title: Nanoparticles for drug delivery: the need for precision in reporting particle size parameters.
abstract: Polymeric drug-loaded nanoparticles have been extensively studied in the field of drug delivery. Biodistribution depends on the physicochemical properties of particles, especially size. The global message from the literature is that small particles have an enhanced ability to reach their target. The present review highlights the difficulties in validating the data from biodistribution studies without accurate particle size determination.
authors.affiliation: Department of Pharmaceutics and Biopharmaceutics, University of Geneva, University of Lausanne, Geneva, Switzerland.
authors.forename: Marie
authors.initials: M
authors.lastname: Gaumet
authors.forename: Angelica
authors.initials: A
authors.lastname: Vargas
authors.forename: Robert
authors.initials: R
authors.lastname: Gurny
authors.forename: Florence
authors.initials: F
authors.lastname: Delie
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004345:Drug Industry / Q000639:trends; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical