Effects of sex hormones on rat tongue carcinoma induced by 4-nitroquinoline 1-oxide (4NQO).
We investigated the regulatory effects of sex hormones on tongue carcinoma initiated by orally administration 4-nitroquinoline 1-oxide (4NQO) to rats. Animals of either sex were classified into three groups. The male rats in each group received an estrogen administration (Me), orchiectomy (Mor), or both treatments (Me/or) while the female rats also received testosterone administration (Ft), ovariectomy (Fov), or both treatments (Ft/ov). The differences in the carcinogenic progress among these groups were examined by macroscopic and microscopic observation of tongue tissues. The incidence of cancer in the tongue tissue was 100% in the group reinforced with testosterone (testosterone+group) (Ft, Ft/ov, Me) but only 56.0% in the group not reinforced with testosterone (testosterone-group) (Fov, Mor). These findings suggest that sex hormones play a role in the onset of 4NQO-induced tongue carcinoma.
Haque
Jhuma
J
Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Mihama-ku, Chiba, Japan.
Katakura
Akira
A
Katakuta
Akira
A
Kamiyama
Isao
I
Takagi
Ryo
R
Shibahara
Takahiko
T
Noma
Hiroyasu
H
D015112:4-Nitroquinoline-1-oxide; D000818:Animals; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004967:Estrogens / Q000009:adverse effects*; D005260:Female; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000009:adverse effects*; D014062:Tongue Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D004967:Estrogens; D013739:Testosterone; D015112:4-Nitroquinoline-1-oxide