title: Preparation and characterization of magnetic poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) microspheres.
abstract: In this article, nano-magnetite particles (ferrofluid, Fe3O4) were prepared by chemical co-deposition method. A series of biodegradable triblock poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL, PCEC) copolymers were synthesized by ring-opening polymerization method from epsilon-caprolactone (epsilon-CL) initiated by poly(ethylene glycol) diol (PEG) using stannous octoate as catalyst. And the magnetic PCEC composite microspheres were prepared by solvent diffusion method. The properties of the ferrofluid, PCEC copolymer, and magnetic PCEC microspheres were studied in detail by SEM, VSM, XRD, Malvern Laser Particle Sizer, 1H-NMR, GPC, and TG/DTG. Effects of macromolecular weight and concentration of polymer, and the time for ultrasound dispersion on properties of magnetic microspheres were also investigated. The obtained magnetic PCEC microspheres might have great potential application in targeted drug delivery system or cell separation.
authors: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China.
authors: Ma Ling
authors: ML
authors: Gou
authors: Zhi Yong
authors: ZY
authors: Qian
authors: Hui
authors: H
authors: Wang
authors: Yong Bo
authors: YB
authors: Tang
authors: Mei Juan
authors: MJ
authors: Huang
authors: Bing
authors: B
authors: Kan
authors: Yan Juan
authors: YJ
authors: Wen
authors: Mei
authors: M
authors: Dai
authors: Xing Yi
authors: XY
authors: Li
authors: Chang Yang
authors: CY
authors: Gong
authors: Ming Jing
authors: MJ
authors: Tu
mesh_terms: D005290:Ferric Compounds / Q000138:chemical synthesis; D008280:Magnetics; D008863:Microspheres; D008954:Models, Biological; D008970:Molecular Weight; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry*; D016062:Porosity; D013696:Temperature
chemical_list: D005290:Ferric Compounds; D011091:Polyesters; C492324:poly(epsilon-caprolactone)-poly(oxyethylene)-poly(epsilon-caprolactone); C000499:ferric oxide; D011092:Polyethylene Glycols
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