title: Phrenic nerve conduction in the early stage of Guillain-Barre syndrome might predict the respiratory failure.
abstract: OBJECTIVE
  To investigate whether phrenic nerve conduction in the early phase of Guillain- Barre syndrome (GBS) predicts the need for respiratory assistance during the subsequent clinical course.
  
  
  METHODS
  We performed electrophysiological examinations of conventional peripheral nerve conduction and phrenic nerve conduction for GBS patients within 14 days from the onset. We excluded patients who had already been treated with immuno-related therapy and respiratory assistance.
  
  
  RESULTS
  Fifteen patients were enrolled. Three patients with the sum of phrenic nerve latency longer than 30 ms and the sum of bilateral diaphragmatic compound muscle action potential amplitude smaller than 0.3 mV required respiratory assistance after the conduction test.
  
  
  CONCLUSIONS
  Our findings showed that not only delayed distal latency but also decreased amplitude may predict the need for respiratory assistance during the subsequent disease course.
authors.affiliation: Department of Neurology, Tokyo-west Tokushukai Hospital, Akishima, Tokyo, Japan. hisashi.ito@tokushukai.jp
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Takanashi
authors.forename: H
authors.initials: H
authors.lastname: Kusaka
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D005260:Female; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020380:Needs Assessment; D009431:Neural Conduction / Q000502:physiology*; D010791:Phrenic Nerve / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000628:therapy