title: Isolated diastolic dysfunction--diagnostic value of tissue Doppler imaging, colour M-mode and N-terminal pro B-type natriuretic peptide.
abstract: BACKGROUND
  For diagnosis of diastolic dysfunction of the left ventricle (DDF), measurement of relaxation velocity (V(R)) by tissue Doppler imaging (V(R)), flow propagation velocity of transmitral inflow (v(p)) as well as the measurement of serum levels of N-terminal pro b-type natriuretic peptide (NT-proBNP) compete with the standard echocardiographic DDF-measures because of several disadvantages of the latter.
  
  
  METHODS
  We examined the diagnostic value of method 1, 2 and NT-proBNP in 120 patients with echocardiographic-proven DDF and in 20 patients without. Patients were classified according to the DDF-stage by standard echocardiographic parameters (transmitral E/A-ratio, deceleration time, isovolumetric relaxation time) into stage I, II and III and furthermore subdivided by the presence of dyspnoea.
  
  
  RESULTS
  V(R) and v(p) were significantly lower in patients with DDF than in patients without DDF, with no difference between the various DDF stages. Symptomatic patients showed a trend to a lower V(R). NT-proBNP was elevated in patients with DDF: Symptomatic patients with a DDF at stage I and patients with a DDF at stage II and III independent of the presence of symptoms had elevated NT-proBNP levels.
  
  
  CONCLUSIONS
  All three methods tested identified patients with DDF. NT-proBNP and v(p) were able to discriminate between symptomatic and asymptomatic patients.
authors.affiliation: Martin-Luther-University, Halle-Wittenberg, Department of Medicine III, Ernst-Grube-Str. 40, 06097, Halle/Saale, Germany. stefan.hettwer@medizin.uni-halle.de
authors.forename: S
authors.initials: S
authors.lastname: Hettwer
authors.forename: B
authors.initials: B
authors.lastname: Panzner-Grote
authors.forename: R
authors.initials: R
authors.lastname: Witthaut
authors.forename: K
authors.initials: K
authors.lastname: Werdan
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001783:Blood Flow Velocity; D003971:Diastole; D015150:Echocardiography, Doppler; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012372:ROC Curve; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging*
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain