Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort.
Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.
Urowitz
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MB
SLICC Registry for Atherosclerosis Coordinating Centre, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada.
Gladman
D
D
Ibañez
D
D
Fortin
P
P
Sanchez-Guerrero
J
J
Bae
S
S
Clarke
A
A
Bernatsky
S
S
Gordon
C
C
Hanly
J
J
Wallace
D
D
Isenberg
D
D
Ginzler
E
E
Merrill
J
J
Alarcon
G
G
Steinsson
K
K
Petri
M
M
Dooley
M A
MA
Bruce
I
I
Manzi
S
S
Khamashta
M
M
Ramsey-Goldman
R
R
Zoma
A
A
Sturfelt
G
G
Nived
O
O
Maddison
P
P
Font
J
J
van Vollenhoven
R
R
Aranow
C
C
Kalunian
K
K
Stoll
T
T
Buyon
J
J
D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D017698:Postmenopause; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013997:Time Factors