title: White matter volume as a major predictor of cognitive function in Sturge-Weber syndrome.
abstract: OBJECTIVE
  To assess the role of gray and white matter volume loss vs seizures in cognitive impairment of children with Sturge-Weber syndrome with unilateral involvement.
  
  
  METHODS
  Patients were enrolled in this prospective cohort during a period of 3 years.
  
  
  METHODS
  Pediatric neurology clinic with national referral through the Sturge-Weber Foundation.
  
  
  METHODS
  Twenty-one children (age range, 1 year 6 months to 10 years 4 months) with unilateral Sturge-Weber syndrome.
  
  
  METHODS
  Cortical gray matter and hemispheric white matter volumes were measured on segmented volumetric magnetic resonance imaging and correlated with the age of the participants. Global intellectual function (IQ) was correlated with magnetic resonance imaging and seizure variables in both univariate and multivariate analyses.
  
  
  RESULTS
  Both gray and white matter volumes showed an age-related linear increase. Tissue volumes on the side of the angioma showed a positive correlation with IQ after controlling for age in univariate regression analyses (white matter, r = 0.71, P < .001; gray matter, r = 0.48, P = .03), while seizure variables did not correlate with IQ (P > .1). A multivariate regression showed that hemispheric white matter volume ipsilateral to the angioma was an independent predictor of IQ (R = 61, P = .006), which also showed a negative correlation with age (R = - 0.52, P = .022) but no correlation with gray matter volumes.
  
  
  CONCLUSIONS
  Early hemispheric white matter loss may play a major role in cognitive impairment in children with Sturge-Weber syndrome. Future therapeutic approaches should aim at preserving white matter integrity in addition to seizure control to improve cognitive outcome.
authors: Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA. juhasz@pet.wayne.edu
authors: Csaba
authors: C
authors: Juhasz
authors: Christopher
authors: C
authors: Lai
authors: Michael E
authors: ME
authors: Behen
authors: Otto
authors: O
authors: Muzik
authors: Emily J
authors: EJ
authors: Helder
authors: Diane C
authors: DC
authors: Chugani
authors: Harry T
authors: HT
authors: Chugani
mesh_terms: D000375:Aging; D001921:Brain / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003071:Cognition; D004827:Epilepsy / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D007360:Intelligence; D008279:Magnetic Resonance Imaging; D008297:Male; D009068:Movement; D012640:Seizures / Q000209:etiology; D013341:Sturge-Weber Syndrome / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology*