Bone morphogenetic proteins and their receptors in the eye.
The human genome encodes at least 42 different members of the transforming growth factor-beta superfamily of growth factors. Bone morphogenetic proteins (BMPs) are the largest subfamily of proteins within the transforming growth factor-beta superfamily and are involved in numerous cellular functions including development, morphogenesis, cell proliferation, apoptosis, and extracellular matrix synthesis. This article first reviews BMPs and BMP receptors, BMP signaling pathways, and mechanisms controlling BMP signaling. Second, we review BMP and BMP receptor expression during embryonic ocular development/ differentiation and in adult ocular tissues. Lastly, future research directions with respect to BMP, BMP receptors, and ocular tissues are suggested.
Wordinger
Robert J
RJ
Department of Cell Biology and Genetics, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107-2699, USA. rwording@hsc.unt.edu
Clark
Abbot F
AF
D017209:Apoptosis / Q000502:physiology; D052004:Bone Morphogenetic Protein Receptors / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D049109:Cell Proliferation; D005109:Extracellular Matrix / Q000235:genetics / Q000378:metabolism; D005123:Eye / Q000196:embryology / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D015894:Genome, Human; D006801:Humans; D005810:Multigene Family; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000235:genetics
D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta; D052004:Bone Morphogenetic Protein Receptors