Clinical stage-depending decrease of NK cell activity in multiple myeloma patients.
Natural killer cells, as an important subpopulation of cells of the innate immune system have an essential role in defense of the rise and spread of malignancy. These cells have a CD3-CD16 + CD56+ phenotype and they are functionally defined by their ability to lyses tumor cells. We here show that decrease of NK cell activity was significantly associated with advanced clinical stage, increased lactate dehydrogenase (LDH), percentage infiltration of bone marrow with plasma cells, and beta-2 microglobulin. The patients with higher NK cell activity at presentation after receiving VAD protocol have better cumulative survival in comparison with those with low NK cell activity.
Jurisic
Vladimir
V
Pathophysiology Department, School of Medicine, University of Kragujevac, Kragujevac 34 000, Serbia. vdvd@mailcity.com
Srdic
Tatjana
T
Konjevic
Gordana
G
Markovic
Olivera
O
Colovic
Milica
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D003907:Dexamethasone / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007136:Immunoglobulins / Q000097:blood; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009367:Neoplasm Staging; D018709:Statistics, Nonparametric; D014750:Vincristine / Q000627:therapeutic use; D001613:beta 2-Microglobulin / Q000097:blood
D007136:Immunoglobulins; D001613:beta 2-Microglobulin; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D007770:L-Lactate Dehydrogenase