title: [Total and specific IgA in colostrum and milk of mothers of Natal-Rio Grande do Norte, Brasil].
abstract: OBJECTIVE
  To determine the concentration of total secretory IgA and evaluate the repertoire of IgA antibodies to enteropathogenic Escherichia coli and Shigella flexneri antigens in colostrums and milk from mothers in Natal, RN.
  
  
  METHODS
  The sample was constituted by 22 healthy clinically women whose babies were born at public hospital in Natal, RN. To determine total secretory IgA a radial immunedifusion tecnique (Mancini et al, 1965), was employed and to detect specific antibodies, immuneenzimatic assays, ELISA was used.
  
  
  RESULTS
  The median values of total secretory IgA concentration presented individual variations with high levels in colostrums samples, decreasing during lactation, it was observed a p < 0.001 among the samples from the first day of lactation, to the thirtieth for total IgA concentration. All the donators present in colostrum and milk specific antibodies to Escherichia coli enteropathogenic (EPEC) and Shigella flexneri with titles higer in colostrum. There was parallel and directional pattern between total IgA and IgA anti-EPEC and Shegella flexneri, during period.
  
  
  CONCLUSIONS
  The concentrations of total SIgA and specific antibodies to enteropathogenic Escherichia coli and Shigella flexneri in colostrums and milk in our study do not differ from others accomplished among populations with the same social and econimic features, stressing the importance of human milk as a protector agent against pathogens.
authors.affiliation: Departamento de Tocoginecologia da UFRN. edilsondiasaraujo@bol.com.br
authors.forename: Edilson Dias
authors.initials: ED
authors.lastname: Araújo
authors.forename: Solange Barros
authors.initials: SB
authors.lastname: Carbonare
authors.forename: Maria Cristina Pignataro Emerenciano
authors.initials: MC
authors.lastname: de Araújo
authors.forename: Patricia
authors.initials: P
authors.lastname: Palmeira
authors.forename: José Araujo
authors.initials: JA
authors.lastname: Amaral
authors.forename: Valéria Soraya de Farias
authors.initials: VS
authors.lastname: Sales
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D001938:Brazil; D001942:Breast Feeding; D003126:Colostrum / Q000276:immunology*; D003968:Diarrhea, Infantile / Q000382:microbiology / Q000517:prevention & control; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000276:immunology*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D007155:Immunologic Factors / Q000032:analysis; D007223:Infant; D007774:Lactation / Q000276:immunology; D008895:Milk, Human / Q000276:immunology*; D011247:Pregnancy; D012763:Shigella flexneri / Q000276:immunology*; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D007071:Immunoglobulin A, Secretory; D007155:Immunologic Factors