Aseptic meningitis associated with chronic sulindac use for osteoarthritis: a case report.
We report a case of aseptic meningitis thought to be associated with chronic sulindac use in a patient with osteoarthritis. The patient was hospitalized with an acute onset of headache, nuchal rigidity, nausea, and blurred vision. Brain imaging was unremarkable and a lumbar puncture revealed a lymphocytic pleocytosis. No infectious source was identified. The patient reported taking sulindac over the past year, it was discontinued, and symptoms promptly resolved. This case underscores the importance of obtaining a thorough drug history in conjunction with the knowledge of causative medications associated with aseptic meningitis. Given the widespread use of nonsteroidal anti-inflammatory drugs, clinicians must recognize that aseptic meningitis is a possible adverse effect of these medications.
Callen
Erin C
EC
College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK 73096-3098, USA. erin.callen@swosu.edu
Church
Chelsea O
CO
Patel
Manish
M
Sikes
Tiffany L
TL
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008582:Meningitis, Aseptic / Q000139:chemically induced*; D010003:Osteoarthritis / Q000188:drug therapy*; D012307:Risk Factors; D013467:Sulindac / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013467:Sulindac
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