Clinical investigation of the transient evoked otoacoustic emission test in Crimean-Congo hemorrhagic fever.
OBJECTIVE
The aim of this study was to investigate cochlear damage in Crimean-Congo hemorrhagic fever (CCHF) infection.


METHODS
Thirty-two CCHF patients (study group) and 13 healthy people (controls) were included in the study. CCHF patients were also grouped for the presence of fever. CCHF was diagnosed with the presence of CCHF virus-specific IgM antibody or CCHF virus (CCHFV) antigen by ELISA. Cochlear damage was determined by a 'fail' in the transient evoked otoacoustic emission (TEOAE) test.


RESULTS
The proportion of TEOAE test 'fail' results in the CCHF patients was significantly higher than in the control group (p<0.05). We found no increase in the proportion of TEOAE test 'fail' results related to fever in the study group.


CONCLUSIONS
CCHF disease damages cochlear function regardless of fever.
Engin
Aynur
A
Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University School of Medicine, Sivas 58140, Turkey. enginay@cumhuriyet.edu.tr
Yildirim
Altan
A
Kunt
Tanfer
T
Bakir
Mehmet
M
Dokmetas
Ilyas
I
Ozdemir
Levent
L
D000328:Adult; D003051:Cochlea / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000821:virology*; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000302:isolation & purification; D006479:Hemorrhagic Fever, Crimean / Q000150:complications* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous; D011446:Prospective Studies; D014421:Turkey