For IRES trans-acting factors, it is all about location.
The translation of many proteins involved in transcription, cell cycle progression, apoptosis and cell survival is mediated by internal ribosome entry sites (IRESs) present within the 5'-untranslated regions (5'-UTRs) of their messenger RNA molecules (mRNAs). Several recent reports now demonstrate that the proteins controlling IRES-dependent translation initiation are regulated by their subcellular localization.
Lewis
S M
SM
Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Holcik
M
M
D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D014176:Protein Biosynthesis / Q000187:drug effects / Q000502:physiology; D012333:RNA, Messenger / Q000502:physiology*; D012270:Ribosomes / Q000378:metabolism*; D015534:Trans-Activators / Q000502:physiology*; D014750:Vincristine / Q000494:pharmacology
D012333:RNA, Messenger; D015534:Trans-Activators; D014750:Vincristine