title: Antinociceptive effect of Russelia equisetiformis leave extracts: identification of its active constituents.
abstract: This study examines the antinociceptive effect of the whole plant extracts of Russelia equisetiformis. The result shows the ethylacetate fraction to be the most active, while the dichloromethane fraction exhibited least activity. The major isolated compound from the ethylacetate showed a tremendous activity on acetic acid induced writhing with less activity on tail-flick response in mice. The structures of the two compounds were assigned on the basis of spectroscopic data. Occurrence of these compounds in Russelia is reported here for the first time, and the results confirm the traditional uses of R. equisetiformis in the treatment of inflammation and pain.
authors: Department of Veterinary Pharmacology and Therapeutics, College of Veterinary Medicine, University of Agriculture, Abeokuta, Nigeria. awemman@yahoo.co.uk
authors: E O
authors: EO
authors: Awe
authors: A
authors: A
authors: Adeloye
authors: T
authors: T
authors: Idowu
authors: O A
authors: OA
authors: Olajide
authors: J
authors: J
authors: Makinde
mesh_terms: D000700:Analgesics / Q000032:analysis*; D000818:Animals; D002301:Cardiac Glycosides / Q000032:analysis; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D028083:Scrophulariaceae / Q000737:chemistry*; D014315:Triterpenes / Q000032:analysis
chemical_list: D000700:Analgesics; D002301:Cardiac Glycosides; D010936:Plant Extracts; D014315:Triterpenes