[Adult stem cells and stem cell disease].
OBJECTIVE
To summarize the characteristics of adult stem cells and to introduce the definition and the features of stem cell disease.


METHODS
Literature concerning adult stem cells and stem cell disease was extensively reviewed.


RESULTS
Adult stem cells were localized in tissues and organs, and were able to generate function cells to replace cell loss during a lifetime of wear and tear. The stem cells had self-renewal to maintain themselves and undergo aging within the lifespan of an organism. The dysfunction of stem cells was capable to cause diseases, which could be defined as stem cell disease in human. The disorder of self renewal and differentiation in stem cells could increase the cellular proliferation, produce proliferative diseases such as tumors. The stem cells with self renewal defect, differentiation blockage, or aged stem cells could not supply enough function cells for tissue refreshment. The defect of tissue refreshment caused degenerative diseases.


CONCLUSIONS
Studies on the stem cell self renew, differentiation, and aging can provide knowledge to understand the mechanism of stem cell diseases and develop technique to diagnose and treat these diseases.
Mo
Xianming
X
Department of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, PR China. xmingmo@yahoo.com
D053687:Adult Stem Cells / Q000166:cytology*; D000544:Alzheimer Disease / Q000473:pathology*; D001161:Arteriosclerosis / Q000473:pathology; D002454:Cell Differentiation; D049109:Cell Proliferation; D053686:Fetal Stem Cells / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D015398:Signal Transduction