title: Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis.
abstract: Bioassay-guided fractionation of an active fraction from an extract of a marine starfish, Novodinia antillensis, led to the isolation and identification of two new saponins, Sch 725737 (1) and Sch 725739 (2). Compound 1 was identified as the NaV1.8 inhibitor with IC(50) of approximately 9 microM. The purification and the structure elucidation of these two saponins are described.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. shu-wei.yang@spcorp.com
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Yang
authors.forename: Tze-Ming
authors.initials: TM
authors.lastname: Chan
authors.forename: Alexei
authors.initials: A
authors.lastname: Buevich
authors.forename: Tony
authors.initials: T
authors.lastname: Priestley
authors.forename: James
authors.initials: J
authors.lastname: Crona
authors.forename: John
authors.initials: J
authors.lastname: Reed
authors.forename: Amy E
authors.initials: AE
authors.lastname: Wright
authors.forename: Mahesh
authors.initials: M
authors.lastname: Patel
authors.forename: Vincent
authors.initials: V
authors.lastname: Gullo
authors.forename: Guodong
authors.initials: G
authors.lastname: Chen
authors.forename: Birendra
authors.initials: B
authors.lastname: Pramanik
authors.forename: Min
authors.initials: M
authors.lastname: Chu
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D009682:Magnetic Resonance Spectroscopy; D008564:Membrane Potentials / Q000187:drug effects; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D026941:Sodium Channel Blockers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015222:Sodium Channels / Q000378:metabolism; D013215:Starfish / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology