Activity-dependent signaling pathways controlling muscle diversity and plasticity.
A variety of fiber types with different contractile and metabolic properties is present in mammalian skeletal muscle. The fiber-type profile is controlled by nerve activity via specific signaling pathways, whose identification may provide potential therapeutic targets for the prevention and treatment of metabolic and neuromuscular diseases.
Schiaffino
Stefano
S
Department of Biomedical Sciences, University of Padova, Padova, Italy. stefano.schiaffino@unipd.it
Sandri
Marco
M
Murgia
Marta
M
D000818:Animals; D019703:Calcineurin / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D006801:Humans; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D009136:Muscular Dystrophies / Q000503:physiopathology; D050778:NFATC Transcription Factors / Q000502:physiology; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*
D050778:NFATC Transcription Factors; D047492:Peroxisome Proliferator-Activated Receptors; D019703:Calcineurin