title: Cost-effectiveness of various diagnostic approaches for occupational asthma.
abstract: BACKGROUND
  Diagnosis of occupational asthma (OA) by specific inhalation challenge (SIC) can be costly and is not always available. The use of sputum testing to avoid this in some patients may be a more cost-effective alternative.
  
  
  OBJECTIVE
  To compare the cost-effectiveness of SIC with serial measurements of sputum cell counts (sputum testing) and peak expiratory flow (PEF) monitoring.
  
  
  METHODS
  Clinical data and testing costs for OA in 49 patients were collected during a previously published trial, modelled and compared using TreeAge Pro. Clinical outcome was the percentage of accurately diagnosed patients, using SIC as the gold standard. The PEF approach used the most accurate assessment of five experts who were blinded to SIC results. Differences in the proportion of eosinophils during periods on and off work were used for the sputum testing approach and in PEF/sputum for the combined approach. Unit costs were estimated from charges in Canadian hospitals. Data were analyzed by one-way and two-way analyses, and by probabilistic sensitivity analysis using a Monte Carlo simulation technique.
  
  
  RESULTS
  The PEF approach had an estimated accuracy of 52% and cost $365 per patient tested. Compared with PEF monitoring, sputum testing was more accurate and cost an estimated $255 for each additional OA patient correctly diagnosed. SIC costs per additional correct diagnosis were $11,032 compared with sputum testing and $6,458 compared with PEF monitoring. The combined PEF/sputum testing approach was not cost-effective in the base case analysis, but cannot be excluded according to probabilistic sensitivity analyses.
  
  
  CONCLUSIONS
  Although SIC remains the reference test to diagnose OA, when this test is not available, sputum testing is a cost-effective alternative to PEF for diagnosis of OA.
authors: Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada.
authors: Wendy A
authors: WA
authors: Kennedy
authors: Frédéric
authors: F
authors: Girard
authors: Simone
authors: S
authors: Chaboillez
authors: André
authors: A
authors: Cartier
authors: Johanne
authors: J
authors: Côté
authors: Frederick
authors: F
authors: Hargreave
authors: Manon
authors: M
authors: Labrecque
authors: Jean-Luc
authors: JL
authors: Malo
authors: Susan M
authors: SM
authors: Tarlo
authors: Carrie A
authors: CA
authors: Redlich
authors: Catherine
authors: C
authors: Lemière
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000175:diagnosis* / Q000191:economics*; D001992:Bronchoalveolar Lavage Fluid; D002170:Canada; D003362:Cost-Benefit Analysis; D004804:Eosinophils / Q000166:cytology; D017048:Health Care Costs; D006801:Humans; D008499:Medical Records; D009010:Monte Carlo Method; D009784:Occupational Diseases / Q000175:diagnosis* / Q000191:economics*; D010366:Peak Expiratory Flow Rate; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013183:Sputum / Q000166:cytology*; D017132:Workplace
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