A physical analogy of the genetic toggle switch.
We show that there is a physical analogy between a stochastic model of a genetic toggle switch system and a thermostated particle moving in a potential field, derived from the probability distribution of the toggle switch. This result suggests that one can actually simulate the dynamics of a more complex gene network by considering an ensemble of thermostated particles moving in a potential field, derived from the stationary distribution of the chemical stochastic model describing the gene network.
Andrecut
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Institute for Biocomplexity and Informatics, University of Calgary, Calgary, Alberta, Canada. mandrecu@ucalgary.ca
Kauffman
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D000465:Algorithms; D003198:Computer Simulation; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D008957:Models, Genetic; D009010:Monte Carlo Method; D013269:Stochastic Processes