Expression of p63 normal canine skin and primary cutaneous glandular carcinomas.
p63, a recently identified homologue of the p53 protein, is expressed consistently in basal cells of several human multilayered epithelia. In this study, expression of p63 was determined in 31 primary cutaneous glandular carcinomas, including sebaceous, perianal (hepatoid) gland, apocrine and ceruminous carcinomas, as well as their adjacent normal skin. Similar to humans, p63 is a reliable marker for basal and myoepithelial cells in canine epidermis, cutaneous appendages and malignant apocrine and ceruminous gland neoplasms. In sebaceous carcinomas, not only basal cells, but also some sebocytes, showed nuclear staining for p63. Most mature epithelial cells in perianal gland carcinomas exhibited strong p63 expression. Based on these findings, basal/myoepithelial cells could be involved in the oncogenesis of these tumours and p63 might be used as a diagnostic marker in these lesions.
Saraiva
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Veterinary Sciences Department, Centre of Animal and Veterinary Sciences (CECAV), Universidade de Trás-os-Montes e Alto Douro (UTAD), 5001-801 Vila Real, Portugal.
Gärtner
F
F
Pires
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MA
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D004283:Dog Diseases / Q000175:diagnosis / Q000378:metabolism*; D004285:Dogs; D004817:Epidermis / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D007150:Immunohistochemistry / Q000662:veterinary; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis / Q000378:metabolism / Q000662:veterinary*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000662:veterinary*; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000378:metabolism*