Metabolic syndrome management.
Overweight, obesity and the metabolic syndrome occur in genetically susceptible individuals with environmental influences, and may be further compounded by other disorders of metabolism or pharmacological therapy that increase insulin resistance or promotes weight gain. Treatment of the metabolic syndrome should focus on treatment on [corrected] each individual component, but first, lifestyle modification, including diet and exercise with weight reduction, should be [corrected] the foundation of any successful treatment regimen for the metabolic syndrome. Pharmacological therapy should be individualized and targeted to normalize blood pressure, HDL cholesterol, triglycerides and glucose values. If successful, comprehensive management of the metabolic syndrome promises to delay or prevent the development of coronary heart disease and Type 2 diabetes mellitus.
Stone
Neil J
NJ
Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. n-stone@md.northwestern.edu
Schmeltz
Lowell R
LR
D000818:Animals; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D019468:Disease Management; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology* / Q000628:therapy*; D012307:Risk Factors