title: Vertical transmission and fetal replication of Nipah virus in an experimentally infected cat.
abstract: A female adult cat developed clinical disease 13 days after subcutaneous inoculation with Nipah virus (NiV) and was discovered to be pregnant at necropsy. Viral genome was detected in a variety of specimens, including blood, serum, tonsil swabs, and urine, up to 3 days before the onset of disease. Samples collected postmortem, including placenta, uterine fluid, and fetal tissues, were also positive for NiV genome, and the placenta and uterine fluid contained high levels of recoverable virus. The high levels of viral shedding in the adult combined with fetal viral replication suggests that both vertical and horizontal transmission of NiV could play a role in spillover events, an essential element in the epidemiology of Henipavirus infection.
authors: Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
authors: Bruce A
authors: BA
authors: Mungall
authors: Deborah
authors: D
authors: Middleton
authors: Gary
authors: G
authors: Crameri
authors: Kim
authors: K
authors: Halpin
authors: John
authors: J
authors: Bingham
authors: Bryan T
authors: BT
authors: Eaton
authors: Christopher C
authors: CC
authors: Broder
mesh_terms: D000818:Animals; D002415:Cats; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005333:Fetus / Q000821:virology; D045464:Henipavirus Infections / Q000635:transmission*; D018445:Infectious Disease Transmission, Vertical; D045405:Nipah Virus / Q000302:isolation & purification*; D014066:Palatine Tonsil / Q000821:virology; D010920:Placenta / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D044967:Serum / Q000821:virology; D014556:Urine / Q000821:virology; D014599:Uterus / Q000821:virology; D017201:Virus Shedding
chemical_list: D004279:DNA, Viral