Novel anti-tuberculosis agents from MCR libraries.
Structure-based design of libraries of multi-component reaction products yields novel potent anti-tuberculosis compounds. Synthesis and preliminary biological results are presented.
Dömling
Alexander
A
Department of Pharmaceutical Sciences, University of Pittsburgh, BST3 10019, Pittsburgh, PA 15621, USA. asd30+@pitt.edu
Achatz
Sepp
S
Beck
Barbara
B
D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D015723:Gene Library; D006801:Humans; D066298:In Vitro Techniques; D007538:Isoniazid / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics*; D020543:Proteome; D014709:Vero Cells
D000995:Antitubercular Agents; D020543:Proteome; D007538:Isoniazid