[Statin drugs decrease the plasma level of coenzyme Q10 (ubiquinone) in the organism].
In this paper the authors review the relationship and the possible interaction between the HMG-CoA reductase inhibitors (statins) and the CoQ10 (ubiquinone) based on the current literature. The statins are widely used in the clinical practice. Inhibiting the synthesis of mevalonic acid they decrease the plasma cholesterol level. Since mevalonic acid is also required for ubiquinone synthesis statins could influence ubiquinone metabolism. Many studies confirmed the relationship between statin therapy and lower plasma ubiquinone level. Much less data are available about the tissue concentration changes of ubiquinone during statin therapy. The authors try to summarise the consequences of the interaction between statin therapy and ubiquinone metabolism.
Rákóczi
Károly
K
Szegedi Tudományegyetem, Neurológiai Klinika, Szeged.
Párdutz
Arpád
A
Vécsei
László
L
D000924:Anticholesteremic Agents / Q000494:pharmacology*; D003067:Coenzymes / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood / Q000187:drug effects / Q000378:metabolism
D000924:Anticholesteremic Agents; D003067:Coenzymes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014451:Ubiquinone; C024989:coenzyme Q10