High concordance between self-reported medication and official prescription database information.
OBJECTIVE
We set out to compare the agreement between self-reported psychotropic medication use and information obtained from the administrative prescription database of the Social Insurance Institution of Finland. We compared the point prevalence of psychotropic medication use, and self-reported vs. register-based information on antipsychotic medication dosage.


METHODS
The study population consisted of 905 participants from a population-based genetic study of schizophrenia, of whom 366 had schizophrenia spectrum disorder, 56 had bipolar spectrum disorder, and 483 were unaffected family members. Current medication use was obtained by interview and from the prescription reimbursement database. Agreement between data sources was compared using Cohen's kappa statistic and correlation coefficients.


RESULTS
The agreement between the two sources was generally good. Kappa values were best for lithium use (0.96; p < 0.0001), followed by antipsychotics (0.87; p < 0.0001) and antidepressants (0.77; p < 0.0001). Agreement was lowest for benzodiazepines (0.42; p < 0.0001). Correlation between antipsychotic medication dose estimates was 0.79 (95% CI 0.76-0.81).


CONCLUSIONS
The concordance between self-reported psychotropic medication use and information obtained from an official prescription database was good for most psychotropic drugs. More studies are needed to replicate results with other forms of medication and patient groups.
Haukka
Jari
J
Department for Mental Health and Alcohol Research, Mannerheimintie 166, 00300, Helsinki, Finland. jari.haukka@ktl.fi
Suvisaari
Jaana
J
Tuulio-Henriksson
Annamari
A
Lönnqvist
Jouko
J
D000928:Antidepressive Agents / Q000008:administration & dosage; D014150:Antipsychotic Agents / Q000008:administration & dosage; D003625:Data Collection; D016208:Databases, Factual; D005190:Family; D005387:Finland; D006801:Humans; D018020:Lithium Compounds / Q000008:administration & dosage; D017891:Pharmacoepidemiology / Q000379:methods*; D015995:Prevalence; D011619:Psychotropic Drugs / Q000008:administration & dosage*; D012042:Registries; D012559:Schizophrenia / Q000188:drug therapy*; D012650:Self Disclosure
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D018020:Lithium Compounds; D011619:Psychotropic Drugs
Schizophr Res. 2004 Dec 1;71(2-3):195-212
15474892
Acta Obstet Gynecol Scand. 2004 May;83(5):476-81
15059162
Schizophr Bull. 1998;24(1):1-10
9502542
Basic Clin Pharmacol Toxicol. 2006 Mar;98(3):311-3
16611207
J Clin Epidemiol. 2001 Nov;54(11):1181-6
11675171
BMJ. 2006 Jul 29;333(7561):224
16825203
BMJ. 2007 Feb 3;334(7587):242
17164297
Med Arh. 1999;53(3 Suppl 3):57-60
10870628
Am J Med Genet. 1997 Jul 25;74(4):353-60
9259368
Basic Clin Pharmacol Toxicol. 2006 Mar;98(3):260-5
16611200
Arch Gen Psychiatry. 2006 Dec;63(12):1358-67
17146010
Eur J Hum Genet. 2000 Aug;8(8):604-12
10951523
Arch Gen Psychiatry. 2001 Dec;58(12):1161-7
11735845