title: A novel class of potent NF-kappaB signaling inhibitors.
abstract: A novel class of NF-kappaB pathway signaling inhibitors was discovered by virtual screening, medicinal chemistry, and QSAR analysis. An initial set of compounds inhibited NF-kappaB signaling in a whole cell reporter gene assay in the micro-molar range. Activity was improved step by step by medicinal chemistry to yield nano-molar signaling inhibitors.
authors.affiliation: 4SC AG, Am Klopferspitz 19a, 82152 Martinsried, Germany. leban@4sc.com
authors.forename: Johann
authors.initials: J
authors.lastname: Leban
authors.forename: Marcel
authors.initials: M
authors.lastname: Baierl
authors.forename: Jan
authors.initials: J
authors.lastname: Mies
authors.forename: Viola
authors.initials: V
authors.lastname: Trentinaglia
authors.forename: Sandra
authors.initials: S
authors.lastname: Rath
authors.forename: Kerstin
authors.initials: K
authors.lastname: Kronthaler
authors.forename: Kristina
authors.initials: K
authors.lastname: Wolf
authors.forename: Astrid
authors.initials: A
authors.lastname: Gotschlich
authors.forename: Markus H J
authors.initials: MH
authors.lastname: Seifert
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D021281:Quantitative Structure-Activity Relationship; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D016328:NF-kappa B