title: [Antibody-mediated proteolysis of myelin-associated proteins as a new mechanism of control over demyelinization processes in multiple sclerosis].
abstract: Natural antibodies possessing catalytic activity present a new group of biologically active substances that are found in various autoimmune diseases such as autoimmune thyroiditis, myocarditis, multiple sclerosis, and system lupus erythematosus. Presently, an interconnection between the activity of these antibodies and the extent of organic and tissue lesion in autoaggression have been revealed. Clinical use of catalytic antibodies as a diagnostic criterion to evaluate the severity of disease, a prognostic criterion of the risk of invalidization, and as a pathogenetic basis for medicamentous treatment of autoimmune process is a promising directions of study of the role of catalytic antibodies.
authors.forename: S V
authors.initials: SV
authors.lastname: Suchkov
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Vvedenskaia
authors.forename: I L
authors.initials: IL
authors.lastname: Vostrikova
authors.forename: A G
authors.initials: AG
authors.lastname: Gabibov
authors.forename: M V
authors.initials: MV
authors.lastname: Kimova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Burdakova
authors.forename: N A
authors.initials: NA
authors.lastname: Ponomarenko
authors.forename: M A
authors.initials: MA
authors.lastname: Pal'tsev
mesh_terms: D017151:Antibodies, Catalytic; D018450:Disease Progression; D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D018992:Myelin-Associated Glycoprotein / Q000276:immunology* / Q000378:metabolism; D009413:Nerve Fibers, Myelinated / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D017151:Antibodies, Catalytic; D018992:Myelin-Associated Glycoprotein