Monitoring of concordance in growth hormone therapy.
Concordance with growth hormone (GH) therapy in 75 children was objectively assessed using data on GP prescriptions over 12 months. 23% missed >2 injections/week. Lower concordance was associated with longer duration on GH therapy (p<0.005), lack of choice of delivery device (p<0.005) and short prescription durations (p<0.005), and predicted lower height velocities (p<0.05).
Kapoor
R R
RR
Department of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Burke
S A
SA
Sparrow
S E
SE
Hughes
I A
IA
Dunger
D B
DB
Ong
K K
KK
Acerini
C L
CL
D000293:Adolescent; D001827:Body Height / Q000187:drug effects; D002648:Child; D003430:Cross-Sectional Studies; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy* / Q000503:physiopathology; D019382:Human Growth Hormone / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010349:Patient Compliance; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
D011994:Recombinant Proteins; D019382:Human Growth Hormone