title: Developmental trajectory classes in substance use disorder etiology.
abstract: Three trajectory classes culminating in substance use disorder (SUD) were discerned in a longitudinal study of boys from ages 10-12 to 22 years. Neurobehavior disinhibition, parental SUD, socioeconomic status, and affiliation with deviant peers were measured at baseline. Approval of socially nonnormative behavior was measured at ages 10-12, 12-14, 16, and 19 years. Two high-risk trajectories, indicated by increasing approval of antisociality and progressive social maladjustment during adolescence (SUD rate = 72.7%) and stable high level of disturbance (SUD rate = 85%), were identified. Individual characteristics (neurobehavior disinhibition) in conjunction with contextual factors (low socioeconomic status, parental SUD, affiliation with deviant friends) promote approval of antisociality during adolescence and a high rate of SUD by young adulthood.
authors.affiliation: University of Pittsburgh, School of Pharmacy, Pittsburgh, PA 15261, USA. levent@pitt.edu
authors.forename: Levent
authors.initials: L
authors.lastname: Kirisci
authors.forename: Ralph
authors.initials: R
authors.lastname: Tarter
authors.forename: Ada
authors.initials: A
authors.lastname: Mezzich
authors.forename: Michael
authors.initials: M
authors.lastname: Vanyukov
mesh_terms: D000293:Adolescent; D000328:Adult; D000987:Antisocial Personality Disorder / Q000175:diagnosis / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000523:psychology; D002648:Child; D016241:Child of Impaired Parents / Q000523:psychology; D006801:Humans; D013287:Illicit Drugs; D007266:Inhibition, Psychological; D007604:Juvenile Delinquency / Q000523:psychology; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D010379:Peer Group; D010552:Personality Assessment; D010553:Personality Development; D012307:Risk Factors; D012959:Socioeconomic Factors; D013223:Statistics as Topic; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000523:psychology*
chemical_list: D013287:Illicit Drugs