Chromosome 1p21 deletion is a novel prognostic marker in patients with multiple myeloma.
The combination of fluorescence in situ hybridization with cytoplasmic light chain detection identified chromosome 1p21 deletion in 18 (20%) of 87 patients with multiple myeloma. 1p21 deletion was associated with higher serum calcium level, 13q deletion, and t(4;14). Patients with 1p21 deletions had a significantly shorter progression-free survival (PFS) (median 10.5 vs. 22.3 months, P = 0.0002) and shorter overall survival (OS) (median 33.9 months vs. not reached, P = 0.002) than those without 1p21 deletions. On multivariate analysis, which included deletions of 13q, TP53, t(4;14) and CKS1B amplification, 1p21 deletion remained as an independent risk factor for PFS (P = 0.01) and OS (P = 0.04).
Chang
Hong
H
Department of Laboratory Hematology, University Health Network, University of Toronto, Toronto, ON, Canada. hong.chang@uhn.on.ca
Ning
Yi
Y
Qi
Xiaoying
X
Yeung
Joanna
J
Xu
Wei
W
D000328:Adult; D000368:Aged; D042846:CDC2-CDC28 Kinases; D002352:Carrier Proteins / Q000235:genetics; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D002894:Chromosomes, Human, Pair 4; D018844:Cyclin-Dependent Kinases / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D005784:Gene Amplification; D017353:Gene Deletion; D016158:Genes, p53; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000401:mortality; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D015996:Survival Rate; D014178:Translocation, Genetic
C093090:CKS1B protein, human; D002352:Carrier Proteins; D005819:Genetic Markers; D042846:CDC2-CDC28 Kinases; D018844:Cyclin-Dependent Kinases