Nucleotide formation as a determinant of 5-Fluorouracil response in mouse leukemias.
Survival of mice bearing different transplantable leukemias and treated with 5-fluorouracil was compared with accumulation of drug nucleotides in vitro. There was significant correlation,suggesting that cellular capacity for conversion of the drug to nucleotides is a major determinant of inherent drug sensitivity of these leukemias.
Kessed
D
D
Hall
T C
TC
Wodinsky
I
I