title: [Activity and penetration of linezolid and vancomycin against Staphylococcus epidermidis biofilms].
abstract: BACKGROUND
  The activity and capacity for penetration of linezolid and vancomycin were comparatively evaluated against Staphylococcus epidermidis biofilms.
  
  
  METHODS
  The activity of linezolid versus vancomycin was assessed against 24-hour S. epidermidis biofilms developed on silicon catheters. Penetration of the two antimicrobial agents was measured in biofilms developed on polycarbonate membrane filters. Penetration and activity were comparatively tested using S. epidermidis, slime-producing and non-slime-producing strains.
  
  
  RESULTS
  The activity of linezolid against S. epidermidis biofilms was significantly greater than that of vancomycin for both strains. Neither antimicrobial completely eradicated bacterial survival in 24-hour biofilms. Linezolid penetration in biofilms was greater than that of vancomycin for both S. epidermidis strains.
  
  
  CONCLUSIONS
  Linezolid showed higher in vitro activity than vancomycin against S. epidermidis biofilms on silicone catheters. This effect may be due to the capability of linezolid to cross the bacterial biofilm.
authors: Departamento de Microbiología, Universidad de Sevilla, España. jmrodriguez@us.es
authors: José M
authors: JM
authors: Rodríguez-Martínez
authors: Sofía
authors: S
authors: Ballesta
authors: Isabel
authors: I
authors: García
authors: M Carmen
authors: MC
authors: Conejo
authors: Alvaro
authors: A
authors: Pascual
mesh_terms: D000081:Acetamides / Q000493:pharmacokinetics / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D016667:Bacterial Capsules / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects*; D002404:Catheterization; D024881:Drug Resistance, Bacterial; D004866:Equipment Contamination; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000493:pharmacokinetics / Q000494:pharmacology*; D010539:Permeability; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis; D012828:Silicones; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000378:metabolism; D014640:Vancomycin / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D011135:Polysaccharides, Bacterial; D012828:Silicones; D014640:Vancomycin; D000069349:Linezolid