Transcriptome analysis of cold syndrome using microarray.
Microarrays are widely used to study changes in gene expression in diseases. In this paper, we use this technology to discover gene expression patterns in the cold syndrome in Chinese medicine. We identify differentially expressed genes and extracted gene modules that are enriched with differentially expressed genes in the cold syndrome by analyzing cDNA samples, which are purified from blood taken from a pedigree. Our results suggest that the cold syndrome might be caused by the physiological imbalance and/or the disorder of metabolite processes. The study confirms the hypotheses about molecular pathways responsible to human metabolic-related diseases.
Yang
Liping
L
Laboratory of Chinese Medicine Genetics, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
Wang
Miqu
M
Wu
Wei
W
Zhang
Louxin
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D001831:Body Temperature / Q000235:genetics*; D002648:Child; D003080:Cold Temperature; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000235:genetics*; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D010375:Pedigree; D010698:Phobic Disorders / Q000235:genetics*; D013577:Syndrome; D013697:Thermosensing / Q000235:genetics