title: Genetics of psoriasis and psoriatic arthritis.
abstract: Psoriasis and psoriatic arthritis are linked diseases characterised by (distinct ?) immune-mediated pathogenetic mechanisms and by a genetic background interacting with environmental factors. Some candidate susceptibility genes have been studied extensively; they include HLA genes, genes within the HLA region and genes outside the HLA region; among them corneodesmosin and other genes of PSORS1 region, MICA and TNF-a polymorphisms. The main findings in the literature are discussed.
authors.affiliation: Rheumatology Unit, University of Cagliari, Monserrato, Cagliari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Mathieu
authors.forename: A
authors.initials: A
authors.lastname: Cauli
authors.forename: A
authors.initials: A
authors.lastname: Vacca
authors.forename: A
authors.initials: A
authors.lastname: Mameli
authors.forename: G
authors.initials: G
authors.lastname: Passiu
authors.forename: G
authors.initials: G
authors.lastname: Porru
authors.forename: M
authors.initials: M
authors.lastname: Piga
authors.forename: V
authors.initials: V
authors.lastname: Ibba
authors.forename: V
authors.initials: V
authors.lastname: Mura
authors.forename: S
authors.initials: S
authors.lastname: Sanna
mesh_terms: D000483:Alleles; D015535:Arthritis, Psoriatic / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics