[The role of lamins and mutations of LMNA gene in physiological and premature aging].
Lamins belong to type V intermediate filaments superfamily. They are the main structural constituencies of the nuclear lamina but they also influence on chromatin structure, regulation of gene expression, localization and probably protein degradation. Because lamins play many different roles within the cell, mutations in their genes can results in variety of pathological phenotypes. Mutations in LMNA gene are the cause of many different diseases, called laminopathies. Among laminopathies are muscle tissue diseases, adipose tissue diseases and also progerias, the premature aging syndromes. One of the progerias, which results from mutation in LMNA gene, is Hutchinson-Gilford progeria syndrome (HGPS). It seems that the same molecular mechanisms which are responsible for premature aging of cells of HGPS patients, are involved in physiological aging.
Sliwińska
Małgorzata Alicja
MA
Pracownia Molekularnych Podstaw Starzenia, Zakład Biochemii, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego PAN, Warszawa. m.sliwinska@nencki.gov.pl
D000375:Aging / Q000235:genetics* / Q000378:metabolism; D019588:Aging, Premature / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D020022:Genetic Predisposition to Disease; D006801:Humans; D034904:Lamin Type A / Q000235:genetics* / Q000378:metabolism; D034882:Lamins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009154:Mutation / Q000235:genetics*; D009685:Nuclear Envelope / Q000235:genetics* / Q000378:metabolism; D015530:Nuclear Matrix / Q000235:genetics / Q000378:metabolism; D011371:Progeria / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism
D034904:Lamin Type A; D034882:Lamins; D020033:Protein Isoforms