Continuous venovenous hemodiafiltration for life-threatening mitochondrial myopathy with lactic acidosis and rhabdomyolysis.
We report here the clinical course of a 31-year-old male who recovered from a fulminant form of mitochondrial myopathy with lactic acidosis. The patient was transferred to our hospital with acute dyspnea and a convulsive seizure. On admission, he was in a state of shock, and presented with severe high-output heart failure, acute renal failure, and rhabdomyolysis. Treatment with continuous venovenous hemodiafiltration (CVVHDF) resulted in an excellent response, with no signs of hemodynamic instability. This case suggests that CVVHDF with serial hemodynamic monitoring may be effective in treating hypotensive patients with a life-threatening mitochondrial disorder.
Inoue
Shigeaki
S
Department of Critical Care and Emergency Medicine, Tokai University School of Medicine, Kanagawa, Japan. caf55000@pop12.odn.ne.jp
Nagayama
Masao
M
Aoki
Hiromichi
H
Tamura
Kozo
K
Suzuki
Yosuke
Y
Morita
Seiji
S
Nakagawa
Yoshihide
Y
Yamamoto
Isotoshi
I
Inokuchi
Sadaki
S
D000140:Acidosis, Lactic / Q000150:complications* / Q000628:therapy; D058186:Acute Kidney Injury / Q000150:complications / Q000628:therapy; D000328:Adult; D006440:Hemofiltration; D006801:Humans; D008297:Male; D017240:Mitochondrial Myopathies / Q000150:complications / Q000628:therapy*; D012206:Rhabdomyolysis / Q000150:complications* / Q000628:therapy