Polymerase switching in DNA replication.
Our view of DNA replication has been of two coupled DNA polymerases anchored to the replication fork helicase in a "replisome" complex, synthesizing leading and lagging strands simultaneously. New evidence suggests that three DNA polymerases can be accommodated into the replisome and that polymerases and repair factors are dynamically recruited and engaged without dismantling of the replisome.
Lovett
Susan T
ST
Department of Biology and Rosenstiel Basic Medical Sciences Research Institute, MS029, Brandeis University, Waltham, MA 02454-9110, USA. lovett@brandeis.edu
D017123:Bacteriophage T7 / Q000201:enzymology; D004260:DNA Repair; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology
D004259:DNA-Directed DNA Polymerase