Cholecystectomy and the risk of colorectal adenomas.
Cholecystectomy has been identified as a risk factor for colorectal cancer, yet little attention has been given to the relationship between cholecystectomy and colorectal adenomas. Utilizing data collected in two large cross-sectional studies of colorectal adenoma risk factors, we examined the association between cholecystectomy and colorectal adenomas. In the adjusted logistic regression model, both men and women showed no effect of cholecystectomy on risk of colorectal adenomas (men: OR 0.67 [95% CI 0.30-1.47]; women: OR 1.46 [95% CI 0.92-2.29]). No effect was seen when examining the time since cholecystectomy for men. There was a slight association found for women who had a cholecystectomy less than 10 years prior (OR 2.02 [95% CI 1.06-3.87]) but no association was seen in women with cholecystectomy at least 10 years prior (OR 1.14 [95% CI 0.62-2.09]). Thus, we conclude that, although cholecystectomy is a risk factor for colorectal cancer, cholecystectomy is not a risk factor for colorectal adenomas.
Vinikoor
Lisa C
LC
Department of Epidemiology, School of Public Health, University of North Carolina, CB#7555, Chapel Hill, NC 27599-7555, USA. vinikoor@email.unc.edu
Galanko
Joseph A
JA
Sandler
Robert S
RS
D000236:Adenoma / Q000209:etiology* / Q000473:pathology; D000328:Adult; D000368:Aged; D002763:Cholecystectomy / Q000009:adverse effects*; D003106:Colon / Q000473:pathology; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
Am J Surg. 2001 Jun;181(6):526-8
11513778
Am J Gastroenterol. 2005 Aug;100(8):1813-20
16086719
Am J Epidemiol. 2001 Dec 15;154(12):1089-99
11744511
Br J Cancer. 2003 Jan 13;88(1):79-83
12556963
JAMA. 2003 Dec 10;290(22):2959-67
14665657
Rom J Gastroenterol. 2004 Sep;13(3):187-93
15470530
Gut. 1984 Aug;25(8):863-6
6745725
Am J Epidemiol. 1986 Sep;124(3):453-69
3740045
Gut. 1986 Oct;27(10):1181-5
3781331
Cancer. 1988 Feb 1;61(3):618-21
3338028
Dig Dis Sci. 1988 Sep;33(9):1178-84
3409804
Ann R Coll Surg Engl. 1989 Jan;71(1):37-9
2923417
Epidemiology. 1990 Jan;1(1):58-64
2081241
Cancer. 1991 Oct 1;68(7):1644-7
1893365
Gastroenterology. 1993 Jul;105(1):130-41
8514030
Scand J Gastroenterol. 1996 Feb;31(2):160-9
8658039
Am J Gastroenterol. 1999 Jan;94(1):41-6
9934729
Am J Epidemiol. 1999 Sep 15;150(6):547-51
10489992
Gastroenterology. 2001 Sep;121(3):542-7
11522737