title: Dendrazawaynes A and B, antifungal polyacetylenes from Dendranthema zawadskii (Asteraceae).
abstract: Two new C(14) polyacetylenes dendrazawayne A(7) and dendrazawayne B (9) together with known C(13) polyacetylenes (2, 3), C(14) polyacetylenes (1, 4, and 8) and polyacetylene amides (5 and 6) were isolated from the roots of Dendranthema zawadskii. The structures of 7 and 9 were elucidated based on spectroscopic methods including 2D-NMR, HR-TOF-MS, IR, and UV. Compounds 1, 2, 3, 5, and 6 showed moderate activity against tumor cell lines (human small lung cancer cell line A549, melanoma SK-Mel-2, and mouse melanoma B16F1) with IC(50) values in the range of 7.4 - 30 microg/mL. Compounds 7 and 9, including other polyacetylenes, showed strong activity against the fungus Trichophyton (MIC: 5 - 10 microg/mL).
authors: Department of Chemistry, Kongju National University, Kongju, Korea.
authors: Md Aziz Abdur
authors: MA
authors: Rahman
authors: Soon-Chang
authors: SC
authors: Cho
authors: Junsik
authors: J
authors: Song
authors: Hyeong-Tae
authors: HT
authors: Mun
authors: Surk-Sik
authors: SS
authors: Moon
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019659:Asteraceae; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D053279:Polyynes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014249:Trichophyton / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; C524031:dendrazawayne A; C524032:dendrazawayne B; D053279:Polyynes