title: [An analysis of the fundus changes in families with high myopia].
abstract: OBJECTIVE
  Of this study is to present fundus changes in members of families with high myopia.
  
  
  METHODS
  Detailed clinical examination of the enrolled subjects have been performed in the high myopia families. Both affected (presented with high myopia) and unaffected individuals (without high myopia) are given an ophthalmologic examination: best-corrected visual acuity testing, intraocular pressure examination, fundoscopy, axial length determination (using ultrasonography), refractometry.
  
  
  RESULTS
  In the 19 high myopia families, 152 individuals were carefully examined. In 11 individuals retinal detachment have been observed. Additionally, myopic degeneration of the central retina (15 cases), degeneration of the peripherial retina (20 subjects), AMD (4 subjects), hypertrophy of the RPE (2 subjects), CNV (1 case), striae medullares (1 case) and macular foramen (1 case), have been identified.
  
  
  CONCLUSIONS
  In the affected individuals (presented with high myopia) changes of the eye fundus and retinal detachment were more frequently observed comparing to unaffected members of the families without high myopia. In unaffected individuals genetic factor seems to play insignificant role in apperance of fundus. Changes within central retina in the high myopia individuals may conduce to severe visual impairment.
authors.affiliation: Katedry i Kliniki Okulistyki Akademii Medycznej w Poznaniu.
authors.forename: Agata
authors.initials: A
authors.lastname: Frajdenberg
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pecold
authors.forename: Monika
authors.initials: M
authors.lastname: Podfigurna-Musielak
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Rydzanicz
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Mrugacz
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Leal
authors.forename: Bassem A
authors.initials: BA
authors.lastname: Bejjani
authors.forename: Marzena
authors.initials: M
authors.lastname: Gajecka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications* / Q000175:diagnosis*; D009887:Ophthalmoscopy; D012029:Refraction, Ocular; D012162:Retinal Degeneration / Q000209:etiology; D012163:Retinal Detachment / Q000209:etiology; D012164:Retinal Diseases / Q000175:diagnosis* / Q000209:etiology*; D012167:Retinal Perforations / Q000209:etiology; D012720:Severity of Illness Index; D014792:Visual Acuity