Interleukin-12 and tuberculosis: an old story revisited.
Our understanding of the role of interleukin (IL)-12 in controlling tuberculosis has expanded because of increased interest in other members of the IL-12 family of cytokines. Recent data show that IL-12, IL-23 and IL-27 have specific roles in the initiation, expansion and control of the cellular response to tuberculosis. Specifically, IL-12, and to a lesser degree IL-23, generates protective cellular responses and promotes survival, whereas IL-27 moderates the inflammatory response and is required for long-term survival. Paradoxically, IL-27 also limits bacterial control, suggesting that a balance between bacterial killing and tissue damage is required for survival. Understanding the balance between IL-12, IL-23 and IL-27 is crucial to the development of immune intervention in tuberculosis.
Cooper
Andrea M
AM
The Trudeau Institute, Inc. 154 Algonquin Ave. Saranac Lake, NY 12983, USA. acooper@trudeauinstitute.org
Solache
Alejandra
A
Khader
Shabaana A
SA
D000818:Animals; D002908:Chronic Disease; D006801:Humans; D007111:Immunity, Cellular; D018664:Interleukin-12 / Q000276:immunology / Q000378:metabolism*; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism*; D053759:Interleukin-23 / Q000276:immunology / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology
D020381:Interleukin-17; D053759:Interleukin-23; D018664:Interleukin-12
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