Beat shock proteins and atrial fibrillation.
In this mini-review, the role of heat shock proteins in susceptability to induction of atrial fibrillation (AF) or in the process of AF is discussed. AF is the most common arrhythmia in humans, is self-perpetuating in nature and hence tends to become more persistent in time. Some studies show a correlation between high Hsp70 (HspA1A) expression in cardiac tissue and a reduced susceptability to induction of postoperative AF. Expression of Hsp70, Hsc70 (HspA8), Hsp40 (DnaJB1), Hsp60 (HspD1), Hsp90 (HspC1) was not associated with progression of AF. However, both correlative studies in human and experimental studies suggest that Hsp27 (HspB1) may delay progression of AF to the more permanent forms and hence Hsp27 might be referred to as a "Beat shock protein".
Kampinga
Harm H
HH
Department of Cell Biology, Clinical Pharmacology, and Cardiology, University Medical Center Groningen and University of Groningen, The Netherlands. h.h.kampinga@med.umcg.nl
Henning
Robert H
RH
van Gelder
Isabelle C
IC
Brundel
Bianca J J M
BJ
D001281:Atrial Fibrillation / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans
D006360:Heat-Shock Proteins
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