title: Fatty acid amide hydrolase: from characterization to therapeutics.
abstract: Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme within the amidase-signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. The hydrolysis of such messengers leads to molecules devoid of biological activity, and, therefore, modulates a number of neurobehavioral processes in mammals, including pain, sleep, feeding, and locomotor activity. Investigations into the structure and function of FAAH, its biological and therapeutic implications, as well as a description of different families of FAAH inhibitors are the topic of this review.
authors: Unité de Chimie pharmaceutique et de Radiopharmacie, Ecole de Pharmacie, Faculté de Médecine, Université catholique de Louvain, Avenue E. Mounier 73.40, B-1200 Bruxelles.
authors: Geoffray
authors: G
authors: Labar
authors: Catherine
authors: C
authors: Michaux
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000502:physiology; D000818:Animals; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism*; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D009765:Obesity / Q000201:enzymology; D019966:Substance-Related Disorders / Q000201:enzymology; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D063385:Cannabinoid Receptor Modulators; D000099252:Fatty Acid Amide Hydrolases