title: [Fundus autofluorescence imaging in patients with Stargardt dystrophy and fundus flavimaculatus].
abstract: OBJECTIVE
  To identify patterns of fundus autofluorescence (AF) in patients with Stargardt dystrophy and fundus flavimaculatus.
  
  
  METHODS
  20 patients in age 7 to 47 years with Stargardt dystrophy and fundus flavimaculatus, were examined. Ophthalmic evaluation included nonstandarized Snellen visual acuity, complete ophthalmic examination, fluorescein angiography and color fundus photographs. The autofluorescence images were obtained using a confocal scanning laser ophthalmoscope HRA2.
  
  
  RESULTS
  In 15 patients lack or decreased AF signal in a foveal region with punctate diffuse spots with increased and decreased AF signal extending far from the macular region were observed. In 4 patients apart from lack of the AF signal in the central area punctate spots were restricted to the macular region. In 1 patient AF image was copletely normal.
  
  
  CONCLUSIONS
  Autofluorescence imaging allows for evaluation of the area with changes on the RPE level typical for this disease and is helpful, noninvasive examination for diagnostic process in such patients. A wide variation in clinical phenotype can occur in patients with Stargardt disease and fundus flavimaculatus. Obtained different phenotypes in autofluorescence imaging may correlate with different clinical types of this disease, described in the literature.
authors.affiliation: Katedry i I Kliniki Okulistyki Akademii Medycznej w Lublinie.
authors.forename: Joanna
authors.initials: J
authors.lastname: Dolar-Szczasny
authors.forename: Jerzy
authors.initials: J
authors.lastname: Mackiewicz
authors.forename: Barbara
authors.initials: B
authors.lastname: Biziorek
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Zagórski
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005128:Eye Diseases / Q000175:diagnosis; D005260:Female; D005451:Fluorescein Angiography; D005453:Fluorescence; D005654:Fundus Oculi; D006801:Humans; D008062:Lipofuscin / Q000378:metabolism; D008266:Macula Lutea / Q000503:physiopathology*; D008268:Macular Degeneration / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods; D010641:Phenotype; D014792:Visual Acuity
chemical_list: D008062:Lipofuscin