Natural killer T (NKT) cell subsets in chlamydial infections.
Natural killer T (NKT) cells are a newly identified unique subset of cells that express both alphabeta T cell receptor and NK cell markers. We investigated the role of NKT cells in modulating adaptive T cell responses in chlamydial infections using human-disease-related chlamydial species. Our study provides in vivo evidence that even closely related pathogens may activate different functional NKT subsets, which can further polarize CD4+ and CD8+ cells in adaptive immune responses.
Yang
Xi
X
Laboratory for Infection and Immunity, Departments of Medical Microbiology and Immunology, University of Manitoba, Winnipeg, Manitoba, Canada. yangxi@cc.umanitoba.ca
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002690:Chlamydia Infections / Q000276:immunology; D002692:Chlamydia trachomatis / Q000378:metabolism; D016993:Chlamydophila pneumoniae / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism*; D008168:Lung / Q000382:microbiology; D008954:Models, Biological; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism
D016693:Receptors, Antigen, T-Cell, alpha-beta