title: Antioxidative effects of sulfurous mineral water: protection against lipid and protein oxidation.
abstract: OBJECTIVE
  To investigate the antioxidative properties of sulfurous drinking water after a standard hydropinic treatment (500 ml day(-1) for 2 weeks).
  
  
  METHODS
  Forty apparently healthy adults, 18 men and 22 women, age 41-55 years old. The antioxidant profile and the oxidative condition were evaluated in healthy subjects supplemented for 2 weeks with (study group) or without (controls) sulfurous mineral water both before (T0) and after (T1) treatment.
  
  
  RESULTS
  At T1, a significant decrease (P<0.05) in both lipid and protein oxidation products, namely malondialdehyde, carbonyls and AOPP, was found in plasma samples from subjects drinking sulfurous water with respect to controls. Concomitantly, a significant increment (P<0.05) of the total antioxidant capacity of plasma as well as of total plasmatic thiol levels was evidenced. Tocopherols, carotenoids and retinol remained almost unchanged before and after treatment in both groups.
  
  
  CONCLUSIONS
  The improved body redox status in healthy volunteers undergoing a cycle of hydropinic therapy suggests major benefits from sulfurous water consumption in reducing biomolecule oxidation, possibly furnishing valid protection against oxidative damage commonly associated with aging and age-related degenerative diseases.
authors: Istituto di Istologia e Analisi di Laboratorio, Università di Urbino Carlo Bo, Urbino, Italy. s.benedetti@uniurb.it
authors: S
authors: S
authors: Benedetti
authors: F
authors: F
authors: Benvenuti
authors: G
authors: G
authors: Nappi
authors: N A
authors: NA
authors: Fortunati
authors: L
authors: L
authors: Marino
authors: T
authors: T
authors: Aureli
authors: S
authors: S
authors: De Luca
authors: S
authors: S
authors: Pagliarani
authors: F
authors: F
authors: Canestrari
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006862:Hydrogen Sulfide / Q000494:pharmacology* / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008900:Mineral Waters / Q000627:therapeutic use; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D011506:Proteins / Q000378:metabolism*; D014867:Water / Q000737:chemistry
chemical_list: D000975:Antioxidants; D008900:Mineral Waters; D011506:Proteins; D014867:Water; D006862:Hydrogen Sulfide