title: Preparation and characterization of solid dispersions of dipyridamole with a carrier "copolyvidonum Plasdone S-630".
abstract: Solid dispersions (SDs) of dipyridamole (DIP) with a novel carrier copolyvidonum Plasdone S-630 (CoPVP) were developed by solvent evaporation method. The solid state of SDs of DIP with CoPVP (SDs CoPVP) was characterized by fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and polarizing microscopy, compared with that of SDs of DIP with polyvinylpyrrolidone Plasdone K-29/32 (SDs PVP). FT-IR analysis demonstrated the presence of intermolecular hydrogen bonding between DIP and CoPVP or PVP in SDs. DSC and XRD studies indicated that DIP presented in amorphous state in both SDs CoPVP and SDs PVP at higher weight ratios. The dissolution property of SDs CoPVP was significantly improved in comparison of pure DIP and physical mixtures with CoPVP (PM CoPVP). Both SDs CoPVP and SDs PVP powder showed the favorable flowability. However, SDs CoPVP showed better compressibility than SDs PVP. The lower hydroscopicity of SDs CoPVP could be advantageous to the stability to SDs. This study proves the potential of CoPVP as a carrier in the formulations of SDs for poorly soluble drugs.
authors.affiliation: Department of Pharmaceutics, China Pharmaceutical University, Nanjing, PR China.
authors.forename: Shengjun
authors.initials: S
authors.lastname: Chen
authors.forename: Jiabi
authors.initials: J
authors.lastname: Zhu
authors.forename: Fengqin
authors.initials: F
authors.lastname: Ma
authors.forename: Qun
authors.initials: Q
authors.lastname: Fang
authors.forename: Yinghuan
authors.initials: Y
authors.lastname: Li
mesh_terms: D000085:Acetates; D002152:Calorimetry, Differential Scanning; D004176:Dipyridamole / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers; D008859:Microscopy, Polarization; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000737:chemistry*; D011205:Povidone / Q000031:analogs & derivatives*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000085:Acetates; D004337:Drug Carriers; D010975:Platelet Aggregation Inhibitors; C525248:copolyvidonum Plasdone S-630; D004176:Dipyridamole; D011205:Povidone