title: Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China.
abstract: OBJECTIVE
  To determine the occurrence rate, outcomes, and the characteristics of severe sepsis in surgical intensive care units in multiple medical centers within China and to assess the cost and resource use of severe sepsis in China.
  
  
  METHODS
  Prospective, observational study of surgical intensive care unit patients at ten university hospitals in six provinces in China.
  
  
  METHODS
  All adult admissions in studied intensive care units from December 1, 2004, to November 30, 2005.
  
  
  METHODS
  None.
  
  
  RESULTS
  The criteria of severe sepsis were based on the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definition. Analysis of data from 3,665 intensive care unit admissions identified 318 (8.68%) cases of severe sepsis, 64.8% of which were men. The median age (interquartile range) of patients with severe sepsis was 64 (47-74) yrs. Microbes had been isolated from 228 (71.7%) patients, including 171 (53.8%) with Gram-negative bacteria and 146 (45.9%) with Gram-positive bacteria. A total of 90 (22.0%) patients had invasive fungal infection, 20 (6.3%) of which had fungemia. The abdomen was the most common site of infections (72.3%), followed by lung (52.8%). The overall hospital mortality of severe sepsis was 48.7%. Risk factors for hospital mortality included age, chronic comorbidity of malignant neoplasm, Gram-positive bacterial infection, invasive fungal infection, admission Acute Physiology Score, and admission Sequential Organ Failure Assessment score of respiratory dysfunction and cardiovascular dysfunction. The median Therapeutic Intervention Scoring System-28 score was 43 (38-49). The mean hospital cost was $11,390 per patient and $502 per patient per day.
  
  
  CONCLUSIONS
  Severe sepsis is a common, expensive, and frequently fatal syndrome in critically ill surgical patients in China. Other than the microbiological patterns, the incidence, mortality, and major characteristics of severe sepsis in Chinese surgical intensive care units are close to those documented in developed countries.
authors.affiliation: Department of Anesthesiology, Intensive Care Unit, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Baoli
authors.initials: B
authors.lastname: Cheng
authors.forename: Guohao
authors.initials: G
authors.lastname: Xie
authors.forename: ShangLong
authors.initials: S
authors.lastname: Yao
authors.forename: Xinmin
authors.initials: X
authors.lastname: Wu
authors.forename: Qulian
authors.initials: Q
authors.lastname: Guo
authors.forename: Miaoning
authors.initials: M
authors.lastname: Gu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fang
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Xu
authors.forename: Dongxin
authors.initials: D
authors.lastname: Wang
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Jin
authors.forename: ShiYing
authors.initials: S
authors.lastname: Yuan
authors.forename: Junlu
authors.initials: J
authors.lastname: Wang
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Du
authors.forename: Yunbo
authors.initials: Y
authors.lastname: Sun
authors.forename: XiangMing
authors.initials: X
authors.lastname: Fang
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D016638:Critical Illness; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D011446:Prospective Studies; D018805:Sepsis / Q000453:epidemiology*; D012720:Severity of Illness Index