title: Low-dose ginseng (Panax quinquefolium) modulates the course and magnitude of the antibody response to vaccination against equid herpesvirus I in horses.
abstract: The purpose of this study was to determine if ginseng fed at low levels enhances a horse's antibody response to vaccination against Equid herpesvirus 1 (EHV-1). For 28 d, 5 horses received ground, powdered ginseng (35 mg/kg body weight, 1.7 mg/kg total ginsenosides) in molasses as a carrier, and 5 received molasses only. On day 14, each horse was vaccinated against EHV-1. The time course of the antibody response to vaccination was significantly altered in the horses receiving ginseng, a clinically relevant increase in antibody titer being observed by postvaccination day 2 compared with day 6 in the control horses. The horses receiving ginseng also had a significant decrease in serum levels of sodium and a significant increase in serum levels of potassium. No adverse effects of ginseng treatment were identified by hematologic and blood biochemistry profiles. Thus, low-dose dietary supplementation with ginseng in healthy horses may be a useful adjunct to vaccination.
authors: Equine Research Centre, University of Guelph, Guelph, Ontario. wpearson@uoguelph.ca
authors: Wendy
authors: W
authors: Pearson
authors: Semir
authors: S
authors: Omar
authors: Andrew F
authors: AF
authors: Clarke
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D006566:Herpesviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D004861:Herpesvirus 1, Equid / Q000276:immunology*; D022283:Herpesvirus Vaccines / Q000276:immunology*; D006734:Horse Diseases / Q000517:prevention & control*; D006736:Horses; D008297:Male; D005894:Panax / Q000276:immunology*; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D014611:Vaccination / Q000379:methods / Q000662:veterinary
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D022283:Herpesvirus Vaccines; D012964:Sodium; D011188:Potassium
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