Interaction study of paracetamol with saturated (capric) and unsaturated (oleic) fatty acids.
Interaction study of paracetamol with saturated and unsaturated fatty acids, namely, capric and oleic acid have been performed by using serial dilution method, release behavior, FT-IR, and DSC study. Preliminary investigations by release studies indicated the possibility of interaction between paracetamol and fatty acids. UV-studies failed to detect any interaction between paracetamol and fatty acids. The possibility of hydrogen bonding between amino group of paracetamol and carbonyl group of fatty acids was revealed by FT-IR study. Polymorphic transition of paracetamol in the binary sample of paracetamol-capric acid was identified by DSC studies. However, no such possibility was detected in paracetamol-oleic acid mixture.
Misra
Arun Kumar
AK
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, India. arunudps@rediffmail.com
Misra
Manju
M
Panpalia
Gopal Madanlal
GM
Dorle
Avinash Keshav
AK
D000082:Acetaminophen / Q000737:chemistry*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D003652:Decanoic Acids / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D006860:Hydrogen Bonding; D019301:Oleic Acid / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
D018712:Analgesics, Non-Narcotic; D003652:Decanoic Acids; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D019301:Oleic Acid; D000082:Acetaminophen; C031071:decanoic acid