title: Does chemotherapy prior to liver resection increase the potential for cure in patients with metastatic colorectal cancer? A report from the European Colorectal Metastases Treatment Group.
abstract: Liver resection offers the only chance of cure for patients with advanced colorectal cancer (CRC). Typically, the 5-year survival rates following liver resection range from 25% to 40%. Unfortunately, approximately 85% of patients with stage IV CRC have liver disease which is considered unresectable at presentation. However, the rapid expansion in the use of improved combination therapy regimens has increased the percentage of patients eligible for potentially curative surgery. Despite this, the selection criteria for patients potentially suitable for resection are not well documented and patient management by multidisciplinary teams, although essential, is still evolving. The goal of the European Colorectal Metastases Treatment Group is to establish pan-European guidelines for the treatment of patients with CRC liver metastases that can be adopted more widely by established treatment centres and to develop more accurate staging systems and evaluation criteria.
authors.affiliation: Hôpital Ambroise Paré, CHU Paris Ouest, 92100 Boulogne Cedex, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Nordlinger
authors.forename: Eric
authors.initials: E
authors.lastname: Van Cutsem
authors.forename: Philippe
authors.initials: P
authors.lastname: Rougier
authors.forename: Claus-Henning
authors.initials: CH
authors.lastname: Köhne
authors.forename: Marc
authors.initials: M
authors.lastname: Ychou
authors.forename: Alberto
authors.initials: A
authors.lastname: Sobrero
authors.forename: Rene
authors.initials: R
authors.lastname: Adam
authors.forename: Dag
authors.initials: D
authors.lastname: Arvidsson
authors.forename: Alfredo
authors.initials: A
authors.lastname: Carrato
authors.forename: Vassilis
authors.initials: V
authors.lastname: Georgoulias
authors.forename: Felice
authors.initials: F
authors.lastname: Giuliante
authors.forename: Bengt
authors.initials: B
authors.lastname: Glimelius
authors.forename: Markus
authors.initials: M
authors.lastname: Golling
authors.forename: Thomas
authors.initials: T
authors.lastname: Gruenberger
authors.forename: Josep
authors.initials: J
authors.lastname: Tabernero
authors.forename: Harpreet
authors.initials: H
authors.lastname: Wasan
authors.forename: Graeme
authors.initials: G
authors.lastname: Poston
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D011300:Preoperative Care / Q000379:methods