title: Fast Fourier transform-based support vector machine for subcellular localization prediction using different substitution models.
abstract: There are approximately 10(9) proteins in a cell. A hotspot in bioinformatics is how to identify a protein subcellular localization, if its sequence is known. In this paper, a method using fast Fourier transform-based support vector machine is developed to predict the subcellular localization of proteins from their physicochemical properties and structural parameters. The prediction accuracies reached 83% in prokaryotic organisms and 84% in eukaryotic organisms with the substitution model of the c-p-v matrix (c, composition; p, polarity; and v, molecular volume). The overall prediction accuracy was also evaluated using the "leave-one-out" jackknife procedure. The influence of the substitution model on prediction accuracy has also been discussed in the work. The source code of the new program is available on request from the authors.
authors.affiliation: College of Chemistry, Sichuan University, Chengdu 610064, China.
authors.forename: Zhimeng
authors.initials: Z
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Jiang
authors.forename: Menglong
authors.initials: M
authors.lastname: Li
authors.forename: Lina
authors.initials: L
authors.lastname: Sun
authors.forename: Rongying
authors.initials: R
authors.lastname: Lin
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D005583:Fourier Analysis; D008954:Models, Biological; D011237:Predictive Value of Tests; D011506:Proteins / Q000032:analysis / Q000235:genetics* / Q000378:metabolism*; D012984:Software; D013347:Subcellular Fractions / Q000378:metabolism