Small angle scattering and zeta potential of liposomes loaded with octa(carboranyl)porphyrazine.
In this work, the physicochemical characterization of liposomes loaded with a newly synthesized carboranyl porphyrazine (H2HECASPz) is described. This molecule represents a potential drug for different anticancer therapies, such as boron neutron capture therapy and for photodynamic therapy or photothermal therapy. Different loading methods and different lipid mixtures were tested. The corresponding loaded vectors were studied by small angle scattering, light scattering, and zeta potential. The combined analysis of structural data at various lengths of scales and the measurement of the surface charge allowed us to obtain a detailed characterization of the investigated systems. The mechanisms underlying the onset of differences in relevant physicochemical parameters (size, polydispersity, and charge) were also critically discussed.
Salvati
Anna
A
University of Firenze, Department of Chemistry, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, Laboratoire des Colloïdes, Verres et Nanomatériaux (LCVN), Université Montpellier II, 34095 Montpellier Cedex 05 France.
Ristori
Sandra
S
Oberdisse
Julian
J
Spalla
Olivier
O
Ricciardi
Giampaolo
G
Pietrangeli
Daniela
D
Giustini
Mauro
M
Martini
Giacomo
G
D005229:Fatty Acids, Monounsaturated / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry; D011719:Pyrazines / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction
D005229:Fatty Acids, Monounsaturated; D008081:Liposomes; D010713:Phosphatidylcholines; D011719:Pyrazines; D000644:Quaternary Ammonium Compounds; C017251:1,2-oleoylphosphatidylcholine; C070046:1,2-dioleoyloxy-3-(trimethylammonium)propane