title: Hemodynamic and metabolic changes during exercise in calves with total artificial hearts of different sizes yet similar output.
abstract: To evaluate the effects of downsizing of the total artificial heart (TAH), we compared the anaerobic threshold (AT) values in calves with two different types of TAH (Cleveland Clinic-Nimbus TAH and the downsized MagScrew TAH). Exercise studies were performed using a treadmill in 12 calves. During the exercise, parameters to obtain the AT were measured. To evaluate the determinants of the AT, a linear regression analysis was performed between AT and potential variables. AT values from 29 studies revealed no significant differences between the two different TAHs, with no significant differences in hemodynamic or oxygen metabolic parameters. AT values correlated well with pump flow/body weight (Q) multiplied by the hemoglobin level, regardless of the TAH used. In conclusion, downsizing of the original TAH design did not reduce AT without any significant differences in hemodynamic or oxygen metabolic parameters during exercise in calves.
authors.affiliation: Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Keiji
authors.initials: K
authors.lastname: Kamohara
authors.forename: Stephan
authors.initials: S
authors.lastname: Weber
authors.forename: Ryan S
authors.initials: RS
authors.lastname: Klatte
authors.forename: Viviane
authors.initials: V
authors.lastname: Luangphakdy
authors.forename: Christine R
authors.initials: CR
authors.lastname: Flick
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ootaki
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Akiyama
authors.forename: Faruk
authors.initials: F
authors.lastname: Cingoz
authors.forename: Chiyo
authors.initials: C
authors.lastname: Ootaki
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kopcak
authors.forename: Jenny
authors.initials: J
authors.lastname: Liu
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Chen
authors.forename: Jose L
authors.initials: JL
authors.lastname: Navia
authors.forename: William A
authors.initials: WA
authors.lastname: Smith
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
mesh_terms: D015308:Anaerobic Threshold; D000818:Animals; D001775:Blood Circulation; D002417:Cattle; D004867:Equipment Design; D006354:Heart, Artificial; D006454:Hemoglobins / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood*; D016014:Linear Models; D008422:Materials Testing; D008955:Models, Cardiovascular; D010101:Oxygen Consumption; D005082:Physical Exertion; D012107:Research Design
chemical_list: D006454:Hemoglobins; D019344:Lactic Acid