title: Room temperature ionic liquid as matrix medium for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography.
abstract: Using new solvent room temperature ionic liquid (IL) matrix media, testing of residual solvents in pharmaceutical preparations with static headspace gas chromatographic (SH-GC), is described. The purpose of this work was to demonstrate the feasibility of IL as diluent, six solvents utilized in synthesis of Adefovir Dipivoxil: acetonitrile, dichloromethane, N-methyl-2-pyrrolidone (NMP), toluene, dimethylformamide (DMF), n-butyl ether were dissolved in IL: 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF(4)). The method of external standard was used for quantitative analysis. Its performance was evaluated and validated: all the RSD were lower than 10%, the limits of detection were all of the ppm level and the method was both accurate and linear. And better sensitivities for the six solvents were gained with [bmim]BF(4) as diluent comparing with DMSO.
authors.affiliation: Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang City, China.
authors.forename: Feng-Hua
authors.initials: FH
authors.lastname: Liu
authors.forename: Ye
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000032:analysis; D053000:Analytic Sample Preparation Methods; D001881:Borates / Q000737:chemistry; D002849:Chromatography, Gas / Q000379:methods*; D004340:Drug Contamination; D007093:Imidazoles / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D063065:Organophosphonates / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012997:Solvents / Q000032:analysis*; D013696:Temperature; D014465:Ultrasonics; D014835:Volatilization
chemical_list: C419324:1-butyl-3-methylimidazolium tetrafluoroborate; D001881:Borates; D007093:Imidazoles; D052578:Ionic Liquids; D063065:Organophosphonates; D004364:Pharmaceutical Preparations; D012997:Solvents; D000225:Adenine; C106812:adefovir dipivoxil