Antinociceptive effect from Davilla elliptica hydroalcoholic extract.
Davilla elliptica St Hill (Dilleniaceae) is widely used for multiple purposes in Brazil. The aim of this study was to verify the pharmacological support of this folk use and evaluate its use as antinociceptive. The hydroalcoholic extract of the stems (100-1000 mg/kg, p.o.) induced reduction of response in the formalin test inflammatory phase in mice. This antinociceptive effect does not involve the opioidergic pathway since it was not reverted by pre-treatment with naloxone nor due to myorelaxant activity since it did not affect rota-rod and tail-flick performance. Our results indicate a participation of the nitrergic pathway and may be of particular potential importance in clinical medicine, in view of the current interest in the assessment of new medicines originated from plants.
Azevedo
A O
AO
Department of Pharmacology, UFMG (Federal University of Minas Gerais), Brazil.
Campos
J J
JJ
Galdino
G S
GS
Braga
F C
FC
Duarte
I D G
ID
Perez
A C
AC
D000284:Administration, Oral; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001938:Brazil; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D004008:Diclofenac / Q000008:administration & dosage / Q000494:pharmacology; D045466:Dilleniaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D000431:Ethanol / Q000737:chemistry; D005557:Formaldehyde / Q000008:administration & dosage / Q000633:toxicity; D006614:Hindlimb; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement / Q000379:methods; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D014867:Water / Q000737:chemistry
D000700:Analgesics; D016861:Cyclooxygenase Inhibitors; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014867:Water; D004008:Diclofenac; D005557:Formaldehyde; D000431:Ethanol; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester