5-methyltetrahydrofolic Acid as a mediator in the formation of pyridoindoles.
Enzymes from chick and rat tissues catalyze the reaction of N-methyl tryptamine with 5-methyltetrahydrofolic acid to form 2,3,4,9-tetrahydro-2-methyl-1H-pyrido[3,4b] indole. N,N-Dimethyltryptamine was not formed. With tryptamine as substrate the product is 2,3,4,9-tetrahydro-1H-pyrido[3,4b] indole and not N-methyltryptamine. These pyridoindoles were not formed when S-adenosylmethionine was cosubstrare.
Mandel
L R
LR
Rosegay
A
A
Walker
R W
RW
Vandenheuvel
W J
WJ
Rokach
J
J