title: Stimulation of anti-melanoma immune effectors via modified tumour cells exhibiting inhibited IGF-I and low CD9.
abstract: Modified melanoma cells (B16-F0.MOD) characterized by inhibited IGF-I, CD9 low but not their wild-type counterparts (B16-F0.WT), IGF-I positive, CD9 high, were shown to be immunogenic for syngeneic hosts. C57BL/6 syngeneic recipients vaccinated with B16-F0.MOD cells developed immune effectors that were observed at the humoral as well as cellular levels. These immune effectors were shown to be capable of controlling in vitro tumour growth and in vivo tumour progression.
authors.affiliation: Laboratoire de Toxicologie, Faculté de Pharmacie, Université René Descartes Paris 5, Paris, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Trabado
authors.forename: Pascale Nguyen
authors.initials: PN
authors.lastname: Van Binh
authors.forename: Chantal
authors.initials: C
authors.lastname: Martin
authors.forename: Christiane
authors.initials: C
authors.lastname: Lafarge-Frayssinet
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Lone
authors.forename: Jerzy
authors.initials: J
authors.lastname: Trojan
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Warnet
authors.forename: Huynh-Thien
authors.initials: HT
authors.lastname: Duc
mesh_terms: D000818:Animals; D000917:Antibody Formation; D015703:Antigens, CD / Q000096:biosynthesis*; D045744:Cell Line, Tumor; D002470:Cell Survival; D005434:Flow Cytometry; D007111:Immunity, Cellular; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D014611:Vaccination
chemical_list: D015703:Antigens, CD; D007334:Insulin-Like Growth Factor I