title: Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe.
abstract: This investigation highlighted the risk of cancer in 8074 HIV-infected people and in 2875 transplant recipients in Italy and France. Observed and expected numbers of cancer were compared through sex- and age-standardised incidence ratios (SIRs) and 95% confidence intervals (CIs). After 15 years of follow-up, the cumulative probability of cancer was 14.7% in transplant recipients and 13.3% in HIV-positives. The SIRs for all cancers were 9.8 in HIV-positives and 2.2 in transplants. Kaposi's sarcoma (SIR=451 in HIV-positives, 125 in transplants) and non-Hodgkin lymphoma (SIR=62 and 11.1, respectively) were the most common cancers. A significantly increased SIR for liver cancer also emerged in both groups. The risk of lung cancer was significantly elevated in heart transplant recipients (SIR=2.8), and of borderline statistical significance in HIV-positive people (95% CI:0.9-2.8). Immune depression entails a two-fold increased overall risk of cancers, mainly related to cancers associated with a viral aetiology.
authors.affiliation: Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, via F Gallini, 2, 33081 Aviano (PN), Italy. serrainod@cro.it
authors.forename: Diego
authors.initials: D
authors.lastname: Serraino
authors.forename: Pierluca
authors.initials: P
authors.lastname: Piselli
authors.forename: Ghil
authors.initials: G
authors.lastname: Busnach
authors.forename: Patrizia
authors.initials: P
authors.lastname: Burra
authors.forename: Franco
authors.initials: F
authors.lastname: Citterio
authors.forename: Eloisa
authors.initials: E
authors.lastname: Arbustini
authors.forename: Umberto
authors.initials: U
authors.lastname: Baccarani
authors.forename: Emanuela
authors.initials: E
authors.lastname: De Juli
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Pozzetto
authors.forename: Stefania
authors.initials: S
authors.lastname: Bellelli
authors.forename: Jerry
authors.initials: J
authors.lastname: Polesel
authors.forename: Christian
authors.initials: C
authors.lastname: Pradier
authors.forename: Luigino
authors.initials: L
authors.lastname: Dal Maso
authors.forename: Claudio
authors.initials: C
authors.lastname: Angeletti
authors.forename: Maria Patrizia
authors.initials: MP
authors.lastname: Carrieri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Rezza
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D014180:Transplantation / Q000009:adverse effects*