Expression of functional toll-like receptors by B-chronic lymphocytic leukemia cells.
This study reports that B-chronic lymphocytic leukemia (B-CLL) cells display the same pattern of toll-like receptors (TLRs) proteins expression as normal B-cells, yet with overexpression of TLR9. Furthermore, TLR7 and TLR9 appear to be functional and liable to respond to specific ligands, respectively imidazoquinolines and CpG-ODN thus potentially opening new therapeutic approaches.
Grandjenette
Cindy
C
Kennel
Anne
A
Faure
Gilbert C
GC
Béné
Marie C
MC
Feugier
Pierre
P
D017209:Apoptosis; D049109:Cell Proliferation; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D051217:Toll-Like Receptor 9 / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism*
C408982:CPG-oligonucleotide; D007093:Imidazoles; D009838:Oligodeoxyribonucleotides; D011804:Quinolines; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D051217:Toll-Like Receptor 9; D051193:Toll-Like Receptors