title: Nutrition as a determinant of successful aging: description of the Quebec longitudinal study Nuage and results from cross-sectional pilot studies.
abstract: Optimal nutrition is essential for general well being, maintenance of physical and functional capacities and prevention of chronic disease in the elderly. The 5-year longitudinal study, NuAge, was designed to assess the pivotal role of nutrition on physical and cognitive status, functional autonomy and social functioning. A cohort of 1793 men and women, selected from three age groups (68-72, 73-77, 78-82) at recruitment, has been followed annually since 2003-2004. A plurimethodological approach, including basic, clinical, epidemiologic, and social research has been used. Data on various facets of nutritional status (diet, food habits, appetite, anthropometry and body composition), and functional (muscle strength, physical activity, physical and functional capacities and performance), medical (physical, mental and cognitive health, medication) and social data (network, support, participation) are collected by questionnaires or direct measurements. Blood, urine, and saliva samples are also collected and processed for genomic, transcriptomic, proteomic, and biochemical analyses and to study markers of endocrine, immune, and cognitive functions. Selected bio-psycho-social characteristics of the cohort, consumption of macronutrients, and biologic variables are presented, including the impact of intake of certain foods on total antioxidant status. Understanding the aging process as regulated by a modifiable factor such as nutrition should facilitate the development of targeted strategies for promoting successful aging.
authors: Laboratory of Neuroendocrinology of Aging, Centre hospitalier de l'Université de Montréal Research Center and Department of Medicine, Institut Universitaire de Gériatrie de Montréal, Canada. pierrette.gaudreau@umontreal.ca
authors: Pierrette
authors: P
authors: Gaudreau
authors: José A
authors: JA
authors: Morais
authors: Bryna
authors: B
authors: Shatenstein
authors: Katherine
authors: K
authors: Gray-Donald
authors: Abdel
authors: A
authors: Khalil
authors: Isabelle
authors: I
authors: Dionne
authors: Guylaine
authors: G
authors: Ferland
authors: Tamàs
authors: T
authors: Fülöp
authors: Danielle
authors: D
authors: Jacques
authors: Marie-Jeanne
authors: MJ
authors: Kergoat
authors: Daniel
authors: D
authors: Tessier
authors: Richard
authors: R
authors: Wagner
authors: Hélène
authors: H
authors: Payette
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000975:Antioxidants / Q000378:metabolism; D001835:Body Weight; D015331:Cohort Studies; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008136:Longevity; D008297:Male; D008875:Middle Aged; D052756:Nutritional Sciences; D016877:Oxidants / Q000378:metabolism; D010865:Pilot Projects; D012060:Rejuvenation
chemical_list: D000975:Antioxidants; D007328:Insulin; D016877:Oxidants; D005947:Glucose