title: Epidemiology and clinical outcome of candidaemia among Jordanian newborns over a 10-year period.
abstract: This retrospective study includes all newborn patients with culture proved candidaemia who were admitted to the neonatal intensive care unit of Jordan University Hospital through the period January 1995 to June 2006. Among 24 patients included, 13 (54.2%) died. The incidence of candidaemia was 0.27%, the mean age at diagnosis 25.9 d and the mean gestational age at birth 34.6 weeks. Species most frequently isolated were Candida albicans (50%) and C. krusei (20%). Previous gastrointestinal pathology was present in 41.7% of the cases. A comparison of cases due to C. albicans with those due to other species of Candida revealed no statistical differences in terms of demographic factors, age at onset of disease, mortality, clinical manifestations or risk factors. Based on our results, empirical antifungal therapy should be considered in neonates who have gastrointestinal pathology and other risk factors.
authors.affiliation: Department of Neonatology, Jordan University Hospital, Amman, Jordan. emantaj@hotmail.com
authors.forename: Eman F
authors.initials: EF
authors.lastname: Badran
authors.forename: Jumana H
authors.initials: JH
authors.lastname: Al Baramki
authors.forename: Abdulqader
authors.initials: A
authors.lastname: Al Shamyleh
authors.forename: Asem
authors.initials: A
authors.lastname: Shehabi
authors.forename: Najwa
authors.initials: N
authors.lastname: Khuri-Bulos
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects; D005260:Female; D016469:Fungemia / Q000188:drug therapy / Q000453:epidemiology*; D017052:Hospital Mortality; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D007597:Jordan / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents