title: Cost-effectiveness of psoriasis therapy with etanercept in Germany.
abstract: BACKGROUND
  We estimated the cost-effectiveness of intermittent therapy with etanercept in patients with moderate-to-severe plaque-type psoriasis in comparison to non-systemic therapy in Germany.
  
  
  METHODS
  We performed a cost-utility analysis using the endpoint costs per quality-adjusted life year gained (costs/QALY). For this purpose, we adapted a UK-based Markov model by means of resource use data that we derived from a German cost study. Efficacy data, information on frequency of adverse events and changes in quality of life were derived from three pooled clinical trials. We extrapolated the further course of the disease and its treatment over a 10 year course.
  
  
  RESULTS
  For patients with an initial Psoriasis Area and Severity Index (PASI) > 10 and a Dermatology Life Quality Index (DLQI) > 10 the incremental cost-effectiveness ratio (ICER) for etanercept compared to non-systemic therapy was 45,491 euro/QALY. For patients with PASI and DLQI > 15 costs/QALY were 32,058 euro and among patients with severe plaque psoriasis (DLQI and PASI > 20) 18,154 euro.
  
  
  CONCLUSIONS
  According to internationally accepted levels of cost-effectiveness thresholds, the intermittent treatment of (moderate to) severe plaque-type psoriasis with etanercept is a cost-effective measure within the German healthcare system.
authors.affiliation: Institute for Empirical Health Economics, Burscheid, Germany.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Heinen-Kammerer
authors.forename: Dietmar
authors.initials: D
authors.lastname: Daniel
authors.forename: Lioba
authors.initials: L
authors.lastname: Stratmann
authors.forename: Reinhard
authors.initials: R
authors.lastname: Rychlik
authors.forename: Wolf-Henning
authors.initials: WH
authors.lastname: Boehncke
mesh_terms: D000328:Adult; D003362:Cost-Benefit Analysis; D000068800:Etanercept; D005260:Female; D005858:Germany / Q000453:epidemiology; D017048:Health Care Costs / Q000706:statistics & numerical data*; D006801:Humans; D007074:Immunoglobulin G / Q000191:economics* / Q000627:therapeutic use*; D008297:Male; D018803:Models, Economic; D011565:Psoriasis / Q000188:drug therapy* / Q000191:economics* / Q000453:epidemiology; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*
chemical_list: D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D000068800:Etanercept