The differential contribution of dopamine D(1) and D (2) receptors to mu-opioidergic immunomodulation.
Activation of mu-opioid receptors (mu-OR) by the highly selective agonist DAGO (100 microg/kg) significantly increased the immune response in CBA mice. This effect of the mu agonist was prevented by prior blockade of dopamine D(2) receptors with haloperidol (2 mg/kg). In contrast, the selective D(1) receptor antagonist SCH 23390 (1 mg/kg) had no effect on the nature of the immune reaction in response to antigen (sheep erythrocytes, 5 x 10(8) cells). However, blockade of both types of dopamine receptor led to the same effect--immunosuppression. These data lead to the suggestion that D(1) and D(2) receptors make different contributions to modulating immunogenesis on activation of mu-OR.
Cheido
M A
MA
State Research Institute of Physiology, Siberian Branch, Russian Academy of Medical Sciences, 4 Timakov Street, 630117 Novosibirsk, Russia.
Idova
G V
GV
D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology*; D001552:Benzazepines / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D017450:Receptors, Opioid, mu / Q000276:immunology*
D000701:Analgesics, Opioid; D001552:Benzazepines; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D006220:Haloperidol