title: Diversity and relationship between Iranian ethnic groups: human dopamine transporter gene (DAT1) VNTR genotyping.
abstract: The 40-bp VNTR polymorphism in the 3' untranslated region of the human DAT1 (dopamine transporter 1) was analyzed in the Iranian ethnic groups in order to examine the influence of geographical and linguistic affiliation on the genetic affinities among the Iranian population. A total of 449 subjects belonging to nine ethnic groups from the Iranian population were included in the study. The screening of 898 chromosomes showed five alleles (6, 7, 8, 9, 10, and 11), of which allele 10 revealed the highest frequency in most regions. Allele 8 was predominant in one ethnicity and occurred more frequently in the center of Iran. This study shows that the DAT1 distribution in Iran has a different pattern from those in other studies, which can contribute to an understanding of differentiation and diversity of Iranian ethnic groups. This polymorphism could represent the genetic diversity among the various ethnic groups of Iran.
authors: Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran. mmbanoei@yahoo.com
authors: Mohammad Mehdi
authors: MM
authors: Banoei
authors: Morteza Hashemzadeh
authors: MH
authors: Chaleshtori
authors: Mohammah Hossein
authors: MH
authors: Sanati
authors: Mehdi Shafa Sharait
authors: MS
authors: Panahi
authors: Tayebeh
authors: T
authors: Majidizadeh
authors: Maryam
authors: M
authors: Rostami
authors: Massoumeh Dehghan
authors: MD
authors: Manshadi
authors: Masoud
authors: M
authors: Golalipour
mesh_terms: D003710:Demography; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D005843:Geography; D006801:Humans; D007492:Iran; D018598:Minisatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic; D012494:Sampling Studies
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins