Mortality due to dapsone hypersensitivity syndrome complicating multi-drug therapy for leprosy in Nepal.
Dapsone is a component of multi-drug therapy (MDT) for the treatment of all types of leprosy. It is known that dapsone hypersensitivity syndrome (DHS) complicates the treatment in a proportion of patients. We performed a retrospective study of patients commenced on MDT between 1990 and 2006; 2% developed DHS and 0.25% died due to DHS.
Pandey
B
B
Department of Medicine, Anandaban Hospital, PO Box 151 Kathmandu, Nepal.
Shrestha
K
K
Lewis
J
J
Hawksworth
R A
RA
Walker
S L
SL
D000293:Adolescent; D000328:Adult; D000368:Aged; D003622:Dapsone / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000453:epidemiology / Q000209:etiology / Q000401:mortality*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007918:Leprosy / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009390:Nepal / Q000453:epidemiology
D007917:Leprostatic Agents; D003622:Dapsone