title: Acylated flavone glycosides from the roots of Saussurea lappa and their antifungal activity.
abstract: The isolation of four novel acylated flavonoid glycosides from the roots of Saussurea lappa and their identification using a combination of 1D and 2D NMR and mass spectrometry is described. The in vitro antifungal and antibacterial activities of the isolated compounds and their mixture were tested on nine fungal and four bacterial strains, using the microdilution method. The compounds and mixture showed moderate to high antifungal activity against most of the fungi tested, compared to a miconazole standard, while only one compound and the mixture showed antibacterial activity against all strains tested.
authors.affiliation: School of Studies in Chemistry, Vikram University, Ujjain 456010, M.P. India. ksrao7709@rediffmail.com
authors.forename: Kolisetty Sambasiva
authors.initials: KS
authors.lastname: Rao
authors.forename: Goriparthi Venu
authors.initials: GV
authors.lastname: Babu
authors.forename: Yemireddy Venkata
authors.initials: YV
authors.lastname: Ramnareddy
mesh_terms: D000215:Acylation; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002247:Carbon Isotopes; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification*; D005658:Fungi / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry*; D011522:Protons; D030441:Saussurea / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000935:Antifungal Agents; D002247:Carbon Isotopes; D047309:Flavones; D006027:Glycosides; D011522:Protons