Fenoldopam vs dopamine as a nephroprotective strategy during living donor kidney transplantation: preliminary data.
Fenoldopam is a selective DA1 agonist with potential nephroprotective capabilities. The aim of this study was to compare the nephroprotective effect of fenoldopam and dopamine during general anesthesia for living donor kidney transplantation.


METHODS
Forty donors enrolled in the study received a similar anesthetic and fluid protocol. The patients were randomly divided into group F (receiving 0.1 mg*kg-1*min-1 fenoldopam) versus group D (receiving "renal dose" 3 mg*kg-1*min-1 dopamine). The mean volume of infused fluids, diuresis, and urinary electrolytes (Na, K, Cl) at infusion start and 120 minutes later were studied.


RESULTS
Anthropometric parameters, administered anesthetics, mean infused volume, and urine outputs, did not show significant differences between the groups. Statistically significant differences were observed for urinary excretion of sodium, potassium, and chloride after 120 minutes of continuous fenoldopam infusion, with significant variations within groups for sodium only.


CONCLUSIONS
Fenoldopam compared with dopamine resulted in better nephroprotective effects. No adverse events were recorded, and side effects were minimal. Further studies are necessary to evaluate these data.
Sorbello
M
M
Anaesthesia and Intensive Care, University Hospital of Catania, Catania, Italy.
Morello
G
G
Paratore
A
A
Cutuli
M
M
Mistretta
G
G
Belluoccio
A A
AA
Veroux
M
M
Veroux
P
P
Macarone
M
M
Gagliano
M
M
Mangianeli
S
S
D000328:Adult; D004298:Dopamine / Q000627:therapeutic use*; D015259:Dopamine Agents / Q000627:therapeutic use*; D018818:Fenoldopam / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D016030:Kidney Transplantation / Q000502:physiology*; D019520:Living Donors; D008875:Middle Aged
D015259:Dopamine Agents; D018818:Fenoldopam; D004298:Dopamine