[Immunomodulating activity of dental materials used for filling of dental root canals].
In experiments on mice immunomodulating activity of root canal pastes (Septodent, Foredent and Sealite Regular) was studied concerning immune response to model allergen. In order to study immunomodulating effect of root canal pastes the authors have used the model of standardized immunization by model allergen ovalbumin (OA) of mice (CBA x C57BL/6)F1. OA (Sigma) was used as model allergen in all experiments both for mice immunization and for testing anti-OA IgE- and IgG-antibodies in reaction of passive skin anaphylaxis in rats and in reaction ELISA. It was established that the tested pastes led to changes in antibody formation dynamics of the IgE- and IgG-classes, at that some of them produced immunosuppression. In that way root pastes could weaken immune protection increasing risk of different diseases rise.
Volozhina
A I
AI
Babakhin
A A
AA
Kazarina
L N
LN
Gushchina
O O
OO
Dubova
L V
LV
Babakhina
Iu A
IuA
Bondarenko
M O
MO
D000485:Allergens / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000097:blood; D000917:Antibody Formation / Q000187:drug effects*; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D051379:Mice; D008815:Mice, Inbred Strains; D010047:Ovalbumin / Q000276:immunology; D012387:Root Canal Filling Materials / Q000633:toxicity*