Random plasma concentrations of voriconazole decline over time.
We retrospectively collected information about 29 cancer patients who underwent measurement of their plasma concentration (PC) of voriconazole (VRC) (2002-2006). Nine patients (31%) had VRC PC <1 microg/ml. VRC PC <1 microg/ml occurred in 7 of 10 patients who were on VRC >2 months versus only 2 of 19 patients who were on VRC <2 months (P=0.001). VRC PCs were infrequently ordered, did not follow clear indications, and the use of the results was variable.
Mulanovich
Victor
V
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Lewis
Russell E
RE
Raad
Issam I
II
Kontoyiannis
Dimitrios P
DP
D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D010949:Plasma / Q000737:chemistry*; D011743:Pyrimidines / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012189:Retrospective Studies; D013997:Time Factors; D014230:Triazoles / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D065819:Voriconazole