Veno-occlusive disease of the liver after lung transplantation.
Veno-occlusive disease (VOD) of the liver is mainly described after chemo-irradiation conditioning regimens during haematopoietic stem cell transplantation (SCT) and has been sporadically reported after kidney and liver transplantation. In the latter cases, it is commonly attributed to azathioprine and/or tacrolimus. One case of tacrolimus-induced hepatic VOD developing after lung transplantation (LT) has been recently reported. Here we describe another case of VOD occurring after LT, but in which the causative role was played by azathioprine.
de Fontbrune
F S
FS
Service de Pneumologie B et Transplantation Pulmonaire, Hôpital Bichat, Paris, France.
Mal
H
H
Dauriat
G
G
Brugière
O
O
Biondi
G
G
Taillé
C
C
Valla
D
D
Castier
Y
Y
Fournier
M
M
D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000188:drug therapy* / Q000473:pathology; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged
D007166:Immunosuppressive Agents; D001379:Azathioprine