A vaccine against Helicobacter pylori: towards understanding the mechanism of protection.
Helicobacter pylori infection remains a significant global public health problem. Vaccine development against this infection appears to be feasible but has not yet delivered its promise in clinical trials. Efforts to improve current vaccination strategies would greatly benefit from a better molecular understanding of the mechanism of protection. Here, we review recent developments in this field.
Aebischer
Toni
T
Department of Molecular Biology, Max Planck Institute for Infection Biology, Charité Platz 1, D-10117 Berlin, Germany.
Walduck
Anna
A
Schroeder
Juliane
J
Wehrens
Andrea
A
Chijioke
Obinna
O
Schreiber
Soeren
S
Meyer
Thomas F
TF
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000276:immunology / Q000382:microbiology; D005767:Gastrointestinal Diseases / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D016481:Helicobacter Infections / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D016480:Helicobacter pylori / Q000276:immunology*; D051379:Mice
D001428:Bacterial Vaccines