title: Locally advanced intrahepatic cholangiocarcinoma successfully resected after transcatheter arterial chemoembolization with degradable starch microspheres: report of a case.
abstract: We describe a case of initially unresectable locally advanced intrahepatic cholangiocarcinoma that showed remarkable regression after transcatheter arterial chemoembolization with degradable starch microspheres, allowing for subsequent successful curative resection. A 75-year-old female was referred to our hospital with a large hepatic mass. Computerized tomography examination showed a huge mass in the right liver extended partially to the left liver. Intrahepatic cholangiocarcinoma was strongly suspected, but surgical resection was abandoned due to the local spread in the liver. Three courses of transcatheter arterial chemoembolization with degradable starch microspheres were performed. The anticancer agents, mitomycin C and epirubicin, combined with degradable starch microspheres were injected from the catheter for chemoembolization. After three courses of transcatheter arterial chemoembolization, the tumor size decreased from 10cm to 5.5cm in diameter. Then right trisegmentectomy together with extra-hepatic bile duct excision was performed. At 25 months after the first therapy and 21 months after operation, the patient remains healthy without recurrence. Transcatheter arterial chemotherapy with degradable starch microspheres may be a treatment of choice with locally advanced intrahepatic cholangiocarcinoma.
authors: Department of Gastrointestinal Surgery, Cancer Institute Hospital, Japan.
authors: Yongyou
authors: Y
authors: Wu
authors: Akio
authors: A
authors: Saiura
authors: Junji
authors: J
authors: Yamamoto
authors: Rintaro
authors: R
authors: Koga
authors: Shingo
authors: S
authors: Asahara
authors: Akira
authors: A
authors: Kamei
authors: Koichi
authors: K
authors: Takano
authors: Takaaki
authors: T
authors: Ikari
authors: Makoto
authors: M
authors: Seki
authors: Toshiharu
authors: T
authors: Yamaguchi
authors: Tetsuichiro
authors: T
authors: Muto
mesh_terms: D000368:Aged; D001158:Arteries; D001650:Bile Duct Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D001653:Bile Ducts, Intrahepatic; D002404:Catheterization; D016461:Chemoembolization, Therapeutic / Q000379:methods; D018281:Cholangiocarcinoma / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D006801:Humans; D008863:Microspheres; D012074:Remission Induction; D013213:Starch / Q000008:administration & dosage*
chemical_list: C083286:degradable starch microspheres; D013213:Starch