Genetics of nickel allergic contact dermatitis.
Nickel sulfate is the most frequently detected cause of allergic contact dermatitis in the world; the prevalence of nickel allergic contact dermatitis is between 8 and 11% in the general female population. Although it is well recognized that environmental factors are important in the pathogenesis of this dermatitis, some investigators have hypothesized that genetic factors are important as well. This review summarizes animal and human studies evaluating genetic factors in the development of allergic contact dermatitis from nickel.
Schram
Sarah E
SE
University of Minnesota, Minneapolis, and Veterans Affairs Medical Center, USA.
Warshaw
Erin M
EM
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000485:Allergens / Q000009:adverse effects*; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D023421:Models, Animal; D009532:Nickel / Q000009:adverse effects*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; D000485:Allergens; D006680:HLA Antigens; D011948:Receptors, Antigen, T-Cell; C073119:TAP1 protein, human; C029938:nickel sulfate; D009532:Nickel