Data and model integration using JWS Online.
Systems Biology requires a tight integration of experimental data and detailed computer models to obtain a quantitative understanding of the system under study. To facilitate this integration a standardization of data and model representation and storage is important. We illustrate here such an integration using JWS Online, the modeling tool developed in our group. We follow the approach of the Silicon Cell project for the construction and validation of kinetic models and discuss some issues with respect to storage of experimental data and models. The majority of the published kinetic models for biological systems have been developed for metabolic networks and this will be our focus in this manuscript. It is not our aim to present here an all encompassing method for data and model integration, but rather to present our work on this topic to start a discussion in which the different initiatives, methods and tools can be compared.
van Gend
Carel
C
Triple J Group for Molecular Cell Physiology, Department of Biochemistry, Stellenbosch University, Matieland 7602, South Africa.
Conradie
Riaan
R
du Preez
Franco B
FB
Snoep
Jacky L
JL
D002477:Cells / Q000378:metabolism*; D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D020407:Internet; D008954:Models, Biological; D009862:Online Systems; D012984:Software; D049490:Systems Biology