Skin testing correlates negatively with high-activity ACP1 *B/*C genotype.
BACKGROUND
Previous studies have shown a negative association between ACP1 *B/*C genotype and total IgE level. ACP1 (acid phosphatase locus 1) is a polymorphic phosphotyrosine phosphatase that interacts with IL4-RA and is involved in T cell receptor signaling.


METHODS
In the present paper, we have studied the relationship between *B/*C genotype which shows high ACP1 activity and skin testing in 300 adult subjects referred for allergic manifestations. ACP1 genotypes were determined by DNA analysis.


RESULTS
There is a significant negative correlation between the intensity of skin test reaction and *B/*C genotype (p = 0.01). The proportion of *B/*C genotype is lower in allergic subjects with intense skin reaction than in allergic subjects with moderate skin reaction and in healthy controls.


CONCLUSIONS
This new observation confirms by a different approach the relationship between ACP1 polymorphism and allergic manifestations, suggesting that high ACP1 activity protects against these manifestations.
Greco
E
E
Department of Internal Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy.
Bottini
N
N
Canu
G
G
Maccari
A M
AM
Saccucci
P
P
Gloria-Bottini
F
F
Fontana
L
L
D000328:Adult; D000485:Allergens / Q000276:immunology*; D005260:Female; D005838:Genotype; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D008297:Male; D011110:Polymorphism, Genetic; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012384:Rome / Q000453:epidemiology; D012882:Skin Tests
D000485:Allergens; D011518:Proto-Oncogene Proteins; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases