Severe, obstructive biventricular hypertrophy in a patient with Costello syndrome: Clinical impact and management.
We report a severe, biventricular obstructive cardiomyopathy in a young female with Costello syndrome, who underwent a right ventricular myectomy for symptoms relief. We discuss potential clinical implications and management of severe hypertrophy in Costello syndrome.
Limongelli
Giuseppe
G
Pacileo
Giuseppe
G
Digilio
Maria Cristina
MC
Calabro'
Paolo
P
Di Salvo
Giovanni
G
Rea
Alessandra
A
Miele
Tiziana
T
Frigiola
Alessandro
A
Sarkozy
Anna
A
Dallapiccola
Bruno
B
Marino
Bruno
B
Calabro'
Raffaele
R
D000015:Abnormalities, Multiple / Q000235:genetics / Q000473:pathology*; D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics / Q000473:pathology; D010641:Phenotype; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics; D012720:Severity of Illness Index; D013577:Syndrome
D000319:Adrenergic beta-Antagonists; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)