title: Adolescent development of the neural circuitry for thinking about intentions.
abstract: In this fMRI study, we investigated the development during adolescence of the neural network underlying thinking about intentions. A total of 19 adolescent participants (aged 12.1-18.1 years), and 11 adults (aged 22.4-37.8 years), were scanned using fMRI. A factorial design was employed with between-subjects factor age group and within-subjects factor causality (intentional or physical). In both adults and adolescents, answering questions about intentional causality vs physical causality activated the medial prefrontal cortex (PFC), superior temporal sulcus (STS), temporal poles and precuneus bordering with posterior cingulate cortex. In addition, there was a significant interaction between group and task in the medial PFC. During intentional relative to physical causality, adolescents activated part of the medial PFC more than did adults and adults activated part of the right STS more than did adolescents. These results suggest that the neural strategy for thinking about intentions changes between adolescence and adulthood. Although the same neural network is active, the relative roles of the different areas change, with activity moving from anterior (medial prefrontal) regions to posterior (temporal) regions with age.
authors: Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N3AR, UK. s.blakemore@ucl.ac.uk
authors: Sarah-Jayne
authors: SJ
authors: Blakemore
authors: Hanneke
authors: H
authors: den Ouden
authors: Suparna
authors: S
authors: Choudhury
authors: Chris
authors: C
authors: Frith
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003071:Cognition / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology; D006801:Humans; D033182:Intention; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology; D012938:Social Perception; D013850:Thinking; D055815:Young Adult
references: Neuropsychologia. 2000;38(7):1006-17
references: 10775711
references: Neuroimage. 2000 Sep;12(3):314-25
references: 10944414
references: Brain Res. 1979 Mar 16;163(2):195-205
references: 427544
references: Annu Rev Psychol. 1988;39:583-607
references: 3278681
references: Int J Neurol. 1982-1983;16-17:144-54
references: 6765658
references: Cognition. 1995 Nov;57(2):109-28
references: 8556839
references: Cereb Cortex. 1996 Jul-Aug;6(4):551-60
references: 8670681
references: Brain. 1996 Oct;119 ( Pt 5):1763-74
references: 8931596
references: J Cogn Neurosci. 1998 Sep;10(5):640-56
references: 9802997
references: Monogr Soc Res Child Dev. 1998;63(4):i-vi, 1-143
references: 9835078
references: Science. 1999 Mar 19;283(5409):1908-11
references: 10082463
references: Neuroimage. 1999 Jun;9(6 Pt 1):587-97
references: 10334902
references: Nat Neurosci. 1999 Oct;2(10):861-3
references: 10491603
references: Trends Cogn Sci. 2005 Feb;9(2):69-74
references: 15668099
references: Brain. 2002 Aug;125(Pt 8):1808-14
references: 12135971
references: J Cogn Neurosci. 2004 Dec;16(10):1746-72
references: 15701226
references: Science. 2005 Nov 4;310(5749):819-23
references: 16272115
references: Cereb Cortex. 2005 Dec;15(12):1848-54
references: 15758200
references: Trends Cogn Sci. 2005 Dec;9(12):572-7
references: 16271505
references: Neuroimage. 2005 Dec;28(4):787-96
references: 15964210
references: Neuroimage. 2005 Dec;28(4):757-62
references: 16325141
references: Dev Sci. 2006 Jan;9(1):1-8
references: 16445387
references: Dev Sci. 2006 Jan;9(1):11-4
references: 16445389
references: J Child Psychol Psychiatry. 2006 Mar-Apr;47(3-4):296-312
references: 16492261
references: Trends Neurosci. 2006 Mar;29(3):148-59
references: 16472876
references: Nat Rev Neurosci. 2006 Apr;7(4):268-77
references: 16552413
references: Neuron. 2006 May 18;50(4):531-4
references: 16701204
references: Neurosci Lett. 2006 Oct 9;406(3):194-9
references: 16942837
references: Soc Cogn Affect Neurosci. 2006 Sep;1(2):107-21
references: 18985123
references: Neuropsychologia. 2000;38(1):11-21
references: 10617288
references: Neurology. 2000 Jan 11;54(1):180-5
references: 10636145
references: Neurosci Biobehav Rev. 2000 Jan;24(1):13-9
references: 10654655
references: Neuroimage. 2000 Feb;11(2):157-66
references: 10679187
references: Neuropsychologia. 2001;39(1):83-90
references: 11115657
references: Neuroreport. 2001 Feb 12,;12(2):427-33
references: 11209962
references: Brain. 2001 Feb;124(Pt 2):279-86
references: 11157555
references: Brain. 2001 Mar;124(Pt 3):600-16
references: 11222459
references: Neuroimage. 2001 Jul;14(1 Pt 1):170-81
references: 11525326
references: Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11832-5
references: 11562505
references: Nat Rev Neurosci. 2001 Oct;2(10):685-94
references: 11584306
references: J Neurosci. 2001 Nov 15;21(22):8819-29
references: 11698594
references: Dev Neuropsychol. 2001;20(1):385-406
references: 11827095
references: Brain. 2002 Apr;125(Pt 4):752-64
references: 11912109
references: Neuroimage. 2002 May;16(1):61-75
references: 11969318
references: J Cogn Neurosci. 2002 Jul 1;14(5):785-94
references: 12167262
references: Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13336-41
references: 12244209
references: Neuroimage. 2002 Oct;17(2):1080-6
references: 12377180
references: Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15238-43
references: 12417766
references: Nat Neurosci. 2003 Mar;6(3):309-15
references: 12548289
references: Philos Trans R Soc Lond B Biol Sci. 2003 Mar 29;358(1431):459-73
references: 12689373
references: Philos Trans R Soc Lond B Biol Sci. 2003 Mar 29;358(1431):549-59
references: 12689380
references: J Neurosci. 2003 Jun 15;23(12):5258-63
references: 12832550
references: Neuroimage. 2003 Aug;19(4):1835-42
references: 12948738
references: Neuroimage. 2003 Sep;20(1):420-8
references: 14527602
references: Brain. 2004 Apr;127(Pt 4):914-28
references: 14998913
references: Nat Neurosci. 2004 May;7(5):499-500
references: 15077111
references: Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6827-32
references: 15096584
references: Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9
references: 15148381
references: Neuroimage. 2004 Jun;22(2):941-7
references: 15193625
references: Child Dev. 1967 Dec;38(4):1025-34
references: 5583052