title: Are numbers special? Comparing the generation of verbal materials from ordered categories (months) to numbers and other categories (animals) in an fMRI study.
abstract: Months, days of the week, and numbers differ from other verbal concepts because they are ordered in a sequence, whereas no order is imposed on members of other categories, such as animals or tools. Recent studies suggest that numbers activate a representation of their quantity within the intraparietal sulcus (IPS) automatically, that is, in tasks that do not require the processing of quantity. It is unclear, however, whether ordered verbal materials in general and not only numbers activate the IPS in such tasks. In the present functional magnetic resonance imaging study word generation of months, numbers, and animals were compared. Word generation of numbers and nonnumerical materials from an ordered category (months) activated the IPS more strongly than generating items from a not-ordered category such as animals or the verbal control conditions. An ROI analysis of three subregions within the anterior IPS revealed that the most anterior and lateral of these regions, human intraparietal area hIP2, shows a greater sensitivity to ordered materials than the other two areas, hIP1 and hIP3. Interestingly, no difference in activation was observed within the IPS between numbers and months suggesting that the activation of the IPS might not be modulated by the additional quantity information carried by numbers.
authors: Clinical Department of Neurology, Innsbruck Medical University, Austria. anja.ischebeck@i-med.ac.at
authors: Anja
authors: A
authors: Ischebeck
authors: Stefan
authors: S
authors: Heim
authors: Christian
authors: C
authors: Siedentopf
authors: Laura
authors: L
authors: Zamarian
authors: Michael
authors: M
authors: Schocke
authors: Christian
authors: C
authors: Kremser
authors: Karl
authors: K
authors: Egger
authors: Hans
authors: H
authors: Strenge
authors: Filip
authors: F
authors: Scheperjans
authors: Margarete
authors: M
authors: Delazer
mesh_terms: D000818:Animals; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008433:Mathematics; D010296:Parietal Lobe / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology; D013850:Thinking / Q000502:physiology; D014706:Verbal Learning / Q000145:classification* / Q000502:physiology*
references: Neuropsychologia. 2006;44(10):1708-23
references: 16697429
references: Neuroscience. 2006 Apr 28;139(1):311-6
references: 16417974
references: Neuron. 2004 Oct 28;44(3):547-55
references: 15504333
references: Neuropsychologia. 2001;39(11):1224-39
references: 11527560
references: Trends Cogn Sci. 2003 Aug;7(8):335-338
references: 12907224
references: Nat Rev Neurosci. 2005 Jun;6(6):435-48
references: 15928716
references: Trends Cogn Sci. 2003 Aug;7(8):354-361
references: 12907231
references: Arch Clin Neuropsychol. 1999 Feb;14(2):167-77
references: 14590600
references: Neuroimage. 2004 May;22(1):42-56
references: 15109996
references: Neuroimage. 2004 Nov;23(3):1046-58
references: 15528105
references: Brain Res Cogn Brain Res. 2004 Sep;21(1):22-38
references: 15325410
references: Curr Opin Neurobiol. 2001 Apr;11(2):194-201
references: 11301239
references: Neuroimage. 2001 Jul;14(1 Pt 1):182-93
references: 11525327
references: J Comp Neurol. 2006 Mar 1;495(1):53-69
references: 16432904
references: Cognition. 1990 Aug;36(2):155-93
references: 2225756
references: Brain. 2002 May;125(Pt 5):1024-38
references: 11960893
references: Neuroimage. 2000 Dec;12(6):713-25
references: 11112403
references: Brain. 2000 Nov;123 ( Pt 11):2240-55
references: 11050024
references: Neurosci Lett. 2003 Jul 10;345(1):25-8
references: 12809980
references: J Cogn Neurosci. 2004 Nov;16(9):1493-504
references: 15601514
references: J Exp Psychol Learn Mem Cogn. 1984 Jan;10(1):61-71
references: 6242736
references: Neuropsychologia. 2006;44(1):36-51
references: 15936044
references: Neuroimage. 2004 Nov;23(3):1192-202
references: 15528119
references: Brain Res Cogn Brain Res. 2005 Jul;24(2):284-90
references: 15993766
references: Neuroimage. 2006 May 1;30(4):1365-75
references: 16413795
references: Rev Neurol (Paris). 1961 Aug;105:85-103
references: 13905817
references: Neuropsychologia. 2005;43(5):744-53
references: 15721187
references: Neuroimage. 2002 Feb;15(2):435-46
references: 11798277
references: Brain. 1991 Dec;114 ( Pt 6):2619-37
references: 1782535
references: Neuropsychologia. 2005;43(9):1238-48
references: 15949508
references: Neuroimage. 2003 Nov;20 Suppl 1:S50-7
references: 14597296
references: J Comp Neurol. 1999 Sep 20;412(2):319-41
references: 10441759
references: Neuroimage. 2002 Jan;15(1):273-89
references: 11771995
references: Neuropsychologia. 1998 Jun;36(6):499-504
references: 9705059
references: Neuroimage. 2006 Aug 15;32(2):570-82
references: 16781166
references: Neuron. 2004 Oct 28;44(3):557-69
references: 15504334
references: Neuroimage. 2006 Feb 15;29(4):1278-93
references: 16412665
references: Brain Cogn. 1993 Nov;23(2):231-42
references: 8292327
references: Cognition. 2006 Jan;98(3):273-85
references: 16399265
references: Psychiatry Clin Neurosci. 2000 Aug;54(4):479-85
references: 10997866
references: Proc Biol Sci. 2003 Jun 22;270(1521):1237-45
references: 12816636
references: Cognition. 2003 Apr;87(3):B87-95
references: 12684205
references: AJNR Am J Neuroradiol. 2003 Feb;24(2):193-200
references: 12591633
references: Nature. 1967 Sep 30;215(5109):1519-20
references: 6052760
references: Hum Brain Mapp. 2005 Aug;25(4):409-23
references: 15852470
references: J Cogn Neurosci. 1999 Nov;11(6):617-30
references: 10601743
references: Neuron. 2003 Feb 20;37(4):719-25
references: 12597867
references: Neuroimage. 2005 Apr 15;25(3):838-49
references: 15808984
references: Neuroreport. 2000 Jun 26;11(9):1997-2000
references: 10884059
references: Neuropsychologia. 2006;44(3):469-78
references: 16005031
references: Brain. 2002 Aug;125(Pt 8):1829-38
references: 12135973
references: Neuropsychology. 1998 Apr;12(2):259-67
references: 9556772
references: Cortex. 1997 Dec;33(4):697-710
references: 9444471
references: J Neurol Neurosurg Psychiatry. 1998 Apr;64(4):492-8
references: 9576541
references: Neuroimage. 2001 Nov;14(5):1013-26
references: 11697933
references: Cognition. 2006 Aug;101(1):114-28
references: 16288733
references: Neuron. 2004 Mar 25;41(6):983-93
references: 15046729
references: Neuroimage. 2005 May 1;25(4):1325-35
references: 15850749
references: Q J Exp Psychol A. 1998 Nov;51(4):819-52
references: 9854442
references: Cortex. 1978 Dec;14(4):540-56
references: 738063
references: Hum Brain Mapp. 2003 Mar;18(3):176-85
references: 12599275
references: Curr Opin Neurobiol. 2004 Apr;14(2):218-24
references: 15082328
references: Brain Lang. 2005 Apr;93(1):32-45
references: 15766766
references: Hum Brain Mapp. 2006 Oct;27(10):799-810
references: 16511886
references: Cortex. 2004 Feb;40(1):171-2
references: 15174454