title: The impact of different closure materials on pharyngeal wound healing: an experimental animal study.
abstract: The formation of pharyngo-cutaneous fistula (PCF) is controversial and various predisposing factors have been proposed. This study aimed to compare different suture materials in the closure of pharyngeal wounds in experimental animals. Fifty-two Sprague-Dawley rats were divided into three groups. Artificial pharyngotomy was performed and was then repaired with Vicryl, polypropylene, and Vicryl plus fibrin glue, respectively. Outcome measurements included gross wound inspection and histological examination. There was a significant difference in the rates of PCF formation between group I and group II (Fisher's exact test, p = 0.046). In addition, minimal inflammatory response was found in the polypropylene group when compared to the other groups. The fibrin glue-treated group had the highest fibroblast activity and collagen deposition. Polypropylene produced minimal tissue reaction, which facilitated the healing process. Therefore, proper selection of suture material can probably reduce the rate of PCF but should not be substituted for proper aseptic and meticulous surgical techniques.
authors.affiliation: Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Shih-An
authors.initials: SA
authors.lastname: Liu
authors.forename: Kwong-Chung
authors.initials: KC
authors.lastname: Tung
authors.forename: Ching-Chang
authors.initials: CC
authors.lastname: Cheng
authors.forename: Yung-Tsung
authors.initials: YT
authors.lastname: Chiu
mesh_terms: D000818:Animals; D017577:Cutaneous Fistula / Q000473:pathology* / Q000601:surgery*; D015718:Fibrin Tissue Adhesive; D010608:Pharyngeal Diseases / Q000473:pathology* / Q000601:surgery*; D011126:Polypropylenes; D011446:Prospective Studies; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013536:Suture Techniques; D013537:Sutures; D014945:Wound Healing
chemical_list: D015718:Fibrin Tissue Adhesive; D011126:Polypropylenes