title: Statin therapy reduces serum levels of glycosylphosphatidylinositol-specific phospholipase D.
abstract: Statin therapy is associated with changes in low-density, very low-density, and high- density lipoprotein metabolism. The effect of statin therapy on a minor high-density lipoprotein particle containing glycosylphosphatidylinositol-specific phospholipase D has not been examined. Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) has been implicated in triglyceride metabolism. A double-blind, crossover design comparing the effect of simvastatin (80 mg) and atorvastatin (80 mg) on serum lipid and glycosylphosphatidylinositol-specific phospholipase D levels was conducted in 13 patients with low high-density lipoproteins. Both statins reduced cholesterol, triglycerides, and apolipoprotein B and significantly lowered serum glycosylphosphatidylinositol-specific phospholipase D levels (16%). This statin effect seems to occur in the plasma compartment as neither statin altered GPI-PLD mRNA levels in HepG2 cells. Serum glycosylphosphatidylinositol-specific phospholipase D levels are regulated by statins and may represent an additional biochemical mechanism for affecting serum triglyceride levels.
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. gpipld@hotmail.com
authors.forename: Mark A
authors.initials: MA
authors.lastname: Deeg
authors.forename: Nandita S
authors.initials: NS
authors.lastname: Raikwar
authors.forename: Cynthia
authors.initials: C
authors.lastname: Johnson
authors.forename: Craig D
authors.initials: CD
authors.lastname: Williams
mesh_terms: D000924:Anticholesteremic Agents / Q000494:pharmacology; D001055:Apolipoproteins B / Q000097:blood; D000069059:Atorvastatin; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006538:Heptanoic Acids / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010739:Phospholipase D / Q000097:blood* / Q000187:drug effects; D011758:Pyrroles / Q000494:pharmacology*; D019821:Simvastatin / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000924:Anticholesteremic Agents; D001055:Apolipoproteins B; D006538:Heptanoic Acids; D011758:Pyrroles; D014280:Triglycerides; D000069059:Atorvastatin; D019821:Simvastatin; D010739:Phospholipase D; C065017:glycoprotein phospholipase D