Functional sex differences in human primary auditory cortex.
BACKGROUND
We used PET to study cortical activation during auditory stimulation and found sex differences in the human primary auditory cortex (PAC). Regional cerebral blood flow (rCBF) was measured in 10 male and 10 female volunteers while listening to sounds (music or white noise) and during a baseline (no auditory stimulation).


CONCLUSIONS
We found a sex difference in activation of the left and right PAC when comparing music to noise. The PAC was more activated by music than by noise in both men and women. But this difference between the two stimuli was significantly higher in men than in women. To investigate whether this difference could be attributed to either music or noise, we compared both stimuli with the baseline and revealed that noise gave a significantly higher activation in the female PAC than in the male PAC. Moreover, the male group showed a deactivation in the right prefrontal cortex when comparing noise to the baseline, which was not present in the female group. Interestingly, the auditory and prefrontal regions are anatomically and functionally linked and the prefrontal cortex is known to be engaged in auditory tasks that involve sustained or selective auditory attention. Thus we hypothesize that differences in attention result in a different deactivation of the right prefrontal cortex, which in turn modulates the activation of the PAC and thus explains the sex differences found in the activation of the PAC.


CONCLUSIONS
Our results suggest that sex is an important factor in auditory brain studies.
Ruytjens
Liesbet
L
Department of Otorhinolaryngology, University Medical Center Groningen, Groningen, The Netherlands. l.ruytjens@umcutrecht.nl
Georgiadis
Janniko R
JR
Holstege
Gert
G
Wit
Hero P
HP
Albers
Frans W J
FW
Willemsen
Antoon T M
AT
D000161:Acoustic Stimulation / Q000379:methods*; D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D012737:Sex Factors
Brain Cogn. 1998 Jul;37(2):254-85
9665746
Cereb Cortex. 1998 Jul-Aug;8(5):397-406
9722083
Psychoneuroendocrinology. 1998 Jul;23(5):519-47
9802126
J Comp Neurol. 1999 Jan 11;403(2):141-57
9886040
Brain. 1999 Feb;122 ( Pt 2):199-208
10071049
Neuroimage. 2005 May 1;25(4):1325-35
15850749
Neuropsychology. 2005 Jul;19(4):509-19
16060826
AJNR Am J Neuroradiol. 2005 Oct;26(9):2248-55
16219830
Neuroimage. 2006 Mar;30(1):245-53
16253520
Eur J Neurosci. 2006 Sep;24(6):1835-44
17004947
Acta Otolaryngol. 2006 Dec;126(12):1236-44
17101583
Int J Psychophysiol. 2007 Feb;63(2):192-8
16797758
Audiol Neurootol. 2007;12(6):371-7
17664868
Nat Neurosci. 1999 Dec;2(12):1131-6
10570492
Neuropsychologia. 2000;38(3):304-12
10678696
Cereb Cortex. 2000 Sep;10(9):866-72
10982747
Annu Rev Neurosci. 2001;24:167-202
11283309
Neuroimage. 2001 Apr;13(4):669-83
11305896
Neuroimage. 2001 Apr;13(4):684-701
11305897
Neuroreport. 2001 Jun 13;12(8):1561-5
11409716
Neuroimage. 2001 Sep;14(3):685-700
11506541
Neurosci Lett. 2001 Nov 16;314(3):131-4
11704301
Nat Neurosci. 2002 Jan;5(1):15-6
11753413
Neurosci Res. 2001 Dec;41(4):333-7
11755219
Neuroimage. 2002 Apr;15(4):870-8
11906227
Eur J Neurosci. 2002 Jul;16(2):291-310
12169111
Neuroimage. 2002 Sep;17(1):142-60
12482073
Neuroimage. 2002 Dec;17(4):1844-53
12498758
J Comp Neurol. 2003 Jun 2;460(3):425-49
12692859
Int J Psychophysiol. 2003 Jun;48(3):285-92
12798988
Neuroimage. 2003 Jul;19(3):895-905
12880818
Neuropsychologia. 2003;41(14):1899-911
14572523
Neuroimage. 2004 Jul;22(3):1107-16
15219582
Brain. 2004 Aug;127(Pt 8):1845-52
15240433
Ann Neurol. 1978 Oct;4(4):345-56
727739
Neuroscience. 1985 Jul;15(3):619-37
4069349
Hear Res. 1993 Aug;68(2):143-51
8407600
Cereb Cortex. 1994 Mar-Apr;4(2):107-18
8038562
J Clin Exp Neuropsychol. 1994 Jun;16(3):423-35
7929710
J Clin Exp Neuropsychol. 1995 Aug;17(4):590-610
7593478
Biol Psychiatry. 1996 Jan 1;39(1):51-8
8719126
Cereb Cortex. 1996 Sep-Oct;6(5):661-72
8921202
Arch Neurol. 1997 Feb;54(2):171-6
9041858
Neuroimage. 1997 Jan;5(1):63-77
9038285
Audiol Neurootol. 1998 Mar-Jun;3(2-3):73-85
9575378