Combinations of WOX activities regulate tissue proliferation during Arabidopsis embryonic development.
Tissue growth as the result of cell division is an essential part of embryonic development. Previous studies have shown that STIMPY (STIP)/WOX9, a homeodomain transcription factor of the Arabidopsis thaliana WOX family, is required for maintaining cell division and preventing premature differentiation in emerging seedlings. Here we present evidence that STIP performs similar functions during embryogenesis. Complete loss of STIP activity results in early embryonic arrest, most likely due to a failure in cell division. STIMPY-LIKE (STPL)/WOX8, a close homolog of STIP in Arabidopsis, also positively regulates early embryonic growth and can replace STIP function when expressed under the STIP promoter. STPL shares redundant functions with a more distantly related member of the WOX family, WOX2, in regulating embryonic apical patterning. These findings show that combinatorial action of WOX transcription factors is essential for Arabidopsis embryonic development.
Wu
Xuelin
X
Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Chory
Joanne
J
Weigel
Detlef
D
D017360:Arabidopsis / Q000196:embryology / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D018507:Gene Expression Regulation, Developmental; D018506:Gene Expression Regulation, Plant; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D029681:Arabidopsis Proteins; D018398:Homeodomain Proteins; C500834:STIMPY protein, Arabidopsis; D014157:Transcription Factors; C525391:WOX2 protein, Arabidopsis; C525390:WOX8 protein, Arabidopsis
Development. 2002 Sep;129(17):3965-74
12163400
Plant Cell. 2002 Apr;14(4):833-45
11971138
J Exp Bot. 2001 Mar;52(Spec Issue):403-11
11326046
Science. 2003 Aug 1;301(5633):653-7
12893945
Development. 1996 Jan;122(1):87-96
8565856
Annu Rev Genet. 2006;40:77-105
17094738
Cell. 2004 Jan 9;116(1):109-19
14718171
Development. 2005 Feb;132(4):841-9
15659481
Annu Rev Genet. 2004;38:587-614
15568987
Plant Cell. 2005 Jan;17(1):61-76
15598805
Plant Physiol. 2002 Jun;129(2):691-705
12068112
Curr Biol. 2005 Mar 8;15(5):436-40
15753038
Trends Plant Sci. 2006 Oct;11(10):492-8
16949326
Development. 2002 Jun;129(12):2797-806
12050130
Development. 1999 Apr;126(8):1563-70
10079219
Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7360-4
1502145
Plant J. 1999 Oct;20(2):259-63
10571886
Genome Res. 2003 Mar;13(3):524-30
12618384
Development. 1999 Apr;126(7):1387-95
10068632
Genes Dev. 2002 Oct 1;16(19):2566-75
12368267
Mech Dev. 2003 Nov;120(11):1395-406
14623445
Plant Mol Biol. 2000 Aug;43(5-6):607-20
11089864
Development. 2005 Aug;132(16):3577-85
16077088
Cytometry. 1995 Feb 1;19(2):103-6
7743889
Science. 2006 Jun 9;312(5779):1520-3
16763149
Plant Cell. 1993 Dec;5(12):1711-23
8305869
Nature. 2007 Apr 12;446(7137):811-4
17429400
Curr Opin Plant Biol. 2005 Feb;8(1):32-7
15653397
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15694-9
16227434
Development. 2004 Feb;131(3):657-68
14711878
Plant Cell. 1994 Dec;6(12):1713-1729
12244232
Plant Cell. 2003 Jul;15(7):1563-77
12837947
Development. 1994 Oct;120(10):2967-78
10484674
Nature. 2003 Nov 13;426(6963):147-53
14614497
Plant Cell. 2004;16 Suppl:S190-202
15100395
Science. 1999 Oct 8;286(5438):316-8
10514379
Development. 2007 May;134(9):1653-62
17376809
Development. 1998 Feb;125(3):521-31
9425146
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9873-8
15205481
Development. 2003 Aug;130(16):3735-45
12835390
Cell. 1994 Jul 1;77(7):1051-62
8020095
Cell. 1996 Aug 9;86(3):423-33
8756724
Plant Cell. 1997 Jun;9(6):841-57
9212461