title: [Association of variations in MyoD family of genes with body measurement traits in goat].
abstract: Single nucleotide polymorphisms (SNPs) of hircine myf-5, myf-6 genes and 5'flanking region of the myoD gene (myoD 5') were analyzed by PCR-SSCP in Boer goat and Xuhuai white goat. Three genotypes were found at the myf-5 locus of Xuhuai white goat, denoted AA, AB and BB, while all of Boer goats were of AA genotype. Only AA and AB genotypes were found at myf-6 and myoD 5' loci. The effects of genotypes of myf-5, myf-6 and myoD 5'flanking region loci on body measurement traits were estimated. The results showed that genotypes at the myf-5 locus were significantly associated with hucklebone width and hucklebone width index in Xuhuai white goat (P<0.05). Genotypes at the myf-6 locus were significantly associated with withers heights and hucklebone width index in Boer goat (P<0.05), but no significant associations were found for any traits in Xuhuai white goat. The myoD 5' locus was not significantly associated with any traits in both types of goat.
authors.affiliation: Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou 221116, China. haijunzh1981@126.com
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Xing-Tang
authors.initials: XT
authors.lastname: Fang
authors.forename: Run-Feng
authors.initials: RF
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Bao
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Gao
authors.forename: Ru-Ying
authors.initials: RY
authors.lastname: Shao
mesh_terms: D000818:Animals; D049628:Body Size / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006041:Goats / Q000235:genetics*; D017570:MyoD Protein / Q000235:genetics*; D051787:Myogenic Regulatory Factor 5 / Q000235:genetics; D018006:Myogenic Regulatory Factors / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018807:Polymorphism, Single-Stranded Conformational
chemical_list: D017570:MyoD Protein; D051787:Myogenic Regulatory Factor 5; D018006:Myogenic Regulatory Factors; C063403:myogenic factor 6