Modulating effect of Phyllanthus fruit extract against lead genotoxicity in germ cells of mice.
The objective of the present study was to evaluate the protective effect of Phyllanthus emblica against clastogenicity induced by lead nitrate on the incidence of sperm head abnormalities in the germ cells of mice. At higher concentration of lead, a significant increase in the percentage of sperm head abnormalities was noted but when animals primed with Phyllanthus fruit extract (PFE), a reduction in the frequency of sperm head abnormalities was observed. It can be suggested from the above study that Phyllanthus emblica plays a key role in inhibition of heavy metal mutagenesis in mammals.
Madhavi
D
D
Department of Zoology, College of Science, Osmania University, Hyderabad - 500 007, India. madhavi_sangam@yahoo.com
Devil
K Rudrama
KR
Rao
K Kesava
KK
Reddy
P P
PP
D000818:Animals; D005638:Fruit / Q000737:chemistry; D007854:Lead / Q000633:toxicity*; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D009566:Nitrates / Q000633:toxicity*; D029803:Phyllanthus / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology; D020011:Protective Agents / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology
D009153:Mutagens; D009566:Nitrates; D010936:Plant Extracts; D020011:Protective Agents; D007854:Lead; C017461:lead nitrate