Pathophysiology and types of dyslipidemia in PCOS.
Polycystic ovary syndrome (PCOS) is an endocrinopathy that affects women of reproductive age. PCOS shares components with the metabolic syndrome and has broad health implications. Lipid abnormalities, including elevated low-density lipoprotein (LDL), triglyceride levels and decreased high-density lipoprotein (HDL), are often found in women with PCOS. It is clear that obesity, insulin resistance and hyperandrogenism coexist in PCOS, and have independent and interactive effects on dyslipidemia, although the mechanisms of these interactions remain elusive. Here, we review the types and pathophysiology of dyslipidemia associated with PCOS and its related conditions.
Diamanti-Kandarakis
Evanthia
E
Endocrine Section, 1st Department of Medicine, Laiko General Hospital, University of Athens Medical School, GR-11527 Athens, Greece. akandara@otenet.gr
Papavassiliou
Athanasios G
AG
Kandarakis
Stylianos A
SA
Chrousos
George P
GP
D050171:Dyslipidemias / Q000097:blood / Q000145:classification / Q000503:physiopathology*; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000150:complications / Q000503:physiopathology; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008954:Models, Biological; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000503:physiopathology*
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL