Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin.
Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of MX and citric acid, resulting to an 18 wt% increase of the supports. MX grafted membrane could capture 103 mg/g chlorhexidin digluconate (DigCHX) instead of 1mg/g for a virgin membrane. A neutralization step was performed before the biological tests. Viability tests confirmed the non-toxicity of the MX polymer coating after neutralisation. In vitro release test in human plasma, and microbiological tests showed that membranes grafted with MX were more performing compared to virgin and beta-CD grafted membranes. The antimicrobial activity was effective during more than 72 h.
Tabary
N
N
Laboratoire de Chimie Organique et Macromoléculaire, Université des Sciences et Technologies de Lille, UMR CNRS 8009, 59655 Villeneuve d'Ascq Cedex, France.
Lepretre
S
S
Boschin
F
F
Blanchemain
N
N
Neut
C
C
Delcourt-Debruyne
E
E
Martel
B
B
Morcellet
M
M
Hildebrand
H F
HF
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D019343:Citric Acid / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems; D016967:Fusobacterium nucleatum / Q000187:drug effects; D006801:Humans; D008567:Membranes, Artificial; D008826:Microbial Sensitivity Tests; D011134:Polysaccharides / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties; D005465:Fluorocarbon Polymers