-463 G/A myeloperoxidase promoter polymorphism in giant cell arteritis.
OBJECTIVE
To investigate potential associations between-463 G/A myeloperoxidase (MPO) promoter polymorphism and susceptibility to, and clinical features of giant cell arteritis (GCA).


METHODS
A total of 156 patients with biopsy-proven GCA who were residents of Reggio Emilia, Italy, and 235 population-based controls from the same geographic area were genotyped for-463 G/A promoter polymorphism of the MPO gene by molecular methods. The patients were subgrouped according to the presence or absence of polymyalgia rheumatica and severe ischaemic complications (visual loss and/or cerebrovascular accidents).


RESULTS
The distribution of the MPO-G/A genotype differed significantly between patients with GCA and the controls (p(corr) = 0.003). Allele G was significantly more frequent in patients with GCA than in the controls (p(corr) = 0.0002, OR 2.0, 95% CI 1.4 to 2.9). Homozygosity for the G allele was significantly more frequent in patients with GCA than in controls (p(corr) = 0.0002, OR 2.2, 95% CI 1.4 to 3.4). No significant associations were found when patients with GCA with and without polymyalgia rheumatica or with and without severe ischaemic complications were compared.


CONCLUSIONS
Our findings show that the-463 G/A promoter polymorphism of the MPO gene is associated with GCA susceptibility and support a role for MPO in the pathophysiology of GCA.
Salvarani
C
C
Unitè Operativa di Reumatologia, Arcispedale S. Maria Nuova, Viale Risorgimento n 80, Reggio Emilia, 42100, Italy. salvarani.carlo@asmn.re.it
Casali
B
B
Farnetti
E
E
Pipitone
N
N
Nicoli
D
D
Macchioni
P L
PL
Cimino
L
L
Bajocchi
G L
GL
Catanoso
M G
MG
Pattacini
L
L
Ghinoi
A
A
Restuccia
G
G
Boiardi
L
L
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D013700:Giant Cell Arteritis / Q000150:complications / Q000235:genetics*; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D011111:Polymyalgia Rheumatica / Q000150:complications / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D012042:Registries
D009195:Peroxidase