title: Extensive HLA class I allele promiscuity among viral CTL epitopes.
abstract: Promiscuous binding of T helper epitopes to MHC class II molecules has been well established, but few examples of promiscuous class I-restricted epitopes exist. To address the extent of promiscuity of HLA class I peptides, responses to 242 well-defined viral epitopes were tested in 100 subjects regardless of the individuals' HLA type. Surprisingly, half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Functional assays confirmed the frequent recognition of HLA class I-restricted T cell epitopes on several alternative alleles across HLA class I supertypes and encoded on different class I loci. These data have significant implications for the understanding of MHC class I-restricted antigen presentation and vaccine development.
authors: Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors: Nicole
authors: N
authors: Frahm
authors: Karina
authors: K
authors: Yusim
authors: Todd J
authors: TJ
authors: Suscovich
authors: Sharon
authors: S
authors: Adams
authors: John
authors: J
authors: Sidney
authors: Peter
authors: P
authors: Hraber
authors: Hannah S
authors: HS
authors: Hewitt
authors: Caitlyn H
authors: CH
authors: Linde
authors: Daniel G
authors: DG
authors: Kavanagh
authors: Tonia
authors: T
authors: Woodberry
authors: Leah M
authors: LM
authors: Henry
authors: Kellie
authors: K
authors: Faircloth
authors: Jennifer
authors: J
authors: Listgarten
authors: Carl
authors: C
authors: Kadie
authors: Nebojsa
authors: N
authors: Jojic
authors: Kaori
authors: K
authors: Sango
authors: Nancy V
authors: NV
authors: Brown
authors: Eunice
authors: E
authors: Pae
authors: M Tauheed
authors: MT
authors: Zaman
authors: Florian
authors: F
authors: Bihl
authors: Ashok
authors: A
authors: Khatri
authors: Mina
authors: M
authors: John
authors: Simon
authors: S
authors: Mallal
authors: Francesco M
authors: FM
authors: Marincola
authors: Bruce D
authors: BD
authors: Walker
authors: Alessandro
authors: A
authors: Sette
authors: David
authors: D
authors: Heckerman
authors: Bette T
authors: BT
authors: Korber
authors: Christian
authors: C
authors: Brander
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D006678:HIV / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism*
chemical_list: D018984:Epitopes, T-Lymphocyte; D015395:Histocompatibility Antigens Class I
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