title: Anxiety and depression: main determinants of health-related quality of life in Brazilian patients with Parkinson's disease.
abstract: Determinants of health-related quality of life (HRQoL) were assessed in 115 Brazilian patients (56.5% males; mean age 62.5 years) with Parkinson's disease (PD). Hoehn and Yahr (H&Y) staging, Scales for Outcomes in Parkinson's Disease-Motor Scale (SCOPA-MS), Cumulative Illness Rating Scale-Geriatrics, Hospital Anxiety and Depression Scale (HADS), Parkinson's Disease Questionnaire (PDQ-39), and SCOPA-Psychosocial Questionnaire (SCOPA-PS) were applied. Median H&Y was 3 and the SCOPA-MS score was 25.6+/-13.1. The proportion of patients who scored > or =11 points in the HADS-Depression and HADS-Anxiety subscales were 47% and 30.4%, respectively. In the multivariate model, HADS-Anxiety or HADS-Depression (p<0.0001), disability (SCOPA-MS II) (p=0.0001) and comorbidity (p=0.0005) were independently associated to PDQ-39 and SCOPA-PS. Mood disturbances were the main determinants of HRQoL.
authors.affiliation: Neurology Department, Sarah Hospital, The Sarah Network of Rehabilitation Hospitals, SMHS Quadra 501 Conjunto A, CEP 70330-150, Brasilia DF, Brazil. javier@sarah.br <javier@sarah.br>
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Carod-Artal
authors.forename: Sofia
authors.initials: S
authors.lastname: Ziomkowski
authors.forename: Hudson
authors.initials: H
authors.lastname: Mourão Mesquita
authors.forename: Pablo
authors.initials: P
authors.lastname: Martínez-Martin
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000704:Analysis of Variance; D001007:Anxiety / Q000453:epidemiology / Q000209:etiology / Q000523:psychology*; D001938:Brazil / Q000453:epidemiology; D015897:Comorbidity; D003627:Data Interpretation, Statistical; D003863:Depression / Q000453:epidemiology / Q000209:etiology / Q000523:psychology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000150:complications / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012737:Sex Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires