title: [Clinical study on lung disease caused by non-tuberculous mycobacteriosis in the elderly].
abstract: OBJECTIVE
  This study was done to clarify the characteristics of elderly patients with nontuberculous mycobacteriosis.
  
  
  METHODS
  We investigated the clinical features of 10 patients at an advanced age who had been given diagnosis of nontuberculous mycobacteriosis.
  
  
  RESULTS
  Mycobacterium avium intracellulare complex (MAC) were detected in all cases. The age of the patients ranged from 65 to 92. Four cases had underlying respiratory diseases (old pulmonary tuberculosis in 3 cases, pulmonary emphysema in 1 case, bronchiectasia in 1 case). Six cases suffered from dementia. The symptoms were relatively nonspecific, such as low grade fever, fatigue, appetite loss in almost all cases in this study. On computed tomography (CT) scans of the chest, mainly small nodular infiltrates were seen. MAC was detected in clinical samples such as sputum, gastric juice and bronchial lavage. The examination of gastric juice was performed in 6 out of the 10 cases. Gastric juice samples were smear-positive for acid-fast bacilli in 5 of 6, and culture-positive for MAC in 5 of 6. The detection of MAC in gastric juice samples was higher than that in sputum samples on admission.
  
  
  CONCLUSIONS
  Gastric juice might be useful to differentiate infection from casual isolation of MAC in elderly patients.
authors.affiliation: Department of General Medicine, Juntendo University School of Medicine, Juntendo, Japan.
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Sugihara
authors.forename: Takashi
authors.initials: T
authors.lastname: Dambara
authors.forename: Miyoji
authors.initials: M
authors.lastname: Aiba
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakajima
authors.forename: Akihiro
authors.initials: A
authors.lastname: Inui
authors.forename: Naomi
authors.initials: N
authors.lastname: Matsumoto
authors.forename: Naoko
authors.initials: N
authors.lastname: Hada
authors.forename: Akiko
authors.initials: A
authors.lastname: Katayama
authors.forename: Toshio
authors.initials: T
authors.lastname: Naito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Isonuma
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hayashida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis*