title: Conventional versus invaginated stripping of the great saphenous vein: a randomized, double-blind, controlled clinical trial.
abstract: BACKGROUND
  An invaginated strip of the great saphenous vein (GSV) may be associated with diminished blood loss and less discomfort compared to conventional stripping in patients with unilateral primary GSV varicosis.
  
  
  METHODS
  Ninety-two patients were randomized for conventional (CON) or invaginated (INVAG) stripping and were followed for 26 weeks postoperatively.
  
  
  RESULTS
  Both groups (n = 46) were well balanced for age, gender distribution, and body mass index. The CON group lost twice as much blood compared to the INVAG group (CON: 28 +/- 4 g, INVAG: 15 +/- 2 g, p < 0.001). Infragenual incision length following a conventional strip was twice as long (CON: 16 +/- 1 mm, INVAG: 8 +/- 1 mm, p < 0.001). Pain as measured with a visual analog scale (minimal 0, max 10) decreased in both groups in a similar fashion from 3.2 +/- 0.3 preoperatively to 0.6 +/- 0.2 after 26 weeks (p < 0.001). Saphenous nerve damage after one month was observed in four CON patients compared to no patients following invagination. Return to work was not different (CON: 13 +/- 2 days, INVAG: 11 +/- 2 days).
  
  
  CONCLUSIONS
  Invagination of the GSV in uncomplicated primary varicosis may be associated with less surgical trauma compared to a conventional stripping technique.
authors.affiliation: Department of Surgery, Máxima Medisch Centrum, Veldhoven, The Netherlands. m.scheltinga@mmc.nl
authors.forename: Marc R
authors.initials: MR
authors.lastname: Scheltinga
authors.forename: Edwin R
authors.initials: ER
authors.lastname: Wijburg
authors.forename: Bram J
authors.initials: BJ
authors.lastname: Keulers
authors.forename: Karin E
authors.initials: KE
authors.lastname: de Kroon
mesh_terms: D016063:Blood Loss, Surgical / Q000706:statistics & numerical data; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D012501:Saphenous Vein / Q000601:surgery*; D014648:Varicose Veins / Q000601:surgery*; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000379:methods*