Modelling breast cancer: one size does not fit all.
Breast cancer is not a single disease, but is instead a collection of diseases that have distinct histopathological features, genetic and genomic variability, and diverse prognostic outcomes. Thus, no individual model would be expected to completely recapitulate this complex disease. Here, the models commonly used to investigate breast cancer including cell lines, xenografts and genetically engineered mice, are discussed to help address the question: what is the most powerful way to investigate this heterogeneous disease?
Vargo-Gogola
Tracy
T
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
Rosen
Jeffrey M
JM
D000818:Animals; D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005544:Forecasting; D051379:Mice; D008822:Mice, Transgenic; D009368:Neoplasm Transplantation; D051381:Rats