Expression of cancer-testis (CT) antigens in placenta.
Besides their variable presence in fetal and adult germ cells, CT antigens have occasionally been detected in placental tissue. However, these data are scarce and solely based on mRNA analyses; nothing is known about their presence at the protein level. Here, we analyzed the expression of various CT antigens in placental tissues from gestational age week 5 to week 42 using monoclonal antibodies to various antigens of the MAGE-A and -C families, NY-ESO-1, as well as GAGE. We show that CT antigen expression in placenta varies widely for the various antigens, ranging from completely negative to abundant. Since little is known about the function and biology of CT antigens, interpretation of this highly variable expression pattern is purely speculative. However, our data indicate that the various CT antigens have different functions during placental development.
Jungbluth
Achim A
AA
New York Branch, Ludwig Institute for Cancer Research, New York, NY 10021, USA. jungblua@mskcc.org
Silva
Wilson A
WA
Iversen
Kristin
K
Frosina
Denise
D
Zaidi
Bushra
B
Coplan
Keren
K
Eastlake-Wade
Susannah K
SK
Castelli
Sandra B
SB
Spagnoli
Giulio C
GC
Old
Lloyd J
LJ
Vogel
Martin
M
D000951:Antigens, Neoplasm / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008545:Melanoma / Q000378:metabolism; D058950:Melanoma-Specific Antigens; D008565:Membrane Proteins / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D010053:Ovary / Q000196:embryology / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D013737:Testis / Q000196:embryology / Q000378:metabolism; D014018:Tissue Distribution; D014327:Trophoblasts / Q000378:metabolism*
D000951:Antigens, Neoplasm; C104948:CTAG1B protein, human; C095365:GAGE1 protein, human; C072011:MAGEA1 protein, human; D058950:Melanoma-Specific Antigens; D008565:Membrane Proteins; D009363:Neoplasm Proteins
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