An update on primary progressive aphasia.
Primary progressive aphasia is a neurodegenerative syndrome characterized by a relentless dissolution of language but relative sparing of other cognitive domains during the initial stages of the disease. Substantial progress has been made in understanding the clinical characteristics, imaging, genetics, and neuropathology of this syndrome. This article reviews the clinical criteria for diagnosing primary progressive aphasia and some of the more recent research advances in this field.
Rogalski
Emily
E
Cognitive Neurology and Alzheimer's Disease Center and Department of Neurology, Northwestern University, 320 E. Superior Street, Searle Building 11-453, Chicago, IL 60657, USA. rogalski@northwestern.edu
Mesulam
Marsel
M
D018888:Aphasia, Primary Progressive / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D003704:Dementia / Q000150:complications* / Q000503:physiopathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000150:complications* / Q000503:physiopathology; D014705:Verbal Behavior / Q000502:physiology