title: Muscle strength recovery in treated Guillain-Barré syndrome: a prospective study for the first 18 months after onset.
abstract: OBJECTIVE
  To assess the recovery in muscle strength and functional capacities in subjects with Guillain-Barré syndrome (GBS) for 18 months after onset.
  
  
  METHODS
  Six GBS patients were treated and transferred to our rehabilitation center within the first week of recovery.
  
  
  RESULTS
  Isometric and isokinetic strength increased significantly during the first 6 months (P < 0.01). Between 6 and 18 months, muscle strength increased less rapidly (P < 0.05). We showed a significant negative correlation between plateau period duration and knee extensors, elbow flexors muscles strength recovery (rho = -0.82; P = 0.05). At 6 months, manual muscle testing and functional independence motor total scores were close to normal levels. At 18 months, all patients satisfied the criteria for a full recovery. However, they felt difficulties after prolonged exercise.
  
  
  CONCLUSIONS
  Until 18 months of recovery, dynamometric measures still showed significant strength improvement. This underscores the need for a minimal 24 months of clinical follow-up with an individualized rehabilitation management program.
authors: Departments of Physical Medicine and Rehabilitation, CHU de Saint Etienne, Université Jean Monnet Saint Etienne, France.
authors: Lhassan
authors: L
authors: El Mhandi
authors: Paul
authors: P
authors: Calmels
authors: Jean Philippe
authors: JP
authors: Camdessanché
authors: Vincent
authors: V
authors: Gautheron
authors: Leonard
authors: L
authors: Féasson
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D005260:Female; D020275:Guillain-Barre Syndrome / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D018908:Muscle Weakness / Q000534:rehabilitation*; D011379:Prognosis; D011446:Prospective Studies; D020127:Recovery of Function; D013997:Time Factors