title: A patient with gastric cancer and liver metastases successfully treated with combination chemotherapy including S-1.
abstract: We report the case of a 62-year-old man with advanced gastric cancer and multiple liver metastases who was successfully treated with combined chemotherapy including S-1. The patient was clinically diagnosed with stage IV (T3 N2 H1 P0) disease and was initially treated with 100 mg/body per day S-1 administered orally for 21 days and 10 mg/body per day cisplatin (CDDP) infused on days 1-5, 8-12, and 15-19. This chemotherapy resulted in significant reduction of the liver and gastric tumors. After receiving additional CDDP/S-1 administration as an outpatient, the patient's liver masses disappeared as shown on abdominal computed tomography (CT). With the patient's desire and informed consent, he underwent curative surgery with total gastrectomy, D1+alpha lymph node dissection, and partial resection of liver S4. After discharge without any surgical complication, CT revealed regrowth of the S4 liver mass, and combined docetaxel and CDDP was selected as second-line chemotherapy with local radiation therapy against the hepatic metastasis. Additionally, a third regimen with irinotecan and S-1 was given. At 2 years 7 months after the initial treatment, no sign of cancer (including liver metastasis and peritoneal dissemination) has been identified by radiological follow-up examinations.
authors: Department of Surgery, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors: Rieko
authors: R
authors: Nakamura
authors: Yoshiro
authors: Y
authors: Saikawa
authors: Koushi
authors: K
authors: Kumagai
authors: Tsuyoshi
authors: T
authors: Kiyota
authors: Masaki
authors: M
authors: Ohashi
authors: Masashi
authors: M
authors: Yoshida
authors: Tetsuro
authors: T
authors: Kubota
authors: Koichiro
authors: K
authors: Kumai
authors: Masaki
authors: M
authors: Kitajima
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004338:Drug Combinations; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D043823:Taxoids / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid; D002945:Cisplatin
references: Am J Surg. 2001 Mar;181(3):279-83
references: 11376587
references: Ann Oncol. 2003;14 Suppl 2:ii41-4
references: 12810457
references: Cancer Chemother Pharmacol. 1998;42(5):391-9
references: 9771954
references: Oncol Rep. 2002 Jan-Feb;9(1):89-92
references: 11748462
references: Gastric Cancer. 2003;6 Suppl 1:50-7
references: 12775021
references: J Clin Oncol. 2003 Jan 1;21(1):54-9
references: 12506170
references: Oncology. 2001;61(1):16-22
references: 11474243
references: Cancer Sci. 2004 Aug;95(8):679-84
references: 15298732
references: J Clin Oncol. 2000 Jul;18(14):2648-57
references: 10894863
references: Oncol Rep. 2003 Mar-Apr;10(2):381-6
references: 12579276
references: Surgery. 1993 Oct;114(4):799-805; discussion 804-5
references: 8211697
references: Oncol Rep. 2005 May;13(5):865-70
references: 15809751
references: Ann Surg Oncol. 1997 Apr-May;4(3):203-8
references: 9142380
references: Oncology. 1999 Oct;57(3):202-10
references: 10545788
references: Ann Surg. 2002 Jan;235(1):86-91
references: 11753046
references: Int J Clin Oncol. 2002 Oct;7(5):326-9
references: 12402069
references: Oncology. 2000 Apr;58(3):191-7
references: 10765119
references: Eur J Cancer. 2003 Nov;39(16):2328-33
references: 14556924
references: J Gastroenterol. 2000 Dec;35(12):907-11
references: 11573726
references: Oncology (Williston Park). 2002 May;16(5 Suppl 5):16-8
references: 12109800
references: Eur J Cancer. 1998 Oct;34(11):1715-20
references: 9893658
references: Br J Cancer. 2003 Dec 15;89(12):2207-12
references: 14676796
references: N Engl J Med. 2001 Sep 6;345(10):725-30
references: 11547741
references: J Clin Oncol. 1999 Jan;17 (1):319-23
references: 10458249
references: Oncology. 2000 Jun;59(1):14-7
references: 10895060
references: Oncol Rep. 2003 May-Jun;10 (3):687-91
references: 12684644