Magnetic and fluorescent nanoparticles for multimodality imaging.
The development of nanoparticulate contrast agents is providing an increasing contribution to the field of diagnostic and molecular imaging. Such agents provide several advantages over traditional compounds. First, they may contain a high payload of the contrast-generating material, which greatly improves their detectability. Second, multiple properties may be easily integrated within one nanoparticle to allow its detection with several imaging techniques or to include therapeutic qualities. Finally, the surface of such nanoparticles may be modified to improve circulation half-lives or to attach targeting groups. Magnetic resonance imaging and optical techniques are highly complementary imaging methods. Combining these techniques would therefore have significant advantages and may be realized through the use of nanoparticulate contrast agents. This review gives a survey of the different types of fluorescent and magnetic nanoparticles that have been employed for both magnetic resonance and optical imaging studies.
Mulder
Willem J M
WJ
Mount Sinai School of Medicine, Imaging Science Laboratories, Department of Radiology, New York, NY 10029, USA. willem.mulder@mountsinai.org
Griffioen
Arjan W
AW
Strijkers
Gustav J
GJ
Cormode
David P
DP
Nicolay
Klaas
K
Fayad
Zahi A
ZA
D003287:Contrast Media / Q000737:chemistry*; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D008856:Microscopy, Fluorescence / Q000379:methods*; D015336:Molecular Probe Techniques; D053758:Nanoparticles / Q000648:ultrastructure
D003287:Contrast Media