Quinic acid esters from Pluchea indica with collagenase, MMP-2 and MMP-9 inhibitory activities.
Investigation of collagenase inhibitory natural components afforded two quinic acid esters (1 and 2) and quercetin (3) from the leaves of Pluchea indica (Compositae). Of these, compounds 1 and 2 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 10 microm, and 1 showed matrix metalloproteinase (MMP)-2 and -9 inhibitory activity (IC(50)) at 2.5 and 6.4 microm, respectively.
Ohtsuki
Takashi
T
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Yokosawa
Emiko
E
Koyano
Takashi
T
Preeprame
Srisomporn
S
Kowithayakorn
Thaworn
T
Sakai
Shinobu
S
Toida
Toshihiko
T
Ishibashi
Masami
M
D019659:Asteraceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004952:Esters; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011801:Quinic Acid / Q000737:chemistry / Q000494:pharmacology*
D004952:Esters; D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts; D011801:Quinic Acid