title: Diagnostic accuracy of in-stent coronary restenosis detection with multislice spiral computed tomography: a meta-analysis.
abstract: This study was designed to define the current role of multislice spiral computed tomography (MSCT) for the diagnosis of coronary in-stent restenosis using a meta-analytic process. Restenosis remains a limitation after coronary stent implantation and contributes to a substantial number of coronary re-assessments by conventional invasive coronary angiography (CA). We identified 15 studies (807 patients) evaluating in-stent restenosis by means of both MSCT (>or=16 slices) and conventional CA until February 2007. After data extraction the analysis was performed according to a random-effects model. The analysis pooled the results from 15 studies with a total of 1,175 stents. A substantial number of unassessable stents (13%) were excluded from the analysis underscoring the shortcomings of MSCT. With this major limitation the diagnostic performance of MSCT for in-stent restenosis detection can be summarized as follows: the sensitivity and specificity were 84% [95% confidence interval (CI) 77-89%] and 91% (95% CI 89-93%), respectively, with positive and negative likelihood ratios of 12.2 (95% CI 6.6-22.6) and 0.23 (95% CI 0.17-0.31), respectively, and with a diagnostic odds ratio of 67.9 (95% CI 34.4-134.1). MSCT has shortcomings difficult to overcome in daily practice for in-stent restenosis detection and continues to have moderately high sensitivity and specificity. The diagnostic role of this emerging technology as an alternative to CA for in-stent restenosis detection remains limited.
authors.affiliation: Department of Radiology, University Hospital of Caen, 14033 Caen Cedex, Normandy, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Hamon
authors.forename: Laure
authors.initials: L
authors.lastname: Champ-Rigot
authors.forename: Rémy
authors.initials: R
authors.lastname: Morello
authors.forename: John W
authors.initials: JW
authors.lastname: Riddell
authors.forename: Martial
authors.initials: M
authors.lastname: Hamon
mesh_terms: D017023:Coronary Angiography / Q000379:methods*; D023903:Coronary Restenosis / Q000175:diagnosis*; D006801:Humans; D016017:Odds Ratio; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015607:Stents; D036542:Tomography, Spiral Computed / Q000379:methods*