title: Role of superantigenic strains in the prognosis of community-acquired methicillin-susceptible Staphylococcus aureus bacteraemia.
abstract: Methicillin-susceptible Staphylococcus aureus (MSSA) strains can produce superantigenic toxins that may trigger a massive release of pro-inflammatory cytokines, which are involved in the onset of septic shock. This 1-year prospective pilot study assessed the role of the production of superantigenic toxins in the outcome of immunocompetent patients hospitalised for community-acquired MSSA bacteraemia. Thirty-seven patients were enrolled, of whom 14 died in hospital. Fourteen patients had septic shock, and the mortality rate in this subgroup was 56%. Twenty-seven (73%) isolates produced at least one superantigenic toxin, but this did not influence the rate of occurrence of septic shock or death.
authors.affiliation: Dupuytren Teaching Hospital, Medical-Surgical Intensive Care Unit, Limoges, France. arnaud.desachy@ch-angouleme.fr
authors.forename: A
authors.initials: A
authors.lastname: Desachy
authors.forename: G
authors.initials: G
authors.lastname: Lina
authors.forename: P
authors.initials: P
authors.lastname: Vignon
authors.forename: A
authors.initials: A
authors.lastname: Hashemzadeh
authors.forename: F
authors.initials: F
authors.lastname: Denis
authors.forename: J
authors.initials: J
authors.lastname: Etienne
authors.forename: B
authors.initials: B
authors.lastname: Francois
authors.forename: M C
authors.initials: MC
authors.lastname: Ploy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D004768:Enterotoxins / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008712:Methicillin / Q000627:therapeutic use*; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012772:Shock, Septic / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000276:immunology* / Q000302:isolation & purification; D018089:Superantigens / Q000276:immunology*
chemical_list: D000900:Anti-Bacterial Agents; D004768:Enterotoxins; D018089:Superantigens; D008712:Methicillin