Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family.
Reversible phosphorylation of cytoskeletal and cytoskeleton-associated proteins is a significant element of endothelial barrier function regulation. Therefore, understanding the mechanisms of phosphorylation/dephosphorylation of endothelial cell cytoskeletal proteins is vital to the treatment of severe lung disorders such as high permeability pulmonary edema. In vivo, there is a controlled balance between the activities of protein kinases and phosphatases. Due to various external or internal signals, this balance may be shifted. The actual balances at a given time alter the phosphorylation level of certain proteins with appropriate physiological consequences. The latest information about the structure and regulation of different types of Ser/Thr protein phosphatases participating in the regulation of endothelial cytoskeletal organization and barrier function will be reviewed here.
Csortos
Csilla
C
Department of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, Illinois, USA.
Kolosova
Irina
I
Verin
Alexander D
AD
D000818:Animals; D002199:Capillary Permeability / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology* / Q000648:ultrastructure*; D042783:Endothelial Cells / Q000378:metabolism* / Q000648:ultrastructure*; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000502:physiology*
D010749:Phosphoprotein Phosphatases