title: Association of XPD polymorphisms with prostate cancer in Taiwanese patients.
abstract: BACKGROUND
  The DNA repair gene XPD, an important caretaker of the overall genome stability, is thought to play a major role in the development of human malignancy. Polymorphic variants of XPD, at codon 312, 751, and other sites, have been associated with cancer susceptibility, but few studies have investigated their effect on prostate cancer risk.
  
  
  METHODS
  In this hospital-based case-control study, the association of XPD codon 312, 751 and promoter-114 polymorphisms with prostate cancer risk in a Taiwanese population were investigated. In total, 123 patients with prostate cancer and 479 healthy controls recruited from the China Medical Hospital in Central Taiwan were genotyped.
  
  
  RESULTS
  We found a significant difference in the frequency of the XPD codon 312 genotype, but not the XPD codon 751 or promoter-114 genotypes, between the prostate cancer and control groups. Those who had GIA or A/A at XPD codon 312 showed a 1.81-fold (95% confidence interval=1.21-2.69) increased risk of prostate cancer compared to those with GIG. As for XPD codon 312 or promoter-114, there was no difference in distribution between the prostate cancer and control groups.
  
  
  CONCLUSIONS
  Our findings suggest that the heterozygous and homozygous A allele of the XPD codon 312 may be associated with the development of prostate cancer and may be a useful marker for primary prevention and anticancer intervention.
authors: Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC.
authors: Da-Tian
authors: DT
authors: Bau
authors: Hsi-Chin
authors: HC
authors: Wu
authors: Chang-Fang
authors: CF
authors: Chiu
authors: Cheng-Chieh
authors: CC
authors: Lin
authors: Chin-Moo
authors: CM
authors: Hsu
authors: Cheng-Li
authors: CL
authors: Wang
authors: Rou-Fen
authors: RF
authors: Wang
authors: Fuu-Jen
authors: FJ
authors: Tsai
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003062:Codon; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D003062:Codon; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human