title: Biocompatibility assessment of synthetic sling materials for female stress urinary incontinence.
abstract: OBJECTIVE
  We evaluated the performance and complications of currently available synthetic sling materials with a focus on in vitro and in vivo biocompatibility, and acceptance in the human body.
  
  
  METHODS
  We reviewed the MEDLINE database for relevant literature pertaining to various synthetic sling materials. The Food and Drug Administration regulations regarding the regulation and biocompatibility testing of synthetic meshes were also reviewed.
  
  
  RESULTS
  Many synthetic meshes used for sling construction were introduced before rigorous Food and Drug Administration regulations were passed and, thus, some became associated with unique complications. Most meshes used in pubovaginal and mid urethral sling surgery are associated with high short-term success rates and relatively few intraoperative complications. Despite modifications and additives, slings constructed from polytetrafluoroethylene and polyethylene are poorly accepted by the human body. Flexible, macroporous, polypropylene meshes appear to integrate more completely with human tissue than other synthetic materials. However, multifilament and nonknitted polypropylene slings may integrate poorly.
  
  
  CONCLUSIONS
  The composition, weave and pore size of each material are unique. These properties are responsible for the strength and durability of the material, as well as the ultimate acceptance and incorporation in the human body. Each material should be individually evaluated and patients should be counseled appropriately before implantation.
authors: Department of Urology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.
authors: Alex
authors: A
authors: Gomelsky
authors: Roger R
authors: RR
authors: Dmochowski
mesh_terms: D004867:Equipment Design; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology; D006801:Humans; D008422:Materials Testing; D011183:Postoperative Complications / Q000209:etiology; D016032:Randomized Controlled Trials as Topic; D053825:Suburethral Slings; D014550:Urinary Incontinence, Stress / Q000601:surgery*