Differences in developing intestinal microbiota between allergic and non-allergic infants: a pilot study in Japan.
The bacterial compositions of feces were monitored in the first 2 months for 15 infants born in Japan, including eight subjects who developed allergy by the age of 2 years. Primer sets targeting six predominant bacterial groups in the infant intestine, Bacteroidaceae, Enterobacteriaceae, bifidobacteria, enterococci, lactobacilli, and the Clostridium perfringens group, were used for real-time PCR to quantitate each population in the feces. The population of Bacteroidaceae was significantly higher in the allergic group at the ages of 1 month (P=0.03) and 2 months (P=0.05) than in the non-allergic group, while no statistically significant difference was observed for the other bacterial populations.
Songjinda
Prapa
P
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
Nakayama
Jiro
J
Tateyama
Atsushi
A
Tanaka
Shigemitsu
S
Tsubouchi
Mina
M
Kiyohara
Chikako
C
Shirakawa
Taro
T
Sonomoto
Kenji
K
D006801:Humans; D006967:Hypersensitivity / Q000382:microbiology*; D007223:Infant; D007422:Intestines / Q000382:microbiology*; D010865:Pilot Projects; D012336:RNA, Ribosomal, 16S / Q000235:genetics