Exploring the effects of C-reactive protein (CRP) and interleukin-1 beta single nucleotide polymorphisms on CRP concentration in patients with established coronary artery disease. Classification tree approach.
OBJECTIVE
This study was designed to illustrate the effects of C-reactive protein (CRP) and interleukin polymorphisms on serum CRP levels.


METHODS
A total of 390 patients with coronary heart disease (CHD) were recruited and high-sensitivity CRP levels were measured. Six polymorphic alleles on the genes of CRP, IL-1, and the IL-1 receptor antagonist were identified. A classification tree was applied to determine their effects and interactions on serum CRP levels.


RESULTS
In the hypertensive CHD patients, the presence of CRP + 1059 GC heterozygotes was associated with a lower risk for elevated CRP levels (OR = 0.318, P = 0.001). The coexistence of CRP + 1059 GC and IL-1beta-511 (CT or TT) might result in reduction in the CRP levels compared to IL-1beta-511 CC (OR = 0.222, P = 0.088 and OR = 0.148, P = 0.060, respectively).


CONCLUSIONS
The results demonstrated the distribution of CRP-related polymorphisms and the interactions in Taiwanese patients with CHD.
Lin
Jou-Wei
JW
Cardiovascular Center, National Taiwan University Hospital, Yun-Lin Branch.
Dai
Dao-Fu
DF
Chou
Yi-Hua
YH
Huang
Li-Ying
LY
Hwang
Juey-Jen
JJ
D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002097:C-Reactive Protein / Q000032:analysis* / Q000235:genetics*; D003327:Coronary Disease / Q000097:blood* / Q000150:complications / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006801:Humans; D006973:Hypertension / Q000150:complications; D053583:Interleukin-1beta / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors / Q000235:genetics; D013624:Taiwan