title: Preoperative serum C-reactive protein level in non-small cell lung cancer.
abstract: We evaluated the significance of the preoperative serum C-reactive protein (CRP) level as a prognostic indicator in patients with non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Two hundred and three patients who had undergone a curative resection of NSCLC were retrospectively reviewed.
  
  
  RESULTS
  The proportion of the tumor size over 3 cm per patient in the CRP-positive group (> or =0.5 mg/dL: n=38) was significantly higher than that in the CRP-negative group (<0.5 mg/dL: n = 165). The proportion of the adenocarcinoma in CRP-positive group was significantly lower than that in CRP-negative group. The overall and disease specific survival rates in the CRP-positive group were significantly lower than the rates in the CRP-negative group. Based on a multivariate analysis, the preoperative serum CRP level was selected as one of the unfavorable indicators regarding survival.
  
  
  CONCLUSIONS
  The preoperative serum CRP level is an independent and significant indicator predictive of a poor prognosis in patients with NSCLC.
authors: Department of Cardiovascular, Thoracic and General Surgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. haramasa@med.miyazaki-u.ac.jp
authors: Masaki
authors: M
authors: Hara
authors: Yasunori
authors: Y
authors: Matsuzaki
authors: Tetsuya
authors: T
authors: Shimuzu
authors: Masaki
authors: M
authors: Tomita
authors: Takanori
authors: T
authors: Ayabe
authors: Yusuke
authors: Y
authors: Enomoto
authors: Toshio
authors: T
authors: Onitsuka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D015996:Survival Rate
chemical_list: D002097:C-Reactive Protein