title: Effect of postnatal treadmill exercise on c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers.
abstract: Maternal alcohol-intoxication during pregnancy exerts detrimental effects on fetal development and is known to influence learning ability and memory capability by altering neuronal activity in the hippocampus. c-Fos expression represents neuronal activity and plays a crucial role in the brain development. Physical exercise is known to enhance neuronal plasticity and activity. In the present study, we investigated the influence of postnatal treadmill running on the c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers. The results obtained show that maternal alcohol-intoxication suppressed c-Fos expression in the hippocampus of rat pups and that postnatal treadmill exercise enhanced c-Fos expression in the hippocampus of these rat pups. The present study suggests that exercise should be considered as a therapeutic means of countering the effects of maternal alcohol-intoxication, and that it may provide a useful strategy for enhancing the neuronal activity of children born from the mothers who abuse alcohol during pregnancy.
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Young-Je
authors.initials: YJ
authors.lastname: Sim
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Mal-Soon
authors.initials: MS
authors.lastname: Shin
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Chang
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Shin
authors.forename: Il-Gyu
authors.initials: IG
authors.lastname: Ko
authors.forename: Ki-Jeong
authors.initials: KJ
authors.lastname: Kim
authors.forename: Tea-Soo
authors.initials: TS
authors.lastname: Kim
authors.forename: Bo-Kyun
authors.initials: BK
authors.lastname: Kim
authors.forename: Yong-Taek
authors.initials: YT
authors.lastname: Rhim
authors.forename: Sangho
authors.initials: S
authors.lastname: Kim
authors.forename: Ho-Yoon
authors.initials: HY
authors.lastname: Park
authors.forename: Jae-Woo
authors.initials: JW
authors.lastname: Yi
authors.forename: Sam-Jun
authors.initials: SJ
authors.lastname: Lee
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000438:Alcohols / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology / Q000534:rehabilitation; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000438:Alcohols; D016760:Proto-Oncogene Proteins c-fos