The effect of ultrapure dialysate on improving renal anemia.
BACKGROUND
Renal anemia is a very serious problem in hemodialysis patients. In this regard, the investigation was focused on whether ultrapure dialysate could improve renal anemia and the mechanism of renal anemia.


METHODS
Ultrapure dialysate was used over a 2 years period for 61 patients on maintenance hemodialysis. During this period, the changes in renal anemia and red blood cell life span were investigated. The changes in the latter were evaluated using the creatine concentration in red blood cell.


RESULTS
The hemoglobin concentration, RBC count, and hematocrit concentration before the use of the ultrapure dialysate were 9.1 +/- 0.2 g/dL, 309.9 +/- L7.2 x 10(4)/microL, and 28.8 +/- 0.6%, respectively. These values significantly increased to 10.2 +/- 0.1 g/dL, 349.7 +/- 5.6 x 10(4)/microL, and 32.6 +/- 0.3%, respectively, after 2 years of ultrapure dialysate use. The increase in reticulocyte count indicated enhanced erythropoiesis by ultrapure dialysate. The red blood cell life span evaluated by creatine concentration in red blood cell was also prolonged after the use of ultrapure dialysate.


CONCLUSIONS
Ultrapure dialysate is considered to improve the renal anemia of dialysis patients by promoting erythropoiesis and prolonging red blood cell life span.
Go
Ishun
I
Department of Urology, Osaka City University, Graduate School of Medicine, Japan. igo@med.osaka-cu.ac.jp
Takemoto
Yoshiaki
Y
Tsuchida
Kenji
K
Sugimura
Kazunobu
K
Nakatani
Tatsuya
T
D000368:Aged; D000740:Anemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology*; D002097:C-Reactive Protein / Q000378:metabolism; D003401:Creatine / Q000097:blood; D015314:Dialysis Solutions / Q000737:chemistry / Q000592:standards / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004906:Erythrocyte Count; D004920:Erythropoiesis / Q000502:physiology; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D005293:Ferritins / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D008137:Longitudinal Studies; D008297:Male; D006435:Renal Dialysis
D015314:Dialysis Solutions; D006454:Hemoglobins; D004921:Erythropoietin; D002097:C-Reactive Protein; D005293:Ferritins; D003401:Creatine