title: [Clinical and pathologic features of melanocytic lesion of the central nervous system].
abstract: OBJECTIVE
  To investigate the clinical and pathologic features of melanocytic lesion of the central nervous system.
  
  
  METHODS
  We analyzed the clinical features, neuroimages, and operational and neuropathological findings of 2 patients of neurocutaneous melanosis and 4 patients of primary leptomeningeal melanoma.
  
  
  RESULTS
  All the 6 patients had the common clinical features of intracranial hypertension and epilepsy. Brain CT and MRI showed abnormal signals. More melanin pigment nevi were found on the skin of the 2 patients subjected to neurocutaneous melanosis. The other 4 patients subjected to primary leptomeningeal melanoma had no melanin pigment nevus on the skin, but the brain section displayed positive meningeal melanoma.
  
  
  CONCLUSIONS
  Intracranial hypertension and epilepsy are the main clinical manifestations of melanocytic lesion of the central nervous system, and cutaneous lesion and radiological findings are very important for the diagnosis.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. zhnxyyy@vip.sina.com
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Zun-Jing
authors.initials: ZJ
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Xiao
authors.forename: Yun-Hai
authors.initials: YH
authors.lastname: Liu
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Li
authors.forename: Bing-Qing
authors.initials: BQ
authors.lastname: Lu
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Liang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008548:Melanosis / Q000473:pathology*; D008577:Meningeal Neoplasms / Q000473:pathology; D008875:Middle Aged; D009422:Nervous System Diseases / Q000473:pathology*; D020752:Neurocutaneous Syndromes / Q000473:pathology*; D055815:Young Adult