title: Microwave tomography for functional imaging of extremity soft tissues: feasibility assessment.
abstract: It is important to assess the viability of extremity soft tissues, as this component is often the determinant of the final outcome of fracture treatment. Microwave tomography (MWT) and sensing might be able to provide a fast and mobile assessment of such properties. MWT imaging of extremities possesses a complicated, nonlinear, high dielectric contrast inverse problem of diffraction tomography. There is a high dielectric contrast between bone and soft tissue in the extremities. A contrast between soft tissue abnormalities is less pronounced when compared with the high bone-soft tissue contrast. The goal of this study was to assess the feasibility of MWT for functional imaging of extremity soft tissues, i.e. to detect a relatively small contrast within soft tissues in closer proximity to high contrast boney areas. Both experimental studies and computer simulation were performed. Experiments were conducted using live pigs with compromised blood flow and compartment syndrome within an extremity. A whole 2D tomographic imaging cycle at 1 GHz was computer simulated and images were reconstructed using the Newton, MR-CSI and modified Born methods. Results of experimental studies demonstrate that microwave technology is sensitive to changes in the soft tissue blood content and elevated compartment pressure. It was demonstrated that MWT is feasible for functional imaging of extremity soft tissues, circulatory-related changes, blood flow and elevated compartment pressure.
authors.affiliation: Keele University, School of Medicine, ISTM, Stoke-on-Trent, ST4 7QB, UK. s.semenov@pmed.keele.ac.uk
authors.forename: Serguei
authors.initials: S
authors.lastname: Semenov
authors.forename: James
authors.initials: J
authors.lastname: Kellam
authors.forename: Peter
authors.initials: P
authors.lastname: Althausen
authors.forename: Thomas
authors.initials: T
authors.lastname: Williams
authors.forename: Aria
authors.initials: A
authors.lastname: Abubakar
authors.forename: Alexander
authors.initials: A
authors.lastname: Bulyshev
authors.forename: Yuri
authors.initials: Y
authors.lastname: Sizov
mesh_terms: D000818:Animals; D003161:Compartment Syndromes / Q000473:pathology*; D003238:Connective Tissue / Q000473:pathology*; D005121:Extremities / Q000473:pathology*; D005240:Feasibility Studies; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008872:Microwaves; D013552:Swine; D041622:Tomography, Optical / Q000379:methods*