A single-point mutation converts the highly amyloidogenic human islet amyloid polypeptide into a potent fibrillization inhibitor.
Abedini
Andisheh
A
Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794-3400, USA.
Meng
Fanling
F
Raleigh
Daniel P
DP
D000595:Amino Acid Sequence; D000682:Amyloid / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000235:genetics*; D002942:Circular Dichroism; D006801:Humans; D058228:Islet Amyloid Polypeptide; D046529:Microscopy, Electron, Transmission; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology*; D017354:Point Mutation
D000682:Amyloid; D058228:Islet Amyloid Polypeptide; D010446:Peptide Fragments