Effects of nutritional and psychological status in gastrointestinal cancer patients on tolerance of treatment.
OBJECTIVE
To assess the effects of poor nutritional and psychological status on tolerance of cancer treatment and the recovery of physical performance status in patients with gastrointestinal cancer.


METHODS
An epidemiological survey with respect to nutritional and psychological status in patients with gastrointestinal cancer was conducted among 182 operated patients in four provincial-level hospitals from December 2005 to June 2006. The food frequency survey method, state-trait anxiety inventory (STAI) and depression status inventory (DSI) were used to obtain information about the diet and psychological status in the patients. Nutritional status in the participants was reflected by serum albumin (Alb), hemoglobin (HB) and body mass index (BMI).


RESULTS
Alb, protein intake and anxiety were associated with the severity of side effects of treatment. The adjusted relative risk (RR) for Alb, protein intake and anxiety was 3.30 (95% CI: 1.08, 10.10, P = 0.03), 3.25 (95% CI: 1.06, 9.90, P = 0.04) and 1.48 (95% CI: 1.29, 1.70, P < 0.0001), respectively. Moreover, calorie intake, HB and depression were associated with the recovery of physical performance status in the patients. Adjusted relative risk was 2.12 (95% CI: 1.09, 4.03, P = 0.028), 2.05 (95% CI: 1.08, 3.88, P = 0.026) and 1.07 (95% CI: 1.02, 1.12, P = 0.007), respectively.


CONCLUSIONS
Both poor nutrition status and psychological status are independent risk factors for severe side effects of cancer treatment, and have impact on the recovery of physical performance status in patients after treatment.
Tian
Jun
J
Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou 350004, Fujian Province, China. tianjun@mail.fjmu.edu.cn
Chen
Zhen-Chun
ZC
Hang
Li-Fang
LF
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015992:Body Mass Index; D003131:Combined Modality Therapy / Q000009:adverse effects; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy*; D006306:Health Surveys; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status / Q000502:physiology*; D011788:Quality of Life; D011836:Radiation Tolerance / Q000502:physiology*; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism; D013315:Stress, Psychological / Q000503:physiopathology*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D006454:Hemoglobins; D012709:Serum Albumin
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