Dillapiol and Apiol as specific inhibitors of the biosynthesis of aflatoxin G1 in Aspergillus parasiticus.
Dillapiol was isolated from the essential oil of dill as a specific inhibitor of aflatoxin G1 production. It inhibited aflatoxin G1 production by Aspergillus parasiticus with an IC50 value of 0.15 microM without inhibiting aflatoxin B1 production or fungal growth. Apiol and myristicin, congeners of dillapiol, showed similar activity with IC50 values of 0.24 and 3.5 microM, respectively.
Razzaghi-Abyaneh
Mehdi
M
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Yoshinari
Tomoya
T
Shams-Ghahfarokhi
Masoomeh
M
Rezaee
Mohammad-Bagher
MB
Nagasawa
Hiromichi
H
Sakuda
Shohei
S
D000348:Aflatoxins / Q000096:biosynthesis* / Q000737:chemistry*; D000498:Allyl Compounds; D001230:Aspergillus / Q000737:chemistry*; D004149:Dioxoles / Q000737:chemistry*; D015394:Molecular Structure; D000081248:Allylbenzene Derivatives