title: Reduced availability of serotonin transporters in obsessive-compulsive disorder correlates with symptom severity - a [11C]DASB PET study.
abstract: Reduced availability of brainstem serotonin transporters (5-HTT) has been observed in vivo in obsessive-compulsive disorder (OCD). However, results vary and may be influenced by competition with endogenous serotonin. Using positron emission tomography (PET) and [11C]DASB, a specific 5-HTT ligand that showed no competition with serotonin for 5-HTT binding in vitro, we tested the hypothesis that 5-HTT availability is reduced in OCD patients and correlated with OCD severity. METHODS. 5-HTT availability in the thalamus and the midbrain was measured in nine drug-free OCD patients and compared with 19 healthy controls, matched for the individual combination of 5-HTT genotype, gender and smoking status. OCD severity was assessed with the Yale-Brown obsessive compulsive scale (Y-BOCS). RESULTS. 5-HTT availability was significantly reduced in the thalamus and midbrain of OCD patients. Age and 5-HTT in the thalamus explained 83% of OCD severity in patients that were drug-free for at least 1 year. CONCLUSION. This PET study confirms a central role of the serotonergic system, particularly the thalamus in the pathogenesis of obsessive compulsive disorder.
authors: Department of Nuclear Medicine, University of Tübingen, Tübingen, Germany.
authors: M
authors: M
authors: Reimold
authors: M N
authors: MN
authors: Smolka
authors: A
authors: A
authors: Zimmer
authors: A
authors: A
authors: Batra
authors: A
authors: A
authors: Knobel
authors: C
authors: C
authors: Solbach
authors: A
authors: A
authors: Mundt
authors: H U
authors: HU
authors: Smoltczyk
authors: D
authors: D
authors: Goldman
authors: K
authors: K
authors: Mann
authors: G
authors: G
authors: Reischl
authors: H-J
authors: HJ
authors: Machulla
authors: R
authors: R
authors: Bares
authors: A
authors: A
authors: Heinz
mesh_terms: D000328:Adult; D000367:Age Factors; D000814:Aniline Compounds; D001921:Brain / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000378:metabolism*; D049268:Positron-Emission Tomography; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D012737:Sex Factors; D012907:Smoking; D013440:Sulfides
chemical_list: C412822:3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile; D000814:Aniline Compounds; D050486:Serotonin Plasma Membrane Transport Proteins; D013440:Sulfides
references: Mol Psychiatry. 2008 Jun;13(6):606-13, 557
references: 18268503
references: Alcohol Clin Exp Res. 2005 Jan;29(1):8-16
references: 15654286
references: J Cereb Blood Flow Metab. 2003 Sep;23 (9):1096-112
references: 12973026
references: Am J Hum Genet. 2006 May;78(5):815-26
references: 16642437
references: Arch Gen Psychiatry. 1990 Jun;47(6):577-85
references: 2112374
references: J Cereb Blood Flow Metab. 2007 Sep;27(9):1533-9
references: 17519979
references: Synapse. 2005 Mar 1;55(3):164-75
references: 15605360
references: Arch Neurol. 1993 Aug;50(8):873-80
references: 8352676
references: Br J Psychiatry. 1995 Feb;166(2):244-50
references: 7728370
references: Synapse. 1993 Apr;13(4):295-309
references: 7683143
references: Arch Gen Psychiatry. 1980 Nov;37(11):1289-94
references: 6159865
references: Am J Psychiatry. 2004 Dec;161(12 ):2201-6
references: 15569890
references: Arch Gen Psychiatry. 1989 Nov;46(11):1006-11
references: 2684084
references: Biol Psychiatry. 2000 Apr 1;47(7):643-9
references: 10745057
references: J Neurophysiol. 2002 Apr;87(4):2124-36
references: 11929930
references: Biol Psychiatry. 2007 Aug 15;62(4):327-31
references: 17210141
references: Psychiatry Res. 1998 Jun 2;79(1):11-20
references: 9676822
references: J Neural Transm Suppl. 2004;(68):29-38
references: 15354387
references: Biol Psychiatry. 2003 Dec 15;54(12 ):1406-13
references: 14675805
references: Pharmacopsychiatry. 1999 Nov;32(6):223-9
references: 10599930
references: Arch Gen Psychiatry. 1987 Nov;44(11):946-51
references: 3675134
references: J Neurochem. 2004 Sep;90(5):1218-26
references: 15312176
references: J Clin Psychiatry. 1994 Mar;55 Suppl:32-7
references: 7915713
references: Arch Gen Psychiatry. 1961 Jun;4:561-71
references: 13688369
references: Neuropsychopharmacology. 2007 Aug;32(8):1661-8
references: 17192774
references: Prog Neurobiol. 1992 Oct;39(4):337-88
references: 1354387
references: Biol Psychiatry. 2003 Dec 15;54(12 ):1414-21
references: 14675806
references: Synapse. 2001 Sep 15;41(4):275-84
references: 11494398
references: J Nucl Med. 2005 May;46(5):745-51
references: 15872345
references: Science. 1996 Aug 30;273(5279):1225-7
references: 8703056
references: Psychiatry Res. 2005 Oct 30;140(1):63-72
references: 16213689
references: Biol Psychiatry. 1985 Nov;20(11):1174-88
references: 2413912
references: Biol Psychiatry. 2005 Nov 15;58(10 ):825-30
references: 16026765
references: J Nucl Med. 2004 Apr;45(4):682-94
references: 15073266
references: Arch Gen Psychiatry. 1989 Nov;46(11):1012-6
references: 2510699
references: Am J Psychiatry. 1998 Aug;155(8):1023-8
references: 9699688
references: Arch Gen Psychiatry. 1992 Sep;49(9):681-9
references: 1514872
references: Arch Gen Psychiatry. 1987 Mar;44(3):211-8
references: 3493749
references: Neurology. 1998 Oct;51(4):1069-74
references: 9781531
references: Neuropsychopharmacology. 2000 Feb;22(2):133-9
references: 10649826
references: Annu Rev Neurosci. 1986;9:357-81
references: 3085570
references: Pharmacopsychiatry. 2002 Jul;35(4):127-34
references: 12163982
references: Eur J Nucl Med. 2000 Nov;27(11):1719-22
references: 11105830
references: J Neural Transm (Vienna). 2007;114(5):635-9
references: 17225932
references: Biol Psychiatry. 1987 Jun;22(6):667-87
references: 3036259
references: BMC Biol. 2005 Feb 14;3:4
references: 15710042
references: Science. 1996 Nov 29;274(5292):1527-31
references: 8929413