The effect of simvastatin on remodelling of the alveolar bone following tooth extraction.
Suppression of residual ridge resorption after tooth extraction is a hot spot in dental research. Recently, simvastatin was reported to influence bone turnover by stimulating bone formation. In this study, the effect of simvastatin application on residual ridge resorption following tooth extraction was investigated. Sixty male Wistar rats were randomly divided into experimental and control groups (n=30). Polylactic acid/polyglycolic acid copolymer carriers, with or without simvastatin, were implanted into extraction sockets of right mandibular incisors. The rats were killed at 1, 2, 4, 8 or 12 weeks after implantation. The relative height of the residual alveolar ridge was significantly greater in the experimental compared to the control group at 2, 4, 8 and 12 weeks. The bone mineral density in the experimental group was significantly higher than that in the control group at 4, 8 and 12 weeks. A larger newly formed bone island was observed in the experimental group at 4 weeks, and higher bone formation rate and quality were found than in the control group at different time points except 1 week. The findings indicate that local application of simvastatin would effectively preserve the residual alveolar bone by promoting bone formation in the extraction socket.
Wu
Z
Z
Department of Prothodontics, School of Stomatology, JiLin University, Changchun 130041, China.
Liu
C
C
Zang
G
G
Sun
H
H
D016301:Alveolar Bone Loss / Q000473:pathology / Q000517:prevention & control*; D000539:Alveolar Process / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D015519:Bone Density / Q000187:drug effects; D016723:Bone Remodeling / Q000187:drug effects*; D004195:Disease Models, Animal; D004337:Drug Carriers; D004343:Drug Implants; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D007180:Incisor / Q000601:surgery; D019344:Lactic Acid / Q000737:chemistry; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000473:pathology; D010012:Osteogenesis / Q000187:drug effects; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects / Q000473:pathology