Recent genetic selection in the ancestral admixture of Puerto Ricans.
Recent studies have used dense markers to examine the human genome in ancestrally homogeneous populations for hallmarks of selection. No genomewide studies have focused on recently admixed groups--populations that have experienced admixing among continentally divided ancestral populations within the past 200-500 years. New World admixed populations are unique in that they represent the sudden confluence of geographically diverged genomes with novel environmental challenges. Here, we present a novel approach for studying selection by examining the genomewide distribution of ancestry in the genetically admixed Puerto Ricans. We find strong statistical evidence of recent selection in three chromosomal regions, including the human leukocyte antigen region on chromosome 6p, chromosome 8q, and chromosome 11q. Two of these regions harbor genes for olfactory receptors. Interestingly, all three regions exhibit deficiencies in the European-ancestry proportion.
Tang
Hua
H
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Choudhry
Shweta
S
Mei
Rui
R
Morgan
Martin
M
Rodriguez-Cintron
William
W
Burchard
Esteban González
EG
Risch
Neil J
NJ
D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D015894:Genome, Human / Q000235:genetics; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012641:Selection, Genetic; D014481:United States / Q000208:ethnology
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