title: Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever.
abstract: Coxiella burnetii is a macrophage-tropic, Gram-negative organism, which causes acute Q fever infection in humans. This zoonotic infection causes illness ranging from asymptomatic seroconversion to severe and protracted disease featuring hepatitis and pneumonia. Interactions between C. burnetii lipopolysaccharide (LPS) and host Toll-like receptors (TLR)-2 and -4 have been implicated in pathogen recognition, phagocytosis and signaling responses. Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (Arg677Trp and Arg753Gln) and TLR-4 (Asp299Gly) have been found to correlate with mycobacterial infections and Gram-negative sepsis respectively. Associations between the TLR-2 and -4 polymorphisms, illness characteristics and immune response parameters were examined in subjects with acute Q fever (n=85) and comparison subjects with viral infections (n=162). No correlation was demonstrated between these polymorphisms and susceptibility to Q fever, illness severity or illness course.
authors.affiliation: Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: B
authors.initials: B
authors.lastname: Everett
authors.forename: B
authors.initials: B
authors.lastname: Cameron
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: U
authors.initials: U
authors.lastname: Vollmer-Conna
authors.forename: T
authors.initials: T
authors.lastname: Davenport
authors.forename: I
authors.initials: I
authors.lastname: Hickie
authors.forename: D
authors.initials: D
authors.lastname: Wakefield
authors.forename: S
authors.initials: S
authors.lastname: Vernon
authors.forename: W C
authors.initials: WC
authors.lastname: Reeves
authors.forename: A R
authors.initials: AR
authors.lastname: Lloyd
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007109:Immunity / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011778:Q Fever / Q000235:genetics* / Q000276:immunology; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*
chemical_list: C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4