Antibacterial stilbenoids from the roots of Stemona tuberosa.
Twelve dihydrostilbenes, stilbostemins N-Y (1-12), and a phenanthraquinone, stemanthraquinone (13), were isolated and identified from roots of Stemona tuberosa, along with five known dihydrostilbenes. Their structures were established on the basis of 1D and 2D NMR and other spectroscopic analyses. Dihydrostilbene 8 exhibited strong activity against Bacillus pumilus (MIT 12.5-25 microg/mL). Many tested compounds exhibited moderate antibacterial activities.
Lin
Li-Gen
LG
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Zhangjiang Hi-tech Park, Shanghai 201203, PR China.
Yang
Xin-Zhou
XZ
Tang
Chun-Ping
CP
Ke
Chang-Qiang
CQ
Zhang
Ji-Bao
JB
Ye
Yang
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D041901:Stemonaceae / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*