Alcohol binging causes peliosis hepatis during azathioprine therapy in Crohn's disease.
Patients with inflammatory bowel disease have normal life expectancy and, due to modern immunosuppressive therapies, also a normal quality of life. Since mostly young people are affected, their social behaviour suits this environment. Alcohol binging is an increasingly disturbing factor among young people. We describe a patient with Crohn's disease, treated with azathioprine, who developed peliosis hepatis after three epsiodes of alcohol binging. Liver toxicity was not observed previously during the course of the treatment. Azathioprine-induced peliosis hepatis is thought to be idiosyncratic in humans. From animal studies, however, it is clear that hepatic depletion of glutathione leads to azathioprine toxicity to the sinusoidal endothelial cells. Damage of these cells causes peliosis hepatis. Since alcohol binging leads to hepatic glutathione depletion, we conclude that in our patient the episodes of binging have reduced liver gluathione content and therefore this has increased azathioprine toxicity causing peliosis hepatis. The problem of alcohol binging has not yet been addressed in IBD patients undertaking immunosuppressive therapy. This should be reviewed in future considerations regarding patients advice.
Elsing
Christoph
C
Department of Gastroenterology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany.
Placke
Joerg
J
Herrmann
Thomas
T
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects*; D002492:Central Nervous System Depressants / Q000009:adverse effects*; D003424:Crohn Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000431:Ethanol / Q000009:adverse effects*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D010382:Peliosis Hepatis / Q000139:chemically induced* / Q000378:metabolism
D002492:Central Nervous System Depressants; D007166:Immunosuppressive Agents; D000431:Ethanol; D005978:Glutathione; D001379:Azathioprine