title: Soft tissue abscess and lymphadenitis due to Mycobacterium avium complex as an expression of immune reconstitution inflammatory syndrome after a second scheme of highly active antiretroviral therapy.
abstract: Immune reconstitution inflammatory syndrome (IRIS) is an atypical and unexpected reaction related to highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV) infected patients. IRIS includes an atypical response to an opportunistic pathogen (generally Mycobacterium tuberculosis, Mycobacterium avium complex, cytomegalovirus and herpes varicella-zoster), in patients responding to HAART with a reduction of plasma viral load and evidence of immune restoration based on increase of CD4+ T-cell count. We reported a case of a patient with AIDS which, after a first failure of HAART, developed a subcutaneous abscess and supraclavicular lymphadenitis as an expression of IRIS due to Mycobacterium avium complex after starting a second scheme of HAART.
authors.affiliation: Division of HIV/AIDS, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina. marcelocorti@fibertel.com.ar
authors.forename: Marcelo
authors.initials: M
authors.lastname: Corti
authors.forename: María F
authors.initials: MF
authors.lastname: Villafañe
authors.forename: Marta
authors.initials: M
authors.lastname: Ambroggi
authors.forename: Mirna
authors.initials: M
authors.lastname: Sawicki
authors.forename: Elisa
authors.initials: E
authors.lastname: Gancedo
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D000038:Abscess / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D006801:Humans; D008199:Lymphadenitis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D019562:Viral Load