title: [Influence of enalapryl on vasomotor reactions of rats with chronic deficiency of dopamine in the mesencephalo-striatal system].
abstract: The results of experiments on isolated preparations of aorta and portal vein of rats with chronic deficiency of mesencephalo-striatal dopamine have shown that endothelium-dependent reactions of dilatation were inhibited. If rats with dopamine deficiency received enalapryl (20 mg/kg) these reactions partly recovered. A possible conclusion may be that in conditions of cerebral dopamine deficiency the functional state of endothelium got worse, and endothelium-dependent dilatation of vascular smooth muscles was inhibited. The use of inhibitor of angiotensin-converting enzyme enalapryl resulted in a significant restoration of the above vascular reactions.
authors.forename: S O
authors.initials: SO
authors.lastname: Talanov
authors.forename: M M
authors.initials: MM
authors.lastname: Tkachenko
authors.forename: O V
authors.initials: OV
authors.lastname: Baziliuk
authors.forename: L H
authors.initials: LH
authors.lastname: Stepanenko
authors.forename: V F
authors.initials: VF
authors.lastname: Sahach
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D003342:Corpus Striatum / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000172:deficiency*; D004656:Enalapril / Q000494:pharmacology*; D066298:In Vitro Techniques; D008636:Mesencephalon / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D020734:Parkinsonian Disorders / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D011921:Rats, Inbred WKY; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D014662:Vasoconstrictor Agents; D004656:Enalapril; D004298:Dopamine; D009638:Norepinephrine