title: Controlled release in transdermal pressure sensitive adhesives using organosilicate nanocomposites.
abstract: Polydimethyl siloxane (PDMS) based pressure sensitive adhesives (PSA) incorporating organo-clays at different loadings were fabricated via solution casting. Partially exfoliated nanocomposites were obtained for the hydroxyl terminated PDMS in ethyl acetate solvent as determined by X-ray diffraction and atomic force microscopy. Drug release studies showed that the initial burst release was substantially reduced and the drug release could be controlled by the addition of organo-clay. Shear strength and shear adhesion failure temperature (SAFT) measurements indicated substantial improvement in adhesive properties of the PSA nanocomposite adhesives. Shear strength showed more than 200% improvement at the lower clay loadings and the SAFT increased by about 21% due to the reinforcement provided by the nano-dispersed clay platelets. It was found that by optimizing the level of the organosilicate additive to the polymer matrix, superior control over drug release kinetics and simultaneous improvements in adhesive properties could be attained for a transdermal PSA formulation.
authors.affiliation: Department of Chemical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-7217, USA.
authors.forename: Sohel
authors.initials: S
authors.lastname: Shaikh
authors.forename: Anil
authors.initials: A
authors.lastname: Birdi
authors.forename: Syed
authors.initials: S
authors.lastname: Qutubuddin
authors.forename: Eric
authors.initials: E
authors.lastname: Lakatosh
authors.forename: Harihara
authors.initials: H
authors.lastname: Baskaran
mesh_terms: D000287:Administration, Topical; D001458:Bandages; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D008422:Materials Testing; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D017646:Organosilicon Compounds / Q000737:chemistry*; D011312:Pressure; D014014:Tissue Adhesives / Q000737:chemistry*