title: Lack of correlation between embB mutation and ethambutol MIC in Mycobacterium tuberculosis clinical isolates from China.
abstract: Seventy-four Mycobacterium tuberculosis clinical isolates from China were subjected to drug susceptibility testing using ethambutol, isoniazid, rifampin, and ofloxacin. The results revealed that the presence of embB mutations did not correlate with ethambutol resistance but was associated with multiple-drug resistance, especially resistance to both ethambutol and rifampin.
authors.affiliation: Mycobacterial Reference Center, The Research Institute of Tuberculosis, 3-1-24 Matsuyama, Kiyose, Tokyo, Japan.
authors.forename: Ruiru
authors.initials: R
authors.lastname: Shi
authors.forename: Jianyuan
authors.initials: J
authors.lastname: Zhang
authors.forename: Koji
authors.initials: K
authors.lastname: Otomo
authors.forename: Guolong
authors.initials: G
authors.lastname: Zhang
authors.forename: Isamu
authors.initials: I
authors.lastname: Sugawara
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D002681:China; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004977:Ethambutol / Q000494:pharmacology*; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D015242:Ofloxacin / Q000494:pharmacology; D010430:Pentosyltransferases / Q000235:genetics; D012293:Rifampin / Q000494:pharmacology; D014376:Tuberculosis / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D004977:Ethambutol; D015242:Ofloxacin; D010430:Pentosyltransferases; C101967:arabinosyltransferase; D007538:Isoniazid; D012293:Rifampin