Combined tipranavir and enfuvirtide use associated with higher plasma tipranavir concentrations but not with increased hepatotoxicity: sub-analysis from RESIST.
In RESIST, enfuvirtide co-administered with ritonavir-boosted tipranavir was associated with higher plasma tipranavir concentrations, which seldom rose above those associated with an increased risk of grade 3/4 transaminase elevations. Transaminase elevation rates (6.5%) and clinical hepatic event rates (5.9 events/100 person exposure years) were lower in the tipranavir/ritonavir with enfuvirtide group than in the tipranavir/ritonavir without enfuvirtide group. Observed increases in plasma tipranavir concentrations thus had no apparent effect on the risk of hepatotoxicity.
Raffi
François
F
University of Nantes, Nantes, France.
Battegay
Manuel
M
Rusconi
Stefano
S
Opravil
Milos
M
Blick
Gary
G
Steigbigel
Roy T
RT
Kraft
Michael
M
Neubacher
Dietmar
D
Sabo
John P
JP
D000410:Alanine Transaminase / Q000097:blood; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury; D004359:Drug Therapy, Combination; D000077560:Enfuvirtide; D015700:HIV Envelope Protein gp41 / Q000627:therapeutic use*; D023581:HIV Fusion Inhibitors / Q000627:therapeutic use; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D015497:HIV-1; D006801:Humans; D008107:Liver Diseases / Q000201:enzymology; D061466:Lopinavir; D010446:Peptide Fragments / Q000627:therapeutic use*; D011725:Pyridines / Q000097:blood / Q000627:therapeutic use*; D011744:Pyrimidinones / Q000627:therapeutic use; D011753:Pyrones / Q000097:blood / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D019438:Ritonavir / Q000627:therapeutic use; D019258:Saquinavir / Q000627:therapeutic use; D013449:Sulfonamides; D016896:Treatment Outcome; D019562:Viral Load
D019380:Anti-HIV Agents; D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors; D017320:HIV Protease Inhibitors; D010446:Peptide Fragments; D011725:Pyridines; D011744:Pyrimidinones; D011753:Pyrones; D013449:Sulfonamides; D000077560:Enfuvirtide; D061466:Lopinavir; D000410:Alanine Transaminase; D019258:Saquinavir; D019438:Ritonavir; C107201:tipranavir