title: Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related Zinc-Finger ZIM proteins.
abstract: The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.
authors.affiliation: Intercollege Graduate Degree Program in Genetics, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
authors.forename: Hongliu
authors.initials: H
authors.lastname: Sun
authors.forename: Brian L
authors.initials: BL
authors.lastname: Nelms
authors.forename: Sama F
authors.initials: SF
authors.lastname: Sleiman
authors.forename: Helen M
authors.initials: HM
authors.lastname: Chamberlin
authors.forename: Wendy
authors.initials: W
authors.lastname: Hanna-Rose
mesh_terms: D019943:Amino Acid Substitution; D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000502:physiology; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics; D005786:Gene Expression Regulation; D017238:Genes, Helminth; D014157:Transcription Factors / Q000502:physiology*; D016335:Zinc Fingers
chemical_list: D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; C507738:HIM-8 protein, C elegans; D014157:Transcription Factors; C516318:Zim-1 protein, C elegans; C516319:Zim-2 protein, C elegans; C516320:Zim-3 protein, C elegans