title: Functional optical coherence tomography reveals localized layer-specific activations in cat primary visual cortex in vivo.
abstract: Surface neural activity has been widely visualized using optical intrinsic signal imaging (OISI) from various cortical sensory areas. OISI of the cortical surface with a CCD camera gives integrated information across a depth of a few hundred micrometers. We visualize depth-resolved activation patterns of cat primary visual cortex by functional optical coherence tomography (fOCT). A comparison of the depth-integrated results of fOCT maps with the optical intrinsic signal profiles shows fairly good agreement. Our results reveal layer-specific activation patterns and indicate that the activation was not homogeneous.
authors.affiliation: Integrative Neural Systems Lab., Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako Shi, Saitama Ken, Japan. uma@brain.riken.go.jp
authors.forename: Uma Maheswari
authors.initials: UM
authors.lastname: Rajagopalan
authors.forename: Manabu
authors.initials: M
authors.lastname: Tanifuji
mesh_terms: D000818:Animals; D002415:Cats; D004867:Equipment Design; D005074:Evoked Potentials, Visual; D007091:Image Processing, Computer-Assisted; D015233:Models, Statistical; D009474:Neurons / Q000473:pathology; D055095:Optics and Photonics; D010775:Photic Stimulation; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000379:methods*; D014785:Vision, Ocular; D014793:Visual Cortex / Q000378:metabolism / Q000473:pathology*