Synthesis of glycosyl-triazole linked 1,2,4-oxadiazoles.
The synthesis of four different types of oxadiazoles containing a terminal acetylenic group is described. Reaction of these oxadiazoles with various azidoglycosides via a copper-catalyzed [3+2] cycloaddition ('click chemistry') afforded the corresponding glycosyl-triazole linked 1,2,4-oxadiazoles in good yields.
dos Anjos
Janaína V
JV
Laboratoire de Synthèse Asymétrique, UMR 5246-ICBMS, CPE Lyon, Université de Lyon, 43 Boulevard du 11 Novembre 1918, F-69622 Villeurbanne, France.
Sinou
Denis
D
de Melo
Sebastiao J
SJ
Srivastava
Rajendra M
RM
D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry*
D010069:Oxadiazoles; D014230:Triazoles