title: A special case of bilateral ovarian metastases in a woman with papillary carcinoma of the thyroid.
abstract: Papillary thyroid carcinoma is a slow growing tumor with low metastatic potential. The most frequent sites of distant metastases are lung and bone; less frequent sites are brain, liver, kidney, and skin. Ovarian metastases from papillary thyroid carcinoma are exceptional. We describe a case of bilateral ovarian metastases from a papillary thyroid carcinoma associated with autoimmune thyroiditis in a 38-year-old woman who underwent thyroidectomy and cervical lymph-node dissection 7 years before, followed by 948 mCi of 131I. A primary ovarian cancer could be excluded by the typical pathological aspects of a papillary thyroid carcinoma in a context of an aggressive form of thyroid cancer. On the other hand, the clinical history and the absence of normal thyroid epithelium and teratomatous components could exclude a papillary thyroid carcinoma arising in struma ovarii. This is a singular case of papillary thyroid carcinoma metastasizing to the ovary, combined with an autoimmune thyroiditis.
authors: Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa, Pisa, Italy.
authors: S
authors: S
authors: Brogioni
authors: P
authors: P
authors: Viacava
authors: L
authors: L
authors: Tomisti
authors: E
authors: E
authors: Martino
authors: E
authors: E
authors: Macchia
mesh_terms: D000328:Adult; D002291:Carcinoma, Papillary / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000556:secondary* / Q000628:therapy; D011879:Radiotherapy Dosage; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000628:therapy; D013965:Thyroidectomy