title: [Effect of diet control combined with aerobic exercise on the metabolic syndrome].
abstract: OBJECTIVE
  To observe the efficacy of diet control and aerobic exercises on the patients with metabolic syndrome(MS).
  
  
  METHODS
  Sixty sedentary patients with MS were randomly divided into a diet control group, an aerobic exercise group, and a diet control combined with aerobic exercise group, each group with 20 persons. Patients in the simple diet control group ate a low-salt, low-cholesterol, low-calorie and high-cellulose diet; patients in the simple aerobic exercises group performed aerobic exercise 30 minutes every time, 3-5 times per week for 12 weeks; while patients in the combination therapy group performed aerobic exercises and diet control. Fasting serum insulin and free fatty acid (FFA) were measured by radio immunity and enzyme-colorimetric method. Serum leptin concentration was measured by enzyme linked immunosorbent assay (ELISA). Homeostasis model assessment (HOMA) insulin resistance index was calculated using the homeostasis model assessment equation. Twenty healthy subjects were selected as the control group.
  
  
  RESULTS
  Serum concentration of FFA, blood pressure, and leptin and insulin resistance index (IRI)of patients with MS significantly increased compared with those of the controls. After 12 weeks, IRI and body mass index (BMI)significantly decreased but blood fat and leptin did not change significantly in the diet control group. IRI and BMI significantly decreased, and triglyceride, FFA and leptin also significantly decreased in the combination therapy group.
  
  
  CONCLUSIONS
  Simple diet control and aerobic exercises are beneficial for patients with MS. It could significantly improve the effect of diet control combined with aerobic exercises on patients with metabolic syndrome.
authors.affiliation: Department of Gerontology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.forename: Xiong-Wei
authors.initials: XW
authors.lastname: Xie
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Liu
authors.forename: Jia-Mei
authors.initials: JM
authors.lastname: Yao
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D004032:Diet; D015444:Exercise; D005081:Exercise Therapy; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000628:therapy*; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D005230:Fatty Acids, Nonesterified; D020738:Leptin; D014280:Triglycerides