Orally administered bisphenol A disturbed antigen specific immunoresponses in the naïve condition.
Bisphenol A [2,2-bis(4-hydoxyphenyl)propane; BPA] is an endocrine disrupter widely used in polycarbonate plastics and epoxy resins. We investigated the effects of orally administered BPA on antigen-specific responses of the naïve immune system.BPA was orally administered to T cell receptor transgenic mice, and the antigen-specific responses of immune cells were investigated. Administered BPA moderately reduced interleukin (IL)-2, 4, and interferon (IFN)-gamma secretion and increases in IgA and IgG2a production.Additionally, it was found that orally administered BPA increased antigen-specific IFN-gamma production of T cells and modified whole antigen presenting cells (APCs) to suppress antigen-specific cytokine production from T cells. These findings suggest that BPA can augment the Th1-type responses of naïve immune systems, though the bioavailability of orally administered BPA was low in our experiments.
Goto
Masao
M
National Agriculture and Food Research Organization National Food Research Institute, 2-1-12 Kan-nondai, Tsukuba, Ibaraki 305-8642, Japan.
Takano-Ishikawa
Yuko
Y
Ono
Hiroshi
H
Yoshida
Mitsuru
M
Yamaki
Kohji
K
Shinmoto
Hiroshi
H
D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D000918:Antibody Specificity; D000938:Antigen-Presenting Cells / Q000187:drug effects / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D001559:Benzhydryl Compounds; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D018920:Coculture Techniques; D016207:Cytokines / Q000378:metabolism; D007113:Immunity, Innate / Q000187:drug effects* / Q000276:immunology*; D051379:Mice; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D000098826:Bisphenol A Compounds