title: Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives.
abstract: A new series of diarylmethylnapthyloxy ethylamines were synthesized by aminoalkylation of diarylmethylnaphthols which were obtained by Friedel-Crafts alkylation on 1- and 2-naphthols using diarylcarbinols as the alkylating agents. The title compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H(37)R(v) in vitro and showed MIC in the range of 3.12-25 microg/ml.
authors.affiliation: Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India.
authors.forename: Sajal Kumar
authors.initials: SK
authors.lastname: Das
authors.forename: Gautam
authors.initials: G
authors.lastname: Panda
authors.forename: Vinita
authors.initials: V
authors.lastname: Chaturvedi
authors.forename: Y S
authors.initials: YS
authors.lastname: Manju
authors.forename: Anil K
authors.initials: AK
authors.lastname: Gaikwad
authors.forename: Sudhir
authors.initials: S
authors.lastname: Sinha
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D008745:Methylation; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009284:Naphthols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D009284:Naphthols