Centrioles: duplicating precariously.
To assemble a mitotic spindle and accurately segregate chromosomes to progeny, a cell needs to precisely regulate its centrosome number, a feat largely accomplished through the tight control of centriole duplication. Recent work showing that the overexpression of centriolar proteins can lead to the formation of multiple centrioles in the absence of pre-existing centrioles challenges the idea that it is a self-replicating organelle.
Pelletier
Laurence
L
Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada. pelletier@mshri.on.ca
D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D002502:Centrioles / Q000378:metabolism*; D020090:Chromosome Segregation / Q000502:physiology; D004330:Drosophila / Q000378:metabolism*