title: Treatment considerations for primary uveal melanoma with choroidal metastasis to the fellow eye.
abstract: We report two cases of primary uveal melanoma with metastatic involvement of the contralateral eye. Two female patients presented with primary choroidal melanoma. In the first case, primary enucleation of the affected eye was performed. Two years later, systemic tumor spread with contralateral choroidal melanoma was detected. A decision for observation of the ocular metastasis was made. In the second case, systemic tumor spread was already evident at time of initial diagnosis of the ocular melanoma. Six months later, a choroidal metastasis was detected in the fellow eye. Again, observation was recommended. In conclusion, systemic spread of primary choroidal melanoma may include a choroidal metastasis to the contralateral eye. Observation of the second affected eye may be prescribed.
authors.affiliation: Jules Stein Eye Institute, Ocular Oncology Center, David Geffen/UCLA School of Medicine, Los Angeles, CA 90095, USA. bourla@jsei.ucla.edu
authors.forename: Dan H
authors.initials: DH
authors.lastname: Bourla
authors.forename: Tara A
authors.initials: TA
authors.lastname: Young
mesh_terms: D000369:Aged, 80 and over; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D015353:Eye Enucleation; D017809:Fatal Outcome; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D008875:Middle Aged; D014463:Ultrasonography; D014604:Uveal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*