Silyamandin, a new flavonolignan isolated from milk thistle tinctures.
Our investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2 R,3 R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic acid called silyamandin (1). Incubation of the tincture at 40 degrees C for 3 months resulted in an increase in the level of this compound, as observed in the LC/DAD silymarin profile.
MacKinnon
Shawna L
SL
National Research Council Canada, Institute for Marine Biosciences, Halifax, NS, Canada. shawna.mackinnon@nrc-cnrc.gc.ca
Hodder
Mark
M
Craft
Cheryl
C
Simmons-Boyce
Joanne
J
D047309:Flavones / Q000737:chemistry; D044947:Flavonolignans / Q000737:chemistry*; D005638:Fruit; D006801:Humans; D017705:Lignans / Q000737:chemistry; D020944:Silybum marianum; D008517:Phytotherapy