title: Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis.
abstract: OBJECTIVE
  To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis and the pathogenesis of silicosis.
  
  
  METHODS
  Thirty healthy volunteers, 30 silica-exposed workers, and 30 workers with suspected silicosis and phase I silicosis were included. Serum CC16 and SP-D concentrations were determined using enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum CC16 concentrations decreased in silica-exposed workers when compared with in controls, but serum SP-D levels increased, and this trend was obvious in phase 0 and I groups. Discriminant analysis showed that the accuracies of classifying group membership into control, phase 0, phase 0, and phase I were 86.7%, 46.7%, 66.7%, and 70%, respectively, and the total classification accuracy rate was 67.5%.
  
  
  CONCLUSIONS
  Serum CC16 and SP-D may be useful biomarkers for early diagnosis, and serum SP-D concentration may associate with the pathogenesis of silicosis.
authors: Proteomics Laboratory, Medical College of Chinese People's Armed Police Force, Tianjin, China.
authors: Shi-Xin
authors: SX
authors: Wang
authors: Ping
authors: P
authors: Liu
authors: Mao-Ti
authors: MT
authors: Wei
authors: Lei
authors: L
authors: Chen
authors: Yang
authors: Y
authors: Guo
authors: Ran-Yang
authors: RY
authors: Wang
authors: Zhi-Guang
authors: ZG
authors: Tu
authors: Xian-Cai
authors: XC
authors: Liang
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D042241:Early Diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008906:Mining; D016273:Occupational Exposure / Q000009:adverse effects*; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood* / Q000502:physiology; D012822:Silicon Dioxide / Q000009:adverse effects*; D012829:Silicosis / Q000175:diagnosis* / Q000503:physiopathology; D014598:Uteroglobin / Q000097:blood* / Q000502:physiology
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D037663:Pulmonary Surfactant-Associated Protein D; C556389:SCGB1A1 protein, human; D012822:Silicon Dioxide; D014598:Uteroglobin