Metastatic cancer of the urinary bladder: can it be a nonnatural death?
Deaths from metastatic carcinoma are almost exclusively viewed as wholly natural deaths. However, if it can be shown that a cancer has arisen as a result of a prior traumatic injury and the body's healing response to the injury, or treatment thereof, then in select cases, the manner of death shall reflect that of the precipitating injury. This case report is that of a woman who was rendered quadriplegic from spinal cord injury sustained in a motor vehicle crash when she was 22 years old. She died at the age of 49 years from widely metastatic squamous cell carcinoma of the urinary bladder. Her bladder cancer most likely arose from decades-long chronic irritation of the bladder epithelium by physical contact with an indwelling Foley catheter and urinary infections. Over the years, the chronic bladder irritation likely precipitated metaplastic, dysplastic, and finally neoplastic changes of the bladder epithelium, providing a link between her spinal cord injury, the indwelling Foley catheter, and her bladder cancer, engendering an accidental manner of death. The manner of death reflected the circumstances of her injury that predisposed her to the cancer that eventually caused her death.
Dolinak
David
D
Cuyahoga County Coroner's Office, Cleveland, Ohio 44106, USA. ddolinak@hotmail.com
D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000556:secondary*; D002408:Catheters, Indwelling / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D008875:Middle Aged; D011782:Quadriplegia / Q000150:complications / Q000209:etiology; D013119:Spinal Cord Injuries / Q000150:complications*; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000556:secondary*; D001750:Urinary Bladder, Neurogenic / Q000150:complications / Q000209:etiology; D014546:Urinary Catheterization / Q000009:adverse effects