title: Three fatal cases of rapidly progressive infective endocarditis caused by Staphylococcus aureus: one case with huge vegetation.
abstract: Staphylococcus aureus (S. aureus) infective endocarditis (IE) is a severe disease with a high mortality despite intensive therapy. Three cases of S. aureus IE had a rapidly progressive fatal clinical course despite intensive antimicrobial therapy. One case was methicillin-sensitive S. aureus IE, which formed rapidly growing a huge vegetation on a prosthetic mitral valve, complicated with multiple systemic emboli. The other 2 cases were methicillin-resistant S. aureus IE without any predisposing heart disease.
authors.affiliation: Department of Cardiology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Miyata
authors.forename: Shinji
authors.initials: S
authors.lastname: Satoh
authors.forename: Kosuke
authors.initials: K
authors.lastname: Inokuchi
authors.forename: Akemi
authors.initials: A
authors.lastname: Aso
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Kimura
authors.forename: Shinji
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Etsuo
authors.initials: E
authors.lastname: Mori
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nakamura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Fujino
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kishihara
authors.forename: Ken
authors.initials: K
authors.lastname: Uda
authors.forename: Koichiro
authors.initials: K
authors.lastname: Takemoto
authors.forename: Toru
authors.initials: T
authors.lastname: Inoue
authors.forename: Suguru
authors.initials: S
authors.lastname: Nakayama
authors.forename: Ryozo
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Noriko
authors.initials: N
authors.lastname: Uesugi
authors.forename: Koji
authors.initials: K
authors.lastname: Hiyamuta
mesh_terms: D000368:Aged; D024881:Drug Resistance, Bacterial; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006801:Humans; D008297:Male; D008712:Methicillin; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology; D013203:Staphylococcal Infections / Q000473:pathology*; D013211:Staphylococcus aureus
chemical_list: D008712:Methicillin