title: A novel fluorine-metal exchange reaction of pentafluorocrotonate with organocuprate. Generation of beta-metallated tetrafluorocrotonate and its cross-coupling reaction.
abstract: Fluorine-metal exchange reaction of 2,3,4,4,4-pentafluorocrotonates with organocuprate derived from Grignard reagent and CuCN takes place efficiently to generate the beta-metallated tetrafluorocrotonate intermediate, which reacts with various electrophiles to give beta-substituted 2,4,4,4-tetrafluorocrotonates.
authors.affiliation: Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-8585, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Yamada
authors.forename: Toshio
authors.initials: T
authors.lastname: Takahashi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Konno
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishihara