title: Duration-dependent susceptibility of endodontic pathogens to calcium hydroxide and chlorhexidene gel used as intracanal medicament: an in vitro evaluation.
abstract: The aim of this study was to evaluate the effective duration of antimicrobial activity of a calcium hydroxide-based medicament (Apex Cal) and 2% chlorhexidene gluconate gel against selected endodontic pathogens (Enterococcus faecalis, Candida albicans, Porphyromonas gingivalis, and Prevotella intermedia). The agar diffusion test was used to determine the antimicrobial activity. Chlorhexidene gluconate gel showed the largest inhibitory zones. The antimicrobial action of both medicaments decreased significantly with time, with calcium hydroxide showing no antimicrobial action after 72 hours. In conclusion, 2% chlorhexidene gel showed better antimicrobial activity than calcium hydroxide, and the effective antimicrobial action of both medicaments decreased after 48 hours.
authors: Department of Conservative Dentistry and Endodontics, College of Dental Surgery, Saveetha University, Chennai, Tamil Nadu, India. prasu_endo@yahoo.com
authors: Prasanna
authors: P
authors: Neelakantan
authors: Kavitha
authors: K
authors: Sanjeev
authors: C V
authors: CV
authors: Subbarao
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002126:Calcium Hydroxide / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002710:Chlorhexidine / Q000494:pharmacology*; D015169:Colony Count, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects; D005779:Immunodiffusion; D008826:Microbial Sensitivity Tests; D016966:Porphyromonas gingivalis / Q000187:drug effects; D018713:Prevotella intermedia / Q000187:drug effects; D012388:Root Canal Irrigants / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000891:Anti-Infective Agents, Local; D012388:Root Canal Irrigants; D002126:Calcium Hydroxide; D002710:Chlorhexidine