title: [Changes in epithelium transport system function and morphological indexes in the colon mucosa of rats with hypergastrinemia of different duration].
abstract: The role of gastrin in epithelium water and electrolyte (Na+, K+, CI-) transport in comparison with mucosal morphological indexes (crypt depth, thickness of colonic mucosa and epitheliocytes nuclear profound area) was investigated by using of omeprazole-induced (OM) hypergastrinemia model (for 1-4 weeks) and in vivo perfusing technique in rats. Short-term hypergastrinemia (for 1-2 weeks) caused the alterations in electroneutral absorption of NaCl. Prolongation of hypergastrinemia influence up to 3 weeks had entailed the first manifestation of the trophic effect on colonic mucosa expressed in alterations of electrogenic sodium absorption and increased crypt depth with a thickened colonic mucosa. Prolonged OM-induced hypergastrinemia (for 4 weeks) had led to decreased colonocytes differentiation level with an increased crypt depth, a thickened colonic mucosa and decreased epitheliocytes nuclear profound area which in turn have provoked the decreasing in net water and NaCl absorption.
authors.forename: T M
authors.initials: TM
authors.lastname: Hurlenko
authors.forename: O K
authors.initials: OK
authors.lastname: Voronina
authors.forename: V M
authors.initials: VM
authors.lastname: Hryshchuk
authors.forename: H M
authors.initials: HM
authors.lastname: Tolstanova
authors.forename: M E
authors.initials: ME
authors.lastname: Dzerzhyns'kyĭ
authors.forename: T V
authors.initials: TV
authors.lastname: Berehova
mesh_terms: D000818:Animals; D001692:Biological Transport; D002712:Chlorides / Q000378:metabolism; D003106:Colon / Q000378:metabolism / Q000473:pathology; D005755:Gastrins / Q000097:blood / Q000502:physiology*; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008297:Male; D009853:Omeprazole / Q000494:pharmacology; D010477:Perfusion; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism; D014882:Water-Electrolyte Balance
chemical_list: D002712:Chlorides; D005755:Gastrins; D012964:Sodium; D009853:Omeprazole; D011188:Potassium