title: Familial liability to schizophrenia and premorbid adjustment.
abstract: We assessed premorbid functioning during childhood and adolescence in 50 people with schizophrenia from multiply affected families, 39 of their unaffected siblings, 69 people with schizophrenia with no family history of psychosis, 67 of their unaffected siblings and 83 controls. People with schizophrenia had poorer premorbid social and academic adjustment and exhibited a decline between childhood and adolescence compared with controls. Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence. This may represent a familial (presumed genetic) effect.
authors.affiliation: Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. m.walshe@iop.kcl.ac.uk
authors.forename: Muriel
authors.initials: M
authors.lastname: Walshe
authors.forename: Mark
authors.initials: M
authors.lastname: Taylor
authors.forename: Katja
authors.initials: K
authors.lastname: Schulze
authors.forename: Elvira
authors.initials: E
authors.lastname: Bramon
authors.forename: Sophia
authors.initials: S
authors.lastname: Frangou
authors.forename: Daniel
authors.initials: D
authors.lastname: Stahl
authors.forename: Eugenia
authors.initials: E
authors.lastname: Kravariti
authors.forename: Eileen
authors.initials: E
authors.lastname: Daly
authors.forename: Paul
authors.initials: P
authors.lastname: Fearon
authors.forename: Robin M
authors.initials: RM
authors.lastname: Murray
authors.forename: Colm
authors.initials: C
authors.lastname: McDonald
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004522:Educational Status; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D035781:Siblings / Q000523:psychology; D012917:Social Adjustment; D012931:Social Environment