NPM1 mutations are more stable than FLT3 mutations during the course of disease in patients with acute myeloid leukemia.
NPM1 mutations have been reported to be the most frequent mutations in acute myeloid leukemia (AML). They are associated with a wide spectrum of morphologic subtypes of AML, normal karyotype and FLT3 mutations. The high frequency of NPM1 mutations might provide a suitable marker for monitoring residual disease of AML.
Palmisano
Michela
M
Grafone
Tiziana
T
Ottaviani
Emanuela
E
Testoni
Nicoletta
N
Baccarani
Michele
M
Martinelli
Giovanni
G
D000208:Acute Disease; D004252:DNA Mutational Analysis; D018450:Disease Progression; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D018365:Neoplasm, Residual / Q000175:diagnosis / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D000090243:Nucleophosmin; D010750:Phosphoproteins / Q000235:genetics; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D010750:Phosphoproteins; D000090243:Nucleophosmin; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3