Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome complicated by aneurysmal aortitis.
"MAGIC syndrome" (Mouth And Genital ulcers with Inflamed Cartilage) has been proposed to describe patients with clinical features of both relapsing polychondritis and Behcet disease. A total of 18 cases have been reported with only 1 case associated with aneurysmal aortitis described in 1997. Herein, we describe a patient with MAGIC syndrome complicated by aneurysmal aortitis requiring cardiothoracic surgery and intensive immunosuppression. Monitoring for the possible development of inflammatory aortic aneurysms should thus be considered in patients with MAGIC syndrome who have persistently elevated serum inflammatory markers. If an aortic aneurysm is detected, cardiothoracic surgical referral is necessary, close monitoring for enlargement is mandatory, and intensification of immunosuppressive therapy should be considered.
Ng
Chin Soon
CS
Department of Clinical Immunology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia. chin_soon_ng@health.qld.gov.au
Hogan
Patrick
P
McKenzie
Scott
S
Gibbs
Harry
H
Strutton
Geoff
G
Wong
Richard
R
D000328:Adult; D001013:Aorta, Thoracic; D001014:Aortic Aneurysm / Q000150:complications* / Q000601:surgery; D001025:Aortitis / Q000150:complications* / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D019226:Oral Ulcer / Q000150:complications / Q000188:drug therapy; D011081:Polychondritis, Relapsing / Q000150:complications* / Q000188:drug therapy; D013577:Syndrome; D014456:Ulcer / Q000150:complications* / Q000188:drug therapy
D007166:Immunosuppressive Agents