title: N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease.
abstract: A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related sugar hydrolases enzymes are described.
authors.affiliation: NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892-3370, USA.
authors.forename: Wenwei
authors.initials: W
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Urban
authors.forename: James
authors.initials: J
authors.lastname: Inglese
authors.forename: Ellen
authors.initials: E
authors.lastname: Sidransky
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Austin
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Thomas
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D005776:Gaucher Disease / Q000201:enzymology*; D005962:Glucosylceramidase / Q000037:antagonists & inhibitors*; D006801:Humans; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology*