title: Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation.
abstract: A novel potent NMDA-NR2B selective antagonist without the reactive metabolites formation issue was identified. Through this study, a close correlation between reactive metabolites formation and calculated HOMO energies of parent compounds was found.
authors.affiliation: Discovery Chemistry, Pfizer Global Research & Development, Nagoya Laboratories, 5-2 Taketoyo, Aichi 470-2393, Japan. makoto.kawai@pfizer.com
authors.forename: Makoto
authors.initials: M
authors.lastname: Kawai
authors.forename: Isao
authors.initials: I
authors.lastname: Sakurada
authors.forename: Asato
authors.initials: A
authors.lastname: Morita
authors.forename: Yuko
authors.initials: Y
authors.lastname: Iwamuro
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ando
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Omura
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sakakibara
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Masuda
authors.forename: Hiroki
authors.initials: H
authors.lastname: Koike
authors.forename: Teruki
authors.initials: T
authors.lastname: Honma
authors.forename: Kazunari
authors.initials: K
authors.lastname: Hattori
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Takashima
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Mizuno
authors.forename: Mayumi
authors.initials: M
authors.lastname: Mizutani
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kawamura
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D019800:Phenol / Q000737:chemistry; D010636:Phenols / Q000737:chemistry; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; C121001:NR2B NMDA receptor; D010636:Phenols; D016194:Receptors, N-Methyl-D-Aspartate; D019800:Phenol; D005978:Glutathione