Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries.
The purpose of the present study was to identify gene polymorphisms that confer susceptibility to recurrent restenosis after bare-metal stenting of coronary arteries, and thereby to assess the genetic risk for this condition. The study population comprised 527 unrelated Japanese individuals, including 28 subjects who developed in-stent restenosis two or more times and 499 subjects without restenosis. The genotypes for 142 polymorphisms of 121 candidate genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Eleven polymorphisms were related (P<0.05) to the prevalence of recurrent in-stent restenosis as determined by the Chi-square test. Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and hypercholesterolemia revealed that the -55Cright curved arrow T polymorphism of the uncoupling protein 3 gene (UCP3) was significantly (P=0.0006 in a recessive model) associated with the prevalence of recurrent in-stent restenosis, with the T allele representing a risk factor for this condition. A stepwise forward selection procedure showed that the UCP3 genotype significantly (P=0.0014, recessive model) affected the prevalence of recurrent in-stent restenosis. Determination of the genotype for UCP3 may thus contribute to assessment of the genetic risk for recurrent in-stent restenosis.
Oguri
Mitsutoshi
M
Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.
Kato
Kimihiko
K
Hibino
Takeshi
T
Yokoi
Kiyoshi
K
Segawa
Tomonori
T
Matsuo
Hitoshi
H
Watanabe
Sachiro
S
Nozawa
Yoshinori
Y
Murohara
Toyoaki
T
Yamada
Yoshiji
Y
D000368:Aged; D016009:Chi-Square Distribution; D023903:Coronary Restenosis / Q000209:etiology* / Q000235:genetics*; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008055:Lipids / Q000032:analysis; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012008:Recurrence; D012044:Regression Analysis; D015607:Stents / Q000009:adverse effects*; D000071247:Uncoupling Protein 3