Discovery and development of sulforaphane as a cancer chemopreventive phytochemical.
Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer-related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis. We review its discovery and development as a cancer chemopreventive agent with the intention of encouraging further research on this important compound and facilitating the identification and development of new phytochemicals for cancer prevention.
Zhang
Yuesheng
Y
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. yuesheng.zhang@roswellpark.org
Tang
Li
L
D000818:Animals; D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D017879:Isothiocyanates; D009369:Neoplasms / Q000517:prevention & control*; D013454:Sulfoxides; D013861:Thiocyanates / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*
D016588:Anticarcinogenic Agents; D017879:Isothiocyanates; D013454:Sulfoxides; D013861:Thiocyanates; C016766:sulforaphane