[Extended suicidal poisoning with carbamazepine and phenothiazine derivatives].
Two cases (woman and man) of the extended suicidal poisonings with carbamazepine and phenothiazine derivatives are presented. Drug's blood concentrations during poisoning were monitored. We examine correlation between patient's general status and the drug's blood concentrations, carbamazepine and phenothiazine derivatives interaction due to young, healthy people who received no earlier treatment.


METHODS
blood samples for toxicological examinations were collected at 0, 12, 24 and 48 hours after admission. Carbamazepine was determined using FPIA method and phenothiazines derivatives by HPLC-DAD. The highest blood concentrations were for carbamazepine: 30.92 mg/l (woman) and 20.95 ng/ml (man); for phenothiazine derivatives: 927 ng/ml (woman) and 733 ng/ ml (man).


CONCLUSIONS
In both cases severe central nervous depression was observed due to summed action of the drugs. Sex and individual differences in cytochromes activities should have influence to carbamazepine metabolism and faster elimination time in woman. In the case of phenothiazine derivatives faster elimination time in man was observed. The differences in elimination times between compared drugs confirm their different metabolic routes.
Hydzik
Piotr
P
Oddzial (Kliniczny) Toksykologii i Chorób Srodowiskowych, WSS im. L. Rydygiera w Krakowie. piodzik@poczta.onet.pl
Gomółka
Ewa
E
Wilimowska
Jolanta
J
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000097:blood / Q000652:urine; D002220:Carbamazepine / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning* / Q000652:urine; D002492:Central Nervous System Depressants / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning / Q000652:urine; D062787:Drug Overdose; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D010640:Phenothiazines / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning* / Q000652:urine; D012720:Severity of Illness Index; D012737:Sex Factors; D013406:Suicide, Attempted; D016896:Treatment Outcome
D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D010640:Phenothiazines; D002220:Carbamazepine; C031637:phenothiazine