title: Perfusional deficit and the dynamics of cerebral edemas in experimental traumatic brain injury using perfusion and diffusion-weighted magnetic resonance imaging.
abstract: The aim of this work was to characterize edema dynamics, cerebral blood volume, and flow alterations in an experimental model of brain trauma using quantitative diffusion and perfusion magnetic resonance imaging (MRI). Associated with an influx of water in the intracellular space 1-5 h post-trauma as demonstrated by the 40% reduction in apparent diffusion coefficient, a 70-80% reduction in cerebral blood flow was measured within the lesioned region. Transient hypoperfusion (40-50%) was also observed in the non-traumatized contralateral hemisphere, although there was no evidence of edema formation. After the initial cytotoxic edema, a clear evolution toward extracellular water accumulation was observed, demonstrated by an increase in apparent diffusion coefficient.
authors: INSERM U 646, Ingénierie de la Vectorisation Particulaire, Angers, France.
authors: Anne
authors: A
authors: Pasco
authors: Laurent
authors: L
authors: Lemaire
authors: Florence
authors: F
authors: Franconi
authors: Yann
authors: Y
authors: Lefur
authors: Fanny
authors: F
authors: Noury
authors: Jean-Paul
authors: JP
authors: Saint-André
authors: Jean-Pierre
authors: JP
authors: Benoit
authors: Patrick J
authors: PJ
authors: Cozzone
authors: Jean-Jacques
authors: JJ
authors: Le Jeune
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D001929:Brain Edema / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D001930:Brain Injuries / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D008536:Meglumine; D009942:Organometallic Compounds; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine
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