title: Infection reduction using antibiotic-coated inflatable penile prosthesis.
abstract: OBJECTIVE
  Inflatable penile prosthesis (IPP) infection remains a devastating surgical complication. American Medical Systems recently introduced an IPP with a coating of minocycline HCL and rifampin (InhibiZone). We report our experience with this coating and compare the rate of infection with our historical rate.
  
  
  METHODS
  A total of 467 patients receiving InhibiZone-coated IPPs were followed up for infection. The patients were stratified into four groups: nondiabetic, first-time (virgin) implants; diabetic, virgin implants; revision without washout; and revision with antiseptic solution washout. All patients were observed for longer than 1 year. The infection rates were compared with our published data of noncoated IPPs.
  
  
  RESULTS
  No infections developed among the 223 virgin implants in nondiabetic patients. Of the 83 diabetic patients with virgin implants, 1 developed an infection (1%). Of the 39 revision patients without washout, 4 (10%) had infections. When an antiseptic washout was used in patients requiring revision, the infection rate dropped to 3% (4 of 123). Compared with our previous publications of infection rates with noncoated implants, InhibiZone-coated IPPs showed a statistically significant reduction in infection in virgin nondiabetic, virgin diabetic, and revision with washout implants. No reduction in the infection rate occurred among revision patients without washout.
  
  
  CONCLUSIONS
  Antibiotic-coated implants become infected less often in virgin, nondiabetic and virgin, diabetic patients than in our historical experience with noncoated implants. However, antibiotic-coated implants used in revision surgery did not reduce the infection rate unless adjunctive antiseptic solution washout was also used.
authors.affiliation: University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Wilson
authors.forename: Jurgen
authors.initials: J
authors.lastname: Zumbe
authors.forename: Gerard D
authors.initials: GD
authors.lastname: Henry
authors.forename: Emad A
authors.initials: EA
authors.lastname: Salem
authors.forename: John R
authors.initials: JR
authors.lastname: Delk
authors.forename: Mario A
authors.initials: MA
authors.lastname: Cleves
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D006801:Humans; D008297:Male; D015917:Penile Prosthesis / Q000009:adverse effects*; D011446:Prospective Studies; D016459:Prosthesis-Related Infections / Q000209:etiology* / Q000517:prevention & control*