title: Identification and molecular characterization of multiple phenotypes in integrin knockout mice.
abstract: Each of the 24 known integrin subunits has now been inactivated in mice, and a growing number of conditional null lines are becoming available. Lines of mice expressing null mutations in integrin subunit genes have taught us a great deal about the remarkably diverse functions that integrins perform in vivo in mammals. Thorough evaluation of the phenotypes manifested by these lines has also revealed a number of previously unexpected integrin ligands and signaling partners. In this article, we review approaches that can contribute to optimal use of this valuable resource.
authors: Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
authors: Chun
authors: C
authors: Chen
authors: Dean
authors: D
authors: Sheppard
mesh_terms: D000818:Animals; D016023:Integrins / Q000145:classification / Q000235:genetics* / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008967:Molecular Biology / Q000379:methods; D010641:Phenotype
chemical_list: D016023:Integrins