title: Severe Henoch-Schönlein purpura in a thalassemic patient under deferiprone treatment.
abstract: Herein we present a 7-year-old beta-thalassemia major patient who developed severe Henoch-Schönlein purpura (HSP) with renal, pulmonary involvement and invagination while under iron chelation with deferiprone. DNA analysis for familial Mediterranean fever revealed M696V mutation. Various cellular and humoral immunological impairments have been described in thalassemia major patients and the severe course of HSP in our case may be related to these underlying immunological defects.
authors: Division of Pediatric Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. suleunal@hacettepe.edu.tr
authors: Sule
authors: S
authors: Unal
authors: Safak
authors: S
authors: Gücer
authors: Gülsev
authors: G
authors: Kale
authors: Nesrin
authors: N
authors: Besbas
authors: Seza
authors: S
authors: Ozen
authors: Fatma
authors: F
authors: Gümrük
mesh_terms: D019943:Amino Acid Substitution; D002648:Child; D004247:DNA / Q000235:genetics; D000077543:Deferiprone; D010505:Familial Mediterranean Fever / Q000235:genetics; D006801:Humans; D011695:IgA Vasculitis / Q000139:chemically induced*; D007502:Iron Chelating Agents / Q000009:adverse effects*; D008297:Male; D011728:Pyridones / Q000009:adverse effects*; D013156:Splenectomy; D017086:beta-Thalassemia / Q000188:drug therapy*
chemical_list: D007502:Iron Chelating Agents; D011728:Pyridones; D000077543:Deferiprone; D004247:DNA