Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients.
A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.
Meletiadis
Joseph
J
National Cancer Institute, Bethesda, MD, USA.
Walsh
Thomas J
TJ
Choi
Eun Hwa
EH
Pappas
Peter G
PG
Ennis
David
D
Douglas
Jeffrey
J
Pankey
George A
GA
Larsen
Robert A
RA
Hamill
Richard J
RJ
Chanock
Stephen
S
D015703:Antigens, CD / Q000235:genetics*; D016022:Case-Control Studies; D003453:Cryptococcosis / Q000453:epidemiology / Q000235:genetics*; D003455:Cryptococcus neoformans; D005260:Female; D058851:GPI-Linked Proteins; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018023:HIV Seronegativity; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D012307:Risk Factors; D044465:White People
D015703:Antigens, CD; C445323:FCGR2A protein, human; C496124:FCGR3A protein, human; C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D017452:Receptors, IgG