title: Cytotoxic turrianes of Kermadecia elliptica from the New Caledonian rainforest.
abstract: In the course of an automated screening for small molecules presenting cytotoxic activity, eight new cyclophanes named kermadecins A-H (1-8), have been isolated from the bark of a New Caledonian plant, Kermadecia elliptica, Proteaceae. A LC/APCI-MS study performed on kermadecins A, B and C, provided a reliable method for the detection of other analogues existing in small quantities in the extract. This led to the isolation of five other members of this chemical series. The structures were elucidated by extensive mono- and bi-dimensional spectroscopy and mass spectrometry. The cytotoxic activity of four of them was evaluated on various cell lines.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Jolly
authors.forename: Odile
authors.initials: O
authors.lastname: Thoison
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Martin
authors.forename: Vincent
authors.initials: V
authors.lastname: Dumontet
authors.forename: Aline
authors.initials: A
authors.lastname: Gilbert
authors.forename: Bruno
authors.initials: B
authors.lastname: Pfeiffer
authors.forename: Stéphane
authors.initials: S
authors.lastname: Léonce
authors.forename: Thierry
authors.initials: T
authors.lastname: Sévenet
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009510:New Caledonia; D011891:Rain; D014329:Tropical Climate