Relationships of urinary adrenal steroids at age 8 years with birth weight, postnatal growth, blood pressure, and glucose metabolism.
BACKGROUND
Overactivity of the hypothalamic-pituitary-adrenal axis through a program set by early growth patterns is hypothesized to lead to central obesity, insulin resistance, and hypertension. We therefore examined links between adrenal steroid production and birth weight, rapid early growth, and body mass index (BMI), blood pressure, waist circumference, and resistance to insulin in early childhood through the action of adrenal steroids.


METHODS
Timed overnight urine samples were collected in 461 children from a large representative birth cohort. In total 244 boys and 188 girls aged 8.2-8.4 yr completed the protocol. The excretion rates of individual steroids were measured to determine total androgen and cortisol metabolites. Indices of activity of 5alpha-androgen reduction of androgens and cortisol metabolites and 11beta-hydroxy steroid dehydrogenase activity were calculated.


RESULTS
In both boys and girls, total urinary androgen and cortisol metabolites were positively related to current height, weight, BMI, and waist circumference. Girls had higher urine androgen metabolite levels and 5alpha-androgen indexes than boys, and in girls higher androgen metabolite excretion was associated with lower birth weight and faster postnatal weight gain. After adjustment for current BMI, total cortisol metabolites and 11beta-hydroxy steroid dehydrogenase index were not related to birth weight or postnatal weight gain in either sex.


CONCLUSIONS
These data confirm early growth associations in this cohort seen with plasma levels of adrenal androgens at age 8 yr, at least in girls. Larger studies and follow-up during puberty are needed to exclude the possibility of programming of cortisol metabolism by early growth.
Honour
John W
JW
Clinical Biochemistry, University College London Hospitals, 60 Whitfield Street, London W1T 4EU, United Kingdom. john.honour@uclh.nhs.uk
Jones
Richard
R
Leary
Sam
S
Golding
Jean
J
Ong
Ken K
KK
Dunger
David B
DB
D000304:Adrenal Cortex Function Tests; D000305:Adrenal Cortex Hormones / Q000652:urine*; D000728:Androgens / Q000097:blood; D001724:Birth Weight / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002648:Child; D004739:England / Q000453:epidemiology; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006128:Growth / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D012016:Reference Values; D012727:Sex Characteristics; D013256:Steroids / Q000652:urine*
D000305:Adrenal Cortex Hormones; D000728:Androgens; D013256:Steroids; D005947:Glucose