title: [Herb-drugs interactions].
abstract: Herbal therapeutics are increasingly associated with herb drug interactions. The vast majority of the purported cases is unsubstantiated and misinterpreted. Pharmacological and clinical studies should only be demanded in cases of reliable evidence. First steps to be taken by manufacturers of herbal drugs should be in vitro studies with metabolizing systems like CYP and P-gp. Manufacturers of drugs that are metabolized by modulated systems should be requested to conduct drug specific interaction studies as necessary.
authors: Schaper & Brümmer GmbH & Co. KG, Salzgitter, Germany. Johannes.Freudenstein@Schaper-Bruemmer.de
authors: Johannes
authors: J
authors: Freudenstein
authors: Thomas
authors: T
authors: Nisslein
mesh_terms: D017277:Drug Approval; D004345:Drug Industry / Q000592:standards; D005858:Germany; D041743:Herb-Drug Interactions; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts
references: Phytomedicine. 2004 Feb;11(2-3):98-104
references: 15070158
references: J Geriatr Psychiatry Neurol. 1999 Spring;12(1):7-10
references: 10447148
references: Curr Pharm Des. 2006;12(35):4649-64
references: 17168768
references: J Clin Pharmacol. 2001 Nov;41(11):1149-79
references: 11697750
references: Ann Pharmacother. 2000 Sep;34(9):1013-6
references: 10981246
references: Can J Psychiatry. 2006 Apr;51(5):300-16
references: 16986820
references: Arzneimittelforschung. 2004;54(6):307-13
references: 15282874
references: Int J Clin Pharmacol Ther. 2000 Oct;38(10):500-2
references: 11073292
references: Planta Med. 2004 Sep;70(9):784-91
references: 15386186
references: Br J Clin Pharmacol. 1979 Nov;8(5):483-9
references: 508556
references: Eur J Pharm Sci. 2006 Apr;27(5):501-17
references: 16364611
references: J Clin Invest. 1999 Jul;104(2):147-53
references: 10411543
references: Drugs. 2005;65(9):1239-82
references: 15916450
references: J Psychopharmacol. 2002 Dec;16(4):401
references: 12503845
references: Rapid Commun Mass Spectrom. 2004;18(19):2273-81
references: 15384148