title: Recent genetic selection in the ancestral admixture of Puerto Ricans.
abstract: Recent studies have used dense markers to examine the human genome in ancestrally homogeneous populations for hallmarks of selection. No genomewide studies have focused on recently admixed groups--populations that have experienced admixing among continentally divided ancestral populations within the past 200-500 years. New World admixed populations are unique in that they represent the sudden confluence of geographically diverged genomes with novel environmental challenges. Here, we present a novel approach for studying selection by examining the genomewide distribution of ancestry in the genetically admixed Puerto Ricans. We find strong statistical evidence of recent selection in three chromosomal regions, including the human leukocyte antigen region on chromosome 6p, chromosome 8q, and chromosome 11q. Two of these regions harbor genes for olfactory receptors. Interestingly, all three regions exhibit deficiencies in the European-ancestry proportion.
authors: Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
authors: Hua
authors: H
authors: Tang
authors: Shweta
authors: S
authors: Choudhry
authors: Rui
authors: R
authors: Mei
authors: Martin
authors: M
authors: Morgan
authors: William
authors: W
authors: Rodriguez-Cintron
authors: Esteban González
authors: EG
authors: Burchard
authors: Neil J
authors: NJ
authors: Risch
mesh_terms: D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D015894:Genome, Human / Q000235:genetics; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012641:Selection, Genetic; D014481:United States / Q000208:ethnology
references: Genetics. 1991 Feb;127(2):417-28
references: 2004712
references: Am J Hum Genet. 2003 Sep;73(3):489-501
references: 12908129
references: Genome Res. 2005 Nov;15(11):1553-65
references: 16251465
references: Am J Public Health. 2005 Dec;95(12):2161-8
references: 16257940
references: Am J Hum Genet. 2000 Mar;66(3):969-78
references: 10712211
references: Genetics. 2006 Aug;173(4):2121-42
references: 16702436
references: Am J Hum Genet. 2006 Jul;79(1):1-12
references: 16773560
references: Transplant Proc. 2002 Dec;34(8):3075-8
references: 12493379
references: Science. 1973 Jun 15;180(4091):1137-43
references: 4707061
references: Genet Epidemiol. 2005 May;28(4):289-301
references: 15712363
references: Science. 1969 Aug 22;165(3895):762-8
references: 4894336
references: PLoS Biol. 2006 Mar;4(3):e72
references: 16494531
references: Am J Respir Crit Care Med. 2004 Feb 1;169(3):386-92
references: 14617512
references: Hum Genet. 2006 Jan;118(5):652-64
references: 16283388
references: Forensic Sci Int. 2006 Dec 20;164(2-3):266-70
references: 16426785
references: Am J Hum Genet. 1963 Dec;15:429-37
references: 14097237
references: Nat Genet. 2007 Jan;39(1):31-40
references: 17159977
references: Nature. 2002 Oct 24;419(6909):832-7
references: 12397357
references: Biochem Biophys Res Commun. 2003 Sep 12;309(1):143-54
references: 12943675
references: Proc Natl Acad Sci U S A. 1955 Mar 15;41(3):144-50
references: 16589632
references: Nat Biotechnol. 2003 Oct;21(10):1233-7
references: 12960966