title: Lipoprotein-associated phospholipase A(2) : review of its role as a marker and a potential participant in coronary endothelial dysfunction.
abstract: The role of inflammation in atherosclerosis continues to emerge. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), a novel plasma biomarker, circulates in the blood bound mainly to low-density lipoprotein (LDL) and promotes vascular inflammation. Several epidemiological studies have shown that circulating levels of Lp-PLA(2) are an independent risk factor for cardiovascular events. Recent studies demonstrate that Lp-PLA(2) is also associated with endothelial dysfunction and early atherosclerosis. This review provides an overview of these studies, suggests plausible mechanisms for the association between endothelial dysfunction and Lp-PLA(2), and highlights future potential therapies.
authors: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors: Shahar
authors: S
authors: Lavi
authors: Ronit
authors: R
authors: Lavi
authors: Joseph P
authors: JP
authors: McConnell
authors: Lilach O
authors: LO
authors: Lerman
authors: Amir
authors: A
authors: Lerman
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D003327:Coronary Disease / Q000201:enzymology* / Q000503:physiopathology* / Q000628:therapy; D004730:Endothelium, Vascular / Q000201:enzymology* / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation
chemical_list: D015415:Biomarkers; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase
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