The transient receptor potential vanilloid-responsive 1 and 4 cation channels: role in neuronal osmosensing and renal physiology.
OBJECTIVE
To provide an overview of recent developments in the field of systemic osmoregulation, with attention to the brain and kidney.


RESULTS
A number of pivotal observations underscore the primary importance of transient receptor potential channels in systemic osmoregulation and their involvement constitutes the focus of this review. Recent data suggest that transient receptor potential vanilloid-responsive 4 is a central sensor or effector of systemic hypotonicity, whereas an unidentified variant of transient receptor potential vanilloid-responsive 1 potentially serves an analogous role in systemic hypertonicity.


CONCLUSIONS
Members of the transient receptor potential vanilloid-responsive subfamily of transient receptor potential channels are likely to serve as central sensors of systemic anisotonicity.
Cohen
David M
DM
Nephrology Section, Portland Veterans Affairs Medical Center and Division of Nephrology and Hypertension, Department of Medicine, Oregon Health & Science University, Portland, Oregon 97239, USA. cohend@ohsu.edu
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D006955:Hypernatremia / Q000473:pathology; D006973:Hypertension / Q000473:pathology; D007022:Hypotension; D007668:Kidney / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D050916:TRPV Cation Channels / Q000378:metabolism / Q000502:physiology*; D014882:Water-Electrolyte Balance
D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; C416986:TRPV4 protein, human