title: Retinopathy of prematurity in Asian Indian babies weighing greater than 1250 grams at birth: ten year data from a tertiary care center in a developing country.
abstract: BACKGROUND
  Retinopathy of prematurity (ROP) is an important cause of childhood blindness in developing countries.
  
  
  OBJECTIVE
  To report the spectrum of ROP and associated risk factors in babies weighing > 1250 g at birth in a developing country.
  
  
  METHODS
  Institutional, retrospective, non-randomized, observational clinical case series.
  
  
  METHODS
  Retrospective analysis (10 years) of 275 eyes (138 babies) with ROP.
  
  
  METHODS
  Qualitative data with the Chi-square test. Quantitative data using the unpaired t test or the ANOVA and further tested using multivariate logistic regression.
  
  
  RESULTS
  The mean birth weight was 1533.9 g (range 1251 to 2750 g) and the mean period of gestation was 30.9 weeks (range 26 to 35). One hundred and twenty-four of 275 eyes (45.1%) had threshold or worse ROP. Risk factors for threshold or worse disease were, 'outborn babies' ( P P = 0.007) and exchange transfusion ( P = 0.003). The sensitivity of the American and British screening guidelines to pick up threshold or worse ROP in our study group was 82.4% and 77.4% respectively.
  
  
  CONCLUSIONS
  Severe ROP is often encountered in babies weighing greater than 1250 g at birth in developing countries. Western screening guidelines may require modifications before application in developing countries.
authors: Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors: Anand
authors: A
authors: Vinekar
authors: Mangat R
authors: MR
authors: Dogra
authors: Tiakumzuk
authors: T
authors: Sangtam
authors: Anil
authors: A
authors: Narang
authors: Amod
authors: A
authors: Gupta
mesh_terms: D044466:Asian People; D005500:Follow-Up Studies; D006764:Hospitals, Community / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D015999:Multivariate Analysis; D012178:Retinopathy of Prematurity / Q000208:ethnology*; D012189:Retrospective Studies; D012307:Risk Factors
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