title: Pemphigus foliaceus-like drug reaction in a 3-month-old crossbreed dog treated for juvenile cellulitis.
abstract: Two weeks after administration of routine vaccinations, a 3-month-old, male crossbreed dog developed cutaneous lesions that were clinically and histopathologically consistent with a diagnosis of juvenile cellulitis. The patient was treated with systemic antibacterial, antibacterial ophthalmic ointment and nonsteroidal anti-inflammatory drugs. Within 1 week, new skin lesions that were clinically, histopathologically and immunohistochemically consistent with pemphigus foliaceus developed. The latter completely resolved following drug withdrawal, suggesting a pemphigus foliaceus-like drug reaction. However, the initial lesions persisted and required glucocorticoid therapy to effect resolution. To the authors' knowledge, this is the first reported case of a puppy developing juvenile cellulitis followed by a pemphigus foliaceus-like reaction shortly thereafter, in response to drug therapy.
authors.affiliation: Clinic of Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria. chorvath@staffmail.ed.ac.uk
authors.forename: Christa
authors.initials: C
authors.lastname: Horvath
authors.forename: Ariane
authors.initials: A
authors.lastname: Neuber
authors.forename: Barbara
authors.initials: B
authors.lastname: Litschauer
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002481:Cellulitis / Q000188:drug therapy / Q000662:veterinary; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D008297:Male; D010392:Pemphigus / Q000139:chemically induced / Q000175:diagnosis / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents