Effects of an integrated yoga program in modulating psychological stress and radiation-induced genotoxic stress in breast cancer patients undergoing radiotherapy.
Effects of an integrated yoga program in modulating perceived stress levels, anxiety, as well as depression levels and radiation-induced DNA damage were studied in 68 breast cancer patients undergoing radiotherapy. Two psychological questionnaires--Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS)--and DNA damage assay were used in the study. There was a significant decrease in the HADS scores in the yoga intervention group, whereas the control group displayed an increase in these scores. Mean PSS was decreased in the yoga group, whereas the control group did not show any change pre- and postradiotherapy. Radiation-induced DNA damage was significantly elevated in both the yoga and control groups after radiotherapy, but the postradiotherapy DNA damage in the yoga group was slightly less when compared to the control group. An integrated approach of yoga intervention modulates the stress and DNA damage levels in breast cancer patients during radiotherapy.
Banerjee
Birendranath
B
Genome Stability Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Vadiraj
H S
HS
Ram
Amritanshu
A
Rao
Raghavendra
R
Jayapal
Manikandan
M
Gopinath
Kodaganur S
KS
Ramesh
B S
BS
Rao
Nalini
N
Kumar
Ajay
A
Raghuram
Nagarathna
N
Hegde
Sridevi
S
Nagendra
H R
HR
Prakash Hande
M
M
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D004249:DNA Damage / Q000528:radiation effects*; D005260:Female; D006801:Humans; D007194:India; D008875:Middle Aged; D011832:Radiation Injuries / Q000534:rehabilitation; D011878:Radiotherapy / Q000009:adverse effects; D013315:Stress, Psychological / Q000209:etiology / Q000628:therapy*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D015013:Yoga