title: [Primary vitrectomy with intraocular antibiotic application in postoperative endophthalmitis].
abstract: OBJECTIVE
  Pars plana vitrectomy with intravitreal antibiotic application is an established procedure for treating postoperative endophthalmitis. The presented study analyzes our own results with this treatment as well as the role of adjuvant systemic steroid treatment.
  
  
  METHODS
  We analyzed the data of 34 consecutive patients with postoperative endophthalmitis from January 2000 to March 2006. Thirty-two patients underwent vitrectomy and intravitreal application of antibiotics, and two patients received intravitreal antibiotics only. All patients received intravitreal dexamethasone and systemic antibiotics, and 12 patients received the systemic treatment with prednisolone. The effect of vitrectomy with respect to final visual acuity and the rate of postoperative complications were analyzed. The vitreous was microbiologically examined. Postoperative follow-up time ranged from 2 weeks to 24 months.
  
  
  RESULTS
  Endophthalmitis followed cataract surgery with intraocular lens implantation in 30 patients (89%) and followed pars plana vitrectomy in four patients (11%). Positive cultures were obtained in 19 (56%) patients. Visual acuity improved in 31 (91%) patients. At their final examinations, 27 (79%) patients had gained visual acuity of 0.05 or better.
  
  
  CONCLUSIONS
  
  
  
  CONCLUSIONS
  Immediate vitrectomy in combination with intraocular antibiotics and steroid administration resulted in preservation of ambulatory vision in most of the patients. Systemic postoperative therapy with steroids seems to be associated with better final visual acuity.
authors: Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum AöR, Universität Leipzig, Liebigstrasse 10-14, 04103, Leipzig.
authors: M
authors: M
authors: Rehak
authors: R
authors: R
authors: Blatz
authors: P
authors: P
authors: Wiedemann
authors: P
authors: P
authors: Meier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D009877:Endophthalmitis / Q000209:etiology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000009:adverse effects*; D011182:Postoperative Care / Q000379:methods; D013256:Steroids / Q000008:administration & dosage*; D014821:Vitrectomy
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D013256:Steroids
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