title: Bronchioloalveolar carcinoma not related to jaagsiekte sheep retrovirus in a goat.
abstract: A spontaneous lung tumor in a 5-year-old goat of the Murciano-Granadina breed is described in this paper. Clinical signs of cachexia and tachypnoea were evident, and a considerable amount of white mucous foamy fluid was discharged from the nostrils when the animal's head was lowered. A lung tumor with the characteristics of bronchioloalveolar carcinoma was detected during histopathologic examination. The tumor cells were positive for surfactant proteins C and B, confirming that alveolar type II cells were the origin of the neoplasia. Tumor samples were tested by polymerase chain reaction, immunoblotting, and immunohistochemistry for the presence of Jaagsiekte sheep retrovirus (JSRV) and enzootic nasal tumor virus (ENTV), another retrovirus very closely related to JSRV, but all tests were negative. Therefore, this is the first reported case of spontaneous bronchioloalveolar carcinoma not related to JSRV or ENTV infection in a goat.
authors.affiliation: Departamento de Patología Animal, Universidad de Zaragoza, C/Miguel Servet 177, 50013 Zaragoza, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Ortín
authors.forename: A A
authors.initials: AA
authors.lastname: Benito
authors.forename: D
authors.initials: D
authors.lastname: Lacasta
authors.forename: L M
authors.initials: LM
authors.lastname: Ferrer
authors.forename: M
authors.initials: M
authors.lastname: De Las Heras
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D015511:Goat Diseases / Q000473:pathology*; D006041:Goats; D022141:Jaagsiekte sheep retrovirus; D008175:Lung Neoplasms / Q000473:pathology / Q000662:veterinary*