Microbial transformation of neoandrographolide by Aspergillus niger (AS 3.739).
The biotransformation of neoandrographolide (1) was investigated by using Aspergillus niger (AS 3.739). Five products were obtained and identified as 8(17),13-ent-labdadien-16,15-olid-19-oic acid (2), 19-hydroxy-8(17),13-ent-labdadien-16,15-olide (3), 18-hydroxy-8(17),13-ent-labdadien-16,15-olid-19-oic acid (4), 3alpha-hydroxy-8(17),13-ent-labdadien-16,15-olid-19-oic acid (5) and 8beta,19-dihydroxy-ent-labd-13-en-16,15-olide (6) by spectroscopic and chemical means. Products 4, 5 and 6 are new compounds.
Chen
Li-Xia
LX
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
Qiu
Feng
F
Qu
Ge-Xia
GX
Yao
Xin-Sheng
XS
D001234:Aspergillus niger / Q000378:metabolism*; D001711:Biotransformation; D004224:Diterpenes; D005960:Glucosides / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000378:metabolism*
D004224:Diterpenes; D005960:Glucosides; D013764:Tetrahydronaphthalenes; C082497:neoandrographolide