title: Characterization of anti-coagulant properties of prenylated coumarin ferulenol.
abstract: We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (<100 nM), impaired factor X biosynthesis (40% reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.
authors: Dipartimento di Biochimica e Biologia Molecolare, Università di Ferrara, Italy.
authors: Monia
authors: M
authors: Monti
authors: Mirko
authors: M
authors: Pinotti
authors: Giovanni
authors: G
authors: Appendino
authors: Franco
authors: F
authors: Dallocchio
authors: Tiziana
authors: T
authors: Bellini
authors: Fabiana
authors: F
authors: Antognoni
authors: Ferruccio
authors: F
authors: Poli
authors: Francesco
authors: F
authors: Bernardi
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000633:toxicity*; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D003374:Coumarins / Q000009:adverse effects / Q000633:toxicity*; D006224:Cricetinae; D005170:Factor X / Q000096:biosynthesis; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000925:Anticoagulants; D003374:Coumarins; C092340:ferulenol; D005170:Factor X