[Risk of second cancer after germinal cell testicular cancer: study from the data of Doubs cancer registry].
Testicular cancer, both seminoma and nonseminoma tumours, account for 1 to 1.5 % of male cancers. Many studies have shown that the risk of a second cancer after radiotherapy is dependent on the size of the exposure fields and the strength of delivered doses of radiotherapy. According to the literature, the relative risk of second cancer among patients treated by irradiation for seminoma limited to the testis varies from 1.5 to 1.9. We conducted a retrospective epidemiological study to measure the risk of second cancer in a population treated for both seminoma and nonseminoma tumours. The study period included patients who were diagnosed from 1978 to 2002. Data were provided by the Doubs cancer registry. Among these 291 cases of testicular cancer, we found 11 cases of second cancer after 157 seminomas (stomach, lungs, testis, ORL, kidney and oesophagus), and 3 cases after 134 nonseminomas (thyroid, kidney and testis). We found a high risk for second pulmonary and testicular cancers (standardised incidence ratio almost statistically significant). While our results are not conclusive regarding the etiology of these second cancers, they do form a useful, comparative basis for further study. They constitute the first step of a study that will be carried out on the risk related to radiation after orchidectomy.
Servagi-Vernat
Stéphanie
S
Service d'oncologie-radiothérapie, CHU, Hôpital Jean-Minjoz, 25000 Besançon.
Langlois-Jacques
Carole
C
Bontemps
Patrick
P
Cléro
Enora
E
Bosset
Jean-François
JF
Danzon
Arlette
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000453:epidemiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D012042:Registries; D013736:Testicular Neoplasms / Q000453:epidemiology*