Bone weighs in on obesity.
Obesity, insulin resistance, and diabetes are related disorders of energy metabolism for which therapies are suboptimal. In this issue of Cell, Lee et al. (2007) demonstrate in mice that bone regulates the insulin/glucose axis and energy metabolism, providing a new framework for approaching common disorders of bioenergetics.
Semenkovich
Clay F
CF
Division of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO 63110, USA. teitelbs@wustl.edu
Teitelbaum
Steven L
SL
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology* / Q000628:therapy