Unusual presentation of central nervous system manifestations of Varicella zoster virus vasculopathy in renal transplant recipients.
We describe 2 renal transplant recipients with severe but reversible neurological manifestations related to Varicella zoster virus (VZV) cerebral vasculopathy. To the best of our knowledge, this is the first description of cerebral VZV vasculopathy in solid organ transplant recipients. We review the published literature on the clinical presentation, diagnosis and treatment. In solid organ transplant recipients presenting with neurological signs and symptoms, a diagnosis of VZV-associated vasculopathy should be considered.
Hovens
M M C
MM
Department of General Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands. m.m.c.hovens@lumc.nl
Vaessen
N
N
Sijpkens
Y W J
YW
de Fijter
J W
JW
D000328:Adult; D002494:Central Nervous System Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D005260:Female; D006562:Herpes Zoster / Q000276:immunology / Q000473:pathology*; D014645:Herpesvirus 3, Human / Q000254:growth & development*; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation / Q000276:immunology*; D008875:Middle Aged; D014652:Vascular Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology*