title: A fight for neurotransmission: SCRAPPER trashes RIM.
abstract: The presynaptic scaffold molecule RIM1alpha is important for regulating neurotransmitter release. In this issue, Yao et al. (2007) show in mice that an E3 ubiquitin ligase, SCRAPPER, targets a set of presynaptic proteins including RIM1alpha for degradation by the ubiquitin-proteasome system. Their results identify protein degradation as a mechanism for holding rapid synaptic communication in check.
authors.affiliation: Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2B5, Canada.
authors.forename: Frederick
authors.initials: F
authors.lastname: Dobie
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Craig
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D002478:Cells, Cultured; D019706:Excitatory Postsynaptic Potentials; D019204:GTP-Binding Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D005838:Genotype; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D051379:Mice; D018345:Mice, Knockout; D009473:Neuronal Plasticity; D009474:Neurons / Q000201:enzymology / Q000378:metabolism; D010641:Phenotype; D017729:Presynaptic Terminals / Q000201:enzymology / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D012333:RNA, Messenger / Q000378:metabolism; D013569:Synapses / Q000201:enzymology / Q000378:metabolism*; D009435:Synaptic Transmission; D013572:Synaptic Vesicles / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*