Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1.
The regulation of tissue perfusion is a major mechanism by which oxygen homeostasis is maintained. Hypoxia-inducible factor 1 (HIF-1) is a transcriptional regulator that mediates adaptive responses to reduced partial pressure of O(2) in all metazoan species. In mammals, HIF-1 promotes angiogenesis, arteriogenesis and vasculogenesis through the production of multiple angiogenic growth factors in ischaemic tissue and by cell-autonomous effects on endothelial cells and bone marrow-derived angiogenic cells. Administration of viral vectors encoding constitutively active forms of the HIF-1alpha subunit results in increased tissue perfusion in animal models of ischaemic cardiovascular disease.
Semenza
Gregg L
GL
Vascular Biology Program and Institute for Cell Engineering, Departments of Pediatrics, Medicine, Oncology and Radiation Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. gsemenza@jhmi.edu
D000818:Animals; D001775:Blood Circulation / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology; D004195:Disease Models, Animal; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000502:physiology; D010100:Oxygen / Q000378:metabolism*
D051793:Hypoxia-Inducible Factor 1; D010100:Oxygen