title: Microbial regulatory and metabolic networks.
abstract: Reconstruction of transcriptional regulatory and metabolic networks is the foundation of large-scale microbial systems and synthetic biology. An enormous amount of information including the annotated genomic sequences and the genomic locations of DNA-binding regulatory proteins can be used to define metabolic and regulatory networks in cells. In particular, advances in experimental methods to map regulatory networks in microbial cells have allowed reliable data-driven reconstruction of these networks. Recent work on metabolic engineering and experimental evolution of microbes highlights the key role of global regulatory networks in controlling specific metabolic processes and the need to consider the integrated function of multiple types of networks for both scientific and engineering purposes.
authors.affiliation: Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412, USA.
authors.forename: Byung-Kwan
authors.initials: BK
authors.lastname: Cho
authors.forename: Pep
authors.initials: P
authors.lastname: Charusanti
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Herrgård
authors.forename: Bernhard O
authors.initials: BO
authors.lastname: Palsson
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D015966:Gene Expression Regulation, Fungal; D013058:Mass Spectrometry / Q000379:methods; D053858:Metabolic Networks and Pathways / Q000235:genetics* / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D040081:Protein Array Analysis / Q000379:methods
chemical_list: D001426:Bacterial Proteins; D005656:Fungal Proteins