title: Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe).
abstract: BACKGROUND
  Although mild cognitive impairment (MCI) represents a high-risk factor for developing dementia, little is known about the prevalence of MCI among patients of general practitioners (GPs).
  
  
  OBJECTIVE
  Estimation of age-specific prevalence for original and modified concepts of MCI and their association with sociodemographic, medical and genetic (apoE epsilon4 genotype) factors among patients of GPs.
  
  
  METHODS
  A GP practice sample of 3,327 individuals aged 75+ was assessed by structured clinical interviews.
  
  
  RESULTS
  Prevalence was 15.4% (95% CI = 14.1-16.6) for original and 25.2% (95% CI = 23.7-26.7) for modified MCI. Rates increased significantly with older age. Positive associations were found for apoE epsilon4 allele, vascular diseases and depressive symptoms.
  
  
  CONCLUSIONS
  MCI is frequent in elderly patients of GPs. GPs have a key position in secondary prevention and care of incipient cognitive deterioration up to the diagnosis of dementia.
authors.affiliation: Department of Psychiatry, University of Leipzig, Leipzig, Germany. tobias.luck@medizin.uni-leipzig.de
authors.forename: Tobias
authors.initials: T
authors.lastname: Luck
authors.forename: Steffi G
authors.initials: SG
authors.lastname: Riedel-Heller
authors.forename: Hanna
authors.initials: H
authors.lastname: Kaduszkiewicz
authors.forename: Horst
authors.initials: H
authors.lastname: Bickel
authors.forename: Frank
authors.initials: F
authors.lastname: Jessen
authors.forename: Michael
authors.initials: M
authors.lastname: Pentzek
authors.forename: Birgitt
authors.initials: B
authors.lastname: Wiese
authors.forename: Heike
authors.initials: H
authors.lastname: Koelsch
authors.forename: Hendrik
authors.initials: H
authors.lastname: van den Bussche
authors.forename: Heinz-Harald
authors.initials: HH
authors.lastname: Abholz
authors.forename: Edelgard
authors.initials: E
authors.lastname: Moesch
authors.forename: Sandra
authors.initials: S
authors.lastname: Gorfer
authors.forename: Matthias C
authors.initials: MC
authors.lastname: Angermeyer
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Siegfried
authors.initials: S
authors.lastname: Weyerer
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D053327:Apolipoprotein E4; D003072:Cognition Disorders / Q000150:complications / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology*; D015331:Cohort Studies; D003863:Depression / Q000150:complications; D005194:Family Practice / Q000706:statistics & numerical data*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D015995:Prevalence; D012720:Severity of Illness Index; D017678:Sex Distribution; D014652:Vascular Diseases / Q000150:complications
chemical_list: D053327:Apolipoprotein E4