The role of catecholamines in the prolactin release induced by salsolinol.
Salsolinol (1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline) is an endogenous prolactin releasing agent. Its action can be inhibited by another isoquinoline, 1-methyl-3,4-dihydroisoquinoline (1MeDIQ), which has a strong norepinephrine releasing activity. Salsolinol does not alter the dopamine release in median eminence in vitro, providing evidence for the lack of interaction with presynaptic D2 dopamine receptors. At the same time, lack of norepinephrine transporter abolishes salsolinol's action. Salsolinol decreases tissue level of dopamine and increases norepinephrine to dopamine ratio in organs innervated by the sympathetic nervous system indicating a possible decrease of norepinephrine release. Enzymes of catecholamine synthesis and metabolism are probably also not the site of action of salsolinol. In summary, based upon all of these observations a physiologically relevant interplay might exist between the sympatho-neuronal system and the regulation of prolactin release.
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Neuromorphological and Neuroendocrine Laboratory, Department of Human Morphology and Developmental Biology, Hungarian Academy of Sciences and Semmelweis University, Tuzoltó u. 58., Budapest 1094, Hungary. szekacs.daniel@gmail.com
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D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D007546:Isoquinolines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D008473:Median Eminence / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D011388:Prolactin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D017661:Receptors, Presynaptic / Q000187:drug effects / Q000378:metabolism
C486859:1-methyl-3,4-dihydroisoquinoline; D002395:Catecholamines; D007546:Isoquinolines; D017448:Receptors, Dopamine D2; D017661:Receptors, Presynaptic; D011388:Prolactin; C036617:salsolinol; D006916:5-Hydroxytryptophan; D004299:Dopamine beta-Hydroxylase; D004298:Dopamine; D009638:Norepinephrine