[Persistent forms of cow's milk allergy. Report of 6 cases].
BACKGROUND
Cow's milk allergy is defined as reproducible adverse reaction to a food protein antigen which is immune medieted. About 80 to 90 % become clinically tolerated within the first three year of live. The aim of this study is to evaluate the clinical, immunological and evolutive characteristics of the 10 % to 20 % of persistent form of cow's milk allergy.


METHODS
This study included six persistent form of cow's milk allergy (2 boys and 4 girls). The provocation challenge test according to Rance recommendation, have been made from 6 months to one year.


RESULTS
4/6 infants with persistent cow's milk allergy have an atopic familial disease. Clinical presentation changed over time at once symptoms were preventely gastrointestinal, at the end there was an increased frequency of atopic disease (asthma: 4/6 infants)


CONCLUSIONS
Persistent form of cow's milk allergy are characterized by considerable importance of familial atopic disease; change in cow's milk allergy manifestations over time and more prolonged delay between cow's milk persistent consumption and manifestations of symptoms.
Ben Halima
Nabil
N
Service de Pédiatrie, CHU Hédi Choker, Sfax, Tunisie.
Krichen
Anas
A
Mekki
Mohamed Ali
MA
Ben
Mansour Lamia
ML
Chabchoub
Imene
I
Chaabouni
Melek
M
Triki
Ali
A
Karray
Abderrahmen
A
D000818:Animals; D001249:Asthma / Q000150:complications; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008892:Milk / Q000009:adverse effects*; D016269:Milk Hypersensitivity / Q000150:complications* / Q000276:immunology; D012882:Skin Tests
D007073:Immunoglobulin E