Arguing for the motion: yes, RAGE is a receptor for advanced glycation endproducts.
Advanced glycation endproducts (AGEs) are an heterogenous class of compounds formed by diverse stimuli, including hyperglycemia, oxidative stress, inflammation, renal failure, and innate aging. Recent evidence suggests that dietary sources of AGE may contribute to pathology. AGEs impart diverse effects in cells; evidence strongly suggests that crosslinking of proteins by AGEs may irrevocably alter basement membrane integrity and function. In addition, the ability of AGEs to bind to cells and activate signal transduction, thereby affecting broad properties in the cellular milieu, indicates that AGEs are not innocent bystanders in the diseases of AGEing. Here, we present evidence that receptor for AGE (RAGE) is a receptor for AGEs.
Ramasamy
Ravichandran
R
Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Yan
Shi Fang
SF
Schmidt
Ann Marie
AM
D000818:Animals; D002417:Cattle; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000737:chemistry; D008239:Lysine / Q000031:analogs & derivatives / Q000378:metabolism; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*; D015398:Signal Transduction
D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; C048496:N(6)-carboxymethyllysine; D008239:Lysine