title: The antifungal polyketide ambruticin targets the HOG pathway.
abstract: The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of action has not yet been elucidated. Here we present evidence that ambruticin exerts its effect by targeting HOG, the osmotic stress control pathway, through Hik1, a group III histidine kinase.
authors: Kosan Biosciences Inc, Hayward, CA 94545, USA.
authors: Leandro
authors: L
authors: Vetcher
authors: Hugo G
authors: HG
authors: Menzella
authors: Toshiaki
authors: T
authors: Kudo
authors: Takayuki
authors: T
authors: Motoyama
authors: Leonard
authors: L
authors: Katz
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D015153:Blotting, Western; D005658:Fungi / Q000187:drug effects*; D005990:Glycerol / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics*; D009994:Osmolar Concentration; D010766:Phosphorylation; D011714:Pyrans / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D015398:Signal Transduction / Q000187:drug effects*; D015003:Yeasts / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D011714:Pyrans; D029701:Saccharomyces cerevisiae Proteins; C088589:HOG1 protein, S cerevisiae; D020928:Mitogen-Activated Protein Kinases; D005990:Glycerol; C014964:ambruticin
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