title: The "pressure pan" evolution of human erythrovirus B19 in the Amazon, Brazil.
abstract: To understand the evolutionary dynamics of human parvovirus B19, we analyzed VP1 and VP2 gene sequences of B19 sampled from Belém (Amazon), the city of São Paulo, Brazil and globally. Our analysis revealed a strikingly different pattern of evolutionary change for those viral lineages introduced into Belém, which exhibited a higher rate of nonsynonymous substitutions compared to those viruses sampled from other locations. We propose that difference this is due to the high prevalence of B19 in Belém (up to 85%) compared to other locations (prevalences of approximately 50%), which imposes a more intense selection pressure. Hence, those B19 lineages introduced into Belém experienced an elevated rate of amino acid change, driven by positive selection, in order to generate serial re-infections in a small web of transmission, which can be thought of as an evolutionary "pressure pan".
authors: Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Belém, Brazil.
authors: Ronaldo
authors: R
authors: Barros de Freitas
authors: Edison Luiz
authors: EL
authors: Durigon
authors: Darleise de Souza
authors: Dde S
authors: Oliveira
authors: Camila Malta
authors: CM
authors: Romano
authors: Maria Rute
authors: MR
authors: Castro de Freitas
authors: Alexandre da Costa
authors: Ada C
authors: Linhares
authors: Fernando Lucas
authors: FL
authors: Melo
authors: Lílian
authors: L
authors: Walshkeller
authors: Maria Luisa
authors: ML
authors: Barbosa
authors: Egma M Mayta
authors: EM
authors: Huatuco
authors: Edward C
authors: EC
authors: Holmes
authors: Paolo Marinho de A
authors: PM
authors: Zanotto
mesh_terms: D001499:Bayes Theorem; D001938:Brazil; D036022:Capsid Proteins / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D016731:Erythema Infectiosum / Q000821:virology; D019143:Evolution, Molecular; D005814:Genes, Viral; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010322:Parvoviridae Infections / Q000821:virology; D016732:Parvovirus B19, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D012641:Selection, Genetic
chemical_list: D036022:Capsid Proteins; D004279:DNA, Viral; C095547:capsid protein VP1, parvovirus B19; C095548:capsid protein VP2, parvovirus B19