title: Glutathione status in the blood and tissues of patients with virus-originated hepatocellular carcinoma.
abstract: OBJECTIVE
  Glutathione status can be regarded as the redox status for many diseases. This study was performed to investigate the glutathione status in virus-originated hepatocellular carcinoma (HCC).
  
  
  METHODS
  The blood and tissue samples were obtained from 24 patients. Blood samples were also obtained from 137 controls for comparison.
  
  
  RESULTS
  The GSH level and the ratios of GSH/GSSG and GSH/total glutathione of the blood samples from the patients were significantly lower than those of the controls, while the GSSG values were significantly higher. Meanwhile, levels of GSH and total glutathione, as well as the ratios of GSH/GSSH and GSH/total glutathione, were significantly decreased, whereas GSSG levels were significantly higher, in the HCC tissues than those of the adjacent cancer-free tissues.
  
  
  CONCLUSIONS
  Glutathione status in the HCC suggested that the antioxidant system is severely impaired, supporting a consistent role of the free radical cytotoxicity in the pathophysiology of the disease.
authors: Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors: King-Teh
authors: KT
authors: Lee
authors: Shih-Meng
authors: SM
authors: Tsai
authors: Shen-Nien
authors: SN
authors: Wang
authors: Shu-Kai
authors: SK
authors: Lin
authors: Szu-Hwa
authors: SH
authors: Wu
authors: Shih-Chung
authors: SC
authors: Chuang
authors: Szu-Hsien
authors: SH
authors: Wu
authors: Hsu
authors: H
authors: Ma
authors: Li-Yu
authors: LY
authors: Tsai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000209:etiology / Q000473:pathology / Q000821:virology; D016022:Case-Control Studies; D005260:Female; D005978:Glutathione / Q000097:blood* / Q000378:metabolism*; D019803:Glutathione Disulfide / Q000032:analysis / Q000097:blood; D006518:Hepatitis Viruses; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000209:etiology / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged
chemical_list: D005978:Glutathione; D019803:Glutathione Disulfide