Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses.
Recently it has been shown by several laboratories that the influenza A virus nonstructural protein 1 (A/NS1) binds and activates phosphatidylinositol 3-kinase (PI3K). This function of the protein is likely to prevent premature apoptosis induction during viral propagation. Here we show that the B/NS1 protein completely lacks the capacity to induce PI3K signaling. Thus, PI3K activation is another unique function of A/NS1 that is different from the action of its influenza B virus counterpart.
Ehrhardt
Christina
C
Institute of Molecular Virology (IMV), ZMBE, Westfaelische-Wilhelms-University, Von Esmarch-Strasse 56, D-48149 Muenster, Germany.
Wolff
Thorsten
T
Ludwig
Stephan
S
D000818:Animals; D017209:Apoptosis; D002522:Chlorocebus aethiops; D004285:Dogs; D004789:Enzyme Activation; D015967:Gene Expression Regulation, Viral; D009980:Influenza A virus / Q000378:metabolism*; D009981:Influenza B virus / Q000378:metabolism*; D008957:Models, Genetic; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction; D013045:Species Specificity; D014709:Vero Cells; D017361:Viral Nonstructural Proteins / Q000378:metabolism*
D019869:Phosphatidylinositol 3-Kinases; D017361:Viral Nonstructural Proteins; C085820:INS1 protein, influenza virus
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4309-14
10725408
Apoptosis. 2007 Aug;12(8):1419-32
17468837
Trends Mol Med. 2003 Feb;9(2):46-52
12615037
J Virol. 2004 Feb;78(4):1865-72
14747551
FEBS Lett. 2004 Jun 4;567(2-3):230-8
15178328
Cell. 2004 Aug 6;118(3):274-6
15294152
Curr Top Microbiol Immunol. 2004;283:249-80
15298172
Virology. 1996 Sep 1;223(1):41-50
8806538
EMBO J. 1996 Dec 2;15(23):6541-51
8978681
Virology. 1998 Dec 20;252(2):324-30
9878611
Nat Struct Mol Biol. 2004 Nov;11(11):1060-7
15502848
Cell Microbiol. 2006 Mar;8(3):375-86
16469051
Cell Microbiol. 2006 Aug;8(8):1336-48
16882036
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14194-9
16963558
Oncogene. 2006 Oct 30;25(51):6844-67
17072332
Science. 2006 Nov 10;314(5801):997-1001
17038589
J Virol. 2006 Dec;80(23):11667-77
16987984
J Gen Virol. 2007 Jan;88(Pt 1):13-8
17170431
J Virol. 2007 Jan;81(2):514-24
17079289
J Virol. 2007 Apr;81(7):3058-67
17229704
Biochem Soc Trans. 2007 Apr;35(Pt 2):186-7
17371234
Cell Microbiol. 2007 Apr;9(4):930-8
17140406
Annu Rev Biochem. 2001;70:535-602
11395417