[Study on the efficacy of hepatitis B virus vaccination and its influencing factors among children in rural area of Jiangsu province].
OBJECTIVE
To evaluate the efficacy of hepatitis B viruse (HBV) vaccination and its influencing factors among children in rural area of Jiangsu province.


METHODS
Twenty-five hundred and twenty-two children born after 1998 in rural area were selected as the study population using multistage cluster sampling method. HBsAg and anti-HBs were detected by enzyme linked immunoassay (ELISA) and radio-immunoassay (RIA), respectively. Anti-HBs negative children were boosted using different hepatitis B vaccines and the efficacy was compared. Factors causing HBV infection in HBsAg positive children were also investigated.


RESULTS
HBsAg positive rates in 1-7 year olds were 0.28%-1.28%, and the anti-HBs positive rates decreased from 76.7% to 45.5%. The HBsAg positive rate in children not timely vaccinated was significantly higher than those with HBV vaccine injection within 24 hours after birth (1.4% vs. 0.5%, P = 0.031). More than 90% of the anti-HBs negative children had protective level of anti-HBs after boosted with HBV vaccine.


CONCLUSIONS
HBsAg positive rate in children born after 1998 in rural area of Jiangsu province decreased significantly, with an average of 0.8%. The reason for HBsAg carriage in children might be attributed to mother-to-infant transmission or not timely HBV vaccination.
Zhai
Xiang-jun
XJ
Jiangsu Centers for Disease Control and Prevention, Nanjing 210009, China.
Wang
Hua
H
Zhu
Feng-cai
FC
Yu
Jia-xi
JX
Chen
Yin-zhong
YZ
Qiu
Xiang-peng
XP
Gu
Shan-Kun
SK
Liu
She-lan
SL
Qin
Li-ming
LM
Liang
Zheng-lun
ZL
Zhuang
Hui
H
D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D012424:Rural Population
D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines