title: Endothelial dysfunction and C-reactive protein in relation with the severity of obstructive sleep apnea syndrome.
abstract: OBJECTIVE
  To investigate flow-mediated dilatation (FMD) and C-reactive protein (CRP) levels in patients with obstructive sleep apnea syndrome (OSAS) in relation with the severity of respiratory disturbances and hypoxemia.
  
  
  METHODS
  After subjects had completed nocturnal polysomnography, FMD was measured in the brachial artery, and blood samples were obtained to determine serum CRP levels.
  
  
  METHODS
  Sleep laboratory in Seoul National University Bundang Hospital.
  
  
  METHODS
  Ninety men: 22 normal controls, 28 subjects with mild to moderate OSAS, and 40 with severe OSAS.
  
  
  RESULTS
  FMD was found to be correlated with oxygen desaturation index (ODI), percentage of time below 90% O2 saturation, average O2 saturation, lowest O2 saturation, systolic blood pressure, apnea hypopnea index (AHI), and body mass index. In addition, CRP was correlated with body mass index, waist-to-hip ratio, neck circumference, diastolic pressure, average O2 saturation and percentage of time below 90% O2 saturation but not with AHI. Stepwise multiple regression showed that the ODI was a significant determinant of FMD (adjusted R2 = 10%, beta = -0.33, P < 0.01). In addition, body mass index (beta = 0.25, P < 0.05) and waist-to-hip ratio (beta = 0.21, P < 0.05) were found to be significantly correlated with CRP (adjusted R2 = 12%, P < 0.05), independently of other factors. There was no correlation between FMD and CRP.
  
  
  CONCLUSIONS
  As a marker of nocturnal hypoxemia, ODI rather than AHI might better explain the relationship between OSAS and FMD. Because body mass index and waist-to-hip ratio were identified as risk factors of high serum CRP in OSAS, obesity should be considered when predicting cardiovascular complications in OSAS.
authors: Department ofNeuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Seockhoon
authors: S
authors: Chung
authors: In-Young
authors: IY
authors: Yoon
authors: Yoon-Kyung
authors: YK
authors: Shin
authors: Chul Hee
authors: CH
authors: Lee
authors: Jeong-Whun
authors: JW
authors: Kim
authors: Taeseung
authors: T
authors: Lee
authors: Dong-Ju
authors: DJ
authors: Choi
authors: Hee Jeong
authors: HJ
authors: Ahn
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis; D014664:Vasodilation / Q000502:physiology; D049629:Waist-Hip Ratio
chemical_list: D002097:C-Reactive Protein; D010100:Oxygen
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