Facilitated hexose transporters: new perspectives on form and function.
The recent sequencing of the human genome has resulted in the addition of nine new hGLUT isoforms to the SLC2A family, many of which have widely varying substrate specificity, kinetic behavior, and tissue distribution. This review examines some new hypotheses related to the structure and function of these proteins.
Manolescu
Andrei R
AR
Membrane Protein Research Group, Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.
Witkowska
Kate
K
Kinnaird
Adam
A
Cessford
Tara
T
Cheeseman
Chris
C
D000595:Amino Acid Sequence; D001692:Biological Transport / Q000502:physiology; D002463:Cell Membrane Permeability / Q000502:physiology; D051246:Glucose Transport Proteins, Facilitative / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D006601:Hexoses / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D020033:Protein Isoforms; D013379:Substrate Specificity / Q000502:physiology
D051246:Glucose Transport Proteins, Facilitative; D006601:Hexoses; D020033:Protein Isoforms