title: (S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity.
abstract: (S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.
authors.forename: E
authors.initials: E
authors.lastname: DE Clercq
authors.forename: J
authors.initials: J
authors.lastname: Descamps
authors.forename: P
authors.initials: P
authors.lastname: DE Somer
authors.forename: A
authors.initials: A
authors.lastname: Holyacute