Neutrophil fatty acid composition: effect of a single session of exercise and glutamine supplementation.
The fatty acid composition of immune cells appears to contribute to variations of cell function. The independent and combined effects of a single session of exercise (SSE) and glutamine supplementation (GS) on neutrophil fatty acid composition were investigated. Compared to control (no treatment given--i.e. neither SSE or GS), single session of exercise decreased myristic, palmitic and eicosapentaenoic (EPA) acids, and increased lauric, oleic, linoleic, arachidonic (AA) and docosahexaenoic (DHA) acids whereas glutamine supplementation combined with SSE (GS+SSE) increased oleic acid. Polyunsaturated/saturated fatty acid ratio and Unsaturation index were higher in neutrophils from the SSE and GS groups as compared with control. These findings support the proposition that SSE and GS may modulate neutrophil function through alterations in fatty acid composition.
Lagranha
C J
CJ
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. lagranha@hotmail.com
Alba-Loureiro
T C
TC
Martins
E F
EF
Pithon-Curi
T C
TC
Curi
R
R
D000818:Animals; D019587:Dietary Supplements; D005227:Fatty Acids / Q000032:analysis / Q000276:immunology / Q000378:metabolism*; D005973:Glutamine / Q000494:pharmacology*; D008297:Male; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar
D005227:Fatty Acids; D005973:Glutamine