title: Single-walled carbon nanotubes in the intact organism: near-IR imaging and biocompatibility studies in Drosophila.
abstract: The ability of near-infrared fluorescence imaging to detect single-walled carbon nanotubes (SWNTs) in organisms and biological tissues has been explored using Drosophila melanogaster (fruit flies). Drosophila larvae were raised on food containing approximately 10 ppm of disaggregated SWNTs. Their viability and growth were not reduced by nanotube ingestion. Near-IR nanotube fluorescence was imaged from intact living larvae, and individual nanotubes in dissected tissue specimens were imaged, structurally identified, and counted to estimate a biodistribution.
authors: Department of Chemistry, Center for Biological and Environmental Nanotechnology, R. E. Smalley Institute for Nanoscale Science and Technology, and Institute for Biosciences and Bioengineering, Rice University, 6100 Main Street, Houston, Texas 77005, USA.
authors: Tonya K
authors: TK
authors: Leeuw
authors: R Michelle
authors: RM
authors: Reith
authors: Rebecca A
authors: RA
authors: Simonette
authors: Mallory E
authors: ME
authors: Harden
authors: Paul
authors: P
authors: Cherukuri
authors: Dmitri A
authors: DA
authors: Tsyboulski
authors: Kathleen M
authors: KM
authors: Beckingham
authors: R Bruce
authors: RB
authors: Weisman
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004331:Drosophila melanogaster / Q000737:chemistry* / Q000187:drug effects; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009928:Organ Specificity; D013055:Spectrophotometry, Infrared / Q000379:methods*; D014018:Tissue Distribution
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon