[Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders--current evidence and preliminary recommendations].
Elevated concentration of total homocysteine (Hcy) in plasma (> 12 micromol/l) is a risk factor for several diseases of the central nervous system. Epidemiological studies have shown a dose-dependent relationship between concentrations of Hcy and the risk for neurodegenerative diseases. Hcy is a marker for B-vitamin deficiency (folate, B12, B6). Hyperhomocysteinemia (HHcy) causes hypomethylation which is an important mechanism that links Hcy to dementia. Supplementation with vitamins B aims at reducing the risk of neurodegenerative diseases. Current evidence suggests that Hcy-lowering treatment has a positive effect for the secondary and primary prevention of stroke. HHcy is very common in patients with Parkinson disease particularly those who receive L-dopa treatment. Furthermore, a positive association has been reported between HHcy and multiple sclerosis. Moreover, HHcy and vitamin B deficiency are reported to have a causal role in depression, and epilepsy. In addition several anti-epileptic drugs cause secondary HHcy. Therefore, sufficient intakes of the vitamins are recommended for patients who have already developed neuropsychiatric diseases. Vitamin B deficiency should be suspected in children with development disorders, failure to thrive and unexplained neurological manifestations. Elderly people are also an important at-risk group where vitamin B deficiency and HHcy have been linked to neurodegenerative diseases. Treatment with folate, B12, and B6 can improve cerebral function. Preventive vitamin B supplementation and sufficient intake seem very important for secondary and primary prevention of neuropsychiatric disorders, especially in subjects with a low intake or status of the vitamins.
Herrmann
W
W
Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum des Saarlandes, Kirrberger Strasse, Gebaude 57, 66421 Homburg. prof.wolfgang.herrmann@uni-klinikum-saarland.de
Lorenzl
S
S
Obeid
R
R
D000368:Aged; D002490:Central Nervous System / Q000378:metabolism; D002648:Child; D019587:Dietary Supplements; D005492:Folic Acid / Q000627:therapeutic use; D006710:Homocysteine / Q000378:metabolism / Q000502:physiology; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood*; D001523:Mental Disorders / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000097:blood / Q000503:physiopathology*; D010300:Parkinson Disease / Q000378:metabolism; D012307:Risk Factors; D014805:Vitamin B 12 / Q000627:therapeutic use; D014804:Vitamin B Deficiency / Q000097:blood*
D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12