The effect of divalproex sodium on HIV replication in vivo.
In vitro data suggest valproate activates HIV replication. This study prospectively assesses whether divalproex sodium causes an increase in HIV replication in patients. Eight participants had their HIV viral load measured over approximately 1 month. The largest increases in viral load occurred in patients without antiretroviral medication. No patients had an increase in Log10 HIV viral load > or = 0.5. Further study is needed to understand implications.
Maggi
Julie D
JD
St. Michael's Hospital, Mental Health Service, and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. maggij@smh.toronto.on.ca
Halman
Mark H
MH
D000328:Adult; D018791:CD4 Lymphocyte Count; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D014635:Valproic Acid / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects*