[Association between serum adiponectin and mean blood pressure].
OBJECTIVE
To investigate the relationship between serum adiponectin and mean blood pressure (BP).


METHODS
A total of 187 subjects were divided into four groups according to BP levels: optimal blood pressure group (n = 38), high normal blood pressure group (n = 50), treated hypertension group (n = 54) and untreated hypertension group (n = 45). Serum adiponectin and microalbuminuria were detected by radioimmunology assay. Insulin resistant index defined as HOMA-IR and urinary concentration of microalbuminuria/urinary concentration of creatinine defined as albumin creatinine ratio (ACR) were calculated.


RESULTS
(1) Serum adiponectin decreased in proportion to BP increase and the serum adiponectin level was significantly higher in treated hypertension group than untreated hypertension group. (2) Correlation analysis showed that adiponectin concentration was negatively correlated with mean blood pressure (P < 0.01). (3) Multivariate regression analysis revealed that mean blood pressure and HOMA-IR were independent predictors of serum adiponectin level.


CONCLUSIONS
Mean blood pressure was the main determinant of serum adiponectin level and negatively correlated to serum adiponectin level.
Li
Xin-Li
XL
Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. xinli3267@yeah.net
Tong
Min
M
Xu
Qiong
Q
Lu
Xin-Zheng
XZ
Wang
Zhen-Zhen
ZZ
Zhou
Yan-Li
YL
Zhang
Hai-Feng
HF
Cao
Ke-Jiang
KJ
Huang
Jun
J
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010808:Physical Examination / Q000706:statistics & numerical data
D052242:Adiponectin