Renierosides, cerebrosides from a marine sponge Haliclona (Reniera) sp.
Guided by the brine shrimp lethality assay, eight new cerebrosides (1-8) have been isolated from an extract of the marine sponge Haliclona (Reniera) sp. A novel feature of these cerebrosides was the presence of unprecedented amide-linked long-chain fatty acid moieties. The planar structures of the cerebrosides (1-8) were established by 1D and 2D NMR spectroscopic techniques, mass spectrometric analyses, and chemical degradation methods. The isolated compounds did not display cytotoxicity to a panel of five human solid tumor cell lines.
Mansoor
Tayyab A
TA
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Shinde
Pramod B
PB
Luo
Xuan
X
Hong
Jongki
J
Lee
Chong-O
CO
Sim
Chung Ja
CJ
Son
Byeng Wha
BW
Jung
Jee H
JH
D000818:Animals; D001156:Artemia / Q000187:drug effects; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047129:Haliclona / Q000737:chemistry*; D006801:Humans; D007723:Korea; D015394:Molecular Structure
D002554:Cerebrosides; D006027:Glycosides