title: PMMA bone cement containing a quaternary amine comonomer with potential antibacterial properties.
abstract: An iodinated quaternary amine dimethacrylate monomer was synthesized and incorporated as a comonomer in acrylic bone cements. Bone cement is used in orthopaedic surgery and imparting antibacterial properties to the cement can be beneficial in the lowering of bacterial infection post surgery. PMMA based bone cements were modified by copolymerising the monomer methylmethacrylate (MMA) with a quaternary amine dimethacrylate by using the redox initiator activator system as used for curing commercial bone cements. The cements were prepared using the commercial PMMA bone cement CMW and the liquid component was modified with the amine to render antimicrobial properties to the cement. The physical, mechanical, and antimicrobial properties of the modified cements were evaluated; in addition, the viability of the cement to function as a orthopaedic cement was also established, especially with an advantage of it being radiopaque, due to the inclusion of the iodine containing quaternary amine. The cytotoxicity of the modified cements were tested using a human cell model and the results indicated that the cells remained metabolically active and proliferated when placed in direct contact with the experimental cement specimens. The cements and their eluants did not evoke any cytotoxic response.
authors.affiliation: Department of Biomaterials, King's College London Dental Institute at Guy's, King's, and St. Thomas' Hospitals, Floor 17, Guy's Tower, London Bridge, London SE1 9RT, United Kingdom. sanjukta.deb@kcl.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Deb
authors.forename: R
authors.initials: R
authors.lastname: Doiron
authors.forename: L
authors.initials: L
authors.lastname: Disilvio
authors.forename: S
authors.initials: S
authors.lastname: Punyani
authors.forename: H
authors.initials: H
authors.lastname: Singh
mesh_terms: D000588:Amines / Q000737:chemistry / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D001826:Body Fluids / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry / Q000378:metabolism; D045744:Cell Line, Tumor; D019245:Compressive Strength; D004926:Escherichia coli / Q000378:metabolism; D006801:Humans; D008422:Materials Testing; D015394:Molecular Structure; D019904:Polymethyl Methacrylate / Q000737:chemistry / Q000378:metabolism; D013314:Stress, Mechanical; D013499:Surface Properties