title: Long chain omega-3 fatty acids intake, fish consumption and mental disorders in the SUN cohort study.
abstract: BACKGROUND
  Very long chain omega-3 fatty acids (w-3 PUFA) intake and fish consumption have been suggested as protective factors against neuropsychiatric disorders but there is scarcity of large cohort studies assessing this association.
  
  
  OBJECTIVE
  To assess the association between w-3-PUFA intake and fish consumption and mental disorders.
  
  
  METHODS
  A prospective cohort study was performed in 7,903 participants. W-3 PUFA intake and fish consumption were ascertained through a validated semi-quantitative food frequency questionnaire. The outcomes after 2 years of follow-up were: (1) Incident mental disorder (depression, anxiety, or stress), (2) incident depression, and (3) incident anxiety. Logistic regression models and generalized additive models were fit to assess the relationship between w-3 PUFA intake or fish consumption and the incidence of these outcomes. Odds ratios (OR) and their 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  173 cases of depression, 335 cases of anxiety, and 4 cases of stress were observed during 2-year follow-up. ORs (95% CI) of mental disorder for successive quintiles of energy-adjusted w-3 PUFA intake were 1 (reference), 0.72 (0.52-0.99), 0.79 (0.58-1.08), 0.65 (0.47-0.90), and 1.04 (0.78-1.40). Subjects with a moderate consumption of fish (third and fourth quintiles of consumption: median of each quintile 83.3 and 112 g/day, respectively) had a relative risk reduction higher than 30%.
  
  
  CONCLUSIONS
  A potential benefit of w-3 PUFA intake on total mental disorders is suggested, although no linear trend was apparent.
authors: Department of Clinical Sciences, University of Las Palmas de Gran Canaria, P.O. Box 550, 35080 Las Palmas de Gran Canaria, Spain. asanchez@dcc.ulpgc.es
authors: Almudena
authors: A
authors: Sanchez-Villegas
authors: Patricia
authors: P
authors: Henríquez
authors: Adolfo
authors: A
authors: Figueiras
authors: Felipe
authors: F
authors: Ortuño
authors: Francisca
authors: F
authors: Lahortiga
authors: Miguel A
authors: MA
authors: Martínez-González
mesh_terms: D000328:Adult; D001007:Anxiety / Q000453:epidemiology; D015331:Cohort Studies; D016001:Confidence Intervals; D003863:Depression / Q000453:epidemiology; D004032:Diet; D004034:Diet Surveys; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000627:therapeutic use; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D001523:Mental Disorders / Q000178:diet therapy / Q000453:epidemiology*; D016017:Odds Ratio; D011446:Prospective Studies; D012306:Risk; D017747:Seafood / Q000032:analysis; D011795:Surveys and Questionnaires
chemical_list: D015525:Fatty Acids, Omega-3
references: Lancet. 1998 Apr 18;351(9110):1213
references: 9643729
references: Am J Psychiatry. 2004 Mar;161(3):567-9
references: 14992986
references: Biol Psychiatry. 2004 May 1;55(9):891-6
references: 15110732
references: J Affect Disord. 1998 Mar;48(2-3):149-55
references: 9543204
references: Lancet. 1997 May 24;349(9064):1498-504
references: 9167458
references: Int J Epidemiol. 1989 Dec;18(4):858-67
references: 2621022
references: Br J Psychiatry. 2006 Jan;188:46-50
references: 16388069
references: Eur J Clin Invest. 2005 Nov;35(11):691-9
references: 16269019
references: J Agric Food Chem. 2006 Aug 9;54(16):6106-12
references: 16881724
references: Biol Psychiatry. 1998 Mar 1;43(5):315-9
references: 9513745
references: Neurochem Int. 1981 Mar;3(1):37-42
references: 20487806
references: Br J Nutr. 2006 Sep;96(3):523-31
references: 16925858
references: J Affect Disord. 1996 Apr 26;38(1):35-46
references: 8735157
references: J Neurol Neurosurg Psychiatry. 1977 Feb;40(2):168-9
references: 864481
references: Nutr Neurosci. 2002 Feb;5(1):65-73
references: 11929200
references: BMJ. 2004 Jan 3;328(7430):30-5
references: 14703544
references: Prev Med. 2006 Jan;42(1):4-13
references: 16337677
references: Public Health Nutr. 2001 Oct;4(5):981-8
references: 11784411
references: Appetite. 1999 Aug;33(1):141-61
references: 10447986
references: Psychiatr Serv. 2001 Apr;52(4):529-31
references: 11274502
references: Acta Psychiatr Scand. 2006 Jan;113(1):31-5
references: 16390366
references: Appetite. 2000 Dec;35(3):263-8
references: 11073708
references: Lancet. 2006 May 27;367(9524):1747-57
references: 16731270
references: Neuro Endocrinol Lett. 2006 Aug;27(4):415-23
references: 16891999
references: Am J Cardiol. 2002 Dec 15;90(12):1279-83
references: 12480034
references: J Affect Disord. 2004 Nov 1;82(3):447-52
references: 15555697
references: Am J Clin Nutr. 2002 Oct;76(4):750-7
references: 12324287
references: Eur Neuropsychopharmacol. 2006 Feb;16(2):107-13
references: 16243493
references: Epidemiology. 1995 Jul;6(4):450-4
references: 7548361
references: Int J Epidemiol. 1993 Jun;22(3):512-9
references: 8359969
references: Am J Clin Nutr. 2003 Jul;78(1):40-6
references: 12816769
references: Am J Psychiatry. 2006 Jun;163(6):1098-100
references: 16741212
references: Eur J Clin Nutr. 2004 Jan;58(1):24-31
references: 14679363
references: Altern Med Rev. 2003 Nov;8(4):410-25
references: 14653768
references: Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):e20-30
references: 12588785
references: J Affect Disord. 2002 May;69(1-3):15-29
references: 12103448
references: Am J Epidemiol. 2001 Aug 1;154(3):264-75
references: 11479192
references: Prostaglandins Leukot Essent Fatty Acids. 2003 Oct;69(4):237-43
references: 12907133
references: J Neural Transm (Vienna). 1998;105(1):59-68
references: 9588761
references: Lipids. 1999 Feb;34(2):161-9
references: 10102242
references: J Expo Sci Environ Epidemiol. 2007 Jan;17(1):25-30
references: 16912698
references: Psychiatry Res. 1999 Mar 22;85(3):275-91
references: 10333380
references: Am J Epidemiol. 1992 Feb 15;135(4):418-27
references: 1550093
references: Life Sci. 2003 Nov 7;73(25):3181-7
references: 14561523
references: Epidemiology. 1996 Jan;7(1):81-6
references: 8664406
references: Am J Psychiatry. 2002 Sep;159(9):1596-8
references: 12202284
references: Psychiatry Res. 2006 Mar 30;141(3):279-86
references: 16499974
references: Am J Psychiatry. 2002 Mar;159(3):477-9
references: 11870016
references: J Affect Disord. 2004 Feb;78(2):131-40
references: 14706723
references: J Adolesc Health. 2006 May;38(5):569-74
references: 16635769
references: Arch Gen Psychiatry. 2002 Oct;59(10 ):913-9
references: 12365878
references: J Am Diet Assoc. 1993 Jul;93(7):790-6
references: 8320406