[Tiagabine overdose--report of two cases].
Tiagabine is a derivative of nipecotinic acid used in the therapy of partial seizures, partial seizures with secondary generalization, stress disorder, psychosis and cocaine dependence. The pharmacologic effect of the drug is achieved by inhibition of reuptake of gamma aminobutyric acid (GABA) into glial cells and neurons, without permanent increase in whole brain GABA concentration. Symptoms of acute tiagabine overdose include seizures, coma, respiratory depression ' and less often dystonias, involuntary movements, somnolence, agitation, tachycardia and increase or decrease of blood pressure. Two cases of acute tiagabine overdose have been described in the paper presenting with partial and generalized seizures which were managed with benzodiazepines.


CONCLUSIONS
The onset of symptoms of acute tiagabine overdose is rapid with resolution within first 24 hours from exposure. Acute tiagabine poisoning may present with a wide variety of neurological symptoms. Administration of benzodiazepines may improve the outcome of overdose.
Wiśniewski
Marek
M
Katedra i Klinika Chorób Wewnetrznych, Geriatrii i Toksykologii Klinicznej, Akademii Medycznej w Gdańsku. m.wisniewski@amg.gda.pl
Sein Anand
Jacek
J
Chodorowski
Zygmunt
Z
Kosińska-Tomczyk
Henryka
H
D000328:Adult; D000927:Anticonvulsants / Q000506:poisoning*; D001569:Benzodiazepines / Q000627:therapeutic use; D062787:Drug Overdose; D004828:Epilepsies, Partial / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D014179:Neurotransmitter Uptake Inhibitors / Q000506:poisoning*; D009557:Nipecotic Acids / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy*; D012640:Seizures / Q000139:chemically induced; D013406:Suicide, Attempted; D000078308:Tiagabine; D016896:Treatment Outcome
D000927:Anticonvulsants; D014179:Neurotransmitter Uptake Inhibitors; D009557:Nipecotic Acids; D001569:Benzodiazepines; D000078308:Tiagabine