MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets.
MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.
van Rooij
Eva
E
Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9148, USA.
Olson
Eric N
EN
D000818:Animals; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D006331:Heart Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009200:Myocardial Contraction; D010641:Phenotype