title: An Efficient one-pot Biginelli condensation of aliphatic aldehydes catalyzed by zinc bromide under solvent-free conditions.
abstract: Zinc bromide catalyzes the three component condensation reaction of an aldehyde, urea, and beta-ketoester or beta-diketone under solvent-free conditions to afford the corresponding dihydropyrimidinones (DHPMs) with moderate to high yields in short reaction time. The present method is very effective for the Biginelli condensation of aliphatic aldehydes.
authors.affiliation: Department of Chemistry, Liaoning University of Petroleum and Chemical Technology, Fushun, Liaoning, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Di
authors.initials: D
authors.lastname: Liu
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Liu
authors.forename: Heng
authors.initials: H
authors.lastname: Jiang
authors.forename: Genxiang
authors.initials: G
authors.lastname: Luo
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001709:Biotechnology / Q000379:methods*; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents / Q000737:chemistry*; D013997:Time Factors; D014508:Urea / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D001965:Bromides; D004952:Esters; D007659:Ketones; D011744:Pyrimidinones; D012997:Solvents; D017967:Zinc Compounds; D014508:Urea; C093802:zinc bromide