title: [Relationship between ureaplasma urealyticum infection and ectopic pregnancy].
abstract: OBJECTIVE
  To explore the relationship between different subtypes of Ureaplasma Urealyticum infection and ectopic pregnancy.
  
  
  METHODS
  Ectopic pregnancy group included 33 patients and another 40 patients undergoing salpingo-ovariectomy with ovarian cyst or uterine myoma were investigated as control group. Polymerase chain reaction technique was used to detect Uu DNA in the two groups samples from endosalpinx and secretion of cervix. At the same time, these samples were set to electron microscope for examination.
  
  
  RESULTS
  (1) Uu was detected in 27 fallopian tubal epithelium tissues among 33 ectopic pregnancy samples (81.8%), in which biovar1 was positive in 17 samples (52%, 17/33), biovar 2 was positive in 15 (46%, 15/33) and both biovar 1 and 2 positive was 5 (15.2%). While in the control group, Uu was detected in 24 fallopian tubal epithelium tissues among 40 samples (60%), in which biovar1 was positive in 21 samples (52%, 21/40), biovar 2 was positive in 5 (12%, 5/40) and both biovar 1 and 2 positive was 2 (5%). There was no significant difference between the two groups in Uu of biovar 1 (P > 0.05). The positive rate of Uu in biovar 2 show a significant difference (P < 0.05). (2) Co-expression samples in both fallopian tubal epithelium and cervical mucus samples from ectopic pregnancy patients in biovar1 was 13 (72.2%), and in biovar 2 was 11 (71.4%). While in control group, co-expression samples in both fallopian tubal epithelium and cervical mucus samples in biovar 1 was 18 (81.8%), and in biovar 2 was 5 (71.4%). There was no significant difference between the two groups in co-expression in both fallopian tubal epithelium and cervical mucus samples (P > 0.05). (2) The fallopian tubes infected by biovar 2 have a high rate (90%) of ciliary adhesion and exuviation. While there is a low rate (10%) for biovar1 with ciliary adhesion and exuviation. There was significant difference between the two groups of Uu (P < 0.05).
  
  
  CONCLUSIONS
  The infection of ureaplasma urealyticum may increase the occurrence of fallopian pregnancy. The infection of ureaplasma urealyticum may be concerned with the morphological changes and functional damage of uterine fallopian epithelium.
authors: Department of Obstetrics and Gynecology, People's Hospital of Beijing University, Beijing 100044, China.
authors: Xu-Dong
authors: XD
authors: Liang
authors: Ting-Ting
authors: TT
authors: Gu
authors: Jian-Liu
authors: JL
authors: Wang
authors: Heng
authors: H
authors: Cui
authors: Li-Hui
authors: LH
authors: Wei
mesh_terms: D000328:Adult; D002582:Cervix Mucus / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D004848:Epithelium / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure; D005187:Fallopian Tubes / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008855:Microscopy, Electron, Scanning; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D011271:Pregnancy, Ectopic / Q000382:microbiology*; D016869:Ureaplasma Infections / Q000382:microbiology*; D016990:Ureaplasma urealyticum / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D004269:DNA, Bacterial