title: Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation.
abstract: The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to degradation of the extracellular matrix; however, in recent years, it has become evident that these proteases can modify many nonmatrix substrates, such as cytokines and chemokines. The use of MMP-deficient animals has revealed that these proteases can indeed influence the progression of various inflammatory processes. This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration.
authors: Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium.
authors: Philippe
authors: P
authors: Van Lint
authors: Claude
authors: C
authors: Libert
mesh_terms: D000818:Animals; D002465:Cell Movement; D018925:Chemokines / Q000378:metabolism*; D006801:Humans; D007249:Inflammation; D007962:Leukocytes / Q000166:cytology* / Q000201:enzymology*; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
chemical_list: D018925:Chemokines; D020782:Matrix Metalloproteinases