Molecular microscopy: fundamental limitations.
On the basis of estimates of molecular damage caused by the observation process, it is concluded that molecular microscopy of biological molecules in which the individual atoms are resolved is impossible with an electron or x-ray microscope. Microscopes that use low-energy helium atoms or neutrons as illuminants may be capable of serving as ultimate biomolecular microscopes.
Breedlove
J R
JR
Trammell
G T
GT