title: NPM1 mutations are more stable than FLT3 mutations during the course of disease in patients with acute myeloid leukemia.
abstract: NPM1 mutations have been reported to be the most frequent mutations in acute myeloid leukemia (AML). They are associated with a wide spectrum of morphologic subtypes of AML, normal karyotype and FLT3 mutations. The high frequency of NPM1 mutations might provide a suitable marker for monitoring residual disease of AML.
authors.forename: Michela
authors.initials: M
authors.lastname: Palmisano
authors.forename: Tiziana
authors.initials: T
authors.lastname: Grafone
authors.forename: Emanuela
authors.initials: E
authors.lastname: Ottaviani
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Testoni
authors.forename: Michele
authors.initials: M
authors.lastname: Baccarani
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
mesh_terms: D000208:Acute Disease; D004252:DNA Mutational Analysis; D018450:Disease Progression; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D018365:Neoplasm, Residual / Q000175:diagnosis / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D000090243:Nucleophosmin; D010750:Phosphoproteins / Q000235:genetics; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D010750:Phosphoproteins; D000090243:Nucleophosmin; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3