title: Effect of enamel matrix proteins on the treatment of intrabony defects: a split-mouth randomized controlled trial study.
abstract: The objective of this split-mouth, double-blind, randomized controlled trial was to compare the clinical effect of treatment of 2- or 3-wall intrabony defects with open flap debridement (OFD) combined or not with enamel matrix proteins (EMP). Thirteen volunteers were selected with one pair of or more intrabony defects and probing pocket depth (PPD) > or = 5 mm. All individuals received instructions regarding oral hygiene and were submitted to scaling and root planing. Each participant received the two treatment modalities: test sites were treated with OFD and EMP, and control sites received only OFD. After 6 months, a significant reduction was observed in PPD for the EMP group (from 6.42 +/- 1.08 mm to 2.67 +/- 1.15 mm) and for the OFD group (from 6.08 +/- 1.00 mm to 2.00 +/- 0.95 mm) (p < 0.0001), but with no significant difference between groups (p = 0.13). A significant gain in relative attachment level (RAL) was observed in both groups (EMP: from 13.42 +/- 1.88 mm to 10.75 +/- 2.26 mm, p < 0.001; OFD: from 12.42 +/- 1.98 mm to 10.58 +/- 2.23 mm, p = 0.013), but with no significant difference between groups (p = 0.85). Gingival recession (GR) was higher in the EMP group (from 1.08 +/- 1.50 mm to 2.33 +/- 1.43 mm; p = 0.0009) than in the OFD group (from 0.66 +/- 1.15 mm to 1.16 +/- 1.33 mm; p = 0.16), but this difference was not significant (p = 0.06). In conclusion, the results showed that OFD combined with EMP was not able to improve treatment of intrabony defects compared to OFD alone.
authors: Department of Stomatology, Division of Periodontics, School of Dentistry, University of São Paulo, Brazil. chambron@usp.br
authors: Daniela
authors: D
authors: Chambrone
authors: Ivan Munhoz
authors: IM
authors: Pasin
authors: Marina Clemente
authors: MC
authors: Conde
authors: Claudio
authors: C
authors: Panutti
authors: Silvia
authors: S
authors: Carneiro
authors: Luiz Antonio Pugliesi Alves de
authors: LA
authors: Lima
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000188:drug therapy* / Q000601:surgery*; D001861:Bone Regeneration / Q000187:drug effects*; D003131:Combined Modality Therapy / Q000379:methods; D003646:Debridement; D003746:Dental Enamel Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D008297:Male; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000601:surgery; D013524:Surgical Flaps; D014092:Tooth Root / Q000187:drug effects
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins