Tête-à-tête: the function of FKBPs in plant development.
Compared with that of other eukaryotes, the nuclear genome of the model plant Arabidopsis thaliana encodes an expanded family of FK506-binding proteins (FKBPs). Whereas approximately half of the FKBPs are implicated in the regulation of photosynthetic processes, a subcluster appears to be stress responsive. Recent reports indicate that a discrete group of Arabidopsis multidomain FKBPs regulate plant hormone pathways by recruiting or modulating client proteins via direct protein-protein interactions (tête-à-tête). This suggests that multidomain FKBPs function as central elements in plant development by linking hormone responses with other signal transduction pathways. Here, we present a summary of current research demonstrating that, in addition to their role in protein folding, subsets of plant FKBPs exhibit diverse functionality.
Geisler
Markus
M
Zurich-Basel Plant Science Center, University of Zurich, Institute of Plant Biology, Zolliker Strasse 108, CH-8008 Zurich, Switzerland. markus.geisler@botinst.uzh.ch
Bailly
Aurélien
A
D000818:Animals; D002736:Chloroplasts / Q000378:metabolism; D010788:Photosynthesis; D063245:Plant Development; D010937:Plant Growth Regulators / Q000378:metabolism; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D022021:Tacrolimus Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*