Oral and pharyngeal transit of a paste bolus in Chagas' disease.
We measured the oral and pharyngeal transit of a paste bolus in 20 patients with Chagas' disease and 21 controls. Each subject swallowed of a 10-ml paste bolus prepared with 50 ml of water and 4.5 g of instant food thickener labeled with 55.5 MBq of 99m technetium phytate. After the scintigraphic recording of the transit, we delineated regions of interest (ROI) corresponding to mouth, pharynx, and proximal esophagus. Time-activity curves were generated for each ROI. There was no difference between patients with Chagas' disease and controls with respect to the duration of oral and pharyngeal transit, amount of pharyngeal residue, or flux of bolus entry into the proximal esophagus. The amount of oral residue was higher in patients with Chagas' disease (median = 0.71 ml) than in controls (median = 0.45 ml). The pharyngeal clearance duration was longer in patients with Chagas' disease (median = 0.85 s) than in controls (median = 0.60 s). The oral transit duration of the patients with Chagas' disease and dysphagia (median = 0.55 s, n = 14) was shorter than the oral transit duration of chagasic patients without dysphagia (median = 0.80 s, n = 6). We conclude that when swallowing a paste bolus, patients with Chagas' disease may have an increased amount of oral residue and a longer pharyngeal clearance duration than asymptomatic volunteers.
Gomes
Fernanda Rodrigues
FR
Department of Medicine, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Secaf
Marie
M
Kubo
Tadeu Takao Almodovar
TT
Dantas
Roberto Oliveira
RO
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D014355:Chagas Disease / Q000150:complications / Q000503:physiopathology*; D003679:Deglutition; D003680:Deglutition Disorders / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005471:Fluoroscopy; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009055:Mouth / Q000503:physiopathology*; D010609:Pharyngeal Muscles; D010614:Pharynx / Q000503:physiopathology*; D011877:Radionuclide Imaging; D013997:Time Factors
Adv Parasitol. 1968;6:63-116
4239747
Gastroenterology. 1992 Sep;103(3):823-9
1499933
Braz J Med Biol Res. 2002 Jun;35(6):677-83
12045832
Am J Physiol. 1990 May;258(5 Pt 1):G675-81
2333995
Dysphagia. 2004 Winter;19(1):36-42
14745644
Am J Gastroenterol. 1998 Jun;93(6):884-9
9647012
Dig Dis Sci. 1980 Oct;25(10):790-4
6775917
Dis Esophagus. 2006;19(5):401-5
16984540
Dig Dis Sci. 1983 Apr;28(4):294-9
6403319
Neurogastroenterol Motil. 2000 Aug;12 (4):335-41
10886675
Am J Physiol. 1993 Mar;264(3 Pt 1):G427-32
8460698
J Clin Gastroenterol. 2005 Nov-Dec;39(10):863-8
16208109
Dysphagia. 1989;4(1):8-15
2640180
Dysphagia. 1988;3(2):79-84
3271656
Gastroenterology. 1990 Nov;99(5):1269-74
2210235
Dig Dis Sci. 2001 Jun;46(6):1200-6
11414294
Digestion. 1982;23(1):48-56
6806135
Dysphagia. 2005 Winter;20(1):40-5
15886966
Digestion. 1987;36(4):189-94
3111915
Am J Physiol. 1994 Jun;266(6 Pt 1):G972-7
8023945
Arq Gastroenterol. 1982 Jul-Sep;19(3):127-32
6821025
AJR Am J Roentgenol. 1989 Dec;153(6):1197-9
2816632
Dysphagia. 1996 Winter;11(1):41-7
8556878
Am J Physiol. 1989 Nov;257(5 Pt 1):G748-59
2596608