Regiospecific solid-phase strategy to N7-substituted purines and its application to 8-azapurines and [I]-condensed purines.
A highly regioselective and traceless solid-phase route to 1,7,8-trisubstituted purines has been developed. This methodology could be extended to the preparation of 8-azapurines and [i]-condensed purines. A representative set of 17 purines, azapurines, and [i]-condensed purines was synthesized. This paper also describes a mild method to prepare the p-benzyloxybenzylamine (BOBA) resin.
Fu
Han
H
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Tan
Mark Kheng Chuan
MK
Lam
Yulin
Y
D006898:Hydroxylamines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011687:Purines / Q000737:chemistry*
D006898:Hydroxylamines; D011687:Purines; C015008:triazolopyrimidinone; C017064:benzyloxyamine