title: MeTaDoR: a comprehensive resource for membrane targeting domains and their host proteins.
abstract: BACKGROUND
  Protein-lipid interactions play a central role in cellular signaling and membrane trafficking and at the core of these interactions are domains specialized in lipid binding and membrane targeting. Considering the importance of these domains, we have created MeTaDoR, a comprehensive resource dedicated to membrane targeting domains (MTDs).
  
  
  RESULTS
  MeTaDoR begins with a brief introduction about all the important MTDs including their subcellular localization and structural features. Sequences of all known MTDs are then provided in two formats: standard Prosite format and a parsed tab-delimited format that provides a manually curated classification into binding or non-binding. Structures of all MTDs and host proteins known so far are provided with links to PDB and Pfam databases. Membrane-binding orientation of these proteins, whether experimentally determined or proposed, is also provided with links to the appropriate literature. To facilitate molecular dynamics studies of these proteins, the force-field parameters for many non-standard lipids that commonly interact with these proteins are also provided. Finally, an online server for predicting membrane-binding proteins and a search function with various search fields are included. The resource is publicly available and will be updated on a regular basis.
authors.affiliation: Bioinformatics Program, Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
authors.forename: Nitin
authors.initials: N
authors.lastname: Bhardwaj
authors.forename: Robert V
authors.initials: RV
authors.lastname: Stahelin
authors.forename: Guijun
authors.initials: G
authors.lastname: Zhao
authors.forename: Wonhwa
authors.initials: W
authors.lastname: Cho
authors.forename: Hui
authors.initials: H
authors.lastname: Lu
mesh_terms: D001665:Binding Sites; D030562:Databases, Protein; D016247:Information Storage and Retrieval / Q000379:methods; D021962:Membrane Microdomains / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry*; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D017434:Protein Structure, Tertiary; D014584:User-Computer Interface
chemical_list: D008565:Membrane Proteins