title: Superficial keratectomy and topical mitomycin C as therapy for a corneal squamous cell carcinoma in a dog.
abstract: A 10-year-old female West Highland white terrier was presented with refractory hyperplastic keratitis of the left cornea of one month's duration. At this time, a vascularised and rough lesion 5 mm in diameter was observed on the left cornea. No other abnormality was recognised on the affected eye. The corneal neoplasm was surgically removed and histologically diagnosed as a squamous cell carcinoma. For two months after the surgery, 0.04 percent mitomycin C (MMC) eye drops were applied as adjuvant chemotherapy. Primary corneal squamous cell carcinoma with no history of keratoconjunctivitis sicca is rare in dogs. In the present report, surgical removal of the neoplasm was combined with the topical administration of the anticancer drug mitomycin C and a good prognosis was obtained. The result indicates that the combination treatment used in this case may be an appropriate therapeutic choice for corneal squamous cell carcinoma in dogs.
authors.affiliation: Laboratory of Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Graduate School, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Karasawa
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D003131:Combined Modality Therapy; D003316:Corneal Diseases / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D048988:Corneal Surgery, Laser / Q000379:methods / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery*; D004285:Dogs; D005134:Eye Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D005260:Female; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D016685:Mitomycin