title: [Pathogenesis of mixed experimental infection caused by diarrheal viruses--bovine mucosal disease and bovine infectious rhinotracheitis in calves].
abstract: The pathogenesis of mixed experimental infection caused by intranasal inoculation of seronegative calves aged 4-6 months with bovine viral diarrhea-mucosal disease (BVDMD) (cytopathogenic) and infectious bovine rhinotracheitis (BRT) viruses, was studied. Consecutive injections of viruses resulted in acute respiratory disease that was severer and accompanied by necrotic rhinotracheitis and acute catarrhal bronchopneumonia than individual injections. BVDMD virus was reisolated from the samples taken from the respiratory tract, intestine, and lymphoid system. The longer excretion of BRT virus with nasal swabs and its high concentration in the respiratory organs suggests its more potent pathogenic properties during reproduction of BVDMD virus.
authors.forename: A G
authors.initials: AG
authors.lastname: Glotov
authors.forename: T I
authors.initials: TI
authors.lastname: Glotova
authors.forename: A N
authors.initials: AN
authors.lastname: Sergeev
authors.forename: I G
authors.initials: IG
authors.lastname: Drozdov
mesh_terms: D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000150:complications / Q000473:pathology / Q000821:virology*; D001996:Bronchopneumonia / Q000473:pathology; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral; D007242:Herpesvirus 1, Bovine; D007241:Infectious Bovine Rhinotracheitis / Q000150:complications / Q000473:pathology / Q000821:virology*; D007422:Intestines / Q000821:virology; D008198:Lymph Nodes / Q000821:virology; D009336:Necrosis / Q000473:pathology; D012137:Respiratory System / Q000821:virology; D012220:Rhinitis / Q000473:pathology; D014136:Tracheitis / Q000473:pathology