Mechanisms involved in the cerebrovascular dilator effects of N-methyl-d-aspartate in cerebral cortex.
Glutamate and its synthetic analogues N-methyl-d-aspartate (NMDA), kainate, and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) are potent dilator agents in the cerebral circulation. The close linkage between neural activity-based release and actions of glutamate on neurons and the related decrease in cerebral vascular resistance is a classic example in support of the concept of tight coupling between increased neural activity and cerebral blood flow. However, mechanisms involved in promoting cerebral vasodilator responses to glutamatergic agents are controversial. Here we review the development and current status of this important field of research especially in respect to cerebrovascular responses to NMDA receptor activation.
Busija
David W
DW
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157-1010, USA. dbusija@wfubmc.edu
Bari
Ferenc
F
Domoki
Ferenc
F
Louis
Thomas
T
D000818:Animals; D002536:Cerebral Arteries / Q000187:drug effects / Q000378:metabolism*; D002540:Cerebral Cortex / Q000098:blood supply* / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D013181:Cortical Spreading Depression / Q000187:drug effects / Q000502:physiology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D016202:N-Methylaspartate / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists / Q000378:metabolism; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D018690:Excitatory Amino Acid Agonists; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D016202:N-Methylaspartate
J Neurosci Res. 1994 Jun 15;38(3):314-8
7523688
Circ Res. 2004 Nov 12;95(10):e73-81
15499024
Stroke. 1995 Nov;26(11):2172-5; discussion 2176
7482668
Brain Res. 1995 Dec 15;704(1):61-70
8750962
Cell Mol Life Sci. 2000 Oct;57(11):1535-41
11092448
Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1459-65
15191891
Circ Res. 1990 Mar;66(3):824-31
2306808
Am J Physiol. 1997 Apr;272(4 Pt 2):H1785-90
9139963
Neuroscience. 1994 Feb;58(4):785-91
8190255
Nat Neurosci. 2006 Nov;9(11):1397-1403
17013381
Brain Res. 1997 Mar 7;750(1-2):25-40
9098526
Circ Res. 1993 Feb;72(2):476-80
8380361
Brain Res. 1997 Apr 18;754(1-2):35-45
9134957
Brain Res. 1994 Aug 22;654(2):349-51
7987685
J Neurophysiol. 2005 Dec;94(6):4121-30
16162834
Nat Neurosci. 2003 Jan;6(1):43-50
12469126
Am J Physiol. 1996 Apr;270(4 Pt 2):H1225-30
8967360
Brain Res. 2006 Jan 19;1069(1):39-46
16388784
Am J Physiol. 1993 Jul;265(1 Pt 2):H389-94
8342656
J Cereb Blood Flow Metab. 2003 Feb;23(2):190-7
12571450
Am J Physiol. 1988 Aug;255(2 Pt 2):H343-6
3136668
Am J Physiol. 1997 Sep;273(3 Pt 2):H1166-76
9321803
Am J Physiol. 1999 Dec;277(6 Pt 2):R1760-70
10600924
J Neurosci. 2007 Mar 7;27(10):2468-71
17344384
Am J Physiol. 1995 Jul;269(1 Pt 2):H23-9
7631852
Brain Res Brain Res Rev. 1990 Jan-Apr;15(1):41-70
2163714
Am J Physiol. 1995 Oct;269(4 Pt 2):H1297-302
7485561
Stroke. 1994 Dec;25(12):2463-70
7526490
Trends Neurosci. 2002 Jul;25(7):359-64
12079764
Brain Res. 1994 Mar 21;640(1-2):93-7
8004468
Pediatr Res. 1999 Jun;45(6):834-7
10367774
Neurotox Res. 2005 Nov;8(3-4):221-5
16371316
Nature. 2004 Sep 9;431(7005):195-9
15356633
Am J Physiol. 1994 Mar;266(3 Pt 2):H1095-102
7512795
Novartis Found Symp. 2006;276:208-17; discussion 217-21, 233-7, 275-81
16805432
Am J Physiol. 1996 Sep;271(3 Pt 2):H990-5
8853333
J Neurosci. 2006 Mar 15;26(11):2862-70
16540563
J Neurosci. 2001 May 1;21(9):3045-51
11312289
Trends Neurosci. 1997 Jan;20(1):9-12
9004411
J Comp Neurol. 2000 May 15;420(4):445-65
10805920
Brain Res. 1997 Feb 7;747(2):259-72
9046001
Brain Res. 2003 Jul 25;979(1-2):98-103
12850576
Brain Res Bull. 2004 Mar 15;63(2):127-31
15130701
Am J Physiol. 1994 Jul;267(1 Pt 2):R34-7
8048641
Nat Rev Neurosci. 2006 Jan;7(1):41-53
16371949
Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1837-41
16299263
Neuroreport. 2003 Feb 10;14(2):201-3
