[123I]FP-CIT striatal binding in early Parkinson's disease patients with tremor vs. akinetic-rigid onset.
We performed [123I]FP-CIT/SPECT in 20 drug-naive Parkinson's disease (PD) patients, 10 with unilateral akinesia/rigidity at onset (arPD) and 10 with additional tremor-at-rest (tPD), to evaluate whether resting tremor at onset is associated with differences in striatal dopamine transporter binding. Patients of the two cohorts were matched for age, disease duration (<3 years) and severity of non-tremor motor symptoms; 31 healthy participants served as controls. Mean striatal dopamine transporter binding reduction in PD patients vs. controls was 42% for arPD and 50% for tPD; mean ipsilateral striatum and caudate nucleus uptake values were lower by 12 and 24%, respectively, in tPD than arPD. We conclude that widespread degeneration of the nigrostriatal dopaminergic pathway might be necessary for the development of parkinsonian tremor-at-rest.
Isaias
Ioannis U
IU
Parkinson Institute, Istituti Clinici di Perfezionamento, Milan 20126, Italy.
Benti
Riccardo
R
Cilia
Roberto
R
Canesi
Margherita
M
Marotta
Giorgio
G
Gerundini
Paolo
P
Pezzoli
Gianni
G
Antonini
Angelo
A
D000368:Aged; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D010300:Parkinson Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon; D014202:Tremor / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D014326:Tropanes / Q000493:pharmacokinetics*
D007457:Iodine Radioisotopes; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane