title: Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus.
abstract: To investigate the influence of sex hormones on the development of systemic lupus erythematosus (SLE), we examined the estrogen receptor (ER) expression by peripheral blood mononuclear cells (PBMC) in patients with SLE using the real-time quantitative polymerase chain reaction (TaqMan) method. The expression of messenger RNA (mRNA) for ER alpha (ERa) was increased and expression of ER beta (ERb) mRNA was decreased in PBMC from SLE patients compared with PBMC from normal controls. These findings may be useful for elucidation of the pathophysiology of SLE.
authors.affiliation: Department of General Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Inui
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ogasawara
authors.forename: Toshio
authors.initials: T
authors.lastname: Naito
authors.forename: Iwao
authors.initials: I
authors.lastname: Sekigawa
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Takasaki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hayashida
authors.forename: Kenji
authors.initials: K
authors.lastname: Takamori
authors.forename: Hideoki
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D047628:Estrogen Receptor alpha / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D011960:Receptors, Estrogen / Q000097:blood*; D012737:Sex Factors
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D012333:RNA, Messenger; D011960:Receptors, Estrogen