title: Salicylanilide acetates: synthesis and antibacterial evaluation.
abstract: A new series of salicylanilide acetates was synthesized and evaluated for their in vitro antifungal and antituberculotic activity. Some of the evaluated compounds possessed comparable or better antifungal activity than a fluconazole standard. All these compounds exhibited very good potential and their in vitro activity against drug resistant and sensitive clinical isolates of Mycobacteria were found to be equivalent or better than a standard of isoniazide, a well-known first-line drug for tuberculosis treatment.
authors: Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, Hradec Kralove, Czech Republic. jarmila.vinsova@faf.cuni.cz
authors: Jarmila
authors: J
authors: Vinsova
authors: Ales
authors: A
authors: Imramovsky
authors: Vladimir
authors: V
authors: Buchta
authors: Martina
authors: M
authors: Ceckova
authors: Martin
authors: M
authors: Dolezal
authors: Frantisek
authors: F
authors: Staud
authors: Josef
authors: J
authors: Jampilek
authors: Jarmila
authors: J
authors: Kaustova
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects; D012458:Salicylanilides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D012458:Salicylanilides; D015725:Fluconazole; C034596:salicylanilide
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