12598729
Stroke. 1995 Nov;26(11):2097-101; discussion 2102
7482657
Brain Res. 1987 Feb 17;403(2):243-8
3828821
Exp Brain Res. 2003 Jan;148(2):256-60
12520415
Pharmacol Rev. 2005 Jun;57(2):173-85
15914466
Am J Physiol Cell Physiol. 2006 May;290(5):C1399-410
16371440
J Physiol. 1890 Jan;11(1-2):85-158.17
16991945
J Neurotrauma. 2001 Jun;18(6):615-23
11437084
Stroke. 1997 Apr;28(4):850-6; discussion 856-7
9099207
Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2897-904
16891404
Microvasc Res. 2005 Jul;70(1-2):76-83
15975610
Neurochem Res. 1997 Jun;22(6):705-11
9178954
Stroke. 1998 Apr;29(4):837-42; discussion 842-3
9550520
Am J Physiol. 1989 Oct;257(4 Pt 2):H1200-3
2572176
Am J Physiol Cell Physiol. 2001 Dec;281(6):C1954-63
11698254
Anesth Analg. 1996 Feb;82(2):264-8
8561325
Brain. 1994 Feb;117 ( Pt 1):199-210
7908596
J Comp Neurol. 2000 May 29;421(2):161-71
10813779
Neuroscience. 1999;92(1):47-60
10392829
Am J Physiol. 1996 Dec;271(6 Pt 2):R1568-75
8997354
Neuroreport. 2000 Jul 14;11(10):2103-6
10923652
Circ Res. 2005 Dec 9;97(12):e104-14
16293786
Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R728-35
16601261
Stroke. 1996 Sep;27(9):1634-9; discussion 1639-40
8784141
Neuron. 1999 Oct;24(2):461-9
10571239
Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1893-9
15576430
Neuroscience. 1996 Jun;72(4):1133-40
8735235
Am J Physiol. 1997 Mar;272(3 Pt 2):H1315-22
9087607
Radiology. 1998 Jul;208(1):73-9
9646795
Am J Physiol Heart Circ Physiol. 2001 Jan;280(1):H160-7
11123230
Nat Rev Neurosci. 2005 Jan;6(1):77-85
15611729
J Appl Physiol (1985). 2006 Jan;100(1):307-17
16357084
Am J Physiol Heart Circ Physiol. 2000 Nov;279(5):H2188-95
11045952
J Neurosci. 2006 Mar 8;26(10):2673-83
16525046
Am J Physiol. 1987 Oct;253(4 Pt 2):H869-73
3661735
Prostaglandins. 1996 Mar;51(3):203-13
8848550
Brain Res. 1996 Aug 19;730(1-2):193-8
8883903
Brain Res. 1990 Oct 22;530(2):267-74
2265358
Brain Res Mol Brain Res. 2002 Jul 15;104(1):66-80
12117552
Alcohol Clin Exp Res. 2005 Mar;29(3):430-6
15770119
Am J Physiol. 1994 Jan;266(1 Pt 2):R158-63
8304537
J Comp Neurol. 1996 Mar 25;367(1):1-9
8867279
Angiology. 1969 Oct;20(9):535-62
5824355
Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1442-7
15964921
Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2371-6
12003848
J Neurosci. 2004 Oct 13;24(41):8940-9
15483113
Am J Physiol. 1995 Jul;269(1 Pt 2):H215-21
7631851
J Cereb Blood Flow Metab. 1992 Mar;12(2):223-9
1312539
Neurotoxicology. 2004 Sep;25(5):835-47
15288514
J Neurochem. 1989 Dec;53(6):1952-4
2553870
Neuroreport. 1998 Feb 16;9(3):415-8
9512382
Neuroreport. 2001 Dec 21;12(18):4065-8
11742239
Brain Res. 2002 Oct 4;951(2):177-82
12270495
J Neurosci Res. 2004 Jun 1;76(5):697-704
15139028
Brain Res. 1992 Jan 31;571(1):97-102
1351777
Brain Res. 2002 Feb 22;928(1-2):40-9
11844470
Am J Physiol Heart Circ Physiol. 2000 Oct;279(4):H1616-24
11009448
Brain Res. 1996 Oct 21;737(1-2):339-42
8930388
Stroke. 1994 Oct;25(10):2080-3; discussion 2084
8091455
Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1404-9
11893577
Acta Physiol Scand. 1989 Jul;136(3):483-5
2546374
J Neurosci Methods. 1995 Aug;60(1-2):165-73
8544476
Stroke. 1999 Jan;30(1):148-52
9880403
Circ Res. 1985 Nov;57(5):689-94
4053302
Am J Physiol Heart Circ Physiol. 2003 May;284(5):H1631-7
12543638
Stroke. 1999 Dec;30(12):2713-8; discussion 2718-9
10583002
J Cereb Blood Flow Metab. 1998 Apr;18(4):396-406
9538905
Mol Pharmacol. 1999 Dec;56(6):1207-18
10570048
Brain Res. 1989 Mar 20;482(2):393-6
2565145
Brain Res. 1998 Jan 12;780(2):237-44
9507150
Stroke. 1997 Jun;28(6):1272-6; discussion 1277
9183361
Trends Neurosci. 1991 Feb;14(2):60-7
1708538
Stroke. 1995 May;26(5):857-62; discussion 863
7740580
Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1073-9
12666665
J Cereb Blood Flow Metab. 2007 Mar;27(3):575-87
16896350
J Appl Physiol (1985). 2006 Mar;100(3):1065-76
16467393