title: Effects of acute exposure to a 1439 MHz electromagnetic field on the microcirculatory parameters in rat brain.
abstract: THE AIM of this study was to determine the potential of radio-frequency electromagnetic fields (RF-EMF) to affect cerebral microcirculation, including blood-brain barrier function, in rat brain.
  
  
  METHODS
  The head of the rat was exposed for 10 min to 1439 MHz RF-EMF having three intensity doses: 0.6, 2.4, 4.8 W/kg of brain averaged specific absorption rate (BASAR). Four microcirculatory parameters: blood-brain barrier permeability, leukocyte behavior, plasma velocity, and vessel diameter were measured before and after RF-EMF exposure using a closed cranial window method.
  
  
  RESULTS
  No extravasation of intravenously injected dyes from pial venules was found at any BASAR level. No significant changes in the number of endothelial-adhering leukocytes after exposure were found. The hemodynamics indicated that the plasma velocities and vessel diameters remained constant within the physiological range throughout each exposure.
  
  
  CONCLUSIONS
  These findings suggest that there were no effects on the cerebral microcirculation under the given RF-EMF exposure conditions.
authors: Department of Environmental Health, National Institute of Public Health, Wako-shi, Saitama, Japan. msd@niph.go.jp
authors: Hiroshi
authors: H
authors: Masuda
authors: Akira
authors: A
authors: Ushiyama
authors: Shogo
authors: S
authors: Hirota
authors: Kanako
authors: K
authors: Wake
authors: Soichi
authors: S
authors: Watanabe
authors: Yukio
authors: Y
authors: Yamanaka
authors: Masao
authors: M
authors: Taki
authors: Chiyoji
authors: C
authors: Ohkubo
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000528:radiation effects; D001812:Blood-Brain Barrier / Q000528:radiation effects*; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D005456:Fluorescent Dyes / Q000493:pharmacokinetics; D007962:Leukocytes / Q000528:radiation effects; D008297:Male; D008833:Microcirculation / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013696:Temperature
chemical_list: D005456:Fluorescent Dyes