Stem cells and debrided waste: two alternative sources of cells for transplantation of cartilage.
Implantation of autologous chondrocytes and matrix autologous chondrocytes are techniques of cartilage repair used in the young adult knee which require harvesting of healthy cartilage and which may cause iatrogenic damage to the joint. This study explores alternative sources of autologous cells. Chondrocytes obtained from autologous bone-marrow-derived cells and those from the damaged cartilage within the lesion itself are shown to be viable alternatives to harvest-derived cells. A sufficient number and quality of cells were obtained by the new techniques and may be suitable for autologous chondrocyte and matrix autologous chondrocyte implantation.
Biant
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LC
The Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, UK.
Bentley
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G
D000293:Adolescent; D000328:Adult; D002358:Cartilage, Articular / Q000293:injuries / Q000473:pathology / Q000601:surgery*; D017690:Cell Transplantation / Q000379:methods*; D019902:Chondrocytes / Q000637:transplantation*; D003646:Debridement; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000517:prevention & control / Q000601:surgery*; D007719:Knee Joint / Q000473:pathology / Q000601:surgery*; D008297:Male; D013234:Stem Cells / Q000166:cytology*; D014182:Transplantation, Autologous