title: Consumption of organic foods and risk of atopic disease during the first 2 years of life in the Netherlands.
abstract: We prospectively investigated whether organic food consumption by infants was associated with developing atopic manifestations in the first 2 years of life. The KOALA Birth Cohort Study in the Netherlands (n 2764) measured organic food consumption, eczema and wheeze in infants until age 2 years using repeated questionnaires. Diet was defined as conventional ( 90 % organic). Venous blood samples taken from 815 infants at 2 years of age were analysed for total and specific IgE. Multivariate logistic regression models were fitted to control for potential confounding factors. Eczema was present in 32 % of infants, recurrent wheeze in 11 % and prolonged wheezing in 5 %. At 2 years of age, 27 % of children were sensitised against at least one allergen. Of all the children, 10 % had consumed a moderately organic diet and 6 % a strictly organic diet. Consumption of organic dairy products was associated with lower eczema risk (OR 0.64 (95 % CI 0.44, 0.93)), but there was no association of organic meat, fruit, vegetables or eggs, or the proportion of organic products within the total diet with the development of eczema, wheeze or atopic sensitisation. Further studies to substantiate these results are warranted.
authors.affiliation: Department of Epidemiology, Care and Public Health Research Institute (Caphri), Maastricht University, Maastricht, The Netherlands.
authors.forename: Ischa
authors.initials: I
authors.lastname: Kummeling
authors.forename: Carel
authors.initials: C
authors.lastname: Thijs
authors.forename: Machteld
authors.initials: M
authors.lastname: Huber
authors.forename: Lucy P L
authors.initials: LP
authors.lastname: van de Vijver
authors.forename: Bianca E P
authors.initials: BE
authors.lastname: Snijders
authors.forename: John
authors.initials: J
authors.lastname: Penders
authors.forename: Foekje
authors.initials: F
authors.lastname: Stelma
authors.forename: Ronald
authors.initials: R
authors.lastname: van Ree
authors.forename: Piet A
authors.initials: PA
authors.lastname: van den Brandt
authors.forename: Pieter C
authors.initials: PC
authors.lastname: Dagnelie
mesh_terms: D003611:Dairy Products; D004485:Eczema / Q000453:epidemiology / Q000517:prevention & control; D004812:Epidemiologic Methods; D005247:Feeding Behavior; D005260:Female; D058870:Food, Organic / Q000706:statistics & numerical data*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology / Q000517:prevention & control*; D007073:Immunoglobulin E / Q000097:blood; D007225:Infant Food; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D012130:Respiratory Hypersensitivity / Q000453:epidemiology / Q000517:prevention & control; D012135:Respiratory Sounds
chemical_list: D007073:Immunoglobulin E