title: Limits of DPUI application associated with the number of particles within actinide aerosols.
abstract: Dose per unit intake (DPUI) of radionuclides is obtained using International Commission on Radiological Protection (ICRP) models. After inhalation exposure, the first model calculates the fraction of activity deposited within the different regions of the respiratory tract, assuming that the aerosol contains an infinite number of particles. Using default parameters for workers, an exposure to one annual limit of intake (ALI) corresponds to an aerosol of 239PuO2 containing approximately 1 x 10(6) particles. To reach such an exposure, very low particle number might be involved especially for compounds having a high specific activity. This study provides examples of exposures to actinide aerosols for which the number of particles is too low for a standard application of the ICRP model. These examples, which involve physical studies of aerosols collected at the workplace and interpretation of bioassay data, show that the number of particles of the aerosol can be the main limit for the application of DPUI after inhalation exposure.
authors.affiliation: Laboratoire de Radiotoxicologie, SRCA/DRR/DSV/CEA, BP 12, 91680 Bruyères le Châtel, France. paul.fritsch@cea.fr
authors.forename: P
authors.initials: P
authors.lastname: Fritsch
authors.forename: P
authors.initials: P
authors.lastname: Raynaud
authors.forename: N
authors.initials: N
authors.lastname: Blanchin
authors.forename: A
authors.initials: A
authors.lastname: Mièle
mesh_terms: D008671:Actinoid Series Elements / Q000493:pharmacokinetics*; D000280:Administration, Inhalation; D000284:Administration, Oral; D000336:Aerosols / Q000493:pharmacokinetics; D001681:Biological Assay / Q000379:methods*; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D006801:Humans; D008954:Models, Biological; D052638:Particulate Matter / Q000032:analysis* / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity