Fetal to adult stem cell transition: knocking Sox17 off.
What controls the inherent differences between fetal and adult hematopoietic stem cells (HSCs)? In this issue of Cell, Kim et al. (2007) demonstrate in mice that the endodermal transcription factor Sox17 is required for the maintenance of fetal and neonatal but not adult HSCs.
Jang
Yoon-Young
YY
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. yjang3@jhmi.edu
Sharkis
Saul J
SJ
D053687:Adult Stem Cells / Q000166:cytology* / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D053686:Fetal Stem Cells / Q000166:cytology* / Q000378:metabolism*; D024002:HMGB Proteins / Q000172:deficiency* / Q000235:genetics* / Q000502:physiology; D051379:Mice; D055760:SOXF Transcription Factors; D014157:Transcription Factors / Q000172:deficiency* / Q000235:genetics* / Q000502:physiology
D024002:HMGB Proteins; D055760:SOXF Transcription Factors; C511606:Sox17 protein, mouse; D014157:Transcription Factors