title: Giant cell tumor of bone in children and adolescents.
abstract: BACKGROUND
  There are very few series that document giant cell tumor of bone (GCT) in the immature skeleton, and the reported incidence in literature varies from 1.8% to 10.6%. The purpose of this study was to document the incidence of GCT in patients with open physis in the Indian population and study the course of the disease with respect to its adult counterpart to see if it behaved any differently.
  
  
  METHODS
  Between January 2000 and December 2005, 17 (6%) of 285 surgically treated patients with histologically proven GCT had open physis on imaging. Treatment was directed toward local control without sacrificing joint function, with most lesions treated with intralesional curettage.
  
  
  RESULTS
  Fourteen (82%) patients were girls. The most common site was around the knee (53%). Of 15 lesions in tubular bones, 13 were epiphysiometaphyseal in location. An open physis did not prevent GCT from penetrating the epiphyseal cartilage. Histologically, the tumors were typical of GCT. Of 15 patients available for follow-up, 3 (20%) developed local recurrence.
  
  
  CONCLUSIONS
  Although the overall incidence of GCT may be higher in the Asian population, the percentage of skeletally immature patients or those nearing skeletal maturity is similar to that described in literature. The biological behavior of the disease is similar to that seen in adults, except a marked female preponderance, principles of treatment, recurrence patterns, and course of the disease mirror the behavior of its adult counterpart.
authors: Tata Memorial Hospital, Mumbai, India. docpuri@vsnl.com
authors: Ajay
authors: A
authors: Puri
authors: Manish G
authors: MG
authors: Agarwal
authors: Mandip
authors: M
authors: Shah
authors: Nirmala A
authors: NA
authors: Jambhekar
authors: Chetan
authors: C
authors: Anchan
authors: Sanica
authors: S
authors: Behle
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001859:Bone Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D002648:Child; D003475:Curettage; D018450:Disease Progression; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D009364:Neoplasm Recurrence, Local; D012737:Sex Factors