Isolation of a trimer of alpha-tocopherol from mammalian liver.
Evidence is presented for the formation in mammalian liver of a trimeric metabolite of alpha-tocopherol. This compound has been shown to be identical to a trimer produced by oxidation of alpha-tocopherol with alkaline K(3)Fe(CN)(6). In addition, confirmation was obtained for the occurrence in vivo of a dimeric metabolite reported previously. These compounds, together with tocopheryl-p-quinone, are postulated to arise from reactions with lipid-free radicals or peroxides in the course of the antioxidant action of vitamin E.
Draper
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HH
Division of Nutritional Biochemistry, Department of Animal Science, University of Illinois, Urbana, Illinois.
Csallany
A S
AS
Chiu
M
M