Experimental validation of the new nanodosimetry-based cell survival model for mixed neutron and gamma-ray irradiation.
The new nanodosimetry-based linear-quadratic (LQ) formula has been reviewed for mixed-LET irradiation. V-79 Chinese hamster cells have been irradiated with a mixed-LET field of fission neutrons and gamma rays at the University of Maryland Training Reactor (MUTR). The results show that the experimental survival curve agrees well with that predicted by the new nanodosimetry-based LQ model. The experimental study described in this note, therefore, serves as a validation for the new model to be used for mixed-LET radiotherapies, e.g. 252Cf brachytherapy.
Wang
C-K Chris
CK
Nuclear/Radiological Engineering/Medical Physics Program Neely Research Center, Georgia Institute of Technology, 900 Atlantic Drive, Atlanta, GA 30332-0425, USA. chris.wang@nre.gatech.edu
Zhang
Xin
X
Gifford
Ian
I
Burgett
Eric
E
Adams
Vince
V
Al-Sheikhly
Mohamad
M
D000818:Animals; D001681:Biological Assay / Q000379:methods*; D002470:Cell Survival / Q000528:radiation effects*; D003198:Computer Simulation; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008954:Models, Biological; D036103:Nanotechnology / Q000379:methods*; D009502:Neutrons; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*