Immunologic profile and outcome of childhood acute lymphoblastic leukemia (ALL) in Morocco.
Immunophenotyping in leukemia offers a precise delineation of the hematopoietic lineage and differentiation stage of the malignant cell. In this study, we used flow cytometry to determine the frequency of the immunologic types of acute lymphoblastic leukemia (ALL) in Moroccan children. We analyzed 100 samples from ALL patients within an age ranging from 6 months to 16 years presented over a 4-year period (1996 to 2000). Immunophenotyping allowed classification into 2 major categories: T-ALL (37%) and B-ALL (63%), with a higher percentage of males (69%). Comparison of the clinical characteristics showed that the frequency of splenomegaly was similar in B-ALL and T-ALL patients (53% and 47%, respectively). Hepatomegaly and mediastinal masses were more often associated with T-ALL (62% and 71%, respectively). Splenomegaly, hepatomegaly, and mediastinal masses were more frequent in immature than mature B-ALL, whereas the reverse was observed for T-ALL. Complete remission was obtained in 88% and 84% of B-ALL and T-ALL, respectively and relapse after 1 year occurred in 30% and 37% of cases, respectively. CD10 expressing B-ALL showed a slightly higher complete remission rate, whereas the reverse was observed for CD10 expressing T-ALL. The overall 5-year survival rate of ALL was 38%, whereas patients with B-ALL showed better survival than children with T-ALL.
Dakka
Nadia
N
Laboratoire de Biochimie-Immunologie, Université Mohammed V, Faculté des Sciences, Rabat, Morocco. nadiadakka@yahoo.fr
Bellaoui
Hicham
H
Khattab
Mohammed
M
Brahimi-Horn
Marie C
MC
Aoued
Leila
L
Bouzid
Nadia
N
Bakri
Youssef
Y
Benjouad
Abdelaziz
A
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008297:Male; D009018:Morocco / Q000453:epidemiology; D015260:Neprilysin / Q000032:analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000276:immunology* / Q000401:mortality*
D015260:Neprilysin