Targeting telomeres and telomerase.
Telomeres and telomerase represent, at least in theory, an extremely attractive target for cancer therapy. The objective of this review is to present the latest view on the mechanism(s) of action of telomerase inhibitors, with an emphasis on a specific class of telomere ligands called G-quadruplex ligands, and to discuss their potential use in oncology.
De Cian
Anne
A
INSERM, U565, Acides nucléiques: dynamique, ciblage et fonctions biologiques, 43 rue Cuvier, CP26, Paris Cedex 05, F-75231, France.
Lacroix
Laurent
L
Douarre
Céline
C
Temime-Smaali
Nassima
N
Trentesaux
Chantal
C
Riou
Jean-François
JF
Mergny
Jean-Louis
JL
D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D004249:DNA Damage / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism; D000089804:Shelterin Complex; D019098:Telomerase / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D016615:Telomere / Q000187:drug effects / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000378:metabolism