The common biology of cancer and ageing.
At first glance, cancer and ageing would seem to be unlikely bedfellows. Yet the origins for this improbable union can actually be traced back to a sequence of tragic--and some say unethical--events that unfolded more than half a century ago. Here we review the series of key observations that has led to a complex but growing convergence between our understanding of the biology of ageing and the mechanisms that underlie cancer.
Finkel
Toren
T
Cardiology Branch, NIH, NHLBI, Building 10/CRC 5-3330, 10 Center Drive, Bethesda, Maryland 20892, USA. finkelt@nih.gov
Serrano
Manuel
M
Blasco
Maria A
MA
D000818:Animals; D001343:Autophagy; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology*; D042822:Genomic Instability / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000201:enzymology / Q000235:genetics / Q000378:metabolism
D019098:Telomerase