Agents affecting lipid metabolism. XXVI. Specificity of some inhibitors of the late stages of cholesterol biosynthesis.
The capacity of 22,25-DAC, AY-9944 and triparanol to inhibit cholesterol biosynthesis from three precursors, mevalonate, 7-dehydrocholesterol and desmosterol, has been studied in rat liver homogenates.Evidence is presented that, in vitro, 22,25-DAC, a potent inhibitor of the sterol Delta(24)-reductase, also inhibits the 7-dehydrocholesterol-Delta(7)-reductase system.
Kraml
M
M
Department of Biochemistry, Ayerst Research Laboratories, Montreal, Canada.
Dubuc
J
J
Dvornik
D
D