[An experimental study of energy controllable steep pulse in the treatment of rat with subcutaneous transplantive tumor].
This experimental study was designed to investigate the effects and the expressions of microvessel density (MVD), vascular endothelial growth factor (VEGF) on the transplanted tumor in the rat model with Walker-256 after energy controllable steep pulse(ECSP). The experiment revealed that the steep pulse electrical field has better effect on tumor, compared with the control. The positive cell staining intensity of VEGF in the control group was significantly higher than that in ECSP group (P < 0.05). The number of MVD in the tumor tissues of ECSP group was significantly lower than that of tumor control group (P < 0.05). These results showed that ECSP could inhibit the growth and angiogenesis of tumor and its pathway is to down-regulate the expression of VEGF possibly.
Luo
Xiaodong
X
Department of Obstetrics and Gynecology, The Second Affilate Hospital, Chongqing University of Medical Science, Chongqing 400010, China.
Hu
Li'na
L
Sun
Caixin
C
Xiong
Lan
L
Mi
Yan
Y
D000818:Animals; D002279:Carcinoma 256, Walker / Q000098:blood supply / Q000628:therapy*; D004553:Electric Conductivity; D004599:Electric Stimulation Therapy / Q000379:methods*; D004574:Electromagnetic Fields; D018274:Electroporation / Q000379:methods; D005260:Female; D008297:Male; D009389:Neovascularization, Pathologic; D051381:Rats; D017208:Rats, Wistar; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D042461:Vascular Endothelial Growth Factor A