TIM family proteins and autoimmunity.
Despite their relative novelty, a growing body of literature now demonstrates that T cell immunoglobulin and mucin domain (TIM) family proteins are important regulators of immunity. Not surprisingly, these proteins also play prominent roles in the control of auto-reactive immune responses. Thus, modulation of TIM protein function may prove to be a useful strategy to control autoimmune diseases.
Kane
Lawrence P
LP
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. lkane@pitt.edu
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000378:metabolism; D015551:Autoimmunity; D037161:Galectins / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D037161:Galectins; D008565:Membrane Proteins