Does epileptiform activity contribute to cognitive impairment in Alzheimer's disease?
Alzheimer's disease is a devastating neurological disorder. The role of hyperexcitability in the disease's cognitive decline is not completely understood. In this issue of Neuron, Palop et al. report both limbic seizures and presumed homeostatic responses to seizures in an animal model of Alzheimer's.
Leonard
A Soren
AS
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
McNamara
James O
JO
D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology*; D018891:Dentate Gyrus / Q000503:physiopathology*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000209:etiology / Q000503:physiopathology*; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics; D009433:Neural Inhibition / Q000235:genetics; D009478:Neuropeptide Y / Q000378:metabolism