Associations of IL-2 and IL-4 gene polymorphisms with psoriasis in the Korean population.
BACKGROUND
Psoriasis is association with an overexpression of T-helper cell type 1(Th1) cytokines and relative underexpression of Th2 cytokines. The cytokine production is under genetic control, and certain allelic variants of cytokine genes are associated with higher or lower cytokine production in vitro and in vivo.


OBJECTIVE
We aimed to evaluate association of cytokine genes polymorphisms with psoriasis in the Korean population.


METHODS
We investigated the polymorphisms of IL-2 -330, IL-4 -590, IL-4 receptor +1902, IL-10 -1082 and -819, and IFN-gamma intron 1 in 114 psoriasis patients and 281 healthy normal controls in Korean.


RESULTS
IL-2 -330*G and IL-4 -590*C alleles significantly increased in psoriasis patients, especially late-onset group, compared to the control. The combined effect of IL-2 -330*G and IL-4 -590*C showed that the positive combination of IL-2 -330*G and IL-4 -590*C alleles were more significantly associated with the late-onset group of psoriasis patients than the controls.


CONCLUSIONS
These results suggest that the genetic polymorphisms of IL-2 and IL-4 genes can be susceptible to psoriasis in Korean, especially late-onset psoriasis group.
Kim
Yang-Kyum
YK
Hemopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Pyo
Chul-Woo
CW
Choi
Hee-Baeg
HB
Kim
Su-Yeon
SY
Kim
Tae-Yoon
TY
Kim
Tai-Gyu
TG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D007723:Korea; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D019948:Receptors, Interleukin-4 / Q000235:genetics
D007376:Interleukin-2; D019948:Receptors, Interleukin-4; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma