[Generalized congenital lipodystrophy: correlation with leptin and other biochemical parameters].
OBJECTIVE
To correlate serum leptin and insulin levels, and the glucosic profile of 21 patients shared in diabetics and non diabetics with Congenital Generalized Lipodystrophy (CGL).


METHODS
In a prospective study, were dosed serum leptin level with radioimmunoassay technique, fasting plasma glucose through of the glucoseoxidase-peroxidase reaction, the hemoglobin glycate using the technique microchromatography for ionic exchange resin and insulin through immunoassay system. The fructosamine concentration serum was determinated for reduction nitroblue tetrazolium method. The Student's test was used to compare results between the groups and the correlation "r" coefficient to analise the relation among the several variants studied, with significant level of 5% (p < 0.05). All the statistical procedures were performed using the Excel by Microsoft and the Statistic program for Windows by StatSoft, Inc. version 5.1 edition 97.


RESULTS
Leptin decreased on the most patients, showing no statistically significant difference between the groups. Also there wasn't difference statistically significant (p = 0.9542) of the insulin's value between diabetics and non diabetics.


CONCLUSIONS
The hyperinsulinism and the hypoleptinemia occurred independently of diabetes in the CGL's patients and this can be due to the natural history of disease, in which the raise insulin levels precede the initial diabetes mellitus and the low leptin levels were related to the lipoatrophy.
Santos
Maria Goretti do Nascimento
MG
Departamento de Análises Clínicas e Toxicológicas do Centro de Ciências da Saúde na Universidade Federal do Rio Grande do Norte (UFRN). goretti@ufrnet.br
de Medeiros
Tereza Maria Dantas
TM
Baracho
Maria de Fátima Paiva
Mde F
Brandão-Neto
José
J
Gurgel
Aline Maria Cavalcante
AM
da Silva
Ana Séphora Costa
AS
D000273:Adipose Tissue / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D003923:Diabetes Mellitus, Lipoatrophic / Q000097:blood*; D005260:Female; D019270:Fructosamine / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D052497:Lipodystrophy, Congenital Generalized / Q000097:blood*; D008297:Male; D011446:Prospective Studies
D001786:Blood Glucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D020738:Leptin