title: Strong and independent prognostic value of peak circulatory power in adults with congenital heart disease.
abstract: BACKGROUND
  The identification of patients with adult congenital heart disease (ACHD) who are at higher risk of death is challenging. Peak circulatory power (CircP; expressed as peak exercise oxygen uptake multiplied for peak mean arterial blood pressure) is a strong predictor of death in adults with acquired heart disease. We sought to establish the distribution and the prognostic value of peak CircP across a wide spectrum of patients with ACHD.
  
  
  METHODS
  Four hundred thirty-two consecutive patients with ACHD of varying diagnosis underwent cardiopulmonary exercise testing at a single laboratory between 1996 and 2005. Patient age was 32 +/- 10 years.
  
  
  RESULTS
  A gradual variation in peak CircP was found across the spectrum of congenital heart defects (P < .0001 at analysis of variance). Reduced peak CircP values were associated with the presence of heart failure symptoms (P < .0001), absence of sinus rhythm (P = .010), and use of antiarrhythmic medications (P = .0013). At a follow-up of 4.4 +/- 2.4 years, 23 patients (5.3%) had died. Peak CircP was a strong predictor of mortality when univariate analysis was used and the strongest independent predictor of mortality among exercise parameters. A peak CircP < or = 1476 mm Hg mlO2 min(-1) kg(-2) was associated with a 15.4-fold increase in the 4-year risk of death.
  
  
  CONCLUSIONS
  Peak CircP is abnormal across the spectrum of ACHD. Peak CircP appears as the strongest predictor of adverse outcome in ACHD.
authors: Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Bologna, Italy. alessandro5574@iol.it
authors: Alessandro
authors: A
authors: Giardini
authors: Salvatore
authors: S
authors: Specchia
authors: Emanuela
authors: E
authors: Berton
authors: Diego
authors: D
authors: Sangiorgi
authors: Gloria
authors: G
authors: Coutsoumbas
authors: Gaetano
authors: G
authors: Gargiulo
authors: Guido
authors: G
authors: Oppido
authors: Marco
authors: M
authors: Bonvicini
authors: Fernando M
authors: FM
authors: Picchio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005080:Exercise Test; D006331:Heart Diseases / Q000151:congenital* / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D011379:Prognosis