title: Low hepatic cytochrome P450 3A activity is a risk for corticosteroid-induced osteonecrosis.
authors.forename: A N
authors.initials: AN
authors.lastname: Nafziger
authors.forename: J S
authors.initials: JS
authors.lastname: Bertino
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D015415:Biomarkers / Q000378:metabolism; D001711:Biotransformation; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000201:enzymology; D006801:Humans; D006900:Hydroxylation; D008099:Liver / Q000201:enzymology*; D008874:Midazolam / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D013379:Substrate Specificity
chemical_list: D000305:Adrenal Cortex Hormones; D015415:Biomarkers; D003577:Cytochrome P-450 Enzyme System; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; D008874:Midazolam