[The hemodynamics of the eye and the biochemical parameters in patients with hypertensive disease].
Systemic, cerebral, and orbital hemodynamics and the levels of lipids, superoxide dismutase (SOD), and glycated hemoglobin (HbA(1c)) were studied in 324 patients with hypertensive disease (HD). Patients with grades 1 and 2 HD were found to present eye abnormalities as retinal angiopathy (87.3%), chronic optic neuropathy (8.3%), macular dystrophy (2.4%), and sequels of thrombosis of the central retinal vein or its branches (1.9%). The authors identified hypercholesterolemia, a 12% reduction in SOD, and a 7% increase in HbA(1c); in early-stage ophthalmopathology - in retinal angiopathy, as well as in macular dystrophy, the blood levels of cholesterol was 1.5 times greater that the normal values, SOD and HbA(1c) were decreased by 40 and 54%, respectively, along with reduced linear blood flow velocity in the central retinal artery. The decreased index of cerebrovascular vasomotor responsiveness by the ischemic and dyscirculatory type plays an important part in the development of optic neuropathy.
Abdulaeva
M A
MA
Dolzhich
G I
GI
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D005123:Eye / Q000098:blood supply* / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008055:Lipids / Q000097:blood; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D011379:Prognosis; D012171:Retinal Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013482:Superoxide Dismutase / Q000097:blood; D018616:Ultrasonography, Doppler, Duplex