title: Propionibacterium endocarditis: a case series from the International Collaboration on Endocarditis Merged Database and Prospective Cohort Study.
abstract: Propionibacterium species are occasionally associated with serious systemic infections such as infective endocarditis. In this study, we examined the clinical features, complications and outcome of 15 patients with Propionibacterium endocarditis using the International Collaboration on Endocarditis Merged Database (ICE-MD) and Prospective Cohort Study (ICE-PCS), and compared the results to 28 cases previously reported in the literature. In the ICE database, 11 of 15 patients were male with a mean age of 52 y. Prosthetic valve endocarditis occurred in 13 of 15 cases and 3 patients had a history of congenital heart disease. Clinical findings included valvular vegetations (9 patients), cardiac abscesses (3 patients), congestive heart failure (2 patients), and central nervous system emboli (2 patients). Most patients were treated with beta-lactam antibiotics alone or in combination for 4 to 6 weeks. 10 of the 15 patients underwent valve replacement surgery and 2 patients died. Similar findings were noted on review of the literature. The results of this paper suggest that risk factors for Propionibacterium endocarditis include male gender, presence of prosthetic valves and congenital heart disease. The clinical course is characterized by complications such as valvular dehiscence, cardiac abscesses and congestive heart failure. Treatment may require a combination of medical and surgical therapy.
authors.affiliation: Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Cube 7545, Durham, NC 27710 USA. lalan002@mc.duke.edu
authors.forename: Tahaniyat
authors.initials: T
authors.lastname: Lalani
authors.forename: Anna K
authors.initials: AK
authors.lastname: Person
authors.forename: Susan S
authors.initials: SS
authors.lastname: Hedayati
authors.forename: Laura
authors.initials: L
authors.lastname: Moore
authors.forename: David R
authors.initials: DR
authors.lastname: Murdoch
authors.forename: Bruno
authors.initials: B
authors.lastname: Hoen
authors.forename: Gail
authors.initials: G
authors.lastname: Peterson
authors.forename: Hasan
authors.initials: H
authors.lastname: Shahbaz
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
authors.forename: Jose M
authors.initials: JM
authors.lastname: Miro
authors.forename: Lars
authors.initials: L
authors.lastname: Olaison
authors.forename: Ulrika
authors.initials: U
authors.lastname: Snygg-Martino
authors.forename: Fredy
authors.initials: F
authors.lastname: Suter
authors.forename: Dennis
authors.initials: D
authors.lastname: Spelman
authors.forename: Susannah
authors.initials: S
authors.lastname: Eykyn
authors.forename: Jacob
authors.initials: J
authors.lastname: Strahilevitz
authors.forename: Jan T
authors.initials: JT
authors.lastname: Van der Meer
authors.forename: Dominique
authors.initials: D
authors.lastname: Verhagen
authors.forename: Khaula
authors.initials: K
authors.lastname: Baloch
authors.forename: Elias
authors.initials: E
authors.lastname: Abrutyn
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Cabell
mesh_terms: D000193:Actinomycetales Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D016208:Databases, Factual; D004697:Endocarditis, Bacterial / Q000150:complications / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D006331:Heart Diseases / Q000150:complications / Q000151:congenital / Q000453:epidemiology / Q000382:microbiology; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006801:Humans; D007391:International Cooperation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011424:Propionibacterium / Q000145:classification / Q000302:isolation & purification; D011446:Prospective Studies; D016459:Prosthesis-Related Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D012307:Risk Factors; D015996:Survival Rate