title: Comparison of ROC umbrella volumes with an application to the assessment of lung cancer diagnostic markers.
abstract: Receiver operating characteristic (ROC) analysis is widely used to assess the ability of diagnostic markers to correctly classify into one of two disease classes. ROC surfaces and umbrella surfaces generalize the utility of ROC analysis when there are three disease classes. Identification of lung cancer diagnostic markers is an active area of research since prognosis for those diagnosed with lung cancer is so poor and there is not an accurate method for early detection of lung cancer. A study conducted for the assessment of DNA methylation markers motivated the comparison of ROC umbrella surfaces which is developed in this article using U-statistics and bootstrap methodology.
authors.affiliation: Division of Biostatistics, University of Southern California Keck School of Medicine, 440 E. Huntington Dr, 4th floor, Arcadia, CA 91006, USA. talonzo@childrensoncologygroup.org
authors.forename: Todd A
authors.initials: TA
authors.lastname: Alonzo
authors.forename: Christos T
authors.initials: CT
authors.lastname: Nakas
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001699:Biometry / Q000379:methods*; D019175:DNA Methylation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor