title: Sanionins: anti-inflammatory and antibacterial agents with weak cytotoxicity from the Antarctic moss Sanionia georgico-uncinata.
abstract: Sanionins A (1) and B (2) were isolated from the moss Sanionia georgico-uncinata, collected on the Antarctic Livingston Island. The compounds 1 and 2 were purified by solvent extraction, silica gel column chromatography, and preparative HPLC, consecutively. The structures of the both compounds were elucidated by 1D and 2D NMR experiments and mass spectrometric investigations. These compounds showed activity against important Gram-positive pathogens, such as mycobacteria, multiresistant staphylococci, and vancomycin resistant enterococci. This activity is combined with antiinflammatoric activity and low cytotoxicity.
authors.affiliation: The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria. venibiva@microbio.bas.bg
authors.forename: Veneta
authors.initials: V
authors.lastname: Ivanova
authors.forename: Mariana
authors.initials: M
authors.lastname: Kolarova
authors.forename: Krasja
authors.initials: K
authors.lastname: Aleksieva
authors.forename: Klaus-Juergen
authors.initials: KJ
authors.lastname: Dornberger
authors.forename: Albert
authors.initials: A
authors.lastname: Haertl
authors.forename: Ute
authors.initials: U
authors.lastname: Moellmann
authors.forename: Hans-Martin
authors.initials: HM
authors.lastname: Dahse
authors.forename: Nesho
authors.initials: N
authors.lastname: Chipev
mesh_terms: D000818:Animals; D000864:Antarctic Regions; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity*; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity*; D001632:Bibenzyls / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity*; D044002:Bryophyta / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D004847:Epithelial Cells / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D007739:L Cells; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy; D013058:Mass Spectrometry; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D001632:Bibenzyls; D012997:Solvents; C524950:sanionin A