Pharmacokinetics of astragaloside iv in beagle dogs.
In this study, the pharmacokinetics of Astragaloside iv (AGS-IV) in Beagle dogs was studied by high performance liquid chromatography (HPLC) coupled with tandem mass spectrometry (MS). The concentrations of the drugs in plasma were determined after i.v. administration of 0.5, 1, 2 mg.kg(-1) AGS-IV and p.o. administration of 10 mg.kg(-1) AGS-IV. The areas under concentration-time curve (AUC) were linearly correlated to the doses administrated. The absolute bioavailability of AGS-IV after p.o. administration was found to be 7.4%. The plasma protein binding rate of AGS-IV was about 90% within a concentration range of 250-1000 ng.ml(-1). There was no significant species difference regarding the pharmacokinetics of AGS-IV between the rat and the Beagle dog.
Zhang
Qi
Q
College of Life Science and Pharmacy, Nanjing University of Technology, Nanjing, People's Republic of China. zqapple@126.com
Zhu
Ling-Ling
LL
Chen
Guo-Guang
GG
Du
Yu
Y
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D011485:Protein Binding; D051381:Rats; D015203:Reproducibility of Results; D012503:Saponins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013045:Species Specificity; D053719:Tandem Mass Spectrometry; D014315:Triterpenes / Q000008:administration & dosage / Q000493:pharmacokinetics*
D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C052064:astragaloside A
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