title: The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.
abstract: We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.
authors.affiliation: Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
authors.forename: Christina A
authors.initials: CA
authors.lastname: Cuomo
authors.forename: Ulrich
authors.initials: U
authors.lastname: Güldener
authors.forename: Jin-Rong
authors.initials: JR
authors.lastname: Xu
authors.forename: Frances
authors.initials: F
authors.lastname: Trail
authors.forename: B Gillian
authors.initials: BG
authors.lastname: Turgeon
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Pietro
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Walton
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Ma
authors.forename: Scott E
authors.initials: SE
authors.lastname: Baker
authors.forename: Martijn
authors.initials: M
authors.lastname: Rep
authors.forename: Gerhard
authors.initials: G
authors.lastname: Adam
authors.forename: John
authors.initials: J
authors.lastname: Antoniw
authors.forename: Thomas
authors.initials: T
authors.lastname: Baldwin
authors.forename: Sarah
authors.initials: S
authors.lastname: Calvo
authors.forename: Yueh-Long
authors.initials: YL
authors.lastname: Chang
authors.forename: David
authors.initials: D
authors.lastname: Decaprio
authors.forename: Liane R
authors.initials: LR
authors.lastname: Gale
authors.forename: Sante
authors.initials: S
authors.lastname: Gnerre
authors.forename: Rubella S
authors.initials: RS
authors.lastname: Goswami
authors.forename: Kim
authors.initials: K
authors.lastname: Hammond-Kosack
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Harris
authors.forename: Karen
authors.initials: K
authors.lastname: Hilburn
authors.forename: John C
authors.initials: JC
authors.lastname: Kennell
authors.forename: Scott
authors.initials: S
authors.lastname: Kroken
authors.forename: Jon K
authors.initials: JK
authors.lastname: Magnuson
authors.forename: Gertrud
authors.initials: G
authors.lastname: Mannhaupt
authors.forename: Evan
authors.initials: E
authors.lastname: Mauceli
authors.forename: Hans-Werner
authors.initials: HW
authors.lastname: Mewes
authors.forename: Rudolf
authors.initials: R
authors.lastname: Mitterbauer
authors.forename: Gary
authors.initials: G
authors.lastname: Muehlbauer
authors.forename: Martin
authors.initials: M
authors.lastname: Münsterkötter
authors.forename: David
authors.initials: D
authors.lastname: Nelson
authors.forename: Kerry
authors.initials: K
authors.lastname: O'donnell
authors.forename: Thérèse
authors.initials: T
authors.lastname: Ouellet
authors.forename: Weihong
authors.initials: W
authors.lastname: Qi
authors.forename: Hadi
authors.initials: H
authors.lastname: Quesneville
authors.forename: M Isabel G
authors.initials: MI
authors.lastname: Roncero
authors.forename: Kye-Yong
authors.initials: KY
authors.lastname: Seong
authors.forename: Igor V
authors.initials: IV
authors.lastname: Tetko
authors.forename: Martin
authors.initials: M
authors.lastname: Urban
authors.forename: Cees
authors.initials: C
authors.lastname: Waalwijk
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Ward
authors.forename: Jiqiang
authors.initials: J
authors.lastname: Yao
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Birren
authors.forename: H Corby
authors.initials: HC
authors.lastname: Kistler
mesh_terms: D004271:DNA, Fungal; D019143:Evolution, Molecular; D005670:Fusarium / Q000235:genetics* / Q000502:physiology; D016681:Genome, Fungal; D001467:Hordeum / Q000382:microbiology; D008969:Molecular Sequence Data; D010935:Plant Diseases / Q000382:microbiology; D017354:Point Mutation; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA