title: Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes.
abstract: BACKGROUND
  The effects of different dietary fatty acids on postprandial lipid metabolism in type 2 diabetic patients are still debated.
  
  
  OBJECTIVE
  To evaluate the effects of monounsaturated (MUFA) vs. saturated fat (SAFA)-rich diets on postprandial lipemia and adipose tissue lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL) in type 2 diabetes.
  
  
  METHODS
  Eleven type 2 diabetic patients followed, in random order, a diet rich in MUFA (SAFA 8%, MUFA 23%) and another rich in SAFA (SAFA 17%, MUFA 15%) for a period of 3 weeks each. At the end of the two diets, a standard fat-rich meal was administered and subcutaneous fat biopsies were performed at fasting and 6h after the test meal.
  
  
  RESULTS
  Neither diet induced significant changes in meal lipid tolerance, except for a faster (at 2h) increase in chylomicron triglycerides and a significant decrease in small VLDL triglyceride incremental area after the MUFA diet (-13.6+/-4.7 mg/dl*6h vs. -2.2+/-3.7 mg/dl*6h, p<0.005) (M+/-SEM). LPL and HSL activities were significantly increased after the MUFA diet.
  
  
  CONCLUSIONS
  A MUFA-rich diet reduces postprandial small VLDL triglycerides in type 2 diabetic patients compared to a SAFA-rich diet, and modifies lipolytic enzymes in adipose tissue.
authors.affiliation: Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. rivelles@unina.it
authors.forename: Angela A
authors.initials: AA
authors.lastname: Rivellese
authors.forename: Rosalba
authors.initials: R
authors.lastname: Giacco
authors.forename: Giovanni
authors.initials: G
authors.lastname: Annuzzi
authors.forename: Claudia
authors.initials: C
authors.lastname: De Natale
authors.forename: Lidia
authors.initials: L
authors.lastname: Patti
authors.forename: Lucrezia
authors.initials: L
authors.lastname: Di Marino
authors.forename: Valentina
authors.initials: V
authors.lastname: Minerva
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Costabile
authors.forename: Carmela
authors.initials: C
authors.lastname: Santangelo
authors.forename: Roberta
authors.initials: R
authors.lastname: Masella
authors.forename: Gabriele
authors.initials: G
authors.lastname: Riccardi
mesh_terms: D000273:Adipose Tissue / Q000201:enzymology; D019540:Area Under Curve; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008049:Lipase / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D019518:Postprandial Period; D002787:Sterol Esterase / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D014280:Triglycerides; D002787:Sterol Esterase; D008049:Lipase; D008071:Lipoprotein Lipase