title: Long-term study on symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients.
abstract: From October 2004 through October 2006 a study was performed to evaluate the prevalence of human Metapneumovirus (hMPV) infection in adult hematopoietic stem cell transplant (HSCT) recipients. Sequential nasopharyngeal aspirates (NPA) were collected independently from respiratory symptoms and evaluated for hMPV-RNA by polymerase chain reaction (PCR) and sequence analysis. Results indicate epidemiological and molecular differences between the 2004-2005 and 2005-2006 periods and that hMPV seems not to symptomatically affect HSCT patients or cause late respiratory sequelae. In addition, data collected suggest a hospital origin of hMPV infection in most HSCT patients during the 2004-2005 period.
authors.affiliation: Dipartimento Scienze Morfologiche Eidologiche e Cliniche, Sezione Microbiologia, Università di Pavia, Italy. mdeb@unipv.it
authors.forename: Maurizia
authors.initials: M
authors.lastname: Debiaggi
authors.forename: Filippo
authors.initials: F
authors.lastname: Canducci
authors.forename: Cristina
authors.initials: C
authors.lastname: Terulla
authors.forename: Michela
authors.initials: M
authors.lastname: Sampaolo
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Marinozzi
authors.forename: Paolo Emilio
authors.initials: PE
authors.lastname: Alessandrino
authors.forename: Anna Amelia
authors.initials: AA
authors.lastname: Colombo
authors.forename: Daniela
authors.initials: D
authors.lastname: Caldera
authors.forename: Letizia Zenone
authors.initials: LZ
authors.lastname: Bragotti
authors.forename: Roberta
authors.initials: R
authors.lastname: Migliavacca
authors.forename: Emanuela
authors.initials: E
authors.lastname: Bianchi
authors.forename: Egidio
authors.initials: E
authors.lastname: Romero
authors.forename: Massimo
authors.initials: M
authors.lastname: Clementi
mesh_terms: D000208:Acute Disease; D000328:Adult; D002353:Carrier State; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008137:Longitudinal Studies; D029121:Metapneumovirus / Q000235:genetics* / Q000302:isolation & purification; D009305:Nasopharynx / Q000821:virology; D018184:Paramyxoviridae Infections / Q000453:epidemiology* / Q000209:etiology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics; D012140:Respiratory Tract Diseases / Q000453:epidemiology* / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012621:Seasons; D017421:Sequence Analysis