"Atmospheric" Epoxidation of Benzo[a]pyrene by Ozone: Formation of the Metabolite Benzo[a]pyrene-4,5-Oxide.
Benzo[a]pyrene deposited on a glass fiber filter reacts rapidly in the dark or light with ambient levels of ozone to yield a mixture of products that display strong direct mutagenicity in the Ames assay. The major stable contributor to this activity has been identified as benzo[a]pyrene-4,5-oxide, a DNA-binding metabolite in biological systems, known to be a strong direct mutagen with Salmonella typhimurium strain TA98.
Pitts
J N
JN
Lokensgard
D M
DM
Ripley
P S
PS
VAN Cauwenberghe
K A
KA
VAN Vaeck
L
L
Shaffer
S D
SD
Thill
A J
AJ
Belser
W L
WL