title: Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing?
abstract: A recent study by Forceville and colleagues evaluated the effect of high-dose selenium administration as a treatment for septic shock. The study was negative and conflicts with existing clinical data regarding selenium administration in critically ill patients. Perhaps the key to understanding the differences between these discrepant observations lies in considering the dose and timing of selenium administration.
authors: Daren K
authors: DK
authors: Heyland
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D016638:Critical Illness; D004305:Dose-Response Relationship, Drug; D006801:Humans; D012643:Selenium / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D012643:Selenium
references: JPEN J Parenter Enteral Nutr. 2007 Mar-Apr;31(2):109-18
references: 17308251
references: Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R394-400
references: 15486095
references: Crit Care. 2007;11(4):R73
references: 17617901
references: Intensive Care Med. 2001 Jan;27(1):91-100
references: 11280679
references: Cardiovasc Res. 2004 Nov 1;64(2):279-88
references: 15485687
references: Z Gesamte Inn Med. 1991 Apr;46(5):145-9
references: 1648849
references: Free Radic Biol Med. 1994 Jul;17(1):45-64
references: 7959166
references: Med Klin (Munich). 1997 Sep 15;92 Suppl 3:3-4
references: 9417494
references: Am J Clin Nutr. 1998 Aug;68(2):365-71
references: 9701195
references: Am Surg. 1999 May;65(5):478-83
references: 10231223
references: Intensive Care Med. 2005 Mar;31(3):327-37
references: 15605227
references: Proc Nutr Soc. 2006 Aug;65(3):250-63
references: 16923310
references: Crit Care Med. 2007 Jan;35(1):118-26
references: 17095947
references: Crit Care Med. 1999 Sep;27(9):1807-13
references: 10507602