title: Magnetic resonance coronary angiography with Vasovist: in-vivo T1 estimation to improve image quality of navigator and breath-hold techniques.
abstract: The purpose of the study was to estimate T1 values of blood and myocardium after a single injection of Vasovist and to assess Vasovist for magnetic resonance coronary angiography (MRCA). For all exams 0.05 mmol/kg of Vasovist was injected. T1 values of blood and myocardium were estimated over 30 min after injection. Twelve volunteers were examined on a 1.5-T Siemens system using a SSFP sequence with incrementally increasing inversion times for T1-estimation and a breath-hold 3D IR-FLASH sequence for MRCA. Eleven examinations were performed on 1.5-T Philips system using the Look-Locker approach for T1 estimation and a whole-heart inversion-prepared, 3D SSFP sequence for MRCA. SNR, CNR and image quality were assessed. T1 values of blood (5 min: 230 ms vs. 30 min: 275 ms) and myocardium (5 min: 99 ms vs. 30 min: 130 ms) increased over time. Whereas the blood SNR (1 min: 23.6 vs. 30 min: 21.2) showed no significant differences, the blood-to-myocardium CNR (1 min: 18.1 vs. 30 min: 13.8) and the image quality (1 min: 2.9 vs. 30 min: 3.8) degraded over time. Due to long plasma half-time the T1-shortening effect of Vasovist remains effective over 30 min, which allows for multiple breath-hold or high-resolution MRCA.
authors: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany.
authors: Kai
authors: K
authors: Nassenstein
authors: Kai-Uwe
authors: KU
authors: Waltering
authors: Sebastian
authors: S
authors: Kelle
authors: Thomas
authors: T
authors: Schlosser
authors: Frank
authors: F
authors: Breuckmann
authors: Stefan
authors: S
authors: Maderwald
authors: Peter
authors: P
authors: Hunold
authors: Eike
authors: E
authors: Nagel
authors: Jörg
authors: J
authors: Barkhausen
mesh_terms: D000328:Adult; D003287:Contrast Media; D003327:Coronary Disease / Q000175:diagnosis*; D005260:Female; D005682:Gadolinium; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds; D012119:Respiration
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D005682:Gadolinium; C109932:gadofosveset trisodium
references: Am Heart J. 1979 Mar;97(3):291-7
references: 420067
references: Lancet. 2002 Jun 8;359(9322):2027-9
references: 12076573
references: Radiology. 1998 Mar;206(3):830-4
references: 9494509
references: J Am Coll Cardiol. 2000 Jul;36(1):44-50
references: 10898411
references: J Magn Reson Imaging. 1999 Nov;10(5):790-9
references: 10548790
references: Acad Radiol. 2002 May;9 Suppl 1:S127-33
references: 12019847
references: Radiology. 2005 Sep;236(3):1041-6
references: 16055693
references: Magn Reson Med. 1997 Mar;37(3):448-56
references: 9055236
references: Magn Reson Med. 2001 Apr;45(4):720-3
references: 11284003
references: Magn Reson Med. 2006 May;55(5):1186-90
references: 16572392
references: Eur Radiol. 2004 Dec;14(12):2155-62
references: 15351901
references: N Engl J Med. 1979 Jun 14;300(24):1350-8
references: 440357
references: Circulation. 2002 Oct 15;106(16):2051-4
references: 12379572
references: J Am Coll Cardiol. 1999 Aug;34(2):524-31
references: 10440168
references: Eur Radiol. 2006 Jan;16(1):1-14
references: 16132919
references: Rofo. 2002 Jun;174(6):725-30
references: 12063602
references: Radiology. 2001 Apr;219(1):114-22
references: 11274545
references: MAGMA. 2001 May;12(2-3):128-34
references: 11390268
references: AJR Am J Roentgenol. 2002 Oct;179(4):901-10
references: 12239035
references: Radiology. 2001 Mar;218(3):670-8
references: 11230638
references: Heart. 2003 Jun;89(6):633-9
references: 12748218
references: Radiology. 2002 Jan;222(1):120-6
references: 11756715
references: Radiology. 2003 Oct;229(1):217-23
references: 12944598
references: Radiology. 1998 May;207(2):529-38
references: 9577506
references: Eur Radiol. 2005 Aug;15(8):1598-606
references: 15815910
references: J Magn Reson Imaging. 1999 Nov;10(5):800-5
references: 10548791
references: J Cardiovasc Magn Reson. 1999;1(1):33-41
references: 11550339
references: Magn Reson Med. 2001 Nov;46(5):932-8
references: 11675645
references: Rofo. 2006 May;178(5):508-14
references: 16586314
references: J Magn Reson Imaging. 1999 Feb;9(2):220-7
references: 10077017
references: Invest Radiol. 2001 Aug;36(8):445-54
references: 11500594
references: Rofo. 2004 Nov;176(11):1589-98
references: 15497077
references: Magn Reson Med. 2003 Dec;50(6):1223-8
references: 14648570