MUC-1 gene is associated with prostate cancer death: a 20-year follow-up of a population-based study in Sweden.
Anti-adhesion mucins have proven to play an important part in the biology of several types of cancer. Therefore, we test the hypothesis that altered expression of MUC-1 is associated with prostate cancer progression. We retrieved archival tumour tissue from a population-based cohort of 195 men with localised prostate cancer (T1a-b, Nx, M0) that has been followed for up to 20 years with watchful waiting. Semi-automated, quantitative immunohistochemistry was undertaken to evaluate MUC-1 expression. We modelled prostate cancer-specific death as a function of MUC-1 levels accounting for age, Gleason grade and tumour extent, and calculated age-adjusted and multivariate adjusted hazard ratios (HR). Men that had tumours with an MUC-intensity lower or higher than normal tissue had a higher risk of dying in prostate cancer, independent of tumour extent and Gleason score (HR 5.1 and 4.5, respectively). Adjustment for Gleason grade and tumour stage did not alter the results. Men with a Gleason score > or =7 and MUC-1 deviating from the normal had a 17 (RR=17.1 95% confidence interval=2.3-128) times higher risk to die in prostate cancer compared with men with Gleason score <7 and normal MUC-1 intensity. In summary, our data show that MUC-1 is an independent prognostic marker for prostate cancer death.
Andrén
O
O
Department of Urology, Orebro University Hospital, Orebro, Sweden. ove.andren@orebroll.se
Fall
K
K
Andersson
S-O
SO
Rubin
M A
MA
Bismar
T A
TA
Karlsson
M
M
Johansson
J-E
JE
Mucci
L A
LA
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D018450:Disease Progression; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins / Q000235:genetics* / Q000378:metabolism*; D015999:Multivariate Analysis; D016017:Odds Ratio; D010446:Peptide Fragments / Q000235:genetics* / Q000378:metabolism*; D011159:Population Surveillance; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000401:mortality*; D040081:Protein Array Analysis; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D013548:Sweden / Q000453:epidemiology
D014408:Biomarkers, Tumor; C520326:MUC-1 protein, human (950-958); D018396:Mucin-1; D009077:Mucins; D010446:Peptide Fragments