title: Effect of estrogen-progestin and estrogen on mammographic density.
abstract: OBJECTIVE
  To assess the different effects between non-treatment, estrogen and estrogen-progestin regimens on changes in mammographic density in postmenopausal women.
  
  
  METHODS
  A historical cohort of 105 postmenopausal women who attended the Menopause Clinic, Srinagarind Hospital, Khon Kaen, Thailand, and received 1 of 3 regimens: nontreatment, estrogen or estrogen-progestin (35 in each group). Mammographic examinations were done before and after a 12-24-month period of hormone therapy. Breast density (mammographic density, recorded in the medical records) between the 2 examinations in each group were compared.
  
  
  RESULTS
  An increase in mammographic density occurred among women receiving hormone therapy: 40% (14 of 35) in the estrogen-progestin group and 20% (7 of 35) in the estrogen-only group, but no variation in density was observed in the nontreatment group. The increase in mammographic density occurring in women on hormone therapy, as compared to the nontreatment group, was statistically significant (estrogen-progestin, 95% CI 20.91-59.09; estrogen, 95% CI 3.89-36.11). When the different treatment types were compared, the estrogen-progestin group tended to have a higher prevalence of mammographic density change than the estrogen-only group, but the difference was not statistically significant (95% CI -3.81-43.81).
  
  
  CONCLUSIONS
  Hormone therapy was associated with increased mammographic density. Apparently the estrogen-progestin regimen affects breast density more than estrogen-only does.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. ksrina@kku.ac.th
authors: Srinaree
authors: S
authors: Kaewrudee
authors: Sanitra
authors: S
authors: Anuwutnavin
authors: Jaturat
authors: J
authors: Kanpittaya
authors: Sugree
authors: S
authors: Soontrapa
authors: Chuanchum
authors: C
authors: Sakondhavat
mesh_terms: D001940:Breast / Q000187:drug effects*; D015331:Cohort Studies; D004338:Drug Combinations; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008327:Mammography / Q000706:statistics & numerical data*; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects*; D011372:Progestins / Q000494:pharmacology*; D013785:Thailand
chemical_list: D004338:Drug Combinations; D004967:Estrogens; D011372:Progestins