title: The influence of porosity on the integration histology of two polypropylene meshes for the treatment of abdominal wall defects in dogs.
abstract: Two types of monofilament polypropylene mesh with different pore sizes, mass densities and burst strengths were used to repair two identical paired full-thickness abdominal wall defects in ten dogs, in order to compare their integration histology 90 days after implantation. On one side a standard mesh, Prolene (Ethicon), was sutured to the borders of the defect, while on the other a new ultralightweight macroporous mesh, Mpathy mesh, was used. There was a significantly greater densitometric proportion of mature (type I) collagen (58.38%) for Mpathy mesh compared to Prolene (34.05%, P=0.01). Although Prolene has 3.6 times the burst strength of Mpathy mesh, the implanted tissue strength was marginally greater for Mpathy mesh. We conclude that Mpathy mesh gives a surgical repair that is at least as strong as that provided by Prolene, along with a higher concentration of mature collagen and less fibrosis (P=0.07), in this canine histology model.
authors.affiliation: Experimental Surgery Department, Pontifical Catholic University of Paraná, Paraná, Brazil. fernando.greca@bbs2.sul.com.br
authors.forename: F H
authors.initials: FH
authors.lastname: Greca
authors.forename: Z A
authors.initials: ZA
authors.lastname: Souza-Filho
authors.forename: A
authors.initials: A
authors.lastname: Giovanini
authors.forename: M R
authors.initials: MR
authors.lastname: Rubin
authors.forename: R F
authors.initials: RF
authors.lastname: Kuenzer
authors.forename: F B
authors.initials: FB
authors.lastname: Reese
authors.forename: L M
authors.initials: LM
authors.lastname: Araujo
mesh_terms: D000818:Animals; D003094:Collagen; D004285:Dogs; D046449:Hernia, Abdominal / Q000601:surgery*; D011126:Polypropylenes; D016062:Porosity; D011183:Postoperative Complications; D013526:Surgical Mesh