Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product--a further simplification of the lactone region.
Analogues of discodermolide in which the complete C-1 to C-7 fragment is replaced with a coumarin moiety display equivalent potency to that of the natural product.
Shaw
Simon J
SJ
Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, CA 94545, USA. shaw@kosan.com
Menzella
Hugo G
HG
Myles
David C
DC
Xian
Ming
M
Smith
Amos B
AB
D000473:Alkanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D001688:Biological Products / Q000737:chemistry* / Q000633:toxicity*; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D015394:Molecular Structure; D011753:Pyrones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*
D000473:Alkanes; D001688:Biological Products; D002219:Carbamates; D003374:Coumarins; D007783:Lactones; D011753:Pyrones; C030123:coumarin; C071229:discodermolide