title: Experimental validation of the new nanodosimetry-based cell survival model for mixed neutron and gamma-ray irradiation.
abstract: The new nanodosimetry-based linear-quadratic (LQ) formula has been reviewed for mixed-LET irradiation. V-79 Chinese hamster cells have been irradiated with a mixed-LET field of fission neutrons and gamma rays at the University of Maryland Training Reactor (MUTR). The results show that the experimental survival curve agrees well with that predicted by the new nanodosimetry-based LQ model. The experimental study described in this note, therefore, serves as a validation for the new model to be used for mixed-LET radiotherapies, e.g. 252Cf brachytherapy.
authors.affiliation: Nuclear/Radiological Engineering/Medical Physics Program Neely Research Center, Georgia Institute of Technology, 900 Atlantic Drive, Atlanta, GA 30332-0425, USA. chris.wang@nre.gatech.edu
authors.forename: C-K Chris
authors.initials: CK
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Ian
authors.initials: I
authors.lastname: Gifford
authors.forename: Eric
authors.initials: E
authors.lastname: Burgett
authors.forename: Vince
authors.initials: V
authors.lastname: Adams
authors.forename: Mohamad
authors.initials: M
authors.lastname: Al-Sheikhly
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000379:methods*; D002470:Cell Survival / Q000528:radiation effects*; D003198:Computer Simulation; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008954:Models, Biological; D036103:Nanotechnology / Q000379:methods*; D009502:Neutrons; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*