Bone mass in elderly patients with Parkinson's disease.
OBJECTIVE
The objective of the present study was to find risk factors for low bone mineral density (BMD) in patients with Parkinson's disease (PD).


METHODS
Twenty-six PD patients and 26 age-and sex-matched healthy controls were assessed twice within a 1-year period. PD symptoms, body weight, body fat mass, BMD, physical activity, smoking and serum concentrations of several laboratory analyses were investigated.


RESULTS
BMD in different locations was lower in PD patients compared with their controls and decreased during the investigated year. BMD was lower in PD patients with low body weight. BMD Z-score of trochanter in the PD group was directly correlated to the degree of physical activity and indirectly to the length of recumbent rest. Total body BMD Z-score in the PD group was directly correlated to the degree of rigidity. Serum 25-hydroxy-vitamin D was slightly lower in PD patients.


CONCLUSIONS
Low body weight and low physical activity were risk factors for low BMD in PD, while rigidity seemed to be protective.
Lorefält
B
B
Department of Medicine and Care, Linköping University, Sweden. birgitta.lorefalt@imv.liu.se
Toss
G
G
Granérus
A-K
AK
D000368:Aged; D001827:Body Height; D001835:Body Weight; D015519:Bone Density; D016022:Case-Control Studies; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*