Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives.
A new series of diarylmethylnapthyloxy ethylamines were synthesized by aminoalkylation of diarylmethylnaphthols which were obtained by Friedel-Crafts alkylation on 1- and 2-naphthols using diarylcarbinols as the alkylating agents. The title compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H(37)R(v) in vitro and showed MIC in the range of 3.12-25 microg/ml.
Das
Sajal Kumar
SK
Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India.
Panda
Gautam
G
Chaturvedi
Vinita
V
Manju
Y S
YS
Gaikwad
Anil K
AK
Sinha
Sudhir
S
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D008745:Methylation; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009284:Naphthols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D009284:Naphthols