title: Identification of Lynch syndrome: how should we proceed in the 21st century?
abstract: Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer. Although great advances in the understanding of its molecular basis have taken place in the last decade, optimal selection of individuals for HNPCC genetic testing remains controversial. This is especially relevant since colonoscopy has been proven effective for reducing colorectal cancer incidence and mortality in individuals at-risk for this disorder. In this manuscript, we summarize the most significant contributions to this important issue that have appeared in the last few years.
authors.affiliation: Department of Gastroenterology, Hospital Clinic, Villarroel 170, 08036, Barcelona, Catalonia, Spain. castells@clinic.ub.es
authors.forename: Antoni
authors.initials: A
authors.lastname: Castells
authors.forename: Francesc
authors.initials: F
authors.lastname: Balaguer
authors.forename: Sergi
authors.initials: S
authors.lastname: Castellví-Bel
authors.forename: Victòria
authors.initials: V
authors.lastname: Gonzalo
authors.forename: Teresa
authors.initials: T
authors.lastname: Ocaña
mesh_terms: D002986:Clinical Trials as Topic; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D005820:Genetic Testing; D006801:Humans; D018579:Patient Selection