Adverse effects of diclofenac sodium on renal parenchyma of adult albino rats.
OBJECTIVE
To see the toxic effects of NSAID on kidney tissue of albino rats.


METHODS
For this experimental study, 16 albino rats were taken. They were divided into two groups; A and B. The animals in group-A were given Normal Saline. Group-B received Diclofenac Sodium 2 mg/kg/day by feeding tube for 14 days. On day-15 all animals were sacrificed. Kidneys were removed, fixed, embedded in paraffin, section cut at 4 microm thick and stained with H&E, PAS, and silver methenamine. Renal histology was done under light microscope to see the renal tubular diameter, count and cellular detail.


RESULTS
The result of present study revealed that diclofenac sodium in single daily dose of 2 mg/kg for a period of two weeks effectively produced destruction of proximal and distal convoluted tubules in adult albino rats showing the dilatation of tubule and flattening of tubular epithelium, disruption of brush border in proximal tubule and thickening of basement membrane around proximal and distal tubular epithelium.


CONCLUSIONS
Diclofenac sodium induced nephrotoxicity causes the destruction of proximal and distal convoluted tubules showing the dilatation of tubule and flattening of its epithelium in albino rats.
Yasmeen
Talat
T
Department of Anatomy, Sindh Medical College, Jinnah Postgraduate Medical Centre, Karachi.
Qureshi
Ghulam Sarwar
GS
Perveen
Sughra
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004008:Diclofenac / Q000009:adverse effects*; D004848:Epithelium / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects*; D007686:Kidney Tubules, Distal / Q000187:drug effects; D007687:Kidney Tubules, Proximal / Q000187:drug effects; D023421:Models, Animal; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac