Conserved lipid-binding sites in membrane proteins: a focus on cytochrome c oxidase.
Specific interactions between lipids and membrane proteins have been observed in recent high-resolution crystal structures of membrane proteins. A number of cytochrome oxidase structures were analyzed, along with many amino acid sequences of membrane-spanning regions aligned according to their location in the membrane. The results reveal conservation of lipid-binding sites and of the residues that form them. These studies imply that bound lipids have important roles that are crucial to the assembly, structure, or activity of the protein. Evidence for some of these roles in subunit interactions, membrane insertion, and protein-protein complex formation is reviewed.
Qin
Ling
L
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824-1319, USA.
Sharpe
Martyn A
MA
Garavito
R Michael
RM
Ferguson-Miller
Shelagh
S
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D017124:Conserved Sequence; D003576:Electron Transport Complex IV / Q000737:chemistry* / Q000378:metabolism; D019143:Evolution, Molecular; D006801:Humans; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data
D008563:Membrane Lipids; D008565:Membrane Proteins; D003576:Electron Transport Complex IV
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