title: Late enhancement using multidetector row computer tomography: a feasibility study with low dose 80 kV protocol.
abstract: OBJECTIVE
  Detecting stenoses of coronary arteries with multidetector row computer tomography (MDCT) is a well feasible non-invasive method. However, there is still the problem of deciding whether a stenosis is hemodynamically relevant or not. Objective of the present study was to validate the feasibility of a low dose protocol for MDCT using 80 kV for detecting late enhancement.
  
  
  RESULTS
  Using a Alderson-Rando Phantom evaluation of the effective dose of this LE protocol was performed. Ten patients (six male, four female, mean age 61) with known coronary artery disease and scheduled for a conventional coronary angiogram in our facility were subsequently recruited. All patients underwent CT-angiography (CTA) 1 day prior to magnetic resonance imaging. Five minutes after the application of 100ml contrast agent for the CTA scan, a low dose late enhancement scan (80 kV, 400 mA s maximum, ECG pulsed scan, 64 mm x 0.6mm collimation, 0.33 s tube rotation) was performed. Phantom dose measurements showed an effective dose for this protocol of 1.19 mSv (male) and 1.61 mSv (female). Fifty-six percent (5/9) of the patients showed a late enhancement on the MRI scan. Three transmural late enhancements and all four negative findings were correctly identified by CT. This represents a sensitivity of 78% (3/5), specificity of 100% (3/3), NPV of 100% (4/4) and a PPV of 97%.
  
  
  CONCLUSIONS
  We were able to show that the low dose protocol is feasible and, furthermore, preliminary results look promising.
authors.affiliation: Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany.
authors.forename: Anja J
authors.initials: AJ
authors.lastname: Reimann
authors.forename: Axel
authors.initials: A
authors.lastname: Kuettner
authors.forename: Bernhard
authors.initials: B
authors.lastname: Klumpp
authors.forename: Martin
authors.initials: M
authors.lastname: Heuschmid
authors.forename: Felix
authors.initials: F
authors.lastname: Schumacher
authors.forename: Matthias
authors.initials: M
authors.lastname: Teufel
authors.forename: Torsten
authors.initials: T
authors.lastname: Beck
authors.forename: Christof
authors.initials: C
authors.lastname: Burgstahler
authors.forename: Steffen
authors.initials: S
authors.lastname: Schröder
authors.forename: Claus D
authors.initials: CD
authors.lastname: Claussen
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Kopp
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005240:Feasibility Studies; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007479:Iopamidol / Q000031:analogs & derivatives; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol; D019786:Gadolinium DTPA