Relation of white matter anisotropy to visual memory in 17 healthy subjects.
We performed a Rey visual design learning test (RVDLT) in 17 subjects and measured intervoxel coherence (IC) by DTI as an indication of connectivity to investigate if visual memory performance would depend on white matter structure in healthy persons. IC considers the orientation of the adjacent voxels and has a better signal-to-noise ratio than the commonly used fractional anisotropy index. Voxel-based t-test analysis of the IC values was used to identify neighboring voxel clusters with significant differences between 7 low and 10 high test performers. We detected 9 circumscribed significant clusters (p< .01) with lower IC values in low performers than in high performers, with centers of gravity located in left and right superior temporal region, corpus callosum, left superior longitudinal fascicle, and left optic radiation. Using non-parametric correlation analysis, IC and memory performance were significantly correlated in each of the 9 clusters (r< .61 to r< .81; df=15, p< .01 to p< .0001). The findings provide in vivo evidence for the contribution of white matter structure to visual memory in healthy people.
Begré
Stefan
S
Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital Berne, University of Berne, Freiburgstrasse, CH-3010 Berne, Switzerland. stefan.begre@insel.ch
Frommer
Angela
A
von Känel
Roland
R
Kiefer
Claus
C
Federspiel
Andrea
A
D000293:Adolescent; D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods