Synthesis of chlorogenic acid derivatives with promising antifungal activity.
Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids. Most of the compounds exhibited significant potency against Cryptococcus neoformans and Candida species with low toxicity to brine shrimps. The 4,5-dihydroxyl groups in the quinic acid moiety were necessary for the activity and introduction of a free amino group increased the inhibitory activity against Aspergillus fumigatus.
Ma
Chao-Mei
CM
School of Pharmacy, Memorial University of Newfoundland, St John's, NL, Canada.
Kully
Maureen
M
Khan
Jehangir K
JK
Hattori
Masao
M
Daneshtalab
Mohsen
M
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D002726:Chlorogenic Acid / Q000031:analogs & derivatives*; D003455:Cryptococcus neoformans / Q000187:drug effects*
D000935:Antifungal Agents; D002726:Chlorogenic Acid