title: An unsaturated phosphonic acid analogue of phosphatidylethanolamine and its activity in blood-clotting systems.
abstract: An unsaturated phosphonolipid analogous to phosphatidylethanolamine,rac-dioleoylglyceryl(2-aminoethyl)phosphonate, was synthesized by a general method introduced by Baer for similar saturated substances. An improvement was made in the preparation of the phthalimidoethyl-phosphonic acid precursor.The phosphonolipid was purified by DEAE cellulose and silicic acid chromatography. It was tested by comparison with synthetic phosphatidyl (dioleoyl) ethanolamine and phosphatidyl(dilinoleoyl) ethanolamine in the Hicks-Pitney test and in a test for prothrombin conversion by using purified blood coagulation factors. In both tests it had more acceleratory activity than the synthetic phosphatidylethanolamines.
authors.affiliation: Cardeza Foundation, Jefferson Medical College, 19107, Philadelphia, Pennsylvania.
authors.forename: D L
authors.initials: DL
authors.lastname: Turner
authors.forename: M J
authors.initials: MJ
authors.lastname: Silver
authors.forename: R R
authors.initials: RR
authors.lastname: Holburn
authors.forename: E
authors.initials: E
authors.lastname: Baczynski
authors.forename: A B
authors.initials: AB
authors.lastname: Brown