Relaxation of canine airway smooth muscle.
Relaxation of airway smooth muscle is an inadequately understood yet critical process that, if impaired, may have significant implications for asthma. Here we explore why relaxation is an important process to consider, how it may determine airway hyperresponsiveness, and some of the factors that influence relaxation of the airway smooth muscle. These include mechanical and biochemical factors such as deep inspirations or large amplitude oscillation of the muscle, plastic properties of the muscle, the load the muscle experiences, calcium, phosphorylation of the myosin light chain, cytoskeletal proteins, and sensitization.
Fust
Anita
A
Department of Physiology, University of Manitoba, Winnipeg, MB, Canada. afust@mich.ca
Stephens
Newman L
NL
D000818:Animals; D001249:Asthma / Q000378:metabolism / Q000503:physiopathology; D003598:Cytoskeletal Proteins / Q000378:metabolism; D004285:Dogs; D008168:Lung / Q000378:metabolism / Q000502:physiology*; D009124:Muscle Proteins / Q000378:metabolism; D009126:Muscle Relaxation / Q000502:physiology*; D009130:Muscle, Smooth / Q000378:metabolism / Q000502:physiology*; D018994:Myosin Light Chains / Q000378:metabolism