Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with adenocarcinoma of the gastroesophageal junction.
Anti-Yo-associated paraneoplastic cerebellar degeneration is a cancer-related syndrome affecting the nervous system. This syndrome occurs almost exclusively in middle-aged women with gynecological cancers and it is rarely found in patients with other types of cancer or in males. In this report we describe a male patient adenocarcinoma of the gastroesophageal junction and PCD with anti-Yo antibodies. To our knowledge, this is only the third report of PCD with positive anti-Yo antibodies in an esophageal tumor and the first report in a tumor of the gastroesophageal junction.
Debes
J D
JD
Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Lagarde
S M
SM
Hulsenboom
E
E
Sillevis Smitt
P A E
PA
ten Kate
F J W
FJ
Sulter
G A
GA
van Lanschot
J J B
JJ
D000230:Adenocarcinoma / Q000276:immunology* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000276:immunology* / Q000473:pathology; D004943:Esophagogastric Junction; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D020362:Paraneoplastic Cerebellar Degeneration / Q000276:immunology* / Q000473:pathology