title: Does elevated high-sensitivity serum C-reactive protein associate with hypertension in non-obese Japanese males?
abstract: The object of this study is to assess whether elevated hsCRP levels are independently related to hypertension in non-obese Japanese males. This cross-sectional study comprised 86 hypertensive and 109 normotensive subjects. We defined hypertension as a systolic blood pressure >/=140 mmHg and/or a diastolic blood pressure >/=90 mmHg and/or taking antihypertensive therapy. Log-hsCRP levels were significantly higher in hypertensive than normotensive subjects. In logistic regression analysis, subjects in the highest tertile had a two-fold higher risk than those in the lowest tertile. The association between hypertension and hsCRP levels was marginally significant. In addition, there was a significant tendency for hypertension to increase with an increase in CRP level (p < .05). These findings suggest that elevated hsCRP level is an independent risk factor for hypertension in non-obese Japanese males.
authors.affiliation: Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan. imatoh@cis.fukuoka-u.ac.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Imatoh
authors.forename: Motonobu
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Une
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D015415:Biomarkers; D001835:Body Weight; D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D003430:Cross-Sectional Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology; D007564:Japan; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein