title: Determining the burden of tuberculosis in Eritrea: a new approach.
abstract: OBJECTIVE
  To obtain an estimate of the prevalence of new cases of smear-positive tuberculosis in Eritrea using a new low-cost approach.
  
  
  METHODS
  The study was designed to include a sample of 35,000 people divided between 40 clusters. The clusters were selected by sampling proportional to population size. In each cluster, census data were obtained from eligible individuals. Individuals aged 15 years or more were questioned about cough and its duration and smoking and were asked to provide two samples of sputum (spot and morning) for examination by fluorescence microscopy.
  
  
  RESULTS
  A total of 38,032 individuals were included in the study. Of the 19,197 individuals aged 15 years or more, 18,152 (94.6%) provided at least one sample of sputum. Fifteen individuals fulfilled the case definition, providing a prevalence of new cases of smear-positive tuberculosis of 90 per 100,000 (95% confidence interval, CI, 35-145 per 100,000) individuals aged 15 years or more and 50 per 100,000 (95% CI, 19-80 per 100,000) in the total population.
  
  
  CONCLUSIONS
  The estimated prevalence of new cases of smear-positive tuberculosis obtained from our study is considerably lower than the estimate published by the World Health Organization. The new methodology for surveys to determine the prevalence of tuberculosis that we used is feasible in the field. This methodology should be validated in other countries and compared with other methods for measuring prevalence.
authors.affiliation: National HIV/AIDS & Tuberculosis Control Division, Ministry of Health, Asmara, Eritrea.
authors.forename: Mineab
authors.initials: M
authors.lastname: Sebhatu
authors.forename: Bahlbi
authors.initials: B
authors.lastname: Kiflom
authors.forename: Melles
authors.initials: M
authors.lastname: Seyoum
authors.forename: Nuredin
authors.initials: N
authors.lastname: Kassim
authors.forename: Tesfazion
authors.initials: T
authors.lastname: Negash
authors.forename: Andeberhan
authors.initials: A
authors.lastname: Tesfazion
authors.forename: Martien W
authors.initials: MW
authors.lastname: Borgdorff
authors.forename: Marieke J
authors.initials: MJ
authors.lastname: van der Werf
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D019017:Eritrea / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012107:Research Design; D012737:Sex Factors; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000453:epidemiology*