title: [Myositis with pulmonary fibrosis and eosinophilia].
abstract: A 74-year old female patient suffered from dyspnoea, subfebrile body temperature, myalgias, arthralgias and presented a transitory skin rash. Further findings were an eosinophilia, synovitis, a myositis and pulmonary fibrosis. There was no evidence for a malignancy or an infectious disease. We diagnosed an Anti-Jo-1-Syndrome with a secondary Sjoegren syndrome. Immunsuppressive therapy with steroids, later in addition methotrexate led to improvement of the patient's clinical condition. Above mentioned symptoms and its differential diagnosis are discussed in this article.
authors.affiliation: Departement Innere Medizin, Kantonsspital Aarau.
authors.forename: G
authors.initials: G
authors.lastname: Tamborrini
authors.forename: N
authors.initials: N
authors.lastname: Exer
authors.forename: D
authors.initials: D
authors.lastname: Conen
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000368:Aged; D000974:Antibodies, Antinuclear; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D009220:Myositis / Q000175:diagnosis* / Q000188:drug therapy; D011658:Pulmonary Fibrosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic; D012859:Sjogren's Syndrome / Q000175:diagnosis*; D013577:Syndrome; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000974:Antibodies, Antinuclear; D007166:Immunosuppressive Agents; C046750:Jo-1 antibody; D008727:Methotrexate