Synthesis of N-alkoxyphthalimides under ultrasound irradiation.
The alkylation of N-hydroxyphthalimide with alkyl halides in the presence of potassium carbonate results N-alkoxyphthalimides in 64-99% yields in DMSO under ultrasound irradiation. Compared with conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction time and higher yields.
Wang
Shu-Xiang
SX
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, PR China. wsx@mail.hbu.edu.cn
Li
Xin-Wei
XW
Li
Ji-Tai
JT
D000098:Acetophenones / Q000737:chemistry; D000438:Alcohols / Q000737:chemistry; D001965:Bromides / Q000737:chemistry; D002254:Carbonates / Q000032:analysis; D002621:Chemistry / Q000379:methods; D002845:Chromatography / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010797:Phthalimides / Q000737:chemistry*; D011188:Potassium / Q000032:analysis; D012822:Silicon Dioxide / Q000737:chemistry; D013696:Temperature; D013997:Time Factors; D014465:Ultrasonics
D000098:Acetophenones; D000438:Alcohols; D001965:Bromides; D002254:Carbonates; D010797:Phthalimides; C059688:alkoxyl radical; C013190:phenacyl bromide; D012822:Silicon Dioxide; C037593:potassium carbonate; D011188:Potassium