Serotonin transporter binding after recovery from eating disorders.
BACKGROUND
Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN).


OBJECTIVE
We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no binging or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW).


METHODS
Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP=DVregion of interest/DVcerebellum-1).


RESULTS
After correction for multiple comparisons, the four groups showed significant (p<0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions.


CONCLUSIONS
Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control.
Bailer
Ursula F
UF
Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.
Frank
Guido K
GK
Henry
Shannan E
SE
Price
Julie C
JC
Meltzer
Carolyn C
CC
Becker
Carl
C
Ziolko
Scott K
SK
Mathis
Chester A
CA
Wagner
Angela
A
Barbarich-Marsteller
Nicole C
NC
Putnam
Karen
K
Kaye
Walter H
WH
D000328:Adult; D000856:Anorexia Nervosa / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D052018:Bulimia Nervosa / Q000378:metabolism*; D002250:Carbon Radioisotopes; D005260:Female; D005838:Genotype; D006801:Humans; D007546:Isoquinolines; D007700:Kinetics; D008279:Magnetic Resonance Imaging; D009928:Organ Specificity; D011110:Polymorphism, Genetic; D049268:Positron-Emission Tomography; D011401:Promoter Regions, Genetic; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*
D002250:Carbon Radioisotopes; D007546:Isoquinolines; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; C058079:McN 5652
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