Hypolipidemic activity of Eclipta prostrata (L.) L. leaf extract in atherogenic diet induced hyperlipidemic rats.
In atherogenic diet induced hyperlipidemic model, the rats receiving treatment with the aqueous extract of the leaves of E. prostrata showed significant reduction in total cholesterol, triglyceride, total protein and elevation in high density lipoprotein cholesterol. The aqueous extract of E. prostrata was found to possess significant hypolipidemic activity. The results also suggest that E. prostrata leaf extract at 100 and 200 mg/kg b.wt. concentrations is an excellent lipid-lowering agent.
Dhandapani
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Medicinal Plants Research Unit, P.G. & Research Department of Microbiology, Thanthai Hans Roever College, Perambalur 621 212, India. paniroever2007@rediffmail.com
D000818:Animals; D050197:Atherosclerosis; D004036:Diet, Atherogenic; D036601:Eclipta / Q000378:metabolism*; D006949:Hyperlipidemias / Q000378:metabolism*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000378:metabolism; D010946:Plants, Medicinal / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism; D014867:Water / Q000378:metabolism