title: Correlation of scoliotic curvature with Z-score bone mineral density and body mass index in patients with osteogenesis imperfecta.
abstract: METHODS
  A cross-sectional radiographic and clinical study of patients with osteogenesis imperfecta (OI).
  
  
  OBJECTIVE
  To determine demographic, anthropometric, and radiographic parameters that correlate with development of scoliosis in patients with OI.
  
  
  BACKGROUND
  Despite the relatively high prevalence of scoliosis in patients with OI and its clinical significance, little is known about demographic and anthropometric parameters that correlate with the development of scoliosis.
  
  
  METHODS
  Clinical records and spinal radiographs of 19 OI patients were reviewed. There were 5 male and 14 female patients with an average age of 14.2 years (range, 4-20 years). Seven patients were Sillence Type I and 12 patients were Type III. The Cobb angle of scoliosis was analyzed for correlations with age, body mass index (BMI), physical capability, leg-length discrepancy, Z-score bone mineral density (BMD) in the lumbar spine, thoracic kyphosis angle, and lumbar lordosis angle by using Pearson's correlation method. A probability of less than 0.05 was considered statistically significant.
  
  
  RESULTS
  The average Cobb angle of scoliosis was 25.2 degrees (range, 5 degrees-108 degrees) including 6 patients with an angle of > or = 30 degrees. Five of these 6 patients were Sillence Type III. Statistical analysis showed a significant positive correlation between the extent of scoliosis and BMI, as well as leg-length discrepancy. There was an inverse correlation between the extent of scoliotic curvature and the Z-score BMD as well as the thoracic kyphosis angle.
  
  
  CONCLUSIONS
  The correlation of scoliosis with the Z-score BMD and BMI supports the pathology of scoliosis based on vertebral fragility. Proper management of BMD and BMI may have therapeutic value in delaying the progression of scoliosis in patients with osteogenesis imperfecta.
authors.affiliation: Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan. gwatanab@sapmed.ac.jp
authors.forename: Goichi
authors.initials: G
authors.lastname: Watanabe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawaguchi
authors.forename: Toshikatsu
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamashita
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D015519:Bone Density; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007738:Kyphosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D007870:Leg Length Inequality / Q000209:etiology / Q000503:physiopathology; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D010013:Osteogenesis Imperfecta / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011859:Radiography; D018570:Risk Assessment; D012307:Risk Factors; D012600:Scoliosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D012720:Severity of Illness Index; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging