Successful pregnancy with the use of nitric oxide donors and heparin after recurrent severe preeclampsia in a woman with scleroderma.
We report the case of a woman with scleroderma who had severe, early-onset preeclampsia on 2 consecutive pregnancies. With a treatment that included aspirin, heparin, and a nitric oxide donor, her third pregnancy ended with a healthy neonate at term. Nitric oxide donors and heparin may play a preventive role on placental dysfunction in scleroderma.
Carbonne
Bruno
B
Department of Obstetrics and Gynecology, Hôpital Saint-Antoine, Paris, France. bruno.carbonne@sat.aphp.fr
Macé
Guillaume
G
Cynober
Evelyne
E
Milliez
Jacques
J
Cabane
Jean
J
D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D020030:Nitric Oxide Donors / Q000008:administration & dosage*; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D011248:Pregnancy Complications; D012008:Recurrence; D012595:Scleroderma, Systemic / Q000150:complications*
D006495:Heparin, Low-Molecular-Weight; D020030:Nitric Oxide Donors; D001241:Aspirin