Examining initial sleep onset in primary insomnia: a case-control study using 4-second epochs.
OBJECTIVE
To explore the sleep onset process in primary insomnia patients, new rules for scoring 4-second epochs were implemented to score sleep and artifacts during initial sleep onset. Conventional scorings in 20-second and 60-second epochs were also obtained.


METHODS
The start of the initial 60-second epoch of stage 1 was used to define "time zero" (t0). Sleep onset periods from 11 patients and 11 individually age- and sex-matched controls spanned from 5 minutes before t0 through 29 minutes after t0. Using the new rules, the periods were scored blind to group assignment. This t0 time-referenced the data analysis to one plausible midpoint in the sleep onset process. In parallel, latencies were time-referenced from good night time.


RESULTS
Reliability in scoring sleep and artifacts was adequate (kappa = 0.68 & 0.63, respectively, p <0.001). Group differences in sleep latencies were marginal in 60-second and 20-second scoring but significant with a definition of 4-second sleep latency. Patients had more 4-second epochs scored as awake (Mantel-Haenszel chi2 = 271, d.f. = 1, p <0.001) and containing artifact (M-H chi2 = 143, p <0.001). Patients took longer to achieve 30 continuous 4-second epochs of NREM sleep (Breslow chi2 = 4.03, d.f. = 1, p = 0.045) after t0. Patients accumulated sleep more slowly with all 3 scoring rules after t0. A slower rate of accumulating sleep after t0 was detected only with the 4-second scoring (p = 0.047).


CONCLUSIONS
Evidence was present for momentary state-switching instabilities in the patients during the initial sleep onset process. Using rules for scoring small epochs may reveal such instabilities more readily than traditional scoring methods.
Moul
Douglas E
DE
University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA. moulde@upmc.edu
Germain
Anne
A
Cashmere
J David
JD
Quigley
Michael
M
Miewald
Jean M
JM
Buysse
Daniel J
DJ
D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography / Q000379:methods*; D015203:Reproducibility of Results; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis*; D012894:Sleep Stages; D014851:Wakefulness