Propionibacterium endocarditis: a case series from the International Collaboration on Endocarditis Merged Database and Prospective Cohort Study.
Propionibacterium species are occasionally associated with serious systemic infections such as infective endocarditis. In this study, we examined the clinical features, complications and outcome of 15 patients with Propionibacterium endocarditis using the International Collaboration on Endocarditis Merged Database (ICE-MD) and Prospective Cohort Study (ICE-PCS), and compared the results to 28 cases previously reported in the literature. In the ICE database, 11 of 15 patients were male with a mean age of 52 y. Prosthetic valve endocarditis occurred in 13 of 15 cases and 3 patients had a history of congenital heart disease. Clinical findings included valvular vegetations (9 patients), cardiac abscesses (3 patients), congestive heart failure (2 patients), and central nervous system emboli (2 patients). Most patients were treated with beta-lactam antibiotics alone or in combination for 4 to 6 weeks. 10 of the 15 patients underwent valve replacement surgery and 2 patients died. Similar findings were noted on review of the literature. The results of this paper suggest that risk factors for Propionibacterium endocarditis include male gender, presence of prosthetic valves and congenital heart disease. The clinical course is characterized by complications such as valvular dehiscence, cardiac abscesses and congestive heart failure. Treatment may require a combination of medical and surgical therapy.
Lalani
Tahaniyat
T
Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Cube 7545, Durham, NC 27710 USA. lalan002@mc.duke.edu
Person
Anna K
AK
Hedayati
Susan S
SS
Moore
Laura
L
Murdoch
David R
DR
Hoen
Bruno
B
Peterson
Gail
G
Shahbaz
Hasan
H
Raoult
Didier
D
Miro
Jose M
JM
Olaison
Lars
L
Snygg-Martino
Ulrika
U
Suter
Fredy
F
Spelman
Dennis
D
Eykyn
Susannah
S
Strahilevitz
Jacob
J
Van der Meer
Jan T
JT
Verhagen
Dominique
D
Baloch
Khaula
K
Abrutyn
Elias
E
Cabell
Christopher H
CH
D000193:Actinomycetales Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D016208:Databases, Factual; D004697:Endocarditis, Bacterial / Q000150:complications / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D006331:Heart Diseases / Q000150:complications / Q000151:congenital / Q000453:epidemiology / Q000382:microbiology; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006801:Humans; D007391:International Cooperation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011424:Propionibacterium / Q000145:classification / Q000302:isolation & purification; D011446:Prospective Studies; D016459:Prosthesis-Related Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D012307:Risk Factors; D015996:Survival Rate