[Meta-analysis on the relationship between IL8-251 gene polymorphism and gastric cancer].
OBJECTIVE
To evaluate the relationship between IL8-251 gene polymorphisms and gastric cancer.


METHODS
Literatures were reviewed and selected based on the criteria for inclusion. The Meta-analysis software, REVMAN 4.2, was applied to check the heterogeneity across the studies and calculating the pooled OR.


RESULTS
Total of 2114 cases and 2505 controls from 8 studies for IL8-251 were included. The chi(2) value was 21.48 (P = 0.003), and the pooled OR of (AA + AT) vs. TT was 1.12 (95% CI 0.90 - 1.40). Large heterogeneity was found among the studies. After the sensitivity analysis, the pooled OR of (AA + AT) vs. TT 1.21 (95% CI 1.06 - 1.39).


CONCLUSIONS
IL8-251-A allele might be associated with higher risk of developing gastric cancer.
Lu
Yan
Y
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Wang
Zi-Dun
ZD
Shen
Jing
J
Xu
Yao-Chu
YC
D000483:Alleles; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics*
D016209:Interleukin-8