Effect of influenza vaccine status on winter mortality in Spanish community-dwelling elderly people during 2002-2005 influenza periods.
This study assessed the relationship between the reception of conventional inactivated influenza vaccine and winter mortality in a prospective cohort that included 11,240 Spanish community-dwelling elderly individuals followed from January 2002 to April 2005. Annual influenza vaccine status was a time-varying condition and primary outcome was all-cause death during study period. Multivariable Cox proportional-hazard models adjusted by age, sex and co-morbidity were used to evaluate vaccine effectiveness. Influenza vaccination was associated with a significant reduction of 23% in winter mortality risk during overall influenza periods. The attributable mortality risk in non-vaccinated people was 24 deaths per 100,000 persons-week within influenza periods, the prevented fraction for the population was 14%, and one death was prevented for every 239 annual vaccinations (ranging from 144 in Winter 2005 to 1748 in Winter 2002).
Vila-Córcoles
Angel
A
Primary Care Service of Tarragona-Valls, Institut Català de la Salut, Tarragona, Spain. avila.tarte.ics@gencat.net
Rodriguez
Teresa
T
de Diego
Cinta
C
Ochoa
Olga
O
Valdivieso
Amparo
A
Salsench
Elisabet
E
Ansa
Xabier
X
Badía
Waleska
W
Saún
Neus
N
D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology* / Q000401:mortality* / Q000517:prevention & control; D008297:Male; D012307:Risk Factors; D012621:Seasons; D013030:Spain / Q000453:epidemiology; D013997:Time Factors
D007252:Influenza Vaccines