title: The common biology of cancer and ageing.
abstract: At first glance, cancer and ageing would seem to be unlikely bedfellows. Yet the origins for this improbable union can actually be traced back to a sequence of tragic--and some say unethical--events that unfolded more than half a century ago. Here we review the series of key observations that has led to a complex but growing convergence between our understanding of the biology of ageing and the mechanisms that underlie cancer.
authors: Cardiology Branch, NIH, NHLBI, Building 10/CRC 5-3330, 10 Center Drive, Bethesda, Maryland 20892, USA. finkelt@nih.gov
authors: Toren
authors: T
authors: Finkel
authors: Manuel
authors: M
authors: Serrano
authors: Maria A
authors: MA
authors: Blasco
mesh_terms: D000818:Animals; D001343:Autophagy; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology*; D042822:Genomic Instability / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000201:enzymology / Q000235:genetics / Q000378:metabolism
chemical_list: D019098:Telomerase