title: Two cases of acute exacerbation of interstitial pneumonia treated with polymyxin B-immobilized fiber column hemoperfusion treatment.
abstract: The effect of polymixin B-immobilized fiber column (PMX) hemoperfusion treatment for acute exacerbation of interstitial pneumonia (IP) has been reported. Here, we report 2 cases of acute exacerbation of IP successfully treated with PMX hemoperfusion. One is a 55-year-old woman who was diagnosed as microscopic polyangiitis (MPA) with IP. The other is a 58-year-old man, diagnosed as having idiopathic pulmonary fibrosis. Both cases were treated with PMX hemoperfusion and other therapies. One died on day 44 and the other is still alive. The PMX hemoperfusion treatment decreased the serum levels of several cytokines and activated neutrophil percentage in bronchoalveolar lavage fluid.
authors.affiliation: Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Noma
authors.forename: Wataru
authors.initials: W
authors.lastname: Matsuyama
authors.forename: Hideo
authors.initials: H
authors.lastname: Mitsuyama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Suetsugu
authors.forename: Yoshimizu
authors.initials: Y
authors.lastname: Koreeda
authors.forename: Keiko
authors.initials: K
authors.lastname: Mizuno
authors.forename: Ikkou
authors.initials: I
authors.lastname: Higashimoto
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kakihana
authors.forename: Teruto
authors.initials: T
authors.lastname: Hashiguchi
authors.forename: Ikuro
authors.initials: I
authors.lastname: Maruyama
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Osame
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Arimura
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid; D017809:Fatal Outcome; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011112:Polymyxin B / Q000627:therapeutic use*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome