title: A neuroprosthesis for restoring sight.
abstract: Macular degeneration (MD) and retinitis pigmentosa (RP), two diseases that cause degeneration of retinal photoreceptor cells, are the leading causes of blindness in the United States. Anatomical studies have shown that other retinal neuronal cells (bipolar cells, ganglion cells) are preserved in these diseases and they are capable of eliciting visual percepts when electrically stimulated. We describe the design of a prototype 16-electrode retinal prosthesis, and the physiological and clinical results on six blind patients with RP who had the device implanted. The US Department of Energy artificial retina program is described. The goal of the program is construction of a 1000-electrode retinal neuroprosthesis with the potential of enabling blind patients to read large print and ambulate with ease.
authors: Office of Biological and Environmental Sciences, United States Department of Energy, Germantown, MD, USA.
authors: M V
authors: MV
authors: Viola
authors: A A
authors: AA
authors: Patrinos
mesh_terms: D000818:Animals; D001766:Blindness / Q000209:etiology / Q000628:therapy*; D004599:Electric Stimulation Therapy / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008268:Macular Degeneration / Q000150:complications; D009474:Neurons / Q000502:physiology*; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000295:instrumentation / Q000379:methods*; D020127:Recovery of Function / Q000502:physiology*; D012160:Retina / Q000473:pathology; D012174:Retinitis Pigmentosa / Q000150:complications