title: Drug treatment improves memory in mice.
abstract: Mice that carry additional copies of genes comparable to those present on human chromosome 21 have been shown to perform better on memory tests when treated with drugs that target brain function. Could this be an important break-through in the search for pharmacological therapies to assist people with Down syndrome?
authors: The Down Syndrome Educational Trust, Portsmouth, Hampshire, UK. frank.buckley@downsed.org
authors: Frank
authors: F
authors: Buckley
authors: Ben
authors: B
authors: Sacks
mesh_terms: D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D002891:Chromosomes, Human, Pair 21; D003517:Cyclopentanes / Q000494:pharmacology; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D005663:Furans / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology*; D046934:Ginkgolides / Q000494:pharmacology; D006801:Humans; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008822:Mice, Transgenic; D009483:Neuropsychological Tests; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology
chemical_list: D000697:Central Nervous System Stimulants; D003517:Cyclopentanes; D005663:Furans; D018756:GABA Antagonists; D046934:Ginkgolides; D010433:Pentylenetetrazole; D010852:Picrotoxin; C073710:bilobalide