title: Megestrol acetate in cachexia and anorexia.
abstract: The aim is to review major clinical trials that have used megestrol acetate (MA) in the treatment of cachexia across several disease states. A review of general usage and potential side-effects are discussed. A theory that the newly approved nanocrystal formation of MA can better deliver this potent medication for treatment will also be reviewed.
authors.affiliation: Northport VAMC, Geriatric division, Northport, NY 11768, USA. shingshing.yeh@med.va.gov
authors.forename: Shing-Shing
authors.initials: SS
authors.lastname: Yeh
authors.forename: Michael W
authors.initials: MW
authors.lastname: Schuster
mesh_terms: D000855:Anorexia / Q000188:drug therapy*; D002100:Cachexia / Q000188:drug therapy*; D002986:Clinical Trials as Topic / Q000639:trends*; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D019290:Megestrol Acetate / Q000009:adverse effects / Q000737:chemistry* / Q000627:therapeutic use*; D053758:Nanoparticles / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D019290:Megestrol Acetate