Second-trimester angiogenic factors as biomarkers for future-onset preeclampsia.
OBJECTIVE
The purpose of this study was to determine whether second-trimester soluble fms-like tyrosine kinase-1 and placenta growth factor (PlGF) are altered in patients who have preeclampsia develop compared with controls. Furthermore, soluble fms-like tyrosine kinase-1 and placenta growth factor levels in patients with chronic hypertension are described.


METHODS
With the use of a research database, 21 patients who had severe preeclampsia develop, 34 controls, and 9 patients with chronic hypertension were enrolled. Placenta growth factor and soluble fms-like tyrosine kinase-1 serum levels were determined by enzyme-linked immunosorbent assay. Appropriate statistical tests were used and results were reported as median (quartile 1-quartile 3) in picograms per milliliter.


RESULTS
Placenta growth factor was significantly lower in patients in the second trimester who later had severe preeclampsia develop but soluble fms-like tyrosine kinase-1 was unchanged compared with healthy pregnancies. In patients with chronic hypertension, placenta growth factor and soluble fms-like tyrosine kinase-1 levels were not different compared with controls.


CONCLUSIONS
Second-trimester placenta growth factor levels are altered in patients who had severe preeclampsia develop.
Unal
E Ramsey
ER
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC, USA.
Robinson
Christopher J
CJ
Johnson
Donna D
DD
Chang
Eugene Y
EY
D000328:Adult; D043925:Angiogenesis Inducing Agents / Q000097:blood*; D015415:Biomarkers; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011262:Pregnancy Trimester, Second; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
D043925:Angiogenesis Inducing Agents; D015415:Biomarkers; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1