Prevalence and factors associated with dyslipoproteinemias in Brazilian systemic lupus erythematosus patients.
To determine the prevalence of dyslipoproteinemias and their related factors in a Brazilian systemic lupus erythematosus (SLE) population, fasting lipids were measured in 185 female SLE outpatients. Age, BMI, smoking, post-menopausal status, presence of diabetes and hypertension, SLE duration, number of ARA criteria, drug treatment and disease activity (by SLEDAI) were registered. Statistics included uni and multivariate logistic regression. Eighty-nine patients (48.1%) had hypercholesterolemia, 55 (29.7%) had hypertriglyceridemia and 109 (58.9%) had either. On multivariate analysis, 24-h proteinuria (OR = 2.08, 95% CI: 1.11-3.88), BMI (OR = 1.08, 95% CI: 1.01-1.16) and post-menopausal status (OR = 2.48, 95% CI: 1.25-4.92) were associated with hypercholesterolemia. Disease activity was related to low HDL-cholesterol (OR = 2.59, 95% CI: 1.20-5.58) and, in pre-menopausal patients, also to hypertriglyceridemia (OR = 1.16, 95% CI: 1.03-1.30). Antimalarial use was protective for hypertriglyceridemia (OR = 0.44, 95% CI: 0.22-0.90). In conclusion, the increased prevalence of dyslipoproteinemias is due to proteinuria, obesity and SLE activity. Antimalarials have beneficial effect on lipid profile that may be due to reduction in disease activity.
Cardoso
Claudia R L
CR
Department of Internal Medicine, Clementino Fraga Filho University Hospital, Medical School, Federal University of Rio de Janeiro, Rua Cróton, 72, Jacarepagua, CEP 22750-240, Rio de Janeiro, Brazil. claudiacardoso@hucff.ufrj.br
Signorelli
Flávio V
FV
Papi
Jose A
JA
Salles
Gil F
GF
D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000208:ethnology* / Q000209:etiology* / Q000517:prevention & control; D015228:Hypertriglyceridemia / Q000208:ethnology* / Q000209:etiology* / Q000517:prevention & control; D016015:Logistic Models; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000208:ethnology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000208:ethnology; D016017:Odds Ratio; D017698:Postmenopause / Q000208:ethnology; D015995:Prevalence; D011507:Proteinuria / Q000150:complications / Q000208:ethnology; D018570:Risk Assessment; D012307:Risk Factors