title: Mammalian mitochondrial nucleoids: organizing an independently minded genome.
abstract: Mitochondrial DNA is arranged in nucleoprotein complexes, or nucleoids. Nucleoid proteins include not only factors involved in replication and transcription but also structural proteins required for mitochondrial DNA maintenance. Although several nucleoid proteins have been identified and characterized in yeast over the course of the past decade, little was known of mammalian mitochondrial nucleoids until recently. Two publications in the past year have expanded considerably the pool of putative mammalian mitochondrial nucleoid proteins; and analysis of one of the candidates, ATAD3p, suggests that mitochondrial nucleoid formation and division are orchestrated, not random, events.
authors: MRC-Dunn Human Nutrition Unit, Wellcome Trust-MRC Building, Hills Road, Cambridge CB2 OXY, UK. ih@mrc-dunn.cam.ac.uk
authors: Ian J
authors: IJ
authors: Holt
authors: Jiuya
authors: J
authors: He
authors: Chih-Chieh
authors: CC
authors: Mao
authors: Jerome D
authors: JD
authors: Boyd-Kirkup
authors: Peter
authors: P
authors: Martinsson
authors: Hiroshi
authors: H
authors: Sembongi
authors: Aurelio
authors: A
authors: Reyes
authors: Johannes N
authors: JN
authors: Spelbrink
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities; D000251:Adenosine Triphosphatases; D000818:Animals; D002478:Cells, Cultured; D004261:DNA Replication / Q000502:physiology; D004272:DNA, Mitochondrial / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins; D008928:Mitochondria / Q000502:physiology*; D028361:Mitochondrial Diseases / Q000503:physiopathology; D051336:Mitochondrial Membranes / Q000502:physiology; D024101:Mitochondrial Proteins; D009698:Nucleoproteins / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000648:ultrastructure
chemical_list: C549686:ATAD3A protein, human; C519737:ATAD3B protein, human; D004272:DNA, Mitochondrial; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D009698:Nucleoproteins; D000251:Adenosine Triphosphatases; D000074183:ATPases Associated with Diverse Cellular Activities