Immune response regulation by leishmania secreted and nonsecreted antigens.
Leishmania infection consists in two sequential events, the host cell colonization followed by the proliferation/dissemination of the parasite. In this review, we discuss the importance of two distinct sets of molecules, the secreted and/or surface and the nonsecreted antigens. The importance of the immune response against secreted and surface antigens is noted in the establishment of the infection and we dissect the contribution of the nonsecreted antigens in the immunopathology associated with leishmaniasis, showing the importance of these panantigens during the course of the infection. As a further example of proteins belonging to these two different groups, we include several laboratorial observations on Leishmania Sir2 and LicTXNPx as excreted/secreted proteins and LmS3arp and LimTXNPx as nonsecreted/panantigens. The role of these two groups of antigens in the immune response observed during the infection is discussed.
Santarém
Nuno
N
Departamento de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, 4099-030 Porto, Portugal.
Silvestre
Ricardo
R
Tavares
Joana
J
Silva
Marta
M
Cabral
Sofia
S
Maciel
Joana
J
Cordeiro-da-Silva
Anabela
A
J Biol Chem. 2005 Feb 4;280(5):3847-61
15561707
Exp Parasitol. 1990 May;70(4):427-35
2182337
Immunology. 2006 Dec;119(4):529-40
17026719
J Biol Chem. 1990 Nov 15;265(32):19611-23
2246247
Mol Biochem Parasitol. 2004 Aug;136(2):137-47
15478793
East Afr Med J. 2003 May;80(5):260-3
16167742
Microbes Infect. 2000 Nov;2(14):1765-73
11137049
Indian J Med Res. 2006 Mar;123(3):245-66
16778308
Onderstepoort J Vet Res. 2003 Dec;70(4):255-63
14971728
J Clin Microbiol. 2002 Mar;40(3):1037-43
11880434
Exp Parasitol. 1989 Jul;69(1):100-3
2659372
Proteomics. 2006 Jul;6(14):4187-94
16791830
Science. 1995 Apr 28;268(5210):563-6
7725103
Acta Trop. 2003 Mar;85(3):375-90
12659975
J Immunol. 1987 Mar 15;138(6):1926-32
2434567
J Biol Chem. 1993 Oct 15;268(29):21835-43
8408038
Mol Biochem Parasitol. 2003 Aug 31;130(2):65-74
12946842
Parasitology. 1990 Dec;101 Pt 3:337-43
2092290
J Cell Sci. 1995 Oct;108 ( Pt 10):3219-31
7593283
Mol Microbiol. 1998 Feb;27(3):519-30
9489664
Parasitol Today. 2000 Jun;16(6):246-50
10827430
J Parasitol. 1995 Dec;81(6):1000-3
8544037
Curr Opin Microbiol. 2004 Aug;7(4):375-81
15358255
J Immunol. 2001 Mar 1;166(5):3416-22
11207299
Parasitology. 2005;130 Suppl:S27-35
16281989
Immunol Today. 2000 Sep;21(9):465-6
10953099
Immunol Lett. 2005 Oct 15;101(1):18-23
15885803
Mol Biochem Parasitol. 1988 Jan 1;27(1):43-52
3278222
Ann Trop Med Parasitol. 1987 Dec;81(6):727-9
2845873
Mem Inst Oswaldo Cruz. 2003 Oct;98(7):861-70
14762510
J Infect Dis. 1986 Dec;154(6):1003-11
3782864
Am J Trop Med Hyg. 1986 Nov;35(6):1121-8
3789268
Cell Microbiol. 2006 Dec;8(12):1922-31
16848789
Gene. 1996 Feb 22;169(1):115-8
8635734
Exp Parasitol. 1993 Dec;77(4):435-44
