title: Repairing large duodenal injuries in dogs by expanded polytetrafluoroethylene patch.
abstract: BACKGROUND
  One of the most challenging problems in clinical surgery is management of injured duodenum. In this experimental study, we treated large duodenal defects by an expanded polytetrafluoroethylene (ePTFE, Gore-Tex; W.L. Gore, Elkton, MD) soft-tissue patch and compared it with the jejunal serosal patch.
  
  
  METHODS
  A duodenal defect (about 50% of the total circumference) was created in the second portion of the duodenum in 20 dogs. The effectiveness and gross and histological examinations of the ePTFE patch technique was compared with the jejunal serosal patch.
  
  
  RESULTS
  No significant difference was found in early survival rates (90.9% versus 88.9%; P = 0.711). The whole grafted area was covered by neomucosa at the end of the sixth week in all animals with the ePTFE patch. The scar was small; no significant narrowing of lumen was noted and serosal healing was uniformly complete. In histological examination, complete coverage of the ePTFE grafts by neomucosa consisting of columnar epithelium with short villous formations was observed.
  
  
  CONCLUSIONS
  Use of the ePTFE patch method is easy, reliable, and comparable to the jejunal serosal patch. It can be used in the treatment of large duodenal defects, which cannot be repaired by duodenorraphy.
authors.affiliation: Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz, Iran. transpln@sums.ac.ir
authors.forename: Saman
authors.initials: S
authors.lastname: Nikeghbalian
authors.forename: Sohrab
authors.initials: S
authors.lastname: Atefi
authors.forename: Kourosh
authors.initials: K
authors.lastname: Kazemi
authors.forename: Hamed
authors.initials: H
authors.lastname: Jalaeian
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Roshan
authors.forename: Naser
authors.initials: N
authors.lastname: Naderi
authors.forename: Reza
authors.initials: R
authors.lastname: Hajizadeh
authors.forename: Nader
authors.initials: N
authors.lastname: Tanideh
mesh_terms: D000818:Animals; D013505:Digestive System Surgical Procedures / Q000379:methods* / Q000401:mortality; D004195:Disease Models, Animal; D004285:Dogs; D004386:Duodenum / Q000293:injuries* / Q000601:surgery*; D007583:Jejunum / Q000601:surgery; D011138:Polytetrafluoroethylene; D012704:Serous Membrane / Q000601:surgery; D013526:Surgical Mesh; D015996:Survival Rate; D014945:Wound Healing
chemical_list: D011138:Polytetrafluoroethylene