title: The prevalence of live birth Down syndrome in the region of Primorsko-goranska County in Croatia, 1996-2005: the impact of screening and amniocentesis.
abstract: OBJECTIVE
  To investigate the prevalence of live birth Down syndrome (DS) in the region of Primorsko-goranska County (PGC) in Croatia from 1996 to 2005 and to evaluate the impact of second-trimester maternal serum screening (MSS) and amniocentesis on live birth DS prevalence.
  
  
  METHODS
  Study was based on databases from the Department of Gynecology and Obstetrics, University Hospital Centre Rijeka, the Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, and the Croatian National Institute of Public Health. The regional policy of prenatal diagnosis for DS includes amniocentesis for pregnant women aged 35 or over and MSS for younger women. We estimated live birth and total prevalence of DS and measured the proportion of pregnant women using MSS and amniocentesis. Trends of live birth and total prevalence of DS were tested by linear regression analysis.
  
  
  RESULTS
  The live birth prevalence of DS was 1.4/1000 in the period 1996-2005. A decreasing, but nonsignificant, trend of prevalence was observed over time (P = 0.577). Women aged 35 or over represented 11.6% of all pregnant women included in the study. The proportion of women who had MSS was 33.9%. The proportion who underwent amniocentesis was 6.1%.
  
  
  CONCLUSIONS
  No marked decrease in prevalence of live birth DS was observed in the region of PGC during the last 10 years. The usage of MSS and amniocentesis was too low to have any significant impact on live birth DS prevalence. Women's, as well as physician's, knowledge and attitudes towards prenatal diagnosis of DS should be evaluated.
authors: Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Braće Branchetta 22, Rijeka 51000, Croatia. bojana@medri.hr
authors: Bojana
authors: B
authors: Brajenović-Milić
authors: Igor
authors: I
authors: Prpić
authors: Oleg
authors: O
authors: Petrović
authors: Smiljana
authors: S
authors: Ristić
authors: Gordana
authors: G
authors: Brumini
authors: Miljenko
authors: M
authors: Kapović
mesh_terms: D000649:Amniocentesis; D017523:Croatia / Q000453:epidemiology; D004314:Down Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D016014:Linear Models; D050498:Live Birth; D008423:Maternal Age; D011295:Prenatal Care; D015995:Prevalence
references: Eur J Obstet Gynecol Reprod Biol. 2000 Jan;88(1):49-55
references: 10659916
references: BJOG. 2004 May;111(5):485-90
references: 15104615
references: BJOG. 2000 Dec;107(12):1453-9
references: 11192100
references: Eur J Hum Genet. 2001 Jan;9(1):1-4
references: 11175292
references: Rev Epidemiol Sante Publique. 2005 Nov;53 Spec No 2:2S87-95
references: 16471148
references: Prenat Diagn. 2000 Sep;20(9):709-13
references: 11015698
references: Fetal Diagn Ther. 1998 Nov-Dec;13(6):367-71
references: 9933821
references: Prenat Diagn. 1994 Sep;14(9):859-64
references: 7845894
references: Clin Chim Acta. 2002 Sep;323(1-2):1-16
references: 12135803
references: Prenat Diagn. 2005 Aug;25(8):665-70
references: 16049991
references: Prenat Diagn. 2006 Jun;26(6):499-504
references: 16634111
references: Nat Rev Genet. 2004 Oct;5(10):725-38
references: 15510164
references: Paediatr Perinat Epidemiol. 2003 Jan;17(1):33-9
references: 12562470
references: Am J Obstet Gynecol. 2004 Sep;191(3):1044-8
references: 15467587