title: Enterovirus 71 meningoencephalitis during chemotherapy in a child with metastatic osteosarcoma.
abstract: Enterovirus meningoencephalitis is rare but can be severe. Very few cases of these infections have been reported in pediatric oncology. We report the case of a 10-year-old boy with tibial osteosarcoma and lung metastases who developed enterovirus 71 meningoencephalitis during aplasia. Clinical features comprised fever, hypotension, vesicular rash, generalized seizures, and altered consciousness. Diagnosis was confirmed by polymerase chain reaction on samples of cerebrospinal fluid and skin vesicles. The patient received treatment with intravenous immunoglobulins with an excellent outcome with no cutaneous or neurologic sequelae. Immunoglobulin therapy could be considered in cases of invasive enteroviral infection with such severity in pediatric oncology.
authors.affiliation: Pediatric Oncology Department, Hôpital Necker Enfants Malades, APHP, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Frange
authors.forename: Jean
authors.initials: J
authors.lastname: Michon
authors.forename: Isabelle
authors.initials: I
authors.lastname: Fromantin
authors.forename: Nathalie
authors.initials: N
authors.lastname: Franck
authors.forename: Eva
authors.initials: E
authors.lastname: Safar
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Escande
authors.forename: Isabelle
authors.initials: I
authors.lastname: Desguerre
authors.forename: Daniel
authors.initials: D
authors.lastname: Orbach
mesh_terms: D001859:Bone Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D002648:Child; D004770:Enterovirus / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis* / Q000188:drug therapy* / Q000821:virology; D012516:Osteosarcoma / Q000150:complications* / Q000188:drug therapy / Q000556:secondary; D016896:Treatment Outcome
chemical_list: D007136:Immunoglobulins