title: Targeting telomeres and telomerase.
abstract: Telomeres and telomerase represent, at least in theory, an extremely attractive target for cancer therapy. The objective of this review is to present the latest view on the mechanism(s) of action of telomerase inhibitors, with an emphasis on a specific class of telomere ligands called G-quadruplex ligands, and to discuss their potential use in oncology.
authors.affiliation: INSERM, U565, Acides nucléiques: dynamique, ciblage et fonctions biologiques, 43 rue Cuvier, CP26, Paris Cedex 05, F-75231, France.
authors.forename: Anne
authors.initials: A
authors.lastname: De Cian
authors.forename: Laurent
authors.initials: L
authors.lastname: Lacroix
authors.forename: Céline
authors.initials: C
authors.lastname: Douarre
authors.forename: Nassima
authors.initials: N
authors.lastname: Temime-Smaali
authors.forename: Chantal
authors.initials: C
authors.lastname: Trentesaux
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Riou
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mergny
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D004249:DNA Damage / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism; D000089804:Shelterin Complex; D019098:Telomerase / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D016615:Telomere / Q000187:drug effects / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000378:metabolism