Adenosine residues in the template do not block spontaneous replication steps of RNA.
Sub-freezing temperatures, azabenzotriazolide activation, multiple monomer addition, and helper displacement help to overcome what seemed like an intrinsic block of adenine-templated RNA replication steps in the absence of enzymes.
Vogel
Stephanie R
SR
Institute for Organic Chemistry, University of Karlsruhe (TH), 76131 Karlsruhe, Germany.
Richert
Clemens
C
D000241:Adenosine / Q000737:chemistry*; D001483:Base Sequence; D019143:Evolution, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D012313:RNA / Q000737:chemistry*
C034477:RNA primers; D012313:RNA; D000241:Adenosine