Antidyslipidemic activity of polyprenol from Coccinia grandis in high-fat diet-fed hamster model.
Ethanol extract of Coccinia grandis (L.) Voigt showed significant triglyceride (TG) and cholesterol-lowering effects in dyslipidemic hamster model. Ethanolic extract was fractionated into chloroform, n-butanol and water-soluble fractions and were evaluated. Activity was proved to be concentrated in chloroform-soluble fraction. Chloroform-soluble fraction containing active component was subjected to repeated column chromatography, furnished a polyprenol characterized as C(60)-polyprenol (1) isolated for the first time from this plant. It significantly decreased serum TG by 42%, total cholesterol (TC) 25% and glycerol (Gly) 12%, accompanied HDL-C/TC ratio 26% in high-fat diet (HFD)-fed dyslipidemic hamsters at the dose of 50mg/kg body weight. Results are comparable to standard drug fenofibrate at the dose of 108 mg/kg. Based on these investigations, it was concluded that the compound polyprenol (1) isolated from leaves of C. grandis possess marked antidyslipidemic activity.
Singh
Geetu
G
Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India.
Gupta
Prasoon
P
Rawat
Preeti
P
Puri
Anju
A
Bhatia
Gitika
G
Maurya
Rakesh
R
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D019662:Cucurbitaceae / Q000737:chemistry*; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy*; D045782:Hemiterpenes; D009682:Magnetic Resonance Spectroscopy; D008647:Mesocricetus; D000439:Pentanols / Q000627:therapeutic use*
D004041:Dietary Fats; D045782:Hemiterpenes; D000439:Pentanols; C009034:prenol