title: Rapid development of an osteosarcoma after surgical resection of an osteochondroma.
abstract: The rapid development of an osteosarcoma, after surgical resection of an osteochondroma, has not been yet reported. We present here the case of a 12-year-old girl that had, in less than 2 months, an osteosarcoma at the initial site of a treated osteochondroma. Comparative Genomic Hybridization analyses showed that the 2 tumors were genetically distinct, suggesting a distant, if any, relationship. The possible implication of a deregulated tissue homeostasis caused by the surgical intervention is discussed. Proangiogenic factors involved in the tissue healing could be the triggering factor favoring tumor angiogenesis and explaining the very rapid progression of the tumor.
authors: Centre Hospitalier Universitaire, Hôpital des Enfants, Toulouse 3, France.
authors: Anne
authors: A
authors: Gomez-Brouchet
authors: Franck
authors: F
authors: Accadbled
authors: Herve
authors: H
authors: Rubie
authors: Dora
authors: D
authors: Janka
authors: Marie-Pierre
authors: MP
authors: Castex
authors: Benedicte
authors: B
authors: Thuille
authors: Olivier
authors: O
authors: Delattre
authors: Henrick
authors: H
authors: Laurell
authors: Christiane
authors: C
authors: Baunin
authors: Jérôme Sales
authors: JS
authors: de Gauzy
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology*; D002648:Child; D018450:Disease Progression; D005260:Female; D015894:Genome, Human; D006801:Humans; D009389:Neovascularization, Pathologic; D009693:Nucleic Acid Hybridization; D015831:Osteochondroma / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography