title: Insulin resistance in adolescents.
abstract: OBJECTIVE
  To investigate the relationship of other body mass index (BMI) ranges with Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), a surrogate marker for insulin resistance in adolescents.
  
  
  METHODS
  Cross-sectional analysis of a nationally representative sample of 1837 nondiabetic, nonpregnant 12 to 19 year old persons from the National Health and Nutrition Examination Survey, 1999-2002. The main outcome measurement of insulin resistance was calculated as HOMA-IR > 3.16.
  
  
  RESULTS
  Having a BMI > or = 75th percentile is associated with a high HOMA-IR levels. As the BMI percentile increases, the odds of high HOMA-IR levels increase (BMI percentile 75-84.9, OR 4.277, 95% CI 2.090-8.752; BMI percentile 85-94.9, OR 4.299, 95% CI 2.158-8.563; BMI > or = 95th percentile, OR 17.907, 95% CI 11.360-28.228).
  
  
  CONCLUSIONS
  Adolescents with BMI percentile of 75 to 84.9, which represents approximately 1.2 million US adolescents, have not previously been identified as having higher HOMA-IR levels.
authors.affiliation: Medical University of South Carolina, Department of Family Medicine, Charleston, South Carolina, USA. rodden@musc.edu
authors.forename: Ann M
authors.initials: AM
authors.lastname: Rodden
authors.forename: Vanessa A
authors.initials: VA
authors.lastname: Diaz
authors.forename: Arch G
authors.initials: AG
authors.lastname: Mainous
authors.forename: Richelle J
authors.initials: RJ
authors.lastname: Koopman
authors.forename: Mark E
authors.initials: ME
authors.lastname: Geesey
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005080:Exercise Test; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009749:Nutrition Surveys; D010101:Oxygen Consumption