title: Severe, obstructive biventricular hypertrophy in a patient with Costello syndrome: Clinical impact and management.
abstract: We report a severe, biventricular obstructive cardiomyopathy in a young female with Costello syndrome, who underwent a right ventricular myectomy for symptoms relief. We discuss potential clinical implications and management of severe hypertrophy in Costello syndrome.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Limongelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pacileo
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Digilio
authors.forename: Paolo
authors.initials: P
authors.lastname: Calabro'
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Salvo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rea
authors.forename: Tiziana
authors.initials: T
authors.lastname: Miele
authors.forename: Alessandro
authors.initials: A
authors.lastname: Frigiola
authors.forename: Anna
authors.initials: A
authors.lastname: Sarkozy
authors.forename: Bruno
authors.initials: B
authors.lastname: Dallapiccola
authors.forename: Bruno
authors.initials: B
authors.lastname: Marino
authors.forename: Raffaele
authors.initials: R
authors.lastname: Calabro'
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics / Q000473:pathology*; D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics / Q000473:pathology; D010641:Phenotype; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics; D012720:Severity of Illness Index; D013577:Syndrome
chemical_list: D000319:Adrenergic beta-Antagonists; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)