Is PAMPA a useful tool for discovery?
Experimental PAMPA data generated for 40 low molecular weight commercial drugs is reviewed in the context of its utility in the drug discovery process. Several experimental variables that have been introduced in the literature as additions or improvements to the PAMPA were also evaluated. The relationship between PAMPA data and both calculated and measured octanol/water distribution coefficients was examined. From this assessment, it was concluded that the PAMPA yields information about the lipophilicity as measured by the octanol/water partitioning of a compound, but that this same information could be derived in a simpler manner from calculated log D values.
Galinis-Luciani
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Worldwide Drug Development, Cephalon, Inc., 145 Brandywine Parkway, West Chester, Pennsylvania 19380, USA. dluciani@cephalon.com
Nguyen
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Yazdanian
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D008567:Membranes, Artificial; D000442:Octanols / Q000737:chemistry; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010599:Pharmacokinetics; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
D008567:Membranes, Artificial; D000442:Octanols; D004364:Pharmaceutical Preparations; D014867:Water