title: Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke.
abstract: OBJECTIVE
  Recent studies suggest that normobaric oxygen therapy (NBO) is neuroprotective in acute ischemic stroke.
  
  
  METHODS
  We performed multivoxel magnetic resonance spectroscopic imaging and diffusion/perfusion MRI in patients with stroke treated with NBO or room air. Imaging was performed before, during, and after therapy.
  
  
  RESULTS
  Voxel-based analysis showed excellent correlation between apparent diffusion coefficient values, lactate, and N-acetyl-aspartate levels at all time points. Lactate decreased during NBO and increased post-NBO. N-acetyl-aspartate decreased in patients receiving room air but not in NBO-treated patients.
  
  
  CONCLUSIONS
  These data suggest that NBO improves aerobic metabolism and preserves neuronal integrity in the ischemic brain.
authors.forename: Aneesh B
authors.initials: AB
authors.lastname: Singhal
authors.forename: Eva
authors.initials: E
authors.lastname: Ratai
authors.forename: Thomas
authors.initials: T
authors.lastname: Benner
authors.forename: Mark
authors.initials: M
authors.lastname: Vangel
authors.forename: Vallent
authors.initials: V
authors.lastname: Lee
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Koroshetz
authors.forename: Pamela W
authors.initials: PW
authors.lastname: Schaefer
authors.forename: A Gregory
authors.initials: AG
authors.lastname: Sorensen
authors.forename: R Gilberto
authors.initials: RG
authors.lastname: Gonzalez
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D038524:Diffusion Magnetic Resonance Imaging; D004734:Energy Metabolism; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D020521:Stroke / Q000378:metabolism / Q000473:pathology / Q000628:therapy*
chemical_list: D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate