title: Pulse radiolysis study on free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one).
abstract: The reactions between edaravone and various one-electron oxidants such as (*)OH, N(3)(*), Br(2)(-), and SO(4)(-), have been studied by pulse radiolysis techniques. The transient species produced by the reaction of edaravone with (*)OH radical shows an absorption band with lambda(max)=320 nm, while the oxidation by N(3)(*), Br(2)(-), SO(4)(-) and CCl(3)OO(*) results in an absorption band with lambda(max)=345 nm. Different from the previous reports, the main transient species by the reaction of edaravone with (*)OH radical in the absence of O(2) is attributed to OH-adducts. At neutral condition (pH 7), the rate constants of edaravone reacting with (*)OH, N(3)(*), SO(4)(-), CCl(3)OO(*), and e(aq)(-) are estimated to be 8.5x10(9), 5.8x10(9), 6x10(8), 5.0x10(8) and 2.4x10(9)dm(3)mol(-1)s(-1), respectively. From the pH dependence on the formation of electron adducts and on the rate constant of edaravone with hydrated electron, the pK(a) of edaravone is estimated to be 6.9+/-0.1.
authors.affiliation: Advanced Science Research Center, Japan Atomic Energy Agency, 2-4 Shirakata Shirane, Tokaimura, Nakagun, Ibaraki 319-1195, Japan. lin.mingzhang@jaea.go.jp
authors.forename: Mingzhang
authors.initials: M
authors.lastname: Lin
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Katsumura
authors.forename: Kuniki
authors.initials: K
authors.lastname: Hata
authors.forename: Yusa
authors.initials: Y
authors.lastname: Muroya
authors.forename: Keichi
authors.initials: K
authors.lastname: Nakagawa
mesh_terms: D000042:Absorption; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000737:chemistry; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010084:Oxidation-Reduction; D011675:Pulse Radiolysis