Inhibition of PI3K synergistically enhances the apoptotic effect of STI-571 on p210(bcr-abl)-transformed cells in a Rac1-dependent manner.
Rioux-Bilan
Agnès
A
Daubon
Thomas
T
Morel
Franck
F
Kitzis
Alain
A
Bourmeyster
Nicolas
N
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001549:Benzamides; D002461:Cell Line, Transformed; D004357:Drug Synergism; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism; D006801:Humans; D000068877:Imatinib Mesylate; D051379:Mice; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010879:Piperazines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D020830:rac1 GTP-Binding Protein / Q000502:physiology*