TGF-beta1 suppresses T cell infiltration and VP2 puff B mutation enhances apoptosis in acute polioencephalitis induced by Theiler's virus.
GDVII and DA strains of Theiler's murine encephalomyelitis virus (TMEV) differ in VP2 puff B. One week after GDVII virus infection, SJL/J mice had large numbers of TUNEL+ apoptotic cells with a relative lack of T cell infiltration in the brain. DA viruses with mutation in puff B induced higher levels of apoptosis than wild-type DA virus, but levels of inflammation in brains were similar between DA and DA virus mutants. The difference in inflammation among TMEVs could be due to TGF-beta1 expression that was seen only in GDVII virus infection and negatively correlated with CD3+ T cell infiltration.
Tsunoda
Ikuo
I
Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA.
Libbey
Jane E
JE
Fujinami
Robert S
RS
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000276:immunology; D017252:CD3 Complex / Q000276:immunology; D036022:Capsid Proteins / Q000235:genetics*; D002634:Chemotaxis, Leukocyte / Q000235:genetics / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D020287:In Situ Nick-End Labeling; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D009154:Mutation / Q000235:genetics; D011051:Poliomyelitis / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D013601:T-Lymphocytes / Q000276:immunology*; D017945:Theilovirus / Q000276:immunology*; D053773:Transforming Growth Factor beta1 / Q000276:immunology*