title: Scientific evidence for a fixed extract combination (Ze 91019) from valerian and hops traditionally used as a sleep-inducing aid.
abstract: Valerian and hops are traditionally used as sleep-inducing aids. Alertness reduces gradually with the prolongation of wakefulness through the release of endogenous adenosine in the frontal basal cortex. Valerian has an adenosine-like action and supports the readiness to fall asleep. The control of the sleep-wake rhythm induces sleep when the time-related interaction is operating properly. The control is closely related to endogenous melatonin secretion. Hops act in a similar way to melatonin. Therefore, the efficacy of a valerian and hops combination in sleep disorder can scientifically be explained.
authors: Max Zeller Söhne AG, Romanshorn, Switzerland. Axel.Brattstroem@ZellerAG.ch
authors: Axel
authors: A
authors: Brattström
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004338:Drug Combinations; D006801:Humans; D027582:Humulus / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D028321:Plant Preparations; D051381:Rats; D012893:Sleep Wake Disorders / Q000188:drug therapy*; D014632:Valerian / Q000737:chemistry
chemical_list: D004338:Drug Combinations; D010936:Plant Extracts; D028321:Plant Preparations
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