Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis.
Che-1/AATF (Che-1) was originally characterized as an interacting protein for RNA polymerase II. In addition to transcriptional regulation, the evidence suggests that Che-1 has a viral factor-like S phase promoting role in counteracting Rb repression to facilitate E2F-dependent transactivation during G1-S transition. Recently, Che-1 was found to play an important role in the DNA damage response and cell-cycle checkpoint control. Genetic studies in mice revealed that Che-1 is essential for preimplantation development and the establishment of embryonic gene expression. Importantly, several findings showed that Che-1 participates in inhibiting apoptotic process. Thus, Che-1 emerges as an important adaptor that connects transcriptional regulation, cell-cycle progression, checkpoint control, and apoptosis.
Passananti
Claudio
C
Istituto di Biologia e Patologia Molecolare, CNR, 00158 Rome, Italy.
Floridi
Aristide
A
Fanciulli
Maurizio
M
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology*; D005786:Gene Expression Regulation; D018816:Genes, cdc; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D008969:Molecular Sequence Data; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
C402637:AATF protein, human; D051017:Apoptosis Regulatory Proteins; D012097:Repressor Proteins; D014157:Transcription Factors