title: Pulmonary inverted Schneiderian papilloma causing high serum levels of carcinoembryonic antigen and squamous cell carcinoma-associated antigen: report of a case.
abstract: We report a rare case of inverted Schneiderian papilloma causing exceedingly high serum levels of carcinoembryonic antigen (CEA) and squamous cell carcinoma-associated antigen (SCC). A 74-year-old man presented with a 6-month history of a productive cough, bloody sputa, and dyspnea. Chest computed tomography showed massive infiltration in the lower lobe with multiple focal soft tissue densities. Blood biochemical analysis revealed a serum CEA level of 107.0 ng/ml (normal <5.0 ng/ml), and an SCC level of 373.0 ng/ml (normal <1.5 ng/ml). Squamous papilloma was diagnosed by histological examination of a bronchoscopic biopsy specimen. To alleviate the patient's symptoms and refine the diagnosis, we performed a right lower lobectomy. The lower lobe of the lung was filled with mucinous sputa and very fragile papillary tumors of various sizes. Microscopic examination revealed papillary growth of stratified epithelial cells with massive mucin production. No nuclear abnormality or invasion of the basal membrane of the tumor cells was observed. Postoperatively, the patient's symptoms resolved quickly, and the serum levels of CEA and SCC decreased to 6.4 ng/ml and 1.7 ng/ml, respectively, within 3 months.
authors: Department of Thoracic Surgery, Osaka City University Hospital, 1-4-3 Asahi-machi, Osaka 545-8585, Japan.
authors: Takashi
authors: T
authors: Iwata
authors: Kiyotoshi
authors: K
authors: Inoue
authors: Noritoshi
authors: N
authors: Nishiyama
authors: Nobuhiro
authors: N
authors: Izumi
authors: Shinjiro
authors: S
authors: Mizuguchi
authors: Ryuhei
authors: R
authors: Morita
authors: Takuma
authors: T
authors: Tsukioka
authors: Shigefumi
authors: S
authors: Suehiro
authors: Naoko
authors: N
authors: Obatake
authors: Kenichi
authors: K
authors: Wakasa
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000276:immunology*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D018308:Papilloma, Inverted / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D015843:Serpins / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D015843:Serpins; C051072:squamous cell carcinoma-related antigen
references: Head Neck. 2005 Jan;27(1):44-8
references: 15459916
references: Pathol Int. 2000 May;50(5):431-9
references: 10849335
references: Ann Thorac Surg. 2004 May;77(5):1845-6
references: 15111209
references: Int J Gynecol Pathol. 1999 Jan;18(1):94-5
references: 9891250
references: Am J Surg Pathol. 1998 Nov;22(11):1328-42
references: 9808125
references: Otolaryngol Head Neck Surg. 1995 Nov;113(5):558-63
references: 7478645
references: J Surg Oncol. 2006 Jan 1;93(1):80-5
references: 16353190
references: Rhinology. 2000 Sep;38(3):97-101
references: 11072653
references: Cancer. 2002 Jan 1;94(1):152-8
references: 11815971
references: Cancer. 1989 Sep 15;64(6):1329-35
references: 2548703