Oral leiomyosarcomas: report of two cases with immunohistochemical profile.
Leiomyosarcoma of the oral cavity is a very rare tumor associated with aggressive clinical behavior and low survival. In this paper, we report 2 cases of leiomyosarcoma, affecting the gingival mucosa of a 54-year-old female and the maxillary bone of a 63-year-old male. Histologically, the tumors were composed of variably oriented fascicles of spindle-shaped cells with cigar-shaped nuclei and eosinophilic cytoplasm. The lesions were treated by surgical resection. Immunoreactivity to anti-vimentin, anti-smooth muscle actin, anti-desmin, anti-laminin, and anti-muscle-specific actin antibodies were found; conversely, the tumor cells were negative for anti-S100 and AE1/AE3 proteins. This report emphasizes the role of immunohistochemical study for correct diagnosis of leiomyosarcoma.
Rodini
Camila Oliveira
CO
Department of Stomatology (Oral Pathology), Dental School, University of São Paulo, São Paulo, Brazil. carodini@usp.br
Pontes
Flávia Sirotheau Corrêa
FS
Pontes
Hélder Antônio Rebelo
HA
Santos
Paulo Sérgio da Silva
PS
Magalhães
Marina Gallottini
MG
Pinto
Décio Santos
DS
D000199:Actins / Q000032:analysis; D005260:Female; D005887:Gingival Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis; D007890:Leiomyosarcoma / Q000737:chemistry* / Q000473:pathology; D008297:Male; D008441:Maxillary Neoplasms / Q000737:chemistry* / Q000473:pathology; D008875:Middle Aged
D000199:Actins; D007381:Intermediate Filament Proteins