Anti-inflammatory neuropeptide receptors: new therapeutic targets for immune disorders?
The loss of immune tolerance results in the breakdown of immune homeostasis and the appearance of exacerbated inflammatory conditions. Some anti-inflammatory neuropeptides have recently emerged as endogenous factors participating in the maintenance of immune tolerance. The effects of these neuropeptides in self-tolerance primarily depend on the activation of cAMP-protein kinase A signaling and the regulation of various transduction pathways involved in the expression of many immune factors. Understanding of the structure-function relationship of anti-inflammatory neuropeptides and their receptors will facilitate the development of novel pharmacological agents for the treatment of immune disorders.
Gonzalez-Rey
Elena
E
Departamento de Bioquimica Medica y Biologia Molecular, Universidad de Sevilla, Sevilla 41009, Spain.
Delgado
Mario
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy* / Q000276:immunology; D007108:Immune Tolerance; D018836:Inflammation Mediators / Q000627:therapeutic use*; D009479:Neuropeptides / Q000627:therapeutic use*; D018013:Receptors, Neuropeptide / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators; D009479:Neuropeptides; D018013:Receptors, Neuropeptide