The effects of melatonin on postoperative intraabdominal adhesion formation.
OBJECTIVE
Postoperative intraabdominal adhesion formation is a major clinical problem. No previous study was found, reporting the relationship between adhesion formation and melatonin administration, but melatonin, a strong antioxidant, is recognized to have certain effects on the progression of adhesion formation mechanism. It was therefore decided to investigate the effects of melatonin on postoperative adhesion formation.


METHODS
A total number of 24 Sprague-Dawley rats were utilized. Three groups, described as: Group A, sham laparatomy (n=8), Group B, rats that underwent only ischemia-reperfusion (n=8) and Group C, rats that underwent ischemia- reperfusion and were given 10 mg/kg melatonin solution i.v. (n=8). For Groups B and C, the ileocolic vessels were clamped. Blood glutathione peroxidase levels of all study groups were assessed, then microscopic and macroscopic adhesion scores were evaluated.


RESULTS
Glutathione peroxidase levels of the melatonin-treated group were significantly higher and fibroblast proliferation and macroscopic adhesion scores were significantly lower, than in the melatonin-free group.


CONCLUSIONS
The results of this study supported the hypothesis, that melatonin administration may prevent intraabdominal adhesions resulting from surgery.
Hatipoğlu
Ahmet
A
Department of General Surgery, Trakya University, Medical Faculty, 22030 Edirne, Turkey. turkyilmazz@yahoo.com
Türkyilmaz
Zeliha
Z
Mert
Selva
S
D000005:Abdomen / Q000473:pathology / Q000601:surgery*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D008550:Melatonin / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000188:drug therapy / Q000473:pathology
D000975:Antioxidants; D008550:Melatonin