title: Stereochemical control of both C-C and C-N axial chirality in the synthesis of chiral N,O-biaryls.
abstract: A Rh(I)-catalyzed asymmetric [2 + 2 + 2] cycloaddition of achiral ynamides is described here. This work demonstrates a unique concept of stereochemical control of both the C-C and C-N axial chirality and provides an approach to the synthesis of chiral N,O-biaryls as well as chiral anilides.
authors.affiliation: Division of Pharmaceutical Sciences, Department of Chemistry, Rennebohm Hall, 777 Highland Avenue, University of Wisconsin, Madison, Wisconsin 53705, USA.
authors.forename: Jossian
authors.initials: J
authors.lastname: Oppenheimer
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
authors.forename: Ruth
authors.initials: R
authors.lastname: Figueroa
authors.forename: Whitney L
authors.initials: WL
authors.lastname: Johnson
mesh_terms: D002244:Carbon / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002244:Carbon; D009584:Nitrogen