Angiotensinogen gene polymorphism as a risk factor for ischemic stroke.
While gene polymorphism for angiotensinogen (AGT) is reported to contribute to the regulation of blood pressure and salt sensitivity, its effect on the risk of ischemic stroke remains controversial. We hypothesized that polymorphism of the AGT gene could be a risk factor for ischemic stroke. Major clinical risk factors and the AGT gene M235T polymorphism were examined in 147 consecutive stroke patients and 133 healthy age-matched controls. All patients were categorized into four stroke types (single lacuna, multiple lacunae, large-artery atherosclerosis and branch atheromatous disease in brainstem) and two vascular groups (large and perforating arterial lesions). The AGT gene M allele significantly increased the risk of single lacuna, multiple lacunae and small arterial lesions, in male patients (p=0.029, 0.031 and 0.026, respectively). Synergistic effects of the AGT gene polymorphism and clinical risks were not observed. In conclusion, AGT M allele may present a risk of lacunar infarctions in Japanese men, independent of hypertension.
Nakase
Taizen
T
Department of Neurology, Research Institute for Brain and Blood Vessels, 6-10 Senshu Kubota Machi, Akita, Japan 010-0874. nakase@akita-noken.go.jp
Mizuno
Toshiki
T
Harada
Sanae
S
Yamada
Kei
K
Nishimura
Tsunehiko
T
Ozasa
Kotaro
K
Watanabe
Yoshiyuki
Y
Nagata
Ken
K
D000368:Aged; D000369:Aged, 80 and over; D000808:Angiotensinogen / Q000235:genetics*; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D020520:Brain Infarction / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D002545:Brain Ischemia / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D002536:Cerebral Arteries / Q000378:metabolism / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D007564:Japan / Q000453:epidemiology / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012727:Sex Characteristics; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*
D005819:Genetic Markers; D000808:Angiotensinogen