title: Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis.
abstract: BACKGROUND
  Eosinophilic esophagitis (EE) is an emerging condition where patients commonly present with symptoms of gastroesophageal reflux disease and fail to respond adequately to anti-reflux therapy. Food allergy is currently recognized as the main immunological cause of EE; recent evidence suggests an etiological role for inhalant allergens. The presence of EE appears to be associated with other atopic illnesses.
  
  
  OBJECTIVE
  To report the sensitization profile of both food and inhalant allergens in our EE patient cohort in relation to age, and to profile the prevalence of other allergic conditions in patients with EE.
  
  
  METHODS
  The study prospectively analyzed allergen sensitization profiles using skin prick tests to common food allergens and inhalant allergens in 45 children with EE. Patch testing to common food allergens was performed on 33 patients in the same cohort. Comorbidity of atopic eczema, asthma, allergic rhinitis and anaphylaxis were obtained from patient history.
  
  
  RESULTS
  Younger patients with EE showed more IgE and patch sensitization to foods while older patients showed greater IgE sensitization to inhalant allergens. The prevalence of atopic eczema, allergic rhinitis and asthma was significantly increased in our EE cohort compared with the general Australian population. A total of 24% of our cohort of patients with EE had a history of anaphylaxis.
  
  
  CONCLUSIONS
  In children with EE, the sensitization to inhalant allergens increases with age, particularly after 4 years. Also, specific enquiry about severe food reactions in patients presenting with EE is strongly recommended as it appears this patient group has a high incidence of anaphylaxis.
authors: Medical School, Griffith University, Southport, Australia.
authors: K K N
authors: KK
authors: Sugnanam
authors: J T
authors: JT
authors: Collins
authors: P K
authors: PK
authors: Smith
authors: F
authors: F
authors: Connor
authors: P
authors: P
authors: Lewindon
authors: G
authors: G
authors: Cleghorn
authors: G
authors: G
authors: Withers
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology*; D001315:Australia; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D004802:Eosinophilia / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology; D004941:Esophagitis / Q000209:etiology / Q000276:immunology*; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007223:Infant; D010328:Patch Tests; D012882:Skin Tests
chemical_list: D000485:Allergens