A case-control study on excessive daytime sleepiness in episodic migraine.
Migraine patients often complain of sleepiness, a problem that manifests both during and outside an attack, may impair the quality of life and can lead to potentially harmful situations. Findings from an uncontrolled study suggest that a high percentage of migraineurs experience excessive daytime sleepiness (EDS). We investigated EDS in a case-control study on 100 patients with episodic migraine and 100 age- and sex-matched healthy controls and also assessed sleep quality, anxiety and depression. Although it was found that EDS was more frequent in migraineurs than in controls (14% vs. 5%; odds ratio 3.1; 95% confidence interval 1.1-8.9), the frequency was lower than previously reported. EDS correlated with migraine disability, sleep problems and anxiety. EDS in patients with migraine probably stems from the full constellation of headache-sleep-affective symptoms resulting from the complex clinical burden of the disease.
Barbanti
P
P
Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele, Via della Pisana 235, 00163 Rome, Italy. piero.barbanti@sanraffaele.it
Fabbrini
G
G
Aurilia
C
C
Vanacore
N
N
Cruccu
G
G
D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D001007:Anxiety / Q000453:epidemiology; D016022:Case-Control Studies; D003863:Depression / Q000453:epidemiology; D006970:Disorders of Excessive Somnolence / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000150:complications* / Q000517:prevention & control
D018712:Analgesics, Non-Narcotic; D000927:Anticonvulsants