title: Diabetes-specific cardiomyopathy in type 1 diabetes mellitus: no evidence for its occurrence in the era of intensive insulin therapy.
abstract: Aims The incidence of diabetic cardiomyopathy, independent of arterial hypertension (AH) and coronary heart disease (CHD), remains controversial. The present study aimed to determine the influence of type 1 diabetes mellitus (T1DM) of long duration (>10 years) on myocardial function estimated by echocardiography (ECHO) and serum level of N-terminal pro-B type natriuretic peptide (NT-proBNP) in patients without CHD and AH. We also retrospectively investigated the relationship between the structural changes in the hearts of other deceased T1DM patients, and had their myocardial function echocardiographically assessed before death. Methods and results In 185 patients (96 males) with T1DM (mean duration 22.8 years) and 105 non-diabetic control subjects (57 males), detailed ECHO parameters and NT-proBNP were assessed. No significant differences were found between the respective groups. Histological studies of 17 hearts of deceased T1DM patients were carried out and retrospectively compared with their ECHO performed before death. Histological changes were identified, although without the signs of myocardial dysfunction on ECHO prior to death. Conclusion Even the application of echocardiographic, biochemical and morphologic techniques hardly gives sufficient grounds to believe that type 1 diabetes alone may actually precipitate myocardial dysfunction, despite long-term course of the disease and typical histological changes in the myocardium.
authors.affiliation: Department of Coronary Disease, Jagiellonian University School of Medicine, ul. Pradnicka 80, Krakow 31-202, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Konduracka
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gackowski
authors.forename: Pawel
authors.initials: P
authors.lastname: Rostoff
authors.forename: Danuta
authors.initials: D
authors.lastname: Galicka-Latala
authors.forename: Wieslaw
authors.initials: W
authors.lastname: Frasik
authors.forename: Wieslawa
authors.initials: W
authors.lastname: Piwowarska
mesh_terms: D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D009202:Cardiomyopathies / Q000209:etiology* / Q000473:pathology; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000473:pathology; D003925:Diabetic Angiopathies / Q000209:etiology* / Q000473:pathology; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012189:Retrospective Studies; D012737:Sex Factors; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D015415:Biomarkers; D007004:Hypoglycemic Agents; D007328:Insulin; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain