Dyslipidemia and H pylori in gastric xanthomatosis.
OBJECTIVE
To investigate the relationship among gastric xanthomatosis (GX), H pylori, dyslipidemia, and gastritis in Korea, a well-known H pylori endemic area.


METHODS
A total of 771 patients who had undergone gastroduodenoscopy by one endoscopist were included in this study. Among them, 54 patients with GX were assessed for H pylori infection and their endoscopic characteristics and serum lipid profiles. The findings were compared with 54 age- and sex-matched control subjects without GX.


RESULTS
The prevalence of GX was 7% (54/771) with no sex difference. GX was mainly single (64.8%) and located in the antrum (53.7%). The mean diameter was 7 +/- 3 mm. Mean body mass index (BMI) of patients with GX was 23.1 +/- 2.8 and no one was above 30. Compared with the controls, lipid profiles of GX group showed significantly lower HDL-cholesterol (48.8 +/- 12.3 vs 62.9 +/- 40.5, P = 0.028) and higher LDL-cholesterol (112.9 +/- 29.9 vs 95.9 +/- 22.4, P = 0.032). The level of total serum cholesterol, triglyceride and the existence of dyslipoproteinemia were not related to the presence of GX. However, GX showed a close relationship with endoscopically determined atrophic gastritis and histologic severity (24/53, 44.4% vs 8/54, 14.8%, P = 0.0082). H pylori infection and bile reflux gastritis were not significantly related with GX.


CONCLUSIONS
The prevalence of GX is 7% and it may be an increasing entity in Korea. Moreover, dyslipidemia and atrophic gastritis are found to be related to GX, but H pylori infection is not.
Yi
Sun Young
SY
Department of Internal Medicine, School of Medicine, Ewha Womans University, Yangcheon-Gu Mok-Dong 911-1, Seoul, South Korea. syy@ewha.ac.kr
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D016022:Case-Control Studies; D004384:Duodenoscopy; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology*; D005260:Female; D005757:Gastritis, Atrophic / Q000453:epidemiology* / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D007723:Korea; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011706:Pyloric Antrum / Q000473:pathology; D012720:Severity of Illness Index; D013272:Stomach Diseases / Q000097:blood / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D014973:Xanthomatosis / Q000453:epidemiology* / Q000473:pathology
D008055:Lipids