title: External ophthalmoplegia as the presenting feature of systemic amyloidosis.
abstract: BACKGROUND
  Amyloidosis is a multi-system disease characterised by the intracellular deposition of beta-pleated sheets of amyloid. It can involve the eye, orbit and ocular adnexae.
  
  
  METHODS
  We describe a case of a 58-year-old woman presenting to the eye department with external ophthalmoplegia, including the findings of various investigations. The spectrum of ocular amyloidosis is discussed.
  
  
  CONCLUSIONS
  Amyloidosis may be the underlying diagnosis in some cases of external ophthalmoplegia with findings atypical to other systemic disease.
authors.affiliation: Department of Ophthalmology, University Hospitals of Leicester, Leicester, UK.
authors.forename: Kim Son
authors.initials: KS
authors.lastname: Lett
authors.forename: Ameet
authors.initials: A
authors.lastname: Shah
authors.forename: Irene
authors.initials: I
authors.lastname: Gottlob
mesh_terms: D000686:Amyloidosis / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D005403:Fixation, Ocular; D006801:Humans; D008875:Middle Aged; D009886:Ophthalmoplegia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed