[Effects of Rukuaixiao decoction on hyperplasia of mammary gland in rats].
OBJECTIVE
To observe the therapeutic effect of Rukuaixiao decoction (RKX) on hyperplasia of mammary gland in rats.


METHODS
60 SD female rats were radomly divided into blank control group, model group, tamoxifen group and different dose of RKX groups. Injection of estradiol and progesterone were given to establish rat models of mammary gland hyperplasia and RKX was given at the same time. Changes of breast diameter, mammilla height were measured; serum sex hormones levels, blood rheology, SOD activity and MDA content were estimated. Pathologic changes of mammary gland in rats were also observed under light microscope.


RESULTS
RKX could decrease the increased breast diameter, mammilla height, reduce the numbers of mammary gland lobules and relieve the pathologic changes of mammary gland. It could also decrease estradiol, prolactin levels and MDA content in serum, increase the serum progesterone level and inhibit the decrease of the coefficient of thymus.


CONCLUSIONS
Rukuaixiao decoction has the function of treatment on hyperplasia of mammary gland.
Chen
Sha-sha
SS
Institute of Chinese Medicinal Materials, Nanjing Agricultural University, Nanjing 210095, China.
Guo
Qiao-sheng
QS
Jin
Rong
R
Zhou
Fen
F
Wang
Tian
T
D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006965:Hyperplasia; D008315:Malondialdehyde / Q000097:blood; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000473:pathology; D009835:Oligochaeta / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012212:Rheology / Q000187:drug effects; D013482:Superoxide Dismutase / Q000097:blood