title: Treatment of wild-type gastrointestinal stromal tumor (WT-GIST) with imatinib and sunitinib.
abstract: We report a rare case of advanced, metastatic gastrointestinal stromal tumor (GIST) in a young female. Molecular analysis of the tumor revealed wild-type (WT) KIT and platelet derived growth factor receptor alpha (PDGFRA) gene status with no mutations characteristic of adult GIST. Despite this she had clinical benefit and evidence of radiological response to sequential treatment with the tyrosine kinase inhibitors imatinib and sunitinib.
authors.affiliation: Oncology Department, Addenbrooke's Hospital, Cambridge, UK. mjm16@cam.ac.uk
authors.forename: Matthew
authors.initials: M
authors.lastname: Murray
authors.forename: Helen
authors.initials: H
authors.lastname: Hatcher
authors.forename: Flora
authors.initials: F
authors.lastname: Jessop
authors.forename: Denise
authors.initials: D
authors.lastname: Williams
authors.forename: Nicholas
authors.initials: N
authors.lastname: Carroll
authors.forename: Ramesh
authors.initials: R
authors.lastname: Bulusu
authors.forename: Ian
authors.initials: I
authors.lastname: Judson
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001549:Benzamides; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D000068877:Imatinib Mesylate; D007211:Indoles / Q000008:administration & dosage; D010879:Piperazines / Q000008:administration & dosage; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D011743:Pyrimidines / Q000008:administration & dosage; D011758:Pyrroles / Q000008:administration & dosage; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics; D000077210:Sunitinib
chemical_list: D001549:Benzamides; D007211:Indoles; D010879:Piperazines; D011743:Pyrimidines; D011758:Pyrroles; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit; D020796:Receptor, Platelet-Derived Growth Factor alpha; D000077210:Sunitinib