Accumbal dopamine D2 receptors are important for sensorimotor gating in C3H mice.
One operational measure of sensorimotor gating that is deficient in many psychiatric disorders is prepulse inhibition (PPI) of the startle response. To investigate the role of dopamine D1 and D2 receptors within the nucleus accumbens (NAC) in sensorimotor gating in mice, we infused dopamine D1 and D2 receptor agonists (dihydrexidine and quinpirole respectively) directly into the NAC and measured the effects on PPI and on prepulse facilitation. Quinpirole infusions increased PPI and attenuated prepulse facilitation, whereas dihydrexidine had no effects. These results stand in contrast to data after systemic injections in mice and rats and intra-accumbal infusions in rats, suggesting that the role of dopamine D2 receptors within the NAC in mice differs from their role in rats.
Mohr
Daniela
D
Animal Physiology, University of Tübingen, Auf der Morgenstelle Tübingen, Germany.
Pilz
Peter K D
PK
Plappert
Claudia F
CF
Fendt
Markus
M
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D018491:Dopamine Agonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D008124:Locomotion / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D010617:Phenanthridines / Q000494:pharmacology; D019257:Quinpirole / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D013216:Reflex, Startle / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D018491:Dopamine Agonists; D010617:Phenanthridines; D017448:Receptors, Dopamine D2; D019257:Quinpirole; C061532:dihydrexidine