Association of classical and related inflammatory markers with high-sensitivity C-reactive protein in healthy individuals: results from the Stanislas cohort.
BACKGROUND
Although high-sensitivity C-reactive protein (hs-CRP) has emerged as a cardiovascular marker, questions arise regarding the relative information provided by other inflammatory molecules. Therefore, as a first step, we examined interrelationships between serum hs-CRP concentrations and inflammatory, adhesion and growth factors in healthy adults.


METHODS
Circulating concentrations of hs-CRP, haptoglobin, orosomucoid, interleukin-6 (IL-6), IL-8, IL-18, tumor necrosis factor-alpha (TNF-alpha), TNF-receptor II (TNF-RII), E-, P-, and L-selectins, intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1, endothelial growth factor (EGF), vascular EGF (VEGF), insulin-like growth factor-1 (IGF-1) and IGF-binding protein (IGFBP-3) were measured in 154 men and 161 women of the Stanislas cohort. Leukocyte and platelet counts were also determined.


RESULTS
Correlations were significant between hs-CRP concentrations and leukocyte and platelet counts, as well as haptoglobin, orosomucoid, IL-6, and ICAM-1 concentrations (p< or =0.001). Correlation coefficients for ICAM-1 were higher in men than in women (p< or =0.05). When stratifying subjects according to hs-CRP levels, the group with high hs-CRP levels had significantly higher haptoglobin and orosomucoid concentrations than the others, in addition to higher leukocyte counts and IL-6 concentrations in women, and platelet counts and ICAM-1 concentrations in men.


CONCLUSIONS
Further studies are warranted to explain the association pattern for hs-CRP. Partition of these factors according to their association with hs-CRP concentration opens a new perspective for choice of the best factors in terms of cardiovascular risk in relation to hs-CRP, while non-associated markers could be used to give additional information.
Berrahmoune
Hind
H
INSERM, U525, équipe 4, Nancy, France.
Herbeth
Bernard
B
Lamont
John V
JV
Lambert
Daniel
D
Blankenberg
Stefan
S
Tiret
Laurence
L
FitzGerald
Peter S
PS
Siest
Gérard
G
Visvikis-Siest
Sophie
S
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001772:Blood Cell Count; D002097:C-Reactive Protein / Q000032:analysis*; D002675:Child, Preschool; D015331:Cohort Studies; D004815:Epidermal Growth Factor / Q000032:analysis; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000473:pathology; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000032:analysis; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D007378:Interleukins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000032:analysis; D019087:Selectins / Q000032:analysis; D048069:Tumor Necrosis Factors / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
D015415:Biomarkers; D006242:Haptoglobins; D018972:Insulin-Like Growth Factor Binding Protein 3; D007378:Interleukins; D009961:Orosomucoid; D019087:Selectins; D048069:Tumor Necrosis Factors; D042461:Vascular Endothelial Growth Factor A; D018799:Intercellular Adhesion Molecule-1; D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein