Fetal intervention for cardiac disease: the cutting edge of perinatal care.
Fetal cardiac valvuloplasty has been proposed for progressive cardiac disease with a poor prognosis, such as critical aortic stenosis and pulmonary atresia with intact ventricular septum and balloon atrial septostomy for hypoplastic left heart syndrome, or simple transposition of the great arteries with closed or restrictive inter-atrial communication. It is anticipated that early rescue of ventricles or the pulmonary veins from an unfavourable environment may promote healthier ventricular and vascular growth and improve postnatal outcomes. While close collaboration between the fetal medicine specialist and perinatal cardiologist may optimize the chances of technical success, obstacles to progress include the relative rarity of suitable cases and late referral for therapy. In common with other interventions in fetal medicine, there is a learning curve, and it would benefit progress if the procedures were initially concentrated in just a few centres to enable them to develop skills and experience. Following careful evaluation, it may then be desirable to train further centres and roll out best practice models.
Matsui
Hikoro
H
Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, Queen Charlotte's and Chelsea Hospital, Hammersmith Campus, London W12 ONH, UK.
Gardiner
Helena
H
D006348:Cardiac Surgical Procedures / Q000379:methods*; D002983:Clinical Competence; D018450:Disease Progression; D005260:Female; D005315:Fetal Diseases; D005318:Fetal Heart / Q000002:abnormalities* / Q000601:surgery*; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D011247:Pregnancy; D018570:Risk Assessment