title: Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus, in patients infected with HCV subtype 1b.
abstract: We conducted a retrospective study of 65 patients with chronic hepatitis C, to determine whether the secondary structure of the amino-terminal 120 residues of the hepatitis C virus (HCV) NS3 protein is associated with an increased risk of development of hepatocellular carcinoma (HCC). The cumulative incidence of HCC was highest among patients infected with group B HCV-1b, wherein the risk of HCC significantly increased compared with that among patients infected with group A (hazard ratio, 4.95 [95% CI, 1.43-17.11]) after adjustment for age and histological stage. This HCV-1b grouping may be a useful marker for detecting the risk of development of HCC.
authors.affiliation: Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata 990-9585, Japan. ynishise-gi@umin.ac.jp
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nishise
authors.forename: Takafumi
authors.initials: T
authors.lastname: Saito
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sugahara
authors.forename: Jun-Itsu
authors.initials: JI
authors.lastname: Ito
authors.forename: Koji
authors.initials: K
authors.lastname: Saito
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Togashi
authors.forename: Motoko
authors.initials: M
authors.lastname: Nagano-Fujii
authors.forename: Hak
authors.initials: H
authors.lastname: Hotta
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000821:virology*; D005260:Female; D016174:Hepacivirus / Q000145:classification* / Q000235:genetics / Q000472:pathogenicity; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D017433:Protein Structure, Secondary; D012307:Risk Factors; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000235:genetics; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases