[Study on lipid-regulating function for the extracts and their prescriptions from Semen Cassiae and fructus crataegi].
OBJECTIVE
To study the effect of lipid-regulating function for extracts and their prescriptions from Semen Cassiae and Crataegus pinnatifida Bge. var. major N. E. Br. on serum lipid of hyperlipidema mice.


METHODS
1 week after being administered with extract of Semen Cassiae, extract of Crataegus pinatifida Bge. var. major N. E. Br. and different proportion mixture of them (180 mg/ kg), mice were treated with ip 75% fresh yelkfluid. The contents of TC, TG, HDL-C, LDL-C, apo AI and apo B were observed after 24 h.


RESULTS
The levels of TC, TG, LDL-C and apoB in therapeutic group were lower than those in hyperlipidemic model group (P < 0.05, P < 0.01), especially in different proportion mixture groups.


CONCLUSIONS
Lipid-regulating active part of Semen Cassiae and Crataegus pinatifida Bge. var. major N. E. Br. might inhibit hyperlipidemic formation, and mixture groups were more effective than those of its single extract.
Li
Hai-Bin
HB
Guangzhou City Polytechnic College, Guangzhou 510405, China.
Fang
Kun-Yang
KY
Lü
Cui-Ting
CT
Li
Xu-E
XE
D000818:Animals; D002366:Cassia / Q000737:chemistry; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D027825:Crataegus / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005638:Fruit / Q000737:chemistry; D006949:Hyperlipidemias / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008055:Lipids / Q000097:blood*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D004365:Drugs, Chinese Herbal; D000960:Hypolipidemic Agents; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol