Are Parkinson disease patients protected from some but not all cancers?
There is substantial evidence based on well designed epidemiologic studies for low cancer rates in patients with Parkinson disease (PD). This risk reduction cannot be attributed to the recognized low life-long incidence of smoking in patients with PD, as not only smoking-related cancers but also non-smoking-related ones are less common in PD. Whereas the risk for most cancers appears to be relatively low in patients with PD, breast cancer and melanomas occur more frequently in the PD population as compared with controls. The relationship between this peculiar pattern of cancer rates and PD might be related to the involvement of common genes in both diseases. Mutations in parkin gene, for example, have been reported in several types of cancer. Furthermore, genes involved in familial forms of PD appear to be abnormally expressed in cancers. Thus, parkin and PINK1 might be tumor suppressor genes, whereas DJ-1 is an oncogene. Cell survival signals may differ owing to mutated genes and represent two opposite extremes such as cell proliferation in cancer and cell death due to apoptosis in PD. Unraveling the link between PD and cancer may open a therapeutic window for both diseases.
Inzelberg
Rivka
R
Department of Neurology, Meir Hospital, Kfar Saba, Tchernikovsky Street, Israel. rivka.inzelberg@clalit.org.il
Jankovic
Joseph
J
D016923:Cell Death / Q000235:genetics; D002470:Cell Survival / Q000235:genetics; D015897:Comorbidity; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000502:physiology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology; D009857:Oncogenes / Q000235:genetics; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology; D012307:Risk Factors