Alcohol metabolism's damaging effects on the cell: a focus on reactive oxygen generation by the enzyme cytochrome P450 2E1.
Alcohol metabolism's various processes create harmful compounds that contribute to cell and tissue damage. In particular, the enzyme cytochrome P450 2E1 (CYP2E1) plays a role in creating a harmful condition known as oxidative stress. This condition is related to oxygen's ability to accept electrons and the subsequent highly reactive and harmful byproducts created by these chemical reactions. CYP2E1's use of oxygen in alcohol metabolism generates reactive oxygen species, ultimately leading to oxidative stress and tissue damage.
Koop
Dennis R
DR
Department ofPhysiology and Pharmacology at Oregon Health and Science University Portland, Oregon, USA.
D002477:Cells / Q000187:drug effects; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism*; D000431:Ethanol / Q000009:adverse effects / Q000378:metabolism*; D006801:Humans; D008108:Liver Diseases, Alcoholic; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D013481:Superoxides
D017382:Reactive Oxygen Species; D013481:Superoxides; D000431:Ethanol; D019392:Cytochrome P-450 CYP2E1
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