Effect of the benzylic structure of lignan on antioxidant activity.
The effect of the benzylic structure of lignan on antioxidant activity was evaluated. Secoisolariciresinol (1) and 3,4-bis(4-hydroxy-3-methoxybenzyl)tetrahydrofuran (2), which have two secondary benzylic positions without oxygen, showed the highest antioxidant activity. Optically active verrucosin (4) was synthesized for the first time in this experiment.
Yamauchi
Satoshi
S
Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan. syamauch@agr.ehime-u.ac.jp
Sugahara
Takuya
T
Matsugi
Junko
J
Someya
Tatsushi
T
Masuda
Toshiya
T
Kishida
Taro
T
Akiyama
Koichi
K
Maruyama
Masafumi
M
D000975:Antioxidants / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D017705:Lignans / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D013482:Superoxide Dismutase / Q000737:chemistry