Factors in the pathophysiology of the liver ischemia-reperfusion injury.
Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic transplantation, hepatic resection, and trauma. The signaling events contributing to local hepatocellular damage are diverse and complex and involve the interaction between hepatocytes, sinusoidal endothelial cells, Kupffer cells, as well as infiltrating neutrophils, macrophages, and platelets. Signaling mediators include cytokines, reactive oxygen and nitrogen species, calcium, complement, and several transcription factors. The purpose of this review article was to summarize the factors that contribute to the pathophysiology of hepatic ischemia-reperfusion injury.
Montalvo-Jave
Eduardo E
EE
Department of Surgery, National Autonomous University of Mexico, Mexico City, Mexico.
Escalante-Tattersfield
Tomas
T
Ortega-Salgado
Jose A
JA
Piña
Enrique
E
Geller
David A
DA
D000818:Animals; D017209:Apoptosis; D001792:Blood Platelets / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007728:Kupffer Cells / Q000502:physiology; D008099:Liver / Q000098:blood supply*; D008833:Microcirculation; D009336:Necrosis; D009504:Neutrophils / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000209:etiology* / Q000503:physiopathology
D016207:Cytokines; D017382:Reactive Oxygen Species
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