title: Hematologic and urinary excretion anomalies in patients with chronic fatigue syndrome.
abstract: Patients with chronic fatigue syndrome (CFS) have a broad and variable spectrum of signs and symptoms with variable onsets. This report outlines the results of a single-blind, cross-sectional research project that extensively investigated a large cohort of 100 CFS patients and 82 non fatigued control subjects with the aim of performing a case-control evaluation of alterations in standard blood parameters and urinary amino and organic acid excretion profiles. Blood biochemistry and full blood counts were unremarkable and fell within normal laboratory ranges. However, the case-control comparison of the blood cell data revealed that CFS patients had a significant decrease in red cell distribution width and increases in mean platelet volume, neutrophil counts, and the neutrophil-lymphocyte ratio. Evaluation of the urine excretion parameters also revealed a number of anomalies. The overnight urine output and rate of amino acid excretion were both reduced in the CFS group (P < 0.01). Significant decreases in the urinary excretion of asparagine (P < 0.0001), phenylalanine (P < 0.003), the branch chain amino acids (P < 0.005), and succinic acid (P < 0.0001), as well as increases in 3-methylhistidine (P < 0.05) and tyrosine (P < 0.05) were observed. It was concluded that the urinary excretion and blood parameters data supported the hypothesis that alterations in physiologic homeostasis exist in CFS patients.
authors.affiliation: Environmental and Pathogenic Microbiology Laboratory, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
authors.forename: Suzanne H
authors.initials: SH
authors.lastname: Niblett
authors.forename: Katrina E
authors.initials: KE
authors.lastname: King
authors.forename: R Hugh
authors.initials: RH
authors.lastname: Dunstan
authors.forename: Phillip
authors.initials: P
authors.lastname: Clifton-Bligh
authors.forename: Leigh A
authors.initials: LA
authors.lastname: Hoskin
authors.forename: Timothy K
authors.initials: TK
authors.lastname: Roberts
authors.forename: Greg R
authors.initials: GR
authors.lastname: Fulcher
authors.forename: Neil R
authors.initials: NR
authors.lastname: McGregor
authors.forename: Julie C
authors.initials: JC
authors.lastname: Dunsmore
authors.forename: Henry L
authors.initials: HL
authors.lastname: Butt
authors.forename: Iven
authors.initials: I
authors.lastname: Klineberg
authors.forename: T B
authors.initials: TB
authors.lastname: Rothkirch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood* / Q000652:urine*; D001774:Blood Chemical Analysis; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D048429:Cell Size; D003430:Cross-Sectional Studies; D004912:Erythrocytes / Q000378:metabolism / Q000473:pathology; D015673:Fatigue Syndrome, Chronic / Q000097:blood* / Q000473:pathology / Q000652:urine*; D005260:Female; D006706:Homeostasis; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged
chemical_list: D000596:Amino Acids