title: Innate immune evasion by hepatitis C virus and West Nile virus.
abstract: Antiviral immunity in mammals involves several levels of surveillance and effector actions by host factors to detect viral pathogens, trigger alpha/beta interferon production, and to mediate innate defenses within infected cells. Our studies have focused on understanding how these processes are regulated during infection by hepatitis C virus (HCV) and West Nile virus (WNV). Both viruses are members of the Flaviviridae and are human pathogens, but they each mediate a very different disease and course of infection. Our results demonstrate common and unique innate immune interactions of each virus that govern antiviral immunity and demonstrate the central role of alpha/beta interferon immune defenses in controlling the outcome of infection.
authors: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
authors: Brian C
authors: BC
authors: Keller
authors: Cynthia L
authors: CL
authors: Johnson
authors: Andrea Kaup
authors: AK
authors: Erickson
authors: Michael
authors: M
authors: Gale
mesh_terms: D000818:Animals; D016174:Hepacivirus / Q000472:pathogenicity*; D006801:Humans; D007113:Immunity, Innate; D007372:Interferons / Q000276:immunology*; D014902:West Nile virus / Q000472:pathogenicity*
chemical_list: D007372:Interferons
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