Comparative interactomics: comparing apples and pears?
The study of the complex web of interactions that link biological molecules in a cell is the subject of interactomics--currently one of the fastest moving fields in molecular biology. The recent completion of high-throughput studies to investigate systematically all the possible interactions in a variety of model organisms has provided unique opportunities to compare interaction networks and ask questions about their conservation during evolution. It is expected that this approach will yield a scientific return as rich as that obtained in the past decade from comparing genomes and proteomes from different organisms.
Kiemer
Lars
L
Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, Italy.
Cesareni
Gianni
G
D000818:Animals; D019143:Evolution, Molecular; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010944:Plants; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013045:Species Specificity