Benzaldehyde derivatives from Sarcodontia crocea.
Through bioactivity-guided fractionation, two volatile benzaldehyde derivatives ( 1 and 2) were isolated from a cellulose-matrix culture of the Basidiomycete Sarcodontia crosea (syn. S. setosa), where the fungus was grown on a growth medium-impregnated thick chromatographic paper. The structures of 1 and 2 were elucidated mainly by 2D NMR techniques as 4-(furan-3-yl)benzaldehyde and 4-(5-oxotetrahydrofuran-3-yl)benzaldehyde, respectively. Compound 1 is a new natural product, while 2 has been synthesized previously. They are considered to contribute to the odor of the fungus, which is an important character for identification of the species. They were weakly antifungal toward several phytopathogenic fungi but less potent against bacteria in microdilution assays.
Kokubun
Tetsuo
T
Jodrell Laboratory, Royal Botanic Gardens, Richmond, Surrey, UK. t.kokubun@kew.org
Rozwadowski
Zbigniew
Z
Duddeck
Helmut
H
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D027845:Malus / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D006113:United Kingdom