title: [The associations of serum gastrin level with Helicobacter pylori infection].
abstract: OBJECTIVE
  To investigate the associations of serum gastrin-17 (G-17) concentration with helicobacter pylori (Hp) infection.
  
  
  METHODS
  A (13)C-urea breath and ELISA test to determine the Helicobacter pylori status and to detect the serum gastrin concentration was conducted in 242 villagers in Linqu of Shandong Province, a high gastric cancer prevalence area in China.
  
  
  RESULTS
  Of 242 subjects, 65 of 111 were found Hp-positive in males (58.56%), compared with 65 of 131 in females (49.62%) (chi(2) = 1.932, P = 0.165). The statistical difference was not observed among different age groups (chi(2) = 4.185, P = 0.123). The average level of G-17 among 242 subjects was (24.43 +/- 25.46) pmol/L and it was statistically higher in females (29.87 +/- 28.18) pmol/L than that in males (18.01 +/- 20.11) pmol/L (Z = -3.618, P < 0.001). However, there was no statistical difference found among age groups (chi(2) = 1.948, P = 0.378). The G-17 level in Hp-negative group (35.50 +/- 30.92) pmol/L was observed significantly higher than in Hp-positive group (14.90 +/- 13.79) pmol/L (Z = 5.368, P = 0.0001).
  
  
  CONCLUSIONS
  The G-17 concentration was found higher in Hp-negative subjects than in Hp-positive subjects, and higher in female than in male, but no difference was found among age groups.
authors.affiliation: Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing 100036, China.
authors.forename: Xiao-Rui
authors.initials: XR
authors.lastname: Nie
authors.forename: Tong
authors.initials: T
authors.lastname: Zhou
authors.forename: Kai-Feng
authors.initials: KF
authors.lastname: Pan
authors.forename: Wen-Qing
authors.initials: WQ
authors.lastname: Li
authors.forename: Guo-Shuang
authors.initials: GS
authors.lastname: Feng
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
authors.forename: Wei-Cheng
authors.initials: WC
authors.lastname: You
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D005755:Gastrins / Q000097:blood*; D016481:Helicobacter Infections / Q000097:blood* / Q000453:epidemiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012424:Rural Population; D012494:Sampling Studies
chemical_list: D005755:Gastrins; C013550:gastrin 17