The anti-cancer effects of quinolone antibiotics?
A previous meta-analysis showed that quinolones administered for prophylaxis of infections among cancer patients reduced all-cause mortality. We extracted from the primary trials infection-related and all-cause mortality as reported and assessed the effect of quinolones on non-infection-related mortality through meta-analysis. Among trials comparing quinolones to placebo or no treatment, a significant reduction in non-infection-related mortality was observed (relative risk 0.54, 95% confidence interval 0.32-0.93, 15 trials, 3,320 patients). This finding might represent biased attribution of deaths to infection or might be compatible with an anti-cancer effect of quinolone antibiotics. We present further analyses addressing these possibilities.
Paul
M
M
Department of Medicine E and Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, 49100, Israel. pil1pel@zahav.net.il
Gafter-Gvili
A
A
Fraser
A
A
Leibovici
L
L
D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D015363:Quinolones / Q000627:therapeutic use*
D000903:Antibiotics, Antineoplastic; D015363:Quinolones
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