Synthesis of new chiral cis-3-hydroxyazetidines and their application in diethylzinc addition to aldehydes.
A new series of chiral cis-3-hydroxyazetidines have been prepared from (R)-1-phenylethylamine. They have excellent catalytic activities and enantiomeric selectivities in asymmetric addition of diethylzinc to aromatic aldehydes.
Zhang
Zhanbin
Z
Department of Chemistry, Beijing Normal University, Beijing, China.
Li
Min
M
Zi
Guofu
G