Anthracycline-based combined chemotherapy in the mouse model.
Our research was aimed at establishing if and how selenium (Se) ion, N-acetylcysteine (NAC), sodium salt of monoketocholic acid (MKH) and superoxide-dismutase (SOD), administered in the experimental animal model, could affect the possible cytotoxicity associated with anthracycline-based combined chemotherapy with doxorubicin, vincristine and prednisolone (DVP). The following biochemical parameters were investigated: the extent of lipid peroxidation (LPx), and the activity of peroxidase (Px), catalase (CAT), glutathione-peroxidase (GSHPx), and xanthine-oxidase (XOD). A statistical increase in LPx activity was obtained by SOD, MKH, DVPSe and DVPMKH. All chemotherapeutic agents reduced Px activity in a statistically significant manner. There was no statistical significance for the results regarding the effects of the administered substances on GSHPx activity. The results for DVP, SOD, MKH, DVPSOD, DVPSe and DVPMKH showed reduced XOD activity which was statistically significant, which was lowest in the case of MKH, while NAC and Se reduced the activity of this enzyme but statistically non significant. NAC, Se, DVP, MKH and DVPMKH caused a reduction in CAT activity, while DVPSOD and DVPSe caused an increase of the latter.
Popovic
M
M
Faculty of Sciences, Department of Chemistry, University of Novi Sad, Republic of Serbia.
Kolarovic
J
J
Mikov
M
M
Trivic
S
S
Kaurinovic
B
B
D000111:Acetylcysteine / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D018943:Anthracyclines / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology; D002374:Catalase / Q000187:drug effects; D002793:Cholic Acids / Q000494:pharmacology; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004347:Drug Interactions; D016166:Free Radical Scavengers / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009195:Peroxidase / Q000187:drug effects; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D012643:Selenium / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000494:pharmacology; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects; D014969:Xanthine Oxidase / Q000187:drug effects
D018943:Anthracyclines; D000975:Antioxidants; D002793:Cholic Acids; D016166:Free Radical Scavengers; D014750:Vincristine; D004317:Doxorubicin; D011239:Prednisolone; D002374:Catalase; D009195:Peroxidase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D012643:Selenium; D000111:Acetylcysteine
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