Replication licensing: oops! ... I did it again.
All eukaryotes use multiple controls to restrict DNA replication to once per cell cycle. Nevertheless, inactivation of a single gene, cul-4, causes massive re-replication in Caenorhabditis elegans. A novel study explains this dramatic phenotype by demonstrating that the CUL-4 E3 ligase simultaneously controls two critical licensing factors: CDT-1 and CDC-6.
Korzelius
Jerome
J
Division of Developmental Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
van den Heuvel
Sander
S
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000235:genetics* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism; D004261:DNA Replication; D049751:Genome, Helminth; D008025:Ligases / Q000378:metabolism
C522445:CDC-6 protein, C elegans; D029742:Caenorhabditis elegans Proteins; C475683:Cdt-1 protein, C elegans; D018797:Cell Cycle Proteins; C475682:Cul-4 protein, C elegans; D008025:Ligases