Allenic and cumulenic lipids.
Nowadays, about 200 natural allenic metabolites, more than 2700 synthetic allenic compounds, and about 1300 cumulenic structures are known. The present review describes research on natural as well as some biological active allenic and cumulenic lipids and related compounds isolated from different sources. Intensive searches for new classes of pharmacologically potent agents produced by living organisms have resulted in the discovery of dozens of such compounds possessing high anticancer, cytotoxic, antibacterial, antiviral, and other activities. Known allenic and cumulenic compounds can be subdivided on several structural classes: fatty acids, hydrocarbons, terpenes, steroids, carotenoids, marine bromoallenes, peptides, aromatic, cumulenic, and miscellaneous compounds. This review emphasizes the role of natural and synthetic allenic and cumulenic lipids and other related compounds as an important source of leads for drug discovery.
Dembitsky
Valery M
VM
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, P.O. Box 12065, Hebrew University, Jerusalem 91120, Israel. dvalery@cc.huji.ac.il
Maoka
Takashi
T
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D002338:Carotenoids / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology*; D008055:Lipids / Q000494:pharmacology; D045792:Norisoprenoids / Q000494:pharmacology; D010944:Plants / Q000737:chemistry; D011453:Prostaglandins / Q000494:pharmacology; D013256:Steroids / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000494:pharmacology; D014280:Triglycerides / Q000494:pharmacology
D000890:Anti-Infective Agents; D005227:Fatty Acids; D008055:Lipids; D045792:Norisoprenoids; D011453:Prostaglandins; D013256:Steroids; D013729:Terpenes; D014280:Triglycerides; D002338:Carotenoids