title: Early disseminated borreliosis with multiple erythema migrans and elevated liver enzymes: case report and literature review.
abstract: A 69-year-old man presented with multiple livid maculae and infiltrated urticarial plaques, as well as elevated liver enzymes. Based on typical clinical picture, histopathology and positive PCR from a skin biopsy, we diagnosed an early disseminated infection with Borrelia afzelii presenting with multiple erythema migrans (erythemata migrantia) and a subclinical hepatitis. During antibiotic treatment with intravenous ceftriaxone, the maculae and plaques vanished almost completely and the liver enzymes decreased within 14 days. Dermatologists should keep in mind that early disseminated borreliosis can present with multiple erythema migrans and hepatitis.
authors.affiliation: Department of Dermatology, Eberhard Karls University Tübingen. frauke.benedix@med.uni-tuebingen.de
authors.forename: Frauke
authors.initials: F
authors.lastname: Benedix
authors.forename: Benjamin
authors.initials: B
authors.lastname: Weide
authors.forename: Sigrid
authors.initials: S
authors.lastname: Broekaert
authors.forename: Gisela
authors.initials: G
authors.lastname: Metzler
authors.forename: Julia-Stefanie
authors.initials: JS
authors.lastname: Frick
authors.forename: Walter H C
authors.initials: WH
authors.lastname: Burgdorf
authors.forename: Martin
authors.initials: M
authors.lastname: Röcken
authors.forename: Martin
authors.initials: M
authors.lastname: Schaller
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000032:analysis*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D015748:Borrelia burgdorferi Group / Q000302:isolation & purification; D002097:C-Reactive Protein / Q000032:analysis; D002443:Ceftriaxone / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D015787:Erythema Chronicum Migrans / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006506:Hepatitis A / Q000382:microbiology; D006529:Hepatomegaly / Q000382:microbiology; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D008193:Lyme Disease / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D012867:Skin / Q000473:pathology; D005723:gamma-Glutamyltransferase / Q000032:analysis*
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D004318:Doxycycline