title: Primary acinar cell carcinoma of the ampulla of Vater.
abstract: Acinar cell carcinoma of the pancreatobiliary system is a relatively rare malignant neoplasm arising usually in the pancreatic parenchyma. We experienced a 68-year-old woman who presented with obstructive jaundice due to an ampullary mass 1.0 cm in diameter, detected by abdominal computed tomography and endoscopic examination. The patient underwent a curative surgical operation, and histopathological examination revealed that the tumor was confined to the ampulla of Vater with no continuity to the pancreatic parenchyma. The tumor cells showed acinar or tubular arrangement with eosinophilic to basophilic granular cytoplasm, findings identical to those of acinar cell carcinoma of the pancreas. Immunohistochemically, the tumor cells were positive for lipase. From these findings, we concluded that the tumor was primary acinar cell carcinoma arising in the ampulla of Vater, probably originating from heterotopic pancreatic tissue. This is the first reported case of primary acinar cell carcinoma in the ampulla of Vater.
authors: Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.
authors: Hiroshi
authors: H
authors: Kawakami
authors: Masaki
authors: M
authors: Kuwatani
authors: Manabu
authors: M
authors: Onodera
authors: Satoshi
authors: S
authors: Hirano
authors: Satoshi
authors: S
authors: Kondo
authors: Yoshitsugu
authors: Y
authors: Nakanishi
authors: Tomoo
authors: T
authors: Itoh
authors: Masahiro
authors: M
authors: Asaka
mesh_terms: D014670:Ampulla of Vater; D001706:Biopsy; D018267:Carcinoma, Acinar Cell / Q000175:diagnosis* / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D019160:Endosonography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D016577:Pancreaticoduodenectomy / Q000379:methods; D014057:Tomography, X-Ray Computed
references: Arch Pathol Lab Med. 2001 Aug;125(8):1127-8
references: 11473479
references: Dig Surg. 2005;22(5):377-9
references: 16432300
references: Arch Pathol Lab Med. 1994 May;118(5):568-71
references: 8192567
references: Hum Pathol. 2004 Feb;35(2):263-5
references: 14991547
references: Gastrointest Endosc. 2001 Jan;53(1):121-3
references: 11154509
references: Am J Surg Pathol. 1992 Sep;16(9):815-37
references: 1384374
references: Arch Pathol Lab Med. 1999 Aug;123(8):707-11
references: 10420228
references: Am J Clin Oncol. 1997 Feb;20(1):101-7
references: 9020300
references: Hum Pathol. 2002 Apr;33(4):449-51
references: 12055683