title: [Clinical features of 17 patients with familial non medullary thyroid carcinoma].
abstract: BACKGROUND
  Papillary thyroid carcinoma can have familial aggregation.
  
  
  OBJECTIVE
  To compare retrospectively familial non medullary thyroid carcinoma (FNMTC) with sporadic papillary thyroid carcinoma (PTC).
  
  
  METHODS
  Retrospective analysis of medical records of patients with thyroid carcinoma. An index case was defined as a subject with the diagnosis of differentiated thyroid carcinoma with one or more first degree relatives with the same type of cancer. Seventeen such patients were identified and were compared with 352 subjects with PTC.
  
  
  RESULTS
  The most common affected relatives were sisters. Patients with FNMTC were younger than those with PTC. No differences were observed in gender, single or multiple foci, thyroid capsule involvement, surgical border involvement, number of affected lymph nodes and coexistence of follicular hyperplasia. Patients with FNMTC had smaller tumors and had a nine times more common association with lymphocytic thyroiditis. Five patients with FNMTC had local recurrence during 4.8 years of follow up.
  
  
  CONCLUSIONS
  Patients with FNMTC commonly have an associated chronic thyroiditis, are younger and have smaller tumors than patients with PTC.
authors.affiliation: Departamento de Endocrinología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. mosso@.med.puc.cl
authors.forename: Lorena
authors.initials: L
authors.lastname: Mosso
authors.forename: Soledad
authors.initials: S
authors.lastname: Velasco
authors.forename: Iván
authors.initials: I
authors.lastname: Salazar
authors.forename: Antonieta
authors.initials: A
authors.lastname: Solar
authors.forename: Hernán
authors.initials: H
authors.lastname: González
authors.forename: Belinda
authors.initials: B
authors.lastname: Cardona
authors.forename: Carlos
authors.initials: C
authors.lastname: Fardella
authors.forename: Gilberto
authors.initials: G
authors.lastname: González
authors.forename: José Manuel
authors.initials: JM
authors.lastname: López
authors.forename: José Adolfo
authors.initials: JA
authors.lastname: Rodríguez
authors.forename: Francisco
authors.initials: F
authors.lastname: Cruz
authors.forename: Eugenio
authors.initials: E
authors.lastname: Arteaga
mesh_terms: D000328:Adult; D000367:Age Factors; D018276:Carcinoma, Medullary / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002677:Chile; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery