title: Stable stochastic dynamics in yeast cell cycle.
abstract: Chemical reactions in cells are subject to intense stochastic fluctuations. An important question is how the fundamental physiological behavior of the cell is kept stable against those noisy perturbations. In this study, a stochastic model of the cell cycle of budding yeast was constructed to analyze the effects of noise on the cell-cycle oscillation. The model predicts intense noise in levels of mRNAs and proteins, and the simulated protein levels explain the observed statistical tendency of noise in populations of synchronous and asynchronous cells. Despite intense noise in levels of proteins and mRNAs, the cell cycle is stable enough to bring the largely perturbed cells back to the physiological cyclic oscillation. The model shows that consecutively appearing fixed points are the origin of this stability of the cell cycle.
authors: Department of Computational Science and Engineering, Nagoya University, Nagoya, Japan.
authors: Yurie
authors: Y
authors: Okabe
authors: Masaki
authors: M
authors: Sasai
mesh_terms: D001671:Biochemistry / Q000379:methods; D002384:Catalysis; D002453:Cell Cycle; D003198:Computer Simulation; D015966:Gene Expression Regulation, Fungal; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D009991:Oscillometry; D010766:Phosphorylation; D011506:Proteins / Q000737:chemistry; D012333:RNA, Messenger / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000502:physiology*; D013269:Stochastic Processes; D013997:Time Factors
chemical_list: D011506:Proteins; D012333:RNA, Messenger
references: Mol Biol Cell. 1998 Dec;9(12):3273-97
references: 9843569
references: Prog Cell Cycle Res. 2003;5:361-7
references: 14593730
references: Philos Trans R Soc Lond B Biol Sci. 1998 Dec 29;353(1378):2063-76
references: 10098216
references: Biophys J. 2006 Sep 1;91(5):L54-6
references: 16815898
references: Nature. 2006 Jun 15;441(7095):840-6
references: 16699522
references: Science. 2004 Jun 18;304(5678):1811-4
references: 15166317
references: Mol Biol Cell. 2002 Jan;13(1):52-70
references: 11809822
references: Curr Opin Cell Biol. 1999 Feb;11(1):68-80
references: 10047527
references: J Cell Biol. 1995 Aug;130(3):687-700
references: 7622568
references: Nature. 2006 Nov 30;444(7119):643-6
references: 17122776
references: Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4781-6
references: 15037758
references: Mol Biol Cell. 1998 Jul;9(7):1627-31
references: 9658159
references: J Theor Biol. 1998 Nov 7;195(1):69-85
references: 9802951
references: Science. 2002 Aug 16;297(5584):1183-6
references: 12183631
references: Nat Rev Mol Cell Biol. 2001 Dec;2(12):908-16
references: 11733770
references: Microbiol Mol Biol Rev. 1998 Dec;62(4):1191-243
references: 9841670
references: Nature. 2003 Apr 10;422(6932):633-7
references: 12687005
references: J Cell Biol. 1998 Sep 7;142(5):1301-12
references: 9732290
references: Mol Syst Biol. 2006;2:2006.0027
references: 16738571
references: Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2374-9
references: 12606710
references: Curr Opin Cell Biol. 2002 Apr;14(2):237-45
references: 11891124
references: Science. 2005 Sep 23;309(5743):2010-3
references: 16179466
references: Mol Cell Proteomics. 2002 Apr;1(4):323-33
references: 12096114
references: Biochem Soc Trans. 2003 Dec;31(Pt 6):1526-9
references: 14641104
references: Mol Biol Cell. 2000 Jan;11(1):369-91
references: 10637314
references: Trends Genet. 1996 Oct;12(10):405-12
references: 8909137
references: Mol Biol Cell. 2004 Aug;15(8):3841-62
references: 15169868
references: PLoS Comput Biol. 2006 Nov 17;2(11):e147
references: 17112311
references: Nature. 2006 Feb 16;439(7078):856-60
references: 16482159