[Interleukin-6 implication in prostate cancer].
Interleukin-6 (IL-6) is secreted in great quantity in prostatic tumoral glandular tissue with a significant higher rate in hormono-refractory phase. Importance of IL-6 dependent mechanism in prostate cancer progression is well argued. IL-6 seems to be implicated in androgen receptor activation in lack of steroid ligand, apoptosis decrease and increase of invasive capacity and angiogenesis via three major signaling pathways: MAPK, STAT3 and PI3K-Akt. As AR is a key factor of prostate cancer progression, IL-6 implication in this activation underlines IL-6 importance in prostate cancer. IL-6 also induces neuroendocrine differentiation. This phenomenon received a detailed attention because it would take part in pathogenicity and progression of prostate cancer. Although complementary studies seem necessary, taking into account its strong implication in prostate cancer progression, IL-6 seems to be a new potential therapeutic target of prostate cancer.
Cabrespine
Aurélie
A
Service de thérapie cellulaire et d'hématologie clinique adultes, Pavillon Villemin-Pasteur, Hôtel-Dieu boulevard Léon-Malfreyt, 63058 Clermont-Ferrand. acabrespine@chu-clermontferrand.fr
Bay
Jacques-Olivier
JO
Verrelle
Pierre
P
Morel
Laurent
L
D017209:Apoptosis / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology*; D008297:Male; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009363:Neoplasm Proteins / Q000502:physiology*; D009490:Neurosecretory Systems / Q000166:cytology / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism; D019947:Receptors, Interleukin-6 / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism
D015850:Interleukin-6; D009363:Neoplasm Proteins; D011944:Receptors, Androgen; D019947:Receptors, Interleukin-6; D050796:STAT3 Transcription Factor; D051057:Proto-Oncogene Proteins c-akt; D020928:Mitogen-Activated Protein Kinases