title: Noncardiac chest pain.
abstract: The clinical approach to the patient with unexplained chest pain is complex, as the history does not clearly separate cardiac from noncardiac etiologies. After a careful work-up has excluded coronary artery disease, a systematic search for an esophageal etiology is the next step. Gastroesophageal reflux disease (GERD) is most commonly associated with noncardiac chest pain and should be the first diagnosis pursued. A therapeutic trial of antisecretory therapy with proton-pump inhibitors is the most efficient initial approach to diagnosis and therapy of GERD-related chest pain and can easily be instituted by a cardiologist familiar with the optimal use of proton-pump inhibitors.
authors: Division of Gastroenterology, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.
authors: Philip O
authors: PO
authors: Katz
mesh_terms: D002637:Chest Pain / Q000188:drug therapy / Q000209:etiology*; D002986:Clinical Trials as Topic; D003937:Diagnosis, Differential; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors