Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations.
BACKGROUND
Changes with aging in serum gonadal hormones, sex hormone-binding globulin (SHBG) and adiponectin, which are involved in insulin resistance and metabolic syndrome, are different in men and women. We examined the relationships of serum adiponectin concentrations with serum concentrations of hormones and SHBG in men and women.


METHODS
One hundred fifty-four men and 180 women aged from 50 to 85 years were included in the cross-sectional study. Serum concentrations of testosterone, estradiol, dehydroepiandrosterone-sulfate, SHBG and adiponectin were measured in men and women.


RESULTS
Serum adiponectin concentration showed a significant positive correlation with serum SHBG concentration in men and women (r=0.404, p<0.0001 and r=0.348, p<0.0001, respectively). Multiple regression analysis also showed that SHBG was the significant predictor for adiponectin in men and women. Serum adiponectin concentration in men showed a significant positive correlation with total testosterone concentration, but that in women was not significantly correlated with total testosterone concentration. Both adiponectin and SHBG concentrations in men (r=-0.222, p=0.0051 and r=-0.334, p<0.0001, respectively) and women (r=-0.281, p=0.0014 and r=-0.251, p=0.0048, respectively) showed significant negative correlations with the homeostasis model assessment (HOMA) index.


CONCLUSIONS
Correlations between adiponectin and SHBG were significantly positive in both men and women, and both adiponectin and SHBG might be involved in insulin resistance in both sexes.
Yasui
Toshiyuki
T
Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. yasui@clin.med.tokushima-u.ac.jp
Tomita
Junko
J
Miyatani
Yuka
Y
Yamada
Masayo
M
Uemura
Hirokazu
H
Irahara
Minoru
M
Arai
Makoto
M
Kojimahara
Noriko
N
Okabe
Ryugo
R
Ishii
Yasutomo
Y
Tashiro
Shin-ichi
S
Sato
Hiroshi
H
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015992:Body Mass Index; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D008954:Models, Biological; D012044:Regression Analysis; D018570:Risk Assessment; D012737:Sex Factors; D012738:Sex Hormone-Binding Globulin / Q000032:analysis* / Q000378:metabolism; D013739:Testosterone / Q000097:blood*