[Effect of p53 gene knockout on cell migration].
OBJECTIVE
To investigate the role of p53 gene in serum-induced cell migration.


METHODS
The effects of p53 knockout on serum-induced formation of lamellipodia and cell migration were observed using Transwell cell migration system.


RESULTS
p53(+/+) cells developed lamellipodia upon serum stimulation and showed enhanced activity of cell migration, but these effects were not observed in p53 knockout cells after serum stimulation.


CONCLUSIONS
p53 plays a role in serum-induced cell migration.
Gong
Xiao-Wei
XW
Department of Pathophysiology and Key Laboratory of Proteomics of Gongdong Province, Southern Medical University, Guangzhou 510515, China.
Wei
Jie
J
Li
Yu-Sheng
YS
Cheng
Wei-Wei
WW
Wang
Xu
X
Deng
Peng
P
Jiang
Yong
Y
D000818:Animals; D002460:Cell Line; D002465:Cell Movement / Q000235:genetics*; D005786:Gene Expression Regulation; D055786:Gene Knockout Techniques; D051379:Mice; D011554:Pseudopodia / Q000235:genetics / Q000378:metabolism; D044967:Serum / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency* / Q000235:genetics* / Q000378:metabolism
D016159:Tumor Suppressor Protein p53