New insights into the enantioselectivity in the hydrogenation of prochiral ketones.
The high enantioselectivity in the hydrogenation of acetophenone catalysed by trans-Ru(H)2(S,S-dpen)(S-xylbinap) is explained in terms of the existence of a stable intermediate formed when the reactant enters the catalyst pocket fixing the molecular orientation.
French
Samuel A
SA
Johnson Matthey Technology Centre, Blount's Court, Sonning Common, UK RG4 9NH. frencsa@matthey.com
Di Tommaso
Devis
D
Zanotti-Gerosa
Antonio
A
Hancock
Fred
F
Catlow
C Richard A
CR
D006859:Hydrogen / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D013237:Stereoisomerism
D007659:Ketones; D006859:Hydrogen