Possible Mode of Antidepressive Action of Imipramine.
Imipramine augmented and prolonged methamphetamine-induced increases in the rate of responding of rats working for "rewarding" hypothalamic and midbrain stimulation. In contrast, chlorpromazine antagonized the effects of methamphetamine on self-stimulation. These opposite psychopharmacological effects are consistent with the different clinical effects of these drugs and suggest a mechanism for the antidepressive action of imipramine.
Stein
L
L
Seifter
J
J