Cardiac magnetic resonance imaging in small rodents using clinical 1.5 T and 3.0 T scanners.
Cardiac magnetic resonance (CMR) imaging can provide noninvasive, high resolution images of heart anatomy, viability, perfusion, and function. However, the adoption of clinical CMR imaging protocols for small rodents has been limited due to the small heart size and rapid heart rates. Therefore, most CMR studies in small rodents have been performed on non-clinical, high-field MR magnets. Because such high-field systems are not readily available at most institutions, the technical aspects that are needed to perform CMR on clinical 1.5 T and 3.0 T MR scanners are presented in this paper. Equipment requirements are presented, and a comprehensive description of the methods needed to complete a CMR exam including the animal preparation, imaging, and image analysis are discussed. In addition, the advanced applications of myocardial tagging and delayed-contrast-enhanced imaging are reviewed for the assessment of regional contractile function and myocardial viability, respectively.
Gilson
Wesley D
WD
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, 601 N. Caroline Street, Box 0845, JHOC 4240, Baltimore, MD 21287, USA. gilson@mri.jhu.edu
Kraitchman
Dara L
DL
D000818:Animals; D049628:Body Size; D003287:Contrast Media / Q000008:administration & dosage; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006321:Heart / Q000033:anatomy & histology* / Q000503:physiopathology; D007089:Image Enhancement / Q000295:instrumentation / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000191:economics / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000191:economics / Q000295:instrumentation* / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000191:economics / Q000295:instrumentation / Q000379:methods; D051379:Mice; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D012377:Rodentia / Q000033:anatomy & histology* / Q000378:metabolism
D003287:Contrast Media; D019786:Gadolinium DTPA