title: The allosteric modulation of lipases and its possible biological relevance.
abstract: BACKGROUND
  During the development of an enantioselective synthesis using the lipase from Mucor miehei an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown.
  
  
  BACKGROUND
  Considering the biological relevance of the discovered regulation mechanism we developed a theory that describes the regulation of energy homeostasis and fat metabolism.
  
  
  CONCLUSIONS
  This theory represents a new approach to explain the cause of the metabolic syndrome and provides an innovative basis for further research activity.
authors.affiliation: Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Hittorfstrasse 58-62, D-48149 Münster, Germany. jenskoeh@uni-muenster.de
authors.forename: Jens
authors.initials: J
authors.lastname: Köhler
authors.forename: Bernhard
authors.initials: B
authors.lastname: Wünsch
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000494:Allosteric Regulation; D000818:Animals; D016956:Burkholderia cepacia / Q000201:enzymology*; D003198:Computer Simulation; D004734:Energy Metabolism; D006801:Humans; D008049:Lipase / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000145:classification / Q000502:physiology; D024821:Metabolic Syndrome / Q000209:etiology; D009089:Mucor / Q000201:enzymology*; D011487:Protein Conformation; D013559:Symbiosis