The hOGG1 Ser326Cys polymorphism is not associated with colorectal cancer risk.
BACKGROUND
Little is known about the genetic risk factors associated with colorectal cancer. Although the Ser326Cys polymorphism of 8-oxoguanine DNA glycosylase (hOGG1) is consistently associated with a range of cancers, there is no consensus regarding this polymorphism and colorectal cancer risk.


METHODS
In the present study, conducted in a Korean population, we used the TaqMan assay to investigate whether the hOGG1 Ser326Cys polymorphism was associated with colorectal cancer in 439 colorectal cancer patients and 676 healthy normal controls. We also examined whether the hOGG1 Ser326Cys polymorphism is associated with tumor location, microsatellite instability (MSI) status and tumor-node-metastasis (TNM) stage in colorectal cancer.


RESULTS
We found no significant difference between the cancer and control populations in terms of genotype distribution (CC, CG and GG). In addition, we found no association between the hOGG1 Ser326Cys polymorphism and cancer risk, MSI status, TNM stage or tumor location in colorectal cancer patients.


CONCLUSIONS
These results suggest that unlike for other cancer types, the hOGG1 Ser326Cys polymorphism is not a major genetic risk factor for colorectal cancer.
Park
Hye-Won
HW
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University, Korea.
Kim
Il-Jin
IJ
Kang
Hio Chung
HC
Jang
Sang-Geun
SG
Ahn
Sun-A
SA
Lee
Jin Soo
JS
Shin
Hai-Rim
HR
Park
Jae-Gahb
JG
D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D045647:DNA Glycosylases / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors