Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens.
Mutation of the HMG-CoA synthase encoding mupH gene in Pseudomonas fluorescens gives rise to a new metabolite formed from a truncated polyketide intermediate, providing in vivo evidence for the roles of mupH and cognate genes found in several "AT-less" and other bacterial PKS gene clusters responsible for the biosynthesis of diverse metabolites containing acetate/propionate derived side chains.
Wu
Ji'en
J
School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK.
Cooper
Sian M
SM
Cox
Russell J
RJ
Crosby
John
J
Crump
Matthew P
MP
Hothersall
Joanne
J
Simpson
Thomas J
TJ
Thomas
Christopher M
CM
Willis
Christine L
CL
D002384:Catalysis; D006904:Hydroxymethylglutaryl-CoA Synthase / Q000235:genetics / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D005810:Multigene Family / Q000235:genetics; D016712:Mupirocin / Q000096:biosynthesis* / Q000737:chemistry*; D009154:Mutation / Q000235:genetics; D048630:Polyketide Synthases / Q000378:metabolism; D011551:Pseudomonas fluorescens / Q000201:enzymology*
D048630:Polyketide Synthases; D016712:Mupirocin; D006904:Hydroxymethylglutaryl-CoA Synthase