title: Arterial elasticity is associated with endothelial vasodilatory function and asymmetric dimethylarginine level in healthy subjects.
abstract: Arterial stiffening may be linked to the reduced bioactivity of nitric oxide (NO) and increased plasma concentrations of the endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA). The aim of this study was to investigate whether large (C1) and small artery (C2) elasticity is associated with endothelial function index (EFI) and plasma concentration of ADMA. We included 63 healthy subjects, aged 19 to 70 years, in the study. EFI, C1 and C2 were assessed by pulse wave analysis (PWA) and ADMA level was measured using an enzyme-linked immunoassay. Linear regression analysis revealed significant positive correlation between EFI and both C1 and C2 (R = 0.29, p = 0.02; R = 0.38, p = 0.002, respectively). A significant inverse association occurred between ADMA and C1 as well as C2 (R = -0.32, p = 0.03; R = -0.37, p = 0.009, respectively). In multiple regression analysis, C2 was determined by EFI, ADMA, age and BMI, and C1 was correlated with EFI, age and BMI. These findings suggest that endothelial vasodilatory dysfunction and accumulation of ADMA may be important mechanisms underlying reduced arterial elasticity in healthy subjects.
authors.affiliation: Department of Biochemistry, Centre of Molecular and Clinical Medicine, University of Tartu, Tartu, Estonia. jaak.kals@kliinikum.ee
authors.forename: J
authors.initials: J
authors.lastname: Kals
authors.forename: P
authors.initials: P
authors.lastname: Kampus
authors.forename: M
authors.initials: M
authors.lastname: Kals
authors.forename: R
authors.initials: R
authors.lastname: Teesalu
authors.forename: K
authors.initials: K
authors.lastname: Zilmer
authors.forename: A
authors.initials: A
authors.lastname: Pulges
authors.forename: M
authors.initials: M
authors.lastname: Zilmer
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta / Q000502:physiology*; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D001783:Blood Flow Velocity; D001794:Blood Pressure; D004548:Elasticity; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow; D017534:Radial Artery / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*
chemical_list: C487735:dimethylarginine; D001120:Arginine