Ethambutol neuroretinopathy.
OBJECTIVE
To describe the clinical features of ethambutol neuroretinopathy.


METHODS
Case report and meta-analysis of the literature.


METHODS
A patient with clinical and electrophysiological findings suggestive of ethambutol neuroretinopathy.


METHODS
Electroretinogram, electro-oculogram and visual fields.


METHODS
Clinical and electrophysiological findings.


RESULTS
101 cases were reviewed, retinal findings include retinal pigment epithelial changes, macular edema, flame-shaped hemorrhages. Electroretinogram findings include decreased amplitude and abnormal wave pattern in full field ERG, multifocal or pattern ERG and electro-oculogram findings include abnormal Arden ratio.


CONCLUSIONS
Clinical, electrophysiological and in vitro studies support the toxic effect of ethambutol on the retina. Therefore ethambutol ocular toxicity may be a neuroretinopathy.
Vistamehr
Setareh
S
Yale University School of Medicine, Department of Ophthalmology and Visual Sciences, New Haven, CT 06520-8061, USA.
Walsh
Thomas J
TJ
Adelman
Ron A
RA
D000328:Adult; D000818:Animals; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004585:Electrooculography; D004596:Electroretinography; D004977:Ethambutol / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008482:Mediastinum; D012164:Retinal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D014376:Tuberculosis / Q000188:drug therapy; D014794:Visual Fields
D000995:Antitubercular Agents; D004977:Ethambutol