The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions).
OBJECTIVE
The purpose of this study was to compare the effects of anti-adhesion materials in postoperative adhesions.


METHODS
Rats were assigned to five groups: Group 1: Control. Group 2: chitin layers were used. Group 3: Na-hyaluronate / carboxymethylcellulose layers were used. Group 4: Na-hyaluronate gel was poured into the abdomen. Group 5: methylprednisolone was injected. The adhesion frequency and grade were scored according to Granat. Blood was taken for Hb, AST, BUN and albumin levels determination.


RESULTS
The adhesion frequencies (right and left) and grades were as follow in Groups; I: 82%, 91%, 2.63 +/- 1.22; II: 8.3%, 25%, 0.58 +/- 0.66; III: 17%, 33%, 1.08 +/- 1.08; IV: 50%, 58%, 1.41 +/- 1.44; V: 50%, 42%, 1.41 +/- 1.50. The adhesion phase in all study groups was found significantly low compared to control group, p < 0.05. No difference was observed among serologic and hematological parameters in all groups.


CONCLUSIONS
All the materials used significantly lowered the adhesion frequency and grade.
Sahin
Mustafa
M
Department of General Surgery, Selcuk University Meram Medical Faculty, Konya, Turkey.
Cakir
Murat
M
Avsar
Fatih Mehmet
FM
Tekin
Ahmet
A
Kucukkartallar
Tevfik
T
Akoz
Mehmet
M
D034841:Abdominal Cavity / Q000601:surgery*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use; D002686:Chitin / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D006820:Hyaluronic Acid / Q000627:therapeutic use; D008567:Membranes, Artificial; D008775:Methylprednisolone / Q000494:pharmacology* / Q000627:therapeutic use; D010532:Peritoneal Diseases / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D000267:Tissue Adhesions; D014945:Wound Healing / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D002686:Chitin; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium; D008775:Methylprednisolone
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