Paraneoplastic pemphigus presenting as erythrodermic lichenoid dermatitis with concomitant features of pemphigus foliaceus.
We describe a patient with paraneoplastic pemphigus who presented with erythrodermic lichenoid dermatitis, later developing blisters of pemphigus foliaceus type and oral erosive lesions. In addition to antibodies against the plakin family proteins, the patient's serum was positive for anti-desmoglein 1 antibodies without coexisting anti-desmoglein 3 activities by enzyme-linked immunosorbent assay, which is a very rare autoantibody profile in paraneoplastic pemphigus.
Fukumoto
Takaya
T
Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan. tfukumot@naramed-u.ac.jp
Shiroyama
Yoshimi
Y
Niizeki
Hironori
H
Kobayashi
Nobuhiko
N
Asada
Hideo
H
Ishii
Norito
N
Hashimoto
Takashi
T
Miyagawa
Sachiko
S
D001323:Autoantibodies / Q000097:blood*; D003873:Dermatitis, Exfoliative / Q000209:etiology; D051183:Desmoglein 1 / Q000276:immunology; D051184:Desmoglein 3 / Q000276:immunology; D005260:Female; D005802:Genes, MHC Class II; D006801:Humans; D007159:Immunologic Tests; D017512:Lichenoid Eruptions / Q000209:etiology; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D010392:Pemphigus / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000473:pathology*
D001323:Autoantibodies; D051183:Desmoglein 1; D051184:Desmoglein 3