5'-halogenated analogs of oxymorphindole.
The presence of a 6,7-fused indole group in the indolomorphinans was considered to be responsible for the delta opioid selectivity for this class of ligands. Herein is shown that 5'-halogenated analogs of oxymorphindole are opioids with little selectivity for delta receptors over mu opioid receptors.
Metcalf
Matthew D
MD
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA.
Coop
Andrew
A
D006219:Halogens / Q000737:chemistry*; D009025:Morpholines / Q000737:chemistry* / Q000494:pharmacology; D017465:Receptors, Opioid, delta / Q000187:drug effects; D017450:Receptors, Opioid, mu / Q000187:drug effects