title: H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells.
abstract: It is commonly held that the various granzymes (lethal proteases produced by cytotoxic lymphocytes) utilize their different substrate preferences to bring about various forms of target cell death. Although a considerable body of evidence supports this view, it has now become clear that human granzyme H could have evolved a proteolytic specificity that both interferes directly with adenovirus replication and prevents the virus from blocking the potent pro-apoptotic activity of granzyme B.
authors.affiliation: Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew's Place, Melbourne, Victoria 3002, Australia. nigel.waterhouse@petermac.org
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Waterhouse
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Trapani
mesh_terms: D000257:Adenoviridae Infections / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D000260:Adenoviruses, Human / Q000235:genetics / Q000276:immunology*; D000595:Amino Acid Sequence; D000818:Animals; D016923:Cell Death / Q000276:immunology*; D053804:Granzymes / Q000633:toxicity*; D006801:Humans; D008969:Molecular Sequence Data; D014407:Tumor Cells, Cultured; D014779:Virus Replication / Q000276:immunology
chemical_list: C509213:GZMB protein, human; C069434:GZMH protein, human; D053804:Granzymes