title: No evidence for an association between G protein beta3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia.
abstract: OBJECTIVE
  Tardive dyskinesia (TD) is a long-term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein beta3 subunit (GNB3) gene for association with drug-induced TD in the Korean schizophrenic patients.
  
  
  METHODS
  We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenic patients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables.
  
  
  RESULTS
  The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenic patients with TD and without TD (p > 0.05).
  
  
  CONCLUSIONS
  Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3 825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD.
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Seung-Gul
authors.initials: SG
authors.lastname: Kang
authors.forename: Jong-Woo
authors.initials: JW
authors.lastname: Paik
authors.forename: Moon-Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Bang-Hyun
authors.initials: BH
authors.lastname: Cho
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Park
authors.forename: Won
authors.initials: W
authors.lastname: Kim
authors.forename: Jung-Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: In-Kwa
authors.initials: IK
authors.lastname: Jung
authors.forename: Leen
authors.initials: L
authors.lastname: Kim
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents; C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins