title: The effect of nasal steroid administration on intraocular pressure.
abstract: The effect of systemic steroid administration on intraocular pressure (IOP) is well established. However less attention has been paid to the effect of steroids when administered in a nasal spray. We conducted a study to investigate a possible association between nasal steroids and elevated IOP in 54 patients who were being treated for allergic rhinitis. IOP was measured before the patients started therapy and thereafter every 5 days during that therapy. Follow-up ranged from 27 to 35 days (mean: 31). Statistical analysis revealed no significant elevation in IOP after nasal steroid administration. It seems that short-term administration of nasal steroids does not cause significant IOP elevation. Nevertheless, their long-term effects on this pressure should be investigated.
authors: Department of Ophthalmology, University Hospital of Patras Medical School, Patras, Greece. c.spiliotopoulos@yahoo.com
authors: Christos
authors: C
authors: Spiliotopoulos
authors: Nicholas S
authors: NS
authors: Mastronikolis
authors: Ioannis K
authors: IK
authors: Petropoulos
authors: Ephigenia K
authors: EK
authors: Mela
authors: Panos D
authors: PD
authors: Goumas
authors: Sotirios P
authors: SP
authors: Gartaganis
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D003907:Dexamethasone / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
chemical_list: D004338:Drug Combinations; D005938:Glucocorticoids; D007093:Imidazoles; D003907:Dexamethasone; C005370:tramazoline