Environmental influences on the high mortality from colorectal cancer in African Americans.
Colon cancer is the second leading cause of cancer related death in American adults. The incidence and mortality are highest in African Americans (AAs) (incidence: 52 per 100,000) and lowest in American Hispanics (37 per 100,000). Comparative studies with Native Africans (<5 per 100,000) suggest that genetic susceptibility is an unlikely explanation and that environmental influences are to blame. Studies have suggested that risk is high because of excessive intakes of animal meat and fat products and differences in colonic bacterial metabolism, and that preventative and therapeutic management of colon cancer is compromised by the development of greater tumour virulence possibly resulting from disparities in educational and insurance status, screening behaviour, treatment patterns, social support, and access to and use of health care facilities. It should be possible to reduce the unacceptably higher rates of morbidity and mortality from colon cancer in AAs by dietary and lifestyle changes aimed at suppressing excessive intakes of animal meat and fat products, increasing the consumption of fresh fruit and vegetables, controlling energy balance, and by developing strategies to improve the availability, use and accessibility to health care resources.
Sharma
Sumit
S
Department of Medicine, Rosalind Franklin University of Health and Sciences, Chicago Medical School, Chicago, Illinois, USA.
O'Keefe
Stephen J D
SJ
D001741:Black or African American; D017677:Age Distribution; D015179:Colorectal Neoplasms / Q000208:ethnology / Q000401:mortality*; D003469:Culture; D004032:Diet / Q000009:adverse effects; D004777:Environment; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D012959:Socioeconomic Factors; D014481:United States / Q000453:epidemiology