title: Antiobesity properties of two African plants (Afromomum meleguetta and Spilanthes acmella) by pancreatic lipase inhibition.
abstract: Ethanol extracts of seeds of Afromomum meleguetta and flower buds of Splilanthes acmella presented pancreatic lipase inhibitory activities in a concentration related manner under in vitro conditions. The two plants were extracted with 70% ethanol by sonication, fractionated on silica gel and tested at concentrations in the range 0.75-2.0 mg/mL. Lipase inhibitory activities of 90% and 40% were observed in A. meleguetta and S. acmella, respectively. The two plants have potentials as candidates for weight reduction and obesity control.
authors: Institute of Oceanography, University of Calabar, P.M.B. 1115, Calabar, Nigeria. albertekanem@yahoo.com
authors: A P
authors: AP
authors: Ekanem
authors: M
authors: M
authors: Wang
authors: J E
authors: JE
authors: Simon
authors: D A
authors: DA
authors: Moreno
mesh_terms: D019440:Anti-Obesity Agents / Q000032:analysis* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D004041:Dietary Fats / Q000378:metabolism; D035264:Flowers / Q000737:chemistry; D008049:Lipase / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D019440:Anti-Obesity Agents; D004041:Dietary Fats; D010936:Plant Extracts; D008049:Lipase; C518354:PNLIP protein, human