Effects of gastric electrical stimulation with short pulses and long pulses on gastric dysrhythmia and signs induced by vasopressin in dogs.
OBJECTIVE
This study was to investigate the effect of gastric electrical stimulation (GES) with short pulses, long pulses, short-pulse trains or long-pulse trains on gastric dysrhythmia and motion-sickness signs induced by vasopressin.


METHODS
Seven male beagle dogs implanted with four pairs of electrodes on gastric serosa were studied. The study was performed in six sessions in a randomized order. In session 1 or 2, either saline or vasopressin was infused without GES. In session 3, 4, 5 and 6, GES with short pulses, long pulses, trains of short pulses or trains of long pulses was performed before and during vasopressin infusion. Gastric slow waves and motion-sickness signs were recorded in each session.


RESULTS
(1) Vasopressin induced gastric dysrhythmia and motion sickness-like signs (ANOVA, P < 0.001). (2) GES with short pulses or trains of short pulses was capable of preventing vasopressin-induced emetic response (P < 0.001), but did not normalize gastric dysrhythmia. (3) GES with long pulses or trains of long pulses was able to normalize gastric dysrhythmia induced by vasopressin (P < 0.001), but showed no effects on vasopressin-induced motion-sickness signs.


CONCLUSIONS
GES with short pulses or trains of short pulses prevents vasopressin-induced emetic response with no improvement in gastric dysrhythmia. GES with long pulses or trains of long pulses normalizes gastric dysrhythmia induced by vasopressin with no effects on signs.
Hou
Xiaohua
X
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China. houxh@public.wh.hb.cn
Song
Geng-Qing
GQ
Yang
Bin
B
Sun
Yan
Y
Qian
Wei
W
Chen
Jiande D Z
JD
D000818:Animals; D004285:Dogs; D004599:Electric Stimulation Therapy / Q000379:methods*; D005769:Gastrointestinal Motility / Q000502:physiology*; D008297:Male; D009041:Motion Sickness / Q000139:chemically induced / Q000628:therapy*; D013272:Stomach Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D014667:Vasopressins
D014667:Vasopressins