title: Cytotoxic ent-abietane diterpenes from Gelonium aequoreum.
abstract: Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.
authors: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors: Chia-Lin
authors: CL
authors: Lee
authors: Fang-Rong
authors: FR
authors: Chang
authors: Pei-Wen
authors: PW
authors: Hsieh
authors: Michael-Y
authors: MY
authors: Chiang
authors: Chin-Chung
authors: CC
authors: Wu
authors: Zih-You
authors: ZY
authors: Huang
authors: Yu-Hsuan
authors: YH
authors: Lan
authors: Mei
authors: M
authors: Chen
authors: Kuo-Hsiung
authors: KH
authors: Lee
authors: Hsin-Fu
authors: HF
authors: Yen
authors: Wen-Chun
authors: WC
authors: Hung
authors: Yang-Chang
authors: YC
authors: Wu
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
chemical_list: D045784:Abietanes