title: GLIOGENE an International Consortium to Understand Familial Glioma.
abstract: Evidence for familial aggregation of glioma has been documented in both case-control and cohort studies and occurs apart from the well-described rare inherited genetic syndromes involving glioma: neurofibromatosis type 1 and 2, tuberous sclerosis, Turcot's syndrome, and Li-Fraumeni syndrome. Nonsyndromic glioma families have been studied but no genes have been identified in the two published linkage studies of familial glioma probably due to the small number of families. Because glioma is a rare but devastating cancer, and a family history of glioma has been observed in approximately 5% of the cases, we initiated an international consortium to identify glioma families not affected by syndromes to better understand the inherited factors related to this disease. The international consortium GLIOGENE is an acronym for "glioma gene" and includes 15 research groups in North America, Europe, and Israel to study familial glioma. The overarching goal is to characterize genes in glioma families using a genome-wide single-nucleotide polymorphism approach and conducting linkage analysis to identify new genomic regions or loci that could harbor genes important for gliomagenesis. Here, we review the rationale for studying familial glioma and our proposed strategy for the GLIOGENE study.
authors.affiliation: Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Unit 1340, P.O. Box 301439, Houston, TX 77230-1439, USA.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Malmer
authors.forename: Phyllis
authors.initials: P
authors.lastname: Adatto
authors.forename: Georgina
authors.initials: G
authors.lastname: Armstrong
authors.forename: Jill
authors.initials: J
authors.lastname: Barnholtz-Sloan
authors.forename: Jonine L
authors.initials: JL
authors.lastname: Bernstein
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Claus
authors.forename: Faith
authors.initials: F
authors.lastname: Davis
authors.forename: Richard
authors.initials: R
authors.lastname: Houlston
authors.forename: Dora
authors.initials: D
authors.lastname: Il'yasova
authors.forename: Robert
authors.initials: R
authors.lastname: Jenkins
authors.forename: Christoffer
authors.initials: C
authors.lastname: Johansen
authors.forename: Rose
authors.initials: R
authors.lastname: Lai
authors.forename: Ching
authors.initials: C
authors.lastname: Lau
authors.forename: Bridget
authors.initials: B
authors.lastname: McCarthy
authors.forename: Hanne
authors.initials: H
authors.lastname: Nielsen
authors.forename: Sara H
authors.initials: SH
authors.lastname: Olson
authors.forename: Siegal
authors.initials: S
authors.lastname: Sadetzki
authors.forename: Sanjay
authors.initials: S
authors.lastname: Shete
authors.forename: Fredrik
authors.initials: F
authors.lastname: Wiklund
authors.forename: Margaret
authors.initials: M
authors.lastname: Wrensch
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.forename: Melissa
authors.initials: M
authors.lastname: Bondy
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D015331:Cohort Studies; D005060:Europe; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005910:Glioma / Q000235:genetics*; D006801:Humans; D007390:International Agencies; D007557:Israel; D009656:North America; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide
chemical_list: D005819:Genetic Markers