title: Childhood bullous pemphigoid treated by i.v. immunoglobulin.
abstract: Bullous pemphigoid is an acquired autoimmune subepidermal blistering disorder mostly seen in the elderly. Childhood bullous pemphigoid is very rare. For the first time we report a case of childhood bullous pemphigoid associated with infantile eczema. Two weeks after a routine vaccination, a 3.5-month-old boy with infantile eczema developed a generalized blistering disorder. Histopathology revealed a subepidermal blister. Direct immunofluorescence showed linear depositions of C3 along the basement membrane zone. Indirect immunofluorescence studies demonstrated the presence of circulating immunoglobulin G antibodies directed against the epidermal side of salt-split skin. Enzyme-linked immunosorbent assay demonstrated serum level of anti-BP180 antibody elevated. The patient was successfully treated by high-dose i.v. immunoglobulin.
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xiao
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Ya-Kun
authors.initials: YK
authors.lastname: Wang
authors.forename: Chun-Di
authors.initials: CD
authors.lastname: He
authors.forename: Hong-Duo
authors.initials: HD
authors.lastname: Chen
mesh_terms: D001323:Autoantibodies / Q000097:blood; D003876:Dermatitis, Atopic / Q000150:complications; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D007159:Immunologic Tests; D007223:Infant; D008297:Male; D010391:Pemphigoid, Bullous / Q000150:complications / Q000473:pathology / Q000628:therapy*; D012867:Skin / Q000276:immunology / Q000473:pathology*
chemical_list: D001323:Autoantibodies; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors