Oesophageal sarcomas in dogs: histological and clinical evaluation.
A histological grading system of oesophageal sarcomas has not been established. Thirty-two cases of oesophageal sarcomas have been reviewed for tumour characteristics and clinical outcome. Nineteen dogs underwent surgical intervention to remove oesophageal tumours; ten of them survived (median 278 days). Primary tumour types included osteosarcoma (47%), osteosarcoma with tumour giant cells (7%), fibroblastic osteosarcoma (13%), chondroblastic osteosarcoma (7%) fibrosarcoma (23%) and undifferentiated sarcoma (3%). Histological grade evaluation revealed 33% grade 1 sarcoma, 50% grade 2 and 17% grade 3. No correlation could be found between survival and signalment, duration of clinical signs, tumour type, tumour grade and chemotherapy. Chemotherapy was found to reduce lung metastases' histological scores in three cases (P=0.0007). Surgery seems to be the treatment of choice but the effect of chemotherapy warrants further investigation. Additional research of cases should be performed in order to further define prognostic factors of oesophageal sarcomas.
Ranen
Eyal
E
School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel. ranen@agri.huji.ac.il
Dank
Gillian
G
Lavy
Eran
E
Perl
Samuel
S
Lahav
Dan
D
Orgad
Uri
U
D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004938:Esophageal Neoplasms / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008297:Male; D012509:Sarcoma / Q000145:classification / Q000473:pathology / Q000662:veterinary*