Long-term outcome of 50 consecutive Parkinson's disease patients treated with subthalamic deep brain stimulation.
OBJECTIVE
To describe the long-term outcome in 50 consecutive advanced Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS).


METHODS
Assessments were carried out at baseline, 6 months, 2 years, and 5 years postoperatively.


RESULTS
Compared to baseline scores without medication, we found a highly significant improvement of UPDRS III with stimulation, maintained at 5 years (p<0.001). This improvement, however, tended to diminish over time. Dyskinesia and off periods were also improved (p<0.0001 for both). Seventeen patients died during follow-up, who tended to be older at surgery (p<0.01).


CONCLUSIONS
STN-DBS is an effective treatment for advanced PD patients, and the beneficial effect is maintained at 5 years. However, worsening occurs over time due to disease progression.
Wider
C
C
Department of Neurology, CHUV, Rue du Bugnon, 1011 Lausanne, Switzerland.
Pollo
C
C
Bloch
J
J
Burkhard
P R
PR
Vingerhoets
F J G
FJ
D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D015331:Cohort Studies; D046690:Deep Brain Stimulation / Q000009:adverse effects; D004567:Electrodes, Implanted; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008839:Microelectrodes; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D010300:Parkinson Disease / Q000401:mortality / Q000628:therapy*; D011446:Prospective Studies; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus; D016019:Survival Analysis; D016896:Treatment Outcome