title: Infectious crystalline keratopathy caused by Serratia marcescens.
abstract: OBJECTIVE
  To report the case of a 70-year-old woman with Serratia infectious crystalline keratopathy.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  This is a report of a 70-year-old woman with a history of chronic open-angle glaucoma and trachoma with lagophthalmos, entropion, and trichiasis in both eyes who developed crystalline keratopathy after penetrating keratoplasty and cataract extraction in the right eye followed up with treatment with long-term topical steroids. Ten months after the initial penetrating keratoplasty and cataract extraction, the patient had decreased visual acuity, intense pain, and tearing in the right eye. Corneal cultures showed Serratia marcescens. Topical steroids were discontinued, and treatment with tobramycin and vancomycin ophthalmic solution every hour was initiated. Despite 1 week of aggressive therapy, there was an increase in corneal infiltrate, epithelial defects, and melting, which eventually involved the peripheral recipient cornea. Therapeutic penetrating keratoplasty, debridement of the peripheral cornea, and amniotic membrane transplantation were performed. Antibiotic agents were used postoperatively. There has been no evidence of recurrent infection. The best-corrected visual acuity improved to 6/15 at the 6-month follow-up period after the second intervention.
  
  
  CONCLUSIONS
  S. marcescens may cause infectious crystalline keratopathy after penetrating keratoplasty in patients treated with long-term topical steroids. Therapeutic penetrating keratoplasty, surgical debridement, and amniotic membrane transplantation may be necessary when the clinical response to intensive medical treatment is inadequate.
authors.affiliation: Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: Ching-Long
authors.initials: CL
authors.lastname: Chen
authors.forename: Ming-Cheng
authors.initials: MC
authors.lastname: Tai
authors.forename: Jiann-Torng
authors.initials: JT
authors.lastname: Chen
authors.forename: Chiao-Hong
authors.initials: CH
authors.lastname: Chen
authors.forename: Da-Wen
authors.initials: DW
authors.lastname: Lu
mesh_terms: D000368:Aged; D000650:Amnion / Q000637:transplantation; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003315:Cornea / Q000382:microbiology*; D003316:Corneal Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D003646:Debridement; D004359:Drug Therapy, Combination; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D005260:Female; D005469:Fluorometholone / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015948:Keratoplasty, Penetrating; D016868:Serratia Infections / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D012706:Serratia marcescens / Q000302:isolation & purification*; D014031:Tobramycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D005938:Glucocorticoids; D005469:Fluorometholone; D014031:Tobramycin