title: A pediatric occurrence of crescentic glomerulonephritis associated with antineutrophil cytoplasmic antibodies and mesangial IgA deposits.
abstract: Antineutrophil cytoplasmic antibody-(ANCA) associated glomerulonephritis usually shows histopathologic features of pauciimmune crescentic glomerulonephritis and occurs late in life. We report a 14-year-old Japanese girl presenting with proteinuria, hematuria and mildly elevated serum creatinine. A renal biopsy specimen demonstrated crescentic glomerulonephritis, immunofluorescence showed mesangial IgA staining. Electron microscopic examination disclosed paramesangial deposits. Serum ANCA against myeloperoxidase (MPO) were detected at high titers. Myeloperoxidase-ANCA-related nephritis accompanied by IgA nephropathy is considered rare in childhood and teen years. Yet, if ANCA assays and detailed electron microscopic examination of renal specimens were performed routinely in patients with rapidly progressive glomerulonephritis, the diagnosis might be more frequent in young patients.
authors.affiliation: Nephrology Center, Toranomon Hospital, Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Jimbo
authors.forename: Y
authors.initials: Y
authors.lastname: Ubara
authors.forename: T
authors.initials: T
authors.lastname: Tagami
authors.forename: Y
authors.initials: Y
authors.lastname: Higa
authors.forename: T
authors.initials: T
authors.lastname: Suwabe
authors.forename: S
authors.initials: S
authors.lastname: Nakanishi
authors.forename: Y
authors.initials: Y
authors.lastname: Sogawa
authors.forename: K
authors.initials: K
authors.lastname: Nomura
authors.forename: H
authors.initials: H
authors.lastname: Kadoguchi
authors.forename: J
authors.initials: J
authors.lastname: Hoshino
authors.forename: N
authors.initials: N
authors.lastname: Sawa
authors.forename: H
authors.initials: H
authors.lastname: Katori
authors.forename: F
authors.initials: F
authors.lastname: Takemoto
authors.forename: S
authors.initials: S
authors.lastname: Hara
authors.forename: S
authors.initials: S
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Ohashi
authors.forename: K
authors.initials: K
authors.lastname: Takaichi
mesh_terms: D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic; D005260:Female; D005920:Glomerular Mesangium / Q000737:chemistry / Q000473:pathology; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007070:Immunoglobulin A