title: Walking capacity and fitness to fly in patients with chronic respiratory disease.
abstract: BACKGROUND
  In this study, we tested the hypothesis that walking capacity, assessed by the 6-min walk test (6MWT), could be related to the effect of flight simulation at sea level obtained by the hypoxia-altitude simulation test (HAST) in patients with chronic respiratory disease.
  
  
  METHODS
  There were 15 patients with interstitial lung disease and 15 patients with chronic obstructive pulmonary disease who were recruited. Their baseline SpO2 values ranged from 88 to 98%. All patients performed the 6MWT and HAST according to standardized methods.
  
  
  RESULTS
  Patients covered a walking distance ranging from 185 to 592 m without stopping while experiencing no to severe dyspnea. No correlation was found between dyspnea perception during walking, walking distance, and oxygen desaturation during HAST. The oxygen desaturation induced by the 6MWT was related to that after HAST (r = 0.52, p < 0.01). The bias and limits of agreement between the oxygen desaturation after the 6MWT and after the HAST were 0.8 and -6.6 to 8.2%, respectively. The baseline SpO2 could reliably predict the oxygen desaturation during HAST (r2 = 0.51).
  
  
  CONCLUSIONS
  Our results showed that measurement of SpO2 during 6MWT can provide useful information for the preflight assessment and the in-flight oxygen prescription of patients with chronic respiratory disease.
authors.affiliation: Department of Clinical Sciences, Section of Respiratory Diseases, University of Parma, Italy. chetta@unipr.it
authors.forename: Alfredo
authors.initials: A
authors.lastname: Chetta
authors.forename: Claudia
authors.initials: C
authors.lastname: Castagnetti
authors.forename: Marina
authors.initials: M
authors.lastname: Aiello
authors.forename: Francesco
authors.initials: F
authors.lastname: Sergio
authors.forename: Nicola
authors.initials: N
authors.lastname: Fabiano
authors.forename: Panagiota
authors.initials: P
authors.lastname: Tzani
authors.forename: Emilio
authors.initials: E
authors.lastname: Marangio
authors.forename: Dario
authors.initials: D
authors.lastname: Olivieri
mesh_terms: D000328:Adult; D000337:Aerospace Medicine; D000368:Aged; D000369:Aged, 80 and over; D004780:Environment, Controlled; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000503:physiopathology; D015203:Reproducibility of Results; D017751:Safety Management; D016138:Walking