title: Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in I M.
abstract: Previous work done by our laboratory has demonstrated a reduction of the post-burst afterhyperpolarization (AHP) and accommodation following trace eyeblink conditioning in rabbit CA1 pyramidal neurons. Our laboratory has also demonstrated a reduction in the AHP in rat CA1 pyramidal neurons following spatial learning. In the current study we have extended our findings in rabbits by showing a reduction in both the AHP and accommodation in F344 X BN rat CA1 pyramidal neurons following acquisition of trace eyeblink conditioning. A component current of the AHP, I(M), was evaluated with a specific blocker of this current, and showed no apparent contribution to the learning-related increase in neuronal excitability. Rather, a reduction in an isoproterenol-sensitive component of the AHP, presumably sI(AHP), was observed to underlie the learning-specific change.
authors: Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. agkuo@umich.edu
authors: Amy G
authors: AG
authors: Kuo
authors: Grace
authors: G
authors: Lee
authors: Bridget M
authors: BM
authors: McKay
authors: John F
authors: JF
authors: Disterhoft
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001143:Arousal / Q000187:drug effects*; D001767:Blinking / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D004576:Electromyography; D006624:Hippocampus / Q000187:drug effects; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D018408:Patch-Clamp Techniques; D024681:Potassium Channels, Calcium-Activated / Q000378:metabolism*; D017966:Pyramidal Cells / Q000187:drug effects*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000318:Adrenergic beta-Agonists; D024681:Potassium Channels, Calcium-Activated; D007545:Isoproterenol
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