title: Influence of a nanometer-scale surface enhancement on de novo bone formation on titanium implants: a histomorphometric study in human maxillae.
abstract: In this prospective randomized controlled clinical study, small titanium implants were placed in posterior maxillae for the purpose of assessing the rate and extent of new bone development. Nine pairs of site evaluation implants were placed in posterior areas of maxillae and retrieved with trephine drills after 4 or 8 weeks of unloaded healing. The amount of bone in linear contact (%) with the implant surface was used to determine the osteoconductive potential of the implant surface. Implant surfaces were dual acid etched (n = 9) (controls) or dual acid etched and further conditioned with nanometer-scale crystals of calcium phosphate (n = 9) (test implants), and the surfaces were compared. The implants and surrounding tissues were processed for histologic analysis. The mean bone-to-implant contact value for the test surface was significantly increased over that of the control implants at both time intervals (P <.01). For the implants/patients included in this study, the addition of a nanometer-scale calcium phosphate treatment to a dual acid-etched implant surface appeared to increase the extent of bone development after 4 and 8 weeks of healing.
authors: Department of Oral and Maxillofacial Surgery/Pathology, Academic Centre for Dentistry Amsterdam, VU Medical Center, Amsterdam, The Netherlands.
authors: Ronnie J
authors: RJ
authors: Goené
authors: Tiziano
authors: T
authors: Testori
authors: Paolo
authors: P
authors: Trisi
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D020099:Coated Materials, Biocompatible; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004311:Double-Blind Method; D017886:Durapatite; D006801:Humans; D008437:Maxilla / Q000601:surgery; D053758:Nanoparticles; D016348:Osseointegration / Q000502:physiology*; D011446:Prospective Studies; D013499:Surface Properties; D014025:Titanium
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D017886:Durapatite; D014025:Titanium