Plasma from women with preeclampsia has a low lipid and ketone body content--a nuclear magnetic resonance study.
OBJECTIVE
Using (1)H-nuclear magnetic resonance spectroscopy and chemometrics, we sought to establish the metabolic profile for preeclampsia and to identify biomarkers that would permit a distinction between women with a normal pregnancy and those suffering from preeclampsia.


METHODS
Plasma samples from 11 normotensive pregnant women and 11 women with preeclampsia were analyzed. Principal component analysis was applied to differentiate between the two groups of patients.


RESULTS
Lipid concentrations were found to be significantly lower in the plasma of patients suffering from preeclampsia than those in normotensive pregnant women (p = 0.031). There is also evidence to suggest that ketone body constituents may contribute to the discrimination.


CONCLUSIONS
(1)H-nuclear magnetic resonance-based metabolic profiling can detect patients with preeclampsia.
Turner
Elizabeth
E
School of Chemistry, University of Leeds, Leeds, UK.
Brewster
Jennifer A
JA
Simpson
Nigel A B
NA
Walker
James J
JJ
Fisher
Julie
J
D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007657:Ketone Bodies / Q000097:blood*; D008055:Lipids / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis; D011247:Pregnancy; D025341:Principal Component Analysis
D007657:Ketone Bodies; D008055:Lipids