IL-10-producing type 1 regulatory T cells and allergy.
As an important subset of regulatory T (Treg) cells, IL-10-producing type 1 regulatory T cells (Tr1), have some different features to thymic-derived naturally occurring CD4+CD25+Foxp3+ Treg cells(nTreg cells). Similar to nTreg cells, Tr1 also play important roles in the control of allergic inflammation in several ways. There is a fine balance between Tr1 and Th2 responses in healthy subjects. Skewing of allergic-specific effector T cells to a Tr1 phenotype appears to be a critical event in successful allergen-specific immunotherapy and glucocorticoids and beta2-agonists treatment. Tr1 suppress Th2 cells and effector cells of allergic inflammation, such as eosinophils, mast cells, basophils, through producing IL-10, and perhaps TGF-beta. Understanding of Tr1 may be helpful in developing new strategies for treatment of allergic diseases.
Wu
Kui
K
Department of Respiratory Disease, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Bi
Yutian
Y
Sun
Kun
K
Wang
Changzheng
C
D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007167:Immunotherapy; D016753:Interleukin-10 / Q000096:biosynthesis*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism*
D016753:Interleukin-10