Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.
We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.
Banus
Sander
S
Laboratory of Vaccine-Preventable Diseases, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Bottema
Renske W B
RW
Siezen
Christine L E
CL
Vandebriel
Rob J
RJ
Reimerink
Johan
J
Mommers
Monique
M
Koppelman
Gerard H
GH
Hoebee
Barbara
B
Thijs
Carel
C
Postma
Dirkje S
DS
Kimman
Tjeerd G
TG
Stelma
Foekje F
FF
D000818:Animals; D015331:Cohort Studies; D006801:Humans; D007110:Immunity, Active / Q000235:genetics; D007223:Infant; D051379:Mice; D008809:Mice, Inbred C3H; D010567:Pertussis Vaccine / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide; D051197:Toll-Like Receptor 4 / Q000235:genetics* / Q000502:physiology; D014613:Vaccines, Attenuated / Q000276:immunology
D010567:Pertussis Vaccine; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D014613:Vaccines, Attenuated
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