Three-, 6-, and 12-month results of autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction.
BACKGROUND
There are only few data on long-term effectiveness of the stem cell therapy.


OBJECTIVE
We studied the time course of global and regional left ventricular function in patients with acute myocardial infarction within 1 year after the autologous mononuclear bone marrow cell transplantation.


METHODS
Sixty patients with a first acute myocardial infarction, who had been randomized into 3 groups, completed a 12-month protocol. Two groups were intracoronarily given bone marrow cells in either higher (10(8) cells, HD group, n=20) or lower (10(7) cells, LD group, n=20) doses. Twenty patients without cell transplantation served as a control (C) group. Doppler tissue imaging and the gated technetium-99m sestamibi single photon emission computed tomography were performed before cell transplantation and at 3, 6, and 12 months later.


RESULTS
The baseline peak systolic velocities of longitudinal contraction of the infarcted wall (S(infarct)) of 5.2 cm/s, 4.6 cm/s, and 4.4 cm/s in C, LD, and HD groups increased by 0.0 cm/s, 0.3 cm/s (p=NS vs. C group), and by 0.7 cm/s (p<0.05 vs. C group), respectively, at 3 months. At 12 months, however, the corresponding changes from baseline values of 0.1 cm/s, 0.2 cm/s, and 0.6 cm/s did not differ significantly (all p=NS). In contrast, the post-transplant improvements in the left ventricular ejection fraction by 6%, 7%, and 7% at months 3, 6, and 12, respectively, were preserved in HD group patients during the whole 12-month follow-up and remained significantly better as compared to controls.


CONCLUSIONS
In our study, the autologous mononuclear bone marrow cell transplantation provided sustained improvement in global left ventricular systolic function in patients with acute myocardial infarction. However, when evaluating regional systolic function of the infarcted wall, the short-term benefit was partially lost during the 12-month follow-up.
Meluzín
Jaroslav
J
1st Department of Internal Medicine/Cardioangiology, St Anna Hosp, MU Czech Republic. jaroslav.meluzin@fnusa.cz
Janousek
Stanislav
S
Mayer
Jirí
J
Groch
Ladislav
L
Hornácek
Ivan
I
Hlinomaz
Ota
O
Kala
Petr
P
Panovský
Roman
R
Prásek
Jirí
J
Kamínek
Milan
M
Stanícek
Jaroslav
J
Klabusay
Martin
M
Korístek
Zdenek
Z
Navrátil
Milan
M
Dusek
Ladislav
L
Vinklárková
Jaroslava
J
D000704:Analysis of Variance; D016026:Bone Marrow Transplantation / Q000379:methods; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology / Q000601:surgery*; D049268:Positron-Emission Tomography; D020127:Recovery of Function; D033581:Stem Cell Transplantation / Q000379:methods; D015899:Tomography, Emission-Computed, Single-Photon; D014182:Transplantation, Autologous; D016277:Ventricular Function, Left