Myotonic response induced by inhibitors of cholesterol biosynthesis.
Steroid inhibitors of cholesterogenesis containing nitrogen-substituted side chains induced electromyographic myotonia in rats. Cholesterol reduction or desmosterol accumulation, per se, did not cause myotonia, and cholestrol feeding prevented drug-induced myotonia. Desmosterol accumulation in combination with a specific drug effect may cause the observed myotonia.
Winer
N
N
Klachko
D M
DM
Baer
R D
RD
Langley
P L
PL
Burns
T W
TW