[Comparison of the effect of eight kinds of volatile oil of Chinese material medica on percutaneous absorption of ibuprofen in vitro].
OBJECTIVE
To compare the permeation-enhancing effect of the volatile oil of eight kinds of Chinese material medica including Fructus Evodia, Radix Saposhnikoviae, Rhizoma Atractylodes lancea Radix Aucklandiae, Radix Curcuma wenyujin, Rhizoma et Radix Notopterygii, Lignum Aquilariae Resinatum, Herba Schizonepetae on the model drug of ibuprofen in order to provide theoretic foundation for the selection and application of natural penetration enhancer.


METHODS
The permeation flux of ibuprofen was determined using the penetration experiment apparatus in vitro. The content of ibuprofen was measured by HPLC.


RESULTS
All the above mentioned volatile oil showed permeation enhancing effect on ibuprofen in different degrees, and the enhancive permeation multiple was 3.46, 3.00, 2. 36, 2.32, 2.28, 2.01, 1.37 and 1.29.


CONCLUSIONS
All eight kinds of volatile oil can enhance the percutaneous absorption of ibuprofen in vitro, among which the volatile oil of Fructus Evodia and Radix Saposhnikoviae showed significant penetration enhancing effect.
Luo
Xiao-Qing
XQ
Suzhou Medicinal Technology College, Suzhou 215002, China. lxq7209@163.com
Gu
Yao-Hua
YH
Wu
Zhi-Yuan
ZY
D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D007052:Ibuprofen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; D007052:Ibuprofen