Methylphenidate-induced changes in cerebral hemodynamics measured by functional near-infrared spectroscopy.
The aim of the present preliminary study was to evaluate the feasibility of measuring cerebral hemodynamic effects of a clinical dose of methylphenidate by near-infrared spectroscopy in 10 boys (median age, 10.7 years; range, 8.6-11.8 years) with developmental attention-deficit/hyperactivity disorder (ADHD). Using a Trail Making Test known to activate the left dorsolateral prefrontal cortex, cerebral hemodynamic changes show a lower increase of cerebral blood volume in the right prefrontal cortex (P = .033) and a lower increase of the tissue oxygenation index in the left prefrontal cortex (P = .015) in the condition after intake of methylphenidate compared with a drug-naive situation. A lower increase of the tissue oxygenation index indicates a changing regional oxygen metabolism and consumption induced by methylphenidate. Near-infrared spectroscopy is a sensitive tool for measuring pharmacological effects of methylphenidate on the cerebral hemodynamics.
Weber
Peter
P
Department of Neuropediatrics and Developmental Neurology, University Children's Hospital Basel, Roemergasse 9, CH-4005 Basel, Switzerland. peter.weber@unibas.ch
Lütschg
Jürg
J
Fahnenstich
Hubert
H
D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001288:Attention / Q000187:drug effects* / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002648:Child; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000098:blood supply / Q000187:drug effects*; D019265:Spectroscopy, Near-Infrared
D000697:Central Nervous System Stimulants; D008774:Methylphenidate