Sex and diet affect the behavioral response of rats to chronic mild stressors.
To investigate the interaction between sex, stressors, and dietary choice in rats, a preferred diet under the influence of chronic mild stressors was empirically determined to consist of soybeans and cookies in addition to lab chow. This preferred mixed diet was then tested for its influence on several behavioral tests at the end of prolonged exposure to the potential stressors. Rats of both sexes decreased their frequency of rearing but increased their attention to novelty in response to stressors. In the elevated plus maze, diet interacted with exposure to stressors to influence time spent in the open arm in females but not males. In the forced swim test, females but not males fed the mixed diet showed increased immobility, whether exposed to stressors or not. Finally, females but not males showed a differential effect of diet under stressors on the sucrose preference test, but this result was confounded by estrus cycling, demonstrating the importance of this factor in analyzing behavior in females. These results suggest that male and female rats differ in their susceptibility to the behavioral-modifying influences of stressors. And to the extent that diet serves as a coping mechanism, it does so differently in males and females.
Liang
Shuwen
S
Department of Biological Sciences, University of Texas at El Paso, 500 W. University Avenue, El Paso, Texas 79968, United States. liangshuwen@hotmail.com
Byers
Donna M
DM
Irwin
Louis N
LN
D000222:Adaptation, Physiological; D000223:Adaptation, Psychological; D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000150:complications / Q000523:psychology; D002755:Choice Behavior; D002908:Chronic Disease; D004195:Disease Models, Animal; D004435:Eating / Q000523:psychology; D005106:Exploratory Behavior; D005247:Feeding Behavior / Q000523:psychology*; D005260:Female; D005518:Food Preferences / Q000523:psychology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D013315:Stress, Psychological / Q000150:complications / Q000523:psychology*; D013649:Taste