title: Microstructural analysis of deformation-induced hypoxic damage in skeletal muscle.
abstract: Deep pressure ulcers are caused by sustained mechanical loading and involve skeletal muscle tissue injury. The exact underlying mechanisms are unclear, and the prevalence is high. Our hypothesis is that the aetiology is dominated by cellular deformation (Bouten et al. in Ann Biomed Eng 29:153-163, 2001; Breuls et al. in Ann Biomed Eng 31:1357-1364, 2003; Stekelenburg et al. in J App Physiol 100(6):1946-1954, 2006) and deformation-induced ischaemia. The experimental observation that mechanical compression induced a pattern of interspersed healthy and dead cells in skeletal muscle (Stekelenburg et al. in J App Physiol 100(6):1946-1954, 2006) strongly suggests to take into account the muscle microstructure in studying damage development. The present paper describes a computational model for deformation-induced hypoxic damage in skeletal muscle tissue. Dead cells stop consuming oxygen and are assumed to decrease in stiffness due to loss of structure. The questions addressed are if these two consequences of cell death influence the development of cell injury in the remaining cells. The results show that weakening of dead cells indeed affects the damage accumulation in other cells. Further, the fact that cells stop consuming oxygen after they have died, delays cell death of other cells.
authors: Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands. k.k.ceelen@tue.nl
authors: K K
authors: KK
authors: Ceelen
authors: C W J
authors: CW
authors: Oomens
authors: F P T
authors: FP
authors: Baaijens
mesh_terms: D015687:Cell Hypoxia; D019245:Compressive Strength; D003198:Computer Simulation; D004548:Elasticity; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000473:pathology* / Q000503:physiopathology* / Q000648:ultrastructure; D010100:Oxygen / Q000378:metabolism*; D010812:Physical Stimulation / Q000009:adverse effects*; D003668:Pressure Ulcer / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D013314:Stress, Mechanical
chemical_list: D010100:Oxygen
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