title: Differentially expressed genes among motor and prefrontal areas of macaque neocortex.
abstract: In higher primates, the motor-related areas of the neocortex are highly differentiated into several subareas based on both functional and cytoarchitectural aspects. To assess the molecular basis of this areal specialization, we investigated the gene expression profiles of the primary motor area (M1), premotor area (dorsal and ventral, PMd and PMv, respectively), and prefrontal area (A46) in rhesus monkeys using DNA microarray. We discovered that 476 genes were differentially expressed among these 4 areas. More than half of these genes were most abundantly expressed in M1, and most genes were complementarily expressed between M1 and A46. The expression profiles of PMd and PMv were quite similar to each other and different from those of M1 and A46. The data will provide a fundamental basis for the further analysis of the structure-function relationship of the primate brain.
authors.affiliation: Comparative Systems Biology Team, Genomic Sciences Center, RIKEN, Yokohama 230-0045, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Sato
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Takao
authors.initials: T
authors.lastname: Oishi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Higo
authors.forename: Yumi
authors.initials: Y
authors.lastname: Murata
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Onoe
authors.forename: Kimika
authors.initials: K
authors.lastname: Saito
authors.forename: Fumiharu
authors.initials: F
authors.lastname: Tsuboi
authors.forename: Masahito
authors.initials: M
authors.lastname: Takahashi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Isa
authors.forename: Toshio
authors.initials: T
authors.lastname: Kojima
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D001931:Brain Mapping; D016000:Cluster Analysis; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D008251:Macaca; D009044:Motor Cortex / Q000378:metabolism*; D019579:Neocortex / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D017397:Prefrontal Cortex / Q000378:metabolism*