title: Auto-reactive B cells in transgenic mice.
abstract: In order to understand how the natural occurrence of autoreactive B cells is controlled in normal individuals, and how self reactive B cells can escape this control during diverse clinical situations, many different transgenic mice have been generated expressing self reactive antibodies. In this review, we focus our attention on disease-associated self reactive transgenic models which show the variety of the tolerization mechanisms. The same transgenic lines are also used to analyse the effects of the autoimmune genetic background on the self reactive B cell fate, as well as to study the influence of infectious agents on the behaviour of the auto-reactive transgenic B cells.
authors.affiliation: Laboratory of Immunopathology, INSERM U 737 and Université Louis Pasteur, Hopitaux Universitaires de Strasbourg, 67 091 Strasbourg, France. jean-louis.pasquali@chru-strasbourg.fr
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Pasquali
authors.forename: Pauline
authors.initials: P
authors.lastname: Soulas-Sprauel
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Korganow
authors.forename: Thierry
authors.initials: T
authors.lastname: Martin
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D008822:Mice, Transgenic / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens