title: Matrix metalloproteinase-2 promoter polymorphism is associated with breast cancer in a Mexican population.
abstract: BACKGROUND
  Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity on matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism C>T transition at -1306 displayed a strong association with several cancers. Our study investigated whether or not the MMP-2 -1306C>T polymorphism contributed to the development of breast cancer (BC) in a Mexican population.
  
  
  METHODS
  90 patients with BC and 96 control subjects were analyzed to detect MMP-2 -1306C>T polymorphism.
  
  
  RESULTS
  The frequency of MMP-2 CC genotype was significantly higher in BC patients when compared with the control group (OR 2.15; 95% CI 1.1-4.1). MMP-2 CC genotype frequency was more pronounced in younger subjects (< or =50 years) at diagnosis (OR 2.66; 95% CI 1.04-6.96).
  
  
  CONCLUSIONS
  The data suggest that MMP-2 -1306C>T polymorphism strongly contributes to the development of BC in the population studied, especially among women 50 years old and younger.
authors.affiliation: School of Medicine, Universidad de Colima, Colima, Col., Mexico. ivan_delgado_enciso@ucol.mx
authors.forename: Iván
authors.initials: I
authors.lastname: Delgado-Enciso
authors.forename: Friedman R
authors.initials: FR
authors.lastname: Cepeda-Lopez
authors.forename: Elisa A
authors.initials: EA
authors.lastname: Monrroy-Guizar
authors.forename: Jose R
authors.initials: JR
authors.lastname: Bautista-Lam
authors.forename: Maricela
authors.initials: M
authors.lastname: Andrade-Soto
authors.forename: Gregorio
authors.initials: G
authors.lastname: Jonguitud-Olguin
authors.forename: Alejandrina
authors.initials: A
authors.lastname: Rodriguez-Hernandez
authors.forename: Aristoteles
authors.initials: A
authors.lastname: Anaya-Ventura
authors.forename: Luz M
authors.initials: LM
authors.lastname: Baltazar-Rodriguez
authors.forename: Martha
authors.initials: M
authors.lastname: Orozco-Ruiz
authors.forename: Alejandro D
authors.initials: AD
authors.lastname: Soriano-Hernandez
authors.forename: Iram P
authors.initials: IP
authors.lastname: Rodriguez-Sanchez
authors.forename: Angel
authors.initials: A
authors.lastname: Lugo-Trampe
authors.forename: Francisco
authors.initials: F
authors.lastname: Espinoza-Gomez
authors.forename: Martha L
authors.initials: ML
authors.lastname: Michel-Peregrina
mesh_terms: D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D017058:Mexican Americans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2