title: Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
abstract: HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.
authors.affiliation: Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. tzheng@bsd.uchicago.edu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Tan
authors.forename: Glenn
authors.initials: G
authors.lastname: Randall
authors.forename: Jihua
authors.initials: J
authors.lastname: Fan
authors.forename: Blanca
authors.initials: B
authors.lastname: Camoretti-Mercado
authors.forename: Rebecca
authors.initials: R
authors.lastname: Brockman-Schneider
authors.forename: Lin
authors.initials: L
authors.lastname: Pan
authors.forename: Julian
authors.initials: J
authors.lastname: Solway
authors.forename: James E
authors.initials: JE
authors.lastname: Gern
authors.forename: Robert F
authors.initials: RF
authors.lastname: Lemanske
authors.forename: Dan
authors.initials: D
authors.lastname: Nicolae
authors.forename: Carole
authors.initials: C
authors.lastname: Ober
mesh_terms: D020413:3' Untranslated Regions; D000483:Alleles; D001249:Asthma / Q000235:genetics* / Q000276:immunology*; D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D020413:3' Untranslated Regions; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D035683:MicroRNAs