title: Pulmonary lymphoma developed during long-term methotrexate therapy for psoriasis.
abstract: Low dose weekly administration of methotrexate has been thought to be effective for both rheumatoid arthritis (RA) and psoriasis. However, there is a possibility that methotrexate therapy may be oncogenic. This report presents a case of pulmonary lymphoma developed during long-term methotrexate therapy for psoriasis. Physicians should be aware that Epstein-Barr virus-associated lymphoproliferative disorders that occur during treatment with methotrexate are not specific to patients with RA.
authors.affiliation: Department of Respiratory Medicine, International Medical Center of Japan Hospital, Tokyo, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Suzuki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirano
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Daisuke
authors.initials: D
authors.lastname: Matsubara
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kubota
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Takeda
authors.forename: Haruhito
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kudo
mesh_terms: D000328:Adult; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008223:Lymphoma / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D011379:Prognosis; D011565:Psoriasis / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate