title: Blood pressure changes of elderly hypertensive patients during dental extraction under sedation with continuous intravenous infusion of midazolam.
abstract: OBJECTIVE
  To evaluate the changes in blood pressure (BP) of elderly hypertensive patients having dental extraction under sedation with continuous intravenous infusion of midazolam.
  
  
  METHODS
  One hundred elderly hypertensive patients undergoing dental extraction were recruited for this single-blind, randomized, controlled study. Patients in intervention group (n = 50) were given midazolam dissolved in glucose solution and patients in control group (n = 50) were given glucose solution only with communication technique. Systolic BP (SBP) and diastolic BP (DBP) were recorded in five time points.
  
  
  RESULTS
  Under basal conditions, intervention group did not show significant difference in BP compared with control group. Before sedation, mean values of SBP and DBP (especially SBP) significantly increased compared with basal conditions in both groups (P < 0.05). During dental extraction sessions, mean values of BP in intervention group significantly decreased than control group (P < 0.05), but coefficient of variation did show significant difference in both groups.
  
  
  CONCLUSIONS
  Continuous intravenous infusion of midazolam has been proved to be very successful in controlling BP of elderly patients having dental extraction.
authors.affiliation: Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730.
authors.forename: Ji-Zhi
authors.initials: JZ
authors.lastname: Zhao
authors.forename: Kuo
authors.initials: K
authors.lastname: Wan
authors.forename: Quan
authors.initials: Q
authors.lastname: Jing
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D003971:Diastole / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D006993:Hypnotics and Sedatives / Q000494:pharmacology / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008874:Midazolam / Q000494:pharmacology / Q000627:therapeutic use*; D013599:Systole / Q000187:drug effects; D014081:Tooth Extraction / Q000379:methods*
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam