[Diethylstilbestrol exposure in utero. Polemics about metroplasty. The cons].
Uterine malformations in DES-exposed women are not the only aetiologies for infertility, miscarriages, and other problems in their reproductive life. A global screening of fertility factors of the couple may, for instance, show in them vascular uterine abnormalities which reduce their reproductive potential. Furthermore, these abnormalities are not always predictive of losses of pregnancy, and many exposed women with patent uterine abnormalities can carry a pregnancy to term. Metroplasty for uterine enlargement is a surgical procedure suggested for restoring the size and shape of the uterine cavity. There are no comparative studies for assessing efficacy and safety of metroplasty. Therefore, metroplasty should not be performed routinely, but should only be considered after the couple has undergone a full fertility workup, and the best possible level of fertility has been achieved.
Epelboin
S
S
Service de gynécologie-obstétrique, unité de médecine de la reproduction, hôpital Saint-Vincent-de-Paul, GHU Cochin-Saint-Vincent-de-Paul, 82, avenue Denfert-Rochereau, 75014 Paris, France. s.epelboin@svp.aphp.fr
D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced; D006801:Humans; D015907:Hysteroscopy; D007247:Infertility, Female / Q000139:chemically induced; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D014599:Uterus / Q000187:drug effects / Q000473:pathology* / Q000601:surgery*
D004054:Diethylstilbestrol