title: [Association between glutathione peroxidase levels and clinical manifestations of dengue].
abstract: BACKGROUND
  Glutathione peroxidase (GP) can be used as a marker of oxidative stress in infectious diseases.
  
  
  OBJECTIVE
  To evaluate the association between the levels of glutathione peroxidase (GP) and the manifestations and complications of dengue.
  
  
  METHODS
  Between April 2003 and December 2004, 161 patients with dengue were prospectively evaluated. In the first evaluation, within 48 and 96 hours of disease onset, a plasma sample was obtained to measure the GP levels. The association between GP levels, clinical manifestations and complications was evaluated during the follow up.
  
  
  RESULTS
  Mean GP values were 1198 U/L (95% confidence interval 1089-1306). Values greater than 1200 U/L were associated with headache, arthralgias and increased heart rate. There was a negative association between GP levels and serum triglycerides. During follow up, patients with GP >1200 U/L had a higher frequency of spontaneous hemorrhages. In a logistic regression analysis arthralgias, fever and increased heart rate, were independently associated with levels >1200 U/L.
  
  
  CONCLUSIONS
  GP levels was associated to some of the manifestations of dengue. This finding suggests that the intensity of oxidative stress can influence the clinical presentation of dengue.
authors.affiliation: Grupo de Epidemiología Clínica, Centro de Investigaciones Epidemiológicas, Universidad Industrial de Santander, Bucaramanga, Colombia.
authors.forename: Elsa Marina
authors.initials: EM
authors.lastname: Rojas
authors.forename: Fredi Alexander
authors.initials: FA
authors.lastname: Díaz-Quijano
authors.forename: Carolina
authors.initials: C
authors.lastname: Coronel-Ruiz
authors.forename: Ruth Aralf
authors.initials: RA
authors.lastname: Martínez-Vega
authors.forename: Ernesto
authors.initials: E
authors.lastname: Rueda
authors.forename: Luis Angel
authors.initials: LA
authors.lastname: Villar-Centeno
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002648:Child; D003105:Colombia / Q000453:epidemiology; D003715:Dengue / Q000150:complications / Q000201:enzymology* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D011446:Prospective Studies; D019595:Severe Dengue / Q000150:complications / Q000201:enzymology / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D005979:Glutathione Peroxidase