Thottapalayam virus is genetically distant to the rodent-borne hantaviruses, consistent with its isolation from the Asian house shrew (Suncus murinus).
Thottapalayam (TPM) virus belongs to the genus Hantavirus, family Bunyaviridae. The genomes of hantaviruses consist of three negative-stranded RNA segments (S, M and L) encoding the virus nucleocapsid (N), glycoprotein (Gn, Gc), and polymerase (L) proteins, respectively. The genus Hantavirus contains predominantly rodent-borne viruses, with the prominent exception of TPM virus which was isolated in India in 1964 from an insectivore, Suncus murinus, commonly referred to as the Asian house shrew or brown musk shrew. Analysis of the available TPM virus S (1530 nt) RNA genome segment sequence and the newly derived M (3621 nt) and L (6581 nt) segment sequences demonstrate that the entire TPM virus genome is very unique. Remarkably high sequence differences are seen at the nucleotide (up to S - 47%, M - 49%, L - 38%) and protein (up to N - 54%, Gn/Gc - 57% and L - 39%) levels relative to the rodent-borne hantaviruses, consistent with TPM virus having a unique host association.
Yadav
Pragya D
PD
Special Pathogen Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. yadavpd@icmr.org.in
Vincent
Martin J
MJ
Nichol
Stuart T
ST
D000818:Animals; D014644:Genetic Variation; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D012377:Rodentia / Q000821:virology*; D012788:Shrews / Q000821:virology*
Curr Top Microbiol Immunol. 2001;256:47-75
11217406
Emerg Infect Dis. 2007 Jul;13(7):980-5
18214168
J Virol. 2004 May;78(10):5414-22
15113920
Indian J Med Res. 1971 Nov;59(11):1758-60
5169031
Arch Virol. 1989;108(3-4):211-27
2690776
Virology. 1994 Jan;198(1):196-204
8259655
Virology. 1994 Jan;198(1):205-17
8259656
Virology. 1994 May 1;200(2):715-23
8178455
Arch Virol. 2005 Mar;150(3):533-56
15503219
J Virol. 2005 Aug;79(15):10032-9
16014963
Indian J Med Res. 2005 Sep;122(3):193-5
16251773
Indian J Med Res. 2005 Sep;122(3):211-5
16251777
Curr Mol Med. 2005 Dec;5(8):773-90
16375712
J Virol. 2006 Sep;80(18):9073-81
16940519
Virus Genes. 2006 Oct;33(2):169-74
16972031
Antioxid Redox Signal. 2007 Jan;9(1):25-47
17115886
Am J Trop Med Hyg. 2006 Nov;75(5):1003-10
17124003
Clin Vaccine Immunol. 2007 Feb;14(2):173-81
17182762
J Mol Biol. 2007 Mar 9;366(5):1538-44
17222867
Emerg Infect Dis. 2007 Mar;13(3):520-2
17554814
Virology. 2001 Oct 25;289(2):224-9
11689045