title: The denoising of Monte Carlo dose distributions using convolution superposition calculations.
abstract: Monte Carlo (MC) dose calculations can be accurate but are also computationally intensive. In contrast, convolution superposition (CS) offers faster and smoother results but by making approximations. We investigated MC denoising techniques, which use available convolution superposition results and new noise filtering methods to guide and accelerate MC calculations. Two main approaches were developed to combine CS information with MC denoising. In the first approach, the denoising result is iteratively updated by adding the denoised residual difference between the result and the MC image. Multi-scale methods were used (wavelets or contourlets) for denoising the residual. The iterations are initialized by the CS data. In the second approach, we used a frequency splitting technique by quadrature filtering to combine low frequency components derived from MC simulations with high frequency components derived from CS components. The rationale is to take the scattering tails as well as dose levels in the high-dose region from the MC calculations, which presumably more accurately incorporates scatter; high-frequency details are taken from CS calculations. 3D Butterworth filters were used to design the quadrature filters. The methods were demonstrated using anonymized clinical lung and head and neck cases. The MC dose distributions were calculated by the open-source dose planning method MC code with varying noise levels. Our results indicate that the frequency-splitting technique for incorporating CS-guided MC denoising is promising in terms of computational efficiency and noise reduction.
authors.affiliation: Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, USA.
authors.forename: I
authors.initials: I
authors.lastname: El Naqa
authors.forename: J
authors.initials: J
authors.lastname: Cui
authors.forename: P
authors.initials: P
authors.lastname: Lindsay
authors.forename: G
authors.initials: G
authors.lastname: Olivera
authors.forename: J O
authors.initials: JO
authors.lastname: Deasy
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001822:Body Burden; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009010:Monte Carlo Method; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity