title: Incidence of Helicobacter pylori recurrent infection and associated factors in Thailand.
abstract: OBJECTIVE
  To determine the incidence of H. pylori recurrent infection after successful eradication in 4-year follow-up study, and to evaluate the influencing factors for re-infection.
  
  
  METHODS
  Thirty-seven patients (age range 20-74 years; average 49.06 +/- 14.03 years) were recruited of which 64.9% were females. The H. pylori infection was proved to be successfully eradicated in all patients. Annually, urea breath test (UBT) was assessed to determine H. pylori status after eradication. Age, sex, eating habit, water drinking, number of children, and treatment regimens against H. pylori were recorded A breath test was also performed on the patient's spouse.
  
  
  RESULTS
  The H. pylori recurrence occurred in 5/37 (13.51%) of patients observed There were two patients in the first year, one patient each in the second, third, and fourth year The cumulative re-infection rate was 5.41% at 1-year 8.11% at 2-year 10.81% at 3-year and 13.51% at 4-year H. pylori infection of spouse was also frequent (80%). Even if the spouse was infected, 88.89% of patients will remain uninfected after 4-years of H. pylori eradication. No influencing factor for infection recurrence was detected.
  
  
  CONCLUSIONS
  The risk of re-infection after H. pylori eradication was low in Thai patients after 4-year follow up. Annual re-infection rate was 3.38%. No dependent factors were associated with a recurrence.
authors: Department of Physiology, Faculty of Medicine, Chulalongkorn University Bangkok, Thailand. thongngam007@yahoo.com
authors: Duangporn
authors: D
authors: Thong-Ngam
authors: Varocha
authors: V
authors: Mahachai
authors: Pinit
authors: P
authors: Kullavanijaya
mesh_terms: D000328:Adult; D000368:Aged; D001944:Breath Tests; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D017211:Treatment Failure