Dynamic alteration of soluble serum biomarkers in healthy aging.
Dysbalanced production of inflammatory cytokines is involved in immunosenescence in aging. The age-related changes of the levels of circulating inflammatory mediators and their clinical importance have not been investigated until recently. Still, little is known about the influence of aging on circulating levels of many cytokines, chemokines, growth factors, and angiogenic factors. In the present study, we evaluated the effect of aging on 30 different serum biomarkers involved in pro- and anti-inflammatory responses using multianalyte LabMAP Luminex technology. The simultaneous measurement of serological markers has been done in 397 healthy subjects between 40 and 80 years old. We demonstrated an increase in serum interferon-gamma-inducible chemokines (MIG and IP-10), eotaxin, chemoattractant for eosinophils, and soluble TNFR-II with advancing age. Serum levels of EGFR and EGF, important regulators of cell growth and differentiation, were decreased with age in healthy donors. These data suggest novel pathways, which may be involved in age-associated immunosenescence.
Shurin
Galina V
GV
Department of Pathology, University of Pittsburgh Medical Center, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA. shuringv@upmc.edu
Yurkovetsky
Zoya R
ZR
Chatta
Gurkamal S
GS
Tourkova
Irina L
IL
Shurin
Michael R
MR
Lokshin
Anna E
AE
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015415:Biomarkers / Q000097:blood*; D054413:Chemokine CCL11 / Q000097:blood; D054357:Chemokine CXCL10 / Q000097:blood; D054370:Chemokine CXCL9 / Q000097:blood; D004815:Epidermal Growth Factor / Q000097:blood; D066246:ErbB Receptors / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D012016:Reference Values; D012995:Solubility
D015415:Biomarkers; C114753:CXCL10 protein, human; C080810:CXCL9 protein, human; D054413:Chemokine CCL11; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9; D047889:Receptors, Tumor Necrosis Factor, Type II; D004815:Epidermal Growth Factor; C512478:EGFR protein, human; D066246:ErbB Receptors