title: Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes.
abstract: Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes.
authors.affiliation: Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095, USA.
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mesh_terms: D000818:Animals; D002999:Clone Cells; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D005123:Eye / Q000254:growth & development; D020043:Genes, Essential; D017344:Genes, Insect; D005804:Genes, Lethal / Q000235:genetics*; D049750:Genome, Insect; D009154:Mutation; D014960:X Chromosome