The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2.
Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2.
Lolkema
Martijn P
MP
Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, rm F02.126, 3584 CX Utrecht, The Netherlands.
Mans
Dorus A
DA
Snijckers
Cristel M
CM
van Noort
Mascha
M
van Beest
Moniek
M
Voest
Emile E
EE
Giles
Rachel H
RH
D000483:Alleles; D000818:Animals; D002460:Cell Line; D006801:Humans; D016547:Kinesins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008870:Microtubules / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D011485:Protein Binding; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics / Q000378:metabolism*