Modeling energy expenditure and oxygen consumption in human exposure models: accounting for fatigue and EPOC.
Human exposure and dose models often require a quantification of oxygen consumption for a simulated individual. Oxygen consumption is dependent on the modeled individual's physical activity level as described in an activity diary. Activity level is quantified via standardized values of metabolic equivalents of work (METS) for the activity being performed and converted into activity-specific oxygen consumption estimates. However, oxygen consumption remains elevated after a moderate- or high-intensity activity is completed. This effect, which is termed excess post-exercise oxygen consumption (EPOC), requires upward adjustment of the METS estimates that follow high-energy expenditure events, to model subsequent increased ventilation and intake dose rates. In addition, since an individual's capacity for work decreases during extended activity, methods are also required to adjust downward those METS estimates that exceed physiologically realistic limits over time. A unified method for simultaneously performing these adjustments is developed. The method simulates a cumulative oxygen deficit for each individual and uses it to impose appropriate time-dependent reductions in the METS time series and additions for EPOC. The relationships between the oxygen deficit and METS limits are nonlinear and are derived from published data on work capacity and oxygen consumption. These modifications result in improved modeling of ventilation patterns, and should improve intake dose estimates associated with exposure to airborne environmental contaminants.
Isaacs
Kristin
K
Alion Science and Technology Inc., Research Triangle Park, North Carolina 27709, USA. kisaacs@alionscience.com
Glen
Graham
G
Mccurdy
Thomas
T
Smith
Luther
L
D016902:Air Pollution, Indoor / Q000009:adverse effects*; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D004781:Environmental Exposure / Q000009:adverse effects*; D015444:Exercise / Q000502:physiology; D005221:Fatigue; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D008954:Models, Biological; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014691:Ventilation