title: On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition.
abstract: Cyclic peptides were obtained, on-resin, by the copper (I) catalysed 1,3-dipolar cycloaddition of azides and alkynes. The reaction led exclusively to the formation of the expected cyclomonomeric products which acted as ligands of the Vascular Endothelial Growth Factor receptor 1.
authors.affiliation: Université Paris Descartes, UFR biomédicale, Laboratoire de Pharmacochimie Moléculaire et Cellulaire, 45 rue des saints Pères, F-75006 Paris, France.
authors.forename: Victor
authors.initials: V
authors.lastname: Goncalves
authors.forename: Benoit
authors.initials: B
authors.lastname: Gautier
authors.forename: Anne
authors.initials: A
authors.lastname: Regazzetti
authors.forename: Pascale
authors.initials: P
authors.lastname: Coric
authors.forename: Serge
authors.initials: S
authors.lastname: Bouaziz
authors.forename: Christiane
authors.initials: C
authors.lastname: Garbay
authors.forename: Michel
authors.initials: M
authors.lastname: Vidal
authors.forename: Nicolas
authors.initials: N
authors.lastname: Inguimbert
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000595:Amino Acid Sequence; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D042461:Vascular Endothelial Growth Factor A / Q000737:chemistry / Q000378:metabolism; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000737:chemistry* / Q000378:metabolism*