title: Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes.
abstract: BACKGROUND
  There is conflicting epidemiological evidence concerning an increase in risk of non-Hodgkin's lymphoma (NHL) associated with elevated blood levels of persistent organochlorine (OC) pesticides and polychlorobiphenyls (PCBs).
  
  
  METHODS
  We measured the concentration of 17 OC pesticides, including hexachlorobenzene (HCB), four lindane isomers (alpha-, beta-, gamma- and delta-hexachlorocyclohexane (HCH)), two chlordane species (heptachlor and oxy-chlordane), four cyclodiene insecticides (aldrin, dieldrin, endrin and mirex), six dichloro-diphenyl-trichloroethane (DDT) isomers and nine PCB congeners (PCBs 28, 52, 101, 118, 138, 153, 170, 180 and 194) in plasma samples of 377 subjects, including 174 NHL cases and 203 controls from France, Germany and Spain. The risk of NHL and its major subtypes associated with increasing blood levels of OC pesticides and PCBs was calculated using unconditional logistic regression.
  
  
  RESULTS
  Risk of NHL, diffuse large B cell lymphoma (DLBCL) and chronic lymphatic leukaemia (CLL) did not increase with plasma levels of HCB, beta-HCH, p,p'-dichloro-diphenyl-dichloroethylene (DDE), or total and individual PCBs or their functional groups, in the overall study population. Substantial heterogeneity in DLBCL risk associated with immunotoxic PCBs (p = 0.03) existed between the Spanish subgroup (odds ratio (OR) for immunotoxic PCB plasma level above the median vs below the median was 0.7, 95% CI 0.3 to 1.6) and the French and German subgroups combined (OR 3.2, 95% CI 0.9 to 11.5).
  
  
  CONCLUSIONS
  We did not find evidence of an association between NHL risk and plasma level of OC pesticides and PCBs.
authors: Department of Public Health, Occupational Health Section, Asse Didattico - Policlinico Universitario, SS 554, Km 4,500, 09042 Monserrato (Cagliari), Italy. coccop@pacs.unica.it
authors: P
authors: P
authors: Cocco
authors: P
authors: P
authors: Brennan
authors: A
authors: A
authors: Ibba
authors: S
authors: S
authors: de Sanjosé Llongueras
authors: M
authors: M
authors: Maynadié
authors: A
authors: A
authors: Nieters
authors: N
authors: N
authors: Becker
authors: M G
authors: MG
authors: Ennas
authors: M G
authors: MG
authors: Tocco
authors: P
authors: P
authors: Boffetta
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005602:France; D005858:Germany; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood; D016015:Logistic Models; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010573:Pesticide Residues / Q000097:blood*; D011078:Polychlorinated Biphenyls / Q000097:blood*; D018570:Risk Assessment / Q000379:methods; D013030:Spain
chemical_list: D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010573:Pesticide Residues; D011078:Polychlorinated Biphenyls