Nonclassical protein sorting.
Recent characterization of the major protein-targeting systems in both yeast and mammalian cells has provided detailed descriptions of how cellular transport processes operate. Increasingly, however, novel protein-sorting mechanisms are being uncovered. These newly discovered 'alternative' mechanisms of protein sorting ensure accurate delivery of numerous cellular constituents either to their resident compartment or, in many cases, to the cellular protein-degradation machinery. Like the better characterized 'classical' protein-sorting systems, 'nonclassical' targeting mechanisms involve both membrane translocation through protein channels and vesicle-mediated transport. This review discusses our current understanding of these nonclassical protein-sorting pathways and their role in eukaryotic cells.
Klionsky
D J
DJ