Cancer chemotherapy II: atypical hepatic injuries.
Although chemotherapy generally is accompanied by regular testing for liver enzyme abnormalities, atypical reactions may occur that escape ordinary detection, because hepatocyte injury is not the primary event. The presence of fatty liver, mitochondrial changes, and even biliary abnormalities can be associated with normal or nearly normal liver enzyme levels. This article discusses unique aspects of liver damage associated with cancer chemotherapy. These unique reactions merit special attention and a special vigilance from clinicians.
Rodriguez-Frias
Edmundo A
EA
Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Lee
William M
WM
D000970:Antineoplastic Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D002779:Cholestasis / Q000139:chemically induced; D005234:Fatty Liver / Q000139:chemically induced; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced; D006801:Humans; D008103:Liver Cirrhosis / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D014775:Virus Activation / Q000187:drug effects
D000970:Antineoplastic Agents