title: A unique physical-chemistry approach for fabricating cell friendly surfaces.
abstract: Recent interests in the fabrication of bio/cell-friendly surfaces are consistently gaining much scientific coverage as these methods could be explored as novel regenerative and therapeutic medicinal protocols. Essentially two main components govern this aspect, the processing methodology possessing the required robustness to fabricate a wide range of materials and, not least, the synthesised materials that need to be cell-compatible both in the short and long term after processing. In the study reported here we have combined one such robust jetting approach with a specially formulated siloxane sol. This has several unique properties in itself, and these have been demonstrated here to have a positive effect on the seeded cells. The current work demonstrates that this approach has great promise as a novel methodology for surface engineering for a wide range of applications spanning the physical to the life science areas of research.
authors.affiliation: Molecular Immunology Unit, Institute of Child Health, University College London, London, UK.
authors.forename: Scott
authors.initials: S
authors.lastname: Irvine
authors.forename: Alice C
authors.initials: AC
authors.lastname: Sullivan
authors.forename: Jean R
authors.initials: JR
authors.lastname: McEwan
authors.forename: Suwan N
authors.initials: SN
authors.lastname: Jayasinghe
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods*; D002627:Chemistry, Physical / Q000379:methods*; D008422:Materials Testing; D013499:Surface Properties; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods*
chemical_list: D001672:Biocompatible Materials