[NO-dependent mechanisms of ecdysterone protective action on the heart and vessels in streptozotocin-induced diabetes mellitus in rats].
Ecdysterone (100 ng/100 g) chronic oral administration (2 months after STZ (5 mg/100 g) administration) normalized plasma glucose levels in rats. This potent hypoglycemic effect of ecdysterone depend on inhibition of non-constitutive NO synthesis by Ca(2+)-independent iNOS and NADP-dependent nitrate reductase as well as inhibition of L-arginine degradation by arginase result in up-regulation of Ca(2+)-dependent constitutive NO synthesis by eNOS or mithochondrial nNOS in heart and aorta of rats.
Korkach
Iu P
IuP
Kotsiuruba
A V
AV
Prysiazhna
O D
OD
Mohyl'nyts'ka
L D
LD
Sahach
V F
VF
D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D004441:Ecdysterone / Q000494:pharmacology / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis / Q000502:physiology*; D051381:Rats; D011921:Rats, Inbred WKY; D013311:Streptozocin; D014664:Vasodilation / Q000187:drug effects
D001786:Blood Glucose; D002316:Cardiotonic Agents; D009569:Nitric Oxide; D004441:Ecdysterone; D013311:Streptozocin