Pharmacologic induction of heme oxygenase-1.
Heme oxygenase-1 (HO-1) is a cytoprotective protein whose expression is consistently associated with therapeutic benefits in a number of pathologic conditions such as atherosclerotic vascular disease and inflammation. Although the expression of HO-1 in most tissues is low, a large number of clinical and experimental pharmacologic compounds have been demonstrated to induce HO-1. This induction is suggested to be at least partially responsible for the perceived therapeutic efficacy of these compounds. The increase in HO-1 expression in response to these compounds is the result of a complex regulatory network involving many signaling pathways and transcription factors. Understanding both the pathways by which HO-1 is induced and the mechanism through which the enzyme exerts its beneficial effects may facilitate the development of novel drugs.
Li
Cheng
C
Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Australia.
Hossieny
Parastu
P
Wu
Ben J
BJ
Qawasmeh
Abdelqader
A
Beck
Konstanze
K
Stocker
Roland
R
D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects / Q000502:physiology; D015971:Gene Expression Regulation, Enzymologic; D051547:Heme Oxygenase-1 / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008954:Models, Biological; D009569:Nitric Oxide / Q000494:pharmacology*; D011341:Probucol / Q000494:pharmacology*; D015398:Signal Transduction; D014157:Transcription Factors