Cytokine pattern in Kaposi's sarcoma associated with immune restoration disease in HIV and tuberculosis co-infected patients.
We analysed the evolution of different cytokines (IL-4, IL-6, tumour necrosis factor alpha and vascular endothelial growth factor; VEGF) involved in the development of Kaposi's sarcoma in two patients in whom HIV infection presented with disseminated Mycobacterium tuberculosis infection. They simultaneously developed tuberculosis-associated immune restoration disease and Kaposi's sarcoma shortly after the initiation of HAART. Analysis of VEGF and pro-inflammatory cytokines led us to hypothesize that Kaposi's sarcoma could be promoted by the tuberculosis immune response.
Tamburini
Jérôme
J
Department of Infectious Diseases, Pitié-Salpêtrière Hospital, Paris, France.
Grimaldi
David
D
Chiche
Jean-Daniel
JD
Bricaire
François
F
Bossi
Philippe
P
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D016207:Cytokines / Q000097:blood*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000097:blood / Q000150:complications / Q000276:immunology; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000276:immunology*; D006801:Humans; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D012142:Respiratory Tract Neoplasms / Q000097:blood / Q000150:complications / Q000276:immunology; D012514:Sarcoma, Kaposi / Q000097:blood / Q000150:complications / Q000276:immunology*; D012878:Skin Neoplasms / Q000097:blood / Q000150:complications / Q000276:immunology; D014376:Tuberculosis / Q000097:blood / Q000150:complications / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
D016207:Cytokines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; D015847:Interleukin-4