Sesquiterpenoids from Bombax malabaricum.
Phytochemical investigation of the chemical constituents of the roots of Bombax malabaricum afforded nine cadinane sesquiterpenoids, including five new compounds (bombamalones A-D, 1-4; bombamaloside, 5), and four known compounds (isohemigossypol-1-methyl ester, 6; 2-O-methylisohemigossylic acid lactone, 7; bombaxquinone B, 8; and lacinilene C, 9). The structures of 1-5 were identified by spectroscopic methods and comparison with literature values. Compounds 1-9 were evaluated against the HGC-27 human gastrointestinal cancer cell line, but all were inactive (IC(50) >10 microM).
Zhang
Xiaohui
X
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Science, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Zhu
Huilin
H
Zhang
Shuwei
S
Yu
Qiang
Q
Xuan
Lijiang
L
D035163:Bombax / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes