The effect of phase cancellation on estimates of calcaneal broadband ultrasound attenuation in vivo.
Broadband ultrasonic attenuation (BUA) is a clinically-accepted measurement for prediction of osteoporotic fracture risk. Typical clinical BUA measurements are performed with phase-sensitive receivers and, therefore, can be affected by phase cancellation. In order to separate the effects of conventional attenuation (absorption plus scattering) from phase cancellation, BUA was measured on phantoms with acrylic wedge phase aberrators and on 73 women using both phase sensitive (PS) and phase insensitive (PI) reception. A clinical bone sonometer with a two-dimensional (2-D) receiver array was used. PI BUA measurements on phantoms with acrylic wedge phase aberrators were found to be far more resistant to phase cancellation than PS BUA measurements. In data from 73 women, means and standard deviations for BUA measurements were 81.4 +/- 21.4 dB/MHz (PS) and 67.2 +/- 9.7 dB/MHz (PI). The magnitude of the discrepancy between PS BUA and PI BUA tended to increase with bone mineral density (BMD).
Wear
Keith A
KA
US Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20852, USA. keith.wear@fda.hhs.gov
D000328:Adult; D000465:Algorithms; D016477:Artifacts; D002111:Calcaneus / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000379:methods*
Lancet. 1986 Feb 8;1(8476):307-10
2868172
Bone. 2007 Jan;40(1):5-8
16949900
Osteoporos Int. 1999;9(2):99-105
10367035
Osteoporos Int. 2006 Feb;17(2):237-44
16142503
Lancet. 1996 Aug 24;348(9026):511-4
8757153
Arch Intern Med. 1997 Mar 24;157(6):629-34
9080917
J Bone Miner Res. 2002 Dec;17(12):2222-30
12469916
Bone. 2004 Aug;35(2):357-63
15268884
Osteoporos Int. 1998;8(3):211-4
9797904
Br J Radiol. 2000 Jan;73(865):31-5
10721317
Bone. 1997 Feb;20(2):157-65
9028541
J Bone Miner Res. 1995 Feb;10(2):243-9
7754803
Osteoporos Int. 1993 Jul;3(4):185-91
8338973
Osteoporos Int. 2000;11(3):189-91
10824233
Clin Phys Physiol Meas. 1989 Nov;10(4):353-60
2698780
Bone. 1998 Nov;23(5):425-31
9823448
Osteoporos Int. 1995 Mar;5(2):130-5
7599449
Lancet. 2004 Jan 17;363(9404):197-202
14738792
Bone. 1996 Jun;18(6):495-503
8805988
Calcif Tissue Int. 1999 Jan;64(1):18-23
9868278
IEEE Trans Biomed Eng. 1981 Feb;28(2):186-201
7287022
J Acoust Soc Am. 2005 Sep;118(3 Pt 1):1801-7
16240838
J Bone Miner Res. 2006 Sep;21(9):1457-63
16939404
Osteoporos Int. 1997;7(4):316-22
9373564
Osteoporos Int. 2004 Mar;15(3):217-25
14745486
J Acoust Soc Am. 2000 Jun;107(6):3474-9
10875391
J Acoust Soc Am. 1999 Dec;106(6):3659-64
10615704
Radiology. 1996 Jun;199(3):725-32
8637996
Physiol Meas. 2001 Aug;22(3):581-7
11556676
Eng Med. 1984 Apr;13(2):89-91
6540216
Bone. 2000 Jun;26(6):635-42
10831936
Br J Radiol. 1995 Nov;68(815):1212-4
8542228
Bone. 2007 Jan;40(1):9-13
16949359
Phys Med Biol. 1991 Nov;36(11):1529-37
1754623
J Acoust Soc Am. 2000 Nov;108(5 Pt 1):2403-11
11108380
Ultrasound Med Biol. 1999 Jan;25(1):133-41
10048810
Phys Med Biol. 2005 Apr 21;50(8):1629-42
15815086
Calcif Tissue Int. 1991 Aug;49(2):107-11
1913288
J Bone Miner Res. 1997 Aug;12(8):1280-8
9258759
Osteoporos Int. 2004 Mar;15(3):190-5
14727012
IEEE Trans Ultrason Ferroelectr Freq Control. 2001 Mar;48(2):602-8
11370374
J Bone Miner Res. 1997 May;12(5):839-46
9144351
J Clin Densitom. 1999 Fall;2(3):343-50
10548828
Calcif Tissue Int. 2000 May;66(5):317-9
10773098
Bone. 2005 Dec;37(6):858-63
16226929
J Acoust Soc Am. 2000 Sep;108(3 Pt 1):1281-9
11008828
J Bone Miner Res. 2003 Jul;18(7):1261-6
12854836
Med Eng Phys. 1996 Jul;18(5):373-81
8818135
J Bone Miner Res. 2004 May;19(5):782-93
15068502