Longitudinal study of serum lipids and liver enzymes in workers with occupational exposure to ammonium perfluorooctanoate.
OBJECTIVE
To examine the relationship between serum perfluorooctanoate (PFOA), a biomarker of ammonium perfluorooctanoate exposure, and lipids and liver enzymes.


METHODS
We conducted a longitudinal study on 454 workers and used mixed models to examine the relationship between serum PFOA and lipids and liver enzymes.


RESULTS
One part per million (ppm) increase in serum PFOA was associated with a 1.06 mg/dL increase in total cholesterol, but was not associated with changes in triglycerides or other lipoproteins, after adjusting for potential confounders. Serum PFOA was also associated with total bilirubin (0.008 mg/dL decline/ppm) and serum aspartate aminotransferase (0.35 units increase/ppm) but not with the other liver enzymes.


CONCLUSIONS
These medical surveillance data collected on workers for up to 25 years contributes useful information on the effects of ammonium perfluorooctanoate exposure on human liver and lipid chemistry.
Sakr
Carine J
CJ
Yale University School of Medicine, New Haven, Connecticut, USA. carine.sakr@yale.edu
Leonard
Robin C
RC
Kreckmann
Kim H
KH
Slade
Martin D
MD
Cullen
Mark R
MR
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002210:Caprylates / Q000009:adverse effects* / Q000097:blood*; D002617:Chemical Industry; D002784:Cholesterol / Q000097:blood; D005260:Female; D005466:Fluorocarbons / Q000009:adverse effects* / Q000097:blood*; D006801:Humans; D008111:Liver Function Tests; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D002210:Caprylates; D005466:Fluorocarbons; D014280:Triglycerides; C023036:perfluorooctanoic acid; D002784:Cholesterol