[Study on immunological pathogenesis of 59 patients with multiple sclerosis of different TCM syndrome types].
OBJECTIVE
To explore the immunological pathogenesis of multiple sclerosis (MS) patients of different TCM syndrome types.


METHODS
Fifty-nine MS patients were assigned to two types by syndrome typing according to their clinical manifestations, the Gan-Shen yin-deficiency (GSYD, 40 cases) type and the both yin-yang deficiency (YYD, 19 cases) type. Difference of patients' age of first attack, times of relapsing, duration of disease, MRI finding and evoked potential between the two groups were compared. The immunology indexes were also compared in part of the patients (26 cases in GSYD type and 12 cases in YYD type).


RESULTS
The age of first attack was later (P < 0.01), level of myelin basic protein in cerebrospinal fluid was higher (P < 0.05), in the YYD type than those in the GSYD type. Besides, the relapsing time in GSYD type, and the blood-brain barrier index and level of myelin basic protein in YYD type showed an ascending trend (P = 0.056, 0.074, 0.093, respectively).


CONCLUSIONS
Immunological difference exists between the MS patients of GSYD type and those of YYD type.
Zhou
Li
L
Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing.
Fan
Yong-ping
YP
Ye
Ming
M
D000293:Adolescent; D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins / Q000134:cerebrospinal fluid / Q000276:immunology; D008517:Phytotherapy; D013577:Syndrome; D014157:Transcription Factors / Q000134:cerebrospinal fluid / Q000276:immunology; D016711:Yang Deficiency / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D016710:Yin Deficiency / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D055815:Young Adult
D004365:Drugs, Chinese Herbal; C499048:MBP protein, human; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins; D014157:Transcription Factors