Induction of late graft-versus-host disease in a patient post-allogeneic stem cell transplantation by progesterone in conjunction with donor lymphocyte infusion.
Patients after stem cell transplantation (SCT), often develop graft-versus-host disease (GVHD) which, although potentially dangerous, is associated with the beneficial graft-versus-leukemia (GVL) effect. Where there is high risk of disease recurrence, donor lymphocyte infusions (DLI) are given to provide long-term disease control. We present a patient treated with DLI 4 years post-SCT, who developed acute GVHD after administration of progesterone to induce menstruation. This rare allergic reaction warrants further investigation.
Gesundheit
Benjamin
B
Department of Bone Marrow Transplantation, Cancer Immunotherapy & Immunobiology Research Center, Hadassah University Hospital, P.O.B. 12000, Jerusalem 91120, Israel. gesund@hadassah.org.il
Shapira
Michael Y
MY
Maly
Alexander
A
Samuel
Simcha
S
Budowski
Einat
E
Or
Reuven
R
D000328:Adult; D005260:Female; D006086:Graft vs Host Disease / Q000139:chemically induced*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D017710:Lymphocyte Transfusion; D011374:Progesterone / Q000009:adverse effects*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous
D011374:Progesterone