title: Post-transcriptional regulation of gene expression in trypanosomes and leishmanias.
abstract: Gene expression in Kinetoplastids is very unusual in that the open reading frames are arranged in long polycistronic arrays, monocistronic mRNAs being created by post-transcriptional processing. Thus the regulation of gene expression is post-transcriptional. We here discuss recent results concerning the enzymes required for mRNA degradation, and components of the translation initiation machinery, and how both are regulated.
authors.affiliation: Zentrum für Molekualre Biologie der Universität Heidelberg, Im Neuenheimer Feld 282, D69120 Heidelberg, Germany. cclayton@zmbh.uni-heidelberg.de
authors.forename: Christine
authors.initials: C
authors.lastname: Clayton
authors.forename: Michal
authors.initials: M
authors.lastname: Shapira
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D007891:Leishmania / Q000235:genetics*; D014176:Protein Biosynthesis; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000378:metabolism; D016053:RNA, Protozoan / Q000378:metabolism; D014345:Trypanosoma / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D016053:RNA, Protozoan