Human oncogene tissue-specific expression level significantly correlates with sequence compositional features.
To explore whether there exist correlations between human gene expressions and corresponding sequence features, the expression levels for 81 oncogenes in 24 human tissues were collected and correlated with 159 sequence features. It was found that there do exist significant correlations between them, some of which are of significance to understanding translational selection on sequence features of human genes and some have important implications for diagnosing cancers.
Zhou
Yan
Y
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China.
Ma
Bin-Guang
BG
Zhang
Hong-Yu
HY
D001483:Base Sequence; D003062:Codon / Q000235:genetics*; D006801:Humans; D009857:Oncogenes / Q000235:genetics*; D009928:Organ Specificity
D003062:Codon