title: Study on hemostatic mechanism of fully soluble hemostatic fiber.
abstract: Fully soluble hemostatic fiber (FHF) is made from cotton yarn through a series of chemical reactions with NaOH and chloroacetic acid. The major component of FHF is carboxymethylcellulose. FHF is a kind of biodegradation macromolecule material that can disassociate into a low-molecular-weight compound or a simple substance by hydrolytic and enzymatic courses. The purpose of the present study is to investigate the hemostatic mechanism of FHF. The study indicated that FHF can stop bleeding by physical, chemical and physiological routes. In the physical route, expansion of carboxymethylcellulose in FHF stops bleeding by forming a mechanical clog after contacting with the blood. In the chemical route, the platelets can quickly aggregate around FHF and stimulate releasing and disaggregating reactions, after contacting with the rough surface of FHF, producing thrombus and hemostasis. In the physiological route, gluey particles with negative charges can activate intrinsic coagulation systems by activating the blood coagulation factor XII after FHF dissolution.
authors.affiliation: College of Pharmacy, Dalian Medical University, Liaoning, Dalian, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Wang
authors.forename: Changyuan
authors.initials: C
authors.lastname: Wang
authors.forename: Jihong
authors.initials: J
authors.lastname: Yao
authors.forename: Kexin
authors.initials: K
authors.lastname: Liu
mesh_terms: D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology*; D032561:Cotton Fiber; D006470:Hemorrhage / Q000188:drug therapy / Q000517:prevention & control*; D006487:Hemostasis / Q000187:drug effects*; D006490:Hemostatics / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D006490:Hemostatics; D002266:Carboxymethylcellulose Sodium