title: Regiospecific solid-phase strategy to N7-substituted purines and its application to 8-azapurines and [I]-condensed purines.
abstract: A highly regioselective and traceless solid-phase route to 1,7,8-trisubstituted purines has been developed. This methodology could be extended to the preparation of 8-azapurines and [i]-condensed purines. A representative set of 17 purines, azapurines, and [i]-condensed purines was synthesized. This paper also describes a mild method to prepare the p-benzyloxybenzylamine (BOBA) resin.
authors: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors: Han
authors: H
authors: Fu
authors: Mark Kheng Chuan
authors: MK
authors: Tan
authors: Yulin
authors: Y
authors: Lam
mesh_terms: D006898:Hydroxylamines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011687:Purines / Q000737:chemistry*
chemical_list: D006898:Hydroxylamines; D011687:Purines; C015008:triazolopyrimidinone; C017064:benzyloxyamine