Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke.
OBJECTIVE
Recent studies suggest that normobaric oxygen therapy (NBO) is neuroprotective in acute ischemic stroke.


METHODS
We performed multivoxel magnetic resonance spectroscopic imaging and diffusion/perfusion MRI in patients with stroke treated with NBO or room air. Imaging was performed before, during, and after therapy.


RESULTS
Voxel-based analysis showed excellent correlation between apparent diffusion coefficient values, lactate, and N-acetyl-aspartate levels at all time points. Lactate decreased during NBO and increased post-NBO. N-acetyl-aspartate decreased in patients receiving room air but not in NBO-treated patients.


CONCLUSIONS
These data suggest that NBO improves aerobic metabolism and preserves neuronal integrity in the ischemic brain.
Singhal
Aneesh B
AB
Ratai
Eva
E
Benner
Thomas
T
Vangel
Mark
M
Lee
Vallent
V
Koroshetz
Walter J
WJ
Schaefer
Pamela W
PW
Sorensen
A Gregory
AG
Gonzalez
R Gilberto
RG
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D038524:Diffusion Magnetic Resonance Imaging; D004734:Energy Metabolism; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D020521:Stroke / Q000378:metabolism / Q000473:pathology / Q000628:therapy*
D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate