Common cues regulate neural and vascular patterning.
Nerves and blood vessels often follow parallel trajectories as they course through the body to their distal targets. Proteins that regulate the process of axon guidance have likewise been shown to play a crucial role in blood vessel migration. With the recent description of the endothelial tip cell as an analog of the axonal growth cone, the nerve-vessel analogy seems complete. Notwithstanding these considerable similarities, one crucial difference remains between neural and vascular guidance. While a navigating axon is but a single cell, a sprouting vessel is composed of multiple cells that must be co-ordinately regulated. Recent studies of the Dll4-Notch1 signaling pathway have provided valuable insight into how the vasculature accomplishes this crucial task.
Jones
Christopher A
CA
Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, United States.
Li
Dean Y
DY
D000818:Animals; D001808:Blood Vessels / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D009417:Nerve Tissue / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D051881:Receptor, Notch1 / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051881:Receptor, Notch1; C064045:delta protein
Science. 1999 Oct 22;286(5440):741-6
10531053
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3225-30
17296941
Nat Neurosci. 2000 Jan;3(1):30-40
10607392
Curr Biol. 1999 Dec 16-30;9(24):1448-57
10607588
Curr Opin Neurobiol. 2000 Feb;10(1):88-94
10679438
Genes Dev. 2000 Jun 1;14(11):1343-52
10837027
Nat Rev Neurosci. 2001 Mar;2(3):155-64
11256076
Bioessays. 2001 Jun;23(6):494-507
11385629
Neuron. 2001 Nov 20;32(4):605-17
11719202
Genomics. 2002 Apr;79(4):547-52
11944987
Dev Cell. 2002 Jul;3(1):127-36
12110173
Genes Dev. 2002 Oct 15;16(20):2684-98
12381667
Development. 2003 Jan;130(2):411-23
12466207
Science. 2002 Dec 6;298(5600):1959-64
12471249
J Anat. 2003 Jan;202(1):105-12
12587925
Nat Med. 2003 Jun;9(6):685-93
12778167
Development. 2003 Jul;130(14):3227-36
12783793
J Cell Biol. 2003 Jun 23;161(6):1163-77
12810700
Nature. 2003 Jul 24;424(6947):391-7
12879061
Dev Biol. 2003 Sep 1;261(1):251-67
12941633
Dev Cell. 2004 Jul;7(1):107-16
15239958
Dev Cell. 2004 Jul;7(1):117-23
15239959
Genes Dev. 2004 Oct 15;18(20):2469-73
15466160
Neuron. 1990 Jan;4(1):61-85
2310575
Cell. 1995 Aug 11;82(3):359-70
7634326
Cell. 1995 Aug 11;82(3):371-81
7634327
Nature. 1996 Apr 4;380(6573):435-9
8602241
Nature. 1996 Apr 4;380(6573):439-42
8602242
Cell. 1996 Dec 27;87(7):1171-80
8980224
Science. 1997 Jul 4;277(5322):55-60
9204896
Nature. 1998 May 21;393(6682):276-80
9607766
Curr Opin Cell Biol. 1998 Oct;10(5):609-13
9818171
Cell. 1999 Jun 25;97(7):927-41
10399920
Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15949-54
15520367
Nature. 2004 Nov 11;432(7014):179-86
15510105
Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16210-5
15520390
FASEB J. 2005 Jan;19(1):121-3
15486058
Science. 2005 Jan 14;307(5707):265-8
15550623
Circulation. 2005 Apr 12;111(14):1826-32
15809373
Biochem Biophys Res Commun. 2005 Jul 1;332(2):533-41
15894287
J Biol Chem. 2006 Apr 21;281(16):11347-56
16481322
Biochem Soc Trans. 2006 Jun;34(Pt 3):418-21
16709176
Science. 2006 Aug 4;313(5787):640-4
16809490
Sci STKE. 2006 Dec 5;2006(364):cm7
17148788
Development. 2007 Mar;134(5):839-44
17251261
Nature. 2007 Feb 15;445(7129):781-4
17259972
Nature. 2007 Feb 15;445(7129):776-80
17259973
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3219-24
17296940
Development. 2000 Jan;127(2):269-78
10603345