The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.
We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.
Cuomo
Christina A
CA
Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
Güldener
Ulrich
U
Xu
Jin-Rong
JR
Trail
Frances
F
Turgeon
B Gillian
BG
Di Pietro
Antonio
A
Walton
Jonathan D
JD
Ma
Li-Jun
LJ
Baker
Scott E
SE
Rep
Martijn
M
Adam
Gerhard
G
Antoniw
John
J
Baldwin
Thomas
T
Calvo
Sarah
S
Chang
Yueh-Long
YL
Decaprio
David
D
Gale
Liane R
LR
Gnerre
Sante
S
Goswami
Rubella S
RS
Hammond-Kosack
Kim
K
Harris
Linda J
LJ
Hilburn
Karen
K
Kennell
John C
JC
Kroken
Scott
S
Magnuson
Jon K
JK
Mannhaupt
Gertrud
G
Mauceli
Evan
E
Mewes
Hans-Werner
HW
Mitterbauer
Rudolf
R
Muehlbauer
Gary
G
Münsterkötter
Martin
M
Nelson
David
D
O'donnell
Kerry
K
Ouellet
Thérèse
T
Qi
Weihong
W
Quesneville
Hadi
H
Roncero
M Isabel G
MI
Seong
Kye-Yong
KY
Tetko
Igor V
IV
Urban
Martin
M
Waalwijk
Cees
C
Ward
Todd J
TJ
Yao
Jiqiang
J
Birren
Bruce W
BW
Kistler
H Corby
HC
D004271:DNA, Fungal; D019143:Evolution, Molecular; D005670:Fusarium / Q000235:genetics* / Q000502:physiology; D016681:Genome, Fungal; D001467:Hordeum / Q000382:microbiology; D008969:Molecular Sequence Data; D010935:Plant Diseases / Q000382:microbiology; D017354:Point Mutation; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA