Comparison of trazodone, diazepame and dibenzepine influences on rat brain beta-endorphins content.
The aim of our study was to establish the extent of influence of different psychotropic drugs to brain Beta-endorphins in experimental animals. The study was performed on albino Wistar rats (weight 250 g), treated with different psychoactive drugs. RIA technique was employed for quantification of brain beta-endorphins. Brain beta-endorphins were higher in experiment group treated with trazodone (929 pg/g +/- 44,43; X+/-SD), and dibenzepine (906,63 pg/g +/- 74,06), yet with lower brain content in rats treated with diazepam (841,55 pg/g +/- 68,47), compared to brain beta-endorphins content of control group treated with saline solution (0,95% NaCl) (873,5 pg/g +/- 44,89). Significant differences were obtained comparing brain beta-endorphins of trazodone vs. diazepam treated animals, with diazepam group having lower values (p<0,02). This study showed differences in changes of rat brain beta-endorphins contents when different psychoactive drugs are used. Therefore, we consider that beta-endorphins could be used for evaluation of effects of psychoactive drugs, as a useful parameter in therapy with these psycho-pharmaceuticals.
Jadrić
Radivoj
R
Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo, Cekalusa 90, 71 000 Sarajevo, Bosnia and Herzegovina.
Hasić
Sabaheta
S
Kiseljaković
Emina
E
Winterhalter-Jadrić
Mira
M
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D005786:Gene Expression Regulation; D008956:Models, Chemical; D011619:Psychotropic Drugs / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D014196:Trazodone / Q000494:pharmacology*; D001615:beta-Endorphin / Q000378:metabolism*
D014151:Anti-Anxiety Agents; D003975:Diazepam; D003984:Dibenzazepines; D011619:Psychotropic Drugs; D017367:Selective Serotonin Reuptake Inhibitors; D014196:Trazodone; D001615:beta-Endorphin; C084605:dibenzepin