title: No association between the DRD3 Ser9Gly polymorphism and schizophrenia.
abstract: OBJECTIVE
  To investigate the association between a Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) and schizophrenia.
  
  
  METHODS
  408 schizophrenic patients and 172 control subjects were compared with regard to their DRD3 Ser9Gly genotypic and allelic frequencies. In addition, we carried out a family-based association study including 183 pedigrees (472 subjects) using the transmission disequilibrium test (TDT).
  
  
  RESULTS
  No significant differences of genotype or homozygosity distribution were identified between patients and controls. When patients were stratified according to gender, response to treatment, age at onset, no significant differences were observed. Neither allele A (Ser), or G (Gly) were preferentially transmitted from parents to affected offspring.
  
  
  CONCLUSIONS
  The hypothesis that the DRD3 Ser9Gly polymorphism plays a predisposing role in schizophrenia is not supported by this study.
authors: Douglas Hospital Research Centre, Montréal University, Québec, Canada. ferid.fathalli@douglas.mcgill.ca
authors: Ferid
authors: F
authors: Fathalli
authors: Guy A
authors: GA
authors: Rouleau
authors: Lan
authors: L
authors: Xiong
authors: Karim
authors: K
authors: Tabbane
authors: Chawki
authors: C
authors: Benkelfat
authors: Rosherrie
authors: R
authors: Deguzman
authors: Danics
authors: D
authors: Zoltan
authors: Samarthji
authors: S
authors: Lal
authors: Sarogini
authors: S
authors: D'cruz
authors: Ridha
authors: R
authors: Joober
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005190:Family; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D005998:Glycine / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012694:Serine / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: D014150:Antipsychotic Agents; C493593:DRD3 protein, human; D005819:Genetic Markers; D050637:Receptors, Dopamine D3; D012694:Serine; D005998:Glycine