Innate immune evasion by hepatitis C virus and West Nile virus.
Antiviral immunity in mammals involves several levels of surveillance and effector actions by host factors to detect viral pathogens, trigger alpha/beta interferon production, and to mediate innate defenses within infected cells. Our studies have focused on understanding how these processes are regulated during infection by hepatitis C virus (HCV) and West Nile virus (WNV). Both viruses are members of the Flaviviridae and are human pathogens, but they each mediate a very different disease and course of infection. Our results demonstrate common and unique innate immune interactions of each virus that govern antiviral immunity and demonstrate the central role of alpha/beta interferon immune defenses in controlling the outcome of infection.
Keller
Brian C
BC
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Johnson
Cynthia L
CL
Erickson
Andrea Kaup
AK
Gale
Michael
M
D000818:Animals; D016174:Hepacivirus / Q000472:pathogenicity*; D006801:Humans; D007113:Immunity, Innate; D007372:Interferons / Q000276:immunology*; D014902:West Nile virus / Q000472:pathogenicity*
D007372:Interferons
Nature. 2005 Aug 18;436(7053):967-72
16107837
Lab Invest. 2004 Sep;84(9):1148-59
15208644
Science. 2005 Jul 22;309(5734):581-5
15961631
J Immunol. 2005 Sep 1;175(5):2851-8
16116171
Emerg Infect Dis. 2005 Apr;11(4):629-32
15829208
J Virol. 2002 Dec;76(24):13001-14
12438626
Nat Immunol. 2005 Oct;6(10):981-8
16127453
J Immunol. 2005 Oct 15;175(8):5260-8
16210631
Nature. 2005 Aug 18;436(7053):939-45
16107833
Sci STKE. 2004 Nov 23;2004(260):tr10
15561979
Antivir Chem Chemother. 2004 Mar;15(2):101-9
15185728
Gastroenterology. 2005 May;128(5):1437-44
15887125
Trends Immunol. 2006 Jan;27(1):1-4
16309964
J Virol. 2006 Mar;80(6):2913-23
16501100
Curr Opin Immunol. 2007 Feb;19(1):17-23
17118636
Virology. 2005 Nov 10;342(1):119-40
16125213
Annu Rev Microbiol. 2002;56:371-402
12142476
Lancet Infect Dis. 2002 Sep;2(9):519-29
12206968
Immunity. 2005 Jul;23(1):19-28
16039576
Eur J Clin Microbiol Infect Dis. 2004 Mar;23(3):147-56
14986160
J Virol. 2003 Apr;77(7):3898-912
12634350
Nature. 1959 Oct 17;184(Suppl 16):1232-3
13853042
Science. 2003 May 16;300(5622):1145-8
12702807
Hepatology. 2003 Dec;38(6):1458-67
14647057
Nat Rev Immunol. 2002 Sep;2(9):675-87
12209136
J Virol. 2004 Jul;78(14):7737-47
15220448
Clin Liver Dis. 2006 Nov;10(4):697-715
17164113
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):582-7
17190814
Clin Liver Dis. 2006 Nov;10(4):919-40
17164125
Science. 1999 Dec 17;286(5448):2333-7
10600742
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2986-91
15710892
IUBMB Life. 2006 Sep;58(9):508-14
17002978
J Virol. 2006 Mar;80(5):2396-404
16474146
J Virol. 2006 Oct;80(19):9424-34
16973548
J Virol. 2006 Jul;80(14):7009-19
16809306
J Virol. 2005 Nov;79(21):13350-61
16227257
Hepatology. 2003 May;37(5):1180-8
12717400
J Virol. 2002 Jun;76(11):5532-9
11991981
J Virol. 2005 Jul;79(13):8004-13
15956546
Gastroenterology. 2006 Nov;131(5):1584-91
17101330
J Immunol. 2015 Sep 1;195(5):1911-20
26297790
Oncogene. 2004 Mar 4;23(9):1789-800
14676839
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15669-74
12441396
Nat Immunol. 2004 Jul;5(7):730-7
15208624
J Virol. 2001 Sep;75(18):8516-23
11507197
J Virol. 2006 Oct;80(19):9349-60
16973541
RNA. 2004 Sep;10(9):1337-51
15273323
J Biol Chem. 2007 Apr 6;282(14):10792-803
17289677
J Virol. 2006 Dec;80(24):12332-42
17020950
Lancet Infect Dis. 2005 Sep;5(9):558-67
16122679
J Virol. 2007 Jan;81(2):860-71
17079283
Nature. 2006 May 4;441(7089):101-5
16625202
J Virol. 2005 Feb;79(3):1343-50
15650160
J Virol. 2005 Mar;79(5):2689-99
15708988
Science. 2006 Nov 10;314(5801):994-7
17038590
Nat Rev Drug Discov. 2002 Nov;1(11):867-81
12415247
Clin Infect Dis. 2005 Mar 1;40(5):764-6
15714427
Nature. 2005 Oct 20;437(7062):1167-72
16177806
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):6001-6
16585524
Annu Rev Microbiol. 2001;55:255-81
11544356
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4650-5
11904369
Nature. 2005 Aug 18;436(7053):933-8
16107832