A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55.
A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A(1) and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of beta-arrestin in HeLa cells at the concentration of 20 microM.
Ueda
Jun-Ya
JY
Japan Biological Information Research Center (JBIRC), Japan Biological Informatics Consortium (JBIC), Tokyo, Japan. hasumi@cc.tuat.ac.jp
Togashi
Takushi
T
Matukura
Susumu
S
Nagai
Aya
A
Nakashima
Takuji
T
Komaki
Hisayuki
H
Anzai
Kozue
K
Harayama
Shigeaki
S
Doi
Takayuki
T
Takahashi
Takashi
T
Natsume
Tohru
T
Kisu
Yasutomo
Y
Goshima
Naoki
N
Nomura
Nobuo
N
Takagi
Motoki
M
Shin-Ya
Kazuo
K
D021581:Active Transport, Cell Nucleus / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D011728:Pyridones / Q000494:pharmacology*; D013057:Spectrum Analysis; D013302:Streptomyces
D000900:Anti-Bacterial Agents; C524347:JBIR-02 compound; D011725:Pyridines; D011728:Pyridones; C100213:piericidin A