[Clinical typing and diagnosis of sporadic human prion diseases (classic sproadic CJD, MM2-cortical form CJD, MM2-thalamic form CJD)].
We described recent knowledge and outline about a diagnosis and clinical typing of sporadic prion disease. Diagnostic procedure and classification based on a pattern of Western blotting of PrP(Sc), neuropathologic findings, and clinical features. In addition, we described a clinical significance of total tau protein, significance of a diffusion-weighted images of MRI. Analysis of 112 cases of sporadic prion diseases showed 92.3% at positive rate. Sensitivity and specificity were 95.5% and 95.7%, respectively by total tau protein assay of 44 cases of prion diseases.
Satoh
Katsuya
K
First Department of Internal Medicine, Graduate School of Biomedical Science, Nagasaki University.
Shirabe
Susumu
S
Eguchi
Katsumi
K
D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000032:analysis / Q000134:cerebrospinal fluid; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism; D007562:Creutzfeldt-Jakob Syndrome / Q000145:classification* / Q000175:diagnosis* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D004569:Electroencephalography; D006801:Humans; D018620:PrPSc Proteins / Q000032:analysis; D016875:tau Proteins / Q000134:cerebrospinal fluid
D048948:14-3-3 Proteins; D015415:Biomarkers; D018620:PrPSc Proteins; D016875:tau Proteins