Effect of oral tetracycline on iron absorption from iron(III)-hydroxide polymaltose complex in patients with iron deficiency anemia / a single-centre randomized controlled isotope study.
The study was carried out as an open-label, laboratory-blind, single-dose, randomized, two-period crossover, isotope efficacy study. Twenty-two patients with iron-deficiency anemia were enrolled in the study. The study consisted of two treatment phases of 15 days each, including blood sample measurements for Fe-59 activity. The two treatments were given orally. Treatment A was Fe-59 labeled iron(III)-hydroxide polymaltose complex (IPC, Maltofer) equivalent to 100 mg elemental iron given orally. Treatment B consisted of Fe-59 labeled IPC complex equivalent to 100 mg elemental iron and 500 mg tetracycline HCl (CAS 64-75-5) given orally. No differences between the two treatment groups with regard to the erythrocyte iron uptake were found, and thus IPC can be used with tetracycline, if necessary.
Potgieter
Maria A
MA
Farmovs-Parexel, Bloemfontein, South Africa. Linda.Potgieter@PAREXEL.com
Potgieter
Johannes H
JH
Venter
Cornea
C
Venter
Jan L
JL
Geisser
Peter
P
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004347:Drug Interactions; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005290:Ferric Compounds / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000097:blood / Q000493:pharmacokinetics*; D007502:Iron Chelating Agents / Q000494:pharmacology; D007504:Iron Radioisotopes / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011786:Quality Control; D018401:Sample Size; D016037:Single-Blind Method; D013752:Tetracycline / Q000097:blood / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D005290:Ferric Compounds; D006454:Hemoglobins; D007502:Iron Chelating Agents; D007504:Iron Radioisotopes; C021024:ferric hydroxide; D005293:Ferritins; D007501:Iron; D013752:Tetracycline; C013276:teferrol