Effect of a hypocaloric diet in transaminases in nonalcoholic fatty liver disease and obese patients, relation with insulin resistance.
OBJECTIVE
The aim of our study was to examine the changes in hypertransaminasemia after weight reduction in obese patients with and without nonalcoholic fatty liver disease (NAFLD) and the relation with insulin resistance.


METHODS
A population of 142 obesity nondiabetic was treated with a hypocaloric diet (1520 kcal) during 3 months. Patients were classified as group I (control, n=112) when serum (alanine aminotransferase) ALT activity was normal or group II (NAFLD, n=30) when serum ALT activity was greater than the upper limit of normal reference laboratory (>or=43 UI/L).


RESULTS
In control group, body mass index (BMI) (35.3+/-5.6 vs. 33.5+/-5.5: p<0.05), weight (89.6+/-17.2 kg vs. 85.6+/-16.5 kg: p<0.05) and insulin (15+/-7.9 mUI/L vs. 13.1+/-7.4 mUI/L: p<0.05) levels decreased. In NAFLD group, BMI (37.1+/-4.2 vs. 35.1+/-4.6: p<0.05), weight (101+/-22 kg vs. 96.4+/-11.6 kg: p<0.05), insulin (26.8+/-8.9 mUI/L vs. 12.7+/-8.4 mUI/L: p<0.05) and HOMA (3.1+/-1.6 vs. 1.9+/-1.7: p<0.05) decreased. Liver function improved in both groups (ALT; group I 19.9+/-4.6 UI/L vs. 18.3+/-3.9 UI/L: p<0.05 and group II 37.8+/-4.2 UI/L vs. 27.1+/-7.8 UI/L: p<0.05), (aspartate aminotransferase activity, AST) group I 22.1+/-8.2 UI/L vs. 19.9+/-7.1 UI/L: p<0.05 and group II 73.3+/-11.3 UI/L vs. 38.1+/-11.6UI/L: p<0.05).


CONCLUSIONS
We showed that weight reduction secondary to a hypocaloric diet were associated with improvement in hypertransaminasemia and insulin resistance in NAFLD patients.
de Luis
D A
DA
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, Valladolid University, C/Los Perales 16, Simancas 47130, Valladolid, Spain. Dadluis@yahoo.es
Aller
R
R
Izaola
O
O
Sagrado
M Gonzalez
MG
Conde
R
R
Gonzalez
J M
JM
D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D001794:Blood Pressure; D015992:Body Mass Index; D049628:Body Size; D004038:Diet, Reducing; D005234:Fatty Liver / Q000097:blood / Q000178:diet therapy / Q000201:enzymology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood; D009765:Obesity / Q000178:diet therapy / Q000201:enzymology*
D008055:Lipids; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase