Eta(1)-2-pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): a delicate balance between stability and CO liberation.
An evaluation of the CO releasing ability of iron(II) and molybdenum(II) complexes has facilitated the discovery of the most rapid CO releaser, namely [Mo(CO)(3)(eta(5)-C(5)H(5))(eta(1)-{O}-C{=O}-O-CMe=CH-COMe=CBr)]BF(4) (CORM-F10), reported to date. The rate of CO release is related to the overall solution phase stability of the transition metal carbonyl complex. The cytotoxicity and vasodilatory properties of CORM-F10 have been determined.
Fairlamb
Ian J S
IJ
Department of Chemistry, University of York, Heslington, York, UK, YO10 5DD. ijsf1@york.ac.uk
Lynam
Jason M
JM
Moulton
Benjamin E
BE
Taylor
Ian E
IE
Duhme-Klair
Anne K
AK
Sawle
Philip
P
Motterlini
Roberto
R
D000818:Animals; D001011:Aorta / Q000187:drug effects; D002248:Carbon Monoxide / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D004355:Drug Stability; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry*; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology*
C524576:CORM-F10; C524575:CORM-F4; D009942:Organometallic Compounds; D011753:Pyrones; D014665:Vasodilator Agents; D002248:Carbon Monoxide; D008982:Molybdenum; D007501:Iron