Sinonasal carcinoma after irradiation for medulloblastoma in nevoid basal cell carcinoma syndrome.
BACKGROUND
Nevoid basal cell carcinoma syndrome (NBCCS) is associated with multiple basal cell carcinomas, odontogenic cysts, craniofacial anomalies, and childhood medulloblastomas. In addition, it has been associated with irradiation-induced neoplasms including, meningiomas, sarcomas, and gliomas.


METHODS
We present a 19-year-old man with NBCCS who presented with a sinonasal carcinoma 17 years after receiving craniospinal irradiation for treatment of medulloblastoma.


RESULTS
To our knowledge, this is the first report of a sinonasal tumor after irradiation in a patient with NBCCS.


CONCLUSIONS
With this case, the authors examine the genotype of NBCCS patients and their propensity for radiation-induced tumors. In addition, the management of neoplasms in these tumor-sensitive patients is reviewed.
Wallin
Jordan L
JL
The George Washington University School of Medicine, Washington DC, USA.
Tanna
Neil
N
Misra
Sasmita
S
Puri
Puja K
PK
Sadeghi
Nader
N
D000328:Adult; D001478:Basal Cell Nevus Syndrome / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000601:surgery*; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects*