title: Complement C4B protein in schizophrenia.
abstract: Partial and/or complete deficiency of the complement protein C4 is associated with autoimmune and infectious diseases. Infectious or autoimmune processes may have a role in schizophrenia. Previous reports suggest abnormalities in the complement C4B isotype in schizophrenia and other mental disorders. We assessed C4A and C4B isotypes and serum C4B protein concentration in Armenian schizophrenic patients. Although there was no difference in frequency of C4BQ0, C4B serum protein level was significantly decreased in the schizophrenic patients compared with healthy controls.
authors.affiliation: MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, UK. karine.mayilyan@bioch.ox.ac.uk
authors.forename: Karine R
authors.initials: KR
authors.lastname: Mayilyan
authors.forename: Alister W
authors.initials: AW
authors.lastname: Dodds
authors.forename: Anna S
authors.initials: AS
authors.lastname: Boyajyan
authors.forename: Armen F
authors.initials: AF
authors.lastname: Soghoyan
authors.forename: Robert B
authors.initials: RB
authors.lastname: Sim
mesh_terms: D015935:Complement C4b / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000378:metabolism* / Q000503:physiopathology*
chemical_list: D015935:Complement C4b