Balancing mucosal immunity: caught between CYLD and Charybdis.
The molecular mechanism of acute lung injury caused by Streptococcus pneumoniae is unclear. In this issue of Immunity, Lim et al. (2007) demonstrate that CYLD, a deubiquinating enzyme, represses the expression of plasminogen activator inhibitor-1, which is critical in preventing tissue damage.
Kolls
Jay K
JK
Children's Hospital of Pittsburgh, Suite 3765, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA. jay.kolls@chp.edu
D000818:Animals; D003546:Cysteine Endopeptidases / Q000235:genetics / Q000502:physiology*; D000074749:Deubiquitinating Enzyme CYLD; D018928:Immunity, Mucosal; D051379:Mice; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D011018:Pneumonia, Pneumococcal / Q000201:enzymology* / Q000276:immunology; D020545:Respiratory Mucosa / Q000201:enzymology* / Q000276:immunology
D017395:Plasminogen Activator Inhibitor 1; C511601:CYLD protein, mouse; D000074749:Deubiquitinating Enzyme CYLD; D003546:Cysteine Endopeptidases