Brain metastases of melanoma--mechanisms of attack on their defence system by engineered stem cells in the microenvironment.
This report gives a better emphasis on the role of targeted effectors (e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone) and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers.
Dimitrov
Borislav D
BD
BORDANI, Alzano Lombardo, Bergamo 24022, Italy. bdd11@yahoo.com
Atanassova
Penka A
PA
Rachkova
Mariana I
MI
D001932:Brain Neoplasms / Q000276:immunology* / Q000601:surgery*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008545:Melanoma / Q000276:immunology / Q000556:secondary / Q000601:surgery; D018448:Models, Immunological; D033581:Stem Cell Transplantation / Q000379:methods*