title: Morphine-mediated deterioration of oxidative stress leads to rapid disease progression in SIV/SHIV-infected macaques.
abstract: Oxidative stress is well documented in HIV infection, but the effect of concomitant substance abuse is largely unknown. We studied oxidative stress in our macaque model of morphine abuse and AIDS. In plasma, we found an approximately 50% decrease in catalase activity with morphine dependence that was exacerbated by infection in rapid progressors. Superoxide dismutase was decreased by a similar degree, but only in the presence of both morphine and viral infection. The loss of these antioxidant systems was coincident with significantly increased plasma malondialdehyde upon viral infection that displayed a synergistic increase in conjunction with morphine and rapid disease.
authors.affiliation: AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pérez-Casanova
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Noel
authors.forename: Vanessa
authors.initials: V
authors.lastname: Rivera-Amill
authors.forename: Kazim
authors.initials: K
authors.lastname: Husain
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000818:Animals; D018791:CD4 Lymphocyte Count; D002374:Catalase / Q000097:blood; D018450:Disease Progression; D006678:HIV; D008251:Macaca; D008315:Malondialdehyde / Q000097:blood; D009021:Morphine Dependence / Q000150:complications*; D018384:Oxidative Stress; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications / Q000378:metabolism* / Q000821:virology; D015302:Simian Immunodeficiency Virus; D013482:Superoxide Dismutase / Q000097:blood; D019562:Viral Load
chemical_list: D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase