Alpha-synuclein and its role in metal binding: relevance to Parkinson's disease.
Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha-synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha-synuclein and its interaction with metals.
Wright
Josephine A
JA
Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.
Brown
David R
DR
D000818:Animals; D003300:Copper / Q000378:metabolism; D006801:Humans; D008670:Metals / Q000378:metabolism*; D008968:Molecular Conformation; D009474:Neurons / Q000378:metabolism*; D010084:Oxidation-Reduction; D010302:Parkinson Disease, Secondary / Q000209:etiology* / Q000378:metabolism*; D017510:Protein Folding; D011506:Proteins / Q000378:metabolism; D051844:alpha-Synuclein / Q000737:chemistry / Q000378:metabolism*
D008670:Metals; D011506:Proteins; D051844:alpha-Synuclein; D003300:Copper