title: N-glycosylthioureido aglyco-ristocetins without platelet aggregation activity.
abstract: The water-soluble N-methoxy-PEG-yl-, N-beta-D-glucopyranosyl- and N-beta-D-maltosylthioureido aglyco-ristocetin were prepared which, in contrast to ristocetin A, did not induce thrombocyte aggregation. The antibacterial activity of N-beta-D-maltosylthioureido aglyco-ristocetin A against MRSA was comparable to that of ristocetin A, while its activity against Enterococcus faecalis (VRE, TSE) is somewhat stronger when compared to those of vancomycin and ristocetin A.
authors.affiliation: Department of Pharmaceutial Chemistry, University of Debrecen.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Sztaricskai
authors.forename: Gábor
authors.initials: G
authors.lastname: Pintér
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Röth
authors.forename: Pál
authors.initials: P
authors.lastname: Herczegh
authors.forename: Szilvia
authors.initials: S
authors.lastname: Kardos
authors.forename: Ferenc
authors.initials: F
authors.lastname: Rozgonyi
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Boda
mesh_terms: D001419:Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010974:Platelet Aggregation / Q000187:drug effects*; D012310:Ristocetin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*