title: Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in bipolar disorder.
abstract: Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. The aim of this study was to examine the association between polymorphisms in CRF-BP gene and bipolar disorder in an isolated Swedish population. One hundred and eighty-two patients with bipolar I disorder and 333 controls from Northern Sweden were included in the study. Five single nucleotide polymorphisms and a deletion polymorphism in the CRF-BP gene were genotyped. The haplotype block structure of the gene was considered and the expectation maximization algorithm was adopted to estimate the haplotype frequencies. As a result, there were no significant associations of the different polymorphisms in the CRF-BP gene with bipolar disorder. In conclusion, this study in an isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder.
authors.affiliation: Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Antwerp, Belgium.
authors.forename: Filip
authors.initials: F
authors.lastname: Van Den Eede
authors.forename: Tine
authors.initials: T
authors.lastname: Venken
authors.forename: Ann
authors.initials: A
authors.lastname: Van Den Bogaert
authors.forename: Jurgen
authors.initials: J
authors.lastname: Del-Favero
authors.forename: Karl-Fredrik
authors.initials: KF
authors.lastname: Norrback
authors.forename: Lars Göran
authors.initials: LG
authors.lastname: Nilsson
authors.forename: Rolf
authors.initials: R
authors.lastname: Adolfsson
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: Stephan J
authors.initials: SJ
authors.lastname: Claes
mesh_terms: D000465:Algorithms; D001714:Bipolar Disorder / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D013548:Sweden
chemical_list: D002352:Carrier Proteins; C067133:corticotropin releasing factor-binding protein