title: Effect of Vaccinium ashei reade leaves on angiotensin converting enzyme activity in vitro and on systolic blood pressure of spontaneously hypertensive rats in vivo.
abstract: The hypotensive effects of Vaccinium ashei reade (blueberry) leaves were studied in vitro and in vivo. Blueberry leaf showed a strong inhibitory effect on angiotensin-converting enzyme activity in vitro. Additionally, feeding of blueberry leaf suppressed the development of essential hypertension in spontaneously hypertensive rats in vivo. These results promise the use of blueberry leaf as a source of dietary hypotensive components.
authors.affiliation: Research Institute, Unkai Shuzo Co., Ltd, 1800-5 Oaza Minamimata, Miyazaki 880-1303, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakaida
authors.forename: Koji
authors.initials: K
authors.lastname: Nagao
authors.forename: Kouki
authors.initials: K
authors.lastname: Higa
authors.forename: Bungo
authors.initials: B
authors.lastname: Shirouchi
authors.forename: Nao
authors.initials: N
authors.lastname: Inoue
authors.forename: Fumie
authors.initials: F
authors.lastname: Hidaka
authors.forename: Takanori
authors.initials: T
authors.lastname: Kai
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Yanagita
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D029798:Blueberry Plants / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats