Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in I M.
Previous work done by our laboratory has demonstrated a reduction of the post-burst afterhyperpolarization (AHP) and accommodation following trace eyeblink conditioning in rabbit CA1 pyramidal neurons. Our laboratory has also demonstrated a reduction in the AHP in rat CA1 pyramidal neurons following spatial learning. In the current study we have extended our findings in rabbits by showing a reduction in both the AHP and accommodation in F344 X BN rat CA1 pyramidal neurons following acquisition of trace eyeblink conditioning. A component current of the AHP, I(M), was evaluated with a specific blocker of this current, and showed no apparent contribution to the learning-related increase in neuronal excitability. Rather, a reduction in an isoproterenol-sensitive component of the AHP, presumably sI(AHP), was observed to underlie the learning-specific change.
Kuo
Amy G
AG
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. agkuo@umich.edu
Lee
Grace
G
McKay
Bridget M
BM
Disterhoft
John F
JF
D000200:Action Potentials / Q000187:drug effects*; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001143:Arousal / Q000187:drug effects*; D001767:Blinking / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D004576:Electromyography; D006624:Hippocampus / Q000187:drug effects; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D018408:Patch-Clamp Techniques; D024681:Potassium Channels, Calcium-Activated / Q000378:metabolism*; D017966:Pyramidal Cells / Q000187:drug effects*; D051381:Rats; D011916:Rats, Inbred F344
D000318:Adrenergic beta-Agonists; D024681:Potassium Channels, Calcium-Activated; D007545:Isoproterenol
J Neurophysiol. 1991 Apr;65(4):796-807
2051204
Hippocampus. 1997;7(3):271-85
9228525
J Neurosci. 1986 Feb;6(2):475-80
3456434
J Physiol. 1986 Mar;372:245-59
2425084
J Neurophysiol. 1990 Jan;63(1):72-81
2299387
J Neurophysiol. 2003 Oct;90(4):2171-9
12815013
J Neurophysiol. 2001 Jan;85(1):319-22
11152731
Nat Neurosci. 2005 Jan;8(1):51-60
15608631
Neurobiol Aging. 1996 Jul-Aug;17(4):619-29
8832637
Pflugers Arch. 1996 Mar;431(5):723-8
8596722
J Neurophysiol. 1996 Sep;76(3):1836-49
8890296
J Neurosci. 1996 Sep 1;16(17):5536-46
8757265
Neuroscience. 2006;137(1):113-23
16242849
Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4662-7
10200319
J Neurosci. 2000 Jan 15;20(2):783-90
10632607
J Neurosci. 1999 Mar 1;19(5):1814-23
10024365
Cell Mol Life Sci. 1999 Apr;55(4):534-48
10357224
Behav Neurosci. 1999 Oct;113(5):1100-5
10571493
Learn Mem. 2004 Jan-Feb;11(1):116-22
14747525
Prog Brain Res. 1990;83:161-87
2203097
J Physiol. 2000 Jan 15;522 Pt 2:231-46
10639100
J Pharmacol Exp Ther. 1998 Aug;286(2):709-17
9694925
Eur J Neurosci. 1998 Apr;10(4):1518-23
9749805
J Neurophysiol. 2001 Dec;86(6):2878-86
11731544
J Neurophysiol. 2006 Oct;96(4):1728-33
16823026
Science. 1984 Nov 30;226(4678):1037-45
6093258
Neuroscientist. 2002 Apr;8(2):122-31
11954557
Nature. 1983 Mar 31-Apr 6;302(5907):432-4
6300681
Behav Neurosci. 1997 Oct;111(5):1031-40
9383522
Science. 1998 Dec 4;282(5395):1890-3
9836639
J Neurophysiol. 1993 Jun;69(6):2129-36
7688802
Behav Neurosci. 2000 Dec;114(6):1109-18
11142643
Trends Neurosci. 1996 Apr;19(4):150-4
8658599
Neuron. 1993 Dec;11(6):1023-35
8274274
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2733-7
3458232
J Physiol. 1984 Sep;354:319-31
6434729
Ageing Res Rev. 2002 Apr;1(2):181-207
12039438