The effect of neurodegenerative diseases on the subventricular zone.
During brain development, one of the most important structures is the subventricular zone (SVZ), from which most neurons are generated. In adulthood the SVZ maintains a pool of progenitor cells that continuously replace neurons in the olfactory bulb. Neurodegenerative diseases induce a substantial upregulation or downregulation of SVZ progenitor cell proliferation, depending on the type of disorder. Far from being a dormant layer, the SVZ responds to neurodegenerative disease in a way that makes it a potential target for therapeutic intervention.
Curtis
Maurice A
MA
Institute of Neuroscience and Physiology at Sahlgrenska Academy, Medicinaregat 11, Box 432, s-40530 Göteborg, Sweden. maurice.curtis@neuro.gu.se
Faull
Richard L M
RL
Eriksson
Peter S
PS
D000818:Animals; D006801:Humans; D020547:Lateral Ventricles / Q000473:pathology* / Q000503:physiopathology*; D019636:Neurodegenerative Diseases / Q000473:pathology* / Q000503:physiopathology; D009474:Neurons / Q000473:pathology / Q000502:physiology*