title: Prognostic significance of platelet-derived growth factor-BB expression in human esophageal squamous cell carcinomas.
abstract: BACKGROUND
  Cancer metastases are commonly found in the lymphatic system and tumor lymphangiogenesis requires the interplay of several growth factors. The expression of platelet-derived growth factor (PDGF)-BB and vascular endothelial growth factor (VEGF)-C in esophageal cancer was investigated to define their clinicopathological significance.
  
  
  METHODS
  Using immunohistochemistry, the expression of PDGF-BB and VEGF-C was examined, along with lymphatic vessel density (LVD) in 53 patients with esophageal cancer.
  
  
  RESULTS
  PDGF-BB and VEGF-C expression was positive in 31 cases (58.5%) and 38 cases (71.7%), respectively, and expression correlated with lymph node metastasis and lymphatic invasion. Furthermore, PDGF-BB expression correlated with the depth of tumor invasion and the size of the tumor, and PDGF-BB-positive patients had a significantly poorer prognosis than PDGF-BB-negative patients. The LVD in positive PDGF-BB or VEGF-C tumors was higher than in negative tumors.
  
  
  CONCLUSIONS
  PDGF-BB may play a pivotal role in lymphangiogenesis and tumor growth in esophageal cancer.
authors: Department of Surgery, Nara Medical University School of Medicine, Nara, Japan. msohei@naramed-u.ac.jp
authors: Sohei
authors: S
authors: Matsumoto
authors: Yukishige
authors: Y
authors: Yamada
authors: Michihiro
authors: M
authors: Narikiyo
authors: Masato
authors: M
authors: Ueno
authors: Hidetoshi
authors: H
authors: Tamaki
authors: Katsuhiko
authors: K
authors: Miki
authors: Kohei
authors: K
authors: Wakatsuki
authors: Koji
authors: K
authors: Enomoto
authors: Tomoyo
authors: T
authors: Yokotani
authors: Yoshiyuki
authors: Y
authors: Nakajima
mesh_terms: D000368:Aged; D000077214:Becaplermin; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis*; D011379:Prognosis; D020574:Proto-Oncogene Proteins c-sis; D042582:Vascular Endothelial Growth Factor C / Q000096:biosynthesis
chemical_list: D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D042582:Vascular Endothelial Growth Factor C; D000077214:Becaplermin