Estimation of true incidence of polio: overcoming misclassification errors due to stool culture insensitivity.
The diagnosis of polio dependents on culturing the virus in stool samples of children with AFP. Using data obtained under the "Right to Information Act" of instances where only one of the two samples was positive for polio, it was possible to estimate the sensitivity of the system to detect cases of polio. The calculations suggest that there were 1625 (95% CI 1528 to 1725) cases of polio in India in 2006 rather than the 674 reported widely!
Srinivas
V
V
Department of Biostatistics, All India Institute of Medical Science, New Delhi;110 029, India.
Puliyel
Jacob M
JM
D005188:False Negative Reactions; D005243:Feces / Q000821:virology*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D011051:Poliomyelitis / Q000175:diagnosis* / Q000453:epidemiology*; D012680:Sensitivity and Specificity