title: [Comparative analysis of proteins in seminal plasma of non-obstructive azoospermia patients and healthy fertile males].
abstract: OBJECTIVE
  To analyse protein alterations in the seminal plasma of non-obstructive azoospermia patients.
  
  
  METHODS
  Semen samples were collected from 11 healthy fertile and 6 azoospermia male volunteers respectively and tested by SELDI-TOF-MS with CM10 protein chip to get protein spectra maps, which were automatically treated with the special softwares of Ciphergen Inc.
  
  
  RESULTS
  The mean peak heights of 28 proteins expressed in the seminal plasma of the azoospermia patients were statistically different from those of the healthy fertile males (P < 0.05 ), of which 24 were of lower contents than in the normal controls, 4 with remarkably significant difference, M/Z 7 196.058, 7 630.573, 7 547.610 and 7 709.833 (P < 0.01).
  
  
  CONCLUSIONS
  The seminal plasma proteins of the azoospermia patients were significantly different from those of the healthy fertile males, with decreased contents of most of the different proteins, which might be significantly correlated with the development of azoospermia.
authors.affiliation: Department of Clinical Laboratory, PLA General Hospital, Beijing 100853, China. jiebai69@tom.com
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.forename: Ling
authors.initials: L
authors.lastname: Sun
authors.forename: Shi-Ling
authors.initials: SL
authors.lastname: Chen
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Zhang
authors.forename: Jun-Long
authors.initials: JL
authors.lastname: Ma
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Cong
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000378:metabolism*; D006801:Humans; D008297:Male; D011506:Proteins / Q000032:analysis*; D040901:Proteomics / Q000379:methods*; D012661:Semen / Q000737:chemistry* / Q000166:cytology; D021241:Spectrometry, Mass, Electrospray Ionization; D013076:Sperm Count; D013081:Sperm Motility
chemical_list: D011506:Proteins