Role of natriuretic peptide signaling in modulating asthma and inflammation.
Atrial natriuretic peptide (ANP), the C-terminal peptide comprising residues 99-126 of the pro-ANP hormone, has been studied for 3 decades for its cardiovascular effects. Recent reports suggest that it plays a significant role in modulation of the immune system. Immune cells, including macrophages, dendritic cells, and T lymphocytes, express receptors for ANP. ANP plays a significant role in shaping the early immune response to environmental antigens and may play a critical role in the interaction between cells of the innate and adaptive immune systems; it also appears to be involved in polarizing the immune response to allergens. Thus, ability to alter the magnitude of natriuretic peptide receptor A (NPRA) signaling could be exploited to develop therapeutics for several allergic diseases, including asthma. This report will review and critically evaluate the role of the ANP pathway in asthma and inflammation.
Mohapatra
Shyam S
SS
Division of Allergy and Immunology-JMC Airway Disease Research Center, Department of Internal Medicine, University of South Florida and VA Hospital, Tampa, FL 33612, USA. smohapat@hsc.usf.edu
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008954:Models, Biological; D011014:Pneumonia / Q000188:drug therapy / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*