title: Granulocyte colony-stimulating factor production and rapid progression of gastric cancer after histological change in the tumor.
abstract: Granulocyte colony-stimulating factor (G-CSF)-producing malignancies are thought to be rare and associated with advanced disease and poor prognosis. Here, we report on a 77-year-old patient with G-CSF-producing gastric cancer. We observed this patient from the stage prior to the diagnosis of gastric cancer when leukocyte count was normal to the stage of advanced disease associated with remarkable leukocytosis. Immunohistochemical analysis demonstrated G-CSF expression in the advanced-stage, poorly differentiated adenocarcinoma, but not in the early-stage, well-differentiated adenocarcinoma. G-CSF receptor was not detected to be expressed in the advanced-stage tumor. Based on these results it appears that a histological change in the tumor may influence G-CSF production and the concomitant rapid progression in gastric cancer.
authors.affiliation: Department of Surgery, Kawachi General Hospital, 1-31 Yokomakura, Higasi-Osaka, 578-0954, Japan. yamanot@kawati.org
authors.forename: Tomoki
authors.initials: T
authors.lastname: Yamano
authors.forename: Eiichi
authors.initials: E
authors.lastname: Morii
authors.forename: Jun-Ichiro
authors.initials: J
authors.lastname: Ikeda
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aozasa
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D000368:Aged; D001706:Biopsy; D002471:Cell Transformation, Neoplastic; D003111:Colonic Polyps / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology*; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery
chemical_list: D016179:Granulocyte Colony-Stimulating Factor