CNS proteomes in alcohol and drug abuse and dependence.
Drugs of abuse, including alcohol, can induce dependency formation and/or brain damage in brain regions important for cognition. 'High-throughput' approaches, such as cDNA microarray and proteomics, allow the analysis of global expression profiles of genes and proteins. These technologies have recently been applied to human brain tissue from patients with psychiatric illnesses, including substance abuse/dependence and appropriate animal models to help understand the causes and secondary effects of these complex disorders. Although these types of studies have been limited in number and by proteomics techniques that are still in their infancy, several interesting hypotheses have been proposed. Focusing on CNS proteomics, we aim to review and update current knowledge in this rapidly advancing area.
Matsumoto
Izuru
I
University of Sydney, Discipline of Pathology, NSW, Australia. izuru@med.usyd.edu.au
Alexander-Kaufman
Kimberley
K
Iwazaki
Takeshi
T
Kashem
Mohammed Abul
MA
Matsuda-Matsumoto
Haruka
H
D000437:Alcoholism / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D003072:Cognition Disorders / Q000378:metabolism; D018076:DNA, Complementary; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011180:Postmortem Changes; D020543:Proteome; D019966:Substance-Related Disorders / Q000378:metabolism*
D018076:DNA, Complementary; D020543:Proteome