title: Design and synthesis of thiazoline-thiazole hybrid macrocycles possessing strong binding affinity to Pb2+ and Cd2+.
abstract: Thiazoline-thiazole hybrid macrocycles were synthesized via head-to-tail cyclooligomerization. The macrocycle consisting of eight heterocyclic subunits displays high binding affinity to the heavy metal toxins Pb(2+) and Cd(2+).
authors: PRESTO, The Japan Science and Technology Agency (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
authors: Fu She
authors: FS
authors: Han
authors: Hidetoshi
authors: H
authors: Tokuyama
authors: Tohru
authors: T
authors: Fukuyama
mesh_terms: D002104:Cadmium / Q000737:chemistry*; D002413:Cations, Divalent; D015195:Drug Design; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006860:Hydrogen Bonding; D007854:Lead / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis* / Q000737:chemistry; D019216:Metals, Heavy / Q000737:chemistry; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D053778:Thiazolidines / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D002413:Cations, Divalent; D006571:Heterocyclic Compounds; D046911:Macromolecular Substances; D019216:Metals, Heavy; D013844:Thiazoles; D053778:Thiazolidines; D002104:Cadmium; D007854:Lead