title: Enantioselective addition of terminal alkynes to aldehydes catalyzed by a Cu(I)-TRAP complex.
abstract: The addition of terminal alkynes to aromatic aldehydes was carried out under mild conditions in the presence of a Cu-phosphine complex, which was prepared in situ from Cu(O-t-Bu) and TRAP chiral bisphosphine, to yield enantiomerically enriched propargyl alcohols with moderate enantioselectivities. Furthermore, according to stoichiometric reactions, the reaction presumably involves the addition of a TRAP-coordinated Cu(I) acetylide to an aldehyde.
authors: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
authors: Yohsuke
authors: Y
authors: Asano
authors: Kenji
authors: K
authors: Hara
authors: Hajime
authors: H
authors: Ito
authors: Masaya
authors: M
authors: Sawamura