title: [Expression and significance of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma.
  
  
  METHODS
  The expression levels of TGF-beta1 and HSP70 in 53 specimens of human laryngeal squamous cell carcinoma and 48 specimens of para-carcinoma were detected by immuno- histochemistry and computer assisted image analysis.
  
  
  RESULTS
  The expression of TGF-beta1 was decreased in carcinoma tissues compared with para-carcinoma tissues ( P < 0.05), while the expression of HSP70 was increased ( P < 0.05). Both the expression of TGF-beta1 and HSP70 were significantly correlated with the differentiation of laryngeal squamous cell carcinoma (P < 0.01 or P < 0.05). However, there was a negative correlation between TGF-beta1 and HSP70 (r = -0.87, P < 0.01).
  
  
  CONCLUSIONS
  TGF-beta1 and HSP70 play an important role in malignant behaviors of human laryngeal carcinoma.
authors.affiliation: Department of Otolaryngology, First Affiliated Hospital of Chinese General Hospital of PLA, Beijing 100037, China. qits-002@163.com
authors.forename: Shuzhi
authors.initials: S
authors.lastname: Yang
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Dagen
authors.initials: D
authors.lastname: Liu
authors.forename: Erzhong
authors.initials: E
authors.lastname: Fan
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*