title: Synthesis of chalcone derivatives on steroidal framework and their anticancer activities.
abstract: Chalcone derivatives on estradiol framework have been synthesized. Some of the derivatives showed potent anticancer activity against some human cancer cell lines. Compounds 9 and 19 showed potent activity against MCF-7, a hormone dependent breast cancer cell line. Chalcone 7 was further modified to the corresponding indanone derivative (19) using the Nazarov reaction, which showed better activity than the parent compound against the MCF-7 breast cancer cell line. Active anticancer derivatives were also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that chalcone derivatives showing cytotoxicity against cancer cell lines did not affect the fragility of erythrocytes and hence may be considered as non-toxic to normal cells.
authors.affiliation: Central Institute of Medicinal and Aromatic Plants (CIMAP), P.O. CIMAP, Kukrail Picnic Spot Road, Lucknow, U.P., India.
authors.forename: Hari Om
authors.initials: HO
authors.lastname: Saxena
authors.forename: Uzma
authors.initials: U
authors.lastname: Faridi
authors.forename: J K
authors.initials: JK
authors.lastname: Kumar
authors.forename: Suaib
authors.initials: S
authors.lastname: Luqman
authors.forename: M P
authors.initials: MP
authors.lastname: Darokar
authors.forename: Karuna
authors.initials: K
authors.lastname: Shanker
authors.forename: Chandan S
authors.initials: CS
authors.lastname: Chanotiya
authors.forename: M M
authors.initials: MM
authors.lastname: Gupta
authors.forename: Arvind S
authors.initials: AS
authors.lastname: Negi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002599:Chalcone / Q000031:analogs & derivatives*; D004958:Estradiol / Q000737:chemistry*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D004958:Estradiol; D002599:Chalcone