title: Dosimetric consequences of a translational isocenter correction based on image guidance for intensity modulated radiotherapy (IMRT) of the prostate.
abstract: Interfractional prostate motion during radiotherapy can have deleterious clinical consequences. It has become clinical practice to re-position the patient according to ultrasound or other imaging techniques. We investigated the dosimetric consequences of the linear translational position correction (isocenter correction) when a conformal IMRT technique with nine fields was used. Treatment plans of seven patients with empty and distended rectums were analyzed. The reference plans were calculated on the CT with an empty rectum. The treatment plans were transferred to a second CT with a distended rectum for an uncorrected setup of the patient referenced to bony anatomy and a corrected setup after translational position correction of the isocenter. The dosimetric consequences (with and without correction) were analyzed. For single treatment fractions, organ motion decreased the volume of the prostate encompassed by the 95% isodose (V95%) by up to -24%-p (percentage points). The mean rectum dose increased by up to 41%-p. Linear translational correction increased V95% of the prostate by up to 17%-p while the mean rectum dose was reduced by up to -23%-p compared to the uncorrected setup. Linear translational correction can improve radiation treatment accuracy for prostate cancer if geometrical changes are within certain limits.
authors.affiliation: Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, 68167 Mannheim, Germany. hansjoerg.wertz@radonk.ma.uni-heidelberg.de
authors.forename: H
authors.initials: H
authors.lastname: Wertz
authors.forename: F
authors.initials: F
authors.lastname: Lohr
authors.forename: B
authors.initials: B
authors.lastname: Dobler
authors.forename: S
authors.initials: S
authors.lastname: Mai
authors.forename: G
authors.initials: G
authors.lastname: Welzel
authors.forename: J
authors.initials: J
authors.lastname: Boda-Heggemann
authors.forename: F
authors.initials: F
authors.lastname: Wenz
mesh_terms: D016477:Artifacts; D006801:Humans; D008297:Male; D009038:Motion; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods