[To be or not to be a Treg: epigenetic regulation of Foxp3 expression in regulatory T cells].
Regulatory T cells (Treg) harbor great therapeutic potential for the treatment of autoimmune diseases due to their potent suppressive capacity. The majority of these cells express the transcription factor Foxp3, which is critical for both development and function of Treg. We discuss here our recent data indicating a contribution of epigenetic regulation for the permanent expression of Foxp3 in stable Treg a finding that is of significant importance if Treg are devised for clinical applications.
Polansky
J K
JK
Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité Universitätsmedizin Berlin, Experimentelle Immunregulation, c/o Deutsches Rheuma-Forschungszentrum, Charitéplatz 1, 10117, Berlin, Germany.
Huehn
J
J
D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D018899:CpG Islands / Q000235:genetics; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000235:genetics*; D005091:Exons / Q000235:genetics; D051858:Forkhead Transcription Factors / Q000235:genetics*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics; D014176:Protein Biosynthesis / Q000235:genetics; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D016212:Transforming Growth Factor beta
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