title: Timing of dose-finding studies: before or after completion of a randomized clinical trial?
authors.forename: John N
authors.initials: JN
authors.lastname: van den Anker
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D007231:Infant, Newborn; D007234:Infant, Premature; D007442:Intubation, Intratracheal / Q000379:methods*; D015742:Propofol / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016032:Randomized Controlled Trials as Topic
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol