title: Comparison between full-mouth scaling and root planing and quadrant-wise basic therapy of aggressive periodontitis: 6-month clinical results.
abstract: BACKGROUND
  The aim of this study was to test the hypothesis that there are no differences in clinical parameters in generalized aggressive periodontitis patients after full-mouth scaling and root planing (FRP) or quadrant-wise basic periodontal therapy (BPT) when combined with an antibiotic regimen.
  
  
  METHODS
  Patients were allocated randomly to BPT (N = 15; mean age: 29.5 +/- 5.7 years) or FRP (N = 15; mean age: 28.4 +/- 5.7 years). All subjects received oral hygiene instructions including the use of a 0.12% chlorhexidine mouthrinse solution twice a day for 2 months. Patients also received amoxicillin, 500 mg, and metronidazole, 250 mg, three times a day for 7 days. Probing depth (PD), clinical attachment level, visible plaque, and bleeding on probing were recorded at baseline and at 2, 4, and 6 months post-therapy. Statistically significant changes within and between groups were determined using the general linear model repeated measures procedure.
  
  
  RESULTS
  Both groups showed a significant improvement in all clinical parameters post-therapy, which was particularly evident at 2 months in the sites that had been deepest at baseline. For instance, the mean PD at sites with mean PD > or =7 mm at baseline had decreased 3.9 mm in the BPT group and 3.6 mm in the FRP group. At 6 months, the percentage of sites with PD > or =7 mm decreased from 13.2% +/- 3.2% to 0% in the BPT group and from 13.3% +/- 3.5% to 0.2% +/- 0.1% in the FRP group. No statistically significant differences were observed between groups for most clinical parameters.
  
  
  CONCLUSIONS
  Within the limits of the present investigation, FRP and BPT caused comparable clinical effects in aggressive periodontitis patients when an adjunctive combined antibiotic regimen was included.
authors.affiliation: Graduate Periodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Rafael M
authors.initials: RM
authors.lastname: Moreira
authors.forename: Eduardo J
authors.initials: EJ
authors.lastname: Feres-Filho
mesh_terms: D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D002710:Chlorhexidine / Q000627:therapeutic use; D012534:Dental Scaling / Q000009:adverse effects / Q000379:methods*; D004338:Drug Combinations; D005157:Facial Pain / Q000209:etiology; D005334:Fever / Q000209:etiology; D006560:Herpes Labialis / Q000209:etiology; D006801:Humans; D016014:Linear Models; D008795:Metronidazole / Q000008:administration & dosage; D009067:Mouthwashes / Q000627:therapeutic use; D010512:Periodontal Index; D010518:Periodontitis / Q000628:therapy*
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D009067:Mouthwashes; D008795:Metronidazole; D000658:Amoxicillin; D002710:Chlorhexidine