Mouse models of diabetic neuropathy.
Diabetic neuropathy (DN) is a debilitating complication of type 1 and type 2 diabetes. Rodent models of DN do not fully replicate the pathology observed in human patients. We examined DN in streptozotocin (STZ)-induced [B6] and spontaneous type 1 diabetes [B6Ins2(Akita)] and spontaneous type 2 diabetes [B6-db/db, BKS-db/db]. Despite persistent hyperglycemia, the STZ-treated B6 and B6Ins2(Akita) mice were resistant to the development of DN. In contrast, DN developed in both type 2 diabetes models: the B6-db/db and BKS-db/db mice. The persistence of hyperglycemia and development of DN in the B6-db/db mice required an increased fat diet while the BKS-db/db mice developed severe DN and remained hyperglycemic on standard mouse chow. Our data support the hypothesis that genetic background and diet influence the development of DN and should be considered when developing new models of DN.
Sullivan
Kelli A
KA
Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, USA.
Hayes
John M
JM
Wiggin
Timothy D
TD
Backus
Carey
C
Su Oh
Sang
S
Lentz
Stephen I
SI
Brosius
Frank
F
Feldman
Eva L
EL
D000818:Animals; D053938:DNA Fragmentation; D003929:Diabetic Neuropathies / Q000139:chemically induced / Q000145:classification / Q000235:genetics* / Q000503:physiopathology*; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000209:etiology; D020287:In Situ Nick-End Labeling / Q000379:methods; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D016688:Mice, Inbred NOD / Q000235:genetics; D009412:Nerve Fibers / Q000473:pathology; D009431:Neural Conduction / Q000502:physiology; D010147:Pain Measurement; D011930:Reaction Time; D013311:Streptozocin; D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism; D043222:Ubiquitin Thiolesterase / Q000378:metabolism