Enantiomerically enriched allylic alcohols and allylic amines via C-C bond-forming hydrogenation: asymmetric carbonyl and imine vinylation.
Hydrogenation of alkynes in the presence of carbonyl compounds and imines using cationic rhodium(I) and iridium(I) precatalysts enables the formation of allylic alcohols and allylic amines, respectively. Through the use of hydrogenation catalysts modified by chiral ligands, allylic alcohols and allylic amines may be generated in highly optically enriched forms. Hydrogenative fragment couplings of this type circumvent the use of preformed organometallic reagents and avoid the generation of stoichiometric byproducts.
Skucas
Eduardas
E
Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station, Welch Hall (A5300), Austin, Texas 78712-1167, USA.
Ngai
Ming-Yu
MY
Komanduri
Venukrishnan
V
Krische
Michael J
MJ