Amelioration by black tea of sodium fluoride-induced changes in protein content of cerebral hemisphere, cerebellum and medulla oblongata in brain region of mice.
Oral administration of sodium fluoride (NaF, 6 and 12 mg/kg body weight/day) to Swiss strain male albino mice for 30 days caused significant dose-dependant reduction in the content of acidic, basic, neutral, and total protein in cerebral hemisphere, cerebellum and medulla oblongata region of brain. After 30 days of NaF treatment, followed by withdrawal of treatment for 30 days, partial but significant amelioration occurred. Administration of 2% black tea extract alone for 30 days did not cause any significant effect. However, concurrent administration of NaF and black tea extract for 30 days caused significant amelioration in all parameters studied.
Trivedi
Mrugesh H
MH
Department of Zoology, University School of Science, Gujarat University, Ahmedabad 390 009, India.
Verma
Ramtej J
RJ
Chinoy
Niloufer J
NJ
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009419:Nerve Tissue Proteins / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000633:toxicity*; D013662:Tea / Q000737:chemistry*; D013687:Telencephalon / Q000187:drug effects / Q000378:metabolism
D000975:Antioxidants; D009419:Nerve Tissue Proteins; D010936:Plant Extracts; D013662:Tea; D012969:Sodium Fluoride