title: Case of corneal melting associated with the use of topical nepafenac.
abstract: OBJECTIVE
  To report a case of corneal melting associated with the use of the topical nonsteroidal anti-inflammatory agent Nepafenac.
  
  
  METHODS
  Case report and literature review.
  
  
  RESULTS
  A 62-year-old woman with a complicated ocular history developed corneal melting associated with the use of Nepafenac. On discontinuation of Nepafenac, the melt rapidly resolved.
  
  
  CONCLUSIONS
  Topical nonsteroidal anti-inflammatory agents have been associated with corneal ulceration and stromal melts. This is, to our knowledge, the first reported case involving the new agent, Nepafenac.
authors.affiliation: Department of Ophthalmology, Loma Linda University Medical Center, Loma Linda, CA, USA.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Bekendam
authors.forename: Julio
authors.initials: J
authors.lastname: Narváez
authors.forename: Madhu
authors.initials: M
authors.lastname: Agarwal
mesh_terms: D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D044482:Benzeneacetamides / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects*; D003320:Corneal Ulcer / Q000139:chemically induced* / Q000175:diagnosis; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy; D010648:Phenylacetates / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D044482:Benzeneacetamides; D010648:Phenylacetates; C414203:nepafenac