title: X-linked angiotensin II type 2 receptor gene polymorphism -1332A/G in male patients with essential hypertension.
abstract: BACKGROUND
  The role of AT2R in regulation of blood pressure (BP) was mainly investigated in animal models. It is proposed to be a negative regulator of BP. X-linked AT2R -1332 A/G polymorphism has been denoted as functional. This polymorphism was associated with certain cardiovascular phenotypes in hypertensive patients, but it was poorly investigated in essential hypertension. The aim of our study was to evaluate possible association of -1332 A/G gene polymorphism with essential hypertension in males from Serbian population.
  
  
  METHODS
  The study group included 304 men of Caucasian origin, 190 normotensive (NT) and 114 hypertensive (HT), free of cardiovascular disorders. Genotyping was done by PCR RFLP method.
  
  
  RESULTS
  G/- genotype was in association with HT (OR 1.6, CI=1.0-2.6, p=0.04). Stratification by age (<40 years, mean 31.65+/-5.29 and >40 years, mean 51.36+/-8.32) pronounced significance only in older males (OR 2.4, CI=1.2-5.0, p=0.02). After adjustment for confounding factors the OR for hypertension remained unchanged and significant (adjusted OR 2.3, CI=1.0-5.4, p=0.04).
  
  
  CONCLUSIONS
  Hemizygosity for the G allele was found to be susceptibility factor for hypertension in males. Still, clarifying the role of AT2R in development of human hypertension requires further replication studies in larger and different populations.
authors: VINCA Institute of Nuclear Sciences, Laboratory for Radiobiology and Molecular Genetics, Belgrade, Serbia.
authors: Maja
authors: M
authors: Zivković
authors: Tamara
authors: T
authors: Djurić
authors: Olja
authors: O
authors: Stancić
authors: Dragan
authors: D
authors: Alavantić
authors: Aleksandra
authors: A
authors: Stanković
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000235:genetics; D005787:Gene Frequency; D050172:Genes, X-Linked / Q000235:genetics*; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D044139:Receptor, Angiotensin, Type 2 / Q000235:genetics*; D012307:Risk Factors; D012424:Rural Population; D015022:Yugoslavia / Q000208:ethnology
chemical_list: D044139:Receptor, Angiotensin, Type 2