title: Proton pump inhibitor-responsive chronic cough without acid reflux: a case report.
abstract: BACKGROUND
  Because 24-h esophageal pH monitoring is quite invasive, the diagnosis of gastroesophageal reflux disease (GERD)-associated cough has usually been made based merely on the clinical efficacy of treatment with proton pump inhibitor (PPI).
  
  
  METHODS
  We recently encountered two patients with PPI-responsive chronic non-productive cough for whom switching from bronchodilators and glucocorticosteroids to PPI resulted in improvement of cough. The cough returned nearly to pre-administration level a few weeks after discontinuation of PPI. Though GERD-associated cough was suspected, 24-h esophageal pH monitoring revealed that the cough rarely involved gastric acid reflux. Following re-initiation of PPI, the cough disappeared again.
  
  
  CONCLUSIONS
  PPI may improve cough unrelated to gastric acid reflux.
authors: The Department of Internal Medicine, Imizu City Hospital, Imizu, JapanAbstract. k-nobata@yg7.so-net.ne.jp.
authors: Kouichi
authors: K
authors: Nobata
authors: Hidetsugu
authors: H
authors: Asanoi
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