title: A one-step fusion of 1,3-thiazine and pyrimidine cycles.
abstract: The chlorotrimethylsilane-promoted Biginelli type reactions of aldehydes, thiourea, and cyanoketones led to a diverse set of tetrahydropyrimidine-2(1H)-thiones. Under similar conditions, thioureas, benzaldehyde, and cyanoacetamide reacted to give first representatives of hexahydro-5H-pyrimido[5,4-e][1,3]thiazin-5-ones in high preparative yield.
authors.affiliation: Enamine Ltd., 23 A. Matrosova st., 01103 Kyiv, Ukraine. ryabukhin@mail.enamine.net
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Ryabukhin
authors.forename: Andrey S
authors.initials: AS
authors.lastname: Plaskon
authors.forename: Eugeniy N
authors.initials: EN
authors.lastname: Ostapchuk
authors.forename: Dmitriy M
authors.initials: DM
authors.lastname: Volochnyuk
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Shishkin
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Shivanyuk
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Tolmachev