Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children.
OBJECTIVE
To investigate the association of plasma fatty acids with the -866 G/A polymorphism of uncoupling protein 2 (UCP2) in obese children.


METHODS
Fatty acid composition of plasma phospholipids and sterol esters were investigated in 80 obese children.


RESULTS
Values of dihomo-gamma-linolenic acid (C20:3n-6) were significantly lower in children with the -866 A/A (n = 12) than in those with the -866 G/A (n = 34) or -866 G/G (n = 34) genotype in plasma phospholipids (3.01 [0.42] vs. 3.56 [1.02] vs. 3.53 [0.84], % weight/weight, median [interquartile range], p < 0.05), and were significantly lower in children with the -866 A/A genotype than in the other two groups in plasma sterol esters (0.73 [0.22] vs. 0.92 [0.23] vs. 0.94 [0.25], p < 0.05). Phospholipid C20:3n-6 and arachidonic acid (C20:4n-6) values showed only in children with the -866 G/G and -866 G/A genotypes significant positive correlations with plasma insulin concentrations.


CONCLUSIONS
Significantly lower values of C20:3n-6 can be detected in obese children with the homozygous (-866 A/A) mutation of UCP2 than in equally obese children with heterozygous mutation or the normal genotype. High glucose-stimulated insulin response is associated with high plasma C20:3n-6 and C20:4n-6 values only in obese children with the G allele of the -866 G/A polymorphism.
Bokor
Szilvia
S
Department of Paediatrics, University of Pécs, Pécs, Hungary.
Csernus
Katalin
K
Erhardt
Eva
E
Burus
István
I
Molnár
Dénes
D
Decsi
Tamás
T
D016718:Arachidonic Acid / Q000097:blood; D002648:Child; D043371:Fatty Acids, Omega-6 / Q000235:genetics*; D005231:Fatty Acids, Unsaturated / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000235:genetics; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000097:blood; D007473:Ion Channels / Q000235:genetics*; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D010743:Phospholipids / Q000097:blood; D000071246:Uncoupling Protein 2
D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D007328:Insulin; D007473:Ion Channels; D024101:Mitochondrial Proteins; D010743:Phospholipids; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2; D016718:Arachidonic Acid