Exploring effects of different nonsteroidal antiinflammatory drugs on lipid peroxidation. Part II. 4-HNE profile.
Non-steroidal anti-inflammatory drugs (NSAIDs) are common in alleviating pain, pyrexia and inflammation, in patients with rheumatoid arthritis and osteoarthritis. As these drugs are associated with high incidence of gastrointestinal ulceration, bleeding and kidney damage which may be linked with lipid peroxidation. our study was aimed to examine lipid peroxidation induction capacity of NSAIDs (diclofenac sodium, ibuprofen, flurbiprofen, paracetamol, nimesulide, celecoxib and indomethacin) by determining 4-hydroxy-2-nonenal (4-HNE) concentration as an index of lipid peroxidation and to see the suppressive potential of ascorbic acid on NSAID induced lipid peroxidation. The results suggest that diclofenac sodium, ibuprofen, flurbiprofen, paracetamol, nimesulide and celecoxib exerted mild antioxidant activity. Indomethacin exerted statistically significant increase in 4-HNE content, indicating statistically significant peroxidation activity. Ascorbic acid could significantly reduce indomethacin-induced lipid peroxidation.
Chakraborty
Santanu
S
Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata - 700 032, India.
Roy
Kunal
K
Sengupta
Chandana
C
D000082:Acetaminophen / Q000009:adverse effects; D000447:Aldehydes / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D000068579:Celecoxib; D004008:Diclofenac / Q000009:adverse effects; D005480:Flurbiprofen / Q000009:adverse effects; D006041:Goats; D007052:Ibuprofen / Q000009:adverse effects; D007213:Indomethacin / Q000009:adverse effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D011720:Pyrazoles / Q000009:adverse effects; D013449:Sulfonamides / Q000009:adverse effects
D000447:Aldehydes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D011720:Pyrazoles; D013449:Sulfonamides; D004008:Diclofenac; D000082:Acetaminophen; D005480:Flurbiprofen; D000068579:Celecoxib; C027576:4-hydroxy-2-nonenal; D001205:Ascorbic Acid; C012655:nimesulide; D007052:Ibuprofen; D007213:Indomethacin