Is the brain biopsy obligatory or not for the diagnosis of Schilder's disease? Review of the literature.
BACKGROUND
Schilder's myelinoclastic diffuse sclerosis (Schilder's disease) is a rare demyelinating disorder. Clinical features and neuroimaging findings of this disease might mimic an intra-cranial mass lesion including an abscess or a tumour.


METHODS
Clinical and radiological findings of two children with the diagnosis of Shilder's disease are reported, and the role of brain biopsy as a diagnostic tool is discussed.
Yilmaz
Yuksel
Y
Department of Pediatrics, Division of Pediatric Neurology, Marmara University, School of Medicine, Istanbul, Turkey. yukselymd@e-kolay.net
Kocaman
Canan
C
Karabagli
Hakan
H
Ozek
Memet
M
D001706:Biopsy / Q000379:methods / Q000592:standards; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D002648:Child; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D013256:Steroids / Q000008:administration & dosage / Q000627:therapeutic use
D013256:Steroids