title: Endoplasmicreticulum-induced signal transduction and gene expression.
abstract: Cells can respond to perturbations in endoplasmic reticulum (ER) function by activating two distinct signal-transduction pathways: one responds to unfolded proteins, the other to an overload of the organelle with membrane proteins. A third pathway is activated upon sterol depletion of cells and involves the cleavage and subsequent nuclear translocation of an ER membrane-bound transcription factor. Thus, three distinct pathways each activated by a different signal are currently known to project from the ER into the nucleus. This review summarizes the current understanding of these three pathways.
authors: The Institute for Experimental Cancer Research, Tumor Biology Center, PO Box 1120, D-79106 Freiburg, Germany.
authors: H L
authors: HL
authors: Pahl
authors: P A
authors: PA
authors: Baeuerle