Lipoproteins and their receptors in embryonic development: more than cholesterol clearance.
Previously, the relevance of lipoproteins and their receptors has mainly been discussed in terms of cholesterol clearance in the adult organism. Now, findings from nematodes to fruit flies to mammals all point towards novel and unexpected roles for lipoprotein metabolism in the control of key regulatory pathways in the developing embryo, including signaling through steroid hormones and throughout the hedgehog and Wnt signaling pathways. Here, we discuss the emerging view of how lipoproteins and their receptors regulate embryogenesis.
Willnow
Thomas E
TE
Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Strasse 10, D-13125 Berlin, Germany. willnow@mdc-berlin.de
Hammes
Annette
A
Eaton
Suzanne
S
D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D047108:Embryonic Development; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000502:physiology*; D051379:Mice; D018110:Receptors, Lipoprotein / Q000502:physiology*
D012739:Gonadal Steroid Hormones; D008074:Lipoproteins; D018110:Receptors, Lipoprotein; D002784:Cholesterol