Juvenile hormone activity of ethyl 4-(2-aryloxyhexyloxy)benzoates with precocious metamorphosis-inducing activity.
Ethyl 4-[2-(6-methyl-3-pyridyloxy)hexyloxy]benzoate (1) and ethyl 4-(2-phenoxyhexyloxy)benzoate (2), which induce precocious metamorphosis in larvae of Bombyx mori, a clear sign of juvenile hormone (JH) deficiency, showed JH activity when topically applied to allatectomized 4th instar larvae of B. mori. Compounds 1 and 2 induced precocious metamorphosis with doses at which they were effective as JH agonists.
Fujita
Norihiro
N
Laboratory of Pesticide Chemistry, Department of Applied Genetics and Pest Management, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
Ashibe
Kiyo
K
Yamada
Naotaka
N
Shiotsuki
Takahiro
T
Kiuchi
Makoto
M
Kuwano
Eiichi
E
D000818:Animals; D019817:Benzoic Acid / Q000737:chemistry* / Q000494:pharmacology*; D012831:Bombyx / Q000187:drug effects* / Q000254:growth & development*; D007605:Juvenile Hormones / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D008675:Metamorphosis, Biological / Q000187:drug effects*; D015394:Molecular Structure