title: Polymorphisms of apolipoprotein e and methylenetetrahydrofolate reductase in the Japanese population.
abstract: OBJECTIVE
  The aim of this study is to analyze the effect of apolipoprotein E (apo E) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms on serum lipid and homocysteine levels in the general Japanese population.
  
  
  METHODS
  We analyzed the polymorphisms in individuals randomly selected from among participants of Serum Lipid Survey 2000.
  
  
  RESULTS
  The frequency of the epsilon2, epsilon3, and epsilon4 alleles of APOE was 4.2, 85.3, and 10.5%, respectively. Individuals with the genotype epsilon4/epsilon4 had the highest total and low-density lipoprotein (LDL) cholesterol levels, while those with epsilon2/epsilon2 had the lowest. Individuals with the epsilon2/epsilon2 and epsilon2/epsilon4 genotypes had higher remnant-like particles (RLP)-cholesterol levels than those with epsilon2epsilon3, epsilon3epsilon3, and epsilon3epsilon4. There was a trend for individuals with the epsilon2/epsilon4 and epsilon2/epsilon2 genotypes to have higher triglyceride levels, although the difference was not significant. The presence of the T allele in a MTHFR polymorphism (C667T) was associated with higher homocysteine levels, which is more prominent in men than in women.
  
  
  CONCLUSIONS
  Thus in our large-scale analysis we have shown that RLP-cholesterol is better associated with, APOE genotype than triglyceride and the effect of the T allele on MTHFR polymorphism (C667T) homocysteine levels is more prominent in men than in women among Japanese.
authors: Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, Japan. harai@kuhp.kyoto-u.ac.jp
authors: Hidenori
authors: H
authors: Arai
authors: Akira
authors: A
authors: Yamamoto
authors: Yuji
authors: Y
authors: Matsuzawa
authors: Yasushi
authors: Y
authors: Saito
authors: Nobuhiro
authors: N
authors: Yamada
authors: Shinichi
authors: S
authors: Oikawa
authors: Hiroshi
authors: H
authors: Mabuchi
authors: Tamio
authors: T
authors: Teramoto
authors: Jun
authors: J
authors: Sasaki
authors: Noriaki
authors: N
authors: Nakaya
authors: Hiroshige
authors: H
authors: Itakura
authors: Yuichi
authors: Y
authors: Ishikawa
authors: Yasuyoshi
authors: Y
authors: Ouchi
authors: Hiroshi
authors: H
authors: Horibe
authors: Tohru
authors: T
authors: Egashira
authors: Hiroaki
authors: H
authors: Hattori
authors: Toru
authors: T
authors: Kita
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D003625:Data Collection; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology / Q000235:genetics*; D006949:Hyperlipidemias / Q000453:epidemiology / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D017678:Sex Distribution
chemical_list: D001057:Apolipoproteins E; D008055:Lipids; D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2)