title: Biological and clinical relevance of anti-prothrombin antibodies.
abstract: Anti-prothrombin (anti-PT) antibodies are recently identified antibodies directed toward a phospholipid-binding protein (prothrombin), which deserve attention for the reported clinical and pathogenic relevance in antiphospholipid syndrome and systemic lupus erythematosus (SLE). We have recently carried out a longitudinal study on the predictive value of anti-PT antibodies in SLE showing that they have a higher diagnostic accuracy for thrombosis than anti-beta(2)-GPI and anticardiolipin antibodies, and, along with LAC activity, are the best predictors of thromboembolic events in SLE patients.
authors.affiliation: Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Ghirardello
authors.forename: Nicola
authors.initials: N
authors.lastname: Bizzaro
authors.forename: Sandra
authors.initials: S
authors.lastname: Zampieri
authors.forename: Luca
authors.initials: L
authors.lastname: Iaccarino
authors.forename: Nicola
authors.initials: N
authors.lastname: Bassi
authors.forename: Renato
authors.initials: R
authors.lastname: Tozzoli
authors.forename: Amelia
authors.initials: A
authors.lastname: Ruffatti
authors.forename: Danilo
authors.initials: D
authors.lastname: Villalta
authors.forename: Elio
authors.initials: E
authors.lastname: Tonutti
authors.forename: Andrea
authors.initials: A
authors.lastname: Doria
mesh_terms: D000906:Antibodies / Q000097:blood* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D011516:Prothrombin / Q000276:immunology*