[The use of Emdogain in periodontal and osseous regeneration].
The goal of regenerative periodontal therapy is the reconstitution of the lost periodontal structures (i. e. the new formation of root cementum, periodontal ligament and alveolar bone). Results from basic research have pointed to the important role of an enamel matrix protein derivative (EMD) in periodontal wound healing. Histological results from experiments in animals and from human case reports have shown that treatment with EMD promotes periodontal regeneration. Moreover, clinical studies have indicated that treatment with EMD positively influences periodontal wound healing in humans. The goal of the current overview is to present the clinical indications for regenerative therapy with EMD based on the existing evidence.
Sculean
Anton
A
Department of Periodontology, Radboud University Medical Center, Nijmegen, The Netherlands. a.sculean@dent.umcn.nl
Rathe
Florian
F
Junker
Rüdiger
R
Becker
Jürgen
J
Schwarz
Frank
F
Arweiler
Nicole
N
D016301:Alveolar Bone Loss / Q000188:drug therapy* / Q000601:surgery; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D003746:Dental Enamel Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D017823:Furcation Defects / Q000188:drug therapy; D005889:Gingival Recession / Q000188:drug therapy; D006801:Humans; D010518:Periodontitis / Q000188:drug therapy* / Q000601:surgery; D010519:Periodontium / Q000187:drug effects / Q000502:physiology*; D012038:Regeneration / Q000187:drug effects*; D012391:Root Resorption / Q000517:prevention & control
D003746:Dental Enamel Proteins; C109069:enamel matrix proteins