title: Hyperlipidemia is associated with accelerated chronic kidney disease progression after lung transplantation.
abstract: Hyperlipidemia is associated with faster progression of chronic kidney disease (CKD) in the general public. We sought to investigate this association after lung transplantation. Data was retrospectively collected on 230 lung recipients transplanted between January 1997 and December 2003. Estimated glomerular filtration rates (eGFR) and lipid levels were recorded at regular intervals posttransplant. Independent associations between lipid levels early posttransplant and pertinent renal endpoints were investigated. Baseline LDL was 110 +/- 35 mg/dL and remained unchanged at 6 months. A faster decline in eGFR was seen in those with 6 month LDLs > versus < the mean level of 110 mg/dL (p = 0.05). By 6 months posttransplant eGFRs were lower in the 6 month LDL > versus < 110 mg/dL group (53 +/- 23 vs. 62 +/- 29 mL/min/1.73 m2, p = 0.01), a difference that persisted at 60 months (39 +/- 24 vs. 73 +/- 57 mL/min/1.73 m2, p = 0.05). On univariate analysis, a 6 month LDL in the highest quartile, i.e. >140 mg/dL, predicted faster progression to CKD, defined as declining to an eGFR < 30 mL/min/1.73 m2 (HR 1.5, p = 0.01). This finding persisted in the multivariate Cox-proportional model (HR 1.4, p = 0.02). Hyperlipidemia predicts faster decline in renal function after lung transplant. Prospective trials are needed to confirm this finding.
authors.affiliation: Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, USA. stephab@ccf.org
authors.forename: B R
authors.initials: BR
authors.lastname: Stephany
authors.forename: B
authors.initials: B
authors.lastname: Alao
authors.forename: M
authors.initials: M
authors.lastname: Budev
authors.forename: M
authors.initials: M
authors.lastname: Boumitri
authors.forename: E D
authors.initials: ED
authors.lastname: Poggio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018450:Disease Progression; D006085:Graft Survival; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology*; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000503:physiopathology; D008171:Lung Diseases / Q000145:classification / Q000401:mortality; D016040:Lung Transplantation / Q000401:mortality / Q000473:pathology* / Q000502:physiology*; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D016019:Survival Analysis