Selection of donor and organ viability criteria: expanding donation criteria.
Donation criteria have been becoming more flexible over the years. Currently, the only absolute exclusion criteria are human immunodeficiency virus infection (HIV), uncontrolled tumor disease and bacterial or viral infections. ClinicaL. conditions dictate organ viability criteria: biochemical, morphological and functional, that must be fulfilled by the donors and their organs in order to focus the decision on which donor organs can be used. These criteria attempt to assure that the transplanted organs function after the extraction, transformation, implantation and reperfusion process without transmitting any infectious or tumour disease. In recent years, the gross and microscopic appearance has become one of the fundamental criteria for selection of potentially viable organs. At present, there is no age limit for hepatic and renal donation; the principal contra-indication is chronic organ damage. The use of each organ must be decided individually after a profound analysis of all the viability criteria, weighing the advantages and disadvantages of the implant of a certain organ for the recipient.
Gutiérrez
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Nephrology Department, Hospital 12 de Octubre, Madrid, Spain. eduardogm90@hotmail.com
Andrés
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D000367:Age Factors; D000465:Algorithms; D002908:Chronic Disease; D000075202:Contraindications; D003663:Decision Trees; D046148:Donor Selection / Q000379:methods* / Q000592:standards; D006321:Heart / Q000502:physiology; D006323:Heart Arrest / Q000150:complications; D006801:Humans; D017053:Infection Control / Q000379:methods; D016030:Kidney Transplantation / Q000009:adverse effects; D008099:Liver / Q000502:physiology; D019520:Living Donors; D008168:Lung / Q000502:physiology; D009926:Organ Preservation; D010179:Pancreas / Q000502:physiology; D014022:Tissue Survival / Q000502:physiology; D009927:Tissue and Organ Procurement