title: The influence of sperm morphology on preimplantation genetic diagnosis cycles outcome.
abstract: OBJECTIVE
  To evaluate the impact of abnormal sperm morphology on the rates of aneuploidy, implantation, and clinical pregnancy.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University-based IVF center.
  
  
  METHODS
  Fifty-two patients undergoing their first IVF-preimplantation genetic diagnosis (PGD) cycle.
  
  
  METHODS
  The PGD analysis of embryos.
  
  
  METHODS
  Patients were divided into two groups based on sperm morphology: teratospermic group (TSG) and normal sperm group (NSG). The primary outcome measures of rates of aneuploidy, implantation, clinical pregnancy rate (PR) per cycle, and clinical PR per embryo transfer were compared between TSG and NSG according to PGD analysis results.
  
  
  RESULTS
  A higher percentage of normal embryos was seen in the NSG (32%) versus the TSG (20%). Overall, 30% of IVF-PGD cycles had no normal embryos for transfer. The clinical PR per cycle was 44% in the NSG compared to 14% in the TSG (relative risk [RR] = 3.19; 95% confidence interval [CI] 1.1-9.0). A similar trend was noted with the clinical PR per embryo transfer with 57% patients becoming pregnant in the NSG versus 20% patients in the TSG (RR = 2.76; 95% CI 1.2-7.2). Implantation was twice as likely to occur in the NSG as compared to TSG (RR = 2.5; 95% CI 1.1-7.2).
  
  
  CONCLUSIONS
  Rates of euploidy, implantation, clinical PR per cycle, and clinical PR per embryo transfer were higher in the NSG compared to the TSG, suggesting that sperm morphology plays an important role in the outcome of IVF-PGD cycles.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The George Washington University, Washington, D.C. 20037, USA. adubey@mfa.gwu.edu
authors.forename: Anil
authors.initials: A
authors.lastname: Dubey
authors.forename: Molina B
authors.initials: MB
authors.lastname: Dayal
authors.forename: David
authors.initials: D
authors.lastname: Frankfurter
authors.forename: Pauline
authors.initials: P
authors.lastname: Balazy
authors.forename: Douglas
authors.initials: D
authors.lastname: Peak
authors.forename: Paul R
authors.initials: PR
authors.lastname: Gindoff
mesh_terms: D000328:Adult; D000782:Aneuploidy; D001755:Blastocyst / Q000473:pathology / Q000502:physiology; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000706:statistics & numerical data; D004622:Embryo, Mammalian / Q000166:cytology / Q000502:physiology; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D008297:Male; D054315:Oocyte Retrieval; D009865:Oocytes / Q000166:cytology; D011247:Pregnancy; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis / Q000379:methods* / Q000706:statistics & numerical data; D013094:Spermatozoa / Q000002:abnormalities / Q000166:cytology* / Q000502:physiology