Galanin message-associated peptide suppresses growth and the budded-to-hyphal-form transition of Candida albicans.
The expression of the mRNA encoding galanin message-associated peptide (GMAP) in human keratinocytes is upregulated by lipopolysaccharides and exposure to Candida albicans. GMAP has growth-inhibiting activity against C. albicans and inhibits the budded-to-hyphal-form transition, establishing GMAP as a possible new component of the innate immune system.
Rauch
Isabella
I
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstr. 48, A-5020 Salzburg, Austria.
Lundström
Linda
L
Hell
Markus
M
Sperl
Wolfgang
W
Kofler
Barbara
B
D000818:Animals; D001483:Base Sequence; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002478:Cells, Cultured; D019004:Galanin / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid
D008070:Lipopolysaccharides; D012333:RNA, Messenger; C078371:galanin message-associated peptide; D019004:Galanin
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