title: Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome.
abstract: The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, University of Uludag, Bursa, Turkey. ahmetursavas@gmail.com.|Uludağ Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları ve Tüberküloz AD, 16059, Görükle, Bursa, Turkey. ahmetursavas@gmail.com.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ursavas
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, University of Uludag, Bursa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karadag
authors.affiliation: Department of Biochemistry, School of Medicine, University Of Uludag, Bursa, Turkey.
authors.forename: Yesim Ozarda
authors.initials: YO
authors.lastname: Ilcol
authors.affiliation: Department of Biostatistics, School of Medicine, University Of Uludag, Bursa, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Ercan
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, University of Uludag, Bursa, Turkey.
authors.forename: Basak
authors.initials: B
authors.lastname: Burgazlioglu
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, University of Uludag, Bursa, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Coskun
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, University of Uludag, Bursa, Turkey.
authors.forename: R Oktay
authors.initials: RO
authors.lastname: Gozu
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D016022:Case-Control Studies; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D017286:Polysomnography; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications
chemical_list: D007334:Insulin-Like Growth Factor I