title: Association between HLA class II alleles and autoimmune hepatitis type 1 in Thai patients.
abstract: OBJECTIVE
  To investigate the association between HLA class II alleles and autoimmune hepatitis (AIH) type I in Thai patients.
  
  
  METHODS
  The clinical data of 50 autoimmune hepatitis patients type I (AIH) at Siriraj hepatitis clinic were analysed, 37 of whom were tested for HLA class II genotyping using polymerase chain reaction and sequence-specific oligonucleotide technique (PCR-SSO).
  
  
  RESULTS
  AIH is an uncommon chronic hepatitis in Thailand with females predominant. The HLA DRB1*0301, and DQA1*0101 were significantly associated with AIH patients when compared to controls; (OR = 3.92 [1.18-13.30], p 0.021, OR = 2.31 [1.13-4.73], p 0.019, respectively). When 18 patients with "definite" AIH were analysed, only HLA DRB1*0301 was still significantly associated with AIH (OR = 5.22, 95%CI = 1.28-20.92, p 0.015).
  
  
  CONCLUSIONS
  HLA genotyping has shown that HLA DRB1*0301 and HLA DQA1*0101 were significantly associated with AIH.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand. sittw@mahidol.ac.th
authors.forename: Tawesak
authors.initials: T
authors.lastname: Tanwandee
authors.forename: Sutep
authors.initials: S
authors.lastname: Wanichapol
authors.forename: Sasijit
authors.initials: S
authors.lastname: Vejbaesya
authors.forename: Sivaporn
authors.initials: S
authors.lastname: Chainuvati
authors.forename: Watcharasak
authors.initials: W
authors.lastname: Chotiyaputta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000235:genetics; D016021:Epidemiologic Studies; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D019693:Hepatitis, Autoimmune / Q000453:epidemiology / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology
chemical_list: D006680:HLA Antigens; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553502:HLA-DRB1*03:01 antigen; D000949:Histocompatibility Antigens Class II