Fas-1377 A/G polymorphism in lung cancer.
BACKGROUND
Reduced expression of Fas and/or increased expression of FasL is known to exist in some cancer types including lung cancer, so the Fas/FasL system may play a role in the course of cancer. Lack of cell surface Fas expression is one of the main routes of apoptotic resistance in tumor formation and progression. Functional mutations in the Fas gene that impair apoptotic signal transduction are associated with susceptibility to various types of cancer. In this study, we focused on lung cancer.


METHODS
The genotypic tendencies that may occur due to a specific point mutation (Fas-1377 G -->A) on promoter region for Fas were evaluated.


RESULTS
We did not find any relationship between Fas-1377 G-->A polymorphism and lung cancer. But there was a significantly higher number of AG patients who smoked than GG ones.


CONCLUSIONS
There was no relationship between Fas-1377 G-->A polymorphism and lung cancer, but it was statistically significant that smoking might increase the possibility of creating lung cancer in AG genotypes more than in other genotypes.
Gormus
Uzay
U
Istanbul University, Institute for Experimental Medical Research, Department of Molecular Medicine, Capa, Turkey.
Ergen
Arzu
A
Yaylim-Eraltan
Ilhan
I
Yilmaz
Hulya
H
Turna
Akif
A
Bozkurt
Nilüfer
N
Isbir
Turgay
T
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D000368:Aged; D017209:Apoptosis / Q000502:physiology; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D015398:Signal Transduction; D019014:fas Receptor / Q000235:genetics* / Q000378:metabolism
D019014:fas Receptor