Diversity and relationship between Iranian ethnic groups: human dopamine transporter gene (DAT1) VNTR genotyping.
The 40-bp VNTR polymorphism in the 3' untranslated region of the human DAT1 (dopamine transporter 1) was analyzed in the Iranian ethnic groups in order to examine the influence of geographical and linguistic affiliation on the genetic affinities among the Iranian population. A total of 449 subjects belonging to nine ethnic groups from the Iranian population were included in the study. The screening of 898 chromosomes showed five alleles (6, 7, 8, 9, 10, and 11), of which allele 10 revealed the highest frequency in most regions. Allele 8 was predominant in one ethnicity and occurred more frequently in the center of Iran. This study shows that the DAT1 distribution in Iran has a different pattern from those in other studies, which can contribute to an understanding of differentiation and diversity of Iranian ethnic groups. This polymorphism could represent the genetic diversity among the various ethnic groups of Iran.
Banoei
Mohammad Mehdi
MM
Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran. mmbanoei@yahoo.com
Chaleshtori
Morteza Hashemzadeh
MH
Sanati
Mohammah Hossein
MH
Panahi
Mehdi Shafa Sharait
MS
Majidizadeh
Tayebeh
T
Rostami
Maryam
M
Manshadi
Massoumeh Dehghan
MD
Golalipour
Masoud
M
D003710:Demography; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D005843:Geography; D006801:Humans; D007492:Iran; D018598:Minisatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic; D012494:Sampling Studies
D050483:Dopamine Plasma Membrane Transport Proteins