title: [Antithymocyte globulin used for treatment of severe acute graft versus host disease after haploidentical bone marrow transplantation].
abstract: The objective of study was to investigate the effect of low-dose antithymocyte globulin (ATG) on steroid-resistant severe acute graft versus host disease (aGVHD). Six patients with steroid-resistant severe aGVHD after haploidentical bone marrow transplantation (BMT) received the treatment with ATG at a low dose of 1.25 mg/kg for 3 - 5 doses every other day. The results showed that 3 out of 6 patients got completely remission (CR), among them 2 patients have still been in disease-free survival, 1 patient died from leukemia relapse. 1 out of the other 3 patients got partial remissin (PR), 2 patients were aggravated. The other 3 patients all died from GVHD. The major complications observed in these patients were infections. In conclusion, low-dose ATG is effective for some patients with steroid-resistant severe aGVHD, and has not severe side effect. To strengthen environmental protection should be considered as important for prevention of infection.
authors: Department of Hematology, Air Force General Hospital of PLA, Beijing 100036, China. liujingemail@126.com
authors: Jing
authors: J
authors: Liu
authors: Heng-Xiang
authors: HX
authors: Wang
authors: Lian-Ning
authors: LN
authors: Duan
authors: Mei
authors: M
authors: Xue
authors: Ling
authors: L
authors: Zhu
authors: Hong-Min
authors: HM
authors: Yang
authors: Li
authors: L
authors: Ding
authors: Shu-Quan
authors: SQ
authors: Ji
mesh_terms: D000293:Adolescent; D000328:Adult; D000961:Antilymphocyte Serum / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000209:etiology; D006680:HLA Antigens / Q000276:immunology; D006239:Haplotypes / Q000276:immunology; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D000961:Antilymphocyte Serum; D006680:HLA Antigens