title: Depression in Parkinson's disease. Diffusion tensor imaging study.
abstract: OBJECTIVE
  The pathophysiology of depression and anxiety in Parkinson's disease remains obscure. We aimed to compare the fractional anisotropy (FA) values of Parkinson's disease (PD) patients with and without depression to investigate the nature of depression in PD.
  
  
  METHODS
  Twenty-eight patients were divided into two groups: those with depression and those without. Diagnosis of depression was made using the DSM-IV criteria. Patients in the two groups were matched for Hoehn Yahr stage.
  
  
  RESULTS
  There were significant reductions in FA values in the bilateral frontal ROIs possibly representing anterior cingulate bundles.
  
  
  CONCLUSIONS
  The anterior cingulate bundles play an important role in depression in PD, and some aspects of depression in PD have pathological processes in common with de novo depression.
authors: Dept. of Neurology, Sumitomo Hospital, 5-3-20 Nakanoshima, Osaka 530-0005, Japan. hide0729@Kuhp.Kyoto-u.ac.jp
authors: Hideaki
authors: H
authors: Matsui
authors: Kazuto
authors: K
authors: Nishinaka
authors: Masaya
authors: M
authors: Oda
authors: Hidekazu
authors: H
authors: Niikawa
authors: Kenichi
authors: K
authors: Komatsu
authors: Tamotsu
authors: T
authors: Kubori
authors: Fukashi
authors: F
authors: Udaka
mesh_terms: D000368:Aged; D016880:Anisotropy; D003866:Depressive Disorder / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology; D006179:Gyrus Cinguli / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*
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