title: Distinguishing acute from chronic and resolved hepatitis C virus (HCV) infections by measurement of anti-HCV immunoglobulin G avidity index.
abstract: An assay to measure avidity index (AI) was developed to diagnose incident hepatitis C virus (HCV) infections. The assay demonstrated an AI value statistically significantly lower in primary HCV infections than in chronic infections. When the assay was applied to past resolved infections, the difference in AI values was not as significant as the difference between incident and chronic infections. Lower AI values obtained in past resolved infections may be directly related to lower levels of immunoglobulin G anti-HCV in past resolved infections than in either new infections or chronic infections.
authors: Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
authors: S
authors: S
authors: Klimashevskaya
authors: A
authors: A
authors: Obriadina
authors: T
authors: T
authors: Ulanova
authors: G
authors: G
authors: Bochkova
authors: A
authors: A
authors: Burkov
authors: A
authors: A
authors: Araujo
authors: Susan L
authors: SL
authors: Stramer
authors: Leslie H
authors: LH
authors: Tobler
authors: Michael P
authors: MP
authors: Busch
authors: Howard A
authors: HA
authors: Fields
mesh_terms: D000208:Acute Disease; D000915:Antibody Affinity; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D006526:Hepatitis C / Q000175:diagnosis*; D018937:Hepatitis C Antibodies / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000175:diagnosis*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D012367:RNA, Viral / Q000097:blood; D013997:Time Factors; D014508:Urea / Q000494:pharmacology
chemical_list: D018937:Hepatitis C Antibodies; D007074:Immunoglobulin G; D012367:RNA, Viral; D014508:Urea
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