Identification of a novel e8/a4 BCR/ABL fusion transcript in a case of a transformed Sézary syndrome.
This report deals with a case of Sézary syndrome, a rare peripheral T-cell lymphoproliferative disorder, in which cytogenetic analysis performed during the disease transformation revealed the presence of a t(9;22) (q34;q11.2) translocation. Molecular analyses identified a new transcript, an e8a4 BCR-ABL fusion mRNA which could be responsible for the disease transformation.
Callet-Bauchu
Evelyne
E
Salles
Gilles
G
Gazzo
Sophie
S
Dalle
Stéphane
S
Berger
Françoise
F
Hayette
Sandrine
S
D000368:Aged; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D012751:Sezary Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D014178:Translocation, Genetic
D016044:Fusion Proteins, bcr-abl