title: Radioimmunoguided surgery (RIGS), PET/CT image-guided surgery, and fluorescence image-guided surgery: past, present, and future.
abstract: (125)I-labeled anti-TAG-72 antibodies were applied in radioimmunoguided surgery (RIGS) to remove gross and occult tumors. It is challenging to handle (125)I-labeled materials. PET/CT image-guided surgery utilizes (18)FDG to monitor the biochemical activity of the tumor and to integrate pre- and postoperative imaging for complete tumor removal. PET/CT image-guided surgery only detects later stage disease. Fluorescence image-guided surgery using anti-TAG-72 antibodies may provide opportunities for intraoperative cancer detection of both gross and occult tumors.
authors.affiliation: Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Duxin
authors.initials: D
authors.lastname: Sun
authors.forename: Mark
authors.initials: M
authors.lastname: Bloomston
authors.forename: George
authors.initials: G
authors.lastname: Hinkle
authors.forename: Osama Habib
authors.initials: OH
authors.lastname: Al-Saif
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Hall
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Povoski
authors.forename: Mark W
authors.initials: MW
authors.lastname: Arnold
authors.forename: Edward W
authors.initials: EW
authors.lastname: Martin
mesh_terms: D000911:Antibodies, Monoclonal / Q000187:drug effects; D000912:Antibodies, Neoplasm / Q000187:drug effects; D000951:Antigens, Neoplasm / Q000276:immunology; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D005453:Fluorescence; D019788:Fluorodeoxyglucose F18; D005544:Forecasting; D015902:Gamma Cameras; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007457:Iodine Radioisotopes; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D016719:Radioimmunodetection / Q000639:trends; D019275:Radiopharmaceuticals; D025321:Surgery, Computer-Assisted / Q000639:trends; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; C091202:B72.3 antibody; D006023:Glycoproteins; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; C047052:tumor-associated antigen 72; D019788:Fluorodeoxyglucose F18