title: Hemoglobin Rainier (beta145 Tyrosine rarr Histidine): Alkali-Resistant Hemoglobin with Increased Oxygen Affinity.
abstract: Hemoglobin Rainier, a new hemoglobin variant associated with erythrocytosis, was found in six members of a Caucasiant family. Structurally, it represents substitution of histidine for the invariant residute H23 tyrosine in the beta-hemoglobin polypeptide chain (beta(145) tyrosine --> histidine). Hemoglobin Rainier is the first example of a single amino acid substitution in adult human hemoglobin, causing increased resistance to alkali denaturation.
authors.forename: G
authors.initials: G
authors.lastname: Stamatoyannopoulos
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
authors.forename: J
authors.initials: J
authors.lastname: Adamson
authors.forename: S
authors.initials: S
authors.lastname: Heinenberg