title: The pharmacokinetics and metabolism of ivermectin in domestic animal species.
abstract: The pharmacokinetic properties of drugs are closely related to their pharmacological efficacy. The kinetics of ivermectin are characterised, in general terms, by a slow absorption process, a broad distribution in the organism, low metabolism, and slow excretion. The kinetics vary according to the route of administration, formulation, animal species, body condition, age, and physiological status, all of which contribute to differences in drug efficacy. Characterisation of ivermectin kinetics can be used to predict and optimise the value of the parasiticide effects and to design programmes for parasite control. This article reviews the pharmacokinetics of ivermectin in several domestic animal species.
authors.affiliation: Department of Biomedical Sciences, Veterinary Faculty, University of Leon, Spain. agonc@unileon.es
authors.forename: Aránzazu
authors.initials: A
authors.lastname: González Canga
authors.forename: Ana M
authors.initials: AM
authors.lastname: Sahagún Prieto
authors.forename: M
authors.initials: M
authors.lastname: José Diez Liébana
authors.forename: Nélida Fernández
authors.initials: NF
authors.lastname: Martínez
authors.forename: Matilde Sierra
authors.initials: MS
authors.lastname: Vega
authors.forename: Juan J García
authors.initials: JJ
authors.lastname: Vieitez
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000378:metabolism*; D000977:Antiparasitic Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002415:Cats / Q000378:metabolism; D002417:Cattle / Q000097:blood; D004285:Dogs / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006041:Goats / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects* / Q000502:physiology; D007559:Ivermectin / Q000493:pharmacokinetics*; D008657:Metabolic Clearance Rate / Q000502:physiology*; D012756:Sheep / Q000378:metabolism; D013045:Species Specificity; D013552:Swine / Q000378:metabolism
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin