title: Flatiron mice and ferroportin disease.
abstract: Flatiron mice provide the first genetic model that fully recapitulates the iron-loading disorder ferroportin disease. Unlike the other known genetic causes of hemochromatosis, missense mutations in the ferroportin gene are autosomal dominant. These new findings show that ferroportin disease results from dominant negative effects rather than haplo-insufficiency.
authors: Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
authors: Erin E
authors: EE
authors: Johnson
authors: Marianne
authors: M
authors: Wessling-Resnick
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D027682:Cation Transport Proteins / Q000235:genetics*; D004195:Disease Models, Animal; D005799:Genes, Dominant; D006432:Hemochromatosis / Q000235:genetics*; D006801:Humans; D007501:Iron / Q000378:metabolism; D019189:Iron Metabolism Disorders / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D009154:Mutation; D000098742:Ferroportin
chemical_list: D027682:Cation Transport Proteins; D000098742:Ferroportin; D007501:Iron
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