title: Effect of a fluoridated food item on enamel in situ.
abstract: After the consumption of food items prepared with fluoridated salt elevated fluoride concentrations can be observed in saliva, whereby enamel mineralization is supposed to be positively affected. The aim of this double-blind (with respect to fluoride), placebo-controlled, randomized, cross-over study was to evaluate the effects of the consumption of either a fluoridated (effect) or a placebo food item on the mineral content of sound and pre-demineralized human enamel in situ. During both phases of the study 8 enamel specimens in each of 10 intraoral appliances were positioned, either recessed or flush with the acrylic surface. One of the flanges was brushed twice daily with fluoride-free toothpaste prior to the storage of the appliance in sucrose solution. The subjects were asked to refrain from other sources of fluorides except for the consumption of either a highly fluoride-containing (0.5 mg) or a placebo cookie (3 times daily) during the respective study phase. Mineral content and lesion depth were measured in the enamel specimens and fluoride concentrations in saliva and urine. Significantly increased urinary and salivary (immediately after food consumption) fluoride concentrations compared to baseline were observed during the effect phase. In the absence of fluorides more pronounced demineralization was observed, especially for the recessed specimens of both surface conditions. Brushing was shown to inhibit demineralization, particularly during the placebo phase. In conclusion, fluorides added to food items seem to be efficacious to inhibit enamel demineralization in plaque-covered enamel but might be less effective if oral hygiene is adequate.
authors: Department of Operative Dentistry and Periodontology, University School of Dental Medicine, Campus Benjamin Franklin, Charité-Universitatsmedizin Berlin, Berlin, Germany. hendrik.meyer-lueckel@charite.de
authors: H
authors: H
authors: Meyer-Lueckel
authors: K
authors: K
authors: Bitter
authors: A M
authors: AM
authors: Kielbassa
mesh_terms: D002327:Cariostatic Agents / Q000494:pharmacology*; D018592:Cross-Over Studies; D004245:DMF Index; D003743:Dental Enamel / Q000187:drug effects*; D003773:Dental Plaque / Q000628:therapy; D004311:Double-Blind Method; D005459:Fluorides / Q000494:pharmacology* / Q000652:urine; D005527:Food, Fortified; D006801:Humans; D012463:Saliva / Q000737:chemistry; D017001:Tooth Demineralization / Q000188:drug therapy* / Q000517:prevention & control; D014099:Toothbrushing; D014100:Toothpastes / Q000737:chemistry
chemical_list: D002327:Cariostatic Agents; D014100:Toothpastes; D005459:Fluorides