Long-term study on symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients.
From October 2004 through October 2006 a study was performed to evaluate the prevalence of human Metapneumovirus (hMPV) infection in adult hematopoietic stem cell transplant (HSCT) recipients. Sequential nasopharyngeal aspirates (NPA) were collected independently from respiratory symptoms and evaluated for hMPV-RNA by polymerase chain reaction (PCR) and sequence analysis. Results indicate epidemiological and molecular differences between the 2004-2005 and 2005-2006 periods and that hMPV seems not to symptomatically affect HSCT patients or cause late respiratory sequelae. In addition, data collected suggest a hospital origin of hMPV infection in most HSCT patients during the 2004-2005 period.
Debiaggi
Maurizia
M
Dipartimento Scienze Morfologiche Eidologiche e Cliniche, Sezione Microbiologia, Università di Pavia, Italy. mdeb@unipv.it
Canducci
Filippo
F
Terulla
Cristina
C
Sampaolo
Michela
M
Marinozzi
Maria Chiara
MC
Alessandrino
Paolo Emilio
PE
Colombo
Anna Amelia
AA
Caldera
Daniela
D
Bragotti
Letizia Zenone
LZ
Migliavacca
Roberta
R
Bianchi
Emanuela
E
Romero
Egidio
E
Clementi
Massimo
M
D000208:Acute Disease; D000328:Adult; D002353:Carrier State; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008137:Longitudinal Studies; D029121:Metapneumovirus / Q000235:genetics* / Q000302:isolation & purification; D009305:Nasopharynx / Q000821:virology; D018184:Paramyxoviridae Infections / Q000453:epidemiology* / Q000209:etiology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics; D012140:Respiratory Tract Diseases / Q000453:epidemiology* / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012621:Seasons; D017421:Sequence Analysis