HDL-inflammatory index correlates with poor outcome in hemodialysis patients.
Oxidative stress and cardiovascular disease are risk factor of patients with chronic kidney disease (CKD) on maintenance hemodialysis. We used the fluorescence of low-density lipoprotein as an index of its proinflammatory potential to examine any role that high-density lipoprotein (HDL) might have in promoting this effect. The total body fat of the patients was measured by means of near-infrared interactance and their quality of life by means of SF36 questionnaires. In 189 randomly selected patients, followed for 30 months, HDL was found to be significantly anti-inflammatory but with a large standard deviation. Fully 17% of the patients had a decidedly proinflammatory index along with inferior SF36 scores. The patients were divided into 10% increments of total body fat percentages up to 40%. HDL was found to be progressively proinflammatory the higher the body fat content. Patients with a higher HDL proinflammatory index had a higher 30-month adjusted hazard ratio for death than those whose HDL were seen to be anti-inflammatory. Our findings suggest an important role of inflammatory HDL in patients with CKD leading to poor outcome.
Kalantar-Zadeh
K
K
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA. kamkal@ucla.edu
Kopple
J D
JD
Kamranpour
N
N
Fogelman
A M
AM
Navab
M
M
D015415:Biomarkers / Q000097:blood; D001823:Body Composition / Q000502:physiology; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D007249:Inflammation; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000097:blood* / Q000175:diagnosis / Q000628:therapy*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D011379:Prognosis; D011788:Quality of Life; D006435:Renal Dialysis; D012307:Risk Factors; D016896:Treatment Outcome
D015415:Biomarkers; D008075:Lipoproteins, HDL