title: [Persistent forms of cow's milk allergy. Report of 6 cases].
abstract: BACKGROUND
  Cow's milk allergy is defined as reproducible adverse reaction to a food protein antigen which is immune medieted. About 80 to 90 % become clinically tolerated within the first three year of live. The aim of this study is to evaluate the clinical, immunological and evolutive characteristics of the 10 % to 20 % of persistent form of cow's milk allergy.
  
  
  METHODS
  This study included six persistent form of cow's milk allergy (2 boys and 4 girls). The provocation challenge test according to Rance recommendation, have been made from 6 months to one year.
  
  
  RESULTS
  4/6 infants with persistent cow's milk allergy have an atopic familial disease. Clinical presentation changed over time at once symptoms were preventely gastrointestinal, at the end there was an increased frequency of atopic disease (asthma: 4/6 infants)
  
  
  CONCLUSIONS
  Persistent form of cow's milk allergy are characterized by considerable importance of familial atopic disease; change in cow's milk allergy manifestations over time and more prolonged delay between cow's milk persistent consumption and manifestations of symptoms.
authors.affiliation: Service de Pédiatrie, CHU Hédi Choker, Sfax, Tunisie.
authors.forename: Nabil
authors.initials: N
authors.lastname: Ben Halima
authors.forename: Anas
authors.initials: A
authors.lastname: Krichen
authors.forename: Mohamed Ali
authors.initials: MA
authors.lastname: Mekki
authors.forename: Mansour Lamia
authors.initials: ML
authors.lastname: Ben
authors.forename: Imene
authors.initials: I
authors.lastname: Chabchoub
authors.forename: Melek
authors.initials: M
authors.lastname: Chaabouni
authors.forename: Ali
authors.initials: A
authors.lastname: Triki
authors.forename: Abderrahmen
authors.initials: A
authors.lastname: Karray
mesh_terms: D000818:Animals; D001249:Asthma / Q000150:complications; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008892:Milk / Q000009:adverse effects*; D016269:Milk Hypersensitivity / Q000150:complications* / Q000276:immunology; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E