title: Highly enantioselective Michael additions in water catalyzed by a PS-supported pyrrolidine.
abstract: The development of a highly efficient, polymer-supported organocatalyst for the Michael addition of ketones to nitroolefins is described. A 1,2,3-triazole ring, constructed through a click 1,3-cycloaddition, plays the double role of grafting the chiral pyrrolidine monomer onto the polystyrene backbone and of providing a structural element, complementary to pyrrolidine, key to high catalytic activity and enantioselectivity. Optimal operation in water and full recyclability make the triazole linker attractive for the immobilization of organocatalysts.
authors: Institute of Chemical Research of Catalonia (ICIQ), Avda. Països Catalans, 16, 43007 Tarragona, Spain.
authors: Esther
authors: E
authors: Alza
authors: Xacobe C
authors: XC
authors: Cambeiro
authors: Ciril
authors: C
authors: Jimeno
authors: Miquel A
authors: MA
authors: Pericàs