title: Clinical features and physiological response to a test meal in purging disorder and bulimia nervosa.
abstract: BACKGROUND
  Recent data suggest that purging disorder, a recently characterized form of eating disorder not otherwise specified, may be worthy of specific delineation in nosological schemes. However, more data are needed to determine how purging disorder differs from bulimia nervosa.
  
  
  OBJECTIVE
  To examine clinical features and subjective as well as objective physiological responses to a standardized test meal in purging disorder compared with bulimia nervosa and controls.
  
  
  METHODS
  Study visit 1 included psychological assessments with structured clinical interviews and questionnaires. Study visit 2 included assessment of test-meal responses.
  
  
  METHODS
  Participants recruited from the community completed test-meal studies in a General Clinical Research Center.
  
  
  METHODS
  Women with DSM-IV bulimia nervosa-purging subtype (n = 37) and purging disorder (n = 20) and non-eating disorder controls (n = 33) with a body mass index (calculated as weight in kilograms divided by height in meters squared) between 18.5 and 26.5 who were free of psychotropic medications.
  
  
  METHODS
  Assessments of eating disorder severity, postprandial cholecystokinin response, and subjective responses to test meals.
  
  
  RESULTS
  Eating abnormalities were significantly elevated in participants with purging disorder and bulimia nervosa compared with controls but did not differ between eating disorder groups. Participants with purging disorder demonstrated significantly greater postprandial cholecystokinin release compared with participants with bulimia nervosa (t(76.44) = 2.51; P = .01) and did not differ significantly from controls (t(75.93) = 0.03; P = .98). Participants with purging disorder reported significantly greater postprandial fullness and gastrointestinal distress compared with participants with bulimia nervosa and controls.
  
  
  CONCLUSIONS
  Purging disorder is a clinically significant disorder of eating that appears to be distinct from bulimia nervosa on subjective and physiological responses to a test meal. Findings support further consideration of purging disorder for inclusion in the classification of eating disorders. Future studies on the psychobiology of purging disorder are needed to understand the propensity to purge in the absence of binge eating.
authors.affiliation: Department of Psychology, The University of Iowa, Iowa City, IA 52242, USA. pamela-keel@uiowa.edu
authors.forename: Pamela K
authors.initials: PK
authors.lastname: Keel
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Wolfe
authors.forename: Rodger A
authors.initials: RA
authors.lastname: Liddle
authors.forename: Kyle P
authors.initials: KP
authors.lastname: De Young
authors.forename: David C
authors.initials: DC
authors.lastname: Jimerson
mesh_terms: D000328:Adult; D001066:Appetite / Q000502:physiology; D015992:Body Mass Index; D052018:Bulimia Nervosa / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D002766:Cholecystokinin / Q000097:blood*; D035061:Control Groups; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004435:Eating / Q000502:physiology* / Q000523:psychology; D001068:Feeding and Eating Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D005260:Female; D006801:Humans; D006815:Hunger / Q000502:physiology; D010555:Personality Inventory / Q000706:statistics & numerical data; D019518:Postprandial Period / Q000502:physiology*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012527:Satiation / Q000502:physiology; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014839:Vomiting / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology
chemical_list: D002766:Cholecystokinin