Penetration of amphotericin B lipid formulations into pleural effusion.
The penetration of the amphotericin B (AMB) lipid formulations (liposomal AMB, AMB colloidal dispersion, and AMB lipid complex formulations) into pleural effusions in seven critically ill patients was assessed. AMB was detected in all pleural effusion samples at concentrations ranging from 0.02 to 0.43 microg/ml. The penetration ratio was 3 to 44%.
Weiler
Stefan
S
Department of Internal Medicine, Innsbruck Medical School, Anichstrasse 35, A-6020 Innsbruck, Austria.
Bellmann-Weiler
Rosa
R
Joannidis
Michael
M
Bellmann
Romuald
R
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000097:blood / Q000493:pharmacokinetics*; D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics; D016638:Critical Illness; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000097:blood / Q000493:pharmacokinetics*; D010715:Phosphatidylglycerols / Q000097:blood / Q000493:pharmacokinetics*; D010996:Pleural Effusion / Q000378:metabolism*