title: Prevalence and factors associated with dyslipoproteinemias in Brazilian systemic lupus erythematosus patients.
abstract: To determine the prevalence of dyslipoproteinemias and their related factors in a Brazilian systemic lupus erythematosus (SLE) population, fasting lipids were measured in 185 female SLE outpatients. Age, BMI, smoking, post-menopausal status, presence of diabetes and hypertension, SLE duration, number of ARA criteria, drug treatment and disease activity (by SLEDAI) were registered. Statistics included uni and multivariate logistic regression. Eighty-nine patients (48.1%) had hypercholesterolemia, 55 (29.7%) had hypertriglyceridemia and 109 (58.9%) had either. On multivariate analysis, 24-h proteinuria (OR = 2.08, 95% CI: 1.11-3.88), BMI (OR = 1.08, 95% CI: 1.01-1.16) and post-menopausal status (OR = 2.48, 95% CI: 1.25-4.92) were associated with hypercholesterolemia. Disease activity was related to low HDL-cholesterol (OR = 2.59, 95% CI: 1.20-5.58) and, in pre-menopausal patients, also to hypertriglyceridemia (OR = 1.16, 95% CI: 1.03-1.30). Antimalarial use was protective for hypertriglyceridemia (OR = 0.44, 95% CI: 0.22-0.90). In conclusion, the increased prevalence of dyslipoproteinemias is due to proteinuria, obesity and SLE activity. Antimalarials have beneficial effect on lipid profile that may be due to reduction in disease activity.
authors.affiliation: Department of Internal Medicine, Clementino Fraga Filho University Hospital, Medical School, Federal University of Rio de Janeiro, Rua Cróton, 72, Jacarepagua, CEP 22750-240, Rio de Janeiro, Brazil. claudiacardoso@hucff.ufrj.br
authors.forename: Claudia R L
authors.initials: CR
authors.lastname: Cardoso
authors.forename: Flávio V
authors.initials: FV
authors.lastname: Signorelli
authors.forename: Jose A
authors.initials: JA
authors.lastname: Papi
authors.forename: Gil F
authors.initials: GF
authors.lastname: Salles
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000208:ethnology* / Q000209:etiology* / Q000517:prevention & control; D015228:Hypertriglyceridemia / Q000208:ethnology* / Q000209:etiology* / Q000517:prevention & control; D016015:Logistic Models; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000208:ethnology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000208:ethnology; D016017:Odds Ratio; D017698:Postmenopause / Q000208:ethnology; D015995:Prevalence; D011507:Proteinuria / Q000150:complications / Q000208:ethnology; D018570:Risk Assessment; D012307:Risk Factors