title: Sarcomas: genetics, signalling, and cellular origins. Part 2: TET-independent fusion proteins and receptor tyrosine kinase mutations.
abstract: Although the mechanisms that underlie sarcoma development are still poorly understood, the identification of non-random chromosomal translocations and receptor tyrosine kinase mutations associated with defined sarcoma types has provided new insight into the pathogenesis of these tumours. In Part 1 of the review (J Pathol 2007;213:4-20), we addressed sarcomas that express fusion genes containing TET gene family products. Part 2 of the review summarizes our current understanding of the implications of fusion genes that do not contain TET family members in sarcoma development, as well as that of specific mutations in genes encoding receptor tyrosine kinases (RTKs). The final section will serve as a summary of both reviews and will attempt to provide a synthesis of some of the emerging principles of sarcomagenesis.
authors: Division of Experimental Pathology, Institute of Pathology, University of Lausanne, Lausanne, Switzerland.
authors: M-L
authors: ML
authors: Suvà
authors: L
authors: L
authors: Cironi
authors: N
authors: N
authors: Riggi
authors: I
authors: I
authors: Stamenkovic
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D006801:Humans; D009154:Mutation; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D012509:Sarcoma / Q000235:genetics* / Q000503:physiopathology; D015398:Signal Transduction; D014178:Translocation, Genetic
chemical_list: D015514:Oncogene Proteins, Fusion; D020794:Receptor Protein-Tyrosine Kinases