[Factors influencing the survival of patients with skull base chordoma].
OBJECTIVE
To investigate the factors influencing the survival of patients with skull base chordoma.


METHODS
The clinical data of 79 patients with skull base chordoma, with a male/female ratio of 1.3:1, who received operations in Tiantan Hospital between May 1993 and June 2005 were selected. Thirteen factors, including gender, age, main symptoms, positive signs, bulk of the tumor, having received operation or radiotherapy before admission, grouping and staging of the tumor's location, and texture, adherence, pathological and resection grouping of the lesion, underwent Kaplan-Meier single factor analysis, Cox regression, and t-test.


RESULTS
Kaplan-Meier single factor analysis displayed that having received operation or radiotherapy before admission, adherence, pathological and resection groupings of the lesion were the risk factors of the patients' life span (all P < 0.01). Cox multiple factor analysis showed that the all of the above factors except adherence grouping of the lesion had statistical significance on the patients' life span (all P < 0.01).


CONCLUSIONS
Having received operation or radiotherapy before admission, adherence, pathological and resection groupings of the lesion influence the prognosis of skull base chordoma.
Zhang
Jun-Ting
JT
Department of Neurosurgery, Beijing Tiantan Hospital, Beijing 100050, China.
Wang
Liang
L
Wu
Zhen
Z
Jia
Gui-Jun
GJ
Zhang
Li-Wei
LW
D000328:Adult; D002817:Chordoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D011379:Prognosis; D016016:Proportional Hazards Models; D011878:Radiotherapy / Q000379:methods / Q000706:statistics & numerical data; D012307:Risk Factors; D019292:Skull Base Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D013514:Surgical Procedures, Operative / Q000379:methods / Q000706:statistics & numerical data; D015996:Survival Rate