title: Evaluation of the effect of Dardia Lipo Line on skin inflammation induced by surfactants using the repeated open-application test.
abstract: BACKGROUND
  Medical skin care products are topical preparations with mainly moisturizing properties. A new line of medical skin products with an excellent tolerability profile and improved hydration for dry skin has been developed, but beneficial effects have not yet been investigated on damaged skin.
  
  
  OBJECTIVE
  To investigate if these products maintain barrier function and hydration status, improve subjective symptoms due to irritant contact dermatitis and to prove their tolerability on damaged skin.
  
  
  METHODS
  Single-centre, blinded, randomized, controlled study in 20 healthy Caucasian women. 5% sodium lauryl sulphate solution was used to induce skin irritation. Two sites on the inside surface of both forearms of each subject were treated daily for 5 days (irritation period). Lipo Cream, Lipo Milk (water-in-oil emulsions) and Lipo Ointment (water-free formulation) were applied twice daily to three of the four test sites on days 1-5. The fourth site was used as a control. Visual readings, subjective symptom assessments, transepidermal water loss (TEWL) and colorimetric measurements, corneometry and skin microrelief macrophotographies were done on days 1-6.
  
  
  RESULTS
  On day 6, TEWL was increased vs baseline on all sites; however, TEWL with Lipo Cream or Lipo Ointment was significantly lower than control. At day 6, skin capacitance was 94%, 100% and 85% of baseline value for the cream, milk and ointment, respectively, versus 72% for control. All test products were well tolerated.
  
  
  CONCLUSIONS
  Lipo Line products showed both protective properties against epidermal dysfunction and significant hydrating effect.
authors: Department of Dermatology, Hôpital l'Archet 2, Nice, France. ortonne@unice.fr
authors: J-P
authors: JP
authors: Ortonne
authors: C
authors: C
authors: Queille-Roussel
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003872:Dermatitis / Q000188:drug therapy* / Q000209:etiology; D004655:Emulsions / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009824:Ointments / Q000008:administration & dosage / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D004655:Emulsions; D009824:Ointments