Clinical applications of rhBMP-2 in maxillofacial surgery.
METHODS
Examples of defects including mandibular continuity defects, preprosthetic atrophic alveolar ridge deficiencies, traumatic defects, and maxillary clefts were included.


RESULTS
All patients demonstrated osseous regeneration stimulated by rhBMP-2.


CONCLUSIONS
rhBMP-2 is successful in regenerating bone in a variety of maxillofacial defects. In the future, rhBMP-2 will play a significant role in the treatment of bone deficiencies.
Herford
Alan S
AS
Department of Oral and Maxillofacial Surgery, Loma Linda University School of Dentistry, Loma Linda, CA 92350, USA.
Boyne
Philip J
PJ
Williams
Roland P
RP
D000293:Adolescent; D000540:Alveolar Ridge Augmentation / Q000379:methods; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation / Q000379:methods; D002648:Child; D002972:Cleft Palate / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000601:surgery; D008437:Maxilla / Q000601:surgery; D008446:Maxillofacial Injuries / Q000601:surgery; D008875:Middle Aged; D019647:Oral Surgical Procedures; D011994:Recombinant Proteins / Q000627:therapeutic use*; D019651:Plastic Surgery Procedures; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D014948:Wounds, Gunshot / Q000601:surgery