Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors.
We report a robust regulation of surface AMPA receptors in mouse auditory neurons, both with application of glutamate receptor agonists in cultured neurons and in response to acoustic stimulation in vivo. The reversible reduction of surface AMPA receptors following acoustic stimulation correlated with changes in acoustic sensitivity. Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body.
Chen
Zhiqiang
Z
Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA.
Kujawa
Sharon G
SG
Sewell
William F
WF
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D000831:Animals, Newborn; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology*; D004307:Dose-Response Relationship, Radiation; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000528:radiation effects; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D009475:Neurons, Afferent / Q000187:drug effects / Q000378:metabolism*; D018091:Receptors, AMPA / Q000378:metabolism*; D013136:Spiral Ganglion / Q000166:cytology; D013997:Time Factors