Biology of dendritic cells in aging.
Dendritic cells are central to the generation of both immunity and tolerance. This review focuses on the alterations in the functions of dendritic cells in aged and its consequences on both tolerance and immunity. We have discussed certain mechanisms responsible for the defective dendritic cell function associated with aging.
Agrawal
Anshu
A
Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA. aagrawal@uci.edu
Agrawal
Sudhanshu
S
Tay
Jia
J
Gupta
Sudhir
S
D000375:Aging / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000276:immunology; D016922:Cellular Senescence / Q000276:immunology*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D007113:Immunity, Innate; D011494:Protein Kinases / Q000378:metabolism