[Clinical course and findings in and differential diagnosis of subacute sclerosing panencephalitis].
The clinical features of subacute sclerosing panencephalitis (SSPE) include the following : stage I, behavioral changes; stage II, myoclonus and motor deterioration; stage III, mental and motor deterioration to coma; stage IV, a vegetative state. Anti-measles titers of serum and cerebrospinal fluid (CSF) are elevated in the patients with SSPE. CSF IgG levels and IgG index are also elevated in SSPE. The characteristic electroencephalography in stage II of SSPE shows periodic high voltage slow wave bursts. In the early stage, psychiatric diseases and epilepsy should be ruled out. Neurodegenerative diseases and other encephalitis/encephalopathy should be also excluded.
Ichiyama
Takashi
T
Department of Pediatrics, Yamaguchi University School of Medicine.
D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D008459:Measles virus / Q000276:immunology; D009207:Myoclonus; D013344:Subacute Sclerosing Panencephalitis / Q000175:diagnosis / Q000503:physiopathology
D000914:Antibodies, Viral; D015415:Biomarkers; D007074:Immunoglobulin G