title: Key clinical issues in renal cancer: a challenge for proteomics.
abstract: Renal cancer has many clinical challenges which proteomics is ideally placed to address. The issues cover all aspects of the disease including diagnosis, prognosis, treatment selection and monitoring to detect metastatic disease. In all cases novel biomarkers would considerably help in clinical management and with the relative resistance to conventional chemotherapy and radiotherapy, a better understanding of the underlying pathogenesis may contribute to the much needed development of novel therapeutic targets and the better use of promising new anti-angiogenic treatments. This review briefly highlights some of the clinical issues and describes proteomics-based approaches generally, before focussing on reviewing the proteomic studies to date in this area.
authors.affiliation: Cancer Research UK Clinical Centre, St James's University Hospital, Leeds LS9 7TF, UK. r.banks@leeds.ac.uk
authors.forename: Rosamonde E
authors.initials: RE
authors.lastname: Banks
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Craven
authors.forename: Patricia
authors.initials: P
authors.lastname: Harnden
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Madaan
authors.forename: Adrian
authors.initials: A
authors.lastname: Joyce
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Selby
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology; D014408:Biomarkers, Tumor / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D045744:Cell Line, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D008495:Medical Oncology / Q000379:methods; D009363:Neoplasm Proteins / Q000032:analysis* / Q000378:metabolism; D011379:Prognosis; D040901:Proteomics / Q000379:methods*; D014572:Urology / Q000379:methods
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins