title: YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008.
abstract: In the course of screening for drugs that suppress the Ca(2+)-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca(2+)-signaling. A novel pyrano-pyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca(2+)-induced growth inhibition of the Saccharomyces cerevisiae (Deltazds1Deltasyr1) mutant.
authors.affiliation: BioFrontier Laboratories, Kyowa Hakko Kogyo Co. Ltd., Tokyo, Japan.
authors.forename: Fumito
authors.initials: F
authors.lastname: Koizumi
authors.forename: Naomi
authors.initials: N
authors.lastname: Fukumitsu
authors.forename: Jinrong
authors.initials: J
authors.lastname: Zhao
authors.forename: Ruthada
authors.initials: R
authors.lastname: Chanklan
authors.forename: Tokichi
authors.initials: T
authors.lastname: Miyakawa
authors.forename: Shoko
authors.initials: S
authors.lastname: Kawahara
authors.forename: Shin
authors.initials: S
authors.lastname: Iwamoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Suzuki
authors.forename: Shingo
authors.initials: S
authors.lastname: Kakita
authors.forename: Endang S
authors.initials: ES
authors.lastname: Rahayu
authors.forename: Seijiro
authors.initials: S
authors.lastname: Hosokawa
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Tatsuta
authors.forename: Michio
authors.initials: M
authors.lastname: Ichimura
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D020013:Calcium Signaling / Q000187:drug effects*; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005670:Fusarium; D006801:Humans; D011714:Pyrans / Q000494:pharmacology*; D011728:Pyridones / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D011714:Pyrans; D011728:Pyridones; C524346:YCM 1008A