Ovarian hilus-cell hyperplasia and high serum testosterone in a patient with postmenopausal virilization.
OBJECTIVE
To describe a woman with postmenopausal virilization and hirsutism caused by hilus-cell hyperplasia.


METHODS
We present a case report including laboratory, radiographic, and pathologic findings in a patient with postmenopausal hirsutism and virilization caused by ovarian hilus-cell hyperplasia as well as a brief review of the literature.


RESULTS
A 60-year-old postmenopausal woman presented with extensive hirsutism, male-pattern hair loss, and clitoromegaly. The patient's plasma testosterone levels were very high, but computed tomography showed the adrenal glands to be normal in size. Pelvic ultrasonography revealed a cystic lesion in the left ovary. After bilateral salpingo-oophorectomy, histologic examination demonstrated a diffuse pattern of hilus-cell hyperplasia in the ovarian hilum.


CONCLUSIONS
In the differential diagnosis of postmenopausal virilization, hilus-cell hyperplasia, although rare, should be considered.
Delibasi
Tuncay
T
The Department of Endocrinology and Metabolic Diseases, Ankara University School of Medicine, Ankara, Turkey.
Erdogan
Murat F
MF
Serinsöz
Ebru
E
Kaygusuz
Gulsah
G
Erdogan
Gurbuz
G
Sertçelik
Ayse
A
D005260:Female; D006628:Hirsutism / Q000097:blood / Q000209:etiology; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D010048:Ovarian Cysts / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D010053:Ovary / Q000473:pathology*; D017698:Postmenopause; D013739:Testosterone / Q000097:blood*; D014770:Virilism / Q000097:blood / Q000209:etiology*
D013739:Testosterone