Prophylaxis and treatment of chronic synovitis in haemophilia patients with inhibitors.
Prophylaxis is paramount to try to avoid the development of haemophilic synovitis. The best treatment for synovitis in patients with inhibitors is radioactive synoviorthesis (rhenium for ankle and elbows, yttrium for knees). With both methods (prohylaxis and radioactive synoviorthesis), we can delay the development of severe haemophilic arthropathy, that eventually will require major orthopaedic surgery.
Rodriguez-Merchan
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Department of Orthopaedics and Haemophilia Unit, La Paz University Hospital, Madrid, Spain. rmerchan@arrakis.es
Valentino
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Quintana
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D005164:Factor IX / Q000627:therapeutic use*; D005167:Factor VII / Q000627:therapeutic use*; D005260:Female; D006395:Hemarthrosis / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D006467:Hemophilia A / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011868:Radioisotopes / Q000627:therapeutic use; D012211:Rhenium / Q000627:therapeutic use; D013585:Synovitis / Q000188:drug therapy / Q000517:prevention & control / Q000601:surgery*; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use