Platinum-catalyzed hydrofunctionalization of unactivated alkenes with carbon, nitrogen and oxygen nucleophiles.
The transition metal-catalyzed addition of the X-H bond of a carbon, nitrogen or oxygen nucleophile across the C[double bond]C bond of an unactivated alkene (hydrofunctionalization) represents an attractive, atom-economical approach to the synthesis of carbocyclic and heterocyclic molecules and for the elaboration of ethylene and 1-alkenes. We have developed a family of Pt(II)-catalyzed protocols for the inter- and intramolecular hydrofunctionalization of unactivated alkenes with a range of H-X nucleophiles including beta-diketones, indoles, amines, carboxamides and alcohols. These transformations display good functional group compatibility, low moisture sensitivity, and often good generality.
Liu
Cong
C
Family Science Center, Duke University, Durham, North Carolina 27708, USA.
Bender
Christopher F
CF
Han
Xiaoqing
X
Widenhoefer
Ross A
RA
D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D010984:Platinum / Q000737:chemistry*
D000475:Alkenes; D006571:Heterocyclic Compounds; D010984:Platinum; D002244:Carbon; D009584:Nitrogen; D010100:Oxygen