[Heme oxygenase as a potential therapeutic target for hepatoprotection].
Heme oxygenase (HO) is the rate limiting enzyme in the breakdown of heme into carbon monoxide (CO), iron and biliverdin. To date three mammalian HO isozymes have been identified, and only one of them (HO-1) is inducible. The products of HO-catalyzed reaction, particularly CO and biliverdin/bilirubin have been shown to exert protective effects in the liver against different noxious stimuli. The results of experimental data show that induction of HO-1 expression contributes to protection against liver damage induced by several chemical compounds such as acetaminophen.
Chodorowski
Zygmunt
Z
Katedra i Klinika Chorób Wewnetrznych, Geriatrii i Toksykologii Klinicznej, Akademii Medycznej w Gdańsku.
Sein Anand
Jacek
J
Rybakowska
Iwona
I
Kaletha
Krystian
K
D000082:Acetaminophen / Q000009:adverse effects; D000818:Animals; D001664:Biliverdine / Q000378:metabolism; D002248:Carbon Monoxide / Q000378:metabolism; D002384:Catalysis / Q000187:drug effects; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury; D019610:Cytoprotection / Q000187:drug effects; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control; D004790:Enzyme Induction; D005737:Garlic / Q000737:chemistry; D006418:Heme / Q000737:chemistry / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D051547:Heme Oxygenase-1 / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008107:Liver Diseases / Q000201:enzymology* / Q000517:prevention & control*; D018384:Oxidative Stress; D020011:Protective Agents / Q000494:pharmacology
D007527:Isoenzymes; D020011:Protective Agents; D000082:Acetaminophen; D006418:Heme; D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; D001664:Biliverdine