[Expression of pJAK, pERK and Cyclin D1 proteins in squamous-cell carcinoma of tongue].
To investigate the expression of JAK, ERK and Cyclin D proteins in squamous-cell carcinoma of tongue.



The expression of JAK, ERK and Cyclin D1 proteins was determined with SP immunohistochemical method in 30 cases of lingual Squamous cell carcinoma, 20 of normal lingual mucosa, 10 of mild epithelial dysplasia and 20 of severe epithelial dysplasia.



The expression of pJAK in lingual squamous-cell carcinoma and epithelial dysplasia was stronger than that of normal lingual mucosa (chi2=37.54, P<0.01), and the expression of pJAK in lingual squamous-cell carcinoma was significantly higher than that of the epithelial dysplasia (chi2=6.83, P<0.05). pJAK expression in squamous-cell carcinoma of low-middle differentiation was stronger than that of high differentiation. There was no significant difference in pERK expression among lingual squamous-cell carcinoma, normal lingual mucosa and epithelial dysplasia. There was a significantly positive correlation between pJAK and Cyclin D1 expression in SCC (r=0.619, P<0.05). There was no significant correlation between the expression of pERK and Cyclin D1 (r=0.231, P>0.05).



Over-expression of pJAK and Cyclin D1 may be associated with the occurrence and development of squamous-cell carcinoma of the tongue.
Li
Song-ying
SY
The Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University, Hangzhou 310006, China. lsy@zju.edu.cn
Dai
Jie
J
Hu
Ji-an
JA
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000378:metabolism*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D053612:Janus Kinases / Q000378:metabolism*; D010766:Phosphorylation; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000473:pathology
D019938:Cyclin D1; D053612:Janus Kinases; D048049:Extracellular Signal-Regulated MAP Kinases