title: "Atmospheric" Epoxidation of Benzo[a]pyrene by Ozone: Formation of the Metabolite Benzo[a]pyrene-4,5-Oxide.
abstract: Benzo[a]pyrene deposited on a glass fiber filter reacts rapidly in the dark or light with ambient levels of ozone to yield a mixture of products that display strong direct mutagenicity in the Ames assay. The major stable contributor to this activity has been identified as benzo[a]pyrene-4,5-oxide, a DNA-binding metabolite in biological systems, known to be a strong direct mutagen with Salmonella typhimurium strain TA98.
authors.forename: J N
authors.initials: JN
authors.lastname: Pitts
authors.forename: D M
authors.initials: DM
authors.lastname: Lokensgard
authors.forename: P S
authors.initials: PS
authors.lastname: Ripley
authors.forename: K A
authors.initials: KA
authors.lastname: VAN Cauwenberghe
authors.forename: L
authors.initials: L
authors.lastname: VAN Vaeck
authors.forename: S D
authors.initials: SD
authors.lastname: Shaffer
authors.forename: A J
authors.initials: AJ
authors.lastname: Thill
authors.forename: W L
authors.initials: WL
authors.lastname: Belser