title: [Therapeutic drug monitoring in epileptology and psychiatry].
abstract: Experts from epileptology and psychiatry reviewed the current significance of therapeutic drug monitoring (TDM) of antiepileptic drugs and psychiatric drugs in a workshop at Bethel Epilepsy Centre in December 2005. TDM has been essential in epileptology for about 30 years, and it is also increasingly important in psychiatry, in which consensus recommendations were published recently. With regard to cost-cutting in the health system, there are discussions about the financial effect of TDM and outsourcing it to bigger laboratories. In psychiatry it has however been shown that sensibly used TDM may lead to reduced costs. Many issues in TDM require the knowledge and experience of specialised laboratories. The use of TDM data for scientific purposes was discussed at the workshop as well.
authors: Evangelisches Krankenhaus, Epilepsiezentrum Bethel (Kliniken), Maraweg 21, Bielefeld, Germany. christian.brandt@evkb.de
authors: C
authors: C
authors: Brandt
authors: P
authors: P
authors: Baumann
authors: G
authors: G
authors: Eckermann
authors: C
authors: C
authors: Hiemke
authors: T W
authors: TW
authors: May
authors: B
authors: B
authors: Rambeck
authors: B
authors: B
authors: Pohlmann-Eden
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D003362:Cost-Benefit Analysis; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000191:economics*; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005858:Germany; D006801:Humans; D001523:Mental Disorders / Q000097:blood* / Q000188:drug therapy; D009313:National Health Programs / Q000191:economics*; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*
chemical_list: D000927:Anticonvulsants; D011619:Psychotropic Drugs
references: Int J Neuropsychopharmacol. 1999 Mar;2(1):17-23
references: 11281966
references: Mutat Res. 2001 Oct 1;482(1-2):11-9
references: 11535244
references: Soc Psychiatry Psychiatr Epidemiol. 1995 Aug;30(5):196-205
references: 7482004
references: Eur J Clin Pharmacol. 1997;51(6):481-4
references: 9112063
references: J Pharm Pharmacol. 2004 Aug;56(8):967-75
references: 15285840
references: Pharmacopsychiatry. 1991 Nov;24(6):190-5
references: 1812496
references: Clin Pharmacokinet. 2006;45(11):1061-75
references: 17048972
references: J Clin Psychiatry. 1991 Jun;52 Suppl:23-33
references: 1904862
references: Am J Psychiatry. 2004 May;161(5):826-35
references: 15121647
references: Br J Clin Pharmacol. 2006 Feb;61(2):191-9
references: 16433873
references: Epilepsy Behav. 2003 Oct;4(5):487-95
references: 14527489
references: Pharmacopsychiatry. 2002 Mar;35(2):50-6
references: 11985287
references: Epilepsy Res. 2001 Nov;47(1-2):151-4
references: 11673029
references: Acta Psychiatr Scand. 2001 Sep;104(3):173-92
references: 11531654
references: Br J Clin Pharmacol. 2002 Feb;53(2):111-22
references: 11851634
references: Drug Saf. 2006;29(9):735-68
references: 16944962
references: J Clin Psychopharmacol. 2001 Oct;21(5):500-15
references: 11593076
references: Ther Drug Monit. 2004 Oct;26(5):582
references: 15385844
references: Am J Psychiatry. 2002 Jan;159(1):103-8
references: 11772697
references: Pharmacogenomics. 2002 Mar;3(2):201-18
references: 11972442
references: Clin Pharmacol Ther. 2004 Jan;75(1):13-33
references: 14749689
references: Ther Drug Monit. 2006 Feb;28(1):83-8
references: 16418699
references: Psychopharmacology (Berl). 1982;78(1):25-7
references: 6815692
references: J Clin Psychopharmacol. 2005 Aug;25(4):342-8
references: 16012277
references: J Clin Psychiatry. 1999;60 Suppl 1:4-6; discussion 28-30
references: 10037163
references: Acta Psychiatr Scand. 2000 May;101(5):354-9
references: 10823294
references: Lancet. 2000 Nov 11;356(9242):1667-71
references: 11089838
references: Dtsch Med Wochenschr. 1991 Apr 19;116(16):631-3
references: 2015781
references: Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):69-77
references: 14598019
references: Pharmacopsychiatry. 2004 Nov;37(6):243-65
references: 15551191
references: Biopharm Drug Dispos. 1999 Nov;20(8):369-77
references: 10870093
references: J Pharm Biomed Anal. 2004 Sep 3;35(5):1203-12
references: 15336365
references: Ther Drug Monit. 1999 Apr;21(2):175-81
references: 10217337
references: J Clin Psychopharmacol. 2001 Jun;21(3):305-10
references: 11386494
references: Trends Pharmacol Sci. 2004 Aug;25(8):423-9
references: 15276711
references: Ther Drug Monit. 2004 Apr;26(2):156-60
references: 15228157
references: Neurology. 2004 Sep 28;63(6):1022-6
references: 15452293
references: J Clin Psychopharmacol. 2006 Dec;26(6):671-3
references: 17110832