[C-fos protein expression in the parietal cortex and olfactory tubercle in the hypoxic rat brain].
BACKGROUND
We have attempted to identify which parts of the brain react to ischemic attack using the four-vessel occlusion model in rats.


METHODS
We have monitored the expression of c-fos protein in the parietal cortex (R3 and T3) and in the olfactory tubercle (R4 and T4), regions which are supplied with blood by different arteries. The four-vessel occlusion was performed using the Pulsinelli's method and rats were divided into two groups: total ischemia (ligation of four blood vessels or coagulation of the vertebral artheries with bilateral ligation of carotid arteries - R group) and transient ischemic attack (ligation of four blood vessels or coagulation of the vertebral arteries with bilateral repeated ligation of carotid arteries - T group of rats, the so-called preconditioned group). Each of these groups had a control group.


CONCLUSIONS
The results showed pronounced expression of c-fos neurons in T group of rats which can explain longer survival of neurons. We believe that this model can serve as a good starting point to developing new approaches to the therapy of brain ischemia.
Puskas
Laslo
L
Institut za anatomiju, Medicinski fakultet, Beograd. puskas@dr.com
Puskas
Nela
N
Babović
Sinisa S
SS
Velicki
Lazar
L
Ivanov
Dejan
D
Mijatov-Ukropina
Ljilja
L
D000818:Animals; D002534:Hypoxia, Brain / Q000378:metabolism*; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism*; D010296:Parietal Lobe / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D016760:Proto-Oncogene Proteins c-fos