title: Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
abstract: The host-parasite relationship is based on a series of interplays between host defense mechanisms and parasite survival strategies. Progress has been made in understanding the role of host immune response in amebiasis. While host cells elaborate diverse mechanisms for pathogen expulsion, amebae have also developed complex strategies to modulate host immune response and facilitate their own survival. This paper will give an overview of current research on the mutual interactions between host and Entamoeba histolytica in human and experimental amebiasis. Understanding this crosstalk is crucial for the effective design and implementation of new vaccines and drugs for this leading parasitic disease.
authors: Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908-1340, USA.
authors: Xiaoti
authors: X
authors: Guo
authors: Eric
authors: E
authors: Houpt
authors: William A
authors: WA
authors: Petri
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology; D004748:Entamoeba histolytica / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology; D004749:Entamoebiasis / Q000276:immunology* / Q000469:parasitology; D006790:Host-Parasite Interactions; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology / Q000469:parasitology
chemical_list: D000913:Antibodies, Protozoan
references: Crit Rev Immunol. 1995;15(2):107-31
references: 8573284
references: Gastroenterology. 2006 Mar;130(3):721-30
references: 16530514
references: Immunology. 1993 Feb;78(2):291-7
references: 8386134
references: Mol Biochem Parasitol. 2005 Sep;143(1):80-9
references: 15996766
references: Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13561-6
references: 14585927
references: Gut. 1996 Oct;39(4):521-7
references: 8944559
references: J Leukoc Biol. 1989 Sep;46(3):270-4
references: 2547889
references: FASEB J. 2004 Jan;18(1):155-7
references: 14630697
references: Exp Parasitol. 2002 May;101(1):40-56
references: 12243737
references: J Immunol. 2002 Oct 15;169(8):4496-503
references: 12370386
references: J Biol Chem. 2006 Sep 8;281(36):26112-20
references: 16840786
references: Nat Immunol. 2002 Nov;3(11):1041-7
references: 12407413
references: Am J Pathol. 1984 Oct;117(1):71-80
references: 6385727
references: Biochem J. 2000 Sep 15;350 Pt 3:805-14
references: 10970796
references: J Immunol. 1986 Apr 1;136(7):2633-9
references: 2869086
references: Korean J Parasitol. 1993 Sep;31(3):239-48
references: 8241083
references: Infect Immun. 2006 Jan;74(1):118-24
references: 16368964
references: FASEB J. 2006 Dec;20(14):2460-7
references: 17142795
references: J Immunol. 2006 Jul 15;177(2):1208-13
references: 16818779
references: Immunology. 1995 Sep;86(1):49-57
references: 7590881
references: Infect Immun. 1999 Aug;67(8):3836-41
references: 10417146
references: J Immunol. 2005 Apr 1;174(7):4279-88
references: 15778391
references: Arch Invest Med (Mex). 1990;21 Suppl 1:57-61
references: 2136504
references: Infect Immun. 1995 Oct;63(10):3953-8
references: 7558304
references: J Clin Invest. 1995 Sep;96(3):1269-79
references: 7657801
references: Infect Immun. 2006 Feb;74(2):904-9
references: 16428733
references: Am J Trop Med Hyg. 1994 Oct;51(4):454-9
references: 7943572
references: Gastroenterology. 2005 Jul;129(1):142-55
references: 16012944
references: Infect Immun. 1999 May;67(5):2096-102
references: 10225860
references: J Infect Dis. 1997 May;175(5):1176-83
references: 9129082
references: Am J Pathol. 1984 Oct;117(1):81-91
references: 6385728
references: Trends Parasitol. 2003 Jul;19(7):305-11
references: 12855381
references: Exp Parasitol. 1987 Aug;64(1):12-23
