title: Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence.
abstract: The predictive value of acute gut-associated lymphoid tissue (GALT) CD4+ T cell depletion in lentiviral infections was assessed by comparing three animal models illustrative of the outcomes of SIV infection: pathogenic infection (SIVsmm infection of rhesus macaques (Rh)), persistent nonprogressive infection (SIVagm infection of African green monkeys (AGM)), and transient, controlled infection (SIVagm infection of Rh). Massive acute depletion of GALT CD4+ T cells was a common feature of acute SIV infection in all three models. The outcome of this mucosal CD4+ T cell depletion, however, differed substantially between the three models: in SIVsmm-infected Rh, the acute GALT CD4+ T cell depletion was persistent and continued with disease progression; in SIVagm, intestinal CD4+ T cells were partially restored during chronic infection in the context of normal levels of apoptosis and immune activation and absence of damage to the mucosal immunologic barrier; in SIVagm-infected Rh, complete control of viral replication resulted in restoration of the mucosal barrier and immune restoration. Therefore, our data support a revised paradigm wherein severe GALT CD4+ T cell depletion during acute pathogenic HIV and SIV infections of humans and Rh is necessary but neither sufficient nor predictive of disease progression, with levels of immune activation, proliferation and apoptosis being key factors involved in determining progression to AIDS.
authors: Divisions of Comparative Pathology and Microbiology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA. ipandrea@tulane.edu
authors: Ivona V
authors: IV
authors: Pandrea
authors: Rajeev
authors: R
authors: Gautam
authors: Ruy M
authors: RM
authors: Ribeiro
authors: Jason M
authors: JM
authors: Brenchley
authors: Isolde F
authors: IF
authors: Butler
authors: Melissa
authors: M
authors: Pattison
authors: Terri
authors: T
authors: Rasmussen
authors: Preston A
authors: PA
authors: Marx
authors: Guido
authors: G
authors: Silvestri
authors: Andrew A
authors: AA
authors: Lackner
authors: Alan S
authors: AS
authors: Perelson
authors: Daniel C
authors: DC
authors: Douek
authors: Ronald S
authors: RS
authors: Veazey
authors: Cristian
authors: C
authors: Apetrei
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002522:Chlorocebus aethiops; D007108:Immune Tolerance; D007413:Intestinal Mucosa / Q000276:immunology; D007422:Intestines / Q000276:immunology*; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity*; D014774:Virulence; D014779:Virus Replication
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