title: Fate of the two-component lantibiotic lacticin 3147 in the gastrointestinal tract.
abstract: The component peptides of lacticin 3147 were degraded by alpha-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, and no lacticin 3147 activity was found in the feces. These observations suggest that lacticin 3147 ingestion is unlikely to have adverse effects, since it is probably inactivated during intestinal transit.
authors.affiliation: Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland.
authors.forename: Gillian E
authors.initials: GE
authors.lastname: Gardiner
authors.forename: Mary C
authors.initials: MC
authors.lastname: Rea
authors.forename: Brid
authors.initials: B
authors.lastname: O'Riordan
authors.forename: Paula
authors.initials: P
authors.lastname: O'Connor
authors.forename: Sheila M
authors.initials: SM
authors.lastname: Morgan
authors.forename: Peadar G
authors.initials: PG
authors.lastname: Lawlor
authors.forename: P Brendan
authors.initials: PB
authors.lastname: Lynch
authors.forename: Michael
authors.initials: M
authors.lastname: Cronin
authors.forename: R Paul
authors.initials: RP
authors.lastname: Ross
authors.forename: Colin
authors.initials: C
authors.lastname: Hill
mesh_terms: D001430:Bacteriocins / Q000378:metabolism*; D002918:Chymotrypsin / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism*
chemical_list: D001430:Bacteriocins; C082508:lacticin 481; D002918:Chymotrypsin; C117608:alpha-chymotrypsin