Adiponectin, obesity and atherosclerosis.
The circulating protein adiponectin has been the subject of immense interest ever since it was first discovered in the mid-1990s. The protein is uniquely produced and secreted by mature adipocytes and is believed to have important anti-inflammatory and anti-diabetic effects; low levels have been shown to be predictive of future type 2 diabetes and cardiovascular disease. This review discusses adiponectin in relation to obesity, inflammation, insulin resistance and atherosclerosis.
Behre
C J
CJ
Wallenberg Laboratory for Cardiovascular Research, Institute of Internal Medicine, Sahlgrenska University Hospital, Göteborg University, Gothenburg, Sweden. behre@wlab.gu.se
D017667:Adipocytes / Q000378:metabolism; D052242:Adiponectin / Q000502:physiology*; D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000276:immunology; D009765:Obesity / Q000378:metabolism*
D052242:Adiponectin; D016207:Cytokines