title: Synthesis and antibacterial activity of some novel chiral fluorophoric biscyclic macrocycles.
abstract: Synthesis of chiral permanent fluorophoric biscyclic macrocycles incorporating anthraquinone and (S)-BINOL core is described. Interestingly, the biscyclic macrocycle 1 exhibited remarkable antibacterial activity against most of the pathogenic bacteria in the tested concentrations as compared to the other three compounds 2, 14 and 17 as well as the test control, tetracycline. Further biscyclophanes 1 and 2 exhibited permanent fluorescence sensing property even under highly acidic conditions.
authors: Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India. perumalrajakumar@hotmail.com
authors: Perumal
authors: P
authors: Rajakumar
authors: Subramaniyan
authors: S
authors: Selvam
authors: Vellaisamy
authors: V
authors: Shanmugaiah
authors: Narayanasamy
authors: N
authors: Mathivanan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D011514:Proteus vulgaris / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013050:Spectrometry, Fluorescence; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D047028:Macrocyclic Compounds