title: Different effect of psyllium and guar dietary supplementation on blood pressure control in hypertensive overweight patients: a six-month, randomized clinical trial.
abstract: In the setting of a six-month, open-label clinical trial, 141 consecutively enrolled, hypertensive, overweight patients were randomized to the oral ingestion of psyllium powder or guar gum 3.5 gr t.i.d., to be taken 20 min before the main two meals, or to standard diet. Both fibers improved significantly BMI, FPG, FPI, HOMA Index, HbA1c, LDL-C, and ApoB. Psyllium supplementation only exerted a significant improvement in plasma TG concentration, in SBP and DBP. In our study, six-month supplementation with psyllium fiber, but not with guar fiber nor standard diet, appears to significantly reduce both SBP and DBP in hypertensive overweight subjects.
authors.affiliation: GC Descovich Atherosclerosis Research Centre, D. Campanacci Clinical Medicine and Applied Biotechnology Dept., University of Bologna, Italy. afgcicero@cardionet.it
authors.forename: Arrigo F G
authors.initials: AF
authors.lastname: Cicero
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Derosa
authors.forename: Marco
authors.initials: M
authors.lastname: Manca
authors.forename: Marilisa
authors.initials: M
authors.lastname: Bove
authors.forename: Claudio
authors.initials: C
authors.lastname: Borghi
authors.forename: Antonio V
authors.initials: AV
authors.lastname: Gaddi
mesh_terms: D000368:Aged; D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000627:therapeutic use; D015992:Body Mass Index; D002400:Cathartics / Q000009:adverse effects / Q000627:therapeutic use; D004043:Dietary Fiber / Q000009:adverse effects / Q000627:therapeutic use; D005685:Galactans / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000503:physiopathology; D050356:Lipid Metabolism / Q000187:drug effects; D008351:Mannans / Q000009:adverse effects / Q000627:therapeutic use*; D016555:Matched-Pair Analysis; D008875:Middle Aged; D050177:Overweight; D053149:Plant Gums / Q000009:adverse effects / Q000627:therapeutic use*; D011620:Psyllium / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D019440:Anti-Obesity Agents; D002400:Cathartics; D004043:Dietary Fiber; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D011620:Psyllium; C007894:guar gum