The expanding universe of regulatory T cell subsets in cancer.
Evidence has indicated that failed antitumor immunity is dominated by immunosuppressive mechanisms within the tumor microenvironment. In this issue of Immunity, Peng et al. (2007) add to this list by describing tumor-infiltrating gammadelta T cells that have regulatory function.
Gajewski
Thomas F
TF
University of Chicago, Chicago, IL 60637, USA. tgajewsk@medicine.bsd.uchicago.edu
D000818:Animals; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta