title: Use of a composite pedicled muscle flap and rhBMP-7 for mandibular reconstruction.
abstract: The aim of this study was to investigate the feasibility of reconstructing critical size continuity osteoperiosteal defects of the mandible using a composite of recombinant BMP-7 contained in a bovine type-1 collagen carrier wrapped in a pedicled sterno-occipitalis muscle flap. At 3 months following surgery, bridging of the surgical defect was noted in three subjects (60%). Histologically, the induced bone regenerate showed maturation from woven to lamellar bone. Islands of cartilage were distributed throughout the defect. Replacement ossification of the degenerated muscle was a common feature in all specimens. Microradiography showed a gradual increase in the calcification of mineralized tissue from the margin to the centre of the newly generated bone. This research represents a proof of the concept that bone can be satisfactorily formed within a muscular scaffolding at the site of the created defect in a one-stage procedure.
authors.affiliation: Oral & Maxillofacial Surgery, Glasgow Dental Hospital & School, Glasgow, UK. a.ayoub@dental.gla.ac.uk <a.ayoub@dental.gla.ac.uk>
authors.forename: A
authors.initials: A
authors.lastname: Ayoub
authors.forename: S R R
authors.initials: SR
authors.lastname: Challa
authors.forename: M
authors.initials: M
authors.lastname: Abu-Serriah
authors.forename: J
authors.initials: J
authors.lastname: McMahon
authors.forename: K
authors.initials: K
authors.lastname: Moos
authors.forename: S
authors.initials: S
authors.lastname: Creanor
authors.forename: E
authors.initials: E
authors.lastname: Odell
mesh_terms: D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects*; D005240:Feasibility Studies; D008334:Mandible / Q000000981:diagnostic imaging / Q000601:surgery*; D008852:Microradiography / Q000379:methods; D009334:Neck Muscles / Q000601:surgery*; D011994:Recombinant Proteins / Q000627:therapeutic use; D019651:Plastic Surgery Procedures / Q000379:methods*; D012756:Sheep; D013524:Surgical Flaps; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*