Diagnosis of haemophilic synovitis.
The pathophysiology of haemophilic synovitis is complex and not as well understood on a molecular level as we have thought. The repeated bleeding episodes and synovial hypertrophy occurring within the joint. Iron and other red-cell debris are phagocytized, and hydrolytic enzymes are produced leading to the destruction of articular cartilage is a simplistic model. However, how iron stimulates this destructive cascade remains speculative and poorly understood. Diagnostic options include radiographic examination using horizontal beam technique, which may reveal a fat blood fluid level, and computed tomography scanning or magnetic resonance imaging.
Goddard
N J
NJ
Department of Orthopaedics, Royal Free Hospital, London, UK. njgoddardfrcs@aol.com
Mann
H
H
D002358:Cartilage, Articular / Q000503:physiopathology; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods; D005260:Female; D006395:Hemarthrosis / Q000175:diagnosis* / Q000503:physiopathology; D006467:Hemophilia A / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D013585:Synovitis / Q000175:diagnosis* / Q000503:physiopathology