Relationship between P50 suppression and the cortical silent period.
Deficient inhibitory neurotransmission has been demonstrated in schizophrenia through electroencephalography (e.g. P50 suppression) and transcranial magnetic stimulation (e.g. short-interval cortical inhibition and the cortical silent period). It is not known whether these inhibitory paradigms are related despite evidence suggesting that both are coordinated through gamma-aminobutyric acid inhibitory neurotransmission. We explored the relationship between P50 suppression, short-interval cortical inhibition and the cortical silent period in 21 healthy participants using previously published methods. P50 suppression was significantly correlated with cortical silent period (r=-0.49, P=0.02) but not with short-interval cortical inhibition. As both P50 suppression and the cortical silent period have been linked to gamma-aminobutyric acidB receptor-mediated inhibitory neurotransmission, these data highlight the importance of this receptor subtype in the pathophysiology of schizophrenia.
Möller
Bertram
B
Schizophrenia Program, Centre for Addiction and Mental Health, Universty of Toronto, 250 College Street, M5T IR8, Toronto, Ontario, Canada.
Light
Gregory A
GA
Fitzgerald
Paul B
PB
Snyder
Joel S
JS
Chen
Robert
R
Daskalakis
Zafiris J
ZJ
D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography; D004576:Electromyography / Q000379:methods; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D006185:Habituation, Psychophysiologic; D006801:Humans; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D013216:Reflex, Startle / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation