The proinflammatory cytokines TNF-alpha and IL-1 beta impair economy of contraction in human myocardium.
Considerable experimental evidence has accumulated over the past years that proinflammatory cytokines, especially TNF-alpha and IL-1beta, impair myocardial function in different animal species. On the other hand, several prospective clinical trials studying TNF-alpha antagonist in patients with chronic heart failure were not able to demonstrate a benefit. As there might be a relevant species-related discrepancy, we intended to prove our previous results demonstrating impaired myocardial economy after exogenous administration of recombinant TNF-alpha in rat myocardium. In the present study, both TNF-alpha and IL-1beta not only revealed an immediate negative inotropic effect but also increased specific oxygen demand in human right-atrial myocardium. Enhanced oxygen consumption was not caused by an elevated basal metabolism but an impaired economy of contraction. Our results suggest that proinflammatory cytokines have a considerable effect on myocardial mechano-energetic parameters in human myocardium as well.
Hofmann
U
U
University of Wurzburg, Medizinische Klinik und Poliklinik I, Abteilung Kardiologie, Germany. hofmann_u2@klinik.uni-wuerzburg.de
Heuer
S
S
Meder
K
K
Boehler
J
J
Lange
V
V
Quaschning
T
T
Ertl
G
G
Bonz
A
A
D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000494:pharmacology*; D053583:Interleukin-1beta / Q000494:pharmacology*; D007537:Isometric Contraction / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000276:immunology; D009206:Myocardium / Q000276:immunology / Q000378:metabolism*; D010101:Oxygen Consumption / Q000276:immunology; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*