Role of genetic polymorphisms in ACE and TNF-alpha gene in sarcoidosis: a meta-analysis.
A great number of association studies have been performed to identify the genes involved in the etiology and prognosis of sarcoidosis. We performed a systematic review of case-control studies through the PubMed database and evaluated them for a possible inclusion into a meta-analysis in order to assess whether the reported genetic polymorphisms are the risk factors of sarcoidosis. Case-control studies with clear diagnostic criteria and interventions were included. Only investigations of a single polymorphism/gene involvement in sarcoidosis reported more than five times were selected. Aggregating data from 12 studies on ID/ACE polymorphisms, the odds ratio (OR) for sarcoidosis, if the polymorphism was considered under the dominant genetic model, was not significantly increased: 1.19 (95% CI 0.98-1.43); OR under the recessive model was 1.20 (95% CI 0.98-1.46). In seven case-control studies on -308/TNF-alpha polymorphism, the OR for sarcoidosis if the polymorphism considered under the dominant genetic model was significantly increased at 1.47 (95% CI 1.03-2.08); the OR under the recessive model was 1.39 (95% CI 0.67-2.90). In conclusion, the results showed that the TNF-alpha genotype could be a significant risk factor for sarcoidosis, whereas the risk of sarcoidosis due to the ACE genotype was not substantially elevated.
Medica
Igor
I
Division of Medical Genetics, Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Slovenia.
Kastrin
Andrej
A
Division of Medical Genetics, Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Slovenia.
Maver
Ales
A
Division of Medical Genetics, Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Slovenia.
Peterlin
Borut
B
Division of Medical Genetics, Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Slovenia. borut.peterlin@guest.arnes.si.
D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012507:Sarcoidosis / Q000208:ethnology / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha; D007703:Peptidyl-Dipeptidase A