title: Antileishmanial polyphenols from Garcinia vieillardii.
abstract: Seven xanthones, the new vieillardiixanthones B and C (1) and (7), pancixanthones A (2), B (3), 1,6-dihydroxyxanthone (6), pyranojacareubin and 5,6-O-dimethyl-2-deprenylrheediaxanthone together with two benzophenones, clusiachromene (4) and 3-geranyl-2,4,6-trihydroxybenzophenone (5) were isolated from the stem bark of the neocaledonian Garcinia vieillardii. 2, 5 and 6 showed a significant antileishmanial activity against the promastigote forms of Leishmania mexicana and L. infantum and against the amastigote forms of L. infantum.
authors.affiliation: SONAS, UFR des Sciences Pharmaceutiques et d'Ingénierie de la Santé, 16 Bd Daviers, 49100 Angers, France. anne-emmanuelle.hay@pharm.unige.ch
authors.forename: Anne-Emmanuelle
authors.initials: AE
authors.lastname: Hay
authors.forename: Joumaa
authors.initials: J
authors.lastname: Merza
authors.forename: Anne
authors.initials: A
authors.lastname: Landreau
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Fabrice
authors.initials: F
authors.lastname: Pagniez
authors.forename: Patrice
authors.initials: P
authors.lastname: Le Pape
authors.forename: Pascal
authors.initials: P
authors.lastname: Richomme
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029760:Garcinia / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*