title: Analysis of blood flow and glucose metabolism in mammary carcinomas and normal breast: a H2(15)O PET and 18F-FDG PET study.
abstract: OBJECTIVE
  To determine parameters of perfusion, distribution coefficient, and glucose metabolism as part of the tumour-specific micromilieu of breast cancer and compare them with corresponding values in normal breast tissue.
  
  
  METHODS
  H2(15)O PET and 18F-FDG PET were performed on 10 patients with advanced invasive ductal carcinomas of the breast. Perfusion, distribution coefficient, and glucose metabolism and standardized uptake were quantified and analysed.
  
  
  RESULTS
  Mean values based on the regions of interest were 59.2+/-43.9 ml x min(-1) x 100 g(-1) (perfusion), 0.58+/-0.26 ml x g(-1) (distribution coefficient), 7.76+/-6.10 (standardized uptake), and 5.4+/-2.5 mg x min(-1) x 100 g(-1) (glucose metabolism). The corresponding values for normal breast tissue were 22.1+/-13.2 ml x min x 100 g(-1) (perfusion), 0.16+/-0.05 ml x g(-1) (distribution coefficient), 0.33+/-0.07 (standardized uptake), and 0.18+/-0.08 mg x min x 100 g(-1) (glucose metabolism). For each tumour-normal tissue parameter pair, the mean values were significantly higher in tumours than normal breast tissue. Region-of-interest and pixel-wise correlation analysis revealed a positive association between glucose metabolism and distribution coefficient and glucose metabolism and perfusion for 7/10 tumours investigated.
  
  
  CONCLUSIONS
  H2(15)O PET and 18F-FDG PET were able to differentiate breast cancer and normal breast tissue. The pixel-wise analysis revealed information about the heterogeneity of tumour fine structure in perfusion, distribution coefficient, and glucose metabolism, which may provide important guidelines for improving individual treatment.
authors.affiliation: Division of Nuclear Medicine and PET Center, University Hospital of Freiburg, Germany. michael.hentschel@uniklinik-freiburg.de
authors.forename: Michael
authors.initials: M
authors.lastname: Hentschel
authors.forename: Timo
authors.initials: T
authors.lastname: Paulus
authors.forename: Michael
authors.initials: M
authors.lastname: Mix
authors.forename: Ernst
authors.initials: E
authors.lastname: Moser
authors.forename: Egbert U
authors.initials: EU
authors.lastname: Nitzsche
authors.forename: Ingo
authors.initials: I
authors.lastname: Brink
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D001943:Breast Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010104:Oxygen Radioisotopes / Q000493:pharmacokinetics*; D049268:Positron-Emission Tomography / Q000379:methods*; D014018:Tissue Distribution; D014867:Water / Q000378:metabolism
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water; D019788:Fluorodeoxyglucose F18; D005947:Glucose