title: ICP and CPP: excellent predictors of long term outcome in severely brain injured children.
abstract: OBJECTIVE
  To determine the predictive powers of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) amongst severely brain injured children.
  
  
  METHODS
  ICP and CPP were recorded from thirty-five severely brain injured children who were prospectively recruited after admission to paediatric intensive care. Twenty-five suffered traumatic brain injury (TBI) and ten suffered non-TBI. Peak ICP and minimum CPP recorded for each patient during their admission were related to 5 year Glasgow Outcome Scale outcome. Receiver operator characteristic curves determined that the optimum threshold for unfavourable outcome prediction was >or=40 mmHg for ICP and <or=49 mmHg for CPP. At these thresholds the sensitivity/specificity pairs for the prediction of unfavourable outcome were 33.3/100% and 55.6/100% for ICP and CPP, respectively, amongst patients suffering TBI and were 46.2/100% and 66.2/100% for ICP and CPP, respectively, amongst all patients.
  
  
  CONCLUSIONS
  ICP and CPP are accurate predictors of unfavourable outcome.
authors: Paediatric Intensive Care Unit, Royal Children's Hospital, Flemington Rd, Parkville, Melbourne, Victoria, 3052, Australia. icu.tech@rch.org.au
authors: B G
authors: BG
authors: Carter
authors: W
authors: W
authors: Butt
authors: A
authors: A
authors: Taylor
mesh_terms: D000293:Adolescent; D001930:Brain Injuries / Q000401:mortality / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D023261:Glasgow Outcome Scale; D006801:Humans; D007223:Infant; D007427:Intracranial Pressure / Q000502:physiology*; D011379:Prognosis; D012372:ROC Curve; D012680:Sensitivity and Specificity
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