title: Role of apolipoprotein E in anxiety.
abstract: Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated signaling and steroidogenesis in the adrenal gland. In addition, human apoE isoforms have differential effects on anxiety in adult mice lacking apoE and probable AD patients. Compared to wild-type mice, mice lacking apoE and apoE4 mice showed pathological alterations in the central nucleus of the amygdala, which is involved in regulation of anxiety. ApoE4, but not mice lacking apoE, or apoE3 mice showed impaired dexamethasone suppression of plasma corticosterone. Understanding how apoE modulates measures of anxiety might help the developments of therapeutic targets to reduce or even prevent measures of anxiety in health and in dementing illnesses.
authors: Department of Behavioral Neuroscience, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, L470, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
authors: Jacob
authors: J
authors: Raber
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000523:psychology; D000679:Amygdala / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000523:psychology; D053318:Apolipoprotein E3 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D053327:Apolipoprotein E4 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice
chemical_list: D053318:Apolipoprotein E3; D053327:Apolipoprotein E4
references: J Neurosci. 2000 Mar 1;20(5):2064-71
references: 10684907
references: Nat Neurosci. 2000 Mar;3(3):238-44
references: 10700255
references: Am J Geriatr Psychiatry. 2000 Summer;8(3):196-200
references: 10910416
references: J Biol Chem. 2000 Nov 24;275(47):36781-6
references: 10973974
references: Pharmacol Biochem Behav. 2000 Sep;67(1):145-50
references: 11113494
references: Psychol Med. 2001 Apr;31(3):431-40
references: 11305851
references: Alzheimer Dis Assoc Disord. 1994;8(Suppl. 1):S360-7
references: 11657168
references: Neurology. 2002 Apr 23;58(8):1182-8
references: 11971084
references: Biol Psychiatry. 2002 Jun 1;51(11):875-81
references: 12022960
references: J Neurosci. 2002 Jun 15;22(12):5204-9
references: 12077215
references: Neurology. 2002 Sep 10;59(5):746-8
references: 12221169
references: J Neuropsychiatry Clin Neurosci. 2003 Spring;15(2):180-6
references: 12724459
references: J Gerontol Nurs. 2004 Jan;30(1):12-20
references: 14753054
references: Neuropsychopharmacology. 2004 Mar;29(3):441-9
references: 14628000
references: Rev Neurol. 2004 May 16-31;38(10):901-5
references: 15175968
references: Neurology. 2004 Jun 8;62(11):1990-5
references: 15184602
references: J Alzheimers Dis. 2004 Jun;6(3):329-36
references: 15201487
references: JAMA. 1982 Jul 16;248(3):333-5
references: 7087127
references: Br J Psychiatry. 1983 Sep;143:277-81
references: 6626841
references: Neurology. 1984 Jul;34(7):939-44
references: 6610841
references: Biol Psychiatry. 1985 Jan;20(1):86-93
references: 3965040
references: Science. 1988 Apr 29;240(4852):622-30
references: 3283935
references: Br J Psychiatry. 1991 Jan;158:64-71
references: 2015452
references: J Gerontol. 1991 Nov;46(6):P362-71
references: 1940093
references: J Lipid Res. 1991 Oct;32(10):1611-8
references: 1665849
references: Mol Endocrinol. 1992 Feb;6(2):288-98
references: 1373819
references: Life Sci. 1993;53(22):1675-83
references: 8231648
references: J Neurol Neurosurg Psychiatry. 1996 Jun;60(6):644-9
references: 8648331
references: Neurology. 1996 Jul;47(1):256-9
references: 8710089
references: Methods Find Exp Clin Pharmacol. 1996 Jan-Feb;18(1):19-24
references: 8721252
references: Brain Behav Immun. 1996 Jun;10(2):115-25
references: 8811935
references: J Neural Transm Suppl. 1996;47:205-18
references: 8841967
references: J Clin Endocrinol Metab. 1997 Oct;82(10):3251-9
references: 9329348
references: JAMA. 1997 Oct 22-29;278(16):1349-56
references: 9343467
references: Mol Neurobiol. 1998 Aug;18(1):1-22
references: 9824846
references: Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15049-54
references: 9844013
references: Biol Psychiatry. 1999 Feb 15;45(4):422-5
references: 10071711
references: Am J Geriatr Psychiatry. 1999 Spring;7(2):119-23
references: 10322238
references: Neurobiol Aging. 2005 May;26(5):637-43
references: 15708438