title: Increased glycation of hemoglobin and plasma proteins in normotensive, non-diabetic obese Indian subjects: putative role of lipid peroxides.
abstract: BACKGROUND
  Glycation and lipid peroxidation are spontaneous reactions believed to contribute to the pathogenesis of many clinical disorders. The purpose of the present study was to evaluate the levels of lipid peroxides and glycated proteins in normotensive, non-diabetic obese Indian subjects and to assess possible associations between them.
  
  
  METHODS
  A total of 28 obese male subjects and 20 non-obese subjects were included in the present study. Whole blood glycated hemoglobin, plasma lipid peroxides and fructosamine levels were estimated in both groups.
  
  
  RESULTS
  Lipid peroxides, glycated hemoglobin and fructosamine levels were significantly higher in obese subjects in comparison with non-obese subjects. We also found a significant association between malondialdehyde and body mass index (r=0.424, p=0.025). Partial correlation analysis revealed that malondialdehyde was significantly correlated with glycated hemoglobin (r=0.590, p=0.01) and fructosamine (r=0.442, p=0.021) after controlling for glucose.
  
  
  CONCLUSIONS
  Increased glycation of proteins was found in normotensive, non-diabetic obese Indian subjects. These data also support the premise that lipid peroxides per se play a role in the glycation of hemoglobin and plasma proteins.
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Sathiyapriya
authors.forename: Nambiar
authors.initials: N
authors.lastname: Selvaraj
authors.forename: Hanumanthappa
authors.initials: H
authors.lastname: Nandeesha
authors.forename: Zachariah
authors.initials: Z
authors.lastname: Bobby
authors.forename: Aparna
authors.initials: A
authors.lastname: Agrawal
authors.forename: Magadi Gopalakrishna
authors.initials: MG
authors.lastname: Sridhar
authors.forename: Purushothaman
authors.initials: P
authors.lastname: Pavithran
authors.forename: Nadaradjan
authors.initials: N
authors.lastname: Rattina Dasse
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000032:analysis / Q000378:metabolism*; D015992:Body Mass Index; D016022:Case-Control Studies; D019270:Fructosamine / Q000097:blood; D006031:Glycosylation; D006454:Hemoglobins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007194:India; D008054:Lipid Peroxides / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D008054:Lipid Peroxides; D019270:Fructosamine; D008315:Malondialdehyde