Anti-dementia drugs and hippocampal-dependent memory in rodents.
Abnormalities in hippocampal structure and function are characteristics of early Alzheimer's disease (AD). Behavioral tests measuring hippocampal-dependent memory in rodents are often used to evaluate novel treatments for AD and other dementias. In this study, we review the effects of drugs marketed for the treatment of AD, such as the acetylcholinesterase inhibitors, donepezil, rivastigmine, galantamine and the N-methyl-D-aspartic acid antagonist, memantine, in rodent models of memory impairment. We also briefly describe the effects of novel treatments for cognitive impairment in rodent models of memory impairment, and discuss issues concerning the selection of the animal model and behavioral tests. Suggestions for future research are offered.
Yuede
Carla M
CM
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Dong
Hongxin
H
Csernansky
John G
JG
D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003704:Dementia / Q000188:drug therapy*; D004195:Disease Models, Animal; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008569:Memory Disorders / Q000188:drug therapy; D051379:Mice; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats
D002800:Cholinesterase Inhibitors; D018691:Excitatory Amino Acid Antagonists; D018697:Nootropic Agents