Searching for genes influencing a complex disease: the case of coeliac disease.
Recently, a few genes have been reported to be causative in inflammatory diseases. Still, we are waiting for the vast majority to be discovered. New tools for genotyping and statistical analysis have been developed and emphasis has been put on study design. Coeliac disease (CD) is a disorder, where prolamins in dietary wheat gluten and related proteins from rye or barley are not tolerated. It is one of the most common chronic diseases in humans exceeding a population prevalence of 1%. In this article, we will summarise what is currently known about the genetics influencing CD with the emphasis on the non-HLA genetic component. We will discuss some difficulties when searching for susceptibility genes in disorders with complex inheritance patterns.
Naluai
Asa Torinsson
AT
Department of Genomics, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden. asa@genomics.sahlgrenska.gu.se
Ascher
Henry
H
Nilsson
Staffan
S
Wahlström
Jan
J
D005075:Biological Evolution; D002446:Celiac Disease / Q000453:epidemiology / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D010641:Phenotype