Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.
Catechol-O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an ethologically based approach, the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing. Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1.
Babovic
Daniela
D
Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
O'Tuathaigh
Colm M
CM
O'Sullivan
Gerard J
GJ
Clifford
Jeremiah J
JJ
Tighe
Orna
O
Croke
David T
DT
Karayiorgou
Maria
M
Gogos
Joseph A
JA
Cotter
David
D
Waddington
John L
JL
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002394:Catechol O-Methyltransferase / Q000172:deficiency*; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D006185:Habituation, Psychophysiologic / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000235:genetics; D010641:Phenotype
D002394:Catechol O-Methyltransferase