Effect of isoflurane anesthesia on hemodynamics following the administration of an angiotensin-converting enzyme inhibitor in cats.
The objective of this study was to evaluate the hemodynamics of the anesthetic isoflurane in healthy cats given angiotensin-converting enzyme inhibitor (ACEI). The 7 healthy young cats and 3 old cats were received placebo or enalapril 0.5 mg/kg orally. The change in systolic arterial pressure from the baseline to 30 min postanesthesia in the ACEI group was significantly higher than in the placebo group (mean +/- SD: -39 +/- 13% vs. -17 +/- 12%, respectively). The present study indicated that general anesthesia may induce hypotension after the administration of an ACEI.
Ishikawa
Yumi
Y
Ishikawa Animal Hospital, Yokosuka, Kanagawa, Japan.
Uechi
Masami
M
Ishikawa
Ryoukichi
R
Wakao
Yoshito
Y
Higuchi
Sei-ichi
S
D000758:Anesthesia / Q000009:adverse effects / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000009:adverse effects / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004656:Enalapril / Q000008:administration & dosage / Q000494:pharmacology; D007022:Hypotension / Q000139:chemically induced / Q000503:physiopathology; D007530:Isoflurane / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors