title: PPARs and Adipose Cell Plasticity.
abstract: Due to the importance of fat tissues in both energy balance and in the associated disorders arising when such balance is not maintained, adipocyte differentiation has been extensively investigated in order to control and inhibit the enlargement of white adipose tissue. The ability of a cell to undergo adipocyte differentiation is one particular feature of all mesenchymal cells. Up until now, the peroxysome proliferator-activated receptor (PPAR) subtypes appear to be the keys and essential players capable of inducing and controlling adipocyte differentiation. In addition, it is now accepted that adipose cells present a broad plasticity that allows them to differentiate towards various mesodermal phenotypes. The role of PPARs in such plasticity is reviewed here, although no definite conclusion can yet be drawn. Many questions thus remain open concerning the definition of preadipocytes and the relative importance of PPARs in comparison to other master factors involved in the other mesodermal phenotypes.
authors: IFR 31, Institut Louis Bugnard, CNRS/UPS UMR 5241, 31432 Toulouse Cedex 4, France.
authors: Louis
authors: L
authors: Casteilla
authors: Béatrice
authors: B
authors: Cousin
authors: Mamen
authors: M
authors: Carmona
references: FEBS Lett. 2006 Jul 24;580(17):4121-5
references: 16828750
references: Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):9-15
references: 15936182
references: Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):31-4
references: 15936931
references: Mol Cell Endocrinol. 1999 Aug 20;154(1-2):101-9
references: 10509805
references: Mol Biol Cell. 2002 Dec;13(12):4279-95
references: 12475952
references: Ann Plast Surg. 1986 Mar;16(3):179-94
references: 3273033
references: Physiol Rev. 1984 Jan;64(1):1-64
references: 6320232
references: J Cell Biochem. 2006 May 15;98(2):251-66
references: 16479589
references: Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15675-80
references: 17030820
references: J Biol Chem. 2003 Aug 29;278(35):33370-6
references: 12807871
references: Curr Opin Pharmacol. 2004 Jun;4(3):290-4
references: 15140422
references: Int J Obes Relat Metab Disord. 2000 Nov;24 Suppl 4:S8-10
references: 11126248
references: Int J Obes Relat Metab Disord. 2000 Jun;24 Suppl 2:S1-3
references: 10997598
references: Prostaglandins Other Lipid Mediat. 2006 Sep;80(3-4):165-74
references: 16939881
references: J Biol Chem. 2006 May 5;281(18):12673-81
references: 16524877
references: Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4112-7
references: 15024128
references: Plast Reconstr Surg. 2006 Sep;118(3 Suppl):121S-128S
references: 16936551
references: Endocr Relat Cancer. 2006 Jun;13(2):401-13
references: 16728570
references: Dev Cell. 2002 Mar;2(3):331-41
references: 11879638
references: Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10826-31
references: 10995476
references: J Clin Endocrinol Metab. 1996 Jan;81(1):368-75
references: 8550779
references: Nutrition. 2004 Jan;20(1):115-20
references: 14698025
references: Biochem Biophys Res Commun. 2003 Sep 26;309(3):502-5
references: 12963017
references: Diabetes Metab. 2006 Nov;32(5 Pt 1):393-401
references: 17110894
references: J Clin Invest. 2003 Dec;112(12):1821-30
references: 14679177
references: Biochem Biophys Res Commun. 2005 Feb 18;327(3):811-9
references: 15649418
references: J Clin Invest. 2006 Dec;116(12):3220-8
references: 17143331
references: Nat Med. 2000 Sep;6(9):985-90
references: 10973317
references: J Cell Sci. 1992 Dec;103 ( Pt 4):931-42
references: 1362571
references: Cell. 1998 Mar 20;92(6):829-39
references: 9529258
references: New Biol. 1990 Apr;2(4):304-12
references: 2288904
references: Science. 2000 Oct 6;290(5489):134-8
references: 11021798
references: Endocr Rev. 2000 Dec;21(6):697-738
references: 11133069
references: Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):237-41
references: 8990192
references: Exp Cell Res. 2006 Apr 1;312(6):727-36
references: 16386732
references: Int J Obes (Lond). 2005 Jul;29(7):864-71
references: 15917863
references: Endocr Rev. 2006 Dec;27(7):728-35
references: 17018837
references: Mol Cell Biol. 2004 Apr;24(7):2820-30
references: 15024071
references: FASEB J. 1999 Feb;13(2):305-12
references: 9973318
references: Dev Cell. 2002 Jul;3(1):39-49
references: 12110166
references: Exp Cell Res. 2003 Aug 1;288(1):168-76
references: 12878168
references: Eur J Biochem. 1991 May 23;198(1):195-9
references: 2040279
references: J Clin Invest. 2004 Dec;114(11):1564-76
references: 15578089
references: Biochem Biophys Res Commun. 2001 Mar 9;281(4):902-6
references: 11237745
references: Cytotherapy. 2003;5(5):362-9
references: 14578098
references: FASEB J. 1990 Aug;4(11):2890-8
references: 2199286
references: Nat Med. 2004 Apr;10(4):355-61
references: 15057233
references: Diabetes Metab. 2005 Feb;31(1):23-7
references: 15803109
references: Biochem J. 2001 Jun 1;356(Pt 2):659-64
references: 11368797
references: FASEB J. 2004 Sep;18(12):1477-9
references: 15247146
references: Endocrinology. 2005 Aug;146(8):3547-57
references: 15878958
references: Nature. 1998 Jan 1;391(6662):79-82
references: 9422508
references: Science. 2000 Aug 11;289(5481):950-3
references: 10937998
references: Int J Biochem. 1991;23(9):791-801
references: 1773883
references: J Reprod Dev. 2007 Jun;53(3):563-72
references: 17272924
references: Science. 1999 Apr 2;284(5411):143-7
references: 10102814
references: Plast Reconstr Surg. 2007 Jan;119(1):71-83; discussion 84-5
references: 17255658
references: J Biol Chem. 2004 Oct 22;279(43):45020-7
references: 15308623
references: Mol Endocrinol. 2007 May;21(5):1120-31
references: 17312274
references: Diabetes. 1998 Apr;47(4):507-14
references: 9568680
references: Tissue Eng. 2006 Jan;12(1):21-31
references: 16499439
references: J Cell Sci. 1997 Jun;110 ( Pt 11):1279-85
references: 9202388
references: Nat Cell Biol. 2003 Mar;5(3):224-30
references: 12598905
references: J Biol Chem. 2003 Mar 14;278(11):9850-5
references: 12519759
references: Science. 2005 Aug 12;309(5737):1074-8
references: 16099986
references: FASEB J. 2005 Dec;19(14):2029-31
references: 16188961
references: J Cell Physiol. 2006 Jun;207(3):722-8
references: 16482529
references: Nat Med. 2001 Jan;7(1):41-7
references: 11135614
references: Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E617-26
references: 15941786
references: Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9856-60
references: 7568232
references: J Exp Med. 2005 May 2;201(9):1397-405
references: 15867092
references: Annu Rev Nutr. 1992;12:207-33
references: 1503804
references: Genes Dev. 1997 Aug 1;11(15):1987-98
references: 9271121
references: J Lipid Res. 2002 Feb;43(2):177-86
references: 11861659
references: Mol Cell Biol. 2005 Nov;25(21):9383-91
references: 16227589