Novel functions of B cells.
T cells clearly help B cells to produce antibodies and acquire memory. Recently, B cells were found to support some T-cell responses through antigen presentation, and perhaps more importantly, through the generation of diverse T cells and lymphoid organogenesis. These new findings show that the development and function of T cells depend on B cells independently of specific antibody production.
Cascalho
Marilia
M
Transplantation Biology and the Departments of Immunology, Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. Cascalho.marilia@mayo.edu
Platt
Jeffrey L
JL
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology