Cooperativity in glycan-protein interactions.
Using FGF-2 HSGAGs as a model, de Paz and colleagues [1] have demonstrated the importance of multivalency in cooperative glycan-protein interactions to achieve specificity.
Raman
Rahul
R
Department of Biological Engineering, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Sasisekharan
Ram
R
D019812:Heparan Sulfate Proteoglycans / Q000096:biosynthesis / Q000378:metabolism*; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*
D019812:Heparan Sulfate Proteoglycans; D011506:Proteins