KIT-positive gastrointestinal stromal tumours in two Spanish ibex (Capra pyrenaica hispanica).
Gastrointestinal mesenchymal tumours from two Spanish ibex (Capra pyrenaica hispanica) were examined grossly, histologically and immunohistochemically. One neoplasm was a 1.5 kg tan multinodular cavitated mass in the forestomach. The other tumour was a firm mural mass 1.2 cm in diameter in the colon. Microscopically, both tumours were formed mainly by spindle shaped cells arranged in closely packed interlacing fascicles. Neoplastic cells in both tumours labelled positively for KIT (CD117), vimentin and alpha-smooth muscle actin. These findings suggest that both neoplasms were gastrointestinal stromal tumours and most likely to be derived from the interstitial cells of Cajal or their progenitor cells.
Velarde
Roser
R
Servei d'Ecopatologia de Fauna Salvatge, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Roser.Velarde@uab.es
Mentaberre
Gregorio
G
Sánchez
Joaquín
J
Marco
Ignasi
I
Lavín
Santiago
S
D000818:Animals; D017809:Fatal Outcome; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D015511:Goat Diseases / Q000378:metabolism / Q000473:pathology*; D006041:Goats; D007150:Immunohistochemistry / Q000662:veterinary; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D048608:Rupicapra; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology
D019009:Proto-Oncogene Proteins c-kit