title: Clinical applications of rhBMP-2 in maxillofacial surgery.
abstract: METHODS
  Examples of defects including mandibular continuity defects, preprosthetic atrophic alveolar ridge deficiencies, traumatic defects, and maxillary clefts were included.
  
  
  RESULTS
  All patients demonstrated osseous regeneration stimulated by rhBMP-2.
  
  
  CONCLUSIONS
  rhBMP-2 is successful in regenerating bone in a variety of maxillofacial defects. In the future, rhBMP-2 will play a significant role in the treatment of bone deficiencies.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Loma Linda University School of Dentistry, Loma Linda, CA 92350, USA.
authors.forename: Alan S
authors.initials: AS
authors.lastname: Herford
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Boyne
authors.forename: Roland P
authors.initials: RP
authors.lastname: Williams
mesh_terms: D000293:Adolescent; D000540:Alveolar Ridge Augmentation / Q000379:methods; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation / Q000379:methods; D002648:Child; D002972:Cleft Palate / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000601:surgery; D008437:Maxilla / Q000601:surgery; D008446:Maxillofacial Injuries / Q000601:surgery; D008875:Middle Aged; D019647:Oral Surgical Procedures; D011994:Recombinant Proteins / Q000627:therapeutic use*; D019651:Plastic Surgery Procedures; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D014948:Wounds, Gunshot / Q000601:surgery