RecQ helicases and topoisomerases: implications for genome stability in humans.
In recent years growing evidence has suggested that the RecQ helicases play a crucial role in preserving genome stability. The importance of this observation in humans is substantiated by the fact that the absence of a functional RecQ helicase is associated with genetic syndromes characterised by elevated predisposition to a wide variety of cancers. It is well recognized that maintenance of genome integrity relies on the accurate execution of the DNA replication process as well as on efficient DNA repair. A number of studies have described interactions of RecQ helicases with topoisomerases and it has been proposed that this cooperation may be essential for cell viability and the avoidance of cancer development in human cells.
Franchitto
Annapaola
A
Section of Experimental and Computational Carcinogenesis, Istituto Superiore di Sanità, Rome, Italy. annapaola.franchitto@iss.it
D002470:Cell Survival; D004260:DNA Repair; D004261:DNA Replication; D026942:DNA Topoisomerases / Q000235:genetics / Q000378:metabolism*; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D042822:Genomic Instability; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D053484:RecQ Helicases / Q000235:genetics / Q000378:metabolism*; D013577:Syndrome
D053484:RecQ Helicases; D026942:DNA Topoisomerases