The IL23 axis plays a key role in the pathogenesis of IBD.
Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.
McGovern
Dermot
D
Imperial College, London, Hammersmith Hospital Campus Du Cane Road, London W12 0HS, UK. dermotmcgovern@doctors.net.uk
Powrie
Fiona
F
D000818:Animals; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D018664:Interleukin-12 / Q000235:genetics; D053759:Interleukin-23 / Q000235:genetics* / Q000276:immunology; D051379:Mice; D018123:Receptors, Interleukin / Q000235:genetics / Q000276:immunology
C515500:IL23R protein, human; D053759:Interleukin-23; D018123:Receptors, Interleukin; D018664:Interleukin-12