Association study of catechol-O-methyltransferase Val158Met polymorphism with personality traits in Japanese healthy volunteers.
Catechol-O-methyltransferase (COMT) is one of the major enzymes for the degradation of catecholamines. It has been suggested that catecholaminergic neurotransmission is involved in characterization of personality. Previous studies on the association between the COMT Val158Met polymorphism and personality traits in healthy subjects have produced inconsistent results. Therefore, the relationship between this polymorphism and personality was re-examined in 478 Japanese healthy volunteers. Personality traits were assessed by the Temperament and Character Inventory (TCI), and the COMT genotypes were determined by a PCR-RFLP method. In total, there were no significant differences among the Val/Val, Val/Met, and Met/Met genotypes in seven TCI dimension scores. Similarly, no significant relationship was found between the COMT genotypes and the TCI dimensions when males and females were analyzed separately. The present study thus suggests that the COMT Val158Met polymorphism is not associated with personality traits in Japanese healthy subjects.
Ishii
Genki
G
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata 990-9585, Japan.
Suzuki
Akihito
A
Oshino
Shingo
S
Shiraishi
Hiroaki
H
Matsumoto
Yoshihiko
Y
Otani
Koichi
K
Goto
Kaoru
K
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002605:Character; D005260:Female; D005838:Genotype; D006304:Health Status; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010554:Personality Disorders / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011795:Surveys and Questionnaires; D013694:Temperament
D002394:Catechol O-Methyltransferase