title: Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome complicated by aneurysmal aortitis.
abstract: "MAGIC syndrome" (Mouth And Genital ulcers with Inflamed Cartilage) has been proposed to describe patients with clinical features of both relapsing polychondritis and Behcet disease. A total of 18 cases have been reported with only 1 case associated with aneurysmal aortitis described in 1997. Herein, we describe a patient with MAGIC syndrome complicated by aneurysmal aortitis requiring cardiothoracic surgery and intensive immunosuppression. Monitoring for the possible development of inflammatory aortic aneurysms should thus be considered in patients with MAGIC syndrome who have persistently elevated serum inflammatory markers. If an aortic aneurysm is detected, cardiothoracic surgical referral is necessary, close monitoring for enlargement is mandatory, and intensification of immunosuppressive therapy should be considered.
authors.affiliation: Department of Clinical Immunology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia. chin_soon_ng@health.qld.gov.au
authors.forename: Chin Soon
authors.initials: CS
authors.lastname: Ng
authors.forename: Patrick
authors.initials: P
authors.lastname: Hogan
authors.forename: Scott
authors.initials: S
authors.lastname: McKenzie
authors.forename: Harry
authors.initials: H
authors.lastname: Gibbs
authors.forename: Geoff
authors.initials: G
authors.lastname: Strutton
authors.forename: Richard
authors.initials: R
authors.lastname: Wong
mesh_terms: D000328:Adult; D001013:Aorta, Thoracic; D001014:Aortic Aneurysm / Q000150:complications* / Q000601:surgery; D001025:Aortitis / Q000150:complications* / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D019226:Oral Ulcer / Q000150:complications / Q000188:drug therapy; D011081:Polychondritis, Relapsing / Q000150:complications* / Q000188:drug therapy; D013577:Syndrome; D014456:Ulcer / Q000150:complications* / Q000188:drug therapy
chemical_list: D007166:Immunosuppressive Agents