title: Isotretinoin as a treatment for axillary granular parakeratosis.
abstract: Granular parakeratosis is a condition presenting with hyperkeratotic plaques and papules that are confined to intertriginous body sites. The exact etiology is unknown, but chemical and mechanical irritation and a moist environment are potential factors. Numerous treatments have been attempted, yielding variable results. We present a case of axillary granular parakeratosis, previously unresponsive to topical treatment, that resolved after a 2-week regimen of isotretinoin. We conclude that treatment of axillary granular parakeratosis with isotretinoin is rapid and effective and should be considered in patients with no other contraindications to isotretinoin.
authors.affiliation: University of Louisville, Kentucky, USA.
authors.forename: Aaron K
authors.initials: AK
authors.lastname: Compton
authors.forename: J Mark
authors.initials: JM
authors.lastname: Jackson
mesh_terms: D001365:Axilla; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D008875:Middle Aged; D010241:Parakeratosis / Q000188:drug therapy*
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin