title: The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2.
abstract: Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2.
authors.affiliation: Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, rm F02.126, 3584 CX Utrecht, The Netherlands.
authors.forename: Martijn P
authors.initials: MP
authors.lastname: Lolkema
authors.forename: Dorus A
authors.initials: DA
authors.lastname: Mans
authors.forename: Cristel M
authors.initials: CM
authors.lastname: Snijckers
authors.forename: Mascha
authors.initials: M
authors.lastname: van Noort
authors.forename: Moniek
authors.initials: M
authors.lastname: van Beest
authors.forename: Emile E
authors.initials: EE
authors.lastname: Voest
authors.forename: Rachel H
authors.initials: RH
authors.lastname: Giles
mesh_terms: D000483:Alleles; D000818:Animals; D002460:Cell Line; D006801:Humans; D016547:Kinesins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008870:Microtubules / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D011485:Protein Binding; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics / Q000378:metabolism*