Effect of n-propylthiouracil or thyroxine on arsenic trioxide toxicity in the liver of rat.
Involvement of thyroid gland in the hepatotoxic manifestations of arsenic trioxide (As(III)) has been studied in rat. The effects of n-propylthiouracil (PTU) (a thyrotoxic compound) and L-thyroxine (a thyroid hormone) have been studied with reference to T(3) and T(4) values in the serum, arsenic concentration in the liver, Ca(2+) accumulation in the liver, aspartate transaminase, alanine transaminase and bilirubin values as the indicators of liver function, histopathological observations and finally the ultrastructural studies. It is concluded that hypothyroid condition protects against As(III) toxicity. Scavenging of reactive oxygen species (ROS) that significantly contribute in As(III) toxicity, by high intracellular concentration of reduced glutathione, as a consequence of PTU treatment is proposed as the plausible protective mechanism.
Allen
Tanu
T
Department of Zoology, Toxicology Laboratory, Ch. Charan Singh University, Meerut, India.
Rana
Suresh Vir  Singh
SV
D000818:Animals; D020261:Arsenic Poisoning / Q000473:pathology*; D000077237:Arsenic Trioxide; D001152:Arsenicals; D002118:Calcium / Q000378:metabolism; D006980:Hyperthyroidism / Q000139:chemically induced / Q000150:complications; D007037:Hypothyroidism / Q000139:chemically induced / Q000150:complications / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010087:Oxides / Q000633:toxicity*; D011441:Propylthiouracil / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000473:pathology / Q000648:ultrastructure; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology*; D014284:Triiodothyronine / Q000097:blood
D001152:Arsenicals; D010087:Oxides; D014284:Triiodothyronine; D011441:Propylthiouracil; D013974:Thyroxine; D000077237:Arsenic Trioxide; D002118:Calcium