Genetics of psoriasis and psoriatic arthritis.
Psoriasis and psoriatic arthritis are linked diseases characterised by (distinct ?) immune-mediated pathogenetic mechanisms and by a genetic background interacting with environmental factors. Some candidate susceptibility genes have been studied extensively; they include HLA genes, genes within the HLA region and genes outside the HLA region; among them corneodesmosin and other genes of PSORS1 region, MICA and TNF-a polymorphisms. The main findings in the literature are discussed.
Mathieu
A
A
Rheumatology Unit, University of Cagliari, Monserrato, Cagliari, Italy.
Cauli
A
A
Vacca
A
A
Mameli
A
A
Passiu
G
G
Porru
G
G
Piga
M
M
Ibba
V
V
Mura
V
V
Sanna
S
S
D000483:Alleles; D015535:Arthritis, Psoriatic / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics