Genetic polymorphisms of macrophage-mediators in Guillain-Barré syndrome.
Macrophages infiltrate peripheral nerves and may contribute to neural damage in the Guillain-Barré syndrome (GBS). We determined whether single nucleotide polymorphisms (SNP) in genes encoding macrophage-mediators are related to the susceptibility and severity of GBS. The frequencies of SNP in the TNFA, MMP9, IL10, and NOS2a genes did not differ between 263 GBS patients and 210 healthy subjects. The MMP9 C(-1562)T and TNFA C(-863)A SNP were associated with severe weakness and poor outcome, indicating that these SNP may be one of the factors predisposing to a severe form of GBS.
Geleijns
Karin
K
Department of Neurology, Erasmus MC, 's-Gravendijkwal 230, Rotterdam, The Netherlands. c.geleijns@erasmusmc.nl
Emonts
Marieke
M
Laman
Jon D
JD
van Rijs
Wouter
W
van Doorn
Pieter A
PA
Hermans
Peter W M
PW
Jacobs
Bart C
BC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D016207:Cytokines / Q000235:genetics* / Q000276:immunology; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D020275:Guillain-Barre Syndrome / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology*; D016753:Interleukin-10 / Q000235:genetics; D008264:Macrophages / Q000276:immunology*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D008875:Middle Aged; D052247:Nitric Oxide Synthase Type II / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D016207:Cytokines; D005819:Genetic Markers; C508609:IL10 protein, human; D018836:Inflammation Mediators; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; D020780:Matrix Metalloproteinase 9