Inflammatory pseudotumors of the pancreas and liver with infiltration of IgG4-positive plasma cells.
Recently, it has been reported that autoimmune pancreatitis (AIP) can be complicated with various extrapancreatic lesions. Here, we report a very rare case of pancreatic and hepatic inflammatory pseudotumor (IPT) with the infiltration of IgG4-positive plasmacytes. The patient showed pancreatic and hepatic masses with elevated levels of serum IgG4. Endoscopic retrograde cholangiopancreatography revealed narrowing of the intrapancreatic bile duct. Fluorine-18fluorodeoxyglucose positron emission tomography suggested pancreatic cancer with hepatic metastasis. Histopathologic findings showed fibrosis and infiltration of IgG4-positive plasmacytes, suggesting IPT. The present case suggests a possible common mechanism in the development of AIP and IPT of the liver.
Uchida
Kazushige
K
Third Department of Internal Medicine, Kansai Medical University, Moriguchi. uchidak@hirakata.kmu.ac.jp
Satoi
Sohei
S
Miyoshi
Hideaki
H
Hachimine
Daisaku
D
Ikeura
Tsukasa
T
Shimatani
Masaaki
M
Matsushita
Mitsunobu
M
Takaoka
Makoto
M
Takai
Soichiro
S
Ashida
Kiyoshi
K
Okazaki
Kazuichi
K
D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology; D006104:Granuloma, Plasma Cell / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008107:Liver Diseases / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000175:diagnosis* / Q000276:immunology; D010195:Pancreatitis / Q000175:diagnosis / Q000276:immunology; D010950:Plasma Cells / Q000473:pathology*; D012075:Remission, Spontaneous