title: New advances in nanomedicine: diagnosis and preventive medicine.
abstract: This article describes the use of nanobiologic techniques in diagnosis and preventive medicine. It discusses the engineering of fluorescent and bioluminescent proteins to visualize biologic functions; single-molecule measurements of protein structure and function; two-photon microscopy for molecular imaging of the structure and function in living cells and tissues; and imaging ligand-induced protein conformations and interactions by fluorescence in single living cells.
authors.affiliation: Department of Surgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street/Harvey 606, Baltimore, MD 21205, USA. chimingwei@gmail.com
authors.forename: Chiming
authors.initials: C
authors.lastname: Wei
authors.forename: Takeharu
authors.initials: T
authors.lastname: Nagai
authors.forename: Wenchi
authors.initials: W
authors.lastname: Wei
authors.forename: Tomomi
authors.initials: T
authors.lastname: Nemoto
authors.forename: Muhammad
authors.initials: M
authors.lastname: Awais
authors.forename: Osamu
authors.initials: O
authors.lastname: Niwa
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kurita
authors.forename: Yashinobu
authors.initials: Y
authors.lastname: Baba
mesh_terms: D000818:Animals; D019937:Diagnostic Techniques and Procedures / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D050997:Nanomedicine / Q000379:methods / Q000639:trends*; D049329:Nanostructures; D011315:Preventive Medicine / Q000295:instrumentation*