title: Intracardiac thrombosis and acute right ventricular failure following complex reoperative cardiac surgery with aprotinin and deep hypothermic circulatory arrest.
abstract: Although coagulopathy and bleeding are common in the setting of cardiac surgery, a growing number of case reports in the literature suggest that hypercoagulability may also result in significant morbidity and mortality. We present a case of apparent hypercoagulability with formation of thrombus in the cardiac chambers following reoperative cardiac surgery using cardiopulmonary bypass, aprotinin, and deep hypothermic arrest. A review of those hypercoagulable disorders with reported impact on cardiac surgery and a discussion follow the case presentation.
authors: Mount Sinai School of Medicine, New York, New York 10029-6574, USA. marc.stone@mountsinai.org
authors: Marc E
authors: ME
authors: Stone
authors: Scott H
authors: SH
authors: Silverman
authors: Koichi
authors: K
authors: Nomoto
mesh_terms: D000368:Aged; D001018:Aortic Diseases / Q000150:complications / Q000601:surgery; D007611:Aprotinin / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D050792:Circulatory Arrest, Deep Hypothermia Induced; D003324:Coronary Artery Disease / Q000150:complications / Q000601:surgery; D003328:Coronary Thrombosis / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000601:surgery; D011183:Postoperative Complications / Q000503:physiopathology*; D012086:Reoperation; D019851:Thrombophilia / Q000097:blood / Q000150:complications; D014262:Tricuspid Valve Insufficiency / Q000150:complications / Q000601:surgery; D018497:Ventricular Dysfunction, Right / Q000209:etiology* / Q000503:physiopathology
chemical_list: D006490:Hemostatics; D007611:Aprotinin