title: Acceleration of allograft failure by cytomegalovirus.
abstract: A number of human herpesviruses are important opportunistic pathogens that have been associated with increased morbidity and mortality in transplant recipients including human cytomegalovirus (HCMV), HHV6, HHV7, HHV8 as well as HSV-1, VZV. However, HCMV has been linked both epidemiologically and through the use of animal models to the acceleration of acute and chronic allograft rejection. This review will cover the pathophysiology, epidemiology, and mechanisms of CMV-associated disease in the setting of transplantation.
authors: MMI, OHSU, Portland, OR, United States.
authors: Daniel N
authors: DN
authors: Streblow
authors: Susan L
authors: SL
authors: Orloff
authors: Jay A
authors: JA
authors: Nelson
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D006084:Graft Rejection / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D006801:Humans
chemical_list: D016207:Cytokines
references: Microbiol Immunol. 1997;41(2):121-9
references: 9087954
references: J Virol. 1998 Oct;72(10):8158-65
references: 9733857
references: J Infect Dis. 1999 Feb;179(2):484-8
references: 9878035
references: Transplantation. 1999 Jan 15;67(1):137-44
references: 9921810
references: Biochem Biophys Res Commun. 1999 Mar 24;256(3):608-13
references: 10080946
references: Circulation. 1999 Jul 6;100(1):61-6
references: 10393682
references: J Gen Virol. 2005 Jan;86(Pt 1):23-30
references: 15604428
references: J Interferon Cytokine Res. 2004 Oct;24(10):611-20
references: 15626158
references: Am J Transplant. 2005 Mar;5(3):436-42
references: 15707397
references: Cell. 1999 Nov 24;99(5):511-20
references: 10589679
references: Transplantation. 1999 Nov 27;68(10):1568-73
references: 10589956
references: Intervirology. 1999;42(5-6):357-64
references: 10702718
references: Transplantation. 2000 Apr 15;69(7):1295-303
references: 10798744
references: Blood. 2001 Jan 15;97(2):388-92
references: 11154213
references: Rev Med Virol. 2001 Mar-Apr;11(2):73-81
references: 11262526
references: Rev Med Virol. 2001 Mar-Apr;11(2):83-6
references: 11262527
references: Transplant Proc. 2001 Feb-Mar;33(1-2):1801
references: 11267518
references: J Infect Dis. 2001 Nov 1;184(9):1109-13
references: 11598832
references: J Infect Dis. 2002 Feb 1;185(3):273-82
references: 11807708
references: Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2836-41
references: 11867723
references: Transplantation. 2002 Mar 15;73(5):679-88
references: 11907411
references: Cochrane Database Syst Rev. 2006;(1):CD005133
references: 16437521
references: J Immunol. 2006 Feb 15;176(4):2625-34
references: 16456025
references: Thorac Cardiovasc Surg. 2006 Jun;54(4):219-26
references: 16755441
references: J Gen Virol. 2006 Oct;87(Pt 10):2849-58
references: 16963742
references: Circulation. 2006 Oct 10;114(15):1608-15
references: 17015794
references: Transplant Proc. 2006 Dec;38(10):3214-20
references: 17175227
references: J Virol. 2007 Apr;81(8):3816-26
references: 17251289
references: J Clin Microbiol. 2007 Jun;45(6):1804-10
references: 17409205
references: Pediatr Transplant. 2002 Apr;6(2):111-8
references: 12000465
references: J Virol. 2003 Feb;77(3):2182-94
references: 12525653
references: J Am Soc Nephrol. 2003 Mar;14(3):780-5
references: 12595516
references: Transplant Proc. 2003 Mar;35(2):804-5
references: 12644146
references: Am J Transplant. 2003 Apr;3(4):445-51
references: 12694067
references: Microbes Infect. 2004 Jan;6(1):17-24
references: 14738889
references: Transplantation. 2004 May 15;77(9):1405-11
references: 15167599
references: Kidney Int. 2004 Jul;66(1):329-37
references: 15200441
references: J Virol. 2004 Aug;78(15):8382-91
references: 15254210
references: Microbes Infect. 2004 Oct;6(12):1056-62
references: 15380774
references: Lancet. 1983 Sep 17;2(8351):644-7
references: 6136795
references: JAMA. 1989 Jun 23-30;261(24):3561-6
references: 2542633
references: J Heart Lung Transplant. 1991 Jan-Feb;10(1 Pt 1):45-9
references: 2007170
references: Am J Pathol. 1992 Mar;140(3):739-47
references: 1312309
references: N Engl J Med. 1992 Apr 30;326(18):1182-6
references: 1313549
references: Transplantation. 1993 Apr;55(4):752-6; discussion 756-7
references: 8475548
references: Transplantation. 1994 Jan;57(1):68-72
references: 8291116
references: Science. 1994 Jul 15;265(5170):391-4
references: 8023160
references: Scand J Infect Dis Suppl. 1995;99:78-81
references: 8668947
references: J Leukoc Biol. 1997 Jan;61(1):40-9
references: 9000535
references: Transplantation. 2005 Jan 15;79(1):17-22
references: 15714164
references: Nephrol Dial Transplant. 2005 Apr;20(4):790-6
references: 15716293
references: Transplant Proc. 2005 Mar;37(2):1227-9
references: 15848677
references: Transpl Int. 2005 Jun;18(6):743-9
references: 15910304
references: Cardiovasc Res. 2005 Jul 1;67(1):151-60
references: 15949479
references: Lancet. 2005 Jun 18-24;365(9477):2105-15
references: 15964447
references: J Virol. 2005 Aug;79(16):10788-95
references: 16051870
references: J Virol. 2005 Oct;79(19):12205-17
references: 16160147
references: Transpl Int. 2005 Oct;18(10):1166-74
references: 16162104
references: Bone Marrow Transplant. 2005 Nov;36(9):813-9
references: 16151428
references: Blood. 2006 Jan 1;107(1):30-8
references: 16046529
references: Transpl Immunol. 2006 Jan;15(3):217-21
references: 16431289