Sympathoadrenergic overstimulation in Tako-Tsubo cardiomyopathy triggered by physical and emotional stress.
Tako-Tsubo cardiomyopathy (TTC) which is usually precipitated by profound emotional stress has been widely reported in the past. Recently, several co-morbidities have been found to be associated with this new cardiac entity. In this case we report from a female patient suffering from both, physical and emotional stress. After a persistent episode of severe abdominal pain due to acute cholecystitis and recurrent events of emotional stress, characteristic features of TTC could be documented. Histopathological analysis documented characteristic structural alterations including contraction band necrosis. Thus, this case confirms the hypothesis of an overstimulated sympthatoadrenergic system in TTC resulting from both, severe physical and emotional stress.
Nef
Holger M
HM
Möllmann
Helge
H
Hilpert
Pirmin
P
Masseli
Franz
F
Kostin
Sawa
S
Troidl
Christian
C
Rolf
Andreas
A
Dill
Thorsten
T
Weber
Michael
M
Hamm
Christian
C
Elsässer
A
A
D005260:Female; D006801:Humans; D008875:Middle Aged; D013312:Stress, Physiological / Q000502:physiology; D013315:Stress, Psychological / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D013564:Sympathetic Nervous System / Q000502:physiology; D054549:Takotsubo Cardiomyopathy / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology