Feasibility and clinical applicability of polihexanide for treatment of second-degree burn wounds.
OBJECTIVE
Due to a partial rejection of mesh split-thickness skin grafts (mesh grafts) after application of povidone-iodine and silver nitrate and due to its better in vitro tolerance, polihexanide was investigated as an alternative and its applicability in the treatment of second-degree burn wounds.


METHODS
In 4 patients with poorly healing decubitus ulcers the mesh grafts were each divided into three areas which were pre-treated with either undiluted povidone-iodine solution, 1% silver nitrate solution or 0.04% polihexanide solution. After 7 days of application the wound areas were compared clinically and histologically. Thereafter 14 patients (average extent of burns 28% TBSA) were treated in the same way.


RESULTS
Clinically and histologically the mesh grafts treated with polihexanide showed by far the best re-epithelialization compared with the deep tissue necrosis and marked fibrin discharge observed for application of povidone-iodine and silver nitrate. The second-degree burn wounds treated with polihexanide epithelialized without any further débridement after an average of 10 days with remarkable freedom from pain. Compared with silver nitrate treatment, no fibrin film was observed on the wound.


CONCLUSIONS
Polihexanide proved clinically and histologically superior to povidone-iodine and silver nitrate. For the treatment of second-degree burns, which cannot primarily be covered by plastic surgery, polihexanide is suitable because in addition to its antiseptic efficacy it does not inhibit the re-epithelialization process.
Daeschlein
G
G
Institute of Hygiene and Environmental Medicine, Ernst Moritz Arndt University, Greifswald, Germany.
Assadian
O
O
Bruck
J C
JC
Meinl
C
C
Kramer
A
A
Koch
S
S
D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001645:Biguanides / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011206:Povidone-Iodine / Q000627:therapeutic use; D012835:Silver Nitrate / Q000627:therapeutic use; D016038:Skin Transplantation; D014945:Wound Healing / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D001645:Biguanides; C031233:polihexanide; D011206:Povidone-Iodine; D012835:Silver Nitrate