title: p53 and MIB-1 expression of esophageal carcinoma concominant with achalasia.
abstract: Achalasia, insufficient relaxation of the lower esophageal sphincter (LES) causes the retention and stasis of food and secretions, chronic hyperplastic esophagitis and eventual malignant transformation. p53 alternation has been suggested to play an important role in the malignant transformation. A 53-year-old man was endoscopically followed up for esophageal achalasia for seven years, and endoscopy revealed an ulcerative region in the upper thoracic esophagus, and histopathologically the biopsy specimens showed moderately differentiated squamous cell carcinoma. In resected specimens, p53 staining was strong and diffuse in the tumor and MIB-1 immunoreactivity was strong and patchy in the tumor and the basal layer of squamous mucosa of the esophagus. No staining for either immunostains was noted in normal esophageal mucosa. It is necessary for patients with esophageal achalasia to be followed-up with endoscopy, and that p53 and MIB-1 immunostaining of biopsy specimens should be performed to detect pre-cancerous lesions.
authors: Department of Digestive Surgery, Institute of Health and Biosciences, The University of Tokushima Graduate School, Tokushima, Japan takassan@clin.med.tokushima-u.ac.jp
authors: Takashi
authors: T
authors: Iwata
authors: Nobuhiro
authors: N
authors: Kurita
authors: Masaki
authors: M
authors: Nishioka
authors: Hidenori
authors: H
authors: Miyamoto
authors: Shingo
authors: S
authors: Wakatsuki
authors: Toshiaki
authors: T
authors: Sano
authors: Seiki
authors: S
authors: Tashiro
authors: Mitsuo
authors: M
authors: Shimada
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000378:metabolism*; D004931:Esophageal Achalasia / Q000150:complications* / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000150:complications* / Q000378:metabolism*; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53