Imaging optically scattering objects with ultrasound-modulated optical tomography.
We show the feasibility of imaging objects having different optical scattering coefficients relative to the surrounding scattering medium using ultrasound-modulated optical tomography (UOT). While the spatial resolution depends on ultrasound parameters, the image contrast depends on the difference in scattering coefficient between the object and the surrounding medium. Experimental measurements obtained with a CCD-based speckle contrast detection scheme are in agreement with Monte Carlo simulations and analytical calculations. This study complements previous UOT experiments that demonstrated optical absorption contrast.
Kothapalli
Sri-Rajasekhar
SR
Department of Biomedical Engineering, Optical Imaging Laboratory, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130-4899, USA.
Sakadzić
Sava
S
Kim
Chulhong
C
Wang
Lihong V
LV
D019047:Phantoms, Imaging; D012542:Scattering, Radiation; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*; D014465:Ultrasonics