Neurodevelopmental outcome of children with intrauterine growth retardation: a longitudinal, 10-year prospective study.
One hundred twenty-three children with intrauterine growth retardation were prospectively followed from birth to 9 to 10 years of age in order to characterize their specific neurodevelopmental and cognitive difficulties and to identify clinical predictors of such difficulties. Perinatal biometric data and risk factors were collected. Outcome was evaluated at age 9 to 10 by neurodevelopmental, cognitive, and school achievement assessments. Sixty-three children served as controls who were appropriate for gestational age. Significant differences in growth (P < .001), neurodevelopmental scores (P < .001), intelligence quotient (IQ) (P < .0001), and school achievements measured by the Kaufmann Assessment Battery for Children (P < .001) were found between the children with intrauterine growth retardation and controls. Children with intrauterine growth retardation demonstrated a specific profile of neurocognitive difficulties at school age, accounting for lower school achievements. The best perinatal parameter predictive of neurodevelopment and IQ was the Cephalization Index (P < .001). Somatic catch-up growth at age 2 and at age 9 to 10 correlated with favorable outcome at 9 to 10 years of age.
Leitner
Yael
Y
Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv University, Israel.
Fattal-Valevski
Aviva
A
Geva
Ronny
R
Eshel
Rina
R
Toledano-Alhadef
Hagit
H
Rotstein
Michael
M
Bassan
Haim
H
Radianu
Bella
B
Bitchonsky
Ora
O
Jaffa
Ariel J
AJ
Harel
Shaul
S
D001699:Biometry / Q000379:methods; D016022:Case-Control Studies; D002648:Child; D003072:Cognition Disorders / Q000209:etiology*; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000145:classification / Q000503:physiopathology* / Q000523:psychology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors