title: Industrial-scale synthesis and applications of asymmetric hydrogenation catalysts.
abstract: This Account provides an overview of our activities in the area of asymmetric hydrogenation over the last 12 years. We discuss the manufacture of metal-containing precatalysts and their use in asymmetric hydrogenation processes. Many of the metal complexes have been made on a multikilogram scale for our own use and also provided to our customers. In addition, we review some of the applications that we have developed for our asymmetric hydrogenation catalysts, many of which have been operated on commercial scales. This all underlines that asymmetric hydrogenation is a mature technology that has been adopted for use in the pharmaceutical and fine-chemical industries.
authors.affiliation: Dowpharma, Chirotech Technology Limited, A Subsidiary of the Dow Chemical Company, Unit 162 Cambridge Science Park, Milton Road, Cambridge, CB4 0GH, United Kingdom.
authors.forename: Nicholas B
authors.initials: NB
authors.lastname: Johnson
authors.forename: Ian C
authors.initials: IC
authors.lastname: Lennon
authors.forename: Paul H
authors.initials: PH
authors.lastname: Moran
authors.forename: James A
authors.initials: JA
authors.lastname: Ramsden
mesh_terms: D002384:Catalysis; D002617:Chemical Industry / Q000379:methods*; D006865:Hydrogenation; D012238:Rhodium / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism