title: [Wegener's granulomatosis: manifestations of skin lesions].
abstract: 16 fatal cases of Wegener's granulomatosis (WG) were morphologically and histochemically studied. In all cases various changes were found, which generally correlated with the severity of the disease, depending on its course and complications and were responsible for the progression of the disease and deteriorated its prognosis. The morphological criterion of WG was destructive productive angiitis mainly of the microcirculatory bed, with the development of disseminated intravascular coagulation (DIC), and the formation of peri- and endovascularly specific, highly polymorphic granulation tissue, followed by its necrosis. DIC supplemented by infection resulted in impairment of trophism, hypo- and anoxia of tissue and, further all skin morphofunctional structures.
authors.forename: S A
authors.initials: SA
authors.lastname: Iampol'skaia
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology*