[Medication to treat fibromyalgia?].
The present therapeutic approach is aimed at controlling central sensitisation that is supposed to be the core of fibromyalgia's physiopathological mechanisms. The tricyclic antidepressants have some effects on sleep and the improvement of physical activities. Encouraging results have been observed with the serotonin and noradrenaline reuptake inhibitors such as venlafaxine, milnacipran or duloxetine. New Dopamine D3 receptor agonists as well as the new anticonvulsivants such as gabapentine and pregabalin are equally promising. However the prescription of any medication should take place within a multidisciplinary approach.
Perrot
Serge
S
Service de médecine interne et consultation de la douleur, Hôtel Dieu, 75004 Paris, France. serge.perrot@htd.aphp.fr
D018759:Adrenergic Uptake Inhibitors / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D005356:Fibromyalgia / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D009043:Motor Activity / Q000187:drug effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012890:Sleep / Q000187:drug effects
D018759:Adrenergic Uptake Inhibitors; D000700:Analgesics; D000927:Anticonvulsants; D000929:Antidepressive Agents, Tricyclic; D017367:Selective Serotonin Reuptake Inhibitors