title: Biological and therapeutic significance of MUC1 with sialoglycans in clear cell adenocarcinoma of the ovary.
abstract: A monoclonal antibody (mAb) MY.1E12 was applied to detect MUC1 with sialylated glycans in a total of 55 formalin-fixed, paraffin-embedded surgical specimens of ovarian clear cell adenocarcinomas. A reverse correlation between the binding levels of this mAb and patient survival was demonstrated. To examine the role of MUC1 in ovarian clear cell carcinomas, two cDNA encoding MUC1 were transfected into ES-2 ovarian clear cell carcinoma cells. By comparing these cells, the role of MUC1 in tumorigenicity, chemosensitivity and survival under anoikis conditions were assessed. The results indicate that MUC1 expressed on ovarian clear cell carcinoma cells is causally involved in the malignant behavior.
authors: Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
authors: Yutaka
authors: Y
authors: Tamada
authors: Hideyuki
authors: H
authors: Takeuchi
authors: Nao
authors: N
authors: Suzuki
authors: Nobuyuki
authors: N
authors: Susumu
authors: Daisuke
authors: D
authors: Aoki
authors: Tatsuro
authors: T
authors: Irimura
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D000368:Aged; D000818:Animals; D023102:Anoikis / Q000187:drug effects / Q000502:physiology; D000911:Antibodies, Monoclonal; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D018396:Mucin-1 / Q000276:immunology*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D017239:Paclitaxel / Q000008:administration & dosage; D016612:Paraffin Embedding; D011379:Prognosis; D012794:Sialic Acids / Q000378:metabolism*; D015996:Survival Rate
chemical_list: D000911:Antibodies, Monoclonal; D018396:Mucin-1; D012794:Sialic Acids; D017239:Paclitaxel; D002945:Cisplatin
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