title: Minimizing frustration by folding in an aqueous environment.
abstract: Although life as we know it evolved in an aqueous medium, the properties of water are not completely understood. In this review, we focus on the role of water in guiding protein folding and stability. Specifically, we discuss the mechanisms of protein folding in an aqueous environment, the effects of water on the folding energy landscape as well as the transition state ensemble, and interactions of water with the folded state. We show that water cannot be viewed as a passive solvent, but rather, plays a very active role in the life of a protein.
authors: Department of Molecular and Structural Biochemistry, 128 Polk Hall, North Carolina State University, Raleigh, NC 27695-7622, USA. carla_mattos@ncsu.edu <carla_mattos@ncsu.edu>
authors: Carla
authors: C
authors: Mattos
authors: A Clay
authors: AC
authors: Clark
mesh_terms: D017510:Protein Folding; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water
references: J Biol Chem. 1971 Apr 10;246(7):2211-7
references: 5555568
references: Adv Protein Chem. 1988;39:125-89
references: 3072867
references: Proteins. 2004 Feb 1;54(2):247-59
references: 14696187
references: Protein Sci. 1997 Feb;6(2):347-54
references: 9041636
references: Bioinformatics. 2007 Jan 15;23(2):e99-103
references: 17237112
references: J Mol Biol. 2006 Apr 21;358(1):289-309
references: 16497327
references: Proteins. 2007 Jun 1;67(4):1087-95
references: 17397062
references: Philos Trans R Soc Lond B Biol Sci. 2004 Aug 29;359(1448):1225-34; discussion 1234-5
references: 15306378
references: Nature. 2001 Jan 11;409(6817):241-6
references: 11196652
references: Nature. 1990 Aug 2;346(6283):440-5
references: 2377205
references: Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3984-7
references: 15753320
references: Proteins. 2005 Aug 15;60(3):450-63
references: 15937899
references: Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3325-6
references: 14993602
references: Biochemistry. 1992 Dec 29;31(51):12785-91
references: 1334431
references: J Chem Inf Model. 2007 Mar-Apr;47(2):668-75
references: 17266298
references: Biophys J. 2006 Dec 15;91(12):4544-54
references: 16997864
references: Nat Struct Biol. 1999 Mar;6(3):253-60
references: 10074944
references: Trends Biochem Sci. 2003 Jan;28(1):18-25
references: 12517448
references: J Mol Biol. 1993 Jul 20;232(2):660-79
references: 8393941
references: Protein Sci. 2006 Apr;15(4):843-52
references: 16522792
references: Biochemistry. 1988 Jun 14;27(12):4538-41
references: 3166998
references: Proteins. 2005 Aug 15;60(3):433-49
references: 15971206
references: Prog Nucl Magn Reson Spectrosc. 2017 Feb;98-99:20-49
references: 28283085
references: J Mol Biol. 2003 Dec 12;334(5):1077-85
references: 14643667
references: Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):11953-8
references: 14507993
references: J Mol Biol. 2002 May 3;318(3):837-45
references: 12054827
references: Biochemistry. 1993 May 4;32(17):4564-70
references: 7683491
references: J Biol Chem. 1996 Nov 15;271(46):29088-93
references: 8910563
references: Nat Struct Biol. 1997 Jan;4(1):10-9
references: 8989315
references: J Am Chem Soc. 2007 Mar 21;129(11):3168-72
references: 17315992
references: J Mol Biol. 1994 Sep 23;242(3):193-202
references: 8089841
references: C R Biol. 2005 Aug;328(8):701-12
references: 16125648
references: Structure. 1993 Dec 15;1(4):223-6
references: 8081736
references: J Mol Biol. 2003 Oct 10;333(1):211-26
references: 14516754
references: Biochemistry. 2002 Nov 19;41(46):13473-82
references: 12427007
references: Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1335-42
references: 16204884
references: Proteins. 2007 Jun 1;67(4):931-40
references: 17357162
references: Nature. 1979 Feb 8;277(5696):491-2
references: 763335
references: Biotechnol Bioeng. 1999 Apr 20;63(2):242-8
references: 10099601
references: Proteins. 2007 Jun 1;67(4):868-85
references: 17380484
references: J Phys Chem B. 2005 Apr 21;109(15):7488-99
references: 16851860
references: J Biol Chem. 1991 Jun 25;266(18):11686-94
references: 1646814
references: Curr Opin Struct Biol. 2006 Apr;16(2):152-9
references: 16546375
references: Nature. 1989 Mar 9;338(6211):127-32
references: 2465497
references: J Mol Biol. 2004 Sep 3;342(1):299-306
references: 15313625
references: Protein Sci. 1998 Jan;7(1):158-77
references: 9514271
references: Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10533-40
references: 11535820
references: Adv Colloid Interface Sci. 2006 Nov 16;123-126:97-103
references: 16814736
references: Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7888-93
references: 10393917
references: Curr Med Chem. 2004 Dec;11(23):3093-118
references: 15579003
references: Proteins. 2006 Aug 1;64(2):404-21
references: 16700049
references: J Mol Biol. 1991 Sep 20;221(2):669-91
references: 1920440
references: Nat Struct Biol. 2000 Jan;7(1):34-8
references: 10625424
references: Structure. 1994 Jul 15;2(7):641-9
references: 7922041
references: Protein Sci. 2005 Jul;14(7):1911-7
references: 15937286
references: Biochemistry. 2000 Jun 6;39(22):6586-93
references: 10828976
references: Annu Rev Phys Chem. 1997;48:545-600
references: 9348663
references: J Mol Biol. 2001 Aug 10;311(2):409-19
references: 11478869
references: Biochemistry. 2006 May 23;45(20):6458-66
references: 16700556
references: Bioinformatics. 2001 Mar;17(3):284-5
