title: Findings of proton magnetic resonance spectometry in the dorsolateral prefrontal cortex in adolescents with first episodes of psychosis.
abstract: Knowledge of the neurobiology of early onset psychosis is limited. We used proton magnetic resonance spectroscopy to investigate the possible existence of dorsolateral prefrontal brain biochemical abnormalities in adolescents with psychosis and to determine possible differential effects related to specific psychotic diagnoses. We measured the ratios of N-acetyl-aspartate (NAA), choline (Cho), and creatine (Cr) to water in two groups of adolescents with a first episode of psychosis (schizophrenia n=8; non-schizophrenia n=15) and in 32 healthy controls matched for age, gender, and years of education. Proton magnetic resonance spectroscopy at 1.5 T was used to study two 6.75-cc voxels placed in the left and right dorsolateral prefrontal region. The schizophrenia patients presented statistically significant reductions in NAA/water levels in the left dorsolateral prefrontal voxel as compared with non-schizophrenia patients and healthy controls. No significant differences were detected between groups for NAA/water in the right dorsolateral prefrontal voxel or for Cho/water and Cr/water levels in any hemisphere. A reduction of the NAA/water level in the left dorsolateral prefrontal region may be selectively present at the onset of psychosis during adolescence in patients who later progress to schizophrenia, but not in those who later progress to other psychotic disorders.
authors.affiliation: Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain. azabala@mce.hggm.es
authors.forename: Arantzazu
authors.initials: A
authors.lastname: Zabala
authors.forename: Javier
authors.initials: J
authors.lastname: Sánchez-González
authors.forename: Mara
authors.initials: M
authors.lastname: Parellada
authors.forename: Dolores María
authors.initials: DM
authors.lastname: Moreno
authors.forename: Santiago
authors.initials: S
authors.lastname: Reig
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Burdalo
authors.forename: Olalla
authors.initials: O
authors.lastname: Robles
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
mesh_terms: D000293:Adolescent; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002648:Child; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D008297:Male; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism*; D011522:Protons; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D011859:Radiography; D014867:Water / Q000378:metabolism
chemical_list: D011522:Protons; D014867:Water; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline