title: Structural changes to the fusiform gyrus: a cerebral marker for social impairments in 22q11.2 deletion syndrome?
abstract: Identifying the neural underpinnings of socio-emotional deficits in 22q11.2 deletion syndrome (22q11DS) may elucidate recurrent psychosis in affected individuals. In the current study, we investigate volumetric changes in 22q11DS to the fusiform gyrus (FG), a region associated with hypoactivity during fMRI, by manually tracing the FG in 42 individuals with 22q11DS and 54 healthy controls. Larger anterior FG volumes and smaller posterior volumes bilaterally are observed in 22q11DS after controlling for total brain volume. The results demonstrate structural changes to the FG in 22q11DS, providing evidence for neural vulnerability in regions related to social cognition.
authors.affiliation: Service Médico-Pédagogique, Department of Child Psychiatry, University of Geneva Medical School and University Hospitals, 16-18 bd St Georges, 1211 Geneva 8, Switzerland. bronwyn.glaser@medecine.unige.ch
authors.forename: Bronwyn
authors.initials: B
authors.lastname: Glaser
authors.forename: Marie
authors.initials: M
authors.lastname: Schaer
authors.forename: Sandra
authors.initials: S
authors.lastname: Berney
authors.forename: Martin
authors.initials: M
authors.lastname: Debbane
authors.forename: Patrik
authors.initials: P
authors.lastname: Vuilleumier
authors.forename: Stephan
authors.initials: S
authors.lastname: Eliez
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000033:anatomy & histology / Q000473:pathology; D002648:Child; D004062:DiGeorge Syndrome / Q000235:genetics / Q000473:pathology* / Q000523:psychology*; D005260:Female; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015588:Observer Variation; D012016:Reference Values