title: Phosphor/sulphur ratio: an indicator of malignant uterus change.
abstract: The purpose of the present study was to establish a correlation between gynaecological diseases (myoma, adenocarcinoma) and phosphor/sulphur (P/S) ratios of different regions of the uterus. Routine histological specimens were reexamined with the intention to select representative regions of the uteruses for element analysis. Conventional hematoxylin-eosin-stained sections were used to identify histological alterations by light microscopy. Scanning electron microscopic (SEM) and energy-dispersive spectroscopic (EDS) investigations were carried out to analyze the morphology and the related element composition of the samples. The results of the nonparametric statistical test (Wilcoxon rank-sum test) indicate that the P/S ratios were significantly higher in adenocarcinoma (0.8891 +/- 0.0757) than in myoma (0.4713 +/- 0.0306). P/S ratios of different pathologic regions of uteruses seem worth examining in a larger study population. Combination of routine histological examinations with element analysis of specimens may have useful applications in patients who have undergone radiation therapy and may identify a pattern for local recurrence at certain sites.
authors.affiliation: Second Department of Obstetrics and Gynaecology, Semmelweis University, 78/a Ullöi Street, H-1082 Budapest, Hungary.
authors.forename: Kálmán
authors.initials: K
authors.lastname: Patai
authors.forename: László
authors.initials: L
authors.lastname: Dévényi
authors.forename: Márta
authors.initials: M
authors.lastname: Hubay
authors.forename: Sándor
authors.initials: S
authors.lastname: Csömör
authors.forename: Romána
authors.initials: R
authors.lastname: Zelkó
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D010713:Phosphatidylcholines / Q000378:metabolism; D010758:Phosphorus / Q000032:analysis*; D013052:Spectrometry, X-Ray Emission; D013455:Sulfur / Q000032:analysis*; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D014599:Uterus / Q000378:metabolism / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure