title: Glucagonoma syndrome: survival 21 years with concurrent liver metastases.
abstract: A patient who survived for 21 years since initial discovery of glucagonoma with concurrent liver metastases is described. Psychiatric symptoms, weight loss, necrolytic migratory erythema, diarrhea, and diabetes mellitus developed gradually after diagnosis of the tumor. No specific treatment was administered. The longevity of this patient may be related to the slow tumor growth expressed histologically by ischemic necrosis of the malignant cells and in imaging by extensive tumor calcifications, a very rare finding in this type of the tumor.
authors.affiliation: Second Department of Medicine, University of Athens Medical School, Hippokration General Hospital, Athens, Greece.
authors.forename: Spyros P
authors.initials: SP
authors.lastname: Dourakis
authors.forename: Alexandra
authors.initials: A
authors.lastname: Alexopoulou
authors.forename: Kleoniki K
authors.initials: KK
authors.lastname: Georgousi
authors.forename: Johanna K
authors.initials: JK
authors.lastname: Delladetsima
authors.forename: George
authors.initials: G
authors.lastname: Tolis
authors.forename: Athanasios J
authors.initials: AJ
authors.lastname: Archimandritis
mesh_terms: D002114:Calcinosis; D005500:Follow-Up Studies; D005935:Glucagonoma / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000473:pathology*; D013997:Time Factors; D016896:Treatment Outcome