title: Odontogenic differentiation of adipose-derived stem cells for tooth regeneration: necessity, possibility, and strategy.
abstract: Tooth regeneration using tissue engineering concepts is a promising biological approach to solving problems of tooth loss in elderly patients. The seeding cells, however, for tooth regeneration such as odontoblasts from dental germ, stem cells from dental pulp and deciduous teeth, and ectomesenchymal cells from the first branchial arch are difficult, even impossible to harvest in clinic. Bone marrow mesenchymal stem cells have odontogenic capacity, but their differentiation abilities significantly decrease with the increasing age of the donors. Therefore, the cells mentioned above are not practical in the clinical application of tooth regeneration in the old. Adipose derived stem cells have many clinical advantages over bone marrow mesenchymal stem cells, and their differentiation potential can be maintained with aging. Here we propose the hypothesis that adipose derived stem cells could be induced into odontogenic lineage and might be used as suitable seeding cells for tooth regeneration to replace the lost tooth of elderly patients.
authors: Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Sichuan Province, Chengdu 610041, China.
authors: Wei
authors: W
authors: Jing
authors: Ling
authors: L
authors: Wu
authors: Yunfeng
authors: Y
authors: Lin
authors: Lei
authors: L
authors: Liu
authors: Wei
authors: W
authors: Tang
authors: Weidong
authors: W
authors: Tian
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000368:Aged; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D009804:Odontoblasts / Q000502:physiology; D009805:Odontogenesis / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*; D014070:Tooth / Q000502:physiology*; D016388:Tooth Loss / Q000628:therapy