title: Enterovirus surveillance reveals proposed new serotypes and provides new insight into enterovirus 5'-untranslated region evolution.
abstract: Human enteroviruses are currently grouped into five species Human enterovirus A (HEV-A), HEV-B, HEV-C, HEV-D and Poliovirus. During surveillance for enteroviruses serologically non-typable enterovirus strains were found from acute flaccid paralysis patients and healthy individuals. In this study, we report isolates of recently described enterovirus types EV76 and EV90 of HEV-A species and characterize two new enterovirus type candidates, EV96 and EV97, to species HEV-C and HEV-B, respectively. Analysis of partial 3D regions of EV96 strains revealed sequence divergence consistent with several recombination events between EV96, other HEV-C viruses and polioviruses. Phylogenetic analysis of all available 5'-untranslated region sequences of human entero- and rhinovirus prototype strains and 10 simian enterovirus strains suggested interspecies recombination involving this region.
authors: Enterovirus Laboratory, Department of Viral Diseases and Immunology, National Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland.
authors: Teemu
authors: T
authors: Smura
authors: Enterovirus Laboratory, Department of Viral Diseases and Immunology, National Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland.
authors: Soile
authors: S
authors: Blomqvist
authors: Enterovirus Laboratory, Department of Viral Diseases and Immunology, National Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland.
authors: Anja
authors: A
authors: Paananen
authors: Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN-20520 Turku, Finland.
authors: Tytti
authors: T
authors: Vuorinen
authors: National Reference Centres, Public Health Office of the Slovak Republic, Trnavska 52, 82645 Bratislava, Slovak Republic.
authors: Zdenka
authors: Z
authors: Sobotová
authors: State Agency 'Public Health Agency', Virology Laboratory, Klijanu Str. 7, LV-1012 Riga, Latvia.
authors: Veronika
authors: V
authors: Buboviča
authors: M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides of Russian Academy of Medical Science, Kievskoe Shosse 27 km, 142782 Moscow Region, Russian Federation.
authors: Olga
authors: O
authors: Ivanova
authors: Enterovirus Laboratory, Department of Viral Diseases and Immunology, National Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland.
authors: Tapani
authors: T
authors: Hovi
authors: Enterovirus Laboratory, Department of Viral Diseases and Immunology, National Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland.
authors: Merja
authors: M
authors: Roivainen
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics*; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D029821:Enterovirus A, Human / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D019143:Evolution, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012229:Rhinovirus / Q000145:classification / Q000235:genetics; D012703:Serotyping
chemical_list: D020121:5' Untranslated Regions; D004279:DNA, Viral