title: Salutary effects of Corydalis yanhusuo extract on cardiac hypertrophy due to pressure overload in rats.
abstract: We have evaluated the effects of an alcohol extract from the rhizome of Corydalis yanhusuo W. T. (CY), a well-known traditional Chinese medicinal herb, on pressure-overloaded cardiac hypertrophy induced by transverse abdominal aorta constriction (TAAC) in rats. Rats were given vehicle or CY extract (200 or 50 mg kg(-1) per day) from the second week after induction of pressure overload, for a period of 7 weeks. Haemodynamic parameters, relative heart weight and myocyte cross-sectional area were measured in each group. We also estimated left ventricular (LV) collagen volume fraction (CVF) using Masson trichrome staining, and type I collagen expression by Western blot assay. Chronic TAAC caused notable cardiac hypertrophy and heart dysfunction. Significant collagen deposition and greater type I collagen expression were found in model control rats. These changes were not significantly reversed after treatment with 50 mg kg(-1) CY, whereas 200 mgkg(-1) significantly improved heart function and prevented cardiac hypertrophy, with parallel reductions in myocardial fibrosis, as evidenced by reduced LV CVF and reduced levels of type I collagen. In conclusion, chronic treatment of rats with CY extract attenuated development of cardiac hypertrophy.
authors.affiliation: Zhejiang Traditional Chinese Medical University, Binwen Road, Binjiang District, Hangzhou 310053, PR China.
authors.forename: Chengping
authors.initials: C
authors.lastname: Wen
authors.forename: Limao
authors.initials: L
authors.lastname: Wu
authors.forename: Haiyun
authors.initials: H
authors.lastname: Ling
authors.forename: Lianda
authors.initials: L
authors.lastname: Li
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000188:drug therapy* / Q000503:physiopathology; D003094:Collagen / Q000378:metabolism; D024042:Collagen Type I / Q000378:metabolism; D031311:Corydalis / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004719:Endomyocardial Fibrosis / Q000188:drug therapy; D015870:Gene Expression; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008516:Medicine, Chinese Traditional; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy*
chemical_list: D024042:Collagen Type I; D010936:Plant Extracts; D003094:Collagen