The deoxycytidine pathway for thymidylate synthesis in Escherichia coli.
When thymidylate production is diminished by a mutation affecting dCTP deaminase, Escherichia coli is known to use an alternate pathway involving deoxycytidine as an intermediate. The pathway requires the gene for any of three nucleoside diphosphate kinases (ndk, pykA, or pykF) and the gene for a 5'-nucleotidase (yfbR).
Weiss
Bernard
B
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Whitehead Bldg., Rm. 141, 615 Michael St., Atlanta, GA 30322, USA. bweiss2@emory.edu
D003841:Deoxycytidine / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D005838:Genotype; D007700:Kinetics; D010957:Plasmids; D013938:Thymidine Monophosphate / Q000096:biosynthesis*