title: The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress.
abstract: Recently, it has been elucidated that cognitive dysfunction following cranial radiotherapy might be linked to the oxidative stress-induced impairment of hippocampal neurogenesis that is mediated by proliferating neural stem or progenitor cells. The novel free-radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) has been clinically used to reduce neuronal damage following ischemic stroke. Here, we demonstrate via in vitro studies that edaravone protects human neural stem cells (NSCs) from cell death and restores their differentiation ability after irradiation; however, the protective effect of edaravone is not observed in human brain tumor cells. Our study may shed some light on the beneficial effects of free-radical scavengers in impaired neurogenesis following cranial radiation therapy.
authors: Department of Biosciences, Teikyo University of Science and Technology, Uenohara, Yamanashi 409-0193, Japan.
authors: Jun
authors: J
authors: Ishii
authors: Atsushi
authors: A
authors: Natsume
authors: Toshihiko
authors: T
authors: Wakabayashi
authors: Hiroki
authors: H
authors: Takeuchi
authors: Hiroyuki
authors: H
authors: Hasegawa
authors: Seung U
authors: SU
authors: Kim
authors: Jun
authors: J
authors: Yoshida
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001932:Brain Neoplasms / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005910:Glioma / Q000473:pathology; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000378:metabolism / Q000473:pathology* / Q000528:radiation effects; D018384:Oxidative Stress; D011832:Radiation Injuries / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology* / Q000528:radiation effects
chemical_list: D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine