Gene therapy for articular cartilage repair.
Articular cartilage serves as the gliding surface of joints. It is susceptible to damage from trauma and from degenerative diseases. Restoration of damaged articular cartilage may be achievable through the use of cell-regulatory molecules that augment the reparative activities of the cells, inhibit the cells' degradative activities, or both. A variety of such molecules have been identified. These include insulin-like growth factor I, fibroblast growth factor 2, bone morphogenetic proteins 2, 4, and 7, and interleukin-1 receptor antagonist. It is now possible to transfer the genes encoding such molecules into articular cartilage and synovial lining cells. Although preliminary, data from in-vitro and in-vivo studies suggest that gene therapy can deliver such potentially therapeutic agents to protect existing cartilage and to build new cartilage.
Trippel
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S
Department of Orthopaedic Surgery, Indiana University School of Medicine, 541 Clinical Drive, Suite 600, Indianapolis, IP 46202-5111, USA. strippel@iupui.edu
Cucchiarini
M
M
Madry
H
H
Shi
S
S
Wang
C
C
D000818:Animals; D002358:Cartilage, Articular / Q000254:growth & development* / Q000293:injuries*; D050724:Fractures, Cartilage / Q000235:genetics* / Q000628:therapy*; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000627:therapeutic use*; D012038:Regeneration / Q000235:genetics*