title: Eradication of unusual pathogens by combination pharmacological therapy is paralleled by improvement of signs and symptoms of chronic prostatitis syndrome.
abstract: We performed a comparative analysis of microbiological and clinical responses to combination therapy in 104 symptomatic patients showing evidence of infection by traditional uropathogens (TU) or by unusual pathogens (UP) at the prostatic level. Eighty-two pathogens out of a total of 104 isolated microorganisms were eradicated at the end of a 6-week course of combination therapy with ciprofloxacin, azithromycin, alfuzosin and a S. repens extract. The TU and UP groups showed eradication rates of 75.5% and 82.3%, and clinical success rates of 78.8% and 85.7%, respectively. Thus, a similar response to therapy was observed in patients infected by TU or by UP. Intergroup differences were not significantly different, with the exception of higher scores relative to the impact of the disease on quality of life in TU-patients. Long-term improvement of signs and symptoms of prostatitis indicates that combination therapy is beneficial for symptomatic patients showing evidence of infection by unusual pathogens at the prostatic level. Our data support the hypothesis that organisms other than the traditionally recognized uropathogens may play a role in the onset of prostatitis.
authors: Urology and Sonography Outpatient Clinic, Istituti Clinici di Perfezionamento, Milan, Italy.
authors: Vittorio
authors: V
authors: Magri
authors: Alberto
authors: A
authors: Trinchieri
authors: Isabella
authors: I
authors: Ceriani
authors: Emanuela
authors: E
authors: Marras
authors: Gianpaolo
authors: G
authors: Perletti
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000328:Adult; D000726:Androgen Antagonists / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D017963:Azithromycin / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002939:Ciprofloxacin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use; D011472:Prostatitis / Q000188:drug therapy* / Q000382:microbiology; D011799:Quinazolines / Q000627:therapeutic use; D028024:Serenoa; D016896:Treatment Outcome
chemical_list: D000317:Adrenergic alpha-Antagonists; D000726:Androgen Antagonists; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010936:Plant Extracts; D011799:Quinazolines; D002939:Ciprofloxacin; D017963:Azithromycin; C047638:alfuzosin; C040972:saw palmetto extract