Listeria as a vaccine vector.
The immunostimulatory characteristics and intracellular niche of Listeria monocytogenes make it uniquely suitable for use as a live bacterial vaccine vector. Preclinical results supporting this idea, and current strategies to induce beneficial cell-mediated immunity to both infectious diseases and cancer with this vector, are discussed in this review.
Bruhn
Kevin W
KW
Department of Medicine, Division of Dermatology, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502, USA. kbruhn@ucla.edu
Craft
Noah
N
Miller
Jeff F
JF
D000818:Animals; D001428:Bacterial Vaccines / Q000235:genetics* / Q000276:immunology; D019496:Cancer Vaccines / Q000235:genetics* / Q000276:immunology; D005822:Genetic Vectors / Q000235:genetics / Q000276:immunology; D006801:Humans; D008089:Listeria monocytogenes / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D014612:Vaccines / Q000235:genetics* / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology
D001428:Bacterial Vaccines; D019496:Cancer Vaccines; D014612:Vaccines; D014614:Vaccines, Synthetic