[Expression of DcR3 protein and its significance in laryngeal carcinoma].
OBJECTIVE
To investigate the expression of DcR3 in laryngeal carcinoma and analyze the relation between DcR3 and clinical factors.


METHODS
The expression of DcR3 protein in 41 laryngeal carcinoma tissues and 41 para-carcinoma tissues (to cutting margin > 0.5 cm) were measured by Flow Cytometer(Epics-XL II), 15 normal laryngeal mucosa tissues were served as controls.


RESULTS
(1) The quantitative and qualitative expression of DcR3 protein in laryngeal carcinoma tissues was obviously higher than those in para-carcinoma and normal laryngeal mucosa tissues, respectively (P < 0.05). There was no significant difference for the DcR3 protein expression between para-carcinoma and normal laryngeal mucosa tissues. (2) In laryngeal carcinoma, the expression of DcR3 protein was not significantly related to clinical classification, tumor size, smoking history, patients' age and sex but related to metastasis, pathological grade and clinical stage.


CONCLUSIONS
The high level of DcR3 expression may contribute to the carcinogenesis and development of laryngeal carcinoma. So it can be an important index for judging the differentiation, infiltration, metastasis and staging of laryngeal carcinoma.
Li
Lianhe
L
Department of Otolaryngology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China. llh186@265.com
Hu
Junlan
J
Zhao
Ruili
R
Yue
Zhuoli
Z
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D053323:Receptors, Tumor Necrosis Factor, Member 6b / Q000378:metabolism*