In vivo long-term effects of retinoic acid exposure in utero on induced hyperplastic epidermal foci in murine skin.
Adult Naval Medical Research Institute (NMRI) mice, after prenatal exposure to retinoic acid (RA), were treated with a standard two-stage skin carcinogenesis regime to characterize hyperplastic epidermal foci that precede the appearance of cutaneous papillomas, and to investigate the in vivo long-term action of RA on adult mouse skin treated with DMBA (7,12 dimethyl benz[a]anthracene) and TPA (12-O-tetradecanoylphorbol 13-acetate). The results demonstrate that RA administered to pregnant mice had a long-term inhibitory action on the cell differentiation and development of hyperplastic lesions occurring prior to cancer on the adult skin of their offspring as well as a stimulatory effect on cell proliferation of these hyperplastic lesions.
García-Fernández
Rosa A
RA
Histology and Pathological Anatomy Section, Department of Animal Medicine and Surgery, Faculty of Veterinary Science, University of Madrid (UCM), Madrid, Spain.
Pérez-Martínez
Claudia
C
Espinosa-Alvarez
Javier
J
García-Iglesias
Maria J
MJ
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002454:Cell Differentiation / Q000187:drug effects*; D004195:Disease Models, Animal; D005260:Female; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012867:Skin / Q000166:cytology / Q000187:drug effects*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D014212:Tretinoin / Q000008:administration & dosage / Q000494:pharmacology*
D002273:Carcinogens; D007641:Keratolytic Agents; D014212:Tretinoin; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate