Studies on the Stability of Streptomycin in Solution.
Streptomycin held in solution in concentrations of 100 and 1,000 microg./ml. at 10 degrees C. is stable at pH 6.0, 7.0, and 8.0 for a period of three months. The depressor effect observed in the turbidimetric assay appears to be the result of two factors, buffer salt concentration and pH, and is most marked at pH 6.0. Almost normal activity reappears at pH 8.0 even in the presence of the greater concentration of phosphates.
Oswald
E J
EJ
Nielsen
J K
JK
D002021:Buffers; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D010710:Phosphates; D012996:Solutions; D013307:Streptomycin
D002021:Buffers; D010710:Phosphates; D012996:Solutions; D013307:Streptomycin