title: Effects of an integrated yoga program in modulating psychological stress and radiation-induced genotoxic stress in breast cancer patients undergoing radiotherapy.
abstract: Effects of an integrated yoga program in modulating perceived stress levels, anxiety, as well as depression levels and radiation-induced DNA damage were studied in 68 breast cancer patients undergoing radiotherapy. Two psychological questionnaires--Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS)--and DNA damage assay were used in the study. There was a significant decrease in the HADS scores in the yoga intervention group, whereas the control group displayed an increase in these scores. Mean PSS was decreased in the yoga group, whereas the control group did not show any change pre- and postradiotherapy. Radiation-induced DNA damage was significantly elevated in both the yoga and control groups after radiotherapy, but the postradiotherapy DNA damage in the yoga group was slightly less when compared to the control group. An integrated approach of yoga intervention modulates the stress and DNA damage levels in breast cancer patients during radiotherapy.
authors.affiliation: Genome Stability Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Birendranath
authors.initials: B
authors.lastname: Banerjee
authors.forename: H S
authors.initials: HS
authors.lastname: Vadiraj
authors.forename: Amritanshu
authors.initials: A
authors.lastname: Ram
authors.forename: Raghavendra
authors.initials: R
authors.lastname: Rao
authors.forename: Manikandan
authors.initials: M
authors.lastname: Jayapal
authors.forename: Kodaganur S
authors.initials: KS
authors.lastname: Gopinath
authors.forename: B S
authors.initials: BS
authors.lastname: Ramesh
authors.forename: Nalini
authors.initials: N
authors.lastname: Rao
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.forename: Nagarathna
authors.initials: N
authors.lastname: Raghuram
authors.forename: Sridevi
authors.initials: S
authors.lastname: Hegde
authors.forename: H R
authors.initials: HR
authors.lastname: Nagendra
authors.forename: M
authors.initials: M
authors.lastname: Prakash Hande
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D004249:DNA Damage / Q000528:radiation effects*; D005260:Female; D006801:Humans; D007194:India; D008875:Middle Aged; D011832:Radiation Injuries / Q000534:rehabilitation; D011878:Radiotherapy / Q000009:adverse effects; D013315:Stress, Psychological / Q000209:etiology / Q000628:therapy*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D015013:Yoga