A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder.
Lithium is one of the most commonly used drugs for the treatment of bipolar disorder. To prescribe lithium appropriately to patients, predictors of response to this drug were explored, and several genetic markers are considered to be good candidates. We previously reported a significant association between genetic variations in the breakpoint cluster region (BCR) gene and bipolar disorder. In this study, we examined a possible relationship between response to maintenance treatment of lithium and Asn796Ser single-nucleotide polymorphism in the BCR gene. Genotyping was performed in 161 bipolar patients who had been taking lithium for at least 1 year, and they were classified into responders for lithium mono-therapy and non-responders. We found that the allele frequency of Ser796 was significantly higher in non-responders than in responders. Further investigation is warranted to confirm our findings.
Masui
Takuya
T
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Hokkaido, Japan.
Hashimoto
Ryota
R
Kusumi
Ichiro
I
Suzuki
Katsuji
K
Tanaka
Teruaki
T
Nakagawa
Shin
S
Suzuki
Tatsuyo
T
Iwata
Nakao
N
Ozaki
Norio
N
Kato
Tadafumi
T
Takeda
Masatoshi
M
Kunugi
Hiroshi
H
Koyama
Tsukasa
T
D000328:Adult; D000704:Analysis of Variance; D018692:Antimanic Agents / Q000627:therapeutic use*; D001216:Asparagine / Q000235:genetics; D001714:Bipolar Disorder / Q000145:classification / Q000235:genetics* / Q000517:prevention & control*; D010054:Brief Psychiatric Rating Scale; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D018020:Lithium Compounds / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense / Q000235:genetics*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051562:Proto-Oncogene Proteins c-bcr / Q000235:genetics*; D012694:Serine / Q000235:genetics