[Dura mater related Creutzfeldt-Jakob disease in Japan: relationship between sites of grafts and clinical features].
A nation wide survey demonstrated 129 case of CJD with cadaveric dura mater grafts in Japan to February 2007. These patients were identified to have received Lyodura during period between 1978 and 1991. Incubation period from grafting to the onset of symptoms varied from 16 months to 24.5 years. We conducted a retrospective review of the full medical records of 107 of these patients. Patients were divided into two groups by site of neurosurgical or orthopedic procedures (supratentorial vs. infratentorial). Hemiparesis or hemianopsia developed as an initial manifestation in 31.9% of 47 patients with supratentorial grafts but did not develop among nay of the infratentorial group (p<0.0001). Conversely, brainstem symptoms (nystagmus, diplopia, ipsilateral hearing loss, facial paresis or paresthesia) were noted in 25.0% of the infratentorial group, but were not seen in the supratentorial group (p<0.0001).
Sato
Takeshi
T
Department of Neurology, Higashi-Yamato Hospital.
Masuda
Masayuki
M
D017668:Age of Onset; D002102:Cadaver; D002353:Carrier State / Q000175:diagnosis; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission*; D018450:Disease Progression; D004388:Dura Mater / Q000637:transplantation*; D006801:Humans; D007049:Iatrogenic Disease; D007564:Japan; D011328:Prions; D012189:Retrospective Studies; D013525:Surgical Instruments / Q000009:adverse effects; D065227:Transfusion Reaction
D011328:Prions