title: Deleting islet autoimmunity.
abstract: Even though there are numerous autoantigens for type 1 diabetes, current evidence suggests that a single autoantigen, namely insulin, is responsible for the key initiating event in autoimmunity. If a single autoantigen is necessary for triggering the autoimmune process, then antigen-specific therapy to block or delete the immune response against that autoantigen before epitope spreading occurs, may become a larger focus of future immunotherapeutic strategies. In this article, we review current literature regarding insulin as an autoantigen and potential approaches to deleting insulin-reactive T cells through the use of peptide vaccines and targeted T cell receptor immunizations.
authors: Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO, USA.
authors: Edwin
authors: E
authors: Liu
authors: Marcella
authors: M
authors: Li
authors: Jean
authors: J
authors: Jasinski
authors: Masakazu
authors: M
authors: Kobayashi
authors: Roberto
authors: R
authors: Gianani
authors: Maki
authors: M
authors: Nakayama
authors: George S
authors: GS
authors: Eisenbarth
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000628:therapy; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D007167:Immunotherapy; D007328:Insulin / Q000276:immunology*; D007515:Islets of Langerhans / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001324:Autoantigens; D018984:Epitopes, T-Lymphocyte; D007328:Insulin; D010446:Peptide Fragments; C097877:insulin B (9-23)