title: Combined effect of the essential oil from Chenopodium ambrosioides and antileishmanial drugs on promastigotes of Leishmania amazonensis.
abstract: To date, there are no vaccines against Leishmania, and chemotherapy remains the mainstay for the control of leishmaniasis. The drugs of choice used for leishmaniasis therapy are significantly toxic, expensive and with a growing frequency of refractory infections. Because of these limitations, a combination therapy is the better hope. This work demonstrates that the essential oil from Chenopodium ambrosioides shows a synergic activity after incubation in conjunction with pentamidine against promastigotes of Leishmania amazonensis. However, an indifferent effect has been found for combinations of meglumine antimoniate or amphotericin B and the essential oil.
authors.affiliation: Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Ciudad de la Habana, Cuba. monzote@ipk.sld.cu
authors.forename: Lianet
authors.initials: L
authors.lastname: Monzote
authors.forename: Ana Margarita
authors.initials: AM
authors.lastname: Montalvo
authors.forename: Ramón
authors.initials: R
authors.lastname: Scull
authors.forename: Migdalia
authors.initials: M
authors.lastname: Miranda
authors.forename: Juan
authors.initials: J
authors.lastname: Abreu
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D027464:Chenopodium ambrosioides / Q000737:chemistry*; D004357:Drug Synergism; D007891:Leishmania / Q000187:drug effects*; D008536:Meglumine / Q000494:pharmacology; D000077485:Meglumine Antimoniate; D051379:Mice; D009822:Oils, Volatile / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D010419:Pentamidine / Q000494:pharmacology; D010938:Plant Oils / Q000494:pharmacology*