Mimotope vaccines: epitope mimics induce anti-cancer antibodies.
Mimotopes are epitope-mimicking structures. When applied for immunizations they induce desired antibody specificities exclusively based on the principle of molecular mimicry. This is important as antibodies directed against tumor-associated antigens may harbor diverse biological effects depending on their epitope specificity. Thus they may inhibit or promote tumor growth. This review gives an update on different vaccination strategies based on the mimotope concept.
Riemer
Angelika B
AB
Department of Dermatology, Medical University Vienna, Austria.
Jensen-Jarolim
Erika
E
D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis*; D000951:Antigens, Neoplasm / Q000008:administration & dosage / Q000276:immunology*; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000276:immunology*; D000939:Epitopes / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D018716:Molecular Mimicry / Q000276:immunology*