MN1, a novel player in human AML.
The transcriptional coactivator MN1 has been identified as a gene overexpressed in certain types of human acute myeloid leukemia. Upregulation is invariantly associated with inv(16) AML but is also found in other AML subtypes. Overexpression of this gene is also associated with a worse prognosis and a shorter survival in AML patients with a normal karyotype. In this short review, I will discuss the role of MN1 in myeloid leukemia.
Grosveld
Gerard C
GC
Department of Genetics and Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, TN, USA. Gerard.grosveld@stjude.org
D000818:Animals; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D015534:Trans-Activators; D014178:Translocation, Genetic; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
C506524:MN1 protein, human; D015534:Trans-Activators; D025521:Tumor Suppressor Proteins
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