Coronary artery bypass grafting ameliorates the decreased plasma adiponectin level in atherosclerotic patients.
Adiponectin functions as an anti-inflammatory and anti-atherogenic factor, and the decreased plasma adiponectin is a risk factor for coronary disease. The aim of this study was to determine the changes in plasma levels of adiponectin, a potential parameter for atherosclerosis, in patients underwent surgical revascularization. We included forty patients with atherosclerosis (age, 58 +/- 9 years; body mass index [BMI] 26.93 +/- 2.3 kg/m(2)) undergoing coronary artery bypass grafting (CABG). Control group consisted of 40 healthy volunteers, matched for age, gender and BMI (age, 56 +/- 6 years; BMI, 26.78 +/- 2.3 kg/m(2)). We measured various parameters, including high sensitive C-reactive protein (hsCRP), homeostasis model assessment-insulin resistance (HOMA-IR) indexes, and adiponectin. The baseline profile of the patients before CABG showed higher levels of serum hsCRP (13.15 +/- 2.40 mg/l vs 3.97 +/- 1.07 mg/l) and HOMA-IR (1.86 +/- 0.30 vs 1.26 +/- 0.33) and lower plasma adiponectin levels (7.02 +/- 2.01 microg/ml vs 25.46 +/- 3.9 microg/ml), compared to controls (p < 0.001 for each parameter). Plasma adiponectin level was increased one month after CABG from the baseline level to 8.67 +/- 2.05 microg/ml(p < 0.001), although the level was still lower than the control value. Thus, postoperative adiponectin level might be helpful for evaluating the progression of atherosclerosis. Moreover, CABG significantly decreased hsCRP to 7.25 +/- 1.89 mg/l and HOMA-IR to 1.59 +/- 0.33, although these levels were higher than the controls. These results suggest that CABG decreases the cardiac risk factors in atherosclerotic patients.
Eyileten
Zeynep
Z
Department of Cardiovascular Surgery, Ankara University School of Medicine, Dikimevi, Ankara, Turkey. zeynepb1965@yahoo.com
Yilmaz
Mahmut Ilker
MI
Kaya
Kaan
K
Akar
A Ruchan
AR
Kahraman
Dogan
D
Bingol
Sezin
S
Uysalel
Adnan
A
Ozyurda
Umit
U
D052242:Adiponectin / Q000097:blood*; D050197:Atherosclerosis / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D064030:S100 Calcium Binding Protein G