title: Impact of methadone on drug use and risky sex in China.
abstract: This study examined the impact of methadone on drug-using and risky sexual behaviors among 557 heroin injection drug users in one of the first methadone programs in China. Structured questionnaires were administered to collect data on methadone utilization, drug use, and risky sexual behaviors. Blood samples were tested for blood-borne infections. Multivariate logistic analyses revealed that, among opioid-addicted individuals, methadone participants were less likely to use or inject drugs and share needles than nonparticipants. They also were less likely to have multiple sexual partners or have unprotected sex. Those currently enrolled in methadone maintenance had lower risk of using and injecting drugs than those who were no longer receiving methadone. Data suggest positive, short-term impact on these important behaviors, but further studies are needed to examine the long-term impact of methadone treatment on disease rates.
authors.affiliation: Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. qianhz@uab.edu
authors.forename: Han-Zhu
authors.initials: HZ
authors.lastname: Qian
authors.forename: Chun
authors.initials: C
authors.lastname: Hao
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Ruan
authors.forename: Holly M
authors.initials: HM
authors.lastname: Cassell
authors.forename: Kanglin
authors.initials: K
authors.lastname: Chen
authors.forename: Guangming
authors.initials: G
authors.lastname: Qin
authors.forename: Lu
authors.initials: L
authors.lastname: Yin
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Schumacher
authors.forename: Shu
authors.initials: S
authors.lastname: Liang
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003710:Demography; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006556:Heroin Dependence / Q000453:epidemiology* / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D012309:Risk-Taking; D012725:Sexual Behavior; D015819:Substance Abuse, Intravenous / Q000453:epidemiology*; D011795:Surveys and Questionnaires
chemical_list: D009292:Narcotic Antagonists; D008691:Methadone