title: Immunohistochemical evaluation of the effect of lead exposure on subcommissural organ innervation and secretion in Shaw's Jird (Meriones shawi).
abstract: The secretory activity of subcommissural organ cells is controlled by various extrinsic and intrinsic factors. Lead has been recognised as a neurotoxic heavy metal, since it induces morphological and functional abnormalities in the brain. In this work, we examined the effect of lead exposure on the subcommissural organ (SCO), a brain gland known by its secretion of Reissner's fiber (RF) in cerebro-spinal fluid. Glycoprotein secretion and serotonin (5HT) innervation of the SCO was examined after acute and chronic lead exposures in the sub-desert rodent Meriones shawi. Lead exposures were achieved by, respectively, intra-peritoneal injection of 25 mg/kg body weight of lead acetate for 3 days and 0.5% of lead acetate in the drinking water over 4 months until adult age. 5HT and RF immunolabeling in the SCO revealed several serotoninergic fibers reaching the SCO and abundant secretory material. An increase in both 5HT innervation and secretory material of the SCO was recorded after both acute and chronic lead exposure. These results show that lead exposure affects the serotonergic innervation of the SCO. Moreover, the enhancement of SCO secretion suggests a role of this gland in neuroprotection and lead detoxification of the brain in Meriones shawi.
authors: Université Cadi Ayyad, Faculté des Sciences Semlalia, Laboratoire de Neurosciences, B.P. /2930, Marrakech, Morocco. m.bouyatas@ucam.ac.ma
authors: My M
authors: MM
authors: Bouyatas
authors: H
authors: H
authors: Gamrani
mesh_terms: D000208:Acute Disease; D000818:Animals; D000831:Animals, Newborn; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism; D002908:Chronic Disease; D005260:Female; D005849:Gerbillinae; D007150:Immunohistochemistry; D020263:Lead Poisoning, Nervous System / Q000473:pathology*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009942:Organometallic Compounds / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012701:Serotonin / Q000378:metabolism; D013351:Subcommissural Organ / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D009942:Organometallic Compounds; C108402:SCO-spondin; D012701:Serotonin; C008261:lead acetate