Cardenolides from Saussurea stella with cytotoxicity toward cancer cells.
Three new cardenolides, 3-O-beta-D-fucopyranosylstrophanthidin (1), 3-O-beta-D-quinovopyranosylperiplogenin (2), and 3-O-beta-D-glucopyranosyl-(1 --> 4)-alpha- l-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4- 10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2- 10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC 50 values of <1 microM for both cell lines. This is the first report of cardenolides occurring in a species of the family Asteraceae.
Wang
Tian-Min
TM
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
Hojo
Toshinari
T
Ran
Fu-Xiang
FX
Wang
Ru-Feng
RF
Wang
Rui-Qing
RQ
Chen
Hu-Biao
HB
Cui
Jing-Rong
JR
Shang
Ming-Ying
MY
Cai
Shao-Qing
SQ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D030441:Saussurea / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D004365:Drugs, Chinese Herbal