Design and synthesis of cellulose derivatives with antioxidant activity.
In this study we report the synthesis and characterisation of cellulose ferulate, lipoate and alpha-tocopherulate, and their ability to inhibit lipid peroxidation in rat-liver microsomal membranes, induced in vitro by two different sources of free radicals: tert-butyl hydroperoxide and 2,2'-azobis-(2-amidinopropane). We also compared the antioxidant efficiency of the ferulate derivatives obtained through two different synthetic runs, and of a tocopherulate derivative prepared from 6-carboxycellulose. This study showed that the designed systems, preserving the antioxidant activity of the free substrates, are more effective in protecting from tert-butyl hydroperoxide than from 2,2'-azobis-(2-amidinopropane). Moreover, the cellulose ferulate with the higher degree of substitution acted as the best antioxidant.
Trombino
Sonia
S
Department of Pharmaceutical Sciences, University of Calabria, 87036 Arcavacata di Rende, Cosenza, Italy.
Cassano
Roberta
R
Bloise
Ermelinda
E
Muzzalupo
Rita
R
Leta
Sonia
S
Puoci
Francesco
F
Picci
Nevio
N
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis*; D002482:Cellulose / Q000138:chemical synthesis*; D003373:Coumaric Acids / Q000737:chemistry*; D005609:Free Radicals / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D051381:Rats; D008063:Thioctic Acid / Q000737:chemistry*; D024502:alpha-Tocopherol / Q000737:chemistry*; D020122:tert-Butylhydroperoxide