Self-assembly of okadaic acid as a pathway to the cell.
The polyether toxin okadaic acid (OA) inhibits several protein serine/threonine phosphatases that play central roles in the regulation of many essential cellular processes. The use of scanning tunneling microscopy (STM) shows that dimerization of such toxins is crucial to understand the mechanism of toxin transport across model membranes.
Daranas
Antonio Hernández
AH
Instituto Universitario de Bio-OrgAnica Antonio GonzAlez, Astrofísico Francisco SAnchez 2, Universidad de La Laguna, 38206 La Laguna, Tenerife, Spain.
Cruz
Patricia G
PG
Creus
Alberto Hernández
AH
Norte
Manuel
M
Fernández
José J
JJ
D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D008387:Marine Toxins / Q000494:pharmacology*; D016252:Microscopy, Scanning Tunneling / Q000379:methods; D008954:Models, Biological; D015394:Molecular Structure; D019319:Okadaic Acid / Q000737:chemistry / Q000494:pharmacology*; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D008387:Marine Toxins; D019319:Okadaic Acid; D010749:Phosphoprotein Phosphatases