Anemia and antibodies to the 19-kDa fragment of MSP1 during Plasmodium falciparum infection in Aotus monkeys.
To determine whether antibodies to the 19-kDa fragment of merozoite surface protein 1 (MSP1(19)) help to control blood-stage Plasmodium falciparum infection, we performed a rechallenge experiment of previously infected Aotus monkeys. Monkeys previously exposed to the FVO strain of P. falciparum that did or did not develop high antibody titers to MSP1(19) and malaria-naïve monkeys were challenged with erythrocytes infected with the same strain. Prepatent periods were prolonged in previously infected monkeys compared with malaria-naïve monkeys. Previously infected monkeys with preexisting anti-MSP1(19) antibodies showed low peak parasitemias that cleared spontaneously. Previously infected monkeys that had no or low levels of pre-existing anti-MSP1(19) antibodies also showed low peak parasitemias, but because of low hematocrits, all of these animals required treatment with mefloquine. All previously malaria-naïve animals were treated because of high parasitemias. The results of this study suggest that antibody to the 19-kDa carboxy-terminal fragment of MSP1 plays a role in preventing the development of anemia, an important complication often associated with malaria.
Gozalo
Alfonso S
AS
US Naval Medical Research Center Detachment, Lima, Peru. gozaloa@niaid.nih.gov
Lucas
Carmen M
CM
Qin
Jing
J
Hall
B Ted
BT
Magill
Alan J
AJ
D000740:Anemia / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology*; D000962:Antimalarials / Q000627:therapeutic use; D016645:Aotidae; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000469:parasitology; D016778:Malaria, Falciparum / Q000150:complications / Q000276:immunology* / Q000473:pathology; D015767:Mefloquine / Q000627:therapeutic use; D020066:Merozoite Surface Protein 1 / Q000008:administration & dosage / Q000276:immunology*; D008992:Monkey Diseases / Q000276:immunology / Q000469:parasitology* / Q000473:pathology; D018512:Parasitemia / Q000188:drug therapy / Q000276:immunology; D010963:Plasmodium falciparum / Q000254:growth & development / Q000276:immunology*