[Visceral morphofunctional changes in guinea-pigs during long-term administration of antituberculous agents].
Antituberculous drugs (ATD) can adversely affect the kidney and liver. Visceral morphological and histochemical changes were studied in guinea-pigs long receiving a combination of 2 or 5 ATDs. The use of ATDs caused changes at all levels (organ, tissue, and cell). The liver exhibited a pattern of microvesicular steatosis and the kidneys showed hyaline dropwise degeneration. The activity of NADN-DH, NADRH-GH, lactate dehydrogenase, glucose-6-phosphate dehydrogenase lowered in the liver and kidneys, so did the activity of acid phosphatase in the alveolar macrophages. More pronounced changes were detected after the use of 5 ATDs.
Vol'f
S B
SB
Lis
R E
RE
Vinogradova
L E
LE
Shinkevich
O N
ON
D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005234:Fatty Liver / Q000139:chemically induced* / Q000473:pathology; D005500:Follow-Up Studies; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D012307:Risk Factors; D013997:Time Factors
D000995:Antitubercular Agents