title: Highly enantioselective direct aldol reaction catalyzed by cinchona derived primary amines.
abstract: Highly enantioselective aldol reactions of aldehydes with cyclic ketones catalyzed by a primary amine derived from cinchonine are reported. Aromatic aldehydes reacted with various cyclic ketones cleanly to afford the anti-aldol adducts in up to 99% yield, with good diastereoselectivities (up to 9 : 1) and excellent enantioselectivities (up to 99% ee).
authors.affiliation: College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, 637002, China.
authors.forename: Bao-Lei
authors.initials: BL
authors.lastname: Zheng
authors.forename: Quan-Zhong
authors.initials: QZ
authors.lastname: Liu
authors.forename: Chuan-Sheng
authors.initials: CS
authors.lastname: Guo
authors.forename: Xue-Lian
authors.initials: XL
authors.lastname: Wang
authors.forename: Long
authors.initials: L
authors.lastname: He