title: Protein dynamics and function: insights from the energy landscape and solvent slaving.
abstract: Protein motions are complex and a good way to describe them is in terms of a very high-dimensional conformation space. We give here a simple explanation of the conformation space and the energy landscape, the conformational motions and protein reactions, based on an analogy to a traffic problem. The analogy provides insight into the slaving of protein processes to bulk solvent fluctuations, in both the native and unfolded states.
authors: Theory Division, K710, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA. frauenfelder@lanl.gov
authors: Hans
authors: H
authors: Frauenfelder
authors: Paul W
authors: PW
authors: Fenimore
authors: Robert D
authors: RD
authors: Young
mesh_terms: D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D011506:Proteins; D012997:Solvents