Cytotoxic turrianes of Kermadecia elliptica from the New Caledonian rainforest.
In the course of an automated screening for small molecules presenting cytotoxic activity, eight new cyclophanes named kermadecins A-H (1-8), have been isolated from the bark of a New Caledonian plant, Kermadecia elliptica, Proteaceae. A LC/APCI-MS study performed on kermadecins A, B and C, provided a reliable method for the detection of other analogues existing in small quantities in the extract. This led to the isolation of five other members of this chemical series. The structures were elucidated by extensive mono- and bi-dimensional spectroscopy and mass spectrometry. The cytotoxic activity of four of them was evaluated on various cell lines.
Jolly
Claire
C
Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
Thoison
Odile
O
Martin
Marie-Thérèse
MT
Dumontet
Vincent
V
Gilbert
Aline
A
Pfeiffer
Bruno
B
Léonce
Stéphane
S
Sévenet
Thierry
T
Guéritte
Françoise
F
Litaudon
Marc
M
D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009510:New Caledonia; D011891:Rain; D014329:Tropical Climate