title: [Evaluation of left ventricular function in patients with chronic obstructive pulmonary disease].
abstract: BACKGROUND
  Patients with right ventricle (RV) pressure overload often have impaired left ventricular (LV) diastolic function. Objectives. The aim of study was to evaluate LV function in patients with chronic obstructive pulmonary disease (COPD). Patients and methods. Thirty-five patients (mean age: 62.1 +/- 7.7 y) with COPD without additional cardiac diseases and 25 age--and sex-matched healthy subjects were enrolled into the study. All patients underwent resting ECG tracing, blood pressure, spirometry, standard and tissue Doppler echocardiography.
  
  
  RESULTS
  The mean value of forced expiratory volume in one second (FEV1) in the COPD group was 40 +/- 8.9% of the predicted value. We found no significant differences in LV end-diastolic and systolic diameter and interventricular septum as well between COPD patients and controls. RV end-diastolic diameter and RV wall thickness were significantly larger and right ventricle systolic pressure--RVSP (38 +/- 11.2 vs. 20 +/- 2.5 mm Hg) significantly higher in the COPD group. Both peak early to peak atrial filling velocities ratio--E/A and peak annular velocity during early diastole to peak annular velocity during atrial contraction--Em/Am were significantly lower in COPD compared to controls. Moreover, there was a strong inverse correlation between Em/Am and RVSP (r = -0.75; p < 0.001) and between E/A (r = -0.6; p < 0.001) as well. We found no significant differences in parameters assessing the LV systolic function between both groups.
  
  
  CONCLUSIONS
  In COPD patients LV diastolic function is significantly impaired and its magnitude is related with increase in pulmonary artery pressure, while systolic LV function is well preserved.
authors: Odział Kliniczny Chorób Serca i Naczyń, Collegium Medicum Uniwersytetu Jagiellońskiego i Krakowski Szpital Specjalistyczny im. Jana Pawła II, Kraków. esuchon@szpitaljp2.krakow.pl
authors: Elzbieta
authors: E
authors: Suchoń
authors: Wiesława
authors: W
authors: Tracz
authors: Piotr
authors: P
authors: Podolec
authors: Monika
authors: M
authors: Pieculewicz
authors: Wojciech
authors: W
authors: Płazak
authors: Anna
authors: A
authors: Prokop
authors: Piotr
authors: P
authors: Nalepa
mesh_terms: D000368:Aged; D001794:Blood Pressure; D016022:Case-Control Studies; D003971:Diastole; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right