Rapid development of an osteosarcoma after surgical resection of an osteochondroma.
The rapid development of an osteosarcoma, after surgical resection of an osteochondroma, has not been yet reported. We present here the case of a 12-year-old girl that had, in less than 2 months, an osteosarcoma at the initial site of a treated osteochondroma. Comparative Genomic Hybridization analyses showed that the 2 tumors were genetically distinct, suggesting a distant, if any, relationship. The possible implication of a deregulated tissue homeostasis caused by the surgical intervention is discussed. Proangiogenic factors involved in the tissue healing could be the triggering factor favoring tumor angiogenesis and explaining the very rapid progression of the tumor.
Gomez-Brouchet
Anne
A
Centre Hospitalier Universitaire, Hôpital des Enfants, Toulouse 3, France.
Accadbled
Franck
F
Rubie
Herve
H
Janka
Dora
D
Castex
Marie-Pierre
MP
Thuille
Benedicte
B
Delattre
Olivier
O
Laurell
Henrick
H
Baunin
Christiane
C
de Gauzy
Jérôme Sales
JS
D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology*; D002648:Child; D018450:Disease Progression; D005260:Female; D015894:Genome, Human; D006801:Humans; D009389:Neovascularization, Pathologic; D009693:Nucleic Acid Hybridization; D015831:Osteochondroma / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography