Rectal carcinoma after radiotherapy for cervical carcinoma in patients with a family history of colorectal carcinoma: report of two cases.
Rectal carcinoma is a rare, but well documented late complication of pelvic irradiation. Little is known about the factors predisposing to the development of radiation-associated rectal carcinoma. We present two patients who developed rectal carcinoma 17 and 26 years after radiotherapy for carcinoma of the uterine cervix. In one patient, mutation in exon 4 of the hMLH1 gene was detected. Radiation-associated rectal carcinoma represents a rare late toxicity of radiotherapy for cervical carcinoma that may occur in patients with a family history of colorectal carcinoma, including hereditary non-polyposis colorectal cancer.
Melichar
B
B
Department of Oncology & Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic.
Ryska
A
A
Krepelová
A
A
Holecková
P
P
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D000070957:MutL Protein Homolog 1; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D011878:Radiotherapy / Q000009:adverse effects*; D012004:Rectal Neoplasms / Q000209:etiology* / Q000235:genetics; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
D048868:Adaptor Proteins, Signal Transducing; C501486:MLH1 protein, human; D009687:Nuclear Proteins; D000070957:MutL Protein Homolog 1