Effects of subchronic exposure to a 1439 MHz electromagnetic field on the microcirculatory parameters in rat brain.
THE AIM of this study was to investigate whether repeated exposure to radio frequency electromagnetic field (RF-EMF) of 1439 MHz affects the cerebral microcirculation, including blood-brain barrier function, in a rat brain.


METHODS
The head of the rat was exposed for four weeks (60 min/day, 5 days/week) to RF-EMF at 2.4 W/kg of brain averaged specific absorption rate (BASAR). Three microcirculatory parameters: blood-brain barrier permeability, leukocyte behavior and plasma velocity were measured before and after RF-EMF exposure using a closed cranial window method.


RESULTS
No extravasation of intravenously injected dyes from pial venules was found at any BASAR level. No significant changes in the number of endothelial-adhering leukocytes after exposure were found. The plasma velocity remained constant within the physiological range through each exposure.


CONCLUSIONS
These findings suggest that there were no effects on the cerebral microcirculation under the given RF-EMF exposure conditions.
Masuda
Hiroshi
H
Department of Environmental Health, National Institute of Public Health, Wako-shi, Saitama, Japan. msd@niph.go.jp
Ushiyama
Akira
A
Hirota
Shogo
S
Wake
Kanako
K
Watanabe
Soichi
S
Yamanaka
Yukio
Y
Taki
Masao
M
Ohkubo
Chiyoji
C
D000818:Animals; D001783:Blood Flow Velocity / Q000528:radiation effects; D001812:Blood-Brain Barrier / Q000528:radiation effects*; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D005456:Fluorescent Dyes / Q000493:pharmacokinetics; D007962:Leukocytes / Q000528:radiation effects; D008297:Male; D008833:Microcirculation / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013696:Temperature
D005456:Fluorescent Dyes