title: Twin pregnancy with a coexisting hydatiform mole and liveborn infant: complicated by maternal hyperthyroidism and neonatal hypothyroidism.
abstract: A twin pregnancy with a coexisting complete hydatiform mole and a healthy fetus is rare. Associated with this condition are potentially serious maternal and fetal complications. We describe a case of a woman, 23/40 pregnant, who was diagnosed with a twin pregnancy complicated by a hydatiform mole, vaginal bleeding, hyperthyroidism and preterm labour at 26/40. Her hyperthyroidism was successfully treated with propylthiouracil. The preterm labour resulted in the livebirth of a healthy male infant. The baby developed biochemical hypothyroidism post-natally. The baby's thyroid function tests were unexpected, revealing a low T4 and a low-normal thyroid stimulating hormone. This is the first case reported in the literature to describe an infant's clinical and biochemical thyroid status after gestational trophoblastic disease complicated by hyperthyroidism.
authors: Department of Paediatric Endocrinology, Mater Children's Hospital, Brisbane, Queensland, Australia. truenaidu@optusnet.com.au
authors: Deanna K
authors: DK
authors: True
authors: Michael
authors: M
authors: Thomsett
authors: Helen
authors: H
authors: Liley
authors: Sridhar
authors: S
authors: Chitturi
authors: Robert
authors: R
authors: Cincotta
authors: Adam
authors: A
authors: Morton
authors: Andrew
authors: A
authors: Cotterill
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole; D006980:Hyperthyroidism / Q000097:blood / Q000188:drug therapy*; D007037:Hypothyroidism / Q000097:blood / Q000150:complications*; D007231:Infant, Newborn; D050498:Live Birth; D008297:Male; D011247:Pregnancy; D011433:Propranolol / Q000627:therapeutic use; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use; D013960:Thyroid Function Tests; D016896:Treatment Outcome; D014427:Twins
chemical_list: D000319:Adrenergic beta-Antagonists; D013956:Antithyroid Agents; D011441:Propylthiouracil; D011433:Propranolol