Syntheses and structures of organic-inorganic hybrid compounds based on metal-fluconazole coordination polymers and the beta-Mo8O26 anion.
Five organic-inorganic hybrid compounds, namely, [Co2(fcz)4(H2O)4][beta-Mo8O26].5H2O (1), [Ni2(fcz)4(H2O)4][beta-Mo8O26].5H2O (2), [Zn2(fcz)4(beta-Mo8O26)].4H2O (3), [Cu2(fcz)4(beta-Mo8O26)].4H2O (4), and [Ag4(fcz)4(beta-Mo8O26)] (5), where fcz is fluconazole [2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol], were synthesized under hydrothermal conditions, and crystal structures of 1-5 have been determined by X-ray diffraction. In compounds 1 and 2, metal cations are linked by fluconazole ligands to form hinged chain structures and [beta-Mo8O26]4- anions act as counterions. In compound 3, Zn(II) cations are bridged by fluconazole ligands to form 2D (4,4) networks, and each pair of these networks is linked by [beta-Mo8O26]4- anions to form a sandwich double-layer structure. In compound 4, Cu(II) cations are bridged by fluconazole ligands to form 2D (4,4) networks, and these networks are connected by [beta-Mo8O26]4- anions to form a 3D framework. In compound 5, AgI cations and [Ag2]2+ units are bridged by fluconazole ligands to form 2D Ag-fcz layers, and these layers are further connected by [beta-Mo8O26]4- anions to form a complicated 3D structure with the topology of (7(2).8(1))2(7(3).8(3))(7(2).8(11).10(1).12(1))2. Thermogravimetric analyses for these compounds are also discussed in detail. The complexes exhibit antitumor activity in vitro, as shown by MTT experiments.
Li
Shun-Li
SL
Key Lab of Polyoxometalate Science, Department of Chemistry, Northeast Normal University, Changchun 130024, People's Republic of China.
Lan
Ya-Qian
YQ
Ma
Jian-Fang
JF
Yang
Jin
J
Wang
Xiao-Hong
XH
Su
Zhong-Min
ZM
D000838:Anions; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D015725:Fluconazole / Q000737:chemistry*; D006801:Humans; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction