Cell and molecular biology of the spindle matrix.
The concept of a spindle matrix has long been proposed to account for incompletely understood features of microtubule spindle dynamics and force production during mitosis. In its simplest formulation, the spindle matrix is hypothesized to provide a stationary or elastic molecular matrix that can provide a substrate for motor molecules to interact with during microtubule sliding and which can stabilize the spindle during force production. Although this is an attractive concept with the potential to greatly simplify current models of microtubule spindle behavior, definitive evidence for the molecular nature of a spindle matrix or for its direct role in microtubule spindle function has been lagging. However, as reviewed here multiple studies spanning the evolutionary spectrum from lower eukaryotes to vertebrates have provided new and intriguing evidence that a spindle matrix may be a general feature of mitosis.
Johansen
Kristen M
KM
Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA.
Johansen
Jørgen
J
D021581:Active Transport, Cell Nucleus; D000818:Animals; D006801:Humans; D008938:Mitosis; D008967:Molecular Biology; D034521:Nuclear Matrix-Associated Proteins; D008941:Spindle Apparatus / Q000378:metabolism*
D034521:Nuclear Matrix-Associated Proteins