Noninvasive measurements of arterial stiffness: repeatability and interrelationships with endothelial function and arterial morphology measures.
BACKGROUND
Many noninvasive arterial assessment techniques have been developed, measuring different parameters of arterial stiffness and endothelial function. However, there is little data available comparing different devices within the same subject. Therefore, the purpose of this study was to examine the repeatability and interrelationships between 3 different techniques to measure arterial stiffness and to compare this with forearm-mediated dilation.


METHODS
Carotid-radial pulse wave velocity was measured by the Sphygmocor (SPWV) and Complior (CPWV) devices, cardio-ankle vascular index (CAVI) was measured by the VaSera device, vascular structure and function was assessed using ultrasonography and evaluated for reliability and compared in 20 apparently healthy, college-aged men and women.


RESULTS
The intraclass correlation coefficient and standard error of the mean for the Sphygmocor (R = 0.56, SEM = 0.69), Complior (R = 0.62, SEM = 0.69), and VaSera (R = 0.60, SEM = 0.56), indicated moderate repeatability. Bland-Altman plots indicated a mean difference of 0.11 +/- 0.84 for SPWV, 0.13 +/- 1.15 for CPWV, and -0.43 +/- 0.90 for CAVI. No significant interrelationships were found among the ultrasound measures and SPWV, CPWV, and CAVI.


CONCLUSIONS
The three noninvasive modalities to study arterial stiffness reliably measures arterial stiffness however, they do not correlate with ultrasound measures of vascular function and structure in young and apparently healthy subjects.
Huck
Corey J
CJ
School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA.
Bronas
Ulf G
UG
Williamson
Eric B
EB
Draheim
Christopher C
CC
Duprez
Daniel A
DA
Dengel
Donald R
DR
D000293:Adolescent; D000328:Adult; D000842:Ankle / Q000098:blood supply; D001158:Arteries / Q000000981:diagnostic imaging / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology*; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D005542:Forearm / Q000098:blood supply; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D011674:Pulse / Q000295:instrumentation* / Q000379:methods; D013673:Technology Assessment, Biomedical; D014463:Ultrasonography
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