Specialized circuits from primary visual cortex to V2 and area MT.
Primary visual cortex recombines inputs from magnocellular (M) and parvocellular (P) streams to create functionally specialized outputs. Understanding these input-output relationships is complicated by the fact that layer 4B, which provides outputs to dorsal visual areas, contains multiple cell types. Using a modified rabies virus that expresses green fluorescent protein, we show that layer 4B neurons projecting to MT are a majority spiny stellate, whereas those projecting to V2 are overwhelmingly pyramidal. Regardless of cell type, MT-projecting neurons have larger cell bodies, more dendritic length, and are deeper within layer 4B. Furthermore, MT-projecting pyramidal neurons are located preferentially underneath cytochrome oxidase blobs, indicating that MT-projecting neurons of both types restrict their dendrites to M-recipient zones. We conclude that MT-projecting layer 4B neurons are specialized for the fast transmission of information from the M pathway, while V2-projecting neurons are likely to mediate slower computations involving mixed M and P signals.
Nassi
Jonathan J
JJ
Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Callaway
Edward M
EM
D000818:Animals; D001370:Axonal Transport / Q000502:physiology; D001931:Brain Mapping / Q000379:methods; D048430:Cell Shape / Q000502:physiology; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure; D003576:Electron Transport Complex IV / Q000378:metabolism; D005822:Genetic Vectors / Q000235:genetics; D049452:Green Fluorescent Proteins / Q000235:genetics; D007395:Interneurons / Q000166:cytology / Q000502:physiology; D008251:Macaca; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D017966:Pyramidal Cells / Q000166:cytology / Q000502:physiology; D011820:Rabies virus / Q000235:genetics; D013194:Staining and Labeling / Q000379:methods; D013702:Temporal Lobe / Q000166:cytology* / Q000502:physiology; D014793:Visual Cortex / Q000166:cytology* / Q000502:physiology; D014795:Visual Pathways / Q000166:cytology* / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*