title: Effects of nutritional and psychological status in gastrointestinal cancer patients on tolerance of treatment.
abstract: OBJECTIVE
  To assess the effects of poor nutritional and psychological status on tolerance of cancer treatment and the recovery of physical performance status in patients with gastrointestinal cancer.
  
  
  METHODS
  An epidemiological survey with respect to nutritional and psychological status in patients with gastrointestinal cancer was conducted among 182 operated patients in four provincial-level hospitals from December 2005 to June 2006. The food frequency survey method, state-trait anxiety inventory (STAI) and depression status inventory (DSI) were used to obtain information about the diet and psychological status in the patients. Nutritional status in the participants was reflected by serum albumin (Alb), hemoglobin (HB) and body mass index (BMI).
  
  
  RESULTS
  Alb, protein intake and anxiety were associated with the severity of side effects of treatment. The adjusted relative risk (RR) for Alb, protein intake and anxiety was 3.30 (95% CI: 1.08, 10.10, P = 0.03), 3.25 (95% CI: 1.06, 9.90, P = 0.04) and 1.48 (95% CI: 1.29, 1.70, P < 0.0001), respectively. Moreover, calorie intake, HB and depression were associated with the recovery of physical performance status in the patients. Adjusted relative risk was 2.12 (95% CI: 1.09, 4.03, P = 0.028), 2.05 (95% CI: 1.08, 3.88, P = 0.026) and 1.07 (95% CI: 1.02, 1.12, P = 0.007), respectively.
  
  
  CONCLUSIONS
  Both poor nutrition status and psychological status are independent risk factors for severe side effects of cancer treatment, and have impact on the recovery of physical performance status in patients after treatment.
authors: Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou 350004, Fujian Province, China. tianjun@mail.fjmu.edu.cn
authors: Jun
authors: J
authors: Tian
authors: Zhen-Chun
authors: ZC
authors: Chen
authors: Li-Fang
authors: LF
authors: Hang
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015992:Body Mass Index; D003131:Combined Modality Therapy / Q000009:adverse effects; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy*; D006306:Health Surveys; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status / Q000502:physiology*; D011788:Quality of Life; D011836:Radiation Tolerance / Q000502:physiology*; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism; D013315:Stress, Psychological / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D006454:Hemoglobins; D012709:Serum Albumin
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