The function of Dmrt genes in vertebrate development: it is not just about sex.
The Dmrt genes encode a large family of transcription factors whose function in sexual development has been well studied in invertebrates and vertebrates. Their expression pattern is not restricted to the developing gonads, indicating that Dmrt genes might regulate other developmental processes. Here we review the expression pattern of several members of this family across species and summarize recent findings on the function of a subset of these genes in non-gonadal tissues.
Hong
Chang-Soo
CS
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA.
Park
Byung-Yong
BY
Saint-Jeannet
Jean-Pierre
JP
D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D006803:Human Development; D006801:Humans; D009928:Organ Specificity; D019849:Sex Determination Processes; D012733:Sex Differentiation; D012725:Sexual Behavior; D014157:Transcription Factors / Q000235:genetics*
D029742:Caenorhabditis elegans Proteins; C110547:DMRT1 protein; D004268:DNA-Binding Proteins; C070369:DSX protein, Drosophila; D029721:Drosophila Proteins; C110548:Mab-3 protein, C elegans; D014157:Transcription Factors