[Synchronization analysis of ECoG and EHG from eplieptiform discharges rats].
The mechanisms leading to the occurrence of seizures in humans are still poorly understood. It is widely accepted, however, that the process of seizure generation is closely associated with an abnormal synchronization of neurons. In order to investigate this process, we have studied synchronization between different regions of the brain from intracranial EEG recordings of Pilocarpine-induced epileptic rat by Synchronization likelihood (SL). It was found that during the state of transition from non-epileptiform discharges to continuous-epileptiform discharges, synchronization between left-ECoG and left-EHG was significantly strengthened, and similar change had taken place between right-ECoG and right-EHGd; left-ECoG; and right-ECoG and left-EHG and right-EHG (P < 0.05). During the state of transition from continuous-epileptiform discharges to period-epileptiform discharges, the synchronization was significantly weakened between left-ECoG and left-EHG, and similar change was noted between left-EHG and right-EHG (P < 0.01). The results showed that SL might be used to assess the dynamics of synchronization and it might be helpful to understanding the mechanisms involving the origin of epileptiform discharge.
Liu
Yansu
Y
School of Life Science and Technology, UESTC, Chengdu 610054 China.
Xia
Yang
Y
Wu
Hongyi
H
Lai
Yongxiu
Y
Yao
Dezhong
D
D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D006624:Hippocampus / Q000503:physiopathology*; D008297:Male; D010862:Pilocarpine; D051381:Rats; D017207:Rats, Sprague-Dawley; D012815:Signal Processing, Computer-Assisted
D010862:Pilocarpine