Time and length scales of autocrine signals in three dimensions.
A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.
Coppey
Mathieu
M
Department of Chemical Engineering and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
Berezhkovskii
Alexander M
AM
Sealfon
Stuart C
SC
Shvartsman
Stanislav Y
SY
D019898:Autocrine Communication / Q000276:immunology / Q000502:physiology*; D055592:Biophysical Phenomena; D001703:Biophysics; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology; D007372:Interferons / Q000502:physiology; D008024:Ligands; D008954:Models, Biological; D019899:Paracrine Communication / Q000276:immunology / Q000502:physiology
D008024:Ligands; D007372:Interferons