title: Monooxygenase Induction and Chlorobiphenyls in the Deep-Sea Fish Coryphaenoides armatus.
abstract: Inhibition of liver microsomal ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase activities by alpha-naphthoflavone and by polyclonal antibodies to hydrocarbon-inducible cytochrome P-450E from teleost liver indicated a xenobiotic-induced origin of these activities in the deep-sea fish Coryphaenoides armatus. Specific recognition of a protein by antibodies to P-450E in an immunoblot assay further indicated xenobiotic-induced cytochrome P-450 in these animals. Levels of apparently induced cytochrome P-450 and monooxygenase activity correlated positively with the tissue content of chlorobiphenyls of known inducing activity, implicating such compounds in biochemical effects occurring in the deep ocean.
authors.forename: J J
authors.initials: JJ
authors.lastname: Stegeman
authors.forename: P J
authors.initials: PJ
authors.lastname: Kloepper-Sams
authors.forename: J W
authors.initials: JW
authors.lastname: Farrington