Synthesis of sol-gel mesoporous silica materials providing a slow release of doxorubicin.
Samples of mesoporous base-catalysed silica xerogel materials made by the sol-gel process were impregnated with an anticancer drug--doxorubicin, followed by different times of ageing at room temperature. The effect of ageing time on the physical and structural properties as well as sorption-desorption of the drug was investigated. The obtained results suggest an inverse relationship with a solid density and surface area increasing as the pore size and volume decrease during ageing time. These results also revealed the effect of ageing time on the efficiency of sorption-desorption of the drug. An increase in ageing time results in an increase of the efficiency of drug sorption and a decrease in the rate of drug release.
Prokopowicz
Magdalena
M
Medical Academy of Gdańsk, Division of Physical Chemistry, Poland. mprokop@biology.pl
Przyjazny
Andrzej
A
D000327:Adsorption; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005612:Freeze Drying; D005782:Gels; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D044367:Phase Transition; D011108:Polymers / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013053:Spectrophotometry / Q000379:methods; D013696:Temperature; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D011108:Polymers; D012822:Silicon Dioxide; D004317:Doxorubicin