[Prediction of etiology based on the clinical type of convulsion in the neonatal period].
OBJECTIVE
To determine whether the seizure clinical type is predictive of etiology.


METHODS
This is a prospective study from 9 neonatal and pediatric intensive care units. Neonatal seizures were defined clinically as described by Volpe. The seizures etiology was defined by positive clinical date, cranial sonogram and laboratory investigation routinely obtained in all neonates with seizures. Correlation between seizures type and etiologies was determined by Odds ration (OR).


RESULTS
During one year 89 neonates develop neonatal seizures and the etiologies were determined. The mains seizures types were: subtle (n = 59; 66.3%), tonic (n = 27; 30.4%), clonic (n = 20; 22.4%), myoclonic (n = 4; 4.5%). The most frequent etiologies determined were: asphyxia (n = 60; 67.4%), hypocalcemia (n = 19; 21.3%), hypoglicemia (n = 14; 15.7%), peri-intraventricular hemorrhage (n = 13; 14%). The OR estimate that clonic seizures (OR 5.65 - 1.34 < OR < 23.61%) is predictive to peri-intraventricular hemorrhage.


CONCLUSIONS
The OR estimate high risk to periventricular hemorrhage when the seizure is the clonic type. When the seizure is subtle type the risk is low to this etiology.
de Holanda
Manoel Reginaldo Rocha
MR
Pós-graduando do PPGCSA-UFRN. regisue@terra.com.br
de Melo
Aurea Nogueira
AN
D001238:Asphyxia Neonatorum / Q000150:complications; D001724:Birth Weight; D002543:Cerebral Hemorrhage / Q000150:complications; D016001:Confidence Intervals; D005260:Female; D005865:Gestational Age; D006801:Humans; D006996:Hypocalcemia / Q000150:complications; D007003:Hypoglycemia / Q000150:complications; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D016017:Odds Ratio; D011446:Prospective Studies; D012640:Seizures / Q000145:classification / Q000209:etiology*