Novel therapies to increase apolipoprotein AI and HDL for the treatment of atherosclerosis.
Apolipoprotein AI (apoAI) is the major protein component of HDL, and thus has an important role in the treatment of atherosclerosis. This review summarizes the various approaches being examined for raising levels of apoAI/HDL, including increasing the synthesis of apoAI and altering the metabolism of HDL. In addition, the currently available drugs used to increase apoAI/HDL are discussed, with a focus on the potential sites of action of these drugs on HDL metabolism. The outcome of further investigational studies into this field should provide effective therapies to increase apoAI/HDL levels and thus be of use in the treatment of cardiovascular disease.
Wong
Norman Cw
NC
University of Calgary, Health Sciences Center, Faculty of Medicine, Department of Medicine and Biochemistry, Gene Therapy Unit and Diabetes and Endocrine Research Group, 3330 Hospital Drive NW, Calgary, AB T2N4N1, Canada. ncwwong@ucalgary.ca
D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000818:Animals; D016632:Apolipoprotein A-I / Q000378:metabolism*; D050197:Atherosclerosis / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D020536:Enzyme Activators / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D050356:Lipid Metabolism / Q000187:drug effects*; D008075:Lipoproteins, HDL / Q000378:metabolism*; D010446:Peptide Fragments / Q000627:therapeutic use; D015854:Up-Regulation
D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D016632:Apolipoprotein A-I; D053480:Cholesterol Ester Transfer Proteins; D020536:Enzyme Activators; D004791:Enzyme Inhibitors; D000960:Hypolipidemic Agents; D008075:Lipoproteins, HDL; D010446:Peptide Fragments