Alpha-glucosidase inhibitors from Millettia conraui.
A new geranylated isoflavone, 7-O-geranyl-6-methoxypseudobaptigenin (1) was isolated from the stem barks of Millettia conraui, along with known compounds 5-methoxydurmillone (2), conrauinone A (3), beta-amyrine (4), sitosterol (5), 3-O-beta-D-glucopyranosyl sitosterol (6) and n-docosanol (7). Compounds 1 and 4 showed a significant alpha-glucosidase inhibitory activity. The structures of the compounds were determined by analysis of their spectroscopic data.
Tiabou Tchinda
Alembert
A
Center of Medicinal Plants Studies and Traditional Medicine (CRPMT), Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaaoundé, Cameroon. alembertt2002@yahoo.fr
Nahar Khan
Shamsun
S
Fuendjiep
Victorine
V
Ngandeu
François
F
Ngono Ngane
Annie
A
Choudhary
Muhammad Iqbal
MI
D017485:1-Deoxynojirimycin / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D033641:Millettia / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet