title: Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics.
abstract: The Center for Eukaryotic Structural Genomics (CESG) produces and solves the structures of proteins from eukaryotes. We have developed and operate a pipeline to both solve structures and to test new methodologies. Both NMR and X-ray crystallography methods are used for structure solution. CESG chooses targets based on sequence dissimilarity to known structures, medical relevance, and nominations from members of the scientific community. Many times proteins qualify in more than one of these categories. Here we review some of the structures that have connections to human health and disease.
authors.affiliation: Center for Eukaryotic Structural Genomics, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Phillips@biochem.wisc.edu
authors.forename: George N
authors.initials: GN
authors.lastname: Phillips
authors.forename: Brian G
authors.initials: BG
authors.lastname: Fox
authors.forename: John L
authors.initials: JL
authors.lastname: Markley
authors.forename: Brian F
authors.initials: BF
authors.lastname: Volkman
authors.forename: Euiyoung
authors.initials: E
authors.lastname: Bae
authors.forename: Eduard
authors.initials: E
authors.lastname: Bitto
authors.forename: Craig A
authors.initials: CA
authors.lastname: Bingman
authors.forename: Ronnie O
authors.initials: RO
authors.lastname: Frederick
authors.forename: Jason G
authors.initials: JG
authors.lastname: McCoy
authors.forename: Betsy L
authors.initials: BL
authors.lastname: Lytle
authors.forename: Brad S
authors.initials: BS
authors.lastname: Pierce
authors.forename: Jikui
authors.initials: J
authors.lastname: Song
authors.forename: Simon N
authors.initials: SN
authors.lastname: Twigger
mesh_terms: D018360:Crystallography, X-Ray / Q000639:trends; D023281:Genomics / Q000379:methods / Q000639:trends; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D011506:Proteins / Q000737:chemistry*