Peptide signals encode protein localization.
Many bacterial proteins are localized to precise intracellular locations, but in most cases the mechanism for encoding localization information is not known. Screening libraries of peptides fused to green fluorescent protein identified sequences that directed the protein to helical structures or to midcell. These peptides indicate that protein localization can be encoded in 20-amino-acid peptides instead of complex protein-protein interactions and raise the possibility that the location of a protein within the cell could be predicted from bioinformatic data.
Russell
Jay H
JH
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 401 Althouse, University Park, PA 16827, USA.
Keiler
Kenneth C
KC
D001426:Bacterial Proteins / Q000235:genetics*; D016935:Caulobacter crescentus / Q000235:genetics; D010455:Peptides / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
D001426:Bacterial Proteins; D010455:Peptides