title: Methodology of a real-time quality control for the multispectral digital colposcope (MDC).
abstract: BACKGROUND
  The diagnostic ability of algorithms developed for the Multispectral Digital Colposcope (MDC) is highly dependent on the quality of the image. The field of objective medical image quality analysis has great potential but has not been well exploited. Various researchers have reported different measures of image quality but with an existence of a reference image. The quality of an image can be attributed to several sources of errors, a few of which would be inclusion of presence of extraneous components, improper illumination, or an image out of focus. This can be due to motion artifact or the region of interest out of the focal plane.
  
  
  METHODS
  With spectroscopic measurements, assessment of data quality has been used by our group in the past to avoid hardware errors at the time of acquisition. We are currently developing algorithms that will help identify hardware and acquisition errors to the clinician in under a few seconds.
  
  
  RESULTS
  Minimizing these errors not only provides quality images for a diagnostic algorithm, but reduces the necessity for complex and time intensive post-processing software for enhancing the images.
  
  
  CONCLUSIONS
  We propose a no reference image quality system specifically designed for MDC that can be modified to similar spectroscopic imaging applications.
authors.affiliation: Biomedical Engineering Center, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: Senthilnathan
authors.initials: S
authors.lastname: Nakappan
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Park
authors.forename: Dan
authors.initials: D
authors.lastname: Serachitopol
authors.forename: Roderick
authors.initials: R
authors.lastname: Price
authors.forename: Mark
authors.initials: M
authors.lastname: Cardeno
authors.forename: Sylvia
authors.initials: S
authors.lastname: Au
authors.forename: Nick
authors.initials: N
authors.lastname: Mackinnon
authors.forename: Calum
authors.initials: C
authors.lastname: MacAulay
authors.forename: Michele
authors.initials: M
authors.lastname: Follen
authors.forename: Brian M
authors.initials: BM
authors.lastname: Pikkula
mesh_terms: D000465:Algorithms; D020681:Colposcopes; D003127:Colposcopy / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D011786:Quality Control; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000473:pathology