[Impact of protamine sulfate on hemostasis system after operations with artificial circulation].
Effects of different doses and lots of protamine sulfate on hemostasis system after cardiac operations with artificial circulation are analyzed. Overall 982 patients underwent cardiac operations with artificial circulation. Quality and purity of protamine may be the causes of side effects. Negative effect of high doses of protamine on hemostasis system is demonstrated. Thrombocyte dysfunction is the main cause of intensive postoperative bleeding after administration of protamine high doses.
Charnaia
M A
MA
Klypa
T V
TV
Morozov
Iu A
IuA
Shmerko
N P
NP
Gladysheva
V G
VG
Andriianova
A A
AA
D006348:Cardiac Surgical Procedures / Q000379:methods*; D004334:Drug Administration Schedule; D005112:Extracorporeal Circulation / Q000379:methods*; D006488:Hemostasis, Surgical; D006494:Heparin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications; D011479:Protamines / Q000494:pharmacology* / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*