Genetically modified crops for the bioeconomy: meeting public and regulatory expectations.
As the United States moves toward a plant-based bioeconomy, a large research and development effort is focused on creating new feedstocks to meet biomass demand for biofuels, bioenergy, and specialized bioproducts, such as industrial compounds and biomaterial precursors. Most bioeconomy projections assume the widespread deployment of novel feedstocks developed through the use of modern molecular breeding techniques, but rarely consider the challenges involved with the use of genetically modified crops, which can include hurdles due to regulatory approvals, market adoption, and public acceptance. In this paper we consider the implications of various transgenic crops and traits under development for the bioeconomy that highlight these challenges. We believe that an awareness of the issues in crop and trait selection will allow developers to design crops with maximum stakeholder appeal and with the greatest potential for widespread adoption, while avoiding applications unlikely to meet regulatory approval or gain market and public acceptance.
Chapotin
Saharah Moon
SM
US Agency for International Development, Washington, DC 20523, USA.
Wolt
Jeffrey D
JD
D000818:Animals; D018556:Crops, Agricultural / Q000191:economics / Q000235:genetics* / Q000592:standards; D030841:Food, Genetically Modified / Q000191:economics / Q000592:standards; D005818:Genetic Engineering / Q000191:economics / Q000331:legislation & jurisprudence* / Q000592:standards; D006801:Humans; D030821:Plants, Genetically Modified; D011639:Public Opinion; D014481:United States
Nat Biotechnol. 2007 Mar;25(3):271
17344870
Nat Biotechnol. 2001 Sep;19(9):807-8
11533629
Nat Biotechnol. 2003 Mar;21(3):227-8
12610561
Nature. 2006 Dec 7;444(7120):670-2
17151627
Curr Opin Biotechnol. 2005 Apr;16(2):159-66
15831381
Adv Biochem Eng Biotechnol. 2005;100:1-17
16270654
Nat Biotechnol. 2006 Jul;24(7):748-9
16841049
Appl Microbiol Biotechnol. 2005 Apr;67(1):19-25
15599517
Nat Biotechnol. 2003 Jan;21(1):3-4
12511893
Trends Plant Sci. 2005 Dec;10(12):580-5
16290220
Curr Opin Biotechnol. 2005 Apr;16(2):123-32
15831376
Curr Opin Biotechnol. 2005 Apr;16(2):147-53
15831379
Trends Biotechnol. 2004 Feb;22(2):64-6
14757039
Science. 2000 Dec 15;290(5499):2088-93
11118136
Trends Plant Sci. 2004 Dec;9(12):597-605
15564127
Trends Biotechnol. 2006 Mar;24(3):109-14
16460821
Trends Plant Sci. 2003 Dec;8(12):576-81
14659706
Trends Biotechnol. 2003 Dec;21(12):570-8
14624867
Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14533-8
15448206
Curr Opin Biotechnol. 2006 Apr;17(2):113-22
16495045
Philos Trans R Soc Lond B Biol Sci. 2003 Jun 29;358(1434):1163-70
12831483
EMBO Rep. 2001 Jun;2(6):455-9
11415971
Curr Opin Biotechnol. 2006 Apr;17(2):105-12
16483761
Nat Biotechnol. 2006 Jul;24(7):725
16841037
Nat Biotechnol. 2004 Feb;22(2):133
14755274
Risk Anal. 2006 Jun;26(3):845-58
16834638
Nat Biotechnol. 2002 Jun;20(6):581-6
12042861
Nat Biotechnol. 2003 Apr;21(4):366-9
12665818
Nat Biotechnol. 2005 May;23(5):514
15877056
Science. 2006 Dec 8;314(5805):1598-600
17158327
Science. 2006 Jan 27;311(5760):484-9
16439654
Nat Biotechnol. 2007 Mar;25(3):283-4
17344874
Nat Biotechnol. 2005 Apr;23(4):439-44
15815671
Plant Biotechnol J. 2004 Sep;2(5):431-8
17168889
Nat Biotechnol. 2006 Jul;24(7):755-60
16841053
Nat Biotechnol. 1999 Aug;17(8):808-12
10429249
Nat Rev Genet. 2003 Oct;4(10):806-17
14526376
Science. 2003 Apr 4;300(5616):61-2
12677045
Science. 2006 Jan 27;311(5760):435
16439624
Plant Cell Rep. 2004 May;22(10):711-20
14997337
Nat Biotechnol. 2004 Jun;22(6):671-5
15175684
Science. 2007 Feb 9;315(5813):804-7
17289988
Plant Physiol. 2003 Aug;132(4):1770-4
12913134
Trends Plant Sci. 2005 Nov;10(11):511-2
16213779
Plant Cell Environ. 2006 Mar;29(3):315-30
17080588
Science. 2006 Jan 27;311(5760):506-8
16439656