title: Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD.
abstract: In postmenopausal women with a wide range of vertebral deformities, MRI-based structural measures of topology and scale at the distal radius are shown to account for as much as 30% of vertebral deformity, independent of integral vertebral BMD.
  
  
  BACKGROUND
  Trabecular bone architecture has been postulated to contribute to overall bone strength independent of vertebral BMD measured by DXA. However, there has thus far been only sparse in vivo evidence to support this hypothesis.
  
  
  METHODS
  Postmenopausal women, 60-80 yr of age, were screened by DXA, and those with T-scores at either the hip or spine falling within the range of -2.5 +/- 1.0 were studied with the MRI-based virtual bone biopsy, along with heel broadband ultrasound absorption and pQCT of the tibia. The data from 98 subjects meeting the enrollment criteria were subjected to microMRI at the distal tibia and radius, and measures of topology and scale of the trabecular bone network were computed. A spinal deformity index (SDI) was obtained from morphometric measurements in midline sagittal MR images of the thoracic and lumbar spine to evaluate associations between structure and deformity burden.
  
  
  RESULTS
  A number of structural indices obtained at the distal radius were correlated with the SDI. Among these were the topological surface density (a measure of trabecular plates) and trabecular bone volume fraction, which were inversely correlated with SDI (p < 0.0001). Combinations of two structural parameters accounted for up to 30% of the variation in SDI (p < 0.0001) independent of spinal BMD, which was not significantly correlated. pQCT trabecular BMD was also weakly associated, whereas broadband ultrasound absorption was not. No significant association between SDI and structural indices were found at the tibia.
  
  
  CONCLUSIONS
  Structural measures at the distal radius obtained in vivo by microMRI explained a significant portion of the variation in total spinal deformity burden in postmenopausal women independent of areal BMD.
authors.affiliation: Division of Renal, Electrolytes and Hypertension, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA.
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Ladinsky
authors.forename: Branimir
authors.initials: B
authors.lastname: Vasilic
authors.forename: Andra M
authors.initials: AM
authors.lastname: Popescu
authors.forename: Michael
authors.initials: M
authors.lastname: Wald
authors.forename: Babette S
authors.initials: BS
authors.lastname: Zemel
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Snyder
authors.forename: Louise
authors.initials: L
authors.lastname: Loh
authors.forename: Hee Kwon
authors.initials: HK
authors.lastname: Song
authors.forename: Punam K
authors.initials: PK
authors.lastname: Saha
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Wright
authors.forename: Felix W
authors.initials: FW
authors.lastname: Wehrli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000473:pathology*; D017698:Postmenopause; D011884:Radius / Q000473:pathology*; D013131:Spine / Q000473:pathology*; D013977:Tibia / Q000473:pathology*