title: Correlation between bone lesion changes and cartilage volume loss in patients with osteoarthritis of the knee as assessed by quantitative magnetic resonance imaging over a 24-month period.
abstract: OBJECTIVE
  To evaluate in patients with knee osteoarthritis (OA) the size changes in bone oedema and cysts over 24 months, and to contrast these changes with cartilage volume loss using quantitative magnetic resonance imaging.
  
  
  METHODS
  107 patients with knee OA, selected from a large trial evaluating the effect of a bisphosphonate, were analysed by magnetic resonance imaging at baseline and 24 months. Assessments of subchondral bone oedema and cysts, and cartilage volume were done.
  
  
  RESULTS
  At baseline, 86 patients showed the presence of at least one type of bone lesion: 71 oedema, 61 cysts and 51 both. At 24 months, although not statistically significant, the oedema total size change increased by 2.09 (SD 15.03) mm, and the cyst by 1.09 (8.13) mm; mean size change for the oedema was +0.38 (2.18) mm and -0.10 (4.36) mm for the cyst. When analysed according to subregions, an increase was found for the cyst size in the trochlea (+0.67 (2.74) mm, p = 0.02) and in the lateral tibial plateau (+0.15 (0.83) mm, p = 0.09), and for the oedema size in the medial tibial plateau (+1.73 (8.11) mm, p = 0.05). At 24 months, significant correlations were seen between the loss of cartilage volume and oedema size change in the medial condyle (-0.40, p = 0.0001) and the medial tibial plateau (-0.23, p = 0.03), and the changes in cyst size in the medial condyle (-0.29, p = 0.01). A multivariate analysis showed that the oedema size change was strongly and independently associated with medial cartilage volume loss (-0.31, p = 0.0004).
  
  
  CONCLUSIONS
  These data demonstrate that bone lesions are prevalent in knee OA. The correlation of the oedema and cyst size increase in the medial compartment over time with a greater loss of cartilage volume in this area underlines the importance of subchondral bone lesions in OA pathophysiology.
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Centre (CHUM), Notre-Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada. jp.raynauld@videotron.ca
authors.forename: J-P
authors.initials: JP
authors.lastname: Raynauld
authors.forename: J
authors.initials: J
authors.lastname: Martel-Pelletier
authors.forename: M-J
authors.initials: MJ
authors.lastname: Berthiaume
authors.forename: F
authors.initials: F
authors.lastname: Abram
authors.forename: D
authors.initials: D
authors.lastname: Choquette
authors.forename: B
authors.initials: B
authors.lastname: Haraoui
authors.forename: J F
authors.initials: JF
authors.lastname: Beary
authors.forename: G A
authors.initials: GA
authors.lastname: Cline
authors.forename: J M
authors.initials: JM
authors.lastname: Meyer
authors.forename: J-P
authors.initials: JP
authors.lastname: Pelletier
mesh_terms: D000704:Analysis of Variance; D001845:Bone Cysts / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology*; D002358:Cartilage, Articular / Q000473:pathology*; D004164:Diphosphonates / Q000627:therapeutic use; D018450:Disease Progression; D004487:Edema / Q000473:pathology; D012968:Etidronic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D005269:Femur / Q000473:pathology; D051445:Fibrocartilage / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy / Q000473:pathology*; D010329:Patella / Q000473:pathology; D000068296:Risedronic Acid
chemical_list: D004164:Diphosphonates; D000068296:Risedronic Acid; D012968:Etidronic Acid