title: Absence of pharyngeal shedding of vaccinia following smallpox vaccination.
abstract: To examine oral shedding of vaccinia in volunteers who were recently vaccinated against smallpox, pharyngeal swabs were collected for viral culture between days 3 and 5 and days 6 and 8 after vaccination with diluted Sanofi Pasteur smallpox vaccine. From 102 adult volunteers (48 vaccinia-naive, 54 vaccinia-experienced), vaccinia was not detected in any specimen (0/201, 95% confidence interval, 0-1.8), which suggests a lack of oral shedding of vaccinia after immunization. This supports recommendations that individuals who were recently vaccinated against smallpox do not require placement in airborne or droplet precautions.
authors.affiliation: Division of Infectious Diseases in the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. tom.talbot@vanderbilt.edu
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Talbot
authors.forename: Jody
authors.initials: J
authors.lastname: Peters
authors.forename: Peter F
authors.initials: PF
authors.lastname: Wright
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Edwards
mesh_terms: D000328:Adult; D006801:Humans; D008875:Middle Aged; D010614:Pharynx / Q000821:virology*; D012899:Smallpox / Q000517:prevention & control*; D012900:Smallpox Vaccine / Q000008:administration & dosage*; D013048:Specimen Handling / Q000379:methods; D014611:Vaccination / Q000706:statistics & numerical data*; D014616:Vaccinia virus / Q000302:isolation & purification*; D017201:Virus Shedding
chemical_list: D012900:Smallpox Vaccine