title: Juvenile hormone activity of ethyl 4-(2-aryloxyhexyloxy)benzoates with precocious metamorphosis-inducing activity.
abstract: Ethyl 4-[2-(6-methyl-3-pyridyloxy)hexyloxy]benzoate (1) and ethyl 4-(2-phenoxyhexyloxy)benzoate (2), which induce precocious metamorphosis in larvae of Bombyx mori, a clear sign of juvenile hormone (JH) deficiency, showed JH activity when topically applied to allatectomized 4th instar larvae of B. mori. Compounds 1 and 2 induced precocious metamorphosis with doses at which they were effective as JH agonists.
authors.affiliation: Laboratory of Pesticide Chemistry, Department of Applied Genetics and Pest Management, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Fujita
authors.forename: Kiyo
authors.initials: K
authors.lastname: Ashibe
authors.forename: Naotaka
authors.initials: N
authors.lastname: Yamada
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shiotsuki
authors.forename: Makoto
authors.initials: M
authors.lastname: Kiuchi
authors.forename: Eiichi
authors.initials: E
authors.lastname: Kuwano
mesh_terms: D000818:Animals; D019817:Benzoic Acid / Q000737:chemistry* / Q000494:pharmacology*; D012831:Bombyx / Q000187:drug effects* / Q000254:growth & development*; D007605:Juvenile Hormones / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D008675:Metamorphosis, Biological / Q000187:drug effects*; D015394:Molecular Structure