels; D008567:Membranes, Artificial