title: Effects of amlodipine, captopril, and bezafibrate on oxidative milieu in rats with fatty liver.
abstract: Oxidative stress may initiate significant hepatocyte injury in subjects with fatty liver. We characterized changes in hepatic oxidative anti-oxidative parameters in rats given a fructose-enriched diet (FED) with and without medications to reduce blood pressure or plasma triglycerides. FED rats had an increase in malondialdehyde (MDA) concentration, a reduction in alpha-tocopherol concentration, a reduction in paraoxonase (PON) activity, an increase in glutathione peroxidase (GSH-Px), and glutathione reductase (GSSG-R) activity. Amlodipine increased PON and GSH-Px, but decreased GSSG-R activity and alpha-tocopherol concentration. Captopril decreased MDA concentration and the activity of both GSH-Px and GSSG-R, but increased alpha-tocopherol concentration and PON activity. Bezafibrate increased alpha-tocopherol concentration and PON activity, but decreased the activity of GSSG-R. Animals with fatty liver exhibit an increase in peroxidative stress but also a defect in anti-oxidative pathways. Drugs administered to treat hypertension and hypertriglyceridemia could lead to a variety of changes in the hepatic oxidative, anti-oxidative milieu.
authors: Department of Medicine, Hadassah-Hebrew University Medical Center, Mount Scopus Campus, Jerusalem 91240, Israel. zackerman@hadassah.org.il
authors: Zvi
authors: Z
authors: Ackerman
authors: Mor
authors: M
authors: Oron-Herman
authors: Talma
authors: T
authors: Rosenthal
authors: Orit
authors: O
authors: Pappo
authors: Gabriela
authors: G
authors: Link
authors: Ben-Ami
authors: BA
authors: Sela
authors: Maria
authors: M
authors: Grozovski
mesh_terms: D017311:Amlodipine / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001629:Bezafibrate / Q000494:pharmacology / Q000627:therapeutic use; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use; D005234:Fatty Liver / Q000150:complications / Q000188:drug therapy*; D005632:Fructose / Q000009:adverse effects*; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000188:drug therapy; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000959:Antihypertensive Agents; D000960:Hypolipidemic Agents; D017311:Amlodipine; D005632:Fructose; D002216:Captopril; D001629:Bezafibrate
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