title: Antibacterial stilbenoids from the roots of Stemona tuberosa.
abstract: Twelve dihydrostilbenes, stilbostemins N-Y (1-12), and a phenanthraquinone, stemanthraquinone (13), were isolated and identified from roots of Stemona tuberosa, along with five known dihydrostilbenes. Their structures were established on the basis of 1D and 2D NMR and other spectroscopic analyses. Dihydrostilbene 8 exhibited strong activity against Bacillus pumilus (MIT 12.5-25 microg/mL). Many tested compounds exhibited moderate antibacterial activities.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Zhangjiang Hi-tech Park, Shanghai 201203, PR China.
authors.forename: Li-Gen
authors.initials: LG
authors.lastname: Lin
authors.forename: Xin-Zhou
authors.initials: XZ
authors.lastname: Yang
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Tang
authors.forename: Chang-Qiang
authors.initials: CQ
authors.lastname: Ke
authors.forename: Ji-Bao
authors.initials: JB
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Ye
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D041901:Stemonaceae / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*