The infrequent simultaneous genetic alterations in glioblastoma multiforme (LOH 10, 17, 19q, TP53 mutation and EGFR amplification) with short clinical course.
We described the case of an unusual, complex genetic alteration in 57 year-old male patient with glioblastoma multiforme (GBM) with short survival (6 and half months). Alterations consisted of p53 mutation, LOH 10, LOH 17, LOH 19q and EGFR amplification. LOH1p, LOH 9 and LOH 13 were negative. Immunohistochemical study did not correlate with molecular results. The overexpression of TP53 protein and RB protein was detected only in small percentage of cells and interestingly the overexpression of EGFR was present only focally. Immnunostainings for PTEN, P16, PI3-K were negative. Additionally, we observed an overexpression of IGFB2 protein. This case indicates the accumulation of molecular changes in glioblastoma multiforme in patient with short survival.
Jesionek-Kupnicka
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Department of Pathology, Medical University, Lódź. kupidor@poczta.onet.pl
Kulczycka
D
D
Rieske
P
P
Szybka
M
M
Jabłońska
J
J
Potemski
P
P
Kolasa
P
P
Liberski
P P
PP
Kordek
R
R
D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D002879:Chromosomes, Human, Pair 10; D002886:Chromosomes, Human, Pair 17; D002888:Chromosomes, Human, Pair 19; D003131:Combined Modality Therapy; D066246:ErbB Receptors / Q000235:genetics*; D017809:Fatal Outcome; D005784:Gene Amplification; D005909:Glioblastoma / Q000737:chemistry / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007124:Immunoenzyme Techniques; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020125:Mutation, Missense; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53; C512478:EGFR protein, human; D066246:ErbB Receptors