title: Amino-caprolactam derivatives as gamma-secretase inhibitors.
abstract: A series of amino-caprolactam sulfonamides were developed from a screening hit. Compounds with good in vitro and in vivo gamma-secretase activity are reported.
authors.affiliation: Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. parkerm@BMS.com
authors.forename: Michael F
authors.initials: MF
authors.lastname: Parker
authors.forename: Joanne J
authors.initials: JJ
authors.lastname: Bronson
authors.forename: Donna M
authors.initials: DM
authors.lastname: Barten
authors.forename: Jason A
authors.initials: JA
authors.lastname: Corsa
authors.forename: Wengsheng
authors.initials: W
authors.lastname: Du
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Felsenstein
authors.forename: Valerie L
authors.initials: VL
authors.lastname: Guss
authors.forename: Darcy
authors.initials: D
authors.lastname: Izzarelli
authors.forename: Alice
authors.initials: A
authors.lastname: Loo
authors.forename: Kate E
authors.initials: KE
authors.lastname: McElhone
authors.forename: Larry R
authors.initials: LR
authors.lastname: Marcin
authors.forename: Ramesh
authors.initials: R
authors.lastname: Padmanabha
authors.forename: Roger
authors.initials: R
authors.lastname: Pak
authors.forename: Craig T
authors.initials: CT
authors.lastname: Polson
authors.forename: Jeremy H
authors.initials: JH
authors.lastname: Toyn
authors.forename: Sam
authors.initials: S
authors.lastname: Varma
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Victoria
authors.initials: V
authors.lastname: Wong
authors.forename: Ming
authors.initials: M
authors.lastname: Zheng
authors.forename: Susan B
authors.initials: SB
authors.lastname: Roberts
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D002209:Caprolactam / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D002209:Caprolactam; D053829:Amyloid Precursor Protein Secretases