title: Association between serum testosterone concentration and collagen degradation fragments in men with type 2 diabetes mellitus.
abstract: The aim of the present study was to evaluate relationships between serum endogenous androgens and urinary concentration of cross-linked N-telopeptides of type I collagen (NTx), a bone resorption marker, in men with type 2 diabetes mellitus because low androgen concentrations are associated with both osteoporosis and cardiovascular disease. Relationships between serum free testosterone and urinary NTx concentrations were investigated in 246 consecutive men with type 2 diabetes mellitus. In addition, relationships between urinary NTx concentration and other variables including age, duration of diabetes, blood pressure, serum lipid concentration, hemoglobin A(1c), and body mass index were evaluated. Urinary NTx concentrations were 27.8 (26.4-29.3) nmol of bone collagen equivalent per millimole of creatinine, correlating inversely with serum free testosterone (r = -0.263, P < .0001). Multiple regression analysis identified serum free testosterone (beta = -.292, P < .0001), hemoglobin A(1c) (beta = .144, P = .0404), and smoking status (beta = .143, P = .0402) as independent determinants of urinary NTx. In conclusion, serum free testosterone concentration correlated inversely with urinary NTx concentration, which may partly account for an observed link between osteoporosis and cardiovascular disease in men with type 2 diabetes mellitus.
authors: Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. sayarinapm@hotmail.com
authors: Michiaki
authors: M
authors: Fukui
authors: Hiroyuki
authors: H
authors: Ose
authors: Ichiko
authors: I
authors: Nakayama
authors: Hiroko
authors: H
authors: Hosoda
authors: Mai
authors: M
authors: Asano
authors: Mayuko
authors: M
authors: Kadono
authors: Shin-Ichi
authors: S
authors: Mogami
authors: Masahiro
authors: M
authors: Yamazaki
authors: Goji
authors: G
authors: Hasegawa
authors: Toshikazu
authors: T
authors: Yoshikawa
authors: Naoto
authors: N
authors: Nakamura
mesh_terms: D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D001862:Bone Resorption / Q000652:urine; D003094:Collagen / Q000378:metabolism*; D024042:Collagen Type I / Q000378:metabolism / Q000652:urine*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000503:physiopathology / Q000652:urine*; D003930:Diabetic Retinopathy / Q000097:blood / Q000652:urine; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000652:urine; D010455:Peptides / Q000378:metabolism / Q000652:urine*; D011499:Protein Processing, Post-Translational; D013739:Testosterone / Q000097:blood*
chemical_list: D003094:Collagen; D024042:Collagen Type I; D019314:Dehydroepiandrosterone Sulfate; D006442:Glycated Hemoglobin; D008055:Lipids; D010446:Peptide Fragments; D010455:Peptides; D013739:Testosterone; C052929:collagen type I trimeric cross-linked peptide; C517652:hemoglobin A1c protein, human