CD8(+) T cell differentiation: choosing a path through T-bet.
Activated CD8(+) T cells can differentiate into transient effector cells or long-lived memory cells. In this issue of Immunity, Joshi et al. (2007) suggest that inflammatory cytokines dictate this balance by regulating the expression of the transcription factor T-bet.
Hamilton
Sara E
SE
Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55454, USA.
Jameson
Stephen C
SC
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D016207:Cytokines / Q000235:genetics*; D008213:Lymphocyte Activation; D051379:Mice; D020825:T-Box Domain Proteins / Q000378:metabolism*; D000098815:T-bet Transcription Factor
D016207:Cytokines; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor