title: Nasal continuous positive airway pressure affects pre- and postprandial intestinal blood flow velocity in preterm infants.
abstract: OBJECTIVE
  To measure the effect of nasal continuous positive airway pressure (CPAP) on intestinal blood flow velocity responses to enteral feedings and left ventricular output (LVO).
  
  
  METHODS
  Eighteen infants completed the study (birth weight 1793+/-350 g, gestational age 32.1+/-1.1 weeks). On the day infants were weaned from CPAP to room air, pre- and postprandial (0, 30, 60 and 90 min after feeding) mean velocity (MV), peak systolic velocity (PSV) and end diastolic velocity (EDV) were measured for one feeding given when receiving CPAP ('on CPAP'), and for one feeding given after CPAP had been discontinued ('off CPAP'). Preprandial LVO was measured before and after CPAP discontinuation.
  
  
  RESULTS
  MV and PSV were significantly lower when infants were on CPAP (P<0.05). Maximum postprandial MV, PSV and EDV occurred at 30 min when on CPAP and at 60 min when off CPAP. Preprandial LVO was similar when infants were on and off CPAP.
  
  
  CONCLUSIONS
  CPAP administration affects pre- and postprandial intestinal blood flow velocity, which may impact tolerance to enteral feedings.
authors: Division of Neonatology, Department of Pediatrics, University of South Florida College of Medicine, Tampa, FL, USA. thavrane@slu.edu
authors: T
authors: T
authors: Havranek
authors: C
authors: C
authors: Madramootoo
authors: J D
authors: JD
authors: Carver
mesh_terms: D001724:Birth Weight; D001783:Blood Flow Velocity / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D045422:Continuous Positive Airway Pressure; D004750:Enteral Nutrition; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology; D005865:Gestational Age; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn; D007422:Intestines / Q000098:blood supply*; D008297:Male; D017538:Mesenteric Artery, Superior / Q000000981:diagnostic imaging; D019518:Postprandial Period / Q000502:physiology*; D011446:Prospective Studies; D018617:Ultrasonography, Doppler, Pulsed; D014655:Vascular Resistance / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology