title: A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55.
abstract: A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A(1) and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of beta-arrestin in HeLa cells at the concentration of 20 microM.
authors.affiliation: Japan Biological Information Research Center (JBIRC), Japan Biological Informatics Consortium (JBIC), Tokyo, Japan. hasumi@cc.tuat.ac.jp
authors.forename: Jun-Ya
authors.initials: JY
authors.lastname: Ueda
authors.forename: Takushi
authors.initials: T
authors.lastname: Togashi
authors.forename: Susumu
authors.initials: S
authors.lastname: Matukura
authors.forename: Aya
authors.initials: A
authors.lastname: Nagai
authors.forename: Takuji
authors.initials: T
authors.lastname: Nakashima
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Komaki
authors.forename: Kozue
authors.initials: K
authors.lastname: Anzai
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Harayama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Doi
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Tohru
authors.initials: T
authors.lastname: Natsume
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Kisu
authors.forename: Naoki
authors.initials: N
authors.lastname: Goshima
authors.forename: Nobuo
authors.initials: N
authors.lastname: Nomura
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-Ya
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D011728:Pyridones / Q000494:pharmacology*; D013057:Spectrum Analysis; D013302:Streptomyces
chemical_list: D000900:Anti-Bacterial Agents; C524347:JBIR-02 compound; D011725:Pyridines; D011728:Pyridones; C100213:piericidin A