Quality of life in uncomplicated symptomatic diverticular disease: is it another good reason for treatment?
BACKGROUND
Quality of life (QoL) is becoming a major issue in the evaluation of any therapeutic intervention.


OBJECTIVE
To assess the QoL in patients with uncomplicated symptomatic diverticular disease (DD) and to elucidate the influence of two different treatments either on symptoms or QoL.


METHODS
58 outpatients affected by uncomplicated symptomatic DD, admitted in our Gastroenterological Unit from October 2003 to March 2004, were enrolled. Patients were randomly assigned to two different treatments consisting of rifaximin or mesalazine for 10 days every month for a period of 6 months. QoL was evaluated by means of an SF-36 questionnaire and clinical evaluation was registered by means of a global symptomatic score (GSS) at baseline and after 6 months.


RESULTS
At baseline, lower values in all SF-36 domains were confirmed in patients with DD. Both rifaximin and mesalazine groups showed a significant reduction of their mean GSS (p < 0.01 and p < 0.001, respectively) and improvement of SF-36 mean scores after therapy, even though treatment with mesalazine showed better results.


CONCLUSIONS
DD has a negative impact on QoL. Cyclic treatment with poorly absorbable antibiotics or anti-inflammatory drugs relieves symptoms and improves QoL.
Comparato
Giuseppe
G
University of Parma, Parma, Italy.
Fanigliulo
Libera
L
Aragona
Giovanni
G
Cavestro
Giulia M
GM
Cavallaro
Lucas G
LG
Leandro
Gioacchino
G
Pilotto
Alberto
A
Nervi
Giorgio
G
Soliani
Paolo
P
Sianesi
Mario
M
Franzé
Angelo
A
Di Mario
Francesco
F
D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D043963:Diverticulosis, Colonic / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000008:administration & dosage*; D008875:Middle Aged; D011788:Quality of Life; D012294:Rifamycins / Q000008:administration & dosage*; D000078262:Rifaximin; D011795:Surveys and Questionnaires