Caudate volume in offspring of patients with schizophrenia.
Caudate nuclei are smaller in drug-naive people with schizophrenia but larger in antipsychotic-treated patients. In this magnetic resonance imaging study we found volume reduction of right and left caudate by 8.9 and 8.1% respectively in 50 offspring without psychosis of patients with schizophrenia compared with 53 age- and gender-matched controls, providing new evidence that caudate volume reduction may be a trait-related abnormality in schizophrenia.
Rajarethinam
Rajaprabhakaran
R
Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Street UHC-9B, Detroit, Michigan 48201, USA.
Upadhyaya
Ameet
A
Tsou
Pon
P
Upadhyaya
Margie
M
Keshavan
Matcheri S
MS
D000293:Adolescent; D002421:Caudate Nucleus / Q000473:pathology*; D002648:Child; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D016571:Neural Networks, Computer; D012016:Reference Values; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000235:genetics*