Amphetamine-associated ischemic stroke: clinical presentation and proposed pathogenesis.
We report a young lady with acute left middle cerebral artery infarction after acute intake of amphetamine. This is the first case report of amphetamine-induced ischemic stroke with serial angiography and transcranial color-coded Doppler studies. The temporal sequence of stenosis of at least 3 weeks with subsequent complete resolution by 3 months and a "beaded" appearance on angiography support vasculitis or vasospasm as the pathogenesis of ischemic stroke in this patient. The presence of microembolic signals supports acute thrombosis at the site of vasculitis/vasospasm with distal embolism.
De Silva
Deidre Anne
DA
Singapore General Hospital, National Neuroscience Institute, Singapore. gnrdsd@sgh.com.sg <gnrdsd@sgh.com.sg>
Wong
Meng Cheong
MC
Lee
Moi Pin
MP
Chen
Christopher Li-Hsian
CL
Chang
Hui Meng
HM
D000328:Adult; D000435:Alcoholic Intoxication / Q000150:complications; D001037:Aphasia / Q000209:etiology; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000209:etiology*; D002533:Cerebral Angiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000209:etiology*; D020766:Intracranial Embolism / Q000000981:diagnostic imaging / Q000209:etiology; D020767:Intracranial Thrombosis / Q000209:etiology; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000009:adverse effects*; D010291:Paresis / Q000209:etiology; D010468:Perceptual Disorders / Q000209:etiology; D017585:Ultrasonography, Doppler, Transcranial; D020293:Vasculitis, Central Nervous System / Q000139:chemically induced* / Q000150:complications; D020301:Vasospasm, Intracranial / Q000139:chemically induced* / Q000150:complications
D018817:N-Methyl-3,4-methylenedioxyamphetamine