There's more than one way to skin a chimaerin.
In two manuscripts published in Neuron (Beg et al. and Wegmeyer et al.) and one published in Cell (Iwasato et al.), investigators have found that a particular GAP, alpha-chimaerin, is required in vivo for ephrinB3/EphA4-dependent motor circuit formation.
Dalva
Matthew B
MB
Department of Neuroscience, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA. dalva@mail.med.upenn.edu
D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D020848:Chimerin 1 / Q000235:genetics / Q000378:metabolism*; D036389:Ephrin-B3 / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D020439:Growth Cones / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D009046:Motor Neurons / Q000166:cytology / Q000378:metabolism; D009434:Neural Pathways / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D011712:Pyramidal Tracts / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D036122:Receptor, EphA4 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology