title: For IRES trans-acting factors, it is all about location.
abstract: The translation of many proteins involved in transcription, cell cycle progression, apoptosis and cell survival is mediated by internal ribosome entry sites (IRESs) present within the 5'-untranslated regions (5'-UTRs) of their messenger RNA molecules (mRNAs). Several recent reports now demonstrate that the proteins controlling IRES-dependent translation initiation are regulated by their subcellular localization.
authors.affiliation: Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
authors.forename: S M
authors.initials: SM
authors.lastname: Lewis
authors.forename: M
authors.initials: M
authors.lastname: Holcik
mesh_terms: D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D014176:Protein Biosynthesis / Q000187:drug effects / Q000502:physiology; D012333:RNA, Messenger / Q000502:physiology*; D012270:Ribosomes / Q000378:metabolism*; D015534:Trans-Activators / Q000502:physiology*; D014750:Vincristine / Q000494:pharmacology
chemical_list: D012333:RNA, Messenger; D015534:Trans-Activators; D014750:Vincristine