title: Molecular cloning and characterization of WD40-repeat protein from Clonorchis sinensis.
abstract: WD40-repeat proteins have four to eight repeating units flanked by Gly-His (GH) and Trp-Asp (WD) at both termini and folds into a beta-propeller. A polypeptide deduced from a Clonorchis sinensis cDNA clone analyzed to have seven WD40-repeats and predicted to form a beta-propeller (CsWD1). The CsWD1 protein was expressed stage-specifically in the metacercariae and localized in the tegumental syncytium. The CsWD1 protein is suggested to serve as a platform for interacting partner proteins in the tegumental syncytium of C. sinensis metacercariae.
authors.affiliation: Department of Parasitology, Chung-Ang University College of Medicine, Tongjak-gu, Seoul, 156-756, South Korea.
authors.forename: Pyo Yun
authors.initials: PY
authors.lastname: Cho
authors.forename: Tea Im
authors.initials: TI
authors.lastname: Kim
authors.forename: Won Gi
authors.initials: WG
authors.lastname: Yoo
authors.forename: Shunyu
authors.initials: S
authors.lastname: Li
authors.forename: Sung-Jong
authors.initials: SJ
authors.lastname: Hong
authors.forename: Tae Yun
authors.initials: TY
authors.lastname: Kim
authors.forename: Young Soon
authors.initials: YS
authors.lastname: Park
authors.forename: Kye-Yong
authors.initials: KY
authors.lastname: Song
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Choi
authors.forename: Sung-Tae
authors.initials: ST
authors.lastname: Hong
authors.forename: Yong Je
authors.initials: YJ
authors.lastname: Chung
authors.forename: Philip T
authors.initials: PT
authors.lastname: LoVerde
authors.forename: Ahmed
authors.initials: A
authors.lastname: Osman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D003004:Clonorchis sinensis / Q000378:metabolism*; D018076:DNA, Complementary / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology; D015801:Helminth Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data
chemical_list: D018076:DNA, Complementary; D015801:Helminth Proteins