Prevalence and risk factors of peripheral arterial disease in diabetic patients over 50 years old in China.
OBJECTIVE
To investigate the prevalence of peripheral arterial disease (PAD) in China type 2 diabetic patients and to demonstrate the relationships between putative risk factors and PAD.


METHODS
In total 1,397 type 2 diabetic patients aged 50 years and older were enrolled and determined ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in 15 Class III Grade A hospitals in 7 major cities of China.


RESULTS
Mean patient age was 63.7 +/- 8.2 years and mean duration of diabetes mellitus was 9.39 +/- 7.4 years. Two hundreds and seventy-two (19.47%) patients were diagnosed as PAD by ABI < 0.9, 122 (18.37%) in male and 150 (20.46%) in female. PAD patients had a significantly longer duration of diabetes mellitus, higher hemoglobin A1c, and a significantly lower mean body mass index than non-PAD ones. Aging, smoking, and systolic blood pressure were found to be positively related with the prevalence of PAD. In terms of lipid profiles, no variable was found to relate with PAD. Notably, baPWV showed as the same significant guiding index for PAD, almost matched with ABI.


CONCLUSIONS
PAD is a common complication in China type 2 diabetic patients. Therefore, PAD screening and treatment should be emphasized for diabetic patients with high risk factors.
Guan
Heng
H
Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730. guanheng3@hotmail.com
Li
Yong-Jun
YJ
Xu
Zhang-Rong
ZR
Li
Guang-Wei
GW
Guo
Xiao-Hui
XH
Liu
Zhi-Min
ZM
Zou
Da-Jin
DJ
Xing
Hui-Li
HL
Liu
Wei
W
Sheng
Zheng-Yan
ZY
Tian
Hao-Ming
HM
Zhu
Da-Long
DL
Yu
De-Min
DM
Zhuang
Wei-Te
WT
Chen
Lu-Lu
LL
Weng
Jian-Ping
JP
D000368:Aged; D002681:China / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D014505:Urban Population / Q000706:statistics & numerical data