High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survival.
There is sufficient evidence that human stomatin-like protein 2 (SLP-2) is a novel cancer-related gene. Its protein is overexpressed in many human cancers. SLP-2 can contribute to the promotion of cell growth, cell adhesion, and tumorigenesis in esophageal squamous cell carcinoma and lymph node metastasis in laryngeal squamous cell carcinoma. Immunohistochemical detection of SLP-2, estrogen and progesterone receptors, and HER-2/neu were performed on 263 cases of primary invasive breast cancer with a tissue microarray. Of 263 cases, 138 (52.5%) showed high expression of SLP-2 protein, and 125 (47.5%) showed low or absent expression. In addition, there were significant positive associations between tumor stage and size (P = .020), lymph node metastasis (P < .001), clinical stage (P < .001), distant metastasis (P = .002), and HER-2/neu protein expression (P = .037) and high-level SLP-2 expression. High-level SLP-2 expression was associated with decreased overall survival (P = .011) and was more often found in patients with tumors larger than 20 mm, lymph node metastasis, advanced clinical stage, distant metastasis, and HER-2/neu protein-positive expression. More important, lymph node metastasis, HER-2/neu-positive expression, and high-level SLP-2 expression were associated with significantly decreased survival.
Cao
Wenfeng
W
The Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Zhang
Bin
B
Liu
Yanxue
Y
Li
Hongtao
H
Zhang
Shiwu
S
Fu
Li
L
Niu
Yun
Y
Ning
Liansheng
L
Cao
Xuchen
X
Liu
Zhihua
Z
Sun
Baocun
B
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D001798:Blood Proteins / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D016019:Survival Analysis
D014408:Biomarkers, Tumor; D001798:Blood Proteins; D008565:Membrane Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; C406287:STOML2 protein, human