The role of autocrine motility factor in tumor and tumor microenvironment.
Autocrine motility factor (AMF) is a tumor-secreted cytokine and is abundant at tumor sites, where it may affect the process of tumor growth and metastasis. AMF is a multifunctional protein capable of affecting cell migration, invasion, proliferation, and survival, and possesses phosphoglucose isomerase activity and can catalyze the step in glycolysis and gluconeogenesis. Here, we review the role of AMF and tumor environment on malignant processes. The outcome of metastasis depends on multiple interactions between tumor cells and homeostatic mechanisms, therefore elucidation of the tumor/host interactions in the tumor microenvironment is essential in the development of new prevention and treatment strategies. Such knowledge might provide clues to develop new future therapeutic approaches for human cancers.
Funasaka
Tatsuyoshi
T
Tumor Progression and Metastasis Program, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Raz
Avraham
A
D015687:Cell Hypoxia; D018450:Disease Progression; D005956:Glucose-6-Phosphate Isomerase / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000209:etiology*; D009389:Neovascularization, Pathologic / Q000209:etiology; D060285:Receptors, Autocrine Motility Factor; D018121:Receptors, Cytokine / Q000502:physiology; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology