title: Inflammatory markers are elevated in overweight Mexican-American children.
abstract: OBJECTIVE
  The purpose of the present study was to determine the effect of body weight on blood lipid profile, insulin resistance and inflammatory biomarkers in Mexican-American children.
  
  
  METHODS
  Children (13.3+/-0.1 year) were recruited from a local school and assigned to one of three groups as a volunteer sample: healthy weight (HW) (> or =10th and <85th BMI percentile; n=42), at risk of overweight (RO) (> or =85th and <95th; n =25) or overweight (OW) (> or =95th; n=42). Plasma concentrations of hsCRP, sCD14, sIL-6R, sTNF-alphaR1, sTNF-alphaR2, IL-6 and TNF-alpha were determined by ELISA.
  
  
  RESULTS
  OW children had significantly greater plasma concentrations of hsCRP (P =0.003), sCD14 (P =0.013), sIL-6R (P =0.010), sTNF-alphaR1 (P<0.001), sTNF-alphaR2 (P=0.005), insulin (P=0.001), TC:HDL ratio (P<0.001) and triglycerides (P <0.001) than HW children. Also plasma concentrations of hsCRP, sIL-6R and sTNF-alphaR1 were significantly greater in OW compared with RO children.
  
  
  CONCLUSIONS
  Overweight Mexican-American children had a higher concentration of inflammatory biomarkers than healthy weight children. To our knowledge, this is the first study to report that sCD14 is elevated in overweight compared with healthy weight Mexican-American children.
authors.affiliation: Department of Health and Human Performance, Laboratory of Integrated Physiology University of Houston, Houston, Texas, 77204-6015, USA. bmcfarlin@uh.edu
authors.forename: Brian K
authors.initials: BK
authors.lastname: McFarlin
authors.forename: Craig A
authors.initials: CA
authors.lastname: Johnston
authors.forename: Chermaine
authors.initials: C
authors.lastname: Tyler
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Hutchison
authors.forename: Michael L
authors.initials: ML
authors.lastname: Kueht
authors.forename: Rebecca
authors.initials: R
authors.lastname: Reeves
authors.forename: John P
authors.initials: JP
authors.lastname: Foreyt
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D018950:Lipopolysaccharide Receptors / Q000097:blood; D008297:Male; D017058:Mexican Americans / Q000706:statistics & numerical data*; D050177:Overweight / Q000097:blood* / Q000208:ethnology / Q000503:physiopathology; D019947:Receptors, Interleukin-6 / Q000097:blood; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014481:United States / Q000453:epidemiology; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D018836:Inflammation Mediators; D007328:Insulin; D008055:Lipids; D018950:Lipopolysaccharide Receptors; D019947:Receptors, Interleukin-6; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein