Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago.
The population of Trinidad and Tobago is composed mainly of people of East Indian (Indo-Trinidadians) and African (Afro-Trinidadians) ancestry. Differences in alcoholism rates exist between these two ethnic groups, and researchers have investigated whether these differences can be explained in part by variations in the genes encoding the alcohol-metabolizing enzymes alcohol dehydrogenase (ADH) 1B and 1C, and aldehyde dehydrogenase (ALDH) 1 and 2. Studies have demonstrated that a certain variant of the gene encoding ADH1B (ADH1B*3) is associated with a reduced risk of alcoholism in Afro-Trinidadians, as is a variant of the gene encoding ADH1C (i.e., ADH1C*1) in Indo-Trinidadians. An ALDH2 variant shown to have protective effects primarily in East Asians was not found in either Trinidadian ethnic group. However, a variant in the gene encoding cytosolic ALDH1A (i.e. ALDH1A1*1/*2) was found to be associated with an increase in alcohol dependence in Indo-Trinidadians.
Moore
Shelley
S
Department of Pharmacology, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Montane-Jaime
L K
LK
Carr
Lucinda G
LG
Ehlers
Cindy L
CL
D000426:Alcohol Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D000437:Alcoholism / Q000201:enzymology / Q000208:ethnology* / Q000235:genetics; D000444:Aldehyde Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D044466:Asian People / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D000431:Ethanol / Q000378:metabolism*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D014644:Genetic Variation; D006801:Humans; D014300:Trinidad and Tobago / Q000453:epidemiology
D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase
J Stud Alcohol Drugs. 2007 Mar;68(2):192-6
17286337
J Stud Alcohol. 2000 Jan;61(1):5-12
10627090
Pathol Biol (Paris). 2001 Nov;49(9):703-9
11762132
Pharmacogenetics. 2003 Jun;13(6):321-8
12777962
Alcohol Clin Exp Res. 2007 Feb;31(2):216-20
17250612
Prog Liver Dis. 1995;13:151-72
9224501
Hepatology. 2006 Feb;43(2):352-61
16440362
Alcohol. 2006 Jun;39(2):81-6
17134660
Alcohol Clin Exp Res. 1992 Oct;16(5):991-5
1443441