An examination of the rheological and mucoadhesive properties of poly(acrylic acid) organogels designed as platforms for local drug delivery to the oral cavity.
This study examined the rheological/mucoadhesive properties of poly(acrylic acid) PAA organogels as platforms for drug delivery to the oral cavity. Organogels were prepared using PAA (3%, 5%, 10% w/w) dissolved in ethylene glycol (EG), propylene glycol (PG), 1,3-propylene glycol (1,3-PG), 1,5-propanediol (1,5-PD), polyethylene glycol 400 (PEG 400), or glycerol. All organogels exhibited pseudoplastic flow. The increase in storage (G') and loss (G'') moduli of organogels as a function of frequency was minimal, G'' was greater than G'' (at all frequencies), and the loss tangent <1, indicative of gel behavior. Organogels prepared using EG, PG, and 1,3-propanediol (1,3-PD) exhibited similar flow/viscoelastic properties. Enhanced rheological structuring was associated with organogels prepared using glycerol (in particular) and PEG 400 due to their interaction with adjacent carboxylic acid groups on each chain and on adjacent chains. All organogels (with the exception of 1,5-PD) exhibited greater network structure than aqueous PAA gels. Organogel mucoadhesion increased with polymer concentration. Greatest mucoadhesion was associated with glycerol-based formulations, whereas aqueous PAA gels exhibited the lowest mucoadhesion. The enhanced network structure and the excellent mucoadhesive properties of these organogels, both of which may be engineered through choice of polymer concentration/solvent type, may be clinically useful for the delivery of drugs to the oral cavity.
Jones
David S
DS
School of Pharmacy, Medical Biology Centre, The Queen's University of Belfast, 97, Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK. d.jones@qub.ac.uk
Muldoon
Brendan C O
BC
Woolfson
A David
AD
Sanderson
F Dominic
FD
D000180:Acrylic Resins / Q000737:chemistry* / Q000378:metabolism; D000268:Adhesiveness; D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004339:Drug Compounding; D004548:Elasticity; D019855:Ethylene Glycol / Q000737:chemistry; D005782:Gels; D005990:Glycerol / Q000737:chemistry; D008956:Models, Chemical; D009055:Mouth / Q000378:metabolism*; D009077:Mucins / Q000737:chemistry* / Q000378:metabolism; D009991:Oscillometry; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D019946:Propylene Glycol / Q000737:chemistry; D012212:Rheology; D012997:Solvents / Q000737:chemistry; D013314:Stress, Mechanical; D013678:Technology, Pharmaceutical / Q000379:methods*; D014783:Viscosity
D000180:Acrylic Resins; D004337:Drug Carriers; D005782:Gels; D009077:Mucins; D004364:Pharmaceutical Preparations; D012997:Solvents; D011092:Polyethylene Glycols; C006903:carbopol 940; D019946:Propylene Glycol; D019855:Ethylene Glycol; D005990:Glycerol