title: Production of a novel neuromelanin at the sevoflurane-water interface.
abstract: Postoperative cognitive dysfunction (POCD) occurs in the elderly following surgery that requires inhaled anesthetics. The molecular mechanism associated with this process is unknown. This study examined the possible role of serotonin, a neurotransmitter involved in cognition. We observed that sevoflurane, a common inhaled anesthetic, formed a separate phase in water similar to that of chloroform. Additionally, sevoflurane sequestered acrolein, which is a lipid peroxidation product associated with aging and is elevated in the elderly brain. The enhanced partitioning of acrolein increased the focal concentration and hence reactivity to serotonin which preferentially occurred at the sevoflurane-water interface. The resulting product exhibited unique properties similar to catecholamine-derived neuromelanin.
authors.affiliation: Department of Anesthesiology, University of Missouri--Kansas City School of Medicine, 4401 Wornall Road, Kansas City, MO, USA.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Roberts
authors.forename: Eugene E
authors.initials: EE
authors.lastname: Fibuch
authors.forename: M
authors.initials: M
authors.lastname: Elisabeth Heal
authors.forename: Norbert W
authors.initials: NW
authors.lastname: Seidler
mesh_terms: D000171:Acrolein / Q000737:chemistry*; D008543:Melanins / Q000138:chemical synthesis*; D008738:Methyl Ethers / Q000737:chemistry*; D044367:Phase Transition; D012701:Serotonin / Q000737:chemistry*; D000077149:Sevoflurane; D012995:Solubility; D013499:Surface Properties; D014867:Water / Q000737:chemistry*