Effector functions of pathogenic Yersinia species.
Pathogenic species of the genus Yersinia suppress and reorient the immune system to infect lymphatic tissues, inner organs and at times also the vasculature. For this purpose yersiniae employ a type III secretion system to translocate effector proteins (Yersinia outer proteins; Yops) into immune cells. Yops often exert unique biochemical activities for modulating the activity of Rho GTP-binding proteins, focal adhesion proteins, inflammatory pathways and cell survival/apoptosis. In this review we will put emphasis on the biochemistry, cell- and infection biology of Yersinia effector Yops.
Aepfelbacher
Martin
M
Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Diagnostikzentrum, Universitätsklinikum Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. m.aepfelbacher@uke.uni-hamburg.de
Trasak
Claudia
C
Ruckdeschel
Klaus
K
D000818:Animals; D000942:Antigens, Bacterial / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism; D018988:Bacterial Translocation; D003546:Cysteine Endopeptidases / Q000378:metabolism; D022001:Focal Adhesions / Q000378:metabolism; D006801:Humans; D050296:Microbial Viability; D052899:Pore Forming Cytotoxic Proteins / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D018805:Sepsis / Q000201:enzymology / Q000378:metabolism* / Q000382:microbiology; D015398:Signal Transduction; D013729:Terpenes / Q000378:metabolism; D014774:Virulence; D015007:Yersinia / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity*; D015009:Yersinia Infections / Q000201:enzymology / Q000378:metabolism* / Q000382:microbiology; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C043908:LcrV protein, Yersinia; D052899:Pore Forming Cytotoxic Proteins; D013729:Terpenes; C109227:YopP protein, Yersinia; C116117:YopT protein, Yersinia; C063239:yopE protein, Yersinia; C060772:yopM protein, Yersinia; C415206:YopO protein, Yersinia enterocolitica; D017346:Protein Serine-Threonine Kinases; D017027:Protein Tyrosine Phosphatases; C067571:yopH protein, Yersinia; D003546:Cysteine Endopeptidases; D020741:rho GTP-Binding Proteins