Memory T cells in allograft rejection.
T cell repertoire of many humans contains high frequencies of memory T cells specific for alloantigens. The increasing evidence implicates these cells as a barrier to allograft survival and to the induction of transplantation tolerance. This review discusses several aspects of memory T cell immunobiology pertinent to their role in transplantation.
Valujskikh
Anna
A
The Cleveland Clinic Foundation, Department of Immunology, Cleveland, OH, USA. valujsa@ccf.org
D000818:Animals; D006084:Graft Rejection; D006801:Humans; D007107:Immune System; D007108:Immune Tolerance; D007156:Immunologic Memory; D008285:Major Histocompatibility Complex; D051379:Mice; D008954:Models, Biological; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D023001:Transplantation Tolerance