Transcriptional networking cap-tures the 7SK RNA 5'-gamma-methyltransferase.
In a recent issue of Molecular Cell, Jeronimo et al. (2007) identify BCDIN3, a Cdk9-associated protein, as the enzyme that forms the distinctive gamma-methylphosphate cap structure of 7SK, a noncoding RNA that regulates Cdk9 activity.
Shuman
Stewart
S
Molecular Biology Program, Sloan-Kettering Institute, New York, NY 10021, USA. s-shuman@ski.mskcc.org
D000818:Animals; D053263:Gene Regulatory Networks / Q000235:genetics*; D006151:Guanosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008780:Methyltransferases / Q000378:metabolism*; D051379:Mice; D012315:RNA Caps / Q000235:genetics / Q000378:metabolism*; D012342:RNA, Small Nuclear / Q000378:metabolism*
D012315:RNA Caps; D012342:RNA, Small Nuclear; D006151:Guanosine; C016578:7-methylguanosine; D008780:Methyltransferases