8253156
Clin Dermatol. 1999 May-Jun;17(3):291-6
10384868
Am J Trop Med Hyg. 2003 Mar;68(3):312-20
12685637
J Immunol. 1989 Dec 1;143(11):3743-9
2584716
Parasitology. 1996 Mar;112 ( Pt 3):277-84
8728991
Scand J Immunol. 1988 Nov;28(5):553-61
2463663
Vaccine. 2005 Apr 22;23(22):2825-40
15780731
Eur J Biochem. 1990 Jun 20;190(2):377-84
2163842
Immunology. 1998 Jun;94(2):189-96
9741340
J Immunol. 1995 Sep 15;155(6):3102-11
7673725
Infect Immun. 1998 Jul;66(7):3279-89
9632596
Biochem J. 1995 May 15;308 ( Pt 1):45-55
7755587
Parasitol Today. 2000 Jul;16(7):292-7
10858648
Adv Immunol. 2000;74:275-317
10605608
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):775-9
8421715
J Infect Dis. 1996 Jun;173(6):1515-8
8648233
Clin Microbiol Rev. 2005 Apr;18(2):293-305
15831826
Curr Pharm Des. 2002;8(4):297-318
11860368
Mol Cell Biochem. 2003 Mar;245(1-2):31-41
12708742
Parasitology. 2001 Mar;122(Pt 3):263-79
11289063
Infect Immun. 1999 Dec;67(12):6663-9
10569788
Cell Death Differ. 2002 Jan;9(1):53-64
11803374
J Exp Med. 1997 Jun 16;185(12):2061-8
9182677
Parasitology. 2006 Apr;132(Pt 4):493-509
16388694
Gene. 2005 Dec 19;363:85-96
16236469
Infect Immun. 2004 Oct;72(10):5654-61
15385463
J Biosci. 2004 Mar;29(1):15-22
15286399
Cell Microbiol. 2000 Apr;2(2):115-26
11207568
Mol Biochem Parasitol. 1994 Sep;67(1):103-13
7838170
Exp Parasitol. 1992 Sep;75(2):196-206
1516667
Biochemistry. 1995 Apr 11;34(14):4676-83
7718571
Curr Opin Immunol. 1996 Aug;8(4):517-25
8794010
Free Radic Biol Med. 1999 Nov;27(9-10):966-84
10569629
Infect Immun. 1994 Mar;62(3):1058-63
8112840
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13837-42
16945916
Exp Parasitol. 1991 Feb;72(2):191-204
2009923
J Immunol. 2004 Sep 1;173(5):3297-304
15322192
Free Radic Biol Med. 2002 Dec 1;33(11):1552-62
12446213
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10984-9
8855295
Clin Infect Dis. 1996 Jan;22(1):1-13
8824958
Kinetoplastid Biol Dis. 2005 Jan 24;4(1):1
15667659
Clin Diagn Lab Immunol. 1995 May;2(3):291-6
7664174
Trends Microbiol. 1998 Mar;6(3):102-7
9582935
J Immunol. 1995 May 1;154(9):4623-9
7722314
Gene. 2002 Aug 21;296(1-2):139-50
12383511
Immunol Lett. 2005 Jun 15;99(1):17-23
15894106
Eur J Immunol. 2003 Oct;33(10):2822-31
14515266
Semin Cell Biol. 1993 Oct;4(5):315-22
8257783
Infect Immun. 2001 Nov;69(11):6588-96
11598026
Infect Immun. 1995 Dec;63(12):4894-9
7591152
Philos Trans R Soc Lond B Biol Sci. 1997 Sep 29;352(1359):1295-302
9355120
Clin Exp Immunol. 1999 Feb;115(2):342-9
9933463
J Immunol. 1996 Dec 1;157(11):5034-41
8943412
Curr Mol Med. 2004 Sep;4(6):697-709
15357218
EMBO J. 1995 Mar 15;14(6):1067-74
7720697
Immunol Lett. 1995 Dec;48(3):209-14
8867853
Clin Microbiol Rev. 1997 Apr;10(2):298-319
9105756
Immunol Today. 1991 May;12(5):154-9
1715166
J Biol Chem. 1989 May 5;264(13):7483-9
2708373
Exp Parasitol. 1998 Jun;89(2):161-8
9635439
Infect Immun. 1999 Sep;67(9):4477-84
10456889