A Potential Role for F-18 FDG PET/CT in Evaluation and Management of Fibrosing Mediastinitis.
Fibrosing mediastinitis is an uncommon benign disorder, and its pathogenesis and management remain unclear. Conventional imaging techniques (chest radiographs, CT, MRI) may suggest its diagnosis but are frequently nonspecific, and it frequently mimics a malignant process by presenting as a mediastinal mass without calcifications, encasing, and infiltrating adjacent mediastinal structures, and showing an overall aggressive behavior. The value of FDG PET imaging in this entity remains largely unknown with only a few case reports in the literature, and often, biopsy is necessary for definitive diagnosis. We report a case of biopsy proven fibrosing mediastinitis highlighting the utility of PET in the evaluation and management of the disease.
Takalkar
Amol M
AM
PET Imaging Center, Biomedical Research Foundation of Northwest Louisiana 71105, USA. atakalka@biomed.org
Bruno
Gabriel L
GL
Makanjoula
Akinloye J
AJ
El-Haddad
Ghassan
G
Lilien
David L
DL
Payne
D Keith
DK
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D005240:Feasibility Studies; D005260:Female; D005355:Fibrosis / Q000175:diagnosis / Q000188:drug therapy; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008480:Mediastinitis / Q000175:diagnosis* / Q000188:drug therapy*; D049268:Positron-Emission Tomography / Q000379:methods*; D011379:Prognosis; D019275:Radiopharmaceuticals; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18