title: Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan.
abstract: Small molecule agonists and antagonists of the V(2)-vasopressin receptor have been discovered and have undergone clinical trials. In conjunction with these discovery programs, the synthesis and biological testing of various metabolites associated with these clinical targets were actively pursued. We now report the results of our synthetic efforts and the corresponding biological data generated for several of the metabolites of WAY-151932 and CL-347985 (Lixivaptan).
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. Molinaa@wyeth.com
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Molinari
authors.forename: Eugene J
authors.initials: EJ
authors.lastname: Trybulski
authors.forename: Jehan
authors.initials: J
authors.lastname: Bagli
authors.forename: Susan
authors.initials: S
authors.lastname: Croce
authors.forename: John
authors.initials: J
authors.lastname: Considine
authors.forename: Jian
authors.initials: J
authors.lastname: Qi
authors.forename: Kadum
authors.initials: K
authors.lastname: Ali
authors.forename: William
authors.initials: W
authors.lastname: Demaio
authors.forename: Lynne
authors.initials: L
authors.lastname: Lihotz
authors.forename: David
authors.initials: D
authors.lastname: Cochran
mesh_terms: D065092:Antidiuretic Hormone Receptor Antagonists; D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001549:Benzamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001552:Benzazepines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D011758:Pyrroles; D017483:Receptors, Vasopressin / Q000819:agonists*; D001569:Benzodiazepines
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D001381:Azepines; D001549:Benzamides; D001552:Benzazepines; D011758:Pyrroles; D017483:Receptors, Vasopressin; C509746:WAY-151932; C409452:lixivaptan; D001569:Benzodiazepines