title: Bone mineral density in Iranian adolescents and young adults with beta-thalassemia major.
abstract: The authors investigated the prevalence of low bone mass in patients from Tehran, Iran, with beta-thalassemia major (n = 203), aged 10-20 years, and the potential risk factors for osteoporosis in this patient population. Prevalence of osteoporosis was 50.7% in lumbar spine, 10.8% in femur, and 7.9% in both regions with no significant difference between the two genders. The following factors were associated with low BMD: height for age and weight for age below 3rd percentile, delayed puberty or hypogonadism, age when Desferal (for iron chelation) was started, duration of Desferal therapy, and serum zinc. Low serum copper and 25(OH)D were not associated with low BMD.
authors.affiliation: Endocrinology and Metabolism Research Center-Tehran University of Medical Sciences and Health Services, Tehran, Iran.
authors.forename: A A
authors.initials: AA
authors.lastname: Shamshirsaz
authors.forename: M R
authors.initials: MR
authors.lastname: Bekheirnia
authors.forename: M
authors.initials: M
authors.lastname: Kamgar
authors.forename: Z
authors.initials: Z
authors.lastname: Pakbaz
authors.forename: S M
authors.initials: SM
authors.lastname: Tabatabaie
authors.forename: N
authors.initials: N
authors.lastname: Bouzari
authors.forename: N
authors.initials: N
authors.lastname: Pourzahedgilani
authors.forename: A
authors.initials: A
authors.lastname: Azarkeivan
authors.forename: S R
authors.initials: SR
authors.lastname: Hashemi
authors.forename: F
authors.initials: F
authors.lastname: Moosavi
authors.forename: M
authors.initials: M
authors.lastname: Alebouyeh
authors.forename: P
authors.initials: P
authors.lastname: Vosough
authors.forename: M
authors.initials: M
authors.lastname: Kimiagar
authors.forename: A A
authors.initials: AA
authors.lastname: Shamshirsaz
authors.forename: M
authors.initials: M
authors.lastname: Moradi
authors.forename: M R
authors.initials: MR
authors.lastname: Habibzadeh
authors.forename: N
authors.initials: N
authors.lastname: Nobakhthaghighi
authors.forename: B
authors.initials: B
authors.lastname: Larijani
mesh_terms: D000293:Adolescent; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D015995:Prevalence; D017086:beta-Thalassemia / Q000150:complications* / Q000503:physiopathology