title: A comparison of polysomnographic and actigraphic evaluation of periodic limb movements in sleep.
abstract: OBJECTIVE
  As a standard method, periodic limb movements in sleep (PLMS) are detected by means of polysomnography (PSG). Actigraphic detection of PLMS is a recently developed method for performing of multiple-night recordings in an outpatient setting. The aim of our study was to assess sensitivity-related parameters of actigraphic detection of PLMS in comparison to the PSG, when mounted at ankles and at the base of the big toe.
  
  
  METHODS
  We simultaneously performed PSG and actigraphic recordings at both ankles and at the bases of both big toes (Cambridge Actiwatch AW-64) for 40 nights. The PLM index (PLMI), number of periodic movements per hour of sleep, was the primary output of both methods.
  
  
  RESULTS
  We have proven significant correlation of all resulting parameters when comparing actigraphy at either position to the PSG; however, the PLMI values obtained by the actigraphy at toes were significantly higher than by PSG (sign test, p<0.0001). At bases of the big toes, threshold of PLMI=7.6 was used as a cut off for positivity, while PLMI=5 at ankles was used for PSG. Comparing ankle versus toe actigraphic placement, sensitivity was 67% versus 94%, specificity was 95% versus 91% and negative predictive value was 78% versus 95%. The correlation of the results from actigraphy and PSG was not affected by presence of respiratory events.
  
  
  CONCLUSIONS
  Our results suggest good validity of actigraphic PLM evaluation at the base of big toe using AW-64 devices and therefore, actigraphy seems suitable for screening purposes in both clinical and research usage.
authors.affiliation: Department of Neurology, General Teaching Hospital and First Medical Faculty, Charles University, Prague, Czech. kemlink@volny.cz
authors.forename: David
authors.initials: D
authors.lastname: Kemlink
authors.forename: Martin
authors.initials: M
authors.lastname: Pretl
authors.forename: Karel
authors.initials: K
authors.lastname: Sonka
authors.forename: Sona
authors.initials: S
authors.lastname: Nevsimalova
mesh_terms: D000328:Adult; D004576:Electromyography; D001330:Electronic Data Processing; D005260:Female; D006801:Humans; D007866:Leg / Q000294:innervation*; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D020189:Nocturnal Myoclonus Syndrome / Q000503:physiopathology*; D017286:Polysomnography / Q000379:methods*; D012016:Reference Values; D012044:Regression Analysis; D012680:Sensitivity and Specificity