Imaging in systems biology.
Most systems biology approaches involve determining the structure of biological circuits using genomewide "-omic" analyses. Yet imaging offers the unique advantage of watching biological circuits function over time at single-cell resolution in the intact animal. Here, we discuss the power of integrating imaging tools with more conventional -omic approaches to analyze the biological circuits of microorganisms, plants, and animals.
Megason
Sean G
SG
Beckman Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. megason@hms.harvard.edu
Fraser
Scott E
SE
D000818:Animals; D018407:Bacterial Physiological Phenomena; D002453:Cell Cycle / Q000502:physiology*; D049109:Cell Proliferation; D053263:Gene Regulatory Networks; D023281:Genomics; D007090:Image Interpretation, Computer-Assisted; D008856:Microscopy, Fluorescence / Q000379:methods*; D018715:Microscopy, Video; D018521:Plant Physiological Phenomena; D013171:Spores, Bacterial; D013172:Spores, Fungal; D013194:Staining and Labeling; D049490:Systems Biology; D018511:Systems Integration; D013997:Time Factors; D015003:Yeasts / Q000502:physiology