Correlation between joint [F-18] FDG PET uptake and synovial TNF-alpha concentration: a study with two rabbit models of acute inflammatory arthritis.
The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-alpha concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-alpha measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-alpha ratios. An equation to estimate the TNF-alpha ratio from a MSUV was also derived.
Lin
Po-Wei
PW
Department of Physical Medicine and Rehabilitation, Taipei Medical University-Wan Fang Hospital, 111 Hsing-Long Road Sec. 3, Taipei 11696, Taiwan.
Liu
Ren-Shyan
RS
Liou
Tsan-Hon
TH
Pan
Li-Chern
LC
Chen
Chi-Hsien
CH
D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000175:diagnosis*; D004195:Disease Models, Animal; D019788:Fluorodeoxyglucose F18 / Q000032:analysis / Q000493:pharmacokinetics*; D006801:Humans; D007249:Inflammation; D016209:Interleukin-8 / Q000008:administration & dosage; D007596:Joints / Q000378:metabolism; D008070:Lipopolysaccharides / Q000009:adverse effects; D049268:Positron-Emission Tomography; D011817:Rabbits; D013582:Synovial Fluid / Q000737:chemistry*; D013583:Synovial Membrane / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D016209:Interleukin-8; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D019788:Fluorodeoxyglucose F18