1H magnetic resonance spectroscopy study of thalamus in treatment resistant depressive patients.
Treatment-resistant depression (TRD) is a common clinical problem, and represents a considerable challenge to treatment, however, the pathogenesis of this disease is poorly understood. Thalamus is generally believed to have a role in the pathophysiology of depression. In this study, we adopted 1.5T (1)H magnetic resonance spectroscopy ((1)H MRS) to examine possible alterations of thalamus metabolism in 20 adult TRD patients. Our results suggested there might be damage and loss of neurons, as well as membrane phospholipids associated metabolism abnormality in the TRD thalamus.
Mu
Jun
J
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, The Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing, 400016, China.
Xie
Peng
P
Yang
Ze-Song
ZS
Yang
De-Lan
DL
Lv
Fa-Jin
FJ
Luo
Tian-You
TY
Li
Yong
Y
D000328:Adult; D001224:Aspartic Acid / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D003863:Depression / Q000175:diagnosis*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons; D013788:Thalamus / Q000473:pathology*
D011522:Protons; D001224:Aspartic Acid; D003401:Creatine; D002794:Choline