Slow progression of human immunodeficiency virus and hepatitis C virus disease in a cohort of coinfected children.
We carried out a retrospective study to determine the evolution of 23 vertically HIV-1/HCV coinfected children and 30 vertically HIV-1 infected children (control group). Six out of 23 HIV-1/HCV coinfected children developed AIDS versus 20 out of 30 HIV-1 children (P < 0.05). HIV-1/HCV children had a good evolution in relation to CD4 and HIV-RNA viral load. They presented higher CD8 counts than HIV-1 children during long periods, and slower progression of HCV liver disease.
Micheloud
Dariela
D
Laboratorio de Inmuno-Biología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Jensen
Julia
J
Bellón
José M
JM
Gurbindo
Dolores
D
de José
M Isabel
MI
Moreno
David
D
Ramos
José T
JT
Muñoz-Fernández
M Angeles
MA
Resino
Salvador
S
D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction; D013030:Spain; D019562:Viral Load