title: [Relationship between the biological behavior of nasal cavity or sinonasal inverted papilloma and infection of human papillomavirus].
abstract: OBJECTIVE
  To investigate the relationship between the prognosis of nasal inverted papilloma (NIP) and infection of human papillomavirus (HPV).
  
  
  METHODS
  The paraffin-embedded tissue slides of 67 cases of NIP in nasal cavity or paranasal sinuses and of 10 cases of benign nasal polyps (as controls) underwent HE staining and in hybridization in situ (HIS) to detect the expression of 28 types of HPV and positive sites thereof. The 67 NIP patients, 45 males and 12 females, with the onset age of 55.7 (36 - 84), were divided into 3 groups according to the data of follow-up: non-recurrence group (n = 33, Group 1), recurrence group (n = 27, Group 2), and NIP with squamous cell carcinoma (n = 7, Group 3).
  
  
  RESULTS
  The total HPV infection rate of the NIP slides was 49.25%, significantly higher than that of the control group (10%). The infection rates of HPV, especially the infection rates of HPV of the type 16/18, were significantly higher in Groups 2 and 3 than in Group 1. The infection rate of HPV of the type 16/18 was significantly higher in Group 3 than in other groups (all P < 0.01). The infected cells were located in the surface or upper part of the epithelial cell layer in Group 1, and in all parts of the epithelial cell layer in Group 3.
  
  
  CONCLUSIONS
  the recurrence and malignant transition of NIP are related to HPV infection which may be attributed to the wider range of infected cells in these cases. The higher infection rate of high risk HPV type is one of the reasons for malignant transition.
authors.affiliation: Department of Pathology, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Shan-shan
authors.initials: SS
authors.lastname: Lu
authors.forename: Ji-wei
authors.initials: JW
authors.lastname: Xu
authors.forename: Ka-te
authors.initials: KT
authors.lastname: Huang
authors.forename: Qian-he
authors.initials: QH
authors.lastname: Liao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D052685:Alphapapillomavirus / Q000145:classification / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000473:pathology* / Q000821:virology; D018308:Papilloma, Inverted / Q000473:pathology* / Q000821:virology; D030361:Papillomavirus Infections / Q000473:pathology* / Q000821:virology; D010255:Paranasal Sinus Neoplasms / Q000473:pathology* / Q000821:virology