title: Fixation of experimental osteotomies with bioabsorbable SR-polylactide-polyglycolide (80/20) polymeric rods.
abstract: Self-reinforced polylactide-polyglycolide (80/20) composite rods, 2 mm in diameter and 36 mm in length, were implanted into the dorsal subcutaneous tissue of 20 rabbits. Osteotomies of the distal femur were fixed with these rods (2x15 mm) in the rabbits. The follow-up times varied from 3 to 104 weeks. After sacrifice, three-point bending and shear tests and molecular weight measurements were performed for subcutaneously placed rods. Radiological, histological, microradiographic, oxytetracycline-fluorescence, and histomorphometrical studies of the osteotomized and intact control femora were performed. After 6 weeks the mechanical properties had decreased significantly, but osteotomies had healed uneventfully. The present investigation showed that the mechanical strength and fixation properties of SR-Polylactide-glycolide (80/20) rods are suitable for fixation of cancellous bone osteotomies in rabbits provided that the operative technique is correct. The present article is the first report on the application of these rods for fixation of cancellous bone osteotomies.
authors: Department of Orthopaedics and Traumatology, University of Helsinki and Helsinki University Central Hospital, P.O. Box 266, Helsinki 00029 HUS, Finland.
authors: Eeva
authors: E
authors: Mäkelä
authors: E Antero
authors: EA
authors: Mäkelä
authors: Esa K
authors: EK
authors: Partio
authors: Timo
authors: T
authors: Juutilainen
authors: Kimmo
authors: K
authors: Lähteenkorva
authors: Pertti
authors: P
authors: Törmälä
authors: Pentti
authors: P
authors: Rokkanen
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000648:ultrastructure; D005500:Follow-Up Studies; D048091:Guided Tissue Regeneration / Q000379:methods; D019344:Lactic Acid / Q000737:chemistry*; D008297:Male; D008954:Models, Biological; D009984:Orthopedic Fixation Devices; D010027:Osteotomy; D010118:Oxytetracycline / Q000494:pharmacology; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011817:Rabbits; D011859:Radiography
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D010118:Oxytetracycline
references: J Biomed Mater Res. 1991 Jan;25(1):1-22
references: 1850429
references: J Biomed Mater Res. 1971;5(2):43-58
references: 5575328
references: J Oral Surg. 1971 Jun;29(6):393-7
references: 4997469
references: Clin Orthop Relat Res. 1992 Oct;(283):237-43
references: 1327604
references: Clin Orthop Relat Res. 1991 Jul;(268):260-9
references: 2060218
references: Am J Pathol. 1938 Mar;14(2):237-43
references: 19970387
references: Clin Mater. 1994;17(3):119-23
references: 10150598
references: J Bone Joint Surg Am. 1994 Mar;76(3):319-24
references: 8126036
references: Biomaterials. 1998 Aug;19(16):1419-23
references: 9794512
references: Clin Orthop Relat Res. 1995 Aug;(317):246-53
references: 7671487
references: Lancet. 1985 Jun 22;1(8443):1422-4
references: 2861365
references: J Bone Joint Surg Am. 1992 Aug;74(7):1021-31
references: 1325971
references: Arch Surg. 1966 Nov;93(5):839-43
references: 5921307
references: Biomaterials. 1991 Jan;12 (1):32-6
references: 2009343
references: J Orthop Sci. 2002;7(5):549-56
references: 12355129
references: Clin Orthop Relat Res. 1992 Dec;(285):263-72
references: 1332836
references: Arch Orthop Trauma Surg. 1998;117(4-5):197-204
references: 9581244
references: Clin Mater. 1992;10(1-2):29-34
references: 10149977
references: Biomaterials. 2001 Sep;22(18):2557-61
references: 11516088
references: Arch Surg. 1970 Apr;100(4):486-90
references: 5417172
references: Arch Orthop Trauma Surg. 1986;106(1):1-4
references: 3032127