title: Neoadjuvant chemotherapy enables R0 resection of locally advanced rectal cancer in a patient with a previously irradiated pelvis.
abstract: Pre-operative chemoradiation is frequently employed in an attempt to downstage locally advanced rectal cancer which threatens or involves the circumferential resection margin (CRM) on MRI scanning. We present a case where radiotherapy was contraindicated as the patient had previously been irradiated to a radical dose for prostatic adenocarcinoma. Neoadjuvant capecitabine and oxaliplatin were used to downsize the tumour to permit resection with a clear CRM.
authors.affiliation: Cancer Centre, Queen Elizabeth Hospital, Birmingham B15 2TH, UK. psangy@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: Sanghera
authors.forename: K
authors.initials: K
authors.lastname: Ho
authors.forename: T
authors.initials: T
authors.lastname: Muscroft
authors.forename: A
authors.initials: A
authors.lastname: Hartley
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000069287:Capecitabine; D002295:Carcinoma, Transitional Cell / Q000532:radiotherapy; D039021:Colonic Pouches; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil