The allosteric modulation of lipases and its possible biological relevance.
BACKGROUND
During the development of an enantioselective synthesis using the lipase from Mucor miehei an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown.


BACKGROUND
Considering the biological relevance of the discovered regulation mechanism we developed a theory that describes the regulation of energy homeostasis and fat metabolism.


CONCLUSIONS
This theory represents a new approach to explain the cause of the metabolic syndrome and provides an innovative basis for further research activity.
Köhler
Jens
J
Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Hittorfstrasse 58-62, D-48149 Münster, Germany. jenskoeh@uni-muenster.de
Wünsch
Bernhard
B
D000273:Adipose Tissue / Q000378:metabolism; D000494:Allosteric Regulation; D000818:Animals; D016956:Burkholderia cepacia / Q000201:enzymology*; D003198:Computer Simulation; D004734:Energy Metabolism; D006801:Humans; D008049:Lipase / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000145:classification / Q000502:physiology; D024821:Metabolic Syndrome / Q000209:etiology; D009089:Mucor / Q000201:enzymology*; D011487:Protein Conformation; D013559:Symbiosis