Mouse models of inflammatory bowel disease.
Animal models of intestinal inflammation are indispensable for our understanding of the pathogenesis of Crohn disease and Ulcerative colitis, the idiopathic forms of inflammatory bowel disease in humans. The clinical appearance of human IBD is heterogeneous, a fact that is also reflected by the steadily increasing number of mouse strains displaying IBD like intestinal alterations. The analysis of these models together with genetic studies in humans greatly enhanced our insights into immunoregulatory processes in the gut and led to the generally accepted hypothesis that a deregulated immune response against components of the intestinal microbiota is critically involved in IBD pathophysiology. In this article we provide a brief overview of selected mouse models of IBD and discuss their contribution to the current understanding of disease mechanisms that contribute to IBD.
Wirtz
Stefan
S
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany. wirtz@uni-mainz.de
Neurath
Markus F
MF
D000818:Animals; D015820:Cadherins / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D015212:Inflammatory Bowel Diseases / Q000209:etiology* / Q000276:immunology; D016753:Interleukin-10 / Q000172:deficiency; D051379:Mice; D008822:Mice, Transgenic; D016328:NF-kappa B / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000172:deficiency; D050797:STAT4 Transcription Factor / Q000235:genetics