Family history of diabetes mellitus determines insulin sensitivity and beta cell function in polycystic ovary syndrome.
To examine the impact of family history of diabetes mellitus 2 (DM 2) on insulin sensitivity and secretion in lean women with polycystic ovary syndrome (PCOS). Thirteen healthy women (C), 14 PCOS without family history of DM 2 (FH-) and 8 PCOS with family history of DM 2 (FH+) were examined using euglycemic hyperinsulinemic clamp and an arginine secretion test (insulin and glucagon at fasting glycemia (AIR(FG) and AGR(FG)) and at hyperglycemia (AIR(14) and AGR(14)). FH+ women were more insulin resistant than FH- with lower insulin sensitivity index corrected per lean body mass (p 0.05). They had significantly higher triglycerides (p 0.05) and lower HDL-cholesterol (p 0.05) than C or FH- women. Concerning insulin secretion, AIR(FG) was increased in FH+ women comparing FH- women (p 0.05). Disposition indices derived from AIR(FG) or AIR(14) and insulin sensitivity index did not differ between FH+ or FH-. Thus, women with PCOS with the concomitant family history of DM 2 have lower insulin sensitivity than healthy control women. Insulin resistance observed in these women with PCOS is compensated by increased insulin secretion.
Vrbíková
J
J
Institute of Endocrinology, Prague, Czech Republic. jvrbikova@endo.cz
Grimmichová
T
T
Dvořáková
K
K
Hill
M
M
Stanická
S
S
Vondra
K
K
D000328:Adult; D000886:Anthropometry; D001120:Arginine / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000235:genetics* / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D050416:Glucagon-Secreting Cells / Q000502:physiology; D015309:Glucose Clamp Technique; D006706:Homeostasis; D006728:Hormones / Q000097:blood; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D050417:Insulin-Secreting Cells / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000235:genetics* / Q000503:physiopathology*
D001786:Blood Glucose; D006728:Hormones; D001120:Arginine