Room temperature ionic liquid as matrix medium for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography.
Using new solvent room temperature ionic liquid (IL) matrix media, testing of residual solvents in pharmaceutical preparations with static headspace gas chromatographic (SH-GC), is described. The purpose of this work was to demonstrate the feasibility of IL as diluent, six solvents utilized in synthesis of Adefovir Dipivoxil: acetonitrile, dichloromethane, N-methyl-2-pyrrolidone (NMP), toluene, dimethylformamide (DMF), n-butyl ether were dissolved in IL: 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF(4)). The method of external standard was used for quantitative analysis. Its performance was evaluated and validated: all the RSD were lower than 10%, the limits of detection were all of the ppm level and the method was both accurate and linear. And better sensitivities for the six solvents were gained with [bmim]BF(4) as diluent comparing with DMSO.
Liu
Feng-Hua
FH
Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang City, China.
Jiang
Ye
Y
D000225:Adenine / Q000031:analogs & derivatives / Q000032:analysis; D053000:Analytic Sample Preparation Methods; D001881:Borates / Q000737:chemistry; D002849:Chromatography, Gas / Q000379:methods*; D004340:Drug Contamination; D007093:Imidazoles / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D063065:Organophosphonates / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012997:Solvents / Q000032:analysis*; D013696:Temperature; D014465:Ultrasonics; D014835:Volatilization
C419324:1-butyl-3-methylimidazolium tetrafluoroborate; D001881:Borates; D007093:Imidazoles; D052578:Ionic Liquids; D063065:Organophosphonates; D004364:Pharmaceutical Preparations; D012997:Solvents; D000225:Adenine; C106812:adefovir dipivoxil