YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008.
In the course of screening for drugs that suppress the Ca(2+)-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca(2+)-signaling. A novel pyrano-pyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca(2+)-induced growth inhibition of the Saccharomyces cerevisiae (Deltazds1Deltasyr1) mutant.
Koizumi
Fumito
F
BioFrontier Laboratories, Kyowa Hakko Kogyo Co. Ltd., Tokyo, Japan.
Fukumitsu
Naomi
N
Zhao
Jinrong
J
Chanklan
Ruthada
R
Miyakawa
Tokichi
T
Kawahara
Shoko
S
Iwamoto
Shin
S
Suzuki
Makoto
M
Kakita
Shingo
S
Rahayu
Endang S
ES
Hosokawa
Seijiro
S
Tatsuta
Kuniaki
K
Ichimura
Michio
M
D000935:Antifungal Agents / Q000494:pharmacology*; D020013:Calcium Signaling / Q000187:drug effects*; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005670:Fusarium; D006801:Humans; D011714:Pyrans / Q000494:pharmacology*; D011728:Pyridones / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
D000935:Antifungal Agents; D011714:Pyrans; D011728:Pyridones; C524346:YCM 1008A