title: Long-term effect of 1-piece and 3-piece hydrophobic acrylic intraocular lens on posterior capsule opacification: a randomized trial.
abstract: OBJECTIVE
  To compare the intensity of posterior capsule opacification (PCO) between the 1-piece and 3-piece haptic designs of the foldable hydrophobic acrylic AcrySof intraocular lens (IOL) over a 5-year period.
  
  
  METHODS
  Randomized, prospective, patient- and examiner-masked clinical trial with intraindividual comparison.
  
  
  METHODS
  Fifty-two patients with bilateral age-related cataract (104 eyes).
  
  
  METHODS
  Each study patient had cataract surgery in both eyes and received a 1-piece AcrySof IOL in 1 eye and a 3-piece AcrySof IOL in the other eye. Follow-up examinations were performed at 1 week, 1 month, 6 months, and 1, 2, and 5 years. Digital retroillumination images were obtained of each eye. The amount of posterior capsule opacification (score range, 0-10) was assessed subjectively at the slit lamp and objectively using automated image analysis software 1, 2, and 5 years after surgery.
  
  
  METHODS
  Posterior capsule opacification score (scale, 0-10).
  
  
  RESULTS
  There was no significant difference between the 1-piece and 3-piece AcrySof IOL in best-corrected visual acuity, overlap of rhexis and IOL, capsular folds, anterior capsule opacification, and posterior capsule opacification (1-piece AcrySof PCO score, 1.7+/-1.7; 3-piece AcrySof PCO score, 1.3+/-1.4; P = 0.30).
  
  
  CONCLUSIONS
  Modification of the IOL haptic design of the sharp optic edged AcrySof IOL from a 3-piece to a 1-piece haptic design caused no significant change in PCO intensity and neodymium:yttrium-aluminium-garnet laser treatment rate 5 years after surgery.
authors.affiliation: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. christina.leydolt@meduniwien.ac.at
authors.forename: Christina
authors.initials: C
authors.lastname: Leydolt
authors.forename: Sofija
authors.initials: S
authors.lastname: Davidovic
authors.forename: Stefan
authors.initials: S
authors.lastname: Sacu
authors.forename: Rupert
authors.initials: R
authors.lastname: Menapace
authors.forename: Thomas
authors.initials: T
authors.lastname: Neumayer
authors.forename: Ana
authors.initials: A
authors.lastname: Prinz
authors.forename: Wolf
authors.initials: W
authors.lastname: Buehl
authors.forename: Oliver
authors.initials: O
authors.lastname: Findl
mesh_terms: D000180:Acrylic Resins; D000368:Aged; D002386:Cataract / Q000209:etiology*; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy; D007903:Lens Capsule, Crystalline / Q000473:pathology* / Q000601:surgery; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D018918:Phacoemulsification; D011183:Postoperative Complications; D011446:Prospective Studies; D011474:Prosthesis Design; D014792:Visual Acuity