Prevalence of viral and mycobacterial co-infections in perinatally HIV-infected children.
The progression of HIV disease may be affected by co-infection with other viruses. This study investigates the prevalence of Epstein-Barr virus (EBV); cytomegalovirus (CMV); herpes simplex virus (HSV) types 1 and 2; hepatitis A, B, and C (HA, HB, HC); and tuberculosis in perinatally HIV-infected children. Electrochemiluminescence Immunoassay (EIA) against EBV, CMV, HSV 1 and 2, HAV HBV HCV, and skin testing with purified protein derivative was performed on 45 perinatally HIV-infected children. CMVwas positive in 51%, EBVin 93.3%, HSV-1 in 62.2%, HSV-2 in 48.9%, HAV in 15.6%, HBVand HCV in 6.7% and PPD in 0%. HSV-2 prevalence was higher in females and Hispanics. The prevalence of CMV, EBV HSV-1, and tuberculosis was equivalent to rates reported in the general population. Prevalence of HSV-2 was significantly higher than in the general population (p < 0.001). Higher rates of HSV-2 infection and hepatitis may be secondary to high maternal co-infection rate and subsequent vertical transmission.
Bowser
Corinna S
CS
Allergy Immunology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.
Kaye
Jean
J
Leier
Tim U
TU
Chorney
Valeriy
V
Nathawad
Rita
R
Chernichenko
Natalya
N
Shin
Ann
A
Pragaspathy
Bhavadarani
B
Moallem
Jack
J
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000635:transmission*; D006801:Humans; D007118:Immunoassay; D018445:Infectious Disease Transmission, Vertical; D008163:Luminescent Measurements; D008297:Male; D009164:Mycobacterium Infections / Q000150:complications / Q000453:epidemiology*; D011247:Pregnancy; D015995:Prevalence; D014505:Urban Population; D014777:Virus Diseases / Q000150:complications / Q000453:epidemiology*