Fatal malignant melanoma in a child with neurofibromatosis type 1.
Neurofibromatosis type 1 is an autosomal dominant disease and is considered one of the most commonly inherited diseases in humans. Malignant melanoma has been reported in up to 5% of patients with neurofibromatosis type 1. We report a young Saudi boy with neurofibromatosis type 1 who developed fatal metastatic malignant melanoma arising from giant melanocytic nevi within speckled lentiginous nevus (SLN).
Bin Amer
Yousef
Y
Division of Dermatology, Department of Medicine, King Fahad National Guard Hospital, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.
Al-Khenaizan
Sultan
S
D001859:Bone Neoplasms / Q000150:complications / Q000473:pathology / Q000556:secondary*; D002471:Cell Transformation, Neoplastic; D017809:Fatal Outcome; D005269:Femur / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D008545:Melanoma / Q000150:complications / Q000473:pathology / Q000556:secondary*; D009456:Neurofibromatosis 1 / Q000150:complications*; D009508:Nevus, Pigmented / Q000150:complications / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*