title: Evaluation of current methods for the measurement of serum anti double-stranded DNA antibodies.
abstract: Autoantibodies to double-stranded DNA (dsDNA) are, by definition, serological markers of systemic lupus erythematosus. However, the clinical value of anti-dsDNA antibodies largely depends on the assay principle and analytical variables of the methods used to quantitate and immunologically characterize them. In the present article, an overview of current methods for anti-dsDNA antibody detection is presented, together with a look at the future trends in technologies newly employed in this field.
authors.affiliation: Division of Rheumatology, University of Padova, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Ghirardello
authors.forename: Danilo
authors.initials: D
authors.lastname: Villalta
authors.forename: Gabriella
authors.initials: G
authors.lastname: Morozzi
authors.forename: Antonella
authors.initials: A
authors.lastname: Afeltra
authors.forename: Mauro
authors.initials: M
authors.lastname: Galeazzi
authors.forename: Roberto
authors.initials: R
authors.lastname: Gerli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mathieu
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Meroni
authors.forename: Paola
authors.initials: P
authors.lastname: Migliorini
authors.forename: Antonella
authors.initials: A
authors.lastname: Radice
authors.forename: Valeria
authors.initials: V
authors.lastname: Riccieri
authors.forename: Amelia
authors.initials: A
authors.lastname: Ruffatti
authors.forename: Gian Domenico
authors.initials: GD
authors.lastname: Sebastiani
authors.forename: Angela
authors.initials: A
authors.lastname: Tincani
authors.forename: Andrea
authors.initials: A
authors.lastname: Doria
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood* / Q000276:immunology; D004247:DNA / Q000276:immunology; D006801:Humans; D007118:Immunoassay / Q000145:classification / Q000379:methods*; D046228:Microarray Analysis / Q000379:methods*; D012680:Sensitivity and Specificity