[Environmental dioxin compounds as the cause of endometriosis and other diseases].
There has been much debate of late about whether or not dioxin, an industrial toxin, could be a causative agent in the onset of endometriosis, a gynaecological disease associated with infertility and pain. Studies found either no difference in serum dioxin concentrations when cases were compared to controls or a non-significant increase, or reached low statistical power. The introductory results on Rhesus monkey contradict with the observations on mice fed with dioxin and oestrogen simultaneously. Genetic comparison shows that human belongs to the dioxin resistant races so dioxin concentrations measured in the population could not cause disease especially not an oestrogen dependent one, like endometriosis.
Simsa
Péter
P
Országos Gyógyintézeti Központ, Nogyógyászati Osztály, Budapest. sqpeter@yahoo.com
Járási
Zsuzsanna Eva
ZE
Fülöp
Vilmos
V
D000818:Animals; D004147:Dioxins / Q000633:toxicity*; D004715:Endometriosis / Q000139:chemically induced*; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006801:Humans; D008253:Macaca mulatta; D051379:Mice