title: In vitro angiotensin converting enzyme inhibiting activity of Salsola oppositifolia Desf., Salsola soda L. and Salsola tragus L.
abstract: In order to support scientifically the traditional use of Salsola species in the treatment of hypertension, this study was designed to evaluate the hypotensive properties of Salsola oppositifolia, S. soda and S. tragus. In vitro bio-assay based on the measured enzymatic cleavage of the chromophore-fluorophore-labelled substrate dansyltriglycine into dansylglycine and diglycine by angiotensin converting enzyme (ACE) was performed. EtOAc extracts of S. oppositifolia and S. soda exhibited an interesting activity with an IC(50) of 181.04 and 284.27 microg mL(-1), respectively.
authors.affiliation: Department of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende, CS, Italy. mr.loizzo@unical.it
authors.forename: Monica Rosa
authors.initials: MR
authors.lastname: Loizzo
authors.forename: Rosa
authors.initials: R
authors.lastname: Tundis
authors.forename: Giancarlo Antonio
authors.initials: GA
authors.lastname: Statti
authors.forename: Nicodemo Giuseppe
authors.initials: NG
authors.lastname: Passalacqua
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Peruzzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichini
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis*; D010936:Plant Extracts / Q000494:pharmacology; D031248:Salsola / Q000737:chemistry*; D013045:Species Specificity; D013634:Tannins / Q000032:analysis
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D010936:Plant Extracts; D013634:Tannins