[Fenvalerate affects sperm motility in SD rats].
OBJECTIVE
To observe the direct effects of fenvalerate (Fen) on sperm motility in SD rats.


METHODS
Sperm were isolated from caudal epididymides of healthy adult male rats with the diffusion method. The motility parameters of the isolated sperm, such as VCL, VSL, VAP, BCF, STR and LIN, were monitored by computer-assisted sperm analysis (CASA) system after 1, 2 and 4 h Fen-exposure in vitro at concentrations of 0, 1, 4, 16 and 64 micromol/L respectively.


RESULTS
After 1 and 2 h Fen-exposure, VSL, BCF, STR and LIN decreased significantly at 64 micromol/L compared with the control group. After 4 h Fen-exposure, the motility parameters VCL, VSL, BCF, STR and LIN dropped progressively at 64 micromol/L, and VCL declined markedly at 16 micromol/L. However, only VCL and STR showed alterations in a time-response manner.


CONCLUSIONS
Fen may affect the caudal epididymal sperm and produce a direct toxic effect on sperm motility in SD rats.
Song
Ling
L
Institute of Toxicology, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Wang
Yu-Bang
YB
Sun
Hong
H
Gu
Ai-Hua
AH
Sun
Yang
Y
Wang
Xin-Ru
XR
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000633:toxicity; D008297:Male; D009570:Nitriles / Q000633:toxicity*; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects*
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017690:fenvalerate