Salivary gland scintigraphy in gastro-esophageal reflux disease.
Gastro-esophageal reflux disease (GERD) is associated with a decreased salivary flow as well as gastric acid production. This study therefore aimed to investigate functional disorders of salivary glands in patients with GERD.


METHODS
Thirty-one consecutive patients with GERD underwent salivary gland scintigraphy.


RESULTS
If the results defined the optimal cutoff point for determining the decreased salivary secretion as 51 % in parotid glands and 36 % in submandibular glands, a decreased salivary secretion of right parotid gland, left parotid gland, right submandibular gland, and left submandibular gland was found in 39 %, 32 %, 36 %, and 58 %, respectively. Overall, salivary function disorder of at least one major salivary gland was found in 24 patients (78 %) with GERD. There was no difference in the incidence of impaired salivary function between GERD patients with and without erosive esophagitis. Salivary gland function was more frequently diminished than expected in GERD. We concluded that the presence of impaired salivary gland function was considered to be one of risk factors for developing GERD symptoms.
Urita
Y
Y
Department of General Medicine and Emergency Care, Toho University School of Medicine, 6-11-1, Omori-Nishi, Ota-Ku, Tokyo 143-8541, Japan. foo@eb.mbn.or.jp
Domon
K
K
Yanagisawa
T
T
Ishihara
S
S
Hoshina
M
M
Akimoto
T
T
Kato
H
H
Hara
N
N
Honda
Y
Y
Nagai
Y
Y
Nakanishi
K
K
Shimada
N
N
Takano
M
M
Watanabe
T
T
Sugimoto
M
M
Miki
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012307:Risk Factors; D012466:Salivary Gland Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism*; D012469:Salivary Glands / Q000000981:diagnostic imaging* / Q000378:metabolism; D013670:Sodium Pertechnetate Tc 99m; D013363:Submandibular Gland / Q000000981:diagnostic imaging / Q000378:metabolism
D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m