title: Effects of gastric electrical stimulation with short pulses and long pulses on gastric dysrhythmia and signs induced by vasopressin in dogs.
abstract: OBJECTIVE
  This study was to investigate the effect of gastric electrical stimulation (GES) with short pulses, long pulses, short-pulse trains or long-pulse trains on gastric dysrhythmia and motion-sickness signs induced by vasopressin.
  
  
  METHODS
  Seven male beagle dogs implanted with four pairs of electrodes on gastric serosa were studied. The study was performed in six sessions in a randomized order. In session 1 or 2, either saline or vasopressin was infused without GES. In session 3, 4, 5 and 6, GES with short pulses, long pulses, trains of short pulses or trains of long pulses was performed before and during vasopressin infusion. Gastric slow waves and motion-sickness signs were recorded in each session.
  
  
  RESULTS
  (1) Vasopressin induced gastric dysrhythmia and motion sickness-like signs (ANOVA, P < 0.001). (2) GES with short pulses or trains of short pulses was capable of preventing vasopressin-induced emetic response (P < 0.001), but did not normalize gastric dysrhythmia. (3) GES with long pulses or trains of long pulses was able to normalize gastric dysrhythmia induced by vasopressin (P < 0.001), but showed no effects on vasopressin-induced motion-sickness signs.
  
  
  CONCLUSIONS
  GES with short pulses or trains of short pulses prevents vasopressin-induced emetic response with no improvement in gastric dysrhythmia. GES with long pulses or trains of long pulses normalizes gastric dysrhythmia induced by vasopressin with no effects on signs.
authors.affiliation: Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China. houxh@public.wh.hb.cn
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Hou
authors.forename: Geng-Qing
authors.initials: GQ
authors.lastname: Song
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Qian
authors.forename: Jiande D Z
authors.initials: JD
authors.lastname: Chen
mesh_terms: D000818:Animals; D004285:Dogs; D004599:Electric Stimulation Therapy / Q000379:methods*; D005769:Gastrointestinal Motility / Q000502:physiology*; D008297:Male; D009041:Motion Sickness / Q000139:chemically induced / Q000628:therapy*; D013272:Stomach Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D014667:Vasopressins
chemical_list: D014667:Vasopressins