LIGHT--a new member of the TNF superfamily in the plasma, dialysate and urine of uremic patients; the impact of residual diuresis and presence of viral hepatitis.
OBJECTIVE
LIGHT is a cytokine involved in atherosclerosis and cardiovascular disease in general population.


METHODS
We determined the levels of LIGHT in the plasma, dialysate and urine of uremic patients undergoing hemodialysis (HD) and healthy controls.


RESULTS
There were no significant differences in the pre and post-HD plasma levels of LIGHT between HD patients with residual diuresis (HD-RD) and HD anuric group (HD-A) compared to controls. HD-RD patients had the lower LIGHT values in dialysate compared to HD-A patients (p<0.001), and higher urinary LIGHT excretion compared to controls (p<0.05). Moreover, the presence of RD and chronic viral hepatitis were independent factors influencing the levels of this cytokine in dialysate.


CONCLUSIONS
The plasma levels of LIGHT seem to be similar in HD patients and healthy subjects and were not affected by gender, age, the mean period of HD history, disease etiology, type of medication and type of using dialysis membrane.
Pawlak
Krystyna
K
Department of Nephrology and Clinical Transplantation, Medical University, Bialystok, Poland. krystynapawlak@poczta.onet.pl
Pawlak
Dariusz
D
Mysliwiec
Michal
M
D000368:Aged; D015314:Dialysis Solutions / Q000032:analysis*; D004231:Diuresis; D005260:Female; D006525:Hepatitis, Viral, Human / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14 / Q000032:analysis* / Q000097:blood / Q000652:urine; D014511:Uremia / Q000378:metabolism / Q000628:therapy*