YY1 functions with INO80 to activate transcription.
Ubiquitously expressed transcription factor Yin-Yang-1 (YY1) controls expression of many genes. YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex (INO80). INO80 is recruited by YY1 to YY1-activated genes, where it functions as an essential coactivator. Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters.
Cai
Yong
Y
Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA.
Jin
Jingji
J
Yao
Tingting
T
Gottschalk
Aaron J
AJ
Swanson
Selene K
SK
Wu
Su
S
Shi
Yang
Y
Washburn
Michael P
MP
Florens
Laurence
L
Conaway
Ronald C
RC
Conaway
Joan W
JW
D000074183:ATPases Associated with Diverse Cellular Activities; D002460:Cell Line; D004265:DNA Helicases / Q000502:physiology*; D004268:DNA-Binding Proteins; D006801:Humans; D015533:Transcriptional Activation / Q000502:physiology*; D050986:YY1 Transcription Factor / Q000502:physiology*
D004268:DNA-Binding Proteins; D050986:YY1 Transcription Factor; C494698:YY1 protein, human; D000074183:ATPases Associated with Diverse Cellular Activities; D004265:DNA Helicases; C524421:INO80 protein, human