The potential role of chitin in allergic reactions.
Allergy, a potentially life-threatening condition, has at its heart an overly zealous T-helper type 2 response to environmental antigens. We are constantly flooded by potential allergens, both airborne and ingested. Although innocuous to some, common antigens can cause serious allergic reactions in susceptible individuals. Chitin, a polymerized sugar and fundamental component of arthropods and fungi, is not commonly deemed a potential allergen but can cause sensitization through frequent exposure. A recent intriguing study has highlighted the role of chitin in allergic reactions.
Burton
Oliver T
OT
Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK.
Zaccone
Paola
P
D000485:Allergens / Q000276:immunology*; D000818:Animals; D002686:Chitin / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000378:metabolism; D008262:Macrophage Activation; D018418:Th2 Cells / Q000276:immunology