title: Anti-CD19 and anti-CD22 monoclonal antibodies increase the effectiveness of chemotherapy in Pre-B acute lymphoblastic leukemia cell lines.
abstract: The monoclonal antibodies (MAbs) HD37 and RFB4 bind to receptors on precursor B acute lymphoblastic leukemia (ALL) cells. These MAbs were tested alone and in combination with chemotherapy for their anti-leukemic activity. HD37 and not RFB4 increased the in vitro cytotoxicity of daunorubicin (DNR) and vincristine (VCR) in three Pre-B ALL cell lines. HD37 alone induced apoptosis in 30% of the cells versus 2% for RFB4. The treatment of SCID/ALL mice with either chemotherapy agent minimally prolonged their mean survival time (MST) versus controls but HD37 or RFB4 plus VCR significantly extended the MST. Forty percent of the mice treated with HD37 plus VCR survived. In conclusion, chemotherapy was made more effective when combined with HD37, and less so with RFB4.
authors: Department of Microbiology and Immunology, Temple University Medical School, Philadelphia, PA 19140, USA.
authors: C
authors: C
authors: Stanciu-Herrera
authors: C
authors: C
authors: Morgan
authors: L
authors: L
authors: Herrera
mesh_terms: D000208:Acute Disease; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D018941:Antigens, CD19 / Q000276:immunology*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D003630:Daunorubicin / Q000627:therapeutic use; D004357:Drug Synergism; D006801:Humans; D008297:Male; D051379:Mice; D016513:Mice, SCID; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D051918:Sialic Acid Binding Ig-like Lectin 2 / Q000276:immunology*; D015996:Survival Rate; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000903:Antibiotics, Antineoplastic; D000911:Antibodies, Monoclonal; D018941:Antigens, CD19; D000972:Antineoplastic Agents, Phytogenic; D051918:Sialic Acid Binding Ig-like Lectin 2; D014750:Vincristine; D003630:Daunorubicin
references: Arch Pathol Lab Med. 2003 Jan;127(1):42-8
references: 12521365
references: Am J Clin Pathol. 2002 Mar;117(3):380-9
references: 11888077
references: J Clin Oncol. 2003 Jul 15;21(14):2787-99
references: 12860957
references: Anticancer Drugs. 2003 Oct;14(9):669-82
references: 14551500
references: Cytometry B Clin Cytom. 2003 Nov;56(1):30-42
references: 14582135
references: Clin Cancer Res. 2004 Feb 15;10(4):1274-81
references: 14977825
references: Exp Cell Res. 2004 Aug 15;298(2):560-73
references: 15265702
references: J Immunol. 1987 May 1;138(9):2793-9
references: 2437199
references: Leuk Res. 1988;12(2):135-41
references: 3282129
references: Blood. 1988 Jul;72(1):299-307
references: 3291983
references: Cancer Res. 1989 Sep 1;49(17):4906-12
references: 2667754
references: J Immunol. 1991 Dec 1;147(11):3663-71
references: 1719083
references: Crit Rev Oncol Hematol. 1991 Dec;11(4):267-97
references: 1777090
references: Blood. 1992 Nov 1;80(9):2315-20
references: 1384801
references: Blood. 1993 Nov 1;82(9):2624-33
references: 8219217
references: Blood. 1994 Mar 1;83(5):1329-36
references: 7509655
references: Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4048-52
references: 7513431
references: Curr Opin Oncol. 1994 Jan;6(1):14-22
references: 8204688
references: J Immunol. 1995 Apr 1;154(7):3096-104
references: 7534787
references: Blood. 1995 Jun 15;85(12):3457-65
references: 7780133
references: Leuk Lymphoma. 1995 Aug;18(5-6):385-97
references: 8528044
references: Curr Biol. 1997 Feb 1;7(2):133-43
references: 9016707
references: Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7509-14
references: 9207122
references: Leuk Res. 1998 Jul;22(7):567-79
references: 9680106
references: J Immunol. 1998 Sep 15;161(6):3176-85
references: 9743386
references: Exp Hematol. 2005 Feb;33(2):199-211
references: 15676214
references: J Clin Oncol. 2005 Feb 1;23(4):694-704
references: 15681517
references: J Clin Oncol. 2005 Jun 1;23(16):3676-85
references: 15738535
references: Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15178-83
references: 16217038
references: Leukemia. 2003 Feb;17(2):334-8
references: 12592332
references: Clin Cancer Res. 1999 Dec;5(12):3920-7
references: 10632321
references: Clin Cancer Res. 2000 Apr;6(4):1302-13
references: 10778955
references: Immunity. 2000 Jul;13(1):47-57
references: 10933394
references: Br J Haematol. 2001 Sep;114(4):800-9
references: 11564066
references: J Biol Chem. 2001 Nov 23;276(47):44315-22
references: 11551923