MCP-1 and RANTES polymorphisms in Korean diabetic end-stage renal disease.
Macrophage infiltration has been observed in the renal biopsy specimens of diabetic nephropathy (DN), and hyperglycemic state stimulates the renal expression of RANTES (regulated upon activation, normal T-cell expressed and secreted) and MCP- 1 (monocyte chemoattractant protein-1). Upregulation of RANTES and MCP-1 with infiltrating macrophages may play a crucial role in the development and progression of DN. Genetic polymorphisms of RANTES and its receptors were reported to be independent risk factors for DN. We genotyped single nucleotide polymorphism (SNPs) in the MCP-1 G-2518A, CCR2 G46295A, RANTES C-28G and G-403A in 177 diabetic end-stage renal disease (ESRD) patients and 184 patients without renal involvement (controls) in order to investigate the effects of these SNPs on DN in Korean patients with type 2 DM. There were no differences in the frequencies of SNPs and the distribution of haplotypes of RANTES promoter SNPs between two groups. In conclusion, there were no associations of MCP-1, CCR2 and RANTES promoter SNPs with diabetic ESRD in Korean population. Prospective studies with clearly-defined, homogenous cohorts are needed to confirm the effect of these genetic polymorphisms on DN.
Joo
Kwon Wook
KW
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Hwang
Young Hwan
YH
Kim
Jae Hyeon
JH
Oh
Kook Hwan
KH
Kim
Hyunho
H
Shin
Hyoung Doo
HD
Chung
Woo Kyung
WK
Yang
Jaeseok
J
Park
Kyong Soo
KS
Ahn
Curie
C
D000368:Aged; D044466:Asian People / Q000235:genetics*; D018932:Chemokine CCL2 / Q000235:genetics*; D018946:Chemokine CCL5 / Q000235:genetics*; D016009:Chi-Square Distribution; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007676:Kidney Failure, Chronic / Q000208:ethnology / Q000209:etiology / Q000235:genetics*; D007723:Korea; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
D018932:Chemokine CCL2; D018946:Chemokine CCL5