title: Flow-induced platelet activation and damage accumulation in a mechanical heart valve: numerical studies.
abstract: A model for platelet activation based on the theory of damage, incorporating cumulative effects of stress history and past damage (senescence) was applied to a three-dimensional (3-D) model of blood flow through a St. Jude Medical (SJM) bileaflet mechanical heart valve (MHV), simulating flow conditions after implantation. The calculations used unsteady Reynolds-averaged Navier-Stokes formulation with non-Newtonian blood properties. The results were used to predict platelet damage from total stress (shear, turbulent, deformation), and incorporate the contribution of repeated passages of the platelets along pertinent trajectories. Trajectories that exposed the platelets to elevated levels of stress around the MHV leaflets and led them to entrapment within the complex 3-D vortical structures in the wake of the valve significantly enhanced platelet activation. This damage accumulation model can be used to quantify the thrombogenic potential of implantable cardiovascular devices, and indicate the problem areas of the device for improving their designs.
authors.affiliation: Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY11794-8181, USA.
authors.forename: Yared
authors.initials: Y
authors.lastname: Alemu
authors.forename: Danny
authors.initials: D
authors.lastname: Bluestein
mesh_terms: D001783:Blood Flow Velocity; D003198:Computer Simulation; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation*; D018056:Hemorheology; D006801:Humans; D021621:Imaging, Three-Dimensional; D008955:Models, Cardiovascular; D015539:Platelet Activation; D011474:Prosthesis Design; D011475:Prosthesis Failure; D011673:Pulsatile Flow; D013314:Stress, Mechanical; D013927:Thrombosis / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D013997:Time Factors