The sentinel concept in patients with cervical cancer.
The sentinel concept for patients with early cervical cancer has a high potential for decreasing morbidity and for increasing oncologic safety. The detection rate with technetium-labeling or a combination with blue dye varies between 84% and 92%. Sensitivity and negative predictive value depend on tumor size: the smaller the tumor, the higher the validity of the technique. Detection of circulating tumor cells in the sentinel node using HPVmRNA as marker may have a good prognostic value. Currently the sentinel concept should only be used in clinical studies before its validity has been proved.
Schneider
Achim
A
Department of Gynecology and Gynecologic Oncology, Charité, Berlin, Germany. achim.schneider@charite.de
D004396:Coloring Agents; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008197:Lymph Node Excision / Q000379:methods*; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology*; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D013671:Technetium Tc 99m Sulfur Colloid; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery
D004396:Coloring Agents; D019275:Radiopharmaceuticals; D013671:Technetium Tc 99m Sulfur Colloid