title: Bioactive p-terphenyl derivatives from a Cordyceps-colonizing isolate of Gliocladium sp.
abstract: Gliocladinins A (1) and B (2), two new p-terphenyl derivatives, have been isolated from solid cultures of an isolate of Gliocladium sp. that colonizes Cordyceps sinensis. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. In standard disk assays, compounds 1 and 2 showed modest antimicrobial activity against Staphylococcus aureus (ATCC 6538). In addition, these compounds displayed inhibitory effects on the growth of two human tumor cell lines, HeLa and HCT116.
authors.affiliation: Key Laboratory of Systemic Mycology and Lichenology, Center for Bio-Energy and Industrial Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Guo
authors.forename: Hejiao
authors.initials: H
authors.lastname: Hu
authors.forename: Shuchun
authors.initials: S
authors.lastname: Liu
authors.forename: Xingzhong
authors.initials: X
authors.lastname: Liu
authors.forename: Yuguang
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032661:Cordyceps; D004354:Drug Screening Assays, Antitumor; D020462:Gliocladium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects*; D013730:Terphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018609:Tibet
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D013730:Terphenyl Compounds; C524247:gliocladinin A; C524248:gliocladinin B