Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics.
Mitochondria and endoplasmic reticulum (ER) have different roles in living cells but they interact both physically and functionally. A key aspect of the mitochondria-ER relationship is the modulation of Ca(2+) signaling during cell activation, which thus affects a variety of physiological processes. We focus here on the molecular aspects that control the dynamics of the organelle-organelle interaction and their relationship with Ca(2+) signals, also discussing the consequences that these phenomena have, not only for cell physiology but also in the control of cell death.
Pizzo
Paola
P
Department Biomedical Sciences, University of Padua, Viale G. Colombo 3, 35121 Padua, Italy. paola.pizzo@unipd.it
Pozzan
Tullio
T
D000818:Animals; D017209:Apoptosis; D020013:Calcium Signaling; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism* / Q000648:ultrastructure; D051336:Mitochondrial Membranes / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D009336:Necrosis
D047908:Intracellular Signaling Peptides and Proteins; D024101:Mitochondrial Proteins