Acetaminophen hepatotoxicity.
Acetaminophen is a commonly used antipyretic and analgesic agent. It is safe when taken at therapeutic doses; however, overdose can lead to serious and even fatal hepatotoxicity. The initial metabolic and biochemical events leading to toxicity have been well described, but the precise mechanism of cell injury and death is unknown. Prompt recognition of overdose, aggressive management, and administration of N-acetylcysteine can minimize hepatotoxicity and prevent liver failure and death. Liver transplantation can be lifesaving for those who develop acute liver failure.
Larson
Anne M
AM
Division of Gastroenterology, Hepatology Section, University of Washington, 1959 NE Pacific Street, Box 356174, Seattle, WA 98195-6174, USA. amlarson@u.washington.edu
D000082:Acetaminophen / Q000009:adverse effects* / Q000378:metabolism / Q000506:poisoning; D000111:Acetylcysteine / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury; D062787:Drug Overdose; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology
D000082:Acetaminophen; D000111:Acetylcysteine