title: antiCODE: a natural sense-antisense transcripts database.
abstract: BACKGROUND
  Natural antisense transcripts (NATs) are endogenous RNA molecules that exhibit partial or complete complementarity to other RNAs, and that may contribute to the regulation of molecular functions at various levels. In recent years, large-scale NAT screens in several model organisms have produced much data, but there is no database to assemble all these data. AntiCODE intends to function as an integrated NAT database for this purpose.
  
  
  RESULTS
  This release of antiCODE contains more than 30,000 non-redundant natural sense-antisense transcript pairs from 12 eukaryotic model organisms. In order to provide an integrated NAT research platform, efficient browser, search and Blast functions have been included to enable users to easily access information through parameters such as species, accession number, overlapping patterns, coding potential etc. In addition to the collected information, antiCODE also introduces a simple classification system to facilitate the study of natural antisense transcripts.
  
  
  CONCLUSIONS
  Though a few similar databases also dealing with NATs have appeared lately, antiCODE is the most comprehensive among these, comprising almost all currently detected NAT pairs.
authors.affiliation: Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, CAMS & PUMC, Beijing 100730, China. yinyifei2005@yahoo.com
authors.forename: Yifei
authors.initials: Y
authors.lastname: Yin
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Changning
authors.initials: C
authors.lastname: Liu
authors.forename: Shuguang
authors.initials: S
authors.lastname: Chen
authors.forename: Runsheng
authors.initials: R
authors.lastname: Chen
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhao
mesh_terms: D003062:Codon / Q000235:genetics*; D003628:Database Management Systems; D030541:Databases, Genetic; D016247:Information Storage and Retrieval / Q000379:methods*; D016372:RNA, Antisense / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014584:User-Computer Interface
chemical_list: D003062:Codon; D016372:RNA, Antisense; D014157:Transcription Factors