title: Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy.
abstract: We analysed the influence of mesial temporal lobe epilepsy on the thickness of the corpus callosum (CC) in a large sample of well-characterized patients (n = 96) and healthy controls (n = 28). In particular, we investigated whether callosal structures are differentially affected depending on the affected hemisphere and age of epilepsy onset. Overall, we observed that epilepsy is associated with a decreased thickness in posterior callosal regions. Patients with an early onset, especially patients with left onset, additionally exhibited a smaller callosal thickness in more anterior and midbody regions. These findings may reflect non-specific as well as specific effects of temporal lobe epilepsy on CC development and interhemispheric connectivity.
authors.affiliation: Department of Epileptology, University of Bonn, Germany. bernd.weber@ukb.uni-bonn.de
authors.forename: Bernd
authors.initials: B
authors.lastname: Weber
authors.forename: Eileen
authors.initials: E
authors.lastname: Luders
authors.forename: Jennifer
authors.initials: J
authors.lastname: Faber
authors.forename: Sabine
authors.initials: S
authors.lastname: Richter
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Quesada
authors.forename: Horst
authors.initials: H
authors.lastname: Urbach
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
authors.forename: Christian E
authors.initials: CE
authors.lastname: Elger
authors.forename: Christoph
authors.initials: C
authors.lastname: Helmstaedter
mesh_terms: D000328:Adult; D017668:Age of Onset; D001284:Atrophy / Q000473:pathology; D001931:Brain Mapping / Q000379:methods; D003337:Corpus Callosum / Q000473:pathology*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged