Synthesis of polysubstituted imidazo[1,2-a]pyridines via microwave-assisted one-pot cyclization/Suzuki coupling/palladium-catalyzed heteroarylation.
A new and efficient method for the synthesis of 2,3,6-trisubstituted imidazo[1,2-a]pyridine derivatives using a microwave-assisted one-pot, two-step Suzuki/heteroarylation or one-pot, three-step cyclization/Suzuki/heteroarylation was developed. Polysubstituted compounds are obtained in good yield from 2-amino-5-halogenopyridines, 2-halogenocarbonyl derivatives, boronic acids, and heteroaryl bromides.
Koubachi
Jamal
J
Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, BP 6759, 45067 Orléans Cedex 2, France.
El Kazzouli
Saïd
S
Berteina-Raboin
Sabine
S
Mouaddib
Abderrahim
A
Guillaumet
Gérald
G
D003500:Cyclization; D007093:Imidazoles / Q000138:chemical synthesis*; D008872:Microwaves; D010165:Palladium / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis*