Synthesis and ring expansions of functionalized spirocyclobutanones.
The first condensations between bis(trimethylsilyloxy)cyclobutene derivatives and functionalized orthoesters are reported. The resulting adducts are readily converted into spirocycloethers, which undergo a variety of -CH2- and -O- insertions with excellent regioselectivity.
Maulide
Nuno
N
Département de Chimie, Université catholique de Louvain, 1 Place Louis Pasteur, 1348 Louvain-la-Neuve, Belgium.
Markó
István E
IE
D000215:Acylation; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D003503:Cyclobutanes; D007783:Lactones; D013141:Spiro Compounds