title: Microscopic dose to lung from inhaled alpha emitters in humans.
abstract: Because of the short range of alpha particles in tissue, the degree of uniformity of irradiation of the lung varies greatly depending on the form of the inhaled material. Animal studies have shown that the degree of dose uniformity influences the risk of lung cancer. This study investigates the radiation dose distribution of plutonium in human lung. Numerical maps of tissue configuration and target cell locations are obtained from histological sections of human lung tissue stained to enhance the identification of putative cell types for parenchymal lung cancers, i.e. alveolar type II cells and Clara cells. Monte Carlo simulations are used to obtain dose distribution around individual particles, and these distributions are used to compute dose distribution in volumes of lung tissue. Lung dose is characterised both by the degree of non-uniformity of irradiation and the relative degree of irradiation of all tissue versus the special cells of interest.
authors.affiliation: Private Consultant.
authors.forename: Joseph
authors.initials: J
authors.lastname: Diel
authors.forename: Maxim
authors.initials: M
authors.lastname: Belosokhov
authors.forename: Sergey
authors.initials: S
authors.lastname: Romanov
authors.forename: Raymond
authors.initials: R
authors.lastname: Guilmette
mesh_terms: D000336:Aerosols / Q000032:analysis / Q000493:pharmacokinetics*; D000512:Alpha Particles; D003198:Computer Simulation; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D008168:Lung / Q000378:metabolism*; D008832:Microchemistry / Q000379:methods; D008954:Models, Biological; D009928:Organ Specificity; D011005:Plutonium / Q000032:analysis* / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*
chemical_list: D000336:Aerosols; D011005:Plutonium