Sensory neural targets for the treatment of cough.
1. Cough is a primary defensive reflex that protects the airways from potentially harmful stimuli. 2. During many respiratory diseases, the cough reflex threshold is lowered and coughing becomes excessive. 3. Currently available therapeutics are mostly ineffective at suppressing excessive coughing. 4. In the present review, we describe the sensory neural pathways involved in cough, how these pathways may become dysfunctional in airway disease and the most recent advances that have been made in identifying future targets for cough suppression.
Mazzone
Stuart B
SB
Howard Florey Institute, University of Melbourne, Melbourne, Victoria, Australia. smazzone@florey.edu.au
McGovern
Alice E
AE
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology*; D018118:Chloride Channels / Q000037:antagonists & inhibitors; D003371:Cough / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D009475:Neurons, Afferent / Q000187:drug effects*; D012018:Reflex / Q000502:physiology; D026941:Sodium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use; D049994:Sodium Potassium Chloride Symporter Inhibitors; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors
D000996:Antitussive Agents; D018118:Chloride Channels; D026941:Sodium Channel Blockers; D049994:Sodium Potassium Chloride Symporter Inhibitors; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D000254:Sodium-Potassium-Exchanging ATPase