title: [Central venous catheter-related infections: risk factors and effects of glycopeptide antibiotics].
abstract: BACKGROUND
  Central venous catheters (CVC) are used in the treatment of critically ill patients. Indications for placement of CVCs include hemodynamic monitoring, administration of intravenous fluids, medications and total parenteral nutrition.
  
  
  METHODS
  We investigated risk factors and effects of glycopeptide antibiotics on the development of central venous catheter-related injections in 300 patients treated in intensive care units. A semiquntitative culture technique was used. The investigation included: age, diagnosis on admission, catheter insertion site, catheter duration, the first or next catheter and using of glycopeptide drugs.
  
  
  RESULTS
  91 catheters (30.3%) were colonised, catheter-related infection was found in 50 catheters (16.7%). Infections were more frequent in catheters inserted through the internal jugular vein than in subclavian venous catheters, they were also more frequent if duration of catheterization was longer than seven days, but less frequent in patients who received glycopeptide antibiotics. The isolated microorganism was Staphylococcus aureus. Discussion According to the literature, a number of catheter-related risk factors for infections include: insertion site, type of catheter, the number of manipulations, inadequat asepsis, lumen number, type of antiseptic. The relative importance of one risk factor over another is difficult to assess, given that studies have no priority report.
  
  
  CONCLUSIONS
  The duration of catheterization and the insertion site were the most frequent risk factors for infection. The use of glycopeptide antibiotics during catheterization has protective effects.
authors.affiliation: Klinicki centar Srbije, Beograd, Institut za ginekologiju i akuserstvo, Odeljenje anestezije i reanimacije. barsenijevic@Eunet.yu
authors.forename: Ljubica
authors.initials: L
authors.lastname: Arsenijević
authors.forename: Nada
authors.initials: N
authors.lastname: Popović
authors.forename: Zvezdana
authors.initials: Z
authors.lastname: Kojić
authors.forename: Slobodanka
authors.initials: S
authors.lastname: Stefanović
authors.forename: Dejan
authors.initials: D
authors.lastname: Filimonović
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Karamarković
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D006020:Glycopeptides / Q000627:therapeutic use*; D006801:Humans; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides