title: A new cytotoxic cholesterol sulfate from marine sponge Halichondria rugosa.
abstract: A new steroid, 24xi,25-dimethyl-3alpha-hydroxyl-cholest-5-ene-2beta-ol sodium sulfate (1), together with a known steroid, 24xi,25-dimethyl-cholest-5-ene-2beta,3alpha-diol disodium sulfate (2), was isolated from the ethanol extract of marine sponge Halichondria rugosa. Their structures were elucidated on the base of spectroscopic analysis. Both compounds showed cytotoxicity to four human cancer cell lines (BEL-7402, HT-29, SPC-A1 and U-251) with IC(50) values between 6.5 and 23.1 microM.
authors: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200433, China.
authors: Hong-Jun
authors: HJ
authors: Zhang
authors: Jing-Bo
authors: JB
authors: Sun
authors: Hou-Wen
authors: HW
authors: Lin
authors: Zeng-Lei
authors: ZL
authors: Wang
authors: Hua
authors: H
authors: Tang
authors: Ping
authors: P
authors: Cheng
authors: Wan-Sheng
authors: WS
authors: Chen
authors: Yang-Hua
authors: YH
authors: Yi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002788:Cholesterol Esters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera
chemical_list: C523932:24xi,25-dimethyl-3alpha-hydroxyl-cholest-5-ene-2beta-ol; D000970:Antineoplastic Agents; D002788:Cholesterol Esters; C007045:cholesteryl sulfate