title: Misdiagnosis of hydrophilic acrylic intraocular lens optic opacification: report of 8 cases with the MemoryLens.
abstract: OBJECTIVE
  To report 8 patients with misdiagnosis of MemoryLens intraocular lens (IOL) late postoperative calcification and the resulting potentially avoidable procedures leading to secondary complications.
  
  
  METHODS
  Retrospective interventional case series.
  
  
  METHODS
  Eight patients with an opacified hydrophilic acrylic MemoryLens.
  
  
  METHODS
  Eight cases of MemoryLens IOL opacification that were originally misdiagnosed were reviewed. The following parameters were noted: baseline patient characteristics, time frame of IOL opacification, original misdiagnosis, subsequent surgical procedures, and postexplantation outcomes and complications. Two explanted lenses from this series were available for laboratory analyses. They underwent gross and light microscopic evaluation and scanning electron microscopy with energy-dispersive x-ray spectroscopy (EDS).
  
  
  METHODS
  Patient parameters noted above. The IOLs were examined for distribution, structure, and composition of the deposits causing opacification of their optic components.
  
  
  RESULTS
  All 8 patients' IOLs were implanted between August 1999 and March 2000. Complaints of decreased visual function occurred 13 to 58 months after implantation. Half of the patients were initially diagnosed as having posterior capsular opacification and underwent neodymium:yttrium-aluminum-garnet laser capsulotomy. The other half were initially diagnosed with some form of vitreous involvement and underwent vitrectomies. Six of the 8 patients underwent subsequent lens exchanges, with 3 of them having postexchange complications including endophthalmitis, cystoid macular edema, and retinal detachment. Scanning electron microscopy with EDS confirmed the presence of calcified deposits on the surface of the 2 explants available for analysis. The deposits also stained positive for calcium.
  
  
  CONCLUSIONS
  Despite previous reports, misdiagnosis of MemoryLens IOL calcification leading to optic opacification still occurs. Not recognizing this process can lead to potentially avoidable surgical procedures and increased risk of complications after repeated interventions.
authors.affiliation: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Haymore
authors.forename: Gerald
authors.initials: G
authors.lastname: Zaidman
authors.forename: Liliana
authors.initials: L
authors.lastname: Werner
authors.forename: Nick
authors.initials: N
authors.lastname: Mamalis
authors.forename: Stephan
authors.initials: S
authors.lastname: Hamilton
authors.forename: James
authors.initials: J
authors.lastname: Cook
authors.forename: Thomas
authors.initials: T
authors.lastname: Gillette
mesh_terms: D000180:Acrylic Resins; D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000175:diagnosis*; D002118:Calcium / Q000032:analysis; D002386:Cataract / Q000175:diagnosis*; D020878:Device Removal; D003951:Diagnostic Errors; D004577:Electron Probe Microanalysis; D005260:Female; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D018918:Phacoemulsification; D011183:Postoperative Complications; D012086:Reoperation; D012189:Retrospective Studies