title: Eremophilane-type sesquiterpenes from Senecio nemorensis.
abstract: Three new highly oxygenated eremophilane-type sesquiterpenes, 1 beta,10 beta(8,12)-diepoxy-7 beta,11 beta-dihydroxy-8 beta,12 alpha-dimethoxyeremophilane (1), 1 beta,10 beta-epoxy-7 beta-hydroxy-8 alpha-methoxyeremophil-11 alphaH-12,8 beta-olide (2), and 6 beta-isobutyryloxy-8 alpha-hydroxy-1-oxoeremophil-7(11),9-dien-12,8 beta-olide (3), together with nine known compounds (4-12) were isolated from the roots and aerial parts of Senecio nemorensis L. (Compositae). Structures of compounds 1-3 were elucidated on the basis of spectroscopic evidence including IR, HR-ESI-MS, 1D and 2D NMR techniques and were unequivocally confirmed by single-crystal X-ray diffraction experiments. The antimicrobial activity of the isolated compounds 1-3 and 8-12 was tested against Staphylococcus aureus and Candida albicans.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Fei
authors.forename: Zhan-Xin
authors.initials: ZX
authors.lastname: Zhang
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Chen
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
mesh_terms: D002176:Candida albicans / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D012674:Senecio / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D012717:Sesquiterpenes