title: Lead exposure induces pycnosis and enucleation of peripheral erythrocytes in the domestic fowl.
abstract: Lead (Pb) shot were administered orally to young chickens to determine the effects on red blood cells (RBCs). The concentrations of Pb in the blood of young chickens rose rapidly after Pb administration and were maintained at high levels for several days. The number of RBCs with pycnotic nuclei, reticulocytes and enucleated RBCs increased concurrently. Pycnotic nuclei were surrounded by enlarged nucleolemmal cisternae, which sometimes opened to the extracellular space. Gel electrophoresis showed that the presence of pycnotic nuclei was not associated with DNA fragmentation typical of apoptosis. It was concluded that exposure to lead shot changes nuclear morphology in the peripheral blood of domestic fowl.
authors: Department of Toxicology, School of Veterinary Medicine, Rakuno Gakuen University, Bunkyodai-Midorimachi, Ebetsu 069-8501, Japan.
authors: Takeo
authors: T
authors: Hiraga
authors: Kei
authors: K
authors: Ohyama
authors: Ayano
authors: A
authors: Hashigaya
authors: Tomoya
authors: T
authors: Ishikawa
authors: Wakana
authors: W
authors: Muramoto
authors: Hiroshi
authors: H
authors: Kitagawa
authors: Naoharu
authors: N
authors: Mizuno
authors: Hiroki
authors: H
authors: Teraoka
mesh_terms: D000818:Animals; D002645:Chickens; D004912:Erythrocytes / Q000187:drug effects*; D007854:Lead / Q000633:toxicity*; D007855:Lead Poisoning / Q000097:blood / Q000662:veterinary*; D008297:Male; D011201:Poultry Diseases / Q000097:blood*
chemical_list: D007854:Lead