A novel fluorine-metal exchange reaction of pentafluorocrotonate with organocuprate. Generation of beta-metallated tetrafluorocrotonate and its cross-coupling reaction.
Fluorine-metal exchange reaction of 2,3,4,4,4-pentafluorocrotonates with organocuprate derived from Grignard reagent and CuCN takes place efficiently to generate the beta-metallated tetrafluorocrotonate intermediate, which reacts with various electrophiles to give beta-substituted 2,4,4,4-tetrafluorocrotonates.
Yamada
Shigeyuki
S
Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-8585, Japan.
Takahashi
Toshio
T
Konno
Tsutomu
T
Ishihara
Takashi
T