Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups.
One phenol-quaternary ammonium salt derivative with a flexible linker and three derivatives with a quinazoline moiety are present. Their binding affinities for DNA are discussed and it is clearly demonstrated that this class of phenol-quaternary ammonium salt derivatives could inhibit DNA transcription effectively.
Zhang
Lixia
L
College of Chemistry and Molecular Sciences, Wuhan University Hubei, Wuhan 430072, PR China.
Ren
Lige
L
Bai
Minghui
M
Weng
Liwei
L
Huang
Jing
J
Wu
Lin
L
Deng
Minggang
M
Zhou
Xiang
X
D001665:Binding Sites; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000187:drug effects / Q000235:genetics; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D010636:Phenols / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012492:Salts / Q000737:chemistry; D013696:Temperature; D014158:Transcription, Genetic / Q000187:drug effects
D003432:Cross-Linking Reagents; D010636:Phenols; D000644:Quaternary Ammonium Compounds; D011799:Quinazolines; D012492:Salts; D004247:DNA