Archaeosomes based on synthetic tetraether-like lipids as novel versatile gene delivery systems.
Novel cationic liposomes, termed "archaeosomes", based on mixtures of neutral/cationic bilayer-forming lipids and archaeobacterial synthetic tetraether-type bipolar lipids show efficient in vitro gene transfection properties and represent a new approach for modulating the lipidic membrane fluidity of the complexes they form with DNA.
Réthoré
G
G
ENSCR, UMR CNRS 6226 Sciences Chimiques de Rennes, Equipe Synthèse Organique et Systèmes Organises, 35700 Rennes, France.
Montier
T
T
Le Gall
T
T
Delépine
P
P
Cammas-Marion
S
S
Lemiègre
L
L
Lehn
P
P
Benvegnu
T
T
D002412:Cations / Q000737:chemistry; D045744:Cell Line, Tumor; D004247:DNA / Q000235:genetics; D005995:Glyceryl Ethers / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D008081:Liposomes; D015394:Molecular Structure; D010957:Plasmids / Q000235:genetics; D014162:Transfection / Q000379:methods*
D002412:Cations; D005995:Glyceryl Ethers; D008081:Liposomes; C094417:archaeol lipid; D004247:DNA