Heparan sulfate proteoglycans and their binding proteins in embryo implantation and placentation.
Complex interactions occur among embryonic, placental and maternal tissues during embryo implantation. Many of these interactions are controlled by growth factors, extracellular matrix and cell surface components that share the ability to bind heparan sulfate (HS) polysaccharides. HS is carried by several classes of cell surface and secreted proteins called HS proteoglycan that are expressed in restricted patterns during implantation and placentation. This review will discuss the expression of HS proteoglycans and various HS binding growth factors as well as extracellular matrix components and HS-modifying enzymes that can release HS-bound proteins in the context of implantation and placentation.
Kirn-Safran
Catherine B
CB
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
D'Souza
Sonia S
SS
Carson
Daniel D
DD
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D010064:Embryo Implantation / Q000235:genetics / Q000502:physiology*; D005260:Female; D005966:Glucuronidase / Q000502:physiology; D019812:Heparan Sulfate Proteoglycans / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D010929:Placentation / Q000235:genetics / Q000502:physiology*; D011247:Pregnancy; D011485:Protein Binding; D013429:Sulfatases; D015238:Sulfotransferases / Q000502:physiology; D000099175:Heparanase
D002352:Carrier Proteins; D005966:Glucuronidase; D019812:Heparan Sulfate Proteoglycans; D013429:Sulfatases; D015238:Sulfotransferases; D000099175:Heparanase; C470791:SULF1 protein, human; C470792:SULF2 protein, human