title: Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.
abstract: Five new benzylphenethylamine alkaloids, hostasine (1), 8-demethoxyhostasine, 8-demethoxy-10-O-methylhostasine, 10-O-methylhostasine, and 9-O-demethyl-7-O-methyllycorenine, along with 12 known compounds, were isolated from Hosta plantaginea by bioassay-guided fractionation. The structures of the new alkaloids were established by means of extensive spectroscopic methods, and the relative configuration of 1 was further confirmed by single-crystal X-ray diffraction. 7-Deoxy-trans-dihydronarciclasine (IC(50) = 1.80 microM), a known alkaloid, showed strong activity against tobacco mosaic virus by the half-leaf method. Some of these alkaloids were also evaluated for their inhibitory activity against acetylcholinesterase. 8-Demethoxy-10-O-methylhostasine was found to possess significant activity, with an IC(50) of 2.32 microM.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Zhong-Kai
authors.initials: ZK
authors.lastname: Zhang
authors.forename: Fu-Mei
authors.initials: FM
authors.lastname: Yang
authors.forename: Qian-Yun
authors.initials: QY
authors.lastname: Sun
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Mu
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Ying
authors.initials: Y
authors.lastname: Chang
authors.forename: Qi-Tai
authors.initials: QT
authors.lastname: Zheng
authors.forename: Ming
authors.initials: M
authors.lastname: Ding
authors.forename: Jia-Hong
authors.initials: JH
authors.lastname: Dong
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D031422:Hosta / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D014027:Tobacco Mosaic Virus / Q000187:drug effects*