title: Predictive value of neurodevelopmental assessment versus evaluation of general movements for motor outcome in preterm infants with birth weights <1500 g.
abstract: OBJECTIVE
  The aim of this study was to make a comparison of predictive values of neurodevelopmental assessment and evaluation of videotaped spontaneous movements of premature infants for motor outcome.
  
  
  METHODS
  We performed a prospective longitudinal study of 103 VLBW infants, 96 (455-1490 g, 24-35 weeks gestational age) including (a) a neurodevelopmental assessment based on criteria by Amiel-Tison/Grenier at 40 weeks postconceptional age, 3 and 20 months corrected age; (b) an evaluation of general movements with fidgety character, based on criteria by Prechtl, at 3 months; and (c) a standardized testing using the Griffiths Developmental Motor Scale at 20 months. We calculated sensitivity, specificity and predictive values for each method.
  
  
  RESULTS
  For predicting motor outcome, the assessment of general movements (GM) had a positive predictive value of 89% and negative predictive value of 84%; neurodevelopmental assessment (NA) at 40 weeks had a positive predictive value of 33% and negative predictive value of 88%, respectively, with similar results for neurodevelopmental assessment at age 3 months.
  
  
  CONCLUSIONS
  Normal motor outcome of VLBW infants may be accurately predicted by clinical neurodevelopmental assessment, but for adverse outcomes, evaluation of general movements (fidgety movements) is superior. GM assessment has a high predictive value, especially for CP, but it needs to be complemented by NA for non-CP outcomes. It is a simple, repeatable and non-intrusive technique, and may be a valuable method for the early detection of central nervous system impairment in VLBW infants in routine follow-up.
authors: University Lübeck, Children and Adolescents Medical Center, Lübeck, Germany.
authors: N
authors: N
authors: Stahlmann
authors: C
authors: C
authors: Härtel
authors: A
authors: A
authors: Knopp
authors: B
authors: B
authors: Gehring
authors: H
authors: H
authors: Kiecksee
authors: U
authors: U
authors: Thyen
mesh_terms: D002657:Child Development / Q000502:physiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D019102:Infant, Very Low Birth Weight; D008137:Longitudinal Studies; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D019957:Motor Skills Disorders / Q000175:diagnosis*; D010808:Physical Examination; D011237:Predictive Value of Tests; D012720:Severity of Illness Index