title: [Pulmonary aspergillosis in a child with chronic granulomatous disease].
abstract: The chronic granulomatous disease is characterised by the occurence of multiple bacterial and fungal infections since the early childhood. This susceptibility to infections must be prevented by a primary prophlylaxis against the opportunistic germs like pneumocystis and aspergillus. Our case is about a twelve-year-old boy who had a prophylaxis since his fourth month of life. At 10 years he presented a pleuro-pneumonia refractory to a large spectrum antibiotherapy. The aspergillar etiology was established on clinical, radiological and serological arguments. An amphotericine B treatment allowed a good clinical and radiological outcome of this pleuro-pulmonary affection. However, a dorsal spondylodiscitis complicated the course of the disease. A secondary vertebral aspergillosis or a Pott's disease were suspected. The vertebral bipsy was'nt conclusive. The association of antituberculous and antifungal agents with adjuvant molecules (IFN, granulotic transfusions and GM-CSF) permitted a good clinical outcome and the stabilisation of the radiological lesions.
authors.affiliation: Service de Pédiatrie, EPS la Rabta.
authors.forename: Mohamed Slim
authors.initials: MS
authors.lastname: Abdelmoula
authors.forename: Rim
authors.initials: R
authors.lastname: Abdelmalek
authors.forename: Kais
authors.initials: K
authors.lastname: Chleyfa
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bejaoui
authors.forename: Néji
authors.initials: N
authors.lastname: Tebib
authors.forename: Hadhami
authors.initials: H
authors.lastname: Ben Turkia
authors.forename: Marie Françoise
authors.initials: MF
authors.lastname: Ben Dridi
mesh_terms: D001228:Aspergillosis / Q000150:complications*; D002648:Child; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications*; D008297:Male