title: Implicit learning of sequential regularities and spatial contexts in corticobasal syndrome.
abstract: The present study investigated two forms of implicit learning in patients with corticobasal syndrome (CBS): contextual cueing and sequence learning. The former primarily implicates the medial temporal lobe system, and the latter, fronto-striatal-cerebellar circuits. Results revealed relatively preserved contextual cueing in patients with CBS. By contrast, sequence learning showed impairments, which seemed to reflect inability to execute correct responses in the presence of intact learning of the sequence. These findings provide the first characterization of implicit learning systems in CBS, and show that the two systems are differentially affected in patients with CBS.
authors.affiliation: Mayo Clinic, Rochester, MN 55905, USA. negash.selamawit@mayo.edu
authors.forename: Selam
authors.initials: S
authors.lastname: Negash
authors.forename: Bradley F
authors.initials: BF
authors.lastname: Boeve
authors.forename: Yonas E
authors.initials: YE
authors.lastname: Geda
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Smith
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Ivnik
authors.forename: Darlene V
authors.initials: DV
authors.lastname: Howard
authors.forename: James H
authors.initials: JH
authors.lastname: Howard
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001245:Association Learning / Q000502:physiology*; D001479:Basal Ganglia / Q000503:physiopathology*; D001927:Brain Diseases / Q000473:pathology* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D003463:Cues; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D011930:Reaction Time / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D014057:Tomography, X-Ray Computed / Q000379:methods