title: Outcomes in patients treated by laparoscopic resection of rectal carcinoma after neoadjuvant therapy for rectal cancer.
abstract: OBJECTIVE
  We analyzed the effect of neoadjuvant chemo radiation on feasibility and outcomes in rectal cancer patients undergoing laparoscopic resection of the rectum.
  
  
  METHODS
  This was a retrospective analysis of a consecutive series of laparoscopic resections for rectal cancer from 1998 to 2004 (N=60).
  
  
  RESULTS
  Eight patients received preoperative chemoradiation therapy (neoadjuvant group) for rectal cancer and 52 patients did not (primary surgical group). The conversion rate was higher in the neoadjuvant group, but this did not reach statistical significance (3/8, 37% in the neoadjuvant group vs. 7/52, 13% in the primary surgical group, P=0.12). Operative time was longer in the neoadjuvant group (170+/-60 vs 228+/-70 min, P=0.03). Complication rates (3/52, 5.7% in the primary surgical vs. 0% in the neoadjuvant group, P=1.0), and a median number of resected lymph nodes (14.5 in the primary surgical vs. 16.0 in the neoadjuvant group, P=0.81) were similar between groups.
  
  
  CONCLUSIONS
  Laparoscopic resection of rectal cancer in patients after preoperative chemoradiation treatment seems to be associated with a higher conversion rate and a longer duration of surgery. No change in mortality and morbidity was detected. We encourage further investigation of laparoscopic rectal surgery for treatment of rectal cancer.
authors.affiliation: Department of Surgery, Abington Memorial Hospital, Abington, Pennsylvania 19001, USA. mrezvani@amh.org
authors.forename: Masoud
authors.initials: M
authors.lastname: Rezvani
authors.forename: Jan
authors.initials: J
authors.lastname: Franko
authors.forename: Steven A
authors.initials: SA
authors.lastname: Fassler
authors.forename: Steven G
authors.initials: SG
authors.lastname: Harper
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Nejman
authors.forename: D Mark
authors.initials: DM
authors.lastname: Zebley
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D020360:Neoadjuvant Therapy; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome