title: Three different synchronous primary lung tumours: a case report with extensive genetic analysis and review of the literature.
abstract: Synchronous triple lung tumours are rare and little is known as for their genetic basis. Here we report a case of a 59 years old male with three synchronous independent and histological different primary tumours of the left lung. Two nodules were located in the upper lobe and consisted of an adenocarcinoma (ADC) and an endobronchial poorly differentiated squamous cell carcinoma (SCC). A third nodule of the lower lobe corresponded to a small cell neuroendocrine carcinoma (SCLC). To assess if they represented independent primary tumours and have common genetic profiles, tumours were investigated for loss of heterozygosity (LOH) at 40 chromosomal markers. A comparable fractional allelic loss of 0.52 was observed in the ADC and SCLC, while it was 0.28 in the SCC. Microallelotyping analysis did not reveal a common genetic profile, supporting the hypothesis that the three synchronous tumours are truly independent primaries with different histogenesis.
authors: Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, Parma, Italy.
authors: Elisabetta
authors: E
authors: Froio
authors: Tiziana
authors: T
authors: D'Adda
authors: Giovanni
authors: G
authors: Fellegara
authors: Luca
authors: L
authors: Ampollini
authors: Paolo
authors: P
authors: Carbognani
authors: Guido
authors: G
authors: Rindi
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D018278:Carcinoma, Neuroendocrine / Q000235:genetics / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology; D006801:Humans; D019656:Loss of Heterozygosity; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology*; D016133:Polymerase Chain Reaction