Hospitalization-based major comorbidity of inflammatory bowel disease in Canada.
OBJECTIVE
To define the patterns of hospitalization for known major comorbidities associated with inflammatory bowel disease (IBD) in Canada.


METHODS
The data source was the Statistics Canada Health Person Oriented Information hospital database (1994/1995 to 2003/2004). The number of stays for a diagnosis of Crohn's disease or ulcerative colitis by the International Classification of Diseases, ninth edition, codes 555 or 556, or the International Classification of Diseases, 10th edition, Canadian Enhancement, codes K50 or K51, was extracted. Age- and sex-specific and age-adjusted rates of hospitalization for selected IBD-related comorbidities were assessed.


RESULTS
Rates of Hodgkin's disease and non-Hodgkin's lymphoma were low in the hospitalized IBD population. Rates for colon cancer, rectal cancer, pulmonary emboli and deep venous thromboembolism were generally higher among IBD patients younger than 50 years of age compared with the non-IBD hospitalized population.


CONCLUSIONS
IBD was associated with life-threatening comorbidities such as venous thromboembolic disease and colon cancer among persons younger than 50 years of age to a greater extent than the general hospitalized population. Recent secular trends in rates of non-Hodgkin's lymphomas will need to be followed to determine whether the whole population, including IBD patients who receive immunomodulating therapies, are at increased risk.
Bernstein
Charles N
CN
Department of Internal Medicine, University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Canada. cbernst@cc.umanitoba.ca
Nabalamba
Alice
A
D002170:Canada / Q000453:epidemiology; D003110:Colonic Neoplasms / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology*; D038801:International Classification of Diseases; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000453:epidemiology; D012004:Rectal Neoplasms / Q000453:epidemiology; D012189:Retrospective Studies; D013923:Thromboembolism / Q000453:epidemiology
Gastroenterology. 2000 Sep;119(3):647-53
10982757
Am J Gastroenterol. 2006 Jan;101(1):110-8
16405542
Cancer. 2001 Feb 15;91(4):854-62
11241255
Gut. 2001 Apr;48(4):526-35
11247898
Thromb Haemost. 2001 Mar;85(3):430-4
11307809
Aliment Pharmacol Ther. 2002 Jan;16(1):51-60
11856078
Gastroenterology. 2002 Jun;122(7):1808-14
12055588
Am J Gastroenterol. 2004 Apr;99(4):650-5
15089897
Gut. 2004 Sep;53(9):1309-13
15306591
Health Rep. 2004 Jul;15(4):25-40
15346726
N Engl J Med. 1990 Nov 1;323(18):1228-33
2215606
Scand J Gastroenterol. 1996 May;31(5):417-27
8734336
Am J Epidemiol. 1999 May 15;149(10):916-24
10342800
Med Care. 2005 Nov;43(11):1130-9
16224307
Am J Gastroenterol. 2001 Feb;96(2):501-7
11232697