Coping with stress: ATF6alpha takes the stage.
In this issue of Developmental Cell, two groups, Yamamoto et al. and Wu et al., describe the generation of mice with targeted deletion of the ATF6alpha gene. While ATF6alpha is nonessential for embryonic and postnatal development, deletion has a profound effect on the transcriptional program elicited by endoplasmic reticulum stress, revealing a broader than anticipated role for ATF6 in this signaling network.
Bobrovnikova-Marjon
Ekaterina
E
The Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, PA 19104, USA. adiehl@mail.upenn.edu
Diehl
J Alan
JA
D051702:Activating Transcription Factor 6 / Q000737:chemistry / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism; D002470:Cell Survival / Q000235:genetics; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D017353:Gene Deletion; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D008156:Luciferases / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress; D054645:Protein Phosphatase 1; D017434:Protein Structure, Tertiary; D000071701:Regulatory Factor X Transcription Factors; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
D051702:Activating Transcription Factor 6; D000943:Antigens, Differentiation; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C103652:Elf2 protein, mouse; D009687:Nuclear Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D008156:Luciferases; C513256:Ppp1r15a protein, mouse; D054645:Protein Phosphatase 1