Cardiopulmonary adaptation in large for gestational age infants of diabetic and nondiabetic mothers.
OBJECTIVE
To compare cardiopulmonary adaptation in large for gestational age infants of diabetic and nondiabetic mothers.


METHODS
Color Doppler echocardiography was performed in 113 (22 large for gestational age infants of diabetic mothers, 21 of nondiabetic mothers and 70 adequate for gestational age newborns) full-term infants.


RESULTS
Pulmonary arterial pressure was significantly higher in infants of diabetic mothers than in those of nondiabetic mothers and normal infants at 24 h (38.5 vs. 32.5, and 35.5 mmHg, respectively). However, slow fall in this parameter was shown in all large for gestational age infants. Open ductus arteriosus was frequent in all large for gestational age infants, but its closure was significantly delayed in infants of diabetic mothers. Septal hypertrophy was higher in infants of diabetic mothers than in large for gestational age infants of nondiabetic mothers.


CONCLUSIONS
Large for gestational age infants born from nondiabetic mothers showed delayed fall in pulmonary arterial pressure similar to those born from diabetic mothers but showed lower proportion of septal hypertrophy. Patent ductus arteriosus persisted for longer period of time in all large for gestational age infants than in normal infants, but its closure was significantly delayed in infants of diabetic mothers.
Vela-Huerta
M
M
Department of Neonatology, Hospital of Gynecology and Obstetrics, Leon, Mexico. mmavehu@yahoo.com.mx
Aguilera-López
A
A
Alarcón-Santos
S
S
Amador
N
N
Aldana-Valenzuela
C
C
Heredia
A
A
D000222:Adaptation, Physiological / Q000502:physiology*; D001724:Birth Weight; D049628:Body Size; D002312:Cardiomyopathy, Hypertrophic / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology*; D004374:Ductus Arteriosus, Patent / Q000453:epidemiology*; D015150:Echocardiography, Doppler; D018618:Echocardiography, Doppler, Color; D005260:Female; D006304:Health Status; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000098:blood supply*; D009035:Mothers / Q000706:statistics & numerical data*; D011247:Pregnancy; D011248:Pregnancy Complications; D011651:Pulmonary Artery / Q000502:physiology*