title: Risk assessment of occupational exposure to polycyclic aromatic hydrocarbons by means of urinary1-hydroxypyrene.
abstract: Polycyclic aromatic hydrocarbons have mutagenic and carcinogenic properties and some of them are classified as probable or possible human carcinogens. Aim of this study was to evaluate the genotoxic risk in workers exposed to diesel exaust. Environmental and biological monitoring exposure to polycyclic aromatic hydrocarbons was carried out on fifty-two workers exposed to diesel exhaust. Urinary 1-hydroxypyrene was employed as a biomarker of internal dose. Significant urinary 1-hydroxypyrene differences between smokers and non-smokers were found. Twenty per cent of urinary 1-hydroxypyrene values exceeded benchmark level for genotoxic effect, while the results of environmental monitoring excluded the existence of exposure to polycyclic aromatic hydrocarbons. In the absence of greater knowledge about the relationship between urinary 1-hydroxypyrene and genotoxic effects under the conditions of very low exposure, extreme caution is recommended when this biomarker of internal dose is employed as an indicator of genotoxic risk.
authors.affiliation: Department of Traumathology, Orthopaedic and Occupational Medicine, University of Torino, Via Zuretti 29, 10126 Torino, Italy. giovanni.maina@unito.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Maina
authors.forename: Marco
authors.initials: M
authors.lastname: Manzari
authors.forename: Antonio
authors.initials: A
authors.lastname: Palmas
authors.forename: Valter
authors.initials: V
authors.lastname: Passini
authors.forename: Francesca Larese
authors.initials: FL
authors.lastname: Filon
mesh_terms: D000395:Air Pollutants, Occupational / Q000633:toxicity / Q000652:urine; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000652:urine; D004784:Environmental Monitoring; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008297:Male; D009152:Mutagenicity Tests; D016273:Occupational Exposure / Q000009:adverse effects*; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity* / Q000652:urine; D018570:Risk Assessment; D012907:Smoking / Q000009:adverse effects / Q000652:urine; D011795:Surveys and Questionnaires; D020711:Threshold Limit Values; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D011084:Polycyclic Aromatic Hydrocarbons; D001335:Vehicle Emissions; D003404:Creatinine