title: Elastomeric surgical sealant for hemostasis of cardiovascular anastomosis under full heparinization.
abstract: OBJECTIVE
  We developed a novel surgical sealant, a viscous diisocyanated prepolymer, applicable to arterial hemostasis. The purpose of this study is to evaluate hemostatic effect of this surgical sealant under heparinized conditions.
  
  
  METHODS
  The effectiveness of this sealant was verified by applying it to the end-to-end anastomosis of canine carotid arteries. Five mongrel dogs were used. After a complete heparinization, the carotid arteries were clamped, divided, and end-to-end anastomoses were performed with four simple interrupted sutures. The sealant was coated on the anastomosis. After 5 min the clamps were removed and the hemostatic effect was evaluated. Three dogs were immediately subjected to macroscopic evaluation. Two dogs were subjected to angiography after 3 months and 16 months, respectively.
  
  
  RESULTS
  No bleeding occurred in any of the anastomoses immediately after the removal of the clamp. Macroscopic finding revealed no leakage of the sealant into the lumen. Carotid angiography revealed patent anastomoses without stenosis.
  
  
  CONCLUSIONS
  A novel surgical sealant exhibited rapid and potent hemostatic effect on a moisturized tissue under full heparinization.
authors.affiliation: Division of Cardiovascular Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Eto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Morita
authors.forename: Masakazu
authors.initials: M
authors.lastname: Sugiura
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Ryuji
authors.initials: R
authors.lastname: Tominaga
authors.forename: Takehisa
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D013504:Cardiovascular Surgical Procedures / Q000379:methods*; D004285:Dogs; D020724:Elastomers; D006470:Hemorrhage / Q000517:prevention & control; D006488:Hemostasis, Surgical / Q000379:methods*; D023421:Models, Animal; D011108:Polymers / Q000592:standards*; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D014014:Tissue Adhesives / Q000592:standards*
chemical_list: D020724:Elastomers; D011108:Polymers; D014014:Tissue Adhesives; C036925:elastomeric polymer