Rumphellolides A-F, six new caryophyllane-related derivatives from the Formosan Gorgonian coral Rumphella antipathies.
Six new caryophyllane-related natural products, including two carboxylated sesquiterpenoids, rumphellolides A (1) and B (2), and four norsesquiterpene alcohols, rumphellolides C-F (3-6), were isolated from the Formosan gorgonian coral Rumphella antipathies. The structures of the above new natural products were established on the basis of extensive spectral data analysis. Rumphellolides A (1), D (4), E (5), and F (6) showed weak antibacterial activity.
Sung
Ping-Jyun
PJ
National Museum of Marine Biology and Aquarium, Checheng, Pingtung, Taiwan, ROC. pjsung@nmmba.gov.tw
Chuang
Li-Fan
LF
Kuo
Jimmy
J
Chen
Jih-Jung
JJ
Fan
Tung-Yung
TY
Li
Jan-Jung
JJ
Fang
Lee-Shing
LS
Wang
Wei-Hsien
WH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005612:Freeze Drying; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013211:Staphylococcus aureus / Q000187:drug effects; D014736:Vibrio parahaemolyticus / Q000187:drug effects