title: Biology of dendritic cells in aging.
abstract: Dendritic cells are central to the generation of both immunity and tolerance. This review focuses on the alterations in the functions of dendritic cells in aged and its consequences on both tolerance and immunity. We have discussed certain mechanisms responsible for the defective dendritic cell function associated with aging.
authors.affiliation: Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA. aagrawal@uci.edu
authors.forename: Anshu
authors.initials: A
authors.lastname: Agrawal
authors.forename: Sudhanshu
authors.initials: S
authors.lastname: Agrawal
authors.forename: Jia
authors.initials: J
authors.lastname: Tay
authors.forename: Sudhir
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000276:immunology; D016922:Cellular Senescence / Q000276:immunology*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D007113:Immunity, Innate; D011494:Protein Kinases / Q000378:metabolism