title: Vessel wall stiffness in type 1 diabetes and the central hemodynamic effects of acute hypoglycemia.
abstract: OBJECTIVE
  To examine the effects of intravenous insulin and acute hypoglycemia on arterial wall stiffness and central hemodynamic responses in adults with and without type 1 diabetes.
  
  
  METHODS
  In 30 young male volunteers [10 nondiabetic (Group 1); 10 with type 1 diabetes, <5 yr duration (Group 2); 10 with type 1 diabetes, >15 yr duration (Group 3)], intravenous insulin was administered to provoke an acute autonomic reaction (R) to hypoglycemia. Heart rate, peripheral blood pressure, and pulse wave analysis (radial artery) were monitored. Augmentation index (AIx), a measure of arterial wall stiffness and wave reflection, and central arterial pressure were recorded.
  
  
  RESULTS
  At baseline, no significant differences were observed between Groups 1 and 2 in either AIx or in central arterial pressure, but in Group 3, both measures were significantly higher. All three groups exhibited similar responses to intravenous infusion of insulin and to hypoglycemia: AIx fell progressively from baseline to R, peripheral systolic blood pressure increased, and central systolic pressure decreased.
  
  
  CONCLUSIONS
  Compared with age- and sex-matched nondiabetic controls, people who had type 1 diabetes for a long duration had increased stiffness of vessel walls. The opposing responses in peripheral and central systolic pressures during hypoglycemia may be related to the reduction in AIx, which causes diminished amplification of the systolic pressure wave. Changes in AIx are probably mediated by a direct action of insulin on arterial endothelium, or changes in heart rate. These functional changes may contribute to the increased cardiovascular morbidity that is associated with type 1 diabetes of long duration.
authors.affiliation: Department of Diabetes, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, Scotland, UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Sommerfield
authors.forename: Ian B
authors.initials: IB
authors.lastname: Wilkinson
authors.forename: David J
authors.initials: DJ
authors.lastname: Webb
authors.forename: Brian M
authors.initials: BM
authors.lastname: Frier
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000503:physiopathology*; D007328:Insulin / Q000502:physiology*; D008297:Male; D017534:Radial Artery / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D007328:Insulin