title: Wegener's granulomatosis complicated by intestinal ulcer due to cytomegalovirus infection and by thrombotic thrombocytopenic purpura.
abstract: A 61-year-old woman was admitted to our hospital because of acute kidney injury. She complained of general fatigue, appetite loss, and a high fever. Nodular lesions were observed on chest X-rays and there were >100 erythrocytes per high power field in her urinary sediment. A renal biopsy revealed necrotizing granulomatous glomerulonephritis, and her serum proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) titer was elevated (55 EU). Based on these findings we made a diagnosis of Wegener's granulomatosis (WG). Hemodialysis was started immediately after admission. Steroid therapy was administered and her symptoms were relieved, but her renal function did not improve. On the 50th hospital day her condition suddenly became complicated by hemoperitoneum and massive intestinal bleeding, and the descending, transverse, ascending colon and part of the ileum were surgically resected. The cytomegalovirus (CMV) antigen titer was elevated, and histologic examination of the bowel specimen showed positive staining for CMV in the ulcer lesion, suggesting that CMV infection had caused the bowel hemorrhage. After treatment with ganciclovir, the bleeding was resolved and the CMV antigens became negative. We considered that this patient was further complicated by thrombotic thrombocytopenic purpura (TTP) because of thrombocytopenia, hemolytic anemia and neurologic symptoms. She was treated by plasma exchange. We report here a case of WG complicated by acute intestinal ulcer due to CMV infection and by TTP.
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical University.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Takei
authors.forename: Shigeru
authors.initials: S
authors.lastname: Otsubo
authors.forename: Yuko
authors.initials: Y
authors.lastname: Iwasa
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Yabuki
authors.forename: Keiko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Minako
authors.initials: M
authors.lastname: Koike
authors.forename: Keiko
authors.initials: K
authors.lastname: Uchida
authors.forename: Ken
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Wako
authors.initials: W
authors.lastname: Yumura
authors.forename: Shigeru
authors.initials: S
authors.lastname: Horita
authors.forename: Kazuho
authors.initials: K
authors.lastname: Honda
authors.forename: Takashi
authors.initials: T
authors.lastname: Akiba
authors.forename: Kosaku
authors.initials: K
authors.lastname: Nitta
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000628:therapy; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000628:therapy; D006801:Humans; D007410:Intestinal Diseases / Q000821:virology*; D008875:Middle Aged; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000628:therapy; D014456:Ulcer / Q000628:therapy / Q000821:virology*