Cassane furanoditerpenoids from the seed kernels of Caesalpinia bonduc from Thailand.
Three new cassane furanoditerpenoids ( 1- 3), together with 13 known cassane diterpenes ( 4- 16), were isolated from the EtOAc extract of the seed kernels of Caesalpinia bonduc. Their structures were elucidated on the basis of spectroscopic analysis, mainly NMR and MS. Compounds 1- 3 exhibited good antimalarial activity against the multidrug-resistant K1 strain of Plasmodium falciparum, while compound 4 was inactive. None of the compounds were cytotoxic against any of the tumor cell lines tested.
Pudhom
Khanitha
K
Research Centre of Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, Thailand. Khanitha.P@chula.ac.th
Sommit
Damrong
D
Suwankitti
Nattida
N
Petsom
Amorn
A
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029911:Caesalpinia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D012639:Seeds / Q000737:chemistry; D013785:Thailand
D000962:Antimalarials; D004224:Diterpenes; C524301:bonducelipin E; C524303:bonducelipin F; C524302:bonducelipin G