[Tissue engineering and construction of human skin in vitro].
Tissue engineering is the new science that has come to make possible the growth of new organ tissue from small fragments of healthy tissue, thus partially or totally restoring the lost functions of ill tissues or organs, as shown by the achievements made with the culture of skin, cornea or cartilage. Thus far, this new science is able to ensure the recovery of lost functions and, doubtlessly, in a near future will be capable of developing tissues and organs not unlike natural ones. In our laboratory we have began the development of tissue engineering techniques for the successful construction of in vitro skin with the aim at mid term of producing cornea and cartilage. In a first clinical trial, these techniques were applied in the treatment of chronic skin lesions and the advantages and reach of these new tools were demonstrated for the effective solution of problems with would otherwise not be easily solved through the use of conventional treatments.
Arvelo
Francisco
F
Laboratorio dc Cultivo de Tejidos y Biología de Tumores, Centro de Biología Celular, Instituto de Biología Experimental, Facultad de Ciencias, Universidad Central de Venezuela, Apartado 47114, Caracas 1041A, Venezuela. franarvelo@yahoo.es
D000818:Animals; D002056:Burns / Q000628:therapy; D018929:Cell Culture Techniques; D018920:Coculture Techniques; D004847:Epithelial Cells / Q000166:cytology; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D015603:Keratinocytes / Q000166:cytology; D051379:Mice; D009924:Organ Culture Techniques; D012867:Skin; D012871:Skin Diseases / Q000628:therapy; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends