Association of plasma adiponectin levels with oxidative stress in hemodialysis patients.
BACKGROUND
Recent evidence suggests that oxidative stress may be an instigator of the metabolic syndrome, and adiponectin, an adipocyte-derived polypeptide, may modulate oxidative stress, ameliorating the atherosclerotic process.


OBJECTIVE
Oxidative stress is increased in hemodialysis (HD) patients. We hypothesize that a relationship between plasma levels of adiponectin and markers of inflammation and oxidative stress exists.


RESULTS
In 124 HD patients, plasma adiponectin levels and three separate oxidative stress markers, tumor necrosis factor-alpha as well as high-sensitivity C-reactive protein (hsCRP) were determined. Plasma adiponectin was significantly and negatively correlated with serum hsCRP (r = -0.247, p = 0.008) and plasma malondialdehyde (MDA) levels (r = -0.326; p < 0.001). Multiple regression analyses suggested that plasma MDA, serum HDL cholesterol levels and logarithmically transformed hsCRP were the variables independently associated with plasma adiponectin levels.


CONCLUSIONS
Plasma adiponectin was significantly associated with plasma MDA, serum HDL cholesterol levels and serum hsCRP levels. Our results suggest the possibility that plasma adiponectin may play a role in alleviating oxidative stress in HD patients.
Lim
Paik-Seong
PS
Department of Food Nutrition, Providence University, Taichung, Taiwan, ROC.
Chen
Shun-Liang
SL
Wu
Ming-Ying
MY
Hu
Chuen-Yuh
CY
Wu
Tsai-Kun
TK
D052242:Adiponectin / Q000097:blood* / Q000502:physiology; D000328:Adult; D000368:Aged; D015415:Biomarkers; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007333:Insulin Resistance; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D018384:Oxidative Stress; D006435:Renal Dialysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D002097:C-Reactive Protein