Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys.
A strain of Plasmodium falciparum from Peru was adapted to splenectomized Aotus nancymaae and Aotus vociferans monkeys. The Peru 134/CDC strain of P. falciparum was shown to be resistant to treatment with chloroquine in monkeys and partially resistant to mefloquine and malarone. Genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this Peruvian strain of P. falciparum.
Collins
William E
WE
Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention/USPHS/DHHS, 4770 Buford Highway, Chamblee, GA 30341, USA. wec1@cdc.gov
Sullivan
Joann S
JS
Hall
Patrice
P
Ruebush
Trenton K
TK
Williams
Allison
A
Grady
Katharine K
KK
Bounngaseng
Amy
A
Nace
Douglas
D
Williams
Tyrone
T
Huber
Curtis
C
Galland
G Gale
GG
Barnwell
John W
JW
Sullivan
James J
JJ
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use; D016645:Aotidae; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use; D045303:Cytochromes b / Q000235:genetics; D016054:DNA, Protozoan / Q000737:chemistry / Q000235:genetics; D004094:Dihydropteroate Synthase / Q000235:genetics; D004195:Disease Models, Animal; D018432:Drug Resistance, Multiple / Q000235:genetics; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology*; D015767:Mefloquine / Q000494:pharmacology / Q000627:therapeutic use; D008992:Monkey Diseases / Q000188:drug therapy / Q000469:parasitology*; D018512:Parasitemia / Q000188:drug therapy / Q000469:parasitology; D010568:Peru; D010963:Plasmodium falciparum / Q000201:enzymology / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D017422:Sequence Analysis, DNA; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics
D000962:Antimalarials; D016054:DNA, Protozoan; D002738:Chloroquine; D045303:Cytochromes b; D013762:Tetrahydrofolate Dehydrogenase; D004094:Dihydropteroate Synthase; D015767:Mefloquine