title: Outcomes of dosage adjustments used to manage antiretroviral drug interactions.
abstract: Dosage adjustments are often used to manage HIV drug interactions, but little is known about their clinical significance. We examined patients from the Ontario HIV Cohort Study to assess the effects of dosage adjustments on plasma viral load. A significant reduction (0.67 log10 copies/mL) in viral load was associated with adjustments to manage efavirenz-based interactions (95% confidence interval, -1.33 to -0.01) but was not observed after adjustments to manage rifabutin-based (difference in viral load, 0.03 log10 copies/mL; 95% confidence interval, -0.71 to 0.77) or nevirapine-based interactions (difference in viral load, 0.09 log10 copies/mL; 95% confidence interval, -0.83 to 1.01).
authors.affiliation: Centre for Research on Inner City Health, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, Canada. parkwylliel@smh.toronto.on.ca
authors.forename: Laura Y
authors.initials: LY
authors.lastname: Park-Wyllie
authors.forename: Mitchell A
authors.initials: MA
authors.lastname: Levine
authors.forename: Anne
authors.initials: A
authors.lastname: Holbrook
authors.forename: Lehana
authors.initials: L
authors.lastname: Thabane
authors.forename: Tony
authors.initials: T
authors.lastname: Antoniou
authors.forename: Deborah
authors.initials: D
authors.lastname: Yoong
authors.forename: Derek
authors.initials: D
authors.lastname: Kam
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Bayoumi
mesh_terms: D044966:Anti-Retroviral Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D009864:Ontario; D016896:Treatment Outcome; D019562:Viral Load