Effect of carbimazole induced hypothyroidism and thyroxine replacement on the growth of the long bones in albino rats of different age groups.
To evaluate the effect of carbimazole induced hypothyroidism and thyroxine replacement, on the growth of long bones of albino rats of different age groups. Experimental albino rats were developed with carbimazole and carbimazole plus thyroxine for a period of six weeks. At the end of the experiment the animals were sacrificed, fixed and processed to demonstrate the bony and cartilaginous parts. The ulna and tibia of both sides were measured for intact bone length & diameter and the data compared. The reduction in length and circumference observed, at the end of experiment, in ulna was 10.89%, & 11.94% and in tibia it was 12.52%, 14.81% in carbimazole treated group respectively, while in carbimazole plus thyroxin treated group the reduction in length & circumference of ulna was 1.37% & 1.88% and in tibia it was 1.86% & 3.08% respectively. They were compared to their age matched controls. The reduction in length and circumference in ulna was 5.58% & 6.25% and 6.42% and 5.88% in tibia respectively among the carbimazole treated animals while in the carbimazole plus thyroxine treated animals the reduction was only 0.63% and 3.12% in ulna and 0.91% and 1.06% in tibia respectively. The results show that hypothyroidism and its replacement therapy affects the endochondral as well as periosteal bone growth and results in reduction in length as well as circumference of long bones.
Ahmed
Masood
M
Department of Anatomy, Baqai Medical University, Karachi, Pakistan. ghulamali48@hotmail.com
Sarwar
Muhammad
M
Ahmed
Iftekhar
I
Qureshi
G A
GA
Makhdoom
A
A
Parvez
S H
SH
D000375:Aging / Q000502:physiology*; D000417:Albinism / Q000235:genetics; D000818:Animals; D013956:Antithyroid Agents / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects*; D002231:Carbimazole / Q000009:adverse effects*; D020249:Hormone Replacement Therapy / Q000379:methods; D007037:Hypothyroidism / Q000139:chemically induced* / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D011922:Rats, Mutant Strains; D013974:Thyroxine / Q000627:therapeutic use*; D013977:Tibia / Q000254:growth & development; D014457:Ulna / Q000254:growth & development
D013956:Antithyroid Agents; D002231:Carbimazole; D013974:Thyroxine