Use of antimicrobial catheter lock solutions to prevent catheter-related bacteremia.
Catheter-related bacteremia is an important source of morbidity and mortality in hemodialysis patients. A number of well-designed, controlled, prospective trials using antimicrobial catheter lock solutions to prevent catheter-related bacteremia have shown a dramatic, statistically significant decrease in not only infection but also mortality related to catheter-related bacteremia. Despite evidence of significant benefit, these locks are not routinely used in the United States. This review describes the epidemic problem of catheter-related bacteremia, reviews recent clinical trials with antimicrobial catheter lock solutions, and discusses current options and potential indications for catheter lock solutions in the hemodialysis population.
Bleyer
Anthony J
AJ
Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA. ableyer@wfubmc.edu
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016470:Bacteremia / Q000209:etiology* / Q000517:prevention & control*; D002404:Catheterization / Q000009:adverse effects*; D004866:Equipment Contamination / Q000517:prevention & control*; D006801:Humans; D006435:Renal Dialysis; D012996:Solutions / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D012996:Solutions