title: The forest for the trees: a systems approach to human health research.
abstract: We explore the relationship between current research directions in human health and environmental and public health policy. Specifically, we suggest there is a link between the continuing emphasis in biomedical research on individualized, therapeutic solutions to human disease and the increased reliance on individual choice in response to environmental and/or public health threats. We suggest that continued research emphasis on these traditional approaches to the exclusion of other approaches will impede the discovery of important breakthroughs in human health research necessary to understand the emerging diseases of today. We recommend redirecting research programs to interdisciplinary and population-focused research that would support a systems approach to fully identifying the environmental factors that contribute to disease burden. Such an approach would be able to address the interactions between the social, ecological, and physical aspects of our environment and explicitly include these in the evaluation and management of health risks from environmental exposures.
authors.affiliation: Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
authors.forename: Julia M
authors.initials: JM
authors.lastname: Gohlke
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Portier
mesh_terms: D000818:Animals; D004777:Environment; D004782:Environmental Health; D006801:Humans; D011634:Public Health; D011640:Public Policy; D012106:Research; D049490:Systems Biology