title: Use of Glubran 2 acrylic glue in interventional neuroradiology.
abstract: BACKGROUND
  Glubran 2 is a cyanoacrylate-based synthetic glue modified by the addition of a monomer synthesized by the manufacturer. With this material it is possible to obtain the stability of endovascular embolization that is needed to treat tumours and vascular disease.
  
  
  METHODS
  We report our 3-year experience of the use of Glubran for treating extracerebral tumours, spinal tumours, spinal arteriovenous malformations, and brain and spine dural fistulae. Glubran 2 was diluted with Lipiodol and injected in a continuous column with the flow rate monitored by seriography. The injection was stopped when retrograde flow was displayed in the afferent vessel.
  
  
  RESULTS
  There were no periprocedural or subsequent clinical complications and the glue resulted in successful selective permanent occlusion with intralesional penetration similar to the angiographic features of microcatheterization.
  
  
  CONCLUSIONS
  The embolization procedure was technically straightforward and relatively safe. However, Glubran 2 can be difficult to use and the procedure does carry major risks for patients. Glue injection requires in-depth study of the lesion, its circulation and the collateral circulation to avoid severe complications due to inappropriate use.
authors.affiliation: Servizio di Neuroradiologia, Ospedale Bellaria, Via Altura 3, 40139 Bologna, Italy. luisa.raffi@ausl.bologna.it
authors.forename: L
authors.initials: L
authors.lastname: Raffi
authors.forename: L
authors.initials: L
authors.lastname: Simonetti
authors.forename: P
authors.initials: P
authors.lastname: Cenni
authors.forename: M
authors.initials: M
authors.lastname: Leonardi
mesh_terms: D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000175:diagnosis / Q000628:therapy*; D002533:Cerebral Angiography; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013122:Spinal Diseases / Q000175:diagnosis / Q000628:therapy*; D014014:Tissue Adhesives / Q000008:administration & dosage*
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C421461:glubran 2