title: [Effect of IL-4 on ABCG2 expression in human lung adenocarcinoma cell lines].
abstract: OBJECTIVE
  To investigate the effect of IL-4 on the expression of ABCG2 in lung adencarcinoma cell lines.
  
  
  METHODS
  The ABCG2 mRNA and protein expression was determined by semi-quantitative RT-PCR and Western blot respectively.
  
  
  RESULTS
  The ABCG2 mRNA and protein was detectable in lung adencarcinoma cell lines A549 and SPC-A-1. But IL-4 stimulation did not significantly affect the ABCG2 mRNA and protein expression in lung adencarcinoma cell lines.
  
  
  CONCLUSIONS
  IL-4 does not regulate ABCG2 expression in human lung adencarcinoma cell lines.
authors.affiliation: Department of Respiratory Disease, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. zhang72@fmmu.edu.cn
authors.forename: Yu-fei
authors.initials: YF
authors.lastname: Zhang
authors.forename: Hao-wen
authors.initials: HW
authors.lastname: Qi
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Zhao-feng
authors.initials: ZF
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Guo
authors.forename: De-guang
authors.initials: DG
authors.lastname: Mu
authors.forename: Xing-xiang
authors.initials: XX
authors.lastname: Xu
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000378:metabolism*; D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D000818:Animals; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D015847:Interleukin-4 / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism