Expression of heat shock proteins in myocardium of patients with atrial fibrillation.
Atrial fibrillation (AF) is the most common sustained arrhythmia. Because heat shock proteins (Hsp) can protect cells from stress, we compared the levels of Hsp60, Hsp72, Hsc73, and Hsp27 in atrial myocardium from 17 patients with AF (8 paroxysmal and 9 persistent) and 7 controls in sinus rhythm (SR). Hsp60, Hsp72, and Hsc73 levels were not significantly different among the 3 groups. Hsp27 expression was slightly higher in paroxysmal AF than in SR and in persistent AF, and a borderline significant difference (P = 0.064) was seen between the paroxysmal and persistent AF subgroups. Hsp60 levels in the moderate, severe, and profound myolysis groups were significantly lower than the light myolysis group, but no differences were found in other Hsps. In summary, the data indicate that expression of Hsp27 and Hsc73 may be associated with different stages of AF and that Hsp60 also may be associated with the degree of atrial myolysis.
Yang
Miao
M
Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, Hubei 430030, China.
Tan
Hao
H
Cheng
Longxian
L
He
Meian
M
Wei
Qingyi
Q
Tanguay
Robert M
RM
Wu
Tangchun
T
D000328:Adult; D000368:Aged; D001146:Arrhythmia, Sinus / Q000378:metabolism / Q000473:pathology; D020517:Atrial Appendage / Q000473:pathology; D001281:Atrial Fibrillation / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology*; D014019:Tissue Donors
D006360:Heat-Shock Proteins
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