Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation.
The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF).
Raiber
Eun-Ang
EA
Centre for Molecular Drug Design, Cockcroft Building, University of Salford, Salford, UK.
Wilkinson
James A
JA
Manetti
Fabrizio
F
Botta
Maurizio
M
Deakin
Jon
J
Gallagher
John
J
Lyon
Malcolm
M
Ducki
Sylvie W
SW
D000818:Animals; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D003198:Computer Simulation; D004285:Dogs; D006493:Heparin / Q000494:pharmacology*; D006497:Heparan Sulfate / Q000737:chemistry / Q000494:pharmacology*; D017228:Hepatocyte Growth Factor / Q000378:metabolism*; D008958:Models, Molecular; D018716:Molecular Mimicry; D015394:Molecular Structure; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D019859:Proto-Oncogene Proteins c-met; D017978:Receptors, Growth Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism*
D006493:Heparin; D006497:Heparan Sulfate; D017228:Hepatocyte Growth Factor; D011518:Proto-Oncogene Proteins; D019859:Proto-Oncogene Proteins c-met; D017978:Receptors, Growth Factor; C491743:MET protein, human