title: [Changes in lower urinary tract function in children with hyperactive urinary bladder treated with combined therapy].
abstract: Low clinical efficacy of M-cholinolytics remains a serious problem in conservative therapy of hyperactive bladder (HB). To improve treatment outcomes, combined therapy (pikamilon plus driptan) was tried in 22 boys and 25 girls aged 7 to 14 years. The children were examined with uroflowmetry, cystometry. The response to the treatment was found to depend on mean effective capacity of the urinary bladder. Duration ofurodynamic correction has a negative colleration with this capacity. Urodynamic investigations performed in different periods of therapy show that improvement of lower urinary tract function is pathogenetically important for treatment of children with urologic pathology running in the presence of hyperactive urinary bladder.
authors.forename: T I
authors.initials: TI
authors.lastname: Danilova
authors.forename: E V
authors.initials: EV
authors.lastname: Medvedeva
authors.forename: Zh B
authors.initials: ZhB
authors.lastname: Vasil'eva
authors.forename: V V
authors.initials: VV
authors.lastname: Danilov
mesh_terms: D000293:Adolescent; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000503:physiopathology; D014554:Urination / Q000187:drug effects*; D014563:Urodynamics / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D008333:Mandelic Acids; D018727:Muscarinic Antagonists; C044905:nicotinoyl-GABA; D005680:gamma-Aminobutyric Acid; C005419:oxybutynin