Identification of a novel allele HLA-DQB1*0622.
A novel human leukocyte antigen-DQ allele, DQB1*0622, was identified in a bone marrow transplantation candidate. DQB1*0622 differs from DQB1*0609 by two nucleotide differences in exon 2, position 122 (A-->T) and 177 (A-->G). The difference at position 122 resulted in an amino acid change (Tyrosine to Phenylalanine). However, the difference at position 177 did not cause any amino acid change.
Chang
Y
Y
Department of Pathology and Laboratory Medicine, All Children's Hospital, St. Petersburg, FL 33701, USA. changy@allkids.org
Fan
T X
TX
Santana
Z
Z
Day
N K
NK
D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D005091:Exons; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008969:Molecular Sequence Data; D020125:Mutation, Missense
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen