title: Endoscopic ultrasound-guided fine-needle aspiration of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a report of 2 cases with literature review.
abstract: Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas is rare. Histologically it mimics the giant cell tumor of the bone and may be associated with a ductal adenocarcinoma. We recently encountered two such cases, both of which were biopsied by EUS-guided FNA. Abundant multinucleated osteoclast-like giant cells and many uniform mononuclear cells were present in case 1 so that the diagnosis was made. In case 2, many mononuclear tumor cells with vacuolated and basophilic cytoplasm were present, and rare osteoclast-like giant cells were seen. A diagnosis of adenocarcinoma was made. In both cases, no conspicuous nuclear pleomorphism was noted in the mononuclear cells or the multinucleated giant cells. The histology of case 2 revealed a pure undifferentiated carcinoma with osteoclast-like giant cells. In addition, a liver biopsy revealed globular amyloidosis. To our knowledge, this is the first report of pancreatic undifferentiated carcinoma with osteoclast-like giant cells sampled by EUS-guided FNA and the first case of hepatic globular amyloidosis associated with this tumor.
authors: Department of Pathology and Laboratory Medicine, University of California Irvine Medical Center, Orange, California, USA.
authors: Shefali
authors: S
authors: Chopra
authors: Mark Li-Cheng
authors: ML
authors: Wu
authors: David K
authors: DK
authors: Imagawa
authors: John
authors: J
authors: Lee
authors: Mai
authors: M
authors: Gu
mesh_terms: D000369:Aged, 80 and over; D000686:Amyloidosis / Q000473:pathology; D044963:Biopsy, Fine-Needle / Q000379:methods; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D019160:Endosonography / Q000379:methods; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*