title: Purpura fulminans skin loss: surgical management protocols at a regional burns centre.
abstract: People with significant skin loss after sepsis frequently require skin grafting; as such, they are often referred to regional burns units for definitive soft-tissue cover. Such individuals have complex requirements after severe sepsis, and usually have complicated wounds. We have developed a protocol for managing these patients and their wounds within a high dependency, intensive-care unit, using allograft as an adjunct in preparing the tissue bed before autografting. This protocol includes optimisation of nutritional needs, microbiological surveillance and definitive soft tissue cover. We retrospectively reviewed all children referred over 18 months for management of skin and soft tissue loss after meningitis purpura fulminans. We reviewed the initial management of the septicaemia, associated co-morbidities, site and size of soft tissue defect, time to presentation for definitive skin cover, surgical procedure performed, timing of surgical intervention, and recovery of the patient's wounds. A total of six people (all children), with a mean age of 7 months (age range 4-21 years) were admitted to our unit between March 2004 and September 2005. Total percentage skin loss was 12% (6-20%). All of the children underwent debridement, received allograft to areas of skin loss and necrosis as a primary procedure, and subsequently underwent autograft. Two children required amputation of one or more limbs, and the stumps were covered with allograft followed by skin autograft. All patients had excellent autograft skin taken using this protocol.
authors.affiliation: St Andrews Centre for Burns and Plastic Surgery, Broomfield Hospital, Chelmsford, Essex, UK.
authors.forename: K
authors.initials: K
authors.lastname: Lowery
authors.forename: R
authors.initials: R
authors.lastname: Shirley
authors.forename: O P
authors.initials: OP
authors.lastname: Shelley
authors.forename: M
authors.initials: M
authors.lastname: Kaniorou-Larai
authors.forename: B
authors.initials: B
authors.lastname: Philp
authors.forename: P
authors.initials: P
authors.lastname: Dziewulski
mesh_terms: D000671:Amputation, Surgical / Q000379:methods; D000672:Amputation Stumps / Q000601:surgery; D002053:Burn Units; D002985:Clinical Protocols; D006801:Humans; D007223:Infant; D008585:Meningitis, Meningococcal / Q000150:complications; D055665:Purpura Fulminans / Q000382:microbiology / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D016038:Skin Transplantation / Q000379:methods*