Chromosomal instability in cancer: causality and interdependence.
Aberrations in the number and structure of chromosomes are a common feature of cells from solid tumours. In this brief review, I summarize the evidence that there is a causal relationship between chromosomal instability and the initiation or progression of cancer, and argue that the co-existence of both forms of instability in many solid tumours reflects mechanistic and functional interdependencies that remain poorly investigated.
Venkitaraman
Ashok R
AR
University of Cambridge, Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge CB2 0XZ, UK. arv22@hutchison-mrc.cam.ac.uk
D000818:Animals; D043171:Chromosomal Instability; D025063:Chromosome Disorders / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes