title: Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus.
abstract: Callophycoic acids A-H (1-8) and callophycols A and B (9 and 10) were isolated from extracts of the Fijian red alga Callophycus serratus, and identified by NMR, X-ray, and mass spectral analyses. These natural products represent four novel carbon skeletons, providing the first examples of diterpene-benzoic acids and diterpene-phenols in macroalgae. Compounds 1-10 exhibited antibacterial, antimalarial, and anticancer activity, although they are less bioactive than diterpene-benzoate macrolides previously isolated from this red alga.
authors: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
authors: Amy L
authors: AL
authors: Lane
authors: Elizabeth P
authors: EP
authors: Stout
authors: Mark E
authors: ME
authors: Hay
authors: Anne C
authors: AC
authors: Prusak
authors: Kenneth
authors: K
authors: Hardcastle
authors: Craig R
authors: CR
authors: Fairchild
authors: Scott G
authors: SG
authors: Franzblau
authors: Karine
authors: K
authors: Le Roch
authors: Jacques
authors: J
authors: Prudhomme
authors: William
authors: W
authors: Aalbersberg
authors: Julia
authors: J
authors: Kubanek
mesh_terms: D000818:Animals; D001565:Benzoates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*
chemical_list: D001565:Benzoates; D004224:Diterpenes; D010636:Phenols
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