title: Cerebrospinal fluid penetration and bacteriostatic activity of linezolid against Enterococcus faecalis in a child with a ventriculoperitoneal shunt infection.
abstract: We report a 4-year-old girl with a complicated Enterococcus faecalis ventriculoperitoneal shunt infection who failed vancomycin therapy. We demonstrate linezolid's high CSF penetration and its CSF bacteriostatic activity against E. faecalis. Linezolid may be a good alternative for treatment of ventriculoperitoneal shunt infections in cases of vancomycin-resistant organisms or apparent treatment failures.
authors.affiliation: Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA. amilsto1@jhmi.edu
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Milstone
authors.forename: James
authors.initials: J
authors.lastname: Dick
authors.forename: Benjamin
authors.initials: B
authors.lastname: Carson
authors.forename: George K
authors.initials: GK
authors.lastname: Siberry
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D000069349:Linezolid; D023303:Oxazolidinones / Q000494:pharmacology / Q000627:therapeutic use*; D017287:Ventriculoperitoneal Shunt / Q000009:adverse effects*