Living with p53, dying of p53.
The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this issue of Cell, Das et al. (2007) and Tanaka et al. (2007) provide new insights into the mechanisms that dictate the life and death decisions of p53.
Aylon
Yael
Y
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Oren
Moshe
M
D017209:Apoptosis / Q000235:genetics* / Q000502:physiology; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D016923:Cell Death / Q000235:genetics / Q000502:physiology; D004249:DNA Damage; D004268:DNA-Binding Proteins; D015972:Gene Expression Regulation, Neoplastic; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics; D011485:Protein Binding; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000502:physiology*
D004268:DNA-Binding Proteins; D016159:Tumor Suppressor Protein p53