Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies.
Cohort studies of excess body weight and risk of liver cancer were identified for a meta-analysis by searching MEDLINE and EMBASE databases from 1966 to June 2007 and the reference lists of retrieved articles. Results from individual studies were combined using a random-effects model. We identified 11 cohort studies, of which seven on overweight (with a total of 5037 cases) and 10 on obesity (with 6042 cases) were suitable for meta-analysis. Compared with persons of normal weight, the summary relative risks of liver cancer were 1.17 (95% confidence interval (CI): 1.02-1.34) for those who were overweight and 1.89 (95% CI: 1.51-2.36) for those who were obese. This meta-analysis finds that excess body weight is associated with an increased risk of liver cancer.
Larsson
S C
SC
Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, Stockholm SE-17177, Sweden. susanna.larsson@ki.se
Wolk
A
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D016022:Case-Control Studies; D015331:Cohort Studies; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology*; D009765:Obesity / Q000150:complications*; D050177:Overweight; D018570:Risk Assessment; D012307:Risk Factors
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