[Total and specific IgA in colostrum and milk of mothers of Natal-Rio Grande do Norte, Brasil].
OBJECTIVE
To determine the concentration of total secretory IgA and evaluate the repertoire of IgA antibodies to enteropathogenic Escherichia coli and Shigella flexneri antigens in colostrums and milk from mothers in Natal, RN.


METHODS
The sample was constituted by 22 healthy clinically women whose babies were born at public hospital in Natal, RN. To determine total secretory IgA a radial immunedifusion tecnique (Mancini et al, 1965), was employed and to detect specific antibodies, immuneenzimatic assays, ELISA was used.


RESULTS
The median values of total secretory IgA concentration presented individual variations with high levels in colostrums samples, decreasing during lactation, it was observed a p < 0.001 among the samples from the first day of lactation, to the thirtieth for total IgA concentration. All the donators present in colostrum and milk specific antibodies to Escherichia coli enteropathogenic (EPEC) and Shigella flexneri with titles higer in colostrum. There was parallel and directional pattern between total IgA and IgA anti-EPEC and Shegella flexneri, during period.


CONCLUSIONS
The concentrations of total SIgA and specific antibodies to enteropathogenic Escherichia coli and Shigella flexneri in colostrums and milk in our study do not differ from others accomplished among populations with the same social and econimic features, stressing the importance of human milk as a protector agent against pathogens.
Araújo
Edilson Dias
ED
Departamento de Tocoginecologia da UFRN. edilsondiasaraujo@bol.com.br
Carbonare
Solange Barros
SB
de Araújo
Maria Cristina Pignataro Emerenciano
MC
Palmeira
Patricia
P
Amaral
José Araujo
JA
Sales
Valéria Soraya de Farias
VS
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D001938:Brazil; D001942:Breast Feeding; D003126:Colostrum / Q000276:immunology*; D003968:Diarrhea, Infantile / Q000382:microbiology / Q000517:prevention & control; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000276:immunology*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D007155:Immunologic Factors / Q000032:analysis; D007223:Infant; D007774:Lactation / Q000276:immunology; D008895:Milk, Human / Q000276:immunology*; D011247:Pregnancy; D012763:Shigella flexneri / Q000276:immunology*; D013997:Time Factors
D000907:Antibodies, Bacterial; D007071:Immunoglobulin A, Secretory; D007155:Immunologic Factors