title: [Diabetic nephropathy: glomerular filtration rate and estimated creatinine clearance].
abstract: OBJECTIVE
  To assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR).
  
  
  METHODS
  We analysed the GFR measure by Tc99m-DTPA method and the estimated by the Cockroft Gault formula, in 21 subjects with type 1 or type 2 diabetes.
  
  
  RESULTS
  There was a strong positive correlation between the two methods but the Cockroft Gault formula underestimated the GFR.
  
  
  CONCLUSIONS
  The formula gives a accurate estimates of GFR, when GFR is <100 ml/min/1,73 m2. Beside the underestimation, the formula could be used in the management of diabetic nephropathy because the repeated isotope assessments of renal function are impracticable.
authors.affiliation: Serviço Endocrinologia, Diabetes e Metabolismo, Hospitais da Universidade de Coimbra, Coimbra.
authors.forename: Joana
authors.initials: J
authors.lastname: Guimarães
authors.forename: Margarida
authors.initials: M
authors.lastname: Bastos
authors.forename: Miguel
authors.initials: M
authors.lastname: Melo
authors.forename: Manuela
authors.initials: M
authors.lastname: Carvalheiro
mesh_terms: D003404:Creatinine / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D003404:Creatinine