Vasopressin-neurophysin and DST in major depression: relationship with suicidal behavior.
The purpose of the present study was to assess if AVP-neurophysin is associated with hypercortisolemia and suicidal behaviour in depressed patients. The study included 28 patients subgrouped into suicide attempters (n=13) and nonattempters (n=15). We assessed basal AVP-neurophysins concentrations and post-dexamethasone (DST) cortisol levels. Concentrations of AVP-neurophysins did not differ between DST suppressors and nonsuppressors: 0.29+/-0.13 ng/ml vs 0.36+/-0.21 ng/ml, (F=1.1, df=1, 27, p=0.30). Suicide attempters did not differ from nonattempters for AVP-neurophysins levels. Our results fail to support a role of AVP in the early cortisol escape.
Pitchot
William
W
Department of Psychiatry, Psychoneuroendocrinology Unit, University of Liège, CHU of Liège, B-4000 Liège, Belgium.
Scantamburlo
Gabrielle
G
Pinto
Emmanuel
E
Hansenne
Michel
M
Reggers
Jean
J
Ansseau
Marc
M
Legros
Jean-Jacques
JJ
D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology; D003865:Major Depressive Disorder / Q000097:blood* / Q000503:physiopathology / Q000523:psychology*; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D009481:Neurophysins / Q000097:blood*; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data*
D009481:Neurophysins; D003907:Dexamethasone; D006854:Hydrocortisone