Beta-amino acid-containing hybrid peptides--new opportunities in peptidomimetics.
Hybrid peptides consisting of alpha-amino acids with judiciously placed beta-amino acids show great promise as peptidomimetics in an increasing range of therapeutic applications. This reflects a combination of increased stability, high specificity and relative ease of synthesis.
Aguilar
Marie-Isabel
MI
Department of Biochemistry & Molecular Biology, Monash University, PO Box 13d, Victoria, 3800, Australia.
Purcell
Anthony W
AW
Devi
Romila
R
Lew
Rebecca
R
Rossjohn
Jamie
J
Smith
A Ian
AI
Perlmutter
Patrick
P
D000596:Amino Acids / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry; D008285:Major Histocompatibility Complex; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation
D000596:Amino Acids; D004791:Enzyme Inhibitors; D010455:Peptides