Synthesis, characterization, and evaluation of phosphated cross-linked konjac glucomannan hydrogels for colon-targeted drug delivery.
Hydrogel systems of konjac glucomannan (KGM) cross-linked with trisodium trimetaphosphate (STMP) were prepared for colon-targeting drug delivery. Swelling degrees of the hydrogels were measured in artificial gastrointestinal fluids and in sodium chloride solution with different concentrations to study their dependence on the cross-linking density and the ionic strength. The absorption of methylene blue was used to characterize the degree of the KGM cross-linking. In vitro release of model drug hydrocortisone was studied in presence and absence of beta -mannanase. KGM cross-linked with STMP was able to retard the release of the poorly water-soluble drug and could be biodegraded enzymatically. Hydrocortisone release was cross-linking density dependent and controlled by degradation of the hydrogles.
Liu
Meimei
M
Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin, PR China.
Fan
Jiangyang
J
Wang
Kang
K
He
Zhimin
Z
D000893:Anti-Inflammatory Agents / Q000737:chemistry; D003106:Colon / Q000378:metabolism*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006854:Hydrocortisone / Q000737:chemistry; D020100:Hydrogels; D008351:Mannans / Q000737:chemistry*; D008751:Methylene Blue; D011122:Polyphosphates / Q000737:chemistry*; D044902:beta-Mannosidase / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D020100:Hydrogels; D008351:Mannans; D011122:Polyphosphates; C022901:(1-6)-alpha-glucomannan; D044902:beta-Mannosidase; C009293:trimetaphosphoric acid; D008751:Methylene Blue; D006854:Hydrocortisone