title: Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.
abstract: Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously described inhibition of Brucella HDH activity.
authors: Centre d'Etudes d'Agents Pathogènes et Biotechnologies pour la Santé (CPBS), CNRS-UM1-UM2, UMR 5236, Université Montpellier II, cc100, Place Eugène Bataillon, 34095, Montpellier Cedex, France. pjoseph@univ-montp2.fr
authors: Pascale
authors: P
authors: Joseph
authors: Marie-Rose
authors: MR
authors: Abdo
authors: Rose-Anne
authors: RA
authors: Boigegrain
authors: Jean-Louis
authors: JL
authors: Montero
authors: Jean-Yves
authors: JY
authors: Winum
authors: Stephan
authors: S
authors: Köhler
mesh_terms: D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D041021:Brucella suis / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D002006:Brucellosis / Q000382:microbiology; D002460:Cell Line; D003470:Culture Media; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006639:Histidine / Q000494:pharmacology; D006641:Histidinol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D007659:Ketones / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology*; D013329:Structure-Activity Relationship; D037521:Virulence Factors / Q000037:antagonists & inhibitors*
chemical_list: D003470:Culture Media; D004791:Enzyme Inhibitors; D007659:Ketones; D037521:Virulence Factors; D006639:Histidine; D006641:Histidinol; D000429:Alcohol Oxidoreductases; C021358:histidinol dehydrogenase
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