title: Plasma from women with preeclampsia has a low lipid and ketone body content--a nuclear magnetic resonance study.
abstract: OBJECTIVE
  Using (1)H-nuclear magnetic resonance spectroscopy and chemometrics, we sought to establish the metabolic profile for preeclampsia and to identify biomarkers that would permit a distinction between women with a normal pregnancy and those suffering from preeclampsia.
  
  
  METHODS
  Plasma samples from 11 normotensive pregnant women and 11 women with preeclampsia were analyzed. Principal component analysis was applied to differentiate between the two groups of patients.
  
  
  RESULTS
  Lipid concentrations were found to be significantly lower in the plasma of patients suffering from preeclampsia than those in normotensive pregnant women (p = 0.031). There is also evidence to suggest that ketone body constituents may contribute to the discrimination.
  
  
  CONCLUSIONS
  (1)H-nuclear magnetic resonance-based metabolic profiling can detect patients with preeclampsia.
authors: School of Chemistry, University of Leeds, Leeds, UK.
authors: Elizabeth
authors: E
authors: Turner
authors: Jennifer A
authors: JA
authors: Brewster
authors: Nigel A B
authors: NA
authors: Simpson
authors: James J
authors: JJ
authors: Walker
authors: Julie
authors: J
authors: Fisher
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007657:Ketone Bodies / Q000097:blood*; D008055:Lipids / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis; D011247:Pregnancy; D025341:Principal Component Analysis
chemical_list: D007657:Ketone Bodies; D008055:Lipids