Improved efficacy of a licensed acellular pertussis vaccine, reformulated in an adjuvant emulsion of liposomes in oil, in a murine model.
The immunogenicities and efficacies of a licensed diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine and the same vaccine formulated in a liposome/oil emulsion adjuvant were compared in a mouse model of pertussis respiratory infection. A single dose of the liposome/oil emulsion-adjuvanted vaccine produced significantly higher antibody levels than one dose of the licensed vaccine and protected mice from Bordetella pertussis infection with an efficacy equivalent to that of three doses of the licensed vaccine.
Mansour
Marc
M
ImmunoVaccine Technologies Inc., Dalhousie University, Halifax, Nova Scotia, Canada.
Brown
Robert G
RG
Morris
Annette
A
Smith
Bruce
B
Halperin
Scott A
SA
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology*; D017277:Drug Approval; D016503:Drug Delivery Systems; D004655:Emulsions; D005260:Female; D007115:Immunization Schedule; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D009821:Oils; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology* / Q000592:standards; D022282:Vaccines, Acellular / Q000008:administration & dosage / Q000276:immunology / Q000592:standards
D000276:Adjuvants, Immunologic; D004655:Emulsions; D008081:Liposomes; D009821:Oils; D010567:Pertussis Vaccine; D022282:Vaccines, Acellular
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