Induced Hypersensitivity to Cold.
Extreme hypersensitivity to cold can be induced in the rat by a single subcutaneous injection of carrageenin. In animals so treated, exposure to cold induces necrotizing thrombohemorrhagic lesions in the nose, paws, and tail, accompanied by renal lesions resembling those of the generalized Sanarelli-Shwartzman phenomenon. The same treatment elicits hemorrhagic necroses of transplants of Murphy lymphosarcomas in rats.
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