In vivo proton magnetic resonance spectroscopy assessment for muscle metabolism in neuromuscular diseases.
Muscle metabolites were obtained by in vivo proton magnetic resonance spectroscopy of 3 patients with Duchenne muscular dystrophy (DMD), 6 patients with spinal muscular atrophy (SMA), and 10 normal volunteers. Patients with DMD and SMA had lower trimethyl amide (TMA)/water and TMA/total creatine (tCr) ratios but normal tCr/water ratios.
Hsieh
Tsyh-Jyi
TJ
Department of Medical Imaging, Kaohsiung Medical University Hospital, Taiwan.
Wang
Chien-Kuo
CK
Chuang
Hung-Yi
HY
Jong
Yuh-Jyh
YJ
Li
Chun-Wei
CW
Liu
Gin-Chung
GC
D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008744:Methylamines / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D009134:Muscular Atrophy, Spinal / Q000378:metabolism*; D020388:Muscular Dystrophy, Duchenne / Q000378:metabolism*
D008744:Methylamines; C023336:trimethylamine; D003401:Creatine