Retinopathy of prematurity in Asian Indian babies weighing greater than 1250 grams at birth: ten year data from a tertiary care center in a developing country.
BACKGROUND
Retinopathy of prematurity (ROP) is an important cause of childhood blindness in developing countries.


OBJECTIVE
To report the spectrum of ROP and associated risk factors in babies weighing > 1250 g at birth in a developing country.


METHODS
Institutional, retrospective, non-randomized, observational clinical case series.


METHODS
Retrospective analysis (10 years) of 275 eyes (138 babies) with ROP.


METHODS
Qualitative data with the Chi-square test. Quantitative data using the unpaired t test or the ANOVA and further tested using multivariate logistic regression.


RESULTS
The mean birth weight was 1533.9 g (range 1251 to 2750 g) and the mean period of gestation was 30.9 weeks (range 26 to 35). One hundred and twenty-four of 275 eyes (45.1%) had threshold or worse ROP. Risk factors for threshold or worse disease were, 'outborn babies' ( P P = 0.007) and exchange transfusion ( P = 0.003). The sensitivity of the American and British screening guidelines to pick up threshold or worse ROP in our study group was 82.4% and 77.4% respectively.


CONCLUSIONS
Severe ROP is often encountered in babies weighing greater than 1250 g at birth in developing countries. Western screening guidelines may require modifications before application in developing countries.
Vinekar
Anand
A
Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Dogra
Mangat R
MR
Sangtam
Tiakumzuk
T
Narang
Anil
A
Gupta
Amod
A
D044466:Asian People; D005500:Follow-Up Studies; D006764:Hospitals, Community / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D015999:Multivariate Analysis; D012178:Retinopathy of Prematurity / Q000208:ethnology*; D012189:Retrospective Studies; D012307:Risk Factors
Br J Ophthalmol. 1998 Jan;82(1):1-2
9536867
Eye (Lond). 1997;11 ( Pt 4):509-14
9425417
Pediatrics. 1998 Jul;102(1 Pt 1):31-4
9651410
Indian J Ophthalmol. 1998 Mar;46(1):15-9
9707842
Pediatrics. 2005 May;115(5):e518-25
15805336
Indian J Ophthalmol. 2001 Jun;49(2):97-101
15884513
Indian J Ophthalmol. 2005 Dec;53(4):261-5
16333175
Pediatrics. 2006 Feb;117(2):572-6
16452383
Br J Ophthalmol. 2006 Mar;90(3):268-71
16488941
Am J Ophthalmol. 2006 May;141(5):966-8
16678524
Br J Ophthalmol. 2001 Sep;85(9):1017-9
11520743
Br J Ophthalmol. 2002 Oct;86(10):1072-3
12234879
Br J Ophthalmol. 2002 Oct;86(10):1127-30
12234892
J AAPOS. 2003 Jun;7(3):190-4
12825059
J Pediatr Ophthalmol Strabismus. 2003 Jul-Aug;40(4):193
12908528
J Pediatr Ophthalmol Strabismus. 2003 Jul-Aug;40(4):208-12
12908532
Jpn J Ophthalmol. 2004 Jan-Feb;48(1):50-3
14767651
Ophthalmology. 2004 Jul;111(7):1317-25
15234131
Indian Pediatr. 2004 Jul;41(7):665-71
15297681
Arch Ophthalmol. 1984 Aug;102(8):1130-4
6547831
Arch Ophthalmol. 1990 Feb;108(2):195-204
2405827
Acta Paediatr Scand. 1990 Oct;79(10):906-10
2264462
Ophthalmology. 1991 Jan;98(1):14-7
2023725
Eye (Lond). 1991;5 ( Pt 1):80-5
2060677
Eye (Lond). 1992;6 ( Pt 3):233-42
1446754
J Paediatr Child Health. 1995 Apr;31(2):134-6
7794615
Indian J Ophthalmol. 1995 Jun;43(2):59-61
8818311
Indian J Ophthalmol. 1995 Sep;43(3):123-6
8822486
Early Hum Dev. 1996 Nov 21;46(3):239-58
8922568
Br J Ophthalmol. 1996 Aug;80(8):728-31
8949718
Indian Pediatr. 1996 Dec;33(12):999-1003
9141799
Arch Ophthalmol. 1998 May;116(5):608-12
9596496
Lancet. 1997 Jul 5;350(9070):12-4
9217713