The spectrum of scleroderma lung disease.
Pulmonary disease is the most common cause of death in patients with systemic sclerosis. This article discusses the variety of ways the lung is affected in systemic sclerosis. These include pulmonary hypertension, interstitial lung disease and other restrictive disorders, obstructive disease, pleural disease, lung cancer, and aspiration. For each manifestation we outline the current knowledge of etiology, risk factors, diagnosis, treatment, and prognosis. We also discuss the current state of lung transplantation in this population.
Highland
Kristin B
KB
Division of Pulmonary Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA. highlakb@musc.edu
Garin
Margaret C
MC
Brown
Kevin K
KK
D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D016040:Lung Transplantation; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000150:complications*