The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists.
The DAVID Gene Functional Classification Tool http://david.abcc.ncifcrf.gov uses a novel agglomeration algorithm to condense a list of genes or associated biological terms into organized classes of related genes or biology, called biological modules. This organization is accomplished by mining the complex biological co-occurrences found in multiple sources of functional annotation. It is a powerful method to group functionally related genes and terms into a manageable number of biological modules for efficient interpretation of gene lists in a network context.
Huang
Da Wei
DW
Laboratory of Immunopathogenesis and Bioinformatics, Clinical Services Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Sherman
Brad T
BT
Tan
Qina
Q
Collins
Jack R
JR
Alvord
W Gregory
WG
Roayaei
Jean
J
Stephens
Robert
R
Baseler
Michael W
MW
Lane
H Clifford
HC
Lempicki
Richard A
RA
D000465:Algorithms; D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods; D003627:Data Interpretation, Statistical; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D005821:Genetic Techniques; D023281:Genomics; D006801:Humans; D008962:Models, Theoretical; D020411:Oligonucleotide Array Sequence Analysis; D010363:Pattern Recognition, Automated; D012984:Software