An efficient and practical synthesis of 2,3-epoxyl-1,3-diaryl-1-propanone by combination of phase transfer catalyst and ultrasound irradiation.
Synthesis of 2,3-epoxyl-1,3-diaryl-1-propanone via epoxidation of chalcone with aqueous sodium hypochlorite was carried out in 62-92% yields using benzyldimethyltetradecyl ammonium chloride as phase transfer catalyst under ultrasound irradiation. Compared to the classical method, the advantages of this method are a safer oxidant, mild conditions, no toxic solvent and shorter reaction time.
Li
Ji-Tai
JT
College of Chemistry and Environmental Science, Key Laboratory of Analytical Science and Technology of Hebei Province, Hebei University, Baoding 071002, PR China. Electronic address: lijitai@mail.hbu.edu.cn.
Liu
Xian-Feng
XF
College of Chemistry and Environmental Science, Key Laboratory of Analytical Science and Technology of Hebei Province, Hebei University, Baoding 071002, PR China.
D002384:Catalysis; D047188:Chalcones / Q000138:chemical synthesis*; D002855:Chromatography, Thin Layer; D004852:Epoxy Compounds / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D016877:Oxidants; D012973:Sodium Hypochlorite; D014465:Ultrasonics
D047188:Chalcones; D004852:Epoxy Compounds; D007202:Indicators and Reagents; D016877:Oxidants; D012973:Sodium Hypochlorite