references: 11294795
references: Proc Natl Acad Sci U S A. 1984 Oct;81(19):6014-8
references: 16593516
references: Biochemistry. 2005 Aug 2;44(30):10054-62
references: 16042382
references: Adv Protein Chem. 1959;14:1-63
references: 14404936
references: J Mol Biol. 1997 Nov 21;274(1):132-42
references: 9398521
references: J Mol Biol. 1999 May 7;288(3):461-75
references: 10329154
references: Curr Opin Struct Biol. 2001 Dec;11(6):761-4
references: 11751059
references: Protein Pept Lett. 2005 Feb;12(2):117-22
references: 15723637
references: Phys Rev Lett. 2004 Nov 26;93(22):228104
references: 15601122
references: J Mol Biol. 2005 Jun 17;349(4):872-89
references: 15893325
references: J Mol Biol. 2007 Feb 23;366(3):1016-28
references: 17188296
references: Biochemistry. 2006 Apr 18;45(15):4711-9
references: 16605239
references: J Mol Biol. 1995 Nov 24;254(2):260-88
references: 7490748
references: Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14408-13
references: 15448207
references: Proteins. 2005 Jul 1;60(1):36-45
references: 15856483
references: Proteins. 2000 Feb 15;38(3):261-72
references: 10713987
references: Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13057-61
references: 16916929
references: Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2834-9
references: 14978284
references: Nature. 1989 Jul 13;340(6229):122-6
references: 2739734
references: J Mol Biol. 2006 Apr 14;357(5):1471-82
references: 16488429
references: J Struct Biol. 2007 Apr;158(1):122-8
references: 17184999
references: Biophys Chem. 2005 Apr 1;115(2-3):89-97
references: 15752588
references: Annu Rev Biophys Biomol Struct. 2006;35:389-415
references: 16689642
references: Trends Biochem Sci. 2002 Apr;27(4):203-8
references: 11943548
references: Science. 2004 Sep 10;305(5690):1605-9
references: 15361621
references: Biophys J. 1994 Mar;66(3 Pt 1):601-14
references: 8011893
references: Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):685-90
references: 11805324
references: Curr Opin Struct Biol. 2002 Apr;12(2):161-8
references: 11959492
references: Biochemistry. 1996 Apr 9;35(14):4298-305
references: 8605178
references: Structure. 2003 Jul;11(7):747-51
references: 12842038
references: Proteins. 1990;8(1):6-13
references: 2217164
references: Proteins. 2004 Oct 1;57(1):1-8
references: 15326588
references: Biotechnol Bioeng. 1998 Mar 20;57(6):686-93
references: 10099248
references: Protein Eng. 1994 May;7(5):613-26
references: 8073031
references: Biophys J. 1996 Oct;71(4):2033-9
references: 8889177
references: Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16047-51
references: 12444262
references: J Mol Biol. 2004 Oct 29;343(4):1125-33
references: 15476826
references: Nat Rev Mol Cell Biol. 2006 Nov;7(11):861-6
references: 16955076
references: Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1520-34
references: 17139088
references: Biophys J. 2006 Sep 1;91(5):L48-50
references: 16798814
references: Methods. 2004 Sep;34(1):41-50
references: 15283914
references: Q Rev Biophys. 2005 Nov;38(4):405-10
references: 16934172
references: J Mol Biol. 2006 Jul 14;360(3):715-24
references: 16784752
references: Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11242-7
references: 11572978
references: Biochemistry. 2006 Mar 21;45(11):3473-80
references: 16533028
references: Annu Rev Biophys Biomol Struct. 2005;34:173-99
references: 15869376
references: J Mol Biol. 1988 Jun 20;201(4):751-4
references: 3172202
references: Nature. 2005 Sep 29;437(7059):640-7
references: 16193038
references: J Mol Biol. 1992 Nov 5;228(1):13-22
references: 1447777
references: Proteins. 2007 Mar 1;66(4):804-13
references: 17186526
references: Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1817-22
references: 17267610
references: Protein Sci. 1994 Aug;3(8):1224-35
references: 7987217
references: FEBS J. 2007 May;274(9):2424-36
references: 17419728
references: Science. 1995 Jan 20;267(5196):383-6
references: 7529940
references: Proc Natl Acad Sci U S A. 1989 Jan;86(2):496-9
references: 2536164
references: J Mol Biol. 1988 Aug 5;202(3):637-57
references: 3172231
references: Biochem Biophys Res Commun. 2006 Feb 17;340(3):976-83
references: 16405866
references: Science. 1991 Nov 15;254(5034):974-80
references: 1948083
references: FEBS Lett. 2005 Apr 25;579(11):2254-60
references: 15848154
references: J Biol Chem. 1994 Oct 28;269(43):26722-33
references: 7929406
references: J Mol Biol. 2006 Jul 21;360(4):865-81
references: 16784750
references: Protein Eng. 2003 Jan;16(1):5-9
references: 12646687
references: Biochemistry. 1997 Oct 28;36(43):13143-7
references: 9376374
references: Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3352-7
references: 14988499
references: J Mol Biol. 1999 Jun 11;289(3):547-64
references: 10356328
references: Chem Biol. 1996 Jun;3(6):425-32
references: 8807873
references: Protein Sci. 1999 Apr;8(4):722-30
references: 10211818
references: Q Rev Biophys. 2005 Nov;38(4):385-95
references: 16817982
references: Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15469-72
references: 17030792
references: Nat Struct Biol. 1999 Nov;6(11):987-90
references: 10542081
references: Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4846-51
references: 16551747
references: Protein Sci. 2001 May;10(5):1067-78
references: 11316887
references: J Phys Chem B. 2005 Sep 1;109(34):16529-38
references: 16853101