Successful treatment of adult T-cell leukemia with unrelated cord blood transplantation.
This study reports the first well-documented case of adult T-cell leukemia (ATL) successfully treated with unrelated cord blood transplantation (UCBT). A 49-year-old woman was diagnosed with acute-type of ATL. Chemotherapy induced complete remission, but the human T-cell leukemia virus type 1 (HTLV-1) proviral load was detected in mononuclear cells of her peripheral blood. The patient received UCBT with a conditioning regimen consisting of total body irradiation, cytarabine, and cyclophosphamide. She remains in remission 30 months after UCBT and the HTLV-1 proviral load has fallen to undetectable levels. This result suggests that UCBT should be a therapeutic option for ATL patients who do not have suitable donors and those who urgently require treatment.
Takizawa
Jun
J
Division of Hematology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan. juntaki@med.niigata-u.ac.jp
Aoki
Sadao
S
Kurasaki
Tori
T
Higashimura
Masutaka
M
Honma
Keiichiro
K
Kitajima
Toshiki
T
Momoi
Akihito
A
Takahashi
Hidenobu
H
Nakamura
Naoya
N
Furukawa
Tatsuo
T
Aizawa
Yoshifusa
Y
D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D005260:Female; D005312:Fetal Blood / Q000276:immunology / Q000637:transplantation; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D006680:HLA Antigens