title: A Dipolar Cycloaddition Approach Toward the Kopsifoline Alkaloid Framework.
abstract: Using a metal-catalyzed domino reaction as the key step, the heterocyclic skeleton of the kopsifoline alkaloid family was constructed by a 1,3-dipolar cycloaddition of a carbonyl ylide dipole derived from a Rh(II)-catalyzed reaction of a diazo ketoester across the indole pi-bond. Ring opening of the resulting 1,3-dipolar cycloadduct followed by a reductive dehydroxylation step resulted in the formation of a critical silyl enol ether necessary for the final F-ring closure of the kopsifoline skeleton.
authors: Department of Chemistry, Emory University, Atlanta, GA 30322, USA.
authors: Xuechuan
authors: X
authors: Hong
authors: Stefan
authors: S
authors: France
authors: Albert
authors: A
authors: Padwa
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