title: Serum cytokine levels in active uveitis and remission.
abstract: Serum levels of interleukin(IL)-8, IL-6, and (TNF)-alpha were measured in 25 patients during active uveitis and uveitis in remission and compared to age-matched controls. Levels of IL-8 and IL-6 were significantly elevated in patients with active disease and were decreased during remission. IL-8 levels were highest in patients with anterior uveitis, with greatest difference between active disease and remission. No consistent pattern was observed for TNF-alpha. In conclusion, serum cytokine levels are elevated in active noninfectious uveitis. The rise in IL-8 may suggest innate immune mechanisms in the acute disease, while IL-6 participates in modulation of inflammation in the chronic disease.
authors.affiliation: Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel. mkramer@netvision.net.il
authors.forename: M
authors.initials: M
authors.lastname: Kramer
authors.forename: Y
authors.initials: Y
authors.lastname: Monselise
authors.forename: I
authors.initials: I
authors.lastname: Bahar
authors.forename: Y
authors.initials: Y
authors.lastname: Cohen
authors.forename: D
authors.initials: D
authors.lastname: Weinberger
authors.forename: N
authors.initials: N
authors.lastname: Goldenberg-Cohen
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D015864:Panuveitis / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014606:Uveitis, Anterior / Q000097:blood*; D015866:Uveitis, Posterior / Q000097:blood*
chemical_list: C508606:CXCL8 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha