Revving the engine: signal transduction fuels T cell activation.
For initiation of an immune response, resting T cells must reprogram their metabolism. Continuing the "From the Field" series (see Editorial [2007] 26, 131), Jones and Thompson draw attention to the importance of metabolism during T cell activation and consider how this process is regulated by receptor-mediated signal transduction.
Jones
Russell G
RG
Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Thompson
Craig B
CB
D000818:Animals; D006019:Glycolysis; D006801:Humans; D008213:Lymphocyte Activation; D008928:Mitochondria / Q000378:metabolism; D014176:Protein Biosynthesis; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism