title: Familial childhood systemic lupus erythematosus: report of 2 cases.
abstract: Systemic lupus erythematosus is a multisystem organ inflammation due to damage of cells and tissues by pathogenic auto-antibodies and immune complexes. The most important factor for the causation of familial systemic lupus erythematosus is genetic on which environmental factor usually coexists. Two brothers of 7 and 3 years of age having childhood systemic lupus erythematosus are reported here because of low incidence and familial occurrence. Both the children fulfilled the American Rheumatology Association (ARA) criterion of systemic lupus erythematosus though anti-dsDNA was negative in both and antinuclear factor was positive only in the younger child. Systemic lupus erythematosus begins in childhood in 20% of adult patients and usually after the age of 8 years but here onset was even at an earlier age. The treatment of the both the siblings included administration of steroids and cyclophosphamide.
authors.affiliation: Department of Skin, STD and Leprosy, NRS Medical College and Hospital, Kolkata 700014.
authors.forename: Alok Kumar
authors.initials: AK
authors.lastname: Roy
authors.forename: Dilip
authors.initials: D
authors.lastname: Pal
authors.forename: Sudip
authors.initials: S
authors.lastname: Das
authors.forename: Chinmoy
authors.initials: C
authors.lastname: Kar
authors.forename: Arunasis
authors.initials: A
authors.lastname: Maiti
mesh_terms: D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D004334:Drug Administration Schedule; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D035781:Siblings