Association of interferon-gamma gene polymorphism (+874A) with arthritis manifestation in SLE.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which genetic factors strongly influence susceptibility. Cytokines such as the interferon-gamma (IFNG) gene play a key role in controlling the immunity and inflammation, and therefore their polymorphisms may affect these genes' expression levels among individuals. We investigated the frequency of IFNG gene intron (+874) polymorphism, previously reported to be associated with IFNG production, in SLE patients compared to a control group. This population-based case-control study includes 154 SLE patients and 154 healthy control subjects with similar ethnic backgrounds. The genotyping was determined by polymerase chain reaction sequence-specific primer method and using the Chi-squared test for analyzing the association between this single-nucleotide polymorphism and SLE. The allele frequencies of the IFNG (+874) gene polymorphism were not significantly different between SLE patients and control subjects (72.7 vs 77%). However, there was a significant association between A dominance model of inheritance with arthritis (odds ratio = 7.64, 95% confidence interval = 1.56-41.64, P = 0.006, P(c) = 0.03). The result suggested that the +874 intron polymorphism of IFNG can be used as the marker for SLE susceptibility with arthritis in the Thai population.
Tangwattanachuleeporn
Marut
M
Lupus Research Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Rama 4 road, Bangkok, 10330, Thailand.
Sodsai
Pimpayao
P
Avihingsanon
Yingyos
Y
Wongpiyabovorn
Jongkonnee
J
Wongchinsri
Jeerapat
J
Hirankarn
Nattiya
N
D000328:Adult; D001168:Arthritis / Q000150:complications* / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005786:Gene Expression Regulation; D005799:Genes, Dominant; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics* / Q000378:metabolism*; D007438:Introns; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013785:Thailand
D007371:Interferon-gamma
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