title: Carcinosarcoma of the uterine cervix: case report and discussion.
abstract: Cervical carcinosarcomas are rare neoplasms; optimal treatment is unclear. CASE 1: A 42-year-old woman underwent abdominal hysterectomy because of bleeding, anaemia and uterine fibromatosis. Histology showed a homologous carcinosarcoma of the cervix. Laparoscopic re-staging (pelvic lymphadenectomy, bilateral salpingo-oophorectomy) was negative for neoplasia. Adjuvant chemotherapy with ifosfamide and cisplatin was performed. At 48 months of follow-up, the patient is NED. CASE 2: A 74-year-old woman reporting vaginal bleeding, with carcinosarcoma on the cervical biopsy, underwent radical hysterectomy, bilateral salpingo-oophorectomy, pelvic and paraortic lymphadenectomy. Histology confirmed a homologous carcinosarcoma of the cervix, stage IIb. Whole-pelvis irradiation and brachytherapy were carried out. Nine months later, the patient developed systemic recurrence and died of disease. Aggressive primary therapy can result in cure of early-stage cervical carcinosarcomas. Extracervical disease is associated with a poor prognosis.
authors.affiliation: Department of Obstetrics and Gynecology, University of Insubria, Varese, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Laterza
authors.forename: Anna
authors.initials: A
authors.lastname: Seveso
authors.forename: Francesca
authors.initials: F
authors.lastname: Zefiro
authors.forename: Giorgio
authors.initials: G
authors.lastname: Formenti
authors.forename: Luca
authors.initials: L
authors.lastname: Mellana
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Donadello
authors.forename: Fabio
authors.initials: F
authors.lastname: Ghezzi
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Bolis
authors.forename: Cristina
authors.initials: C
authors.lastname: Riva
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002296:Carcinosarcoma / Q000473:pathology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000628:therapy*
chemical_list: D002945:Cisplatin; D007069:Ifosfamide