A new isocoumarin from Hypericum annulatum.
A new isocoumarin, annulatomarin (1), together with the known physcion and beta-sitosterol were isolated from the aerial parts of Hypericum annulatum. The structure of the new compound was established as 6,8-dihydroxy-7-methoxy-3-phenyl-3,4-dihydro-1H-isochromen-1-one on the basis of detailed spectroscopic analysis. Annulatomarin exhibited a modest growth-inhibitory activity in vitro against human chronic myeloid leukaemia LAMA-84 cells with an IC(50) = 111 microM.
Nedialkov
Paraskev T
PT
Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria. pnedialkov@pharmfac.net
Zheleva-Dimitrova
Dimitrina
D
Girreser
Ulrich
U
Kitanov
Gerassim M
GM
D045744:Cell Line, Tumor; D004642:Emodin / Q000031:analogs & derivatives / Q000737:chemistry; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D049934:Isocoumarins / Q000737:chemistry*; D008967:Molecular Biology; D012855:Sitosterols / Q000737:chemistry
D049934:Isocoumarins; D012855:Sitosterols; C525227:annulatomarin; C025473:gamma-sitosterol; C008905:physcione; D004642:Emodin