Functional genomics approaches to studies of the cytochrome p450 superfamily.
Functional genomics approaches are widely implemented in current research and have found application in many areas of biology. This review will present research fields, novel findings and new tools developed in the cytochrome P450 field using the functional genomics techniques. The most widely used method is microarray technology, which has already greatly contributed to the understanding of the cytochromes P450 function and expression. Several focused CYP microarrays have been developed for genotyping, toxicogenomics and studies of CYP function of many different organisms. Our contribution to the CYP field by development of Steroltalk microarrays to study the cross-talk of cholesterol homeostasis and drug metabolism is also presented.
Rezen
Tadeja
T
Center for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Contreras
Juan A
JA
Rozman
Damjana
D
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D020869:Gene Expression Profiling; D023281:Genomics; D005838:Genotype; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis