Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors.
Shao
Yi-Ming
YM
Genomics Research Center, Academia Sinica, No. 128, Sec. 2, Academia Rd., Taipei City 115, Taiwan, ROC.
Yang
Wen-Bin
WB
Peng
Hung-Pin
HP
Hsu
Min-Feng
MF
Tsai
Keng-Chang
KC
Kuo
Tun-Hsun
TH
Wang
Andrew H-J
AH
Liang
Po-Huang
PH
Lin
Chun-Hung
CH
Yang
An-Suei
AS
Wong
Chi-Huey
CH
D002626:Chemistry, Pharmaceutical / Q000379:methods; D000086782:Coronavirus 3C Proteases; D003460:Crystallization; D018360:Crystallography, X-Ray / Q000379:methods; D003546:Cysteine Endopeptidases; D015195:Drug Design; D006860:Hydrogen Bonding; D008024:Ligands; D008956:Models, Chemical; D008968:Molecular Conformation; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011487:Protein Conformation; D045473:Severe acute respiratory syndrome-related coronavirus / Q000201:enzymology*; D014764:Viral Proteins / Q000037:antagonists & inhibitors*; D014965:X-Rays
D008024:Ligands; D011480:Protease Inhibitors; D014764:Viral Proteins; D003546:Cysteine Endopeptidases; D000086782:Coronavirus 3C Proteases