HLA-A*020115 and HLA-Cw*030203 show new synonymous mutations in exon 4.
Two novel human leukocyte antigen (HLA) class I alleles, A*020115 and Cw*030203, were completely characterized by sequencing-based typing. Both present synonymous new HLA polymorphisms at exon 4. A*020115 shows a single nucleotide change regarding A*02010101 at codon 245 GCG > GCC). In contrast, Cw*030203 differs from Cw*030202 in a point mutation at codon 271 (ACC > ACT).
Balas
A
A
Departamento de Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, 20832 Madrid, Spain. abalas.trans@salud.madrid.org
Bustamante
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L
García-Sánchez
F
F
Vicario
J L
JL
D000483:Alleles; D001483:Base Sequence; D005091:Exons; D015234:HLA-A Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide
D015234:HLA-A Antigens; D015236:HLA-C Antigens