title: Cardiovascular events and re-stenosis following administration of G-CSF in acute myocardial infarction: systematic review and meta-analysis.
abstract: BACKGROUND
  Because of the recently published results of the MAGIC study there is confusion as to whether administration of granulocyte-colony stimulating factor (G-CSF) after acute myocardial infarction (MI) should be regarded as a potentially harmful treatment. This meta-analysis of appropriate clinical studies is intended to show the impact of G-CSF given after MI on aggravated incidence of coronary re-stenosis or progression of coronary lesions.
  
  
  METHODS
  We used a fixed effects model based on the Mantel-Haenszel method to combine results from the different trials. These studies provided the basis for the current analysis comprising 106 patients of whom 62 were subjected to G-CSF treatment.
  
  
  RESULTS
  Minimum lumen diameter (MLD) measured immediately after percutaneous coronary intervention (PCI) was similar in both groups with a diameter stenosis of 12.3% (SD 9.5%) in the G-CSF group and 10.3% (8.5%) in the control group (p = 0.32). At follow-up, both MLD and percentage stenosis were not different between G-CSF-treated and control patients. Subsequently, averaged late lumen loss revealed similar results and no differences between groups (p = 0.11), and neither stent thrombosis nor re-infarction in either group.
  
  
  CONCLUSIONS
  The current meta-analysis of clinical reports fails to justify an elevated risk for coronary re-stenosis after PCI in acute MI or adverse events following G-CSF in the setting of MI when used after state of the art treatment in carefully conducted clinical protocols.
authors.affiliation: Department of Medicine, Divisions of Cardiology at the University Hospital Rostock, Rostock School of Medicine, Rostock, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Ince
authors.forename: M
authors.initials: M
authors.lastname: Valgimigli
authors.forename: M
authors.initials: M
authors.lastname: Petzsch
authors.forename: J Suarez
authors.initials: JS
authors.lastname: de Lezo
authors.forename: F
authors.initials: F
authors.lastname: Kuethe
authors.forename: S
authors.initials: S
authors.lastname: Dunkelmann
authors.forename: G
authors.initials: G
authors.lastname: Biondi-Zoccai
authors.forename: C A
authors.initials: CA
authors.lastname: Nienaber
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods*; D006332:Cardiomegaly / Q000209:etiology* / Q000473:pathology; D017023:Coronary Angiography / Q000379:methods; D023903:Coronary Restenosis / Q000209:etiology*; D003331:Coronary Vessels / Q000187:drug effects / Q000473:pathology*; D003627:Data Interpretation, Statistical; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor