title: Value of Toxoplasma gondii detection in one hundred thirty-three placentas for the diagnosis of congenital toxoplasmosis.
abstract: The placenta examination by polymerase chain reaction and mouse inoculation increased the sensitivity of the diagnosis of congenital toxoplasmosis at birth from 60% (use of serologic techniques on the newborn's blood only) to 75% (both serologic techniques and placental analysis). The specificity of Toxoplasma gondii detection in the placenta was 94.7%.
authors.affiliation: Service de Parasitologie-Mycologie, Département des Agents Infectieux; Départements de Gynécologie Obstétrique, Centre Hospitalier Universitaire, BP217, 38043, Grenoble, France. hfricker-hidalgo@chu-grenoble.fr
authors.forename: Hélène
authors.initials: H
authors.lastname: Fricker-Hidalgo
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Brenier-Pinchart
authors.forename: Jean-Patrick
authors.initials: JP
authors.lastname: Schaal
authors.forename: Véronique
authors.initials: V
authors.lastname: Equy
authors.forename: Cécile
authors.initials: C
authors.lastname: Bost-Bru
authors.forename: Hervé
authors.initials: H
authors.lastname: Pelloux
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D051379:Mice; D010920:Placenta / Q000469:parasitology*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011739:Pyrimethamine / Q000627:therapeutic use; D012680:Sensitivity and Specificity; D015572:Spiramycin / Q000627:therapeutic use; D013413:Sulfadoxine / Q000627:therapeutic use; D014122:Toxoplasma / Q000187:drug effects / Q000302:isolation & purification*; D014125:Toxoplasmosis, Congenital / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology*
chemical_list: D000890:Anti-Infective Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015572:Spiramycin; D013413:Sulfadoxine; D011739:Pyrimethamine