Role of modern chemistry in sustainable arable crop protection.
Organic chemistry has been, and for the foreseeable future will remain, vitally important for crop protection. Control of fungal pathogens, insect pests and weeds is crucial to enhanced food provision. As world population continues to grow, it is timely to assess the current situation, anticipate future challenges and consider how new chemistry may help meet those challenges. In future, agriculture will increasingly be expected to provide not only food and feed, but also crops for conversion into renewable fuels and chemical feedstocks. This will further increase the demand for higher crop yields per unit area, requiring chemicals used in crop production to be even more sophisticated. In order to contribute to programmes of integrated crop management, there is a requirement for chemicals to display high specificity, demonstrate benign environmental and toxicological profiles, and be biodegradable. It will also be necessary to improve production of those chemicals, because waste generated by the production process mitigates the overall benefit. Three aspects are considered in this review: advances in the discovery process for new molecules for sustainable crop protection, including tests for environmental and toxicological properties as well as biological activity; advances in synthetic chemistry that may offer efficient and environmentally benign manufacturing processes for modern crop protection chemicals; and issues related to energy use and production through agriculture.
Smith
Keith
K
Centre for Clean Chemistry, Department of Chemistry, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK. k.smith@swansea.ac.uk
Evans
David A
DA
El-Hiti
Gamal A
GA
D000383:Agriculture / Q000379:methods*; D016573:Agrochemicals / Q000009:adverse effects / Q000494:pharmacology*; D003247:Conservation of Natural Resources; D018556:Crops, Agricultural / Q000187:drug effects* / Q000254:growth & development; D017753:Ecosystem; D010572:Pest Control, Biological; D012680:Sensitivity and Specificity
D016573:Agrochemicals
Nat Rev Genet. 2006 Mar;7(3):174-84
16485017
Nat Rev Genet. 2002 Nov;3(11):883-9
12415318
Trends Genet. 2005 Oct;21(10):573-81
16099532
Chem Rev. 1999 Feb 10;99(2):355-390
11848985
Science. 2002 Apr 5;296(5565):92-100
11935018
Toxicol Lett. 2001 Mar 31;120(1-3):353-8
11323194
Science. 1991 Dec 6;254(5037):1471-7
1962206
Annu Rev Entomol. 2003;48:235-60
12208814
Nat Rev Genet. 2001 Sep;2(9):659-68
11533715
Pest Manag Sci. 2005 Mar;61(3):211-8
15660452
Pest Manag Sci. 2005 Mar;61(3):241-5
15706602
Nat Rev Genet. 2004 Dec;5(12):936-48
15573125
Toxicol Lett. 2003 Apr 11;140-141:145-8
12676460
Org Lett. 2005 Oct 13;7(21):4621-3
16209494
Nat Prod Rep. 2002 Jun;19(3):278-91
12137278
Chem Rev. 2002 Aug;102(8):2751-72
12175267
Chem Soc Rev. 2005 Feb;34(2):164-78
15672180
Nature. 2005 Nov 10;438(7065):178
16281026
Org Biomol Chem. 2004 Nov 7;2(21):3150-4
15505721
Chem Commun (Camb). 2006 Apr 21;(15):1670-2
16583015
Pest Manag Sci. 2002 Jul;58(7):649-62
12146165