Memory CD8+ T cell differentiation in viral infection: a cell for all seasons.
Chronic viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are major global health problems affecting more than 500 million people worldwide. Virus-specific CD8+ T cells play an important role in the course and outcome of these viral infections and it is hypothesized that altered or impaired differentiation of virus-specific CD8+ T cells contributes to the development of persistence and/or disease progression. A deeper understanding of the mechanisms responsible for functional differentiation of CD8+ T cells is essential for the generation of successful therapies aiming to strengthen the adaptive component of the immune system.
Radziewicz
Henry
H
Emory University School of Medicine, 954 Gatewood Road, NE, Atlanta, GA 30329, United States.
Uebelhoer
Luke
L
Bengsch
Bertram
B
Grakoui
Arash
A
D000956:Antigens, Viral / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology* / Q000821:virology; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D007156:Immunologic Memory / Q000502:physiology*; D018448:Models, Immunological