title: Identification of a novel e8/a4 BCR/ABL fusion transcript in a case of a transformed Sézary syndrome.
abstract: This report deals with a case of Sézary syndrome, a rare peripheral T-cell lymphoproliferative disorder, in which cytogenetic analysis performed during the disease transformation revealed the presence of a t(9;22) (q34;q11.2) translocation. Molecular analyses identified a new transcript, an e8a4 BCR-ABL fusion mRNA which could be responsible for the disease transformation.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Callet-Bauchu
authors.forename: Gilles
authors.initials: G
authors.lastname: Salles
authors.forename: Sophie
authors.initials: S
authors.lastname: Gazzo
authors.forename: Stéphane
authors.initials: S
authors.lastname: Dalle
authors.forename: Françoise
authors.initials: F
authors.lastname: Berger
authors.forename: Sandrine
authors.initials: S
authors.lastname: Hayette
mesh_terms: D000368:Aged; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D012751:Sezary Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D016044:Fusion Proteins, bcr-abl