title: Distribution of intraductal lesions in small invasive ductal carcinoma of the pancreas.
abstract: OBJECTIVE
  To investigate the distribution of intraductal lesions in small invasive ductal carcinoma (IDC) of the pancreas.
  
  
  METHODS
  In 21 cases with IDCs microscopically < or = 20 mm in diameter, the intraductal lesions around a mass were studied histologically and mapped according to the pancreatic intraepithelial neoplasia (PanIN) classification.
  
  
  RESULTS
  PanIN-3, PanIN-2, PanIN-1B and PanIN-1A were found in 17, 10, 20 and 21 of 21 cases, respectively, and were divided into lesions in adjacent and distal areas, respectively defined as within and beyond 10 mm from the mass as follows: 100% (17/17), 100% (10/10), 95.0% (19/20) and 90.5% (19/21) in the former, while 23.5% (4/17), 50.0% (5/10), 90.0% (18/20) and 95.2% (20/21) in the latter. PanIN-3 lesions were predominantly found in the area adjacent to the mass. In some cases, significant PanIN-3 appeared to show a consecutive geographic extension around the mass via the main pancreatic duct (MPD). The distance of PanIN-3 spread was within 25 (mean 10.5) mm from the mass edge. PanIN-2 lesions were found in the area adjacent to the mass and discontinuous with the mass or PanIN-3 lesions. PanIN-1B and PanIN-1A tended mainly to exist sporadically throughout the entire pancreas. In the MPD, PanIN-3 was found in 14 (82.4%) of 17 cases and in 36 (32.1%) of 112 lesions, which was most frequent in intraductal lesions.
  
  
  CONCLUSIONS
  PanIN-3 lesions might be an intraductal extension of the main tumor. The resection margin of 25 mm, at least longer than 11 mm, from the mass edge will be necessary.
authors: Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan. thisa@r8.dion.ne.jp
authors: Takeshi
authors: T
authors: Hisa
authors: Koichi
authors: K
authors: Suda
authors: Bunsei
authors: B
authors: Nobukawa
authors: Hiroki
authors: H
authors: Ohkubo
authors: Satoshi
authors: S
authors: Shiozawa
authors: Hiroki
authors: H
authors: Ishigame
authors: Kenji
authors: K
authors: Yamao
authors: Yasushi
authors: Y
authors: Yatabe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000473:pathology*