title: Recent Korean isolates of duck hepatitis virus reveal the presence of a new geno- and serotype when compared to duck hepatitis virus type 1 type strains.
abstract: Duck hepatitis was first reported in 1985 in Korea. The complete nucleotide sequence of two past Korean isolates, DHV-HS and DHV-HSS, isolated in 1994 and 1995, and four recent Korean isolates, AP-03337, AP-04009, AP-04114 and AP-04203 isolated in 2003 and 2004, were determined. Phylogenetic analysis using the 3D protein sequence confirmed that the previously characterized duck hepatitis virus type 1 strains and the six Korean isolates described here constitute a monophyletic group and form two clades/genotypes in which all except the four recent Korean isolates form one group (A) and the recent Korean isolates of 2003 and 2004 constitute a second group (B). Phylogenetic analysis of the VP1 protein supported the division into two different groups. Antisera raised against viruses of group A showed significant neutralizing cross-reaction against a member of the same genotype but not to a strain of group B and vice versa. These results demonstrated that the two genotypes also could be regarded as two different serotypes.
authors: National Veterinary Research and Quarantine Service, Anyang, Republic of Korea.
authors: M-C
authors: MC
authors: Kim
authors: Y-K
authors: YK
authors: Kwon
authors: S-J
authors: SJ
authors: Joh
authors: S-J
authors: SJ
authors: Kim
authors: C
authors: C
authors: Tolf
authors: J-H
authors: JH
authors: Kim
authors: H-W
authors: HW
authors: Sung
authors: A M
authors: AM
authors: Lindberg
authors: J-H
authors: JH
authors: Kwon
mesh_terms: D000818:Animals; D001483:Base Sequence; D005838:Genotype; D004371:Hepatitis Virus, Duck / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006524:Hepatitis, Viral, Animal / Q000821:virology*; D007723:Korea; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D010802:Phylogeny; D010850:Picornaviridae Infections / Q000662:veterinary* / Q000821:virology; D017422:Sequence Analysis, DNA; D012703:Serotyping; D013045:Species Specificity