title: Early inflammatory response in acute pancreatitis is little affected by body mass index.
abstract: OBJECTIVE
  Obesity is a known risk factor for severe acute pancreatitis (AP), but the mechanism by which it affects the severity of AP is not fully understood. The main objective of this study was to investigate the relationship between obesity and inflammatory markers in AP.
  
  
  METHODS
  Thirty patients with AP who developed organ failure (Group I) and 87 patients with AP who survived without organ failure (Group II) were studied. Patients' height and weight were measured at admission for calculation of body mass index (BMI). Blood samples were taken at admission for measurement of plasma interleukin (IL)-1beta, IL-6, IL-10, IL-1 receptor antagonist, procalcitonin, C-reactive protein (CRP) and monocyte human leucocyte antigen (HLA)-DR expression.
  
  
  RESULTS
  Group I patients had higher BMI values (median 26.2 kg/m2) than Group II patients (25.2 kg/m2), p =0.033. Both CRP values and monocyte HLA-DR expression showed a significant correlation with BMI (Spearman's rank correlation r=0.32, p =0.003 and r= -0.33, p = 0.002, respectively). The correlation between BMI and monocyte HLA-DR expression was significant in Group II patients (r = -0.34, p =0.002) but not in Group I patients (r = -0.02, p >0.05). There was no correlation between BMI and IL-1beta, IL-6, IL-10, IL-1 receptor antagonist or procalcitonin.
  
  
  CONCLUSIONS
  BMI did not affect either proinflammatory or anti-inflammatory cytokine levels in early AP. However, in patients with mild AP, BMI correlated positively with CRP levels and inversely with monocyte HLA-DR expression, which might reflect an amplified inflammatory response in these patients. Taken together, acute inflammatory response in AP, which ultimately determines the severity of AP, was little affected by BMI.
authors.affiliation: Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland. panu.mentula@saunalahti.fi
authors.forename: Panu
authors.initials: P
authors.lastname: Mentula
authors.forename: Marja-Leena
authors.initials: ML
authors.lastname: Kylänpää
authors.forename: Esko
authors.initials: E
authors.lastname: Kemppainen
authors.forename: Heikki
authors.initials: H
authors.lastname: Repo
authors.forename: Pauli
authors.initials: P
authors.lastname: Puolakkainen
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000473:pathology*; D011498:Protein Precursors / Q000097:blood; D013223:Statistics as Topic
chemical_list: C000606589:CALCA protein, human; D006684:HLA-DR Antigens; D018836:Inflammation Mediators; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide