Dendrimers as drug carriers: applications in different routes of drug administration.
Dendrimers have successfully proved themselves as useful additives in different routes of drug administration because they can render drugs greater water-solubility, bioavailability, and biocompatibility. This review demonstrated the potential of dendrimers to be applied in these detailed routes with particular reference to intravenous, oral, transdermal, and ocular delivery systems. As a necessary introduction, the structures, synthesis, and properties of dendrimers were presented. Furthermore, the interaction mechanisms between dendrimers and drug molecules, including simple encapsulation, electrostatic interaction, and covalent conjugation, were elaborated.
Cheng
Yiyun
Y
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. yycheng@mail.ustc.edu.cn
Xu
Zhenhua
Z
Ma
Minglu
M
Xu
Tongwen
T
D000818:Animals; D050091:Dendrimers / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry*; D004339:Drug Compounding; D004563:Electrochemistry; D006801:Humans; D053758:Nanoparticles; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012995:Solubility; D013329:Structure-Activity Relationship
D050091:Dendrimers; D004337:Drug Carriers; D004364:Pharmaceutical Preparations