Salutary effects of Corydalis yanhusuo extract on cardiac hypertrophy due to pressure overload in rats.
We have evaluated the effects of an alcohol extract from the rhizome of Corydalis yanhusuo W. T. (CY), a well-known traditional Chinese medicinal herb, on pressure-overloaded cardiac hypertrophy induced by transverse abdominal aorta constriction (TAAC) in rats. Rats were given vehicle or CY extract (200 or 50 mg kg(-1) per day) from the second week after induction of pressure overload, for a period of 7 weeks. Haemodynamic parameters, relative heart weight and myocyte cross-sectional area were measured in each group. We also estimated left ventricular (LV) collagen volume fraction (CVF) using Masson trichrome staining, and type I collagen expression by Western blot assay. Chronic TAAC caused notable cardiac hypertrophy and heart dysfunction. Significant collagen deposition and greater type I collagen expression were found in model control rats. These changes were not significantly reversed after treatment with 50 mg kg(-1) CY, whereas 200 mgkg(-1) significantly improved heart function and prevented cardiac hypertrophy, with parallel reductions in myocardial fibrosis, as evidenced by reduced LV CVF and reduced levels of type I collagen. In conclusion, chronic treatment of rats with CY extract attenuated development of cardiac hypertrophy.
Wen
Chengping
C
Zhejiang Traditional Chinese Medical University, Binwen Road, Binjiang District, Hangzhou 310053, PR China.
Wu
Limao
L
Ling
Haiyun
H
Li
Lianda
L
D000818:Animals; D001012:Aorta, Abdominal; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000188:drug therapy* / Q000503:physiopathology; D003094:Collagen / Q000378:metabolism; D024042:Collagen Type I / Q000378:metabolism; D031311:Corydalis / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004719:Endomyocardial Fibrosis / Q000188:drug therapy; D015870:Gene Expression; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008516:Medicine, Chinese Traditional; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy*
D024042:Collagen Type I; D010936:Plant Extracts; D003094:Collagen