Superiority of transplantation versus resection for the treatment of small hepatocellular carcinoma.
The best therapy for hepatocellular carcinoma (HCC) is still debated. Hepatic resection (HR) is the treatment of choice for single HCC in Child A patients, whereas liver transplantation (OLT) is usually reserved for Child B and C patients with multiple nodules. The aim of this study was to compare HR and OLT for HCC within the Milan criteria on an intention-to-treat basis. Forty-eight patients were treated by OLT and 38 by HR. Three- and 5-year patient survival rates were significantly higher (P = .0057) in the OLT group (79% and 74%) than after HR (61% and 26%). The 3- and 5-year disease-free survival rate was better (P = .0005) for OLT (74% and 74%) versus HR (41% and 11%). The probability of HCC recurrences after resection was greater (P = .0002) than after transplantation, achieving 31% and 76% for HR and 2% and 2% for OLT at 3 and 5 years after surgery. The median waiting list time was 118 days; two patients dropped out for HCC progression. We concluded that OLT is superior to HR for small HCC in cirrhotic patients assuming that OLT can be performed within 6 to 10 months after listing to reduce dropouts due to tumor progression.
Baccarani
U
U
Department of Surgery and Transplantation, University Hospital of Udine, Udine, Italy. umberto.baccarani@uniud.it
Benzoni
E
E
Adani
G L
GL
Avellini
C
C
Lorenzin
D
D
Sainz-Barriga
M
M
Bresadola
V
V
Uzzau
A
A
Risaliti
A
A
Beltrami
C A
CA
Bresadola
F
F
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000601:surgery; D006526:Hepatitis C / Q000150:complications / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D013514:Surgical Procedures, Operative; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome