title: Frequency, determinants, and clinical relevance of acute coronary syndrome-like electrocardiographic findings in patients with acute aortic syndrome.
abstract: We investigated frequency/characteristics of acute coronary syndrome-like (ACS-like) electrocardiographic (ECG) profiles among patients with a final diagnosis of acute aortic syndrome (AAS), and explored pathophysiologic determinants and prognostic relevance within each Stanford subtype. We blindly reviewed presentation electrocardiograms of 233 consecutive patients with final diagnosis of AAS (164 Stanford type A) at a regional treatment center. Prevalence of ACS-like ECG findings was 27% (type A, 26%, type B, 29%); most were non-ST-elevation myocardial infarction-like. Patients with ACS-like ECG findings more often had coronary ostia involvement (p=0.002), pleural effusion (p=0.02), significant aortic regurgitation (p=0.01), and troponin positivity (p=0.001). ACS-like ECG profile in type A disease was independently associated with coronary ostia involvement (odds ratio [OR] 5.27, 95% confidence interval [CI] 1.75 to 15.88). ACS-like ECG profile predicted in-hospital mortality (OR 2.90, 95% CI 1.24 to 6.12), as did age (each incremental 10-year: OR 1.59, 95% CI 1.14 to 2.22), and syncope at presentation (OR 2.90, 95% CI 1.16 to 7.24). In conclusion, about 25% of our AAS patients (in either Stanford subtype) presented ACS-like ECG patterns-often with non-ST-elevation myocardial infarction characteristics-which could cause misdiagnosis. ACS-like ECG profile was associated with more complicated disease, and in type A disease was a strong independent predictor of in-hospital mortality.
authors.affiliation: Institute of Cardiology, Cardiovascular Radiology Unit, Cardiothoracic Department, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Biagini
authors.forename: Carla
authors.initials: C
authors.lastname: Lofiego
authors.forename: Marinella
authors.initials: M
authors.lastname: Ferlito
authors.forename: Rossella
authors.initials: R
authors.lastname: Fattori
authors.forename: Guido
authors.initials: G
authors.lastname: Rocchi
authors.forename: Maddalena
authors.initials: M
authors.lastname: Graziosi
authors.forename: Luigi
authors.initials: L
authors.lastname: Lovato
authors.forename: Lara
authors.initials: L
authors.lastname: di Diodoro
authors.forename: Robin M T
authors.initials: RM
authors.lastname: Cooke
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Petracci
authors.forename: Letizia
authors.initials: L
authors.lastname: Bacchi-Reggiani
authors.forename: Romano
authors.initials: R
authors.lastname: Zannoli
authors.forename: Angelo
authors.initials: A
authors.lastname: Branzi
authors.forename: Claudio
authors.initials: C
authors.lastname: Rapezzi
mesh_terms: D000368:Aged; D000784:Aortic Dissection; D000789:Angina, Unstable / Q000175:diagnosis*; D001014:Aortic Aneurysm / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies; D013577:Syndrome; D019210:Troponin I / Q000097:blood