title: Anti-tumour necrosis factor-alpha therapy for severe enteropathy in patients with common variable immunodeficiency (CVID).
abstract: We present three common variable immunodeficiency (CVID) patients with severe inflammatory bowel disease of unknown aetiology, resistant to steroid treatment, treated with infliximab. After exclusion of any infection, infliximab was given at a dose of 5 mg/kg every 4 weeks for a 3 month induction followed by every 4-8 weeks depending on clinical response. Two of these patients had predominantly small bowel disease; they both showed clinical response to infliximab with weight gain and improvement of quality of life scores. The third patient had large bowel involvement with profuse watery diarrhea; this patient improved dramatically within 48 hours of having infliximab treatment. All three patients have been maintained on infliximab treatment for between 5 and 53 months (mean 37 months) with no evidence of increased susceptibility to infections in the patients with small bowel disease, although the third patient developed two urinary tract infections and a herpes zoster infection following therapy. This is the first small case series to show that infliximab is a useful addition to current therapy in this rare group of patients with potentially life threatening enteritis.
authors.affiliation: Department of Immunology, Royal Free Hospital Hampstead, London, UK. cichua@hotmail.com
authors.forename: I
authors.initials: I
authors.lastname: Chua
authors.forename: R
authors.initials: R
authors.lastname: Standish
authors.forename: S
authors.initials: S
authors.lastname: Lear
authors.forename: M
authors.initials: M
authors.lastname: Harbord
authors.forename: E
authors.initials: E
authors.lastname: Eren
authors.forename: M
authors.initials: M
authors.lastname: Raeiszadeh
authors.forename: S
authors.initials: S
authors.lastname: Workman
authors.forename: D
authors.initials: D
authors.lastname: Webster
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003106:Colon / Q000473:pathology; D017074:Common Variable Immunodeficiency / Q000150:complications*; D004386:Duodenum / Q000473:pathology; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*