Evaluation of a resistance-based model for the quantification of pulmonary arterial hypertension using MR flow measurements.
OBJECTIVE
To establish an estimate for the mean pulmonary arterial pressure (mPAP) derived from noninvasive data acquired with magnetic resonance (MR) velocity-encoded sequences.


METHODS
In seven sedated pigs synchronous catheter-based invasive pressure measurements (IPM) and noninvasive MR were acquired in the main pulmonary artery (MPA) at different severities of pulmonary arterial hypertension (PAH) that were caused by infusion of thromboxane A2 (TxA2). The invasively measured mPAP was correlated with the noninvasive MR velocity data and linear combination equations (LCE) were computed.


RESULTS
Intravenously applied TxA2 induced a dose dependent level of severity of PAH with an mPAP of up to 54 mmHg without systemic effects. The acceleration time (AT) measured with MR demonstrated the best correlation with the mPAP (r(2) = 0.75). The LCE with the highest correlation (R = 0.945, alpha < 0.01) between IPM and MR revealed a mean difference of 0, a SD of s = 4.66 and a maximal difference of 12.2 mmHg using the Bland-Altman analysis.


CONCLUSIONS
Applying the identified LCE allowed the estimation of the mPAP in an acute and resistance-based model of PAH with high accuracy using noninvasive MR velocity-encoded sequences.
Abolmaali
Nasreddin
N
OncoRay-Molecular Imaging, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. Nasreddin.Abolmaali@OncoRay.de
Seitz
Uwe
U
Esmaeili
Anoosh
A
Kock
Martin
M
Radeloff
Daniel
D
Ackermann
Hanns
H
Vogl
Thomas J
TJ
D000208:Acute Disease; D000818:Animals; D001783:Blood Flow Velocity; D002404:Catheterization; D005069:Evaluation Studies as Topic; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000473:pathology; D007262:Infusions, Intravenous; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011312:Pressure; D011651:Pulmonary Artery / Q000473:pathology; D011652:Pulmonary Circulation; D013552:Swine; D013928:Thromboxane A2 / Q000494:pharmacology
D013928:Thromboxane A2