title: Washability and fabric-staining properties of a novel phospholipid-structured coal tar formulation.
abstract: BACKGROUND
  Coal tar is one of the most preferred and frequently used medicinal agents in various dermatological diseases. However, the coal tar formulations available for clinical use suffer from the limitation of staining clothes and skin, eventually leading to a high degree of patient non-compliance.
  
  
  OBJECTIVE
  To test the staining property of a lecithinized formulation vis-a-vis a conventional formulation of coal tar employing different types of fabric.
  
  
  METHODS
  Six fabrics with different blends of cotton and polyester were employed to test the staining and washability of two coal tar formulations following application for 24 hours and 48 hours.
  
  
  RESULTS
  The study revealed the distinct superiority of the lecithinized coal tar formulation vis-a-vis the conventional marketed formulation due to its markedly reduced staining and easier washability. A significant reduction in the staining of fabrics containing polyester was observed with the lecithinized formulation, with the stain becoming progressively worse as the proportion of polyester in the fabric increased. The stains washed off completely with detergent in the case of the lecithinized coal tar formulation, whereas stains from the conventional coal tar formulation remained intact.
  
  
  CONCLUSIONS
  The developed lecithinized formulation, owing to its superior non-staining and washability characteristics, would potentially increase the acceptability of coal tar amongst patients.
authors.affiliation: University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Bhatia
authors.forename: Puneet
authors.initials: P
authors.lastname: Mangat
authors.forename: Bhawana
authors.initials: B
authors.lastname: Jain
authors.forename: Bhupinder
authors.initials: B
authors.lastname: Singh
authors.forename: Om Prakash
authors.initials: OP
authors.lastname: Katare
mesh_terms: D002626:Chemistry, Pharmaceutical; D003020:Clothing; D003033:Coal Tar; D032561:Cotton Fiber; D006801:Humans; D007641:Keratolytic Agents; D054709:Lecithins; D010743:Phospholipids; D011091:Polyesters; D013194:Staining and Labeling; D013501:Surface-Active Agents
chemical_list: D007641:Keratolytic Agents; D054709:Lecithins; D010743:Phospholipids; D011091:Polyesters; D013501:Surface-Active Agents; D003033:Coal Tar