title: A dose-effect analysis of children's exposure to dental amalgam and neuropsychological function: the New England Children's Amalgam Trial.
abstract: BACKGROUND
  The New England Children's Amalgam Trial (NECAT) was a five-year randomized trial of 534 6- to 10-year-old children that compared the neuropsychological outcomes of those whose caries were restored using dental amalgam with the outcomes of those those whose caries were restored using mercury-free resin-based composite. The primary intention-to-treat analyses did not reveal significant differences between the treatment groups on the primary or secondary outcomes of the administered psychological tests: Full-Scale IQ score on the Wechsler Intelligence Scale for Children-Third Edition, General Memory Index of the Wide Range Assessment of Memory and Learning, and Visual-Motor Composite of the Wide Range Assessment of Visual Motor Abilities.
  
  
  METHODS
  To determine whether treatment group assignment, a dichotomous measure of exposure, was sufficiently sensitive to detect associations between mercury exposure and these outcomes, the authors conducted analyses to evaluate the associations between the primary and secondary outcomes and two continuously distributed indexes of potential exposure, surface-years of amalgam and urinary mercury excretion.
  
  
  RESULTS
  Neither index of mercury exposure was significantly associated with any of the three outcomes.
  
  
  CONCLUSIONS
  The authors found no evidence that exposure to mercury from dental amalgam was associated with any adverse neuropsychological effects over the five-year period after placement of amalgam restorations.
  
  
  CONCLUSIONS
  Analyses of the outcomes of the NECAT study indicate that use of dental amalgam was not associated with an increase in children's risk of experiencing neuropsychological dysfunction.
authors.affiliation: Children's Hospital, Boston, MA, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Bellinger
authors.forename: Felicia
authors.initials: F
authors.lastname: Trachtenberg
authors.forename: David
authors.initials: D
authors.lastname: Daniel
authors.forename: Annie
authors.initials: A
authors.lastname: Zhang
authors.forename: Mary A
authors.initials: MA
authors.lastname: Tavares
authors.forename: Sonja
authors.initials: S
authors.lastname: McKinlay
mesh_terms: D000704:Analysis of Variance; D001900:Boston; D002648:Child; D003188:Composite Resins; D003723:Dental Amalgam / Q000009:adverse effects*; D003793:Dental Restoration, Permanent / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007360:Intelligence / Q000187:drug effects*; D007361:Intelligence Tests; D008281:Maine; D008297:Male; D008404:Massachusetts; D008568:Memory / Q000187:drug effects*; D008628:Mercury / Q000009:adverse effects / Q000652:urine; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects*