Dicer finds a new partner in transcriptional gene silencing.
In a recent study in Molecular Cell, Colmenares et al. (2007) showed that fission yeast Dicer is physically and functionally associated with RNA-dependent RNA polymerase complex (RDRC), revealing a concerted mechanism in transcriptional gene silencing.
Shiekhattar
Ramin
R
Center for Genomic Regulation, C/Dr. Aiguader, 88, 08003, Barcelona, Spain. ramin.shiekhattar@crg.es
D000251:Adenosine Triphosphatases / Q000378:metabolism; D002384:Catalysis; D006801:Humans; D011485:Protein Binding; D034622:RNA Interference; D012331:RNA, Fungal / Q000378:metabolism; D043244:Ribonuclease III / Q000737:chemistry / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000201:enzymology*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism
D012331:RNA, Fungal; D029702:Schizosaccharomyces pombe Proteins; D043244:Ribonuclease III; D000251:Adenosine Triphosphatases; C416926:Rdp1 protein, S pombe