Synthesis of functionalised nucleosides for incorporation into nucleic acid-based serine protease mimics.
The synthesis of nucleosides modified with an extra imidazole, carboxyl and hydroxyl group is described. These nucleosides can be incorporated into an oligonucleotide duplex, thus generating a novel type of serine protease mimic.
Catry
Mieke A
MA
Ghent University, Department of Organic Chemistry, Laboratory for Organic and Biomimetic Chemistry, Krijgslaan 281 (S4), Gent, Belgium.
Madder
Annemieke
A
D002384:Catalysis; D020134:Catalytic Domain; D002918:Chymotrypsin / Q000737:chemistry / Q000378:metabolism; D006868:Hydrolysis; D007093:Imidazoles / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D018716:Molecular Mimicry; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary; D012697:Serine Endopeptidases / Q000737:chemistry* / Q000378:metabolism
D007093:Imidazoles; D009705:Nucleosides; D009841:Oligonucleotides; D010455:Peptides; C029899:imidazole; D012697:Serine Endopeptidases; D002918:Chymotrypsin; C117608:alpha-chymotrypsin
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