title: 17beta-estradiol stimulates proliferation of spermatogonia in experimental cryptorchid mice.
abstract: OBJECTIVE
  To investigate whether estrogen stimulates the proliferation of spermatogonia or induces spermatogenesis in cryptorchid mice.
  
  
  METHODS
  Mice were surgically rendered cryptorchid, then treated with different doses of 17beta-estradiol (E2) s.c. once a day. Mice were killed at sexual maturity (45 days of age), and histological analysis and immunofluorescence were performed. Serum follicle stimulating hormone (FSH), estradiol, testosterone and luteinizing hormone (LH) were measured.
  
  
  RESULTS
  Low doses of E2 had no notable effect on spermatogonia, but at higher doses, E2 stimulated the proliferation of spermatogonia.
  
  
  CONCLUSIONS
  E2 has a dose-related mitogenic effect on spermatogonia.
authors: Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
authors: En-Zhong
authors: EZ
authors: Li
authors: De-Xue
authors: DX
authors: Li
authors: Shi-Qing
authors: SQ
authors: Zhang
authors: Chang-Yong
authors: CY
authors: Wang
authors: Xue-Ming
authors: XM
authors: Zhang
authors: Jing-Yan
authors: JY
authors: Lu
authors: Cui-Mi
authors: CM
authors: Duan
authors: Xiang-Zhong
authors: XZ
authors: Yang
authors: Li-Xin
authors: LX
authors: Feng
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003456:Cryptorchidism / Q000503:physiopathology*; D004195:Disease Models, Animal; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051379:Mice; D013093:Spermatogonia / Q000166:cytology* / Q000187:drug effects / Q000473:pathology; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone