title: Which role for pre-treatment laparoscopic staging?
abstract: OBJECTIVE
  To investigate in cervical cancer patients the impact of pre-treatment laparoscopic staging on treatment plan and disease free survival.
  
  
  METHODS
  A review of the present literature has been performed and data have been compared to results obtained in a large series of patients not surgically staged.
  
  
  RESULTS
  Among 134 abstracts resulting from Medline research, 13 were deemed potentially relevant to the study questions. The presence of intraperitoneal diffusion of disease can be recognized in locally advanced cervical cancer patients (LACC) in a percentage ranging between 1.9% and 29%. The rate of aortic positive nodes in clinically negative LACC patients cases has been reported between 11% and 25%, by laparoscopy. In our Division, 152 LACC patients have been treated between October 1997 and February 2007. None of the patients has been submitted to pre-treatment laparoscopic staging, whereas in all cases a pre-operative MRI has been performed. With a median follow-up 28.0 months (range 3-126 months), 31 recurrences have been observed. The 5-year DFS has been 83% and OS 90%. Although only a retrospective analysis can be carried out, such result well compares to cases surgically staged.
  
  
  CONCLUSIONS
  Pre-treatment surgical staging can identify positive nodes in LACC patients considered clinically negative, and recognize intraperitoneal disease, thus making the physician tailor the treatment on the bases of histopathological result. Moreover, it offers the potential advantage of debulking of macroscopically positive nodes, and to transpose the ovary outside the radiation. However, the positive impact on DFS has still to be demonstrated.
authors.affiliation: Division of Gynecologic Oncology, Catholic University of the Sacred Heart, Campobasso, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Fagotti
authors.forename: Francesco
authors.initials: F
authors.lastname: Fanfani
authors.forename: Romina
authors.initials: R
authors.lastname: Longo
authors.forename: Francesco
authors.initials: F
authors.lastname: Legge
authors.forename: Alessandra
authors.initials: A
authors.lastname: Mari
authors.forename: Maria L
authors.initials: ML
authors.lastname: Gagliardi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scambia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery*