Antifungal rosane diterpenes and other constituents of Hugonia castaneifolia.
The rosane diterpenoids hugorosenone [3beta-hydroxyrosa-1(10),15-dien-2-one], 18-hydroxyhugorosenone and 18-hydroxy-3-deoxyhugorosenone, and 12-hydroxy-13-methylpodocarpa-8,11,13-trien-3-one were isolated as antifungal constituents of H. castaneifolia Engl. root bark, together with the previously reported di-podocarpanoids hugonone A and hugonone B that were weakly active, and 1(10),15-rosadiene-2beta,3beta-diol (hugorosenol), 4alpha-methoxyhimachal-10-en-5beta-ol (hugonianene B) and 2-hydroxyhenpentacont-2-enal, and the known compounds tetracosyl-(E)-ferrulate and caryophyllene oxide, all of which were inactive. Hugorosenone also exhibited activity against Anopheles gambiae mosquito larvae. Structural determination was achieved based on spectroscopic data.
Baraza
Lilechi D
LD
Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania.
Joseph
Cosam C
CC
Munissi
Joan J E
JJ
Nkunya
Mayunga H H
MH
Arnold
Norbert
N
Porzel
Andrea
A
Wessjohann
Ludger
L
D000818:Animals; D000852:Anopheles / Q000187:drug effects / Q000254:growth & development; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D002963:Cladosporium / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D019658:Linaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy
D000935:Antifungal Agents; D004224:Diterpenes