The influence of dinoprostone on uterine cervix ripening and the course of labor.
OBJECTIVE
The aim of the study was to estimate the influence of dinoprostone in two different forms on the ripening of uterine cervix and the course of labor.


METHODS
128 pregnant women with indications for labor induction and uterine cervix Bishop's scores <6, divided into 2 groups: I--62 patients who had dinoprostone in the form of a gel applied for labor preinduction; II--66 women who were administered dinoprostone in the form of vaginal inserts. The effectiveness of both forms of dinoprostone were estimated and compared.


RESULTS
No differences in Bishop's score changes were noticeable between the groups after 6-8 hours from application, however they were significant at the beginning of induction: I - 7.8+/-1.3 vs. II - 6.9+/-1.6 (p=0.0007). Almost half of the patients from group II had spontaneous contractions and required no labor induction at all. The average time from dinoprostone application till delivery was shorter in group II.


CONCLUSIONS
Dinoprostone vaginal inserts seem to influence both uterine cervix and muscle, while gel-prepare uterine cervix for delivery more effectively.
Wielgos
Miroslaw
M
1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Plac Starynkiewicza 1/3, 02-015 Warsaw, Poland. mwielgos@amwaw.edu.pl
Szymusik
Iwona
I
Kosinska-Kaczynska
Katarzyna
K
Suchonska
Barbara
B
Kaminski
Pawel
P
Banaszek-Wysoczanska
Agnieszka
A
Bomba-Opon
Dorota
D
Szpotanska
Monika
M
D002584:Cervix Uteri / Q000187:drug effects / Q000502:physiology*; D017364:Collagenases / Q000378:metabolism; D015232:Dinoprostone / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009215:Myometrium / Q000187:drug effects / Q000502:physiology; D010120:Oxytocics / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011509:Proteoglycans / Q000378:metabolism; D013488:Suppositories; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects / Q000502:physiology; D014622:Vaginal Creams, Foams, and Jellies
D010120:Oxytocics; D011509:Proteoglycans; D013488:Suppositories; D014622:Vaginal Creams, Foams, and Jellies; D017364:Collagenases; D015232:Dinoprostone