title: Inactivation of Penicillins G and K by Liver and Kidney.
abstract: The inactivation of penicillin K is more rapid in the renal-ligated rabbit than in the renal-ligated, eviscerate preparation. Inactivation of penicillin K occurs in the presence of surviving liver and kidney slices. Small amounts of penicillin G were inactivated by liver slices; larger amounts disappeared in the presence of kidney slices. The inactivation of penicillin K in the presence of rabbit liver and kidney slices is demonstrable anaerobically as well as aerobically.
authors.forename: J
authors.initials: J
authors.lastname: Tepperman
authors.forename: N
authors.initials: N
authors.lastname: Rakieten
authors.forename: G
authors.initials: G
authors.lastname: Valley
authors.forename: E W
authors.initials: EW
authors.lastname: Lyon
mesh_terms: D000818:Animals; D007668:Kidney; D008099:Liver; D010400:Penicillin G; D010406:Penicillins / Q000378:metabolism*; D011817:Rabbits