title: Clinicopathologic significance in serum presence of anti-p53 antibody in patients with colorectal carcinoma.
abstract: OBJECTIVE
  Alteration of p53 gene links to the appearance and detection of anti-p53 antibodies in the serum. The aim of this study is to find the clinicopathologic significance for serum presence of anti-p53 antibodies in patients with colorectal carcinoma.
  
  
  METHODS
  Serum presence of anti-p53 antibodies was examined for sera of 36 patients with colorectal carcinoma using enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Frequency of serum presence of anti-p53 antibodies was 47.2% (17 of 36). Incidence of lymph node metastasis and lymphatic invasion in tumors coexisting with serum presence of anti-p53 antibodies (70.6%, 12 of 17 and 94.1%, 16 of 17) were significantly higher than those in tumors without serum presence of anti-p53 antibodies (17.6%, 3 of 17 and 68.4%, 13 of 19; p = 0.007 and p = 0.041, respectively). Stages of the tumors were significantly more advanced in carcinomas coexisting with serum presence of anti-p53 antibodies (p = 0.023). Frequency in serum presence of anti-p53 antibodies among patients with tumors expressing p53 (73.7%, 14 of 19) was significantly higher than that among patients with tumors without p53 expression (17.6%, 3 of 17; p = 0.0005).
  
  
  CONCLUSIONS
  Preoperative serum appearance of anti-53 antibodies can be an indicator for more malignant potential of colorectal carcinoma.
authors: Department of General Surgery, Fukuoka Dental College Hospital Kyushu University 2-15-1, Tamura, Sawara Ward, Fukuoka, 814-0193, Japan. ntvb@med.uoeh-u.ac.jp
authors: Tadahiro
authors: T
authors: Nozoe
authors: Mitsuhiro
authors: M
authors: Yasuda
authors: Masayuki
authors: M
authors: Honda
authors: Sadaaki
authors: S
authors: Inutsuka
authors: Daisuke
authors: D
authors: Korenaga
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D016159:Tumor Suppressor Protein p53