Elevated serum levels of interferon- gamma -inducible protein-10 in patients coinfected with hepatitis C virus and HIV.
Coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is associated with an accelerated course of HCV infection and a faster progression to severe liver disease. We have investigated whether the development of liver disease in coinfected patients is associated with specific chemokine and cytokine production. Four cohorts--HCV/HIV-coinfected patients, HCV-monoinfected patients, HIV-monoinfected patients, and healthy control subjects--were studied. Serum levels of the 10-kDa interferon- gamma -inducible protein (IP-10) were higher in all 3 groups of infected patients than in control subjects (P<.0001). HCV/HIV-coinfected patients had significantly higher IP-10 levels than monoinfected patients. In HCV-monoinfected patients, liver fibrosis scores and liver enzyme levels were positively correlated with IP-10 levels. Elevated IP-10 levels are associated with and may contribute to liver damage in both HCV-monoinfected and HCV/HIV-coinfected patients.
Roe
Barbara
B
Centre for Research in Infectious Diseases, University College Dublin, Dublin, Ireland.
Coughlan
Suzie
S
Hassan
Jaythoon
J
Grogan
Anne
A
Farrell
Gillian
G
Norris
Suzanne
S
Bergin
Colm
C
Hall
William W
WW
D000328:Adult; D054357:Chemokine CXCL10; D018925:Chemokines / Q000097:blood; D019743:Chemokines, CXC / Q000097:blood*; D016207:Cytokines / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D015497:HIV-1; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology / Q000821:virology; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008103:Liver Cirrhosis / Q000276:immunology* / Q000503:physiopathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D015854:Up-Regulation
D054357:Chemokine CXCL10; D018925:Chemokines; D019743:Chemokines, CXC; D016207:Cytokines; D007371:Interferon-gamma