Biological and clinical relevance of anti-prothrombin antibodies.
Anti-prothrombin (anti-PT) antibodies are recently identified antibodies directed toward a phospholipid-binding protein (prothrombin), which deserve attention for the reported clinical and pathogenic relevance in antiphospholipid syndrome and systemic lupus erythematosus (SLE). We have recently carried out a longitudinal study on the predictive value of anti-PT antibodies in SLE showing that they have a higher diagnostic accuracy for thrombosis than anti-beta(2)-GPI and anticardiolipin antibodies, and, along with LAC activity, are the best predictors of thromboembolic events in SLE patients.
Ghirardello
Anna
A
Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy.
Bizzaro
Nicola
N
Zampieri
Sandra
S
Iaccarino
Luca
L
Bassi
Nicola
N
Tozzoli
Renato
R
Ruffatti
Amelia
A
Villalta
Danilo
D
Tonutti
Elio
E
Doria
Andrea
A
D000906:Antibodies / Q000097:blood* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D011516:Prothrombin / Q000276:immunology*