[The associations of serum gastrin level with Helicobacter pylori infection].
OBJECTIVE
To investigate the associations of serum gastrin-17 (G-17) concentration with helicobacter pylori (Hp) infection.


METHODS
A (13)C-urea breath and ELISA test to determine the Helicobacter pylori status and to detect the serum gastrin concentration was conducted in 242 villagers in Linqu of Shandong Province, a high gastric cancer prevalence area in China.


RESULTS
Of 242 subjects, 65 of 111 were found Hp-positive in males (58.56%), compared with 65 of 131 in females (49.62%) (chi(2) = 1.932, P = 0.165). The statistical difference was not observed among different age groups (chi(2) = 4.185, P = 0.123). The average level of G-17 among 242 subjects was (24.43 +/- 25.46) pmol/L and it was statistically higher in females (29.87 +/- 28.18) pmol/L than that in males (18.01 +/- 20.11) pmol/L (Z = -3.618, P < 0.001). However, there was no statistical difference found among age groups (chi(2) = 1.948, P = 0.378). The G-17 level in Hp-negative group (35.50 +/- 30.92) pmol/L was observed significantly higher than in Hp-positive group (14.90 +/- 13.79) pmol/L (Z = 5.368, P = 0.0001).


CONCLUSIONS
The G-17 concentration was found higher in Hp-negative subjects than in Hp-positive subjects, and higher in female than in male, but no difference was found among age groups.
Nie
Xiao-Rui
XR
Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing 100036, China.
Zhou
Tong
T
Pan
Kai-Feng
KF
Li
Wen-Qing
WQ
Feng
Guo-Shuang
GS
Zhang
Yang
Y
Zhang
Lian
L
You
Wei-Cheng
WC
D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D005755:Gastrins / Q000097:blood*; D016481:Helicobacter Infections / Q000097:blood* / Q000453:epidemiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012424:Rural Population; D012494:Sampling Studies
D005755:Gastrins; C013550:gastrin 17