title: Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.
abstract: We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.
authors: Laboratory of Vaccine-Preventable Diseases, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
authors: Sander
authors: S
authors: Banus
authors: Renske W B
authors: RW
authors: Bottema
authors: Christine L E
authors: CL
authors: Siezen
authors: Rob J
authors: RJ
authors: Vandebriel
authors: Johan
authors: J
authors: Reimerink
authors: Monique
authors: M
authors: Mommers
authors: Gerard H
authors: GH
authors: Koppelman
authors: Barbara
authors: B
authors: Hoebee
authors: Carel
authors: C
authors: Thijs
authors: Dirkje S
authors: DS
authors: Postma
authors: Tjeerd G
authors: TG
authors: Kimman
authors: Foekje F
authors: FF
authors: Stelma
mesh_terms: D000818:Animals; D015331:Cohort Studies; D006801:Humans; D007110:Immunity, Active / Q000235:genetics; D007223:Infant; D051379:Mice; D008809:Mice, Inbred C3H; D010567:Pertussis Vaccine / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide; D051197:Toll-Like Receptor 4 / Q000235:genetics* / Q000502:physiology; D014613:Vaccines, Attenuated / Q000276:immunology
chemical_list: D010567:Pertussis Vaccine; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D014613:Vaccines, Attenuated
references: J Clin Microbiol. 2000 Feb;38(2):800-6
references: 10655388
references: Community Genet. 2007;10(4):201-17
references: 17895626
references: Nat Genet. 2000 Jun;25(2):187-91
references: 10835634
references: J Infect Dis. 2000 Jun;181(6):2087-91
references: 10837200
references: J Infect Dis. 2000 Nov;182(5):1575-7
references: 11023488
references: Infect Immun. 2002 Aug;70(8):4600-8
references: 12117973
references: J Infect Dis. 2002 Nov 15;186(10):1522-5
references: 12404174
references: J Immunol. 2003 Sep 15;171(6):3119-27
references: 12960338
references: Arch Pediatr Adolesc Med. 1997 Mar;151(3):283-9
references: 9080938
references: Infect Immun. 1998 Feb;66(2):594-602
references: 9453614
references: Vaccine. 1998 Dec;16(20):1901-6
references: 9796041
references: Vaccine. 1998 Dec;16(20):1907-16
references: 9796042
references: Science. 1998 Dec 11;282(5396):2085-8
references: 9851930
references: Infect Immun. 1999 Aug;67(8):4064-71
references: 10417175
references: J Immunol. 2004 Dec 1;173(11):7070-7
references: 15557205
references: Bioinformatics. 2005 Jan 15;21(2):263-5
references: 15297300
references: Infect Immun. 2005 Feb;73(2):741-7
references: 15664912
references: BMC Public Health. 2005 Jan 3;5:1
references: 15627405
references: Lancet Infect Dis. 2005 Mar;5(3):156-64
references: 15766650
references: Ned Tijdschr Geneeskd. 2005 Apr 23;149(17):937-43
references: 15884408
references: Trends Immunol. 2005 Jun;26(6):289-91
references: 15922942
references: Infect Immun. 2005 Dec;73(12):8144-52
references: 16299309
references: Pediatr Allergy Immunol. 2005 Dec;16(8):679-84
references: 16343090
references: Infect Immun. 2006 May;74(5):2596-605
references: 16622195
references: Clin Immunol. 2006 Jul;120(1):1-9
references: 16563867
references: J Immunol. 2006 Dec 1;177(11):7980-9
references: 17114471
references: J Infect Dis. 2000 Mar;181(3):1010-3
references: 10720524