Tensins: a new switch in cell migration.
Epidermal Growth Factor (EGF) is an important regulator of normal epithelial and carcinoma cell migration. The mechanism by which EGF induces cell migration is not fully understood. A recent report in Nature Cell Biology (Katz et al., 2007) demonstrates that EGF regulates migration through a switch in the expression of two tensin isoforms, weakening the association of beta1 integrin with the actin cytoskeleton in focal adhesions.
Mouneimne
Ghassan
G
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. joan_brugge@hms.harvard.edu
Brugge
Joan S
JS
D000199:Actins / Q000378:metabolism; D001943:Breast Neoplasms / Q000473:pathology; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D022001:Focal Adhesions / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D019012:Integrin beta1 / Q000378:metabolism; D008840:Microfilament Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D000070876:Tensins
D000199:Actins; D015815:Cell Adhesion Molecules; D004815:Epidermal Growth Factor; D019012:Integrin beta1; D008840:Microfilament Proteins; D020033:Protein Isoforms; D018719:Erb-b2 Receptor Tyrosine Kinases; D000070876:Tensins