In vivo biological evaluation of high molecular weight hyperbranched polyglycerols.
Hyperbranched polyglycerols (HPGs) are water-soluble polyether polyols that can be synthesized in a controlled manner with low polydispersity. Recently we reported the synthesis and characterization of very high molecular weight and narrowly polydispersed HPGs that could be used as potential alternatives to high generation dendrimers, their advantage being the relative simplicity of synthesis. Reported in this article are the pharmacokinetic properties of these polymers. Two polymers of number average molecular weights 106,000 and 540,000 were tested in mice for their pharmacokinetic behavior. The plasma half-life for the lower molecular weight polymer was around 32 h whereas that of the higher molecular weight HPG was approximately 57 h. Our results show that these high molecular weight HPGs, which can be prepared in a single step reaction, are potential candidates for drug delivery and imaging applications where a long circulating polymer is highly desirable. A detailed tissue distribution profile of these polymers as a function of molecular weight is described. These polymers were also found to be hydrolytically stable and the concentration dependence of solution viscosity measurements suggested the absence of any aggregation.
Kainthan
Rajesh K
RK
Department of Pathology and Laboratory Medicine, Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada V6T 2B5.
Brooks
Donald E
DE
D000818:Animals; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics*; D005260:Female; D005990:Glycerol / Q000737:chemistry* / Q000493:pharmacokinetics*; D006207:Half-Life; D008422:Materials Testing; D008657:Metabolic Clearance Rate; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D009928:Organ Specificity; D011108:Polymers / Q000737:chemistry* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D004337:Drug Carriers; D011108:Polymers; C043941:polyglycerol; D005990:Glycerol