title: Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens.
abstract: Mutation of the HMG-CoA synthase encoding mupH gene in Pseudomonas fluorescens gives rise to a new metabolite formed from a truncated polyketide intermediate, providing in vivo evidence for the roles of mupH and cognate genes found in several "AT-less" and other bacterial PKS gene clusters responsible for the biosynthesis of diverse metabolites containing acetate/propionate derived side chains.
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK.
authors: Ji'en
authors: J
authors: Wu
authors: Sian M
authors: SM
authors: Cooper
authors: Russell J
authors: RJ
authors: Cox
authors: John
authors: J
authors: Crosby
authors: Matthew P
authors: MP
authors: Crump
authors: Joanne
authors: J
authors: Hothersall
authors: Thomas J
authors: TJ
authors: Simpson
authors: Christopher M
authors: CM
authors: Thomas
authors: Christine L
authors: CL
authors: Willis
mesh_terms: D002384:Catalysis; D006904:Hydroxymethylglutaryl-CoA Synthase / Q000235:genetics / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D005810:Multigene Family / Q000235:genetics; D016712:Mupirocin / Q000096:biosynthesis* / Q000737:chemistry*; D009154:Mutation / Q000235:genetics; D048630:Polyketide Synthases / Q000378:metabolism; D011551:Pseudomonas fluorescens / Q000201:enzymology*
chemical_list: D048630:Polyketide Synthases; D016712:Mupirocin; D006904:Hydroxymethylglutaryl-CoA Synthase