Sunitinib (sutent)-induced thyrotoxicosis due to destructive thyroiditis: a case report.
Numerous drugs have been associated with destructive thyroiditis (subacute thyroiditis). Sunitinib, a tyrosine kinase inhibitor employed in renal cell carcinoma and gastrointestinal stromal tumors, has recently been linked to destructive thyroiditis with resultant hypothyroidism. We report a patient with transient overt thyrotoxicosis followed by hypothyroidism, apparently related to sunitinib therapy.
Faris
Jason E
JE
Department of Internal Medicine, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA.
Moore
Allan F
AF
Daniels
Gilbert H
GH
D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy; D011758:Pyrroles / Q000009:adverse effects*; D000077210:Sunitinib; D013966:Thyroiditis / Q000139:chemically induced* / Q000150:complications; D013971:Thyrotoxicosis / Q000139:chemically induced*
D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib