Bioactive molecules from amphibian skin: their biological activities with reference to therapeutic potentials for possible drug development.
The amphibian skin contains various bioactive molecules (peptides, proteins, steroids, alkaloids, opiods) that possess potent therapeutic activities like antibacterial, antifungal, antiprotozoal, antidiabetic, antineoplastic, analgesic and sleep inducing properties. Research on amphibian skin derived biomolecules can provide potential clue towards newer drug development to combat various pathophysiological conditions. An overview on the bioactive molecules of various amphibian skins has been discussed.
Gomes
Antony
A
Laboratory of Toxinology and Experimental Pharmacodynamics, Department of Physiology, University of Calcutta, 92 A. P. C. Road, Kolkata 700 009, India. agomesc_u@gmail.com
Giri
Biplab
B
Saha
Archita
A
Mishra
R
R
Dasgupta
Subir C
SC
Debnath
A
A
Gomes
Aparna
A
D000663:Amphibians / Q000378:metabolism*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry; D002316:Cardiotonic Agents / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry; D012867:Skin / Q000378:metabolism*; D012879:Skin Physiological Phenomena