Phase resetting in one-dimensional model of the sinoatrial node.
In this paper, we use a one-dimensional model of the rabbit sinoatrial node (SAN), and we investigate the response of the model to hyperpolarizing and depolarizing stimulus. Depending on the stimulus timing, either a delay or an advance in the occurrence of next action potential is produced. This resetting behavior of the model is quantified in terms of phase transition curves (PTCs) for short electrical current pulses of varying amplitude which span the whole period. The main focus of this paper is to compare the dynamic properties of the spatially extended system and the single cell model. The detailed analysis of the results provides new insights in the understanding of the transition from the theoretical single cell models to the spatially extended systems.
Tsalikakis
D G
DG
Unit of Medical Technology and Intelligent Information Systems, Department of Computer Science, University of Ioannina, GR 45110 Ioannina, Greece.
Fotiadis
D I
DI
Michalis
L K
LK
Kremmydas
G P
GP
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D003198:Computer Simulation; D008955:Models, Cardiovascular; D009991:Oscillometry / Q000379:methods*; D011817:Rabbits; D012849:Sinoatrial Node / Q000502:physiology*