title: Clinical improvement of diffuse lymphangiomatosis with pegylated interferon alfa-2b therapy: case report and review of the literature.
abstract: Diffuse lymphangiomatosis is a very rare congenital disease, characterized by diffuse or multifocal lymphangioma in the skeletal tissue, spleen, liver, mediastinum, and/or lung. The prognosis is usually poor, especially for children with thoracic lesion, and treatments for the disease are controversial. The authors report a 9-year-old boy with diffuse lymphangiomatosis involving the thorax with pleural effusions, the spleen, and systemic bone. The patient was treated with pegylated interferon alfa-2b, and achieved good clinical and radiological improvement.
authors.affiliation: Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan. mi_ti_ti_1227@yahoo.co.jp
authors.forename: Michio
authors.initials: M
authors.lastname: Ozeki
authors.forename: Michinori
authors.initials: M
authors.lastname: Funato
authors.forename: Kaori
authors.initials: K
authors.lastname: Kanda
authors.forename: Masahumi
authors.initials: M
authors.lastname: Ito
authors.forename: Takahide
authors.initials: T
authors.lastname: Teramoto
authors.forename: Hideo
authors.initials: H
authors.lastname: Kaneko
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fukao
authors.forename: Naomi
authors.initials: N
authors.lastname: Kondo
mesh_terms: D002648:Child; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D008202:Lymphangioma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D011092:Polyethylene Glycols; D011859:Radiography; D011994:Recombinant Proteins; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism