title: Bone ingrowth in macroporous Bonelike for orthopaedic applications.
abstract: The aim of this study was to evaluate the biological behaviour of porous scaffold structures of Bonelike which is suitable for either direct clinical use or tissue engineering applications. Porous cylindrical specimens 8x10mm were implanted in the lateral aspect of the tibia of 13 patients (mean age 54 years), during osteotomy surgery for the treatment of medial compartment osteoarthritis of the knee. Implanted cylinders were retrieved at the same time as the removal of the blade plates at 3, 6, 9 and 12 months. Scanning electron microscopy and histological evaluations were performed to observe the biological responses of human bone tissue to porous Bonelike. The penetration depth was determined for all implantation periods, and after 6 months it was already possible to see new bone in the centre of the implanted cylinders, which gives 100% of penetration depth for all implantations periods except for 3 months when bone could only be seen in the peripherical region. Regarding the percentage of the area covered by new bone calculated from two-dimensional histological sections, values of 53+/-15, 76+/-12 and 88+/-9% were achieved for 6, 9 and 12 months, respectively. Due to its structural features porous Bonelike permitted effective vascularization and bone ingrowth, and therefore was fully osteointegrated as shown in the histological surveys. A slow biomaterial degradation with implantation time is envisaged since the material has displayed surface degradation. Bonelike scaffolds show potential for complete ingrowth of osseous tissue and restoration of vascularization throughout the defected site.
authors: FMUP - Faculdade de Medicina da Universidade do Porto, Hospital de São João, Largo Hernâni Monteiro, 4200 Porto, Portugal.
authors: M
authors: M
authors: Gutierres
authors: M A
authors: MA
authors: Lopes
authors: N
authors: N
authors: Sooraj Hussain
authors: A F
authors: AF
authors: Lemos
authors: J M F
authors: JM
authors: Ferreira
authors: A
authors: A
authors: Afonso
authors: A T
authors: AT
authors: Cabral
authors: L
authors: L
authors: Almeida
authors: J D
authors: JD
authors: Santos
mesh_terms: D000368:Aged; D018786:Bone Substitutes; D005260:Female; D006801:Humans; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D016348:Osseointegration; D010003:Osteoarthritis / Q000473:pathology / Q000601:surgery; D010027:Osteotomy; D019736:Prostheses and Implants; D013977:Tibia / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D023822:Tissue Engineering
chemical_list: D018786:Bone Substitutes