Adipose stress-sensing kinases: linking obesity to malfunction.
Obesity has been proposed to inflict a variety of stresses on adipose tissue, including inflammatory, metabolic, oxidative and endoplasmic reticulum stress. Through the activation of 'stress-sensing pathways', metabolic and endocrine alterations are produced, which probably contribute to the co-morbidities associated with obesity. Here, we review the evidence supporting the development of various obesity-related stresses and the activation of several stress-sensing pathways, specifically in adipocytes and/or adipose tissue, which manifest metabolic and endocrine dysfunction frequently in obesity. As the central role of adipose tissue in regulating whole-body metabolism is elucidated, understanding adipose tissue stress-sensing pathways might provide potential new therapeutic targets to attenuate obesity-related morbidity.
Rudich
Assaf
A
Department of Clinical Biochemistry Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84103 Israel.
Kanety
Hannah
H
Bashan
Nava
N
D000273:Adipose Tissue / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D006801:Humans; D006984:Hypertrophy; D007249:Inflammation / Q000201:enzymology / Q000209:etiology; D008954:Models, Biological; D009765:Obesity / Q000150:complications / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D010770:Phosphotransferases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013312:Stress, Physiological / Q000201:enzymology*
D010770:Phosphotransferases