title: Gastric pleomorphic leiomyosarcoma in a Shetland sheepdog.
abstract: A solitary mass of 6 x 6 x 5 cm was found in the smooth muscle layer of the pyloric part in the stomach of a Shetland sheepdog. The excised mass was solid, gray-white in color, and had central necrosis with hemorrhages. Microscopically, the neoplasm was composed of irregular bundles of spindle-shaped tumor cells and round tumor cells. A few multinucleated cells and gangliocyte-like cells were observed. The nuclei exhibited a high degree of atypia and many cells contained mitotic figures. Immunohistochemically, tumor cells were positive for vimentin and desmin, but negative for c-kit antibody. Ultrastructurally, tumor cells contained cytoplasmic myofilaments and pinocytotic vesicles. Based on these pathological findings, the tumor was diagnosed as gastric pleomorphic leiomyosarcoma.
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Amori, Japan.
authors.forename: Chun-Ho
authors.initials: CH
authors.lastname: Park
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Ishizuka
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tsuchida
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Oyamada
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000473:pathology*; D004285:Dogs; D005260:Female; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*