title: FTIR, magnetic, 1H NMR spectral and thermal studies of some chelates of caproic acid: inhibitory effect on different kinds of bacteria.
abstract: A convenient method for the preparation of complexes of the Cr3+, Mn2+, Fe3+, Co2+, Ni2+, Zn2+, ZrO2+, UO2(2+), Zr4+ and Th4+ ions with caproic acid (Hcap) is reported and this has enabled 10 complexes of caproate anion to be formulated: [Cr(cap)3].5H2O, [Mn(cap)2(H2O)2], [Fe(cap)3].12H2O, [Co(cap)2(H2O)2].4H2O, [Ni(cap)2(H2O)2].3H2O, [Zn(cap)2], [ZrO(cap)2].3H2O, [UO2(cap)(NO3)], [Zr(cap)2(Cl)2] and [Th(cap)4]. These new complexes were synthesized and characterized by elemental analysis, molar conductivity, magnetic measurements, spectral methods (mid infrared, 1H NMR and UV-vis spectra) and simultaneous thermal analysis (TG and DTG) techniques. It has been found from the elemental analysis as well as thermal studies that the caproate ligand behaves as bidentate ligand and forming chelates with 1:1 (metal:ligand) stoichiometry for UO2(2+), 1:2 for (Mn2+, Co2+, Ni2+, Zn2+, ZrO2+ and Zr4+), 1:3 stoichiometry for (Cr3+ and Fe3+) and 1:4 for Th4+ caproate complexes, respectively, as bidentate chelating. The molar conductance measurements proved that the caproate complexes are non-electrolytes. The kinetic thermodynamic parameters such as: E*, DeltaH*, DeltaS* and DeltaG* are estimated from the DTG curves. The antibacterial activity of the caproic acid and their complexes was evaluated against some gram positive/negative bacteria.
authors.affiliation: Department of Chemistry, Faculty of Education, Port Said, Suez Canal University, Mohamed Ali Street, Port Said, Egypt. msrefat@yahoo.com
authors.forename: Moamen S
authors.initials: MS
authors.lastname: Refat
authors.forename: Sabry A
authors.initials: SA
authors.lastname: El-Korashy
authors.forename: Deo Nandan
authors.initials: DN
authors.lastname: Kumar
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Ahmed
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002138:Calibration; D002208:Caproates / Q000737:chemistry / Q000378:metabolism*; D002413:Cations, Divalent; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D019216:Metals, Heavy / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D000900:Anti-Bacterial Agents; D002208:Caproates; D002413:Cations, Divalent; D002614:Chelating Agents; D019216:Metals, Heavy; C037652:hexanoic acid