[Changes in epithelium transport system function and morphological indexes in the colon mucosa of rats with hypergastrinemia of different duration].
The role of gastrin in epithelium water and electrolyte (Na+, K+, CI-) transport in comparison with mucosal morphological indexes (crypt depth, thickness of colonic mucosa and epitheliocytes nuclear profound area) was investigated by using of omeprazole-induced (OM) hypergastrinemia model (for 1-4 weeks) and in vivo perfusing technique in rats. Short-term hypergastrinemia (for 1-2 weeks) caused the alterations in electroneutral absorption of NaCl. Prolongation of hypergastrinemia influence up to 3 weeks had entailed the first manifestation of the trophic effect on colonic mucosa expressed in alterations of electrogenic sodium absorption and increased crypt depth with a thickened colonic mucosa. Prolonged OM-induced hypergastrinemia (for 4 weeks) had led to decreased colonocytes differentiation level with an increased crypt depth, a thickened colonic mucosa and decreased epitheliocytes nuclear profound area which in turn have provoked the decreasing in net water and NaCl absorption.
Hurlenko
T M
TM
Voronina
O K
OK
Hryshchuk
V M
VM
Tolstanova
H M
HM
Dzerzhyns'kyĭ
M E
ME
Berehova
T V
TV
D000818:Animals; D001692:Biological Transport; D002712:Chlorides / Q000378:metabolism; D003106:Colon / Q000378:metabolism / Q000473:pathology; D005755:Gastrins / Q000097:blood / Q000502:physiology*; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008297:Male; D009853:Omeprazole / Q000494:pharmacology; D010477:Perfusion; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism; D014882:Water-Electrolyte Balance
D002712:Chlorides; D005755:Gastrins; D012964:Sodium; D009853:Omeprazole; D011188:Potassium