Antiphospholipid antibodies in blood and cerebrospinal fluids of patients with psychosis.
Antiphospholipid antibodies (aPL) have been reported in the cerebrospinal fluids (CSF) of neurology patients but no CSF studies with psychiatric patients exist. We tested serum from 100 hospitalized psychotic patients having hallucinations and/or delusions for aPL. Patients with positive serum aPL findings were asked to submit CSF for aPL testing. Five CSF samples had aPL specificities not found in the patient's serum suggesting the possibility of intrathecal synthesis. Specificity and isotype discordance between CSF and blood aPL in these psychiatric patients implicates a central nervous system independent autoimmune process that may have an underlying association with the pathophysiology of their diseases.
Sokol
Deborah K
DK
Indiana University School of Medicine, Department of Neurology 575 West Drive-XE 40 Indianapolis, IN 46202, USA. dksokol@iupui.edu
O'Brien
Roderick S
RS
Wagenknecht
Dawn R
DR
Rao
Thota
T
McIntyre
John A
JA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D020274:Autoimmune Diseases of the Nervous System / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D001714:Bipolar Disorder / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D001921:Brain / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D001923:Brain Chemistry / Q000276:immunology*; D005260:Female; D006212:Hallucinations / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D006801:Humans; D050356:Lipid Metabolism / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000276:immunology*; D011237:Predictive Value of Tests; D011618:Psychotic Disorders / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D012559:Schizophrenia / Q000097:blood / Q000134:cerebrospinal fluid; D012563:Schizophrenia, Paranoid / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D012680:Sensitivity and Specificity
D001323:Autoantibodies; D010743:Phospholipids