title: The number of loci that affect milk production traits in dairy cattle.
abstract: We have used the results of an experiment mapping quantitative trait loci (QTL) affecting milk yield and composition to estimate the total number of QTL affecting these traits. We did this by estimating the number of segregating QTL within a half-sib daughter design using logic similar to that used to estimate the "false discovery rate" (FDR). In a half-sib daughter design with six sire families we estimate that the average sire was heterozygous for approximately 5 QTL per trait. Also, in most cases only one sire was heterozygous for any one QTL; therefore at least 30 QTL were likely to be segregating for these milk production traits in this Holstein population.
authors.affiliation: Animal Genetics and Genomics Platform, Department of Primary Industries Victoria, Attwood, 3049, Victoria, Australia. amanda.chamberlain@dpi.vic.gov.au
authors.forename: Amanda Jane
authors.initials: AJ
authors.lastname: Chamberlain
authors.forename: Helen Clare
authors.initials: HC
authors.lastname: McPartlan
authors.forename: Michael Edward
authors.initials: ME
authors.lastname: Goddard
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D007774:Lactation / Q000235:genetics*; D008892:Milk; D010375:Pedigree; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable