Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.
Köhler
Karen
K
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, Germany.
Hillebrecht
Alexander
A
Schulze Wischeler
Johannes
J
Innocenti
Alessio
A
Heine
Andreas
A
Supuran
Claudiu T
CT
Klebe
Gerhard
G
D000818:Animals; D001665:Binding Sites; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D008670:Metals; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D012439:Saccharin / Q000737:chemistry* / Q000494:pharmacology*; D013649:Taste
D002257:Carbonic Anhydrase Inhibitors; D007527:Isoenzymes; D008670:Metals; D002256:Carbonic Anhydrases; D012439:Saccharin