title: Dielectrophoretic manipulation and real-time electrical detection of single-nanowire bridges in aqueous saline solutions.
abstract: Dielectrophoretic manipulation of nanoscale materials is typically performed in nonionic, highly insulating solvents. However, biomolecular recognition processes, such as DNA hybridization and protein binding, typically operate in highly conducting, aqueous saline solutions. Here, we report investigations of the manipulation and real-time detection of individual nanowires bridging microelectrode gaps in saline solutions. Measurements of the electrode impedance versus frequency show a crossover in behavior at a critical frequency that is dependent on the ionic strength. We demonstrate that by operating above this critical frequency, it is possible to use dielectrophoresis to manipulate nanowires across electrode gaps in saline solutions. By using electrical ground planes and nulling schemes to reduce the background currents, we further demonstrate the ability to electrically detect bridging and unbridging events of individual nanowires in saline solutions. The ability to both manipulate and detect bridging events with electrical signals provides a pathway toward automated assembly of nanoscale devices that incorporate biomolecular recognition elements.
authors: Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors: Matthew S
authors: MS
authors: Marcus
authors: Lu
authors: L
authors: Shang
authors: Bo
authors: B
authors: Li
authors: Jeremy A
authors: JA
authors: Streifer
authors: Joseph D
authors: JD
authors: Beck
authors: Edward
authors: E
authors: Perkins
authors: Mark A
authors: MA
authors: Eriksson
authors: Robert J
authors: RJ
authors: Hamers
mesh_terms: D003199:Computer Systems; D004553:Electric Conductivity; D004563:Electrochemistry / Q000379:methods*; D004586:Electrophoresis / Q000379:methods*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing / Q000379:methods; D008846:Micromanipulation / Q000379:methods*; D008968:Molecular Conformation; D036103:Nanotechnology / Q000379:methods*; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D012965:Sodium Chloride / Q000737:chemistry*; D012996:Solutions; D014867:Water / Q000737:chemistry*
chemical_list: D046911:Macromolecular Substances; D012996:Solutions; D014867:Water; D012965:Sodium Chloride