Translational control of long-term synaptic plasticity and memory storage by eIF2alpha.
Both long-lasting changes in synaptic function and long-term memory require gene expression. However, the molecular mechanisms by which gene expression is turned on are not fully understood. In this review, we highlight the role of the eukaryotic initiation factor 2 alpha (eIF2alpha) signalling pathway in long-term synaptic plasticity and memory.
Costa-Mattioli
Mauro
M
Department of Biochemistry, McGill Cancer Centre, Montreal, Québec, Canada. mauro.costa-mattioli@mail.mcgill.ca
Sonenberg
Nahum
N
D000818:Animals; D001921:Brain / Q000378:metabolism*; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008568:Memory / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D009473:Neuronal Plasticity / Q000502:physiology*; D014176:Protein Biosynthesis / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*
D015852:Eukaryotic Initiation Factor-2; D009419:Nerve Tissue Proteins