Polymorphism of the vWA locus located in the center of the three vWA STRs in the Japanese population.
The structural polymorphism of the vWA locus (vWA-T) located between the two polymorphic vWA loci (vWA-K and -P) was analyzed in 100 Japanese individuals using DNA samples isolated from dental pulp. The polymorphism of this locus was based on the difference in the number of tcta repeat. New interallele 11.1 was found in two samples. All together 9 alleles and 19 genotypes were observed. In addition, one mutant allele contained tcga in the common tcta repeat structure. The value of PD was calculated to be 0.900. Inheritance of the polymorphism was confirmed in a family including 23 individuals and 6 matings.
Tsutsumi
Hirofumi
H
Department of Legal Medicine, Nihon University School of Dentistry, Tokyo 101-8310, Japan.
Komuro
Toshinobu
T
Mukoyama
Rei
R
Nogami
Hiroaki
H
D044466:Asian People / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007564:Japan; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences; D014841:von Willebrand Factor / Q000235:genetics*
D014841:von Willebrand Factor