title: The possible role of hyperhomocysteinemia on IVF outcome.
abstract: OBJECTIVE
  To evaluate the effect of the hyperhomocysteinemia on pregnancy rate, implantation rate and abortion rate after IVF.
  
  
  METHODS
  Data from a total of 48 infertile couples with hyperhomocysteinemia were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes recovery was performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups that received or did not receive therapy (group A and B respectively) to normalize homocysteine plasma level.
  
  
  RESULTS
  Pregnancy rate, implantation rate and abortion rate varied significantly (p<or=0.05) between the two groups. The number and quality of embryos transferred did not differ between the groups.
  
  
  CONCLUSIONS
  The results suggest that hyperhomocysteinemia could affect IVF outcome.
authors.affiliation: Obstetric and Gynecology, Policlinico Umberto, La Sapienza University of Rome, Viale Regina Elena, Rome, Italy. arypac@aliceposta.it
authors.forename: Arianna
authors.initials: A
authors.lastname: Pacchiarotti
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Mohamed
authors.forename: Giulietta
authors.initials: G
authors.lastname: Micara
authors.forename: Antonella
authors.initials: A
authors.lastname: Linari
authors.forename: Daniela
authors.initials: D
authors.lastname: Tranquilli
authors.forename: Salomè B
authors.initials: SB
authors.lastname: Espinola
authors.forename: Cesare
authors.initials: C
authors.lastname: Aragona
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D010064:Embryo Implantation; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate