title: Synthesis and biological evaluation of rigid polycyclic derivatives of the Diels-Alder adduct tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione.
abstract: Part of our research program concentrates on the discovery of new bioactive compounds prepared either by total synthesis or molecular transformation of compounds with bioactivity profiles. In this work we have focused our interest on chemical transformations of the Diels-Alder adduct tricyclo[6.2.1.0(2,7)]undeca-4,9-dien-3,6-dione in order to obtain cage-like compounds and derivatives, followed by an evaluation of their biological activity.
authors.affiliation: Department of Chemistry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil. megumi@nin.ufms.br
authors.forename: Felicia Megumi
authors.initials: FM
authors.lastname: Ito
authors.forename: Jacqueline Marques
authors.initials: JM
authors.lastname: Petroni
authors.forename: Dênis Pires
authors.initials: DP
authors.lastname: de Lima
authors.forename: Adilson
authors.initials: A
authors.lastname: Beatriz
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Marques
authors.forename: Manoel Odorico
authors.initials: MO
authors.lastname: de Moraes
authors.forename: Letícia Veras
authors.initials: LV
authors.lastname: Costa-Lotufo
authors.forename: Raquel Carvalho
authors.initials: RC
authors.lastname: Montenegro
authors.forename: Hemerson Iury Ferreira
authors.initials: HI
authors.lastname: Magalhães
authors.forename: Cláudia do O
authors.initials: Cdo O
authors.lastname: Pessoa
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
chemical_list: D011083:Polycyclic Compounds