Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk.
An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD.
Rodríguez-Rodríguez
Eloy
E
Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
Infante
Jon
J
Llorca
Javier
J
Mateo
Ignacio
I
Sánchez-Quintana
Coro
C
García-Gorostiaga
Inés
I
Sánchez-Juan
Pascual
P
Berciano
José
J
Combarros
Onofre
O
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D015994:Incidence; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010750:Phosphoproteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins; D011506:Proteins; C513637:WWC1 protein, human