title: Genetic dissection of cytonuclear epistasis in line crosses.
abstract: Dissection of cytonuclear interactions is fundamentally important for understanding the genetic architecture of complex traits. Here we propose a mating design based on reciprocal crosses and extend the existing QTL mapping method to evaluate the contribution of cytoplasm and QTL x cytoplasm interactions to the phenotypic variation. Efficiency of the design and method is demonstrated via simulated data.
authors.affiliation: Jiangsu Provincial Key Laboratory of Crop Genetics and Physiology, Key Laboratory of Plant Functional Genomics of Ministry of Education, Yangzhou University, Yangzhou 225009, China.
authors.forename: Zaixiang
authors.initials: Z
authors.lastname: Tang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wang
authors.forename: Zhiqiu
authors.initials: Z
authors.lastname: Hu
authors.forename: Zefeng
authors.initials: Z
authors.lastname: Yang
authors.forename: Chenwu
authors.initials: C
authors.lastname: Xu
mesh_terms: D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism*; D002874:Chromosome Mapping; D003198:Computer Simulation; D003433:Crosses, Genetic; D003593:Cytoplasm / Q000378:metabolism*; D004843:Epistasis, Genetic; D005260:Female; D014644:Genetic Variation; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics; D012641:Selection, Genetic