[Role of survivin in mitosis].
Human survivin is a member of the IAP (Inhibitor of Apoptosis) family. It was reported that survivin expression is associated with drug resistance, cancer progression and low patient survival rate in many cancers. Survivin is implicated in both: inhibition of apoptosis and regulation of cell division. As a member of Chromosomal Passenger Complex (CPC) it is involved in sister chromatids segregation during mitosis. On the other hand, survivin plays an important role in the surveillance mechanism called mitotic spindle assembly checkpoint (MSAC) which regulates metaphase to anaphase transition during mitosis. Additionally, survivin is necessary for cytokinesis progression. The present review is a summary of survivin's functions, focused on its role in cell division in normal and cancer cells, as well as introduction to discussion about anticancer therapies based on survivin depletion.
Wolanin
Kamila
K
Pracownia Molekularnych Podstaw Starzenia, Zakład Biochemii, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego k.wolanin@nencki.gov.pl
Piwocka
Katarzyna
K
D000705:Anaphase; D000782:Aneuploidy; D017209:Apoptosis / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D048749:Cytokinesis / Q000502:physiology; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism; D008677:Metaphase; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D008938:Mitosis / Q000502:physiology*; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D011123:Polyploidy; D011485:Protein Binding; D020033:Protein Isoforms / Q000235:genetics; D017434:Protein Structure, Tertiary; D008941:Spindle Apparatus / Q000378:metabolism; D000077022:Survivin
C107489:BIRC5 protein, human; D002868:Chromosomal Proteins, Non-Histone; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D020033:Protein Isoforms; D000077022:Survivin