Interactions between iron(III)-hydroxide polymaltose complex and commonly used medications / laboratory studies in rats.
Simple iron salts, such as iron sulphate, often interact with food and other medications reducing bioavailability and tolerability. Iron(III)-hydroxide polymaltose complex (IPC, Maltofer) provides a soluble form of non-ionic iron, making it an ideal form of oral iron supplementation. The physicochemical properties of IPC predict a low potential for interactions. The effects of co-administration with aluminium hydroxide (CAS 21645-51-2), acetylsalicylic acid (CAS 50-78-2), bromazepam (CAS 1812-30-2), calcium acetate (CAS 62-54-4), calcium carbonate (CAS 471-34-1), auranofin (CAS 34031-32-8), magnesium-L-aspartate hydrochloride (CAS 28184-71-6), methyldopa sesquihydrate (CAS 41372-08-1), paracetamol (CAS 103-90-2), penicillamine (CAS 52-67-5), sulfasalazine (CAS 599-79-1), tetracycline hydrochloride (CAS 64-75-5), calcium phosphate (CAS 7757-93-9) in combination with vitamin D3 (CAS 67-97-0), and a multi-vitamin preparation were tested in rats fed an iron-deficient diet. Uptake of iron from radiolabelled IPC with and without concomitant medications was compared. None of the medicines tested had a significant effect on iron uptake. Iron-59 retrieval from blood and major storage organs was 64-76% for IPC alone compared with 59-85% following co-administration with other medications. It is concluded that, under normal clinical conditions, IPC does not interact with these medications.
Funk
Felix
F
Vifor (International) Inc., Research Department, St. Gallen, Switzerland.
Canclini
Camillo
C
Geisser
Peter
P
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002614:Chelating Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005290:Ferric Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*; D006454:Hemoglobins / Q000737:chemistry; D007501:Iron / Q000097:blood; D000090463:Iron Deficiencies; D007504:Iron Radioisotopes; D008297:Male; D051381:Rats
D002614:Chelating Agents; D005290:Ferric Compounds; D006454:Hemoglobins; D007504:Iron Radioisotopes; D007501:Iron; C013276:teferrol