title: HDL-inflammatory index correlates with poor outcome in hemodialysis patients.
abstract: Oxidative stress and cardiovascular disease are risk factor of patients with chronic kidney disease (CKD) on maintenance hemodialysis. We used the fluorescence of low-density lipoprotein as an index of its proinflammatory potential to examine any role that high-density lipoprotein (HDL) might have in promoting this effect. The total body fat of the patients was measured by means of near-infrared interactance and their quality of life by means of SF36 questionnaires. In 189 randomly selected patients, followed for 30 months, HDL was found to be significantly anti-inflammatory but with a large standard deviation. Fully 17% of the patients had a decidedly proinflammatory index along with inferior SF36 scores. The patients were divided into 10% increments of total body fat percentages up to 40%. HDL was found to be progressively proinflammatory the higher the body fat content. Patients with a higher HDL proinflammatory index had a higher 30-month adjusted hazard ratio for death than those whose HDL were seen to be anti-inflammatory. Our findings suggest an important role of inflammatory HDL in patients with CKD leading to poor outcome.
authors.affiliation: Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA. kamkal@ucla.edu
authors.forename: K
authors.initials: K
authors.lastname: Kalantar-Zadeh
authors.forename: J D
authors.initials: JD
authors.lastname: Kopple
authors.forename: N
authors.initials: N
authors.lastname: Kamranpour
authors.forename: A M
authors.initials: AM
authors.lastname: Fogelman
authors.forename: M
authors.initials: M
authors.lastname: Navab
mesh_terms: D015415:Biomarkers / Q000097:blood; D001823:Body Composition / Q000502:physiology; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D007249:Inflammation; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000097:blood* / Q000175:diagnosis / Q000628:therapy*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D011379:Prognosis; D011788:Quality of Life; D006435:Renal Dialysis; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D008075:Lipoproteins, HDL