title: A two-part joint model for the analysis of survival and longitudinal binary data with excess zeros.
abstract: Many longitudinal studies generate both the time to some event of interest and repeated measures data. This article is motivated by a study on patients with a renal allograft, in which interest lies in the association between longitudinal proteinuria (a dichotomous variable) measurements and the time to renal graft failure. An interesting feature of the sample at hand is that nearly half of the patients were never tested positive for proteinuria (>/=1g/day) during follow-up, which introduces a degenerate part in the random-effects density for the longitudinal process. In this article we propose a two-part shared parameter model framework that effectively takes this feature into account, and we investigate sensitivity to the various dependence structures used to describe the association between the longitudinal measurements of proteinuria and the time to renal graft failure.
authors.affiliation: Biostatistical Centre, Catholic University of Leuven, U.Z. St. Rafaël, Kapucijnenvoer 35, B-3000 Leuven, Belgium. dimitris.rizopoulos@med.kuleuven.be
authors.forename: Dimitris
authors.initials: D
authors.lastname: Rizopoulos
authors.forename: Geert
authors.initials: G
authors.lastname: Verbeke
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Lesaffre
authors.forename: Yves
authors.initials: Y
authors.lastname: Vanrenterghem
mesh_terms: D001699:Biometry / Q000379:methods*; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D008137:Longitudinal Studies; D015233:Models, Statistical; D016016:Proportional Hazards Models; D012107:Research Design; D016019:Survival Analysis; D015996:Survival Rate