Endovascular cooling in a patient with neuroleptic malignant syndrome.
We report a case of severe neuroleptic malignant syndrome with hyperthermia, rhabdomyolysis and hepatic failure where we applied endovascular cooling in order to reverse hyperthermia. After rapid normalization of core temperature at 37.5 degrees C, the patient's condition improved and CK levels dropped. However, upon withdrawl of endovascular temperature control there was a relapse. This is the first case where endovascular cooling was applied successfully in neuroleptic malignant syndrome.
Diedler
Jennifer
J
Department of Neurology, University of Heidelberg, Germany. jennifer.diedler@med.uni-heidelberg.de
Mellado
Patricio
P
Veltkamp
Roland
R
D014150:Antipsychotic Agents / Q000506:poisoning; D002408:Catheters, Indwelling; D003402:Creatine Kinase / Q000097:blood; D004357:Drug Synergism; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy*; D006220:Haloperidol / Q000506:poisoning*; D006634:Histamine H1 Antagonists / Q000506:poisoning; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000503:physiopathology; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000150:complications* / Q000503:physiopathology*; D011398:Promethazine / Q000506:poisoning*; D012008:Recurrence; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000503:physiopathology; D013406:Suicide, Attempted; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D006634:Histamine H1 Antagonists; D003402:Creatine Kinase; D011398:Promethazine; D006220:Haloperidol