title: Multifocal hyperfunctioning thyroid carcinoma without metastases.
abstract: Hyperthyroidism due to thyroid carcinoma is rare, and most cases are caused by hyperfunctioning metastatic thyroid carcinoma rather than primary carcinoma. Among primary hyperfunctioning thyroid carcinoma, multifocal thyroid carcinoma is exceedingly rare, with the only one case being reported in the literature. Here, we describe the case of a 62-year-old woman with multifocal functioning thyroid carcinoma. Technetium-99m (99m Tc) scintigraphic imaging showed four hot areas in the thyroid gland. Histopathological examination of all four nodules revealed papillary carcinoma, corresponding to hot areas in the 99m Tc scintigram. DNA sequencing of the thyrotropin receptor (TSH-R) gene from all nodules revealed no mutation, indicating that activation of TSH-R was unlikely in the pathophysiogenesis of hyperfunctioning thyroid carcinoma in the present case.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan. a-nishida@kitano-hp.or.jp
authors.forename: Akiko T
authors.initials: AT
authors.lastname: Nishida
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hirano
authors.forename: Ryo
authors.initials: R
authors.lastname: Asato
authors.forename: Shinzo
authors.initials: S
authors.lastname: Tanaka
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Kitani
authors.forename: Nobumitsu
authors.initials: N
authors.lastname: Honda
authors.forename: Nobuya
authors.initials: N
authors.lastname: Fujiki
authors.forename: Kouji
authors.initials: K
authors.lastname: Miyata
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Fukushima
authors.forename: Juichi
authors.initials: J
authors.lastname: Ito
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011877:Radionuclide Imaging; D013667:Technetium; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016606:Thyroid Nodule / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography