Gastric stasis occurs in spontaneous, visually induced, and interictal migraine.
OBJECTIVE
To evaluate and compare gastric motility and emptying during spontaneous migraine to previous observations from induced migraine.


BACKGROUND
We have previously demonstrated a delay in gastric emptying both during the interictal period and during an induced migraine. A limitation noted in these studies was whether there are differences gastrointestinally during a visually induced migraine compared to spontaneous migraines. To address this, 9 additional studies have been performed to ascertain if there is a similar delay during spontaneous migraine


METHODS
Gastric scintigraphy using a standard meal was performed in 3 subjects during 3 periods: spontaneous migraine, induced migraine, and interictal period.


RESULTS
On average, the time to half emptying was delayed during spontaneous migraine (124 minutes), during induced migraine (182 minutes), and during the interictal period migraine (243 minutes) compared to normative values established at our center (112 minutes). On average, similar gastric slowing was seen in all 3 groups when the percentage of nuclear material remaining in the stomach at 2 hours was measured.


CONCLUSIONS
This study provides additional evidence of gastric stasis in migraineurs interictally during induced and spontaneous migraine.
Aurora
Sheena
S
Swedish Neuroscience Institute - Swedish Headache Center, Seattle, WA 98104, USA.
Kori
Shashidhar
S
Barrodale
Patricia
P
Nelsen
Andrew
A
McDonald
Susan
S
D000328:Adult; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D018589:Gastroparesis / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000209:etiology; D010775:Photic Stimulation / Q000009:adverse effects; D011877:Radionuclide Imaging / Q000379:methods; D013997:Time Factors