title: Histologic analysis of the acellular dermal matrix graft incorporation process: a pilot study in dogs.
abstract: Clinical results with acellular dermal matrix graft (ADMG) in periodontal surgeries suggest that the material is incorporated by the host tissues. However, histologic studies of the ADMG incorporation process are limited. The objective of this study was to evaluate the incorporation of ADMG into gingival tissues in a dog model. Gingival recession-type defects were created at the canines of six dogs. After 6 weeks, periodontal surgeries to repair the defects were performed using ADMG. Two animals each were sacrificed after 4, 8, and 12 weeks. At 4 weeks, thick collagen fibers from the ADMG were clearly seen in the connective tissue, and some blood vessels were penetrating into the ADMG. At 8 weeks, blood vessel penetration was enhanced, and collagen fiber bundles from the ADMG were seen sending branches into the connective tissue in all directions. After 12 weeks, the ADMG and the connective tissue seemed to be well integrated into a single highly vascularized structure, indicating almost complete incorporation of the ADMG.
authors.affiliation: Department of Bucco-Maxillo-Facial Surgery and Traumatology and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: Sonia M
authors.initials: SM
authors.lastname: Luczyszyn
authors.forename: Márcio F M
authors.initials: MF
authors.lastname: Grisi
authors.forename: Arthur B
authors.initials: AB
authors.lastname: Novaes
authors.forename: Daniela B
authors.initials: DB
authors.lastname: Palioto
authors.forename: Sérgio L S
authors.initials: SL
authors.lastname: Souza
authors.forename: Mario
authors.initials: M
authors.lastname: Taba
mesh_terms: D000818:Animals; D003094:Collagen; D004285:Dogs; D005889:Gingival Recession / Q000601:surgery*; D010865:Pilot Projects; D012867:Skin / Q000378:metabolism; D016038:Skin Transplantation / Q000502:physiology*; D017768:Skin, Artificial
chemical_list: C440568:Alloderm; D003094:Collagen