title: Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in mice.
abstract: BACKGROUND
  Aerobic conditioning improves exercise capacity and decreases symptoms in patients with asthma. However, its benefits in the context of allergic airway inflammation are poorly understood.
  
  
  OBJECTIVE
  To evaluate the effects of two intensities of aerobic exercise on airway inflammation and remodeling in a model of chronic allergic lung inflammation.
  
  
  METHODS
  Mice were subjected to chronic ovalbumin (OVA) sensitization and to 4 weeks of low (OVA+Low) or moderate (OVA+Mod) exercise training in a treadmill. Airway inflammation and remodeling and expression of helper T-cell type 1 and 2 cytokines were evaluated.
  
  
  RESULTS
  OVA-induced allergic airway inflammation and remodeling were characterized by an increase in collagen (288%), elastic fiber (56%), smooth muscle (380%), and epithelial (402%) contents (P < 0.001) when compared with the control group. OVA+Low and OVA+Mod groups presented a decrease in bronchoalveolar lavage fluid eosinophils (respectively, 84 and 75%; P < 0.01) and airway walls (respectively, 94 and 58%; P < 0.001) when compared with the OVA group. OVA+Low and OVA+Mod groups also presented a reduction in the number of peribronchial inflammatory cells expressing IL-4 (respectively, 85 and 75%; P < 0.01) and IL-5 (respectively, 88 and 89%; P < 0.01) when compared with the OVA group. Aerobic conditioning did not change the expression of either IFN-gamma or IL-2 by inflammatory cells or plasma levels of IgE or IgG1. OVA+Low and OVA+Mod groups presented an increase in the expression of IL-10 (P < 0.001). Low and moderate aerobic conditioning also reduced airway remodeling in OVA-sensitized mice when compared with the OVA group.
  
  
  CONCLUSIONS
  We concluded that low and moderate aerobic exercise decreases airway inflammation and remodeling in a murine model of asthma.
authors: Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil.
authors: Rodolfo P
authors: RP
authors: Vieira
authors: Renata C
authors: RC
authors: Claudino
authors: Anna Cecília S
authors: AC
authors: Duarte
authors: Angela B G
authors: AB
authors: Santos
authors: Adenir
authors: A
authors: Perini
authors: Hugo C C
authors: HC
authors: Faria Neto
authors: Thais
authors: T
authors: Mauad
authors: Mílton A
authors: MA
authors: Martins
authors: Marisa
authors: M
authors: Dolhnikoff
authors: Celso R F
authors: CR
authors: Carvalho
mesh_terms: D000818:Animals; D001249:Asthma / Q000378:metabolism* / Q000473:pathology* / Q000517:prevention & control; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D016207:Cytokines / Q000378:metabolism*; D004195:Disease Models, Animal; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010805:Physical Conditioning, Animal
chemical_list: D016207:Cytokines; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D010047:Ovalbumin