Stem cell-mediated muscle regeneration and repair in aging and neuromuscular diseases.
One of the most exciting aspirations of current medical science is the regeneration of damaged body parts. The capacity of adult tissues to regenerate in response to injury stimuli represents an important homeostatic process that until recently was thought to be limited in mammals to tissues with high turnover such as blood and skin. However, it is now generally accepted that each tissue type, even those considered post-mitotic, such as nerve or muscle, contains a reserve of undifferentiated progenitor cells, loosely termed stem cells, participating in tissue regeneration and repair. Skeletal muscle regeneration is a coordinate process in which several factors are sequentially activated to maintain and preserve muscle structure and function upon injury stimuli. In this review, we will discuss the role of stem cells in muscle regeneration and repair and the critical role of specific factors, such as IGF-1, vasopressin and TNF-alpha, in the modulation of the myogenic program and in the regulation of muscle regeneration and homeostasis.
Musarò
A
A
Department of Histology and Medical Embryology, CE-BEMM and Interuniversity Institute of Myology, Sapienza University of Rome, Italy. antonio.musaro@uniroma1.it
Giacinti
C
C
Pelosi
L
L
Dobrowolny
G
G
Barberi
L
L
Nardis
C
C
Coletti
D
D
Scicchitano
B M
BM
Adamo
S
S
Molinaro
M
M
D000375:Aging / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D018482:Muscle, Skeletal / Q000502:physiology*; D009468:Neuromuscular Diseases / Q000503:physiopathology*; D012038:Regeneration; D013234:Stem Cells / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism
D014409:Tumor Necrosis Factor-alpha; D014667:Vasopressins; D007334:Insulin-Like Growth Factor I