title: Effects of serum on in vitro susceptibility testing of echinocandins.
abstract: The effects of protein binding on the activities of caspofungin, anidulafungin, and micafungin were evaluated against Candida and Aspergillus species. Adding human serum sharply increased the MICs of micafungin and anidulafungin and modestly affected the MIC of caspofungin. The increase in MICs does not appear consistent with the rate of protein binding for the three compounds.
authors.affiliation: Marmara University, Tophanelioglu caddesi, No:13, 34662 Altunizade, Istanbul, Turkey. zekaver@marmara.edu.tr
authors.forename: Zekaver
authors.initials: Z
authors.lastname: Odabasi
authors.forename: Victor
authors.initials: V
authors.lastname: Paetznick
authors.forename: John H
authors.initials: JH
authors.lastname: Rex
authors.forename: Luis
authors.initials: L
authors.lastname: Ostrosky-Zeichner
mesh_terms: D000077612:Anidulafungin; D001230:Aspergillus / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D000077336:Caspofungin; D054714:Echinocandins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D055666:Lipopeptides; D008074:Lipoproteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000077551:Micafungin; D008826:Microbial Sensitivity Tests; D011485:Protein Binding; D044967:Serum / Q000737:chemistry / Q000378:metabolism*