title: Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder.
abstract: We evaluated plasma levels of DHEA-S and cortisol before and after treating ADHD patients with one of two medications: methylphenidate (n = 12) or bupropion (n = 10). Boys with ADHD (combined type) were evaluated with the Korean ADHD rating scale (K-ARS) and the computerized ADHD diagnostic system (ADS). All assessments were measured at baseline and repeated after 12 weeks. There were significant clinical improvements in both treatment groups as measured by K-ARS and ADS. DHEA-S levels increased from baseline to endpoint, but cortisol levels did not change significantly. This study suggests that both methylphenidate and bupropion increase plasma levels of DHEA-S in boys with ADHD.
authors.affiliation: Korea University Medical Center, Seoul, Korea.
authors.forename: Moon-Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Yang
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Ko
authors.forename: Changsu
authors.initials: C
authors.lastname: Han
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Sook-Haeng
authors.initials: SH
authors.lastname: Joe
authors.forename: In-Kwa
authors.initials: IK
authors.lastname: Jung
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology* / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D015415:Biomarkers / Q000097:blood; D016642:Bupropion / Q000494:pharmacology* / Q000627:therapeutic use; D000697:Central Nervous System Stimulants / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007723:Korea; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D015415:Biomarkers; D000697:Central Nervous System Stimulants; D016642:Bupropion; D008774:Methylphenidate; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone