title: The influence of maternal cigarette smoking on placental pathology in pregnancies complicated by abruption.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effect of maternal cigarette smoking on placental histology in women with abruption.
  
  
  METHODS
  Data were derived from the New Jersey-Placental Abruption Study (NJ-PAS)--an ongoing, case-control study, conducted since August 2002 in 2 large hospitals in NJ. Abruption cases were identified based on a clinical diagnosis. Histologic evaluations were performed by 2 perinatal pathologists who were blinded to the abruption status. Maternal smoking during pregnancy was determined based on patient's self-report. Among abruption cases, histologic findings were compared between smokers and nonsmokers, and the association expressed as odds ratio (OR) with 95% confidence interval (CI). All analyses were adjusted for potential confounders.
  
  
  RESULTS
  A total of 189 abruption cases were available for analysis, of which 10.6% (n = 20) were smokers. Intervillous thrombus was more common in women who smoked (20%) than in nonsmokers (3.0%) (OR, 17.5; 95% CI, 3.1-99.4). However, placental infarcts were seen less frequently among smokers than nonsmokers (10.0% vs 32.5%; OR, 0.2; 95% CI, 0.1-0.8).
  
  
  CONCLUSIONS
  These findings suggest that different pathologic mechanisms may be responsible for the histologic findings between smokers and nonsmokers diagnosed with placental abruption.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
authors.forename: Lilian M
authors.initials: LM
authors.lastname: Kaminsky
authors.forename: Cande V
authors.initials: CV
authors.lastname: Ananth
authors.forename: Vinay
authors.initials: V
authors.lastname: Prasad
authors.forename: Carl
authors.initials: C
authors.lastname: Nath
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Vintzileos
mesh_terms: D000037:Abruptio Placentae / Q000209:etiology / Q000473:pathology*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D049188:Prenatal Injuries / Q000209:etiology*; D012907:Smoking / Q000009:adverse effects*