title: Mesial temporal sclerosis after status epilepticus due to milk alkali syndrome.
abstract: Seizures induced by hypercalcemia are rare. A few case reports of seizures associated with hypercalcemia have been published, but none due to the milk alkali syndrome. This is the first report regarding seizures associated with calcium carbonate overuse. The two patients described in this article, who had no risk factors for developing epilepsy, suffered from status epilepticus probably induced by hypercalcemia. Subsequently, they both developed complex partial seizures, and were later found to have mesial temporal sclerosis on MRI. There are no reports linking hypercalcemia to mesial temporal sclerosis. While this may be a coincidence, there is reason to suspect that the development of persistent epilepsy, possibly due to mesial temporal sclerosis, was caused by prolonged seizures induced by hypercalcemia.
authors.affiliation: Dartmouth Hitchcock Medical Center, Section of Neurology, Lebanon, NH, USA. eric.dinnerstein@hitchcock.org
authors.forename: Eric
authors.initials: E
authors.lastname: Dinnerstein
authors.forename: Brenna C
authors.initials: BC
authors.lastname: McDonald
authors.forename: Howard B
authors.initials: HB
authors.lastname: Cleavinger
authors.forename: Vijay M
authors.initials: VM
authors.lastname: Thadani
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Jobst
mesh_terms: D000328:Adult; D004569:Electroencephalography; D020195:Epilepsy, Reflex / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012598:Sclerosis / Q000473:pathology; D013226:Status Epilepticus / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology