Terpenoids and flavonoids from Laggera pterodonta.
To study the chemical constituents of aerial parts of Laggera pterodonta (DC.) Benth., the air-dried aerial parts of this plant were powered and extracted with boiling water and purified by silica gel column chromatography and recrystallized. Eleven compounds were obtained from L. pterodonta. They were identified as to be 6-O-beta-D-glucopyranosyl-carvotanacetone (1), pterodontic acid (2), 1beta-hydroxy pterondontic acid (3), pterodontoside A (4), pterodondiol (5), pterodontriol B (6), 5-hydroxy-3,4', 6,7-tetramethoxyflavone (7), artemitin (8), chrysosplenetin B (9), quercetin (10) and beta-sitosterol (11). Compound 1 is a new monoterpene glucoside. Compounds 10 and 11 were isolated from this plant for the first time. Compounds 2 and 5 showed moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Mycobacteium phlei and Bacillus circulans by paper disc diffusion method, while they both displayed no activity against Escherichia coli.
Yang
Guang-Zhong
GZ
Institute of National Medicine, South-Central University for Nationalities, Wuhan 430074, China.
Li
Yun-Fang
YF
Yu
Xin
X
Mei
Zhi-Nan
ZN
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002850:Chromatography, Gel; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011794:Quercetin / Q000737:chemistry / Q000302:isolation & purification; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification; D021241:Spectrometry, Mass, Electrospray Ionization; D013211:Staphylococcus aureus / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*
C541896:6-O-beta-D-glucopyranosyl-carvotanacetone; D000900:Anti-Bacterial Agents; D005419:Flavonoids; D005960:Glucosides; D012717:Sesquiterpenes; D012855:Sitosterols; D013729:Terpenes; C541898:pterodondiol; C541897:pterodontic acid; C025473:gamma-sitosterol; D011794:Quercetin