title: Effector functions of pathogenic Yersinia species.
abstract: Pathogenic species of the genus Yersinia suppress and reorient the immune system to infect lymphatic tissues, inner organs and at times also the vasculature. For this purpose yersiniae employ a type III secretion system to translocate effector proteins (Yersinia outer proteins; Yops) into immune cells. Yops often exert unique biochemical activities for modulating the activity of Rho GTP-binding proteins, focal adhesion proteins, inflammatory pathways and cell survival/apoptosis. In this review we will put emphasis on the biochemistry, cell- and infection biology of Yersinia effector Yops.
authors.affiliation: Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Diagnostikzentrum, Universitätsklinikum Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. m.aepfelbacher@uke.uni-hamburg.de
authors.forename: Martin
authors.initials: M
authors.lastname: Aepfelbacher
authors.forename: Claudia
authors.initials: C
authors.lastname: Trasak
authors.forename: Klaus
authors.initials: K
authors.lastname: Ruckdeschel
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism; D018988:Bacterial Translocation; D003546:Cysteine Endopeptidases / Q000378:metabolism; D022001:Focal Adhesions / Q000378:metabolism; D006801:Humans; D050296:Microbial Viability; D052899:Pore Forming Cytotoxic Proteins / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D018805:Sepsis / Q000201:enzymology / Q000378:metabolism* / Q000382:microbiology; D015398:Signal Transduction; D013729:Terpenes / Q000378:metabolism; D014774:Virulence; D015007:Yersinia / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity*; D015009:Yersinia Infections / Q000201:enzymology / Q000378:metabolism* / Q000382:microbiology; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C043908:LcrV protein, Yersinia; D052899:Pore Forming Cytotoxic Proteins; D013729:Terpenes; C109227:YopP protein, Yersinia; C116117:YopT protein, Yersinia; C063239:yopE protein, Yersinia; C060772:yopM protein, Yersinia; C415206:YopO protein, Yersinia enterocolitica; D017346:Protein Serine-Threonine Kinases; D017027:Protein Tyrosine Phosphatases; C067571:yopH protein, Yersinia; D003546:Cysteine Endopeptidases; D020741:rho GTP-Binding Proteins