title: [Case of intractable ventricula fibrillation by a multicomponent dietary supplement containing ephedra and caffeine overdose].
abstract: Multicomponent dietary supplement containing ephedra and caffeine (DSEC) was widely used for weight loss and energy enhancement. The Food and Drug Administration (FDA) banned the sale of DSEC in 2004 because of side effects such as cardiotoxity. We report a rare case of intractable ventricular fibrillation, requiring frequent defibrillation, by DSEC overdose. The direct cardiotoxity of ephedra, synergistic effect of caffeine and ephedra, and hypokalemia may cause refractory ventricular arrhythmia.
authors.affiliation: Department of Emergency Medicine, National Hospital Organization Disaster Medical Center.
authors.forename: Satoru
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Masato
authors.initials: M
authors.lastname: Homma
authors.forename: Junichi
authors.initials: J
authors.lastname: Inoue
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kato
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Murata
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ogasawara
mesh_terms: D000328:Adult; D002110:Caffeine / Q000009:adverse effects*; D019587:Dietary Supplements / Q000009:adverse effects*; D062787:Drug Overdose; D004357:Drug Synergism; D004554:Electric Countershock; D029789:Ephedra / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000209:etiology; D008012:Lidocaine / Q000627:therapeutic use; D008274:Magnesium / Q000627:therapeutic use; D011744:Pyrimidinones / Q000627:therapeutic use; D014693:Ventricular Fibrillation / Q000209:etiology* / Q000628:therapy