Outcomes of dosage adjustments used to manage antiretroviral drug interactions.
Dosage adjustments are often used to manage HIV drug interactions, but little is known about their clinical significance. We examined patients from the Ontario HIV Cohort Study to assess the effects of dosage adjustments on plasma viral load. A significant reduction (0.67 log10 copies/mL) in viral load was associated with adjustments to manage efavirenz-based interactions (95% confidence interval, -1.33 to -0.01) but was not observed after adjustments to manage rifabutin-based (difference in viral load, 0.03 log10 copies/mL; 95% confidence interval, -0.71 to 0.77) or nevirapine-based interactions (difference in viral load, 0.09 log10 copies/mL; 95% confidence interval, -0.83 to 1.01).
Park-Wyllie
Laura Y
LY
Centre for Research on Inner City Health, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, Canada. parkwylliel@smh.toronto.on.ca
Levine
Mitchell A
MA
Holbrook
Anne
A
Thabane
Lehana
L
Antoniou
Tony
T
Yoong
Deborah
D
Kam
Derek
D
Bayoumi
Ahmed M
AM
D044966:Anti-Retroviral Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D009864:Ontario; D016896:Treatment Outcome; D019562:Viral Load