Lack of association of -55CT polymorphism of UCP3 gene with fat distribution in obese patients.
OBJECTIVE
Some studies have pointed to a role of UCP3 in the regulation of whole-body energy homeostasis and regulation of fat distribution. The aim of our study was to investigate the influence of -55CT polymorphism of UCP3 gene on fat distribution and classical cardiovascular risk factors in obese patients.


METHODS
A population of 225 obese patients was analyzed in a prospective way. A nutritional evaluation was performed. Dietary intake and exercise were recorded. The genotype of UCP3 gene -55CT was studied.


RESULTS
225 patients gave informed consent and were enrolled. 178 (53 males/125 females) (79.1%) had genotype 55CC (wild group) and 47 patients (14 males/33 females) (20.9%) 55CT (mutant group). In the mutant group, resting metabolic rate was higher than in the wild group. However, resting metabolic rate corrected by fat-free mass was similar. No differences were detected in fat mass or other anthropometric parameters. C-reactive protein was higher in the mutant group than in the wild group (5.1 +/- 5.7 vs. 6.9 +/- 6.8 mg/dl; p < 0.05).


CONCLUSIONS
In the mutant group of -55CC UCP3 gene patients, C-reactive protein was higher than in the wild-type patients. However, no differences in anthropometric parameters were detected in either group.
de Luis
D A
DA
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es
Aller
R
R
Izaola
O
O
González Sagrado
M
M
Conde
R
R
Pérez Castrillón
J L
JL
D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000886:Anthropometry; D001823:Body Composition / Q000235:genetics*; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism*; D002153:Calorimetry, Indirect; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics*; D009154:Mutation; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012307:Risk Factors; D000071247:Uncoupling Protein 3
D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604392:UCP3 protein, human; D000071247:Uncoupling Protein 3; D002097:C-Reactive Protein