title: [Gastric stromal tumor. Case report].
abstract: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastro intestinal tract and express the c-kit proto-oncogene protein (CD-117). We report herein a case of a 58 years old male with upper abdominal pain and anaemia. Preoperative endoscopic and barium meal exams showed a submucosal tumor in the gastric fornix. Endoscopic biopsy revealed spindle-shaped cells with elongated nuclei specific of GIST. We performed a stapled resection of the gastric fornix associated with Hiss angle reconstruction. Postoperative histologic exam revealed the same spindle-shape cells characteristic of GIST with 2-5 mitosis/50HPF. Almost all of the cells showed immunoreactivity for c-kit, CD-34 and a Ki-67 labeling index of 30%. Postoperative course was non eventful and after 3 month the patient has no recurrence.
  
  
  CONCLUSIONS
  GIST are rare gastric tumors and are usually associated with bleeding and abdominal pain. The preoperative diagnosis is usually established by endoscopy with biopsy or endoscopic ultrasonography fine needle aspiration and barium meal exam. Only immunoreactivity is able to differentiate GIST from other mesenchymal tumors. Surgical resection is a safe and effective treatment. The chemotherapy with tyrosine kinases competitive inhibitors (e.g. imatinib mesylate) is also recommended.
authors.affiliation: Universitatea de Medicină 5i Farmacie Gr. T. Popa Iaşi, Facultatea de Medicină.
authors.forename: R
authors.initials: R
authors.lastname: Moldovanu
authors.forename: C
authors.initials: C
authors.lastname: Lupaşcu
authors.forename: Cătălina Maria
authors.initials: CM
authors.lastname: Moldovanu
authors.forename: G
authors.initials: G
authors.lastname: Dimofte
authors.forename: B
authors.initials: B
authors.lastname: Tuţuianu
authors.forename: E
authors.initials: E
authors.lastname: Târcoveanu
authors.forename: Felicia
authors.initials: F
authors.lastname: Crumpei
authors.forename: D
authors.initials: D
authors.lastname: Ferariu
authors.forename: Laurrette
authors.initials: L
authors.lastname: Cozma
authors.forename: A
authors.initials: A
authors.lastname: Vasilescu
authors.forename: V
authors.initials: V
authors.lastname: Filip
authors.forename: N
authors.initials: N
authors.lastname: Vlad
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D014408:Biomarkers, Tumor / Q000032:analysis; D005743:Gastrectomy / Q000379:methods; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D000090063:Proto-Oncogene Mas; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D011743:Pyrimidines / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D017792:Surgical Stapling; D016896:Treatment Outcome