Neuropsychiatric effects of prescription drug abuse.
Prescription drugs have become a major category of abused substances, and there is evidence that the prevalence of prescription drug abuse may soon overtake that of illicit drugs. Study of prescription drugs has been hampered by vague terminology, since prescription drugs are only separated from other drugs of abuse by social and legal constructs. Reviewed herein is published literature on the abuse of four major categories of abused prescription drugs: sedative-hypnotics, stimulants, anabolic steroids, and anticholinergics. The review emphasizes evidence regarding the effects of these drugs on neural systems. Other abused prescription drugs that fall outside of the major categories are also briefly addressed.
Caplan
Jason P
JP
Behavioral Health Services, UPH Hospital - Kino Campus, 5th Floor, 2800 E. Ajo Way, Tucson, AZ, USA. jcaplan@email.arizona.edu
Epstein
Lucy A
LA
Quinn
Davin K
DK
Stevens
Jonathan R
JR
Stern
Theodore A
TA
D000697:Central Nervous System Stimulants / Q000009:adverse effects; D018680:Cholinergic Antagonists / Q000009:adverse effects; D011307:Drug Prescriptions; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects; D011619:Psychotropic Drugs / Q000009:adverse effects*; D013256:Steroids / Q000009:adverse effects; D019966:Substance-Related Disorders / Q000209:etiology*
D000697:Central Nervous System Stimulants; D018680:Cholinergic Antagonists; D006993:Hypnotics and Sedatives; D011619:Psychotropic Drugs; D013256:Steroids
Emerg Med (Fremantle). 2003 Aug;15(4):376-82
14631706
J Am Acad Child Adolesc Psychiatry. 1998 Jun;37(6):573-4
9628076
Arch Gen Psychiatry. 2006 Sep;63(9):957-68
16952998
JAMA. 1998 Apr 8;279(14):1100-7
9546570
Br J Psychiatry. 1984 Sep;145:300-3
6478124
Curr Pharm Des. 2002;8(1):5-21
11812247
Med Sci Sports Exerc. 1985 Jun;17(3):354-9
2991700
J Psychiatry Neurosci. 2004 Nov;29(6):452-7
15644986
J Psychoactive Drugs. 1998 Apr-Jun;30(2):137-47
9692375
Psychopharmacology (Berl). 1999 Jun;144(3):220-33
10435388
N Engl J Med. 1996 Mar 14;334(11):707-14
8594431
J Psychopharmacol. 1999;13(1):81-93
10221362
Am J Psychiatry. 2004 Sep;161(9):1718
15337673
Am J Sports Med. 2004 Sep;32(6):1543-53
15310585
J Clin Psychopharmacol. 2002 Dec;22(6):633-4
12454570
Am J Health Syst Pharm. 2004 Jun 15;61(12):1252-7
15259755
Am J Psychiatry. 2006 Jul;163(7):1233-8
16816229
Am J Geriatr Pharmacother. 2006 Dec;4(4):380-94
17296542
Arch Gen Psychiatry. 2000 Feb;57(2):133-40; discussion 155-6
10665615
J Clin Endocrinol Metab. 2001 Nov;86(11):5108-17
11701661
Am J Psychiatry. 2005 Dec;162(12 ):2352-9
16330601
Br J Psychiatry. 2006 Sep;189:213-20
16946355
Addiction. 2003 Oct;98(10):1371-8
14519173
Acta Psychiatr Scand. 1987 Jan;75(1):91-4
3577845
JAMA. 1997 Jul 2;278(1):27-31
9207334
Am J Psychiatry. 2004 Sep;161(9):1722-3; author reply 1723
15337678
Psychopharmacology (Berl). 2005 Nov;183(1):92-102
16228196
Leg Med (Tokyo). 2004 Oct;6(4):233-41
15363448
Pharmacol Ther. 2003 May;98(2):171-95
12725868
J Addict Dis. 1999;18(2):51-6
10334375
J Am Coll Health. 2006 Mar-Apr;54(5):269-78
16539219
Am J Emerg Med. 1992 Sep;10(5):429-30
1642706
Am J Sports Med. 1987 Jul-Aug;15(4):357-61
3661817
J Psychopharmacol. 1998;12(1):103-4
9584975
Psychiatr Serv. 2000 Jul;51(7):928-9
10875961
Br J Sports Med. 2002 Oct;36(5):375-6; discussion 377
12351338
Br J Psychiatry. 1982 May;140:473-4
6125226
J Pharmacol Exp Ther. 2006 Jan;316(1):315-24
16192313
Neuropsychopharmacology. 1993 Jun;8(4):377-86
8512624
Nord J Psychiatry. 2002;56(1):49-52
11869466
J Clin Psychiatry. 1992 Apr;53(4):130-2
1564048
Addiction. 2005 Jan;100(1):96-106
15598197
Arch Gen Psychiatry. 1994 May;51(5):375-82
8179461
N Engl J Med. 2006 May 25;354(21):2294-5
16723627
Arch Gen Psychiatry. 1995 Mar;52(3):219-29
7872850
Subst Use Misuse. 2004 Jun;39(7):1095-116
15387205
Clin Endocrinol (Oxf). 1997 Apr;46(4):497-506
9196614
Clin J Sport Med. 1995;5(1):25-31
7614077
JAMA. 1988 Dec 16;260(23):3441-5
3210283
Pain Physician. 2005 Oct;8(4):335-47
16850056
Neurochem Int. 2004 Jan;44(1):1-7
12963082
J Clin Psychopharmacol. 2003 Jun;23(3):269-80
12826989
Arch Gen Psychiatry. 2000 Feb;57(2):141-7; discussion 155-6
10665616
Am J Psychiatry. 1979 Apr;136(4A):459-60
426119
Am J Psychiatry. 2005 Sep;162(9):1755-6
16135642
Am J Psychiatry. 2006 Mar;163(3):359-61
16513852
J Psychopharmacol. 2007 Mar;21(2):220-4
17329304
J Clin Psychiatry. 2006 Jul;67(7):1062-73
16889449
N Engl J Med. 2000 May 18;342(20):1532
10819660
Drug Alcohol Depend. 2006 Jun;83 Suppl 1:S8-14
16483729
Can J Psychiatry. 2006 Jun;51(7):445-52
16838826
N Engl J Med. 1996 Jul 4;335(1):1-7
8637535
J Sports Med Phys Fitness. 1994 Sep;34(3):292-8
7830394
Drug Alcohol Depend. 2006 Sep 15;84(2):135-43
16480836
Drug Alcohol Depend. 1995 Nov;40(1):73-9
8746927
Am J Psychiatry. 2007 Jan;164(1):174-5
17202569
N Engl J Med. 2006 Apr 6;354(14):1448-50
16598042
JAMA. 1993 Jun 2;269(21):2760-4
8492402
J Clin Psychiatry. 2005;66 Suppl 2:9-13
15762814
Arch Clin Neuropsychol. 2004 Apr;19(3):437-54
15033227
Am J Psychiatry. 2004 Feb;161(2):332-42
14754783
J Community Health. 1999 Apr;24(2):131-45
10202692
J Drug Educ. 2006;36(1):33-45
16981638
J Clin Psychiatry. 2007 Mar;68(3):483-4
17388722
J Clin Psychopharmacol. 1999 Aug;19(4):362-6
10440465
Mayo Clin Proc. 2000 Jul;75(7):711-21
10907387
N Engl J Med. 1978 Oct 12;299(15):834
692571
Can J Psychiatry. 2005 Jul;50(8):457-61
16127963
Adv Alcohol Subst Abuse. 1990;9(1-2):67-82
2198786
NIDA Res Monogr. 1990;102:74-96
2079978
BMJ. 2007 Mar 3;334(7591):444
17332555
