title: Preference-based quality of life measures in people with visual impairment.
abstract: The use of preference-based measures of quality of life represents the application of principles of decision theory and welfare economics to the measurement of health-related concepts. In this Perspective, we present the theoretical basis of preference-based measures in the assessment of the impact of vision-related disease on quality of life and their role in cost-effectiveness analysis. We discuss the use of the standard gamble and time trade-off in eliciting utilities and the limitations of both methods. Scaling issues related to utility are discussed, in particular the reasons for use of the "policy scale" (i.e., a scale where utilities are anchored at 1.0 for perfect health and 0 as death). This is contrasted with the use of the "vision-truncated scale" (i.e., a scale with 1.0 representing perfect vision and 0 being death), which is commonly used in assessment of vision-related utilities. We discuss problematic aspects of using the truncated scale in conducting cost-effectiveness research for vision-related disease, and provide a theoretical and empirical discussion of these limitations. In particular, we point out how these results raise questions concerning the conceptual relationship between vision- and health-related quality of life. Finally, we present the results of previous cross-cultural and trans-national studies of vision-related quality of life to demonstrate how utility studies might provide insight into the meaning of disease across cultures.
authors: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110-1093, USA. kymes@vrcc.wustl.edu
authors: Steven M
authors: SM
authors: Kymes
authors: Bryan S
authors: BS
authors: Lee
mesh_terms: D002755:Choice Behavior; D003662:Decision Theory; D006304:Health Status; D006801:Humans; D017063:Outcome Assessment, Health Care; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D044469:Racial Groups; D012737:Sex Factors; D014786:Vision Disorders / Q000503:physiopathology* / Q000523:psychology; D014792:Visual Acuity