Palladium-catalyzed copper(I)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling.
The application of a palladium-catalyzed Cu(I)-mediated Liebeskind-Srogl protocol for the decoration of the 2(1H)-pyrazinone scaffold resulted in significantly improved yields and rates when performed under microwave irradiation with simultaneous cooling.
Singh
Brajendra Kumar
BK
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001, Heverlee/Leuven, Belgium.
Mehta
Vaibhav Pravinchandra
VP
Parmar
Virinder Singh
VS
Van der Eycken
Erik
E
D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D003080:Cold Temperature; D003300:Copper / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D010165:Palladium / Q000737:chemistry*; D011719:Pyrazines / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D001897:Boronic Acids; D011719:Pyrazines; D010165:Palladium; D003300:Copper