Preparation, characterization, and controlled release of novel nanoparticles based on MMA/beta-CD copolymers.
A series of random copolymers with different beta-cyclodextrin contents were synthesized by radical copolymerization of MMA with a monovinyl beta-CD monomer. The copolymers were characterized with IR spectroscopy, elemental analysis, DSC, and TGA. Based on these copolymers, their nanoparticles were prepared by using DMF, water, and acetone as solvents. Aqueous dispersions of the nanoparticles were further obtained by dialysis against water. Zetasizer Nano-ZS dynamic light scattering and transmission electron microscopy were employed to characterize the nanoparticles. Using camptothecin as a model drug molecule, the encapsulation efficiency and release behavior of the nanoparticles were investigated.
Liu
Yu-Yang
YY
Department of Applied Chemistry, Northwestern Polytechnical University, Xi'an, 710072, China. yyliu666@yahoo.com.cn
Yu
Yu
Y
Zhang
Guo-Bin
GB
Tang
Min-Feng
MF
D002152:Calorimetry, Differential Scanning; D002166:Camptothecin / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D020366:Methylmethacrylate / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D013055:Spectrophotometry, Infrared; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry*
D003692:Delayed-Action Preparations; D047392:beta-Cyclodextrins; D020366:Methylmethacrylate; C031215:betadex; D002166:Camptothecin