title: Effects of atelocollagen gel containing bone marrow-derived stromal cells on repair of osteochondral defect in a dog.
abstract: To clarify the contribution of autologous transplantation of mesenchymal stromal cells (MSCs), an atelocollagen gel containing or not containing fluorescently-labeled canine MSCs was transplanted into an osteochondral defect which did not repair spontaneously and the histological repair of the defect was compared. Although an early repair of the cartilage was not observed in either defect, the reproduction of subchondral bone was remarkable in the MSCs-implanted defect. Moreover, in 2 weeks after operation, the implanted MSCs were located in the deeper regions of the defect, suggesting the differentiation of osteoblasts. There was a possibility that the movement of the implanted MSCs was due to an increase in intra-articular pressure from postoperative inflammation.
authors.affiliation: Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan. yamazoe@gifu-u.ac.jp
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Yamazoe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mishima
authors.forename: Kentaro
authors.initials: K
authors.lastname: Torigoe
authors.forename: Hisashi
authors.initials: H
authors.lastname: Iijima
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sakai
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Kudo
mesh_terms: D000818:Animals; D003094:Collagen / Q000494:pharmacology*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D006614:Hindlimb; D007592:Joint Diseases / Q000628:therapy / Q000662:veterinary; D010007:Osteochondritis / Q000628:therapy / Q000662:veterinary*; D017154:Stromal Cells / Q000378:metabolism*; D013997:Time Factors