Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba.
The neurosedative and antioxidative properties of some major compounds isolated from a citral chemotype of Lippia alba were investigated. Binding assays were performed on two CNS inhibitory targets: benzodiazepine and GABA(A) receptors. The most active compound was luteolin-7-diglucuronide, with half maximal inhibitory concentrations (IC(50)) of 101 and 40 microm, respectively. Fifteen compounds isolated from Lippia alba were tested for their radical scavenging capacities against DPPH. Four of the major compounds (verbascoside, calceolarioside E, luteolin-7-diglucuronide and theveside) were also tested for their antioxidant activity against superoxide radical-anion in cell-free (hypoxanthine-xanthine oxidase) and cellular (PMA-stimulated neutrophil granulocytes) systems.
Hennebelle
Thierry
T
Laboratoire de Pharmacognosie, EA 1043, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille 2, Lille, France.
Sahpaz
Sevser
S
Gressier
Bernard
B
Joseph
Henry
H
Bailleul
François
F
D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D001713:Biphenyl Compounds / Q000737:chemistry; D005260:Female; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D006834:Hydrazines / Q000737:chemistry; D006993:Hypnotics and Sedatives / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D039823:Iridoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D032411:Lippia / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D059808:Polyphenols; D017382:Reactive Oxygen Species / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism
D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D016166:Free Radical Scavengers; D006834:Hydrazines; D006993:Hypnotics and Sedatives; D039823:Iridoids; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D059808:Polyphenols; D017382:Reactive Oxygen Species; D011963:Receptors, GABA-A; C004931:1,1-diphenyl-2-picrylhydrazyl