title: Cyclin D1 expression and histopathologic features in vestibular schwannomas.
abstract: OBJECTIVE
  To evaluate cyclin D1 expression in vestibular schwannoma and its relationship with histologic, clinical, and radiologic features.
  
  
  METHODS
  Twenty-one patients with histologically confirmed vestibular schwannoma.
  
  
  METHODS
  Immunohistochemistry analysis was performed with anticyclin D1. Histopathologic features studied included Antoni pattern and nuclear and stromal degenerative changes. Clinical charts, audiometric data, and magnetic resonance imaging characteristics were reviewed.
  
  
  METHODS
  Cyclin D1 expression and its association with histologic, clinical, and radiologic findings.
  
  
  RESULTS
  Cyclin D1 expression was found in 52% of cases. Cyclin D1 expression was more frequent in right-sided tumors (p = 0.02) and in tumors with nuclear degenerative changes (p < 0.0001). Patients with negative cyclin D1 expression had longer duration of deafness (p = 0.02) and higher 2,000-Hz hearing thresholds (p = 0.04) than cyclin D1+ patients.
  
  
  CONCLUSIONS
  Cyclin D1 expression, present in nearly half of the cases, may play a role in the development of these tumors. Further studies are needed to fully understand the contributions of histopathologic and immunohistochemical factors to vestibular schwannoma biological activity.
authors: Department of Otolaryngology, Laboratorio Oncogenetica Molecular, La Paz University Hospital, Madrid, Spain. luikilassa@yahoo.com
authors: Luis
authors: L
authors: Lassaletta
authors: Mercedes
authors: M
authors: Patrón
authors: Laura
authors: L
authors: Del Río
authors: Carolina
authors: C
authors: Alfonso
authors: Jose Maria
authors: JM
authors: Roda
authors: Juan A
authors: JA
authors: Rey
authors: Javier
authors: J
authors: Gavilan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001299:Audiometry; D003390:Cranial Nerve Neoplasms / Q000235:genetics* / Q000473:pathology*; D003638:Deafness / Q000209:etiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D019940:Genes, bcl-1 / Q000235:genetics*; D034381:Hearing Loss / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000235:genetics* / Q000473:pathology*; D016612:Paraffin Embedding; D014726:Vestibular Nuclei / Q000473:pathology; D000160:Vestibulocochlear Nerve Diseases / Q000235:genetics* / Q000473:pathology*