The effects of interventions on health-related quality of life among persons with diabetes: a systematic review.
BACKGROUND
Health-related quality of life (HRQL) is increasingly used to measure the outcomes of interventions among people with chronic diseases.


OBJECTIVE
To assess the effect of interventions for adults with diabetes on HRQL, as measured by the Short Form (SF)-36 questionnaire.


METHODS
The systematic review was conducted using the methods of the Cochrane Collaboration. Studies reporting SF-36 scores before and after an intervention focused on adults with diabetes were obtained from searches of multiple bibliographic databases. The mean changes and standardized mean differences between pre- and post-intervention were reported as outcome measures. Pooled estimates were obtained using random effects models.


RESULTS
: We identified 33 studies examining a wide range of interventions, including diabetes education and behavioral modifications (15 studies), pharmacotherapy (11 studies), and surgery (7 studies). Interventions generally demonstrated improvement in HRQL. When all available profile scores were examined together, the ranges of mean changes in scores were as follows: surgery for treating diabetes comorbidities, 15.0 to 42.0 point improvement; surgery for treating diabetes complications, -13.0 to 37.9; pharmacotherapy using insulin to optimize glycemic control, -4.6 to 27.6; pharmacotherapy for treating comorbidities, 3.8 to 33.2; pharmacotherapy for treating complications, -2.6 to 14.6. Pooled effects from 5 randomized controlled trials of educational interventions demonstrated significantly improved physical function [3.4 (95% CI, 0.1-6.6)] and mental health [4.2 (95% CI, 1.8-6.6)], and a decrease in bodily pain [3.6 (95% CI, 0.6-6.7)].


CONCLUSIONS
A variety of interventions can improve HRQL among adults with diabetes, but the magnitude of effects varied with the interventions. The mechanism of these changes needs to be further examined in the future research.
Zhang
Xuanping
X
Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. xbz2@cdc.gov
Norris
Susan L
SL
Chowdhury
Farah M
FM
Gregg
Edward W
EW
Zhang
Ping
P
D000328:Adult; D016206:Databases, Bibliographic; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D019317:Evidence-Based Medicine; D006266:Health Education / Q000458:organization & administration*; D006801:Humans; D017063:Outcome Assessment, Health Care; D011788:Quality of Life; D018434:Sickness Impact Profile