Potential biochemical therapy of glioma cancer.
Glioma is a highly invasive, rapidly spreading form of brain cancer that is resistant to surgical and medical treatment. The recent progresses made in intracellular and ion channels of glioma cells provide a potential new approach for biochemical therapy of brain tumor. In this paper, we reviewed clinical data on chemotherapy by temozolomide and results from new studies on voltage-gated potassium channels, large-conductance Ca(2+)-activated K(+) channels, volume-activated chloride channels, glioma-specific chloride channel and their modulators. These new findings may represent future directions for brain tumor studies and treatment.
Yin
Li-Tian
LT
Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, PR China.
Fu
Yue-Jun
YJ
Xu
Qiao-Ling
QL
Yang
Jun
J
Liu
Zeng-Li
ZL
Liang
Ai-Hua
AH
Fan
Xiao-Jun
XJ
Xu
Cheng-Gang
CG
D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D005910:Glioma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000627:therapeutic use; D008954:Models, Biological; D015394:Molecular Structure; D026902:Potassium Channel Blockers / Q000627:therapeutic use; D024681:Potassium Channels, Calcium-Activated / Q000037:antagonists & inhibitors / Q000378:metabolism; D000077204:Temozolomide
D018906:Antineoplastic Agents, Alkylating; D007211:Indoles; D026902:Potassium Channel Blockers; D024681:Potassium Channels, Calcium-Activated; C048220:paxilline; D003606:Dacarbazine; D000077204:Temozolomide