[Laparoscopy and digital subtraction angiography in the treatment of severe acute pancreatitis].
OBJECTIVE
To study the effect of laparoscopy and digital subtraction angiography in the treatment of severe acute pancreatitis (SAP).


METHODS
Seventy-five SAP patients were randomly divided into tow groups: (1) Conventional treatment group (group A, n = 35); (2) Conventional treatment combined with laparoscopy and digital subtraction angiography treatment group (group B, n = 40). The clinical parameters and treatment results in the 2 groups were compared.


RESULTS
After treatment, APACHE II score in group B was significantly lower than that in group A (P < 0.05). The functions of liver, renal and lung were recovered (P < 0.05, respectively), levels of serum TNF-alpha and IL-1 beta were significantly lower, but IL-10 significantly elevated (P < 0.05), the CT SPN was much lower (P < 0.05); rate of organ failure significantly decreased (P < 0.01), the successful rate of organ failure treatment was increased (P < 0.05); the in hospital mortality decreased (all P < 0.05).


CONCLUSIONS
Laparoscopy and digital subtraction angiography in combination with conventional treatment for SAP significantly improves the outcome and decrease the mortality of SAP.
Chen
Kai-yun
KY
Department of Minimal Invasive Surgery Center, Second People's Hospital of Guangdong Province, Guangzhou 510317, China. chky3213300@126.com
Xiang
Guo-an
GA
Wang
Han-ning
HN
Gao
Peng
P
Xiao
Fang-lian
FL
D018806:APACHE; D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction / Q000379:methods*; D003131:Combined Modality Therapy; D004358:Drug Therapy / Q000379:methods; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood