Inactivation of Penicillins G and K by Liver and Kidney.
The inactivation of penicillin K is more rapid in the renal-ligated rabbit than in the renal-ligated, eviscerate preparation. Inactivation of penicillin K occurs in the presence of surviving liver and kidney slices. Small amounts of penicillin G were inactivated by liver slices; larger amounts disappeared in the presence of kidney slices. The inactivation of penicillin K in the presence of rabbit liver and kidney slices is demonstrable anaerobically as well as aerobically.
Tepperman
J
J
Rakieten
N
N
Valley
G
G
Lyon
E W
EW
D000818:Animals; D007668:Kidney; D008099:Liver; D010400:Penicillin G; D010406:Penicillins / Q000378:metabolism*; D011817:Rabbits