In vitro angiotensin converting enzyme inhibiting activity of Salsola oppositifolia Desf., Salsola soda L. and Salsola tragus L.
In order to support scientifically the traditional use of Salsola species in the treatment of hypertension, this study was designed to evaluate the hypotensive properties of Salsola oppositifolia, S. soda and S. tragus. In vitro bio-assay based on the measured enzymatic cleavage of the chromophore-fluorophore-labelled substrate dansyltriglycine into dansylglycine and diglycine by angiotensin converting enzyme (ACE) was performed. EtOAc extracts of S. oppositifolia and S. soda exhibited an interesting activity with an IC(50) of 181.04 and 284.27 microg mL(-1), respectively.
Loizzo
Monica Rosa
MR
Department of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende, CS, Italy. mr.loizzo@unical.it
Tundis
Rosa
R
Statti
Giancarlo Antonio
GA
Passalacqua
Nicodemo Giuseppe
NG
Peruzzi
Lorenzo
L
Menichini
Francesco
F
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis*; D010936:Plant Extracts / Q000494:pharmacology; D031248:Salsola / Q000737:chemistry*; D013045:Species Specificity; D013634:Tannins / Q000032:analysis
D000806:Angiotensin-Converting Enzyme Inhibitors; D010936:Plant Extracts; D013634:Tannins