Activity against drug resistant-tuberculosis strains of plants used in Mexican traditional medicine to treat tuberculosis and other respiratory diseases.
Tuberculosis (TB) kills about 3 million people per year worldwide. Furthermore, TB is an infectious disease associated with HIV patients, and there is a rise in multidrug-resistant TB (MDR-TB) cases around the world. There is a need for new anti-TB agents. The study evaluated the antimycobacterial activity of nine plants used in Mexican traditional medicine to treat tuberculosis and other respiratory diseases. Nasturtium officinale showed the best activity (MIC = 100 microg/mL) against the sensitive Mycobacterium tuberculosis. The following plants were active also but at 200 microg/mL: Citrus sinensis, Citrus aurantifolia, Foeniculum vulgare, Larrea tridentata, Musa acuminata and Olea europaea. Contrary to the above data, activity against drug-resistant variants of M. tuberculosis was more evident, e.g. N. officinale was the most potent (MIC < or = 100 microg/mL) against the four mono-resistant variants tested; F. vulgare and O. europaea were active against all the resistant variants (MICs < or = 100 microg/mL). The most susceptible variant was the isoniazid resistant, being inhibited by C. aurantifolia, C. sinensis and O. europaea (MIC = 25 microg/mL). These data point to the importance of biological testing of extracts against drug-resistant M. tuberculosis isolates, and the bioguided assay of these extracts for the identification of lead compounds against MDR-TB isolates.
Camacho-Corona
María Del Rayo
Mdel R
Laboratorio de Química de Productos Naturales, Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Mexico. mrayocamacho@yahoo.com.mx
Ramírez-Cabrera
Mónica A
MA
Santiago
Omar González-
OG
Garza-González
Elvira
E
Palacios
Isidoro de Paz
Ide P
Luna-Herrera
Julieta
J
D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D032084:Citrus sinensis / Q000737:chemistry; D030001:Foeniculum / Q000737:chemistry; D006801:Humans; D032442:Larrea / Q000737:chemistry; D008519:Medicine, Traditional; D008800:Mexico; D008826:Microbial Sensitivity Tests; D028521:Musa / Q000737:chemistry; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D031223:Nasturtium / Q000737:chemistry; D031658:Olea / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012120:Respiration Disorders / Q000188:drug therapy; D018088:Tuberculosis, Multidrug-Resistant / Q000382:microbiology*
D000995:Antitubercular Agents; D010936:Plant Extracts