title: Clinical evaluation of targeting accuracy of gamma knife radiosurgery in trigeminal neuralgia.
abstract: OBJECTIVE
  The efficiency of radiosurgery is related to its highly precise targeting. We assessed clinically the targeting accuracy of radiosurgical treatment with the Leksell Gamma Knife for trigeminal neuralgia. We also studied the applied radiation dose within the area of focal contrast enhancement on the trigeminal nerve root following radiosurgery.
  
  
  METHODS
  From an initial group of 78 patients with trigeminal neuralgia treated with gamma knife radiosurgery using a 90-Gy dose, we analyzed a subgroup of 65 patients for whom 6-month follow-up MRI showed focal contrast enhancement of the trigeminal nerve. Follow-up MRI was spatially coregistered to the radiosurgical planning MRI. Target accuracy was assessed from deviation of the coordinates of the intended target compared with the center of enhancement on postoperative MRI. Radiation dose delivered at the borders of contrast enhancement was evaluated.
  
  
  RESULTS
  The median deviation of the coordinates between the intended target and the center of contrast enhancement was 0.91 mm in Euclidean space. The radiation doses fitting within the borders of the contrast enhancement of the trigeminal nerve root ranged from 49 to 85 Gy (median value, 77 +/- 8.7 Gy).
  
  
  CONCLUSIONS
  The median deviation found in clinical assessment of gamma knife treatment for trigeminal neuralgia is low and compatible with its high rate of efficiency. Focal enhancement of the trigeminal nerve after radiosurgery occurred in 83% of our patients and was not associated with clinical outcome. Focal enhancement borders along the nerve root fit with a median dose of 77 +/- 8.7 Gy.
authors: Gamma Knife Center and Department of Neurosurgery, University Hospital Erasme, Université Libre de Bruxelles, Brussels, Belgium. nmassage@ulb.ac.be
authors: Nicolas
authors: N
authors: Massager
authors: Laurence
authors: L
authors: Abeloos
authors: Daniel
authors: D
authors: Devriendt
authors: Marc
authors: M
authors: Op de Beeck
authors: Marc
authors: M
authors: Levivier
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000295:instrumentation / Q000592:standards*; D011879:Radiotherapy Dosage; D014276:Trigeminal Nerve / Q000473:pathology / Q000601:surgery; D020433:Trigeminal Nerve Diseases / Q000209:etiology / Q000473:pathology; D014277:Trigeminal Neuralgia / Q000473:pathology / Q000601:surgery*