Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFalpha.
Human interleukin-15 (IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic agent. The modulatory effect of TNFalpha was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFalpha was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect by TNFalpha might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting. It is concluded that TNFalpha can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course.
Liu
Xiuping
X
College of Life Science and Technology, Huazhong Universty of Science and Technology, Wuhan 430074, China. Liuxiuping2006@gmail.com
Xiong
Changyun
C
Li
Chunhong
C
Yang
Deguang
D
D017209:Apoptosis / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D019409:Interleukin-15 / Q000037:antagonists & inhibitors*; D009504:Neutrophils / Q000166:cytology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D051020:bcl-X Protein / Q000235:genetics / Q000378:metabolism