Preoperative serum C-reactive protein level in non-small cell lung cancer.
We evaluated the significance of the preoperative serum C-reactive protein (CRP) level as a prognostic indicator in patients with non-small cell lung cancer (NSCLC).


METHODS
Two hundred and three patients who had undergone a curative resection of NSCLC were retrospectively reviewed.


RESULTS
The proportion of the tumor size over 3 cm per patient in the CRP-positive group (> or =0.5 mg/dL: n=38) was significantly higher than that in the CRP-negative group (<0.5 mg/dL: n = 165). The proportion of the adenocarcinoma in CRP-positive group was significantly lower than that in CRP-negative group. The overall and disease specific survival rates in the CRP-positive group were significantly lower than the rates in the CRP-negative group. Based on a multivariate analysis, the preoperative serum CRP level was selected as one of the unfavorable indicators regarding survival.


CONCLUSIONS
The preoperative serum CRP level is an independent and significant indicator predictive of a poor prognosis in patients with NSCLC.
Hara
Masaki
M
Department of Cardiovascular, Thoracic and General Surgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. haramasa@med.miyazaki-u.ac.jp
Matsuzaki
Yasunori
Y
Shimuzu
Tetsuya
T
Tomita
Masaki
M
Ayabe
Takanori
T
Enomoto
Yusuke
Y
Onitsuka
Toshio
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D015996:Survival Rate
D002097:C-Reactive Protein