[Experience in postoperative sedation with dexmedetomidine for mandibular osteotomy].
BACKGROUND
Dexmedetomidine may be suitable for postoperative sedation of patients with mandibular osteotomy.


METHODS
Twenty patients were sedated with dexmedetomidine (group D) employing loading infusion at 1.0 microg x kg(-) x hr(-1) and then continuous infusion at 0.7 mg x kg(-1) x hr(-1). Other twenty patients were sedated with midazolam 0.1 mg x kg(-1) (group C). Ramsay score was recorded at 3 hours and 12 hours after infusing sedative drugs. Then, we questioned patients, nurses and doctors.


RESULTS
Ramsay score in the group D was higher than that in the group C (P < 0.01). Hypotension and respiratory depression did not occur. But bradycardia occurred in two cases. By adding propofol, group D showed more effective sedation.


CONCLUSIONS
This study shows that sedation with dexmedetomidine is more suitable than that with midazolam.
Maeda
Miho
M
Department of Anesthesiology, University of Tokai School of Medicine, Isehara 259-1193.
Fukuyama
Haruo
H
Ando
Satoko
S
Suzuki
Toshiyasu
T
D000293:Adolescent; D000328:Adult; D002648:Child; D016292:Procedural Sedation; D020927:Dexmedetomidine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008334:Mandible / Q000601:surgery*; D008874:Midazolam; D010027:Osteotomy; D011182:Postoperative Care; D015742:Propofol / Q000008:administration & dosage
D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D008874:Midazolam; D015742:Propofol