Allometric scaling of marbofloxacin, moxifloxacin, danofloxacin and difloxacin pharmacokinetics: a retrospective analysis.
The purpose of this study was to examine the allometric analyses of marbofloxacin, moxifloxacin, danofloxacin and difloxacin using pharmacokinetic data from the literature. The parameters of interest (half-life, clearance and volume of distribution) were correlated across species as a function of body weight using an allometric approach (Y = aWb). Results of the allometric analysis indicated similarity between clearance and volume of distribution as they relate to body weight for all drugs. The elimination half-life was independent of body mass for all fluoroquinolones except moxifloxacin. Results of the analysis suggest that allometric scaling can be used as a tool for predicting pharmacokinetic parameters for fluoroquinolones.
Cox
S K
SK
Department of Comparative Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA. scox6@utk.edu
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001372:Aza Compounds / Q000493:pharmacokinetics; D002939:Ciprofloxacin / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D024841:Fluoroquinolones / Q000493:pharmacokinetics*; D006801:Humans; D000077266:Moxifloxacin; D011804:Quinolines / Q000493:pharmacokinetics; D015363:Quinolones / Q000493:pharmacokinetics; D012189:Retrospective Studies; D013045:Species Specificity