title: Progressive multicystic encephalopathy: is there more than hypoxia-ischemia?
abstract: Progressive multicystic encephalopathy following prenatal or perinatal hypoxia-ischemia is a well-described phenomenon in the literature. The authors report on a term infant with a devastating encephalopathy and severe neuronal dysfunction immediately after delivery without a known antecedent of prenatal or perinatal hypoxia or distress. Clinical and paraclinical findings in the patient are compared with those described in the literature. The authors focus on the specific results guiding to the final diagnosis of progressive multicystic encephalopathy and the timing of morphologic changes. As in this case, if the criteria of an acute hypoxic event sufficient to cause neonatal encephalopathy are not met, then factors other than hypoxia-ischemia may be leading to progressive multicystic encephalopathy.
authors: Department of Neonatology, University Charité, Berlin, Germany. lars.garten@charite.de
authors: Lars
authors: L
authors: Garten
authors: Dieter
authors: D
authors: Hueseman
authors: Gisela
authors: G
authors: Stoltenburg-Didinger
authors: Ursula
authors: U
authors: Felderhoff-Mueser
authors: Katharina
authors: K
authors: Weizsaecker
authors: Ianina
authors: I
authors: Scheer
authors: Eugen
authors: E
authors: Boltshauser
authors: Michael
authors: M
authors: Obladen
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D005315:Fetal Diseases / Q000209:etiology* / Q000473:pathology; D005316:Fetal Distress / Q000150:complications*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology* / Q000473:pathology; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods; D011247:Pregnancy