Anti-uveitis and inhibition of fibroblast-like corneal and conjunctival cells by interleukin-1 blockers.
Effects of interleukin-1 (IL-1) blockers, CK130 and CK131, on IL-1-induced uveitis and proliferation of fibroblast-like corneal and conjunctival cells were investigated in this study. It was found that CK130 and CK131 inhibited IL-1-induced uveitis in rat eyes effectively at 3 mg/kg and 10 mg/kg, respectively. Further, CK130 and CK131 inhibited fibroblast-like corneal and conjunctival cell growth effectively at 10-300 microg/ml and 30-300 microg/ml, respectively. It was also found that DNA synthesis was markedly reduced by CK130 and CK131 at 30-100 microg/ml. RNA synthesis was also inhibited by these CK compounds but protein synthesis was little affected or enhanced.
Xuan
B
B
Institute of Ocular Pharmacology and Department of Medical Pharmacology and Toxicology, Texas A&M University College of Medicine, 77843-1114, College Station, TX, USA.
Chiou
G C
GC
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