title: Feasibility of using interpolated contours of targets and organs at risk in intensity-modulated radiation therapy treatment planning for advanced-stage nasopharyngeal carcinoma.
abstract: To assess the dosimetric effect of using interpolated contours in planning intensity-modulated radiation therapy (IMRT) for advanced T-stage nasopharyngeal carcinoma. The present study focused on T3-T4 tumours where the proximity of targets to neurological organs poses a stringent test on the feasibility of such an approach. Contours of targets and organs were delineated on CT images of 2.5-mm interval and a reference IMRT plan was generated. An investigative (INV) IMRT plan was then generated with the same planning protocol, but based on interpolated contours that replaced deleted contours on alternate slices. The reference and INV plans were compared. Regarding target coverage, all targets in the INV plans met the acceptance criteria except for the PTV in one case. Regarding organs, the mean dose to 1% volume of the brainstem and spinal cord in the INV plans were kept below their dose limits. No significant differences in the mean doses to others organs were found. Satisfactory target coverage and protection of critical organs to a degree similar to full-scale contouring could be achieved with use of interpolated contours. The saving in manpower time for contouring is expected to significantly improve the throughput of the IMRT planning process.
authors.affiliation: Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong SAR. s033928@mailserv.cuhk.edu.hk
authors.forename: M C
authors.initials: MC
authors.lastname: Chau
authors.forename: S F
authors.initials: SF
authors.lastname: Leung
authors.forename: K M
authors.initials: KM
authors.lastname: Kam
authors.forename: K Y
authors.initials: KY
authors.lastname: Cheung
authors.forename: W H
authors.initials: WH
authors.lastname: Kwan
authors.forename: K H
authors.initials: KH
authors.lastname: Yu
authors.forename: K W
authors.initials: KW
authors.lastname: Chiu
authors.forename: T C
authors.initials: TC
authors.lastname: Chan
mesh_terms: D004307:Dose-Response Relationship, Radiation; D005240:Feasibility Studies; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated; D014057:Tomography, X-Ray Computed