title: Cervical adenocarcinoma in situ: the predictive value of conization margin status.
abstract: OBJECTIVE
  We evaluated the impact of conization margin status on outcomes of patients diagnosed with cervical adenocarcinoma in situ.
  
  
  METHODS
  A retrospective chart review identified patients at a University hospital from 1988-2006 with adenocarcinoma in situ (AIS) on conization.
  
  
  RESULTS
  Seventy-four patients were included. Median follow-up was 26 months. Twenty-two of 74 patients (30%) had positive margins, 46 patients (62%) had negative margins, and 6 patients had indeterminate margins. Of patients with positive margins, 55% (12/22) were diagnosed with residual or recurrent disease, including 3 patients diagnosed with adenocarcinoma on hysterectomy. Thirteen percent of patients with negative conization margins (6/46) were diagnosed with residual or recurrent disease, including 2 patients diagnosed with adenocarcinoma during follow-up. Cold knife conization resulted in a significantly higher number of negative margins compared to other conization procedures (P = .013).
  
  
  CONCLUSIONS
  Even with negative conization margins, women still face a risk of residual, recurrent, or invasive disease.
authors: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia School of Medicine, Charlottesville 22908-0712, USA. jly2y@virginia.edu
authors: Jennifer L
authors: JL
authors: Young
authors: Amir A
authors: AA
authors: Jazaeri
authors: Jason A
authors: JA
authors: Lachance
authors: Mark H
authors: MH
authors: Stoler
authors: William P
authors: WP
authors: Irvin
authors: Laurel W
authors: LW
authors: Rice
authors: Willie A
authors: WA
authors: Andersen
authors: Susan C
authors: SC
authors: Modesitt
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology*; D002584:Cervix Uteri / Q000473:pathology*; D019092:Conization; D005260:Female; D006801:Humans; D008875:Middle Aged; D018365:Neoplasm, Residual; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology*