title: Larvicidal and growth inhibition of the malaria vector Anopheles stephensi by triterpenes from Dysoxylum malabaricum and Dysoxylum beddomei.
abstract: Secondary metabolites from Dysoxylum malabaricum and Dysoxylum beddomei were tested against mature and immature stage of the mosquito vector Anopheles stephensi under laboratory conditions. The triterpenes 3beta,24,25-trihydroxycycloartane and beddomeilactone from D. malabaricum and D. beddomei showed strong larvicidal, pupicidal and adulticidal activity. They also affected the reproductive potential of adults by acting as oviposition deterrents. The highest concentration tested (10 ppm) of both compounds evoked more than 90% mortality and oviposition deterrence.
authors.affiliation: Post Graduate and Research Department of Biotechnology, Vivekanandha College W, Trichengode, Namakkal, Tamil Nadu, India. senthilkalaidr@hotmail.com
authors.forename: S Senthil
authors.initials: SS
authors.lastname: Nathan
authors.forename: A
authors.initials: A
authors.lastname: Hisham
authors.forename: G
authors.initials: G
authors.lastname: Jayakumar
mesh_terms: D000818:Animals; D000852:Anopheles / Q000187:drug effects*; D005260:Female; D006801:Humans; D007303:Insect Vectors / Q000187:drug effects*; D007306:Insecticides / Q000032:analysis; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D008288:Malaria / Q000635:transmission; D029582:Meliaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D011679:Pupa / Q000187:drug effects; D014315:Triterpenes / Q000302:isolation & purification / Q000627:therapeutic use*
chemical_list: C529712:3beta,24,25-trihydroxycycloartane; D007306:Insecticides; D014315:Triterpenes; C489878:beddomeilactone