title: Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors.
authors.affiliation: Genomics Research Center, Academia Sinica, No. 128, Sec. 2, Academia Rd., Taipei City 115, Taiwan, ROC.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shao
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Yang
authors.forename: Hung-Pin
authors.initials: HP
authors.lastname: Peng
authors.forename: Min-Feng
authors.initials: MF
authors.lastname: Hsu
authors.forename: Keng-Chang
authors.initials: KC
authors.lastname: Tsai
authors.forename: Tun-Hsun
authors.initials: TH
authors.lastname: Kuo
authors.forename: Andrew H-J
authors.initials: AH
authors.lastname: Wang
authors.forename: Po-Huang
authors.initials: PH
authors.lastname: Liang
authors.forename: Chun-Hung
authors.initials: CH
authors.lastname: Lin
authors.forename: An-Suei
authors.initials: AS
authors.lastname: Yang
authors.forename: Chi-Huey
authors.initials: CH
authors.lastname: Wong
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D000086782:Coronavirus 3C Proteases; D003460:Crystallization; D018360:Crystallography, X-Ray / Q000379:methods; D003546:Cysteine Endopeptidases; D015195:Drug Design; D006860:Hydrogen Bonding; D008024:Ligands; D008956:Models, Chemical; D008968:Molecular Conformation; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011487:Protein Conformation; D045473:Severe acute respiratory syndrome-related coronavirus / Q000201:enzymology*; D014764:Viral Proteins / Q000037:antagonists & inhibitors*; D014965:X-Rays
chemical_list: D008024:Ligands; D011480:Protease Inhibitors; D014764:Viral Proteins; D003546:Cysteine Endopeptidases; D000086782:Coronavirus 3C Proteases