Autologous myoblasts and fibroblasts for female stress incontinence: a 1-year follow-up in 123 patients.
OBJECTIVE
To assess the efficacy and safety of the application of autologous myoblasts and fibroblasts for treating female stress urinary incontinence (SUI) after a follow-up of >/=1 year.


METHODS
In all, 123 women with SUI (aged 36-84 years) were treated with transurethral ultrasonography-guided injections with autologous myoblasts and fibroblasts obtained from skeletal muscle biopsies. The fibroblasts were suspended in a small amount of collagen as carrier material and injected into the urethral submucosa, while the myoblasts were implanted into the rhabdosphincter. All patients were evaluated before and 12 months after the injection using the Incontinence and Quality of Life Instrument (I-QOL) scores, urodynamic variables, and morphology and function of the urethra and rhabdosphincter.


RESULTS
At 1 year after implanting the cells, 94 of the 119 women (79%) were completely continent, 16 (13%) had a substantial improvement and nine (8%) a slight improvement. Four patients were lost to follow-up. The incontinence and I-QOL scores, and the thickness, contractility and electromyographic activity of the rhabdosphincter were significantly improved after treatment.


CONCLUSIONS
These results show the efficacy and safety of transferring autologous myoblasts and fibroblasts in the treatment of female SUI, after a follow-up of 1 year.
Mitterberger
Michael
M
Department of Urology, University of Innsbruck, Austria. michael.mitterberger@uibk.ac.at
Marksteiner
Rainer
R
Margreiter
Eva
E
Pinggera
Germar M
GM
Colleselli
Daniela
D
Frauscher
Ferdinand
F
Ulmer
Hanno
H
Fussenegger
Martin
M
Bartsch
Georg
G
Strasser
Hannes
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005347:Fibroblasts / Q000637:transplantation*; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008875:Middle Aged; D032446:Myoblasts / Q000637:transplantation*; D011788:Quality of Life; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014463:Ultrasonography; D014550:Urinary Incontinence, Stress / Q000000981:diagnostic imaging / Q000628:therapy*; D014563:Urodynamics