title: A message emerging from development: the repression of mitochondrial beta-F1-ATPase expression in cancer.
abstract: Mitochondrial research has experienced a considerable boost during the last decade because organelle malfunctioning is in the genesis and/or progression of a vast array of human pathologies including cancer. The renaissance of mitochondria in the cancer field has been promoted by two main facts: (1) the molecular and functional integration of mitochondrial bioenergetics with the execution of cell death and (2) the implementation of (18)FDG-PET for imaging and staging of tumors in clinical practice. The latter, represents the bed-side translational development of the metabolic hallmark that describes the bioenergetic phenotype of most cancer cells as originally predicted at the beginning of previous century by Otto Warburg. In this minireview we will briefly summarize how the study of energy metabolism during liver development forced our encounter with Warburg's postulates and prompted us to study the mechanisms that regulate the biogenesis of mitochondria in the cancer cell.
authors: Departamento de Biología Molecular, Centro de Biología Molecular "Severo Ochoa", Centro de Investigación Biomédica en Red de Enfermedades Raras, Universidad Autónoma de Madrid, 28049. Madrid, Spain. jmcuezva@cbm.uam.es
authors: José M
authors: JM
authors: Cuezva
authors: María
authors: M
authors: Sánchez-Aragó
authors: Sandra
authors: S
authors: Sala
authors: Amaya
authors: A
authors: Blanco-Rivero
authors: Alvaro D
authors: AD
authors: Ortega
mesh_terms: D000818:Animals; D006019:Glycolysis; D006801:Humans; D008099:Liver / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D008930:Mitochondria, Liver / Q000201:enzymology*; D009369:Neoplasms / Q000201:enzymology*; D010085:Oxidative Phosphorylation; D020543:Proteome / Q000378:metabolism; D006180:Proton-Translocating ATPases / Q000096:biosynthesis*
chemical_list: D020543:Proteome; D006180:Proton-Translocating ATPases
references: Cancer Res. 1999 Nov 1;59(21):5403-7
references: 10554005
references: Eur J Biochem. 1995 Sep 1;232(2):344-50
references: 7556180
references: Science. 1956 Feb 24;123(3191):309-14
references: 13298683
references: Science. 1956 Aug 10;124(3215):269-70
references: 13351639
references: Oncogene. 2004 Apr 12;23(16):2746-56
references: 15077138
references: Oncogene. 2002 May 9;21(20):3139-48
references: 12082629
references: Proteomics. 2004 Jan;4(1):271-8
references: 14730689
references: Cancer Res. 2002 Feb 15;62(4):972-6
references: 11861366
references: Annu Rev Genet. 2005;39:503-36
references: 16285870
references: Nat Cell Biol. 2000 Jun;2(6):318-25
references: 10854321
references: Biol Neonate. 1985;48(4):185-96
references: 2998491
references: Mol Cell Biol. 2000 May;20(10):3590-6
references: 10779348
references: Mol Cancer. 2002 Dec 09;1:9
references: 12513701
references: Biochem J. 1997 Mar 1;322 ( Pt 2):557-65
references: 9065777
references: Carcinogenesis. 2005 Dec;26(12):2095-104
references: 16033770
references: Biochem Biophys Res Commun. 1995 Dec 26;217(3):1094-8
references: 8554562
references: RNA. 1998 Dec;4(12):1500-13
references: 9848649
references: Biochem J. 2000 Mar 15;346 Pt 3:849-55
references: 10698716
references: Cancer Res. 2002 Nov 15;62(22):6674-81
references: 12438266
references: Cell Metab. 2006 Mar;3(3):177-85
references: 16517405
references: Annu Rev Genet. 2005;39:359-407
references: 16285865
references: J Biol Chem. 2000 Mar 10;275(10):7430-7
references: 10702318
references: J Biol Chem. 2004 Feb 27;279(9):7512-20
references: 14660625
references: Science. 2006 May 26;312(5777):1158-9
references: 16728625
references: Carcinogenesis. 2004 Jul;25(7):1157-63
references: 14963017
references: Cancer Res. 2005 Apr 15;65(8):3162-70
references: 15833846
references: J Bioenerg Biomembr. 1997 Aug;29(4):365-77
references: 9387097
references: J Natl Cancer Inst. 2006 Oct 18;98(20):1462-73
references: 17047195
references: Biochem J. 2002 Jul 15;365(Pt 2):417-28
references: 11952427
references: Trends Biochem Sci. 1997 Apr;22(4):110-3
