Plasma level of cardiotrophin-1 as a prognostic predictor in patients with chronic heart failure.
BACKGROUND
Cardiotrophin-1 (CT-1) is a member of the interleukin (IL-6) family of cytokines and is increased in patients with chronic heart failure (CHF).


OBJECTIVE
To evaluate the prognostic role of CT-1 in patients with CHF.


RESULTS
We measured the plasma levels of CT-1, brain natriuretic peptide (BNP), and IL-6 in 125 patients with CHF. Patients were monitored for a mean follow-up period of 2.9 years. Plasma levels of CT-1 increased with severity of CHF. There was a significant negative correlation between plasma CT-1 and left ventricular ejection fraction. There was a significant correlation between plasma CT-1 and log IL-6. During the follow-up period, 37 patients died. High plasma levels of CT-1, BNP, and IL-6 were independent predictors of mortality on stepwise multivariate analysis. The hazard ratio for mortality in patients with plasma BNP>170 pg/mL and CT-1>658 fmol/mL was 2.48 (95% confidence interval, 1.217-5.060) compared to those with plasma BNP>170 pg/mL and CT-1<658 fmol/mL (p=0.0124).


CONCLUSIONS
These findings indicate that plasma CT-1 measurement provides additional prognostic information and that combined levels of CT-1 and BNP are more accurate at predicting mortality in patients with CHF than either marker alone.
Tsutamoto
Takayoshi
T
Department of Cardiovascular Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, 520-2192, Japan. tutamoto@belle.shiga-med.ac.jp
Asai
Shigeru
S
Tanaka
Toshinari
T
Sakai
Hiroshi
H
Nishiyama
Keizo
K
Fujii
Masanori
M
Yamamoto
Takashi
T
Ohnishi
Masato
M
Wada
Atsuyuki
A
Saito
Yoshihiko
Y
Horie
Minoru
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D015850:Interleukin-6; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011379:Prognosis; D011446:Prospective Studies; D012333:RNA, Messenger; D013318:Stroke Volume
D015415:Biomarkers; D016207:Cytokines; D015850:Interleukin-6; D012333:RNA, Messenger; D020097:Natriuretic Peptide, Brain; C092073:cardiotrophin 1