title: Fatty acid profile in milk from goats, Capra aegagrus hircus, exposed to perchlorate and its relationship with perchlorate residues in human milk.
abstract: Polyunsaturated fatty acids (PUFA) in milk are vital for normal growth and development of infant mammals. Changes in fatty acid composition were observed in milk fat from goats dosed with perchlorate (0.1 and 1 mg/kg body weight/day) for 31 days, but the effect was not persistent. Adaptation may be induced in these goats to compensate for the perchlorate effect. In an analysis of fatty acid composition in human milk samples, a weak negative correlation was observed between perchlorate concentrations and total PUFA in 38 human milk samples.
authors: Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409-1163, USA.
authors: Qiuqiong
authors: Q
authors: Cheng
authors: Ernest E
authors: EE
authors: Smith
authors: Andrea B
authors: AB
authors: Kirk
authors: Fujun
authors: F
authors: Liu
authors: Lee Mallory
authors: LM
authors: Boylan
authors: Michael E
authors: ME
authors: McCarty
authors: Sybil
authors: S
authors: Hart
authors: Linxia
authors: L
authors: Dong
authors: George P
authors: GP
authors: Cobb
authors: W Andrew
authors: WA
authors: Jackson
authors: Todd A
authors: TA
authors: Anderson
mesh_terms: D000818:Animals; D015992:Body Mass Index; D001942:Breast Feeding; D004305:Dose-Response Relationship, Drug; D005231:Fatty Acids, Unsaturated / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006041:Goats / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D010472:Perchlorates / Q000378:metabolism / Q000633:toxicity*; D011247:Pregnancy; D013997:Time Factors
chemical_list: D005231:Fatty Acids, Unsaturated; D010472:Perchlorates; C494474:perchlorate