title: A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-independent mechanism.
abstract: Measles virus (MV) propagates mainly in lymphoid organs throughout the body and produces syncytia by using signaling lymphocyte activation molecule (SLAM) as a receptor. MV also spreads in SLAM-negative epithelial tissues by unknown mechanisms. Ubiquitously expressed CD46 functions as another receptor for vaccine strains of MV but not for wild-type strains. We here show that MV grows and produces syncytia efficiently in a human lung adenocarcinoma cell line via a SLAM- and CD46-independent mechanism using a novel receptor-binding site on the hemagglutinin protein. This infection model could advance our understanding of MV infection of SLAM-negative epithelial cells and tissues.
authors: Department of Virology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. mtakeda@virology.med.kyushu-u.ac.jp
authors: Makoto
authors: M
authors: Takeda
authors: Maino
authors: M
authors: Tahara
authors: Takao
authors: T
authors: Hashiguchi
authors: Takeshi A
authors: TA
authors: Sato
authors: Fumiaki
authors: F
authors: Jinnouchi
authors: Shoko
authors: S
authors: Ueki
authors: Shinji
authors: S
authors: Ohno
authors: Yusuke
authors: Y
authors: Yanagi
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis*; D002277:Carcinoma / Q000378:metabolism* / Q000821:virology*; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D004847:Epithelial Cells / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D015726:Giant Cells / Q000821:virology*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000821:virology*; D008213:Lymphocyte Activation; D008459:Measles virus / Q000378:metabolism*; D051916:Membrane Cofactor Protein / Q000096:biosynthesis*; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D015398:Signal Transduction; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D014709:Vero Cells
chemical_list: D015703:Antigens, CD; D051916:Membrane Cofactor Protein; D011956:Receptors, Cell Surface; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1
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