Effect of autologous blood transfusion on the rate of biochemical recurrence after radical prostatectomy.
OBJECTIVE
To test the association between autologous blood transfusion (ABT) and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large group of contemporary patients.


METHODS
We analysed 1291 patients treated with RP; Kaplan-Meier analysis was used to graphically explore the association between ABT and BCR. Cox regression models addressed the association between ABT and BCR in univariate and multivariate analyses, after adjusting for preoperative prostate specific antigen level, pathological Gleason sum, extracapsular extension, seminal vesicle invasion and lymph node invasion.


RESULTS
Of all patients, 205 (15.4%) received perioperative ABT. The mean (median, range) follow-up was 43.2 (40.9, 0.3-145) months. BCR was recorded in 347 (26.9%) patients and the time to BCR was 25.2 (20.5, 0.3-107) months. Neither in univariate (P = 0.053) nor in multivariate (P = 0.2) Cox regression analyses was ABT a statistically significant or independent predictor of BCR.


CONCLUSIONS
Perioperative ABT does not predispose to a higher rate of BCR in patients after RP.
Gallina
Andrea
A
Department of Urology, Vita-Salute University San Raffaele, Milan, Italy.
Briganti
Alberto
A
Chun
Felix K-H
FK
Walz
Jochen
J
Hutterer
Georg C
GC
Erbersdobler
Andreas
A
Eichelberg
Christian
C
Schlomm
Thorsten
T
Ahyai
Sascha A
SA
Perrotte
Paul
P
Saad
Fred
F
Montorsi
Francesco
F
Huland
Hartwig
H
Graefen
Markus
M
Karakiewicz
Pierre I
PI
D000328:Adult; D000368:Aged; D016063:Blood Loss, Surgical; D001804:Blood Transfusion, Autologous / Q000009:adverse effects*; D004812:Epidemiologic Methods; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000209:etiology* / Q000473:pathology; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
D017430:Prostate-Specific Antigen