The VEGF family, the inside story.
The role of paracrine signaling by vascular endothelial growth factor (VEGF) in the formation and maintenance of blood vessels has been studied extensively. In this issue, Lee et al. (2007) report unexpected results showing that endogenous VEGF produced by endothelial cells is also crucial for vascular homeostasis.
Heloterä
Hanna
H
Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Biomedicum Helsinki, P.O.B. 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland.
Alitalo
Kari
K
D000818:Animals; D019898:Autocrine Communication; D002196:Capillaries / Q000254:growth & development; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D019899:Paracrine Communication; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000502:physiology*
D042461:Vascular Endothelial Growth Factor A