title: MR diffusion - "diffraction" phenomenon in multi-pulse-field-gradient experiments.
abstract: Using pulsed-field-gradient (PFG) experiments, the sizes of the pores in ordered porous media can be estimated from the "diffraction" pattern that the signal attenuation curves exhibit. A different diffraction pattern is observed when the experiment is extended to a larger number (N) of diffusion gradient pulse pairs. Simulations to calculate signal values from arbitrary gradient waveforms are performed for diffusion in restricted geometries using a matrix operator formalism. The simulations suggest that the differences in the characteristics of the attenuation curves are expected to make it possible to measure smaller pore sizes, to improve the accuracy of pore size measurements and potentially to distinguish different pore shapes using the N-PFG technique. Moreover, when an even number of PFG pairs is used, it is possible to observe the diffraction pattern at shorter diffusion times and measure an approximation to the average pore size even when the sample contains pores with a broad distribution of sizes.
authors.affiliation: Section on Tissue Biophysics and Biomimetics, LIMB, NICHD, National Institutes of Health, Bethesda, MD 20892, USA. evren@helix.nih.gov
authors.forename: Evren
authors.initials: E
authors.lastname: Ozarslan
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Basser
mesh_terms: D003198:Computer Simulation; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D016062:Porosity; D012815:Signal Processing, Computer-Assisted