Dependent component analysis for the magnetogastrographic detection of human electrical response activity.
The detection of the basic electric rhythm (BER), composed of a 3 cycles min(-1) oscillation, can be performed using SQUID magnetometers. However, the electric response activity (ERA), which is generated when the stomach is performing a mechanical activity, was detected mainly by invasive electrical measurements and only recently was one report published describing its detection by magnetic measurements. This study was performed with the aim of detecting the ERA noninvasively after a meal. MGG recordings were made with a 74-channel first-order gradiometer (Magnes II, biomagnetic technologies) housed in a shielded room. Seven nonsymptomatic volunteers were measured in the study. Initially a 10 min recording was performed with the subject in the fasted state. A 250 kcal meal was given to the subject without moving out of the magnetometers and two epochs of 10 min each were acquired. The signals were processed to remove cardiac interference by an algorithm based on a variation of independent component analysis (ICA), then autoregressive and wavelet analysis was performed. Preliminary results have shown that there is an increase in the signal power at higher frequencies around (0.6 Hz-1.3 Hz) usually associated with the basic electric rhythm. The center of the frequency band and its width varied from subject to subject, demonstrating the importance of pre-prandial acquisition as a control. Another interesting finding was an increase in power after about 5 min of meal ingestion. This period roughly agrees with the lag phase of gastric emptying, measured by scintigraphy and other techniques. We confirm that MGG can detect the electric response activity in normal volunteers. Further improvements in signal processing and standardization of signal acquisition are necessary to ascertain its possible use in clinical situations.
Estombelo-Montesco
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Department of Physics and Mathematics, FFCLRP, University of São Paulo, 14040-901 Ribeirão Preto, SP, Brazil.
de Araujo
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Silva Filho
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Moraes
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Barros
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Wakai
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Baffa
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D000200:Action Potentials / Q000502:physiology*; D000465:Algorithms; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004594:Electrophysiology / Q000379:methods*; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D008280:Magnetics; D008954:Models, Biological; D009130:Muscle, Smooth / Q000502:physiology; D025341:Principal Component Analysis; D013270:Stomach / Q000502:physiology*