[Clinical features of 17 patients with familial non medullary thyroid carcinoma].
BACKGROUND
Papillary thyroid carcinoma can have familial aggregation.


OBJECTIVE
To compare retrospectively familial non medullary thyroid carcinoma (FNMTC) with sporadic papillary thyroid carcinoma (PTC).


METHODS
Retrospective analysis of medical records of patients with thyroid carcinoma. An index case was defined as a subject with the diagnosis of differentiated thyroid carcinoma with one or more first degree relatives with the same type of cancer. Seventeen such patients were identified and were compared with 352 subjects with PTC.


RESULTS
The most common affected relatives were sisters. Patients with FNMTC were younger than those with PTC. No differences were observed in gender, single or multiple foci, thyroid capsule involvement, surgical border involvement, number of affected lymph nodes and coexistence of follicular hyperplasia. Patients with FNMTC had smaller tumors and had a nine times more common association with lymphocytic thyroiditis. Five patients with FNMTC had local recurrence during 4.8 years of follow up.


CONCLUSIONS
Patients with FNMTC commonly have an associated chronic thyroiditis, are younger and have smaller tumors than patients with PTC.
Mosso
Lorena
L
Departamento de Endocrinología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. mosso@.med.puc.cl
Velasco
Soledad
S
Salazar
Iván
I
Solar
Antonieta
A
González
Hernán
H
Cardona
Belinda
B
Fardella
Carlos
C
González
Gilberto
G
López
José Manuel
JM
Rodríguez
José Adolfo
JA
Cruz
Francisco
F
Arteaga
Eugenio
E
D000328:Adult; D000367:Age Factors; D018276:Carcinoma, Medullary / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002677:Chile; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery