title: Escape mutations in HIV infection and its impact on CD8+ T cell responses.
abstract: Cellular immune responses play an important role in the control of HIV replication. Although clear evidence exists on its influence during acute HIV infection, its role during the chronic phase of the disease remains controversial. This review describes the cellular immune responses elicited against HIV mediated by CD8(+) T lymphocytes, and the mechanisms by which these cells are inefficient to completely control HIV replication and halt disease progression. The role of escape mutations as one of the most relevant mechanisms HIV has developed to evade host cellular immune responses is highlighted.
authors: Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
authors: Mariola
authors: M
authors: López
authors: Vincent
authors: V
authors: Soriano
authors: Jose Miguel
authors: JM
authors: Benito
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D009154:Mutation / Q000235:genetics*; D014779:Virus Replication