title: Pancreaticoduodenectomy in a Latin American country: the transition to a high-volume center.
abstract: OBJECTIVE
  To analyze data in a single institution series of pancreaticoduodenectomies (PD) performed in a 7-year period after the transition to a high-volume center for pancreatic surgery.
  
  
  BACKGROUND
  PD has developed dramatically in the last century. Mortality is minimal yet complications are still frequent (around 40%). There are very few reports of PD in Latin America.
  
  
  METHODS
  Data on all PDs performed by a single surgeon from March 2000 to July 2006 in our institution were collected prospectively.
  
  
  RESULTS
  During the study's time frame 122 PDs were performed; 84% were classical resections. Mean age was 57.9 years. Of the patients, 51% were female. Intraoperative mean values included blood loss 881 ml, operative time 5 h and 35 min, and vein resection in 14 cases. Both ampullary and pancreatic cancer accounted for 34% of cases (42 patients each), 5.7% were distal bile duct and 4% duodenal carcinomas. Benign pathology included chronic pancreatitis, neuroendocrine tumors, cystic lesions, and other miscellaneous tumors. Overall operative mortality was 6.5% in the 7-year period, 2.2% in the later 5 years. There was a total of 75 consecutive PDs without mortality. Of the patients, 41.8% had one or more complications. Mean survival for pancreatic cancer was 22.6 months and ampullary adenocarcinoma was 31.4 months.
  
  
  CONCLUSIONS
  To our knowledge, this is the largest single surgeon series of PD performed in Latin America. It emphasizes the importance of experience and expertise at high-volume centers in developing countries.
authors.affiliation: Surgery Department, National Institute of Medical Sciences and Nutrition Salvador Zubirán, México City, Mexico. carchan@quetzal.innsz.mx
authors.forename: Carlos
authors.initials: C
authors.lastname: Chan
authors.forename: Bernardo
authors.initials: B
authors.lastname: Franssen
authors.forename: Alethia
authors.initials: A
authors.lastname: Rubio
authors.forename: Luis
authors.initials: L
authors.lastname: Uscanga
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016577:Pancreaticoduodenectomy