title: Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration.
abstract: Vertebrate gastrulation involves the coordinated movements of populations of cells. These movements include cellular rearrangements in which cells polarize along their medio-lateral axes leading to cell intercalations that result in elongation of the body axis. Molecular analysis of this process has implicated the non-canonical Wnt/Frizzled signaling pathway that is similar to the planar cell polarity pathway (PCP) in Drosophila. Here we describe a zebrafish mutant, colgate (col), which displays defects in the extension of the body axis and the migration of branchiomotor neurons. Activation of the non-canonical Wnt/PCP pathway in these mutant embryos by overexpressing DeltaNdishevelled, rho kinase2 and van gogh-like protein 2 (vangl2) rescues the extension defects suggesting that col acts as a positive regulator of the non-canonical Wnt/PCP pathway. Further, we show that col normally regulates the caudal migration of nVII facial hindbrain branchiomotor neurons and that the mutant phenotype can be rescued by misexpression of vangl2 independent of the Wnt/PCP pathway. We cloned the col locus and found that it encodes histone deacetylase1 (hdac1). Our previous results and studies by others have implicated hdac1 in repressing the canonical Wnt pathway. Here, we demonstrate novel roles for zebrafish hdac1 in activating non-canonical Wnt/PCP signaling underlying axial extension and in promoting Wnt-independent caudal migration of a subset of hindbrain branchiomotor neurons.
authors: Center for Molecular Neurobiology, Molecular, Cell and Developmental Biology Program, Department of Neuroscience, Ohio State University, 105 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA.
authors: Roopa M
authors: RM
authors: Nambiar
authors: Myron S
authors: MS
authors: Ignatius
authors: Paul D
authors: PD
authors: Henion
mesh_terms: D000818:Animals; D001369:Axons / Q000201:enzymology / Q000502:physiology*; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D002465:Cell Movement / Q000235:genetics / Q000502:physiology*; D016764:Cell Polarity / Q000235:genetics / Q000502:physiology; D056284:Histone Deacetylase 1; D006655:Histone Deacetylases / Q000235:genetics / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology*; D009154:Mutation; D012249:Rhombencephalon / Q000166:cytology / Q000196:embryology / Q000201:enzymology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D051153:Wnt Proteins / Q000235:genetics / Q000502:physiology*; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics; D029961:Zebrafish Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D051153:Wnt Proteins; D029961:Zebrafish Proteins; C488363:HDAC1 protein, zebrafish; D056284:Histone Deacetylase 1; D006655:Histone Deacetylases
references: J Neurosci. 2000 Jan 1;20(1):206-18
references: 10627598
references: Neurosci Lett. 1996 Sep 27;216(2):109-12
references: 8904795
references: Development. 2000 May;127(10):2227-38
references: 10769246
references: Nature. 2000 May 4;405(6782):76-81
references: 10811221
references: Mol Cell Biol. 2000 Sep;20(18):6882-90
references: 10958684
references: Genesis. 2000 Aug;27(4):159-73
references: 10992326
references: Nucleic Acids Res. 2001 Apr 1;29(7):1410-9
references: 11266540
references: Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3802-7
references: 11274398
references: Nat Genet. 2001 Jul;28(3):251-5
references: 11431695
references: Dev Biol. 2001 Jul 15;235(2):388-96
references: 11437445
references: Science. 2001 Aug 10;293(5532):1074-80
references: 11498575
references: Curr Opin Cell Biol. 2001 Oct;13(5):635-40
references: 11544034
references: Dev Cell. 2001 Aug;1(2):251-64
references: 11702784
references: Nature. 2001 Nov 15;414(6861):258-61
references: 11713509
references: Nat Cell Biol. 2002 Jan;4(1):20-5
references: 11780127
references: Dev Biol. 2002 Feb 15;242(2):149-60
references: 11820812
references: Curr Biol. 2002 Jun 4;12(11):876-84
references: 12062050
references: Dev Cell. 2002 Jun;2(6):695-706
references: 12062082
references: Nat Cell Biol. 2002 Aug;4(8):610-5
references: 12105418
references: Trends Genet. 2002 Sep;18(9):447-55
references: 12175805
references: Genes Dev. 2002 Aug 15;16(16):2073-84
references: 12183362
references: Biochem J. 2003 Mar 15;370(Pt 3):737-49
references: 12429021
references: Mech Dev. 2003 Apr;120(4):467-76
references: 12676324
references: Curr Biol. 2003 Apr 15;13(8):680-5
references: 12699626
references: Development. 2003 Sep;130(17):4037-46
references: 12874125
references: Curr Opin Pharmacol. 2003 Aug;3(4):344-51
references: 12901942
references: Dev Biol. 2004 Mar 1;267(1):165-80
references: 14975724
references: Development. 2004 Jun;131(12):2983-95
references: 15169759
references: Dev Biol. 2004 Oct 1;274(1):110-24
references: 15355792
references: Proc Can Cancer Conf. 1966;6:313-35
references: 5934780
references: Nature. 1989 Feb 2;337(6206):461-4
references: 2915691
references: Neuron. 1990 May;4(5):669-79
references: 2344406
references: Development. 1992 Dec;116(4):1021-32
references: 1295726
references: Development. 1993 Jun;118(2):417-25
references: 8223269
references: J Neurosci. 1994 Jun;14(6):3475-86
references: 7911517
references: Bioessays. 1995 May;17(5):423-30
references: 7786288
references: Development. 1995 Jun;121(6):1787-99
references: 7600994
references: Bioessays. 1995 Nov;17(11):931-9
references: 8526887
references: Development. 1996 Jan;122(1):271-80
references: 8565839
references: Dev Genet. 1996;18(1):11-7
references: 8742830
references: Development. 1996 Dec;123:67-80
references: 9007230
references: Development. 1996 Dec;123:143-51
references: 9007236
references: Development. 1996 Dec;123:451-60
references: 9007262
references: Development. 1996 Dec;122(12):3981-90
references: 9012518
references: EMBO J. 1997 Jun 2;16(11):3089-96
references: 9214626
references: Development. 1997 Jul;124(13):2633-44
references: 9217005
references: Development. 1998 Feb;125(3):393-406
references: 9425135
references: Cold Spring Harb Symp Quant Biol. 1997;62:227-34
references: 9598355
references: Dev Genes Evol. 1998 Jul;208(5):245-58
references: 9683740
references: Trends Genet. 1998 Nov;14(11):452-8
references: 9825673
references: Genes Dev. 1999 Sep 1;13(17):2218-30
references: 10485845
references: Mech Dev. 1999 May;83(1-2):27-37
references: 10507837
references: Nat Genet. 2005 May;37(5):537-43
references: 15852005
references: Mol Cell. 2005 May 13;18(4):483-90
references: 15893731
references: Development. 2005 Jul;132(13):3027-43
references: 15944187
references: Dev Dyn. 2005 Jul;233(3):883-9
references: 15895391
references: Dev Dyn. 2005 Oct;234(2):279-92
references: 16127722
references: Nature. 2000 Jan 6;403(6765):41-5
references: 10638745