Epigenetic transgenerational toxicology and germ cell disease.
The ability of an environmental exposure (i.e. endocrine disruptor) during sex determination to reprogramme the male germline and promote an epigenetic transgenerational disease phenotype suggests that environmental factors and compounds may permanently alter the germline epigenome. This epigenetic transgenerational phenomenon will be discussed with respect to adult-onset germline disease (e.g. testicular cancer). A thorough literature review is not provided, rather a perspective is provided on how this epigenetic transgenerational toxicology should be considered in germ cell disease and testicular cancer.
Skinner
Michael K
MK
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA, USA. skinner@mail.wsu.edu
D019175:DNA Methylation; D004781:Environmental Exposure; D044127:Epigenesis, Genetic / Q000235:genetics*; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D013736:Testicular Neoplasms / Q000235:genetics*
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