title: Epidemiology of chronic atrophic gastritis: population-based study among 9444 older adults from Germany.
abstract: BACKGROUND
  Epidemiological data on chronic atrophic gastritis from general population samples are sparse in Germany.
  
  
  OBJECTIVE
  To assess prevalence of chronic atrophic gastritis according to potential risk factors and clinical outcomes in a large-scale population-based study.
  
  
  METHODS
  In the baseline examination of ESTHER, a population-based cohort study conducted in Germany, serological measurements of pepsinogen (PG) I and II and Helicobacter pylori antibodies were taken in 9444 women and men aged 50-74 years. Information on potential risk factors and medical history were obtained by questionnaire.
  
  
  RESULTS
  With the definition used in the EUROGAST study (PG I < 25 ng/mL), prevalence of chronic atrophic gastritis increased from 4.8% in age group 50-54 to 8.7% in age group 70-74. An alternative definition of chronic atrophic gastritis (PG I < 70 ng/mL and PG I/PG II < 3), used in multiple studies from Japan, revealed a greater increase with age (from 2.7% to 9.1%) and a strong association with H. pylori infection (adjusted odds ratio: 2.9, 95% confidence interval: 2.4-3.7). With both definitions, a strong inverse association with heartburn was observed.
  
  
  CONCLUSIONS
  Overall chronic atrophic gastritis prevalence is low among older adults in Germany, but it strongly increases with age and H. pylori infection.
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
authors.forename: M N
authors.initials: MN
authors.lastname: Weck
authors.forename: C
authors.initials: C
authors.lastname: Stegmaier
authors.forename: D
authors.initials: D
authors.lastname: Rothenbacher
authors.forename: H
authors.initials: H
authors.lastname: Brenner
mesh_terms: D017677:Age Distribution; D000368:Aged; D005260:Female; D005757:Gastritis, Atrophic / Q000453:epidemiology*; D005858:Germany / Q000453:epidemiology; D016481:Helicobacter Infections / Q000150:complications* / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000032:analysis / Q000652:urine; D020115:Pepsinogen C / Q000378:metabolism*; D015995:Prevalence; D011795:Surveys and Questionnaires
chemical_list: D020115:Pepsinogen C; D020116:Pepsinogen A