title: Synthesis of chlorogenic acid derivatives with promising antifungal activity.
abstract: Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids. Most of the compounds exhibited significant potency against Cryptococcus neoformans and Candida species with low toxicity to brine shrimps. The 4,5-dihydroxyl groups in the quinic acid moiety were necessary for the activity and introduction of a free amino group increased the inhibitory activity against Aspergillus fumigatus.
authors.affiliation: School of Pharmacy, Memorial University of Newfoundland, St John's, NL, Canada.
authors.forename: Chao-Mei
authors.initials: CM
authors.lastname: Ma
authors.forename: Maureen
authors.initials: M
authors.lastname: Kully
authors.forename: Jehangir K
authors.initials: JK
authors.lastname: Khan
authors.forename: Masao
authors.initials: M
authors.lastname: Hattori
authors.forename: Mohsen
authors.initials: M
authors.lastname: Daneshtalab
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D002726:Chlorogenic Acid / Q000031:analogs & derivatives*; D003455:Cryptococcus neoformans / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D002726:Chlorogenic Acid