title: Diastolic dysfunction after an acute myocardial infarction in patients with antecedent hypertension.
abstract: OBJECTIVE
  We sought to assess changes in the left ventricular systolic and diastolic function in patients with antecedent hypertension and an acute myocardial infarction.
  
  
  METHODS
  A group of 38 patients with antecedent hypertension and acute myocardial infarction were compared with an age-matched nonhypertensive control group. There was a 30-day follow-up. Outcome measures were left ventricular volumes and ejection fraction, systolic velocities, and strain. Diastolic function was assessed by mitral inflow combined with tissue velocities of the mitral ring.
  
  
  RESULTS
  Patients with antecedent hypertension did not experience any regression in the E/E' ratio (16.5 +/- 7.5 vs 17.1 +/- 9.0, P = not significant) or increase in the E'/A' ratio (0.76 +/- 0.5 vs 0.84 +/- 0.6, P = not significant) compared with significant improvements in E/E' ratio (18.9 +/- 8.7 vs 12.8 +/- 7.4, P < .01) and E'/A' ratio (0.76 +/- 0.5 vs 1.1 +/- 0.7, P < .01) in the control group. This was found despite similar changes ejection fraction, volumes, and systolic strain.
  
  
  CONCLUSIONS
  Patients with antecedent hypertension have incomplete improvement of the diastolic function compared with control subjects despite comparable left ventricular volumes and ejection fraction after an acute myocardial infarction.
authors.affiliation: Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark. holmark@ki.au.dk
authors.forename: Niels Holmark
authors.initials: NH
authors.lastname: Andersen
authors.forename: Finn Michael
authors.initials: FM
authors.lastname: Karlsen
authors.forename: Jens Christian
authors.initials: JC
authors.lastname: Gerdes
authors.forename: Anne
authors.initials: A
authors.lastname: Kaltoft
authors.forename: Morten
authors.initials: M
authors.lastname: Bøttcher
authors.forename: Erik
authors.initials: E
authors.lastname: Sloth
authors.forename: Leif
authors.initials: L
authors.lastname: Thuesen
authors.forename: Hans Erik
authors.initials: HE
authors.lastname: Bøtker
authors.forename: Steen Hvitfeldt
authors.initials: SH
authors.lastname: Poulsen
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D001795:Blood Pressure Determination; D016022:Case-Control Studies; D017023:Coronary Angiography; D003971:Diastole; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D011336:Probability; D011379:Prognosis; D011877:Radionuclide Imaging / Q000379:methods; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology*; D013599:Systole; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology