title: A comparison of mortality, myocardial infarction, and repeated revascularization for sirolimus-eluting and paclitaxel-eluting coronary stents.
abstract: BACKGROUND
  Drug-eluting stents are now used in most percutaneous coronary interventions. There are only 2 approved devices: sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES). Only a few population-based studies have compared their patient outcomes.
  
  
  METHODS
  All New York State patients undergoing SES or PES in nonfederal hospitals in the state between April 1 and December 31, 2004, except those with a previous revascularization, left main coronary artery disease, or a recent myocardial infarction (MI) or shock (4867 patients with PES and 6914 with SES) were followed up through the end of 2005. We compared SES and PES with respect to inhospital and 18-month mortality, 18-month mortality/MI, and subsequent target vessel and target lesion revascularization (TVR and TLR) after adjusting for differences in patient risk factors.
  
  
  RESULTS
  By 18 months after receiving a PES, 4.0% of the patients died compared with 4.1% for SES patients, 5.9% of PES patients experienced mortality/MI compared with 6.3% of SES patients, 6.8% of the PES patients had a subsequent TVR within 18 months compared with 7.8% for SES patients, and 4.5% of the PES patients had a subsequent TLR within 18 months compared with 5.3% for SES patients. The respective adjusted hazards ratios (PES/SES) for these adverse outcomes were 1.02 (95% CI 0.82-1.26, P = .86), 0.94 (95% CI 0.78-1.13, P = .52), 0.89 (95% CI 0.75-1.06, P = .20), and 0.86 (95% CI 0.70-1.05, P = .14).
  
  
  CONCLUSIONS
  Patients receiving PES and SES do not have significantly different 18-month mortality, mortality/MI, subsequent TVR, or subsequent TLR rates.
authors: School of Public Health, University at Albany, State University of New York, Albany, NY 12144-3456, USA. elh03@health.state.ny.us
authors: Edward L
authors: EL
authors: Hannan
authors: Michael
authors: M
authors: Racz
authors: David R
authors: DR
authors: Holmes
authors: Samin
authors: S
authors: Sharma
authors: Stanley
authors: S
authors: Katz
authors: Gary
authors: G
authors: Walford
authors: Spencer B
authors: SB
authors: King
authors: Luther T
authors: LT
authors: Clark
authors: Robert H
authors: RH
authors: Jones
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003331:Coronary Vessels; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality* / Q000628:therapy*; D009204:Myocardial Revascularization / Q000379:methods / Q000706:statistics & numerical data; D017239:Paclitaxel / Q000008:administration & dosage*; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents
chemical_list: D017239:Paclitaxel; D020123:Sirolimus