title: agr-Amanitin Tolerance in Mycophagous Drosophila.
abstract: Six species of Drosophila were tested for tolerance to the mushroom toxin alpha-amanitin, a potent inhibitor of RNA polymerase II. Three nonmycophagous species-D. melanogaster, D. immigrans, and D. pseudoobscura-showed very low survival and long development times in the presence of amanitin. Three mycophagous species-D. putrida, D. recens, and D. tripunctata-showed little or no sensitivity. Analysis in vitro indicated that this tolerance is not based on alteration of the molecular structure of RNA polymerase II.
authors.forename: J
authors.initials: J
authors.lastname: Jaenike
authors.forename: D A
authors.initials: DA
authors.lastname: Grimaldi
authors.forename: A E
authors.initials: AE
authors.lastname: Sluder
authors.forename: A L
authors.initials: AL
authors.lastname: Greenleaf