title: A novel analgesic pyrazine derivative from the leaves of Croton tiglium L.
abstract: A novel analgesic pyrazine derivative, named crotonine, was isolated from the leaves of Croton tiglium L. The structure was elucidated as 2-(furan-2-yl)-5-(2,3,4-trihydroxy-butyl)-1,4-diazine by spectroscopic analysis. Crotonine inhibited remarkably the acetic acid-induced writhing in mice.
authors: Laboratory of Phytochemistry, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
authors: Xin-An
authors: XA
authors: Wu
authors: Yi-Min
authors: YM
authors: Zhao
authors: Neng-Jiang
authors: NJ
authors: Yu
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D029802:Croton / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry*; D011719:Pyrazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C525327:2-(furan-2-yl)-5-(2,3,4-trihydroxybutyl)-1,4-diazine; D000700:Analgesics; D011719:Pyrazines