title: Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures.
abstract: A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and squamous cell carcinoma. Additionally, undifferentiated spindle or pleomorphic cells were seen in continuity with the carcinoma component. Undifferentiated neoplastic cells with rhabdoid features and with hyaline globule-like structures positive for PAS stain with diastase pretreatment were also observed. Immunohistochemically, cytoplasmic inclusions corresponding to rhabdoid features showed aggregates of vimentin. Ultrastructurally, hyaline globule-like structures corresponded to lysosomes. Finally, we report here the first case of anaplastic carcinoma of the pancreas with hyaline globule-like structures.
authors.affiliation: Department of Pathology, Kochi Red Cross Hospital, 2-13-51 Shin-honmachi, Kochi City, Kochi 780-8562, Japan. nkurodakrch@yahoo.co.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Kuroda
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Iwamura
authors.forename: Nokiaki
authors.initials: N
authors.lastname: Fujishima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ohara
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirouchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Mizuno
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Gang-Hong
authors.initials: GH
authors.lastname: Lee
mesh_terms: D002277:Carcinoma / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D006818:Hyalin / Q000378:metabolism* / Q000648:ultrastructure; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D018335:Rhabdoid Tumor / Q000473:pathology* / Q000648:ultrastructure