Beneficial effects of r-h-CLU on disease severity in different animal models of peripheral neuropathies.
Clusterin is a protein involved in multiple biological events, including neuronal cytoprotection, membrane recycling and regulation of complement-mediated membrane attack after injury. We investigated the effect of recombinant human clusterin in preclinical models of peripheral neuropathies. Daily treatment with clusterin accelerated the recovery of nerve motor evoked potential parameters after sciatic nerve injury. Prophylactic or therapeutic treatment of experimental autoimmune neuritis rats with clusterin also accelerated the rate of recovery from the disease, associated with remyelination of demyelinated nerve fibers. These data demonstrate that clusterin is capable of ameliorating clinical, neurophysiological and pathological signs in models of peripheral neuropathies.
Dati
G
G
RBM, Società soggetta all'attività di direzione e coordinamento da parte della Merck Serono S.A., Turin, Italy. Gabriele.Dati@merckserono.net
Quattrini
A
A
Bernasconi
L
L
Malaguti
M C
MC
Antonsson
B
B
Nicoletti
F
F
Alliod
C
C
Di Marco
R
R
Sagot
Y
Y
Vitte
P A
PA
Hiver
A
A
Greco
B
B
Roach
A
A
Zaratin
P F
PF
D000818:Animals; D051152:Clusterin / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D016207:Cytokines / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006624:Hippocampus / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D004676:Myelin Basic Protein / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D009186:Myelin Sheath / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D009414:Nerve Growth Factors / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D009416:Nerve Regeneration / Q000187:drug effects* / Q000276:immunology; D009474:Neurons / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D009924:Organ Culture Techniques; D010525:Peripheral Nerves / Q000187:drug effects* / Q000276:immunology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D011994:Recombinant Proteins / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use; D020426:Sciatic Neuropathy / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D016896:Treatment Outcome
C495242:CLU protein, human; D051152:Clusterin; D016207:Cytokines; D004676:Myelin Basic Protein; D009414:Nerve Growth Factors; D011994:Recombinant Proteins