title: [IgG-kappa type multiple myeloma with cytoplasmic crystalline inclusions].
abstract: An 82-year-old male was admitted to our hospital because of anemia with Hb 6.9/dl. The serum monoclonal IgG of the kappa type was detected. Bone marrow aspiration showed the presence of 38.9% atypical plasma cells with crystalline inclusions. These crystalline inclusions were stained with acid phosphatase, and remained unstained with MPO, PAS and Congo-Red staining. Immunofluorescence studies showed the plasma cells were positive for IgG-kappa type immunoglobulin and CD138. Electron microscopy revealed varying numbers of stick-like, rod-shaped, rhomboid or rectangular crystals of a variety of lengths and sizes with a periodicity giving an appearance of longitudinal striation. The inclusions were most often surrounded by ribosomes. Some crystalline inclusions were located in the rough-surfaced endoplasmic reticulum. Their presence was probably due to an abnormality in the synthesis and/or secretion of immunoglobulin.
authors.affiliation: Department of Clinical Laboratory, Fujieda Municipal General Hospital.
authors.forename: Chiharu
authors.initials: C
authors.lastname: Kobayashi
authors.forename: Juichi
authors.initials: J
authors.lastname: Tanabe
authors.forename: Mayako
authors.initials: M
authors.lastname: Aoki
authors.forename: Rieko
authors.initials: R
authors.lastname: Suzuuki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Asai
authors.forename: Masashi
authors.initials: M
authors.lastname: Kurita
authors.forename: Takashi
authors.initials: T
authors.lastname: Murata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mohri
mesh_terms: D000369:Aged, 80 and over; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D002479:Inclusion Bodies / Q000000981:diagnostic imaging*; D008297:Male; D009101:Multiple Myeloma / Q000276:immunology* / Q000648:ultrastructure*; D014463:Ultrasonography
chemical_list: D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains