title: Systemic and vaginal biomechanical properties of women with normal vaginal support and pelvic organ prolapse.
abstract: OBJECTIVE
  The objective of the study was to compare the biomechanical properties of vaginal and systemic skin in women with and without pelvic organ prolapse.
  
  
  METHODS
  In this cross-sectional study, 25 women with pelvic organ prolapse and 23 age-matched women with normal pelvic support were recruited from an office setting. A Cutometer MPA 580 and DermaLab skin probe were used to measure systemic biomechanical parameters and a 1.5 mm offset DermaLab skin probe was used for vaginal biomechanical measurements.
  
  
  RESULTS
  There were no significant differences in the baseline demographic, obstetrical, or gynecologic information between the 2 groups. There were no significant differences in the systemic biomechanical parameters between the 2 groups. Women with pelvic organ prolapse had significantly more extensible vaginal skin than women with normal pelvic support (initial stiffness index 7.3 vs 10.9 kpa, final stiffness index 5.9 vs 10.7 kpa; all P values less than .01). Furthermore, vaginal extensibility was related to pelvic organ prolapse quantification stage in a linear fashion.
  
  
  CONCLUSIONS
  Our findings suggest that local, rather than systemic, alterations in biomechanical skin properties are associated with pelvic organ prolapse.
authors: Louisville Pelvic Floor Research Group, Louisville, KY, USA. lepstein@urogynspecialists.com
authors: Lee B
authors: LB
authors: Epstein
authors: Carol A
authors: CA
authors: Graham
authors: Michael H
authors: MH
authors: Heit
mesh_terms: D000328:Adult; D000368:Aged; D001696:Biomechanical Phenomena; D003430:Cross-Sectional Studies; D004548:Elasticity; D005260:Female; D006801:Humans; D008875:Middle Aged; D014596:Uterine Prolapse / Q000503:physiopathology*; D014621:Vagina / Q000502:physiology*