Language outcome after perinatal stroke: does side matter?
The goal of this study was to examine structured language skills in children with perinatal strokes. Participants were 28 school-age children with early focal brain lesions (17 with left hemisphere [LH] damage, 11 with right hemisphere [RH] damage), and 57 controls. A standardized test of language (Clinical Evaluation of Language Fundamentals-Revised) was administered. Receptive, Expressive, and Total Language scores, as well as subtest scores, were analyzed. Control participants scored within the normal range, whereas the LH and RH groups scored significantly more poorly than did controls. There were no differences between the LH and RH groups on any of the language scores, and all scores were below the 14th percentile. Within the lesion group as a whole, scores were not related to lesion laterality, site, or severity. Results also were not accounted for by socioeconomic status or IQ. However, children who experienced seizures demonstrated significantly poorer performance than did children who did not experience seizures. Damage to either the LH or RH early in development adversely affects later language abilities, particularly on tasks with structured and complex linguistic demands. Although lesion side has little effect, the presence or absence of seizures is a major contributor to language outcome.
Ballantyne
Angela O
AO
Department of Neuroscience, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. aballant@crl.ucsd.edu
Spilkin
Amy M
AM
Trauner
Doris A
DA
D000293:Adolescent; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003071:Cognition / Q000502:physiology; D003627:Data Interpretation, Statistical; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007361:Intelligence Tests; D007804:Language Development; D007807:Language Tests; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D012640:Seizures / Q000150:complications / Q000503:physiopathology; D020521:Stroke / Q000151:congenital* / Q000473:pathology / Q000523:psychology*; D014825:Vocabulary