title: Sudden coronary death, fatal acute myocardial infarction and widespread coronary and myocardial inflammation.
abstract: BACKGROUND
  T-lymphocyte activation within atherosclerotic plaque, and widespread to the myocardium, has been shown in patients with acute coronary syndromes.
  
  
  OBJECTIVE
  To investigate the presence of T-lymphocyte infiltrate at different stages of acute coronary syndromes by studying patients with sudden coronary death, acute myocardial infarction (AMI) and healed infarction, in comparison with patients with myocarditis and patients with non-ischaemic heart failure.
  
  
  METHODS
  72 cases were studied at autopsy: 12 dying of sudden coronary death (group 1), 12 dying <4 weeks (group 2) and 12 dying >4 months after AMI (group 3), 12 with active lymphocytic myocarditis (group 4), 12 with hypertensive heart disease (group 5), and 12 control subjects (group 6). Light microscopy was performed to measure the number of activated T-lymphocytes (CD3+/DR+) in the myocardium and coronary artery wall, and intercellular adhesion molecule-1 (ICAM-1) expression in the myocardium.
  
  
  RESULTS
  Activated T-lymphocyte infiltrates and ICAM-1 myocardial expression in both remote and peri-infarction regions and activated T-lymphocytes within the epicardial coronary artery wall of both the infarct- and non-infarct-related arteries were found in groups 1, 2 and 3, whereas myocardial, but not coronary, infiltrates were found in groups 4 (p<0.001 vs groups 1, 2 and 3 for coronary infiltrates). Groups 5 and 6 had no evidence of myocardial or coronary inflammation (p<0.001 vs groups 1, 2 and 3).
  
  
  CONCLUSIONS
  The study shows the presence of a lymphocytic infiltrate in both coronary arteries and myocardium and a proinflammatory phenotype shift in the myocardium associated with acute coronary thrombosis in patients dying suddenly, shortly, or even late after coronary thrombosis.
authors: Virginia Commonwealth University, VCU Pauley Heart Center, 1200 E Broad Street, Box 980281, Richmond, VA 23298, USA. abbatea@yahoo.com
authors: A
authors: A
authors: Abbate
authors: R
authors: R
authors: Bussani
authors: G
authors: G
authors: Liuzzo
authors: G G L
authors: GG
authors: Biondi-Zoccai
authors: E
authors: E
authors: Barresi
authors: P
authors: P
authors: Mellone
authors: G
authors: G
authors: Sinagra
authors: A
authors: A
authors: Dobrina
authors: F
authors: F
authors: De Giorgio
authors: R
authors: R
authors: Sharma
authors: F
authors: F
authors: Bassan
authors: A
authors: A
authors: Severino
authors: F
authors: F
authors: Baldi
authors: L M
authors: LM
authors: Biasucci
authors: F
authors: F
authors: Pandolfi
authors: F
authors: F
authors: Silvestri
authors: G W
authors: GW
authors: Vetrovec
authors: A
authors: A
authors: Baldi
authors: F
authors: F
authors: Crea
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001167:Arteritis / Q000473:pathology*; D001344:Autopsy; D003328:Coronary Thrombosis / Q000473:pathology*; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology*; D009205:Myocarditis / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology