title: Phase II PETHEMA trial of alternating bortezomib and dexamethasone as induction regimen before autologous stem-cell transplantation in younger patients with multiple myeloma: efficacy and clinical implications of tumor response kinetics.
abstract: OBJECTIVE
  This is the first study in which bortezomib and dexamethasone were administered on an alternating basis as up-front therapy in multiple myeloma (MM). We investigated the efficacy and kinetics of response to each drug and safety.
  
  
  METHODS
  Patients with newly diagnosed MM who were less than 66 years old were treated with bortezomib at 1.3 mg/m2 on days 1, 4, 8, and 11 (cycles 1, 3, and 5) and dexamethasone 40 mg orally on days 1 through 4, 9 to 12, and 17 to 20 (cycles 2, 4, and 6), followed by autologous stem-cell transplantation (ASCT). Responses were evaluated by modified European Bone Marrow Transplantation criteria. Random effects models were used to analyze the tumor response kinetics.
  
  
  RESULTS
  Forty patients were enrolled. Partial response (PR) or greater was 65% (12.5% complete response [CR], 10% very good PR [VGPR], and 42.5% PR) plus 17.5% minor response. Time to response was rapid, with 82% serum M-protein reduction achieved within the first two cycles. The M-protein decrease was similar with dexamethasone and with bortezomib (P = .48). Chromosome 13 deletion, t(4;14), and t(14;16) did not have a negative impact on response. Toxicity was low, with no grade 3 to 4 peripheral neuropathy and no grade 2 to 4 thrombocytopenia. The response rate after ASCT was 88%, with 33% CR (negative immunofixation) plus 22% VGPR.
  
  
  CONCLUSIONS
  Bortezomib alternating with dexamethasone is a highly effective induction regimen with low toxicity. The kinetic study has shown a high degree of heterogeneity in response and rapid effect from both agents, supporting the use of a short induction regimen before ASCT in MM.
authors.affiliation: Hospital Clinic Barcelona, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Rosiñol
authors.forename: Albert
authors.initials: A
authors.lastname: Oriol
authors.forename: Maria Victoria
authors.initials: MV
authors.lastname: Mateos
authors.forename: Anna
authors.initials: A
authors.lastname: Sureda
authors.forename: Pedro
authors.initials: P
authors.lastname: García-Sánchez
authors.forename: Norma
authors.initials: N
authors.lastname: Gutiérrez
authors.forename: Adrián
authors.initials: A
authors.lastname: Alegre
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Lahuerta
authors.forename: Javier
authors.initials: J
authors.lastname: de la Rubia
authors.forename: Carlos
authors.initials: C
authors.lastname: Herrero
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Liu
authors.forename: Helgi
authors.initials: H
authors.lastname: Van de Velde
authors.forename: Jesús
authors.initials: J
authors.lastname: San Miguel
authors.forename: Joan
authors.initials: J
authors.lastname: Bladé
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D003907:Dexamethasone / Q000008:administration & dosage; D004334:Drug Administration Schedule; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000628:therapy*; D011719:Pyrazines / Q000008:administration & dosage; D012074:Remission Induction; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous