title: A high-saturated fat diet enriched with phytosterol and pectin affects the fatty acid profile in guinea pigs.
abstract: This paper presents the results of a study whose aim was to test the effects of several doses of pectin and phytosterols on the body weight gain and the FA content in female guinea pigs. The treatments resulted from supplementing with pectin and plant sterol a guinea pig diet (rich in saturated FA), following a 3 x 3 factorial design, with three levels of pectin (0, 3.67 and 6.93%) and three levels of phytosterols (0, 1.37, and 2.45%). Seventy-two female Dunkin Hartley guinea pigs were randomly assigned to the treatment groups (8 animals/group), the duration of the treatment being 4 wk. Pectin dietary intake led to a significant increase in body weight (P < 0.001), food consumption (P = 0.025), and feed efficiency (P < 0.001), but no influence of phytosterols on weight gain or food consumption was detected. We found a significant negative effect of the addition of phytosterols on lauric, myristic, and palmitic acid contents in feces, and a positive effect on their concentration in plasma and liver, but no significant effect on stearic acid content. Apparent FA absorption was assessed by calculating the ratio of FA in feces and diets that the absorption of the different FA could be compared, and the negative effect of phytosterol supplementation on these ratios, especially for lauric and myristic acids, was established.
authors: Department of Nutrition and Food Science-Centre de Referència en Tecnologia d'Aliments (CeRTA), University of Barcelona, 08028 Barcelona, Spain.
authors: Gemma
authors: G
authors: Brufau
authors: Miguel Angel
authors: MA
authors: Canela
authors: Magda
authors: M
authors: Rafecas
mesh_terms: D000818:Animals; D001835:Body Weight; D002849:Chromatography, Gas; D004041:Dietary Fats / Q000008:administration & dosage*; D004435:Eating; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D005243:Feces / Q000737:chemistry; D005260:Female; D006168:Guinea Pigs; D008099:Liver / Q000737:chemistry; D010368:Pectins / Q000494:pharmacology*; D010840:Phytosterols / Q000494:pharmacology*
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D010840:Phytosterols; D010368:Pectins
references: J Nutr. 1993 Apr;123(4):649-55
references: 8385211
references: J Am Coll Nutr. 2002 Dec;21(6):495-505
references: 12480795
references: Ann Med. 2004;36(2):126-34
references: 15119832
references: J Am Coll Cardiol. 2000 Apr;35(5):1185-91
references: 10758959
references: J Am Coll Nutr. 2001 Feb;20(1):5-19
references: 11293467
references: N Engl J Med. 1990 Jan 18;322(3):147-52
references: 2152973
references: J Lipid Res. 1983 Sep;24(9):1196-209
references: 6605404
references: J Nutr. 1998 Sep;128(9):1434-41
references: 9732302
references: Curr Opin Lipidol. 2000 Dec;11(6):571-6
references: 11086329
references: N Engl J Med. 1995 Nov 16;333(20):1308-12
references: 7566021
references: J Nutr. 1992 Feb;122(2):246-53
references: 1310108
references: Am J Clin Nutr. 2003 Dec;78(6):1085-91
references: 14668268
references: Eur J Clin Invest. 1993 Dec;23(12):827-31
references: 8143759
references: Metabolism. 1991 Aug;40(8):842-8
references: 1650421
references: J Lipid Res. 1995 Nov;36(11):2394-404
references: 8656077
references: Prev Med. 1987 Jul;16(4):525-31
references: 3628202
references: J Agric Food Chem. 1981 May-Jun;29(3):455-61
references: 6265518
references: Arterioscler Thromb Vasc Biol. 1997 Jan;17(1):119-26
references: 9012646
references: Nutr Rev. 2000 Jun;58(6):188-91
references: 10885328
references: Atherosclerosis. 2002 Jan;160(1):205-13
references: 11755939
references: Nutr Metab Cardiovasc Dis. 2006 Jan;16(1):13-21
references: 16399487
references: Circulation. 2000 Oct 31;102(18):2284-99
references: 11056107
references: Eur J Clin Nutr. 2004 Mar;58(3):503-9
references: 14985690
references: Am J Clin Nutr. 1995 May;61(5):1120-8
references: 7733038
references: Biochem Cell Biol. 1986 Aug;64(8):847-53
references: 3768170
references: Am J Clin Nutr. 1992 Nov;56(5):895-8
references: 1415008
references: Eur J Clin Nutr. 1999 Apr;53(4):319-27
references: 10334658
references: J Nutr. 1987 Apr;117(4):660-5
references: 3585514
references: Biochim Biophys Acta. 1983 Aug 10;732(3):651-8
references: 6615593
references: N Engl J Med. 1988 May 12;318(19):1244-8
references: 3362176
references: Atherosclerosis. 2003 Jul;169(1):41-50
references: 12860249
references: J Nutr. 2003 Oct;133(10):3103-9
references: 14519792
references: Anal Biochem. 2000 Jul 1;282(2):250-5
references: 10873281
references: Mayo Clin Proc. 2003 Aug;78(8):965-78
references: 12911045
references: Circulation. 2002 Nov 19;106(21):2747-57
references: 12438303
references: Atherosclerosis. 1998 May;138(1):101-10
references: 9678775
references: Eur J Clin Nutr. 2000 Sep;54(9):715-25
references: 11002384
references: Digestion. 2003;67(1-2):42-9
references: 12743440
references: Ann Nutr Metab. 1994;38(4):203-11
references: 7832580
references: J Clin Invest. 1970 May;49(5):952-67
references: 5441548
references: J Nutr. 1994 Jan;124(1):78-83
references: 8283297
references: Metabolism. 2005 Jan;54(1):38-48
references: 15562378
references: Br J Nutr. 1999 Jan;81(1):37-43
references: 10341674
references: BMJ. 1996 Jul 13;313(7049):84-90
references: 8688759
references: Atherosclerosis. 1999 Apr;143(2):341-51
references: 10217363
references: Atherosclerosis. 2001 Aug;157(2):375-81
references: 11472737
references: Br J Nutr. 1985 May;53(3):409-25
references: 4063281
references: J Nutr. 2000 Mar;130(3):600-7
references: 10702591
references: Am J Clin Nutr. 1996 Jun;63(6):897-903
references: 8644684
references: J Biol Chem. 1957 May;226(1):497-509
references: 13428781
references: Curr Opin Lipidol. 1995 Dec;6(6):365-8
references: 8750249
references: J Nutr. 1993 Feb;123(2):244-52
references: 8381479
references: Metabolism. 2002 Dec;51(12):1519-21
references: 12489060
references: Atherosclerosis. 1998 Oct;140(2):199-270
references: 9862269
references: Curr Opin Lipidol. 1998 Dec;9(6):527-31
references: 9868587
references: Am J Clin Nutr. 1994 Dec;60(6 Suppl):1023S-1028S
references: 7977144
references: Eur J Clin Nutr. 2001 Dec;55(12):1084-90
references: 11781675
references: J Lipid Res. 1998 Jul;39(7):1455-65
references: 9684749
references: J Nutr. 2002 Jul;132(7):1983-8
references: 12097680
references: J Nutr. 2003 Dec;133(12):4129-34
references: 14652360
references: Circulation. 1999 Apr 6;99(13):1733-9
references: 10190884
references: Atherosclerosis. 1976 Jul-Aug;24(1-2):301-9
references: 942524