title: Epidermolysis bullosa acquisita in a Great Dane.
abstract: Autoimmune subepidermal blistering diseases in dogs were all classified as bullous pemphigoid until 1998. Since then, refinements in reagents and immunological techniques have allowed diseases which are histologically similar but which have a different molecular pathogenesis to be described. This report describes the first case of one such disease, epidermolysis bullosa acquisita, to be documented in the UK. The dog presented with a severe blistering and ulcerative disease affecting the oral cavity, pinnae and distal limbs. The diagnosis was confirmed by histopathology and direct and indirect immunofluorescent demonstration of immunoglobulin G reactivity to basement membrane antigens. Treatment with glucocorticoids, azathioprine, colchicine and an intravenous infusion of immunoglobulins resulted in complete resolution. The drugs were discontinued 12 months after the start of treatment and the dog remained in remission.
authors.affiliation: Division of Companion Animal Studies, Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 5DU, UK.
authors.forename: P B
authors.initials: PB
authors.lastname: Hill
authors.forename: P
authors.initials: P
authors.lastname: Boyer
authors.forename: P
authors.initials: P
authors.lastname: Lau
authors.forename: J
authors.initials: J
authors.lastname: Rybnicek
authors.forename: J
authors.initials: J
authors.lastname: Hargreaves
authors.forename: T
authors.initials: T
authors.lastname: Olivry
mesh_terms: D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use; D003078:Colchicine / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D004817:Epidermis / Q000473:pathology*; D016107:Epidermolysis Bullosa Acquisita / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D005455:Fluorescent Antibody Technique; D005938:Glucocorticoids / Q000627:therapeutic use; D007074:Immunoglobulin G / Q000032:analysis; D007136:Immunoglobulins / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D012074:Remission Induction