title: Negative correlation between cerebral inorganic phosphate and the volumetric niacin response in male patients with schizophrenia who have seriously and dangerously violently offended: a (31)P magnetic resonance spectroscopy study.
abstract: The aim of the study was to examine the association of arachidonic acid-related signal transduction with cerebral metabolism in patients with schizophrenia who have violently and dangerously offended while psychotic. Cerebral 31-phosphorus magnetic resonance spectroscopy was carried out in 11 male patients with schizophrenia who had violently offended (homicide, attempted murder, or wounding with intent to cause grievous bodily harm) while psychotic. Spectra were obtained from 70 x 70 x 70 mm(3) voxels using an image-selected in vivo spectroscopy pulse sequence. Niacin flush testing results were quantified as the volumetric niacin response. There was a strong, and negative, correlation between the volumetric niacin response and the metabolite concentration of inorganic phosphate expressed as a ratio of the total 31-phosphorus signal (p<0.005). Our results suggest that patients with schizophrenia who have violently offended and have poor phospholipid-related signal transduction may have higher levels of cerebral energy metabolism.
authors.affiliation: MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK.
authors.forename: B K
authors.initials: BK
authors.lastname: Puri
authors.forename: A J
authors.initials: AJ
authors.lastname: Richardson
authors.forename: S J
authors.initials: SJ
authors.lastname: Counsell
authors.forename: P E
authors.initials: PE
authors.lastname: Ward
authors.forename: M G
authors.initials: MG
authors.lastname: Bustos
authors.forename: G
authors.initials: G
authors.lastname: Hamilton
authors.forename: K K
authors.initials: KK
authors.lastname: Bhakoo
authors.forename: I H
authors.initials: IH
authors.lastname: Treasaden
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000737:chemistry* / Q000378:metabolism; D005483:Flushing; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009525:Niacin / Q000378:metabolism*; D010710:Phosphates / Q000737:chemistry / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*; D012882:Skin Tests; D013223:Statistics as Topic; D014754:Violence
chemical_list: D010710:Phosphates; D009525:Niacin