Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions.
The apolipoprotein E (apoE) polymorphism is emerging as a uniquely important genetic modifier that affects functional outcome from both acute and chronic neurological injuries. Recent attention has focused on common denominator mechanisms by which apoE might affect brain injury and/or brain repair responses in clinically diverse diseases. Although endogenous apoE likely serves several adaptive functions in the injured CNS, there is growing evidence that its effect on modifying brain inflammatory responses and providing protection from excitotoxic injury may be central to its protective properties. A more complete understanding of the role that apoE plays in the injured brain has led to novel therapeutic strategies for both acute and chronic neurological disease.
Laskowitz
Daniel T
DT
Duke University Medical Center, Department of Medicine (Neurology), Box 2900, Durham, NC 27710, USA. danl@neuro.duke.edu
Vitek
Michael P
MP
D000818:Animals; D001057:Apolipoproteins E / Q000502:physiology* / Q000627:therapeutic use; D016923:Cell Death / Q000235:genetics; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology* / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*; D010597:Pharmacogenetics / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics
D001057:Apolipoproteins E; D018836:Inflammation Mediators