The genus Gluconobacter oxydans: comprehensive overview of biochemistry and biotechnological applications.
The genus Gluconobacter comprises some of the most frequently used microorganisms when it comes to biotechnological applications. Not only has it been involved in "historical" production processes, such as vinegar production, but in the last decades many bioconversion routes for special and rare sugars involving Gluconobacter have been developed. Among the most recent are the biotransformations involved in the production of L-ribose and miglitol, both very promising pharmaceutical lead molecules. Most of these processes make use of Gluconobacter's membrane-bound polyol dehydrogenases. However, recently other enzymes have also caught the eye of industrial biotechnology. Among them are dextran dextrinase, capable of transglucosylating substrate molecules, and intracellular NAD-dependent polyol dehydrogenases, of interest for co-enzyme regeneration. As such, Gluconobacter is an important industrial microbial strain, but it also finds use in other fields of biotechnology, such as biosensor-technology. This review aims to give an overview of the myriad of applications for Gluconobacter, with a special focus on some recent developments.
De Muynck
Cassandra
C
Laboratory of Industrial Microbiology and Biocatalysis, Department of Biochemical and Microbial Technology, Faculty of Bioscience Engineering, Ghent University, Gent, Belgium. cdmuynck@hotmail.com
Pereira
Catarina S S
CS
Naessens
Myriam
M
Parmentier
Sofie
S
Soetaert
Wim
W
Vandamme
Erick J
EJ
D015374:Biosensing Techniques; D001709:Biotechnology; D002384:Catalysis; D020600:Gluconobacter oxydans / Q000166:cytology / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction; D011108:Polymers / Q000378:metabolism
D011108:Polymers