title: Tone duration mismatch negativity deficits predict impairment of executive function in schizophrenia.
abstract: Impairment in mismatch negativity (MMN) potentials is a robust finding in schizophrenia. There are few studies which examined the correlation between MMN deficits and neuropsychological performances. The purpose of this study was to investigate the relationship between deficits of tone duration MMN and various neuropsychological measures in schizophrenic patients (n=23). The results demonstrated a significant correlation between low MMN amplitude and poor performances of executive function in Wisconsin Card Sorting Test, Stroop Test and Trail Making Test. Our finding suggests MMN deficits in schizophrenia predict deficits of executive function and might reflect ongoing functional abnormality of fronto-temporal interaction.
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Hokkaido University N15, W7, Sapporo 060-8638, Japan. toyomaki@med.hokudai.ac.jp
authors.forename: Atsuhito
authors.initials: A
authors.lastname: Toyomaki
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kusumi
authors.forename: Testsuaki
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kako
authors.forename: Koki
authors.initials: K
authors.lastname: Ito
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Koyama
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D001308:Auditory Perceptual Disorders / Q000209:etiology*; D003072:Cognition Disorders / Q000150:complications* / Q000209:etiology*; D003265:Contingent Negative Variation / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology*; D012559:Schizophrenia / Q000150:complications*; D013223:Statistics as Topic