[Osteonecrosis of the jaws by using bisphosphonates].
The new generation of bisphosphonates are often used in the treatment of osteoporosis or for certain tumors with bone defects. Between the period of September 2005 and May 2006 we have treated 8 patients at our clinic with a bisphosphonate-induced osteonecrosis in the maxillofacial region. All of these patients went through intravenous bisphosphonate treatment earlier. We have chosen two cases, where the appearance of side effects can be named as typical. Based upon the increasing number of international articles reporting and our own experiences in this matter, we would like to draw attention to the importance of prevention in treating these patients. In case of symptoms, if temporary suspension of the bisphosphonate therapy does not have severe consequences, combination of surgical and long-term antibiotic therapy could be the solution.
Vaszilkó
Mihály
M
Semmelweis Egyetem Arc-, AlIcsont-, Szájsebészeti es Fogászati Klinika, Budapest.
Barabás
József
J
Szabó
György
G
Velich
Norbert
N
Cséplo
Kisztina
K
Ujpál
Márta
M
D000368:Aged; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D007568:Jaw / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced*
D004164:Diphosphonates