Recalling P446. P4501A1 (CYP1A1) opting for clinical application.
This review goes back to spectral studies [see Hildebrandt et al., 1968]. The findings of apparent absolute spectra of two interconvertible forms of microsomal mixed function oxidases are looked back on to recall whether their impact sustained scrutiny or are rather remembered as of sentimental value only. The second part summarizes studies on the clinical relevance of CYP1A1 with special reference to our investigations. The impact of genetic variability of CYP1A1 on cancer susceptibility, differential effects of polyphenols and hyperforin on toxification and detoxification pathways of benzo[a]pyrene, and differential metabolite patterns of 17 beta-estradiol, estrone, and eicosapentaenoic acid are presented.
Hildebrandt
Alfred G
AG
Drachenfelsstr., Bonn, Germany. abhildebrandt@aol.com
Schwarz
Dieter
D
Krusekopf
Solveigh
S
Kleeberg
Ullrich
U
Roots
Ivar
I
D000818:Animals; D019363:Cytochrome P-450 CYP1A1 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009747:Nutritional Physiological Phenomena; D010601:Pharmacology, Clinical; D013056:Spectrophotometry, Ultraviolet; D009626:Terminology as Topic; D014116:Toxicology