Bioactive ent-clerodane diterpenoids from Scutellaria barbata.
Four new ENT-clerodane diterpenoids were isolated from the whole plant of Scutellaria barbata D. Don. (Labiatae). Their structures were elucidated by chemical methods and spectral analyses. in vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range 3.1-7.2 microM.
Dai
Sheng-Jun
SJ
School of Pharmaceutical Science, Yantai University, Yantai, People's Republic of China. daishengjun_9@hotmail.com
Sun
Jing-Yong
JY
Ren
Yan
Y
Liu
Ke
K
Shen
Li
L
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D045785:Diterpenes, Clerodane / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D035261:Plant Components, Aerial; D031363:Scutellaria
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045785:Diterpenes, Clerodane