title: Islet beta-cell death - fuel to sustain autoimmunity?
abstract: Under what context do dying beta-cells enhance the autoimmune process in type 1 diabetes? Kim et al. (2007) find that secondary necrosis of beta-cells can prime the autoimmune response via uptake by and activation of antigen-presenting cells through Toll-like receptor 2.
authors.affiliation: La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. christophe@liai.org
authors.forename: Christophe M
authors.initials: CM
authors.lastname: Filippi
authors.forename: Matthias G
authors.initials: MG
authors.lastname: von Herrath
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D017209:Apoptosis; D015551:Autoimmunity / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D050417:Insulin-Secreting Cells / Q000276:immunology / Q000473:pathology*; D051379:Mice; D009336:Necrosis; D051195:Toll-Like Receptor 2 / Q000378:metabolism*
chemical_list: D051195:Toll-Like Receptor 2