title: Total syntheses of brominated marine sponge alkaloids.
abstract: Total syntheses of six brominated marine sponge bis(indole) alkaloids of the hamacanthin, spongotine, and topsentin classes are described. Retrosynthetic analysis shows that their structures all include the 1-(6'-bromoindol-3'-yl)-1,2-diaminoethane unit 13a. This key moiety has been prepared from brominated indolic N-hydroxylamine 5b via synthetic intermediate 8b.
authors: Département de Chimie Moléculaire (SERCO), UMR-5250, ICMG FR-2607, CNRS, Université Joseph Fourier, BP-53, 38041 Grenoble Cedex 9, France.
authors: Xavier
authors: X
authors: Guinchard
authors: Yannick
authors: Y
authors: Vallée
authors: Jean-Noël
authors: JN
authors: Denis
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D000818:Animals; D001966:Bromine / Q000737:chemistry*; D015394:Molecular Structure; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D001966:Bromine