Participation in cysteinyl leukotrienes and thromboxane A2 in nasal congestion model in Brown Norway rats.
The aim of this study was to investigate the involvement of chemical mediators in a nasal congestion model in Brown Norway (BN) rats. For the above purpose, we studied the effects of pranlukast and zafirlukast (cysteinyl leukotriene (cys-LT) receptor antagonists), seratrodast and ramatroban (thromboxane A(2) (TXA(2)) receptor antagonists) on nasal congestion and sneezing induced by toluene 2, 4-diisocyanate (TDI). All of these drugs suppressed the increase of enhanced pause (Penh), the index of nasal congestion, in both early and late phase responses; however, pranlukast, zafirlukast and seratrodast failed to suppress immediate sneezing caused by TDI challenge. These results indicate that cys-LTs and TXA(2) are responsible for the development of both early and late phase nasal congestion. Moreover, these chemical mediators contribute very little to immediate sneezing in a BN rat model of allergic rhinitis.
Kishi
Yuko
Y
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8530, Japan.
Nakano
Yoshiyuki
Y
Jiang
Shuishi
S
Yatsuzuka
Rie
R
Kamei
Chiaki
C
D000818:Animals; D016227:Benzoquinones / Q000494:pharmacology; D002227:Carbazoles / Q000494:pharmacology; D002867:Chromones / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006538:Heptanoic Acids / Q000494:pharmacology; D007211:Indoles; D015289:Leukotrienes / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000037:antagonists & inhibitors*; D048448:Phenylcarbamates; D051381:Rats; D011914:Rats, Inbred BN; D018077:Receptors, Leukotriene; D044244:Receptors, Thromboxane A2, Prostaglandin H2 / Q000037:antagonists & inhibitors*; D012220:Rhinitis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism*; D012912:Sneezing / Q000187:drug effects; D013449:Sulfonamides / Q000494:pharmacology; D013928:Thromboxane A2 / Q000378:metabolism; D014105:Tosyl Compounds / Q000494:pharmacology
D016227:Benzoquinones; D002227:Carbazoles; D002867:Chromones; D006538:Heptanoic Acids; D007211:Indoles; D015289:Leukotrienes; D008565:Membrane Proteins; D048448:Phenylcarbamates; D018077:Receptors, Leukotriene; D044244:Receptors, Thromboxane A2, Prostaglandin H2; D013449:Sulfonamides; D014105:Tosyl Compounds; C060230:seratrodast; D013928:Thromboxane A2; C083169:leukotriene D4 receptor; C063119:ramatroban; C047681:pranlukast; C062735:zafirlukast