title: PTEN: its deregulation and tumorigenesis.
abstract: The tumor suppressor phosphatase and tensin homolog (PTEN) functions as a phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and negatively regulates cell proliferation and survival signals. Inactivation of PTEN by loss-of-function mutations gives rise to deregulated hyperproliferation of cells, leading to oncogenic transformation. Recent studies have identified a number of upstream regulatory factors for PTEN and unveiled that the impairment in the PTEN regulatory system potentially becomes a causal factor for oncogenic transformation of cells. This article will review the PTEN inactivation mechanism which is linked to human tumorigenesis, particularly focusing on recent research progress in PTEN regulators.
authors.affiliation: Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan. tmaehama@nih.go.jp
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Maehama
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D006801:Humans; D009154:Mutation / Q000502:physiology; D009369:Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000081082:Phosphoinositide-3 Kinase Inhibitors