title: Chiral bisformamides as effective organocatalysts for the asymmetric one-pot, three-component strecker reaction.
abstract: C2-symmetric chiral bisformamides have been shown to catalyze the asymmetric one-pot, three-component Strecker reaction, which produced the alpha-amino nitriles in excellent yields (up to 99%) with good enantioselectivities (up to 86% ee). Optically pure products could be obtained after a single recrystallization. A possible transition state (TS 1) has been proposed to explain the origin of asymmetric inductivity and reactivity according to the geometry of catalyst 2a optimized at the B3LYP/6-31G(d) level and the absolute configuration of product 4a.
authors.affiliation: Key Laboratory of Green Chemistry & Technology (Sichuan University), Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
authors.forename: Yuehong
authors.initials: Y
authors.lastname: Wen
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiong
authors.forename: Lu
authors.initials: L
authors.lastname: Chang
authors.forename: Jinglun
authors.initials: J
authors.lastname: Huang
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D005559:Formamides / Q000737:chemistry*; D009570:Nitriles / Q000138:chemical synthesis*
chemical_list: D000588:Amines; D005559:Formamides; D009570:Nitriles