HLA-B*0749N: the first HLA-B*07 null allele.
In the present article, we report the identification of the first HLA-B*07 null allele found in a Polish patient awaiting a kidney allograft. A discrepant result obtained between serological typing (HLA-B "blank") and high-resolution molecular typing using PCR-SSP method (HLA-B*070201 allele) suggested the presence of a null allele. Genomic DNA sequencing of the HLA-B*07 allele revealed a single nucleotide substitution at the 3' end of the exon 4 leading to a premature stop codon.
Perrier
P
P
Laboratoire d'Histocompatibilité, CHU Brabois, 54511 Vandoeuvre-les-Nancy Cedex, France. p.perrier@chu-nancy.fr
Dormoy
A
A
Proust
B
B
Froelich
N
N
Bastien
A
A
D000328:Adult; D000483:Alleles; D001483:Base Sequence; D015235:HLA-B Antigens / Q000235:genetics*; D015793:HLA-B7 Antigen; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide
D015235:HLA-B Antigens; C425023:HLA-B*07 antigen; D015793:HLA-B7 Antigen