[Toxicity of intravitreal injections of antibiotics and antivirals].
Intravitreal injections of antivirals, antifungals and antibiotics are very efficacious in the management of intraocular infections, which is not the case with per os, intravenous or peribulbar administration. However, these drugs have some toxic potential, more pronounced if used in intraocular condition. Being too toxic, aminoglycosides have been replaced by Ceftazidime and Vancomycine in the management of bacterial endophthalmitis. Efficacy of these drugs for prophylactic use is not demonstrated and their toxic potential remains to be kept in mind.
Libert
J
J
Service d'Ophtalmologie, Hôpital St Pierre, Universitè Libre de Bruxelles, Bruxelles. info@stpierre-bru.be
D000617:Aminoglycosides / Q000008:administration & dosage / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics; D019072:Antibiotic Prophylaxis / Q000009:adverse effects*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects; D002442:Ceftazidime / Q000627:therapeutic use; D009877:Endophthalmitis / Q000188:drug therapy; D015817:Eye Infections / Q000188:drug therapy*; D015774:Ganciclovir / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007267:Injections / Q000009:adverse effects*; D014640:Vancomycin / Q000627:therapeutic use; D014822:Vitreous Body / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents; D000998:Antiviral Agents; D014640:Vancomycin; D002442:Ceftazidime; D015774:Ganciclovir