Synthesis and characterization of thermosensitive PNIPAM microgels covered with superparamagnetic gamma-Fe2O3 nanoparticles.
In the present study we report a facile and reproducible method of preparing magnetic thermosensitive hybrid material based on P(NIPAM) microgels covered with gamma-Fe2O3 nanoparticles of 6-nm size. The iron oxide nanoparticles provided magnetic response to the microgels. In addition, the presence of the magnetic nanoparticles on the microgels altered their swelling behavior and shifted their volume phase transition temperature to higher values. In particular, for inorganic shells with 18% (w/w) of magnetic nanoparticles the volume phase transition of the microgels was shifted from 36 to 40 degrees C. In contrast, for shells consisting of 38% (w/w) magnetic nanoparticles the volume phase transition of the microgels was almost blocked, thus indicating that the microgel thermal response was strongly affected by the presence of the inorganic nanoparticles. The synthesized thermosensitive magnetic microgels are envisaged to be ideal for potential applications as thermosensitive targeted drug delivery systems.
Rubio-Retama
Jorge
J
Leibniz-Institut für Polymerforschung Dresden, Hohe Strasse 6, Dresden 01069, Germany. rubio@ipfdd.de
Zafeiropoulos
Nikolaos E
NE
Serafinelli
Caterina
C
Rojas-Reyna
Rosana
R
Voit
Brigitte
B
Cabarcos
E Lopez
EL
Stamm
Manfred
M
D000180:Acrylic Resins / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D005782:Gels; D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D013696:Temperature
D000180:Acrylic Resins; D005290:Ferric Compounds; D005782:Gels; C000499:ferric oxide; C052970:poly-N-isopropylacrylamide