Depression and suicide in epileptic victims: a population-based study of suicide victims during the years 1988-2002 in northern Finland.
Patients with epilepsy are known to have comorbid affective disorders and a higher risk for suicide compared with the general population. Epilepsy, depression, and suicidal behavior have been shown to have common pathogenic mechanisms in their etiology. We evaluated the association between epilepsy, suicidal behavior, and depression by using the comprehensive database of all suicides (n=1877) committed in northern Finland during the years 1988-2002 with information on all hospital-treated somatic and psychiatric disorders. Hospital-treated epilepsy occurred in 1.3% of the victims. Compared with other suicide victims, those with epilepsy were more often female, were older, and had significantly more often suffered from depression. Epilepsy was first diagnosed 8.8 (3.9-11.6) years before suicide, and depression, about 1 year after epilepsy diagnosis. Interictal depression among patients with chronic epilepsy is often classified as atypical or chronic depression, or it can mimic a dysthymic disorder. Therefore, diagnosis and treatment of depression among patients with epilepsy constitute a great challenge in clinical practice.
Mainio
Arja
A
Department of Psychiatry, Oulu University Hospital, FIN-90029 OYS, Oulu, Finland. arja.mainio@oulu.fi
Alamäki
Kaisa
K
Karvonen
Kaisa
K
Hakko
Helinä
H
Särkioja
Terttu
T
Räsänen
Pirkko
P
D000328:Adult; D018672:Community Health Planning; D003866:Depressive Disorder / Q000150:complications* / Q000453:epidemiology*; D004827:Epilepsy / Q000453:epidemiology*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D013405:Suicide / Q000706:statistics & numerical data*; D013406:Suicide, Attempted / Q000706:statistics & numerical data