title: Bariatric surgery in the treatment of obstructive sleep apnea in morbidly obese patients.
abstract: BACKGROUND
  Weight loss has been shown effective in the treatment of the obstructive sleep apnea-hypopnea syndrome. Regrettably, many obese patients are unable to achieve sustained and useful weight loss by dietary means. Recently, bariatric surgery has emerged as an alternative to treat obesity and many of its comorbidities, although its role for sleep apnea treatment is still not defined.
  
  
  OBJECTIVE
  To evaluate the impact of bariatric surgery on obstructive sleep apnea in morbidly obese patients.
  
  
  METHODS
  In this cohort study, polysomnography, Epworth Sleepiness Scale questionnaire and clinical assessment were performed in 12 of 13 morbidly obese patients with moderate to severe obstructive sleep apnea treated with bariatric surgery through Roux-en-Y gastric bypass procedure after a minimum of 18 months post surgery.
  
  
  RESULTS
  The mean (+/-SD) loss of excess body weight was 70.5 +/- 24%. The mean level obtained in the Epworth Scale was 4.8. There was a significant reduction in the apnea-hypopnea index, from a median of 46.5 (range: 33-140) to 16 (range: 0.9-87) events per hour (p < 0.05), an improvement in mean oxygen saturation from 85.7 +/- 5.1 to 94.5 +/- 3.6% (p < 0.05) and in minimum oxygen saturation from 64.7 +/- 13.4 to 78.7 +/- 13.7% (p < 0.05). The magnitude of the weight loss and the improvements in mean and minimum oxygen saturation were positively correlated, (r = 0.76; p <or= 0.05, and r = 0.59; p <or= 0.05, respectively).
  
  
  CONCLUSIONS
  Weight loss achieved by bariatric surgery is associated with significant long-term improvements in obstructive respiratory event, oxygenation and resolution of daytime somnolence.
authors.affiliation: Department of Medicine, Division of Respirology, University of Toronto, Toronto, Ontario, Canada. leandro.fritscher@uhn.on.ca
authors.forename: Leandro G
authors.initials: LG
authors.lastname: Fritscher
authors.forename: Simone
authors.initials: S
authors.lastname: Canani
authors.forename: Cláudio C
authors.initials: CC
authors.lastname: Mottin
authors.forename: Carlos C
authors.initials: CC
authors.lastname: Fritscher
authors.forename: Diovane
authors.initials: D
authors.lastname: Berleze
authors.forename: Kenneth
authors.initials: K
authors.lastname: Chapman
authors.forename: José M
authors.initials: JM
authors.lastname: Chatkin
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000150:complications* / Q000601:surgery*; D010100:Oxygen / Q000378:metabolism; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000601:surgery*; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D010100:Oxygen