title: (1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.
abstract: Synthesis, pharmacology, and pharmacokinetic profiles of (1R, 2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile are reported. This compound demonstrated remarkable potency for stimulating hair growth in a male C3H mouse model as well as reducing sebum production in the male Syrian hamster ear model.
authors.affiliation: Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. lain-yen.hu@pfizer.com
authors.forename: Lain-Yen
authors.initials: LY
authors.lastname: Hu
authors.forename: Daniel
authors.initials: D
authors.lastname: Du
authors.forename: Jennifer
authors.initials: J
authors.lastname: Hoffman
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Smith
authors.forename: Victor
authors.initials: V
authors.lastname: Fedij
authors.forename: Catherine
authors.initials: C
authors.lastname: Kostlan
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Johnson
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
authors.forename: Steve
authors.initials: S
authors.lastname: Kesten
authors.forename: William
authors.initials: W
authors.lastname: Harter
authors.forename: Wen Song
authors.initials: WS
authors.lastname: Yue
authors.forename: Jie Jack
authors.initials: JJ
authors.lastname: Li
authors.forename: Nicole
authors.initials: N
authors.lastname: Barvian
authors.forename: Lorna
authors.initials: L
authors.lastname: Mitchell
authors.forename: Huangshu John
authors.initials: HJ
authors.lastname: Lei
authors.forename: Bruce
authors.initials: B
authors.lastname: Lefker
authors.forename: Mathew
authors.initials: M
authors.lastname: Carroll
authors.forename: Danielle
authors.initials: D
authors.lastname: Dettling
authors.forename: Teresa
authors.initials: T
authors.lastname: Krieger-Burke
authors.forename: Brian
authors.initials: B
authors.lastname: Samas
authors.forename: Radhika
authors.initials: R
authors.lastname: Yalamanchili
authors.forename: Kimberly
authors.initials: K
authors.lastname: Lapham
authors.forename: David
authors.initials: D
authors.lastname: Pocalyko
authors.forename: Drago
authors.initials: D
authors.lastname: Sliskovic
authors.forename: Susan
authors.initials: S
authors.lastname: Ciotti
authors.forename: Brenda
authors.initials: B
authors.lastname: Stoller
authors.forename: Mostofa A
authors.initials: MA
authors.lastname: Hena
authors.forename: Qizhu
authors.initials: Q
authors.lastname: Ding
authors.forename: Samarendra N
authors.initials: SN
authors.lastname: Maiti
authors.forename: Michael
authors.initials: M
authors.lastname: Stier
authors.forename: Howard
authors.initials: H
authors.lastname: Welgus
mesh_terms: D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D006197:Hair / Q000254:growth & development*; D006845:Hydrocarbons, Fluorinated / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008958:Models, Molecular; D009570:Nitriles / Q000493:pharmacokinetics / Q000494:pharmacology*; D012629:Sebum