title: Risk factors for the development of cataract requiring surgery in uveitis associated with juvenile idiopathic arthritis.
abstract: OBJECTIVE
  To identify the possible risk factors for the development of cataract requiring surgery in children with juvenile idiopathic arthritis (JIA)-associated uveitis.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Data of 53 children with JIA-associated uveitis, of whom 27 had undergone cataract extraction (CE), were obtained. The main outcome measure, the interval between the onset of uveitis and the first CE (U-CE interval), was examined in relation to clinical and ophthalmologic characteristics and treatment strategies before CE.
  
  
  RESULTS
  A shorter U-CE interval was found for children with posterior synechia vs those without posterior synechia (hazard ratio [HR], 3.57; 95% confidence interval [CI], 1.33 to 10.00). No significant difference was found for children in whom the uveitis was the first manifestation of JIA vs those in whom arthritis was the first manifestation of JIA (HR, 1.59; 95% CI, 0.63 to 4.00) and children treated with periocular corticosteroid injections vs those not treated with periocular corticosteroid injections (HR, 3.23; 95% CI, 0.95 to 11.11). Children treated with methotrexate (MTX) had a longer U-CE interval than children not treated with MTX (HR, 0.29; 95% CI, 0.10 to 0.87).
  
  
  CONCLUSIONS
  The risk factor for development of early cataract requiring surgery in children with JIA-associated uveitis is the presence of posterior synechia at the time of diagnosis of uveitis. However, early treatment with MTX is associated with a mean delay in the development of cataract requiring surgery of 3.5 years.
authors: FC Donders Institute of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands. K.Sijssens@umcutrecht.nl
authors: Karen M
authors: KM
authors: Sijssens
authors: Aniki
authors: A
authors: Rothova
authors: David A M C
authors: DA
authors: Van De Vijver
authors: Jan S
authors: JS
authors: Stilma
authors: Joke H
authors: JH
authors: De Boer
mesh_terms: D017668:Age of Onset; D001171:Arthritis, Juvenile / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002386:Cataract / Q000209:etiology* / Q000628:therapy; D002387:Cataract Extraction; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents