title: Comorbidities in UK patients at the start of renal replacement therapy (chapter 6).
abstract: Comorbidity returns have continued to improve, albeit slowly, with centres running Mediqal software having the highest rates of completeness. Diabetes as a primary renal diagnosis accounted for 20% of those starting RRT, but a further 7% had diabetes present as a comorbid condition. The incidence of smoking remained high at 17% of diabetic patients, which was similar to that found in non-diabetics. Twelve percent of the patients starting RRT had a previous myocardial infarction (MI) and 31% of those aged over 65 years starting RRT had ischaemic heart disease (IHD). Patients starting on peritoneal dialysis (PD) were on average 9 years younger than those on haemodialysis (HD) and had fewer comorbidities present. Patients starting RRT without any comorbidity present had a lower median estimated glomerular filtration rate (eGFR) than those with comorbid conditions. Patients with a previous MI or coronary artery bypass grafting (CABG), started RRT with slightly higher mean haemoglobin than those without comorbid conditions or other comorbid conditions. On univariate survival analysis, diabetes was not associated with an increased risk of death amongst patients aged over 65 years, possibly due to its close association with other comorbidities in this age group. In the multivariate survival analysis, the presence of ischaemic/neuropathic ulcers was the predictor of worst survival, followed by malignancy, previous MI and age per 10 year increment. Smoking was less common in both South Asian and black patients than whites (7 vs 17%) starting RRT. Twenty-three percent of both South Asian and white patients started RRT with IHD compared with only 12% of Black patients.
authors.affiliation: UK Renal Registry, Southmead Hospital, Bristol BS10 5NB. Charlie.tomson@nbt.nhs.uk
authors.forename: Charlie
authors.initials: C
authors.lastname: Tomson
authors.forename: Uday
authors.initials: U
authors.lastname: Udayaraj
authors.forename: Julie
authors.initials: J
authors.lastname: Gilg
authors.forename: David
authors.initials: D
authors.lastname: Ansell
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000208:ethnology; D006801:Humans; D015994:Incidence; D007674:Kidney Diseases / Q000453:epidemiology* / Q000208:ethnology / Q000628:therapy*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000208:ethnology; D017202:Myocardial Ischemia / Q000453:epidemiology* / Q000208:ethnology; D012042:Registries / Q000706:statistics & numerical data; D017582:Renal Replacement Therapy / Q000706:statistics & numerical data*; D006113:United Kingdom / Q000453:epidemiology