title: An unusual cause of mastoiditis that evolved into multiple ring-enhancing intracerebral lesions in a person with HIV infection.
abstract: Acute mastoiditis, an infectious inflammatory process in the temporal bone, is an uncommon complication of otitis media. Here we describe a fatal case of mastoiditis complicated by thrombosis of the sigmoid sinus and intracerebral abscess caused by an unusual pathogen (Nocardia asteroides) in a person with HIV infection. Sulfonamides have remained the first-line agents for the management of Nocardia infections, but mortality remains high in patients with intracerebral infection.
authors: Jackson Memorial Hospital, Miami, Florida, USA.
authors: Sabina
authors: S
authors: Casula
authors: José G
authors: JG
authors: Castro
authors: Luis A
authors: LA
authors: Espinoza
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D000328:Adult; D001922:Brain Abscess / Q000382:microbiology*; D003392:Cranial Sinuses / Q000473:pathology; D017809:Fatal Outcome; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D006257:Head / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008417:Mastoiditis / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D009616:Nocardia asteroides / Q000302:isolation & purification; D011859:Radiography; D012851:Sinus Thrombosis, Intracranial