title: Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk.
abstract: An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD.
authors: Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors: Eloy
authors: E
authors: Rodríguez-Rodríguez
authors: Jon
authors: J
authors: Infante
authors: Javier
authors: J
authors: Llorca
authors: Ignacio
authors: I
authors: Mateo
authors: Coro
authors: C
authors: Sánchez-Quintana
authors: Inés
authors: I
authors: García-Gorostiaga
authors: Pascual
authors: P
authors: Sánchez-Juan
authors: José
authors: J
authors: Berciano
authors: Onofre
authors: O
authors: Combarros
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D015994:Incidence; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010750:Phosphoproteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins; D011506:Proteins; C513637:WWC1 protein, human