Myeloid-derived suppressor cells.
The development of tumor-specific T cell tolerance is largely responsible for tumor escape. Accumulation of myeloid-derived suppressor cells (MDSCs) in animal tumor models as well as in cancer patients is involved in tumor-associated T cell tolerance. In recent years, it has become increasingly evident that MDSCs bring about antigen-specific T cell tolerance by various mechanisms, which is the focus of this chapter.
Nagaraj
Srinivas
S
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA.
Gabrilovich
Dmitry I
DI
D000818:Animals; D000941:Antigens / Q000378:metabolism; D001120:Arginine / Q000737:chemistry; D002454:Cell Differentiation; D000939:Epitopes / Q000737:chemistry; D006801:Humans; D007108:Immune Tolerance; D008954:Models, Biological; D022423:Myeloid Cells / Q000166:cytology*; D009369:Neoplasms / Q000276:immunology; D030421:Peroxynitrous Acid / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000166:cytology; D016212:Transforming Growth Factor beta / Q000378:metabolism
D000941:Antigens; D000939:Epitopes; D017382:Reactive Oxygen Species; D016212:Transforming Growth Factor beta; D030421:Peroxynitrous Acid; D001120:Arginine