Combined effect of the essential oil from Chenopodium ambrosioides and antileishmanial drugs on promastigotes of Leishmania amazonensis.
To date, there are no vaccines against Leishmania, and chemotherapy remains the mainstay for the control of leishmaniasis. The drugs of choice used for leishmaniasis therapy are significantly toxic, expensive and with a growing frequency of refractory infections. Because of these limitations, a combination therapy is the better hope. This work demonstrates that the essential oil from Chenopodium ambrosioides shows a synergic activity after incubation in conjunction with pentamidine against promastigotes of Leishmania amazonensis. However, an indifferent effect has been found for combinations of meglumine antimoniate or amphotericin B and the essential oil.
Monzote
Lianet
L
Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Ciudad de la Habana, Cuba. monzote@ipk.sld.cu
Montalvo
Ana Margarita
AM
Scull
Ramón
R
Miranda
Migdalia
M
Abreu
Juan
J
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D027464:Chenopodium ambrosioides / Q000737:chemistry*; D004357:Drug Synergism; D007891:Leishmania / Q000187:drug effects*; D008536:Meglumine / Q000494:pharmacology; D000077485:Meglumine Antimoniate; D051379:Mice; D009822:Oils, Volatile / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D010419:Pentamidine / Q000494:pharmacology; D010938:Plant Oils / Q000494:pharmacology*