title: Cytokeratin expression in squamous cell carcinoma arising from hidradenitis suppurativa (acne inversa).
abstract: We have studied cytokeratin (CK) expression in two cases of well-differentiated and poorly differentiated squamous cell carcinoma (SCC) arising from hidradenitis suppurativa (HS) (acne inversa). In both cases, type A (infundibular-like keratinized) epithelia were observed. In type A epithelia, CK 1 and 10 expressions were decreased, and CK 14 and 17 were detectable in the whole layers. CK 7, 8, 15, 16 and 18 were not detected in type A epithelia. In tumor nests of well-differentiated SCC, CK 1 and 10 expressions were downregulated, and CK 14 expression was upregulated. In tumor nests of poorly differentiated SCC, CK 1 and 10 were not expressed, but simple epithelial keratins (CK 8, 18 and 19) were expressed. These changes of CK expression are related to malignant transformation from the sinus tract (type A epithelium) in HS to SCC.
authors: Department of Dermatology, Mie University Graduate School of Medicine, Mie, Japan. kuroichi@clin.medic.mie-u.ac.jp
authors: Ichiro
authors: I
authors: Kurokawa
authors: Keisuke
authors: K
authors: Nishimura
authors: Kei-ichi
authors: K
authors: Yamanaka
authors: Hitoshi
authors: H
authors: Mizutani
authors: Airo
authors: A
authors: Tsubura
authors: Jean
authors: J
authors: Revuz
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D017809:Fatal Outcome; D017497:Hidradenitis Suppurativa / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D007633:Keratins