Contagious bovine pleuropneumonia: a rationale for the development of a mucosal sub-unit vaccine.
Contagious bovine pleuropneumonia (CBPP) remains a major cattle disease in Africa with serious socio-economic consequences. Its eradication requires the development of improved vaccines. Knowledge on this disease and its causing agent, Mycoplasma mycoides subsp. mycoides biotype Small Colony (MmmSC), has been progressing significantly in the last years, opening new areas for vaccine design. Advances were achieved in the understanding of the protective immune responses to MmmSC infection and immunopathological mechanisms allowing the pathogen to escape the host immune response. Based on sequencing and genomic studies, some virulence factors and metabolic pathways were unraveled leading to the identification of potential MmmSC vaccine candidates. Based on these findings, this review presents a scientific strategy to design multi-component sub-unit vaccines for mucosal delivery as the most promising approach for efficient long-term protective vaccines to prevent CBPP.
Dedieu-Engelmann
Laurence
L
CIRAD, Département BIOS, UPR15, TA A15/G, Campus International de Baillarguet, 34398 Montpellier Cedex 5, France. laurence.dedieu@cirad.fr
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D002417:Cattle; D004333:Drug Administration Routes / Q000662:veterinary; D009176:Mycoplasma mycoides / Q000276:immunology*; D011002:Pleuropneumonia, Contagious / Q000517:prevention & control*; D022223:Vaccines, Subunit / Q000008:administration & dosage
D001428:Bacterial Vaccines; D022223:Vaccines, Subunit
Clin Diagn Lab Immunol. 2001 Jan;8(1):85-92
11139200
Genome Res. 2004 Feb;14(2):221-7
14762060
Emerg Infect Dis. 2000 Mar-Apr;6(2):123-32
10756145
Vet J. 2007 Nov;174(3):513-21
17157043
Trends Microbiol. 1999 Dec;7(12):493-9
10603485
Scand J Immunol. 2005 Dec;62(6):528-38
16316420
J Med Microbiol. 1995 Oct;43(4):239-50
7562984
Rev Sci Tech. 1987 Sep;6(3):565-679
32370343
Vet Res. 2006 Sep-Oct;37(5):733-44
16820137
J Bacteriol. 2005 Oct;187(19):6824-31
16166545
Infect Immun. 2002 Jul;70(7):3785-92
12065522
Dev Biol (Basel). 2004;119:99-111
15742622
Infect Immun. 1998 Nov;66(11):5406-13
9784551
Hum Vaccin. 2005 May-Jun;1(3):95-101
17012851
J Comp Pathol. 1997 Aug;117(2):127-36
9352437
Infect Immun. 2003 Aug;71(8):4487-97
12874328
Vet Microbiol. 1998 Jan 16;59(2-3):109-22
9549852
Scand J Immunol. 2006 Oct;64(4):376-81
16970677
J Bacteriol. 2006 Jul;188(13):4926-41
16788201
Dev Biol (Basel). 2003;114:147-60
14677685
Vet Immunol Immunopathol. 2001 Nov;83(1-2):93-105
11604164
Vet Immunol Immunopathol. 2005 Sep 15;107(3-4):217-33
15946743
Rev Sci Tech. 2006 Dec;25(3):999-1011
17361766
Vet Microbiol. 2001 Feb 26;78(4):343-51
11182500
Infect Immun. 2006 Dec;74(12):6929-39
17030584
Res Vet Sci. 2005 Jun;78(3):199-205
15766938
J Vet Med B Infect Dis Vet Public Health. 2003 Aug;50(6):298-303
14629002
J Infect Dis. 2006 Oct 1;194(7):984-92
16960787
Vaccine. 2006 Apr 12;24(16):3279-89
16476510
Vaccine. 2004 Oct 22;22(31-32):4358-64
15474729
Vet Immunol Immunopathol. 2002 Sep 10;87(3-4):291-300
12072249
Rev Sci Tech. 1996 Dec;15(4):1283-308
9190017
Immunol Cell Biol. 2004 Feb;82(1):10-6
14984589
Vet Res. 2006 May-Jun;37(3):487-510
16611560
J Vet Med Sci. 2003 Jan;65(1):69-74
12576707
J Comp Pathol. 2002 Feb-Apr;126(2-3):171-82
11945006
Vet Res. 2006 Jul-Aug;37(4):579-91
16641018
Immunol Lett. 1998 Jan;60(1):37-43
9541461
Zentralbl Veterinarmed B. 1996 Sep;43(7):429-38
8885707