Pordamacrines A and B, alkaloids from Daphniphyllum macropodum.
The new Daphniphyllum alkaloids, pordamacrines A (1) and B (2), have been isolated from the leaves of Daphniphyllum macropodum, and their structures were elucidated on the basis of interpretation of spectroscopic data and by the single-crystal X-ray diffraction analysis of 2. Pordamacrines A (1) and B (2) exhibited moderate vasorelaxant effects on the rat aorta.
Matsuno
Yosuke
Y
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo, Japan.
Okamoto
Mariko
M
Hirasawa
Yusuke
Y
Kawahara
Nobuo
N
Goda
Yukihiro
Y
Shiro
Motoo
M
Morita
Hiroshi
H
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D018360:Crystallography, X-Ray; D007564:Japan; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000470:Alkaloids; D014665:Vasodilator Agents; C524245:pordamacrine A; C524246:pordamacrine B