title: Procalcitonin is elevated in the cerebrospinal fluid of patients with dementia and acute neuroinflammation.
abstract: Procalcitonin (PCT) is an established marker for severe systemic bacterial infection and sepsis in blood. Here we measured PCT by immunoassay in CSF and matched serum/plasma samples of controls and patients with different primary dementia disorders and acute neuroinflammation. PCT in CSF was significantly increased in patients with probable Alzheimer's disease, vascular dementia, dementia with Lewy bodies, frontotemporal dementia and acute neuroinflammation (encephalitis, meningitis) compared to non-demented controls. In contrast, PCT levels in matched plasma samples were normal in dementia groups, but elevated in meningitis/encephalitis. Our results indicate a central production of PCT and suggest PCT as a valuable marker candidate for the monitoring of dementia and acute neuroinflammation.
authors: Sphingotec GmbH, Tulpenweg 6, D-16556 Borgsdorf, Germany.
authors: Andrea
authors: A
authors: Ernst
authors: Nils G
authors: NG
authors: Morgenthaler
authors: Katharina
authors: K
authors: Buerger
authors: Richard
authors: R
authors: Dodel
authors: Carmen
authors: C
authors: Noelker
authors: Norbert
authors: N
authors: Sommer
authors: Markus
authors: M
authors: Schwarz
authors: Josef
authors: J
authors: Koehrle
authors: Andreas
authors: A
authors: Bergmann
authors: Harald
authors: H
authors: Hampel
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002116:Calcitonin / Q000097:blood / Q000134:cerebrospinal fluid*; D015740:Calcitonin Gene-Related Peptide; D016022:Case-Control Studies; D003704:Dementia / Q000097:blood / Q000134:cerebrospinal fluid*; D004660:Encephalitis / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020078:Neurogenic Inflammation / Q000097:blood / Q000134:cerebrospinal fluid*; D011498:Protein Precursors / Q000097:blood / Q000134:cerebrospinal fluid*; D012372:ROC Curve
chemical_list: C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide