Insulin resistance in adolescents.
OBJECTIVE
To investigate the relationship of other body mass index (BMI) ranges with Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), a surrogate marker for insulin resistance in adolescents.


METHODS
Cross-sectional analysis of a nationally representative sample of 1837 nondiabetic, nonpregnant 12 to 19 year old persons from the National Health and Nutrition Examination Survey, 1999-2002. The main outcome measurement of insulin resistance was calculated as HOMA-IR > 3.16.


RESULTS
Having a BMI > or = 75th percentile is associated with a high HOMA-IR levels. As the BMI percentile increases, the odds of high HOMA-IR levels increase (BMI percentile 75-84.9, OR 4.277, 95% CI 2.090-8.752; BMI percentile 85-94.9, OR 4.299, 95% CI 2.158-8.563; BMI > or = 95th percentile, OR 17.907, 95% CI 11.360-28.228).


CONCLUSIONS
Adolescents with BMI percentile of 75 to 84.9, which represents approximately 1.2 million US adolescents, have not previously been identified as having higher HOMA-IR levels.
Rodden
Ann M
AM
Medical University of South Carolina, Department of Family Medicine, Charleston, South Carolina, USA. rodden@musc.edu
Diaz
Vanessa A
VA
Mainous
Arch G
AG
Koopman
Richelle J
RJ
Geesey
Mark E
ME
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005080:Exercise Test; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009749:Nutrition Surveys; D010101:Oxygen Consumption