title: Langerhans cell hyperplasia in scabies: a mimic of Langerhans cell histiocytosis.
abstract: OBJECTIVE
  In the absence of mites, the histologic diagnosis of human scabies can be difficult. Scabies can mimic a variety of inflammatory and lymphoproliferative disorders. It is under-recognized that scabies can also mimic Langerhans cell histiocytosis.
  
  
  METHODS
  Sixteen examples of scabies were reviewed histologically and immunohistochemically (CD1a, CD3, CD20, CD30 and S100).
  
  
  RESULTS
  Immunohistochemical labeling showed florid CD1a and S100 positivity in most cases, indicative of Langerhans cell hyperplasia. Scattered CD30+ lymphocytes were also typically present, within a dense infiltrate, primarily composed of T lymphocytes and eosinophils.
  
  
  CONCLUSIONS
  Because of the prominent CD1a+/S100+ component, scabies can mimic Langerhans cell histiocytosis. This finding should be considered in conjunction with scattered CD30+ cells and clinical features to avoid misdiagnosis.
authors: Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8059, USA.
authors: Pradip
authors: P
authors: Bhattacharjee
authors: Earl J
authors: EJ
authors: Glusac
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018949:Antigens, CD1 / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D003937:Diagnosis, Differential; D004804:Eosinophils / Q000378:metabolism / Q000473:pathology; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology; D007223:Infant; D017730:Ki-1 Antigen / Q000378:metabolism; D007801:Langerhans Cells / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000378:metabolism; D012532:Scabies / Q000175:diagnosis* / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology
chemical_list: D018949:Antigens, CD1; D015415:Biomarkers; C419393:CD1a antigen; D017730:Ki-1 Antigen; D009418:S100 Proteins