[Role of platelet-derived growth factor in the pathogenesis of preeclampsia].
OBJECTIVE
To study the role of platelet-derived growth factor (PDGF) in the pathogenesis of preeclampsia (PRE).


METHODS
Thirteen normal and 20 PRE late-pregnancy women were enrolled in this study. The serum PDGF-BB levels were measured with enzyme-linked immunosorbent assay, and the expression of PDGF-B mRNA in the decidual blood vessel was determined using in situ hybridization.


RESULTS
PDGF-BB levels in PRE group was significantly higher than that in normal pregnant women (83.54 -/+34.52 vs 39.61-/+18.20, P<0.001), and the expression of PDGF-B mRNA in decidual blood vessel was also significantly higher in PRE group (P<0.001), showing a positive correlation between serum PDGF and PDGF-B mRNA expression (r=0.603, P<0.001).


CONCLUSIONS
PDGF is associated with the pathology of decidual blood vessel. Elevated serum PDGF levels and PDGF-B mRNA expression in the decidual blood vessel may play an important role in the pathogenesis of PRE.
Meng
Hui
H
Department of Obstetrics and Gynecology, Guangzhou Women and Children's Hospital, Guangzhou 510180, China. mhwd2@hotmail.com
Zhu
Fu-Fan
FF
Wang
Chen-Hong
CH
Xiao
Gen-Xiu
GX
D000328:Adult; D000077214:Becaplermin; D003656:Decidua / Q000098:blood supply; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D011247:Pregnancy; D020574:Proto-Oncogene Proteins c-sis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D012333:RNA, Messenger; D000077214:Becaplermin