title: Baseline mannose binding lectin levels may not predict infection among children with leukemia.
abstract: We measured baseline serum mannose binding lectin (MBL) levels in 91 patients with childhood leukemia to determine their predictive value for the development of febrile neutropenia or specific infections. Median MBL levels did not differ significantly between patients who developed febrile neutropenia, bacterial infection, or disseminated fungal infection and those who did not. In addition, low MBL levels were not associated with an increased cumulative incidence of infection or with a shorter time to first infection. This preliminary study suggests that baseline MBL levels may not be clinically useful to identify pediatric leukemia patients who are at increased risk of infection. Additional studies are required to determine whether serial MBL measurements may be valuable for this purpose.
authors.affiliation: Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. jeffrey.rubnitz@stjude.org
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Rubnitz
authors.forename: Scott C
authors.initials: SC
authors.lastname: Howard
authors.forename: Jennifer
authors.initials: J
authors.lastname: Willis
authors.forename: Ching-Hon
authors.initials: CH
authors.lastname: Pui
authors.forename: Stanley
authors.initials: S
authors.lastname: Pounds
authors.forename: Randall T
authors.initials: RT
authors.lastname: Hayden
mesh_terms: D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005334:Fever / Q000209:etiology; D006801:Humans; D007239:Infections / Q000097:blood / Q000175:diagnosis*; D007938:Leukemia / Q000097:blood* / Q000150:complications* / Q000382:microbiology*; D037601:Mannose-Binding Lectin / Q000097:blood*; D009503:Neutropenia / Q000209:etiology; D011237:Predictive Value of Tests
chemical_list: D037601:Mannose-Binding Lectin