title: Virological fitness of HIV in patients with resistance to enfuvirtide.
abstract: Resistance to the HIV fusion inhibitor enfuvirtide is associated with mutations in the first heptad repeat region of gp41, but little is known of their impact on replicative fitness in vivo. We followed seven patients undergoing salvage therapy that included enfuvirtide in order to document the temporal generation of genotypic and phenotypic resistance in parallel with replicative fitness. Resistance to enfuvirtide was not associated with decreased replicative fitness of HIV strains infecting these patients.
authors.affiliation: Victorian Infectious Diseases Reference Laboratory, Melbourne, Australia.
authors.forename: Doris
authors.initials: D
authors.lastname: Chibo
authors.forename: Norman
authors.initials: N
authors.lastname: Roth
authors.forename: Vanessa
authors.initials: V
authors.lastname: Roulet
authors.forename: Katharina
authors.initials: K
authors.lastname: Skrabal
authors.forename: Megan
authors.initials: M
authors.lastname: Gooey
authors.forename: Louise
authors.initials: L
authors.lastname: Carolan
authors.forename: Jodie
authors.initials: J
authors.lastname: Nicholls
authors.forename: Anastasia
authors.initials: A
authors.lastname: Papadakis
authors.forename: Chris
authors.initials: C
authors.lastname: Birch
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D018791:CD4 Lymphocyte Count; D024882:Drug Resistance, Viral / Q000235:genetics; D000077560:Enfuvirtide; D005838:Genotype; D006678:HIV / Q000187:drug effects / Q000235:genetics*; D015700:HIV Envelope Protein gp41 / Q000627:therapeutic use*; D023581:HIV Fusion Inhibitors / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics; D006801:Humans; D009154:Mutation; D010446:Peptide Fragments / Q000627:therapeutic use*; D010641:Phenotype; D017211:Treatment Failure; D019562:Viral Load; D014779:Virus Replication / Q000235:genetics
chemical_list: D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors; D010446:Peptide Fragments; D000077560:Enfuvirtide