title: Valvular cardiac myxoma in a dog.
abstract: Primary and secondary cardiac tumours are extremely rare in humans and domestic animals. This case describes the gross, light microscopical and immunohistochemical examination of a cardiac myxoma arising from the tricuspid valve in a 13-year-old female terrier dog. Clinically, long-term respiratory distress, progressive ascites, fatigue and exercise intolerance were observed in the animal. At necropsy, the right ventricular chamber was mildly dilated and a soft, whitish mass, 0.7 x 1.5 x 2.1 cm in size was observed arising from the ventricular surface of the septal leaflet of the tricuspid valve of the heart. Histologically, the mass was composed of a faintly eosinophilic myxoid matrix and spindle shaped fibroblast-like cells with elongated nuclei and stellate cells. The extracellular matrix was stained with periodic acid Schiff and alcian blue and the tumour cells were reactive with anti-vimentin and anti-alpha-sarcomeric actin antibodies. The authors believe that this is the first detailed description of a myxoma in this breed.
authors: Department of Pathology, Faculty of Veterinary Medicine, Uludag University, 16059, Gorukle, Bursa, Turkey. aakkoc@uludag.edu.tr
authors: A
authors: A
authors: Akkoc
authors: M O
authors: MO
authors: Ozyigit
authors: I T
authors: IT
authors: Cangul
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006338:Heart Neoplasms / Q000473:pathology / Q000662:veterinary*; D006349:Heart Valve Diseases / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D009232:Myxoma / Q000473:pathology / Q000662:veterinary*