SLAM-associated protein solves a mystery of autoimmunity.
SLAM-associated protein (SAP) is essential for viral protection, lifelong immune memory (vaccination), and lifelong autoantibody production. We discuss how SAP is a key player in the development of autoimmune disease.
Sawada
Shigemasa
S
Department of Rheumatology and Hematology, Nihon University Nerima Hikarigaoka Hospital, 2-11-1 Hikarigaoka, Nerima-ku, Tokyo 197-0072, Japan. sswd98@med.nihon-u.ac.jp
Takei
Masami
M
Ishiwata
Tetsuyosi
T
Shiraiwa
Hidetaka
H
Inomata
Hirotake
H
Nozaki
Takamasa
T
D000818:Animals; D017209:Apoptosis; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology; D015551:Autoimmunity / Q000276:immunology*; D003001:Cloning, Molecular; D005922:Glomerulonephritis, IGA / Q000235:genetics / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000276:immunology*; D008214:Lymphocytes / Q000378:metabolism; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology