title: [The estimation of serum concentration of vascular endothelial growth factor in patients with non-small cell lung cancer].
abstract: Vascular endothelial growth factor (VEGF) is main angiogenic factor, which stimulates endothelial cells migration and proliferation. The extensive angiogenesis plays important role in tumor growth and metastasis.
  
  
  OBJECTIVE
  Analysis of serum concentrations of vascular endothelial growth factor in patients with non-small cell lung cancer depending on clinicopathologic findings.
  
  
  METHODS
  The study group consisted of 50 patients with non-small cell lung cancer (16 females and 34 males) ranging in age from 47 - 80 years (mean age 63 +/- 8.2). Serum VEGF concentration was evaluated by ELISA.
  
  
  RESULTS
  VEGF concentrations in serum did not differ significantly between groups of patients with different T-, N- and M-factor. Patients with inoperable tumor (IIIB and IV) had significantly higher serum VEGF concentrations compared with resected tumor (I-IlIA) and locally advanced cancer (IIIA).
  
  
  CONCLUSIONS
  Serum VEGF may be a marker of tumor progression in non-small cell lung cancer.
authors.affiliation: Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy, Katedra i Zakład Patobiochemii i Chemii Klinicznej. kopczynska@cm.umk.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Kopczyńska
authors.forename: Maciej
authors.initials: M
authors.lastname: Dancewicz
authors.forename: Janusz
authors.initials: J
authors.lastname: Kowalewski
authors.forename: Hanna
authors.initials: H
authors.lastname: Kardymowicz
authors.forename: Tomasz
authors.initials: T
authors.lastname: Tyrakowski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A