title: Confirmation of elimination of lymphatic filariasis by an IgG4 enzyme-linked immunosorbent assay with urine samples in Yongjia, Zhejiang Province and Gaoan, Jiangxi Province, People's Republic of China.
abstract: A sensitive and specific IgG4 enzyme-linked immunosorbent assay (ELISA) with urine samples has been reported. To confirm elimination of bancroftian filariasis, the ELISA was used in a study conducted in Yongjia County and Gaoan City, People's Republic of China, where filariasis elimination was declared, with 10,409 students 5-16 years of age. The antibody positive rates were 0.08% in Yongjia and 0.34% in Gaoan. All positive samples were re-examined and found to be negative. Our results show that this ELISA is practical and useful for confirmation of the elimination of filariasis. If similar results are obtained in different filariasis-endemic countries, this method may be useful in global filariasis elimination programs.
authors: Department of Parasitology, Aichi Medical University School of Medicine, Nagakute, Aichi-ken 480-1195, Japan. macitoh@aichi-med-u.ac.jp
authors: Makoto
authors: M
authors: Itoh
authors: Weiping
authors: W
authors: Wu
authors: Dejian
authors: D
authors: Sun
authors: Linong
authors: L
authors: Yao
authors: Zhihong
authors: Z
authors: Li
authors: Mohammad Zahidul
authors: MZ
authors: Islam
authors: Renyu
authors: R
authors: Chen
authors: Kunzhao
authors: K
authors: Zhang
authors: Fengfei
authors: F
authors: Wang
authors: Shinan
authors: S
authors: Zhu
authors: Eisaku
authors: E
authors: Kimura
mesh_terms: D000293:Adolescent; D000818:Animals; D017179:Brugia pahangi / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004605:Elephantiasis, Filarial / Q000453:epidemiology / Q000469:parasitology / Q000652:urine*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000652:urine*; D008297:Male; D016036:Seroepidemiologic Studies
chemical_list: D007074:Immunoglobulin G