title: The behaviour of selected yttrium containing bioactive glass microspheres in simulated body environments.
abstract: The study aims at the manufacture and investigation of biodegradable glass microspheres incorporated with yttrium potentially useful for radionuclide therapy of cancer. The glass microspheres in the SiO2-Na2O-P2O5-CaO-K2O-MgO system containing yttrium were prepared by conventional melting and flame spheroidization. The behaviour of the yttrium silicate glass microspheres was investigated under in vitro conditions using simulated body fluid (SBF) and Tris buffer solution (TBS), for different periods of time, according to half-life time of the Y-90. The local structure of the glasses and the effect of yttrium on the biodegradability process were evaluated by Fourier Transform Infrared (FT-IR) spectroscopy and Back Scattered Electron Imaging of Scanning Electron Microscopy (BEI-SEM) equipped with Energy Dispersive X-ray (EDX) analysis. UV-VIS spectrometry and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used for analyzing the release behaviour of silica and yttrium in the two used solutions. The results indicate that the addition of yttrium to a bioactive glass increases its structural stability which therefore, induced a different behaviour of the glasses in simulated body environments.
authors: Faculty of Physics, Babes-Bolyai University, M. Kogalniceanu 1, Cluj-Napoca 400084, Romania. dana.cacaina@utu.fi
authors: D
authors: D
authors: Cacaina
authors: H
authors: H
authors: Ylänen
authors: S
authors: S
authors: Simon
authors: M
authors: M
authors: Hupa
mesh_terms: D001826:Body Fluids / Q000502:physiology*; D002113:Calcification, Physiologic / Q000502:physiology; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology; D002516:Ceramics / Q000737:chemistry* / Q000378:metabolism; D011232:Chemical Precipitation; D008422:Materials Testing; D008863:Microspheres; D012822:Silicon Dioxide / Q000493:pharmacokinetics; D013057:Spectrum Analysis; D015019:Yttrium / Q000737:chemistry*
chemical_list: C022107:Bioglass; D002130:Calcium Phosphates; D015019:Yttrium; D012822:Silicon Dioxide; C020243:calcium phosphate
references: J Biomed Mater Res. 2001;58(6):720-6
references: 11745526
references: Biomaterials. 2001 Aug;22(16):2301-6
references: 11456070
references: J Mater Sci Mater Med. 2002 Dec;13(12):1221-5
references: 15348669
references: Curr Med Chem. 2002 Jan;9(1):73-82
references: 11860349
references: Biomaterials. 1997 Mar;18(6):453-8
references: 9111947
references: J Mater Sci Mater Med. 2006 Aug;17 (8):709-16
references: 16897163