title: [Methodological studies on equivalent relationship between granule for clinical prescription and clinical decoction of fructus evodiae].
abstract: OBJECTIVE
  To investigate the equivalent relationship between granule for clinical prescription and clincal decoction by use of fructus evodiae as a demonstrated object.
  
  
  METHODS
  Compared the equivalent ratio relationship of granule for clincal prescription and clincal decoction by determination of evodiamine, rutaecarpine, evodine, total alkaloids and dried extract ratio as markers, ten batches reference decoctions were prepared according to clinical usage as evaluation standards, common-use processed fructus evodiae products, such as salt-processed fructus evodiae, liquorice-proccesed fructus evodiae, as researching objects, and finally validated by pharmacological trials.
  
  
  RESULTS
  Equivalent ratios of granule for clical prescription to clincal decoction are about two in all processed products, and the pharmacological evaluation showed no siginificant difference in this ratio.
  
  
  CONCLUSIONS
  This equivalent ratio model could be referenced in the production. But, it must be noticed that different herbal medicines perhaps have different equivalent ratio, which should be studied further according to its techniques and production conditions, and finally need to be revalidated by clinical trial.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. zhmw123@263.net
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Yu-mei
authors.initials: YM
authors.lastname: Hong
authors.forename: Wei-hao
authors.initials: WH
authors.lastname: Wang
authors.forename: Jin-yu
authors.initials: JY
authors.lastname: Wang
authors.forename: Hui-min
authors.initials: HM
authors.lastname: Gao
mesh_terms: D000470:Alkaloids / Q000032:analysis; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D032086:Evodia / Q000737:chemistry*; D005260:Female; D005638:Fruit / Q000737:chemistry; D006358:Hot Temperature; D026121:Indole Alkaloids / Q000032:analysis; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D017288:Pain Threshold / Q000187:drug effects*; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry; D011799:Quinazolines / Q000032:analysis; D013678:Technology, Pharmaceutical / Q000379:methods; D052999:Quinazolinones