title: Analysis of C-850T and G-308A polymorphisms of the tumor necrosis factor-alpha gene in Maya-Mestizo women with preeclampsia.
abstract: OBJECTIVE
  To determine whether polymorphisms in the TNF-alpha promoter gene are associated with preeclampsia.
  
  
  METHODS
  105 women with preeclampsia and 200 controls were genotyped for the G-308A and C-850T polymorphisms by RFLP. Differences in allele, genotype, and haplotype frequencies between groups were assessed.
  
  
  RESULTS
  The genotypic and allelic distribution of both polymorphisms was similar between groups. Moreover, the estimated overall pair of loci haplotype frequencies did not differ significantly.
  
  
  CONCLUSIONS
  We did not find any association between these polymorphisms and the risk for preeclampsia. However, we found that both the genotypic and allelic distribution in our population differed from those reported in other populations.
authors: Laboratorio de Biología de la Reproducción, Departamento de Salud Reproductiva y Genética, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Mérida, Yucatán, México.
authors: Thelma
authors: T
authors: Canto-Cetina
authors: Samuel
authors: S
authors: Canizales-Quinteros
authors: Elsa
authors: E
authors: de la Chesnaye
authors: Ramón
authors: R
authors: Coral-Vázquez
authors: Juan Pablo
authors: JP
authors: Méndez
authors: Patricia
authors: P
authors: Canto
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007198:Indians, North American; D008800:Mexico; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000208:ethnology / Q000235:genetics*; D011247:Pregnancy; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha