[The in vitro antiviral activity against the causative agent of hemorrhagic fever with renal syndrome].
It is shown that primary screening of drugs against the pathogens of hemorrhagic fever with renal syndrome (HFV) may be performed, by using two approaches in estimating the suppression of plague formation and that of viral reproduction in the cultured cells. It is expedient to make a primary screening of interferon and its inductors to estimate the suppression of viral reproduction in the cultured Vero E6, PSEV, and CL-17 cells, the infection multiplicity should be hundredth parts of BOE/cell. Among the test agents, there are virazole and realdiron that are the most active drugs against Hantaan virus, 76-118 strain, which virually completely suppress the reproduction of the study causative agent, when used even at concentrations of 1-5 microg/ml and 100 U/ml, respectively.
Loginova
S Ia
SIa
Borisevich
S V
SV
Koval'chuk
A V
AV
Shtabnaia
V V
VV
Pashchenko
Iu I
IuI
Khamitov
R A
RA
Maksimov
V A
VA
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D018063:Hantaan virus / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology; D051379:Mice; D009930:Organic Chemicals / Q000494:pharmacology; D013552:Swine; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D007369:Interferon Inducers; D009930:Organic Chemicals; C066530:larifan; D007372:Interferons