[Study on mechanism of biminne in treating allergic rhinitis].
OBJECTIVE
To investigate the effect and mechanism of Biminne, a Chinese herbal compound preparation, for treatment of allergic rhinitis (AR).


METHODS
AR model of mouse was induced by intraperitoneal injection of ovalbumin (OVA), and the changes in behavior, proliferative activity of splenic lymphocyte, serum levels of total IgE and OVA specific IgE were observed.


RESULTS
Biminne showed effects in reducing the frequency of sneezing and nasal rubbing, inhibiting the proliferation of splenic lymphocyte stimulated by phyto-hemagglutinin (PHA) and OVA, and lowering the levels of serum total IgE and OVA specific IgE.


CONCLUSIONS
Biminne could inhibit the proliferation of splenic lymphocyte and reduce serum level of IgE in mice with AR.
Liu
Run-hong
RH
Institute of Integrated Traditional Chinese and Western Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai.
Zhang
Xin-min
XM
Zhang
Su-qin
SQ
D000818:Animals; D049109:Cell Proliferation; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007073:Immunoglobulin E / Q000097:blood; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin; D008517:Phytotherapy; D011897:Random Allocation; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology
D004365:Drugs, Chinese Herbal; D007073:Immunoglobulin E; D010047:Ovalbumin