Gut overgrowth of vancomycin-resistant enterococci (VRE) results in linezolid-resistant mutation in a child with severe congenital neutropenia: a case report.
A child with severe congenital neutropenia was monitored with microbiologic surveillance cultures for 3 years. He had recurrent bacterial infections and carriage of vancomycin-resistant enterococci. Resistance to linezolid emerged in the colonizing vancomycin-resistant enterococci after each course of this antibiotic when enterococci were present in overgrowth in the gut before treatment. The child was successfully treated for his congenital neutropenia by unrelated donor stem cell transplantation.
Verma
Nitin
N
Department of Haematology and Oncology, Royal Liverpool Children's NHS Trust, Alder Hey, Liverpool.
Clarke
Ray W
RW
Bolton-Maggs
Paula H B
PH
van Saene
Hendrik K F
HK
D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D016983:Enterococcus / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D000069349:Linezolid; D009154:Mutation; D009503:Neutropenia / Q000150:complications* / Q000601:surgery; D023303:Oxazolidinones / Q000494:pharmacology / Q000627:therapeutic use*; D011500:Protein Synthesis Inhibitors; D033581:Stem Cell Transplantation; D013290:Streptococcal Infections / Q000150:complications / Q000188:drug therapy*; D014640:Vancomycin / Q000494:pharmacology; D020713:Vancomycin Resistance
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D011500:Protein Synthesis Inhibitors; D014640:Vancomycin; D000069349:Linezolid