title: Frequency of hypoglycaemia during the intravenous glucose tolerance test in overweight children.
abstract: The study aimed to assess the frequency of hypoglycaemia during the insulin-modified, frequently sampled intravenous glucose tolerance test (FSIVGTT) in overweight Hispanic children. The study included 210 children, mean age=11+/-1.7 years, BMI percentile=97.2+/-2.9 who where enrolled in a longitudinal study to explore risk factors for type 2 diabetes. Two fasting blood samples were collected to determine basal glucose and insulin concentrations. At time 0, glucose (0.3 g/kg body weight) was administered intravenously. Eleven blood samples were collected until 180 min post glucose injection. Insulin (0.02 U/kg body weight) was injected intravenously at 20 min. Plasma was analyzed for glucose and insulin and used for the determination of insulin sensitivity. Hypoglycaemia, defined as a plasma glucose<50 mg/dl, was observed in one asymptomatic subject (<0.5% subjects). In addition, only 1.9% of subjects (n=4) had plasma glucose<60 mg/dl at any time during the FSIVGTT. The frequency of hypoglycaemia during the insulin modified FSIVGTT is very low in overweight Hispanic youth.
authors.affiliation: Department of Health Promotion, College of Health Sciences, University of Texas at El Paso, El Paso, TX 79902, USA. mcruz4@utep.edu
authors.forename: Martha L
authors.initials: ML
authors.lastname: Cruz
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Weigensberg
authors.forename: Richard N
authors.initials: RN
authors.lastname: Bergman
authors.forename: Michael I
authors.initials: MI
authors.lastname: Goran
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D005951:Glucose Tolerance Test; D006630:Hispanic or Latino / Q000208:ethnology; D006801:Humans; D007003:Hypoglycemia / Q000453:epidemiology* / Q000208:ethnology / Q000503:physiopathology; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D050177:Overweight / Q000208:ethnology / Q000502:physiology*; D015995:Prevalence
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose