Requirement of intact sympathetic transmission for the ocular hypotensive effects of melatonin and 5-MCA-NAT.
Melatonin and its analogue, 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT), potently reduce intraocular pressure, and may be good candidates for the treatment of ocular hypertension and glaucoma. After chemical sympathectomy by reserpine or 6-hydroxydopamine, the hypotensive effects of melatonin and 5-MCA-NAT are severely inhibited. This indicates that the sympathetic nervous system is involved in the production and drainage of aqueous humour by the ciliary body and trabecular meshwork, and that it mediates the effects of melatonin and its analogue, 5-MCA-NAT.
Alarma-Estrany
Pilar
P
Departamento de Bioquímica, Universidad Complutense de Madrid, 28037 Madrid, Spain.
Crooke
Almudena
A
Peral
Assumpta
A
Pintor
Jesús
J
D018759:Adrenergic Uptake Inhibitors / Q000009:adverse effects; D000818:Animals; D002492:Central Nervous System Depressants / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D009798:Ocular Hypertension / Q000188:drug therapy*; D016627:Oxidopamine / Q000009:adverse effects; D011817:Rabbits; D012110:Reserpine / Q000009:adverse effects; D013563:Sympathectomy, Chemical / Q000379:methods; D013564:Sympathetic Nervous System / Q000502:physiology*; D013565:Sympatholytics / Q000009:adverse effects; D014363:Tryptamines / Q000627:therapeutic use*; D050493:Vesicular Monoamine Transport Proteins / Q000378:metabolism