title: The use of light-emitting diode therapy in the treatment of photoaged skin.
abstract: BACKGROUND
  Light-emitting diode (LED) therapy is an increasingly popular methodology for the treatment of sun damage. Combination use of light wavelengths reported to stimulate collagen synthesis and accelerate fibroblast-myofibroblast transformation may display a composite rejuvenative effect.
  
  
  OBJECTIVE
  To clinically assess reduction in sun damage signs following a 5-week course of LED therapy and to assess subject's perception of the treatment.
  
  
  METHODS
  Thirteen subjects with wrinkles or fine lines in the periorbital and nasolabial region and those presenting Glogau scale photodamage grade II-III received nine 20-min duration light treatments using the Omnilux LED system. The treatments combined wavelengths of 633 and 830 nm at fluences of 126 and 66 J/cm(2), respectively. Sun-damage reduction was assessed at 6, 9, and 12 weeks by clinical photography and patient satisfaction scores.
  
  
  RESULTS
  The majority of subjects displayed "moderate" (50%) or "slight" (25%) response to treatment at investigator assessment. Treatment of the periorbital region was reported more effective than the nasolabial region. At 12-week follow-up, 91% of subjects reported improved skin tone, and 82% reported enhanced smoothness of skin in the treatment area.
  
  
  CONCLUSIONS
  Good response to LED therapy has been shown in this modest sample. Larger trials are needed to assess optimum frequency of light treatments and overall treatment time.
authors.affiliation: International Center for Cosmetic Medicine, Sydney, NSW, Australia. fbaez@optusnet.com.au
authors.forename: Fabien
authors.initials: F
authors.lastname: Baez
authors.forename: Laurence R
authors.initials: LR
authors.lastname: Reilly
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques; D005145:Face; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007259:Infrared Rays / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010789:Phototherapy / Q000379:methods*; D012060:Rejuvenation; D015595:Skin Aging; D016896:Treatment Outcome