Prothrombotic risk factors in children with hemiplegic cerebral palsy.
BACKGROUND
The purpose of the present paper was to investigate the prevalence of prothrombotic risk factors associated with hemiplegic cerebral palsy (CP).


METHODS
Twenty-three hemiplegic CP patients were tested for inherited and acquired prothrombotic risk factors, except methylene tetrahydrofolate reductase (MTFR) polymorphism.


RESULTS
A total of 56.5% of patients had at least one coagulation abnormality and 13% of them had two. Four patients (8.7%) had infection and congenital heart disease, who also had additional coagulopathy risk factors. Obstetric problems were detected in 56.5%. Coagulopathy risk factors were factor V Leiden mutation (21.7%), protein C deficiency (21.7%), elevated lipoprotein-a (13%), G20210A mutation of prothrombin (8.7%), and protein S deficiency (4.3%).


CONCLUSIONS
Children with hemiplegic CP need to be evaluated for coagulopathic abnormalities.
Senbil
Nesrin
N
Department of Child Neurology, Dr Sami Ulus Children's Hospital, Ankara, Turkey. senbilon@yahoo.com
Yüksel
Deniz
D
Yilmaz
Deniz
D
Gürer
Y K Yavuz
YK
D002547:Cerebral Palsy / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013927:Thrombosis / Q000150:complications*