Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics.
The Center for Eukaryotic Structural Genomics (CESG) produces and solves the structures of proteins from eukaryotes. We have developed and operate a pipeline to both solve structures and to test new methodologies. Both NMR and X-ray crystallography methods are used for structure solution. CESG chooses targets based on sequence dissimilarity to known structures, medical relevance, and nominations from members of the scientific community. Many times proteins qualify in more than one of these categories. Here we review some of the structures that have connections to human health and disease.
Phillips
George N
GN
Center for Eukaryotic Structural Genomics, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Phillips@biochem.wisc.edu
Fox
Brian G
BG
Markley
John L
JL
Volkman
Brian F
BF
Bae
Euiyoung
E
Bitto
Eduard
E
Bingman
Craig A
CA
Frederick
Ronnie O
RO
McCoy
Jason G
JG
Lytle
Betsy L
BL
Pierce
Brad S
BS
Song
Jikui
J
Twigger
Simon N
SN
D018360:Crystallography, X-Ray / Q000639:trends; D023281:Genomics / Q000379:methods / Q000639:trends; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D011506:Proteins / Q000737:chemistry*