title: Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications.
abstract: Polymorphonuclear neutrophils (PMN) are key components of the innate immunity and their efficient recruitment to the sites of lesion is a prerequisite for acute inflammation. Signaling via adhesion molecules of the beta2 integrin family (CD11/CD18) plays an essential role for PMN recruitment and activation during inflammation. In this review, we will focus on the non-receptor tyrosine kinase Syk, an important downstream signaling component of beta2 integrins that is required for the control of different PMN functions including adhesion, migration and phagocytosis. The exploration of beta2 integrin-mediated Syk activation provided not only novel insights into the control of PMN functions but also led to the identification of Syk as a new molecular target for therapeutic intervention during inflammatory diseases.
authors.affiliation: Department of Physiology, Ludwig-Maximilians-University Munich, Munich, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schymeinsky
authors.forename: Attila
authors.initials: A
authors.lastname: Mócsai
authors.forename: Barbara
authors.initials: B
authors.lastname: Walzog
mesh_terms: D018845:CD11 Antigens / Q000502:physiology*; D018821:CD18 Antigens / Q000502:physiology*; D006801:Humans; D007249:Inflammation; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D018375:Neutrophil Activation; D020556:Neutrophil Infiltration; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D000072377:Syk Kinase
chemical_list: D018845:CD11 Antigens; D018821:CD18 Antigens; D047908:Intracellular Signaling Peptides and Proteins; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase