title: A polymorphism in the resistin gene promoter and the risk of coronary artery disease in a Chinese population.
abstract: OBJECTIVE
  Resistin, a novel adipocyte-derived peptide, has been linked to the pathogenesis of atherosclerosis. Recently, -420C>G, a variant located in the promoter region of the resistin gene (RETN) was identified. The aim of this study was to investigate the association between this RETN-420C>G polymorphism and the risk of coronary artery disease (CAD).
  
  
  METHODS
  A hospital-based case-control study.
  
  
  METHODS
  A total of 225 CAD patients and 225 age- and sex-matched control subjects.
  
  
  METHODS
  Genotyping was performed by polymerase chain reaction (PCR) and restriction enzyme analysis to detect the presence of the RETN-420C>G polymorphism.
  
  
  RESULTS
  The frequencies of RETN-420C>G genotypes in the CAD group were significantly different from those in the control group (P = 0.024). Subjects with the variant genotypes (CG and GG) had a 62% increased risk of CAD compared to CC carriers [adjusted odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.09-2.41, P = 0.016]. However, there were no significant differences between the genotypes with respect to weight, body mass index (BMI) and lipid profiles in CAD patients, and no significant association was found between the RETN-420C>G polymorphism and the severity of CAD.
  
  
  CONCLUSIONS
  Our data suggest that the RETN-420C>G polymorphism might be associated with an increased risk of CAD in a Chinese population.
authors.affiliation: Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, China.
authors.forename: Na-Ping
authors.initials: NP
authors.lastname: Tang
authors.forename: Lian-Sheng
authors.initials: LS
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.forename: Hai-Juan
authors.initials: HJ
authors.lastname: Gu
authors.forename: Qing-Min
authors.initials: QM
authors.lastname: Sun
authors.forename: Ri-Hong
authors.initials: RH
authors.lastname: Cong
authors.forename: Huai-Jun
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D052243:Resistin / Q000235:genetics*
chemical_list: D052243:Resistin