title: Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses.
abstract: Recently it has been shown by several laboratories that the influenza A virus nonstructural protein 1 (A/NS1) binds and activates phosphatidylinositol 3-kinase (PI3K). This function of the protein is likely to prevent premature apoptosis induction during viral propagation. Here we show that the B/NS1 protein completely lacks the capacity to induce PI3K signaling. Thus, PI3K activation is another unique function of A/NS1 that is different from the action of its influenza B virus counterpart.
authors: Institute of Molecular Virology (IMV), ZMBE, Westfaelische-Wilhelms-University, Von Esmarch-Strasse 56, D-48149 Muenster, Germany.
authors: Christina
authors: C
authors: Ehrhardt
authors: Thorsten
authors: T
authors: Wolff
authors: Stephan
authors: S
authors: Ludwig
mesh_terms: D000818:Animals; D017209:Apoptosis; D002522:Chlorocebus aethiops; D004285:Dogs; D004789:Enzyme Activation; D015967:Gene Expression Regulation, Viral; D009980:Influenza A virus / Q000378:metabolism*; D009981:Influenza B virus / Q000378:metabolism*; D008957:Models, Genetic; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction; D013045:Species Specificity; D014709:Vero Cells; D017361:Viral Nonstructural Proteins / Q000378:metabolism*
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D017361:Viral Nonstructural Proteins; C085820:INS1 protein, influenza virus
references: Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4309-14
references: 10725408
references: Apoptosis. 2007 Aug;12(8):1419-32
references: 17468837
references: Trends Mol Med. 2003 Feb;9(2):46-52
references: 12615037
references: J Virol. 2004 Feb;78(4):1865-72
references: 14747551
references: FEBS Lett. 2004 Jun 4;567(2-3):230-8
references: 15178328
references: Cell. 2004 Aug 6;118(3):274-6
references: 15294152
references: Curr Top Microbiol Immunol. 2004;283:249-80
references: 15298172
references: Virology. 1996 Sep 1;223(1):41-50
references: 8806538
references: EMBO J. 1996 Dec 2;15(23):6541-51
references: 8978681
references: Virology. 1998 Dec 20;252(2):324-30
references: 9878611
references: Nat Struct Mol Biol. 2004 Nov;11(11):1060-7
references: 15502848
references: Cell Microbiol. 2006 Mar;8(3):375-86
references: 16469051
references: Cell Microbiol. 2006 Aug;8(8):1336-48
references: 16882036
references: Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14194-9
references: 16963558
references: Oncogene. 2006 Oct 30;25(51):6844-67
references: 17072332
references: Science. 2006 Nov 10;314(5801):997-1001
references: 17038589
references: J Virol. 2006 Dec;80(23):11667-77
references: 16987984
references: J Gen Virol. 2007 Jan;88(Pt 1):13-8
references: 17170431
references: J Virol. 2007 Jan;81(2):514-24
references: 17079289
references: J Virol. 2007 Apr;81(7):3058-67
references: 17229704
references: Biochem Soc Trans. 2007 Apr;35(Pt 2):186-7
references: 17371234
references: Cell Microbiol. 2007 Apr;9(4):930-8
references: 17140406
references: Annu Rev Biochem. 2001;70:535-602
references: 11395417