title: Risk factors for pathologic gambling and other compulsions among Parkinson's disease patients taking dopamine agonists.
abstract: Three hundred patients with Parkinson's disease taking dopamine agonists were surveyed for the presence of compulsions. Fifty-eight reported active compulsions which had developed after initiation of dopamine agonists. These included 25 with sexual compulsions and 28 with self-described compulsive gambling, of whom 17 met criteria for pathologic gambling. Males were over-represented. Patients with any compulsion and those with pathologic gambling were about 6 years younger than those without compulsions. These behavioral problems were not associated with an individual dopamine agonist, nor dose or duration, nor concomitant levodopa. Follow-up of the pathologic gamblers 1 year after intervention, which was cessation of the dopamine agonist in most cases, found ongoing but controlled gambling in five and complete cessation within 4 months in the remainder.
authors.affiliation: Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USA.
authors.forename: Asha
authors.initials: A
authors.lastname: Singh
authors.forename: Geetha
authors.initials: G
authors.lastname: Kandimala
authors.forename: Richard B
authors.initials: RB
authors.lastname: Dewey
authors.forename: Padraig
authors.initials: P
authors.lastname: O'Suilleabhain
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003192:Compulsive Behavior / Q000209:etiology* / Q000523:psychology*; D003625:Data Collection; D018491:Dopamine Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005715:Gambling / Q000523:psychology*; D006801:Humans; D007989:Libido / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012725:Sexual Behavior / Q000187:drug effects
chemical_list: D000978:Antiparkinson Agents; D018491:Dopamine Agonists