Cholesterol-lowering ability of a phytostanol softgel supplement in adults with mild to moderate hypercholesterolemia.
Plant sterols, incorporated into spreads and other food sources, have been shown to lower serum cholesterol concentrations. The effect of phytostanol supplementation in softgel form has not been assessed. Our objective was to examine the effects of sitostanol as sitostanol ester in softgel form on serum lipid concentrations in hypercholesterolemic individuals. Thirty hypercholesterolemic adults were supplemented with 1.6 g of free phytostanol equivalents as phytostanol ester (2.7 g stanol esters) or placebo per day for 28 d in a randomized, double-blind, parallel study design. Phytostanol supplementation resulted in a significant decrease in total cholesterol (TC) (-8%) and LDL-cholesterol (-9%). There were no alterations in concentrations of HDL-cholesterol or TG. Nor were the ratios of LDL/HDL or TC/HDL altered significantly. Thus, use of phytostanol ester softgel supplements improved serum total and LDL-cholesterol concentrations in hypercholesterolemic individuals.
Woodgate
Derek
D
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 5B6, Canada.
Chan
Christina H M
CH
Conquer
Julie A
JA
D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D008078:Cholesterol, LDL / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012855:Sitosterols / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D012855:Sitosterols; C407042:plant stanol ester
Clin Chem. 1972 Jun;18(6):499-502
4337382
Am J Clin Nutr. 2002 Dec;76(6):1272-8
12450893
Am J Clin Nutr. 2000 Apr;71(4):908-13
10731496
N Engl J Med. 1995 Nov 16;333(20):1308-12
7566021
Br J Nutr. 2002 Nov;88(5):479-88
12425728
Monogr Atheroscler. 1981;10:1-219
7231433
Eur J Nutr. 2003 Jun;42(3):154-64
12811473
J Lipid Res. 2003 Sep;44(9):1713-9
12730296
Eur J Clin Nutr. 2004 Mar;58(3):503-9
14985690
Diabetologia. 1994 Aug;37(8):773-80
7988779
J Nutr. 2004 Jun;134(6):1395-9
15173402
Eur J Clin Nutr. 1998 May;52(5):334-43
9630383
Atherosclerosis. 1999 Aug;145(2):279-85
10488954
J Lipid Res. 1995 Aug;36(8):1807-12
7595101
BMJ. 2000 Mar 25;320(7238):861-4
10731187
Atherosclerosis. 1994 Feb;105(2):217-26
8003098
Lipids. 2003 Apr;38(4):367-75
12848281
J Nutr. 2003 Oct;133(10):3103-9
14519792
Eur J Clin Nutr. 2000 Sep;54(9):715-25
11002384
Am J Cardiol. 2002 Oct 1;90(7):737-40
12356387
Eur J Clin Pharmacol. 1991;40 Suppl 1:S59-63
2044646
Am J Cardiol. 2000 Jul 1;86(1):46-52
10867091
J Lipid Res. 2000 May;41(5):697-705
10787430
Am J Cardiol. 2001 Nov 15;88(10):1157-62
11703963
Am J Clin Nutr. 2002 Jan;75(1):79-86
11756063
J Nutr. 1999 Dec;129(12):2109-12
10573535
Eur J Clin Nutr. 2001 Dec;55(12):1084-90
11781675
J Pediatr. 1993 Feb;122(2):292-6
8429449