title: Impact of smoking and thiocyanate on perchlorate and thyroid hormone associations in the 2001-2002 national health and nutrition examination survey.
abstract: BACKGROUND
  Findings from a recent large study suggest that perchlorate at commonly occurring exposure concentrations may decrease thyroid hormone levels in some women. Decreases in thyroid hormone seen with perchlorate exposure could be even greater in people with concomitant exposure to agents such as thiocyanate that may affect the thyroid by mechanisms similar to those of perchlorate.
  
  
  OBJECTIVE
  We used data from the National Health and Nutrition Examination Survey to assess the impact of smoking and thiocyanate on the relationship between urinary per-chlorate and serum thyroxine (T(4)) and thyroid-stimulating hormone (TSH).
  
  
  RESULTS
  In women with urinary iodine levels < 100 microg/L, the association between the logarithm of perchlorate and decreased T(4) was greater in smokers [regression coefficient (beta) = -1.66, p = 0.0005] than in nonsmokers (beta = -0.54, p = 0.04). In subjects with high, medium, and low cotinine levels, these regression coefficients were -1.47 (p = 0.0002), -0.57 (p = 0.03), and -0.16 (p = 0.59). For high, medium, and low thiocyanate tertiles they were -1.67 (p = 0.0009), -0.68 (p = 0.09), and -0.49 (p = 0.11). Clear interactions between perchlorate and smoking were not seen with TSH or with T(4) in women with urinary iodine levels > or = 100 microg/L or in men.
  
  
  CONCLUSIONS
  These results suggest that thiocyanate in tobacco smoke and perchlorate interact in affecting thyroid function, and this effect can take place at commonly occurring perchlorate exposures. Agents other than tobacco smoke might cause similar interactions, and further research on these agents could help identify people who are particularly susceptible to perchlorate.
authors.affiliation: Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, California 94612, USA. csteinmaus@oehha.ca.gov
authors.forename: Craig
authors.initials: C
authors.lastname: Steinmaus
authors.forename: Mark D
authors.initials: MD
authors.lastname: Miller
authors.forename: Robert
authors.initials: R
authors.lastname: Howd
mesh_terms: D003367:Cotinine / Q000652:urine; D003404:Creatinine / Q000652:urine; D004785:Environmental Pollutants / Q000633:toxicity* / Q000652:urine; D005260:Female; D006801:Humans; D007455:Iodine / Q000652:urine*; D008297:Male; D009749:Nutrition Surveys; D010472:Perchlorates / Q000633:toxicity* / Q000652:urine; D012907:Smoking / Q000009:adverse effects* / Q000378:metabolism; D013861:Thiocyanates / Q000633:toxicity* / Q000652:urine; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood*