title: Highly efficient synthesis of functionalized indolizines and indolizinones by copper-catalyzed cycloisomerizations of propargylic pyridines.
abstract: The copper-catalyzed cycloisomerizations of 2-pyridyl-substituted propargylic acetates and its derivatives are described, which offer an efficient route to C-1 oxygenated indolizines with a wide range of substituents under mild reaction conditions. The presented method could be readily applied to the synthesis of indolizinones through a cyclization/1,2-migration of tertiary propargylic alcohols.
authors: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China.
authors: Bin
authors: B
authors: Yan
authors: Yebing
authors: Y
authors: Zhou
authors: Hao
authors: H
authors: Zhang
authors: Jingjin
authors: J
authors: Chen
authors: Yuanhong
authors: Y
authors: Liu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D007212:Indolizines / Q000138:chemical synthesis*; D007536:Isomerism; D020005:Propanols / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007212:Indolizines; D020005:Propanols; D011725:Pyridines; D003300:Copper; C028255:propargyl alcohol