title: [Fenvalerate affects sperm motility in SD rats].
abstract: OBJECTIVE
  To observe the direct effects of fenvalerate (Fen) on sperm motility in SD rats.
  
  
  METHODS
  Sperm were isolated from caudal epididymides of healthy adult male rats with the diffusion method. The motility parameters of the isolated sperm, such as VCL, VSL, VAP, BCF, STR and LIN, were monitored by computer-assisted sperm analysis (CASA) system after 1, 2 and 4 h Fen-exposure in vitro at concentrations of 0, 1, 4, 16 and 64 micromol/L respectively.
  
  
  RESULTS
  After 1 and 2 h Fen-exposure, VSL, BCF, STR and LIN decreased significantly at 64 micromol/L compared with the control group. After 4 h Fen-exposure, the motility parameters VCL, VSL, BCF, STR and LIN dropped progressively at 64 micromol/L, and VCL declined markedly at 16 micromol/L. However, only VCL and STR showed alterations in a time-response manner.
  
  
  CONCLUSIONS
  Fen may affect the caudal epididymal sperm and produce a direct toxic effect on sperm motility in SD rats.
authors.affiliation: Institute of Toxicology, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Song
authors.forename: Yu-Bang
authors.initials: YB
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Sun
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Gu
authors.forename: Yang
authors.initials: Y
authors.lastname: Sun
authors.forename: Xin-Ru
authors.initials: XR
authors.lastname: Wang
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000633:toxicity; D008297:Male; D009570:Nitriles / Q000633:toxicity*; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects*
chemical_list: D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017690:fenvalerate