Noninvasive measurement of the cerebral blood flow response in human lateral geniculate nucleus with arterial spin labeling fMRI.
To date, functional magnetic resonance imaging (fMRI) studies of the lateral geniculate nucleus (LGN) have primarily focused on measures of the blood oxygenation level dependent (BOLD) signal. Arterial spin labeling (ASL) is an MRI method that can provide direct measures of functional cerebral blood flow (CBF) changes. Because CBF is a well-defined physiological quantity that contributes to BOLD contrast, CBF measures can be used to improve the quantitative interpretation of fMRI studies. However, due in part to the low intrinsic signal-to-noise ratio of the ASL method, measures of functional CBF changes in the LGN are challenging and have not previously been reported. In this study, we demonstrate the feasibility of using ASL fMRI to measure the CBF response of the LGN to visual stimulation on a 3 T MRI system. The use of background suppression and physiological noise reduction techniques allowed reliable detection of LGN activation in all five subjects studied. The measured percent CBF response during activation ranged from 40 to 100%, assuming no interaction between the left and right LGN.
Lu
Kun
K
Center for Functional MRI, University of California San Diego, La Jolla, California 92093-0677, USA. kunlu@ucsd.edu
Perthen
Joanna E
JE
Duncan
Robert O
RO
Zangwill
Linda M
LM
Liu
Thomas T
TT
D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D002560:Cerebrovascular Circulation; D005260:Female; D005829:Geniculate Bodies / Q000098:blood supply*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male
Magn Reson Med. 1995 May;33(5):636-47
7596267
Magn Reson Med. 2007 Nov;58(5):1020-7
17969096
J Neurosci. 1996 Jul 1;16(13):4207-21
8753882
Comput Biomed Res. 1996 Jun;29(3):162-73
8812068
J Neurosci. 1997 Apr 15;17(8):2859-68
9092607
Spat Vis. 1997;10(4):433-6
9176952
Magn Reson Med. 1999 Nov;42(5):849-63
10542343
Arch Ophthalmol. 2000 Mar;118(3):378-84
10721961
Magn Reson Med. 2000 Jul;44(1):92-100
10893526
Magn Reson Med. 2000 Jul;44(1):137-43
10893532
Magn Reson Med. 2001 Feb;45(2):202-5
11180426
J Neuroophthalmol. 2001 Mar;21(1):8-11
11315986
Ophthalmic Res. 2001 Sep-Oct;33(5):276-82
11586061
AJNR Am J Neuroradiol. 2001 Oct;22(9):1719-26
11673167
Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3216-22
11726625
Neuroimage. 2002 Mar;15(3):488-500
11848692
Nat Neurosci. 2002 Nov;5(11):1203-9
12379861
Magn Reson Med. 2003 May;49(5):796-802
12704760
Prog Retin Eye Res. 2003 Jul;22(4):465-81
12742392
Spat Vis. 1997;10(4):437-42
9176953
J Cereb Blood Flow Metab. 2003 Jul;23(7):829-37
12843786
Ophthalmologica. 2003 Sep-Oct;217(5):365-9
12913328
Neuroimage. 2003 Sep;20(1):591-600
14527620
Nat Rev Neurosci. 2003 Nov;4(11):863-72
14595398
J Neurophysiol. 2004 Jan;91(1):438-48
13679404
Neuroimage. 2004 Apr;21(4):1652-64
15050588
Magn Reson Med. 2004 Jul;52(1):131-40
15236376
J Neurosci. 2004 Oct 13;24(41):8975-85
15483116
Neuroimage. 2004;23 Suppl 1:S220-33
15501093
Proc Natl Acad Sci U S A. 1990 Dec;87(24):9868-72
2124706
Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):212-6
1729691
Magn Reson Med. 1992 Jan;23(1):37-45
1734182
Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5675-9
1608978
Neuroimage. 1995 Sep;2(3):173-81
9343600
Magn Reson Med. 1998 Jan;39(1):89-96
9438442
Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1834-9
9465103
Magn Reson Med. 1998 May;39(5):702-8
9581600
Magn Reson Med. 1998 Sep;40(3):383-96
9727941
Neuroreport. 1998 Nov 16;9(16):3669-74
9858377
Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2430-4
10051659
J Magn Reson Imaging. 1999 Apr;9(4):531-8
10232510
Jpn J Ophthalmol. 2004 Nov-Dec;48(6):558-64
15592780
Neuroimage. 2005 Jan 1;24(1):207-15
15588612
Ophthalmologica. 2005 Jan-Feb;219(1):11-5
15627821
Exp Eye Res. 2005 Jan;80(1):43-9
15652525
Magn Reson Med. 2005 Mar;53(3):735-8
15723412
Neuroimage. 2005 May 1;25(4):1100-11
15850728
Magn Reson Med. 2005 Aug;54(2):366-72
16032674
Magn Reson Med. 2005 Aug;54(2):491-8
16032686
Neuroimage. 2005 Aug 15;27(2):393-401
15921936
Neuroimage. 2006 Apr 15;30(3):726-34
16337135
Neuroimage. 2006 Jul 1;31(3):1104-15
16533609
Magn Reson Med. 1995 Sep;34(3):293-301
7500865