title: Cytotoxicity of triterpenes isolated from Aceriphyllum rossii.
abstract: Bioassay-guided fractionation of a MeOH extract of the whole plant of Aceriphyllum rossii (Saxifragaceae) led to the isolation of two new triterpenes, 3alpha,23-isopropylidenedioxyolean-12-en-27-oic acid (1) and 23-hydroxy-3-oxoolean-12-en-27-oic acid (2), together with six known triterpenes, 3-oxoolean-12-en-27-oic acid (3), 3alpha-hydroxyolean-12-en-27-oic acid (4), beta-peltoboykinolic acid (5), aceriphyllic acid A (6), oleanolic acid (7), and gypsogenic acid (8). The structures of these compounds were elucidated on the basis of physicochemical and spectroscopic analyses. These compounds were evaluated for in vitro cytotoxicity against the K562 and HL-60 cell lines. Olean-12-en-27-oic acid derivatives (1-6) exhibited considerable cytotoxicity against K562 and HL-60 cell lines with IC(50) values ranging from 12.2 to 28.7 microM and from 12.1 to 25.8 microM, respectively.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, Korea.
authors.forename: Iksoo
authors.initials: I
authors.lastname: Lee
authors.forename: Jae Kuk
authors.initials: JK
authors.lastname: Yoo
authors.forename: MinKyun
authors.initials: M
authors.lastname: Na
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
authors.forename: Jongpill
authors.initials: J
authors.lastname: Lee
authors.forename: Bong Sik
authors.initials: BS
authors.lastname: Yun
authors.forename: Wenyi
authors.initials: W
authors.lastname: Jin
authors.forename: Hongjin
authors.initials: H
authors.lastname: Kim
authors.forename: Uijung
authors.initials: U
authors.lastname: Youn
authors.forename: Quan Cheng
authors.initials: QC
authors.lastname: Chen
authors.forename: Kyung Sik
authors.initials: KS
authors.lastname: Song
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Seong
authors.forename: Kihwan
authors.initials: K
authors.lastname: Bae
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000633:toxicity*; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D031995:Saxifragaceae / Q000737:chemistry*; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles; D014315:Triterpenes / Q000302:isolation & purification / Q000633:toxicity*