MRI study of corpus callosum in patients with borderline personality disorder: a pilot study.
This pilot study examined the integrity of the corpus callosum in a sample of patients with borderline personality disorder (BPD), as abnormalities in inter-hemispheric communication could possibly be involved in illness pathophysiology. We utilized magnetic resonance imaging (MRI) signal intensity (SI) and morphometric measures. Ten BPD and 20 healthy control subjects were assessed for current and past Axis I and Axis II comorbidities and histories of childhood abuse. Regional CC SI and areas were measured with semi-automated software from three-dimensional gradient echo imaging scans. Analysis of covariance was conducted to evaluate the results. No significant differences were observed between BPD and controls in the SI or area of any CC region. Abnormalities in interhemispheric connectivity do not appear necessary for the development of BPD. Further studies with larger samples are needed to confirm this preliminary finding.
Zanetti
Marcus V
MV
Laboratory of Psychiatric Neuroimaging (LIM 21), Department and Institute of Psychiatry, University of São Paulo, São Paulo, SP, Brazil. marcus-zanetti@yahoo.com.br
Soloff
Paul H
PH
Nicoletti
Mark A
MA
Hatch
John P
JP
Brambilla
Paolo
P
Keshavan
Matcheri S
MS
Soares
Jair C
JC
D000293:Adolescent; D000328:Adult; D001883:Borderline Personality Disorder / Q000473:pathology*; D002648:Child; D002649:Child Abuse; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000473:pathology; D009412:Nerve Fibers / Q000473:pathology; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales