title: Effect of excessive iodine on immune function of lymphocytes and intervention with selenium.
abstract: In order to study the effect of excessive iodine on immune function of lymphocytes and the role of selenium supplementation with excessive iodine intake, the changes of T lymphocyte number, ratio of subsets, activity of natural killer (NK) cells and lymphocytes proliferation response were investigated. 150 female BALB/C mice were randomly divided into 5 groups in terms of their body weight (n=30 in each group), and 10 of each group were taken as one batch for test. Mice in the 5 groups were orally administrated with iodine 0 (group I), 1500 (group II), 3000 (group III), 6000 microg/L (group IV), iodine 6000 microg/L plus selenium 0.3 mg/L (group V) respectively for 30 days Lymphocyte proliferation response, CD4(+)/CD8(+), Th1/Th2 and the activity of NK cells were measured. CD4(+)/CD8(+) was significantly lower, while lymphocyte proliferation response stronger, and Th1/Th2 and the activity of NK cells significantly higher in group IV than in group I (P<0.01). There was no significant difference in all indexes between group V and group I (P>0.05). It was suggested that excessive iodine as exogenous chemical materials can induce disorders of T lymphocyte immune function in mice. 0.3 mg/L selenium supplementation can protect mice against toxicity induced by 6000 microg/L iodine.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. wchenxy1@126.com
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Chen
authors.forename: Liegang
authors.initials: L
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Yao
authors.forename: Dong
authors.initials: D
authors.lastname: Yu
authors.forename: Liping
authors.initials: L
authors.lastname: Hao
authors.forename: Xiufa
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D016516:CD4-CD8 Ratio; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D007455:Iodine / Q000008:administration & dosage* / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D007694:Killer Cells, Natural / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D012643:Selenium / Q000494:pharmacology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology