Hepatocellular carcinoma in a noncirrhotic patient with hereditary hemochromatosis.
We report the case of a 66-year-old man with genetic hemochromatosis who was found to have hepatocellular carcinoma (HCC) in the absence of cirrhosis. This is a rare and life-threatening complication of noncirrhotic hemochromatosis that has been described only 10 times in the English literature. In addition to presenting our case, we also cite some other potential causes of HCC in noncirrhotic patients that should be clinically considered. Although the incidence of HCC in noncirrhotic hemochromatosis patients is not sufficiently high to warrant routine screening, physicians should be aware that this fatal complication may rarely occur.
Hiatt
Tadd
T
Division of Gastroenterology/Hepatology, University of Colorado Health Sciences Center, Denver, Colorado 80045, USA.
Trotter
James F
JF
Kam
Igal
I
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology*; D006432:Hemochromatosis / Q000150:complications* / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016896:Treatment Outcome