Increased circulating CD31+/CD42- microparticles are associated with impaired systemic artery elasticity in healthy subjects.
BACKGROUND
Impaired artery elasticity has been found in various pathological conditions related to endothelial dysfunction. Recently, CD31+/CD42- microparticles (MPs) emerged as a marker of endothelial injury. Whether CD31+/CD42- MPs, generated under physiological conditions, are correlated with artery properties has not been reported.


METHODS
We evaluated brachia-ankle pulse-wave velocity (baPWV) (n = 76) and C1 large-artery and C2 small-artery elasticity indices (n = 56), using noninvasive devices for pulse-wave analysis in a group of healthy persons. The number of circulating CD31+/CD427- MPs (n = 76) was measured by flow cytometric analysis.


RESULTS
Circulating CD31+/CD42- MPs were positively correlated with values of baPWV (r = 0.371, P = .008) and with C1 large-artery and C2 small-artery elasticity indices (r = -0.294, P = .037; and r = -0.310, P = .027, respectively). Multivariate analysis identified CD31+/CD42- MPs as potent contributors to the development of impaired systemic artery elasticity.


CONCLUSIONS
The level of circulating CD31+/CD42- MPs, an important biomarker of dysfunctional endothelium and vascular injury, is closely associated with impaired systemic artery elasticity in healthy subjects. The present study suggests that CD31+/CD42- MPs may be a novel surrogate marker for the clinical evaluation of vascular damage.
Wang
Jie-Mei
JM
Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Huang
Yi-Jun
YJ
Wang
Yan
Y
Xu
Ming-Guo
MG
Wang
Li-Chung
LC
Wang
Shen-Ming
SM
Tao
Jun
J
D000328:Adult; D000368:Aged; D001158:Arteries / Q000502:physiology*; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D004548:Elasticity; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000097:blood*; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000032:analysis*
D015415:Biomarkers; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019038:Platelet Glycoprotein GPIb-IX Complex