references: 2886359
references: Gastroenterology. 1996 May;110(5):1482-90
references: 8613053
references: Infect Immun. 1992 Apr;60(4):1603-12
references: 1548082
references: Infect Immun. 2004 Jun;72(6):3187-94
references: 15155620
references: Infect Immun. 1997 Sep;65(9):3951-3
references: 9284178
references: J Clin Invest. 1992 Sep;90(3):1131-7
references: 1381719
references: Infect Immun. 1992 Apr;60(4):1711-3
references: 1548096
references: Parasite Immunol. 2003 Nov-Dec;25(11-12):597-608
references: 15053781
references: Infect Immun. 2005 Aug;73(8):4522-9
references: 16040963
references: J Eukaryot Microbiol. 1998 Mar-Apr;45(2):28S-33S
references: 9561781
references: Vaccine. 2004 Jan 26;22(5-6):611-7
references: 14741152
references: Parasitol Res. 2003 Jan;89(2):146-9
references: 12489015
references: Eur J Clin Microbiol Infect Dis. 1998 Sep;17(9):601-14
references: 9832261
references: Mol Microbiol. 2006 Sep;61(6):1523-32
references: 16968225
references: Am J Trop Med Hyg. 1999 Apr;60(4 Suppl):10-5
references: 10344672
references: Infect Immun. 1995 Mar;63(3):1089-94
references: 7868232
references: J Exp Med. 1984 Aug 1;160(2):353-68
references: 6088660
references: Biochem J. 1997 Sep 15;326 ( Pt 3):785-9
references: 9307028
references: Infect Immun. 2006 Apr;74(4):2473-6
references: 16552082
references: J Parasitol. 1989 Aug;75(4):644-6
references: 2547924
references: Cell Microbiol. 2005 Feb;7(2):269-79
references: 15659070
references: Am J Trop Med Hyg. 1989 Sep;41(3):273-9
references: 2552849
references: Immunology. 1994 Dec;83(4):601-10
references: 7533135
references: Parasitol Res. 2006 Apr;98(5):493-5
references: 16374615
references: Exp Parasitol. 2006 Nov;114(3):154-9
references: 16647055
references: Infect Immun. 1997 May;65(5):1631-9
references: 9125540
references: Am J Trop Med Hyg. 2007 Feb;76(2):340-4
references: 17297046
references: Parasite Immunol. 1981 Winter;3(4):329-38
references: 6976549
references: Exp Parasitol. 2002 Aug;101(4):183-92
references: 12594958
references: Scand J Immunol. 2004 Nov;60(5):524-8
references: 15541046
references: J Immunol. 1995 Jul 1;155(1):266-74
references: 7602103
references: J Infect Dis. 2001 Jun 15;183(12):1787-93
references: 11372032
references: Parasite Immunol. 2005 Apr;27(4):127-37
references: 15910421
references: Immunobiology. 1992 Jun;185(1):1-10
references: 1398736
references: Biochem J. 1998 Mar 15;330 ( Pt 3):1217-21
references: 9494088
references: J Immunol. 2006 Sep 1;177(5):3294-302
references: 16920970
references: Infect Immun. 1991 Jan;59(1):97-101
references: 1987067
references: Parasite Immunol. 1998 May;20(5):249-53
references: 9651926
references: J Infect Dis. 1986 Jul;154(1):19-26
references: 2872253
references: Am J Trop Med Hyg. 1994 Apr;50(4):412-9
references: 8166347
references: J Infect Dis. 2002 Aug 15;186(4):547-52
references: 12195383
references: Gastroenterology. 1997 May;112(5):1536-47
references: 9136832
references: Infect Immun. 1981 Feb;31(2):571-3
references: 6260670
references: Infect Immun. 1994 May;62(5):1534-41
references: 7513301
references: J Clin Invest. 1990 Dec;86(6):1815-22
references: 2254446
references: Infect Immun. 2000 Jan;68(1):400-2
references: 10603416
references: Parasitol Res. 2003 Jul;90(4):264-7
references: 12884017
references: Gastroenterology. 1998 Dec;115(6):1446-53
references: 9834272
references: Parasite Immunol. 1998 Jun;20(6):255-62
references: 9651927
references: Parasite Immunol. 2003 Oct;25(10):475-82
references: 15157024
references: J Infect Dis. 1981 Jan;143(1):83-93
references: 6260869
references: Arch Med Res. 1992;23(2):183-5
references: 1340289