Cytotoxic ent-abietane diterpenes from Gelonium aequoreum.
Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.
Lee
Chia-Lin
CL
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chang
Fang-Rong
FR
Hsieh
Pei-Wen
PW
Chiang
Michael-Y
MY
Wu
Chin-Chung
CC
Huang
Zih-You
ZY
Lan
Yu-Hsuan
YH
Chen
Mei
M
Lee
Kuo-Hsiung
KH
Yen
Hsin-Fu
HF
Hung
Wen-Chun
WC
Wu
Yang-Chang
YC
D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
D045784:Abietanes