title: Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats.
abstract: Previous studies have suggested that intermittent exposure to hydrogenated vegetable shortening yields a binge/compensate pattern of feeding in rats. The present study was designed to assess whether rats would exhibit similar patterns of intake when given intermittent access to a nutritionally complete high-fat diet. Four groups of rats received varying exposure to either hydrogenated vegetable shortening or high-fat diet for 8 consecutive weeks. Animals were given daily and intermittent access to determine if the binge/compensate pattern of feeding was frequency dependent. At the conclusion of the study, body composition and plasma leptin levels were assessed to determine effects of diet and binge/compensate intake on endocrine alterations. As predicted, animals receiving intermittent access to high-fat diet displayed the binge/compensate pattern of feeding and appeared to compensate as a result of the caloric overload accompanying a particular binge episode. In addition, exposure to either shortening or high-fat diet led to alterations in body composition, while only exposure to shortening altered plasma leptin levels. These results suggest that binge-intake behavior occurs on a nutritionally complete high-fat diet and that this regimen is capable of altering both body composition and endocrine profile.
authors: University of Cincinnati, Department of Psychiatry, ML # 0506, Reading, OH 45237, United States. Jon.Davis@uc.edu
authors: Jon F
authors: JF
authors: Davis
authors: Susan J
authors: SJ
authors: Melhorn
authors: Jennifer D
authors: JD
authors: Shurdak
authors: Justin U
authors: JU
authors: Heiman
authors: Matthias H
authors: MH
authors: Tschöp
authors: Deborah J
authors: DJ
authors: Clegg
authors: Stephen C
authors: SC
authors: Benoit
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002032:Bulimia / Q000503:physiopathology* / Q000523:psychology*; D004041:Dietary Fats / Q000008:administration & dosage*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D002149:Energy Intake / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects* / Q000523:psychology; D020738:Leptin / Q000097:blood; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D004041:Dietary Fats; D020738:Leptin
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