title: Possible association between the -2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain.
abstract: Antipsychotic-induced weight gain has important effects on treatment compliance and long-term health. Several reports have indicated that a -2548A/G single-nucleotide polymorphism (SNP) of the leptin gene is associated with antipsychotic-induced weight gain. We hypothesized that there is a similar relationship between the -2548A/G SNP and olanzapine-induced weight gain. A total of 74 Korean schizophrenic patients were examined. Their weight was measured before starting olanzapine and after long-term treatment lasting for at least 3 months. The weight gain was significantly higher for patients with the AG genotype than for those with the AA genotype (p=0.029). Analysis of covariance also showed the difference of weight gain was still significant when adjusted for sex and treatment duration (p=0.046). This finding supports the presence of a relationship between the -2548A/G SNP of the leptin gene and weight gain in Korean schizophrenic patients receiving olanzapine treatment.
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Seung-Gul
authors.initials: SG
authors.lastname: Kang
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Park
authors.forename: Jung-Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Changsu
authors.initials: C
authors.lastname: Han
authors.forename: Yong-Ku
authors.initials: YK
authors.lastname: Kim
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Sook-Haeng
authors.initials: SH
authors.lastname: Joe
authors.forename: In-Kwa
authors.initials: IK
authors.lastname: Jung
authors.forename: Leen
authors.initials: L
authors.lastname: Kim
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D015992:Body Mass Index; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D020738:Leptin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics