Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related Zinc-Finger ZIM proteins.
The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.
Sun
Hongliu
H
Intercollege Graduate Degree Program in Genetics, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Nelms
Brian L
BL
Sleiman
Sama F
SF
Chamberlin
Helen M
HM
Hanna-Rose
Wendy
W
D019943:Amino Acid Substitution; D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000502:physiology; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics; D005786:Gene Expression Regulation; D017238:Genes, Helminth; D014157:Transcription Factors / Q000502:physiology*; D016335:Zinc Fingers
D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; C507738:HIM-8 protein, C elegans; D014157:Transcription Factors; C516318:Zim-1 protein, C elegans; C516319:Zim-2 protein, C elegans; C516320:Zim-3 protein, C elegans