title: Movements execution in amnestic mild cognitive impairment and Alzheimer's disease.
abstract: We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer's Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunction in early AD could represent the transition from aMCI to AD.
authors.affiliation: Laboratory of Epidemiology and Psychology of Aging and Dementia, Section of Neurology, Department of Clinical Neuroscience, University of Palermo, Palermo, Italy. rosolino.camarda@unipa.it
authors.forename: Rosolino
authors.initials: R
authors.lastname: Camarda
authors.forename: Cecilia
authors.initials: C
authors.lastname: Camarda
authors.forename: Roberto
authors.initials: R
authors.lastname: Monastero
authors.forename: Silvia
authors.initials: S
authors.lastname: Grimaldi
authors.forename: Lawrence K C
authors.initials: LK
authors.lastname: Camarda
authors.forename: Carmela
authors.initials: C
authors.lastname: Pipia
authors.forename: Carlo
authors.initials: C
authors.lastname: Caltagirone
authors.forename: Massimo
authors.initials: M
authors.lastname: Gangitano
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology*; D000647:Amnesia / Q000175:diagnosis / Q000453:epidemiology*; D001696:Biomechanical Phenomena; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall; D009069:Movement Disorders / Q000175:diagnosis / Q000453:epidemiology*; D009483:Neuropsychological Tests; D011930:Reaction Time; D012720:Severity of Illness Index