title: Architectonic distribution of the serotonin transporter within the orbitofrontal cortex of the vervet monkey.
abstract: To elucidate the organization of the serotoninergic innervation within the orbitofrontal cortex (OFC), serotonin transporter (SERT) density was quantified by autoradiography using [(3)H]cyanoimipramine binding. In six adult vervet monkeys, 15 architectonic areas were delineated according to cytoarchitectonic (Nissl), myeloarchitectonic (Gallyas) and chemoarchitectonic (acetylcholinesterase) criteria to assess SERT distribution at two levels of organization: cortical area and cortical type. For cortical type, the 15 areas were evenly divided into three different categories primarily based upon the degree of granularization of layer IV: agranular, dysgranular, and granular. Within agranular and dysgranular, but not granular cortical types, SERT density was area-specific and progressively decreased in a medial to lateral gradient. Across cortical types, SERT density decreased in a caudal to rostral gradient: agranular>dysgranular>granular. A similar caudal to rostral gradient was seen when serotonin content was measured (using high performance liquid chromatography) in areas representative of each cortical type. Collectively, these results suggest that the serotoninergic innervation is organized according to both cortical type and area, and is thus structured to differentially modulate information processing within the OFC.
authors.affiliation: Department of Molecular and Medical Pharmacology, 23-120 CHS, David Geffen School of Medicine at the University of California at Los Angeles, Box 951735, Los Angeles, CA 90095-1735, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Way
authors.forename: G
authors.initials: G
authors.lastname: Laćan
authors.forename: L A
authors.initials: LA
authors.lastname: Fairbanks
authors.forename: W P
authors.initials: WP
authors.lastname: Melega
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001345:Autoradiography / Q000379:methods; D001931:Brain Mapping; D002522:Chlorocebus aethiops / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D007099:Imipramine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D008297:Male; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000493:pharmacokinetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D014316:Tritium / Q000493:pharmacokinetics
chemical_list: D012702:Serotonin Antagonists; D050486:Serotonin Plasma Membrane Transport Proteins; C024316:cianopramine; D014316:Tritium; D012701:Serotonin; D000110:Acetylcholinesterase; D007099:Imipramine