title: Advances in the medical management of osteoporosis.
abstract: Osteoporosis is a skeletal disorder characterised by compromised bone strength predisposing to increased risk of fracture, which is rapidly reaching epidemic proportions as the population ages. Many patients presenting with a fracture caused by a fall from standing height or less are not on any kind of therapy and many patients who sustain these fragility fractures are not started on therapy by their orthopaedic surgeon. In 2004, the United States Surgeon General released a report on osteoporosis recommending that physicians adopt a pyramidal approach to therapy. The base of the pyramid includes calcium, vitamin D, physical therapy and fall prevention. The second level calls for management or elimination of secondary causes of osteoporosis. The third level consists of treatment with either anti-resorptive or anabolic medications. The orthopaedic surgeon is in an ideal position to diagnose fragility fractures and suggest treatment in the hope of preventing future fractures. Anti-resorptive and anabolic therapies currently available are discussed.
authors.affiliation: University of Rochester School of Medicine and Dentistry, Rochester, New York 14620, USA. stephen_kates@ormc.rochester.edu
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Kates
authors.forename: Olivia S
authors.initials: OS
authors.lastname: Kates
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Mendelson
mesh_terms: D000058:Accidental Falls / Q000517:prevention & control; D015519:Bone Density / Q000502:physiology*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D019379:Teriparatide / Q000627:therapeutic use; D014481:United States; D014732:Vibration / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D019379:Teriparatide; D014807:Vitamin D