Ginkgo biloba extract prevents ethanol induced dyslipidemia.
Ginkgo biloba extract (EGB) functions as a natural substantial antioxidant and hypolipidemic. Chronic alcohol abuse leads to sustained dyslipidemia characterized by hyperlipidemia and lipid peroxidation. Thus, the present study investigates the effect of EGB on lipid disorders induced by ethanol in rats. Male Sprague-Dawley rats were fed with ethanol (2.4 g/kg), and pretreated with a daily dose of low or high EGB (48 or 96 mg/kg, respectively). During the experiment, serum was collected on day 30, 60, and 90. Serum lipid profile, including lipid peroxidation, was determined by colorimetric methods. Our data showed that ethanol intake resulted in a time-dependent increase in serum levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and malondialdehyde (MDA), and a decrease of the ratio of high-density lipoprotein cholesterol (HDL-C) against TC. EGB prophylactic medication (48 and 96 mg/kg), especially at the high dose, significantly increased HDL-C content, and normalized the abnormal lipid profile and peroxidation in comparison to ethanol-fed only rats. These results suggest that ethanol results in time-dependent hypercholesterolemia, hypertriglyceridemia and promotes serum lipid peroxidation. EGB pretreatment prevents hyperlipidemia and ameliorates lipid peroxidation induced by ethanol.
Yao
Ping
P
Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
Song
Fangfang
F
Li
Ke
K
Zhou
Shaoliang
S
Liu
Shuang
S
Sun
Xiufa
X
Nussler
Andreas K
AK
Liu
Liegang
L
D000818:Animals; D002492:Central Nervous System Depressants / Q000009:adverse effects*; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D050171:Dyslipidemias / Q000139:chemically induced / Q000517:prevention & control*; D000431:Ethanol / Q000009:adverse effects*; D020441:Ginkgo biloba; D006949:Hyperlipidemias / Q000139:chemically induced / Q000517:prevention & control; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008517:Phytotherapy / Q000379:methods; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D002492:Central Nervous System Depressants; D004365:Drugs, Chinese Herbal; D014280:Triglycerides; D000431:Ethanol; D008315:Malondialdehyde; D002784:Cholesterol