A phyllodes tumor of the urinary bladder in a rat.
OBJECTIVE
The aim of this short communication was to describe a case of phyllodes tumor of the urinary bladder discovered in a female Fisher 344 rat that died during an experimental protocol to induce and study urothelial lesions by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN).


METHODS
From a group of several female rats exposed to BBN via drinking water over the course of 20 weeks, one animal died. At necropsy, a solid mass was identified in the urinary bladder lumen, with a diameter of 0.8 x 0.7 cm. This tumor was processed for histopathological examination and Feulgen coloration.


RESULTS
Microscopically, the mass in the bladder was observed to be a phyllodes tumor. DNA content measured by image analysis of a Feulgen-stained section of the tumor and stroma cells displayed diploid DNA content in both components of the tumor.


CONCLUSIONS
This is the first reported phyllodes tumor in a rat's urinary bladder. The exact prognosis and histogenesis of phyllodes tumors of the urinary bladder remains to be determined by the accumulation of data from additional cases.
Oliveira
P A
PA
Department of Veterinary Sciences, CECAV, University of Tras-os-Montes e Alto Douro, 5001-801, Vila Real, Portugal. pamo@utad.pt
Colaco
A A
AA
Palmeira
C A
CA
De la Cruz P
L F
LF
Lopes
C A
CA
D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity; D002471:Cell Transformation, Neoplastic; D004396:Coloring Agents / Q000378:metabolism; D004273:DNA, Neoplasm / Q000032:analysis; D004801:Eosine Yellowish-(YS) / Q000378:metabolism; D005260:Female; D006416:Hematoxylin / Q000378:metabolism; D003557:Phyllodes Tumor / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D011916:Rats, Inbred F344; D012394:Rosaniline Dyes / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000473:pathology*
D002273:Carcinogens; D004396:Coloring Agents; D004273:DNA, Neoplasm; C007722:Feulgen stain; D012394:Rosaniline Dyes; D002085:Butylhydroxybutylnitrosamine; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin