Two new coumarin glucosides from the roots of Angelica apaensis and their anti-platelet aggregation activity.
Two new coumarin glucosides, 11-O-beta-D-glucopyranosyl thamnosmonin (1) and 12-O-beta-D-glucopyranosyl gosferol (2), were isolated from the roots of Angelica apaensis. Their structures were elucidated spectroscopically. Both compounds showed weak inhibitory effects on rabbit platelet aggregation induced by PAF, AA and APD.
Xiao
Wei-Lie
WL
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China.
Li
Sheng-Hong
SH
Shen
Yun-Heng
YH
Niu
Xue-Mei
XM
Sun
Han-Dong
HD
D029969:Angelica / Q000737:chemistry*; D000818:Animals; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D018517:Plant Roots / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits
C523372:11-O-glucopyranosyl thamnosmonin; C523373:12-O-glucopyranosyl gosferol; D003374:Coumarins; D005960:Glucosides; D010975:Platelet Aggregation Inhibitors