Hemodynamic and metabolic changes during exercise in calves with total artificial hearts of different sizes yet similar output.
To evaluate the effects of downsizing of the total artificial heart (TAH), we compared the anaerobic threshold (AT) values in calves with two different types of TAH (Cleveland Clinic-Nimbus TAH and the downsized MagScrew TAH). Exercise studies were performed using a treadmill in 12 calves. During the exercise, parameters to obtain the AT were measured. To evaluate the determinants of the AT, a linear regression analysis was performed between AT and potential variables. AT values from 29 studies revealed no significant differences between the two different TAHs, with no significant differences in hemodynamic or oxygen metabolic parameters. AT values correlated well with pump flow/body weight (Q) multiplied by the hemoglobin level, regardless of the TAH used. In conclusion, downsizing of the original TAH design did not reduce AT without any significant differences in hemodynamic or oxygen metabolic parameters during exercise in calves.
Kamohara
Keiji
K
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Weber
Stephan
S
Klatte
Ryan S
RS
Luangphakdy
Viviane
V
Flick
Christine R
CR
Ootaki
Yoshio
Y
Akiyama
Masatoshi
M
Cingoz
Faruk
F
Ootaki
Chiyo
C
Kopcak
Michael W
MW
Liu
Jenny
J
Chen
Ji-Feng
JF
Navia
Jose L
JL
Smith
William A
WA
Fukamachi
Kiyotaka
K
D015308:Anaerobic Threshold; D000818:Animals; D001775:Blood Circulation; D002417:Cattle; D004867:Equipment Design; D006354:Heart, Artificial; D006454:Hemoglobins / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood*; D016014:Linear Models; D008422:Materials Testing; D008955:Models, Cardiovascular; D010101:Oxygen Consumption; D005082:Physical Exertion; D012107:Research Design
D006454:Hemoglobins; D019344:Lactic Acid