Novel generation of pH indicators for proton magnetic resonance spectroscopic imaging.
We describe the synthesis of 1,omega-di-1H-imidazoles 2 and 3, derived from l-threitol and d-mannitol, respectively, showing suitable magnetic and toxicological properties, as novel extracellular pH indicators for 1H spectroscopic imaging by magnetic resonance methods.
Soler-Padrós
Jordi
J
Laboratorio de Síntesis OrgAnica e Imagen Molecular por Resonancia Magnética, Instituto Universitario de Investigación, UNED, Paseo Senda del Rey 9, 28040 Madrid, Spain.
Pérez-Mayoral
Elena
E
Domínguez
Laura
L
López-Larrubia
Pilar
P
Soriano
Elena
E
Marco-Contelles
José Luis
JL
Cerdan
Sebastian
S
Ballesteros
Paloma
P
D000818:Animals; D001923:Brain Chemistry; D045744:Cell Line, Tumor; D005110:Extracellular Space / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009369:Neoplasms / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism
C523912:(3-((2,3,4,5-tetrahydroxyhexane-1,6-diyl)))di-1H-imidazole; C523911:(3-((2,3-dihydroxybutane-1,4-diyl)))-di-1H-imidazole; D007093:Imidazoles; D007202:Indicators and Reagents