title: Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies.
abstract: The effects of cancer treatments such as cranial radiation and chemotherapy on human hippocampal neurogenesis remain unknown. In this study, we examine neuropathological markers of neurogenesis and inflammation in the human hippocampus after treatment for acute myelogenous leukemia or medulloblastoma. We demonstrate a persistent radiation-induced microglial inflammation that is accompanied by nearly complete inhibition of neurogenesis after cancer treatment. These findings are consistent with preclinical animal studies and suggest potential therapeutic strategies.
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA. mmonje@partners.org
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Monje
authors.forename: Hannes
authors.initials: H
authors.lastname: Vogel
authors.forename: Marilyn
authors.initials: M
authors.lastname: Masek
authors.forename: Keith L
authors.initials: KL
authors.lastname: Ligon
authors.forename: Paul G
authors.initials: PG
authors.lastname: Fisher
authors.forename: Theo D
authors.initials: TD
authors.lastname: Palmer
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002454:Cell Differentiation / Q000187:drug effects / Q000528:radiation effects; D002648:Child; D002675:Child, Preschool; D016371:Cranial Irradiation / Q000009:adverse effects; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects*; D006801:Humans; D007223:Infant; D007951:Leukemia, Myeloid / Q000473:pathology / Q000628:therapy*; D008297:Male; D008527:Medulloblastoma / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D011446:Prospective Studies