Cardiac memory induced by QRS widening due to propafenone toxicity.
Propafenone toxicity can cause significant QRS widening and markedly abnormal ventricular activation pattern. Aberrant ventricular activation upon its resolution is known to produce persistent T-wave changes known as "cardiac memory" (CM). A 74-year-old woman presented with a severely abnormal electrocardiogram consistent with propafenone toxicity. As her QRS complex narrowed, T-wave inversions developed with the T-wave axis and resolution kinetics consistent with CM. Abnormal ventricular activation due to propafenone toxicity can result in CM development.
Wylie
John V
JV
Harvard-Thorndike Electrophysiology Institute,Harvard Medical School, Boston, Massachusetts, USA.
Zimetbaum
Peter
P
Josephson
Mark E
ME
Shvilkin
Alexei
A
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D006801:Humans; D011405:Propafenone / Q000009:adverse effects*; D014693:Ventricular Fibrillation / Q000139:chemically induced* / Q000175:diagnosis* / Q000517:prevention & control
D000889:Anti-Arrhythmia Agents; D011405:Propafenone