Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes.
BACKGROUND
The effects of different dietary fatty acids on postprandial lipid metabolism in type 2 diabetic patients are still debated.


OBJECTIVE
To evaluate the effects of monounsaturated (MUFA) vs. saturated fat (SAFA)-rich diets on postprandial lipemia and adipose tissue lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL) in type 2 diabetes.


METHODS
Eleven type 2 diabetic patients followed, in random order, a diet rich in MUFA (SAFA 8%, MUFA 23%) and another rich in SAFA (SAFA 17%, MUFA 15%) for a period of 3 weeks each. At the end of the two diets, a standard fat-rich meal was administered and subcutaneous fat biopsies were performed at fasting and 6h after the test meal.


RESULTS
Neither diet induced significant changes in meal lipid tolerance, except for a faster (at 2h) increase in chylomicron triglycerides and a significant decrease in small VLDL triglyceride incremental area after the MUFA diet (-13.6+/-4.7 mg/dl*6h vs. -2.2+/-3.7 mg/dl*6h, p<0.005) (M+/-SEM). LPL and HSL activities were significantly increased after the MUFA diet.


CONCLUSIONS
A MUFA-rich diet reduces postprandial small VLDL triglycerides in type 2 diabetic patients compared to a SAFA-rich diet, and modifies lipolytic enzymes in adipose tissue.
Rivellese
Angela A
AA
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. rivelles@unina.it
Giacco
Rosalba
R
Annuzzi
Giovanni
G
De Natale
Claudia
C
Patti
Lidia
L
Di Marino
Lucrezia
L
Minerva
Valentina
V
Costabile
Giuseppina
G
Santangelo
Carmela
C
Masella
Roberta
R
Riccardi
Gabriele
G
D000273:Adipose Tissue / Q000201:enzymology; D019540:Area Under Curve; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008049:Lipase / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D019518:Postprandial Period; D002787:Sterol Esterase / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D014280:Triglycerides; D002787:Sterol Esterase; D008049:Lipase; D008071:Lipoprotein Lipase