Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in bipolar disorder.
Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. The aim of this study was to examine the association between polymorphisms in CRF-BP gene and bipolar disorder in an isolated Swedish population. One hundred and eighty-two patients with bipolar I disorder and 333 controls from Northern Sweden were included in the study. Five single nucleotide polymorphisms and a deletion polymorphism in the CRF-BP gene were genotyped. The haplotype block structure of the gene was considered and the expectation maximization algorithm was adopted to estimate the haplotype frequencies. As a result, there were no significant associations of the different polymorphisms in the CRF-BP gene with bipolar disorder. In conclusion, this study in an isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder.
Van Den Eede
Filip
F
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Antwerp, Belgium.
Venken
Tine
T
Van Den Bogaert
Ann
A
Del-Favero
Jurgen
J
Norrback
Karl-Fredrik
KF
Nilsson
Lars Göran
LG
Adolfsson
Rolf
R
Van Broeckhoven
Christine
C
Claes
Stephan J
SJ
D000465:Algorithms; D001714:Bipolar Disorder / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D013548:Sweden
D002352:Carrier Proteins; C067133:corticotropin releasing factor-binding protein