title: Chemical pollution, respiratory allergy and asthma: a perspective.
abstract: The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) convened a workshop in June 2005 to address the speculation that exposure to specific chemicals, and/or chemical pollutants in general, may play an important role in the increased prevalence of allergy and asthma in 'westernized' societies. This paper summarises one perspective arrived at during this workshop. It was acknowledged that certain chemicals and certain types of pollution might trigger or exacerbate asthmatic reactions in sensitised subjects. However, overall levels of pollution appear not to have had a major impact upon the prevalence of atopic allergy. Epidemiological studies suggest that pollution may in some circumstances protect from acquisition of sensitisation. Increasing exposure to household chemicals may enhance pre-existing allergies, but evidence for their causation of allergy is lacking. Other risk factors considered included societal dietary changes and exposure to endotoxins. Future research needs were identified which included epidemiological studies employing exposure and biomonitoring data, studies on domestic exposure to chemicals and their association with the incidence of allergy and asthma, and prospective birth cohort studies employing well-defined aspects of lifestyle, diet, chemical and endotoxin exposure as factors that may drive susceptibility to allergy and asthma.
authors.affiliation: Health and Safety Laboratory, Buxton, Derbyshire SH17 9JN, UK.
authors.forename: Gareth S
authors.initials: GS
authors.lastname: Evans
authors.forename: David
authors.initials: D
authors.lastname: Cadogan
authors.forename: Andreas
authors.initials: A
authors.lastname: Flueckiger
authors.forename: Christa
authors.initials: C
authors.lastname: Hennes
authors.forename: Ian
authors.initials: I
authors.lastname: Kimber
mesh_terms: D004032:Diet; D064420:Drug-Related Side Effects and Adverse Reactions; D004731:Endotoxins / Q000009:adverse effects; D004781:Environmental Exposure / Q000009:adverse effects*; D004787:Environmental Pollution / Q000009:adverse effects*; D006795:Household Products / Q000009:adverse effects; D006801:Humans; D012130:Respiratory Hypersensitivity / Q000453:epidemiology / Q000209:etiology*
chemical_list: D004731:Endotoxins