Do ligand binding and solvent exclusion alter the electrostatic character within the oxyanion hole of an enzymatic active site?
Sigala
Paul A
PA
Departments of Chemistry and Biochemistry, Stanford University, Stanford, California 94305-5307, USA.
Fafarman
Aaron T
AT
Bogard
Patrick E
PE
Boxer
Steven G
SG
Herschlag
Daniel
D
D000838:Anions; D001665:Binding Sites; D007700:Kinetics; D008024:Ligands; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism; D016958:Pseudomonas putida / Q000201:enzymology; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D013251:Steroid Isomerases / Q000737:chemistry* / Q000378:metabolism; D013861:Thiocyanates / Q000737:chemistry
D000838:Anions; D008024:Ligands; D012997:Solvents; D013861:Thiocyanates; D013251:Steroid Isomerases; D010100:Oxygen