title: SUMO-specific proteases: a twist in the tail.
abstract: The small ubiquitin-like modifier (SUMO) is involved in many cellular processes and is required for normal growth and development in all eukaryotes. Whereas lower eukaryotes have a single version of SUMO, higher eukaryotes have three versions: SUMO-1, -2 and -3. Similarly to most other ubiquitin-like proteins, the primary translation products of the SUMO genes need to be proteolytically processed to expose the C-terminal glycine that will be linked to lysine side chains in substrates. Processing of SUMO precursors is mediated by SUMO-specific proteases that also remove SUMO from modified proteins and depolymerise poly-SUMO chains.
authors.affiliation: Sir James Black Centre, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. r.t.hay@dundee.ac.uk
authors.forename: Ronald Thomas
authors.initials: RT
authors.lastname: Hay
mesh_terms: D003546:Cysteine Endopeptidases / Q000145:classification / Q000235:genetics / Q000378:metabolism; D010450:Endopeptidases / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans / Q000145:classification / Q000235:genetics; D008958:Models, Molecular; D010802:Phylogeny; D011487:Protein Conformation; D020033:Protein Isoforms / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D020033:Protein Isoforms; D029701:Saccharomyces cerevisiae Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; D025801:Ubiquitin; D010450:Endopeptidases; C405949:ULP2 protein, S cerevisiae; D003546:Cysteine Endopeptidases; C118083:Ulp1 protease