A new ester isolated from Ferula assa-foetida L.
A new caffeic acid cinnamyl ester (1) was isolated from the n-hexane-soluble fraction of an MeOH extract of the gum resin of Ferula assa-foetida L. The structure was determined to be (2E)-3,4-dimethoxycinnamyl-3-(3,4 diacetoxyphenyl) acrylate on the basis of spectroscopic data including 1D- and 2D-NMR. Compound 1 showed moderate activity for inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.7 cells, with an IC50 value of 54.9 microm.
Abd El-Razek
Mohamed H
MH
Department of Chemistry, National Taiwan University, Roosevelt Road Section 4, Taipei, Taiwan 106, Republic of China. abdelrazek3@yahoo.com
D004952:Esters / Q000737:chemistry* / Q000302:isolation & purification*; D005309:Ferula / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D004952:Esters