[Acute intoxication with zaleplon--a case report].
There has been little data in the medical literature about intoxication with a new hypnotic agent zaleplon. The zaleplon, chemically N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamid, is a selective agonist of the benzodiazepine omega 1 receptor subtype. The case of a 15-year-old female who eat 60 mg of zaleplon (1.2 mg/kg) because of suicidal attempt was described. At the admission to the hospital the somnolence, blurred speech, slowdown, ataxia, tachycardia and hypokalaemia were observed. The child was treated symptomatically, and discharged from the hospital for further psychologic treatment after 36 hours.


CONCLUSIONS
Acute intoxication with zaleplon had mild clinical course. The signs of intoxications were drowsiness, blurred speech, ataxia, tachycardia, dizziness, confusion and vomiting. The described case required only symptomatic treatment.
Sein Anand
Jacek
J
Katedra i Klinika Chorób Wewnetrznych, Geriatrii i Toksykologii Klinicznej, Akademii Medycznej w Gdańsku. jsanand@amg.gda.pl
Chodorowski
Zygmunt
Z
Hajduk
Adam
A
D000081:Acetamides / Q000506:poisoning*; D000293:Adolescent; D001259:Ataxia / Q000139:chemically induced / Q000628:therapy; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced / Q000628:therapy; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning*; D011041:Poisoning / Q000175:diagnosis* / Q000628:therapy; D011743:Pyrimidines / Q000506:poisoning*; D013406:Suicide, Attempted; D013610:Tachycardia / Q000139:chemically induced / Q000628:therapy; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced / Q000628:therapy
D000081:Acetamides; D006993:Hypnotics and Sedatives; D011743:Pyrimidines; C085665:zaleplon