A new dihydrobenzofuran derivative from the endophytic fungus Botryosphaeria mamane PSU-M76.
One new dihydrobenzofuran derivative, botryomaman (1), was isolated from the broth extract of the endophytic fungus Botryosphaeria mamane PSU-M76 along with six known compounds, 2,4-dimethoxy-6-pentylphenol, (R)-(-)-mellein, primin, cis-4-hydroxymellein, trans-4-hydroxymellein and 4,5-dihydroxy-2-hexenoic acid. The structures were assigned by spectroscopic methods. All compounds were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus SK1. Primin showed the best activity against both strains with equal MIC values of 8 microg/ml.
Pongcharoen
Wipapan
W
Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkla, Thailand.
Rukachaisirikul
Vatcharin
V
Phongpaichit
Souwalak
S
Sakayaroj
Jariya
J
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects