The possible role of hyperhomocysteinemia on IVF outcome.
OBJECTIVE
To evaluate the effect of the hyperhomocysteinemia on pregnancy rate, implantation rate and abortion rate after IVF.


METHODS
Data from a total of 48 infertile couples with hyperhomocysteinemia were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes recovery was performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups that received or did not receive therapy (group A and B respectively) to normalize homocysteine plasma level.


RESULTS
Pregnancy rate, implantation rate and abortion rate varied significantly (p<or=0.05) between the two groups. The number and quality of embryos transferred did not differ between the groups.


CONCLUSIONS
The results suggest that hyperhomocysteinemia could affect IVF outcome.
Pacchiarotti
Arianna
A
Obstetric and Gynecology, Policlinico Umberto, La Sapienza University of Rome, Viale Regina Elena, Rome, Italy. arypac@aliceposta.it
Mohamed
Mohamed A
MA
Micara
Giulietta
G
Linari
Antonella
A
Tranquilli
Daniela
D
Espinola
Salomè B
SB
Aragona
Cesare
C
D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D010064:Embryo Implantation; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate