title: The prevalence of drugs in carbon monoxide-related deaths: a retrospective study, 2000-2003.
abstract: The objective of this study was to review demographic characteristics and drugs detected in carbon monoxide (CO)-related deaths from cases received by the Office of the Cuyahoga County Coroner in Cleveland, Ohio, from 2000-2003. Postmortem reports were reviewed, and decedents for which CO was listed as the cause of death were included. The data were compiled into 3 groups according to the official coroner's verdict as to the manner of death: accident, suicide, and homicide. Included in this study were 122 cases: 84 (69%) accidental, 31 (25%) suicide, and 7 (6%) homicide. Accident decedents were typically white males, aged 40-59 years, residing in Cleveland. Suicide decedents were also middle-aged, white males but residing in the suburbs. Homicide decedents under the age of 6 were characteristically black (N=2), while decedents over the age of 39 were predominately white (N=3). Carboxyhemoglobin (COHb) levels in suicide cases were higher than concentrations measured in accidental deaths. The highest percentage of suicide decedents (36%) had a COHb level>70% saturation, accident decedents (36%) between 50% and 69% saturation, and homicide decedents (71%) below 50% saturation. Ethanol (N=34) was detected in 28% of deaths, and therapeutic and/or abused drugs (N=50) were detected in 41% of deaths. Illicit drugs were detected in 11% of cases (cocaine/metabolites; THC/metabolites), other drug positives were therapeutic medications. The most common drugs detected were antidepressants and antihistamines in suicides and pain medications and antihistamines in accidents.
authors.affiliation: Office of the Cuyahoga County Coroner, Cleveland, Ohio 44106, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Przepyszny
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Jenkins
mesh_terms: D000059:Accidents / Q000401:mortality; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D044383:Black People / Q000706:statistics & numerical data; D002249:Carbon Monoxide Poisoning / Q000401:mortality*; D002263:Carboxyhemoglobin / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D053593:Forensic Toxicology; D006708:Homicide / Q000706:statistics & numerical data; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis*; D007223:Infant; D008297:Male; D008875:Middle Aged; D009820:Ohio / Q000453:epidemiology; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012189:Retrospective Studies; D017678:Sex Distribution; D015813:Substance Abuse Detection / Q000706:statistics & numerical data; D019966:Substance-Related Disorders / Q000453:epidemiology*; D013405:Suicide / Q000706:statistics & numerical data; D044465:White People / Q000706:statistics & numerical data; D001741:Black or African American
chemical_list: D013287:Illicit Drugs; D004364:Pharmaceutical Preparations; D002263:Carboxyhemoglobin