[Genetics of anxiety disorders. Current clinical and molecular research].
The authors give an overview of the present state of knowledge on the genetics of anxiety disorders. According to ICD-10 or DSM III/IV classification, anxiety disorders comprise panic disorder, generalized anxiety, phobias, and post-traumatic stress disorder. In the context of the conceptual change from psychodynamic anxiety neuroses to complex, multifactorial anxiety disorders, a summary of biological hypotheses of the pathogenesis of anxiety derived from pharmacotherapy, challenge tests, and animal model disorders is provided. The relevant findings from clinical genetic studies (twin and family) and molecular genetic studies (linkage and association) are presented in detail. The most data now available are on panic disorder, though with regard to molecular genetics these are still preliminary. In addition, genetic findings on anxiety as a personality dimension are reviewed, taking into account the present phenotype discussion (category vs dimension). Finally, ethical and therapeutic implications of genetic research on complex, polygenic disorders are discussed.
Domschke
K
K
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Westfälische Wilhelms-Universität, Münster.
Deckert
J
J
D001008:Anxiety Disorders / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D035843:Biomedical Research / Q000639:trends*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015316:Genetic Therapy / Q000639:trends; D006801:Humans; D008957:Models, Genetic; D008959:Models, Neurological; D008967:Molecular Biology / Q000639:trends*