[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance].
OBJECTIVE
To investigate the expression and clinical significance of RAD51 in laryngocarcinoma.


METHODS
The expression of RAD51 in laryngocarcinoma and polyp of vocal cord tissues were determined by immunohistochemical staining. The results were analyzed and compared with the clinical stage, lymph node metastasis and pathologic grade.


RESULTS
(1) The expression of RAD51 in laryngocarcinoma group was extremely stronger than that in polyp of vocal cord group (P < 0.01). (2) There was significant difference for RAD51 expression in cancer cells between earlier clinical stage group and advanced clinical stage group (P < 0.01). (3) There was significant difference for RAD51 expression in different pathologic grades (P < 0.05). (4) There was also significant difference for RAD51 expression between groups with and without lymph node metastasis.


CONCLUSIONS
RAD51 may play a critical role in tumorigenesis of laryngocarcinoma. RAD51 may be a potential marker for clinical diagnosis and treatment of Laryngocarcinoma. It may be significant in predicting clinical stage, pathologic grade and metastasis.
Yao
Wei
W
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Chen
Wei
W
Chen
Shiming
S
Xiao
Bokui
B
Wang
Yan
Y
Tao
Zezhang
Z
D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011127:Polyps / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D051135:Rad51 Recombinase / Q000378:metabolism*; D014827:Vocal Cords / Q000473:pathology