title: Expression of functional toll-like receptors by B-chronic lymphocytic leukemia cells.
abstract: This study reports that B-chronic lymphocytic leukemia (B-CLL) cells display the same pattern of toll-like receptors (TLRs) proteins expression as normal B-cells, yet with overexpression of TLR9. Furthermore, TLR7 and TLR9 appear to be functional and liable to respond to specific ligands, respectively imidazoquinolines and CpG-ODN thus potentially opening new therapeutic approaches.
authors.forename: Cindy
authors.initials: C
authors.lastname: Grandjenette
authors.forename: Anne
authors.initials: A
authors.lastname: Kennel
authors.forename: Gilbert C
authors.initials: GC
authors.lastname: Faure
authors.forename: Marie C
authors.initials: MC
authors.lastname: Béné
authors.forename: Pierre
authors.initials: P
authors.lastname: Feugier
mesh_terms: D017209:Apoptosis; D049109:Cell Proliferation; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D051217:Toll-Like Receptor 9 / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism*
chemical_list: C408982:CPG-oligonucleotide; D007093:Imidazoles; D009838:Oligodeoxyribonucleotides; D011804:Quinolines; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D051217:Toll-Like Receptor 9; D051193:Toll-Like Receptors