title: Hydrogel nanocomposites as remote-controlled biomaterials.
abstract: Nanocomposite hydrogels are a new class of intelligent materials which have recently attracted interest as biomaterials. In this study, magnetic nanocomposites of temperature-sensitive hydrogels have been developed and demonstrated to be responsive to alternating magnetic fields. Nanocomposites were synthesized by incorporation of superparamagnetic Fe(3)O(4) particles in negative temperature-sensitive poly(N-isopropylacrylamide) hydrogels. The systems were characterized for temperature-responsive swelling, remote heating on application of an alternating magnetic field and remote-controlled drug delivery applications. The rise in temperature in external alternating magnetic field depends on the Fe(3)O(4) particle loading of the system. Preliminary studies on remote-controlled drug release showed reduced release in the presence of an alternating magnetic field.
authors.affiliation: Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.
authors.forename: Nitin S
authors.initials: NS
authors.lastname: Satarkar
authors.forename: J
authors.initials: J
authors.lastname: Zach Hilt
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry; D006358:Hot Temperature; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D008280:Magnetics; D053761:Nanocomposites / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors
chemical_list: D000178:Acrylamides; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D052203:Ferrosoferric Oxide