Microscopic analysis of the different regions of three Alzheimer brains aged 93, 94, and 104 years old.
The brains of three Alzheimer patients aged 93, 94, and 104 years old were analyzed. Although cell death was apparent in different cortices, the prefrontal cortex and the Broca's appeared to be hit hardest. The different CA areas of the hippocampal formation all displayed equivalent degrees of cell death but the entorhinal areas showed the most severe degree of cell degeneration. Both apoptosis and necrosis were observed in the different cerebral regions of these very old patients, as expected.
Zhu
Yonghong
Y
Department of Histology and Embryology School of Preclinical Medicine, Sun Yat-sen University, Guangzhou, China.
Xu
Jie
J
Kwong
Wing Hang
WH
Wai
Sen Mun
SM
Lam
Wai Ping
WP
Yew
David T
DT
D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000473:pathology*; D017209:Apoptosis; D001921:Brain / Q000473:pathology*; D018728:Entorhinal Cortex / Q000473:pathology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D005911:Gliosis / Q000473:pathology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D020287:In Situ Nick-End Labeling; D008297:Male; D009336:Necrosis; D017397:Prefrontal Cortex / Q000473:pathology