title: Inhibitory effect of lactone fractions and individual components from three species of the Achillea millefolium complex of Bulgarian origin on the human neutrophils respiratory burst activity.
abstract: Achillea species are widely used in folk medicine for treatment of inflammatory diseases. The inhibitory effect on the human neutrophils respiratory burst activity of total extracts, their fractions and some main constituents of the flower heads from Achillea asplenifolia, A. collina and A. distans belonging to A. millefolium complex of Bulgarian origin, were tested by the modified method of Tan and Berridge. Seven from the investigated fractions showed activity similar or higher than that of indomethacine and might be evaluated as nonsteroidal anti-inflammatory agents.
authors: H.E.J. Research Institute of Chemistry, International Center for Sciences, University of Karachi, Pakistan.
authors: Muhammad Iqbal
authors: MI
authors: Choudhary
authors: Saima
authors: S
authors: Jalil
authors: M
authors: M
authors: Todorova
authors: A
authors: A
authors: Trendafilova
authors: B
authors: B
authors: Mikhova
authors: H
authors: H
authors: Duddeck
authors: Atta-ur-Rahman
mesh_terms: D031162:Achillea / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002031:Bulgaria; D006801:Humans; D007213:Indomethacin / Q000493:pharmacokinetics / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008519:Medicine, Traditional; D009504:Neutrophils / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry*; D016897:Respiratory Burst
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D007213:Indomethacin