Antioxidant status and circulating lipids are altered in human gestational diabetes and macrosomia.
Fetuses from mothers with gestational diabetes are at increased risk of developing neonatal macrosomia and oxidative stress. We investigated the modulation of antioxidant status and circulating lipids in gestational diabetic mothers and their macrosomic babies and in healthy age-matched pregnant women and their newborns. The serum antioxidant status was assessed by employing anti-radical resistance kit (KRL; Kirial International SA, Couternon, France) and determining levels of vitamin A, C, and E and the activity of superoxide dismutase (SOD). Circulating serum lipids were quantified, and lipid peroxidation was measured as the concentrations of serum thiobarbituric acid-reactive substances (TBARS). As compared with non-diabetic mothers, gestational diabetic women exhibited decreased levels of vitamin E and enhanced concentrations of vitamin C without any changes in vitamin A. Vitamin A and C levels did not change in macrosomic babies except vitamin E whose levels were lower in these infants than in the newborns of non-diabetic mothers. Gestational diabetes mellitus (GDM) and macrosomia were also associated with impaired SOD activities and enhanced TBARS levels. Globally, total serum antioxidant defense status in diabetic mothers and their macrosomic babies was diminished as compared with control subjects. Triglyceride and cholesterol concentrations did not differ significantly between gestational diabetic and control mothers; however, macrosomia was associated with enhanced plasma cholesterol and triglyceride levels. These results suggest that human GDM and macrosomia are associated with downregulation of antioxidant status, and macrosomic infants also exhibit altered lipid metabolism.
Grissa
Oussama
O
Department of Physiology and Functional Explorations, Farhat Hached University Hospital, 4000 Sousse, Tunisia.
Atègbo
Jean-Marc
JM
Yessoufou
Akadiri
A
Tabka
Zouhair
Z
Miled
Abdelhedi
A
Jerbi
Mehdi
M
Dramane
Karim L
KL
Moutairou
Kabirou
K
Prost
Josiane
J
Hichami
Aziz
A
Khan
Naim Akhtar
NA
D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D001205:Ascorbic Acid / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood / Q000378:metabolism*; D005260:Female; D005320:Fetal Macrosomia / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood*; D011247:Pregnancy; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014801:Vitamin A / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D014801:Vitamin A; D014810:Vitamin E; D002784:Cholesterol; D013482:Superoxide Dismutase; D001205:Ascorbic Acid