[Correction of changes induced by toluene in the cortical and subcortical structures of albino rat brain].
The number and weight of cells in the cortical and subcortical structures of the cerebral and cerebellar motor system in albino rats after a long-term exposure to toluene. Toluene intoxication proved to kill projection neurons and interneurons in the sensorimotor cortex, ventrolateral thalamic nucleus, caudate nucleus, pallidum, red nucleus, and inferior olivary complex. The decreased number of cerebellar cells was mediated by atrophic changes as indicated by the decrease in the area and dry weight of Purkinje cells. The addition of plaferon LB to the diet attenuated the cytotoxic effect of toluene.
Svanidze
I K
IK
Museridze
D P
DP
Didimova
E V
EV
Gvinadze
N N
NN
Gegenava
L G
LG
Bregvadze
I A
IA
D000818:Animals; D002421:Caudate Nucleus / Q000378:metabolism* / Q000473:pathology; D002529:Cerebellar Nuclei / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D009479:Neuropeptides / Q000494:pharmacology; D011689:Purkinje Cells / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D012012:Red Nucleus / Q000378:metabolism* / Q000473:pathology; D012997:Solvents / Q000633:toxicity*; D014050:Toluene / Q000633:toxicity*; D020651:Ventral Thalamic Nuclei / Q000378:metabolism* / Q000473:pathology
D009479:Neuropeptides; D012997:Solvents; C091912:plaferon; D014050:Toluene