Clinical evaluation of silicone hydrogel lens wear with a new multipurpose disinfection care product.
OBJECTIVE
To evaluate subjective symptoms and clinical signs in silicone hydrogel contact lens wearers with three different multipurpose solution (MPS) lens care regimens.


METHODS
In a double-masked, randomized, concurrently controlled study, 233 subjects from 12 clinical sites wore one of two silicone hydrogel lens brands (ACUVUE Advance or Focus NIGHT & DAY) for 1 month on a daily-wear basis supported by a new reconditioning multipurpose disinfecting solution (MPDS) preserved with POLYQUAD and ALDOX, regimen 1 (OPTI-FREE RepleniSH Multi-Purpose Disinfecting Solution), or by one of two MPSs preserved with polyhexamethyl biguanide, regimen 2 (ReNu MultiPlus Multi-Purpose Solution No Rub Formula) or regimen 3 (Complete MoisturePLUS Multi-Purpose Solution).


RESULTS
Significant differences in favor of regimen 1 were found in subjective responses of subjects wearing ACUVUE Advance lenses. For Focus NIGHT & DAY lens wearers, regimen 1 was associated with significantly less corneal staining (severity [P=0.0019], area [P=0.0077]) than regimen 2 was. The average number of times per day that rewetting drops were used was significantly higher for subjects randomized to regimen 3 than for subjects using regimen 1.


CONCLUSIONS
The clinical performance of the new MPDS product with silicone hydrogel lenses was generally as good as or better than the two comparative polyhexamethyl biguanide-preserved MPSs. Clinical differences were evident between the products. Practitioners should be aware that MPS product choice for use with silicone hydrogel lenses may lead to different clinical outcomes, particularly in regard to stress on the ocular surface, as evidenced by the corneal staining response.
Zigler
Lamar
L
Central Ohio Eye Care, Inc., Columbus, OH 43202, USA. lgzod@aol.com
Cedrone
Ronald
R
Evans
David
D
Helbert-Green
Carolyn
C
Shah
Tapan
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018639:Contact Lens Solutions / Q000009:adverse effects; D003262:Contact Lenses, Extended-Wear; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D004311:Double-Blind Method; D015352:Dry Eye Syndromes / Q000517:prevention & control; D005260:Female; D019793:Fluorescein; D005456:Fluorescent Dyes; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D011310:Preservatives, Pharmaceutical; D012828:Silicones; D013194:Staining and Labeling
D018639:Contact Lens Solutions; D005456:Fluorescent Dyes; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical; D012828:Silicones; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D019793:Fluorescein