title: Establishing causality in pediatric adverse drug reactions: use of the Naranjo probability scale.
abstract: Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition. Its diagnosis is critical to avoid future exposure to aromatic anticonvulsants. Pediatricians rarely use a systematic approach to establish the cause of drug reactions in the clinical setting. We describe the use of the Naranjo adverse drug reaction probability scale to establish causality in three cases of suspected anticonvulsant hypersensitivity syndrome with the aim of introducing clinicians to this effective tool. Our analysis reveals that this method is useful, but also highlights potential areas for its improvement.
authors: Division of Clinical Pharmacology/Toxicology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
authors: Marina
authors: M
authors: Avner
authors: Yaron
authors: Y
authors: Finkelstein
authors: Dan
authors: D
authors: Hackam
authors: Gideon
authors: G
authors: Koren
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D015984:Causality; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D010818:Practice Patterns, Physicians'; D011336:Probability; D012640:Seizures / Q000188:drug therapy; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013577:Syndrome
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine
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