title: Quinic acid esters from Pluchea indica with collagenase, MMP-2 and MMP-9 inhibitory activities.
abstract: Investigation of collagenase inhibitory natural components afforded two quinic acid esters (1 and 2) and quercetin (3) from the leaves of Pluchea indica (Compositae). Of these, compounds 1 and 2 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 10 microm, and 1 showed matrix metalloproteinase (MMP)-2 and -9 inhibitory activity (IC(50)) at 2.5 and 6.4 microm, respectively.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohtsuki
authors.forename: Emiko
authors.initials: E
authors.lastname: Yokosawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Koyano
authors.forename: Srisomporn
authors.initials: S
authors.lastname: Preeprame
authors.forename: Thaworn
authors.initials: T
authors.lastname: Kowithayakorn
authors.forename: Shinobu
authors.initials: S
authors.lastname: Sakai
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Toida
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004952:Esters; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011801:Quinic Acid / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004952:Esters; D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts; D011801:Quinic Acid