Vaccine containing natural TLR ligands protects from Salmonella typhimurium infection in mice and acute respiratory infections in children.
It has been shown that a single parenteral administration of vaccine containing bacterial ligands for TLRI, TLR2, TLR4, TLR6, and TLR9 in mice induced rapid (24 h after administration) and effective (100%), but short-term (96 h) protection against lethal challenge with Salmonella typhimurium. Repeated mucosal applications of this vaccine stimulated long-term (up to 9 months) protection against acute respiratory infections in children of preschool age.
Semenov
Boris
B
Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia. mech.inst@mail.ru
Zverev
Vitaly
V
D000208:Acute Disease; D000818:Animals; D002648:Child; D006801:Humans; D007107:Immune System; D007113:Immunity, Innate; D008024:Ligands; D051379:Mice; D008808:Mice, Inbred CBA; D009092:Mucous Membrane / Q000276:immunology / Q000378:metabolism; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000276:immunology*; D012480:Salmonella Infections / Q000276:immunology*; D012486:Salmonella typhimurium / Q000378:metabolism*; D051193:Toll-Like Receptors / Q000737:chemistry* / Q000276:immunology*
D008024:Ligands; D051193:Toll-Like Receptors
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