Value of Toxoplasma gondii detection in one hundred thirty-three placentas for the diagnosis of congenital toxoplasmosis.
The placenta examination by polymerase chain reaction and mouse inoculation increased the sensitivity of the diagnosis of congenital toxoplasmosis at birth from 60% (use of serologic techniques on the newborn's blood only) to 75% (both serologic techniques and placental analysis). The specificity of Toxoplasma gondii detection in the placenta was 94.7%.
Fricker-Hidalgo
Hélène
H
Service de Parasitologie-Mycologie, Département des Agents Infectieux; Départements de Gynécologie Obstétrique, Centre Hospitalier Universitaire, BP217, 38043, Grenoble, France. hfricker-hidalgo@chu-grenoble.fr
Brenier-Pinchart
Marie-Pierre
MP
Schaal
Jean-Patrick
JP
Equy
Véronique
V
Bost-Bru
Cécile
C
Pelloux
Hervé
H
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D051379:Mice; D010920:Placenta / Q000469:parasitology*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011739:Pyrimethamine / Q000627:therapeutic use; D012680:Sensitivity and Specificity; D015572:Spiramycin / Q000627:therapeutic use; D013413:Sulfadoxine / Q000627:therapeutic use; D014122:Toxoplasma / Q000187:drug effects / Q000302:isolation & purification*; D014125:Toxoplasmosis, Congenital / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology*
D000890:Anti-Infective Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015572:Spiramycin; D013413:Sulfadoxine; D011739:Pyrimethamine