title: Normal-pressure hydrocephalus: white matter lesions correlate negatively with gait improvement after lumbar puncture.
abstract: OBJECTIVE
  To test relations between white matter lesions (WML) load in Normal Pressure Hydrocephalus (NPH) patients and gait characteristics at baseline, duration of symptoms, gait improvement after lumbar puncture (LP), vascular risk factors.
  
  
  METHODS
  Fifteen idiopathic NPH patients.
  
  
  METHODS
  Patients underwent a timed walking test, before and after LP. Five gait variables were assessed and improvement percentages were calculated. WML load was rated regionally and globally in T2 weighted MRI images, using a simple visual scale. Spearman or Pearson correlation coefficients were used to test relations between variables.
  
  
  RESULTS
  Significant negative correlations were found between WML scores and gait improvement after CSF removal but not with duration of symptoms or gait variables before LP.
  
  
  CONCLUSIONS
  WML seem to contribute to the irreversibility of symptoms in NPH but not to the pathophysiological mechanisms that lead to them.
authors.affiliation: Neurology Department, Hospital Egas Moniz, Rua da Junqueira 126, 1349-019 Lisboa, Portugal. paulobugalho@sapo.pt
authors.forename: Paulo
authors.initials: P
authors.lastname: Bugalho
authors.forename: Luísa
authors.initials: L
authors.lastname: Alves
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020127:Recovery of Function / Q000502:physiology*; D012307:Risk Factors; D013129:Spinal Puncture; D017211:Treatment Failure