[Effect of selenium-enriched garlic on chronic gastritis of the glandular stomach of Mongolian gerbils induced by H. pylori].
OBJECTIVE
To detect the therapeutic effect of selenium-enriched garlic (SeG) on chronic gastritis.


METHODS
Chronic gastritis was induced of the glandular stomach of male Mongolian Gerbils via gastric instillation of H. pylori TN2 strain once every 4 days for 5 consecutive times followed by random classification into six groups. Fresh SeG suspension was administrated daily at dosages of 4.70, 1.5, 0.47, 0.15 g.kg(-1).d(-1) for four weeks. The gerbils in the positive control group were treated with omeprazole, clarithromycin, and amoxicillin for one week. The gerbils were killed for pathological examination four weeks after SeG-treatment.


RESULTS
Chronic gastritis (CAG), low-grade dysplasia or gastric intraepithelial neoplasia (DYS/GIN) were observed among 77% and 38.5% of the 13 H. pylori-treated animals in the negative control group, respectively; whereas 40% and 26.7% in the positive control group (n = 15), respectively. The incidences of CAG and DYS/GIN in the SeG groups (n = 21 - 27) were reduced dose-dependently, 16.7% - 38.7% and 11.1% - 14.3% for CAG and DYS/GIN, respectively.


CONCLUSIONS
SeG administration inhibits the development and progression of CAG induced by H. pylori remarkably.
Gu
Lian-Kun
LK
Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing 100036, China.
Zhou
Ping
P
Zhou
Jing
J
Wang
Ru-Ming
RM
Yang
Wen-Jie
WJ
Deng
Da-Jun
DJ
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D005737:Garlic; D005756:Gastritis / Q000188:drug therapy* / Q000382:microbiology; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D008297:Male; D008517:Phytotherapy; D012643:Selenium / Q000627:therapeutic use*
D012643:Selenium