Sacroiliitis and polyneuropathy during isotretinoin treatment.
Isotretinoin, a medication for acne, has been reported to cause a variety of side effects on the musculoskeletal system. We present a case of sacroiliitis (a relatively uncommon feature) and sensorimotor demyelinating polyneuropathy, which has been reported previously in only a few cases during isotretinoin therapy. Clinical symptoms were improved after the withdrawal of isotretinoin and the follow-up electrophysiological study performed 2 years after the initial diagnosis of polyneuropathy showed mild improvement. Dermatologists are advised to be alert to symptoms of polyneuropathy and sacroiliitis during treatment with isotretinoin.
Eksioglu
E
E
Department of Neurology, Ministry of Health, Ankara Diskapi Yildirim Beyazit Education Hospital, Ankara, Turkey. emeleksioglu@yahoo.com
Oztekin
F
F
Unlu
E
E
Cakci
A
A
Keyik
B
B
Karadavut
I K
IK
D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D001168:Arthritis / Q000139:chemically induced* / Q000378:metabolism; D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D011115:Polyneuropathies / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D016896:Treatment Outcome; D028761:Withholding Treatment
D003879:Dermatologic Agents; D015474:Isotretinoin