title: Gut overgrowth of vancomycin-resistant enterococci (VRE) results in linezolid-resistant mutation in a child with severe congenital neutropenia: a case report.
abstract: A child with severe congenital neutropenia was monitored with microbiologic surveillance cultures for 3 years. He had recurrent bacterial infections and carriage of vancomycin-resistant enterococci. Resistance to linezolid emerged in the colonizing vancomycin-resistant enterococci after each course of this antibiotic when enterococci were present in overgrowth in the gut before treatment. The child was successfully treated for his congenital neutropenia by unrelated donor stem cell transplantation.
authors.affiliation: Department of Haematology and Oncology, Royal Liverpool Children's NHS Trust, Alder Hey, Liverpool.
authors.forename: Nitin
authors.initials: N
authors.lastname: Verma
authors.forename: Ray W
authors.initials: RW
authors.lastname: Clarke
authors.forename: Paula H B
authors.initials: PH
authors.lastname: Bolton-Maggs
authors.forename: Hendrik K F
authors.initials: HK
authors.lastname: van Saene
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D016983:Enterococcus / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D000069349:Linezolid; D009154:Mutation; D009503:Neutropenia / Q000150:complications* / Q000601:surgery; D023303:Oxazolidinones / Q000494:pharmacology / Q000627:therapeutic use*; D011500:Protein Synthesis Inhibitors; D033581:Stem Cell Transplantation; D013290:Streptococcal Infections / Q000150:complications / Q000188:drug therapy*; D014640:Vancomycin / Q000494:pharmacology; D020713:Vancomycin Resistance
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D011500:Protein Synthesis Inhibitors; D014640:Vancomycin; D000069349:Linezolid