The value of computed tomography-guided percutaneous lung biopsy for diagnosis of invasive fungal infection in immunocompromised patients.
We assessed Calcofluor white staining, Aspergillus polymerase chain reaction, and a galactomannan enzyme immunoassay for diagnosis of fungal infection with use of computed tomography-guided percutaneous lung biopsy specimens obtained from 61 patients. The sensitivity and specificity of computerized tomography, Aspergillus polymerase chain reaction, and galactomannan enzyme immunoassay were 100% and 50%, 100% and 86%, and 88% and 94%, respectively.
Lass-Flörl
Cornelia
C
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, University Hospital Innsbruck, Innsbruck, Tirol, Austria. cornelia.lass-floerl@i-med.ac.at
Resch
Gudrun
G
Nachbaur
David
D
Mayr
Astrid
A
Gastl
Günther
G
Auberger
Jutta
J
Bialek
Ralf
R
Freund
Martin C
MC
D000328:Adult; D001228:Aspergillosis / Q000175:diagnosis*; D001230:Aspergillus / Q000235:genetics*; D001557:Benzenesulfonates; D001706:Biopsy / Q000379:methods*; D003287:Contrast Media; D005189:False Positive Reactions; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D016867:Immunocompromised Host; D007124:Immunoenzyme Techniques / Q000379:methods; D008172:Lung Diseases, Fungal / Q000175:diagnosis*; D008297:Male; D008351:Mannans / Q000032:analysis*; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods