Stereochemical control of both C-C and C-N axial chirality in the synthesis of chiral N,O-biaryls.
A Rh(I)-catalyzed asymmetric [2 + 2 + 2] cycloaddition of achiral ynamides is described here. This work demonstrates a unique concept of stereochemical control of both the C-C and C-N axial chirality and provides an approach to the synthesis of chiral N,O-biaryls as well as chiral anilides.
Oppenheimer
Jossian
J
Division of Pharmaceutical Sciences, Department of Chemistry, Rennebohm Hall, 777 Highland Avenue, University of Wisconsin, Madison, Wisconsin 53705, USA.
Hsung
Richard P
RP
Figueroa
Ruth
R
Johnson
Whitney L
WL
D002244:Carbon / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D013237:Stereoisomerism
D002244:Carbon; D009584:Nitrogen