title: Utility of ultrasound and fine-needle aspiration biopsy of the axilla in the assessment of invasive lobular carcinoma of the breast.
abstract: BACKGROUND
  The unique growth pattern of invasive lobular carcinoma (ILC) poses a challenge for preoperative assessment of disease extent within the breast. Whether it similarly limits lymph node staging by ultrasound (US) and fine-needle aspiration (FNA) biopsy was the subject of the current study.
  
  
  METHODS
  A total of 217 patients with ILC who underwent axillary US were reviewed. FNA biopsy was performed when US findings were suspicious or indeterminate. Findings were compared to literature reports of US in invasive ductal carcinoma (IDC) patients.
  
  
  RESULTS
  Axillary US was negative in 137 patients (63%) and suspicious or indeterminate in 80 patients (37%). FNA biopsy was positive in 62% (47/76 patients). Preoperative US and FNA biopsy identified 43 of 111 (39%) node-positive patients. Sensitivity of US with FNA biopsy correlated with primary tumor and nodal metastasis size. Similar results were seen in IDC populations.
  
  
  CONCLUSIONS
  US with FNA biopsy appears to be similarly useful in axillary staging of ILC and IDC patients.
authors.affiliation: Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, 1400 Holcombe Blvd, Houston, TX 77030, USA.
authors.forename: Judy C
authors.initials: JC
authors.lastname: Boughey
authors.forename: Lavinia P
authors.initials: LP
authors.lastname: Middleton
authors.forename: Lori
authors.initials: L
authors.lastname: Harker
authors.forename: Betsy
authors.initials: B
authors.lastname: Garrett
authors.forename: Bruno
authors.initials: B
authors.lastname: Fornage
authors.forename: Kelly K
authors.initials: KK
authors.lastname: Hunt
authors.forename: Gildy V
authors.initials: GV
authors.lastname: Babiera
authors.forename: Peter
authors.initials: P
authors.lastname: Dempsey
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bedrosian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014463:Ultrasonography