Therapy-related acute myelogenous leukemia and myelodysplastic syndrome.
Therapy-related acute myelogenous leukemia and myelodysplastic syndrome (t-AML/MDS) are increasing in prevalence with aging of the population and improved survival of patients treated with chemotherapy or radiotherapy for other malignancies. Research focused on the pathogenesis of t-AML/MDS will provide insight into the pathogenesis of de novo AML/MDS. Participation in clinical trials should be encouraged for this patient population because results with available treatment options are clearly suboptimal.
Borthakur
Gautam
G
Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. GBorthak@mdanderson.org
Estey
And Elihu E
AE
D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000139:chemically induced* / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000473:pathology; D011379:Prognosis
D000970:Antineoplastic Agents
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