Copper-catalyzed amidation of sp3 C-H bonds adjacent to a nitrogen atom.
We have developed a novel copper-catalyzed amidation of unactivated sp(3) C-H bonds adjacent to a nitrogen atom by using an inexpensive catalyst-oxidant (CuBr/(t)BuOOH) system under mild conditions. The dephenylation was first found for N-benzylaniline, and the new class of products provide diverse structures for pharmaceuticals and combinatorial chemistry.
Zhang
Yongming
Y
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Fu
Hua
H
Jiang
Yuyang
Y
Zhao
Yufen
Y
D000586:Amination; D000814:Aniline Compounds / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010084:Oxidation-Reduction
D000814:Aniline Compounds; D002244:Carbon; D003300:Copper; D006859:Hydrogen; D009584:Nitrogen