title: Assessment of rabbit spleen size using ultrasonography.
abstract: Assessment of spleen size using the ultrasonography has become a standard practice in human. However, the assessment is not established method in experimental animals. To establish the index to assess the spleen size using ultrasonography, we measured the cross-section image of rabbit spleen during endotoxin shock. The image of the cross-section was appeared as triangle, and the height of the triangular image was defined as the spleen index. This spleen index showed strong correlation with the spleen weight. In conclusion, this method is suitable for observation of changes in rabbit spleen size and may reduce the number of rabbit in the longitudinal studies.
authors.affiliation: JIMRO Co., Ltd., Research Division, Takasaki, Gunma, Japan. takeday@jimro.co.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takeda
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Asaoka
authors.forename: Masamichi
authors.initials: M
authors.lastname: Ueno
authors.forename: Fumie
authors.initials: F
authors.lastname: Jimma
authors.forename: Mayumi
authors.initials: M
authors.lastname: Hidaka
authors.forename: Hiromu
authors.initials: H
authors.lastname: Shibusawa
authors.forename: Kenta
authors.initials: K
authors.lastname: Kaneda
authors.forename: Abbi R
authors.initials: AR
authors.lastname: Saniabadi
authors.forename: Katsuya
authors.initials: K
authors.lastname: Hiraishi
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Kashiwagi
mesh_terms: D000818:Animals; D009929:Organ Size; D011817:Rabbits / Q000033:anatomy & histology*; D013154:Spleen / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D014463:Ultrasonography