Beta2-chimaerin in cancer signaling: connecting cell adhesion and MAP kinase activation.
The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates beta2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in human cancer cell lines that together lend new mechanistic insight into the role of chimaerins in cancer.
Bruinsma
Stephen P
SP
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Baranski
Thomas J
TJ
D000818:Animals; D002448:Cell Adhesion; D018450:Disease Progression; D004789:Enzyme Activation; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction
D009363:Neoplasm Proteins; C079844:beta-chimaerin; D020928:Mitogen-Activated Protein Kinases