title: Phase II study of paclitaxel and irinotecan chemotherapy in patients with advanced nonsmall cell lung cancer.
abstract: OBJECTIVE
  We conducted a phase II study of combination chemotherapy with paclitaxel (Pac) and irinotrecan (CPT) to determine the qualitative and quantitative toxicities and efficacy of the combination against advanced nonsmall cell lung cancer (NSCLC).
  
  
  METHODS
  Patients with stage IIIB or IV NSCLC were treated with CPT at 60 mg/m and Pac at 160 mg/m2 every 2 weeks.
  
  
  RESULTS
  Between May 2002 and July 2004, 39 of registered 46 patients received 4 to 6 cycles of chemotherapy, and 7 patients discontinued treatment because of disease progression in 5 patients and grade 2 pneumonitis in 2 patients. Grade 3 anemia, leukopenia, neutropenia, and elevation of bilirubin occurred in 4.0%, 0.5%, 1.0%, and 0.5%, respectively. Twenty-one patients responded, and the overall response rate was 45.6%. The median survival time was 355 days and the 1-year survival rate was 47.8%.
  
  
  CONCLUSIONS
  Pac plus CPT was efficacious and safe in NSCLC.
authors.affiliation: Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan. foshita@kcch.jp
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Oshita
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Saito
authors.forename: Kouzo
authors.initials: K
authors.lastname: Yamada
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Noda
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D020714:Maximum Tolerated Dose; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D011379:Prognosis; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000077146:Irinotecan; D017239:Paclitaxel; D002166:Camptothecin