title: Differentiating biological correlates of risk, PTSD, and resilience following trauma exposure.
abstract: Risk and resilience factors presumably explain the individual differences in the response to adversity. However, little is known about how such factors are related. Risk and protective factors may reflect a quantitative difference along a single dimension (e.g., low IQ might be associated with risk and high IQ with resilience); however, they may also refer to orthogonal constructs that interact and/or moderate stress effects to increase or diminish the probability of developing trauma-related psychopathology (e.g., good coping could offset low IQ). The authors illustrate experimental strategies for distinguishing between these possibilities for any putative measure relating to symptom development, using a database that includes published and unpublished psychological and biological variables from a relatively homogenous cohort of exposed and nonexposed veterans.
authors.affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, and Department of Psychiatry, Bronx VAMC, Bronx, NY 10468, USA. rachel.yehuda@va.gov
authors.forename: Rachel
authors.initials: R
authors.lastname: Yehuda
authors.forename: Janine D
authors.initials: JD
authors.lastname: Flory
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology; D000368:Aged; D000369:Aged, 80 and over; D003130:Combat Disorders / Q000503:physiopathology / Q000523:psychology*; D003687:Dehydroepiandrosterone / Q000097:blood*; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood*; D011379:Prognosis; D011599:Psychopathology; D011965:Receptors, Glucocorticoid / Q000502:physiology; D012307:Risk Factors; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology / Q000523:psychology*
chemical_list: D009478:Neuropeptide Y; D011965:Receptors, Glucocorticoid; D003687:Dehydroepiandrosterone