Bioavailability and bioequivalence of topical glucocorticoids.
Dermatological therapy depends significantly upon the use of topical glucocorticoids (TG). While effective, and often remarkably so, their delivery into the skin is sometimes rather inefficient. The factors which determine drug efficacy, and the various methodologies, by which the rate and extent of TG transport to their sites of action may be assessed, are the foci of this review.
Wiedersberg
Sandra
S
Department of Pharmacy & Pharmacology, University of Bath, Bath, UK. swiedersberg@gmx.de
Leopold
Claudia S
CS
Guy
Richard H
RH
D000287:Administration, Topical; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D017551:Microdialysis; D014677:Pharmaceutical Vehicles; D013810:Therapeutic Equivalency