title: [Nausea and vomiting in the postoperative phase. Expert- and evidence-based recommendations for prophylaxis and therapy].
abstract: There are no consensus guidelines for the management of postoperative nausea and vomiting (PONV) in German speaking countries. This meeting was intended to develop such guidelines on which individual health care facilities can derive their specific standard operating procedures (SOPs). Anesthesiologists reviewed published literature on key topics which were subsequently discussed during two meetings. It was emphasized that recommendations were based on the best available evidence. The clinical relevance of individual risk factors should be viewed with caution since even well proven risk factors, such as the history of PONV, do not allow the identification of patients at risk for PONV with a satisfactory sensitivity or specificity. A more useful approach is the use of simplified risk scores which consider the presence of several risk factors simultaneously. Most individual antiemetic interventions for the prevention of PONV have comparable efficacy with a relative risk reduction of about 30%. This appears to be true for total intravenous anesthesia (TIVA) as well as for dexamethasone and other antiemetics; assuming a sufficiently high, adequate and equipotent dosage which should be weight-adjusted in children. As the relative risk reduction is context independent and similar between the interventions, the absolute risk reduction of prophylactic interventions is mainly dependent on the patient's individual baseline risk. Prophylaxis is thus rarely warranted in patients at low risk, generally needed in patients with a moderate risk and should include a multimodal approach in patients at high risk for PONV. Therapeutic interventions of PONV should be administered promptly using an antiemetic which has not been used before. The group suggests algorithms where prophylactic interventions are mainly dependent on the patient's risk for PONV. These algorithms should provide evidence-based guidelines allowing the development of SOPs/policies which take local circumstances into account.
authors.affiliation: Perioperative Clinical Research Core, Department of Anesthesia and Perioperative Care, University of California, San Francisco,UCSF Medical Center at Mt. Zion, 1600 Divisadero, C-355, San Francisco, California 94115-1605, USA. apfel@ponv.org
authors.forename: C C
authors.initials: CC
authors.lastname: Apfel
authors.forename: P
authors.initials: P
authors.lastname: Kranke
authors.forename: S
authors.initials: S
authors.lastname: Piper
authors.forename: D
authors.initials: D
authors.lastname: Rüsch
authors.forename: H
authors.initials: H
authors.lastname: Kerger
authors.forename: M
authors.initials: M
authors.lastname: Steinfath
authors.forename: K
authors.initials: K
authors.lastname: Stöcklein
authors.forename: D R
authors.initials: DR
authors.lastname: Spahn
authors.forename: T
authors.initials: T
authors.lastname: Möllhoff
authors.forename: K
authors.initials: K
authors.lastname: Danner
authors.forename: A
authors.initials: A
authors.lastname: Biedler
authors.forename: M
authors.initials: M
authors.lastname: Hohenhaus
authors.forename: B
authors.initials: B
authors.lastname: Zwissler
authors.forename: O
authors.initials: O
authors.lastname: Danzeisen
authors.forename: H
authors.initials: H
authors.lastname: Gerber
authors.forename: F-J
authors.initials: FJ
authors.lastname: Kretz
mesh_terms: D026881:Acupuncture; D000328:Adult; D000465:Algorithms; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous; D000932:Antiemetics / Q000627:therapeutic use; D002648:Child; D019317:Evidence-Based Medicine; D017408:Guidelines as Topic; D006801:Humans; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology / Q000517:prevention & control / Q000628:therapy*; D015742:Propofol; D012307:Risk Factors
chemical_list: D018686:Anesthetics, Intravenous; D000932:Antiemetics; D015742:Propofol