From simple Ugi adducts to indanes and delta-amidomalonates: new manganese(III)-induced radical cascades.
A complete change of the traditional Ugi adducts framework has been obtained using new radical cascades as Ugi post-condensation reactions. Indanes and delta-amidomalonates were thus obtained in a one-pot procedure from aromatic aldehydes under a sequence involving Ugi addition followed by treatment of the adducts with Mn(III) and malonate or beta-ketoester. The radical step probably involves an intramolecular aryl transfer followed by an oxidative cleavage and final cyclization to indanes.
Kaim
Laurent El
LE
Laboratoire Chimie et procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris Cedex 15, France. laurent.elkaim@ensta.fr
Grimaud
Laurence
L
Vieu
Emilie
E