[Histological comparison of different biopolymers in osseous defects].
The goal of this animal study in Goettingen minipigs was to compare Ethisorb with its modification Ethisorb Rapid where the hydrolytic degradation process has started, with respect to degradation and bony substitution qualitites. For comparison, both biopolymers were implanted with and without addition of autogenic spongiosa chips in comparison with blank defects in metaphysis of the tibia. The animals were killed after six, 12, 26 and 52 weeks. Undecalcified bone cuts were obtained and subjected to a histomorphometric and histomorphological analysis. All in all, with increasing time after implantation a continuous decrease of the density of trabecula could be observed. In comparison to Ethisorb Rapid and blank defects, the implantation of the slowly degrading but quickly resorbing Ethisorb led to statistically significantly higher densities of trabecula (Tuckey Test, p < or = 0.05) and to best bone regeneration. In contrast to this, Ethisorb Rapid could be degraded more quickly but resorbed more slowly. In the polarizing microscope, Ethisorb could still be detected after 12 weeks of implantation. Ethisorb Rapid could still be detected after 26 weeks of implantation. To conclude, Ethisorb proved to be a suitable scaffold for autogenic spongiosa-chips in critical-size defects of the tibia so that a multiloculated bone regeneration could be obtained.
Nitsch
Axel
A
Klinik und Poliklinik fur Neurochirurgie, Georg-August-Universität, Göttingen. axel.nitsch@gmx.de
Merten
Hans-Albert
HA
Verheggen
Raphaela
R
D020341:Absorbable Implants; D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation; D001842:Bone and Bones / Q000601:surgery*; D011091:Polyesters; D011100:Polyglycolic Acid; D013552:Swine; D013556:Swine, Miniature; D013977:Tibia
D018786:Bone Substitutes; C460779:Ethisorb; D011091:Polyesters; D011100:Polyglycolic Acid