title: Macroglobulin-Producing Plasma-Cell Tumor in Mice: Identification of a New Light Chain.
abstract: A transplantable plasmacell tumor in mice produces both a gammaM-macroglobulin serum protein with a sedimentation coefficient of 17S and a kappa-type urinary protein. The reduced and alkylated macroglobulin, when examined by electrophoresis in acid-urea polyacrylamide gel, had a fast component which migrated in the same position as the urinary protein and also a slow component. These two components, as shown by exclusion chromatography, represent the light and heavy polypeptide chains of the gammaM-macroglobulin. The aforementioned macroglobulin was antigenically related to that in normal mouse serum.
authors.forename: K R
authors.initials: KR
authors.lastname: McIntimif
authors.forename: R M
authors.initials: RM
authors.lastname: Asofsky
authors.forename: M
authors.initials: M
authors.lastname: Potter
authors.forename: E L
authors.initials: EL
authors.lastname: Kuff