title: Executive function is associated with brain proton magnetic resonance spectroscopy in amnestic mild cognitive impairment.
abstract: Persons with amnestic mild cognitive impairment (MCI) show deficits on executive function measures, although the neuroanatomic basis of executive function in MCI is unknown. We investigated cognitive correlates of 3-tesla proton magnetic resonance spectroscopy (MRS) of the posterior cingulate gyrus in 26 MCI patients. Posterior cingulate ratio of myo-inositol to creatine (mI/Cr) was negatively correlated (-.51) with spontaneous clock drawing. This relationship was not attenuated after accounting for age, overall cognitive function, or memory performance. This finding suggests a role for the posterior cingulate in executive function in MCI. Proton MRS may offer a means to track neurometabolic changes associated with cognitive impairment in MCI.
authors: Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. rlgriffith@uabmc.edu
authors: H Randall
authors: HR
authors: Griffith
authors: Jan A den
authors: JA
authors: Hollander
authors: Ozioma
authors: O
authors: Okonkwo
authors: William T
authors: WT
authors: Evanochko
authors: Lindy E
authors: LE
authors: Harrell
authors: Edward Y
authors: EY
authors: Zamrini
authors: John C
authors: JC
authors: Brockington
authors: Daniel C
authors: DC
authors: Marson
mesh_terms: D000368:Aged; D000647:Amnesia / Q000150:complications* / Q000473:pathology; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000150:complications* / Q000473:pathology; D003401:Creatine / Q000032:analysis; D005260:Female; D006179:Gyrus Cinguli / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007294:Inositol / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology*; D011522:Protons
chemical_list: D011522:Protons; D007294:Inositol; D003401:Creatine