title: Saphenous vein graft conduits for insertion of hepatic arterial infusion pumps in patients with abnormal hepatic arterial anatomy.
abstract: OBJECTIVE
  Hepatic arterial infusion (HAI) chemotherapy offers improved hepatic control for liver metastases from colon cancer. Optimal catheter insertion requires an adequate gastroduodenal artery (GDA). Limited data exists on using saphenous vein grafts (SVG) as conduits when native vasculature is inadequate.
  
  
  METHODS
  All HAI pump insertions from 7/99 to 7/03 requiring SVG conduits (N = 10) were analyzed for arterial anatomy, operative conduct, and outcome.
  
  
  RESULTS
  From 1988 through 2005, 124 HAI pumps were placed of which 10 received SVG conduits to optimize placement. Mean operative time was 251 +/- 50 min and mean blood loss was 230 +/- 30 cm(3). All were placed with palliative intent. Three patients (30%) had type 1 anatomy with inadequate GDA. Five (50%) had type 3 anatomy with replaced right hepatic artery, one (10%) had a small GDA originating off the right hepatic artery, and one patient (10%) had a trifurcation. Two (20%) pump-related complications were identified, and only one (10%) was related to vasculature (catheter thrombosis as a result of hepatic arterial stenosis distal to the SVG insertion site).
  
  
  CONCLUSIONS
  Complication rates related to SVG conduits for hepatic arterial infusion pump placement are low. Saphenous vein grafts are acceptable conduits for patients with abnormal hepatic arterial anatomy.
authors.affiliation: Department of Surgery, Emory University, Atlanta, Georgia 30322, USA.
authors.forename: Maksym
authors.initials: M
authors.lastname: Yezhelyev
authors.forename: Michael
authors.initials: M
authors.lastname: Osgood
authors.forename: Vasili
authors.initials: V
authors.lastname: Egnatashvili
authors.forename: Alan
authors.initials: A
authors.lastname: Lumsden
authors.forename: Charles A
authors.initials: CA
authors.lastname: Staley
authors.forename: David A
authors.initials: DA
authors.lastname: Kooby
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage*; D006499:Hepatic Artery / Q000002:abnormalities*; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D012501:Saphenous Vein / Q000637:transplantation*