[On the role of brain serotonin system in the pathway from gene to behaviour].
This paper concentrates on involvement of protein elements in the brain neurotransmitter serotonin system (key enzymes in serotonin metabolism and 5-HT(1A) receptors) in the genetic control of behaviour. The data were obtained using Norway rats selected for more that 50 generations for lack of aggressive response and for aggressive behaviour towards humans (fear-induced aggression), inbred mouse strains, and MAO A knockout mice. The review provides converging line of evidence that: 1) brain serotonin contributes to critical mechanism underlying genetically defined individual differences in aggressiveness, and 2) genes encoding pivotal enzymes in serotonin metabolism (tryptophan hydroxylase, MAO A) and 5-HT(1A) receptors belong to a group of genes that modulate aggressive behaviour.
Popova
N K
NK
D000374:Aggression; D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000201:enzymology* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008995:Monoamine Oxidase / Q000172:deficiency / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D044263:Receptors, Serotonin, 5-HT1 / Q000235:genetics / Q000378:metabolism*; D012701:Serotonin / Q000235:genetics / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D044263:Receptors, Serotonin, 5-HT1; D012701:Serotonin; D008995:Monoamine Oxidase