title: A new family of histamine H3 receptor antagonists based on a natural product: discovery, SAR, and properties of the series.
authors.affiliation: Abbott Laboratories, GPRD Neuroscience Research, R4MN, AP9A-216, Abbott Park, IL 60064-6123, USA. marlon.d.cowart@abbott.com
authors.forename: M
authors.initials: M
authors.lastname: Cowart
authors.forename: M
authors.initials: M
authors.lastname: Sun
authors.forename: C
authors.initials: C
authors.lastname: Zhao
authors.forename: D G
authors.initials: DG
authors.lastname: Witte
authors.forename: T R
authors.initials: TR
authors.lastname: Miller
authors.forename: K M
authors.initials: KM
authors.lastname: Krueger
authors.forename: K
authors.initials: K
authors.lastname: Browman
authors.forename: G B
authors.initials: GB
authors.lastname: Fox
authors.forename: Y L
authors.initials: YL
authors.lastname: Bennani
authors.forename: T A
authors.initials: TA
authors.lastname: Esbenshade
authors.forename: A A
authors.initials: AA
authors.lastname: Hancock
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006160:Guanosine Triphosphate / Q000378:metabolism; D017442:Histamine Agonists / Q000378:metabolism; D006633:Histamine Antagonists / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008297:Male; D015394:Molecular Structure; D051381:Rats; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D013329:Structure-Activity Relationship