title: Oral midazolam for sedation in minor oral operations in children: a retrospective study.
abstract: Our aim was to find out the optimal dose of oral midazolam to sedate children according to age. Thirty-five patients aged 10 or under who had minor oral operations under sedation with midazolam were enrolled. Correlations between age (X) and dose of midazolam (mg/kg; Y) were analysed by Pearson's correlation coefficient, and relations were fitted by simple regression. Doses of midazolam were significantly reduced as age increased (Y=0.969-0.04X; R=0.48) in the satisfactory group (n=25), whereas those in the overdose group (n=10) (patients who vomited, became agitated, or took some time to come round) were significantly higher, decreased with age, and showed a better correlation coefficient (Y=1.375-0.65X; R=0.78). These findings suggest that both the requirement and threshold of midazolam decreases with age.
authors.affiliation: Department of Dental Anesthesiology, Okayama University Hospital of Medicine and Dentistry, Okayama, Japan. atsushik@denta.hal.kagoshima-u.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kohjitani
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Higuchi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Shimada
authors.forename: Takuya
authors.initials: T
authors.lastname: Miyawaki
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D000766:Anesthesia, Dental / Q000379:methods*; D001835:Body Weight; D002648:Child; D016292:Procedural Sedation / Q000379:methods*; D019140:Dental Care for Children; D054796:Drug Dosage Calculations; D062787:Drug Overdose / Q000517:prevention & control; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008874:Midazolam / Q000008:administration & dosage*; D019647:Oral Surgical Procedures; D012044:Regression Analysis; D012189:Retrospective Studies