title: Renal failure with granulomatous interstitial nephritis and diffuse leukemic renal infiltration in chronic lymphocytic leukemia.
abstract: Renal dysfunction is uncommon in patients with leukemic infiltration of the kidney due to Chronic Lymphocytic Leukanemia (CLL). Granulomatous interstitial nephritis (GIN) is also rare, but a characteristic hallmark of certain diseases such as sarcoidosis and tuberculosis. GIN has been associated with medications, infections, inflammation, Wegener's granulomatosis, and jejuno-ileal bypass. GIN combined with leukemic infiltration by CLL is very uncommon. We present a 72-year-old male with Binet stage A CLL who developed progressive renal failure over a period of four years requiring maintenance dialysis. During the course of his illness, he underwent renal biopsies at different time intervals, revealing varying degrees of involvement by GIN together with leukemic infiltration.
authors.affiliation: Department of Haematology, Guys' & St Thomas' Foundation Trust, London, UK. anil.kamat@gstt.nhs.uk
authors.forename: Anil V
authors.initials: AV
authors.lastname: Kamat
authors.forename: David
authors.initials: D
authors.lastname: Goldsmith
authors.forename: Patrick
authors.initials: P
authors.lastname: O'Donnell
authors.forename: Jon
authors.initials: J
authors.lastname: van der Walt
authors.forename: Robert
authors.initials: R
authors.lastname: Carr
mesh_terms: D000368:Aged; D006801:Humans; D007668:Kidney / Q000473:pathology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000473:pathology*; D017254:Leukemic Infiltration; D008297:Male; D009395:Nephritis, Interstitial / Q000209:etiology* / Q000473:pathology; D051437:Renal Insufficiency / Q000209:etiology*