Effects of selenium and tellurium on the activity of selenoenzymes glutathione peroxidase and type I iodothyronine deiodinase, trace element thyroid level, and thyroid hormone status in rats.
Tellurium (Te) and selenium (Se) belong chemically to the VIa group of elements. Se represents an essential element closely related to thyroid function. Te has growing application in industrial processes. Little is known about the Te biological activity, particularly with respect to potential chemical interactions with Se-containing components in the organism. In this study, female Wistar rats (body weight: 115-120 g) received sodium selenite pentahydrate (10 mg/L) or sodium tellurite (9.4 mg/L) in drinking water for 6 wk. Additional groups of rats received their combination with zinc sulfate heptahydrate (515 mg/L). The stimulation of 5'-DI-I activity due to selenite (to 158%, p<0.01) or tellurite treatment (to 197%, p<0.01) was seen; however, no effect on glutathione peroxidase was demonstrated in this experiment. An elevation of T4, T3, and rT3 serum levels was measured in the Se+Te-treated group; T4 and rT3 levels were elevated in the Te+Zn-treated group. Te accumulates in the thyroid gland and influences the zinc thyroid level. Te treatment alone and in combination with Se or Zn decreased the iodine thyroid concentration to 65-70% of the control value. Further studies are needed to clarify the nature and effects of these events.
Eybl
Vladislav
V
Department of Pharmacology and Toxicology, Charles University Faculty of Medicine in Pilsen, and Charles University Hospital, Karlovarská 48, Pilsen, CZ-301 66, Czech Republic.
Kotyzová
Dana
D
Sýkora
Jindrich
J
Topolcan
Ondrej
O
Pikner
Richard
R
Mihaljevic
Martin
M
Brtko
Július
J
Glattre
Eystein
E
D000818:Animals; D001835:Body Weight / Q000502:physiology; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D007453:Iodide Peroxidase / Q000378:metabolism*; D009929:Organ Size / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000502:physiology*; D013691:Tellurium / Q000502:physiology*; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism*; D014131:Trace Elements / Q000378:metabolism
D013963:Thyroid Hormones; D014131:Trace Elements; D007453:Iodide Peroxidase; D005979:Glutathione Peroxidase; D012643:Selenium; D013691:Tellurium