title: An open study of repetitive transcranial magnetic stimulation in treatment-resistant depression with Parkinson's disease.
abstract: OBJECTIVE
  Major depression is a common concomitant of chronic central nervous system disorders, notably Parkinson's disease (PD). Repetitive transcranial magnetic stimulation (rTMS) has been investigated as a potential treatment for depression in PD and for the movement disorder of PD, but comprehensive testing in multiple areas of performance has seldom been carried out within a single study. We studied the effect of left dorsolateral prefrontal rTMS on several different functional domains.
  
  
  METHODS
  Fourteen PD patients with treatment-resistant depression entered an open, 10-day inpatient study of 10-Hz rTMS, undergoing extensive psychiatric, neuropsychological, and motor testing from baseline to 6 weeks after treatment. Motor testing included a defined "off" state.
  
  
  RESULTS
  rTMS was well tolerated. Highly significant improvement in depression scores was seen 3 days and 3-6 weeks after treatment. Improvement was also found in anxiety, movement scores (especially in the off state), and some neuropsychological measures. We found no evidence of increased risk from rTMS in this population.
  
  
  CONCLUSIONS
  Further controlled trials of rTMS in PD appear worthwhile, and should include a defined "off" state.
  
  
  CONCLUSIONS
  TMS may be beneficial for depressed PD patients in multiple functional domains.
authors: Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. chipstein@earthlink.net
authors: Charles M
authors: CM
authors: Epstein
authors: Marian L
authors: ML
authors: Evatt
authors: Agnes
authors: A
authors: Funk
authors: Lhys
authors: L
authors: Girard-Siqueira
authors: Nichole
authors: N
authors: Lupei
authors: Larisa
authors: L
authors: Slaughter
authors: Saima
authors: S
authors: Athar
authors: Joanne
authors: J
authors: Green
authors: William
authors: W
authors: McDonald
authors: Mahlon R
authors: MR
authors: DeLong
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D003866:Depressive Disorder / Q000209:etiology* / Q000523:psychology / Q000628:therapy*; D004351:Drug Resistance; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D050781:Transcranial Magnetic Stimulation / Q000009:adverse effects
chemical_list: D000928:Antidepressive Agents
references: J Psychiatr Res. 1975 Nov;12(3):189-98
references: 1202204
references: J Neurol. 1998 May;245 Suppl 1:S10-4
references: 9617716
references: Neurology. 2000 Feb 8;54(3):710-4
references: 10680808
references: Am J Geriatr Psychiatry. 1998 Summer;6(3):263-9
references: 9659959
references: J Neurol Neurosurg Psychiatry. 2004 Aug;75(8):1171-4
references: 15258224
references: Br J Soc Clin Psychol. 1967 Dec;6(4):278-96
references: 6080235
references: Am J Psychiatry. 1997 Dec;154(12):1752-6
references: 9396958
references: Biol Psychiatry. 2000 Feb 15;47(4):332-7
references: 10686268
references: Encephale. 1993 Sep-Oct;19(5):573-8
references: 8306926
references: Br J Med Psychol. 1959;32(1):50-5
references: 13638508
references: J ECT. 1998 Mar;14(1):25-7
references: 9661090
references: J Neuropsychiatry Clin Neurosci. 1998 Winter;10(1):20-5
references: 9547462
references: Neuroreport. 1995 Oct 2;6(14):1853-6
references: 8547583
references: Mov Disord. 2005 Sep;20(9):1178-84
references: 15895421
references: Arch Neurol. 1999 Jan;56(1):33-9
references: 9923759
references: Electroencephalogr Clin Neurophysiol. 1994 Aug;91(2):79-92
references: 7519144
references: Brain Res Bull. 2004 Sep 30;64(3):259-63
references: 15464863
references: Arch Neurol. 1996 Feb;53(2):175-9
references: 8639068
references: J Clin Neurophysiol. 2002 Aug;19(4):376-81
references: 12436092
references: Clin Neurophysiol. 2004 Nov;115(11):2530-41
references: 15465443
references: J Neurol Neurosurg Psychiatry. 1995 May;58(5):641-2
references: 7745424
references: Mov Disord. 2003 Apr;18(4):382-8
references: 12671943
references: Mov Disord. 2006 Mar;21(3):325-31
references: 16211618
references: Biol Psychiatry. 2006 Jan 15;59(2):187-94
references: 16139808
references: J Neural Transm. 1980;49(1-2):133-5
references: 7441236
references: Neuropharmacology. 2002 Jul;43(1):101-9
references: 12213264
references: Mov Disord. 2003 Mar;18(3):267-274
references: 12621629
references: Psychopharmacol Bull. 2001 Autumn;35(4):149-69
references: 12397863
references: Clin Neurophysiol. 2007 Jan;118(1):131-9
references: 17097342
references: Science. 2001 Aug 10;293(5532):1164-6
references: 11498597
references: J Neurol Sci. 2003 May 15;209(1-2):41-6
references: 12686400
references: Ann Clin Psychiatry. 2005 Jul-Sep;17(3):153-9
references: 16433057
references: Cereb Cortex. 2004 Apr;14(4):404-9
references: 15028644
references: Biol Psychiatry. 2003 Feb 15;53(4):324-31
references: 12586451