Functional networks underlying latent inhibition learning in the mouse brain.
The present study reports the first comprehensive map of brain networks underlying latent inhibition learning and the first application of structural equation modeling to cytochrome oxidase data. In latent inhibition, repeated exposure to a stimulus results in a latent form of learning that inhibits subsequent associations with that stimulus. As neuronal energy demands to form learned associations changes, so does the induction of the respiratory enzyme cytochrome oxidase. Therefore, cytochrome oxidase can be used as an endpoint metabolic marker of the effects of experience on regional brain metabolic capacity. Quantitative cytochrome oxidase histochemistry was used to map brain regions in mice trained on a tone-footshock fear conditioning paradigm with either tone preexposure (latent inhibition), conditioning only (acquisition), conditioning followed by tone alone (extinction), or no handling or conditioning (naive). The ventral cochlear nucleus, medial geniculate, CA1 hippocampus, and perirhinal cortex showed modified metabolic capacity due to latent inhibition. Structural equation modeling was used to determine the causal influences in an anatomical network of these regions and others thought to mediate latent inhibition, including the accumbens and entorhinal cortex. An uncoupling of ascending influences between auditory regions was observed in latent inhibition. There was also a reduced influence on the accumbens from the perirhinal cortex in both latent inhibition and extinction. The results suggest a specific network with a neural mechanism of latent inhibition that appears to involve sensory gating, as evidenced by modifications in metabolic capacity and effective connectivity between auditory regions and reduced perirhinal cortex influence on the accumbens.
Puga
Frank
F
Department of Psychology and Institute for Neuroscience, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712-0187, USA.
Barrett
Douglas W
DW
Bastida
Christel C
CC
Gonzalez-Lima
F
F
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003214:Conditioning, Classical / Q000502:physiology*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005108:Extinction, Psychological / Q000502:physiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*
D003576:Electron Transport Complex IV
Brain Res. 1991 May 3;547(2):295-302
1884204
Neurosci Lett. 1991 Feb 25;123(2):251-3
1709270
J Psychiatr Res. 1992 Oct;26(4):345-66
1491358
Schizophr Bull. 1993;19(2):233-59
8322034
Brain Res. 1993 Nov 5;627(1):129-40
8293293
J Neurophysiol. 1994 Oct;72(4):1717-33
7823097
Neuroscience. 1994 Nov;63(2):559-78
7891865
Brain Res. 1995 Jun 19;683(2):228-41
7552359
J Exp Psychol Anim Behav Process. 1996 Jul;22(3):321-49
8691162
Neurobiol Learn Mem. 1997 Sep;68(2):154-71
9322258
Behav Brain Res. 1997 Oct;88(1):11-25
9401704
Cereb Cortex. 1997 Dec;7(8):768-78
9408041
Eur J Neurosci. 1998 Oct;10(10):3035-43
9786198
Am J Psychiatry. 1998 Dec;155(12):1691-4
9842777
Neurosci Lett. 2005 Jan 10;373(2):94-8
15567560
Neuroreport. 2005 Feb 28;16(3):271-5
15706234
Brain Res Brain Res Rev. 2005 Feb;48(1):1-15
15708625
Behav Brain Res. 2005 Jul 30;162(2):246-55
15970218
Behav Brain Res. 2005 Aug 30;163(1):115-21
15921766
Psychon Bull Rev. 2005 Apr;12(2):224-43
16082802
Behav Brain Res. 2005 Nov 7;164(2):222-30
16095730
Int J Neurosci. 2006 Mar;116(3):265-80
16484053
Neuroscience. 2006 Sep 1;141(3):1163-70
16766126
Neuroscience. 2007 Mar 16;145(2):403-12
17222984
Neuroscience. 2007 Mar 16;145(2):423-37
17257766
J Comp Physiol Psychol. 1959 Aug;52:415-9
14418647
Neurobiol Learn Mem. 1999 Nov;72(3):143-57
10536094
Memory. 1999 Sep-Nov;7(5-6):523-48
10659085
Am J Psychiatry. 2000 May;157(5):767-71
10784470
Brain Behav Evol. 2000 Mar;55(3):139-51
10899708
Behav Neurosci. 2000 Oct;114(5):867-74
11085600
Neural Netw. 2000 Oct-Nov;13(8-9):861-70
11156197
Behav Brain Res. 2001 Jan 29;118(2):123-41
11164510
J Neurophysiol. 2001 Aug;86(2):809-23
11495952
Brain Res Bull. 2001 Sep 1;56(1):49-53
11604248
Biol Psychiatry. 2001 Dec 1;50(11):845-55
11743940
Eur J Neurosci. 2001 Dec;14(11):1915-27
11860486
Behav Neurosci. 2002 Feb;116(1):95-104
11895187
J Neurosci. 2003 Jul 2;23(13):5740-9
12843278
Psychopharmacology (Berl). 2003 Sep;169(3-4):257-97
12601500
Neuroinformatics. 2004;2(2):175-82
15319515
Am J Psychiatry. 2004 Oct;161(10):1822-8
15465979
Cereb Cortex. 2004 Nov;14(11):1256-65
15192010
Neuroimage. 2004;23 Suppl 1:S264-74
15501096
J Comp Neurol. 1980 May 15;191(2):193-212
7410591
Arch Gen Psychiatry. 1984 Jun;41(6):607-12
6732421
J Comp Neurol. 1988 May 8;271(2):208-28
3379162
Trends Neurosci. 1989 Mar;12(3):94-101
2469224
J Comp Neurol. 1989 Sep 15;287(3):339-56
2778109
Psychol Bull. 1990 Nov;108(3):442-61
1980149
J Comp Neurol. 1990 Dec 1;302(1):110-23
1707895
Brain Res. 1992 Apr 24;578(1-2):75-86
1511292