Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course.
OBJECTIVE
Recent studies highlight the role of chemokines for the attraction of inflammatory cells in liver injury and fibrogenesis. The CC chemokine ligand 11, eotaxin (CCL11), is up-regulated in senescent human hepatic stellate cells and crucial in animal models of T-cell mediated hepatitis. The aim of this study was to analyze the role of eotaxin in chronic liver disease.


METHODS
Plasma eotaxin levels of 111 patients with chronic liver disease were correlated with clinical presentation, laboratory parameters, liver histology and clinical course in a 6-year follow-up.


RESULTS
Eotaxin concentrations were significantly up-regulated in patients with liver cirrhosis and increased according to Child-Pugh and model of end-stage liver disease (MELD) score. Eotaxin correlated with the hepatic biosynthetic capacity and other inflammatory cytokines. High eotaxin was associated with hepatic necroinflammation and fibrosis in liver histology. In patients with typical clinical complications of cirrhosis, eotaxin was found to be increased. High eotaxin indicated an unfavorable prognosis in 6-year follow-up.


CONCLUSIONS
High eotaxin expression may be involved in the pathogenesis of chronic liver diseases. Plasma eotaxin levels correlate with the degree of liver cirrhosis and could serve as an additional biomarker indicating histological hepatic necroinflammation and fibrosis as well as an adverse clinical course.
Tacke
Frank
F
Medical Clinic III, University Hospital Aachen, Aachen, Germany. frank.tacke@gmx.net
Trautwein
Christian
C
Yagmur
Eray
E
Hellerbrand
Claus
C
Wiest
Reiner
R
Brenner
David A
DA
Schnabl
Bernd
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications / Q000401:mortality / Q000473:pathology*; D008107:Liver Diseases / Q000097:blood / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D015854:Up-Regulation
C515456:CCL11 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC