Safety and efficiency of recombinant activated factor VII in postcardiotomy massive hemorrhage.
Postoperative massive hemorrhage is a difficult clinical situation after cardiac surgery. Recombinant activated factor VII (rf-VIIa) can be a useful adjunct to surgical hemostasis and blood product transfusion. Four cases of massive hemorrhage treated with rf-VIIa after complex cardiac surgery are reported. A review of the literature and possible guidelines for the use of rf-VIIa in cardiac surgery are provided.
Lamarche
Yoan
Y
Department of Surgery, Montreal Heart Institute and Université de Montréal, Montreal, QC, Canada. rc2910@aol.com
Demers
Philippe
P
Poirier
Nancy C
NC
Robitaille
Danielle
D
Cartier
Raymond
R
D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D003029:Coagulants; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use*; D012307:Risk Factors; D016896:Treatment Outcome
D003029:Coagulants; D011994:Recombinant Proteins; D015942:Factor VIIa
Br J Anaesth. 2005 Nov;95(5):596-602
16183679
J Intensive Care Med. 2006 Jan-Feb;21(1):54-9
16705777
JAMA. 2006 Jan 18;295(3):293-8
16418464
Blood Coagul Fibrinolysis. 2000 Apr;11 Suppl 1:S121-7
10850577
Transfusion. 2002 Jan;42(1):114-24
11896322
Anesth Analg. 2002 May;94(5):1369-70; author reply 1370-1
11973226
J Thorac Cardiovasc Surg. 2002 Oct;124(4):852-4
12324751
J Cardiothorac Vasc Anesth. 2002 Oct;16(5):615-6
12407617
Lancet. 2003 Jan 18;361(9353):201-5
12547542
Transfusion. 2005 Jan;45(1):26-34
15647015
Anesthesiology. 2005 Feb;102(2):269-75
15681939
N Engl J Med. 2005 Feb 24;352(8):777-85
15728810
Ann Thorac Surg. 2005 Apr;79(4):1303-6
15797067
Br J Anaesth. 2005 May;94(5):586-91
15734783
Pediatr Crit Care Med. 2005 May;6(3):348-51
15857537
An Pediatr (Barc). 2005 May;62(5):471-4
15871830
Anaesth Intensive Care. 2005 Apr;33(2):196-200
15960401
Ann Thorac Surg. 2005 Jul;80(1):3-5
15975330
Ann Thorac Surg. 2005 Jul;80(1):66-71
15975342
Pediatr Crit Care Med. 2005 Jul;6(4):473-6
15982438
Anesth Analg. 2005 Sep;101(3):924
16116021
Ann Fr Anesth Reanim. 2006 Jan;25(1):29-32
16256298
Ann Thorac Surg. 2006 Mar;81(3):875-9
16488687
Anesth Analg. 2006 May;102(5):1320-6
16632803
Thorac Cardiovasc Surg. 2005 Dec;53(6):389-90
16311981