In vivo effect of casticin on acute inflammation.
OBJECTIVE
To investigate the anti-inflammatory effect of casticin of Fructus Viticis.


METHODS
Observations were made on the anti-inflammatory effect of casticin in the models of acute inflammation in vivo.


RESULTS
Casticin inhibited significantly xylene-induced mouse ear edema, egg albumen-induced rat paw edema and acetic acid-induced mouse vascular permeability.


CONCLUSIONS
Casticin has significant anti-inflammatory effect on acute inflammation, which is probably related to the inhibition of the inflammation factors. Casticin is the effective constituent contributing to the anti-inflammatory effect of Fructus Viticis.
Lin
Shan
S
Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province 350003, China.
Zhang
Hong
H
Han
Ting
T
Wu
Jin-Zhong
JZ
Rahman
Khalid
K
Qin
Lu-Ping
LP
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D004487:Edema / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; C054133:casticin