title: Rapid human immunodeficiency virus-1 testing on labor and delivery in 17 US hospitals: the MIRIAD experience.
abstract: The objective of the study was to evaluate the feasibility, acceptability, and accuracy of rapid human immunodeficiency virus (HIV) testing during labor. The Mother-Infant Rapid Intervention at Delivery (MIRIAD) study was a prospective, multicenter study that offered voluntary, rapid HIV testing to women with undocumented HIV status at 17 hospitals in 6 cities. Of 12,481 eligible women, 74% were approached for participation and 85.5% of those approached accepted rapid HIV testing. Among 7753 women tested, MIRIAD identified 52 (0.7%) HIV-infected women. The time between obtaining the blood sample for the rapid test and reporting the results to the health care provider was shorter for hospitals utilizing point-of-care testing than in hospitals utilizing laboratory-based testing (30 minutes vs 68 minutes; P < .0001), and point-of-care testing strategies were 14 times more likely to have a short turnaround as laboratory testing strategies. Routine rapid testing during labor provides a feasible, acceptable, and accurate way to identify HIV-infected women before delivery.
authors.affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. djj0@cdc.gov
authors.forename: Denise J
authors.initials: DJ
authors.lastname: Jamieson
authors.forename: Mardge H
authors.initials: MH
authors.lastname: Cohen
authors.forename: Robert
authors.initials: R
authors.lastname: Maupin
authors.forename: Steven
authors.initials: S
authors.lastname: Nesheim
authors.forename: Susan P
authors.initials: SP
authors.lastname: Danner
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Lampe
authors.forename: Mary Jo
authors.initials: MJ
authors.lastname: O'Sullivan
authors.forename: Mayris P
authors.initials: MP
authors.lastname: Webber
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Wiener
authors.forename: Rosalind J
authors.initials: RJ
authors.lastname: Carter
authors.forename: Yvette
authors.initials: Y
authors.lastname: Rivero
authors.forename: Mary Glenn
authors.initials: MG
authors.lastname: Fowler
authors.forename: Marc
authors.initials: M
authors.lastname: Bulterys
mesh_terms: D000328:Adult; D019411:Clinical Laboratory Techniques; D036861:Delivery, Obstetric; D005240:Feasibility Studies; D005260:Female; D015658:HIV Infections / Q000175:diagnosis*; D015497:HIV-1; D006761:Hospitals; D006801:Humans; D007124:Immunoenzyme Techniques; D007743:Labor, Obstetric / Q000097:blood*; D019095:Point-of-Care Systems; D011247:Pregnancy; D011446:Prospective Studies; D013997:Time Factors; D014481:United States