title: The interleukin-1 receptor antagonist gene and the inhibitor of kappa B-like protein gene polymorphisms are not associated with myocardial infarction in Slovene population with type 2 diabetes.
abstract: In this study we investigated the association of the interleukin-1 receptor antagonist gene variable number tandem repeat (IL1RN VNTR) polymorphism and of the inhibitor of kappa B-like protein (IKBL) gene polymorphism with myocardial infarction (MI) in a group of patients with type 2 diabetes. The IL1RN VNTR and the IKBL+ 738T > C gene polymorphisms were tested in 374 Caucasians: 151 cases with MI and 223 subjects with no history of coronary artery disease. The IL1RN VNTR polymorphism was not a risk factor for MI in Caucasians with type 2 diabetes (genotype 22 vs. the rest: odds ratio (OR) 1.6; 95% confidence interval (CI) = 0.8-3.5; p = 0.2). We also failed to demonstrate that IKBL+ 738T > C gene polymorphism was associated with MI in patients with type 2 diabetes (OR = 0.9; 95% CI = 0.3-2.6; p = 0.9). We provide evidence that the IL1RN VNTR and the IKBL + 738T > C gene polymorphisms are not risk factors for MI in Caucasians with type 2 diabetes.
authors.affiliation: Department of Internal Medicine, General Hospital "Izola", Izola, Slovenia.
authors.forename: Stojan
authors.initials: S
authors.lastname: Kariz
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Milutinović
authors.forename: Dejan
authors.initials: D
authors.lastname: Bregar
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Terzić
authors.forename: Rifet
authors.initials: R
authors.lastname: Terzić
authors.forename: Luca
authors.initials: L
authors.lastname: Lovrecić
authors.forename: Magdalena
authors.initials: M
authors.lastname: Herova
authors.forename: Helena
authors.initials: H
authors.lastname: Hruskovicova
authors.forename: Borut
authors.initials: B
authors.lastname: Peterlin
authors.forename: Danijel
authors.initials: D
authors.lastname: Petrovic
authors.forename: Ruda
authors.initials: R
authors.lastname: Zorc-Pleskovic
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D017524:Slovenia / Q000453:epidemiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000949:Histocompatibility Antigens Class II; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; C120111:NFKBIL1 protein, human