title: Apomorphine in the treatment of Parkinson's disease.
abstract: Motor fluctuations, refractory to conventional medical management, are one of the most troubling aspects of Parkinson's disease. Apomorphine is a dopaminergic agent that has been known to the medical community for more than a century, but has only recently been developed to treat such motor fluctuations. In this article, the authors review the historical background, structure, mechanism of action, pharmacologic properties, clinical trials, indications and side effects, as well as avenues of further research, of apomorphine.
authors: Duke University Medical Center, Durham, NC 27705, USA.
authors: Rukmini
authors: R
authors: Menon
authors: Mark
authors: M
authors: Stacy
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001058:Apomorphine / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000075202:Contraindications; D004333:Drug Administration Routes; D020820:Dyskinesias / Q000188:drug therapy; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic
chemical_list: D000978:Antiparkinson Agents; D001058:Apomorphine