Islet beta-cell death - fuel to sustain autoimmunity?
Under what context do dying beta-cells enhance the autoimmune process in type 1 diabetes? Kim et al. (2007) find that secondary necrosis of beta-cells can prime the autoimmune response via uptake by and activation of antigen-presenting cells through Toll-like receptor 2.
Filippi
Christophe M
CM
La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. christophe@liai.org
von Herrath
Matthias G
MG
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D017209:Apoptosis; D015551:Autoimmunity / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D050417:Insulin-Secreting Cells / Q000276:immunology / Q000473:pathology*; D051379:Mice; D009336:Necrosis; D051195:Toll-Like Receptor 2 / Q000378:metabolism*
D051195:Toll-Like Receptor 2