Diguanylate cyclase activation: it takes two.
Characterization of an activated diguanylate cyclase reported in this issue of Structure by Wassmann et al. (2007) reveals how phosphorylation promotes dimerization necessary for synthesis of the second messenger c-di-GMP, establishes the catalytic mechanism, and identifies a widely conserved mode of product inhibition.
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Ann M
AM
D002384:Catalysis; D019281:Dimerization; D004789:Enzyme Activation; D029968:Escherichia coli Proteins; D008954:Models, Biological; D019761:Phosphorus-Oxygen Lyases / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D015290:Second Messenger Systems
D029968:Escherichia coli Proteins; D019761:Phosphorus-Oxygen Lyases; C060720:diguanylate cyclase