title: Orthokeratology-related infectious keratitis: a case series.
abstract: OBJECTIVE
  To describe five patients who developed infectious keratitis after the use of overnight orthokeratology contact lenses.
  
  
  METHODS
  Retrospective case report of five patients with infectious keratitis seen in Singapore National Eye Centre between 2001 and 2006.
  
  
  RESULTS
  Five children between the ages of 9 and 14 years, who wore their lenses for an average of 1.5 months before developing orthokeratology-related infectious keratitis, were seen and treated at the Singapore National Eye Centre. All five patients had cultures that were positive for Pseudomonas aeruginosa. They were treated with fortified cefazolin (50 mg/mL) and gentamicin (14 mg/mL) and responded well, with resolution of the infectious keratitis. Although most patients had a best-corrected visual acuity of 20/40 or better after the resolution of the acute infection, they all showed a central or paracentral residual scar.
  
  
  CONCLUSIONS
  Because of the safety issues involved, orthokeratology should be used with caution in children.
authors.affiliation: Singapore National Eye Centre, Singapore Eye Research Institute, Singapore.
authors.forename: Elaine W L
authors.initials: EW
authors.lastname: Chee
authors.forename: Lim
authors.initials: L
authors.lastname: Li
authors.forename: Donald
authors.initials: D
authors.lastname: Tan
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002437:Cefazolin / Q000627:therapeutic use; D002648:Child; D002921:Cicatrix / Q000209:etiology; D003261:Contact Lenses / Q000009:adverse effects*; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007634:Keratitis / Q000150:complications / Q000382:microbiology* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000209:etiology*; D012030:Refractive Errors / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002437:Cefazolin