Prevalence of hypospadias in the same geographic region as ascertained by three different registries.
Hypospadias birth prevalence may be increasing with maternal exposure to endocrine disrupters. Yet hypospadias registers are hindered by data quality concerns. We compare the birth prevalence per thousand male births (BP) and ascertainment of hypospadias in the South East of England between 1st January 1997 to 31st September 1998 in a population-based hypospadias case register (surgeons' register) 731 cases, BP 3.8, (95% confidence interval 3.7-3.9), the National Congenital Anomaly System (NCAS) 645 cases (88% of surgeons' register), BP 3.4, (95% confidence interval 3.29-3.5) and Hospital Episode Statistics (HES) 221 cases (30% of the surgeons register), BP 1.15 (95% confidence interval 1.1-1.2). There were 191,438 male births (National Statistics). We found considerable differences in birth prevalence estimates and ascertainment according to data source. Compared with the Surgeons' register, the HES under-ascertainment of 10% was possibly explained by procedural weaknesses. NCAS's 70% under-ascertainment is explained by exclusion of so-called mild hypospadias (since 1990). This exclusion does not appear warranted since mild and severe hypospadias probably share aetiology and all require surgery. NCAR's utility could be improved if it returned to including "minor" hypospadias. Meanwhile routine data such as HES are potentially suitable for surveillance of this condition.
Nelson
Paul
P
Department of Epidemiology and Public Health, Imperial College School of Clinical Medicine, Norfolk Place, London W2 1PG. p.nelson@imperial.ac.uk
Nieuwenhuijsen
Mark
M
Jensen
Tina Kold
TK
Mouriquand
Pierre
P
Hughes
Ieuan
I
Wilcox
Duncan
D
Elliott
Paul
P
D052244:Endocrine Disruptors / Q000009:adverse effects; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D007021:Hypospadias / Q000453:epidemiology* / Q000209:etiology* / Q000601:surgery; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D012042:Registries; D012189:Retrospective Studies
D052244:Endocrine Disruptors