Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry.
BACKGROUND
This article reports demographic characteristics and intensive care unit survival for 344 patients from the Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry, a voluntary multicenter observational network.


METHODS
Ages were newborn to 25 yr, 58% were male, and weights were 1.3 to 160 kg. Patients spent a median of 2 d in the intensive care unit before CRRT (range 0 to 135). At CRRT initiation, 48% received diuretics and 66% received vasoactive drugs. Mean blood flow was 97.9 ml/min (range 10 to 350 ml/min; median 100 ml/min); mean blood flow per body weight was 5 ml/min per kg (range 0.6 to 53.6 ml/min per kg; median 4.1 ml/min per kg). Days on CRRT were <1 to 83 (mean 9.1; median 6). A total of 56% of circuits had citrate anticoagulation, 37% had heparin, and 7% had no anticoagulation.


RESULTS
Overall survival was 58%; survival differed across participating centers. Survival was lowest (51%) when CRRT was started for combined fluid overload and electrolyte imbalance. There was better survival in patients with principal diagnoses of drug intoxication (100%), renal disease (84%), tumor lysis syndrome (83%), and inborn errors of metabolism (73%); survival was lowest in liver disease/transplant (31%), pulmonary disease/transplant (45%), and bone marrow transplant (45%). Overall survival was better for children who weighed >10 kg (63 versus 43%; P = 0.001) and for those who were older than 1 yr (62 versus 44%; P = 0.007).


CONCLUSIONS
CRRT can be used successfully for a wide range of critically ill children. Survival is best for those who have acute, specific abnormalities and lack multiple organ involvement; sicker patients with selected diagnoses may have lower survival. Center differences might suggest opportunities to define best practices with future study.
Symons
Jordan M
JM
Department of Pediatrics, University of Washington School of Medicine and Children's Hospital & Regional Medical Center, Seattle, Washington 98105, USA. jordan.symons@seattlechildrens.org
Chua
Annabelle N
AN
Somers
Michael J G
MJ
Baum
Michelle A
MA
Bunchman
Timothy E
TE
Benfield
Mark R
MR
Brophy
Patrick D
PD
Blowey
Douglas
D
Fortenberry
James D
JD
Chand
Deepa
D
Flores
Francisco X
FX
Hackbarth
Richard
R
Alexander
Steven R
SR
Mahan
John
J
McBryde
Kevin D
KD
Goldstein
Stuart L
SL
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003710:Demography; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D012042:Registries; D017582:Renal Replacement Therapy / Q000379:methods* / Q000706:statistics & numerical data*