[Carbamazepine hepatoxicity--a case report].
An acute liver damage with jaun. dice and biochemical abnormalities developed in 16-year-old adolescent, affected by chronic hepatitis B, after 3 years of carbamazepine therapy. The maximum bilirubin concentration in the blood was 445 micromol/L and the highest activity of AST, ALT, PA, GTP were noted, 648 U/L, 1497 U/L, 312 U/L, 85 U/L respectively. INR was 1.59. The blood ammonia level was elevated to 60.9 micromol/L. The carbamazepine treatment was stopped and laboratory parameters improved.
Gawlikowski
Tomasz
T
Oddział (Kliniczny) Toksykologii i Chorób Srodowiskowych WSS im. L. Rydygiera w Krakowie. togawlik@mp.pl
Hydzik
Piotr
P
D000293:Adolescent; D002220:Carbamazepine / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D004827:Epilepsy / Q000188:drug therapy; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006801:Humans; D017093:Liver Failure / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D016896:Treatment Outcome
D006514:Hepatitis B Surface Antigens; D002220:Carbamazepine