title: Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
abstract: OBJECTIVE
  Can monovoxel magnetic resonance spectroscopy (MRS) reliably follow tumour progression in low-grade glioma?
  
  
  METHODS
  21 patients with low-grade glioma underwent at least 3 MRS.
  
  
  RESULTS
  For progression from a grade II to grade III tumour, a sensitivity of 57.1% and specificity of 60% were observed, with a positive predictive value (PPV) of 48.8% and a negative predictive value (NPV) of 54.5%. For progression under treatment, we obtained a sensitivity of 57.1% by N-acetylaspartate (NAA)/choline (Cho) and myoinositol/creatine (Cr) and a specificity of 100% by Cho/Cr and lipids, with a PPV of 80% and a NPV of 63.6%.
  
  
  CONCLUSIONS
  We found that NAA/Cho is the best marker of tumour progression before therapy, with a sensitivity of 53.9%. For the therapeutic response, sensitivity was only 28.2%.
authors.affiliation: Department of Radiology, Geneva University Hospital, Geneva, Switzerland.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Alimenti
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Delavelle
authors.forename: François
authors.initials: F
authors.lastname: Lazeyras
authors.forename: Hasan
authors.initials: H
authors.lastname: Yilmaz
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Dietrich
authors.forename: Nicolas
authors.initials: N
authors.lastname: de Tribolet
authors.forename: Karl-Olof
authors.initials: KO
authors.lastname: Lövblad
mesh_terms: D000328:Adult; D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D007294:Inositol / Q000378:metabolism; D008137:Longitudinal Studies; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011522:Protons; D012189:Retrospective Studies