[Animal models in sexual dysfunction].
Animal models in sexual dysfunction were reviewed to further improve the modeling methods and to promote the effectiveness of drug evaluation translation from animal models to humans. A MEDLINE search was performed to retrieve articles relating to animal models in sexual dysfunction. Researches on a variety of animal models in sexual dysfunction, with their own merits, has to a certain extent contributed to the understanding of sexual function. However, no models could give a fully accurate assessment of sexual function. The existing sexual function studies on animal models of interpretive function, the development mechanisms, the effects of drugs on sexual function and the clinical translation still have some deficiencies, but with their basic principles and ideas for the improvement of the models and the preservation of the valuable data of drugs and clinical trials.
Deng
Shi-Zhou
SZ
Department of Urology, People's Hospitial, Peking University, Beijing 100044, China.
Bai
Wen-Jun
WJ
Wang
Xiao-Feng
XF
D000818:Animals; D004195:Disease Models, Animal; D015195:Drug Design; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy / Q000503:physiopathology*