Plasmapheresis and corticosteroid treatment for persistent jaundice after successful drainage of common bile duct stones by endoscopic retrograde cholangiography.
Prolonged cholestasis is a very rare complication of endoscopic retrograde cholangiography (ERC). Only few cases with this complication are reported in the English literature. We report persisting cholestatic jaundice in a 73-year old man after successful therapeutic ERC for choledocholithiasis. Serologic tests for viral and autoimmune hepatitis were all negative. A second-look ERC was normal also. He denied any medication except for prophylaxis given intravenous 1 g ceftriaxone prior to the ERC procedure. After an unsuccessful trial with ursodeoxycholic acid and cholestyramine for 2 wk, this case was efficiently treated with corticosteroids and plasmapheresis. His cholestatic enzymes became normal and intense pruritus quickly resolved after this treatment which lasted during his follow-up period. We discussed the possible mechanisms and treatment alternatives of intrahepatic cholestasis associated with the ERC procedure.
Saritas
Ulku
U
Gastroneterology Department, Süleyman Demirel University, School of Medicine, Turkey.
Aydin
Bunyamin
B
Ustundag
Yucel
Y
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000368:Aged; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D042883:Choledocholithiasis / Q000150:complications / Q000628:therapy*; D004322:Drainage / Q000379:methods; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology* / Q000628:therapy*; D008297:Male; D010956:Plasmapheresis / Q000379:methods*
D000305:Adrenal Cortex Hormones
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