[The most important clinical interactions among medicines used in cardiologic practice].
This article presents a review of the most important (from the cardiologic practice point of view) interactions among medicines administered to the patients suffering from cardiovascular diseases, in particular among medicines with cytochrome P450 (and its isoenzymes) dependent metabolism. Cardiovascular patients, often advanced in age, usually affected by concomitant diseases and compelled to take many different medicines are particularly exposed to side effects dependent on these interactions. The article describes both beneficial and unprofitable interactions among medicines administered in cardiology.
Mikulski
Tomasz
T
Oddzial Internistyczno-Kardiologiczny i Regionalny Ośrodek Toksykologii Klinicznej Samodzielny Publiczny Szpital Wojewódzki im. Jana Bozego w Lublinie.
D000284:Administration, Oral; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000378:metabolism; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000378:metabolism; D001682:Biological Availability; D001711:Biotransformation; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism; D003580:Cytochromes / Q000187:drug effects* / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000378:metabolism; D008658:Inactivation, Metabolic
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D003580:Cytochromes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors