title: Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product--a further simplification of the lactone region.
abstract: Analogues of discodermolide in which the complete C-1 to C-7 fragment is replaced with a coumarin moiety display equivalent potency to that of the natural product.
authors: Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, CA 94545, USA. shaw@kosan.com
authors: Simon J
authors: SJ
authors: Shaw
authors: Hugo G
authors: HG
authors: Menzella
authors: David C
authors: DC
authors: Myles
authors: Ming
authors: M
authors: Xian
authors: Amos B
authors: AB
authors: Smith
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D001688:Biological Products / Q000737:chemistry* / Q000633:toxicity*; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D015394:Molecular Structure; D011753:Pyrones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D000473:Alkanes; D001688:Biological Products; D002219:Carbamates; D003374:Coumarins; D007783:Lactones; D011753:Pyrones; C030123:coumarin; C071229:discodermolide