title: Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation.
abstract: The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF).
authors.affiliation: Centre for Molecular Drug Design, Cockcroft Building, University of Salford, Salford, UK.
authors.forename: Eun-Ang
authors.initials: EA
authors.lastname: Raiber
authors.forename: James A
authors.initials: JA
authors.lastname: Wilkinson
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Manetti
authors.forename: Maurizio
authors.initials: M
authors.lastname: Botta
authors.forename: Jon
authors.initials: J
authors.lastname: Deakin
authors.forename: John
authors.initials: J
authors.lastname: Gallagher
authors.forename: Malcolm
authors.initials: M
authors.lastname: Lyon
authors.forename: Sylvie W
authors.initials: SW
authors.lastname: Ducki
mesh_terms: D000818:Animals; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D003198:Computer Simulation; D004285:Dogs; D006493:Heparin / Q000494:pharmacology*; D006497:Heparan Sulfate / Q000737:chemistry / Q000494:pharmacology*; D017228:Hepatocyte Growth Factor / Q000378:metabolism*; D008958:Models, Molecular; D018716:Molecular Mimicry; D015394:Molecular Structure; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D019859:Proto-Oncogene Proteins c-met; D017978:Receptors, Growth Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism*
chemical_list: D006493:Heparin; D006497:Heparan Sulfate; D017228:Hepatocyte Growth Factor; D011518:Proto-Oncogene Proteins; D019859:Proto-Oncogene Proteins c-met; D017978:Receptors, Growth Factor; C491743:MET protein, human