title: A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein.
abstract: This overview on the brain-serum relationship for drugs illustrates the importance of the drug transporter P-glycoprotein at the blood-brain barrier. Generally, an inverse relationship exists between the magnitude of the brain-serum ratio and the influence of P-glycoprotein. Concerning the pharmacogenomics of P-glycoprotein, no clear effect of single nucleotide polymorphisms (SNPs) has been demonstrated in humans.
authors: Section of Forensic Chemistry, Institute of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark.
authors: Thomas Broeng
authors: TB
authors: Ejsing
authors: Niels
authors: N
authors: Morling
authors: Kristian
authors: K
authors: Linnet
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism*; D001921:Brain; D006801:Humans; D051379:Mice; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism; D010599:Pharmacokinetics; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004364:Pharmaceutical Preparations