title: Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B.
abstract: Allergic contact dermatitis, such as in response to poison ivy or poison oak, and chronic low-dose ultraviolet B irradiation can damage the skin. Mast cells produce proinflammatory mediators that are thought to exacerbate these prevalent acquired immune or innate responses. Here we found that, unexpectedly, mast cells substantially limited the pathology associated with these responses, including infiltrates of leukocytes, epidermal hyperplasia and epidermal necrosis. Production of interleukin 10 by mast cells contributed to the anti-inflammatory or immunosuppressive effects of mast cells in these conditions. Our findings identify a previously unrecognized function for mast cells and mast cell-derived interleukin 10 in limiting leukocyte infiltration, inflammation and tissue damage associated with immunological or innate responses that can injure the skin.
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California 94305-5176, USA.
authors.forename: Michele A
authors.initials: MA
authors.lastname: Grimbaldeston
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakae
authors.forename: Janet
authors.initials: J
authors.lastname: Kalesnikoff
authors.forename: Mindy
authors.initials: M
authors.lastname: Tsai
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Galli
mesh_terms: D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000276:immunology / Q000473:pathology*; D005260:Female; D007074:Immunoglobulin G / Q000502:physiology; D016753:Interleukin-10 / Q000502:physiology*; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D017452:Receptors, IgG / Q000502:physiology; D012867:Skin / Q000473:pathology* / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D007074:Immunoglobulin G; D017452:Receptors, IgG; D016753:Interleukin-10