title: In-line liquid-phase microextraction for selective enrichment and direct electrophoretic analysis of acidic drugs.
abstract: This work describes an efficient in-line extraction-preconcentration unit coupled to the electrophoretic capillary based on a liquid-phase microextraction (LPME) process, which can be directly assembled to the cartridge of the commercial CE equipment. The unit permits analyte extraction, preconcentration and electrophoretic separation to be automatically performed in the commercial CE equipment without the need for additional hardware or software. This new approach was usefully used for the separation and determination of nonsteroidal anti-inflammatory drugs in human urine permitting at least to analyze 30 consecutive real samples. The LODs were lower than 2 microg/L and the reproducibility, expressed as RSD, was 3.1% for the same unit and only 4.8% between different units.
authors: Department of Analytical Chemistry, University of Córdoba, Campus de Rabanales, Córdoba, Spain.
authors: Leonor
authors: L
authors: Nozal
authors: Lourdes
authors: L
authors: Arce
authors: Bartolomé M
authors: BM
authors: Simonet
authors: Angel
authors: A
authors: Ríos
authors: Miguel
authors: M
authors: Valcárcel
mesh_terms: D000143:Acids / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis*
chemical_list: D000143:Acids; D004364:Pharmaceutical Preparations