Association of a CYP17 polymorphism with overall survival in Caucasian patients with androgen-independent prostate cancer.
OBJECTIVE
To investigate the association between a cytochrome P450 17alpha-hydroxylase gene (CYP17) polymorphism and survival in Caucasian patients with androgen-independent prostate cancer (AIPC).


METHODS
The study used 222 samples acquired from Caucasian patients with AIPC. The CYP17 polymorphism (-34T>C) was analyzed using polymerase chain reaction amplification followed by restriction fragment length polymorphism detection.


RESULTS
No significant differences were observed in the frequencies of the CYP17 genotype in relation to categorized Gleason scores, age at diagnosis, or hormone therapy. The median survival was significantly longer in 126 patients with the CYP17 A2 allele (8.9 years) genotype than in 96 patients with the A1 allele (6.7 years) genotype (P = 0.040 by log-rank test). Similarly, the estimated survival probability at 10 years (24% in A1 allele versus 43% in A2 allele) showed a statistically significant difference between the two groups (P = 0.002 by the permutation test).


CONCLUSIONS
These results suggest that the CYP17 polymorphism is associated with overall survival in patients with AIPC.
Hamada
Akinobu
A
Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Danesi
Romano
R
Price
Douglas K
DK
Sissung
Tristan
T
Chau
Cindy
C
Venzon
David
D
Sparreboom
Alex
A
Dahut
William L
WL
Figg
William D
WD
D000368:Aged; D000728:Androgens; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000401:mortality*; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*; D015996:Survival Rate; D044465:White People / Q000235:genetics*