Viral-associated trichodysplasia in a patient with lymphoma: a case report and review.
Viral-associated trichodysplasia is a recently described entity associated with immunosuppression. We describe a 68-year-old man with a history of treated lymphoma who developed numerous, disfiguring, papular and spiny lesions involving most of the central face. Both facial and body alopecia was noted. Histopathologic findings of a facial papule showed dramatic alterations of the hair bulbs, including bulbar distention, lack of hair shaft formation and a marked expansion of inner root sheath type epithelium. These findings were identical to those of previously described cases, so electron microscopy was performed. Numerous intranuclear virus particles were identified. Shortly after the diagnosis of trichodysplasia was made, the patient was found to have a relapse of his lymphoma, which may represent the source of his immunosuppression. Based on his skin biopsy findings, successful antiviral therapy was initiated. This case and a review of previously reported cases are discussed in this study.
Osswald
Sandra S
SS
Department of Dermatology, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA. ssosswald@aol.com
Kulick
Kevin B
KB
Tomaszewski
Maria-Magdalena
MM
Sperling
Leonard C
LC
D000287:Administration, Topical; D000368:Aged; D000505:Alopecia / Q000209:etiology / Q000473:pathology; D000998:Antiviral Agents / Q000627:therapeutic use; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000473:pathology / Q000821:virology*; D006201:Hair Diseases / Q000473:pathology / Q000821:virology*; D018859:Hair Follicle / Q000648:ultrastructure / Q000821:virology*; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D045586:Intranuclear Inclusion Bodies / Q000648:ultrastructure; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D063065:Organophosphonates / Q000627:therapeutic use; D011120:Polyomavirus / Q000648:ultrastructure; D016896:Treatment Outcome
D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir