title: [The role of visceral receptors in the mechanisms of neuroimmune interactions in mammalian small intestine].
abstract: Exogenous administration of mast cell degranulation products into blood as well as their endogenous release induced by compound 48/80 or repeated egg albumin administration to sensitized rats proved to increase activity of mesenteric afferent nerve fibers in the small intestine. In addition, the primary contact with a foreign protein triggered a cascade of chemical processes mobilizing antioxidant systems and increasing nitric oxide production in the small intestinal tissues. Interleukin-1beta or Escherichia coli lipopolysaccharide injections also had a long-term stimulating effect on intestinal receptors. Indometacin inhibited the effects induced by the bacterial endotoxin and interleukin-1beta. The obtained data suggest that small intestinal interoceptors can monitor chemical environment and modulate body's responses to foreign antigens. Interleukins-1beta acts as a signal transmitter between immune cells and interoceptors, which is mediated by the production of secondary signal substances, in particular, prostaglandin-2 and histamine.
authors.forename: L V
authors.initials: LV
authors.lastname: Filippova
authors.forename: A D
authors.initials: AD
authors.lastname: Nozdrachev
mesh_terms: D000818:Animals; D002415:Cats; D015550:Cell Degranulation / Q000187:drug effects / Q000276:immunology; D053583:Interleukin-1beta / Q000276:immunology / Q000494:pharmacology; D007421:Intestine, Small / Q000276:immunology* / Q000294:innervation* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism; D008643:Mesentery / Q000276:immunology* / Q000294:innervation* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology*
chemical_list: D053583:Interleukin-1beta; D008070:Lipopolysaccharides