title: Studying alcohol elimination using the alcohol clamp method.
abstract: Researchers studying alcohol absorption and metabolism in humans have been aided by the alcohol clamp method, in which alcohol is administered intravenously, allowing study participants to achieve and maintain a target breath alcohol concentration (BrAC) for an extended period of time. This tool minimizes the variability in BrACs that occurs after alcohol consumption by administering alcohol at a dose and rate that is computed for each person individually. The alcohol clamp can be used to evaluate several influences on alcohol elimination, including gender, ethnicity, genetic variations in alcohol-metabolizing enzymes, and food consumption.
authors: Unit on Human Physiology and Pharmacokinetics, Laboratory of Clinical and Translational Studies, Division of Intramural Clinical and Biological Research, National Institute on AlcoholAbuse and Alcoholism, Bethesda, Maryland, USA.
authors: Vijay A
authors: VA
authors: Ramchandani
authors: Sean
authors: S
authors: O'Connor
mesh_terms: D000428:Alcohol Drinking / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D001944:Breath Tests / Q000379:methods*; D003250:Constriction; D000431:Ethanol / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D007262:Infusions, Intravenous / Q000295:instrumentation* / Q000379:methods; D008099:Liver / Q000000981:diagnostic imaging; D011859:Radiography
chemical_list: D000431:Ethanol; D000444:Aldehyde Dehydrogenase
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