title: 5-methyltetrahydrofolic Acid as a mediator in the formation of pyridoindoles.
abstract: Enzymes from chick and rat tissues catalyze the reaction of N-methyl tryptamine with 5-methyltetrahydrofolic acid to form 2,3,4,9-tetrahydro-2-methyl-1H-pyrido[3,4b] indole. N,N-Dimethyltryptamine was not formed. With tryptamine as substrate the product is 2,3,4,9-tetrahydro-1H-pyrido[3,4b] indole and not N-methyltryptamine. These pyridoindoles were not formed when S-adenosylmethionine was cosubstrare.
authors.forename: L R
authors.initials: LR
authors.lastname: Mandel
authors.forename: A
authors.initials: A
authors.lastname: Rosegay
authors.forename: R W
authors.initials: RW
authors.lastname: Walker
authors.forename: W J
authors.initials: WJ
authors.lastname: Vandenheuvel
authors.forename: J
authors.initials: J
authors.lastname: Rokach