title: Phosphoinositides control epithelial development.
abstract: Epithelial organs consist on layers of cubical cells that separate different compartments. They form a physical barrier that allows the regulated transports of certain molecules and ions. To perform this and other functions epithelial cells require to be highly polarized. The molecular mechanisms that integrate cellular polarity with epithelial architecture are poorly understood. Using a three-dimensional model of epithelial morphogenesis, we have recently reported a molecular mechanism for the formation of the apical membrane and the central lumen.(1) This molecular pathway is initiated by the membrane segregation of phosphoinositides at the apical domain. Apically localized phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P2] recruits the scaffolding protein Annexin2 and the GTPase Cdc42 to generate the apical plasma membrane domain and the central lumen.
authors: Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid-CSIC, Madrid, Spain. fmartin@cbm.uam.es
authors: Fernando
authors: F
authors: Martin-Belmonte
authors: Keith
authors: K
authors: Mostov
mesh_terms: D000818:Animals; D017306:Annexin A2 / Q000378:metabolism / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology; D004848:Epithelium / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism / Q000502:physiology; D010716:Phosphatidylinositols / Q000378:metabolism* / Q000502:physiology; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism
chemical_list: D017306:Annexin A2; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D020764:cdc42 GTP-Binding Protein