title: The PhenoGen informatics website: tools for analyses of complex traits.
abstract: BACKGROUND
  With the advent of "omics" (e.g. genomics, transcriptomics, proteomics and phenomics), studies can produce enormous amounts of data. Managing this diverse data and integrating with other biological data are major challenges for the bioinformatics community. Comprehensive new tools are needed to store, integrate and analyze the data efficiently.
  
  
  METHODS
  The PhenoGen Informatics website http://phenogen.uchsc.edu is a comprehensive toolbox for storing, analyzing and integrating microarray data and related genotype and phenotype data. The site is particularly suited for combining QTL and microarray data to search for "candidate" genes contributing to complex traits. In addition, the site allows, if desired by the investigators, sharing of the data. Investigators can conduct "in-silico" microarray experiments using their own and/or "shared" data.
  
  
  CONCLUSIONS
  The PhenoGen website provides access to tools that can be used for high-throughput data storage, analyses and interpretation of the results. Some of the advantages of the architecture of the website are that, in the future, the present set of tools can be adapted for the analyses of any type of high-throughput "omics" data, and that access to new tools, available in the public domain or developed at PhenoGen, can be easily provided.
authors.affiliation: Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA. sanjiv.bhave@uchsc.edu
authors.forename: Sanjiv V
authors.initials: SV
authors.lastname: Bhave
authors.forename: Cheryl
authors.initials: C
authors.lastname: Hornbaker
authors.forename: Tzu L
authors.initials: TL
authors.lastname: Phang
authors.forename: Laura
authors.initials: L
authors.lastname: Saba
authors.forename: Razvan
authors.initials: R
authors.lastname: Lapadat
authors.forename: Katherina
authors.initials: K
authors.lastname: Kechris
authors.forename: Jeanette
authors.initials: J
authors.lastname: Gaydos
authors.forename: Daniel
authors.initials: D
authors.lastname: McGoldrick
authors.forename: Andrew
authors.initials: A
authors.lastname: Dolbey
authors.forename: Sonia
authors.initials: S
authors.lastname: Leach
authors.forename: Brian
authors.initials: B
authors.lastname: Soriano
authors.forename: Allison
authors.initials: A
authors.lastname: Ellington
authors.forename: Eric
authors.initials: E
authors.lastname: Ellington
authors.forename: Kendra
authors.initials: K
authors.lastname: Jones
authors.forename: Jonathan
authors.initials: J
authors.lastname: Mangion
authors.forename: John K
authors.initials: JK
authors.lastname: Belknap
authors.forename: Robert W
authors.initials: RW
authors.lastname: Williams
authors.forename: Lawrence E
authors.initials: LE
authors.lastname: Hunter
authors.forename: Paula L
authors.initials: PL
authors.lastname: Hoffman
authors.forename: Boris
authors.initials: B
authors.lastname: Tabakoff
mesh_terms: D003628:Database Management Systems; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D023281:Genomics; D020407:Internet; D040641:Quantitative Trait Loci