title: Topical betablocker use can result in inconclusive dobutamine stress echocardiography in patients with glaucoma.
abstract: Dobutamine stress echocardiography is a well-established method to assess coronary artery disease, of which sensitivity has been enhanced by adding atropine at the end of the protocol. Individuals with glaucoma, a disease with a high prevalence in patients with cardiac diseases older than 40 years, cannot benefit from the use of atropine as it is contraindicated for this group of patients. Additionally, these individuals are often treated with topical betablockers (eye drops), which can have systemic effects by decreasing cardiac frequency, blood pressure and pulmonary capacity. The aim of our study was to verify whether a possible systemic effect caused by the use of these eye drops, yielding a low chronotropic response, could result in inconclusive dobutamine stress echocardiography in patients with glaucoma.
authors.affiliation: Universidade Federal de São Paulo-UNIFESP/EPM, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil. acordovil@cardiol.br
authors.forename: Adriana
authors.initials: A
authors.lastname: Cordovil
authors.forename: Fernando Q
authors.initials: FQ
authors.lastname: Matos
authors.forename: Orlando
authors.initials: O
authors.lastname: Campos Filho
authors.forename: Augusto
authors.initials: A
authors.lastname: Paranhos
authors.forename: Ana Clara T
authors.initials: AC
authors.lastname: Rodrigues
authors.forename: Márcia V
authors.initials: MV
authors.lastname: Albernaz
authors.forename: Angelo A V de
authors.initials: AA
authors.lastname: Paola
authors.forename: Antonio Carlos C
authors.initials: AC
authors.lastname: Carvalho
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000009:adverse effects; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000000981:diagnostic imaging; D004280:Dobutamine / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D025401:Echocardiography, Stress; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D012146:Rest
chemical_list: D002316:Cardiotonic Agents; D009883:Ophthalmic Solutions; D004280:Dobutamine