title: TGF-beta1 suppresses T cell infiltration and VP2 puff B mutation enhances apoptosis in acute polioencephalitis induced by Theiler's virus.
abstract: GDVII and DA strains of Theiler's murine encephalomyelitis virus (TMEV) differ in VP2 puff B. One week after GDVII virus infection, SJL/J mice had large numbers of TUNEL+ apoptotic cells with a relative lack of T cell infiltration in the brain. DA viruses with mutation in puff B induced higher levels of apoptosis than wild-type DA virus, but levels of inflammation in brains were similar between DA and DA virus mutants. The difference in inflammation among TMEVs could be due to TGF-beta1 expression that was seen only in GDVII virus infection and negatively correlated with CD3+ T cell infiltration.
authors.affiliation: Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Tsunoda
authors.forename: Jane E
authors.initials: JE
authors.lastname: Libbey
authors.forename: Robert S
authors.initials: RS
authors.lastname: Fujinami
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000276:immunology; D017252:CD3 Complex / Q000276:immunology; D036022:Capsid Proteins / Q000235:genetics*; D002634:Chemotaxis, Leukocyte / Q000235:genetics / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D020287:In Situ Nick-End Labeling; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D009154:Mutation / Q000235:genetics; D011051:Poliomyelitis / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D013601:T-Lymphocytes / Q000276:immunology*; D017945:Theilovirus / Q000276:immunology*; D053773:Transforming Growth Factor beta1 / Q000276:immunology*