title: The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.
abstract: Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans.
authors: King's College London School of Medicine, Division of Gene and Cell Based Therapy, London, United Kingdom.
authors: Stephan
authors: S
authors: Menzel
authors: Jie
authors: J
authors: Jiang
authors: Nicholas
authors: N
authors: Silver
authors: Joy
authors: J
authors: Gallagher
authors: Juliette
authors: J
authors: Cunningham
authors: Gabriela
authors: G
authors: Surdulescu
authors: Mark
authors: M
authors: Lathrop
authors: Martin
authors: M
authors: Farrall
authors: Tim D
authors: TD
authors: Spector
authors: Swee Lay
authors: SL
authors: Thein
mesh_terms: D001772:Blood Cell Count; D001792:Blood Platelets / Q000166:cytology*; D002896:Chromosomes, Human, Pair 6 / Q000737:chemistry; D021901:DNA, Intergenic / Q000502:physiology*; D004912:Erythrocytes / Q000166:cytology*; D005260:Female; D020570:Genes, myb; D006801:Humans; D008297:Male; D009000:Monocytes / Q000166:cytology*; D020648:Peptide Elongation Factor 1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D021901:DNA, Intergenic; D020648:Peptide Elongation Factor 1