'Induction of inflammatory gene expression by THP-1 macrophages cultured in normocholesterolaemic hypertensive sera and modulatory effects of green tea polyphenols'.
Hypertension is a disorder controlled by multiple genes and inflammation and vascular remodelling of arteries have been implicated in pathogenesis of this disease. Green tea polyphenols (GrTPs) are rich in antioxidants and are known to inhibit inflammatory responses. A significant time-dependent increase in mRNA expression of both IL-6 and MMP-9 were observed in THP-1 macrophages when cultured in normocholesterolaemic hypertensive sera (P<0.05).
Mahajan
N
N
Dhawan
V
V
Sharma
G
G
Jain
S
S
Kaul
D
D
D000975:Antioxidants / Q000494:pharmacology*; D002478:Cells, Cultured; D005419:Flavonoids / Q000494:pharmacology*; D015870:Gene Expression; D006801:Humans; D006973:Hypertension / Q000097:blood*; D015850:Interleukin-6 / Q000235:genetics*; D008264:Macrophages / Q000502:physiology*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D059808:Polyphenols; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013662:Tea
D000975:Antioxidants; D005419:Flavonoids; D015850:Interleukin-6; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D012333:RNA, Messenger; D013662:Tea; D020780:Matrix Metalloproteinase 9