title: Dendrimers as drug carriers: applications in different routes of drug administration.
abstract: Dendrimers have successfully proved themselves as useful additives in different routes of drug administration because they can render drugs greater water-solubility, bioavailability, and biocompatibility. This review demonstrated the potential of dendrimers to be applied in these detailed routes with particular reference to intravenous, oral, transdermal, and ocular delivery systems. As a necessary introduction, the structures, synthesis, and properties of dendrimers were presented. Furthermore, the interaction mechanisms between dendrimers and drug molecules, including simple encapsulation, electrostatic interaction, and covalent conjugation, were elaborated.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. yycheng@mail.ustc.edu.cn
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Cheng
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Xu
authors.forename: Minglu
authors.initials: M
authors.lastname: Ma
authors.forename: Tongwen
authors.initials: T
authors.lastname: Xu
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry*; D004339:Drug Compounding; D004563:Electrochemistry; D006801:Humans; D053758:Nanoparticles; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; D004364:Pharmaceutical Preparations