title: Four-dimensional magnetic resonance imaging for the determination of tumour movement and its evaluation using a dynamic porcine lung phantom.
abstract: A method of four-dimensional (4D) magnetic resonance imaging (MRI) has been implemented and evaluated. It consists of retrospective sorting and slice stacking of two-dimensional (2D) images using an external signal for motion monitoring of the object to be imaged. The presented method aims to determine the tumour trajectories based on a signal that is appropriate for monitoring the movement of the target volume during radiotherapy such that the radiation delivery can be adapted to the movement. For evaluation of the 4D-MRI method, it has been applied to a dynamic lung phantom, which exhibits periodic respiratory movement of a porcine heart-lung explant with artificial pulmonary nodules. Anatomic changes of the lung phantom caused by respiratory motion have been quantified, revealing hysteresis. The results demonstrate the feasibility of the presented method of 4D-MRI. In particular, it enables the determination of trajectories of periodically moving objects with an uncertainty in the order of 1 mm.
authors.affiliation: Department of Medical Physics in Radiation Oncology, German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Remmert
authors.forename: J
authors.initials: J
authors.lastname: Biederer
authors.forename: F
authors.initials: F
authors.lastname: Lohberger
authors.forename: M
authors.initials: M
authors.lastname: Fabel
authors.forename: G H
authors.initials: GH
authors.lastname: Hartmann
mesh_terms: D000465:Algorithms; D000818:Animals; D016477:Artifacts; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D066298:In Vitro Techniques; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009068:Movement; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine