title: Rare HVR1-HCV genotype 1b variants in patients with B non Hodgkin's lymphoma. Comparison with viral sequences detected in cases of lymphoproliferative disorders and B cell compartmentalisation.
abstract: We compared the E2-HVR1 region in HCV-1b positive B-NHL cases from a multicenter study with sequences from studies related to lymphoproliferative disorders and B cell compartmentalisation. We found rare and unique mutations both in B-NHL isolates and in cases with lymphoproliferative disorders and lymphocyte infection. These rare mutations could have an important effect on HVR1 region and, as a consequence, on the binding of E2 on CD81, with a possible implication for both antigenic stimulation and HCV entry. In conclusion, the HCV predominants circulating in B-NHL cases seem to be associated with clonal selection of rare variants.
authors.affiliation: Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune-Mediated Disease, Istituto Superiore di Sanita, Rome.
authors.forename: Stefano
authors.initials: S
authors.lastname: Dettori
authors.forename: Claudio
authors.initials: C
authors.lastname: Argentini
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Marcucci
authors.forename: Enea
authors.initials: E
authors.lastname: Spada
authors.forename: Paola
authors.initials: P
authors.lastname: Chionne
authors.forename: Angela
authors.initials: A
authors.lastname: Candido
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Madonna
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Ciccaglione
authors.forename: Elvira
authors.initials: E
authors.lastname: Bianco
authors.forename: Emilio
authors.initials: E
authors.lastname: Iannitto
authors.forename: Pellegrino
authors.initials: P
authors.lastname: Musto
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Liso
authors.forename: Amalia
authors.initials: A
authors.lastname: De Renzo
authors.forename: Livio
authors.initials: L
authors.lastname: Pagano
authors.forename: Grazia
authors.initials: G
authors.lastname: Nieddu
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pulsoni
authors.forename: Alfonso
authors.initials: A
authors.lastname: Mele
authors.forename: Maria
authors.initials: M
authors.lastname: Rapicetta
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D014644:Genetic Variation; D016174:Hepacivirus / Q000145:classification / Q000235:genetics*; D006526:Hepatitis C / Q000150:complications / Q000821:virology*; D018936:Hepatitis C Antigens / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007558:Italy; D016393:Lymphoma, B-Cell / Q000150:complications / Q000821:virology*; D008969:Molecular Sequence Data; D012641:Selection, Genetic; D013045:Species Specificity; D060225:Tetraspanin 28; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism