Rapid human immunodeficiency virus-1 testing on labor and delivery in 17 US hospitals: the MIRIAD experience.
The objective of the study was to evaluate the feasibility, acceptability, and accuracy of rapid human immunodeficiency virus (HIV) testing during labor. The Mother-Infant Rapid Intervention at Delivery (MIRIAD) study was a prospective, multicenter study that offered voluntary, rapid HIV testing to women with undocumented HIV status at 17 hospitals in 6 cities. Of 12,481 eligible women, 74% were approached for participation and 85.5% of those approached accepted rapid HIV testing. Among 7753 women tested, MIRIAD identified 52 (0.7%) HIV-infected women. The time between obtaining the blood sample for the rapid test and reporting the results to the health care provider was shorter for hospitals utilizing point-of-care testing than in hospitals utilizing laboratory-based testing (30 minutes vs 68 minutes; P < .0001), and point-of-care testing strategies were 14 times more likely to have a short turnaround as laboratory testing strategies. Routine rapid testing during labor provides a feasible, acceptable, and accurate way to identify HIV-infected women before delivery.
Jamieson
Denise J
DJ
Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. djj0@cdc.gov
Cohen
Mardge H
MH
Maupin
Robert
R
Nesheim
Steven
S
Danner
Susan P
SP
Lampe
Margaret A
MA
O'Sullivan
Mary Jo
MJ
Webber
Mayris P
MP
Wiener
Jeffrey
J
Carter
Rosalind J
RJ
Rivero
Yvette
Y
Fowler
Mary Glenn
MG
Bulterys
Marc
M
D000328:Adult; D019411:Clinical Laboratory Techniques; D036861:Delivery, Obstetric; D005240:Feasibility Studies; D005260:Female; D015658:HIV Infections / Q000175:diagnosis*; D015497:HIV-1; D006761:Hospitals; D006801:Humans; D007124:Immunoenzyme Techniques; D007743:Labor, Obstetric / Q000097:blood*; D019095:Point-of-Care Systems; D011247:Pregnancy; D011446:Prospective Studies; D013997:Time Factors; D014481:United States