title: Prognostic role of the extent of peritumoral vascular invasion in operable breast cancer.
abstract: BACKGROUND
  The clinical relevance of the degree of peritumoral vascular invasion (PVI) in patients with no or limited involvement of the axillary nodes is unknown.
  
  
  METHODS
  2606 consecutive patients with pT1-3, pN0 (1586)-1a (1020) and M0, operated and counseled for medical therapy from 1/2000 to 12/2002, were prospectively classified according to the degree of PVI: absent (2017, 77.4%), focal (368, 14.1%), moderate (51, 2.0%) and extensive (170, 6.5%).
  
  
  RESULTS
  Patients with extensive PVI were more likely to be younger, to have larger tumors, high tumor grade, axillary-positive nodes, high Ki-67 expression and HER2/neu over-expression compared with patients having less PVI (P for trend, <0.0001). In patients with node-negative disease a statistically significant difference in disease-free survival (DFS), risk of distant metastases and overall survival (OS) was observed at the multivariate analysis for extensive PVI versus no PVI (hazard ratios: 2.11, 95% CI, 1.02 to 4.34, P = 0.04 for DFS; 4.51, 95% CI, 1.96 to 10.4, P< 0.001 for distant metastases; 3.55, 95% CI, 1.24 to 10.1, P = 0.02 for OS).
  
  
  CONCLUSIONS
  The extent of vascular invasion should be considered in the therapeutic algorithm in order to properly select targeted adjuvant treatment.
authors: Research Unit in Medical Senology at the Department of Medicine, Istituto Europeo di Oncologia, Milan, Italy. marco.colleoni@ieo.it
authors: M
authors: M
authors: Colleoni
authors: N
authors: N
authors: Rotmensz
authors: P
authors: P
authors: Maisonneuve
authors: A
authors: A
authors: Sonzogni
authors: G
authors: G
authors: Pruneri
authors: C
authors: C
authors: Casadio
authors: A
authors: A
authors: Luini
authors: P
authors: P
authors: Veronesi
authors: M
authors: M
authors: Intra
authors: V
authors: V
authors: Galimberti
authors: R
authors: R
authors: Torrisi
authors: S
authors: S
authors: Andrighetto
authors: R
authors: R
authors: Ghisini
authors: A
authors: A
authors: Goldhirsch
authors: G
authors: G
authors: Viale
mesh_terms: D000328:Adult; D000368:Aged; D001808:Blood Vessels / Q000473:pathology*; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011379:Prognosis; D011446:Prospective Studies