title: Seasonal and biological variations of Epidendrum mosenii: quantification of 24-methylenecycloartanol using gas chromatography.
abstract: Epidendrum mosenii is a Brazilian medicinal plant, traditionally used to treat infective and dolorous processes. The present article reports a comparative study of the chemical and pharmacological aspects of different parts and seasons of this plant. The results demonstrate that 24-methylenecycloartanol (1), one of the main active principles present in this plant, is located practically in all the parts and during all seasons, but it is much more concentrated in the stems when collected in spring and summer. The pharmacological results indicate that dichloromethane extracts collected in spring and summer were the most active when evaluated against the writhing test in mice, being several times more potent than some reference drugs used as comparison. Together, the results strongly suggest that the antinociceptive effect of E. mosenii is related, at least in part, to the presence of compound 1, and this finding could be useful for quality control of phytopreparations based on this plant.
authors: Núcleo de Investigações Químico-Farmacêuticas e Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Itajaí, SC, Brazil.
authors: Patricia Walter
authors: PW
authors: Rosa
authors: Marina da Silva
authors: Mda S
authors: Machado
authors: Fátima
authors: F
authors: de Campos-Buzzi
authors: Rivaldo
authors: R
authors: Niero
authors: Franco
authors: F
authors: Delle Monache
authors: Valdir
authors: V
authors: Cechinel Filho
mesh_terms: D000700:Analgesics / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D001938:Brazil; D002849:Chromatography, Gas; D051379:Mice; D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry* / Q000254:growth & development; D010840:Phytosterols / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry* / Q000254:growth & development; D012621:Seasons
chemical_list: D000700:Analgesics; D010840:Phytosterols; C066041:24-methylene cycloartanol