title: Is Alzheimer's disease a disconnection syndrome? Evidence from a crossmodal audio-visual illusory experiment.
abstract: In Alzheimer's disease (AD), loss of connectivity in the patient's brain has been evidenced by a range of electrophysiological and neuroimaging studies. However, few neuropsychological research projects have sought to interpret the cognitive modifications following the appearance of AD in terms of a disconnection syndrome. In this paper, we sought to investigate brain connectivity in AD via the study of a crossmodal effect. More precisely, we examined the integration of auditory and visual speech information (the McGurk effect) in AD patients and matched control subjects. Our results revealed impaired crossmodal integration during speech perception in AD, which was not associated with disturbances in the separate processing of auditory and visual speech stimuli. In conclusion, our data suggest the occurrence of a specific, audio-visual integration deficit in AD, which might be the consequence of a connectivity breakdown and corroborate the observation from other studies of crossmodal deficits between the auditory and visual modalities in this population.
authors.affiliation: Memory, Resources & Research Centre, EA 2691, Lille University Hospital, Lille, France. x-delbeuck@chru-lille.fr
authors.forename: X
authors.initials: X
authors.lastname: Delbeuck
authors.forename: F
authors.initials: F
authors.lastname: Collette
authors.forename: M
authors.initials: M
authors.lastname: Van der Linden
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D000704:Analysis of Variance; D016022:Case-Control Studies; D004192:Discrimination, Psychological / Q000502:physiology; D005260:Female; D006801:Humans; D007088:Illusions / Q000502:physiology*; D008085:Lipreading; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010468:Perceptual Disorders / Q000209:etiology*; D010775:Photic Stimulation / Q000379:methods; D013067:Speech Perception / Q000502:physiology*