title: Gastric emptying is altered with the presence of gastritis.
abstract: Helicobacter pylori infection and gastritis can cause symptoms suggestive of altered gastrointestinal function; however, it is unclear if H. pylori influences gastric motility. This study assessed gastric emptying rates in mouse models of gastritis. Gastritis was induced in C57BL/6 mice via ethanol treatment or via challenge with H. pylori or H. felis. Gastric emptying rates of nutrient and non-nutrient liquids were assessed with the non-invasive (13)C-breath test, and the results were compared to healthy mice. Gastric emptying of the non-nutrient liquid was unaltered with the presence of gastritis; however, gastric emptying of the nutrient liquid was accelerated after a 4-week infection with H. pylori. H. felis infection and ethanol treatment caused a more severe gastritis and disruptions to the normal gastric emptying. Changes to gastric emptying in mouse models of gastritis are associated with the presence of nutrients. Altered gastric emptying may contribute to symptoms commonly reported in humans with gastritis.
authors.affiliation: Gastroenterology Unit, Children, Youth and Women's Health Service, North Adelaide 5006, South Australia. erinsymonds@yahoo.com
authors.forename: Erin L
authors.initials: EL
authors.lastname: Symonds
authors.forename: Cuong D
authors.initials: CD
authors.lastname: Tran
authors.forename: Ross N
authors.initials: RN
authors.lastname: Butler
authors.forename: Taher I
authors.initials: TI
authors.lastname: Omari
mesh_terms: D000818:Animals; D000431:Ethanol; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005756:Gastritis / Q000139:chemically induced / Q000382:microbiology / Q000503:physiopathology*; D016481:Helicobacter Infections / Q000503:physiopathology*; D044922:Helicobacter felis; D016480:Helicobacter pylori; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D000431:Ethanol