title: Estimation of global and regional cardiac function using 64-slice computed tomography: a comparison study with echocardiography, gated-SPECT and cardiovascular magnetic resonance.
abstract: BACKGROUND
  Sixty-four-slice multidetector spiral computed tomography (CT) has improved temporal resolution and reduced acquisition time. We aimed to evaluate the functional analysis using 64-slice CT comparing with echocardiography, electrocardiographically gated single-photon emission tomography (SPECT) and cardiovascular magnetic resonance (CMR).
  
  
  METHODS
  Six-three patients (77.4+/-18.6 bpm) underwent 64-slice CT and CMR (echocardiography in 55; SPECT in 33) within 2 weeks were retrospectively reviewed. The left ventricular volumetric data from different methods were compared with CMR. Regional wall motion was compared between CT and CMR in a 17-segment and 4-point system (1=normal to 4=akinesis/dyskinesis).
  
  
  RESULTS
  Ejection fraction (EF), end-diastolic volume (EDV) and end-systolic volume (ESV) by CT agreed well with CMR (bias+/-SD, -0.22%+/-4.18, r=0.97;-0.59 mL+/-15.21, r=0.98; 1.09 mL+/-10.61, r=0.99) over a wide range of left ventricular (LV) function (EF 18-76% by CMR). Our results also showed good correlation of EF measured by CT and echocardiography (r=0.87) or SPECT (r=0.91, all P<0.0001); however, standard deviation of EF difference between CT and CMR was significantly less than echocardiography or SPECT (P<0.005). For regional wall motion, an exact agreement of 97% (kappa=0.91) was found between CT and CMR.
  
  
  CONCLUSIONS
  Sixty-four-slice CT agreed well with CMR in LV function assessment, and had a superior accuracy than echocardiography and SPECT on EF estimation. Sixty-four-slice CT is considered a clinically acceptable and robust method to evaluate LV function.
authors: Department of Diagnostic Imaging, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors: Yen-Wen
authors: YW
authors: Wu
authors: Eiji
authors: E
authors: Tadamura
authors: Masaki
authors: M
authors: Yamamuro
authors: Shotaro
authors: S
authors: Kanao
authors: Satoshi
authors: S
authors: Okayama
authors: Neiko
authors: N
authors: Ozasa
authors: Masanao
authors: M
authors: Toma
authors: Takeshi
authors: T
authors: Kimura
authors: Masashi
authors: M
authors: Komeda
authors: Kaori
authors: K
authors: Togashi
mesh_terms: D000465:Algorithms; D016477:Artifacts; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004452:Echocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D015899:Tomography, Emission-Computed, Single-Photon; D036542:Tomography, Spiral Computed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology*