title: Effect of cholic acid and its keto derivatives on the analgesic action of lidocaine and associated biochemical parameters in rats.
abstract: This study examined the effect of the structure and concentration of cholic acid and its keto derivatives on the local analgesic action of lidocaine in rats, measured by an analgesimetric method. The increase in bile acid concentrations in the administered lidocaine solution increased the duration of local anesthesia. It was found that the introduction of keto groups into the cholic acid molecule yielded derivatives with lower promotory action, i.e. decreased the duration of local anesthesia. The biochemical parameters investigated indicated that the keto derivatives of cholic acid exhibited no toxicity compared to that of cholic acid itself.
authors: Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Novi Sad, Republic of Serbia.
authors: Mihalj
authors: M
authors: Posa
authors: Slavko
authors: S
authors: Kevresan
authors: Momir
authors: M
authors: Mikov
authors: Vera
authors: V
authors: Cirin-Novta
authors: Ksenija
authors: K
authors: Kuhajda
mesh_terms: D000698:Analgesia; D000779:Anesthetics, Local / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport; D002793:Cholic Acids / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D008012:Lidocaine / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D008823:Micelles; D000442:Octanols / Q000737:chemistry; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D000779:Anesthetics, Local; D002793:Cholic Acids; D008823:Micelles; D000442:Octanols; D014867:Water; D008012:Lidocaine
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