Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats.
Previous studies have suggested that intermittent exposure to hydrogenated vegetable shortening yields a binge/compensate pattern of feeding in rats. The present study was designed to assess whether rats would exhibit similar patterns of intake when given intermittent access to a nutritionally complete high-fat diet. Four groups of rats received varying exposure to either hydrogenated vegetable shortening or high-fat diet for 8 consecutive weeks. Animals were given daily and intermittent access to determine if the binge/compensate pattern of feeding was frequency dependent. At the conclusion of the study, body composition and plasma leptin levels were assessed to determine effects of diet and binge/compensate intake on endocrine alterations. As predicted, animals receiving intermittent access to high-fat diet displayed the binge/compensate pattern of feeding and appeared to compensate as a result of the caloric overload accompanying a particular binge episode. In addition, exposure to either shortening or high-fat diet led to alterations in body composition, while only exposure to shortening altered plasma leptin levels. These results suggest that binge-intake behavior occurs on a nutritionally complete high-fat diet and that this regimen is capable of altering both body composition and endocrine profile.
Davis
Jon F
JF
University of Cincinnati, Department of Psychiatry, ML # 0506, Reading, OH 45237, United States. Jon.Davis@uc.edu
Melhorn
Susan J
SJ
Shurdak
Jennifer D
JD
Heiman
Justin U
JU
Tschöp
Matthias H
MH
Clegg
Deborah J
DJ
Benoit
Stephen C
SC
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002032:Bulimia / Q000503:physiopathology* / Q000523:psychology*; D004041:Dietary Fats / Q000008:administration & dosage*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D002149:Energy Intake / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects* / Q000523:psychology; D020738:Leptin / Q000097:blood; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans
D004041:Dietary Fats; D020738:Leptin
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