[Analgesic effect of interleukin-2 in mouse models of spared nerve injury].
OBJECTIVE
To investigate the analgesic effect of interleukin-2 (IL-2) in mice with spared nerve injury (SNI).


METHODS
IL-2 was intraperitoneally injected in mice with induced SNI, and von Frey Filaments test and cold plate test were carried out to accesses the analgesic effects of IL-2 and the effect of naloxone in antagonizing the effects of IL-2.


RESULTS
IL-2 produced analgesic effects against hyperalgesia and allodynia in mouse models of SNI, and the effect of IL-2 lasted for more than 24 h, showing a double-peak pattern in its action with the two peaks occurring at 30 and 105 min, respectively. The effect of IL-2 could be significantly antagonized by naloxone.


CONCLUSIONS
IL-2 has long-lasting analgesic effects in mouse models of SNI model, showing a double-peak pattern of its action. The analgesic effect of IL-2 is probably mediated by opiate receptor.
Liu
Shan
S
Department of Immunology and Microbiology, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. llllllandsss@sohu.com
Shi
Lin
L
Wang
Jun-Yang
JY
Fan
Gui-Xiang
GX
Yuan
Yu-Kang
YK
D000700:Analgesics / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006930:Hyperalgesia / Q000150:complications / Q000188:drug therapy; D007376:Interleukin-2 / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009270:Naloxone / Q000494:pharmacology; D020196:Trauma, Nervous System / Q000150:complications / Q000188:drug therapy*
D000700:Analgesics; D007376:Interleukin-2; D009270:Naloxone