Effect of fat supplementation on leptin, insulin-like growth factor I, growth hormone, and insulin in cattle.
We investigated the effect of fat supplementation on plasma levels of hormones related to metabolism, with special attention to leptin, in cows in early lactation and in feedlot steers. In experiment 1, 34 lactating cows received no fat or else 0.5 or 1.0 kg of partially hydrogenated oil per day in addition to their basal diet from day 20 before the expected calving date to day 70 postpartum. In experiment 2, part of the corn in the basal concentrate was replaced with 0.7 kg of the same oil such that the diets were isocaloric; 18 cows received the fat-substituted diet and 18 a control diet from day 20 before the expected calving date to day 75 postpartum. In experiment 3, calcium salts of fatty acids were added to the basal diet of 14 feedlot steers for 80 d; another 14 steers received a control diet. The basal plasma levels of leptin were higher in the cows than in the steers. Dietary fat supplementation did not affect the leptin levels in the lactating cows but lowered the levels in the feedlot steers despite greater energy intake and body fatness (body weight) in the steers receiving the supplement than in those receiving the control diet. The levels of insulin-like growth factor I and insulin were decreased with dietary fat supplementation in the lactating cows but were unaffected in the steers, suggesting that responses to fat ingestion depend on the physiological state of the animal, including age and sex. Finally, no effects of supplementary fat on the level of growth hormone were demonstrated in any of the models.
Becú-Villalobos
Damasia
D
Laboratorio de Regulaci6n Hipofisaria, Instituto de Biología y Medicina Experimental, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina.
García-Tornadú
Isabel
I
Shroeder
Guillermo
G
Salado
Eloy E
EE
Gagliostro
Gerardo
G
Delavaud
Carole
C
Chilliard
Yves
Y
Lacau-Mengido
Isabel M
IM
D000367:Age Factors; D000824:Animal Nutritional Physiological Phenomena / Q000502:physiology*; D000818:Animals; D002417:Cattle; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006865:Hydrogenation; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007774:Lactation / Q000378:metabolism*; D020738:Leptin / Q000097:blood*; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011897:Random Allocation; D012737:Sex Factors
D004042:Dietary Fats, Unsaturated; D007328:Insulin; D020738:Leptin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
J Anim Sci. 2003 Jan;81(1):261-8
12597397
J Endocrinol. 2000 May;165(2):519-26
10810316
J Dairy Sci. 1998 Mar;81(3):856-71
9565891
Trends Endocrinol Metab. 1998 Apr;9(3):117-24
18406252
Metabolism. 2000 Mar;49(3):326-30
10726909
J Dairy Sci. 2004 May;87(5):1265-78
15290975
Domest Anim Endocrinol. 2005 Jul;29(1):3-22
15876510
J Dairy Sci. 1991 Jun;74(6):1893-903
1894799
Trends Endocrinol Metab. 2000 Oct;11(8):327-32
10996528
J Anim Sci. 2002 Aug;80(8):2023-30
12211368
J Endocrinol. 2001 Nov;171(2):339-48
11691654
Reprod Nutr Dev. 1999 Jan-Feb;39(1):27-48
10222498
J Dairy Sci. 1993 Dec;76(12):3897-931
8132894
J Dairy Sci. 2005 Feb;88(2):726-40
15653539
J Anim Sci. 2004 Mar;82(3):851-9
15032443
Domest Anim Endocrinol. 2004 Jan;26(1):33-48
14732451
J Dairy Sci. 2000 Mar;83(3):569-76
10750115
Annu Rev Physiol. 2000;62:413-37
10845097
J Anim Sci. 2000 Oct;78(10):2497-503
11048912
J Dairy Sci. 1992 Feb;75(2):492-501
1313841
J Anim Sci. 1999 Jun;77(6):1329-34
10375208
J Dairy Sci. 1996 Oct;79(10):1836-49
8923255
J Nutr. 2003 Dec;133(12):4163-71
14652366
J Dairy Sci. 2002 Mar;85(3):580-94
11949863
J Lipid Res. 1998 Aug;39(8):1655-60
9717726
Reprod Domest Anim. 2003 Jun;38(3):182-6
12753550
J Anim Sci. 2000 Apr;78(4):817-24
10784170
Domest Anim Endocrinol. 2000 Oct;19(3):159-75
11064219
Ann N Y Acad Sci. 2000;900:174-83
10818404
J Dairy Sci. 2002 Nov;85(11):3026-34
12487468
Domest Anim Endocrinol. 2001 Nov;21(4):271-95
11872321
Endocrine. 2002 Dec;19(3):249-56
12624424
Reproduction. 2004 Jun;127(6):727-37
15175509
Reproduction. 2002 Jul;124(1):119-31
12090925
J Anim Sci. 2002 May;80(5):1317-28
12019621
J Anim Sci. 1995 Jul;73(7):2086-93
7592095
J Anim Sci. 2000 Sep;78(9):2244-52
10985394
J Dairy Sci. 2003 Oct;86(10):3206-14
14594240
J Anim Sci. 1997 Sep;75(9):2512-9
9303470