Oxidative stress is associated with greater mortality in older women living in the community.
OBJECTIVE
To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community.


METHODS
Longitudinal.


METHODS
Women's Health and Aging Study I, Baltimore, Maryland.


METHODS
Seven hundred forty-six moderately to severely disabled women, aged 65 and older, with baseline measures of serum protein carbonyls.


METHODS
Serum protein carbonyls, which consist of chemically stable aldehyde and ketone groups produced on protein side chains when they are oxidized, were measured using enzyme-linked immunosorbent assay. Multivariate logistic regression was used to adjust for potential confounders.


RESULTS
During 5 years of follow-up, 202 (27.1%) participants died. Geometric mean serum protein carbonyls were 0.091 nmol/mg in women who died and 0.083 nmol/mg in those who survived (P=.02). Log(e) protein carbonyls (nmol/mg) were associated with greater risk of mortality (hazards ratio=1.34, 95% confidence interval=1.01-1.79, P=.04) in a multivariate Cox proportional hazards model adjusting for age, current smoking, and body mass index.


CONCLUSIONS
Greater oxidative stress, as indicated by elevated serum protein carbonyl concentrations, was associated with greater risk of death in older women living in the community who were moderately to severely disabled. Prevention of oxidative stress may reduce the risk of mortality.
Semba
Richard D
RD
Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA. rdsemba@jhmi.edu
Ferrucci
Luigi
L
Sun
Kai
K
Walston
Jeremy
J
Varadhan
Ravi
R
Guralnik
Jack M
JM
Fried
Linda P
LP
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D002423:Cause of Death / Q000639:trends*; D005260:Female; D005500:Follow-Up Studies; D016330:Frail Elderly; D006305:Health Status Indicators; D006801:Humans; D008396:Maryland / Q000453:epidemiology; D018384:Oxidative Stress; D050050:Protein Carbonylation; D011506:Proteins / Q000378:metabolism*; D018570:Risk Assessment; D015996:Survival Rate / Q000639:trends; D016387:Women's Health
D011506:Proteins