[3+2] cycloaddition reactions of cyclopropyl imines with enones.
A nickel-catalyzed [3+2] cycloaddition of cyclopropyl aldimines and enones has been developed. The process provides direct access to trisubstituted cyclopentanes, and the scope exceeds that of the corresponding reactions involving cyclopropyl ketones. A basis for the improved performance of cyclopropyl aldimines compared with cyclopropyl ketones is provided.
Liu
Lei
L
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
Montgomery
John
J