title: Myotonic response induced by inhibitors of cholesterol biosynthesis.
abstract: Steroid inhibitors of cholesterogenesis containing nitrogen-substituted side chains induced electromyographic myotonia in rats. Cholesterol reduction or desmosterol accumulation, per se, did not cause myotonia, and cholestrol feeding prevented drug-induced myotonia. Desmosterol accumulation in combination with a specific drug effect may cause the observed myotonia.
authors.forename: N
authors.initials: N
authors.lastname: Winer
authors.forename: D M
authors.initials: DM
authors.lastname: Klachko
authors.forename: R D
authors.initials: RD
authors.lastname: Baer
authors.forename: P L
authors.initials: PL
authors.lastname: Langley
authors.forename: T W
authors.initials: TW
authors.lastname: Burns