title: [Investigating the possibility of aerosol therapy individualization using the stochastic lung model].
abstract: The aim of our study is to examine the possibility of individualizing aerosol therapy, by determining the ideal diameter of the inhaled particles and the optimal breathing pattern, using a computerized simulation program. In order to find the optimal breathing pattern, we used different variations of the tidal volume and breathing period. We tried to determine the ideal particle diameter by carrying out a series of simulations for particles with diameters ranging from 1 to 10 microns. Our results show that increasing the particle diameter will lead to higher deposition values in the upper respiratory regions and bronchi, and smaller values in the acinary regions of the lung. Repeated simulations have led to two different ideal particle diameters, according to the localization of the desired effect. This way, for the bronchial regions the ideal particle diameter is 10 microns, and for the acinary regions 2 microns.
authors.affiliation: Universitatea de Medicină şi Farmacie Tŝirgu Mureş, Facultatea de Medicină, Spitalul Clinic Judeţecan Mureş Târgu Mureş.
authors.forename: Klara
authors.initials: K
authors.lastname: Brâzaniuc
authors.forename: Z
authors.initials: Z
authors.lastname: Sárkány
authors.forename: Sanda Maria
authors.initials: SM
authors.lastname: Copotoiu
authors.forename: M
authors.initials: M
authors.lastname: Măruşteri
authors.forename: L
authors.initials: L
authors.lastname: Azamfirei
authors.forename: Boér
authors.initials: B
authors.lastname: Kinga
authors.forename: I
authors.initials: I
authors.lastname: Balásházy
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000627:therapeutic use; D003198:Computer Simulation; D004867:Equipment Design; D006801:Humans; D010316:Particle Size; D012138:Respiratory Therapy / Q000379:methods*; D012140:Respiratory Tract Diseases / Q000628:therapy; D013269:Stochastic Processes; D013990:Tidal Volume