Quality of the Haemophilus influenzae type b (Hib) antibody response induced by diphtheria-tetanus-acellular pertussis/Hib combination vaccines.
It has been repeatedly observed that mixing Haemophilus influenzae type b (Hib) conjugate vaccines with acellular pertussis-containing vaccines (diphtheria-tetanus-acellular pertussis [DTPa]) resulted in a reduced magnitude of the anti-polyriboseribitolphosphate antibody response compared to that obtained when Hib vaccines were administered separately and not mixed. Nevertheless, the quality and functionality of the immune responses have been shown to be the same. With the purpose of investigating the quality of the anti-Hib immune responses that are elicited under different vaccination regimens, we report here four primary and booster-based pediatric clinical trials in which Hib vaccine was either mixed with DTPa or diphtheria-tetanus-whole-cell pertussis (DTPw)-based vaccines or was coadministered. Our results show that avidity maturation of the antibodies was lower when primary vaccination involved DTPa mixed with Hib compared to when DTPa and Hib were coadministered. No such difference was observed between mixed and separately administered Hib when associated with DTPa-hepatitis B virus-inactivated poliovirus or DTPw-based vaccines. All different combinations and regimens elicited the same opsonophagocytic and bactericidal activity as well as the same ability to protect in a passive infant rat protection assay. The functional activity of mixed DTPa-based and Hib vaccines was similar to that of mixed DTPw-based/Hib combinations. In conclusion, in vitro and in vivo data as well as postmarketing vaccine effectiveness data attest to the ability of DTPa-based/Hib combination vaccines to effectively prevent Hib-induced disease in children.
Denoël
Philippe A
PA
GlaxoSmithKline Biologicals, Rue de l'Institut 89, 1330 Rixensart, Belgium.
Goldblatt
David
D
de Vleeschauwer
Isabel
I
Jacquet
Jeanne-Marie
JM
Pichichero
Michael E
ME
Poolman
Jan T
JT
D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000097:blood; D000915:Antibody Affinity; D001770:Blood Bactericidal Activity / Q000276:immunology; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000276:immunology*; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D019741:Haemophilus influenzae type b / Q000276:immunology*; D006801:Humans; D007116:Immunization, Passive; D007117:Immunization, Secondary; D007223:Infant; D051381:Rats; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology
D000907:Antibodies, Bacterial; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D018073:Haemophilus Vaccines; D017778:Vaccines, Combined
Vaccine. 2000 Nov 22;19(7-8):825-33
11115705
Pediatr Infect Dis J. 2000 Jul;19(7):589-91
10917213
Pediatr Infect Dis J. 2001 Aug;20(8):767-74
11734739
Lancet. 2003 Feb 1;361(9355):360-1
12573368
Lancet. 2003 May 3;361(9368):1521-3
12737866
J Infect Dis. 2003 Aug 15;188(4):481-5
12898433
Lancet. 2004 Jul 24-30;364(9431):365-7
15276396
J Infect Dis. 1983 Jun;147(6):1100
6602191
J Infect Dis. 1984 Jun;149(6):1034-5
6610714
J Infect Dis. 1986 Dec;154(6):935-43
3491165
J Immunol. 1987 Sep 15;139(6):1999-2004
3497985
J Infect Dis. 1988 Jan;157(1):85-90
3257245
N Engl J Med. 1990 Nov 15;323(20):1381-7
2233904
JAMA. 1992 Mar 18;267(11):1489-94
1538539
J Immunol. 1995 Apr 15;154(8):4195-202
7706754
Biologicals. 1994 Dec;22(4):397-402
7779368
Eur J Pediatr. 1997 Jan;156(1):18-24
9007484
Eur J Pediatr. 1997 Apr;156(4):282-7
9128812
J Infect Dis. 1998 Apr;177(4):1112-5
9534995
Eur J Pediatr. 1998 Mar;157(3):208-14
9537487
Vaccine. 1998 May-Jun;16(9-10):921-7
9682338
J Infect Dis. 1999 Aug;180(2):538-41
10395878
J Infect Dis. 1999 Oct;180(4):1390-3
10479180
Pediatr Infect Dis J. 2004 Oct;23(10):944-50
15602195
Vaccine. 2005 Jul 14;23(32):4097-100
15908059
Lancet. 2005 Jul 9-15;366(9480):144-50
16005337
Pediatr Infect Dis J. 2006 Apr;25(4):312-9
16567982
Emerg Infect Dis. 2006 Jun;12(6):937-41
16707049
Pediatr Infect Dis J. 2006 Aug;25(8):706-12
16874170
JAMA. 2000 Nov 8;284(18):2334-40
11066183
Lancet. 1999 Dec 11;354(9195):2063-8
10636384
Clin Microbiol Rev. 2000 Apr;13(2):302-17
10756001
Vaccine. 2001 Mar 21;19(17-19):2280-5
11257348