title: Long lasting pure freezing of gait preceding progressive supranuclear palsy: a clinicopathological study.
abstract: Primary progressive freezing of gait (PPFG) is the term used to designate an uncommon condition featuring freezing of gait with frequent falls, without bradykinesia, rigidity or tremor, and unresponsive to levodopa. There are very few pathological reports of patients with PPFG in the literature. We report on 2 patients (one with pathological confirmation) diagnosed initially as PPFG and evolving into clinically defined progressive supranuclear palsy (PSP) more than 10 years after onset of symptoms. These 2 cases suggest that PPFG can represent the initial manifestation of a neurodegenerative disease, such as PSP, rather than a differentiated nosological entity.
authors.affiliation: Servei de Neurologia, Institut Clínic de Neurociències, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain.
authors.forename: Yaroslau
authors.initials: Y
authors.lastname: Compta
authors.forename: Francesc
authors.initials: F
authors.lastname: Valldeoriola
authors.forename: Eduardo
authors.initials: E
authors.lastname: Tolosa
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Rey
authors.forename: María José
authors.initials: MJ
authors.lastname: Martí
authors.forename: Josep
authors.initials: J
authors.lastname: Valls-Solé
mesh_terms: D000058:Accidental Falls; D000368:Aged; D001253:Astrocytes / Q000473:pathology; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D050483:Dopamine Plasma Membrane Transport Proteins / Q000502:physiology; D005260:Female; D020233:Gait Disorders, Neurologic / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D016874:Neurofibrillary Tangles / Q000473:pathology; D009460:Neurologic Examination; D019581:Neuropil / Q000473:pathology; D009662:Nortropanes; D009836:Oligodendroglia / Q000473:pathology; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis* / Q000473:pathology; D024801:Tauopathies / Q000175:diagnosis / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D007457:Iodine Radioisotopes; D009662:Nortropanes; C519528:ioflupane