Cyclonatsudamine A, a new vasodilator cyclic peptide from Citrus natsudaidai.
A new cyclic heptapeptide, cyclonatsudamine A (1), cyclo (-Gly-Tyr-Leu-Leu-Pro-Pro-Ser-), has been isolated from the peels of Citrus natsudaidai and the structure was elucidated by 2D NMR analysis and chemical degradation. Cyclonatsudamine A (1) relaxed norepinephrine-induced contractions of rat aorta, which may be mediated through the increased release of NO from endothelial cells.
Morita
Hiroshi
H
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan. moritah@hoshi.ac.jp
Enomoto
Maiko
M
Hirasawa
Yusuke
Y
Iizuka
Toru
T
Ogawa
Kazunori
K
Kawahara
Nobuo
N
Goda
Yukihiro
Y
Matsumoto
Teruki
T
Takeya
Koichi
K
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002957:Citrus / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009010:Monte Carlo Method; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D014662:Vasoconstrictor Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014665:Vasodilator Agents / Q000302:isolation & purification* / Q000494:pharmacology*
D010456:Peptides, Cyclic; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; C524324:cyclonatsudamine A; D009638:Norepinephrine