title: Effects of thyroid hormones on memory and on Na(+), K(+)-ATPase activity in rat brain.
abstract: Thyroid hormones (THs), including triiodothyronine (T3) and tetraiodothyronine (T4), are recognized as key metabolic hormones of the body. THs are essential for normal maturation and function of the mammalian central nervous system (CNS) and its deficiency, during a critical period of development, profoundly affects cognitive function. Sodium-potassium adenosine 5'-triphosphatase (Na(+), K(+)-ATPase) is a crucial enzyme responsible for the active transport of sodium and potassium ions in the CNS necessary to maintain the ionic gradient for neuronal excitability. Studies suggest that Na(+), K(+)-ATPase might play a role on memory formation. Moreover, THs were proposed to stimulate Na(+), K(+)-ATPase activity in the heart of some species. In this work we investigated the effect of a chronic administration of L-thyroxine (L-T4) or propylthiouracil (PTU), an antithyroid drug, on some behavioral paradigms: inhibitory avoidance task, open field task, plus maze and Y-maze, and on the activity of Na(+), K(+)-ATPase in the rat parietal cortex and hippocampus. By using treatments which have shown to induce alterations in THs levels similar to those found in hyperthyroid and hypothyroid patients, we aimed to understand the effect of an altered hyperthyroid and hypothyroid state on learning and memory and on the activity of Na(+), K(+)-ATPase. Our results showed that a hyper and hypothyroid state can alter animal behavior and they also might indicate an effect of THs on learning and memory.
authors: Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 - Anexo, CEP 90035-003, Porto Alegre, RS, Brazil. reis.lunardelli@gmail.com
authors: Eleonora Araújo
authors: EA
authors: dos Reis-Lunardelli
authors: Cibele Canal
authors: CC
authors: Castro
authors: Caren
authors: C
authors: Bavaresco
authors: Adriana Simon
authors: AS
authors: Coitinho
authors: Laura Schumacher Schuh
authors: LS
authors: da Trindade
authors: Myriam Fortes
authors: MF
authors: Perrenoud
authors: Rafael
authors: R
authors: Roesler
authors: João José Freitas
authors: JJ
authors: Sarkis
authors: Angela Terezinha
authors: AT
authors: de Souza Wyse
authors: Iván
authors: I
authors: Izquierdo
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D001522:Behavior, Animal; D001921:Brain / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D004334:Drug Administration Schedule; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D011441:Propylthiouracil / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013963:Thyroid Hormones / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000963:Antimetabolites; D013963:Thyroid Hormones; D011441:Propylthiouracil; D000254:Sodium-Potassium-Exchanging ATPase