Lower weight gain and higher expression and blood levels of adiponectin in rats fed medium-chain TAG compared with long-chain TAG.
Previous studies demonstrated that, compared with long-chain TAG (LCT), dietary medium-chain TAG (MCT) could improve glucose tolerance in rats and humans. It has been well established that adiponectin acts to increase insulin sensitivity. The effects of dietary MCT on adiponectin serum concentration and mRNA levels in adipose tissue were studied in rats. Male Sprague-Dawley rats were fed a diet containing 20% MCT or LCT for 8 wk. After 6 wk of dietary treatment, an oral glucose tolerance test was performed. Rats fed the MCT diet had less body fat accumulation than those fed the LCT diet (P < 0.01). The cell diameter of the perirenal adipose tissue, one of the abdominal adipose tissues, was smaller (P < 0.01) in the MCT diet group. The serum adiponectin concentration was higher (P < 0.01) in the MCT diet group than in the LCT diet group. The adiponectin content in the perirenal adipose tissue was higher (P < 0.01) in the MCT diet group. The MCT-fed group had a higher adiponectin mRNA level in their perirenal adipose tissue (P < 0.05). The increase of the plasma glucose concentration after glucose administration (area under the curve) was smaller (P < 0.01) in the MCT diet group than in the LCT diet group. These findings suggest that dietary MCT, compared with LCT, results in a higher serum adiponectin level with transcriptional activation of the adiponectin gene in rats. We speculate that improved glucose tolerance in rats fed an MCT diet may be, at least in part, ascribed to this higher serum adiponectin level.
Takeuchi
Hiroyuki
H
Division of Healthcare Science, Research Laboratory, Nisshin Oillio Group, Yokosuka, Kanagawa 239-0832, Japan. h-takeuchi@nisshin-oillio.com
Noguchi
Osamu
O
Sekine
Seiji
S
Kobayashi
Aiko
A
Aoyama
Toshiaki
T
D052242:Adiponectin / Q000096:biosynthesis / Q000097:blood*; D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage*; D004435:Eating; D005227:Fatty Acids / Q000008:administration & dosage; D007328:Insulin / Q000097:blood; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000008:administration & dosage / Q000494:pharmacology*
D052242:Adiponectin; D001786:Blood Glucose; D004041:Dietary Fats; D005227:Fatty Acids; D007328:Insulin; D012333:RNA, Messenger; D014280:Triglycerides
Nat Med. 2002 Nov;8(11):1288-95
12368907
Endocr Rev. 1999 Oct;20(5):649-88
10529898
Lipids. 1987 Jun;22(6):429-34
3613874
Am J Clin Nutr. 1983 Jan;37(1):1-4
6849272
Endocrinology. 1998 Dec;139(12):4998-5005
9832439
J Nutr. 2001 Nov;131(11):2853-9
11694608
Am J Clin Nutr. 1982 Apr;35(4):678-82
7072620
Mol Endocrinol. 1996 Nov;10 (11):1457-66
8923470
Diabetes. 1992 May;41(5):641-7
1568535
Nat Med. 2002 Jul;8(7):731-7
12068289
Horm Res. 2003;60 Suppl 3:56-9
14671398
J Lipid Res. 1968 Jan;9(1):110-9
4295346
J Nutr. 2003 Apr;133(4):1088-93
12672924
Diabetes. 2002 Jun;51(6):1884-8
12031977
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2005-10
11172066
J Clin Endocrinol Metab. 2001 May;86(5):1930-5
11344187
Exp Biol Med (Maywood). 2003 Nov;228(10):1111-7
14610248
Am J Physiol. 1984 Aug;247(2 Pt 1):E181-9
6380306
J Nutr. 1978 Apr;108(4):613-20
24679
Curr Atheroscler Rep. 1999 Nov;1(3):215-20
11122713
Nat Med. 2001 Aug;7(8):941-6
11479627
Lancet. 2002 Jul 6;360(9326):57-8
12114044
Nat Med. 2001 Aug;7(8):947-53
11479628
Int J Obes. 1983;7(3):263-70
6684102
Diabetes. 2001 Sep;50(9):2094-9
11522676
J Nutr. 2002 Mar;132(3):329-32
11880549
Am J Clin Nutr. 1986 Nov;44(5):630-4
3532757
Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):29-33
14551151
J Biol Chem. 2001 Nov 2;276(44):41245-54
11533050
Obes Res. 2003 Jun;11(6):734-44
12805394
J Nutr. 1995 Apr;125(4):920-5
7722695
Ann N Y Acad Sci. 2002 Jun;967:329-35
12079860
J Nutr. 1993 Nov;123(11):1939-51
8229312
Obes Res. 2003 Mar;11(3):368-72
12634431
J Clin Endocrinol Metab. 2003 Oct;88(10):4823-31
14557461
Lipids. 1987 Jun;22(6):442-4
3613876
J Nutr Sci Vitaminol (Tokyo). 2002 Dec;48(6):524-9
12775120