title: Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.
abstract: Noncoding RNA (ncRNA) transcripts are thought to be involved in human tumorigenesis. We report that a large fraction of genomic ultraconserved regions (UCRs) encode a particular set of ncRNAs whose expression is altered in human cancers. Genome-wide profiling revealed that UCRs have distinct signatures in human leukemias and carcinomas. UCRs are frequently located at fragile sites and genomic regions involved in cancers. We identified certain UCRs whose expression may be regulated by microRNAs abnormally expressed in human chronic lymphocytic leukemia, and we proved that the inhibition of an overexpressed UCR induces apoptosis in colon cancer cells. Our findings argue that ncRNAs and interaction between noncoding genes are involved in tumorigenesis to a greater extent than previously thought.
authors.affiliation: Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
authors.forename: Chang-gong
authors.initials: CG
authors.lastname: Liu
authors.forename: Manuela
authors.initials: M
authors.lastname: Ferracin
authors.forename: Terry
authors.initials: T
authors.lastname: Hyslop
authors.forename: Riccardo
authors.initials: R
authors.lastname: Spizzo
authors.forename: Cinzia
authors.initials: C
authors.lastname: Sevignani
authors.forename: Muller
authors.initials: M
authors.lastname: Fabbri
authors.forename: Amelia
authors.initials: A
authors.lastname: Cimmino
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Lee
authors.forename: Sylwia E
authors.initials: SE
authors.lastname: Wojcik
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Shimizu
authors.forename: Esmerina
authors.initials: E
authors.lastname: Tili
authors.forename: Simona
authors.initials: S
authors.lastname: Rossi
authors.forename: Cristian
authors.initials: C
authors.lastname: Taccioli
authors.forename: Flavia
authors.initials: F
authors.lastname: Pichiorri
authors.forename: Xiuping
authors.initials: X
authors.lastname: Liu
authors.forename: Simona
authors.initials: S
authors.lastname: Zupo
authors.forename: Vlad
authors.initials: V
authors.lastname: Herlea
authors.forename: Laura
authors.initials: L
authors.lastname: Gramantieri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lanza
authors.forename: Hansjuerg
authors.initials: H
authors.lastname: Alder
authors.forename: Laura
authors.initials: L
authors.lastname: Rassenti
authors.forename: Stefano
authors.initials: S
authors.lastname: Volinia
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Schmittgen
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Kipps
authors.forename: Massimo
authors.initials: M
authors.lastname: Negrini
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Croce
mesh_terms: D001483:Base Sequence; D002277:Carcinoma / Q000235:genetics*; D016000:Cluster Analysis; D017124:Conserved Sequence; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D035683:MicroRNAs / Q000502:physiology; D008969:Molecular Sequence Data; D009857:Oncogenes / Q000502:physiology; D022661:RNA, Untranslated / Q000737:chemistry*; D017423:Sequence Analysis, RNA