Mitochondria on the move.
Interactions of mitochondria with the cytoskeleton are crucial for normal mitochondrial function and for localization of the organelle at its sites of action within cells. Early studies revealed a role for microtubule motors in mitochondrial motility in neurons and other cell types. Here, we describe advances in our understanding of mitochondrial movement and distribution. Specifically, we review recent studies on proteins that mediate or regulate the interaction between motor molecules and the organelle, motor-independent mechanisms for mitochondrial motility, anchorage of mitochondria at cortical sites within cells and links between mitochondria-cytoskeleton interactions and mitochondrial plasticity.
Boldogh
Istvan R
IR
Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, 1130 St. Nicholas Avenue, Room 311B, New York, NY 10032, USA.
Pon
Liza A
LA
D000199:Actins / Q000378:metabolism; D000818:Animals; D001370:Axonal Transport; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D016547:Kinesins / Q000378:metabolism; D008561:Membrane Fusion; D008928:Mitochondria / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism*; D020409:Molecular Motor Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D015398:Signal Transduction