title: Lupus anticoagulant activity as a thrombosis risk factor in lung adenocarcinoma patients.
abstract: There is a high incidence of thrombosis in cancer patients. Retrospective studies indicate that lupus anticoagulant (LA) antibodies can be a thrombosis risk factor in cancer. In 77 patients with different forms of cancer LA and thrombosis incidence were retrospectively evaluated. In a prospective study, with 42 lung adenocarcinoma patients, we measured plasma LA, fibrinogen, factor VIII (FVIII), and thrombosis incidence. A high frequency of LA and thrombosis were observed in both studies. In isolation LA, increased levels of FVIII and fibrinogen could not be considered good markers for the development of thrombosis.
authors.affiliation: Clinical Pathology, Instituto Nacional do Câncer, Rio de Janeiro, Brazil. edemeisrio@yahoo.com
authors.forename: Ernesto
authors.initials: E
authors.lastname: De Meis
authors.forename: Vera R
authors.initials: VR
authors.lastname: Pinheiro
authors.forename: Maria Aparecida L
authors.initials: MA
authors.lastname: Loures
authors.forename: Maria Mercedes
authors.initials: MM
authors.lastname: Kotouc
authors.forename: Mauro M
authors.initials: MM
authors.lastname: Zamboni
authors.forename: Maria Tereza S
authors.initials: MT
authors.lastname: Guedes
authors.forename: Ailce S
authors.initials: AS
authors.lastname: Barros
authors.forename: Ilda Akemi M
authors.initials: IA
authors.lastname: Castilho
authors.forename: Roger A
authors.initials: RA
authors.lastname: Levy
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology*; D016682:Lupus Coagulation Inhibitor / Q000378:metabolism*; D012307:Risk Factors; D013927:Thrombosis / Q000378:metabolism* / Q000473:pathology*