The macrolide resistance genes erm(B) and mef(E) are carried by Tn2010 in dual-gene Streptococcus pneumoniae isolates belonging to clonal complex CC271.
The genetic elements carrying macrolide resistance genes in Streptococcus pneumoniae isolates belonging to CC271 were investigated. The international clone Taiwan(19F)-14 was found to carry Tn2009, a Tn916-like transposon containing tet(M) and mef(E). The dual erm(B) mef(E) isolates carried Tn2010, which is similar to Tn2009 with the addition of a putative new transposon, the erm(B) genetic element.
Del Grosso
Maria
M
Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. maria.delgrosso@iss.it
Northwood
John G E
JG
Farrell
David J
DJ
Pantosti
Annalisa
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D004251:DNA Transposable Elements / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics; D018942:Macrolides / Q000494:pharmacology*; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000235:genetics*; D013624:Taiwan
D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements; D018942:Macrolides
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