The effect of mineral trioxide aggregate on the contractility of the rat thoracic aorta.
Mineral trioxide aggregate (MTA) is being advocated for vital pulp therapy. In the case of direct pulp capping, hemorrhage control is an important step on success, but little is known about the effect of MTA on pulpal bleeding. In addition, there has been a lack of information on the effect of MTA on smooth muscle contraction, such as can occur in the blood vessels of dental pulp. The present study assessed the vascular effects of MTA, using the rat aortic ring preparations as a tissue model. MTA (100-500 mg) induced dose-dependent contraction in rat thoracic aorta. The contractile effect of MTA was blocked by calcium channel blocker nifedipine (1 muM). These data suggest that the vasoconstrictor property of MTA is related to calcium influx and it may allow proper control of hemorrhage which is critical for the success of any pulp-capping treatment.
Tunca
Yasar Meric
YM
Department of Endodontics, Center of Dental Sciences, Gulhane School of Medicine, Ankara, Turkey.
Aydin
Cumhur
C
Ozen
Tuncer
T
Seyrek
Melik
M
Ulusoy
Hasan Basri
HB
Yildiz
Oguzhan
O
D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000502:physiology; D017610:Calcium Compounds / Q000494:pharmacology*; D003785:Dental Pulp Capping / Q000379:methods*; D004338:Drug Combinations; D005260:Female; D023421:Models, Animal; D010087:Oxides / Q000494:pharmacology*; D051381:Rats; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D017640:Silicates / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects* / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology*