[Characteristics of hypothyroidism correction and lipid metabolism disorder in iodine deficiency].
The serum biochemical indexes (level of triiodthyronine, thyroxin, thyrothropic hormone of adenohypophysis, level of cholesterol, triglycerides) and the level of iodine excretion with urine in rats with hypothyrosis corrected by "Iodid-100" and along with excessive intake of chlorine and fluorine ions into the organism had been studied. It has been revealed that hypothyrosis has negative influence on lipid metabolism indexes. "Iodid- 100" usage stabilized hormonal and lipid status. Excessive intake of chlorine and fluorine ions by the organism decreased the effectiveness of iodine containing drugs.
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D000818:Animals; D004195:Disease Models, Animal; D004347:Drug Interactions; D007037:Hypothyroidism / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D007454:Iodides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D008713:Methimazole / Q000494:pharmacology; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology; D013963:Thyroid Hormones / Q000097:blood
D007454:Iodides; D013963:Thyroid Hormones; D012965:Sodium Chloride; D008713:Methimazole; D012969:Sodium Fluoride; D007455:Iodine