[Nonsteroidal anti-inflammatory drugs. Declaration I. A study of interrelation "structure--the effectiveness of anti-inflammatory action"].
Using the computer system SARD-21 (Structure Activity Relationship & Design) the structural features typical for high- and low- effective nonsteroid anti-inflammatory drugs (NSAIDs) were analyzed. This information has been used for the model for prediction of anti-inflammatory effectiveness of medicines with 76% and 81% level of recognition by two methods. New data can be used for creating new highly effective NSAIDs, and for increasing effectiveness of already known components.
Khaĭrullina
V R
VR
Mukhametov
A D
AD
Tiurina
L A
LA
Garifullina
G G
GG
Gerchikov
A Ia
AIa
Zarudiĭ
F S
FS
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D003198:Computer Simulation; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry*; D015195:Drug Design; D015394:Molecular Structure; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry*; D012984:Software; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011451:Prostaglandin-Endoperoxide Synthases