title: A new hippocampal model for examining intracerebral hemorrhage-related neuronal death: effects of deferoxamine on hemoglobin-induced neuronal death.
abstract: OBJECTIVE
  There is an urgent need to develop a model in which to study the mechanism of intracerebral hemorrhage-induced neuronal death in vivo.
  
  
  METHODS
  This study was divided into 2 parts: (1) Rats received either an infusion of hemoglobin, ferrous iron, or saline into the right hippocampus; (2) Rats had an infusion of hemoglobin and then were treated with either deferoxamine or vehicle. Rats were killed for hippocampus size, DNA damage, and neuronal death measurements.
  
  
  RESULTS
  Compared with saline, hemoglobin or iron injection caused hippocampal neuronal death. Systemic use of deferoxamine reduced hemoglobin-induced DNA damage, hippocampal neuronal death, and atrophy.
  
  
  CONCLUSIONS
  This article demonstrates a new model and indicates that iron has a key role in hemoglobin-induced neuronal death.
authors.forename: Shuijiang
authors.initials: S
authors.lastname: Song
authors.forename: Ya
authors.initials: Y
authors.lastname: Hua
authors.forename: Richard F
authors.initials: RF
authors.lastname: Keep
authors.forename: Julian T
authors.initials: JT
authors.lastname: Hoff
authors.forename: Guohua
authors.initials: G
authors.lastname: Xi
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000473:pathology; D003676:Deferoxamine / Q000494:pharmacology*; D004195:Disease Models, Animal; D006454:Hemoglobins / Q000633:toxicity; D006624:Hippocampus / Q000473:pathology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017262:Siderophores / Q000494:pharmacology*
chemical_list: D006454:Hemoglobins; D017262:Siderophores; D003676:Deferoxamine