ORAL ADMINISTRATION OF PENICILLIN.
A convenient, practical and effective procedure of administering penicillin by mouth consists of mixing the drug with one tablespoonful of aluminum hydroxide. Substantially higher blood levels are obtained following a 50,000 and a 100,000 unit dose of penicillin with this method than after administration of the drug dissolved in water, either with or without previous ingestion of a mild antacid, such as aluminum hydroxide. Adsorption of penicillin on aluminum hydroxide appears to exert a local protective effect against that portion of gastric acid with which it comes into contact.
Barach
A L
AL
Garthwaite
B
B
Oppenheimer
E T
ET
Forman
J
J
Osburg
H
H