title: On the relationship between lens stiffness and accommodative amplitude.
abstract: The purpose of this study was to investigate the relationship between the stiffness of the material comprising the lens and the loss of accommodative amplitude with age. We used a validated mechanical model to determine the changes in the shape of the lens during accommodation and disaccommodation. The relative contribution of lens stiffness to loss of accommodative amplitude with age was determined by varying lens stiffness in the model. The changes in lens stiffness with age were based on the results of two recently published studies. In the first study we showed that lens stiffness increases exponentially with age, and in the second study we showed that there is a considerable stiffness gradient within the lens that changes with age. The results of both studies were incorporated in the mechanical model. The model showed that it is not the increasing stiffness of the lens with age, but rather the changing stiffness gradient that influences accommodative amplitude. The results show that the changing stiffness gradient in the lens may be responsible for almost the entire loss of accommodation with age.
authors.affiliation: AMO Groningen, van Swietenlaan 5, 9728 NX Groningen, The Netherlands. henk.weeber@amo-inc.com
authors.forename: Henk A
authors.initials: HA
authors.lastname: Weeber
authors.forename: Rob G L
authors.initials: RG
authors.lastname: van der Heijde
mesh_terms: D000065:Accommodation, Ocular / Q000502:physiology*; D000328:Adult; D000375:Aging / Q000502:physiology*; D001696:Biomechanical Phenomena; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology*; D008875:Middle Aged; D008954:Models, Biological