Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction.
BACKGROUND
Pregnancy-associated plasma protein-A (PAPP-A) is a high-molecular-weight, zinc-binding matrix metalloproteinase that is known to be abundantly expressed in ruptured plaques. Previous studies have shown PAPP-A to be a significant marker of plaque instability and cardiovascular events in patients with acute coronary syndromes. Because the activity of PAPP-A may be modulated by genetic variants in the PAPP-A genes, we tried to determine the association of PAPP-A gene with acute myocardial infarction (AMI).


METHODS
We analyzed four single nucleotide polymorphisms (SNPs) of PAPP-A gene variants and seven other polymorphisms of cytokine genes that have been reported to have functional significance (RANTES G-403A, MCP1 G-2518A, CRP A2147G, CRP G-717A, AGER G557A, LTA T26A, IL-6 G-572C) for possible association with AMI in 170 unrelated AMI patients and unrelated age-matched controls, respectively.


RESULTS
The average age of the study population was 62.2+/-11.4 years in AMI patients and 62.6+/-10.4 years in healthy controls. Multiple logistic regression analysis with risk factors such as age, male sex, smoking, hypertension, diabetes mellitus, and dyslipidemia revealed the PAPP-A IVS6+95 C allele to be associated with an increased risk of AMI (dominancy: odds ratio, 2.13; 95% confidence interval, 1.12-4.07; P=0.022; codominancy: odds ratio, 1.89; 95% confidence interval, 1.14-3.16; P=0.015).


CONCLUSIONS
We found, for the first time, that PAPP-A IVS6+95 C allele is an independent risk factor for AMI even after adjustment for traditional risk factors. The determination of such genotype contributing to AMI could provide a new tool for identifying high-risk individuals.
Park
Sungha
S
Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Shinchon-Dong, Seodaemun-Ku, Seoul, Republic of Korea.
Youn
Jong-Chan
JC
Shin
Dong-Jik
DJ
Park
Chan-Mi
CM
Kim
Jung-Sun
JS
Ko
Young-Guk
YG
Choi
Donghoon
D
Ha
Jong-Won
JW
Jang
Yangsoo
Y
Chung
Namsik
N
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011266:Pregnancy-Associated Plasma Protein-A / Q000235:genetics*; D012307:Risk Factors
D011266:Pregnancy-Associated Plasma Protein-A