Radioimmunoguided surgery (RIGS), PET/CT image-guided surgery, and fluorescence image-guided surgery: past, present, and future.
(125)I-labeled anti-TAG-72 antibodies were applied in radioimmunoguided surgery (RIGS) to remove gross and occult tumors. It is challenging to handle (125)I-labeled materials. PET/CT image-guided surgery utilizes (18)FDG to monitor the biochemical activity of the tumor and to integrate pre- and postoperative imaging for complete tumor removal. PET/CT image-guided surgery only detects later stage disease. Fluorescence image-guided surgery using anti-TAG-72 antibodies may provide opportunities for intraoperative cancer detection of both gross and occult tumors.
Sun
Duxin
D
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Bloomston
Mark
M
Hinkle
George
G
Al-Saif
Osama Habib
OH
Hall
Nathan C
NC
Povoski
Stephen P
SP
Arnold
Mark W
MW
Martin
Edward W
EW
D000911:Antibodies, Monoclonal / Q000187:drug effects; D000912:Antibodies, Neoplasm / Q000187:drug effects; D000951:Antigens, Neoplasm / Q000276:immunology; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D005453:Fluorescence; D019788:Fluorodeoxyglucose F18; D005544:Forecasting; D015902:Gamma Cameras; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007457:Iodine Radioisotopes; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D016719:Radioimmunodetection / Q000639:trends; D019275:Radiopharmaceuticals; D025321:Surgery, Computer-Assisted / Q000639:trends; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; C091202:B72.3 antibody; D006023:Glycoproteins; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; C047052:tumor-associated antigen 72; D019788:Fluorodeoxyglucose F18