title: Relationships between myocardial injury, all-cause mortality, vitamin D, PTH, and biochemical bone turnover markers in older patients with hip fractures.
abstract: This study examined the relationships between myocardial injury as indicated by serum cardiac troponin I (cTnI) elevation, 25 hydroxyvitamin D [25(OH)D], and PTH status and biochemical markers of bone metabolism in older patients with hip fracture (HF). In 238 consecutive patients (mean age 81.9 +/- 7.8 yr; 72% women) with low trauma HF, serum concentrations of cTnI, 25(OH)D, PTH, calcium, phosphorus, magnesium, osteocalcin, bone-specific alkaline phosphatase (BAP), and urine excretion of free deoxypyridinoline (DPD) and N-terminal cross-linked teleopeptide of type I collagen (NTx) were measured and clinical data were collected prospectively. Myocardial injury (cTnI >0.06 microg/L) presented in 29%, 25(OH)D deficiency (<50 nmol/L) in 81.6%, elevated PTH (>6.5 pmol/L) in 53%, and excessive bone resorption (increased DPD and/or NTx excretion) in 93.7%. Multivariate logistic regression showed that elevated serum PTH level is a major predictor of peri-operative myocardial injury (OR = 2.13; 95% CI 1.01-4.51; p = 0.049) and in-hospital all-cause mortality (OR = 18.5; 95% CI 2.0-72.3; p = 0.010), independent of age, sex, 25(OH)D status, and comorbidities. The degree of hyperparathyroidism was associated with the risk of cTnI elevation and the mortality rate. In cTnI positive patients, PTH levels correlated with cTnI concentrations (r = 0.28; p = 0.026) and urine DPD exretion (r = 0.37; p = 0.004). These results suggest for the first time that in older patients with HF, elevated PTH level is associated with peri-operative myocardial injury and in-hospital all-cause mortality, and that elevated PTH level contributes to both disturbed bone metabolism and poor outcomes.
authors: Department of Geriatric Medicine, The Canberra Hospital, Yamba Drive, Garran, ACT, Australia. alex.fisher@act.gov.au
authors: Alexander A
authors: AA
authors: Fisher
authors: Emma K
authors: EK
authors: Southcott
authors: Wichat
authors: W
authors: Srikusalanukul
authors: Michael W
authors: MW
authors: Davis
authors: Peter E
authors: PE
authors: Hickman
authors: Julia M
authors: JM
authors: Potter
authors: Paul N
authors: PN
authors: Smith
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000378:metabolism*; D016723:Bone Remodeling / Q000502:physiology*; D024042:Collagen Type I / Q000652:urine; D005260:Female; D006620:Hip Fractures / Q000097:blood* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000401:mortality; D010281:Parathyroid Hormone / Q000097:blood*; D010455:Peptides / Q000652:urine; D015996:Survival Rate; D019210:Troponin I / Q000097:blood*; D014807:Vitamin D / Q000097:blood*
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D010281:Parathyroid Hormone; D010455:Peptides; D019210:Troponin I; C052929:collagen type I trimeric cross-linked peptide; D014807:Vitamin D; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase