[Herb-drugs interactions].
Herbal therapeutics are increasingly associated with herb drug interactions. The vast majority of the purported cases is unsubstantiated and misinterpreted. Pharmacological and clinical studies should only be demanded in cases of reliable evidence. First steps to be taken by manufacturers of herbal drugs should be in vitro studies with metabolizing systems like CYP and P-gp. Manufacturers of drugs that are metabolized by modulated systems should be requested to conduct drug specific interaction studies as necessary.
Freudenstein
Johannes
J
Schaper & Brümmer GmbH & Co. KG, Salzgitter, Germany. Johannes.Freudenstein@Schaper-Bruemmer.de
Nisslein
Thomas
T
D017277:Drug Approval; D004345:Drug Industry / Q000592:standards; D005858:Germany; D041743:Herb-Drug Interactions; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*
D010936:Plant Extracts
Phytomedicine. 2004 Feb;11(2-3):98-104
15070158
J Geriatr Psychiatry Neurol. 1999 Spring;12(1):7-10
10447148
Curr Pharm Des. 2006;12(35):4649-64
17168768
J Clin Pharmacol. 2001 Nov;41(11):1149-79
11697750
Ann Pharmacother. 2000 Sep;34(9):1013-6
10981246
Can J Psychiatry. 2006 Apr;51(5):300-16
16986820
Arzneimittelforschung. 2004;54(6):307-13
15282874
Int J Clin Pharmacol Ther. 2000 Oct;38(10):500-2
11073292
Planta Med. 2004 Sep;70(9):784-91
15386186
Br J Clin Pharmacol. 1979 Nov;8(5):483-9
508556
Eur J Pharm Sci. 2006 Apr;27(5):501-17
16364611
J Clin Invest. 1999 Jul;104(2):147-53
10411543
Drugs. 2005;65(9):1239-82
15916450
J Psychopharmacol. 2002 Dec;16(4):401
12503845
Rapid Commun Mass Spectrom. 2004;18(19):2273-81
15384148