title: Effect of vitamin E on oxidative stress status in small intestine of diabetic rat.
abstract: OBJECTIVE
  To investigate the effect of vitamin E on oxidative stress status in the small intestine of diabetic rats.
  
  
  METHODS
  Twenty-four male Wistar rats were randomly divided into three groups: Control (C), non-treated diabetic (NTD) and vitamin E-treated diabetic (V(E)TD) groups. The increases in lipid peroxidation, protein oxidation and superoxide dismutase (SOD) in these three groups was compared after 6 wk.
  
  
  RESULTS
  There was no significant difference in catalase activity between NTD and control rats. Compared to NTD rats, the treatment with vitamin E significantly decreased lipid peroxidation and protein oxidation, and also increased catalase activity and SOD.
  
  
  CONCLUSIONS
  The results revealed the occurrence of oxidative stress in the small intestine of diabetic rats. Vitamin E, as an antioxidant, attenuates lipid peroxidation and protein oxidation, and increases antioxidant defense mechanism.
authors: Department of Physiology, Faculty of Medicine, Jaddeh Nazloo, Urmia, Iran. ashirpoor@yahoo.com
authors: A
authors: A
authors: Shirpoor
authors: M-H-Khadem
authors: MH
authors: Ansari
authors: S
authors: S
authors: Salami
authors: F-Ghaderi
authors: FG
authors: Pakdel
authors: Y
authors: Y
authors: Rasmi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D007421:Intestine, Small / Q000187:drug effects / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D013311:Streptozocin; D002374:Catalase; D013482:Superoxide Dismutase
references: Nutr Rev. 1993 Nov;51(11):339-40
references: 8108035
references: Endocr Rev. 2002 Oct;23(5):599-622
references: 12372842
references: Mol Cell Biochem. 1995 Oct 18;151(2):113-9
references: 8569756
references: Biochem Mol Biol Int. 1998 Apr;44(4):647-56
references: 9584978
references: Chem Res Toxicol. 1997 Aug;10 (8):895-905
references: 9282839
references: FEBS Lett. 2002 May 22;519(1-3):8-10
references: 12023009
references: J Clin Invest. 1991 Jun;87(6):1910-5
references: 1904067
references: J Surg Res. 2000 Dec;94(2):178-84
references: 11104659
references: Diabetes Care. 2001 Feb;24(2):371-81
references: 11213895
references: Am J Physiol Heart Circ Physiol. 2001 Dec;281(6):H2289-94
references: 11709394
references: Biometals. 1998 Apr;11(2):153-7
references: 9542068
references: J Bioenerg Biomembr. 1994 Aug;26(4):349-58
references: 7844109
references: J Lipid Res. 2003 Oct;44(10 ):1940-5
references: 12867540
references: Diabetes. 1999 Jun;48(6):1270-4
references: 10342815
references: J Physiol Biochem. 2006 Sep;62(3):171-7
references: 17451158
references: Toxicology. 2000 Nov 16;153(1-3):83-104
references: 11090949
references: Chemosphere. 1999 Jun;38(13):3003-13
references: 10230044
references: Virchows Arch. 1995;426(5):501-7
references: 7633660
references: Curr Pharm Des. 2004;10(14):1611-26
references: 15134560
references: Biochim Biophys Acta. 1995 May 24;1271(1):195-204
references: 7599208
references: Free Radic Biol Med. 1994 Nov;17(5):429-37
references: 7835749
references: Gastroenterol Clin North Am. 1998 Dec;27(4):861-74, vi-vii
references: 9890116
references: Free Radic Biol Med. 1995 May;18(5):949-53
references: 7797106
references: Diabetes Care. 2004 Sep;27(9):2166-71
references: 15333479
references: Free Radic Biol Med. 1999 Aug;27(3-4):334-46
references: 10468207
references: Life Sci. 1995;56(2):83-9
references: 7823762
references: J Nutr. 2000 Jul;130(7):1649-52
references: 10867030
references: Free Radic Biol Med. 1991;10(5):339-52
references: 1855674
references: Biochim Biophys Acta. 1986 Oct 9;861(2):311-8
references: 3756162
references: Singapore Med J. 2006 Aug;47(8):670-5
references: 16865205
references: FEBS Lett. 1988 Aug 29;236(2):406-10
references: 2842191
references: Diabetes. 1999 Jan;48(1):1-9
references: 9892215
references: Ann N Y Acad Sci. 2001 Jun;939:200-15
references: 11462772
references: Can J Physiol Pharmacol. 1990 May;68(5):630-5
references: 2187577
references: Dig Liver Dis. 2002 Oct;34(10):707-16
references: 12469798
references: Dig Dis Sci. 2000 Dec;45(12):2271-81
references: 11258545
references: Diabetes. 1982 May;31(5 Pt 1):388-95
references: 7152132
references: J Biol Chem. 1986 Dec 15;261(35):16404-9
references: 3782126
references: Int J Biochem Cell Biol. 2004 Jan;36(1):89-97
references: 14592535
references: Biol Signals Recept. 2000 May-Aug;9(3-4):137-59
references: 10899700
references: Free Radic Res. 2000 Dec;33(6):819-30
references: 11237104
references: N Engl J Med. 1976 Aug 19;295(8):417-20
references: 934240
references: J Biol Chem. 1985 Oct 15;260(23):12405-9
references: 3900076