Integration of jugular venous return and circle of Willis in a theoretical human model of selective brain cooling.
A three-dimensional mathematical model was developed to examine the induction of selective brain cooling (SBC) in the human brain by intracarotid cold (2.8 degrees C) saline infusion (ICSI) at 30 ml/min. The Pennes bioheat equation was used to propagate brain temperature. The effect of cooled jugular venous return was investigated, along with the effect of the circle of Willis (CoW) on the intracerebral temperature distribution. The complete CoW, missing A1 variant (mA1), and fetal P1 variant (fP1) were simulated. ICSI induced moderate hypothermia (defined as 32-34 degrees C) in the internal carotid artery (ICA) territory within 5 min. Incorporation of the complete CoW resulted in a similar level of hypothermia in the ICA territory. In addition, the anterior communicating artery and ipsilateral posterior communicating artery distributed cool blood to the contralateral anterior and ipsilateral posterior territories, respectively, imparting mild hypothermia (35 and 35.5 degrees C respectively). The mA1 and fP1 variants allowed for sufficient cooling of the middle cerebral territory (30-32 degrees C). The simulations suggest that ICSI is feasible and may be the fastest method of inducing hypothermia. Moreover, the effect of convective heat transfer via the complete CoW and its variants underlies the important role of CoW anatomy in intracerebral temperature distributions during SBC.
Neimark
Matthew A
MA
Dept. of Biomedical Engineering, Columbia Univ., 1210 Amsterdam Ave., New York, NY 10027, USA. man2003@columbia.edu
Konstas
Angelos-Aristeidis
AA
Laine
Andrew F
AF
Pile-Spellman
John
J
D001783:Blood Flow Velocity; D001831:Body Temperature; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D002339:Carotid Arteries; D002560:Cerebrovascular Circulation; D002941:Circle of Willis / Q000503:physiopathology*; D003198:Computer Simulation; D005240:Feasibility Studies; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007262:Infusions, Intravenous; D007601:Jugular Veins / Q000503:physiopathology*; D008955:Models, Cardiovascular; D012039:Regional Blood Flow; D012965:Sodium Chloride / Q000008:administration & dosage; D013997:Time Factors
D012965:Sodium Chloride