Beyond sports-doping headlines: the science of laboratory tests for performance-enhancing drugs.
This primer on urine analysis in sports-doping control is an overview with an emphasis on the main analytical chemistry technologies in use: gas chromatography-mass spectrometry (GC-MS), liquid chromatography-tandem mass spectrometry (LC-MS-MS), isotope ratio mass spectrometry detection of exogenous testosterone use, and isoelectric focusing detection of recombinant erythropoietin (EPO) use. Included are graphic examples of GC-MS selected ion monitoring and full scan, LC-MS-MS, and EPO test electropherogram data; a list of common acronyms; and answers to questions frequently asked about tampering and test accuracy.
Hatton
Caroline K
CK
UCLA Olympic Laboratory, University of California at Los Angeles, 2122 Granville Avenue, Los Angeles, CA 90025, USA. ckhatton@aol.com
D000293:Adolescent; D004300:Doping in Sports; D006801:Humans; D013178:Sports Medicine; D015813:Substance Abuse Detection / Q000379:methods*