[Clinical and pathologic features of melanocytic lesion of the central nervous system].
OBJECTIVE
To investigate the clinical and pathologic features of melanocytic lesion of the central nervous system.


METHODS
We analyzed the clinical features, neuroimages, and operational and neuropathological findings of 2 patients of neurocutaneous melanosis and 4 patients of primary leptomeningeal melanoma.


RESULTS
All the 6 patients had the common clinical features of intracranial hypertension and epilepsy. Brain CT and MRI showed abnormal signals. More melanin pigment nevi were found on the skin of the 2 patients subjected to neurocutaneous melanosis. The other 4 patients subjected to primary leptomeningeal melanoma had no melanin pigment nevus on the skin, but the brain section displayed positive meningeal melanoma.


CONCLUSIONS
Intracranial hypertension and epilepsy are the main clinical manifestations of melanocytic lesion of the central nervous system, and cutaneous lesion and radiological findings are very important for the diagnosis.
Zhang
Ning
N
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. zhnxyyy@vip.sina.com
Liu
Zun-Jing
ZJ
Li
Gang
G
Xiao
Bo
B
Liu
Yun-Hai
YH
Li
Guo-Liang
GL
Lu
Bing-Qing
BQ
Liang
Jing-Hui
JH
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008548:Melanosis / Q000473:pathology*; D008577:Meningeal Neoplasms / Q000473:pathology; D008875:Middle Aged; D009422:Nervous System Diseases / Q000473:pathology*; D020752:Neurocutaneous Syndromes / Q000473:pathology*; D055815:Young Adult