Diabetes does not influence oral oncogenesis through fibroblast growth factor receptors.
BACKGROUND
Increased expression of fibroblast growth factors and their receptors (FGFRs) has recently been described in oral squamous cell carcinoma. In addition, we have previously described a molecular basis for an association between oral cancer and diabetes. The expression of FGFR-2 and FGFR-3 investigated in an experimental model of chemically induced carcinogenesis in normal and diabetic (type I) rats.


METHODS
Tissue sections ranging from normal mucosa to moderately-differentiated oral squamous cell carcinoma were studied using monoclonal antibodies against FGFR-2 and FGFR-3 proteins.


RESULTS
A similar pattern of elevated FGFR-2 and FGFR-3 expression was observed in the initial stages of oncogenesis for both diabetic and non-diabetic animals. In the last stages of oral oncogenesis, the expression of both proteins remained relatively stable.


CONCLUSIONS
It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis.
Vairaktaris
Eleftherios
E
Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Athens, Greece. lvairakt@med.uoa.gr
Goutzanis
Lambros
L
Nkenke
Emeka
E
Spyridonidou
Sofia
S
Vassiliou
Stavros
S
Derka
Spyridoula
S
Vylliotis
Antonis
A
Yapijakis
Christos
C
Lazaris
Andreas
A
Strantzias
Pashalis
P
Kalimeras
Eleftherios
E
Patsouris
Efstratios
E
D000818:Animals; D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000276:immunology / Q000378:metabolism*; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000276:immunology / Q000378:metabolism*
D000911:Antibodies, Monoclonal; C069820:Fgfr3 protein, rat; C496356:Fgfr2 protein, rat; D051497:Receptor, Fibroblast Growth Factor, Type 2; D051498:Receptor, Fibroblast Growth Factor, Type 3