Effects of yixin jiangya capsules on insulin resistance and timor necrosis factor-alpha in cases of primary hypertension with left ventricular hypertrophy.
OBJECTIVE
To observe the effects of yixin jiangya Capsules ([Chinese characters: see text] capsules for nourishing the heart and lowering blood pressure) on insulin resistance (IR) and tumor necrosis factor-alpha (TNF-alpha) in patients with primary hypertension with left ventricular hypertrophy (LVH).


METHODS
Totally 93 cases were randomly divided into a control group of 31 cases taking Enalapril and a treatment group of 62 cases taking Enalapril and yixin jiangya Capsules.


RESULTS
Fasting serum insulin (FSI) and TNF-alpha obviously increased and insulin sensitive index (ISI) significantly decreased in both groups before treatment as compared to those of a healthy group. After treatment, FSI, TNF-alpha and fasting blood glucose (FBG) obviously decreased and ISI remarkably increased in the treatment group, while ISI significantly increased and TNF-alpha obviously decreased in the control group. The curative effect in the treatment group was remarkably superior to that in the control group. FSI was positively related to TNF-a before treatment in both groups.


CONCLUSIONS
FSI and TNF-alpha obviously increase and ISI significantly decreases in patients with primary hypertension with LVH. FSI and TNF-alpha influencing each other are involved in the generation and development of hypertension. Yixin jiangya Capsules can improve IR and decrease TNF-alpha.
Duan
Xuezhong
X
General Hospital of Jinan Military Region of PLA, Jinan 250031, China.
Zhong
Shenqing
S
Sun
Xiqing
X
Cai
Xinji
X
D000368:Aged; D002214:Capsules / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D017379:Hypertrophy, Left Ventricular / Q000150:complications*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D002214:Capsules; D004365:Drugs, Chinese Herbal; D007328:Insulin; D014409:Tumor Necrosis Factor-alpha