title: Proteomics in cancer research: methods and application of array-based protein profiling technologies.
abstract: With the human genome sequence now determined, the field of molecular medicine is moving beyond genomics to proteomics, the large-scale analysis of proteins. It is now possible to examine the expression of more than 1000 proteins using mass spectrometry technology coupled with various separation methods. Microarray technology is a new and efficient approach, for extracting relevant biomedical data and has a wide range of applications. It provides a versatile tool to study protein-protein, protein-nucleic acid, protein-lipid, enzyme-substrate and protein-drug interactions. This review paper will explore the key themes in proteomics and their application in clinical cancer research.
authors.affiliation: Laboratory Experimental Oncology, Catholic University Leuven, Herestraat 49, 3000 Leuven, Belgium. ann.hoeben@uz.kuleuven.ac.be
authors.forename: Ann
authors.initials: A
authors.lastname: Hoeben
authors.forename: Bart
authors.initials: B
authors.lastname: Landuyt
authors.forename: Gehan
authors.initials: G
authors.lastname: Botrus
authors.forename: Gert
authors.initials: G
authors.lastname: De Boeck
authors.forename: Gunther
authors.initials: G
authors.lastname: Guetens
authors.forename: Martin
authors.initials: M
authors.lastname: Highly
authors.forename: Allan T
authors.initials: AT
authors.lastname: van Oosterom
authors.forename: Ernst A
authors.initials: EA
authors.lastname: de Bruijn