Site-specific oxidative stress induction.
In this issue of Chemistry & Biology, Kelly and colleagues describe the development of two novel ROS-generating compounds [1] that specifically localize in the nucleus or mitochondrion. Their application reveals that nuclei and mitochondria respond differently to oxidative stress, in terms of gene expression and survival pathway activation.
Terai
Takuya
T
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033 Tokyo, Japan.
Nagano
Tetsuo
T
D006367:HeLa Cells; D006801:Humans; D018384:Oxidative Stress; D012333:RNA, Messenger / Q000235:genetics; D017382:Reactive Oxygen Species / Q000378:metabolism*
D012333:RNA, Messenger; D017382:Reactive Oxygen Species