[Endothelial dysfunction and renal lesion in obesity].
The subjects of the study were 29 men (mean age 37.7+/-9.3 years) suffering from abdominal obesity without carbohydrate exchange disturbances or signs of chronic renal diseases. The results of the study show that the surplus of leptin, typical of obese patients, leads to the development of intrarenal vascular endothelial dysfunction, which is manifested by microalbuminuria, the growth of endothelin-1 serum level, and endothelium-dependent vasodilatation impairment, leading to unfavorable changes in renal filtration. Administration of angiotensin II receptor blockers results in the elimination of microalbuminuria and the recovery of endothelium-dependent vasodilatation in obese patients.
Mukhin
N A
NA
Fomin
V V
VV
Saginova
E A
EA
Moiseev
S V
SV
Kutyrina
I M
IM
Lebedeva
M V
MV
Minakova
E G
EG
Gitel'
E P
EP
Samokhodskaia
L M
LM
Domracheva
T S
TS
D000328:Adult; D000419:Albuminuria / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D019332:Endothelin-1 / Q000097:blood; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D011379:Prognosis; D012079:Renal Circulation / Q000187:drug effects / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*