Expanding the microcomedone theory and acne therapeutics: Propionibacterium acnes biofilm produces biological glue that holds corneocytes together to form plug.
The Propionibacterium acnes biofilm has previously been shown to exist via genomic studies and to make a biological glue which allows for adherence to follicular walls. This gylcocalyx polymer secreted by P acnes also finds its way into sebum composition where it causes the adhesiveness of keratinocytes leading to comedones. An appreciation of P acnes biofilms and secretions has implications in immunogenicity of the organism, clinical course of acne, and therapy for comedonal and inflammatory acne.
Burkhart
Craig G
CG
University of Toledo School of Medicine, Sylvania, Ohio, USA.
Burkhart
Craig N
CN
D000152:Acne Vulgaris / Q000188:drug therapy / Q000382:microbiology* / Q000503:physiopathology*; D018441:Biofilms / Q000187:drug effects; D003879:Dermatologic Agents / Q000494:pharmacology / Q000627:therapeutic use; D019276:Glycocalyx / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000502:physiology; D011425:Propionibacterium acnes / Q000472:pathogenicity / Q000502:physiology*; D014014:Tissue Adhesives
D003879:Dermatologic Agents; D014014:Tissue Adhesives