title: Sinonasal carcinoma after irradiation for medulloblastoma in nevoid basal cell carcinoma syndrome.
abstract: BACKGROUND
  Nevoid basal cell carcinoma syndrome (NBCCS) is associated with multiple basal cell carcinomas, odontogenic cysts, craniofacial anomalies, and childhood medulloblastomas. In addition, it has been associated with irradiation-induced neoplasms including, meningiomas, sarcomas, and gliomas.
  
  
  METHODS
  We present a 19-year-old man with NBCCS who presented with a sinonasal carcinoma 17 years after receiving craniospinal irradiation for treatment of medulloblastoma.
  
  
  RESULTS
  To our knowledge, this is the first report of a sinonasal tumor after irradiation in a patient with NBCCS.
  
  
  CONCLUSIONS
  With this case, the authors examine the genotype of NBCCS patients and their propensity for radiation-induced tumors. In addition, the management of neoplasms in these tumor-sensitive patients is reviewed.
authors.affiliation: The George Washington University School of Medicine, Washington DC, USA.
authors.forename: Jordan L
authors.initials: JL
authors.lastname: Wallin
authors.forename: Neil
authors.initials: N
authors.lastname: Tanna
authors.forename: Sasmita
authors.initials: S
authors.lastname: Misra
authors.forename: Puja K
authors.initials: PK
authors.lastname: Puri
authors.forename: Nader
authors.initials: N
authors.lastname: Sadeghi
mesh_terms: D000328:Adult; D001478:Basal Cell Nevus Syndrome / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000601:surgery*; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects*