CD8 T cells and latent herpes simplex virus type 1: keeping the peace in sensory ganglia.
Herpes simplex virus type 1 (HSV-1) infections represent a significant worldwide heath problem. The lack of an effective therapy to curtail reactivation of HSV-1 from a state of neuronal latency has lead to significant morbidity and mortality. Effective therapies to prevent reactivation must likely elicit a protective CD8 T-cell response that could act to prevent reactivation from sensory neurons prior to release of infectious virus at the periphery. This review focuses on the present understanding of how CD8 T cells maintain HSV-1 latency and how this knowledge could facilitate the generation of more effective therapeutic modalities.
Sheridan
Brian S
BS
University of Pittsburgh, School of Medicine, Graduate Program in Immunology, 203 Lothrop Street, Pittsburgh, PA 15213, USA.
Knickelbein
Jared E
JE
Hendricks
Robert L
RL
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000821:virology*; D017950:Ganglia, Sensory / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D014775:Virus Activation / Q000276:immunology; D017735:Virus Latency / Q000276:immunology