Burning mouth syndrome (BMS): sialometric and sialochemical analysis and salivary protein profile.
OBJECTIVE
The aim of the present study was to analyse the characteristics of salivary production and its composition in individuals with burning mouth syndrome (BMS).


METHODS
Salivary flow rate, concentrations of potassium, iron, chloride, thiocyanate, magnesium, calcium, phosphorus, glucose, total protein and urea, as well as the expression profile of salivary proteins were analysed by SDS-PAGE.


RESULTS
The mean salivary flow rate among control patients was lower than that of BMS patients. Chloride, phosphorus and potassium levels were elevated in patients with BMS (p = 0.041, 0.001 and 0.034, respectively). Total salivary protein concentration was reduced in individuals with BMS (p = 0.223). Analysis of the expression of salivary proteins by Coomassie blue SDS-PAGE revealed a lower expression of low molecular weight proteins in individuals with BMS compared to healthy controls.


CONCLUSIONS
These results indicate that the identification and characterisation of low molecular weight salivary proteins in BMS may be important in understanding BMS pathogenesis, thus contributing to its diagnosis and treatment.
de Moura
Sérgio Adriane Bezerra
SA
Faculdade de Odontologia, Universidade Federal da Paraíba-João Pessoa, Brazil/Universidade Federal da Bahia, Salvador, Brazil. adsergio@yahoo.com.br
de Sousa
Jacira Maria Andrade
JM
Lima
Dilma Ferreira
DF
Negreiros
André Newton do Monte
AN
Silva
Fábio de Vasconcelos
Fde V
da Costa
Lino João
LJ
D000368:Aged; D000369:Aged, 80 and over; D002054:Burning Mouth Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000032:analysis*; D012472:Salivation / Q000502:physiology
D012471:Salivary Proteins and Peptides