Effect of postnatal treadmill exercise on c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers.
Maternal alcohol-intoxication during pregnancy exerts detrimental effects on fetal development and is known to influence learning ability and memory capability by altering neuronal activity in the hippocampus. c-Fos expression represents neuronal activity and plays a crucial role in the brain development. Physical exercise is known to enhance neuronal plasticity and activity. In the present study, we investigated the influence of postnatal treadmill running on the c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers. The results obtained show that maternal alcohol-intoxication suppressed c-Fos expression in the hippocampus of rat pups and that postnatal treadmill exercise enhanced c-Fos expression in the hippocampus of these rat pups. The present study suggests that exercise should be considered as a therapeutic means of countering the effects of maternal alcohol-intoxication, and that it may provide a useful strategy for enhancing the neuronal activity of children born from the mothers who abuse alcohol during pregnancy.
Sim
Young-Je
YJ
Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Kim
Hong
H
Shin
Mal-Soon
MS
Chang
Hyun-Kyung
HK
Shin
Min-Chul
MC
Ko
Il-Gyu
IG
Kim
Ki-Jeong
KJ
Kim
Tea-Soo
TS
Kim
Bo-Kyun
BK
Rhim
Yong-Taek
YT
Kim
Sangho
S
Park
Ho-Yoon
HY
Yi
Jae-Woo
JW
Lee
Sam-Jun
SJ
Kim
Chang-Ju
CJ
D000438:Alcohols / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology / Q000534:rehabilitation; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000438:Alcohols; D016760:Proto-Oncogene Proteins c-fos