title: Refractory psychotic symptoms in a patient with homozygous sickle cell disease: a 24-month follow-up.
abstract: The present report describes a case of a 33-year old male patient with homozygous sickle cell disease (SCD) with comorbid psychotic symptoms. The systematical evaluation revealed an intimate association between acute SCD complications, associated with hematological abnormalities, and psychotic symptoms worsening. Clozapine was effective in controlling psychotic symptoms refractory to previous antipsychotic trials.
authors.affiliation: Department & Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. pedrodealvarenga@gmail.com
authors.forename: Pedro
authors.initials: P
authors.lastname: Gomes de Alvarenga
authors.forename: Marcus Vinicius
authors.initials: MV
authors.lastname: Zanetti
authors.forename: Hélio
authors.initials: H
authors.lastname: Elkis
mesh_terms: D000328:Adult; D001741:Black or African American; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003024:Clozapine / Q000627:therapeutic use; D005500:Follow-Up Studies; D006720:Homozygote; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011618:Psychotic Disorders / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine