title: [A case of multiple meningiomas: two lesions have different clinicopathological features, respectively].
abstract: A 60-year-old man presented with general convulsion. Computed tomographic (CT) scans and magnetic resonance (MR) imaging showed two meningiomas located at the bilateral frontal convex respectively. In spite of the similar tumor size, the left tumor only had marked peritumoral edema. Angiography showed that the left lesion was more amply supplied from the internal carotid artery than the right one was. These two tumors were totally resected. The left tumor adhered to the surrounding brain tissue more intensely than the right one. Both tumors were microscopically diagnosed as angiomatous meningioma. The left tumor cells have a stronger immunopositivity for VEGF than the right ones. We suggest that pial-blood supply, adhesion to brain tissue and VEGF expression influence the development of meningioma-associated peritumoral edema.
authors.affiliation: Department of Neurosurgery, Matsuyama Red Cross Hospital, 1 Bunkyo-cho, Matsuyama 790-8524, Japan.
authors.forename: Jumpei
authors.initials: J
authors.lastname: Oshita
authors.forename: Takashi
authors.initials: T
authors.lastname: Sogabe
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Maeda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sato
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kurisu
mesh_terms: D002533:Cerebral Angiography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D008579:Meningioma / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A