title: [Hormone replacement Up-to-date. Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis].
abstract: Raloxifen is a selective estrogen receptor modulator (SERM) which is used for the treatment of osteoporosis. The major mechanism of action is the suppression of bone resorption. Evidences for the increase of bone mineral density and the decrease of vertebral fractures have been confirmed, while the effects on non-vertebral fractures may need more evidences. There is no doubt for that this drug is one of the major medicines for osteoporosis. On the other hand, extra-skeletal effects including those on cardiovascular systems should be studied further.
authors.affiliation: National Center for Geriatrics and Gerontology, Department of Advanced Medicine, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hosoi
mesh_terms: D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use*; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*
chemical_list: D020845:Selective Estrogen Receptor Modulators; D020849:Raloxifene Hydrochloride