Rare HVR1-HCV genotype 1b variants in patients with B non Hodgkin's lymphoma. Comparison with viral sequences detected in cases of lymphoproliferative disorders and B cell compartmentalisation.
We compared the E2-HVR1 region in HCV-1b positive B-NHL cases from a multicenter study with sequences from studies related to lymphoproliferative disorders and B cell compartmentalisation. We found rare and unique mutations both in B-NHL isolates and in cases with lymphoproliferative disorders and lymphocyte infection. These rare mutations could have an important effect on HVR1 region and, as a consequence, on the binding of E2 on CD81, with a possible implication for both antigenic stimulation and HCV entry. In conclusion, the HCV predominants circulating in B-NHL cases seem to be associated with clonal selection of rare variants.
Dettori
Stefano
S
Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune-Mediated Disease, Istituto Superiore di Sanita, Rome.
Argentini
Claudio
C
Marcucci
Fabrizio
F
Spada
Enea
E
Chionne
Paola
P
Candido
Angela
A
Madonna
Elisabetta
E
Ciccaglione
Anna Rita
AR
Bianco
Elvira
E
Iannitto
Emilio
E
Musto
Pellegrino
P
Liso
Vincenzo
V
De Renzo
Amalia
A
Pagano
Livio
L
Nieddu
Grazia
G
Pulsoni
Alessandro
A
Mele
Alfonso
A
Rapicetta
Maria
M
D015703:Antigens, CD / Q000378:metabolism; D014644:Genetic Variation; D016174:Hepacivirus / Q000145:classification / Q000235:genetics*; D006526:Hepatitis C / Q000150:complications / Q000821:virology*; D018936:Hepatitis C Antigens / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007558:Italy; D016393:Lymphoma, B-Cell / Q000150:complications / Q000821:virology*; D008969:Molecular Sequence Data; D012641:Selection, Genetic; D013045:Species Specificity; D060225:Tetraspanin 28; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism