title: A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus.
abstract: An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.
authors.affiliation: Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.
authors.forename: Eleusa Maria F
authors.initials: EM
authors.lastname: Rocha
authors.forename: Guillermo
authors.initials: G
authors.lastname: Garcia-Effron
authors.forename: Steven
authors.initials: S
authors.lastname: Park
authors.forename: David S
authors.initials: DS
authors.lastname: Perlin
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000235:genetics; D025141:Drug Resistance, Fungal / Q000235:genetics*; D054714:Echinocandins / Q000494:pharmacology*; D005656:Fungal Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors / Q000235:genetics*; D008969:Molecular Sequence Data; D011392:Proline / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D012694:Serine / Q000235:genetics
chemical_list: D054714:Echinocandins; D005656:Fungal Proteins; D012694:Serine; D011392:Proline; D005964:Glucosyltransferases; C040232:glucan synthase