title: Effects of normobaric hyperoxia on haemodynamic parameters of healthy full-term parturients.
abstract: Fifteen healthy, full-term women with singleton pregnancies were exposed to an increased F(I)o(2) of 0.4 and their haemodynamic responses measured with a non-invasive transthoracic bio-impedance monitor. There was a mean reduction in cardiac index from 3.18 to 3.03 l x min(-1) x m(-2) (4.7%, p = 0.004). The mean indexed systemic vascular resistance increased from 2049 to 2178 dynes x cm(-5) x m(-2) (5.7%, p = 0.005). There were no significant changes in stroke index, heart rate or mean arterial pressure. This study demonstrates that even a moderate increase in inspired oxygen fraction has significant effects on the cardiovascular system of the term parturient.
authors: Southern General Hospital, Department of Anaesthesia, 1345 Govan Road, Glasgow G51 4TF, UK. klitchfield@doctors.org.uk
authors: K N
authors: KN
authors: Litchfield
authors: J M
authors: JM
authors: Harten
authors: K J
authors: KJ
authors: Anderson
authors: J
authors: J
authors: Kinsella
authors: E M
authors: EM
authors: McGrady
mesh_terms: D000328:Adult; D002302:Cardiac Output / Q000502:physiology; D002307:Cardiography, Impedance; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy; D011247:Pregnancy / Q000502:physiology*; D011295:Prenatal Care / Q000379:methods*; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D010100:Oxygen