title: The proinflammatory cytokines TNF-alpha and IL-1 beta impair economy of contraction in human myocardium.
abstract: Considerable experimental evidence has accumulated over the past years that proinflammatory cytokines, especially TNF-alpha and IL-1beta, impair myocardial function in different animal species. On the other hand, several prospective clinical trials studying TNF-alpha antagonist in patients with chronic heart failure were not able to demonstrate a benefit. As there might be a relevant species-related discrepancy, we intended to prove our previous results demonstrating impaired myocardial economy after exogenous administration of recombinant TNF-alpha in rat myocardium. In the present study, both TNF-alpha and IL-1beta not only revealed an immediate negative inotropic effect but also increased specific oxygen demand in human right-atrial myocardium. Enhanced oxygen consumption was not caused by an elevated basal metabolism but an impaired economy of contraction. Our results suggest that proinflammatory cytokines have a considerable effect on myocardial mechano-energetic parameters in human myocardium as well.
authors.affiliation: University of Wurzburg, Medizinische Klinik und Poliklinik I, Abteilung Kardiologie, Germany. hofmann_u2@klinik.uni-wuerzburg.de
authors.forename: U
authors.initials: U
authors.lastname: Hofmann
authors.forename: S
authors.initials: S
authors.lastname: Heuer
authors.forename: K
authors.initials: K
authors.lastname: Meder
authors.forename: J
authors.initials: J
authors.lastname: Boehler
authors.forename: V
authors.initials: V
authors.lastname: Lange
authors.forename: T
authors.initials: T
authors.lastname: Quaschning
authors.forename: G
authors.initials: G
authors.lastname: Ertl
authors.forename: A
authors.initials: A
authors.lastname: Bonz
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000494:pharmacology*; D053583:Interleukin-1beta / Q000494:pharmacology*; D007537:Isometric Contraction / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000276:immunology; D009206:Myocardium / Q000276:immunology / Q000378:metabolism*; D010101:Oxygen Consumption / Q000276:immunology; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*