title: The cost effectiveness of influenza vaccination for adults aged 50 to 64 years: a model-based analysis for Spain.
abstract: An economic evaluation of reducing the age threshold for routine influenza vaccination in Spain from 65 to 50 years was performed. A probabilistic model was used to compare a policy based on a recommendation to vaccinate all adults aged 50-64 with the existing vaccination policy for that age group, during interpandemic periods. Two perspectives were considered: third-party payer (TPP) and societal. Model inputs were obtained primarily from the published literature and validated through expert opinion. From TPP perspective, incremental cost-effectiveness ratios were estimated at euro14,919 per quality-adjusted life-year (QALY) gained and euro9731 per life-year gained. From societal perspective, the corresponding results were euro4149 per QALY and euro2706 per life-year gained. Extending routine influenza vaccination to people over 50 years of age is likely to be cost-effective.
authors.affiliation: i3 Innovus, Uxbridge, UK. saballea@i3innovus.com
authors.forename: Samuel
authors.initials: S
authors.lastname: Aballéa
authors.forename: Jose Ramón
authors.initials: JR
authors.lastname: De Juanes
authors.forename: Marco
authors.initials: M
authors.lastname: Barbieri
authors.forename: Monique
authors.initials: M
authors.lastname: Martin
authors.forename: Jeremy
authors.initials: J
authors.lastname: Chancellor
authors.forename: Itziar
authors.initials: I
authors.lastname: Oyagüez
authors.forename: Bertrand
authors.initials: B
authors.lastname: Verwee
authors.forename: Nathalie
authors.initials: N
authors.lastname: Largeron
mesh_terms: D003362:Cost-Benefit Analysis; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000191:economics* / Q000276:immunology; D007251:Influenza, Human / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control*; D008875:Middle Aged; D018803:Models, Economic; D019057:Quality-Adjusted Life Years; D013030:Spain / Q000453:epidemiology; D014611:Vaccination / Q000191:economics
chemical_list: D007252:Influenza Vaccines