Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy.
We analysed the influence of mesial temporal lobe epilepsy on the thickness of the corpus callosum (CC) in a large sample of well-characterized patients (n = 96) and healthy controls (n = 28). In particular, we investigated whether callosal structures are differentially affected depending on the affected hemisphere and age of epilepsy onset. Overall, we observed that epilepsy is associated with a decreased thickness in posterior callosal regions. Patients with an early onset, especially patients with left onset, additionally exhibited a smaller callosal thickness in more anterior and midbody regions. These findings may reflect non-specific as well as specific effects of temporal lobe epilepsy on CC development and interhemispheric connectivity.
Weber
Bernd
B
Department of Epileptology, University of Bonn, Germany. bernd.weber@ukb.uni-bonn.de
Luders
Eileen
E
Faber
Jennifer
J
Richter
Sabine
S
Quesada
Carlos M
CM
Urbach
Horst
H
Thompson
Paul M
PM
Toga
Arthur W
AW
Elger
Christian E
CE
Helmstaedter
Christoph
C
D000328:Adult; D017668:Age of Onset; D001284:Atrophy / Q000473:pathology; D001931:Brain Mapping / Q000379:methods; D003337:Corpus Callosum / Q000473:pathology*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged