title: Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition.
abstract: Increased concentrations of insulin, glucose and glycohemoglobin are associated with Type II diabetes mellitus (DM) and recognized as characteristic markers of the disease; in Alzheimer's (AD), Vascular dementia (VaD), and both dementia's with superimposed diabetes (AD + DM, VaD + DM) the knowledge is scarce. The sample (n = 122; males = 60; mean age = 73 +/- 7) comprised DM, AD, VaD, AD + DM, and VaD + DM patients, and healthy controls (C). The ANOVA's yielded significant differences between groups: Insulin p = 3.7 x 10(-3); Glucose p < 10(-12); Glycohemoglobin p = 9.2x10(-4). Comparisons between groups (DM vs. C, AD + DM vs. AD, VaD + DM vs. VaD, and demented DM vs. non-demented DM) resulted significant for all variables (Bonferroni's statistic, alpha = 0.05). Diabetic and diabetic demented patients presented significant increases largely different from controls (0.01 < p < 0.001), unlike the non-significant changes in their non-diabetic counterparts; linear relationships were found across all groups. The correlation's insulin/glucose and insulin/glycohemoglobin change to positive within demented groups, indicating a different performance of insulin in demented and non-demented subjects.
authors.affiliation: Facultad de Medicina, Hospital Sirio-Libanés, UBA, FACENE, Buenos Aires, Argentina.
authors.forename: R O
authors.initials: RO
authors.lastname: Domínguez
authors.forename: E R
authors.initials: ER
authors.lastname: Marschoff
authors.forename: E M
authors.initials: EM
authors.lastname: Guareschi
authors.forename: M G
authors.initials: MG
authors.lastname: Repetto
authors.forename: A L
authors.initials: AL
authors.lastname: Famulari
authors.forename: M A
authors.initials: MA
authors.lastname: Pagano
authors.forename: J A
authors.initials: JA
authors.lastname: Serra
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000150:complications / Q000473:pathology; D001786:Blood Glucose / Q000032:analysis*; D001921:Brain / Q000473:pathology; D015140:Dementia, Vascular / Q000097:blood* / Q000150:complications / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000473:pathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin