title: Gefitinib-induced pneumonitis in non-small cell lung cancer: radiological and clinical findings in five patients.
abstract: OBJECTIVE
  The objective of this study was to describe the radiological and clinical features of gefitinib-induced pneumonitis in non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Five patients who suffered dyspnea after gefitinib treatment were selected. Chest radiographs and computed tomography (CT) findings, along with clinical course, were evaluated.
  
  
  RESULTS
  Patients complained of subacute dyspnea and hypoxia. Three patients improved after discontinuation of gefitinib, while remaining two showed no response. Unilateral or bilateral ground glass opacity was observed on chest radiographs and CT.
  
  
  CONCLUSIONS
  Radiological findings of gefitinib-induced pneumonitis were nonspecific, but radiologists should be aware of this adverse reaction, which can appear during the treatment in NSCLC patients.
authors.affiliation: Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, South Korea.
authors.forename: Hee Sun
authors.initials: HS
authors.lastname: Park
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jung-Gi
authors.initials: JG
authors.lastname: Im
authors.forename: Jin Mo
authors.initials: JM
authors.lastname: Goo
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Lee
authors.forename: Chang Min
authors.initials: CM
authors.lastname: Park
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Chun
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D011799:Quinazolines / Q000009:adverse effects* / Q000627:therapeutic use*; D011859:Radiography