title: Use of (99m)Tc-sulesomab for the diagnosis of prosthesis infection after total joint arthroplasty.
abstract: This study aimed to evaluate the diagnostic efficacy of antigranulocyte scintigraphy using the antibody fragment (99m)Tc-sulesomab (LeukoScan) for the diagnosis of prosthesis infection in patients with total hip or knee arthroplasty. The results from 19 patients with suspected total joint arthroplasty infection who had undergone a three-phase bone scan and a subsequent examination with (99m)Tc-sulesomab during a 1-year period were reviewed. Twelve patients were shown to have prosthesis infection on culture of aspirated synovial fluid or intra-operative samples. The overall sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy for (99m)Tc-sulesomab were 75%, 86%, 90%, 66% and 79%, respectively, compared with 54%, 83%, 88%, 45% and 63%, respectively, for the three-phase bone scan. This study showed that (99m)Tc-sulesomab had good diagnostic value for the detection of prosthesis infection. The combination of (99m)Tc-sulesomab with other laboratory or imaging examinations may improve diagnostic performance in prosthesis infection and should be investigated further.
authors: Department of Orthopaedic Surgery, University Hospital of Ioannina, University of Ioannina School of Medicine, Ioannina, Greece. epakos@yahoo.gr
authors: E E
authors: EE
authors: Pakos
authors: A D
authors: AD
authors: Fotopoulos
authors: K S
authors: KS
authors: Stafilas
authors: I
authors: I
authors: Gavriilidis
authors: G
authors: G
authors: Al Boukarali
authors: S
authors: S
authors: Tsiouris
authors: T A
authors: TA
authors: Xenakis
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D058846:Antibodies, Monoclonal, Murine-Derived; D019643:Arthroplasty, Replacement; D005260:Female; D006621:Hip Joint / Q000000981:diagnostic imaging; D006622:Hip Prosthesis / Q000009:adverse effects*; D006784:Hospitals, Teaching; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging; D007720:Knee Prosthesis / Q000009:adverse effects*; D049268:Positron-Emission Tomography; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013669:Technetium Tc 99m Medronate
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D019275:Radiopharmaceuticals; C101172:Sulesomab; D013669:Technetium Tc 99m Medronate