[Recovery of peripheral blood lymphocytes in patients with hematological diseases after allogenic non-relative transplantation of hemopoietic stem cells].
OBJECTIVE
To define impact of lymphopoiesis state on the results of transplantation of hemopoietic stem cells (THSC) by assessment of kinetics of lymphocyte count recovery in early posttransplantation period; to study correlation between THSC results and changes in composition of lymphocyte subpopulation.


METHODS
Recipients of 122 non-relative THSC entered the trial. The recipients were adults with various hematological malignancies.


RESULTS
Allogenic non-relative THSC leads to deep and long-lasting lymphopenia, low count of all lymphocyte subpopulations and, as a result, to marked impairment of antiinfectious and antitumor immune response. Kinetics of lymphopoiesis recovery depended on some clinical factors. Of most importance were duration of the disease before THSC, HLA donor and recipient compatibility, the source of stem cells, lymphocyte count in the transplant, administration of immunosuppressive drugs. Conduction of non-myeloablative regimens of conditioning did not reduce severity and duration of lymphopoiesis suppression. The time of lymphoid subpopulations count recovery had a significant influence on THSC results. Long-term lymphopenia increased the risk of severe infectious complications and recurrence. Low (under 500 lymphocytes in 1 mcl) lymphocyte level in peripheral blood one month after the transplantation was a death risk factor for patients after THSC.


CONCLUSIONS
Dynamics of the recovery of lymphocyte subpopulations can be used for formulating policy of adaptive immunotherapy in patients after THSC.
Vavilov
V N
VN
Zander
A R
AR
Afanas'iev
B V
BV
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D019337:Hematologic Neoplasms / Q000601:surgery*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016219:Immunotherapy, Adoptive; D018655:Lymphocyte Count; D008214:Lymphocytes; D008231:Lymphopenia / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D038041:Lymphopoiesis; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D014184:Transplantation, Homologous