A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus.
An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.
Rocha
Eleusa Maria F
EM
Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.
Garcia-Effron
Guillermo
G
Park
Steven
S
Perlin
David S
DS
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000235:genetics; D025141:Drug Resistance, Fungal / Q000235:genetics*; D054714:Echinocandins / Q000494:pharmacology*; D005656:Fungal Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors / Q000235:genetics*; D008969:Molecular Sequence Data; D011392:Proline / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D012694:Serine / Q000235:genetics
D054714:Echinocandins; D005656:Fungal Proteins; D012694:Serine; D011392:Proline; D005964:Glucosyltransferases; C040232:glucan synthase