[Consequences of stimulation on oocyte quality].
In all IVF programs, ovarian stimulation may lead to a hyperstimulation syndrome. Mild ovarian stimulations are suggested to reduce this complication of infertility treatment. In this article, we wonder what the consequences of different stimulations are on oocytes quality. The quality of the oocyte being the major factor of the development of a good embryo, it can be evaluated by direct or indirect techniques. Some are subjective. Several studies seem to show that ovarian stimulation has an influence on oocye quality, especially at a chromosomic and perharps, epigenetic level. It seems that a mild stimulation (for example with GnRH antagonist) selects less oocytes but with a better quality and produces euploid embryos. The uterine transfer of this kind of embryo should lead to an ongoing pregnancy.
Clément
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Unité de génétique et reproduction, laboratoire Clément, 8, avenue Henri-Barbusse, 93150 Le-Blanc-Mesnil, France. clementpat@wanadoo.fr
D002877:Chromosomes, Human; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D009865:Oocytes / Q000166:cytology / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods*