title: [Generalized congenital lipodystrophy: correlation with leptin and other biochemical parameters].
abstract: OBJECTIVE
  To correlate serum leptin and insulin levels, and the glucosic profile of 21 patients shared in diabetics and non diabetics with Congenital Generalized Lipodystrophy (CGL).
  
  
  METHODS
  In a prospective study, were dosed serum leptin level with radioimmunoassay technique, fasting plasma glucose through of the glucoseoxidase-peroxidase reaction, the hemoglobin glycate using the technique microchromatography for ionic exchange resin and insulin through immunoassay system. The fructosamine concentration serum was determinated for reduction nitroblue tetrazolium method. The Student's test was used to compare results between the groups and the correlation "r" coefficient to analise the relation among the several variants studied, with significant level of 5% (p < 0.05). All the statistical procedures were performed using the Excel by Microsoft and the Statistic program for Windows by StatSoft, Inc. version 5.1 edition 97.
  
  
  RESULTS
  Leptin decreased on the most patients, showing no statistically significant difference between the groups. Also there wasn't difference statistically significant (p = 0.9542) of the insulin's value between diabetics and non diabetics.
  
  
  CONCLUSIONS
  The hyperinsulinism and the hypoleptinemia occurred independently of diabetes in the CGL's patients and this can be due to the natural history of disease, in which the raise insulin levels precede the initial diabetes mellitus and the low leptin levels were related to the lipoatrophy.
authors.affiliation: Departamento de Análises Clínicas e Toxicológicas do Centro de Ciências da Saúde na Universidade Federal do Rio Grande do Norte (UFRN). goretti@ufrnet.br
authors.forename: Maria Goretti do Nascimento
authors.initials: MG
authors.lastname: Santos
authors.forename: Tereza Maria Dantas
authors.initials: TM
authors.lastname: de Medeiros
authors.forename: Maria de Fátima Paiva
authors.initials: Mde F
authors.lastname: Baracho
authors.forename: José
authors.initials: J
authors.lastname: Brandão-Neto
authors.forename: Aline Maria Cavalcante
authors.initials: AM
authors.lastname: Gurgel
authors.forename: Ana Séphora Costa
authors.initials: AS
authors.lastname: da Silva
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D003923:Diabetes Mellitus, Lipoatrophic / Q000097:blood*; D005260:Female; D019270:Fructosamine / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D052497:Lipodystrophy, Congenital Generalized / Q000097:blood*; D008297:Male; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D020738:Leptin