Antagonizing Methuselah to extend life span.
A recent report describes the identification through the use of in vitro selection of a peptide that antagonizes Methuselah signaling in Drosophila in vitro and extends fly life span in vivo.
Alic
Nazif
N
UCL Centre for Research on Ageing, Department of Biology, Darwin Building, University College London, Gower St, London WC1E 6BT, UK.
Partridge
Linda
L
D000818:Animals; D029721:Drosophila Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D004331:Drosophila melanogaster / Q000502:physiology*; D015195:Drug Design; D008024:Ligands; D008136:Longevity / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology*; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors* / Q000737:chemistry
D029721:Drosophila Proteins; D008024:Ligands; D009842:Oligopeptides; D043562:Receptors, G-Protein-Coupled; C092608:arginyl-tryptophyl-arginine; C115381:mth protein, Drosophila