Hypothermia as a treatment for birth asphyxia.
This chapter will report to the frequency of neonatal hypoxic-ischemic encephalopathy. The pathophysiology and the childhood outcome of encephalopathy due to hypoxia-ischemia will be examined. The limitations of current therapy for this condition and new therapies will be evaluated. Hypothermia seems to offer the most promise as a therapy for neuroprotection in hypoxic-ischemic encephalopathy. The evidence-based trials of hypothermia will be reviewed along with recommendations regarding clinical applications for this therapy and need for long-term follow-up of children receiving this therapy.
Shankaran
Seetha
S
Wayne State University, Children's Hospital of Michigan, Detroit, MI 48201, USA. sshankar@med.wayne.edu
Laptook
Abbot R
AR
D001238:Asphyxia Neonatorum / Q000150:complications / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D011379:Prognosis; D016896:Treatment Outcome