Self-renewal in the fly kidney.
Tissue stem cells are typically rare and located in niches that prescribe low rates of cell division and survival. In the latest issue of Cell Stem Cell, Singh et al. (2007) demonstrate that, in the adult fly, epithelial cells exist that are neither in niches nor in small numbers, divide at high rates, and are multipotent.
Affolter
Markus
M
Biozentrum der Universität Basel, Kingelbergstrasse 70, CH-4056 Basel, Switzerland. markus.affolter@unibas.ch
Barde
Yves
Y
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000502:physiology*; D053612:Janus Kinases / Q000378:metabolism; D007668:Kidney / Q000166:cytology / Q000502:physiology*; D008317:Malpighian Tubules / Q000166:cytology / Q000502:physiology*; D039902:Multipotent Stem Cells / Q000166:cytology / Q000502:physiology*; D050791:STAT Transcription Factors / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
D029721:Drosophila Proteins; D050791:STAT Transcription Factors; D014157:Transcription Factors; D053612:Janus Kinases; C085845:hop protein, Drosophila