title: Prosthetic stent graft infection after endovascular abdominal aortic aneurysm repair.
abstract: OBJECTIVE
  The purpose of this report is to discuss the incidence, diagnosis, and management of stent graft infections after endovascular aneurysm repair (EVAR).
  
  
  METHODS
  Data were collected from the hospital database and medical case notes for all patients with infected endografts after elective or emergency EVAR for abdominal aortic aneurysm (AAA) during the last 8 years in two university teaching hospitals in Northern Ireland. The data included the patient's age, gender, presentation of sepsis, treatment offered, and the ultimate outcome. The diagnosis of graft-related sepsis was established by a combination of investigations including inflammatory markers, labelled white cell scan, computed tomography (CT) scan, microbiology cultures, and postmortem examination.
  
  
  RESULTS
  Graft-related septic complications occurred in six of 509 patients, including 433 elective repairs and 76 emergency endografts for ruptured AAA. Two patients presented with left psoas abscess and were treated successfully with extra-anatomic bypass and removal of the infected stent graft. Two more patients presented with infected graft without other evidence of intra-abdominal sepsis: one underwent successful removal of the infected prosthesis with extra-anatomical bypass, and the other was treated conservatively and died of progressively worsening sepsis. The fifth patient presented with unexplained fever and died suddenly, with a postmortem diagnosis of aortoenteric fistula and ruptured aneurysm. The last patient presented with an aortoenteric fistula, was treated conservatively in view of concurrent myelodysplasia, and died of possible aneurysm rupture.
  
  
  CONCLUSIONS
  This report emphasizes the need for continued awareness of potential graft-related septic complications in patients undergoing EVAR of AAA. Attention to detail with regard to sterility and antibiotic prophylaxis during stent grafting and during any secondary interventions is vital in reducing the risk of infection. In addition, early recognition and prompt treatment are essential for a successful outcome.
authors.affiliation: Department of Vascular and Endovascular Surgery, Belfast City Hospital, Belfast, United Kingdom. aneessharif@yahoo.co.uk
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Sharif
authors.forename: Bernard
authors.initials: B
authors.lastname: Lee
authors.forename: Luk L
authors.initials: LL
authors.lastname: Lau
authors.forename: Peter K
authors.initials: PK
authors.lastname: Ellis
authors.forename: Anton J
authors.initials: AJ
authors.lastname: Collins
authors.forename: Paul H
authors.initials: PH
authors.lastname: Blair
authors.forename: Chee V
authors.initials: CV
authors.lastname: Soong
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis / Q000601:surgery*; D001419:Bacteria / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D001807:Blood Vessel Prosthesis / Q000009:adverse effects* / Q000382:microbiology; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects*; D019160:Endosonography; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D014057:Tomography, X-Ray Computed