title: Indirect estimation of pediatric Health Related Limits for serum thyrotropin using the ADVIA Centaur analyzer.
abstract: OBJECTIVE
  To determine pediatric reference values for thyrotropin using Advia Centaur analyzer.
  
  
  METHODS
  The study was conducted in a large regional hospital on TSH results obtained from 5741 females and 4332 males aged 0-17 years. After the exclusion of the results outside 4 standard deviations, we calculated the Health Related Limits (HRLs) following the indirect Kairisto's procedure and using the software GraphROC.
  
  
  RESULTS
  The lower HRL of TSH concentration was 0.70 mU/L in the years 0-11 and 0.50 mU/L in the following years. The upper TSH HRL was 6.9 mU/L in males vs. 5.7 mU/L in females in the first year and 6.7 mU/L vs. 5.3 in the period 1-2 years. The upper HRLs in females and males were similar in the following years and the upper HRL in the 13-17 years class was 3.8 mU/L.
  
  
  CONCLUSIONS
  The indirect methods appear reliable for calculating the pediatric HRLs for TSH.
authors: Laboratorio di Chimica clinica ed Ematologia, Ospedale S.Bortolo, Vicenza, Italy.
authors: Davide
authors: D
authors: Giavarina
authors: Romolo M
authors: RM
authors: Dorizzi
authors: Antonio
authors: A
authors: Fortunato
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D003940:Diagnostic Techniques, Endocrine / Q000295:instrumentation* / Q000592:standards*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012016:Reference Values; D012727:Sex Characteristics; D013223:Statistics as Topic; D013972:Thyrotropin / Q000032:analysis* / Q000097:blood*
chemical_list: D013972:Thyrotropin