Tomato-rich (Mediterranean) diet does not modify inflammatory markers.
BACKGROUND
The Mediterranean diet is rich in lycopene and has been reported to reduce cardiovascular events. The mechanism of prevention of cardiovascular events has not been clearly established. Our aim was to study the effects of a tomatoes-rich diet on markers of vascular inflammation.


METHODS
Plasma concentrations of E-selectin, intercellular adhesion molecule 1 (ICAM-1), and high sensitivity C-reactive protein (hs-CRP) were determined by ELISA in 103 apparently healthy volunteers. Volunteers were randomly assigned to two groups: 50 participants ate 300 g tomatoes daily for 1 month, and 53 participants ate their usual diet with tomatoes prohibited during that period. Markers of inflammation were measured before enrollment and 1 month after their assigned diet.


RESULTS
The two diet groups had similar baseline clinical characteristics and similar baseline levels of inflammatory markers. After 30 days of assigned diet concentrations of hs-CRP, E-selectin and ICAM-1 were unchanged compared with baseline in the tomato-rich diet. However, ICAM-1 concentration was increased in the regular diet group from 247.55+/-55 ng/ml to 264.71+/-60.42 ng/ml (P=0.01).


CONCLUSIONS
The mechanisms of benefit of the tomato-rich diet are not directly related to inhibition of markers of vascular inflammation.
Blum
Arnon
A
Department of Internal Medicine A, Baruch-PadehPoriya Medical Center, Lower Galilee, Israel. navablum@hotmail.com
Monir
Merei
M
Khazim
Khalid
K
Peleg
Aviva
A
Blum
Nava
N
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D038441:Diet, Mediterranean; D019040:E-Selectin / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D018551:Solanum lycopersicum; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D015415:Biomarkers; D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein