Integrating molecular and network biology to decode endocytosis.
The strength of network biology lies in its ability to derive cell biological information without a priori mechanistic or molecular knowledge. It is shown here how a careful understanding of a given biological pathway can refine an interactome approach. This permits the elucidation of additional design principles and of spatio-temporal dynamics behind pathways, and aids in experimental design and interpretation.
Schmid
Eva M
EM
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.
McMahon
Harvey T
HT
D002468:Cell Physiological Phenomena; D002966:Clathrin / Q000378:metabolism*; D004705:Endocytosis; D008967:Molecular Biology; D011485:Protein Binding; D013572:Synaptic Vesicles / Q000378:metabolism; D009626:Terminology as Topic
D002966:Clathrin