Identification and molecular characterization of multiple phenotypes in integrin knockout mice.
Each of the 24 known integrin subunits has now been inactivated in mice, and a growing number of conditional null lines are becoming available. Lines of mice expressing null mutations in integrin subunit genes have taught us a great deal about the remarkably diverse functions that integrins perform in vivo in mammals. Thorough evaluation of the phenotypes manifested by these lines has also revealed a number of previously unexpected integrin ligands and signaling partners. In this article, we review approaches that can contribute to optimal use of this valuable resource.
Chen
Chun
C
Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Sheppard
Dean
D
D000818:Animals; D016023:Integrins / Q000145:classification / Q000235:genetics* / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008967:Molecular Biology / Q000379:methods; D010641:Phenotype
D016023:Integrins