Highly enantioselective direct aldol reaction catalyzed by cinchona derived primary amines.
Highly enantioselective aldol reactions of aldehydes with cyclic ketones catalyzed by a primary amine derived from cinchonine are reported. Aromatic aldehydes reacted with various cyclic ketones cleanly to afford the anti-aldol adducts in up to 99% yield, with good diastereoselectivities (up to 9 : 1) and excellent enantioselectivities (up to 99% ee).
Zheng
Bao-Lei
BL
College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, 637002, China.
Liu
Quan-Zhong
QZ
Guo
Chuan-Sheng
CS
Wang
Xue-Lian
XL
He
Long
L