Use 'em and lose 'em-activity-induced removal of calcium channels from the plasma membrane.
Calcium influx via L-type (Cav1.2 and Cav1.3) calcium channels is tightly regulated to ensure optimal intracellular calcium levels. Although much is known about acute modulation of these channels by second messengers, the mechanisms that control their trafficking to and from the plasma membrane remain poorly understood. In this issue of Neuron, Green and colleagues demonstrate that the opening of L-type calcium channels results in negative feedback regulation due to their calcium-dependent internalization.
Varela
Diego
D
Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, T2N 4N1, Canada.
Zamponi
Gerald W
GW
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological
D020746:Calcium Channels, L-Type; D002118:Calcium