title: Interaction study of paracetamol with saturated (capric) and unsaturated (oleic) fatty acids.
abstract: Interaction study of paracetamol with saturated and unsaturated fatty acids, namely, capric and oleic acid have been performed by using serial dilution method, release behavior, FT-IR, and DSC study. Preliminary investigations by release studies indicated the possibility of interaction between paracetamol and fatty acids. UV-studies failed to detect any interaction between paracetamol and fatty acids. The possibility of hydrogen bonding between amino group of paracetamol and carbonyl group of fatty acids was revealed by FT-IR study. Polymorphic transition of paracetamol in the binary sample of paracetamol-capric acid was identified by DSC studies. However, no such possibility was detected in paracetamol-oleic acid mixture.
authors.affiliation: Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, India. arunudps@rediffmail.com
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Misra
authors.forename: Manju
authors.initials: M
authors.lastname: Misra
authors.forename: Gopal Madanlal
authors.initials: GM
authors.lastname: Panpalia
authors.forename: Avinash Keshav
authors.initials: AK
authors.lastname: Dorle
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D003652:Decanoic Acids / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D006860:Hydrogen Bonding; D019301:Oleic Acid / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D018712:Analgesics, Non-Narcotic; D003652:Decanoic Acids; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D019301:Oleic Acid; D000082:Acetaminophen; C031071:decanoic acid