[Anti-mullerian hormone and its role in the regulation of ovarian function. Review of the literature].
Anti-mullerian hormone, also called AMH, belongs to the large family of transforming growth factor P. Its role in the sexual differentiation of male fetus is now well known. Recently, AMH has been demonstrated to play an important role in the ovarian function. In fact, AMH seems to regulate the kinetics of follicular development, inhibiting the follicular recruitment and the follicular growth. Thus, this intra-gonadic cybernin could be a decisive determinant of the rapidity of follicular pool exhaustion. Today, some experimental data from the literature suggest that AMH could be a reliable marker of ovarian reserve. This review summarizes the present knowledge about AMH and its role in physiology but also in ovarian pathology.
Tsepelidis
S
S
Service de Gynécologie-Obstétrique, Hôpital Erasme, Bruxelles.
Demeestere
I
I
Delbaere
A
A
Gervy
C
C
Englert
Y
Y
D054304:Anti-Mullerian Hormone; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006023:Glycoproteins / Q000032:analysis / Q000502:physiology*; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D009095:Mullerian Ducts / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D010049:Ovarian Diseases / Q000175:diagnosis; D006080:Ovarian Follicle / Q000502:physiology; D010053:Ovary / Q000502:physiology*; D013735:Testicular Hormones / Q000032:analysis / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology
D015415:Biomarkers; D006023:Glycoproteins; D012739:Gonadal Steroid Hormones; D009479:Neuropeptides; D013735:Testicular Hormones; D016212:Transforming Growth Factor beta; C036580:cybernins; D054304:Anti-Mullerian Hormone