Effects of an intensive rehabilitation programme on patients with Huntington's disease: a pilot study.
OBJECTIVE
To investigate the effects of an intensive, inpatient rehabilitation programme on individuals affected by Huntington's disease.


METHODS
A pilot study. Within-subjects design.


METHODS
Inpatient rehabilitation home of the Italian welfare system.


METHODS
Forty patients, early and middle stage of the disease, were recruited to an intensive, inpatient rehabilitation protocol.


METHODS
The treatment programme included respiratory exercises and speech therapy, physical and occupational therapy and cognitive rehabilitation exercises. The programme involved three-week admission periods of intensive treatment that could be repeated three times a year.


METHODS
A standard clinical assessment was performed at the beginning of each admission using the Zung Depression Scale, Mini-Mental State Examination (MMSE), Barthel Index, Tinetti Scale and Physical Performance Test (PPT). Tinetti and PPT were also used at the end of each admission to assess the outcomes in terms of motor and functional performance.


RESULTS
Each three-week period of treatment resulted in highly significant (P < 0.001) improvements of motor performance and daily life activities. The average increase was 4.7 for Tinetti and 5.21 for PPT scores. No carry-over effect from one admission to the next was apparent but at the same time, no motor decline was detected over two years, indicating that patients maintained a constant level of functional, cognitive as well as motor performance.


CONCLUSIONS
Intensive rehabilitation treatments may positively influence the maintenance of functional and motor performance in patients with Huntington's disease.
Zinzi
Paola
P
ISTC, National Research Council, Rome. paola.zinzi@istc.cnr.it
Salmaso
Dario
D
De Grandis
Rosa
R
Graziani
Graziano
G
Maceroni
Stefano
S
Bentivoglio
Annarita
A
Zappata
Paolo
P
Frontali
Marina
M
Jacopini
Gioia
G
D000203:Activities of Daily Living; D001945:Breathing Exercises; D003071:Cognition; D003863:Depression / Q000628:therapy; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000523:psychology / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D009788:Occupational Therapy; D010045:Outpatients; D026741:Physical Therapy Modalities; D010865:Pilot Projects; D013070:Speech Therapy; D016896:Treatment Outcome