title: The effect of neurodegenerative diseases on the subventricular zone.
abstract: During brain development, one of the most important structures is the subventricular zone (SVZ), from which most neurons are generated. In adulthood the SVZ maintains a pool of progenitor cells that continuously replace neurons in the olfactory bulb. Neurodegenerative diseases induce a substantial upregulation or downregulation of SVZ progenitor cell proliferation, depending on the type of disorder. Far from being a dormant layer, the SVZ responds to neurodegenerative disease in a way that makes it a potential target for therapeutic intervention.
authors: Institute of Neuroscience and Physiology at Sahlgrenska Academy, Medicinaregat 11, Box 432, s-40530 Göteborg, Sweden. maurice.curtis@neuro.gu.se
authors: Maurice A
authors: MA
authors: Curtis
authors: Richard L M
authors: RL
authors: Faull
authors: Peter S
authors: PS
authors: Eriksson
mesh_terms: D000818:Animals; D006801:Humans; D020547:Lateral Ventricles / Q000473:pathology* / Q000503:physiopathology*; D019636:Neurodegenerative Diseases / Q000473:pathology* / Q000503:physiopathology; D009474:Neurons / Q000473:pathology / Q000502:physiology*