title: [Effect of p53 gene knockout on cell migration].
abstract: OBJECTIVE
  To investigate the role of p53 gene in serum-induced cell migration.
  
  
  METHODS
  The effects of p53 knockout on serum-induced formation of lamellipodia and cell migration were observed using Transwell cell migration system.
  
  
  RESULTS
  p53(+/+) cells developed lamellipodia upon serum stimulation and showed enhanced activity of cell migration, but these effects were not observed in p53 knockout cells after serum stimulation.
  
  
  CONCLUSIONS
  p53 plays a role in serum-induced cell migration.
authors: Department of Pathophysiology and Key Laboratory of Proteomics of Gongdong Province, Southern Medical University, Guangzhou 510515, China.
authors: Xiao-Wei
authors: XW
authors: Gong
authors: Jie
authors: J
authors: Wei
authors: Yu-Sheng
authors: YS
authors: Li
authors: Wei-Wei
authors: WW
authors: Cheng
authors: Xu
authors: X
authors: Wang
authors: Peng
authors: P
authors: Deng
authors: Yong
authors: Y
authors: Jiang
mesh_terms: D000818:Animals; D002460:Cell Line; D002465:Cell Movement / Q000235:genetics*; D005786:Gene Expression Regulation; D055786:Gene Knockout Techniques; D051379:Mice; D011554:Pseudopodia / Q000235:genetics / Q000378:metabolism; D044967:Serum / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency* / Q000235:genetics* / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53