Rhythmic pattern in pain and their chronotherapy.
Pain control is one of the most important therapeutic priorities; nonetheless, inadequate pain relief remains a significant health care issue. Thus, it is important to determine whether the analgesic effect can be improved by using the chronopharmacological approach. This paper reviews the data on the rhythmic patterns in pain level and their chronotherapy. It underlines the major issues and problems related to the development of chronotherapeutic strategies, and it examines emerging aspects of new drug-delivery systems for achieving such.
Bruguerolle
Bernard
B
Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5, France. bernard.bruguerolle@medecine.univ-mrs.fr
Labrecque
Gaston
G
D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm / Q000502:physiology*; D016503:Drug Delivery Systems; D006801:Humans; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology*; D013813:Therapy, Computer-Assisted
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal