title: Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men.
abstract: BACKGROUND
  Androgens are associated with metabolic risk factors in men. However, the independent impact of androgens and androgen metabolites on metabolic risk factors in men is unclear.
  
  
  OBJECTIVE
  Our objective was to determine the predictive value of serum levels of androgens and glucuronidated androgen metabolites for metabolic risk factors.
  
  
  METHODS
  We conducted a population-based study of two Swedish cohorts (1,068 young adult and 1,001 elderly men).
  
  
  METHODS
  We measured correlation of serum dihydrotestosterone (DHT), testosterone (T), and glucuronidated androgen metabolites with fat mass, fat distribution, serum lipids, and insulin resistance.
  
  
  RESULTS
  Both DHT and T were negatively associated with different measures of fat mass in both cohorts (P < 0.001). Further statistical analysis indicated that DHT, but not T, was independently negatively associated with different measures of fat mass and insulin resistance (P < 0.001). The glucuronidated androgen metabolite androstane-3alpha,17beta-diol-17glucuronide (17G) was independently positively associated with fat mass (P < 0.001). Most importantly, the 17G to DHT ratio was strongly correlated, not only with fat mass but also with central fat distribution, intrahepatic fat, disturbed lipid profile, insulin resistance, and diabetes, explaining a substantial part of the total variance in total body fat (12% in young adult men, 15% in elderly men), the homeostasis model assessment index (10%), and high-density lipoprotein cholesterol (7%).
  
  
  CONCLUSIONS
  Our findings demonstrate that 17-glucuronidation of the DHT metabolite androstane-3alpha,17beta-diol is strongly associated with several metabolic risk factors in men. Future longitudinal studies are required to determine the possible impact of the 17G to DHT ratio as a metabolic risk factor in men.
authors: Department of Internal Medicine, Gothenburg University, SE-41345 Gothenburg, Sweden.
authors: Liesbeth
authors: L
authors: Vandenput
authors: Dan
authors: D
authors: Mellström
authors: Mattias
authors: M
authors: Lorentzon
authors: Charlotte
authors: C
authors: Swanson
authors: Magnus K
authors: MK
authors: Karlsson
authors: John
authors: J
authors: Brandberg
authors: Lars
authors: L
authors: Lönn
authors: Eric
authors: E
authors: Orwoll
authors: Ulf
authors: U
authors: Smith
authors: Fernand
authors: F
authors: Labrie
authors: Osten
authors: O
authors: Ljunggren
authors: Asa
authors: A
authors: Tivesten
authors: Claes
authors: C
authors: Ohlsson
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology; D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D000728:Androgens / Q000097:blood*; D001132:Arm / Q000033:anatomy & histology; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight; D015331:Cohort Studies; D005965:Glucuronates / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007866:Leg / Q000033:anatomy & histology; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013548:Sweden; D014057:Tomography, X-Ray Computed
chemical_list: D000728:Androgens; D001786:Blood Glucose; D005965:Glucuronates; D012739:Gonadal Steroid Hormones; D007328:Insulin; D020738:Leptin; D008055:Lipids