[Study on the technological process of extraction and clathration for Rhizoma Atractylodis Macrocephalae oil with beta-cyclodextrin].
OBJECTIVE
To study the optimal extraction and clathration technology of Rhizoma Atractylodis Macrocephalae oil in Heweilichang Pill.


METHODS
Orthogonal test was employed for selecting the optimum of extraction technology of Rhizoma Atractylodis Macrocephalae oil and the oil extraction rate were used as a index. The optimum including technology was chosen by determining the oil-bearing rate and extract ratio of inclusion compound. The inclusion compound were identified with thin chromatogram.


RESULTS
The extraction technology was 10 volumes of water, extracted 6h with thick granula of Rhizoma Atractylodis Macrocephalae. The optimum preparation conditions for clathrate were established as beta-CD: oil was 6: 1, 3. 5 times of water, triturated for 75 minutes.


CONCLUSIONS
The process is feasible and the method can be used for production.
Huang
Jiang-Hong
JH
Second Clinical Medical College of Guangzhou University of TCM, Guangzhou 510120, China.
D000704:Analysis of Variance; D002855:Chromatography, Thin Layer; D004338:Drug Combinations; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification; D009822:Oils, Volatile / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; D047392:beta-Cyclodextrins