Evaluation and differential diagnosis of marked, persistent eosinophilia.
Hypereosinophilic syndromes (HES) are a group of heterogeneous disorders many of which remain ill-defined. By definition, the HES must be distinguished from other disorders with persistently elevated eosinophilia with a defined cause. Although marked eosinophilia worldwide is most commonly caused by helminth (worm) infections, the diagnostic approach must include noninfectious (nonparasitic) causes of marked eosinophilia as well.
Nutman
Thomas B
TB
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room B1-03, 4 Center Drive, Bethesda, MD 20892-0425, USA. tnutman@niaid.nih.gov
D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D004804:Eosinophils / Q000502:physiology*; D006801:Humans