title: Therapy of gastroesophageal reflux: evidence-based approach to antireflux surgery.
abstract: BACKGROUND
  Due to the chronic, relapsing nature of gastroesophageal reflux disease, lifelong therapeutic options have to be considered and recommended in many patients. Accordingly, surgical repair has to be evaluated based on modern, evidence-based methodologies.
  
  
  METHODS
  A careful review has been carried out of the relevant surgical literature also including trials incorporating direct comparisons between medical and surgical therapies. The outcome of such a survey has been structured according to the grading of evidence from highest grade I to the lowest III.
  
  
  RESULTS
  Grade I evidence exists to show that antireflux surgery is more effective than proton pump inhibition in the control of reflux-related symptoms. Side effects are burdening surgical repair, many of which do not decrease over time. Data are not consistent to show any benefit of surgery whenever health economic outcomes are required. Minor differences are in favor of laparoscopic operations and it does matter who is doing the operation and how the repair is completed. Better data are requested to assess the true long-term efficacy (>10 years) of corresponding operations.
  
  
  CONCLUSIONS
  Antireflux surgery is an effective and durable therapeutic modality in the long-term management of gastroesophageal reflux disease.
authors.affiliation: Department of Surgery, Karolinska University Hospital, Huddinge, Stockholm, Sweden. lars.lundell@karolinska.se
authors.forename: Lars
authors.initials: L
authors.lastname: Lundell
mesh_terms: D019317:Evidence-Based Medicine; D018662:Fundoplication / Q000009:adverse effects / Q000379:methods; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D018579:Patient Selection; D054328:Proton Pump Inhibitors