Spectrum of Wegener granulomatosis in a Mexican population.
Wegener granulomatosis (WG) is a disease considered infrequent among non-Caucasians. Few data exist on its characteristics in Latin America, except for isolated case reports and a paper on clinical features from a Chilean group. In this article we present the clinical characteristics of our cohort plus a preliminary evaluation of the risk factors for death. In comparison to large series from countries with a high WG prevalence, we observed similar age and gender distribution, disease category (localized or generalized), PR3-ANCA positivity, remission, relapse frequency, mortality, and death causes. These last ones are equally distributed, but infections account for an important proportion. Factors related with mortality were mainly those associated with side effects of treatment. We are currently expanding the data on this item as in other series, death is mainly related to the disease itself. The pending agenda includes knowing the prevalence and incidence of WG in Mexico, as well as other characteristics, such as genetic factors, that may influence its behavior in our country.
Flores-Suárez
Luis Felipe
LF
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Vasco de Quiroga 15, Col. Sección XVI, Tlalpan, Mexico City, Mexico. felipe98@prodigy.net.mx
Villa
Antonio R
AR
D005260:Female; D005500:Follow-Up Studies; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000453:epidemiology* / Q000473:pathology*; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged