Chloramphenicol: screening and review to evaluate its potential beneficial effects in leukaemia.
Chloramphenicol is an antimicrobial agent having a very broad-spectrum of activity including Gram-positive bacteria, Gram-negative bacteria and anaerobes. However the use of chloramphenicol has reduced over a period of time due to the adverse effects of causing bone marrow depression or in some cases severe aplastic anaemia. As the effects are seen on the bone marrow cell, it was intended to find out if these adverse effects could be used for the benefits in leukaemia patients, using in-vitro study on leukaemic cell lines. The study showed inhibition of growth of the leukaemia cells by chloramphenicol which was comparable to or better than daunorubicin in some cell lines. The article also discusses the other adverse effect profile of chloramphenicol compared with anticancer drugs and its potential benefit in leukaemia and in neutropenic fever.
Lokhande
J
J
Alkem Laboratories Ltd, Mumbai 400013.
Juvekar
A S
AS
Kulkarni
K P
KP
D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002701:Chloramphenicol / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D066298:In Vitro Techniques; D007938:Leukemia / Q000188:drug therapy*; D011500:Protein Synthesis Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*