Deconstructing the vanilla milkshake: the dominant effect of sucrose on self-administration of nutrient-flavor mixtures.
Rats and humans avidly consume flavored foods that contain sucrose and fat, presumably due to their rewarding qualities. In this study, we hypothesized that the complex mixture of corn oil, sucrose, and flavor is more reinforcing than any of these components alone. We observed a concentration-dependent increase in reinforcers of sucrose solutions received (0%, 3%, 6.25%, and 12.5%) in both fixed ratio and progressive ratio procedures, but with equicaloric corn oil solutions (0%, 1.4%, 2.8%, and 5.6%) this finding was replicated only in the fixed ratio procedure. Likewise, addition of 1.4% oil to 3% or 12.5% sucrose increased fixed ratio, but not progressive ratio, reinforcers received relative to those of sucrose alone. Finally, addition of 3% vanilla flavoring did not change self-administration of 3% sucrose or 3% sucrose+1.4% oil solutions. These data suggest that, calorie-for-calorie, sucrose is the dominant reinforcing component of novel foods that contain a mixture of fat, sucrose, and flavor.
Naleid
Amy M
AM
Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA 98108, USA.
Grimm
Jeffrey W
JW
Kessler
David A
DA
Sipols
Alfred J
AJ
Aliakbari
Sepideh
S
Bennett
Jennifer L
JL
Wells
Jason
J
Figlewicz
Dianne P
DP
D000818:Animals; D003314:Corn Oil / Q000008:administration & dosage; D003611:Dairy Products / Q000032:analysis; D004041:Dietary Fats / Q000008:administration & dosage*; D019422:Dietary Sucrose / Q000008:administration & dosage* / Q000032:analysis; D002149:Energy Intake; D005421:Flavoring Agents / Q000008:administration & dosage*; D005518:Food Preferences; D008297:Male; D051381:Rats; D012646:Self Administration; D012996:Solutions; D031669:Vanilla / Q000737:chemistry*
D004041:Dietary Fats; D019422:Dietary Sucrose; D005421:Flavoring Agents; D012996:Solutions; D003314:Corn Oil
Life Sci. 2000;67(2):197-204
10901287
Eur J Clin Nutr. 1996 Jul;50(7):418-30
8862477
Crit Rev Food Sci Nutr. 2000 Nov;40(6):481-515
11186237
J Gerontol A Biol Sci Med Sci. 2001 Apr;56(4):M200-5
11283191
Physiol Behav. 2001 May;73(1-2):229-34
11399316
Am J Clin Nutr. 2002 Oct;76(4):721-9
12324283
J Nutr. 2003 Mar;133(3):831S-834S
12612162
Lipids. 2003 Feb;38(2):109-15
12733741
Biosci Biotechnol Biochem. 2003 Aug;67(8):1683-90
12951500
Appetite. 2004 Apr;42(2):139-42
15010177
Behav Neurosci. 2004 Jun;118(3):479-87
15174925
Physiol Behav. 2004 Jun;81(4):699-713
15178165
Alcohol Clin Exp Res. 1997 Apr;21(2):250-60
9113261
J Am Diet Assoc. 1997 Jul;97(7 Suppl):S63-9
9216571
Pharmacol Biochem Behav. 1997 Jul;57(3):441-7
9218268
Psychopharmacology (Berl). 1997 Aug;132(4):350-60
9298512
Appetite. 1998 Dec;31(3):333-49
9920686
Science. 1961 Sep 29;134(3483):943-4
13714876
Physiol Behav. 2005 Jan 31;84(1):73-9
15642609
Physiol Behav. 2006 Aug 30;89(1):62-5
16516250
Physiol Behav. 2006 Oct 30;89(3):414-9
16904138
Appetite. 2007 Jan;48(1):29-36
16914226
Peptides. 2000 Sep;21(9):1361-7
11072123
J Am Diet Assoc. 2004 Jul;104(7):1151-3
15215775
Physiol Behav. 2004 Jul;81(5):773-9
15234183
Neurosci Biobehav Rev. 1987 Summer;11(2):231-40
3614791
Physiol Behav. 1990 Jan;47(1):51-5
2326345
Am J Clin Nutr. 1990 Jun;51(6):963-9
2349932
Appetite. 1990 Dec;15(3):171-88
2281948
Appetite. 1990 Dec;15(3):189-97
2281949
Synapse. 1992 Mar;10(3):247-63
1557697
Physiol Behav. 1993 Feb;53(2):395-402
8446704
Am J Clin Nutr. 1993 May;57(5 Suppl):772S-777S; discussion 777S-778S
8475895
Physiol Behav. 1994 Aug;56(2):331-7
7938246
J Neurosci Methods. 1996 May;66(1):1-11
8794935
Am J Clin Nutr. 2007 Mar;85(3):651-61
17344485