Synthesis and evaluation of antifungal properties of a series of the novel 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and its analogues.
A series of 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and various analogues have been synthesized in excellent isolated yields starting from various arylidenemalononitrile and 3-amino-2-cyclohexen-1-one in 1-propanol as solvent at reflux temperature in the absence of any added catalyst. All the synthesized compounds were evaluated for their antifungal activity. The relationship between functional group variation and biological activity of the evaluated compounds is discussed in the article.
Gholap
Atul R
AR
Division of Organic Chemistry; Technology, National Chemical Laboratory, Pune, India.
Toti
Kiran S
KS
Shirazi
Fazal
F
Kumari
Ratna
R
Bhat
Manoj Kumar
MK
Deshpande
Mukund V
MV
Srinivasan
Kumar V
KV
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D025301:Hyphae / Q000187:drug effects; D009570:Nitriles / Q000138:chemical synthesis / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology*
C525228:2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile; D000935:Antifungal Agents; D009570:Nitriles; D011804:Quinolines