title: Risk reduction with clopidogrel in the management of peripheral arterial disease.
abstract: Peripheral arterial disease (PAD) is a condition typified by decreased arterial blood flow in the non-coronary branches of the aorta as a result of chronic atherosclerosis. Despite the higher prevalence of PAD compared with other cardiovascular entities such as myocardial infarction and stroke, far less import is given to its diagnosis and treatment. In this review, we highlight principal diagnostic and therapeutic considerations in the management of PAD and its complications. We particularly emphasize the role of clopidogrel in the reduction of risks associated with PAD.
authors: Department of Cardiology, Naval Medical Center San Diego, San Diego, CA 92134, USA.
authors: Keshav R
authors: KR
authors: Nayak
authors: Jeffrey J
authors: JJ
authors: Cavendish
mesh_terms: D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D000077144:Clopidogrel; D004359:Drug Therapy, Combination; D006801:Humans; D016491:Peripheral Vascular Diseases / Q000175:diagnosis / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin
references: Lancet. 1996 Nov 16;348(9038):1329-39
references: 8918275
references: Vasc Med. 1997;2(3):169-73
references: 9546965
references: Nat Med. 1998 Nov;4(11):1241-3
references: 9809543
references: Curr Med Res Opin. 2004 Nov;20(11):1851-5
references: 15537486
references: N Engl J Med. 2005 Jan 20;352(3):238-44
references: 15659723
references: N Engl J Med. 2005 Mar 24;352(12):1179-89
references: 15758000
references: J Am Coll Cardiol. 2005 Sep 20;46(6):937-54
references: 16168274
references: Lancet. 2005 Nov 5;366(9497):1607-21
references: 16271642
references: Mayo Clin Proc. 2006 Jan;81(1):59-68
references: 16438480
references: J Am Coll Cardiol. 2006 Mar 21;47(6):1239-312
references: 16545667
references: N Engl J Med. 2006 Apr 20;354(16):1706-17
references: 16531616
references: J Am Coll Cardiol. 2006 May 16;47(10):2130-9
references: 16697342
references: J Vasc Surg. 2000 Jan;31(1 Pt 2):S1-S296
references: 10666287
references: Cochrane Database Syst Rev. 2000;(2):CD000990
references: 10796572
references: N Engl J Med. 2000 Jun 15;342(24):1773-7
references: 10852999
references: N Engl J Med. 2001 May 24;344(21):1608-21
references: 11372014
references: N Engl J Med. 2001 Aug 16;345(7):494-502
references: 11519503
references: JAMA. 2001 Oct 3;286(13):1599-606
references: 11585483
references: J Gerontol A Biol Sci Med Sci. 2002 Jan;57(1):M45-6
references: 11773211
references: BMJ. 2002 Jan 12;324(7329):71-86
references: 11786451
references: Ann Intern Med. 2002 Jun 18;136(12):873-83
references: 12069561
references: Cleve Clin J Med. 2003 May;70(5):466-70
references: 12779137
references: Circulation. 1985 Mar;71(3):510-5
references: 3156006
references: Thromb Res. 1990 Feb 15;57(4):617-23
references: 2158154
references: N Engl J Med. 1992 Feb 6;326(6):381-6
references: 1729621
references: Arterioscler Thromb. 1992 Apr;12(4):430-6
references: 1558834
references: Circulation. 1993 Sep;88(3):837-45
references: 8353913
references: J Invasive Cardiol. 2006 Apr;18(4):162-4
references: 16729401
references: Catheter Cardiovasc Interv. 2007 Jan;69(1):154
references: 17139677