title: Effects of glucocorticoids on age-related impairments of hippocampal structure and function in mice.
abstract: Effects of glucocorticoids (GCs) on maze-learning performances and hippocampal morphology were observed in male C57BL/6Cr mice. Correlations between aging, GCs and maze-learning performances were also studied. (2) Eight-arm radial maze was used in maze-learning tests. Learning performance was assessed by the parameters of time of getting all the bait, number of reentry errors into the already-entered arm with bait, and number of missed entries into an unbaited arm. Brain sections, 8 mum thick, were Nissl-stained with cresyl violet or stained immunocytochemically with antibodies against neurofilaments. (3) With aging, normal pyramidal cells decreased gradually in amount, and degenerating cells increased since the age of 18 months, accompanied with the maze-learning deficit. Here we have suggested that these changes were associated with the age-related deficits in adaptation tolerance of neurons to stress. In addition, the age-related deficits in plasticity of hippocampal neurons to GCs in young mice (3 months of age) resulted in an increase in plasma corticosterone (CORT) concentrations, degeneration of hippocampal pyramidal cells, as well as maze-learning deficits. (4) In conclusion, our data indicated that CORT caused the degeneration of hippocampal pyramidal cells and the impairment of memory.
authors: Department of Pharmacology, Institute of Materia Medica, Key Laboratory of Bioactive Substances and Resources Utilization, Ministry of Education, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
authors: Wen-Bin
authors: WB
authors: He
authors: Jun-Long
authors: JL
authors: Zhang
authors: Jin-Feng
authors: JF
authors: Hu
authors: Yun
authors: Y
authors: Zhang
authors: Takeo
authors: T
authors: Machida
authors: Nai-Hong
authors: NH
authors: Chen
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000097:blood / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology; D005938:Glucocorticoids / Q000097:blood / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL; D017966:Pyramidal Cells / Q000187:drug effects / Q000473:pathology / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D003345:Corticosterone
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