title: Improved efficacy of a licensed acellular pertussis vaccine, reformulated in an adjuvant emulsion of liposomes in oil, in a murine model.
abstract: The immunogenicities and efficacies of a licensed diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine and the same vaccine formulated in a liposome/oil emulsion adjuvant were compared in a mouse model of pertussis respiratory infection. A single dose of the liposome/oil emulsion-adjuvanted vaccine produced significantly higher antibody levels than one dose of the licensed vaccine and protected mice from Bordetella pertussis infection with an efficacy equivalent to that of three doses of the licensed vaccine.
authors: ImmunoVaccine Technologies Inc., Dalhousie University, Halifax, Nova Scotia, Canada.
authors: Marc
authors: M
authors: Mansour
authors: Robert G
authors: RG
authors: Brown
authors: Annette
authors: A
authors: Morris
authors: Bruce
authors: B
authors: Smith
authors: Scott A
authors: SA
authors: Halperin
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology*; D017277:Drug Approval; D016503:Drug Delivery Systems; D004655:Emulsions; D005260:Female; D007115:Immunization Schedule; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D009821:Oils; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology* / Q000592:standards; D022282:Vaccines, Acellular / Q000008:administration & dosage / Q000276:immunology / Q000592:standards
chemical_list: D000276:Adjuvants, Immunologic; D004655:Emulsions; D008081:Liposomes; D009821:Oils; D010567:Pertussis Vaccine; D022282:Vaccines, Acellular
references: Vaccine. 2006 Jun 12;24(24):5235-44
references: 16675074
references: Clin Invest Med. 1988 Aug;11(4):297-303
references: 3168352
references: Infect Immun. 2003 Apr;71(4):2272-5
references: 12654855
references: MMWR Morb Mortal Wkly Rep. 1995 Jul 21;44(28):525-9
references: 7603428
references: Nat Rev Immunol. 2002 Apr;2(4):291-6
references: 12002000
references: Expert Rev Vaccines. 2006 Apr;5(2):175-87
references: 16608418
references: Microbes Infect. 2001 Jul;3(8):655-77
references: 11445452
references: J Reprod Immunol. 1997 Nov 1;35(1):53-64
references: 9373858