Species-dependent plasma metabolism of the ester compound daidzein 7,4'di-succinic acid mon-ester-O-ethoxy (DZ5).
Daidzein 7,4'di-succinic acid mon-ester-O-ethoxy (DZ5) is an ester-containing compound, which was recently synthesized. The objective of this study was to determine the hydrolysis rate of DZ5 in blood from the rat and the dog. The data showed that the hydrolysis rate of DZ5 in plasma was much more rapid in rats than in dogs following intravenous administration. Moreover, similar results were observed after in vitro incubation of DZ5 in the rat or dog plasma. The findings suggested that plasma esterases in the rat plasma have higher activity than in the dog and plasma metabolism of DZ5 is species-dependent.
Wang
Shujun
S
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China. xiaohu6408_cn@sina.com
Yang
Jingyu
J
Peng
Ying
Y
Zou
Yu
Y
Xiang
Huixin
H
Yao
Huimin
H
Chen
Jimin
J
Bi
Dianzhou
D
Yao
Jianhua
J
D000818:Animals; D001800:Blood Specimen Collection; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D007202:Indicators and Reagents; D007529:Isoflavones / Q000097:blood* / Q000493:pharmacokinetics; D010949:Plasma / Q000378:metabolism*; D051381:Rats; D015203:Reproducibility of Results; D013045:Species Specificity; D013056:Spectrophotometry, Ultraviolet; D013386:Succinates / Q000097:blood* / Q000493:pharmacokinetics
C515219:7,4'-disuccinic acid monoester-O-ethoxydaidzein; D007202:Indicators and Reagents; D007529:Isoflavones; D013386:Succinates; C004742:daidzein