Fate of the two-component lantibiotic lacticin 3147 in the gastrointestinal tract.
The component peptides of lacticin 3147 were degraded by alpha-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, and no lacticin 3147 activity was found in the feces. These observations suggest that lacticin 3147 ingestion is unlikely to have adverse effects, since it is probably inactivated during intestinal transit.
Gardiner
Gillian E
GE
Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland.
Rea
Mary C
MC
O'Riordan
Brid
B
O'Connor
Paula
P
Morgan
Sheila M
SM
Lawlor
Peadar G
PG
Lynch
P Brendan
PB
Cronin
Michael
M
Ross
R Paul
RP
Hill
Colin
C
D001430:Bacteriocins / Q000378:metabolism*; D002918:Chymotrypsin / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism*
D001430:Bacteriocins; C082508:lacticin 481; D002918:Chymotrypsin; C117608:alpha-chymotrypsin