title: What is the role of radiotherapy in the treatment of mucosal melanoma of the head and neck?
abstract: Mucosal melanoma of the head and neck is a rare, poor prognosis tumour with a high tendency to recur locally and regionally after surgical resection. A number of centres have used radiotherapy to sterilize positive and close margins after non-radical surgery or to treat inoperable cases. The present article discusses the literature data to analyze the possible indications for radiotherapy in terms of patient selection and treatment strategy. In the majority of the available retrospective series, postoperative radiotherapy improves the local control of mucosal melanomas, but its effect on survival has not yet been sufficiently investigated. Radiobiological studies show a high heterogeneity in behaviour of irradiated melanoma cells and the clinical implications of this will be illustrated. In the future, a better understanding of the radiosensitivity of this rare tumour and the availability of new technical modalities might allow for a more profitable incorporation of radiotherapy into a multidisciplinary strategy.
authors.affiliation: Department of Radiotherapy, Hospital Maggiore, University of Piemonte Orientale, Corso Mazzini, 18-28100 Novara, Italy. krengli@med.unipmn.it
authors.forename: Marco
authors.initials: M
authors.lastname: Krengli
authors.forename: Barbara Alicja
authors.initials: BA
authors.lastname: Jereczek-Fossa
authors.forename: Johannes H A M
authors.initials: JH
authors.lastname: Kaanders
authors.forename: Laura
authors.initials: L
authors.lastname: Masini
authors.forename: Debora
authors.initials: D
authors.lastname: Beldì
authors.forename: Roberto
authors.initials: R
authors.lastname: Orecchia
mesh_terms: D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D011379:Prognosis; D015996:Survival Rate