Subst Use Misuse. 2005;40(9-10):1189-201
16048813
J Clin Psychiatry. 2003;64 Suppl 11:3-8
14529323
Addiction. 2002 May;97(5):555-62
12033656
Prog Neurobiol. 1996 May;49(1):73-97
8817699
Dis Nerv Syst. 1977 May;38(5):353-5
852367
Br J Psychiatry. 1998 Nov;173:433-8
9926062
Pediatr Clin North Am. 2002 Apr;49(2):435-61
11993292
Pharmacopsychiatry. 2007 Jan;40(1):43-4
17327964
Biol Psychiatry. 1998 May 1;43(9):687-93
9583003
Int Clin Psychopharmacol. 1996 Sep;11(3):199-202
8923099
Am J Psychiatry. 1995 Nov;152(11):1652-8
7485630
J Clin Psychiatry. 2003;64 Suppl 3:36-40
12662132
Psychiatr Clin North Am. 1998 Dec;21(4):829-33
9890124
Pharmacotherapy. 2006 Oct;26(10):1501-10
16999660
Am J Physiol. 1994 Aug;267(2 Pt 1):E331-6
8074213
Biol Psychiatry. 1999 Feb 1;45(3):254-60
10023498
Curr Psychiatry Rep. 2002 Oct;4(5):377-87
12230967
Physiol Behav. 2004 Nov 15;83(2):279-89
15488545
N Engl J Med. 2003 Sep 4;349(10):975-86
12954747
Psychopharmacology (Berl). 2006 Nov;188(4):408-24
17006715
J Clin Psychiatry. 1980 Oct;41(10):351-4
7430078
Acta Psychiatr Scand. 1985 Mar;71(3):297-303
3984771
Sports Med. 2000 Jun;29(6):397-405
10870866
Pediatrics. 2006 Dec;118(6):2472-80
17142533
Am J Psychiatry. 1977 Nov;134(11):1315
911000
J Clin Psychiatry. 1983 Dec;44(12):463-4
6654839
Am J Psychiatry. 2003 Nov;160(11):1909-18
14594733
Subst Use Misuse. 2005;40(4):473-82
15830730
Med Sci Sports Exerc. 1990 Jun;22(3):331-40
2199753
Pharmacopsychiatry. 2000 Jul;33(4):138-41
10958262
Pain Physician. 2006 Oct;9(4):287-321
17066115
Ann Pharmacother. 2005 Jan;39(1):173-6
15572604
Postgrad Med. 2005 Jul;118(1):19-26
16106916
Am J Psychiatry. 2006 Apr;163(4):697-703
16585446
JAMA. 1978 Jun 2;239(22):2365-6
642176
Am J Psychiatry. 2000 Aug;157(8):1291-6
10910793
N Engl J Med. 1987 Feb 12;316(7):363-9
2880292
Drug Alcohol Depend. 1993 Mar;32(1):1-7
8486081
Clin J Sport Med. 1995 Oct;5(4):223-8
7496846
Drug Alcohol Depend. 2004 Jun 11;74(3):311-8
15194209
N Engl J Med. 1990 Nov 15;323(20):1361-6
2233902
Drug Alcohol Depend. 2006 Jun;83 Suppl 1:S4-7
16563663
Clin Neuropharmacol. 2000 Sep-Oct;23(5):281-3
11154097
Br Med J. 1976 Jan 17;1(6002):152
1247752
Hosp Community Psychiatry. 1991 Jun;42(6):580-1
1677920
Drug Alcohol Depend. 2003 Jul 20;71(1):77-86
12821208
Acta Psychiatr Scand. 1984 Jun;69(6):538-42
6741602
Clin J Sport Med. 1996 Jan;6(1):9-14
8925377
Arch Fam Med. 1993 Apr;2(4):429-32
8130923
Psychother Psychosom. 2001 Mar-Apr;70(2):61-5
11244386
J Clin Psychiatry. 2005;66 Suppl 2:28-33
15762817
Clin Chem. 1997 Jul;43(7):1289-92
9216476
Pediatrics. 2003 Jan;111(1):179-85
12509574
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14938-43
9843994
CNS Drugs. 2004;18(1):37-48
14731058
Am J Psychiatry. 2003 Jun;160(6):1071-7
12777264
Am J Addict. 1999 Spring;8(2):161-4
10365196