title: On the influence of variation in haemodynamic conditions on the generation and growth of cerebral aneurysms and atherogenesis: a computational model.
abstract: A risk-factor criterion, based on near-wall haemodynamic conditions, for the assessment of vascular pathology risk is developed and tested. This criterion has its foundation on experimentally observed vascular wall responses to oscillatory and swirling wall shear stress patterns and is applied to the results of computational simulations. We test this model on two anatomically accurate vascular segments, where pathologies are either commonplace or have already been developed, i.e. a healthy carotid bifurcation and a cerebral fusiform aneurysm. In the case of the former, the risk-assessment criterion predicts the emergence of atherosclerosis of the same locations that the disease is usually encountered. In the case of the latter, the risk factor shows increased probability for the appearance of secondary, "baby", aneurysms at certain locations.
authors.affiliation: Laboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, ETH Zentrum, HG F 57, CH-8092 Zurich, Switzerland.
authors.forename: I
authors.initials: I
authors.lastname: Chatziprodromou
authors.forename: D
authors.initials: D
authors.lastname: Poulikakos
authors.forename: Y
authors.initials: Y
authors.lastname: Ventikos
mesh_terms: D050197:Atherosclerosis / Q000209:etiology / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002339:Carotid Arteries / Q000503:physiopathology*; D002340:Carotid Artery Diseases / Q000209:etiology / Q000503:physiopathology*; D003198:Computer Simulation; D006801:Humans; D002532:Intracranial Aneurysm / Q000209:etiology / Q000503:physiopathology*; D008955:Models, Cardiovascular; D011673:Pulsatile Flow