title: Airway stabilization with silicone stents for treating adult tracheobronchomalacia: a prospective observational study.
abstract: BACKGROUND
  It is postulated that in patients with severe tracheobronchomalacia (TBM), airway stabilization with stents may relieve symptoms.
  
  
  OBJECTIVE
  To evaluate the effect of silicone stents (tracheal, mainstem bronchus, or both) on symptoms, quality of life, lung function, and exercise capacity in these patients.
  
  
  METHODS
  A prospective observational study in which baseline measurements were compared to those obtained 10 to 14 days after stent placement.
  
  
  RESULTS
  Of 75 referred patients, 58 had severe disease and underwent therapeutic rigid bronchoscopy with stent placement. Mean age was 69 years (range, 39 to 91 years), 34 were men, 33 had COPD, and 13 had asthma. Almost all patients (n = 57) had dyspnea as a sole symptom or in combination with cough and recurrent infections; four patients required mechanical ventilation for respiratory failure. In 45 of 58 patients, there was reported symptomatic improvement; quality of life scores improved in 19 of 27 patients (p = 0.002); dyspnea scores improved in 22 of 24 patients (p = 0.001); functional status scores improved in 18 of 26 patients (p = 0.002); and mean exercise capacity improved from baseline, although not significantly. The 49 complications included mainly 21 partial stent obstructions, 14 infections, and 10 stent migrations. Most patients with concomitant COPD also improved on most measures.
  
  
  CONCLUSIONS
  In the short term, airway stabilization with silicone stents in patients with severe TBM can improve respiratory symptoms, quality of life, and functional status. Coexisting COPD is not an absolute contraindication to a stenting trial in this population. Stenting is associated with a high number of short-term and long-term but generally reversible complications.
authors: Chief, Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA. aernst@bidmc.harvard.edu
authors: Armin
authors: A
authors: Ernst
authors: Adnan
authors: A
authors: Majid
authors: David
authors: D
authors: Feller-Kopman
authors: Jorge
authors: J
authors: Guerrero
authors: Phillip
authors: P
authors: Boiselle
authors: Stephen H
authors: SH
authors: Loring
authors: Carl
authors: C
authors: O'Donnell
authors: Malcolm
authors: M
authors: Decamp
authors: Felix J F
authors: FJ
authors: Herth
authors: Sidhu
authors: S
authors: Gangadharan
authors: Simon
authors: S
authors: Ashiku
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000402:Airway Obstruction / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D001249:Asthma / Q000150:complications / Q000473:pathology / Q000628:therapy; D001980:Bronchi / Q000473:pathology / Q000601:surgery*; D001999:Bronchoscopy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019919:Prosthesis Implantation / Q000295:instrumentation; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000473:pathology / Q000628:therapy; D011788:Quality of Life; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012826:Silicone Elastomers; D015607:Stents; D014132:Trachea / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D012826:Silicone Elastomers