title: Diffusion-weighted magnetic resonance imaging of the liver in hepatitis B patients with Child-Pugh a cirrhosis.
abstract: The purpose of this study was to test the hypothesis that cirrhotic change of liver in hepatitis B patients observed in Child-Pugh classification based on clinical assessment would be reflected in the apparent diffusion coefficient (ADC) values calculated from diffusion-weighted magnetic resonance (MR) imaging. Twenty-seven patients with hepatitis B Child-Pugh class A cirrhosis and 10 control subjects were referred for measurement values of the liver on a 3.0-T MR unit. The results revealed that ADCs were significantly lower in hepatitis B patients with Child-Pugh class A compared with control subjects (p < 0.01). In conclusion, our preliminary study showed that hepatitis B patients with Child-Pugh class A had reduced ADC values in liver vis-a-vis normal subjects.
authors.affiliation: Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Feng-O
authors.initials: FO
authors.lastname: Hsu
authors.forename: Yen-Yu
authors.initials: YY
authors.lastname: Chiou
authors.forename: Chiao-Yun
authors.initials: CY
authors.lastname: Chen
authors.forename: Gin-Chung
authors.initials: GC
authors.lastname: Liu
authors.forename: Hui-Chen
authors.initials: HC
authors.lastname: Chu
authors.forename: Hui-Cheng
authors.initials: HC
authors.lastname: Liu
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Chu
authors.forename: Jui-Sheng
authors.initials: JS
authors.lastname: Hsu
mesh_terms: D000328:Adult; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies