[Diagnostic difficulties in neuroborreliosis in children].
OBJECTIVE
Analysis of clinical picture in children hospitalized because of suspicion of neuroborreliosis and evaluation of usefulness of testing serum and cerebrospinal fluid (CSF) for specific antibodies.


METHODS
23 children (age: 13 months - 15.5 years) were hospitalized: 11 children with facial palsy, 2 children with radiculopathy and 10 children with headache. In 21 children lumbar puncture and CSF examination was done. Serum of all children and CSF of 21 children were tested by ELISA for specific antibodies (IDEIA DakoCytomation).


RESULTS
Meningeal signs in physical examination were found in 4 children and inflammatory CSF changes in 8 children. Specific antibodies in sera of 19 children and in CSF of 7 children. Neuroborreliosis was diagnosed in 12 children: in 9 facial palsy (in 6 with inflammatory CSF changes), in 2 Bannwarth's syndrome and in 1 aseptic meningitis. Diagnosis was confirmed by detection of specific antibodies in sera of 10 children and in CSF of 6 children.


CONCLUSIONS
Meningitis in the course of neuroborreliosis is not always accompanied by meningeal signs. Positive serology is not an unequivocal confirmation of neuroborreliosis especially if symptoms are nonspecific (e.g. headache).
Talarek
Ewa
E
Klinika Chorób Zakaźnych Wieku Dzieciecego AM w Warszawie.
Duszczyk
Ewa
E
Zarnowska
Hanna
H
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid; D025065:Borrelia burgdorferi / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005155:Facial Nerve Diseases / Q000175:diagnosis / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D020852:Lyme Neuroborreliosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000276:immunology*; D008297:Male; D008582:Meningitis, Aseptic / Q000175:diagnosis; D016920:Meningitis, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D013129:Spinal Puncture
D000907:Antibodies, Bacterial