title: Melanocortin subtype 4 receptor agonists: structure-activity relationships about the 4-alkyl piperidine core.
abstract: SAR about the piperidine core in a series of MC4R agonists is described. A number of alkyl substituents that furnish compounds with good affinity and functional potency are reported.
authors.affiliation: Department of Medicinal Chemistry, Merck & Co., Inc, PO Box, 2000, Rahway, NJ 07065, USA. iyassu_sebhat@merck.com
authors.forename: Iyassu K
authors.initials: IK
authors.lastname: Sebhat
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Lai
authors.forename: Khaled
authors.initials: K
authors.lastname: Barakat
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Ye
authors.forename: Rui
authors.initials: R
authors.lastname: Tang
authors.forename: Rubana N
authors.initials: RN
authors.lastname: Kalyani
authors.forename: Aurawan
authors.initials: A
authors.lastname: Vongs
authors.forename: Tanya
authors.initials: T
authors.lastname: Macneil
authors.forename: David H
authors.initials: DH
authors.lastname: Weinberg
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Cabello
authors.forename: Marta
authors.initials: M
authors.lastname: Maroto
authors.forename: Ana
authors.initials: A
authors.lastname: Teran
authors.forename: Tung M
authors.initials: TM
authors.lastname: Fong
authors.forename: Lex H T
authors.initials: LH
authors.lastname: Van der Ploeg
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Patchett
authors.forename: Ravi P
authors.initials: RP
authors.lastname: Nargund
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000577:Amides / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D044105:Receptor, Melanocortin, Type 4 / Q000819:agonists* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000737:chemistry
chemical_list: D000473:Alkanes; D000577:Amides; D009570:Nitriles; D010880:Piperidines; D044105:Receptor, Melanocortin, Type 4; D013777:Tetrazoles; C045574:1H-tetrazole; C032727:piperidine