Baroreflex dysfunction in rats submitted to protein restriction.
Earlier studies from the authors' laboratory showed that malnourishment induces alterations in the cardiovascular homeostasis increasing the basal mean arterial pressure and heart rate. In this study, the authors evaluated whether the sympathetic and parasympathetic efferent activities contribute to changes in the cardiovascular homeostasis through altered modulation of the arterial baroreflex of malnourished rats. After weaning, male Fischer rats were given 15% (Normal Protein--NP) or 6% (Low Protein--LP) protein diet for 35 d. The baroreflex gain and latency were evaluated before and after selective autonomic blockades in control and malnourished rats. It was observed that malnourishment affected the baroreflex gain in response to activation and deactivation of the arterial baroreflex. Moreover, malnourished rats showed increased baroreflex latency as compared to that of control rats. Regarding the autonomic efferent activity directed to the heart, the data showed increased sympathetic and decreased parasympathetic efferent activities in malnourished rats, and such alterations could be related to the observed changes in the arterial baroreflex gain as well as in the basal mean arterial pressure and heart rate.
Loss
Igor de O
Ide O
Department of Biological Sciences, DECBI-NUPEB, Federal University of Ouro Preto, 35400-000, Ouro Preto, MG, Brazil.
Fernandes
Luciano G
LG
Martins
Carlito D D
CD
Cardoso
Leonardo M
LM
Silva
Marcelo E
ME
Dias-da-Silva
Valdo J
VJ
Moraes
Márcio F D
MF
Chianca
Deoclécio A
DA
D000818:Animals; D001158:Arteries / Q000473:pathology; D001286:Atropine Derivatives / Q000494:pharmacology*; D017704:Baroreflex / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism; D005786:Gene Expression Regulation; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D011312:Pressure; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344