title: Optimization of the high-shear wet granulation wetting process using fuzzy logic modeling.
abstract: A fuzzy model has been developed for the optimization of high-shear wet granulation wetting on a plant scale depending on the characteristics of pharmaceutical active substance particles. The model optimized on the basis of experimental data involves a set of rules obtained from expert knowledge and full-scale process data. The skewness coefficient of particle size distribution and the tapped density of the granulated mixture were chosen as the model input variables. The output of the fuzzy ruled system is the optimal quantity of wetting liquid. In comparison to manufacturing practice, a very strong sensitivity of the optimal quantity of the added wetting liquid to the size and shape of the active substance particles has been identified by fuzzy modeling.
authors.affiliation: Department of Organic Technology, Institute of Chemical Technology Prague, Prague, Czech Republic.
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Belohlav
authors.forename: Lucie
authors.initials: L
authors.lastname: Brenkova
authors.forename: Jana
authors.initials: J
authors.lastname: Kalcikova
authors.forename: Jiri
authors.initials: J
authors.lastname: Hanika
authors.forename: Petr
authors.initials: P
authors.lastname: Durdil
authors.forename: Vaclav
authors.initials: V
authors.lastname: Tomasek
authors.forename: Marta
authors.initials: M
authors.lastname: Palatova
mesh_terms: D002626:Chemistry, Pharmaceutical; D005079:Excipients / Q000737:chemistry*; D017143:Fuzzy Logic; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*; D014867:Water / Q000737:chemistry; D017155:Wettability
chemical_list: D005079:Excipients; D004364:Pharmaceutical Preparations; D014867:Water