title: The prognostic significance of E-cadherin and liver intestine-cadherin expression in colorectal cancer.
abstract: OBJECTIVE
  The significance of liver intestine-cadherin as a potential marker has been growing in the field of oncology, because of its unique features compared with classic cadherins. We investigated the coexpression patterns of E-cadherin and liver intestine-cadherin in colorectal cancer, and determined whether differences in expression patterns were associated with clinicopathologic parameters and also which relationship between these two adhesion molecules existed in colorectal cancer.
  
  
  METHODS
  Expression pattern of E-cadherin and liver intestine-cadherin was investigated immunohistochemically in 207 colorectal cancers along with clinicopathologic parameters.
  
  
  RESULTS
  Reduced expression of liver intestine-cadherin was detected in 51 percent (n = 105) of tumors. Such expression was found to be associated with tumoral dedifferentiation (P = 0.015) and in a multivariate analysis was associated with a significant worse overall survival after adjustment for tumor stage, differentiation, and E-cadherin status (hazard ratio, 1.951; 95 percent confidence interval, 1.06-3.592; P = 0.032). Fifteen percent (n = 32) of tumors showed reduced expression of E-cadherin and had relationship with tumoral dedifferentiation (P < 0.001), lymph node metastasis (P = 0.004), and advanced stage (P = 0.029). Reduced expression of E-cadherin was associated with short overall survival (P = 0.028); however, in a multivariate analysis, it was not statistically significant.
  
  
  CONCLUSIONS
  Reduced expression of liver intestine-cadherin had a significant correlation with tumoral dedifferentiation and short overall survival in this series. In addition, early and frequent loss of liver intestine-cadherin expression might be a more sensitive indicator than E-cadherin to predict more aggressive tumoral behavior.
authors.affiliation: Department of Surgery, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Jung-Myun
authors.initials: JM
authors.lastname: Kwak
authors.forename: Byung-Wook
authors.initials: BW
authors.lastname: Min
authors.forename: Ju-Han
authors.initials: JH
authors.lastname: Lee
authors.forename: Jong-Sang
authors.initials: JS
authors.lastname: Choi
authors.forename: Sun-Il
authors.initials: SI
authors.lastname: Lee
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Park
authors.forename: Jin
authors.initials: J
authors.lastname: Kim
authors.forename: Jun-Won
authors.initials: JW
authors.lastname: Um
authors.forename: Seon-Han
authors.initials: SH
authors.lastname: Kim
authors.forename: Hong-Young
authors.initials: HY
authors.lastname: Moon
mesh_terms: D000368:Aged; D015820:Cadherins / Q000378:metabolism*; D002454:Cell Differentiation; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012680:Sensitivity and Specificity; D016019:Survival Analysis