Clinicopathologic significance in serum presence of anti-p53 antibody in patients with colorectal carcinoma.
OBJECTIVE
Alteration of p53 gene links to the appearance and detection of anti-p53 antibodies in the serum. The aim of this study is to find the clinicopathologic significance for serum presence of anti-p53 antibodies in patients with colorectal carcinoma.


METHODS
Serum presence of anti-p53 antibodies was examined for sera of 36 patients with colorectal carcinoma using enzyme-linked immunosorbent assay.


RESULTS
Frequency of serum presence of anti-p53 antibodies was 47.2% (17 of 36). Incidence of lymph node metastasis and lymphatic invasion in tumors coexisting with serum presence of anti-p53 antibodies (70.6%, 12 of 17 and 94.1%, 16 of 17) were significantly higher than those in tumors without serum presence of anti-p53 antibodies (17.6%, 3 of 17 and 68.4%, 13 of 19; p = 0.007 and p = 0.041, respectively). Stages of the tumors were significantly more advanced in carcinomas coexisting with serum presence of anti-p53 antibodies (p = 0.023). Frequency in serum presence of anti-p53 antibodies among patients with tumors expressing p53 (73.7%, 14 of 19) was significantly higher than that among patients with tumors without p53 expression (17.6%, 3 of 17; p = 0.0005).


CONCLUSIONS
Preoperative serum appearance of anti-53 antibodies can be an indicator for more malignant potential of colorectal carcinoma.
Nozoe
Tadahiro
T
Department of General Surgery, Fukuoka Dental College Hospital Kyushu University 2-15-1, Tamura, Sawara Ward, Fukuoka, 814-0193, Japan. ntvb@med.uoeh-u.ac.jp
Yasuda
Mitsuhiro
M
Honda
Masayuki
M
Inutsuka
Sadaaki
S
Korenaga
Daisuke
D
D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*
D001323:Autoantibodies; D016159:Tumor Suppressor Protein p53