Reference levels for 17-hydroxyprogesterone, 11-desoxycortisol, cortisol, testosterone, dehydroepiandrosterone sulfate and androstenedione in infants from birth to six months of age.
Reference plasma adrenal steroid levels during early infancy are frequently used to verify hormone measurements when any adrenal abnormality is suspected. We aim to obtain longitudinal reference plasma levels for 17-hydroxyprogesterone (17OHP), 11-desoxycortisol (11DOC), cortisol, dehydroepiandrosterone sulfate (DHEAS), testosterone, and androstenedione in healthy infants from birth to 6 months of age. In 138 term infants, 80 males and 58 females, plasma steroid levels were measured using specific RIA procedures at birth and on the 3rd, 15th, 30th, 60th, 90th, 120th, 150th, and 180th days of life. Smoothed percentiles for each variable were calculated according to the LMS method (LMS program version 1.16, Institute of Child Health, London). Except for cortisol, plasma levels of adrenal steroids decreased progressively from birth to 6 months of age. Plasma concentrations of 17OHP, 11DOC, and cortisol did not show gender differences, but testosterone and androstenedione were significantly higher in boys, and DHEAS levels were higher in girls. Longitudinal reference plasma levels for 17OHP, 11DOC, cortisol, DHEAS, testosterone, and androstenedione have been described in an adequate sample of healthy infants from birth to 6 months of age. These standards, displayed as smoothed percentiles, may be used as reference values in the management of congenital endocrine (adrenal or gonadal) abnormalities that appear in the first weeks of life.
Garagorri
Jesús M
JM
Departamento de Pediatría, Hospital Clínico Universitario Lozano Blesa, University of Zaragoza, Zaragoza, Spain.
Rodríguez
Gerardo
G
Lario-Elboj
Angel J
AJ
Olivares
José L
JL
Lario-Muñoz
Angel
A
Orden
Isabel
I
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000735:Androstenedione / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007223:Infant; D008131:London; D008137:Longitudinal Studies; D008297:Male; D011863:Radioimmunoassay; D012016:Reference Values; D013739:Testosterone / Q000097:blood
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D000735:Androstenedione; D019314:Dehydroepiandrosterone Sulfate; D019326:17-alpha-Hydroxyprogesterone; D006854:Hydrocortisone
J Clin Endocrinol Metab. 1968 Aug;28(8):1133-42
5676177
J Clin Endocrinol Metab. 1976 Apr;42(4):679-86
1262442
Eur J Clin Nutr. 1990 Jan;44(1):45-60
2354692
Pediatr Res. 1988 May;23(5):525-9
3387174
J Clin Endocrinol Metab. 1991 Sep;73(3):674-86
1651957
J Clin Endocrinol Metab. 1978 Jun;46(6):971-85
263476
An Esp Pediatr. 2000 Feb;52(2):106-15
11003876
Horm Res. 2002;58(4):196-205
12324719
J Clin Endocrinol Metab. 1978 Sep;47(3):572-7
162515
J Clin Invest. 1974 Mar;53(3):819-28
4812441
Pediatr Res. 1999 Sep;46(3):323-7
10473049
Arch Dis Child Fetal Neonatal Ed. 2004 Nov;89(6):F558-9
15499155
J Pediatr. 1987 Jan;110(1):122-4
3794871