CRP gene is involved in the regulation of human longevity: a follow-up study in Finnish nonagenarians.
Chronic low-grade inflammation is involved in the pathogenesis of many disease conditions in humans and it is frequently quantified by measuring the blood concentration of C-reactive protein (CRP). Here we show that the CRP concentration in old people (nonagenarians) is, at least partially, genetically determined, and that the high producer genotype is associated with a shorter life expectancy during follow-up. Thus, the data imply that the CRP gene may be a longevity gene in humans.
Hurme
M
M
University of Tampere Medical School, Tampere, Finland. mikko.hurme@uta.fi
Kivimäki
M
M
Pertovaara
M
M
Lehtimäki
T
T
Karhunen
P J
PJ
Jylhä
M
M
Hervonen
A
A
Eklund
C
C
D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis* / Q000235:genetics*; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D006239:Haplotypes; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide
D002097:C-Reactive Protein