Tensyuic acids, new antibiotics produced by Aspergillus niger FKI-2342.
Six new alkylitaconic acids, designated tensyuic acids A to F, were isolated from the culture broth of Aspergillus niger FKI-2342 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analysis including UV, NMR, and MS. They are all alkylitaconic acid derivatives. Only tesyuic acid C showed moderate antimicrobial activity against Bacillus subtilis.
Hasegawa
Yoko
Y
Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Fukuda
Takashi
T
Hagimori
Keiichi
K
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013386:Succinates / Q000494:pharmacology*