title: Generalized lichen nitidus with involvement of the palms following interferon alpha treatment.
abstract: Lichen nitidus is an uncommon dermatosis of unknown etiology. Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin. Furthermore in our patient we could show a strong lesional expression of MxA, a protein specifically induced by type I interferon. It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus.
authors.affiliation: Department of Dermatology, University of Bonn, Bonn, Germany. marina.scheler@ukb.uni-bonn.de
authors.forename: Marina
authors.initials: M
authors.lastname: Scheler
authors.forename: Julia
authors.initials: J
authors.lastname: Proelss
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Bräuninger
authors.forename: Thomas
authors.initials: T
authors.lastname: Bieber
authors.forename: Joerg
authors.initials: J
authors.lastname: Wenzel
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects*; D005260:Female; D006225:Hand; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D017513:Lichen Nitidus / Q000139:chemically induced / Q000209:etiology*; D008875:Middle Aged; D012254:Ribavirin / Q000009:adverse effects