title: Prenatal ultrasound detection of talipes equinovarus in a non-selected population of 49 314 deliveries in Norway.
abstract: OBJECTIVE
  To evaluate prenatal ultrasound detection of talipes equinovarus (TEV) in a large non-selected population and to study trends in detection rates over time, as well as the prevalence and outcome of isolated TEV and TEV with associated anomalies.
  
  
  METHODS
  All cases of pre- or postnatally diagnosed TEV between 1987 and 2004 within a non-selected population of 49 314 deliveries were investigated. The study period was divided into three 6-year periods to shed light on changes in detection rates and other aspects of the anomaly over time.
  
  
  RESULTS
  A total of 113 cases of TEV were registered during the 18-year period, of which 49% had isolated TEV and 51% had associated anomalies. During the three 6-year periods, there was a significant improvement (P = 0.006) in the overall detection of TEV from 43% to 67% and 77%, respectively. The detection rate for isolated TEV increased over time. Isolated bilateral TEV cases were detected more than twice as often as isolated unilateral TEV. The three largest groups of associated anomalies were syndromes/sequences (26%), chromosome aberrations (26%), and musculoskeletal disorders (24%). Pregnancies were terminated in 23% of the cases, all with severe additional anomalies. Treatment of TEV included surgery in 86% of the cases.
  
  
  CONCLUSIONS
  The overall detection rate of TEV improved significantly over time. Prenatal detection was higher when TEV was bilateral and when other associated anomalies were present. Parents should be informed that, in suspected isolated TEV, associated anomalies might remain undetected prenatally.
authors.affiliation: National Center for Fetal Medicine, Women and Children's Centre, St. Olavs University Hospital and Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway. kristin.offerdal@ntnu.no
authors.forename: K
authors.initials: K
authors.lastname: Offerdal
authors.forename: N
authors.initials: N
authors.lastname: Jebens
authors.forename: H G K
authors.initials: HG
authors.lastname: Blaas
authors.forename: S H
authors.initials: SH
authors.lastname: Eik-Nes
mesh_terms: D003025:Clubfoot / Q000000981:diagnostic imaging* / Q000453:epidemiology; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009664:Norway / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D015995:Prevalence; D016216:Ultrasonography, Prenatal / Q000379:methods