Involvement of p38 Mapkinase in attenuation of antinociceptive effect of morphine in diabetic mice.
Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.
Gilhotra
Neeraj
N
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147 002, India. neeraj_gilhotra@yahoo.co.in
Sharma
Ajay
A
Singh
Manjeet
M
D000700:Analgesics / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D005260:Female; D008297:Male; D051379:Mice; D015233:Models, Statistical; D009020:Morphine / Q000494:pharmacology*; D009573:Nitrites / Q000737:chemistry / Q000378:metabolism / Q000652:urine; D011720:Pyrazoles / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*