title: Interleukin-12 and tuberculosis: an old story revisited.
abstract: Our understanding of the role of interleukin (IL)-12 in controlling tuberculosis has expanded because of increased interest in other members of the IL-12 family of cytokines. Recent data show that IL-12, IL-23 and IL-27 have specific roles in the initiation, expansion and control of the cellular response to tuberculosis. Specifically, IL-12, and to a lesser degree IL-23, generates protective cellular responses and promotes survival, whereas IL-27 moderates the inflammatory response and is required for long-term survival. Paradoxically, IL-27 also limits bacterial control, suggesting that a balance between bacterial killing and tissue damage is required for survival. Understanding the balance between IL-12, IL-23 and IL-27 is crucial to the development of immune intervention in tuberculosis.
authors: The Trudeau Institute, Inc. 154 Algonquin Ave. Saranac Lake, NY 12983, USA. acooper@trudeauinstitute.org
authors: Andrea M
authors: AM
authors: Cooper
authors: Alejandra
authors: A
authors: Solache
authors: Shabaana A
authors: SA
authors: Khader
mesh_terms: D000818:Animals; D002908:Chronic Disease; D006801:Humans; D007111:Immunity, Cellular; D018664:Interleukin-12 / Q000276:immunology / Q000378:metabolism*; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism*; D053759:Interleukin-23 / Q000276:immunology / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23; D018664:Interleukin-12
references: Infect Immun. 2004 Apr;72(4):2400-4
references: 15039368
references: J Immunol. 2003 Jan 1;170(1):597-603
references: 12496448
references: J Exp Med. 2005 Dec 19;202(12):1649-58
references: 16352737
references: Mol Ther. 2004 Jun;9(6):895-901
references: 15194056
references: J Exp Med. 2006 Jul 10;203(7):1805-15
references: 16818672
references: J Med Genet. 2007 Feb;44(2):e65
references: 17293536
references: J Immunol. 2005 Jul 15;175(2):788-95
references: 16002675
references: J Clin Invest. 2004 Dec;114(12):1790-9
references: 15599404
references: Vaccine. 2006 Feb 20;24(8):1191-204
references: 16216394
references: Trends Immunol. 2007 Jan;28(1):33-8
references: 17126601
references: Immunity. 2006 Feb;24(2):179-89
references: 16473830
references: Immunity. 2003 Nov;19(5):641-4
references: 14614851
references: J Immunol. 2006 Aug 1;177(3):1416-20
references: 16849446
references: J Immunol. 2006 Oct 1;177(7):4662-9
references: 16982905
references: Eur J Pediatr. 2005 Mar;164(3):166-72
references: 15633050
references: Infect Immun. 1997 Feb;65(2):623-9
references: 9009322
references: J Biol Chem. 2005 Dec 30;280(52):42794-800
references: 16263713
references: J Mol Med (Berl). 2007 Jul;85(7):661-72
references: 17294231
references: Infect Immun. 2005 Sep;73(9):5782-8
references: 16113296
references: Nat Immunol. 2006 Sep;7(9):929-36
references: 16906167
references: J Immunol. 2005 Mar 15;174(6):3534-44
references: 15749890
references: Infect Immun. 2006 Nov;74(11):6092-9
references: 16923792
references: J Immunol. 2006 Dec 15;177(12):8684-92
references: 17142769
references: Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8427-32
references: 10890924
references: Nat Immunol. 2006 Sep;7(9):937-45
references: 16906166
references: Infect Immun. 2006 Aug;74(8):4954-9
references: 16861689
references: Semin Immunol. 2006 Dec;18(6):347-61
references: 16997570
references: J Immunol. 1997 Feb 1;158(3):1217-21
references: 9013962
references: Am J Pathol. 2006 Jan;168(1):158-69
references: 16400019
references: J Exp Med. 2006 Jul 10;203(7):1745-59
references: 16818673
references: J Immunol. 2002 Feb 1;168(3):1322-7
references: 11801672
references: J Exp Med. 2005 Dec 19;202(12):1715-24
references: 16365150
references: J Immunol. 2006 Jul 1;177(1):422-9
references: 16785538
references: Vaccine. 2006 Feb 27;24(9):1315-23
references: 16219397
references: Nat Immunol. 2006 Nov;7(11):1151-6
references: 16998492
references: J Immunol. 2005 Apr 1;174(7):4185-92
references: 15778379
references: J Clin Invest. 2005 Jun;115(6):1601-6
references: 15931391
references: Blood. 2007 Jun 1;109(11):4846-55
references: 17289816
references: J Immunol. 2007 Mar 15;178(6):3786-96
references: 17339477
references: J Exp Med. 2002 Nov 4;196(9):1253-62
references: 12417634
references: Eur J Immunol. 2004 Nov;34(11):3276-84
references: 15384045
references: J Immunol. 2001 Dec 15;167(12):6957-66
references: 11739515
references: J Immunol. 2004 Dec 15;173(12):7490-6
references: 15585875
references: Nat Immunol. 2007 Apr;8(4):369-77
references: 17351619
references: J Immunol. 2006 Aug 1;177(3):1618-27
references: 16849470
references: Infect Immun. 2006 Jan;74(1):557-65
references: 16369012