Cerebrospinal fluid penetration and bacteriostatic activity of linezolid against Enterococcus faecalis in a child with a ventriculoperitoneal shunt infection.
We report a 4-year-old girl with a complicated Enterococcus faecalis ventriculoperitoneal shunt infection who failed vancomycin therapy. We demonstrate linezolid's high CSF penetration and its CSF bacteriostatic activity against E. faecalis. Linezolid may be a good alternative for treatment of ventriculoperitoneal shunt infections in cases of vancomycin-resistant organisms or apparent treatment failures.
Milstone
Aaron M
AM
Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA. amilsto1@jhmi.edu
Dick
James
J
Carson
Benjamin
B
Siberry
George K
GK
D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D000069349:Linezolid; D023303:Oxazolidinones / Q000494:pharmacology / Q000627:therapeutic use*; D017287:Ventriculoperitoneal Shunt / Q000009:adverse effects*