title: A novel antiplasmodial 3',5'-diformylchalcone and other constituents of Friesodielsia obovata.
abstract: Phytochemical investigation of the stem and root barks of Friesodielsia obovata Benth (Annonaceae) afforded new 3',5'-diformyl-2',4',6'-trihydroxychalcone and N-formyl-7-hydroxyglaucine together with five known compounds, 3',5'-dimethyl-2',4',6'-trihydroxychalcone, (-)-crotepoxide, demethoxymatteucinol, lawinal, and benzyl benzoate. 3',5'-diformyl-2',4',6'-trihydroxychalcone indicated significant antiplasmodial, cytotoxicity, and larvicidal activities.
authors: Department of Chemistry, University of Dar es Salaam, Dar es Salaam, Tanzania. cosam@chem.udsm.ac.tz
authors: Cosam C
authors: CC
authors: Joseph
authors: Joseph J
authors: JJ
authors: Magadula
authors: Mayunga H H
authors: MH
authors: Nkunya
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000852:Anopheles / Q000187:drug effects; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013636:Tanzania
chemical_list: C523927:3',5'-diformylchalcone; D000962:Antimalarials; D047188:Chalcones