title: An update in neoadjuvant chemotherapy in cervical cancer.
abstract: More than two decades have passed since neoadjuvant chemotherapy has been introduced in the clinical practice. After several pilot studies, randomized trials and meta-analysis have confirmed the validity of this therapeutic strategy and in particular of neoadjuvant chemotherapy followed by radical surgery. Several open questions still remain unanswered and in particular no standard drug regiment is unanimously accepted. In this paper we describe how this treatment has evolved since its original introduction in the early eighties and describe possible drug regimens with their supporting evidence that can be adopted by physicians worldwide.
authors.affiliation: Institute of Gynecology, Perinatology and Child Health, La Sapienza University, Viale del Policlinico, 155, 00100 Rome, Italy. pierluigi.benedettipanici@uniroma1.it
authors.forename: Pieluigi
authors.initials: P
authors.lastname: Benedetti Panici
authors.forename: Filippo
authors.initials: F
authors.lastname: Bellati
authors.forename: Maria
authors.initials: M
authors.lastname: Pastore
authors.forename: Natalina
authors.initials: N
authors.lastname: Manci
authors.forename: Angela
authors.initials: A
authors.lastname: Musella
authors.forename: Simona
authors.initials: S
authors.lastname: Pauselli
authors.forename: Michela
authors.initials: M
authors.lastname: Angelucci
authors.forename: Ludovico
authors.initials: L
authors.lastname: Muzii
authors.forename: Roberto
authors.initials: R
authors.lastname: Angioli
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery