title: HLA-B*0749N: the first HLA-B*07 null allele.
abstract: In the present article, we report the identification of the first HLA-B*07 null allele found in a Polish patient awaiting a kidney allograft. A discrepant result obtained between serological typing (HLA-B "blank") and high-resolution molecular typing using PCR-SSP method (HLA-B*070201 allele) suggested the presence of a null allele. Genomic DNA sequencing of the HLA-B*07 allele revealed a single nucleotide substitution at the 3' end of the exon 4 leading to a premature stop codon.
authors.affiliation: Laboratoire d'Histocompatibilité, CHU Brabois, 54511 Vandoeuvre-les-Nancy Cedex, France. p.perrier@chu-nancy.fr
authors.forename: P
authors.initials: P
authors.lastname: Perrier
authors.forename: A
authors.initials: A
authors.lastname: Dormoy
authors.forename: B
authors.initials: B
authors.lastname: Proust
authors.forename: N
authors.initials: N
authors.lastname: Froelich
authors.forename: A
authors.initials: A
authors.lastname: Bastien
mesh_terms: D000328:Adult; D000483:Alleles; D001483:Base Sequence; D015235:HLA-B Antigens / Q000235:genetics*; D015793:HLA-B7 Antigen; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide
chemical_list: D015235:HLA-B Antigens; C425023:HLA-B*07 antigen; D015793:HLA-B7 Antigen