title: Epstein-Barr virus-associated multifocal leiomyosarcomas arising in a cardiac transplant recipient: autopsy case report and review of the literature.
abstract: Epstein-Barr virus (EBV) associated smooth muscle tumors (SMTs) have been described in patients with acquired immune deficiency syndrome (AIDS) and, more recently, in association with immunosuppression after solid-organ transplantation. We present the autopsy findings of multiple leiomyosarcomas (LMSs) in a 24-year old man who died 18 months after undergoing orthotopic cardiac transplantation for idiopathic cardiomyopathy. The recognition of EBV-driven LMS developing in cardiac transplant recipients in multiple unusual sites is crucial for the management of these patients and should include complete surgical removal anti-viral therapy and modulation of immunosuppression.
authors.affiliation: Department of Pathology, Heart Failure and Transplant Service, New York Medical College at Westchester Medical Center, Valhalla, New York, USA.
authors.forename: Samina
authors.initials: S
authors.lastname: Nur
authors.forename: Warren D
authors.initials: WD
authors.lastname: Rosenblum
authors.forename: Uma Devi
authors.initials: UD
authors.lastname: Katta
authors.forename: Humayun
authors.initials: H
authors.lastname: Islam
authors.forename: Kathy
authors.initials: K
authors.lastname: Brown
authors.forename: Gita
authors.initials: G
authors.lastname: Ramaswamy
mesh_terms: D000328:Adult; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D016027:Heart Transplantation / Q000276:immunology; D004854:Herpesvirus 4, Human; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007890:Leiomyosarcoma / Q000276:immunology / Q000473:pathology / Q000821:virology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000276:immunology / Q000473:pathology / Q000821:virology*; D018235:Smooth Muscle Tumor / Q000276:immunology / Q000473:pathology / Q000821:virology