Interleukin-12, interleukin-23, and psoriasis: current prospects.
The clinical phenotype of psoriasis results from infiltration of T cells in the skin and elaboration of inflammatory cytokines. Interleukin (IL)-12 and, more recently, IL-23 have been implicated in the pathogenesis of psoriatic lesions. New therapies, including a monoclonal antibody against a subunit shared by IL-12 and IL-23, have been developed to treat psoriasis. Our purpose was to review the literature on IL-12 and IL-23 as a basis for understanding the use of anti-IL-12/IL-23 therapy for psoriasis. A review of English-language articles was performed using PubMed to identify articles pertaining to IL-12, IL-23, and psoriasis. IL-12 and IL-23 share a common subunit (p40) and have a distinct subunit (p35 and p19, respectively). Transgenic mice that overexpress IL-12 p40 develop inflammatory skin lesions. Both IL-12 knockout mice, which are deficient in IL-12, and human beings with a genetic IL-12 deficiency show increased susceptibility to intracellular pathogens and defective delayed-type hypersensitivity responses. These genetic deficiency states suggest the potential for adverse side effects from clinical administration of anti IL-12 p40 therapy. IL-12 p40 antibody was well tolerated in a phase I clinical trial with few adverse events and substantial improvements in psoriasis in most individuals. There was dose-dependent efficacy and substantial improvement in a larger cohort of patients in a phase II clinical trial. Larger and longer trials of anti IL-12/IL-23 therapies are needed to assess their clinical use and potential for infection and other adverse events.
Torti
Dorothea C
DC
Dartmouth Medical School, Lebanon, New Hampshire, USA.
Feldman
Steven R
SR
D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control; D002986:Clinical Trials as Topic; D003453:Cryptococcosis / Q000188:drug therapy; D006801:Humans; D018664:Interleukin-12 / Q000276:immunology / Q000502:physiology*; D053762:Interleukin-12 Subunit p40 / Q000172:deficiency / Q000276:immunology / Q000502:physiology*; D053759:Interleukin-23 / Q000276:immunology / Q000502:physiology*; D007896:Leishmaniasis / Q000517:prevention & control; D051379:Mice; D018345:Mice, Knockout; D011565:Psoriasis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D053707:Receptors, Interleukin-12 / Q000172:deficiency; D014124:Toxoplasmosis, Animal / Q000517:prevention & control; D014777:Virus Diseases / Q000517:prevention & control
D053762:Interleukin-12 Subunit p40; D053759:Interleukin-23; D053707:Receptors, Interleukin-12; D018664:Interleukin-12