Inflammation, endothelial dysfunction and angiogenesis markers in chronic heart failure patients.
This study was conducted to assess the relationship among circulating markers of inflammation, endothelial dysfunction and angiogenesis in 59 chronic heart failure (CHF) patients. Increased concentrations of C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha), von Willebrand factor (VWF) and fibrinogen are strongly implicated in the development of CHF. Increased vascular endothelium grow factor (VEGF) and decreased thrombospondin-1 (TSP-1) concentrations suggest a role of angiogenesis in the maintenance and repair of luminal endothelium in CHF. A relationship among markers of endothelial dysfunction (VWF) and inflammation (fibrinogen, CRP) and angiogenesis (VEGF, TSP-1) was found in CHF patients.
Vila
Virtudes
V
Martínez-Sales
Vicenta
V
Almenar
Luis
L
Lázaro
Ignacio Sánchez
IS
Villa
Piedad
P
Reganon
Edelmiro
E
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology*; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000097:blood*
D015415:Biomarkers; D018836:Inflammation Mediators