N-glycosylthioureido aglyco-ristocetins without platelet aggregation activity.
The water-soluble N-methoxy-PEG-yl-, N-beta-D-glucopyranosyl- and N-beta-D-maltosylthioureido aglyco-ristocetin were prepared which, in contrast to ristocetin A, did not induce thrombocyte aggregation. The antibacterial activity of N-beta-D-maltosylthioureido aglyco-ristocetin A against MRSA was comparable to that of ristocetin A, while its activity against Enterococcus faecalis (VRE, TSE) is somewhat stronger when compared to those of vancomycin and ristocetin A.
Sztaricskai
Ferenc
F
Department of Pharmaceutial Chemistry, University of Debrecen.
Pintér
Gábor
G
Röth
Erzsébet
E
Herczegh
Pál
P
Kardos
Szilvia
S
Rozgonyi
Ferenc
F
Boda
Zoltán
Z
D001419:Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010974:Platelet Aggregation / Q000187:drug effects*; D012310:Ristocetin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*