[Correlation of the polymorphism of HLA-A, B and DRB1 alleles with nasopharyngeal carcinoma in the south of China].
OBJECTIVE
To explore the correlation between and nasopharyngeal carcinoma the polymorphism of HLA-A, B and DRB1 alleles in the south of China.


METHODS
The genotypes of HLA-A, B and DRB1 alleles in 35 patients with NPC and 60 healthy controls were determined by PCR-sequence-specific primer (PCR-SSP).


RESULTS
The frequency of HLA-A * 02, HLA-B * 58 and HLA-DRB1 * 03 in the patients with NPC was higher than that in healthy controls (P < 0.05) while the frequency of HLAB * 40 was lower than that in NPC patients (P<0.05).


CONCLUSIONS
HLA-A * 02, HLA-B * 58 and HLA-DRB1 * 03 might be the susceptible genes of NPC patients while HLA-B * 40 might be the protective gene of NPC patients.
Zeng
Xue-hui
XH
Institute of Cellular and Molecular Medicine, Key Laboratory of Medical Genetics of Zhejiang Provincial, Wenzhou Medical College, Wenzhou 325035, China. zxh419@163.com
Xiao
Lu-lu
LL
Li
Jiang
J
Lu
Jian-xin
JX
Wang
Xiao-ning
XN
D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics*; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic