Dominantly-inherited lop ears.
We describe a four-generation Chinese family that included five members who had an isolated bilateral lop ear anomaly. The presentation suggested a dominant mode of inheritance. The absence of male-to-male transmission does not exclude an X-linked dominant mode of inheritance. Since the phenotypic anomaly of the male proband was no more severe than the affected female members, an autosomal dominant mode of inheritance is most likely.
Leung
Alexander K C
AK
Department of Pediatrics, the University of Calgary, and the Alberta Children's Hospital, Calgary, Alberta, Canada. aleung@ucalgary.ca
Kong
Albert Y F
AY
Robson
W Lane M
WL
McLeod
D Ross
DR
D000013:Congenital Abnormalities / Q000235:genetics*; D004423:Ear / Q000002:abnormalities*; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008297:Male