title: Inflammation, endothelial dysfunction and angiogenesis markers in chronic heart failure patients.
abstract: This study was conducted to assess the relationship among circulating markers of inflammation, endothelial dysfunction and angiogenesis in 59 chronic heart failure (CHF) patients. Increased concentrations of C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha), von Willebrand factor (VWF) and fibrinogen are strongly implicated in the development of CHF. Increased vascular endothelium grow factor (VEGF) and decreased thrombospondin-1 (TSP-1) concentrations suggest a role of angiogenesis in the maintenance and repair of luminal endothelium in CHF. A relationship among markers of endothelial dysfunction (VWF) and inflammation (fibrinogen, CRP) and angiogenesis (VEGF, TSP-1) was found in CHF patients.
authors.forename: Virtudes
authors.initials: V
authors.lastname: Vila
authors.forename: Vicenta
authors.initials: V
authors.lastname: Martínez-Sales
authors.forename: Luis
authors.initials: L
authors.lastname: Almenar
authors.forename: Ignacio Sánchez
authors.initials: IS
authors.lastname: Lázaro
authors.forename: Piedad
authors.initials: P
authors.lastname: Villa
authors.forename: Edelmiro
authors.initials: E
authors.lastname: Reganon
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology*; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000097:blood*
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators