Use of a composite pedicled muscle flap and rhBMP-7 for mandibular reconstruction.
The aim of this study was to investigate the feasibility of reconstructing critical size continuity osteoperiosteal defects of the mandible using a composite of recombinant BMP-7 contained in a bovine type-1 collagen carrier wrapped in a pedicled sterno-occipitalis muscle flap. At 3 months following surgery, bridging of the surgical defect was noted in three subjects (60%). Histologically, the induced bone regenerate showed maturation from woven to lamellar bone. Islands of cartilage were distributed throughout the defect. Replacement ossification of the degenerated muscle was a common feature in all specimens. Microradiography showed a gradual increase in the calcification of mineralized tissue from the margin to the centre of the newly generated bone. This research represents a proof of the concept that bone can be satisfactorily formed within a muscular scaffolding at the site of the created defect in a one-stage procedure.
Ayoub
A
A
Oral & Maxillofacial Surgery, Glasgow Dental Hospital & School, Glasgow, UK. a.ayoub@dental.gla.ac.uk <a.ayoub@dental.gla.ac.uk>
Challa
S R R
SR
Abu-Serriah
M
M
McMahon
J
J
Moos
K
K
Creanor
S
S
Odell
E
E
D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects*; D005240:Feasibility Studies; D008334:Mandible / Q000000981:diagnostic imaging / Q000601:surgery*; D008852:Microradiography / Q000379:methods; D009334:Neck Muscles / Q000601:surgery*; D011994:Recombinant Proteins / Q000627:therapeutic use; D019651:Plastic Surgery Procedures / Q000379:methods*; D012756:Sheep; D013524:Surgical Flaps; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*