title: Variation in complement factor 3 is associated with risk of age-related macular degeneration.
abstract: The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample.
authors.affiliation: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
authors.forename: Julian B
authors.initials: JB
authors.lastname: Maller
authors.forename: Jesen A
authors.initials: JA
authors.lastname: Fagerness
authors.forename: Robyn C
authors.initials: RC
authors.lastname: Reynolds
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Neale
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Daly
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Seddon
mesh_terms: D016022:Case-Control Studies; D003176:Complement C3 / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D012307:Risk Factors
chemical_list: D003176:Complement C3