[Imbalance of oxidoreductive status in suicidal antidepressant drugs poisoning].
The aim of this study was to examine the association between suicidal poisoning with antidepressants and the oxidoreductive balance by evaluation of changes in activity of glutathione reductase (GR) and total antioxidative status (TAS) in serum. GR activity and TAS were determined in 29 patients hospitalized after suicidal poisoning with antidepressants and compared with the results of the control group consisting of 16 healthy people. For this purpose, RANDOX diagnostic sets were used. The GR activity and TAS were significantly lower in the examined group, compared with the control group. The results obtained show a significant reduction of GR activity and TAS level in patients with suicidal antidepressants poisoning. It seems, that the oxidoreductive balance is shift towards the oxidative potential and leads to the decrease of the organism's antioxidative potential, which is manifested by the increase of oxygen free radicals and the intensification of the oxidative stress.
Drelich
Grzegorz
G
Regionalny Ośrodek Toksykologii Klinicznej Samodzielny Publiczny Szpital Wojewódzki im. Jana Bozego w Lublinie. gdrelich@esculap.pl
Lewandowska-Stanek
Hanna
H
Jagiełło-Wójtowicz
Ewa
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000506:poisoning*; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012016:Reference Values; D013405:Suicide; D013406:Suicide, Attempted; D013482:Superoxide Dismutase / Q000097:blood*
D000928:Antidepressive Agents; D000975:Antioxidants; D015415:Biomarkers; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase