[Epilepsy and Sabril].
This article presents a litterature overview of the ophthalmologic secondary effects due to Sabril. First, a review of the visual field loss that can be related to Sabril treatment is presented; the epidemiological and physiopathological aspects of this visual field loss are considered based on experimental and clinical data. The link that can be established between electrophysiology and physiopathology following these data is further examined. Finally, two ophthalmologic follow-up algorithms are proposed for patients treated by Sabril, one for adults and the other for children.
Depasse
F
F
Service d'Ophtalmologie, Hôpital Erasme, Université Libre de Bruxelles, Bruxelles. fanny.depasse@erasme.ulb.ac.be
D000328:Adult; D000465:Algorithms; D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D009901:Optic Nerve Diseases / Q000139:chemically induced; D017949:Retinal Cone Photoreceptor Cells / Q000187:drug effects; D020888:Vigabatrin / Q000009:adverse effects* / Q000633:toxicity; D014786:Vision Disorders / Q000139:chemically induced; D014794:Visual Fields / Q000187:drug effects* / Q000502:physiology
D000927:Anticonvulsants; D020888:Vigabatrin