Diastereoselective synthesis of gamma-lactams by a one-pot, four-component reaction.
A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra- and pentasubstituted gamma-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct.
Wei
Jingqiang
J
Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.
Shaw
Jared T
JT
D000812:Anhydrides / Q000737:chemistry; D007094:Imides / Q000737:chemistry; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D000812:Anhydrides; D007094:Imides; D007769:Lactams