Nanoparticles for drug delivery: the need for precision in reporting particle size parameters.
Polymeric drug-loaded nanoparticles have been extensively studied in the field of drug delivery. Biodistribution depends on the physicochemical properties of particles, especially size. The global message from the literature is that small particles have an enhanced ability to reach their target. The present review highlights the difficulties in validating the data from biodistribution studies without accurate particle size determination.
Gaumet
Marie
M
Department of Pharmaceutics and Biopharmaceutics, University of Geneva, University of Lausanne, Geneva, Switzerland.
Vargas
Angelica
A
Gurny
Robert
R
Delie
Florence
F
D000818:Animals; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004345:Drug Industry / Q000639:trends; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical