Lupus erythematosus tumidus induced by sex reassignment surgery.
We describe a case of sex reassignment surgery and the subsequent development of lupus erythematosus tumidus (LET). LET is characterized clinically by erythematous, succulent, edematous, nonscarring plaques in sun-exposed areas. Results of histological examination show perivascular and periadnexal lymphocytic infiltration and interstitial mucin deposition. This report emphasizes that environmental triggers, including prolonged exposure to significant doses of estrogens as part of sex reassignment surgery, may lead to the development of lupus in a nonpredisposed individual.
Zandman-Goddard
Gisele
G
Department of Medicine C, Wolfson Medical Center, Holon, Israel. goddard@wolfson.health.gov.il
Solomon
Michal
M
Barzilai
Aviv
A
Shoenfeld
Yehuda
Y
D004967:Estrogens / Q000009:adverse effects*; D005260:Female; D005783:Gender Identity; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D012727:Sex Characteristics; D014189:Transsexualism / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D014466:Ultraviolet Rays / Q000009:adverse effects
D004967:Estrogens