Inhibitory effect of lactone fractions and individual components from three species of the Achillea millefolium complex of Bulgarian origin on the human neutrophils respiratory burst activity.
Achillea species are widely used in folk medicine for treatment of inflammatory diseases. The inhibitory effect on the human neutrophils respiratory burst activity of total extracts, their fractions and some main constituents of the flower heads from Achillea asplenifolia, A. collina and A. distans belonging to A. millefolium complex of Bulgarian origin, were tested by the modified method of Tan and Berridge. Seven from the investigated fractions showed activity similar or higher than that of indomethacine and might be evaluated as nonsteroidal anti-inflammatory agents.
Choudhary
Muhammad Iqbal
MI
H.E.J. Research Institute of Chemistry, International Center for Sciences, University of Karachi, Pakistan.
Jalil
Saima
S
Todorova
M
M
Trendafilova
A
A
Mikhova
B
B
Duddeck
H
H
Atta-ur-Rahman
D031162:Achillea / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002031:Bulgaria; D006801:Humans; D007213:Indomethacin / Q000493:pharmacokinetics / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008519:Medicine, Traditional; D009504:Neutrophils / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry*; D016897:Respiratory Burst
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D007213:Indomethacin