[Long-term management of post acute coronary syndrome with oral antiplatelet therapy].
Cardiovascular disease is the primary cause of early death and morbidity in the industrialized world and is becoming a growing problem in many developing countries. Coagulation inhibitors play a major role in the management of the acute phase of ACS whether in association with reperfusion strategies or not. Currently, and in accordance with the results of major randomised studies, for medium and long-term management, the association of Clopidogrel and aspirin is the treatment of choice. However, despite the recognised benefits of this therapeutic strategy and above all the recommendations of learned societies, which have placed this bi-therapy in class I, according to national and international registries it is still underused. Moreover, all of these registries have confirmed, in the real world, the negative impact of not prescribing this antiplatelet therapy on morbidity and mortality after both ST and non-ST elevation acute coronary syndrome. which shows the difficulty of applying to everyday clinical practice the results of major randomised cohorts.
Lorgis
L
L
Service de cardiologie, CHU Bocage, boulevard Mal de Lattre de Tassigny, Dijon, France.
Zeller
M
M
Beer
J-C
JC
Buffet
P
P
L'Huillier
I
I
Nguyen
C
C
Schaad
F
F
Obbee
P
P
Lagrost
A-C
AC
Cottin
Y
Y
D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D000284:Administration, Oral; D001241:Aspirin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D000077144:Clopidogrel; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012042:Registries; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin