title: Breast cancer and motor neuron disease: clinical study of seven cases.
abstract: We report seven women, aged 52-78 years, with motor neuron disease (MND) associated with breast cancer. In five, cancer preceded MND by 30 years to 24 months, while in the remaining two it occurred from 8.5 years to one month after MND onset. Three patients were considered cured of their cancer at the time of the study. Four patients have died, one from associated colonic cancer, and three from MND. As in a previous report, the clinical pattern of MND in these patients was that of predominant upper motor neuron involvement in 6/7 cases. Three had frontotemporal dementia. No anti-neuronal antibodies were found. Although there is no recognized pathophysiological link between breast cancer and UMN-predominant MND we suggest there may be comorbidity between the two diseases.
authors.affiliation: Service de Neurologie, Centre SLA, CHU de la Côte de Nacre, Caen, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Sadot
authors.forename: Laurence
authors.initials: L
authors.lastname: Carluer
authors.forename: Philippe
authors.initials: P
authors.lastname: Corcia
authors.forename: Yves
authors.initials: Y
authors.lastname: Delozier
authors.forename: Christelle
authors.initials: C
authors.lastname: Levy
authors.forename: Fausto
authors.initials: F
authors.lastname: Viader
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000150:complications*