Continuous evidence of fast HIV disease progression related to class-wide resistance to antiretroviral drugs: a 6 year follow-up analysis of a large observational database.
Class-wide resistance (CWR) was increasingly associated with a higher risk of HIV progression after 72 months of follow-up among 1392 patients genotypic-tested after failure (AIDS risk 13% for no CWR to 34% for three CWR; AIDS/death risk 21-54%). At multivariate analysis, the detection of two and three CWR was significantly associated with a two and threefold increased risk, respectively, of death and AIDS/death, suggesting that extended resistance is a marker of disease progression in long-term observation.
Mauro
Zaccarelli
Z
Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy.
Federica
Forbici
F
Patrizia
Lorenzini
L
Francesca
Ceccherini-Silberstein
CS
Valerio
Tozzi
T
Paola
Trotta Maria
TM
Patrizia
Marconi
M
Pasquale
Narciso
N
Federico
Perno Carlo
PC
Andrea
Antinori
A
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018450:Disease Progression; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D016896:Treatment Outcome