Brain glucose sensing, counterregulation, and energy homeostasis.
Neuronal circuits in the central nervous system play a critical role in orchestrating the control of glucose and energy homeostasis. Glucose, beside being a nutrient, is also a signal detected by several glucose-sensing units that are located at different anatomical sites and converge to the hypothalamus to cooperate with leptin and insulin in controlling the melanocortin pathway.
Marty
Nell
N
Department of Physiology and Center for Integrative Genomics, Genopode Building, University of Lausanne, Lausanne, Switzerland.
Dallaporta
Michel
M
Thorens
Bernard
B
D000818:Animals; D001069:Appetite Regulation / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D007328:Insulin / Q000502:physiology; D020738:Leptin / Q000502:physiology; D053486:Melanocortins / Q000502:physiology
D007328:Insulin; D020738:Leptin; D053486:Melanocortins; D005947:Glucose