Analytic view to concordance between electrocochleography and caloric test in Meniere's disease.
We aimed to investigate if there is a concordance between summation potential (SP)/action potential (AP) ratio and unilateral weakness in patients with definite-Meniere's disease. There were two groups, a group of unilateral definite-Meniere patients who received no treatment and another group of control subjects. Twenty-six patients were identified as complying with the defined criteria. Fifteen healthy subjects with no hearing and balance disorders were assigned to the control group. Arithmetic mean of the four-tone average of thresholds at 0.5, 1, 2, and 3 or 4 kHz, SP/AP ratio and degree of unilateral weakness were calculated. The number of patients was tabulated based on the presence of abnormal SP/AP ratio and unilateral weakness. Co-occurrence of unilateral weakness and elevated-SP/AP ratio was investigated with reference to the stage of the disease. A correlation was sought among pure-tone average, SP/AP ratio and degree of unilateral weakness in a pair-wise manner. Unilateral weakness and abnormal SP/AP ratio were identified in 53.8% and 38.4% of the patients, respectively. Co-occurrence of unilateral weakness and abnormal SP/AP ratio was observed in 34.6% of the patients. However, it was noticed that this co-occurrence gradually increased when the disease progressed. Mean SP/AP ratio also gradually increased as the stage progressed. Of pair-wise correlations among pure-tone average, SP/AP ratio and degree of unilateral weakness, a weak correlation (r = 0.383) was found only between SP/AP ratio and degree of unilateral weakness with marginal significance (P = 0.053). We concluded that co-occurrence of unilateral weakness and elevated SP/AP ratio increases when the disease progresses. This co-occurrence is less encountered in earlier stages. This difference might be resulted from a difference in distension capability of the endolymphatic space of the cochlea and the vestibule. Albeit weak, there was a correlation between mean SP/AP ratio and degree of unilateral weakness, which suggests that the disease parallelly disturbs the lateral semicircular or cochlear functions especially in advanced stages.
Satar
Bulent
B
Department of ORL Head&Neck Surgery, Gülhane Military Medical School, Ankara, Turkey. bulentsatar@yahoo.com
Karahatay
Serdar
S
Sen
Deniz
D
Cekin
Engin
E
Birkent
Hakan
H
D000328:Adult; D001300:Audiometry, Evoked Response; D001301:Audiometry, Pure-Tone; D002150:Caloric Tests; D003051:Cochlea / Q000503:physiopathology; D004584:Electronystagmography; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis* / Q000503:physiopathology; D012720:Severity of Illness Index; D014717:Vertigo / Q000175:diagnosis / Q000503:physiopathology
ORL J Otorhinolaryngol Relat Spec. 1990;52(5):281-5
2234898
Laryngoscope. 1982 Dec;92(12):1383-9
7176790
Acta Otolaryngol Suppl. 1991;485:78-83
1843175
Acta Otolaryngol. 2003 Apr;123(3):388-95
12737296
Acta Otolaryngol. 1969 Jan;67(1):57-68
5373617
Am J Otolaryngol. 2005 Mar-Apr;26(2):128-31
15742267
Am J Otol. 2000 Jan;21(1):81-7
10651439
Otolaryngol Head Neck Surg. 1995 Sep;113(3):181-5
7675476
Acta Otolaryngol. 2000 Jun;120(4):480-3
10958398
Acta Otolaryngol. 2002 Mar;122(2):173-8
11936909
Am J Otol. 1993 May;14(3):290-4
8372928
Laryngoscope. 1998 Jul;108(7):993-1000
9665245
Otol Neurotol. 2004 Mar;25(2):144-9
15021774
Otolaryngol Clin North Am. 1980 Nov;13(4):631-42
7454325
Acta Otolaryngol. 1979;88(5-6):420-3
316964
J Otolaryngol. 2002 Dec;31(6):371-5
12593550
Arch Otolaryngol. 1981 May;107(5):263-70
7224944
Arch Otolaryngol. 1985 Feb;111(2):71-4
3977730
Am J Otol. 2000 Jul;21(4):552-8
10912702
Otol Neurotol. 2002 Sep;23(5):799-805
12218638
Clin Otolaryngol Allied Sci. 1994 Feb;19(1):73-8
8174307
Acta Otolaryngol. 1998 Mar;118(2):150-6
9583780
Clin Otolaryngol Allied Sci. 2001 Jun;26(3):257-60
11437853
Acta Otolaryngol. 1982 Jul-Aug;94(1-2):19-27
7124387
Laryngoscope. 1986 Nov;96(11):1258-71
3773627