Fatal post-traumatic zygomycosis in an immunocompetent young patient.
Zygomycosis, a relatively uncommon infection, usually occurs among immunocompromised individuals. It has been reported only rarely in trauma patients. A fatal case is reported of pulmonary and rapidly progressive cutaneous zygomycosis in a young, otherwise healthy farmer, with multiple bone fractures, wounds and soft tissue injuries after an accident with an agricultural machine in the field. Rhizopus spp. was isolated from both cultures of bronchial washings and wound samples. The diagnosis was confirmed by histopathological examination of tissue specimens from a large wound. Despite systemic antifungal therapy and surgical debridement, the patient's condition deteriorated and he died from refractory septic shock.
Kontogiorgi
Marina
M
Critical Care Department, Medical School of Athens University, Evangelismos Hospital, Athens, Greece.
Floros
Ioannis
I
Critical Care Department, Medical School of Athens University, Evangelismos Hospital, Athens, Greece.
Koroneos
Apostolos
A
Critical Care Department, Medical School of Athens University, Evangelismos Hospital, Athens, Greece.
Vamvouka
Chrysanthi
C
Department of Pathology, Evangelismos Hospital, Athens, Greece.
Paniara
Olga
O
Department of Clinical Microbiology, Evangelismos Hospital, Athens, Greece.
Roussos
Charis
C
Critical Care Department, Medical School of Athens University, Evangelismos Hospital, Athens, Greece.
Routsi
Christina
C
Critical Care Department, Medical School of Athens University, Evangelismos Hospital, Athens, Greece.
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D012233:Rhizopus / Q000302:isolation & purification*; D012772:Shock, Septic; D014947:Wounds and Injuries / Q000150:complications* / Q000382:microbiology; D020096:Zygomycosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery
D000935:Antifungal Agents