title: Hypersplenism induced by splenic vein ligation.
abstract: Warm autoimmune hemolytic anemia (AIHA) is a rare clinical entity. It is usually caused by an IgG autoantibody directed against the red blood cell membrane that causes extravascular hemolysis predominantly in the spleen. As a result, disease states or procedures that result in hypersplenism would be expected to increase red cell destruction in patients with an underlying warm AIHA. We present the case of a patient with a previously undiagnosed warm AIHA, who developed worsening hemolysis after undergoing splenic vein ligation during a pancreaticoduodenectomy to remove a neuroendocrine tumor.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Garibaldi
authors.forename: Karen E
authors.initials: KE
authors.lastname: King
authors.forename: Julie M
authors.initials: JM
authors.lastname: Jaffe
authors.forename: Alison R
authors.initials: AR
authors.lastname: Moliterno
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000150:complications*; D001803:Blood Transfusion; D004386:Duodenum / Q000601:surgery; D006461:Hemolysis; D006801:Humans; D006971:Hypersplenism / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D013162:Splenic Vein / Q000601:surgery*; D016896:Treatment Outcome