title: Catalysis by Imidazole of Deuterium-Hydrogen Exchange in Amide N-H Groups.
abstract: Imidazole, at concentrations of 0.05M to 0.2M, has been found to increase the rate of deuterium-hydrogen exchange in a model amide by 40-fold or more. Since imidazole side-chains occur in proteins, deuterium exchange in these macromolecules may be strongly affected by the presence of these or similar activating groups.
authors.forename: I M
authors.initials: IM
authors.lastname: Klotz
authors.forename: B H
authors.initials: BH
authors.lastname: Frank