Genome-wide association studies provide new insights into type 2 diabetes aetiology.
Human geneticists are currently in the middle of a race. Thanks to a new technology in the form of 'genome-wide chips', investigators can potentially find many novel disease genes in one large experiment. Type 2 diabetes has been hot out of the blocks with six recent publications that together provide convincing evidence for six new gene regions involved in the condition. Together with candidate approaches, these studies have identified 11 confirmed genomic regions that alter the risk of type 2 diabetes in the European population. One of these regions, the fat mass and obesity associated gene (FTO), represents by far the best example of an association between common variation and fat mass in the general population.
Frayling
Timothy M
TM
Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula Medical School, University of Exeter, Exeter EX1 2LV, UK. tim.frayling@pms.ac.uk
D000818:Animals; D015992:Body Mass Index; D002874:Chromosome Mapping; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000235:genetics*; D020869:Gene Expression Profiling; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D009765:Obesity / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis