title: Rapid simultaneous determination of 14 sulfonamides in wastewater by liquid chromatography tandem mass spectrometry.
abstract: This paper describes a rapid method for the determination of 14 kinds of sulfonamides (SAs) in wastewater using SPE, and LC-MS/MS with positive ESI (ESI(+)) and selected reaction monitoring (SRM) mode. The SPE was performed on an Oasis hydrophilic-lipophilic-balanced (HLB) cartridge. Chromatographic separation on a C18 column was achieved using a binary eluent containing methanol and water with 0.2% formic acid. Typical recoveries of the analytes ranged from 22.3 to 87.0% at a fortification level of 100 ng/L. The LODs in wastewater except sulfathiazole (3 ng/L) could be detected and quantified at levels as low as 1 ng/L. Finally, the method was applied to water from the municipal outlet and the aquaculture wastewater effluent. Sulfamethazine (SM(2)), sulfamethoxypyridazine (SMP), and sulfamethoxazole (SMZ) were most frequently found in wastewater in a concentration range between 1.2 and 31.7 ng/L.
authors.affiliation: Coastal Ecology Key Laboratory of State Oceanic Administration, National Marine Environmental Monitoring Center, Dalian, China.
authors.forename: Sai
authors.initials: S
authors.lastname: Ye
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Yao
authors.forename: Guangshui
authors.initials: G
authors.lastname: Na
authors.forename: Juying
authors.initials: J
authors.lastname: Wang
authors.forename: Deyi
authors.initials: D
authors.lastname: Ma
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002845:Chromatography / Q000379:methods; D002853:Chromatography, Liquid / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D008956:Models, Chemical; D012044:Regression Analysis; D015203:Reproducibility of Results; D052616:Solid Phase Extraction / Q000379:methods; D013418:Sulfamethazine / Q000032:analysis; D013421:Sulfamethoxypyridazine / Q000032:analysis; D013997:Time Factors; D014867:Water; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D014874:Water Pollutants, Chemical; D014867:Water; D013418:Sulfamethazine; D013421:Sulfamethoxypyridazine