[Characterization of the HtrA family of proteins].
The HtrA family of proteins consists of evolutionary conserved serine proteases, which are homologues of the HtrA protein from a model bacterium Escherichia coli. They are widely distributed among organisms, prokaryotic as well as eukaryotic including humans. HtrA proteins participate in defense against stresses causing aberrations in protein structure, for example heat or oxidative stress. At least four human homologues have been identified. They are involved in cell growth and differentiation, apoptosis, and disturbances in their function may induce carcinogenesis, arthritic and neurodegenerative disorders. This article summarizes recent studies regarding the HtrA family of proteins, their structure, regulation and function. It also presents practical applications of this knowledge and perspective of its use in the future.
Zurawa-Janicka
Dorota
D
Katedra Biochemii, Instytut Biologii, Uniwersytet Gdański, Gdańsk. zurawa@biotech.univ.gda.pl
Narkiewicz
Joanna
J
Lipińska
Barbara
B
D049069:ATP-Dependent Proteases / Q000737:chemistry / Q000378:metabolism*; D020816:Amino Acid Motifs; D017209:Apoptosis / Q000502:physiology; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism*; D000074289:High-Temperature Requirement A Serine Peptidase 1; D000074923:High-Temperature Requirement A Serine Peptidase 2; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism; D033903:Periplasmic Proteins / Q000737:chemistry / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D012697:Serine Endopeptidases / Q000737:chemistry / Q000378:metabolism*
D006360:Heat-Shock Proteins; D051034:Inhibitor of Apoptosis Proteins; D024101:Mitochondrial Proteins; D033903:Periplasmic Proteins; D049069:ATP-Dependent Proteases; C061682:DegP protease; D000074289:High-Temperature Requirement A Serine Peptidase 1; C474012:HTRA1 protein, human; D012697:Serine Endopeptidases; D000074923:High-Temperature Requirement A Serine Peptidase 2