title: Association of classical and related inflammatory markers with high-sensitivity C-reactive protein in healthy individuals: results from the Stanislas cohort.
abstract: BACKGROUND
  Although high-sensitivity C-reactive protein (hs-CRP) has emerged as a cardiovascular marker, questions arise regarding the relative information provided by other inflammatory molecules. Therefore, as a first step, we examined interrelationships between serum hs-CRP concentrations and inflammatory, adhesion and growth factors in healthy adults.
  
  
  METHODS
  Circulating concentrations of hs-CRP, haptoglobin, orosomucoid, interleukin-6 (IL-6), IL-8, IL-18, tumor necrosis factor-alpha (TNF-alpha), TNF-receptor II (TNF-RII), E-, P-, and L-selectins, intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1, endothelial growth factor (EGF), vascular EGF (VEGF), insulin-like growth factor-1 (IGF-1) and IGF-binding protein (IGFBP-3) were measured in 154 men and 161 women of the Stanislas cohort. Leukocyte and platelet counts were also determined.
  
  
  RESULTS
  Correlations were significant between hs-CRP concentrations and leukocyte and platelet counts, as well as haptoglobin, orosomucoid, IL-6, and ICAM-1 concentrations (p< or =0.001). Correlation coefficients for ICAM-1 were higher in men than in women (p< or =0.05). When stratifying subjects according to hs-CRP levels, the group with high hs-CRP levels had significantly higher haptoglobin and orosomucoid concentrations than the others, in addition to higher leukocyte counts and IL-6 concentrations in women, and platelet counts and ICAM-1 concentrations in men.
  
  
  CONCLUSIONS
  Further studies are warranted to explain the association pattern for hs-CRP. Partition of these factors according to their association with hs-CRP concentration opens a new perspective for choice of the best factors in terms of cardiovascular risk in relation to hs-CRP, while non-associated markers could be used to give additional information.
authors.affiliation: INSERM, U525, équipe 4, Nancy, France.
authors.forename: Hind
authors.initials: H
authors.lastname: Berrahmoune
authors.forename: Bernard
authors.initials: B
authors.lastname: Herbeth
authors.forename: John V
authors.initials: JV
authors.lastname: Lamont
authors.forename: Daniel
authors.initials: D
authors.lastname: Lambert
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
authors.forename: Laurence
authors.initials: L
authors.lastname: Tiret
authors.forename: Peter S
authors.initials: PS
authors.lastname: FitzGerald
authors.forename: Gérard
authors.initials: G
authors.lastname: Siest
authors.forename: Sophie
authors.initials: S
authors.lastname: Visvikis-Siest
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001772:Blood Cell Count; D002097:C-Reactive Protein / Q000032:analysis*; D002675:Child, Preschool; D015331:Cohort Studies; D004815:Epidermal Growth Factor / Q000032:analysis; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000473:pathology; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000032:analysis; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D007378:Interleukins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000032:analysis; D019087:Selectins / Q000032:analysis; D048069:Tumor Necrosis Factors / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
chemical_list: D015415:Biomarkers; D006242:Haptoglobins; D018972:Insulin-Like Growth Factor Binding Protein 3; D007378:Interleukins; D009961:Orosomucoid; D019087:Selectins; D048069:Tumor Necrosis Factors; D042461:Vascular Endothelial Growth Factor A; D018799:Intercellular Adhesion Molecule-1; D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein