title: The effect of consumption of selenium enriched rye/wheat sourdough bread on the body's selenium status.
abstract: The potential of selenium-enriched rye/wheat sourdough bread as a route for supplementing dietary selenium intakes is reported. In addition to their normal diets, 24 female volunteers (24 to 25 years old) were fed either selenium-enriched bread or non-enriched bread each day (68.02 and 0.84 microg selenium day(-1) respectively) for 4 weeks. The chemical form of the selenium in the bread had been characterised using HPLC-ICP-MS, which showed that 42% of the extractable selenium was present as selenomethionine. Plasma selenium levels and plasma platelet glutathione peroxidase (GPx1) activity were measured in the volunteers' blood over a 6-week period. A statistically significant difference (p = 0.001) was observed in the mean percentage change data, calculated from the plasma selenium level measurements for the enriched and control group, over the duration of the study. A comparable difference was not observed for the platelet GPx1 activity (p = 0.756), over the same period. Two weeks after cessation of the feeding stage, i.e., at t = 6 weeks, the mean percentage change value for the selenium plasma levels in the enriched group was still significantly elevated, suggesting that the absorbed selenium had been incorporated into the body's selenium reserves, and was then being slowly released back into the volunteers' blood.
authors.affiliation: Institute of General Food Chemistry, Technical University of Lodz, ul. Stefanowskiego 4/10, 90-24, Lodz, Poland. malbrysz@snack.p.lodz.pl
authors.forename: Malgorzata A
authors.initials: MA
authors.lastname: Bryszewska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Ambroziak
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Langford
authors.forename: Malcolm J
authors.initials: MJ
authors.lastname: Baxter
authors.forename: Alison
authors.initials: A
authors.lastname: Colyer
authors.forename: D John
authors.initials: DJ
authors.lastname: Lewis
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000378:metabolism; D001792:Blood Platelets / Q000201:enzymology; D001939:Bread / Q000032:analysis*; D005260:Female; D005527:Food, Fortified; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D009752:Nutritional Status; D012434:Secale; D012643:Selenium / Q000008:administration & dosage* / Q000097:blood*; D014908:Triticum
chemical_list: D000975:Antioxidants; D005979:Glutathione Peroxidase; D012643:Selenium