Distribution of insulin-like growth factors in condylar hyperplasia.
Condylar hyperplasia (CH) is a local overgrowth of the condylar process of the temporomandibular joint (TMJ) of unknown etiology. Probably, growth factors like the insulin-like growth factors (IGFs) are involved in its pathogenesis. Specimens from 12 patients were investigated histologically and immunohistochemically to obtain the distribution of the IGFs-I and -II and the IGF1 receptor. The results revealed juvenile and adult subtypes. While generally IGF-II could only be detected weakly, in the juvenile cases strong immunostaining for IGF-I in cartilage and bone supposes an influence on pathological growth processes.
Götz
Werner
W
Zentrum für Zahn-, Mund- und Kieferheilkunde, Poliklinik für Kieferorthopddie, Oralbiologische Grundlagenforschung, Welschnonnenstrsse 17, D-53111 Bonn, Germany. wgoetz@uni-bonn.de
Lehmann
Tim Sebastian
TS
Appel
Thorsten Robin
TR
Rath-Deschner
Birgit
B
Dettmeyer
Reinhard
R
Luder
Hans-Ulrich
HU
Reich
Rudolf H
RH
Jäger
Andreas
A
D000328:Adult; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008297:Male; D008335:Mandibular Condyle / Q000473:pathology*; D008875:Middle Aged; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D013705:Temporomandibular Joint Disorders / Q000378:metabolism / Q000473:pathology*
D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D017526:Receptor, IGF Type 1