Plasma concentrations of voriconazole in falcons.
Doses of 12.5 mg voriconazole/kg bodyweight administered every 12 hours by crop gavage to six falcons for 14 days provided peak plasma concentrations of more than 1 microg/ml, but the trough concentrations were lower and sometimes undetectable. Administering the same doses incorporated into meat that was fed to one falcon for seven days and to three falcons for up to 91 days provided similar plasma concentrations.
Schmidt
V
V
Clinic for Birds and Reptiles, University of Leipzig, An den Tierkliniken 15, D-04103 Leipzig, Germany.
Demiraj
F
F
Di Somma
A
A
Bailey
T
T
Ungemach
F R
FR
Krautwald-Junghanns
M-E
ME
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D001228:Aspergillosis / Q000188:drug therapy / Q000662:veterinary*; D001682:Biological Availability; D001715:Bird Diseases / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D046093:Falconiformes / Q000097:blood*; D005260:Female; D008297:Male; D011743:Pyrimidines / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole