title: Metastatic esophageal adenocarcinoma presenting in the iris.
abstract: OBJECTIVE
  To report a case of metastatic esophageal adenocarcinoma presenting as an acute primary iris tumor of unknown origin.
  
  
  METHODS
  Interventional, clinicopathologic case report.
  
  
  METHODS
  A 47-year-old healthy man sought treatment for a three-week history of a progressively enlarging red spot on the left iris. Presentation, local and systemic evaluation, and treatment are described.
  
  
  RESULTS
  Iris biopsy revealed the lesion represented metastasis, and a systemic evaluation later revealed the primary source as esophageal adenocarcinoma. The patient began systemic chemotherapy.
  
  
  CONCLUSIONS
  Metastatic iris lesions can have atypical presentations. Tissue biopsy, tumor antigens, and a thorough systemic evaluation are crucial in identification of primary tumors in cases of unknown metastatic origin.
authors.affiliation: Eye Consultants of Atlanta, Cornea & External Disease Section, Atlanta, Georgia, USA. lee0003@aol.com
authors.forename: W Barry
authors.initials: WB
authors.lastname: Lee
authors.forename: Harold M
authors.initials: HM
authors.lastname: Sy
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Filip
authors.forename: Hans E
authors.initials: HE
authors.lastname: Grossniklaus
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000188:drug therapy / Q000556:secondary*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D000069287:Capecitabine; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D015251:Epirubicin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D015811:Iris Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin
chemical_list: D014408:Biomarkers, Tumor; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D003841:Deoxycytidine; D015251:Epirubicin; D000069287:Capecitabine; D005472:Fluorouracil