title: Relationship between serum soluble E-selectin levels and development of diabetic retinopathy in patients with type 2 diabetes.
abstract: OBJECTIVE
  To investigate whether diabetic retinopathy is associated with serum soluble E-selectin (ssE-selectin) level in type 2 diabetic patients.
  
  
  METHODS
  Fifty-six patients with type 2 diabetes classified as Groups A, B, C and D according to grade of retinopathy were enrolled in the study. Sixteen age- and gender-matched healthy control subjects were also enrolled. Levels of ssE-selectin were measured using enzyme-linked immunosorbent assays (ELISAs) in all patients and control subjects. Clinical characteristics and ssE-selectin levels were compared between the groups.
  
  
  RESULTS
  There was no statistically significant difference in ssE-selectin levels between diabetic patients and non-diabetic control subjects (p>0.05). There was also no statistically significant difference in levels of ss E-selectin between diabetic subgroups (Groups A, B, C, D) (p>0.05). No correlation was found between ssE-selectin level and HbA1c, or duration of diabetes in the whole group of diabetic patients (r = 0.10, p>0.05 and r = -0.12, p>0.05, respectively).
  
  
  CONCLUSIONS
  The study shows that no significant elevation of ssE-selectin occurs in patients with type 2 diabetes in comparison with control subjects. Our results also indicate that there is no statistically significant correlation between ssE-selectin level and the development or grade of diabetic retinopathy.
authors.affiliation: Department of Ophthalmology, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Ersanli
authors.forename: C
authors.initials: C
authors.lastname: Top
authors.forename: O
authors.initials: O
authors.lastname: Oncül
authors.forename: A
authors.initials: A
authors.lastname: Aydin
authors.forename: H
authors.initials: H
authors.lastname: Terekeci
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000473:pathology; D003930:Diabetic Retinopathy / Q000097:blood* / Q000209:etiology / Q000473:pathology; D019040:E-Selectin / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D019040:E-Selectin; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human