[The state of the art in human dental stem cell research].
This review article arranges the current results of stem cell biology for their use in dentistry. There are different types of stem cells, which are applicable for dental treatments. The use of embryonic stem cells, whose possibilities for breeding an artificial tooth were hardly evaluated, is however ethically precarious. On the other side the ethically harmless adult stem cells, which were isolated for example from bone marrow, were little examined for their capability of differentiation into dental tissues. Therefore their forthcoming use in dentistry is rather improbable. However, dental ectomesenchymal stem cells are more promising for dentistry in future. For example dental pulp stem cells (DPSCs) are capable to differentiate into dentin under in vitro conditions. Moreover it is possible to use periodontal ligament (PDL) stem cells and dental follicle precursors for periodontal tissue differentiations in vitro. Recently new populations of stem cells were isolated from the dental pulp and the PDL. These cells distinguish from the initially isolated DPSCs and PDL stem cells in growth and cell differentiation. Therefore stem cell markers are very important for the characterization of dental stem cells. A significant marker for dental stem cells is STRO-1, which is also a marker for bone marrow derived mesenchymal stem cells. Nonetheless dental stem cells are CD45 negative and they express rarely hematopoietic stem cell markers. These research results plead for the participation of dental stem cells in dental practice in future.
Morsczeck
Christian
C
Institut für Humangenetik, Universität Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany. christian.morsczeck@klinik.uni-regensburg.de
Reichert
Torsten Eugen
TE
Völlner
Florian
F
Gerlach
Till
T
Driemel
Oliver
O
D000954:Antigens, Surface / Q000032:analysis; D002454:Cell Differentiation / Q000502:physiology; D003782:Dental Pulp / Q000166:cytology; D018865:Dental Research / Q000941:ethics / Q000639:trends*; D003795:Dental Sac / Q000166:cytology; D053595:Embryonic Stem Cells / Q000637:transplantation; D004990:Ethics, Dental; D005544:Forecasting; D006801:Humans; D017493:Leukocyte Common Antigens / Q000032:analysis; D045164:Mesenchymal Stem Cell Transplantation / Q000941:ethics / Q000639:trends; D010513:Periodontal Ligament / Q000166:cytology; D033581:Stem Cell Transplantation / Q000941:ethics / Q000639:trends*; D009057:Stomatognathic Diseases / Q000628:therapy*
D000954:Antigens, Surface; C525591:STRO-1 antigen, human; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human