title: Lesion-induced sprouting in the rat dentate gyrus is inhibited by repeated ethanol administration.
abstract: The effect of ethanol on hippocampal axonal sprouiting was studied with a histochemical technique for identifying acetylcholinesterase. Unilateral lesion of the entorhinal cortex in adult rats produced an increase in the density of acetylcho-linesterase staining in the outer molecular layer and a concomitant increase in the width of the pale-staining commissural-associational zone of the dentate gyrus. Other rats were given ethanol (11.3 +/- 0.45 grams per kilogram) for 2 weeks before and 9 days after receiving the lesion. Ethanol abolished the expansion of the commissural-associational zone. The effect of ethanol on sprouting axons suggests that it may inhibit recovery of function after brain injury.
authors.forename: J R
authors.initials: JR
authors.lastname: West
authors.forename: M D
authors.initials: MD
authors.lastname: Lind
authors.forename: R M
authors.initials: RM
authors.lastname: Demuth
authors.forename: E S
authors.initials: ES
authors.lastname: Parker
authors.forename: R L
authors.initials: RL
authors.lastname: Alkana
authors.forename: M
authors.initials: M
authors.lastname: Cassell
authors.forename: A C
authors.initials: AC
authors.lastname: Black