[Some mechanisms of a recurrent course of stenosing laryngotracheitis in children].
Staged development of dysbiotic disturbance of the upper airways was revealed in children suffering from stenosing laryngotracheitis in the presence of viral infection. Chronic persistent virus-bacterial inflammation of respiratory tract mucosa and resultant hypersensitivity of the airways produce chronic defects in lung ventilation in patients with recurrent stenosing laryngotracheitis. High sensitivity of the airways to histamine is related to bioelectric activity of the brain characterized by dominant irritation of the mesencephalo-diencephalic structures. Typical features of the curve flow-volume and paradoxic result of the test with broncholytic drugs verified tracheobronchial dyskinesia in patients with stenosing laryngotracheitis. Such dyskinesia promoted the recurrent disease with transformation into bronchial asthma.
Orlova
S N
SN
Ryvkin
A I
AI
Pobedinskaia
N S
NS
D000914:Antibodies, Viral / Q000276:immunology; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D004027:Diencephalon / Q000503:physiopathology; D004569:Electroencephalography; D005500:Follow-Up Studies; D006801:Humans; D007827:Laryngitis / Q000150:complications* / Q000503:physiopathology / Q000821:virology; D007829:Laryngostenosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D008636:Mesencephalon / Q000503:physiopathology; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D014135:Tracheal Stenosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D014136:Tracheitis / Q000150:complications* / Q000503:physiopathology / Q000821:virology; D014777:Virus Diseases / Q000150:complications* / Q000503:physiopathology / Q000821:virology; D014780:Viruses / Q000276:immunology