title: WSPM: wavelet-based statistical parametric mapping.
abstract: Recently, we have introduced an integrated framework that combines wavelet-based processing with statistical testing in the spatial domain. In this paper, we propose two important enhancements of the framework. First, we revisit the underlying paradigm; i.e., that the effect of the wavelet processing can be considered as an adaptive denoising step to "improve" the parameter map, followed by a statistical detection procedure that takes into account the non-linear processing of the data. With an appropriate modification of the framework, we show that it is possible to reduce the spatial bias of the method with respect to the best linear estimate, providing conservative results that are closer to the original data. Second, we propose an extension of our earlier technique that compensates for the lack of shift-invariance of the wavelet transform. We demonstrate experimentally that both enhancements have a positive effect on performance. In particular, we present a reproducibility study for multi-session data that compares WSPM against SPM with different amounts of smoothing. The full approach is available as a toolbox, named WSPM, for the SPM2 software; it takes advantage of multiple options and features of SPM such as the general linear model.
authors: Biomedical Imaging Group, Ecole Polytechnique Fédérale de Lausanne (EPFL), and Department of Radiology and Medical Informatics, University Hospital Geneva, Switzerland. Dimitri.VanDeVille@epfl.ch
authors: Dimitri
authors: D
authors: Van De Ville
authors: Mohamed L
authors: ML
authors: Seghier
authors: François
authors: F
authors: Lazeyras
authors: Thierry
authors: T
authors: Blu
authors: Michael
authors: M
authors: Unser
mesh_terms: D000161:Acoustic Stimulation; D000465:Algorithms; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000706:statistics & numerical data*; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D017711:Nonlinear Dynamics; D012372:ROC Curve; D015203:Reproducibility of Results