The role of nutritional therapy in alcoholic liver disease.
Alcoholic liver disease (ALD) evolves through various stages, and malnutrition correlates with the severity of ALD. Poor nutrition is caused both by the substitution of calories from alcohol for calories from food and by the malabsorption and maldigestion of various nutrients attributed to ALD. The only established therapy for ALD consists of abstinence from alcohol. Sufficient nutritional repletion coupled with appropriate supportive treatment modalities may be effective in reducing complications associated with ALD---particularly infection. Nutrition makes a significant positive contribution in the treatment of ALD, especially in selected malnourished patients.
Griffith
Christopher M
CM
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Schenker
Steven
S
D004041:Dietary Fats / Q000009:adverse effects; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000150:complications / Q000178:diet therapy* / Q000188:drug therapy / Q000401:mortality; D044342:Malnutrition / Q000150:complications / Q000178:diet therapy*; D020944:Silybum marianum; D008517:Phytotherapy; D012436:S-Adenosylmethionine / Q000627:therapeutic use
D004041:Dietary Fats; D012436:S-Adenosylmethionine
J Hepatol. 1999 Jun;30(6):1081-9
10406187
J Am Coll Nutr. 1999 Oct;18(5):434-41
10511325
Hepatology. 2000 Jul;32(1):36-42
10869286
Cochrane Database Syst Rev. 2001;(4):CD002235
11687153
Am J Med. 2002 Oct 15;113(6):506-15
12427501
J Clin Gastroenterol. 2003 Oct;37(4):336-9
14506392
Alcohol Clin Exp Res. 2003 Nov;27(11):1765-72
14634492
J Hepatol. 2004 Jan;40(1):40-6
14672612
Alcohol Res Health. 2003;27(3):220-31
15535450
Eur J Gastroenterol Hepatol. 2004 Nov;16(12):1375-80
15618848
Clin Liver Dis. 2005 Feb;9(1):67-81
15763230
J Clin Gastroenterol. 2005 Jul;39(6):520-8
15942440
Hepatology. 2005 Sep;42(3):568-77
16108051
J Hepatol. 2006 Jun;44(6):1083-8
16530878
Hepatology. 2006 Oct;44(4):788-94
17006913
Gastroenterology. 1992 Jan;102(1):200-5
1727754
Semin Liver Dis. 1991 Nov;11(4):340-8
1763339
Am J Gastroenterol. 1991 Sep;86(9):1200-8
1909085
Am J Gastroenterol. 1991 Sep;86(9):1209-18
1909086
Hepatology. 1991 Dec;14(6):1090-6
1959859
Gastroenterology. 1990 Mar;98(3):715-20
2105256
J Hepatol. 1990 Jul;11(1):92-101
2204661
Hepatology. 1986 Mar-Apr;6(2):270-4
3082733
J Hepatol. 1988 Oct;7(2):200-7
3142949
Am J Gastroenterol. 1987 Sep;82(9):871-5
3307390
Hepatology. 1985 Jan-Feb;5(1):57-63
3917968
JPEN J Parenter Enteral Nutr. 1985 Sep-Oct;9(5):590-6
3930765
J Hepatol. 1985;1(2):141-51
3932509
Lancet. 1980 Dec 13;2(8207):1276-7
6108449
Am J Med. 1984 Feb;76(2):211-22
6421159
Alcohol Clin Exp Res. 1995 Jun;19(3):635-41
7573786
J Hepatol. 1994 Oct;21(4):487-90
7814792
Gastroenterology. 1994 Jan;106(1):152-9
8276177
Hepatology. 1994 Feb;19(2):518-33
8294109
Semin Liver Dis. 1993 May;13(2):196-209
8337604
JPEN J Parenter Enteral Nutr. 1993 Mar-Apr;17(2):119-24
8455312
Annu Rev Nutr. 1996;16:321-47
8839930
Hepatology. 1997 Jun;25(6):1334-7
9185748
J Hepatol. 1998 Jan;28(1):54-60
9537864
Hepatology. 1998 Oct;28(4):901-5
9755223
Am J Gastroenterol. 1998 Nov;93(11):2022-36
9820369