Topical betablocker use can result in inconclusive dobutamine stress echocardiography in patients with glaucoma.
Dobutamine stress echocardiography is a well-established method to assess coronary artery disease, of which sensitivity has been enhanced by adding atropine at the end of the protocol. Individuals with glaucoma, a disease with a high prevalence in patients with cardiac diseases older than 40 years, cannot benefit from the use of atropine as it is contraindicated for this group of patients. Additionally, these individuals are often treated with topical betablockers (eye drops), which can have systemic effects by decreasing cardiac frequency, blood pressure and pulmonary capacity. The aim of our study was to verify whether a possible systemic effect caused by the use of these eye drops, yielding a low chronotropic response, could result in inconclusive dobutamine stress echocardiography in patients with glaucoma.
Cordovil
Adriana
A
Universidade Federal de São Paulo-UNIFESP/EPM, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil. acordovil@cardiol.br
Matos
Fernando Q
FQ
Campos Filho
Orlando
O
Paranhos
Augusto
A
Rodrigues
Ana Clara T
AC
Albernaz
Márcia V
MV
Paola
Angelo A V de
AA
Carvalho
Antonio Carlos C
AC
D000368:Aged; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000009:adverse effects; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000000981:diagnostic imaging; D004280:Dobutamine / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D025401:Echocardiography, Stress; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D012146:Rest
D002316:Cardiotonic Agents; D009883:Ophthalmic Solutions; D004280:Dobutamine