title: Chronic eczematous eruptions of the elderly are associated with chronic exposure to calcium channel blockers: results from a case-control study.
abstract: It has been suggested that chronic eczematous eruptions of the elderly could be associated with chronic drug exposure. To determine the drugs associated with these eruptions, we conducted a case-control study on 102 cases and 204 controls. Cases were consecutive patients older than 60 years presenting with an eczematous eruption that had evolved continuously or recurrently for more than 3 months without a reliable cause. Two controls were matched to each case on age, sex, in/outpatient origin, and center. Information about drug exposure was obtained from patients and their pharmacists. Drug use for more than 3 months within the year preceding the eruption was compared between cases and controls. An association was found between calcium channel blockers (CCB) and eczema, with a matched OR (odds ratio) of 2.5 (95% CI (confidence interval): 1.3-4.6). To ascertain the course of patients after CCB withdrawal, two ancillary studies were performed on 74 patients with eczematous eruptions from our department before the case-control study period, and on 101 patients registered in the French "Pharmacovigilance" database. Healing of these eruptions after CCB withdrawal occurred in 83 and 68% of these cases, respectively. The long-term use of CCB is a risk factor for chronic eczematous eruptions of the elderly.
authors: Department of Dermatology, Inserm U519, Rouen University Hospital, Rouen, France. Pascal.Joly@chu-rouen.fr
authors: Pascal
authors: P
authors: Joly
authors: Cloe
authors: C
authors: Benoit-Corven
authors: Sophie
authors: S
authors: Baricault
authors: Audrey
authors: A
authors: Lambert
authors: Marie F
authors: MF
authors: Hellot
authors: Véronique
authors: V
authors: Josset
authors: Annick
authors: A
authors: Barbaud
authors: Philippe
authors: P
authors: Courville
authors: Emmanuel
authors: E
authors: Delaporte
authors: Evelyne
authors: E
authors: Collet
authors: Priscille
authors: P
authors: Carvalho
authors: Anne B
authors: AB
authors: Modeste-Duval
authors: Jean P
authors: JP
authors: Lacour
authors: Marie H
authors: MH
authors: L'Anthoën-Arditi
authors: Christian
authors: C
authors: Thuillez
authors: Jacques
authors: J
authors: Benichou
mesh_terms: D000368:Aged; D001706:Biopsy; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D012867:Skin / Q000473:pathology; D017443:Skin Diseases, Eczematous / Q000175:diagnosis* / Q000209:etiology*; D013997:Time Factors
chemical_list: D002121:Calcium Channel Blockers