title: [Visceral morphofunctional changes in guinea-pigs during long-term administration of antituberculous agents].
abstract: Antituberculous drugs (ATD) can adversely affect the kidney and liver. Visceral morphological and histochemical changes were studied in guinea-pigs long receiving a combination of 2 or 5 ATDs. The use of ATDs caused changes at all levels (organ, tissue, and cell). The liver exhibited a pattern of microvesicular steatosis and the kidneys showed hyaline dropwise degeneration. The activity of NADN-DH, NADRH-GH, lactate dehydrogenase, glucose-6-phosphate dehydrogenase lowered in the liver and kidneys, so did the activity of acid phosphatase in the alveolar macrophages. More pronounced changes were detected after the use of 5 ATDs.
authors: S B
authors: SB
authors: Vol'f
authors: R E
authors: RE
authors: Lis
authors: L E
authors: LE
authors: Vinogradova
authors: O N
authors: ON
authors: Shinkevich
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005234:Fatty Liver / Q000139:chemically induced* / Q000473:pathology; D005500:Follow-Up Studies; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000995:Antitubercular Agents