Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder.
We evaluated plasma levels of DHEA-S and cortisol before and after treating ADHD patients with one of two medications: methylphenidate (n = 12) or bupropion (n = 10). Boys with ADHD (combined type) were evaluated with the Korean ADHD rating scale (K-ARS) and the computerized ADHD diagnostic system (ADS). All assessments were measured at baseline and repeated after 12 weeks. There were significant clinical improvements in both treatment groups as measured by K-ARS and ADS. DHEA-S levels increased from baseline to endpoint, but cortisol levels did not change significantly. This study suggests that both methylphenidate and bupropion increase plasma levels of DHEA-S in boys with ADHD.
Lee
Moon-Soo
MS
Korea University Medical Center, Seoul, Korea.
Yang
Jae-Won
JW
Ko
Young-Hoon
YH
Han
Changsu
C
Kim
Seung-Hyun
SH
Lee
Min-Soo
MS
Joe
Sook-Haeng
SH
Jung
In-Kwa
IK
D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology* / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D015415:Biomarkers / Q000097:blood; D016642:Bupropion / Q000494:pharmacology* / Q000627:therapeutic use; D000697:Central Nervous System Stimulants / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007723:Korea; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D015415:Biomarkers; D000697:Central Nervous System Stimulants; D016642:Bupropion; D008774:Methylphenidate; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone