title: Host single-nucleotide polymorphisms and altered responses to inactivated influenza vaccine.
abstract: We analyzed the relationship between host gene polymorphisms and responses in recipients of inactivated influenza vaccine, who were classified into poor, normal, or adverse response groups. The frequency of the mannose-binding lectin-2 codon 54 allele was significantly different among the 3 types of responders, with a decreased odds ratio for the development of poor or adverse responses (P=.033). There was no statistical relationship between responses and either tumor necrosis factor- alpha or interleukin (IL)-10 promoter polymorphisms among the 3 response groups. When poor and normal responses were combined, the -1082 A allele in the IL-10 promoter conferred a significantly decreased risk of the development of adverse responses (P=.041). These data indicate that host polymorphisms play a role in determining responses to influenza vaccine.
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. yiwei.tang@vanderbilt.edu
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Tang
authors.forename: Haijing
authors.initials: H
authors.lastname: Li
authors.forename: Huiyun
authors.initials: H
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Shyr
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Edwards
mesh_terms: D000483:Alleles; D003062:Codon; D005091:Exons; D005787:Gene Frequency; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology; D009981:Influenza B virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D016753:Interleukin-10 / Q000235:genetics; D037601:Mannose-Binding Lectin / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D003062:Codon; D007252:Influenza Vaccines; D037601:Mannose-Binding Lectin; D014409:Tumor Necrosis Factor-alpha; D015164:Vaccines, Inactivated; D016753:Interleukin-10