title: Aortic root replacement does not affect outcome and quality of life.
abstract: BACKGROUND
  Different studies have analyzed the potential impact of the underlying pathologic process and the use of deep hypothermic circulatory arrest on outcome and quality of life after surgery on the thoracic aorta. The aim of this study is to analyze the impact of different surgical procedures on outcome and quality of life.
  
  
  METHODS
  Between June 2001 and December 2003, 244 patients underwent surgery for various diseases of the ascending aorta with or without involvement of the aortic valve or root. They were divided according to the operative procedure: 76 patients (31.2%) underwent isolated replacement of the ascending aorta, 42 patients (17.2%) received separate aortic valve replacement and supracoronary replacement of the ascending aorta, 86 patients (35.2%) received a mechanical composite graft, and 40 patients (16.4%) received a biologic composite graft. All in-hospital data were assessed, and a follow-up was performed in all survivors after 26.6 +/- 8.8 months, focusing on outcome and quality of life (SF-36).
  
  
  RESULTS
  Overall in-hospital mortality was 6.1%, and late mortality was 5.7%, with no significant difference between groups. Independent of the surgical technique and the extent of surgery, there was no difference in quality of life between the surgical collective and an age-matched and sex-matched standard population.
  
  
  CONCLUSIONS
  Operations of the ascending aorta and aortic valve are very safe, with low in-hospital mortality and favorable midterm outcome regarding late mortality and morbidity. Quality of life after operations of the ascending aorta and aortic valve is equal to a standard population and is not affected by the surgical procedure. Liberal use of aortic root replacement is therefore justified to radically treat the diseased aortic segment.
authors.affiliation: Department of Cardiovascular Surgery, University Hospital, Berne, Switzerland. mario.stalder@insel.ch
authors.forename: Mario
authors.initials: M
authors.lastname: Stalder
authors.forename: Sabine
authors.initials: S
authors.lastname: Staffelbach
authors.forename: Franz F
authors.initials: FF
authors.lastname: Immer
authors.forename: Lars
authors.initials: L
authors.lastname: Englberger
authors.forename: Pascal A
authors.initials: PA
authors.lastname: Berdat
authors.forename: Friedrich S
authors.initials: FS
authors.lastname: Eckstein
authors.forename: Thierry P
authors.initials: TP
authors.lastname: Carrel
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta / Q000601:surgery*; D001021:Aortic Valve / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006324:Heart Arrest, Induced; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D011788:Quality of Life; D016896:Treatment Outcome