Case of corneal melting associated with the use of topical nepafenac.
OBJECTIVE
To report a case of corneal melting associated with the use of the topical nonsteroidal anti-inflammatory agent Nepafenac.


METHODS
Case report and literature review.


RESULTS
A 62-year-old woman with a complicated ocular history developed corneal melting associated with the use of Nepafenac. On discontinuation of Nepafenac, the melt rapidly resolved.


CONCLUSIONS
Topical nonsteroidal anti-inflammatory agents have been associated with corneal ulceration and stromal melts. This is, to our knowledge, the first reported case involving the new agent, Nepafenac.
Bekendam
Peter D
PD
Department of Ophthalmology, Loma Linda University Medical Center, Loma Linda, CA, USA.
Narváez
Julio
J
Agarwal
Madhu
M
D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D044482:Benzeneacetamides / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects*; D003320:Corneal Ulcer / Q000139:chemically induced* / Q000175:diagnosis; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy; D010648:Phenylacetates / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D044482:Benzeneacetamides; D010648:Phenylacetates; C414203:nepafenac