title: [A fatal case of pulmonary non-tuberculous mycobacteriosis with reactive AA amyloidosis].
abstract: We report a very rare fatal case of reactive AA amyloidosis following pulmonary non-tuberculous mycobacteriosis (PNTM). A 61-year-old woman with a history of PNTM since 1992, whose treatment was difficult because of liver dysfunction and drug eruption caused by antibiotics, had been hospitalized due to recurrent pulmonary bacterial infection. She complained of leg edema in January, 2000, and nephrotic syndrome was diagnosed in February. After diarrhea and abdominal pain appeared in March, she was admitted to our hospital with worsening edema, and dizziness on April 28. Despite treatment, she died on May 5, 2000. Autopsy revealed PNTM and diffuse systemic depositions of amyloid A protein in heart, kidney and gastrointestinal tract. PNTM, often resistance to antibacterial agents, is increasing recently. This case suggests that it is necessary to take care of amyloidosis when various systemic symptoms are observed in chronic inflammatory disease.
authors.affiliation: Department of Respiratory Medicine, Hamamatsu Medical Center.
authors.forename: Nariyuki
authors.initials: N
authors.lastname: Shinozuka
authors.forename: Norio
authors.initials: N
authors.lastname: Kasamatsu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Seto
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yasui
authors.forename: Akira
authors.initials: A
authors.lastname: Nakamura
authors.forename: Ikko
authors.initials: I
authors.lastname: Hashizume
mesh_terms: D000686:Amyloidosis / Q000097:blood / Q000209:etiology*; D001172:Arthritis, Rheumatoid / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications*; D008875:Middle Aged; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications*; D009404:Nephrotic Syndrome / Q000150:complications; D000685:Serum Amyloid A Protein / Q000378:metabolism*
chemical_list: D000685:Serum Amyloid A Protein