title: [Meta-analysis on the relationship between IL8-251 gene polymorphism and gastric cancer].
abstract: OBJECTIVE
  To evaluate the relationship between IL8-251 gene polymorphisms and gastric cancer.
  
  
  METHODS
  Literatures were reviewed and selected based on the criteria for inclusion. The Meta-analysis software, REVMAN 4.2, was applied to check the heterogeneity across the studies and calculating the pooled OR.
  
  
  RESULTS
  Total of 2114 cases and 2505 controls from 8 studies for IL8-251 were included. The chi(2) value was 21.48 (P = 0.003), and the pooled OR of (AA + AT) vs. TT was 1.12 (95% CI 0.90 - 1.40). Large heterogeneity was found among the studies. After the sensitivity analysis, the pooled OR of (AA + AT) vs. TT 1.21 (95% CI 1.06 - 1.39).
  
  
  CONCLUSIONS
  IL8-251-A allele might be associated with higher risk of developing gastric cancer.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Zi-Dun
authors.initials: ZD
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Shen
authors.forename: Yao-Chu
authors.initials: YC
authors.lastname: Xu
mesh_terms: D000483:Alleles; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D016209:Interleukin-8