title: Synthesis, spectroscopic and biological aspects of iron(II) complexes.
abstract: Five novel coordinated complexes of iron(II) with ciprofloxacin and neutral bidentate ligands have been prepared and characterized using elemental analyses, magnetic measurements, IR spectra, UV-VIS spectral, thermogravimetric analyses, 1H-NMR and 13C-NMR. The antimicrobial activity of the individual ligands, metal salt and metal complexes with respect to Bacillus subtilis, Escherichia coli, Bacillus cereus, Staphylococcus aureus, Salmonella typhi, Serratia marcescens, Aspergillus niger, Aspergillus flavus and Lasiodiplodia theobromae were evaluated by the agar-plate technique in comparison to reference standard drugs (ofloxacin, levofloxacin and fluconozole). Binding of the complexes to DNA was studied and is discussed.
authors.affiliation: Department of Chemistry-Sardar Patel University, Vallabh Vidyanagar, 388 120 Gujarat, India.
authors.forename: Pramod B
authors.initials: PB
authors.lastname: Pansuriya
authors.forename: Pinakin
authors.initials: P
authors.lastname: Dhandhukia
authors.forename: Vasudev
authors.initials: V
authors.lastname: Thakkar
authors.forename: Mohan N
authors.initials: MN
authors.lastname: Patel
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D001230:Aspergillus / Q000378:metabolism; D001409:Bacillus cereus / Q000378:metabolism; D001412:Bacillus subtilis / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D007501:Iron / Q000737:chemistry*; D058085:Iron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D012485:Salmonella typhi / Q000378:metabolism; D012706:Serratia marcescens / Q000378:metabolism; D013055:Spectrophotometry, Infrared / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D013211:Staphylococcus aureus / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D058085:Iron Compounds; D007501:Iron