references: 9149527
references: PLoS One. 2006 Dec 20;1:e107
references: 17205111
references: Oncol Rep. 2003 Sep-Oct;10(5):1375-80
references: 12883710
references: JAMA. 2004 Aug 25;292(8):943-51
references: 15328326
references: Cell Metab. 2005 Jun;1(6):357-8
references: 16054083
references: J Virol. 1998 Sep;72(9):7583-8
references: 9696857
references: Cell Metab. 2006 Mar;3(3):187-97
references: 16517406
references: J Biol Chem. 1993 Jan 25;268(3):1868-75
references: 8420961
references: J Biol Chem. 1988 Jun 5;263(16):7767-75
references: 2897364
references: Mol Cell Biol. 2003 Oct;23(20):7315-28
references: 14517300
references: Mol Cell Biol. 1997 Sep;17(9):5255-68
references: 9271403
references: Biochem J. 2004 Jan 15;377(Pt 2):347-55
references: 14561215
references: J Biochem. 1990 Oct;108(4):642-5
references: 1963434
references: Proteomics. 2003 Aug;3(8):1620-32
references: 12923786
references: Carcinogenesis. 2004 Jun;25(6):1005-10
references: 14764459
references: Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1329-38
references: 16439467
references: Genes Dev. 2001 Nov 15;15(22):2922-33
references: 11711427
references: Biochem J. 2000 Nov 15;352 Pt 1:109-15
references: 11062063
references: Cell. 2003 Nov 26;115(5):629-40
references: 14651853
references: J Biol Chem. 2006 Jan 13;281(2):977-81
references: 16263703
references: Cancer Res. 2006 Sep 15;66(18):8927-30
references: 16982728
references: Prog Exp Tumor Res. 1978;22:190-274
references: 149996
references: J Biol Chem. 2006 Sep 15;281(37):27643-52
references: 16847060
references: J Biol Chem. 2000 Jul 21;275(29):21797-800
references: 10823814
references: Cell. 2006 Jul 14;126(1):107-20
references: 16839880
references: J Biol Chem. 1995 Apr 28;270(17):10342-50
references: 7730341
references: Nat Genet. 1998 Nov;20(3):291-3
references: 9806551
references: Biochem J. 1996 May 15;316 ( Pt 1):183-91
references: 8645203
references: Science. 2000 Mar 17;287(5460):2017-9
references: 10720328
references: J Clin Oncol. 2005 Feb 20;23(6):1136-43
references: 15718309
references: Biochem J. 2004 Feb 15;378(Pt 1):17-20
references: 14683524
references: Nat Med. 2006 Nov;12(11):1241-3
references: 17088888
references: Mol Cell Biol. 2000 May;20(9):3125-36
references: 10757797
references: Arch Biochem Biophys. 2005 Jan 15;433(2):481-6
references: 15581605
references: Physiol Rev. 2007 Jan;87(1):29-67
references: 17237342
references: Cancer Cell. 2005 Jan;7(1):77-85
references: 15652751
references: Am J Med Genet. 2001 Spring;106(1):18-26
references: 11579421
references: J Biol Chem. 2005 Apr 8;280(14 ):13936-43
references: 15695519
references: Biochem J. 1997 Jun 1;324 ( Pt 2):635-43
references: 9182728
references: EMBO J. 2004 Nov 24;23(23):4679-89
references: 15526035
references: Cell Metab. 2005 Jun;1(6):409-14
references: 16054090
references: Novartis Found Symp. 2001;240:251-60; discussion 260-4
references: 11727934
references: J Biol Chem. 2000 Mar 10;275(10):7087-94
references: 10702275
references: J Natl Cancer Inst. 2004 Dec 15;96(24):1805-6
references: 15601632
references: Science. 2000 Feb 4;287(5454):848-51
references: 10657297
references: Nature. 1988 Jul 28;334(6180):320-5
references: 2839775
references: Science. 2006 Jun 16;312(5780):1650-3
references: 16728594
references: Trends Endocrinol Metab. 2002 Mar;13(2):75-8
references: 11854022
references: Mol Cell. 1998 Feb;1(3):327-36
references: 9660917
references: Carcinogenesis. 2006 May;27(5):925-35
references: 16361271
references: Br J Cancer. 2004 Jun 14;90(12):2390-6
references: 15150555
references: Cancer Res. 2001 Jul 15;61(14):5595-600
references: 11454713
references: Eur J Biochem. 1992 May 1;205(3):1187-93
references: 1374334
references: Nature. 2003 Aug 21;424(6951):952-6
references: 12931191
references: Carcinogenesis. 2005 Mar;26(3):531-9
references: 15604095
references: Hum Mol Genet. 2005 Dec 15;14(24):3857-64
references: 16278235
references: FEBS Lett. 1991 Dec 9;294(3):225-8
references: 1661684
references: J Biol Chem. 1990 Jun 5;265(16):9090-7
references: 2140569