title: Solid-phase synthesis and thermal denaturation study of cyclic PNAs targeting the HIV-1 TAR RNA loop.
abstract: Cyclic PNAs targeting the HIV-1 TAR RNA loop have been synthesized following a convenient solid-phase strategy which allows on-resin cyclisation. UV-monitored thermal denaturation studies demonstrate that these cyclic PNAs are able to strongly interact with their TAR RNA target, very likely through the formation of a six-base pair stable complex, involving the TAR RNA loop.
authors.affiliation: Laboratoire de Chimie des Molécules Bioactives et des Arômes (LCMBA), UMR UNSA-CNRS 6001, Université de Nice-Sophia Antipolis, 06108 Nice Cedex 2, France.
authors.forename: Gregory
authors.initials: G
authors.lastname: Upert
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mehiri
authors.forename: Audrey
authors.initials: A
authors.lastname: Di Giorgio
authors.forename: Roger
authors.initials: R
authors.lastname: Condom
authors.forename: Nadia
authors.initials: N
authors.lastname: Patino
mesh_terms: D015497:HIV-1 / Q000235:genetics*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012367:RNA, Viral / Q000187:drug effects*; D013056:Spectrophotometry, Ultraviolet