title: Apparent diffusion coefficient of pituitary macroadenoma evaluated with line-scan diffusion-weighted imaging.
abstract: OBJECTIVE
  The goal of this study was to evaluate the consistency of pituitary macroadenoma using apparent diffusion coefficient (ADC) with line-scan diffusion-weighted imaging (LSDWI).
  
  
  METHODS
  Patients with pituitary macroadenoma (n=19) were studied prospectively. The LSDWI was performed using a maximum b factor of 1000 s/mm2. The consistency of macroadenoma was rated as soft, intermediate or hard at transsphenoidal surgery. The ADC values of tumors were compared with the tumor-consistency ratings.
  
  
  RESULTS
  A soft consistency was found at surgery in 13 patients (mean ADC: 0.84+/-0.1x10(-3) mm2/s); an intermediate consistency was observed in six patients (mean ADC: 0.81+/-0.16x10(-3) mm2/s). No tumors of hard consistency were found. There was no significant difference in ADC values between tumors of soft consistency compared with tumors of intermediate consistency (P=0.37).
  
  
  CONCLUSIONS
  A relationship between tumor consistency and the ADCs of soft and intermediate macroadenomas was not shown in this study using LSDWI.
authors: Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
authors: C
authors: C
authors: Suzuki
authors: M
authors: M
authors: Maeda
authors: K
authors: K
authors: Hori
authors: Y
authors: Y
authors: Kozuka
authors: H
authors: H
authors: Sakuma
authors: W
authors: W
authors: Taki
authors: K
authors: K
authors: Takeda
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D016880:Anisotropy; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D011446:Prospective Studies