title: Expression of G3BP and RhoC in esophageal squamous carcinoma and their effect on prognosis.
abstract: OBJECTIVE
  To investigate the expression and significance of G3BP and RhoC proteins in esophageal squamous carcinoma (ESC).
  
  
  METHODS
  The expression of G3BP and Rhoc proteins in 80 cases of ESC was detected by immunohistochemistry. The relationship was studied between the expression of the two proteins and tumor size, differentiation degree, TNM stage, lymph node metastasis and prognosis of ESC.
  
  
  RESULTS
  The positive expression rate of G3BP in ESC was 71.25%; and the rate in the lymph node metastasis group was significantly higher than that in the non-lymph node metastasis group (Z = -2.283, P = 0.022), but no relations were found between G3BP expression and tumor size, differentiation degree and TNM stage (P > 0.05). The group with G3BP positive expression had shorter survival time than the group with G3BP negative expression (P = 0.000). The positive expression rate of RhoC in ESC was 66.25%; and the rate in the lymph node metastasis group was significantly higher than that in the non-lymph node metastasis group (Z = -2.115, P < 0.05), but no relations were found between RhoC expression and tumor size, differentiation degree and TNM stage (P > 0.05). The RhoC positive expression group had a shorter survival time than the RhoC negative expression group (P < 0.001. The expression of G3BP protein correlated positively with the expression of RhoC in ESC tissues (rs = 0.656, P < 0.001).
  
  
  CONCLUSIONS
  The expression of G3BP and RhoC protein is closely related to the lymph node metastasis and survival in ESC patients. G3BP and RhoC proteins can be considered as predictors of prognosis in ESC patients.
authors: Department of Cardiothoracic Surgery, The Second Affiliated Hospital, Sun Yat-en University, 107 Yan-Jiang Road, Guangzhou 510120, Guangdong Province, China.
authors: Hui-Zhong
authors: HZ
authors: Zhang
authors: Jin-Geng
authors: JG
authors: Liu
authors: Yi-Ping
authors: YP
authors: Wei
authors: Cheng
authors: C
authors: Wu
authors: Yong-Ke
authors: YK
authors: Cao
authors: Mei
authors: M
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D002352:Carrier Proteins / Q000378:metabolism*; D004265:DNA Helicases; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D000075223:Poly-ADP-Ribose Binding Proteins; D011237:Predictive Value of Tests; D011379:Prognosis; D020365:RNA Helicases; D000067776:RNA Recognition Motif Proteins; D020741:rho GTP-Binding Proteins / Q000378:metabolism*; D000075024:rhoC GTP-Binding Protein
chemical_list: D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D000075223:Poly-ADP-Ribose Binding Proteins; D000067776:RNA Recognition Motif Proteins; D004265:DNA Helicases; C116070:G3BP1 protein, human; D020365:RNA Helicases; C066690:RHOC protein, human; D020741:rho GTP-Binding Proteins; D000075024:rhoC GTP-Binding Protein
references: Chin Med J (Engl). 2005 Mar 20;118(6):502-4
references: 15788133
references: Nature. 2000 Aug 3;406(6795):532-5
references: 10952316
references: Cancer Lett. 2001 Jan 26;162(2):213-21
references: 11146228
references: Histochem J. 2002 May;34(5):223-31
references: 12587999
references: Pathol Res Pract. 1996 Sep;192(9):883-91
references: 8950754
references: Science. 1993 Jan 22;259(5094):525-8
references: 7678707
references: Oncogene. 1997 Oct 9;15(15):1823-32
references: 9362449
references: Eur J Cancer. 2006 Jul;42(10):1455-65
references: 16750623
references: Cell. 1985 May;41(1):31-40
references: 3888408
references: Zhonghua Bing Li Xue Za Zhi. 2005 Apr;34(4):215-9
references: 16091175
references: Mol Cell Biol. 1998 Sep;18(9):5567-78
references: 9710640
references: Oncogene. 2006 Apr 13;25(16):2285-96
references: 16314838
references: Mol Cell Biol. 1996 Jun;16(6):2561-9
references: 8649363
references: Breast Cancer Res Treat. 2005 Sep;93(2):101-10
references: 16187229