title: A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder.
abstract: Lithium is one of the most commonly used drugs for the treatment of bipolar disorder. To prescribe lithium appropriately to patients, predictors of response to this drug were explored, and several genetic markers are considered to be good candidates. We previously reported a significant association between genetic variations in the breakpoint cluster region (BCR) gene and bipolar disorder. In this study, we examined a possible relationship between response to maintenance treatment of lithium and Asn796Ser single-nucleotide polymorphism in the BCR gene. Genotyping was performed in 161 bipolar patients who had been taking lithium for at least 1 year, and they were classified into responders for lithium mono-therapy and non-responders. We found that the allele frequency of Ser796 was significantly higher in non-responders than in responders. Further investigation is warranted to confirm our findings.
authors.affiliation: Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Hokkaido, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Masui
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kusumi
authors.forename: Katsuji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Teruaki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Shin
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Tatsuyo
authors.initials: T
authors.lastname: Suzuki
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kunugi
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Koyama
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D018692:Antimanic Agents / Q000627:therapeutic use*; D001216:Asparagine / Q000235:genetics; D001714:Bipolar Disorder / Q000145:classification / Q000235:genetics* / Q000517:prevention & control*; D010054:Brief Psychiatric Rating Scale; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D018020:Lithium Compounds / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense / Q000235:genetics*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051562:Proto-Oncogene Proteins c-bcr / Q000235:genetics*; D012694:Serine / Q000235:genetics