title: BIOTIN DEFICIENCY AND OTHER CHANGES IN RATS GIVEN SULFANILYLGUANIDINE OR SUCCINYL SULFATHIAZOLE IN PURIFIED DIETS.
abstract: The following pathological changes have been observed in rats given sulfaguanidine or sulfasuxidine in purified diets. 1. A granulocytopenia, leukopenia, hypocellularity of bone marrow and, occasionally, an anemia. 2. Hyalinization, necrosis and calcification of voluntary muscle. 3. Hyaline sclerosis and calcification of blood vessels. 4. A dermatitis which can be prevented or successfully treated with crystalline biotin. We have also observed necrosis of heart muscle, hemorrhage into various organs and subcutaneous tissues, and liver damage.
authors.forename: F S
authors.initials: FS
authors.lastname: Daft
authors.forename: L L
authors.initials: LL
authors.lastname: Ashburn
authors.forename: W H
authors.initials: WH
authors.lastname: Sebrell