title: How we treat: management of life-threatening primary postpartum hemorrhage with a standardized massive transfusion protocol.
abstract: Management of massive, life-threatening primary postpartum hemorrhage in the labor and delivery service is a challenge for the clinical team and hospital transfusion service. Because severe postpartum obstetrical hemorrhage is uncommon, its occurrence can result in emergent but variable and nonstandard requests for blood products. The implementation of a standardized massive transfusion protocol for the labor and delivery department at our institution after a maternal death caused by amniotic fluid embolism is described. This guideline was modeled on a existing protocol used by the trauma service mandating emergency release of 6 units of group O D- red cells (RBCs), 4 units of fresh frozen or liquid plasma, and 1 apheresis unit of platelets (PLTs). The 6:4:1 fixed ratio of uncrossmatched RBCs, plasma, and PLTs allows the transfusion service to quickly provide blood products during the acute phase of resuscitation and allows the clinical team to anticipate and prevent dilutional coagulopathy. The successful management of three cases of massive primary postpartum hemorrhage after the implementation of our new massive transfusion protocol in the maternal and fetal medicine service is described.
authors.affiliation: Department of Pathology, Stanford University Medical Center, Stanford, California, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Burtelow
authors.forename: Ed
authors.initials: E
authors.lastname: Riley
authors.forename: Maurice
authors.initials: M
authors.lastname: Druzin
authors.forename: Magali
authors.initials: M
authors.lastname: Fontaine
authors.forename: Maurene
authors.initials: M
authors.lastname: Viele
authors.forename: Lawrence Tim
authors.initials: LT
authors.lastname: Goodnough
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D001803:Blood Transfusion / Q000592:standards*; D001831:Body Temperature; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D008875:Middle Aged; D006473:Postpartum Hemorrhage / Q000503:physiopathology / Q000628:therapy*; D011247:Pregnancy