title: Human cytomegalovirus is present in odontogenic cysts.
abstract: BACKGROUND
  Recent studies suggest that some viruses, including human cytomegalovirus (CMV), may be involved in the pathogenesis of periapical lesions. Since periapical cysts (PCs) represent the next stage in the evolution of periapical granuloma, it seemed reasonable to investigate the presence of CMV in PCs and any possible relationship between its presence and the clinical features of those cysts, as well as to compare the results obtained with corresponding findings in non-inflammatory lesions, like odontogenic keratocysts (OKCs).
  
  
  METHODS
  Samples of 33 PCs and 10 OKCs, obtained at the time of surgery, were used for the detection of CMV DNA by polymerase chain reaction. Presence of the virus was correlated with clinical and radiographic features of the cysts.
  
  
  RESULTS
  CMV was detected in 18 PCs (54.5%) and six OKCs (60%). The presence of CMV was more frequent in cyst samples collected from patients who reported previous episodes of acute infection. The presence of sinus tract was more frequent in CMV-positive cysts and CMV presence was less frequent in a group of cysts showing signs of acute inflammation at the time of sample collection. The mean sizes of CMV-positive and CMV-negative PCs were almost the same; CMV-positive OKCs were slightly larger than CMV-negative OKCs. None of these results proved to be statistically significant.
  
  
  CONCLUSIONS
  The presence of CMV in the cystic wall is a common feature of both inflammatory and non-inflammatory odontogenic cysts. Although this study has not proved that CMV affects pathogenesis of odontogenic cysts, such a possibility could not be ruled out.
authors.affiliation: Clinic of Oral Surgery, School of Dentistry, University of Belgrade, Belgrade, Serbia. miroslav.andric@stomf.bg.ac.yu
authors.forename: M
authors.initials: M
authors.lastname: Andric
authors.forename: J
authors.initials: J
authors.lastname: Milasin
authors.forename: T
authors.initials: T
authors.lastname: Jovanovic
authors.forename: L
authors.initials: L
authors.lastname: Todorovic
mesh_terms: D000328:Adult; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D003751:Dental Fistula / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000821:virology; D008439:Maxillary Diseases / Q000821:virology; D009807:Odontogenic Cysts / Q000473:pathology / Q000821:virology*; D010485:Periapical Periodontitis / Q000821:virology; D016133:Polymerase Chain Reaction; D011842:Radicular Cyst / Q000473:pathology / Q000821:virology*