Recoverable (R)- and (S)-binap-Ag(I) complexes for the enantioselective 1,3-dipolar cycloaddition reaction of azomethine ylides.
The first enantioselective 1,3-dipolar cycloaddition reaction of amino acid derived azomethine ylides and maleimides catalyzed by very stable and recyclable chiral (R)- or (S)-binap-AgClO(4) complexes is described. The reactions are performed at room temperature, in good yields, with high endo diastereoselectivity and enantioselectivity, the complex being recovered by simple filtration.
Nájera
Carmen
C
Departamento de Química OrgAnica and Instituto de Síntesis OrgAnica (ISO), Facultad de Ciencias, Universidad de Alicante, 03080-Alicante, Spain. cnajera@ua.es
Retamosa
M de Gracia
Mde G
Sansano
José M
JM