title: [Acute retinal necrosis in an acute leukemia pediatric patient].
abstract: Acute retinal necrosis (ARN) is a serious condition that can impair vision. It mostly occurs in adult patients, especially those severely immunocompromised, in association with a reactivation of a herpes virus infection. We present a 4 years old patient with high risk acute leukemia, whom during a course of intense chemotherapy acquired chickenpox with visceral involvement that affected the retina, causing unilateral blindness. Varicella-zoster virus was detected by PCR in the vitreous humor, in spite of previous acyclovir treatment. The contralateral vision remained undamaged.
authors.affiliation: Departamento de Pediatría Oriente, Universidad de Chile, Santiago, Chile. jptorres@med.uchile.cl
authors.forename: Juan P
authors.initials: JP
authors.lastname: Torres T
authors.forename: Emma
authors.initials: E
authors.lastname: Concha V
authors.forename: Juan P
authors.initials: JP
authors.lastname: López G
authors.forename: José
authors.initials: J
authors.lastname: Cofre G
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D002644:Chickenpox / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002675:Child, Preschool; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D015882:Retinal Necrosis Syndrome, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*
chemical_list: D000998:Antiviral Agents