Left ventricular remodeling and change of systolic function after closure of patent ductus arteriosus in adults: device and surgical closure.
BACKGROUND
Left ventricular (LV) remodeling and predictors of LV systolic function late after closure of patent ductus arteriosus (PDA) in adults remain to be clearly demonstrated.


METHODS
In 45 patients with PDA, including 28 patients who received successful occlusion using the Amplatzer device (AD group) (AGA, Golden Valley, MN) and 17 patients who received surgical closure (OP group), echocardiography studies were performed before closure and 1 day (AD group) or within 7 days (OP group) after closure, and then were repeated at > or = 6 months (17 +/- 13 months).


RESULTS
In both groups, LV ejection fraction (EF) and end-diastolic volume index were significantly decreased immediately after closure, whereas end-systolic volume index did not change. During the long-term follow-up period, end-systolic as well as end-diastolic volume indices decreased significantly in both groups and LV EF recovered compared to the immediate postclosure state. However, LV EF remained low compared to the preclosure state. Five patients (11.1%) including 3 patients in the AD group and 2 patients in the OP group showed persistent late LV systolic dysfunction (EF <50%). In stepwise, multiple logistic regression analysis, preclosure EF was the only independent predictor of late normal postclosure EF (odds ratio, 1.230; 95% CI, 1.054-1.434; P = .008). Receiver operating characteristic curve analysis showed that preclosure EF > or = 62% had a sensitivity of 72% and a specificity of 83% for predicting late normal LV EF after closure.


CONCLUSIONS
Left ventricular EF remains low late after PDA closure compared with preclosure state in adults. Preclosure LV EF is the best index to predict late postclosure LV EF.
Jeong
Young-Hoon
YH
Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Yun
Tae-Jin
TJ
Song
Jong-Min
JM
Park
Jung-Jun
JJ
Seo
Dong-Man
DM
Koh
Jae-Kon
JK
Lee
Se-Whan
SW
Kim
Mi-Jeong
MJ
Kang
Duk-Hyun
DH
Song
Jae-Kwan
JK
D000328:Adult; D006348:Cardiac Surgical Procedures / Q000295:instrumentation / Q000379:methods; D004374:Ductus Arteriosus, Patent / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D013599:Systole; D020257:Ventricular Remodeling