title: Evaluation of the surgical treatment of nasal polyposis. II: Influence of a non-specific bronchial hyperresponsiveness.
abstract: CONCLUSIONS
  Bronchial hyperresponsiveness (BHR) is not a risk factor for surgery in patients with nasal polyposis (NP).
  
  
  OBJECTIVE
  Management of NP should be primarily medical, and surgery should not be envisaged before a trial of dual steroid therapy. In patients with severe NP resistant to a strict medical treatment, endoscopic sinus surgery is performed, but no prognostic factor for efficacy of surgery is obvious. Some authors suggest that asthma could be a major risk for ineffectiveness of surgery. The aim of this study was to evaluate whether the presence of BHR can be considered a risk factor for ineffectiveness of surgery.
  
  
  METHODS
  Surgery (with associated medical treatment) was evaluated over a mean follow-up period of 74 months. A total of 63 subjects without and 131 subjects with BHR were operated according to a standardized protocol.
  
  
  RESULTS
  The present study shows that combined surgery and corticosteroid therapy is effective in the treatment of severe NP, producing significant and long-term improvements in symptoms and in the size of nasal polyps. BHR did not influence the outcome. Moreover, the mean amount of prednisolone and beclomethasone necessary after surgery was similar in the two groups.
authors.affiliation: Department of Oto-Rhino-Laryngology - Head Neck Surgery, European Hospital Georges Pompidou, University Paris-Descartes, School of Medicine, Paris, France. pierre.bonfils@egp.aphp.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Bonfils
authors.forename: Paul
authors.initials: P
authors.lastname: Avan
mesh_terms: D000281:Administration, Intranasal; D001507:Beclomethasone / Q000008:administration & dosage*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D003131:Combined Modality Therapy; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000502:physiology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D015995:Prevalence; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D001507:Beclomethasone