[A case-control study on genetic polymorphism of CYP17 MspA(1)I and its association with endometrial cancer risk].
OBJECTIVE
To assess whether the polymorphisms of CYP17 MspA(1)I are associated with the susceptibility of endometrial cancer.


METHODS
The allelic discrimination of the CYP17A1 gene polymorphisms were assessed with the ABI PRISM 7900 Sequence Detection Systems using TaqMan genotyping assay. Unconditional logistic regression was applied to assess odds ratio and 95% CI and evaluate the association between different genotypes and endometrial cancer development.


RESULTS
The frequencies of wild-type, heterozygote and homozygote for the CYP17 MspA(1)I in control women in Shanghai were 17.8%, 49.3% and 32.9%, respectively. No significant difference was found in the distribution of various genotypes of CYP17 MspA(1)I between patients and controls. Pregnancy was associated with reduced risk of endometrial cancer in pre-menopausal women with A2 allele, OR = 0.66, 95% CI: 0.44 approximately 0.99. In post-menopausal women with A2 allele, more pregnancies ( > 2) and shorter time of menstruation ( < or = 32 yrs) were associated with reduced risk of endometrial cancer.


CONCLUSIONS
No significant relationship was found between CYP17 MspA(1)I genotypes and endometrial cancer risk.
Gao
Jing
J
Department of Epidemiology, Cancer Institute of Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai 200032, China.
Xiang
Yong-bing
YB
Xu
Wang-hong
WH
Cheng
Jia-rong
JR
Cai
Qiu-yin
QY
Shu
Xiao-ou
XO
Gao
Yu-tang
YT
D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D016889:Endometrial Neoplasms / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*
D013254:Steroid 17-alpha-Hydroxylase