Receptor editing: how B cells stay tolerant.
In 1993, David Nemazee and Martin Weigert independently showed that autoreactive B cells could proofread, alter, and reexpress modified receptors to become nonautoreactive. This process, called "receptor editing," has since gained prominence as the main mechanism of B cell tolerance.
Bashyam
Hema
H
hbashyam@rockefeller.edu
D000818:Animals; D001324:Autoantigens / Q000737:chemistry; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D007107:Immune System; D007108:Immune Tolerance; D051379:Mice; D008822:Mice, Transgenic; D011947:Receptors, Antigen, B-Cell / Q000502:physiology*