title: Primary intracranial squamous cell carcinoma arising in an epidermoid cyst--a case report and review of literature.
abstract: Primary intracranial squamous cell carcinoma is extremely rare, with most of the cases arising from malignant transformation of an epidermoid or a dermoid cyst. We report here a case of a 45-year-old male patient who presented with 1-month history of intermittent headache and recent onset of altered sensorium. Imaging revealed a midline posterior fossa mass lesion compressing the fourth ventricle and causing hydrocephalus. A provisional diagnosis of dermoid cyst was considered. Histopathological examination revealed a squamous cell carcinoma possibly arising from an underlying epidermoid cyst. This entity is being reported for its rarity.
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Shipra
authors.initials: S
authors.lastname: Agarwal
authors.forename: Arvind
authors.initials: A
authors.lastname: Rishi
authors.forename: Vaishali
authors.initials: V
authors.lastname: Suri
authors.forename: M C
authors.initials: MC
authors.lastname: Sharma
authors.forename: G D
authors.initials: GD
authors.lastname: Satyarthi
authors.forename: Ajay
authors.initials: A
authors.lastname: Garg
authors.forename: Chitra
authors.initials: C
authors.lastname: Sarkar
mesh_terms: D001927:Brain Diseases / Q000473:pathology / Q000601:surgery*; D002114:Calcinosis / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002784:Cholesterol / Q000032:analysis; D003388:Cranial Fossa, Posterior / Q000473:pathology / Q000601:surgery*; D003937:Diagnosis, Differential; D004814:Epidermal Cyst / Q000473:pathology / Q000601:surgery*; D020546:Fourth Ventricle / Q000473:pathology; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D019292:Skull Base Neoplasms / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed