title: Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus.
abstract: A series of HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. The synthesis and biological activity of the compounds are described.
authors: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. subha_raghavan@merck.com
authors: Subharekha
authors: S
authors: Raghavan
authors: Zhijian
authors: Z
authors: Lu
authors: Teresa
authors: T
authors: Beeson
authors: Kevin T
authors: KT
authors: Chapman
authors: William A
authors: WA
authors: Schleif
authors: David B
authors: DB
authors: Olsen
authors: Mark
authors: M
authors: Stahlhut
authors: Carrie A
authors: CA
authors: Rutkowski
authors: Lori
authors: L
authors: Gabryelski
authors: Emilio
authors: E
authors: Emini
authors: James R
authors: JR
authors: Tata
mesh_terms: D002460:Cell Line; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007202:Indicators and Reagents; D019469:Indinavir / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D017320:HIV Protease Inhibitors; D007202:Indicators and Reagents; D019469:Indinavir