title: Sch 213766, a novel chemokine receptor CCR-5 inhibitor from Chaetomium globosum.
abstract: A novel fungal secondary metabolite, Sch 213766 was isolated from the fungal fermentation broth of Chaetomium globosum as the chemokine receptor CCR-5 inhibitor and shown to be the methyl ester of the previously described tetramic acid Sch 210972 on the basis of UV, MS and NMR spectral data analyses. Sch213766 exhibited an IC(50) value of 8.6 muM in the CCR-5 receptor in vitro binding assay.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. shu-wei.yang@spcorp.com
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Yang
authors.forename: Ronald
authors.initials: R
authors.lastname: Mierzwa
authors.forename: Joseph
authors.initials: J
authors.lastname: Terracciano
authors.forename: Mahesh
authors.initials: M
authors.lastname: Patel
authors.forename: Vincent
authors.initials: V
authors.lastname: Gullo
authors.forename: Nicole
authors.initials: N
authors.lastname: Wagner
authors.forename: Bahige
authors.initials: B
authors.lastname: Baroudy
authors.forename: Mohindar
authors.initials: M
authors.lastname: Puar
authors.forename: Tze-Ming
authors.initials: TM
authors.lastname: Chan
authors.forename: Min
authors.initials: M
authors.lastname: Chu
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D065100:CCR5 Receptor Antagonists; D002597:Chaetomium / Q000254:growth & development / Q000378:metabolism*; D017077:Culture Media, Conditioned / Q000378:metabolism; D005285:Fermentation; D008738:Methyl Ethers / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology