title: Naamidines H and I, cytotoxic imidazole alkaloids from the Indonesian marine sponge Leucetta chagosensis.
abstract: Two new imidazole alkaloids, naamidines H ( 1) and I ( 2), were isolated from the marine sponge Leucetta chagosensis, collected in North Sulawesi, Indonesia. The compounds ( 1 and 2) showed cytotoxicity against HeLa cells with IC50 values of 5.6 and 15 microg/mL, respectively.
authors.affiliation: Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan. sachiko@p.kanazawa-u.ac.jp
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kawabata
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kato
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Ohta
authors.forename: Henki
authors.initials: H
authors.lastname: Rotinsulu
authors.forename: Remy E P
authors.initials: RE
authors.lastname: Mangindaan
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Ukai
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Michio
authors.initials: M
authors.lastname: Namikoshi
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007214:Indonesia; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*