Laser diffractometry and cascade impaction for nebulizer product characterization.
The techniques of laser diffractometry and multi-stage cascade impaction are widely used in the in vitro characterization of liquid droplet aerosols generated from nebulizing systems. This position paper is a concise summary of key aspects relating to both techniques and is intended to inform the development of the proposed general chapter 2.9.44 "Preparations for Nebulization" for the European Pharmacopeia, as well as assist in the development of a proposed International Standard (ISO 27427) for nebulizing systems.
Mitchell
J P
JP
Trudell Medical International, 725 Third Street, London, Canada N5V 5G4. jmitchell@trudellmed.com
Tservistas
M
M
D000336:Aerosols / Q000737:chemistry* / Q000592:standards; D005060:Europe; D017408:Guidelines as Topic; D007834:Lasers; D009330:Nebulizers and Vaporizers; D010316:Particle Size; D010602:Pharmacopoeias as Topic; D011786:Quality Control; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000592:standards
D000336:Aerosols