Lipid changes in rat brain during maturation.
Changes in lipid class distribution occurring during brain maturation in rats have been quantitatively investigated using a combination of DEAE column chromatography and quantitative thin-layer chromatography based on photodensitometry.Quantitative changes are presented for the single lipid classes in relation to brain weight, water content and total lipid variation at ages 2, 8, 16, 24, 37 and 50 days. The results indicate an accumulation of sphingolipids during brain maturation, particularly due to cerebrosides and sulfatides and a relative decrease of lecithin.
Galli
C
C
Institute of Pharmacology, University of Milan, Milan, Italy.
Cecconi
D R
DR