Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea.
Selective serotonin reuptake inhibitor (SSRI)-induced nausea can be severe enough to lead to early treatment discontinuation. However, it is currently not possible to predict the occurrence of nausea before the initiation of SSRI treatment. In this study, we investigated the effect of genetic polymorphisms in the 5-hydroxytryptamine type 2A, 3A, and 3B (5-HT3B) receptors, 5-HT transporter, and CYP2D6 genes on the incidence of paroxetine-induced nausea. A consecutive series of 72 Japanese patients with depressive or anxiety disorders were treated with paroxetine. Paroxetine-induced nausea was assessed by a pharmacist and was observed in 29.2% of the patients. A significant (nominal p=0.00286) association was found between the incidence of nausea and the -100_-102AAG insertion/deletion polymorphism of the 5-HT3B receptor gene. No significant associations were observed between the other genetic polymorphisms and the incidence of nausea. The -100_-102AAG deletion variant of the 5-HT3B receptor gene may affect paroxetine-induced nausea.
Tanaka
Misuzu
M
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Kobayashi
Daisuke
D
Murakami
Yuko
Y
Ozaki
Norio
N
Suzuki
Tatsuyo
T
Iwata
Nakao
N
Haraguchi
Koichi
K
Ieiri
Ichiro
I
Kinukawa
Naoko
N
Hosoi
Masako
M
Ohtani
Hisakazu
H
Sawada
Yasufumi
Y
Mine
Kazunori
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000097:blood; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000235:genetics; D003866:Depressive Disorder / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D007564:Japan; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics; D017374:Paroxetine / Q000009:adverse effects* / Q000097:blood; D011110:Polymorphism, Genetic; D044406:Receptors, Serotonin, 5-HT3 / Q000235:genetics*; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000097:blood; D012720:Severity of Illness Index
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine; D044406:Receptors, Serotonin, 5-HT3; D017367:Selective Serotonin Reuptake Inhibitors