title: In vivo corneal high-speed, ultra high-resolution optical coherence tomography.
abstract: OBJECTIVE
  To introduce new corneal high-speed, ultra-high-resolution optical coherence tomography (hsUHR-OCT) technology that improves the evaluation of complicated and uncomplicated cataract, corneal, and refractive surgical procedures.
  
  
  METHODS
  This case series included a control subject and 9 eyes of 8 patients who had undergone phacoemulsification, Descemet membrane stripping endokeratoplasty, corneal implantation for keratoconus, and complicated and uncomplicated laser in situ keratomileusis. These eyes underwent imaging using a prototype ophthalmic hsUHR-OCT system. All the scans were compared with conventional slitlamp biomicroscopy.
  
  
  RESULTS
  Cross-sectional hsUHR-OCT imaging allowed in vivo differentiation of corneal layers and existing pathologic abnormalities at ultrahigh axial image resolution. These images illustrate the various incisional and refractive interfaces created with corneal procedures.
  
  
  CONCLUSIONS
  The magnified view of the cornea using hsUHR-OCT is helpful in conceptualizing and understanding basic and complicated clinical pathologic features; hsUHR-OCT has the potential to become a powerful, noninvasive clinical corneal imaging modality that can enhance surgical management.
  
  
  BACKGROUND
  clinicaltrials.gov Identifier: NCT00343473.
authors: UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop St, Suite 827, Pittsburgh, PA 15213, USA.
authors: Viki
authors: V
authors: Christopoulos
authors: Larry
authors: L
authors: Kagemann
authors: Gadi
authors: G
authors: Wollstein
authors: Hiroshi
authors: H
authors: Ishikawa
authors: Michelle L
authors: ML
authors: Gabriele
authors: Maciej
authors: M
authors: Wojtkowski
authors: Vivek
authors: V
authors: Srinivasan
authors: James G
authors: JG
authors: Fujimoto
authors: Jay S
authors: JS
authors: Duker
authors: Deepinder K
authors: DK
authors: Dhaliwal
authors: Joel S
authors: JS
authors: Schuman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000473:pathology*; D003315:Cornea / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000473:pathology* / Q000601:surgery; D020731:Keratomileusis, Laser In Situ / Q000379:methods; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000473:pathology* / Q000601:surgery; D018918:Phacoemulsification / Q000379:methods; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*
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