title: Cardiac memory induced by QRS widening due to propafenone toxicity.
abstract: Propafenone toxicity can cause significant QRS widening and markedly abnormal ventricular activation pattern. Aberrant ventricular activation upon its resolution is known to produce persistent T-wave changes known as "cardiac memory" (CM). A 74-year-old woman presented with a severely abnormal electrocardiogram consistent with propafenone toxicity. As her QRS complex narrowed, T-wave inversions developed with the T-wave axis and resolution kinetics consistent with CM. Abnormal ventricular activation due to propafenone toxicity can result in CM development.
authors.affiliation: Harvard-Thorndike Electrophysiology Institute,Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: John V
authors.initials: JV
authors.lastname: Wylie
authors.forename: Peter
authors.initials: P
authors.lastname: Zimetbaum
authors.forename: Mark E
authors.initials: ME
authors.lastname: Josephson
authors.forename: Alexei
authors.initials: A
authors.lastname: Shvilkin
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D006801:Humans; D011405:Propafenone / Q000009:adverse effects*; D014693:Ventricular Fibrillation / Q000139:chemically induced* / Q000175:diagnosis* / Q000517:prevention & control
chemical_list: D000889:Anti-Arrhythmia Agents; D011405:Propafenone