[Insulin resistance in type 2 diabetes patients].
Among 1052 type 2 diabetics 11 patients with insulin requirement from 102 to 138 (average 123) i.u. were selected. They were only 1% of the population. Two of them (average age 49,5 years) suffered from diabetes 4 and 6 years, had BMI 26-27 kg/m2 and were free of other metabolic syndrome manifestations. Nine patients (8 women and one man) with average parameters--62 years-old, diabetes duration 15.7 years, BMI 34,7 kg/m2 suffered from metabolic syndrome and its complications such as ischemic heart disease and/or state after stroke. The attempt of treatment 7 patients with metformin (2550 mg/24h) for 3-4 months has not caused significant decrease of daily insulin requirement.
Chodorowski
Zygmunt
Z
Katedra i Klinika Chorób Wewnetrznych, Geriatrii i Toksykologii Klinicznej, Akademii Medycznej w Gdańsku.
Sein Anand
Jacek
J
Cylkowska
Barbara
B
Hajduk
Adam
A
Kujawska-Danecka
Hanna
H
D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism; D003927:Diet, Diabetic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology; D008687:Metformin / Q000627:therapeutic use*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D011044:Poland; D017678:Sex Distribution
D007004:Hypoglycemic Agents; D007328:Insulin; D008687:Metformin