title: Resistance to viral infection of super p53 mice.
abstract: Induction of expression of the tumor suppressor p53 after interferon treatment has been recently demonstrated (Takaoka et al., 2003), suggesting an antiviral activity of the protein. In addition, a direct correlation between p53 levels and tumor resistance has been addressed by generating mice with an extra copy of p53 ('super p53' mice) (Garcia-Cao et al., 2002). Here, we show that vesicular stomatitis virus replication in mouse embryo fibroblasts derived from 'super p53' mice is impaired as a result of apoptosis induction via p53 activation. These findings unequivocally demonstrate an antiviral activity of p53, a process that may contribute to inhibit the spread of the virus in vivo.
authors.affiliation: Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramon y Cajal sn, Madrid 28040, Spain.
authors.forename: Cesar
authors.initials: C
authors.lastname: Munoz-Fontela
authors.forename: Maria Angel
authors.initials: MA
authors.lastname: Garcia
authors.forename: Isabel
authors.initials: I
authors.lastname: Garcia-Cao
authors.forename: Manuel
authors.initials: M
authors.lastname: Collado
authors.forename: Javier
authors.initials: J
authors.lastname: Arroyo
authors.forename: Mariano
authors.initials: M
authors.lastname: Esteban
authors.forename: Manuel
authors.initials: M
authors.lastname: Serrano
authors.forename: Carmen
authors.initials: C
authors.lastname: Rivas
mesh_terms: D000818:Animals; D017209:Apoptosis; D005347:Fibroblasts; D018628:Gene Dosage; D007113:Immunity, Innate; D007372:Interferons / Q000494:pharmacology; D051379:Mice; D018353:Rhabdoviridae Infections / Q000276:immunology / Q000517:prevention & control*; D013280:Stomatitis / Q000276:immunology / Q000517:prevention & control; D019076:Transgenes; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000502:physiology*; D014616:Vaccinia virus / Q000502:physiology; D014721:Vesicular stomatitis Indiana virus / Q000502:physiology*; D014779:Virus Replication
chemical_list: D016159:Tumor Suppressor Protein p53; D007372:Interferons