Nonalcoholic fatty liver disease: pathogenesis, identification, progression, and management.
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver diseases in the absence of significant alcohol consumption, and its incidence is paralleling the increasing numbers of overweight and obese individuals worldwide. This review discusses the pathogenesis of NAFLD, including the roles potentially played by specific adipokines, such as TNF-alpha, leptin, and adiponectin. Clinical features, diagnosis, and potential methods of management are also addressed to assist practitioners with the management of this growing population of patients.
Yan
Eric
E
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. eyan@mednet.ucla.edu
Durazo
Francisco
F
Tong
Myron
M
Hong
Kurt
K
D018450:Disease Progression; D005234:Fatty Liver / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D018384:Oxidative Stress; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D015431:Weight Loss
D000960:Hypolipidemic Agents