[The drug release properties of poly (acrylamide-co-itaconate-vinylbenzylglycosylallylamide) hydrogels].
Sugar-containing monomer vinylbenzylglycosylallyamide (VBG) was synthesized by vinylbenzyl amine and delta-gluconolactone in dimethylformamide(DMF) solution. The sugar-based hydrogel was prepared by free radical crosslinking copolymerization of VBG, itaconic acid (IA) and acrylamide (AM). The release properties of Aspirin from xerogels matrices and from hydrogel in different pH solutions and different concentration NaCl solutions were studied respectively. The release mechanism of Aspirin was further confirmed by evaluating the n value in Peppas equation. The results indicated that the drug release increased with the increase of pH values and with the decrease of NaCl concentration.
Xi
Yanwei
Y
Department of Pharmacy, Shandong University, Ji'nan 250012, China.
Li
Lingbing
L
Tan
Yebang
Y
Xu
Zhenqin
Z
Li
Ying
Y
D000180:Acrylic Resins / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry; D001241:Aspirin / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D013386:Succinates / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*; D000099166:Polyacrylamides
D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D003692:Delayed-Action Preparations; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D013386:Succinates; D014753:Vinyl Compounds; D000099166:Polyacrylamides; C005229:itaconic acid