A new family of histamine H3 receptor antagonists based on a natural product: discovery, SAR, and properties of the series.
Cowart
M
M
Abbott Laboratories, GPRD Neuroscience Research, R4MN, AP9A-216, Abbott Park, IL 60064-6123, USA. marlon.d.cowart@abbott.com
Sun
M
M
Zhao
C
C
Witte
D G
DG
Miller
T R
TR
Krueger
K M
KM
Browman
K
K
Fox
G B
GB
Bennani
Y L
YL
Esbenshade
T A
TA
Hancock
A A
AA
D000470:Alkaloids / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006160:Guanosine Triphosphate / Q000378:metabolism; D017442:Histamine Agonists / Q000378:metabolism; D006633:Histamine Antagonists / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008297:Male; D015394:Molecular Structure; D051381:Rats; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D013329:Structure-Activity Relationship