Orthopedic metal immune hypersensitivity.
For many patients, the metals used in contemporary joint replacement surgery produce little or no reaction from the immune system. In a small but significant percentage of patients, however, a very rapid, T cell-mediated, allergic response may occur. If untreated, this reaction may ultimately lead to implant failure. Diagnosis may be complicated, and no effective treatments are available. Fortunately, alternative materials show great promise.
Nasser
Sam
S
Department of Orthopedic Surgery, Wayne State University School of Medicine, Detroit, MI, USA.
D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects / Q000295:instrumentation*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D007720:Knee Prosthesis / Q000009:adverse effects*; D008670:Metals / Q000009:adverse effects*; D008875:Middle Aged; D012086:Reoperation; D012882:Skin Tests