title: Comment on "The consensus coding sequences of human breast and colorectal cancers".
abstract: Sjöblom et al. (Research Article, 13 October 2006, p. 268) reported nearly 200 novel cancer genes said to have a 90% probability of being involved in colon or breast cancer. However, their analysis raises two statistical concerns. When these concerns are addressed, few genes with significantly elevated mutation rates remain. Although the biological methodology in Sjöblom et al. is sound, more samples are needed to achieve sufficient power.
authors.affiliation: Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA. gadgetz@broad.mit.edu
authors.forename: Gad
authors.initials: G
authors.lastname: Getz
authors.forename: Holger
authors.initials: H
authors.lastname: Höfling
authors.forename: Jill P
authors.initials: JP
authors.lastname: Mesirov
authors.forename: Todd R
authors.initials: TR
authors.lastname: Golub
authors.forename: Matthew
authors.initials: M
authors.lastname: Meyerson
authors.forename: Robert
authors.initials: R
authors.lastname: Tibshirani
authors.forename: Eric S
authors.initials: ES
authors.lastname: Lander
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D016384:Consensus Sequence; D005260:Female; D052138:Genes, Neoplasm; D015894:Genome, Human; D006801:Humans; D008297:Male; D009154:Mutation; D011336:Probability