title: Emerging roles of proteases in tumour suppression.
abstract: Proteases have long been associated with cancer progression because of their ability to degrade extracellular matrices, which facilitates invasion and metastasis. However, recent studies have shown that these enzymes target a diversity of substrates and favour all steps of tumour evolution. Unexpectedly, the post-trial studies have also revealed proteases with tumour-suppressive effects. These effects are associated with more than 30 different enzymes that belong to three distinct protease classes. What are the clinical implications of these findings?
authors.affiliation: Carlos López-Otín is at the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain. CLO@uniovi.es
authors.forename: Carlos
authors.initials: C
authors.lastname: López-Otín
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Matrisian
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D020169:Caspases / Q000378:metabolism; D002403:Cathepsins / Q000378:metabolism; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000378:metabolism; D004195:Disease Models, Animal; D018450:Disease Progression; D016503:Drug Delivery Systems / Q000379:methods; D058851:GPI-Linked Proteins; D006801:Humans; D007610:Kallikreins / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D015260:Neprilysin / Q000378:metabolism; D010447:Peptide Hydrolases / Q000145:classification / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism; D000099271:Prostasin
chemical_list: D051722:ADAM Proteins; D000970:Antineoplastic Agents; D020169:Caspases; D002403:Cathepsins; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D058851:GPI-Linked Proteins; D007610:Kallikreins; D020782:Matrix Metalloproteinases; D008565:Membrane Proteins; D015260:Neprilysin; D010447:Peptide Hydrolases; D012697:Serine Endopeptidases; D025801:Ubiquitin; D000099271:Prostasin; C120203:PRSS21 protein, human