title: Would pancreas duct-epithelium-derived stem/progenitor cells enhance islet allograft survival by means of islets recruitment and tolerance induction in Edmonton protocol era?
abstract: Rates of insulin independence at 1 year with current Edmonton protocol are impressive. However, obstacles such as the restricted availability of donor pancreas, coupled with recipient's pharmacologic immunosuppression, have lent strong impetus to the search for new sources of insulin-producing cells. But work with stem cells has not yet produced cells with the phenotype of true beta cells. Recently the data have shown that the presence of duct-epithelium in clinical islet transplantation may improve the long-term metabolic outcome. The underlying mechanisms are not well understood. The pancreatic duct-epithelium has been considering as a pool of pancreatic stem/progenitor cells, cytokeratin-19 positive stem cells, which have been proved to be capable of differentiating into endocrine cells and inducing immune tolerance. Based on these findings, we speculate that pancreatic stem/progenitor cells derived from ductal epithelium may enhance islet allograft survival through two aspects: islet recruitment and tolerance induction. The proposition may have clues on the further improvement in clinical islet transplantation long-term outcome.
authors: Department of Hepatobiliary and Pancreatic Surgery, Qilu Hospital of Shandong University, 250012 Jinan, PR China.
authors: Bo
authors: B
authors: Chen
authors: Lei
authors: L
authors: Wang
authors: Sanyuan
authors: S
authors: Hu
authors: Liguang
authors: L
authors: Zhou
authors: Rong
authors: R
authors: Wang
authors: Mitchell S
authors: MS
authors: Wachtel
authors: Eldo E
authors: EE
authors: Frezza
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D004847:Epithelial Cells / Q000166:cytology* / Q000276:immunology; D006085:Graft Survival / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007108:Immune Tolerance; D050417:Insulin-Secreting Cells / Q000276:immunology; D016381:Islets of Langerhans Transplantation / Q000276:immunology / Q000379:methods* / Q000502:physiology*; D016031:Liver Transplantation / Q000276:immunology; D010183:Pancreatic Ducts / Q000166:cytology* / Q000276:immunology; D014184:Transplantation, Homologous; D016896:Treatment Outcome