title: N-{[(6-substituted-1,3-benzothiazole-2-yl)amino]carbonothioyl}-2/4-substituted benzamides: synthesis and pharmacological evaluation.
abstract: A series of 1,3-benzothiazol-2-yl benzamides (11-30) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity, CNS depressant study and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES and scPTZ screen and showed the decrease in the immobility time. None of the compounds had shown neurotoxicity or liver toxicity.
authors.affiliation: Hamdard University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, New Delhi 110 062, India.
authors.forename: Arpana
authors.initials: A
authors.lastname: Rana
authors.forename: Nadeem
authors.initials: N
authors.lastname: Siddiqui
authors.forename: Suroor A
authors.initials: SA
authors.lastname: Khan
authors.forename: Syed
authors.initials: S
authors.lastname: Ehtaishamul Haque
authors.forename: Mashooq A
authors.initials: MA
authors.lastname: Bhat
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001549:Benzamides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002492:Central Nervous System Depressants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity