Geminal bismethylation prevents polyketide oxidation and dimerization in the benastatin pathway.
Schenk
Angéla
A
Dept. of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstrasse 11a, 07745 Jena, Germany.
Xu
Zhongli
Z
Pfeiffer
Corina
C
Steinbeck
Christoph
C
Hertweck
Christian
C
D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism; D019281:Dimerization; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors; D018942:Macrolides / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D009279:Naphthacenes / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D048170:Streptomyces lividans / Q000737:chemistry
D000970:Antineoplastic Agents; D018942:Macrolides; D009279:Naphthacenes; C077629:benastatin A; D005982:Glutathione Transferase