title: Surveillance of Toxoplasma gondii infection in recipients of thoracic solid organ transplants.
abstract: We evaluated the frequency of seroconversion for toxoplasmosis in seronegative recipients of thoracic solid organ transplants with seronegative or seropositive donors and the efficacy of chemoprophylaxis with pyrimethamine+sulfametopirazine. One hundred and sixty one patients seronegative for toxoplasmosis were followed-up at different intervals. Six patients out of 79 R-/D- and twelve out of 82 R-/D+ seroconverted after chemoprophylaxis interruption. There was no difference between matched and mismatched recipients as to the frequency of seroconversion which therefore could not be related to donor seropositivity. Seroconversions were almost asymptomatic. All positive recipients should be tested if symptoms of infection are present.
authors.affiliation: Infectious Diseases Department, University of Pavia, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Sarchi
authors.forename: Francesca
authors.initials: F
authors.lastname: Genco
authors.forename: Angela
authors.initials: A
authors.lastname: Di Matteo
authors.forename: Barbara
authors.initials: B
authors.lastname: Castiglioni
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Minoli
authors.forename: Valeria
authors.initials: V
authors.lastname: Meroni
mesh_terms: D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D007118:Immunoassay; D007558:Italy / Q000453:epidemiology; D016040:Lung Transplantation; D008297:Male; D011739:Pyrimethamine / Q000627:therapeutic use; D011933:Reagent Kits, Diagnostic; D018571:Sentinel Surveillance; D016036:Seroepidemiologic Studies; D013415:Sulfalene / Q000627:therapeutic use; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D016896:Treatment Outcome