Assessment of population structure and major circulating phylogeographical clades of Mycobacterium tuberculosis complex in Bangladesh suggests a high prevalence of a specific subclade of ancient M. tuberculosis genotypes.
Spoligotyping was performed to study the population structure of Mycobacterium tuberculosis complex strains (n = 224) from Bangladesh. Strains were split into principal genetic group 1 (PGG 1 [75.0%]) and PGG 2 and 3 (25%). Forty-nine strains with a new spoligotype signature and considered as south or southeast Asian-linked emerging clones were designated as "Matlab type."
Rahim
Zeaur
Z
International Centre for Diarrhoeal Disease Research, Bangladesh, Center for Health and Population Research, Dhaka, Bangladesh. zeaur@icddrb.org
Zaman
Khadiza
K
van der Zanden
Adri G M
AG
Möllers
Marius J
MJ
van Soolingen
Dick
D
Raqib
Rubhana
R
Zaman
Khalequ
K
Begum
Vikarunessa
V
Rigouts
Leen
L
Portaels
Françoise
F
Rastogi
Nalin
N
Sola
Christophe
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001459:Bangladesh; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics