[Study of the polymorphic markers--the PARK2 and PACRG genes due to the incidence of pulmonary tuberculosis in two districts of the Republic of Tyva].
Polymerase chain reaction-RFLP was used to distribute two polymorphic markers (SNP) PARK2-e01 (-697) and rs1333955 located at the common promoter site of the PARK2 and PACRG genes in order to reveal assumed associations with the incidence of pulmonary tuberculosis in the Barum-Khemchiksky and Ovyursky Districts of the Republic of Tyva. No significant differences were found in the frequencies of these two polymorphic markers between the groups of patients with tuberculosis and healthy individuals, residing in the above districts, and between the total control samples from both districts. The total group of patients with tuberculosis from the two districts from the Republic of Tyva showed a significant surplus of heterozygotes in both study markers, as compared with the group of healthy individuals, which was also observed for the marker rs1333955 in the Barum-Khemchksky District alone. The observed features of genotypic distribution by the two study markers point to the influence of the considered markers on the incidence of tuberculosis.
Udina
I G
IG
Kordicheva
S Iu
SIu
Pospelov
L E
LE
Malenko
A F
AF
Gergert
V Ia
VIa
Pospelov
A L
AL
Matrashkin
A G
AG
Kyzyl-Ool
M M
MM
Nachin
A A
AA
Zhivotovskiĭ
L A
LA
D015415:Biomarkers / Q000378:metabolism; D004247:DNA / Q000235:genetics*; D004586:Electrophoresis; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008840:Microfilament Proteins; D018832:Molecular Chaperones / Q000235:genetics* / Q000378:metabolism; D010300:Parkinson Disease; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012426:Russia / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000235:genetics* / Q000378:metabolism
D015415:Biomarkers; D008840:Microfilament Proteins; D018832:Molecular Chaperones; C471711:PACRG protein, human; D004247:DNA; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein