title: CSF cortisol in Alzheimer's disease and mild cognitive impairment.
abstract: Hypercortisolaemia occurs in Alzheimer's disease (AD) and may be involved in the AD related neurodegenerative process. In order to determine whether brain structures are exposed to high cortisol concentrations early in AD, we measured cerebrospinal fluid (CSF) cortisol in 66 subjects with AD, 33 subjects with mild cognitive impairment (MCI) and 34 control subjects. CSF cortisol concentrations were higher in AD subjects compared to controls (p<0.001) and to MCI subjects (p=0.002). There was no significant increase of cortisol in MCI subjects compared with controls suggesting that the increase of CSF cortisol is not an early event in the course of AD.
authors: Department of Psychiatry, University of Bonn, Bonn, Germany. Julius.Popp@ukb.uni-bonn.de
authors: Julius
authors: J
authors: Popp
authors: Karsten
authors: K
authors: Schaper
authors: Heike
authors: H
authors: Kölsch
authors: Gabriela
authors: G
authors: Cvetanovska
authors: Fatima
authors: F
authors: Rommel
authors: Dietrich
authors: D
authors: Klingmüller
authors: Richard
authors: R
authors: Dodel
authors: Ullrich
authors: U
authors: Wüllner
authors: Frank
authors: F
authors: Jessen
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000523:psychology; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D006854:Hydrocortisone / Q000134:cerebrospinal fluid*; D009483:Neuropsychological Tests
chemical_list: D015415:Biomarkers; D006854:Hydrocortisone