title: Root surface biomodification with EDTA for the treatment of gingival recession with a semilunar coronally repositioned flap.
abstract: BACKGROUND
  The purpose of this randomized clinical trial was to evaluate the outcome of gingival recession therapy using the semilunar coronally repositioned flap (SCRF) with or without EDTA application for root surface biomodification.
  
  
  METHODS
  Fifteen patients with bilateral Miller Class I buccal gingival recessions (< or =4.0 mm) were selected. Thirty teeth with recessions were assigned randomly to receive the semilunar coronally repositioned flap with (SCRF-E group) or without (SCRF group) the application of an EDTA gel. Recession height (RH), recession width (RW), width (WKT) and thickness of keratinized tissue, probing depth, and clinical attachment level (CAL) were measured at baseline and 6 months post-surgery. Patient perception of root sensitivity and postoperative pain also was evaluated.
  
  
  RESULTS
  Both treatments yielded significant improvements in terms of RH and RW decrease and CAL gain compared to baseline values. For SCRF-E and SCRF, the average root coverage was 70.2% and 90.1%, respectively (P = 0.01), and the complete root coverage was 40.0% and 66.7%, respectively. Only the SCRF group had a significant (P <0.05) increase in WKT. The SCRF group showed a greater reduction (P <0.05) in RW and RH compared to the SCRF-E group. No patient in either group reported any pain during the postoperative course; however, 6 months later, patients in the SCRF-E group complained more of residual or new root sensitivity compared to patients in the SCRF group.
  
  
  CONCLUSIONS
  The use of EDTA gel as a root surface biomodifier agent negatively affected the outcome of root coverage with the SCRF.
authors.affiliation: Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Piracicaba, University of Campinas, Piracicaba, SP, Brazil.
authors.forename: Sandro
authors.initials: S
authors.lastname: Bittencourt
authors.forename: Erica Del Peloso
authors.initials: Edel P
authors.lastname: Ribeiro
authors.forename: Enilson Antônio
authors.initials: EA
authors.lastname: Sallum
authors.forename: Antônio Wilson
authors.initials: AW
authors.lastname: Sallum
authors.forename: Francisco Humberto
authors.initials: FH
authors.lastname: Nociti
authors.forename: Márcio Zaffalon
authors.initials: MZ
authors.lastname: Casati
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002614:Chelating Agents / Q000009:adverse effects*; D003807:Dentin Sensitivity / Q000139:chemically induced*; D004492:Edetic Acid / Q000009:adverse effects*; D005260:Female; D005889:Gingival Recession / Q000601:surgery*; D005893:Gingivoplasty / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013524:Surgical Flaps; D014092:Tooth Root / Q000187:drug effects*
chemical_list: D002614:Chelating Agents; D004492:Edetic Acid