Changes in serum adenosine deaminase activity during normal pregnancy.
Adenosine deaminase (ADA), an enzyme essential for the differentiation of lymphoid cells, has been used for monitoring diseases with altered immunity. The purpose of this study was to investigate the changes in serum ADA activity throughout normal pregnancy. We measured the catalytic values of serum ADA from 202 normal pregnant women using a commercial kit. Subjects were divided into four groups according to the gestational age in weeks (Gwks) (Group I: 5-9 Gwks [n=58]; Group II: 15-20 Gwks [n= 63]; Group III: 24-30 Gwks [n=34]; Group IV: 30-39 Gwks [n=47]). The serum ADA levels for the Groups I, II, III, and IV were as follows: 20.1 +/- 6.9 IU/L, 20.0 +/- 7.6 IU/L, 37.9 +/- 19.9 IU/L, and 24.5 +/- 8.6 IU/L, respectively. The serum ADA activity of group III was significantly higher than the other groups (p<0.05). However, there was no significant correlation between the Gwks and the serum ADA activity. Furthermore, other parameters, such as maternal age (p=0.29), gestational age at delivery (p=0.07), delivery mode (p=0.39), and birth weight (p=0.59) had no correlation with ADA activity. Reference values of serum ADA in normal pregnancy may provide important database for making clinical decisions in pregnancies complicated by conditions where cellular immunity has been altered.
Lee
Soo Jin
SJ
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
Hwang
Han Sung
HS
Kim
Bit Na Rae
BN
Kim
Min A
MA
Lee
Jae Wook
JW
Park
Yong Won
YW
Kim
Young Han
YH
D000241:Adenosine / Q000378:metabolism; D000243:Adenosine Deaminase / Q000097:blood* / Q000378:metabolism*; D000328:Adult; D000704:Analysis of Variance; D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007288:Inosine / Q000378:metabolism; D016015:Logistic Models; D008423:Maternal Age; D011247:Pregnancy; D013379:Substrate Specificity
D007288:Inosine; D000243:Adenosine Deaminase; D000241:Adenosine