[Expression and significance of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma].
OBJECTIVE
To investigate the expression of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma.


METHODS
The expression levels of TGF-beta1 and HSP70 in 53 specimens of human laryngeal squamous cell carcinoma and 48 specimens of para-carcinoma were detected by immuno- histochemistry and computer assisted image analysis.


RESULTS
The expression of TGF-beta1 was decreased in carcinoma tissues compared with para-carcinoma tissues ( P < 0.05), while the expression of HSP70 was increased ( P < 0.05). Both the expression of TGF-beta1 and HSP70 were significantly correlated with the differentiation of laryngeal squamous cell carcinoma (P < 0.01 or P < 0.05). However, there was a negative correlation between TGF-beta1 and HSP70 (r = -0.87, P < 0.01).


CONCLUSIONS
TGF-beta1 and HSP70 play an important role in malignant behaviors of human laryngeal carcinoma.
Yang
Shuzhi
S
Department of Otolaryngology, First Affiliated Hospital of Chinese General Hospital of PLA, Beijing 100037, China. qits-002@163.com
Chen
Haiyan
H
Zhang
Wei
W
Liu
Dagen
D
Fan
Erzhong
E
Li
Ying
Y
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*