Hospital-based case series of 175 cases of serologically confirmed brucellosis in Bikaner.
OBJECTIVE
To study the clinical spectrum of brucellosis in Bikaner (Northwest India).


METHODS
A total of 175 cases were diagnosed as brucellosis during the period of six year (June 1997 to May 2003). They were studied for clinical profile and treated by rifampicin and doxycyclin and additionally streptomycin for initial 14 days in patients of neurobrucellosis. These patients were followed up to 3 months.


RESULTS
Patients of brucellosis presented with a wide spectrum of clinical manifestations. Out of 175 cases 155 were from rural area. Age ranged between 12-60 years (124 males, 51 females). Analysis of risk factors revealed history of raw milk ingestion (86.86%), occupational contact with animals (81.14%), handling of infected material (62.28%), household contact (16%) and 2 patients were veterinarian. Joint pain (83.43%) and fever (77.71%) were the commonest presenting feature. Sacroiliac joint was most commonly involved (46.86%). 31 cases had involvement of multiple joints. Other mode of presentation were neurobrucellosis (18.86%), manifested as polyradiculoneuropathy, myeloradiculopathy, meningoencephalopathy and polyradiculomyeloencephalopathy; predominant pulmonary involvement (4.0%) presented as bronchitis, pneumonia and pleural effusion; epididymoorchitis, infective endocarditis, nephrotic syndrome and recurrent abortion. All patients responded well to the treatment.


CONCLUSIONS
Brucellosis is an important emerging zoonotic disease but it is often under-diagnosed due to lack of suspicion and diagnostic facilities despite the fact that cattle farming (an important high risk group) is one of the main occupation in rural area. This report should infuse the awareness about this reemerging disease specifically in high-risk group.
Kochar
D K
DK
Department of Medicine and Microbiology, S.P. Medical College, Bikaner.
Gupta
B K
BK
Gupta
Anjli
A
Kalla
A
A
Nayak
K C
KC
Purohit
S K
SK
D000293:Adolescent; D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000453:epidemiology; D002006:Brucellosis / Q000453:epidemiology* / Q000635:transmission; D002648:Child; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005516:Food Microbiology; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008590:Meningoencephalitis / Q000382:microbiology; D008875:Middle Aged; D008892:Milk / Q000382:microbiology; D009784:Occupational Diseases / Q000453:epidemiology; D009920:Orchitis / Q000382:microbiology; D010996:Pleural Effusion / Q000382:microbiology; D011446:Prospective Studies; D012293:Rifampin / Q000627:therapeutic use; D012307:Risk Factors; D012423:Rural Health; D013307:Streptomycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D004318:Doxycycline; D012293:Rifampin; D013307:Streptomycin