title: Neurodevelopmental outcome of children with intrauterine growth retardation: a longitudinal, 10-year prospective study.
abstract: One hundred twenty-three children with intrauterine growth retardation were prospectively followed from birth to 9 to 10 years of age in order to characterize their specific neurodevelopmental and cognitive difficulties and to identify clinical predictors of such difficulties. Perinatal biometric data and risk factors were collected. Outcome was evaluated at age 9 to 10 by neurodevelopmental, cognitive, and school achievement assessments. Sixty-three children served as controls who were appropriate for gestational age. Significant differences in growth (P < .001), neurodevelopmental scores (P < .001), intelligence quotient (IQ) (P < .0001), and school achievements measured by the Kaufmann Assessment Battery for Children (P < .001) were found between the children with intrauterine growth retardation and controls. Children with intrauterine growth retardation demonstrated a specific profile of neurocognitive difficulties at school age, accounting for lower school achievements. The best perinatal parameter predictive of neurodevelopment and IQ was the Cephalization Index (P < .001). Somatic catch-up growth at age 2 and at age 9 to 10 correlated with favorable outcome at 9 to 10 years of age.
authors: Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv University, Israel.
authors: Yael
authors: Y
authors: Leitner
authors: Aviva
authors: A
authors: Fattal-Valevski
authors: Ronny
authors: R
authors: Geva
authors: Rina
authors: R
authors: Eshel
authors: Hagit
authors: H
authors: Toledano-Alhadef
authors: Michael
authors: M
authors: Rotstein
authors: Haim
authors: H
authors: Bassan
authors: Bella
authors: B
authors: Radianu
authors: Ora
authors: O
authors: Bitchonsky
authors: Ariel J
authors: AJ
authors: Jaffa
authors: Shaul
authors: S
authors: Harel
mesh_terms: D001699:Biometry / Q000379:methods; D016022:Case-Control Studies; D002648:Child; D003072:Cognition Disorders / Q000209:etiology*; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000145:classification / Q000503:physiopathology* / Q000523:psychology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors