title: Is central obesity a good predictor of carotid atherosclerosis in Japanese type 2 diabetes with metabolic syndrome?
abstract: Metabolic syndrome has been revealed to be a major risk factor for cardiovascular disease (CVD) and early mortality in non-diabetic and diabetic patients. In 2005, the International Diabetes Federation (IDF) and the Examination Committee of Criteria for Diagnosis of Metabolic Syndrome in Japan published new definitions of metabolic syndrome in which central obesity was an indispensable factor. However, the significance of this new definition to CVD in type 2 diabetes has not yet been clarified. A cross-sectional study was conducted with 294 Japanese type 2 diabetic patients without known cardiovascular disease to evaluate the association between metabolic syndrome defined by this new definition and carotid atherosclerosis, and the significance of central obesity for the prediction of the development of carotid atherosclerosis. In a multivariate regression analysis, metabolic syndrome but not central obesity was significantly associated with carotid intima-media thickness (IMT) independent of known cardiovascular risk factors (p<0.05). In addition, whereas carotid IMT was significantly increased according to the increase in the number of components of metabolic syndrome, it was not significantly different between the groups with the same number of components of metabolic syndrome with or without central obesity. These findings suggest that the prediction of the development of carotid atherosclerosis in Japanese type 2 diabetic patients could be improved by the assessment of aggregation of components of metabolic syndrome rather than with or without metabolic syndrome by this new definition.
authors.affiliation: Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Yasuda
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Noritaka
authors.initials: N
authors.lastname: Fujiki
authors.forename: Fumie
authors.initials: F
authors.lastname: Sakamoto
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tsuji
authors.forename: Noriko
authors.initials: N
authors.lastname: Fujisawa
authors.forename: Masato
authors.initials: M
authors.lastname: Kimura
authors.forename: Rieko
authors.initials: R
authors.lastname: Ishibashi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Takao
authors.initials: T
authors.lastname: Watarai
authors.forename: Eiichi
authors.initials: E
authors.lastname: Imano
mesh_terms: D000368:Aged; D002339:Carotid Arteries / Q000473:pathology; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis*; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D017539:Tunica Intima / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D014463:Ultrasonography; D049629:Waist-Hip Ratio