Severe Henoch-Schönlein purpura in a thalassemic patient under deferiprone treatment.
Herein we present a 7-year-old beta-thalassemia major patient who developed severe Henoch-Schönlein purpura (HSP) with renal, pulmonary involvement and invagination while under iron chelation with deferiprone. DNA analysis for familial Mediterranean fever revealed M696V mutation. Various cellular and humoral immunological impairments have been described in thalassemia major patients and the severe course of HSP in our case may be related to these underlying immunological defects.
Unal
Sule
S
Division of Pediatric Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. suleunal@hacettepe.edu.tr
Gücer
Safak
S
Kale
Gülsev
G
Besbas
Nesrin
N
Ozen
Seza
S
Gümrük
Fatma
F
D019943:Amino Acid Substitution; D002648:Child; D004247:DNA / Q000235:genetics; D000077543:Deferiprone; D010505:Familial Mediterranean Fever / Q000235:genetics; D006801:Humans; D011695:IgA Vasculitis / Q000139:chemically induced*; D007502:Iron Chelating Agents / Q000009:adverse effects*; D008297:Male; D011728:Pyridones / Q000009:adverse effects*; D013156:Splenectomy; D017086:beta-Thalassemia / Q000188:drug therapy*
D007502:Iron Chelating Agents; D011728:Pyridones; D000077543:Deferiprone; D004247:DNA