title: Atypical bronchial thickening and ulceration: a rare radiological finding in Wegener's granulomatosis.
abstract: We report the case of a 55-year-old male patient who presented with non-specific pulmonary symptoms (cough, haemoptysis, fever up to 39 degrees C, night sweats and weight loss). After empirical antibiotic therapy prescribed by his primary care physician, the patient showed no improvement in symptoms. Laboratory findings were: elevated C-reactive protein and C-ANCA, leukocytosis and thrombocytosis, and anaemia. Chest radiography showed disseminated nodules bilaterally. On multidetector-row computed tomography (MDCT), the bronchial walls showed a significant thickening and extensive peribronchiolar consolidations. Bronchoscopy revealed diffuse erythema of the tracheobronchial mucosa with diffusely scattered white plaques. Histopathology described a multifocal ulcerative bronchitis with underlying chronic bronchitis. These findings in combination with the laboratory data lead to the diagnosis of Wegener's granulomatosis. Consequently, we started with an immunosuppressive therapy. Chest radiography after 10 days showed marked resolution of the infiltrates. Within 1 month, the patient became asymptomatic.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Ulm, D-89081 Ulm, Germany. sandra.pauls@uniklinik-ulm.de
authors.forename: S
authors.initials: S
authors.lastname: Pauls
authors.forename: S
authors.initials: S
authors.lastname: Krüger
authors.forename: T F E
authors.initials: TF
authors.lastname: Barth
authors.forename: H-J
authors.initials: HJ
authors.lastname: Brambs
authors.forename: M S
authors.initials: MS
authors.lastname: Juchems
mesh_terms: D001706:Biopsy / Q000379:methods; D001980:Bronchi / Q000473:pathology*; D001982:Bronchial Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014456:Ulcer / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology