A comparison of propofol and thiopentone use in electroconvulsive therapy: cognitive and efficacy effects.
OBJECTIVE
The purpose of this study was to compare thiopentone and propofol administration for electroconvulsive therapy (ECT) in terms of associated efficacy and cognitive side effects in the immediate and medium term.


METHODS
Participants comprised 30 depressed patients who were administered either propofol or thiopentone as an anesthetic agent for ECT. Clinical rating scales and a battery of neuropsychological tests were administered at baseline, after 6 treatments, 1 to 3 days after treatment end point, and at 1-month follow-up.


RESULTS
Thiopentone administration was associated with advantages in efficacy and cognitive side effects compared with propofol administration.


CONCLUSIONS
This study reports some serendipitous findings regarding the comparative effects of the anesthetic agents, propofol and thiopentone. Although limited by small sample size, results suggest that thiopentone has advantages for use as an anesthetic agent with ECT compared with propofol. It also highlights the need for further investigation of the impact of anesthetic agents on the cognitive side effects and efficacy of ECT.
Ingram
Anna
A
Department of Psychology, The University of Melbourne, Australia. Ingram@healthscope.com.au
Schweitzer
Isaac
I
Ng
Chee H
CH
Saling
Michael M
MM
Savage
Greg
G
D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D003863:Depression / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D018401:Sample Size; D013874:Thiopental / Q000494:pharmacology*; D016896:Treatment Outcome