Merosin-negative congenital muscular dystrophy: diffusion-weighted imaging findings of brain.
Merosin-negative congenital muscular dystrophy is a rare genetic disease of childhood involving the central and peripheral nervous system. There were high signal intensities throughout the centrum semiovale, periventricular, and sub-cortical white matters on T2-weighted images in a 4-year-old girl with merosin-negative congenital muscular dystrophy. An apparent diffusion coefficient map revealed increased signal intensity and apparent diffusion coefficient values in the periventricular and deep white matters. It may be attributable to increased water content in the white matter because of an abnormal blood-brain barrier rather than to decreased or abnormal myelination.
Alkan
Alpay
A
Department of Radiology, Inonu University School of Medicine, Malatya, Turkey. aalkan@inonu.edu.tr
Sigirci
Ahmet
A
Kutlu
Ramazan
R
Aslan
Mehmet
M
Doganay
Selim
S
Yakinci
Cengiz
C
D001921:Brain / Q000473:pathology*; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007797:Laminin / Q000378:metabolism*; D009136:Muscular Dystrophies / Q000151:congenital / Q000378:metabolism / Q000473:pathology
D007797:Laminin