[Synthesis and bioactivies of salicylic acid-g-chitosan derivatives].
To prepare the derivatives of salicylic acid-g-chitosan and study their synergistic and complementary actions, the synergism of anti-inflammatory action of the derivatives was investigated with the experiments of xylene-induces mice ear edema, the analgesic activities by the tartaric emetic-induced mice twist test and the hot-plate test, and the complementary effects between salicylic acid and chitosan through morphological changes of stomach mucous membrane of rat, separately. The anti-inflammatory activities of salicylic acid-g-chitosan derivatives for anti-inflammatory activities were more potent than that of salicylic acid and chitosan and dexamethasone cream in external use, and more potent than that of aspirin orally. However, immediate analgesic activity of the derivatives was lower than that of aspirin and persistent activity was similar as that of aspirin. And the stomach mucous membrane morphology change of the derivatives was much milder than that of aspirin. The salicylic acid grafted chitosan derivatives showed synergistic and complementary effect on the anti-inflammatory and analgesic activities and so on.
Wu
Xue-Fen
XF
Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China. wxf568@163.com
Li
Wei
W
Wang
Lei
L
Hu
Jian-Mei
JM
Li
Gui-Lan
GL
D000700:Analgesics / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology; D048271:Chitosan / Q000009:adverse effects / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004357:Drug Synergism; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D008297:Male; D051379:Mice; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012459:Salicylates / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology*
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D012459:Salicylates; D048271:Chitosan