title: Assessment of left ventricular dyssynchrony with real-time 3-dimensional echocardiography: comparison with Doppler tissue imaging.
abstract: We studied the usefulness and reproducibility of real-time 3-dimensional (3D) echocardiography (RT3DE) for evaluating left ventricular (LV) dyssynchrony, and compared its results with Doppler tissue image (DTI) indices. Full-volume RT3DE data sets and 2-dimensional DTI from apical window were obtained in 122 participants. Using fast 3D border detection software, time to minimum systolic volume (Tmsv) was semiautomatically calculated in each region from a 17-segment model. Several dyssynchrony indices were then calculated: Tmsv-16SD, the SD of Tmsv in 16 of 17 segments, excluding the apical cap; Tmsv-12SD, the SD of Tmsv of 6 basal and 6 middle segments; and Tmsv-6SD, the SD of Tmsv of 6 basal segments. These dyssynchrony indices of RT3DE were then compared with two dyssynchrony indices measured by DTI: time to peak systolic velocity (TTPV)-12SD, the SD of time to peak systolic velocity of 12 LV segments; and time to cross over point of temporal axis (TTCO)-12SD, the SD of time to crossover point of temporal axis. RT3DE data was quantitatively analyzed in 117 of 122 patients. Tmsv-16SD (35 +/- 34 milliseconds) was significantly longer compared with Tmsv-12SD (27 +/- 30 milliseconds, P < .001) or Tmsv-6SD (23 +/- 28 milliseconds, P < .001). Tmsv-16SD increased significantly with the severity of LV systolic dysfunction. Fair correlation was noted among TTPV-12SD, TTCO-12SD, and Tmsv-16SD (r = 0.71, r = 0.73) and between Tmsv-16SD and LV ejection fraction (r = 0.80). Concordance rate between TTPV-12SD and Tmsv-16SD for detecting LV dyssynchrony was 79%. The corresponding value between TTCO-12SD and Tmsv-16SD was 80%. In conclusion, Tmsv-16SD correlated well with DTI-derived LV dyssynchrony indices. In addition to LV remodeling, fast border detection RT3DE provides useful parameters for evaluating LV dyssynchrony.
authors.affiliation: Department of Cardiology and Internal Medicine, Tane General Hospital, Osaka, Japan. masaaki_takeuchi@hotmail.com
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Avrum
authors.initials: A
authors.lastname: Jacobs
authors.forename: Lissa
authors.initials: L
authors.lastname: Sugeng
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nishikage
authors.forename: Hiromi
authors.initials: H
authors.lastname: Nakai
authors.forename: Lynn
authors.initials: L
authors.lastname: Weinert
authors.forename: Ivan S
authors.initials: IS
authors.lastname: Salgo
authors.forename: Roberto M
authors.initials: RM
authors.lastname: Lang
mesh_terms: D018618:Echocardiography, Doppler, Color / Q000379:methods*; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*