title: Reversal of hepatotoxin-induced pre-fibrogenic events by Emblica officinalis--a histological study.
abstract: Efficacy of a herbal product of E. officinalis (fruit) (EO) has been evaluated against carbon tetrachloride (CCl4) and thioacetamide (TAA) induced changes in rat liver. Chronic treatment of CCl4 and TAA revealed abnormal histopathology indicative of pre-fibrogenic events. EO reversed such alterations with significant regenerative changes suggestive of its preventive role in prefibrogenesis of liver.
authors.affiliation: Division of Pharmacology, Indian Institute of Integrative Medicine, (Formerly Regional Research Laboratory), Jammu-Tawi 180 001, India.
authors.forename: A I
authors.initials: AI
authors.lastname: Mir
authors.forename: B
authors.initials: B
authors.lastname: Kumar
authors.forename: S A
authors.initials: SA
authors.lastname: Tasduq
authors.forename: D K
authors.initials: DK
authors.lastname: Gupta
authors.forename: S
authors.initials: S
authors.lastname: Bhardwaj
authors.forename: R K
authors.initials: RK
authors.lastname: Johri
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D002273:Carcinogens / Q000032:analysis; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008103:Liver Cirrhosis; D029842:Phyllanthus emblica / Q000378:metabolism*; D010936:Plant Extracts / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013853:Thioacetamide / Q000494:pharmacology*; D014118:Toxins, Biological