title: [Hormone replacement Up-to-date. Adrenopause and DHEA replacement therapy].
abstract: It is well known that serum levels of DHEA and its sulfate form DHEA-S decline along with aging. This phenomenon is called adrenopause in contrast to menopause. Experimental studies show that DHEA has many beneficial effects such as anti-diabetic, anti-atherosclerosis, and anti-osteoporosis effects. Therefore, DHEA replacement has been performed as anti-aging therapy. Several clinical trials of DHEA replacement demonstrated the improvement of sense of well-being, lipid metabolism, and bone metabolism. We recently reported on the result of short-term administration of DHEA in healthy Japanese volunteer men. It is thought that further accumulation of original data is necessary to promote DHEA replacement therapy in Japan.
authors.affiliation: Kyushu University, Graduate School of Medical Sciences, Department of Geriatric Medicine, Japan.
authors.forename: Keizo
authors.initials: K
authors.lastname: Ohnaka
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D003687:Dehydroepiandrosterone / Q000172:deficiency* / Q000627:therapeutic use*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008297:Male
chemical_list: D003687:Dehydroepiandrosterone