Retinal detachment with macular hole following combined photodynamic therapy and intravitreal bevacizumab injection.
OBJECTIVE
To report a case of retinal detachment with a macular hole following photodynamic therapy (PDT) using verteporfin and intravitreal bevacizumab injection in the treatment of myopic choroidal neovascularization (CNV).


METHODS
A 58 -year-old woman was diagnosed with myopic CNV and treated with a combination of PDT with verteporfin and intravitreal bevacizumab injection that same day. She received the second injection of intravitreal bevacizumab four weeks after the initial treatment.


RESULTS
The patient developed a sudden decline in vision one week after the second injection; and was subsequently diagnosed with retinal detachment associated with a macular hole. She underwent standard three-port pars plana vitrectomy with internal limiting membrane peeling, fluid-air exchange and silicone oil injection. The retina was still firmly attached at the patient's final follow-up visit.


CONCLUSIONS
PDT and intravitreal bevacizumab injection used for the treatment of myopic CNV can be associated with retinal detachment with a macular hole. Patients need to be informed about this potential complication, and a higher index of suspicion may be warranted in patients who report sudden vision loss after the treatment.
Chung
Eun Jee
EJ
The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
Koh
Hyoung Jun
HJ
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D020256:Choroidal Neovascularization / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007267:Injections; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects*; D012163:Retinal Detachment / Q000209:etiology*; D012167:Retinal Perforations / Q000209:etiology*; D014822:Vitreous Body