Evidence of slow maturation of the superior longitudinal fasciculus in early childhood by diffusion tensor imaging.
While the majority of axonal organization is established by birth in mammalian brains, axonal wiring and pruning processes, as well as myelination, are known to extend to the postnatal periods, where environmental stimuli often play a major role. Normal axonal and myelin development of individual white matter tracts of human in this period is poorly understood and may have a major role in cognitive development of human. In this study, we applied diffusion tensor imaging and normalization-based population analyses to 44 preteen children and 30 adult images. We observed highly significant changes of fiber orientations at regions that correspond to the superior longitudinal fasciculus during the first 5 years. The result is attributed to slow axonal and/or myelin maturation of this tract, which is believed to be involved in language functions.
Zhang
Jiangyang
J
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA, and Diagnostic Radiology Unit, Saint-Luc University Hospital, Brussels, Belgium.
Evans
Alan
A
Hermoye
Laurent
L
Lee
Seung-Koo
SK
Wakana
Setsu
S
Zhang
Weihong
W
Donohue
Pamela
P
Miller
Michael I
MI
Huang
Hao
H
Wang
Xiaoqing
X
van Zijl
Peter C M
PC
Mori
Susumu
S
D000328:Adult; D000375:Aging / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology*; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development*; D001931:Brain Mapping / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn