A Belgian registry of interleukin-2 administration for treatment of metastatic renal cell cancer and confrontation with literature data.
In an effort to map the use of interleukin-2 (IL-2) treatment in patients with clear cell renal cell cancer (RCC) in Belgian hospitals, 44 cases were registered from 9 hospitals between February 2003 and June 2006. It was demonstrated that the majority of these patients were treated with subcutaneous (SC) IL-2. Other methods such as the inhalation of the drug in case of intrathoracic disease or high dose intravenous (IV) administration were much less frequent (3 and 0 cases in this registry, respectively). The results of antitumour activity (around 16% partial response-absence of complete responses) and toxicity of this drug correlate with observations from the literature with the SC administration. In view of the poor results and tolerance with the currently used cytokines (IL-2 or interferon-alfa), much hope is directed towards the development of the novel targeted drugs like sunitinib or sorafenib used alone or in combination with cytokines in this disease.
Bambust
I
I
Universitair Ziekenhuis Gent, Department of Medical Oncology.
Van Aelst
F
F
Joosens
E
E
Schallier
D
D
Rezaei Kalantari
H
H
Paulus
R s
Rs
Renard
V
V
Clausse
M
M
Duck
L
L
Luce
S
S
Pierre
P
P
Van Belle
S
S
Rottey
S
S
D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001530:Belgium; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000556:secondary*; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data; D012042:Registries; D012189:Retrospective Studies; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D007376:Interleukin-2