title: ESR, electrochemical and reactivity studies of antitrypanosomal palladium thiosemicarbazone complexes.
abstract: Cyclic voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of novel palladium complexes with bioactive thiosemicarbazones derived from 5-nitrofurane or 5-nitrofurylacroleine. Sixteen palladium complexes grouped in two series of the formula [PdCl(2)HL] or [PdL(2)] were studied. ESR spectra of the free radicals obtained by electrolytic reduction were characterized and analyzed. The ESR spectra showed two different hyperfine patterns. The stoichiometry of the complexes does not seem to affect significantly the hyperfine constants however we observed great differences between 5-nitrofurane and 5-nitrofurylacroleine derivatives. The scavenger properties of this family of compounds were lower than Trolox.
authors.affiliation: Cátedra de Química Inorgánica, DEC, Facultad de Química, UdelaR, Montevideo, Uruguay.
authors.forename: Lucía
authors.initials: L
authors.lastname: Otero
authors.forename: Christian
authors.initials: C
authors.lastname: Folch
authors.forename: Germán
authors.initials: G
authors.lastname: Barriga
authors.forename: Carolina
authors.initials: C
authors.lastname: Rigol
authors.forename: Lucia
authors.initials: L
authors.lastname: Opazo
authors.forename: Marisol
authors.initials: M
authors.lastname: Vieites
authors.forename: Dinorah
authors.initials: D
authors.lastname: Gambino
authors.forename: Hugo
authors.initials: H
authors.lastname: Cerecetto
authors.forename: Ester
authors.initials: E
authors.lastname: Norambuena
authors.forename: Claudio
authors.initials: C
authors.lastname: Olea-Azar
mesh_terms: D002839:Chromans / Q000737:chemistry; D004563:Electrochemistry; D004578:Electron Spin Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry*
chemical_list: D002839:Chromans; D013882:Thiosemicarbazones; D014344:Trypanocidal Agents; D010165:Palladium; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid