title: Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea.
abstract: Many patients with rosacea are unable to tolerate extended treatment periods with topical agents because of the unusually high skin sensitivity that often accompanies rosacea. Kinetin (N(6)-furfuryladenine) is a plant cytokinin that reportedly helps restore skin barrier function and may be useful to ameliorate the signs and symptoms of rosacea. The purpose of this open-label study was to determine the tolerance and efficacy of twice-daily application of kinetin 0.1% lotion for improving the signs and symptoms of mild to moderate facial rosacea. Subjects applied kinetin 0.1% lotion twice daily to the face, with daily use of a sunscreen of sun protection factor 30. Subjects were evaluated at baseline and at 4-week intervals for 12 weeks to assess efficacy and tolerance. Results of this study suggest that kinetin 0.1% lotion is a well-tolerated moisturizing lotion option for subjects with mild to moderate inflammatory rosacea.
authors.affiliation: Department of Dermatology, University of California, Irvine, Irvine, CA 92697-2400, USA. jjwu@uci.edu
authors.forename: J J
authors.initials: JJ
authors.lastname: Wu
authors.forename: G D
authors.initials: GD
authors.lastname: Weinstein
authors.forename: G J
authors.initials: GJ
authors.lastname: Kricorian
authors.forename: T
authors.initials: T
authors.lastname: Kormeili
authors.forename: J L
authors.initials: JL
authors.lastname: McCullough
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D003879:Dermatologic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004643:Emollients / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007701:Kinetin / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012393:Rosacea / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D004643:Emollients; D007701:Kinetin