title: Sequential development of long-term potentiation and depression in different layers of the mouse visual cortex.
abstract: Visual deprivation affects the responses of layer IV cells more prominently during early postnatal development, whereas responses in layer II/III remain modifiable until later ages. We examined whether these laminar differences correlate with changes in long-term potentiation (LTP) and long-term depression (LTD) of the ascending pathways to layers IV and II/III in the mouse visual cortex. Our analysis revealed that LTP and LTD in layer IV principal cells is lost shortly after the eyes open, but persists in layers II/III beyond puberty. These results suggest that plasticity proceeds sequentially through cortical layers in a manner that parallels the flow of information during sensory processing.
authors.affiliation: Mind/Brain Institute and Department of Neurosciences, Johns Hopkins University, Baltimore, Maryland 21218, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Jiang
authors.forename: Mario
authors.initials: M
authors.lastname: Treviño
authors.forename: Alfredo
authors.initials: A
authors.lastname: Kirkwood
mesh_terms: D000367:Age Factors; D000818:Animals; D003423:Critical Period, Psychological; D004558:Electric Stimulation; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity / Q000502:physiology; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000502:physiology; D012741:Sexual Maturation / Q000502:physiology; D013997:Time Factors; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology