Neural regulation of mucosal function.
Nociceptive, parasympathetic and sympathetic nerves play critical roles in regulating glandular, vascular and other processes in airway mucosa. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. Recent identification of subsets of nociceptive nerves has tipped the donkey cart of dogma and led to the discovery of new receptor and ion channel families that respond to culinary odorants ("aromatherapy"), inhaled irritants, temperature and other "humors"; a new interpretation of airway nociceptive nerve axon responses; and an understanding of the neural plasticity induced by inflammation and different neurotrophic factors.
Baraniuk
James N
JN
Division of Rheumatology, Immunology and Allergy, Room B105, Lower Level Kober-Cogan Building, Georgetown University, 3800 Reservoir Road, NW Washington, DC 20007-2197, USA. baraniuj@georgetown.edu <baraniuj@georgetown.edu>
D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D009297:Nasal Mucosa / Q000294:innervation* / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000502:physiology; D014699:Venules / Q000502:physiology
D007473:Ion Channels; D050051:Transient Receptor Potential Channels
Am J Respir Crit Care Med. 1999 Aug;160(2):655-62
10430743
Acta Otolaryngol. 1999;119(8):921-4
10728935
Am J Respir Crit Care Med. 2000 Jun;161(6):1985-90
10852778
J Allergy Clin Immunol. 2000 Dec;106(6):1045-52
11112885
Nat Neurosci. 2001 Jan;4(1):72-7
11135647
Minerva Anestesiol. 2001 Apr;67(4):206-9
11376511
Curr Opin Allergy Clin Immunol. 2002 Feb;2(1):11-9
11964745
Clin Exp Allergy. 2002 Apr;32(4):543-50
11972600
Otolaryngol Head Neck Surg. 2002 Sep;127(3):190-5
12297809
Eur J Biochem. 2004 May;271(10):1827-34
15128293
Curr Opin Neurobiol. 2004 Jun;14(3):362-9
15194117
Sci STKE. 2004 Oct 05;2004(253):re15
15467096
Am J Respir Crit Care Med. 2005 Jan 1;171(1):5-11
15477496
J Aerosol Med. 2006 Spring;19(1):110-5
16551222
Toxicol Sci. 2006 Oct;93(2):411-21
16840565
Am J Respir Cell Mol Biol. 1991 Mar;4(3):228-36
1705809
Proc Natl Acad Sci U S A. 1990 Oct;87(19):7638-42
2217195
Am J Physiol. 1990 Feb;258(2 Pt 1):L81-8
2305901
Am J Respir Cell Mol Biol. 1990 Aug;3(2):165-73
2378751
Laryngoscope. 1988 Sep;98(9):928-33
2457776
Otolaryngol Clin North Am. 1989 Apr;22(2):265-78
2748174
Clin Chest Med. 1986 Jun;7(2):159-70
3522066
Ann Otol Rhinol Laryngol. 1970 Jun;79(3):443-50
5426875
Ann Otol Rhinol Laryngol. 1969 Aug;78(4):865-79
5799406
Mayo Clin Proc. 1977 Jan;52(1):28-34
609283
Trends Pharmacol Sci. 1994 Jun;15(6):190-7
8091514
Acta Physiol Scand Suppl. 1996;632:1-45
8800374
Nature. 1997 Oct 23;389(6653):816-24
9349813