title: Targeted delivery of multifunctional magnetic nanoparticles.
abstract: Magnetic nanoparticles and their magnetofluorescent analogues have become important tools for in vivo imaging using magnetic resonance imaging and fluorescent optical methods. A number of monodisperse magnetic nanoparticle preparations have been developed over the last decade for angiogenesis imaging, cancer staging, tracking of immune cells (monocyte/macrophage, T cells) and for molecular and cellular targeting. Phage display and data mining have enabled the procurement of novel tissue- or receptor-specific peptides, while high-throughput screening of diversity-oriented synthesis libraries has identified small molecules that permit or prevent uptake by specific cell types. Next-generation magnetic nanoparticles are expected to be truly multifunctional, incorporating therapeutic functionalities and further enhancing an already diverse repertoire of capabilities.
authors: Center for Molecular Imaging Research, Harvard Medical School and Massachusetts General Hospital, 149 13th St, Rm 5406, Charlestown, MA 02129, USA. jason_mccarthy@hms.harvard.edu
authors: Jason R
authors: JR
authors: McCarthy
authors: Kimberly A
authors: KA
authors: Kelly
authors: Eric Y
authors: EY
authors: Sun
authors: Ralph
authors: R
authors: Weissleder
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D007089:Image Enhancement / Q000379:methods*; D008280:Magnetics / Q000627:therapeutic use*; D050997:Nanomedicine / Q000639:trends*; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D003287:Contrast Media