Cytokine gene polymorphisms in hepatitis C virus-related oral lichen planus.
Cytokine polymorphisms may influence both the risk of developing oral lichen planus (OLP) and the outcome of hepatitis C virus (HCV)-infected patients and OLP has been frequently associated with HCV infection. The aim of the present study was to analyse whether cytokine polymorphisms may influence the susceptibility to HCV-related OLP. Thirty-five patients with OLP and chronic HCV infection (OLP-HCV+ve) took part in the study. As controls, 44 patients with OLP but without HCV (OLP-HCV-ve) infection and 140 healthy donors were studied. Thirteen cytokine genes with 22 single nucleotide polymorphisms (SNP) were studied. IFN-gamma UTR 5644 genotype frequencies showed an increase in number of A/T heterozygote in OLP-HCV+ve patients compared with OLP-HCV-ve that approached the statistical significance [P = 0.03, P-corrected (PC) = 0.66]. Contrarily, in OLP-HCV+ve patients, the frequency of genotype -308 G/A of the TNF-alpha was decreased, whereas the genotype -308 G/G was increased compared with OLP-HCV-ve (P = 0.0005, PC = 0.011 and P = 0.0016, PC = 0.0352, respectively). OLP patients with and without HCV infection showed a different genetic cytokine background suggesting distinct pathogenetic mechanisms.
Carrozzo
Marco
M
Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, University of Turin, Turin, Italy. marco-carrozzo@ncl.ac.uk
Dametto
Ennia
E
Fasano
Maria Edvige
ME
Arduino
Paolo
P
Bertolusso
Giorgio
G
Uboldi de Capei
Federica
F
Rendine
Sabina
S
Amoroso
Antonio
A
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications*; D006579:Heterozygote; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D007558:Italy; D017676:Lichen Planus, Oral / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma