Myxoinflammatory fibroblastic sarcoma: investigations by comparative genomic hybridization of two cases and review of the literature.
Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade sarcoma of the distal extremities characterized by a myxohyaline stroma, a dense inflammatory infiltrate and virocyte- and lipoblast-like giant cells. Up to now, only two cases have been investigated cytogenetically, showing complex and heterogeneous karyotypes, in part with supernumerary ring chromosomes. We characterized two further cases of MIFS immunohistochemically and performed comparative genomic hybridization as well as DNA image cytometry analyses. Both tumors showed the characteristic histomorphological pattern of MIFS and were positive for Vimentin and CD68. Moreover, both cases presented aberrant karyotypes including distinct DNA copy number changes involving chromosome 7 and disclosed DNA aneuploidy.
Baumhoer
Daniel
D
Institute of Pathology, University of Basel, Schönbeinstrasse 40, 4003 Basel, Switzerland. dbaumhoer@mac.com
Glatz
Kathrin
K
Schulten
Hans-Jürgen
HJ
Füzesi
László
L
Fricker
Renato
R
Kettelhack
Christoph
C
Hasenboehler
Paula
P
Oberholzer
Martin
M
Jundt
Gernot
G
D000368:Aged; D005260:Female; D005385:Fingers; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009693:Nucleic Acid Hybridization; D012516:Osteosarcoma / Q000235:genetics* / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000235:genetics* / Q000473:pathology; D020429:Tibial Neuropathy / Q000235:genetics* / Q000473:pathology
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