title: Inflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic mice.
abstract: This review addresses genes differentially expressed in the mammary gland transcriptome during the progression of mammary carcinogenesis in BALB/c mice that are transgenic for the rat neu (ERBB2, or HER-2/neu) oncogene (BALB-neuT664V-E mice). The Ingenuity knowledge database was used to characterize four functional association networks whose hub genes are directly linked to inflammation (specifically, the genes encoding IL-1beta, tumour necrosis factor, interferon-gamma, and monocyte chemoattractant protein-1/CC chemokine ligand-2) and are increasingly expressed during such progression. In silico meta-analysis in a human breast cancer dataset suggests that proinflammatory activation in the mammary glands of these mice reflects a general pattern of human breast cancer.
authors: Molecular Biotechnology Center, Department of Clinical and Biological Sciences, Via Nizza 52, 10126 Turin, Italy.
authors: Raffaele Adolfo
authors: RA
authors: Calogero
authors: Francesca
authors: F
authors: Cordero
authors: Guido
authors: G
authors: Forni
authors: Federica
authors: F
authors: Cavallo
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D018734:Genes, erbB-2 / Q000276:immunology*; D007249:Inflammation; D008321:Mammary Glands, Animal / Q000276:immunology*; D015674:Mammary Neoplasms, Animal / Q000235:genetics / Q000276:immunology / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic
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