title: Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner.
abstract: There is growing evidence that herpes simplex virus type 1 (HSV-1), together with the apolipoprotein E 4 (APOE4) allele, contribute to the pathogenesis of Alzheimer's disease (AD), although the mechanism of their interaction remains uncertain. Here we show that the combination of inherited APOE genotype and vertical transmission of HSV-1 confers a differential risk of brain infection. These risk factors are known to be associated with AD.
authors.affiliation: NEURON BioPharma, Drug Discovery Unit, Edificio BIC, Armilla, Granada, Spain. jburgos@neuronbp.com
authors.forename: Javier S
authors.initials: JS
authors.lastname: Burgos
authors.forename: Carlos
authors.initials: C
authors.lastname: Ramirez
authors.forename: Isabel
authors.initials: I
authors.lastname: Sastre
authors.forename: Fernando
authors.initials: F
authors.lastname: Valdivieso
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology* / Q000235:genetics / Q000821:virology; D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis / Q000097:blood; D020022:Genetic Predisposition to Disease; D006561:Herpes Simplex / Q000150:complications* / Q000635:transmission; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D051379:Mice
chemical_list: D001057:Apolipoproteins E; D004279:DNA, Viral