title: Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts.
abstract: BACKGROUND
  DLG5 p.R30Q has been reported to be associated with Crohn disease (CD), but this association has not been replicated in most studies. A recent analysis of gender-stratified data from two case-control studies and two population cohorts found an association of DLG5 30Q with increased risk of CD in men but not in women and found differences between 30Q population frequencies for males and females. Male-female differences in population allele frequencies and male-specific risk could explain the difficulty in replicating the association with CD.
  
  
  METHODS
  DLG5 R30Q genotype data were collected for patients with CD and controls from 11 studies that did not include gender-stratified allele counts in their published reports and tested for male-female frequency differences in controls and for case-control frequency differences in men and in women.
  
  
  RESULTS
  The data showed no male-female allele frequency differences in controls. An exact conditional test gave marginal evidence that 30Q is associated with decreased risk of CD in women (p = 0.049, OR = 0.87, 95% CI 0.77 to 1.00). There was also a trend towards reduced 30Q frequencies in male patients with CD compared with male controls, but this was not significant at the 0.05 level (p = 0.058, OR = 0.87, 95% CI 0.74 to 1.01). When data from this study were combined with previously published, gender-stratified data, the 30Q allele was found to be associated with decreased risk of CD in women (p = 0.010, OR = 0.86, 95% CI 0.76 to 0.97), but not in men.
  
  
  CONCLUSIONS
  DLG5 30Q is associated with a small reduction in risk of CD in women.
authors: B L
authors: BL
authors: Browning
authors: V
authors: V
authors: Annese
authors: M L
authors: ML
authors: Barclay
authors: S A
authors: SA
authors: Bingham
authors: S
authors: S
authors: Brand
authors: C
authors: C
authors: Büning
authors: M
authors: M
authors: Castro
authors: S
authors: S
authors: Cucchiara
authors: B
authors: B
authors: Dallapiccola
authors: H
authors: H
authors: Drummond
authors: L R
authors: LR
authors: Ferguson
authors: A
authors: A
authors: Ferraris
authors: S A
authors: SA
authors: Fisher
authors: R B
authors: RB
authors: Gearry
authors: J
authors: J
authors: Glas
authors: L
authors: L
authors: Henckaerts
authors: C
authors: C
authors: Huebner
authors: D
authors: D
authors: Knafelz
authors: L
authors: L
authors: Lakatos
authors: P L
authors: PL
authors: Lakatos
authors: A
authors: A
authors: Latiano
authors: X
authors: X
authors: Liu
authors: C
authors: C
authors: Mathew
authors: B
authors: B
authors: Müller-Myhsok
authors: W G
authors: WG
authors: Newman
authors: E R
authors: ER
authors: Nimmo
authors: C L
authors: CL
authors: Noble
authors: O
authors: O
authors: Palmieri
authors: M
authors: M
authors: Parkes
authors: I
authors: I
authors: Petermann
authors: P
authors: P
authors: Rutgeerts
authors: J
authors: J
authors: Satsangi
authors: A N
authors: AN
authors: Shelling
authors: K A
authors: KA
authors: Siminovitch
authors: H-P
authors: HP
authors: Török
authors: M
authors: M
authors: Tremelling
authors: S
authors: S
authors: Vermeire
authors: M R
authors: MR
authors: Valvano
authors: H
authors: H
authors: Witt
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003424:Crohn Disease / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D016017:Odds Ratio; D012737:Sex Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics; D044465:White People / Q000235:genetics*
chemical_list: C114461:DLG5 protein, human; D008565:Membrane Proteins; D025521:Tumor Suppressor Proteins