title: Insights on the functional role of chromatin remodelers in osteogenic cells.
abstract: Control of eukaryotic gene expression requires interaction between sequence-specific transcription factors and their regulatory elements on the particular promoter. The dynamic alteration of chromatin structure regulates the accessibility of these elements in the genome and therefore contributes to the control of transcriptional activity. Here we discuss chromatin remodelling in the context of osteoblast lineage regulation. This review specifically highlights the role of the protein chromatin-related mesenchymal modulator (CReMM/CHD9), a recently identified chromatin remodeler, in osteogenic cell differentiation.
authors.affiliation: Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Israel. dafnab@post.tau.ac.il
authors.forename: Dafna
authors.initials: D
authors.lastname: Benayahu
authors.forename: Nitsan
authors.initials: N
authors.lastname: Shacham
authors.forename: Irena
authors.initials: I
authors.lastname: Shur
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D042002:Chromatin Assembly and Disassembly / Q000235:genetics / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D010012:Osteogenesis / Q000235:genetics* / Q000502:physiology*; D011401:Promoter Regions, Genetic; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators; D000255:Adenosine Triphosphate