title: Fatal hepatitis C associated fibrosing cholestatic hepatitis as a complication of cyclophosphamide and corticosteroid treatment of active glomerulonephritis.
abstract: Fibrosing cholestatic hepatitis (FCH) is an aggressive and usually fatal form of viral hepatitis in immunocompromised patients. It is characterized by progressive cholestasis leading to hepatic failure, and a characteristic histopathological features including: periportal fibrosis, ballooning degeneration of hepatocytes, cholestasis, with minimal inflammation. FCH has been reported almost exclusively in heavily immunosuppressed organ transplant recipients or patients with AIDS. This case report describes a previously immunocompetent patient with previously stable chronic hepatitis C who developed fibrosing cholestatic hepatitis after receiving cyclophosphamide and corticosteroids for active glomerulonephritis.
authors.affiliation: Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Faisal
authors.initials: F
authors.lastname: Saleh
authors.forename: Hin Hin
authors.initials: HH
authors.lastname: Ko
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Davis
authors.forename: Wichian
authors.initials: W
authors.lastname: Apiratpracha
authors.forename: James J
authors.initials: JJ
authors.lastname: Powell
authors.forename: Siegfried R
authors.initials: SR
authors.lastname: Erb
authors.forename: Eric M
authors.initials: EM
authors.lastname: Yoshida
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged