Intramolecular cation-pi interaction in organic synthesis.
Controlling molecular conformation is a significantly important issue in a wide variety of organic reactions because the ground state structure is significantly responsible for the transition one. As observed in enzymes and proteins, the cation-pi interaction plays a key role in the formation of the tertiary structure and the biochemical processes. Therefore, the cation-pi interaction would be a promising conformation-controlling tool not only in large molecules, but also in small molecules due to its stronger interaction force. This article describes the utility of the intramolecular cation-pi interaction in various organic syntheses with evidence for the existence of the cation-pi interactions.
Yamada
Shinji
S
Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan. yamada.shinji@ocha.ac.jp
D002412:Cations / Q000737:chemistry*; D008958:Models, Molecular; D009930:Organic Chemicals / Q000138:chemical synthesis*; D013237:Stereoisomerism
D002412:Cations; D009930:Organic Chemicals