The effect of atrial septostomy on the concentration of brain-type natriuretic peptide in patients with idiopathic pulmonary arterial hypertension.
Atrial septostomy has improved haemodynamics and clinical symptoms in selected patients with idiopathic pulmonary arterial hypertension. We found that, in 5 patients with idiopathic pulmonary arterial hypertension, septostomy resulted in decreased levels of brain-type natriuretic peptide, and improvement in symptoms of cardiac failure, suggesting that serial measurements of the peptide may have clinical utility.
O'Byrne
Michael L
ML
Columbia University College of Physicians and Surgeons New York, New York, USA.
Rosenzweig
Erika S Berman
ES
Barst
Robyn J
RJ
D000293:Adolescent; D000328:Adult; D005260:Female; D006325:Heart Atria / Q000601:surgery; D006346:Heart Septum / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000601:surgery*; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*
D020097:Natriuretic Peptide, Brain