title: Predictors of gastrointestinal perforation in patients undergoing coronary artery bypass graft (CABG) surgery in Tehran, Iran.
abstract: BACKGROUND
  Gastrointestinal perforation after coronary artery bypass graft (CABG) surgery is often difficult to diagnose and is associated with high morbidity and mortality rates. The aim of this study was to determine risk factors for this complication in the studied population to further improve prophylaxis and diagnosis in the region of study.
  
  
  METHODS
  Of 8,975 consecutive patients undergoing CABG during 10 years (1995-2005), 15 (0.16%) developed gastrointestinal perforation requiring laparatomy. Data from patients who experienced gastrointestinal perforation were analyzed using univariate tests in a controlled retrospective design.
  
  
  RESULTS
  Prolonged bypass time and preoperative heparin administration were found to be significant (P<0.05) risk factors.
  
  
  CONCLUSIONS
  Low splanchnic blood flow and vasoconstriction might be underlying factors associated with both predictors. With current findings, however, clear inference about preoperative and postoperative predictors and their relation is not possible. With more information, the next step would be to build a prediction model in recognition of gastrointestinal perforation after CABG on the basis of the predisposing factors.
authors: School of Medicine, Shahid Beheshti University of Medical Sciences and Health Care, Tehran, Iran.
authors: Nouredin
authors: N
authors: Alebouyeh
authors: Mehrdad
authors: M
authors: Toefigh
authors: Nima
authors: N
authors: Ghasemzadeh
authors: Samineh
authors: S
authors: Mirheydari
authors: Ezonollah
authors: E
authors: Azargashb
mesh_terms: D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D001026:Coronary Artery Bypass; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000209:etiology*; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007416:Intestinal Perforation / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012307:Risk Factors; D013275:Stomach Rupture / Q000175:diagnosis / Q000209:etiology
chemical_list: D006493:Heparin