Naamidines H and I, cytotoxic imidazole alkaloids from the Indonesian marine sponge Leucetta chagosensis.
Two new imidazole alkaloids, naamidines H ( 1) and I ( 2), were isolated from the marine sponge Leucetta chagosensis, collected in North Sulawesi, Indonesia. The compounds ( 1 and 2) showed cytotoxicity against HeLa cells with IC50 values of 5.6 and 15 microg/mL, respectively.
Tsukamoto
Sachiko
S
Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan. sachiko@p.kanazawa-u.ac.jp
Kawabata
Tetsuro
T
Kato
Hikaru
H
Ohta
Tomihisa
T
Rotinsulu
Henki
H
Mangindaan
Remy E P
RE
van Soest
Rob W M
RW
Ukai
Kazuyo
K
Kobayashi
Hisayoshi
H
Namikoshi
Michio
M
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007214:Indonesia; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*