title: Effect of prophylactic brimonidine instillation on bleeding during strabismus surgery in adults.
abstract: OBJECTIVE
  To investigate the effects of preoperative brimonidine-purite 0.15% instillation on intraoperative bleeding and postoperative subconjunctival hemorrhage during strabismus surgery in adult patients.
  
  
  METHODS
  Randomized comparative interventional case series.
  
  
  METHODS
  One hundred and eighteen eyes of 90 consecutive adult patients were instilled with either a single drop of brimonidine-purite 0.15% (42 eyes), phenylephrine 1% (38 eyes), or sodium hyaluronate 0.1% (38 eyes) 15 minutes prior to strabismus surgery. Intraoperative bleeding and postoperative subconjunctival hemorrhage were graded on a scale of one to three. The scores were compared among the study groups.
  
  
  RESULTS
  Scores of the intraoperative bleeding and the postoperative subconjunctival hemorrhage of the treatment groups were significantly less than that of the control group (P < .001). The scores of the brimonidine group were similar to those of the phenylephrine group (intraoperative bleeding score, P = .405; subconjunctival hemorrhage score, P = .722).
  
  
  CONCLUSIONS
  Topical brimonidine administration before strabismus surgery may reduce intraoperative bleeding and postoperative subconjunctival hemorrhage in adult patients.
authors.affiliation: Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Samin
authors.initials: S
authors.lastname: Hong
authors.forename: Chan Yun
authors.initials: CY
authors.lastname: Kim
authors.forename: Gong Je
authors.initials: GJ
authors.lastname: Seong
authors.forename: Sueng-Han
authors.initials: SH
authors.lastname: Han
mesh_terms: D000287:Administration, Topical; D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D000068438:Brimonidine Tartrate; D003229:Conjunctival Diseases / Q000517:prevention & control*; D004311:Double-Blind Method; D005130:Eye Hemorrhage / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage; D008297:Male; D009801:Oculomotor Muscles / Q000601:surgery; D010656:Phenylephrine / Q000008:administration & dosage; D011292:Premedication; D011810:Quinoxalines / Q000627:therapeutic use*; D013285:Strabismus / Q000601:surgery
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D011810:Quinoxalines; D010656:Phenylephrine; D000068438:Brimonidine Tartrate; D006820:Hyaluronic Acid