Responses of ultra-weak chemiluminescence and secretory IgA in saliva to the induction of angry and depressive moods.
Oxidative damage to tissues and cells contributes to disease processes. We used ultra-weak chemiluminescence (uwCL) as an indicator of oxidative activity to examine the effects of psychological challenges on oxidative responses. We also examined the association of underlying psychological characteristics with oxidative and immune responses. Eighteen healthy men and women with a mean age of 24.1 were recruited. Anger and depressive symptoms were evaluated using the State-Trait Anger Expression Inventory and the Center for Epidemiological Studies Depression Scale, respectively. Following a baseline period, participants were required to complete two separate speech tasks where they were asked to recall life events that made them feel angry (AT) or depressed (DT). The tasks were separated by a 30-min recovery period and the order was randomized between participants using a counterbalanced design. Saliva was sampled and assayed for uwCL and secretory immunoglobulin A (sIgA). The level of uwCL was significantly increased in response to both tasks (p<.05), whereas sIgA concentrations decreased significantly in response to DT (p<.05). At 30 min after each task, uwCL values were positively related to anger-in (p<.005), anger expression (p<.05) and trait anger (p<.05) post-AT, and sIgA concentrations were positively related to anger-out (p<.05) post-AT and -DT, after controlling for covariates. The present study suggests that induction of angry and depressive moods can increase oxidative activity and transiently weaken immunity indicated by salivary sIgA concentrations. In addition, anger personality traits may modify these responses.
Tsuboi
Hirohito
H
Department of Developmental and Regenerative Medicine, Institute of Genomics and Regenerative Biology, Mie University Graduate School of Medicine, Tsu, Japan.
Hamer
Mark
M
Tanaka
Gohichi
G
Takagi
Kuniaki
K
Kinae
Naohide
N
Steptoe
Andrew
A
D000328:Adult; D000786:Anger / Q000502:physiology*; D003863:Depression / Q000276:immunology* / Q000523:psychology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D008163:Luminescent Measurements; D008297:Male; D015213:Neuroimmunomodulation / Q000502:physiology*; D009483:Neuropsychological Tests; D018384:Oxidative Stress / Q000276:immunology; D012463:Saliva / Q000276:immunology / Q000378:metabolism; D013315:Stress, Psychological / Q000276:immunology*
D007070:Immunoglobulin A