[Influence of enalapryl on vasomotor reactions of rats with chronic deficiency of dopamine in the mesencephalo-striatal system].
The results of experiments on isolated preparations of aorta and portal vein of rats with chronic deficiency of mesencephalo-striatal dopamine have shown that endothelium-dependent reactions of dilatation were inhibited. If rats with dopamine deficiency received enalapryl (20 mg/kg) these reactions partly recovered. A possible conclusion may be that in conditions of cerebral dopamine deficiency the functional state of endothelium got worse, and endothelium-dependent dilatation of vascular smooth muscles was inhibited. The use of inhibitor of angiotensin-converting enzyme enalapryl resulted in a significant restoration of the above vascular reactions.
Talanov
S O
SO
Tkachenko
M M
MM
Baziliuk
O V
OV
Stepanenko
L H
LH
Sahach
V F
VF
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D003342:Corpus Striatum / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000172:deficiency*; D004656:Enalapril / Q000494:pharmacology*; D066298:In Vitro Techniques; D008636:Mesencephalon / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D020734:Parkinsonian Disorders / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D011921:Rats, Inbred WKY; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
D014662:Vasoconstrictor Agents; D004656:Enalapril; D004298:Dopamine; D009638:Norepinephrine