Mechanism and significance of early, rapid shortening in sensitized airway smooth muscle.
It has been reported that sensitization of animals to allergens increases both early shortening velocity and myosin light-chain kinase of their airway smooth muscle without increasing force generated by these muscles. Since early shortening sets muscle length for the duration of a contraction, these responses might be expected to produce greater airway obstruction. Here, it is explained how the more rapid early shortening without increased force production is predicted by the 2-stage process of activation followed by contraction posited by the crossbridge theory of contraction when the rate, but not the extent, of activation is increased. The experimental results are reproduced by a simple model in which activation rate is increased 1.6-fold without any other changes in contractile parameters. These results reinforce suggestions that sensitized animals are a model for reactive airway disease.
Ford
Lincoln E
LE
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. lieford@iupui.edu
Gilbert
Susan H
SH
D000402:Airway Obstruction / Q000503:physiopathology; D000465:Algorithms; D000818:Animals; D001249:Asthma / Q000503:physiopathology; D001696:Biomechanical Phenomena; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D003198:Computer Simulation; D004285:Dogs; D007114:Immunization; D008954:Models, Biological; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology / Q000503:physiopathology*; D012756:Sheep; D014132:Trachea / Q000502:physiology / Q000503:physiopathology