title: Lamotrigine intoxication provoking status epilepticus in an adult with localization-related epilepsy.
abstract: BACKGROUND
  Various anticonvulsant medications have been associated with paradoxical aggravation of epileptic seizures in therapeutic doses and toxic concentrations. Lamotrigine has been reported to exacerbate seizures and myoclonic seizures in generalized epilepsy in a child with localization-related epilepsy.
  
  
  OBJECTIVE
  To describe lamotrigine intoxication paradoxically producing status epilepticus in an adult with localization-related epilepsy.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  Neurology service, inpatient hospitalization, and outpatient follow-up in a neurology clinic.
  
  
  METHODS
  A patient with known localization-related epilepsy who ingested an overdose of lamotrigine tablets in a suicide attempt.
  
  
  METHODS
  None.
  
  
  METHODS
  Observation of the course of the patient's reaction to lamotrigine intoxication, monitoring of lamotrigine levels, and monitoring of ictal and postictal status.
  
  
  RESULTS
  The patient developed a prolonged convulsive status epilepticus, which was eventually controlled with benzodiazepines. The patient also developed transient obtundation and severe ataxia, all of which resolved completely within 96 hours.
  
  
  CONCLUSIONS
  To our knowledge, in addition to being the first case report to describe convulsive status epilepticus after lamotrigine intoxication, this is the first report of the proconvulsant effect of lamotrigine in a case of localization-related epilepsy in an adult. The effects of accidental or suicidal ingestion of lamotrigine tablets seem to be reversible.
authors.affiliation: Section of Neurology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756, USA. ericdinnerstein@maineneurology.com
authors.forename: Eric
authors.initials: E
authors.lastname: Dinnerstein
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Jobst
authors.forename: Peter D
authors.initials: PD
authors.lastname: Williamson
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000506:poisoning*; D004569:Electroencephalography; D004829:Epilepsy, Generalized / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D019635:Neurosurgical Procedures; D013226:Status Epilepticus / Q000139:chemically induced*; D013406:Suicide, Attempted; D014227:Triazines / Q000506:poisoning*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine