title: Determination of lipophilicity and pKa measurement of some 4-imino-1,4-dihydrocinnoline-3-carboxylic acid and 4-oxo-1,4-dihydrocinnoline-3-carboxylic acid derivatives--isosteric analogues of quinolones.
abstract: As a continuation of our study, physicochemical properties of some antibacterial active 4-imino-1,4-dihydrocinnoline-3-carboxylic acid and 4-oxo-1,4-dihydrocinnoline-3-carboxylic acid derivatives were investigated. Partition coefficient (log P), and dissociation constant (pKa) were experimentally determined and also calculated by the use of ACDLabs system software. The obtained values were correlated with experimental data.
authors: Department of Hospital Pharmacy, Medical University of Lódź, Muszyńskiego 1, 90-151 Lódź, Poland.
authors: Wiesława
authors: W
authors: Lewgowd
authors: Andrzej
authors: A
authors: Stańczaka
authors: Zbigniew
authors: Z
authors: Ochocki
authors: Krystyna
authors: K
authors: Rzeszowska-Modzelewska
mesh_terms: D042462:4-Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002855:Chromatography, Thin Layer; D057927:Hydrophobic and Hydrophilic Interactions; D008826:Microbial Sensitivity Tests; D000442:Octanols / Q000737:chemistry; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D000442:Octanols; D014867:Water