title: [Nondestructive quantitative analysis of Cofrel medicines by improved partial least squares-NIR spectroscopy].
abstract: In the present paper, improved partial least squares (PLS) method was used to parse near infrared (NIR) reflectance spectrum of Cofrel medicine. The contents of benproperine phosphate, a availability pharmaceutical in Cofrel medicine, were accurately nondestructively quantitatively predicted. The best number of principal components (PC) was designed by scores plot of samples in PC. The effects of the wavelength range, conventional spectra, first-derivative spectra and second-derivative spectra on the results were discussed respectively. Comparing the results with those of HPLC, the relative errors(RE%) of benproperine phosphate were less than 0.42%. The analytical results were sufficient for practical manufacture of Cofrel medicine.
authors.affiliation: College of Chemistry, Jilin University, Changchun 130023, China. liumingyangs@sohu.com
authors.forename: Ming-Yang
authors.initials: MY
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Meng
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Ren
authors.forename: Han-Qi
authors.initials: HQ
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D000996:Antitussive Agents / Q000737:chemistry*; D001559:Benzhydryl Compounds / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D016018:Least-Squares Analysis; D010880:Piperidines / Q000737:chemistry*; D025341:Principal Component Analysis; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000996:Antitussive Agents; D001559:Benzhydryl Compounds; D010880:Piperidines; C477447:benproperine