title: Electroacupuncture alters the expression of genes associated with lipid metabolism and immune reaction in liver of hypercholesterolemia mice.
abstract: Acupuncture or electroacupuncture (EA) is effective in treating various metabolism disorders. Previously we found that EA at the acupoint, Fenglong (ST40), had the cholesterol-lowering effect and regulated genes expression in liver of hypercholesterolemia mice (M Li and YZ Zhang, Int J Mol Med 2007, 19: 617-629). To explain gene expression associated with EA, suppression subtractive hybridization (SSH), combined with targeted display (TD), was used and 26 up-regulated and 24 down-regulated genes with known functions were identified in hypercholesterolemia mice liver, some of which are involved in key reactions of lipid metabolism and immune reaction. Promoting lipid metabolism and suppressing inflammation via modulating mRNA expression may be the mechanism of EA inducing modulation of cholesterol concentrations.
authors: College of Life Science, Sichuan University, Chengdu, Sichuan, 610064, PR China.
authors: Yaoxia
authors: Y
authors: Kang
authors: Min
authors: M
authors: Li
authors: Wenqi
authors: W
authors: Yan
authors: Xingjie
authors: X
authors: Li
authors: Jinmei
authors: J
authors: Kang
authors: Yizheng
authors: Y
authors: Zhang
mesh_terms: D000818:Animals; D015536:Down-Regulation; D015671:Electroacupuncture / Q000379:methods*; D004587:Electrophoresis, Agar Gel; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006937:Hypercholesterolemia / Q000235:genetics* / Q000276:immunology*; D050356:Lipid Metabolism / Q000235:genetics*; D008099:Liver / Q000276:immunology* / Q000378:metabolism*; D051379:Mice; D009693:Nucleic Acid Hybridization; D054419:Receptors, Adiponectin / Q000235:genetics; D014158:Transcription, Genetic; D015854:Up-Regulation
chemical_list: D054419:Receptors, Adiponectin; C475421:adiponectin receptor 2, mouse