Foundations for directed alkaloid biosynthesis.
In this issue of Chemistry & Biology, Bernhardt and coworkers [1] assay the functional plasticity of strictosidine synthase, a gateway enzyme in the biosynthetic pathways of monoterpene indole alklaloids, and the downstream operability of the products of strictosidine synthase variants in the larger context of the plant biosynthetic pathways.
Bachmann
Brian O
BO
Department of Chemistry, Vanderbilt University, 7921 Stevenson Center, Nashville, TN 37235, USA. brian.bachmann@vanderbilt.edu
D019759:Carbon-Nitrogen Lyases / Q000378:metabolism; D002384:Catalysis; D026121:Indole Alkaloids / Q000378:metabolism*; D015202:Protein Engineering; D014748:Vinca Alkaloids / Q000096:biosynthesis
D026121:Indole Alkaloids; D014748:Vinca Alkaloids; C021093:strictosidine; D019759:Carbon-Nitrogen Lyases; C022684:strictosidine synthetase