title: Protective effect of viscoelastics against retina lipid peroxidation.
abstract: Viscoelastics or ophthalmic viscosurgical devices are routinely used during anterior segment surgery and also in posterior segment surgery. Studies of the harmful effects of phacoemulsification on corneal endothelial cells suggest that much of this damage is mediated by free radicals. In this study, we compare the possible effects against lipid peroxidation in the retina of three different viscoelastic substances: Viscoat, Healon and Visiol. Herein we demonstrate for the first time that viscoelastics are effective to protect the retina against lipid peroxidation, as can be seen by the slight increase of malondialdehyde in the homogenates incubated with viscoelastic exposed to light and to a temperature of 37 degrees C when compared with the control homogenates.
authors.affiliation: Universidad Cardenal Herrera - CEU, Valencia, España.
authors.forename: M
authors.initials: M
authors.lastname: Miranda
authors.forename: F
authors.initials: F
authors.lastname: Bosch-Morell
authors.forename: J I
authors.initials: JI
authors.lastname: Belda
authors.forename: M D
authors.initials: MD
authors.lastname: García-Manzanares
authors.forename: J
authors.initials: J
authors.lastname: Barcia
authors.forename: J L
authors.initials: JL
authors.lastname: Alió
authors.forename: F J
authors.initials: FJ
authors.lastname: Romero
mesh_terms: D000818:Animals; D002417:Cattle; D002807:Chondroitin / Q000494:pharmacology*; D002809:Chondroitin Sulfates; D004338:Drug Combinations; D005260:Female; D006820:Hyaluronic Acid / Q000494:pharmacology*; D066298:In Vitro Techniques; D007552:Isotonic Solutions / Q000494:pharmacology*; D008027:Light; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects; D008315:Malondialdehyde / Q000378:metabolism; D009994:Osmolar Concentration; D012160:Retina / Q000378:metabolism*; D013696:Temperature; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D007552:Isotonic Solutions; C501944:chondroitin sulfate, sodium hyaluronate drug combination; D008315:Malondialdehyde; D006820:Hyaluronic Acid; D002807:Chondroitin; D002809:Chondroitin Sulfates