title: Pain in oxaliplatin-induced neuropathy--sensitisation in the peripheral and central nociceptive system.
abstract: BACKGROUND
  This study aimed to determine the somatosensory characteristics and pain types in patients with acute oxaliplatin-induced neuropathy and to relate this profile to the hereby detected underlying pathophysiological mechanisms.
  
  
  METHODS
  Sixteen patients treated with oxaliplatin for cancer were characterised with neurological assessment and a standardised and validated set for quantitative sensory testing (QST). Patients were allocated to two groups depending on the presence or absence of pain symptoms of acute neuropathy.
  
  
  RESULTS
  Comparison with normative data revealed in patients with pain symptoms a characteristic somatosensory profile of cold and mechanical hyperalgesia. Group-to-group analysis revealed additional heat hyperalgesia and warm hypoesthesia.
  
  
  CONCLUSIONS
  Pain symptoms of acute oxaliplatin-induced neuropathy are related to signs of sensitisation within the peripheral (cold and heat hyperalgesia) and central nervous nociceptive system (mechanical hyperalgesia). This strengthens the rationale for treatment with anticonvulsants and antidepressants and fosters research on ion channel and receptor related mechanisms.
authors.affiliation: Division of Neurological Pain Research and Therapy, Christian-Albrechts-Universität Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany. a.binder@neurologie.uni-kiel.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Binder
authors.forename: Maike
authors.initials: M
authors.lastname: Stengel
authors.forename: Rainer
authors.initials: R
authors.lastname: Maag
authors.forename: Gunnar
authors.initials: G
authors.lastname: Wasner
authors.forename: Robert
authors.initials: R
authors.lastname: Schoch
authors.forename: Frank
authors.initials: F
authors.lastname: Moosig
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schommer
authors.forename: Ralf
authors.initials: R
authors.lastname: Baron
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy*; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000139:chemically induced*; D009619:Nociceptors / Q000187:drug effects; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D017288:Pain Threshold / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin