Resting energy expenditure, adiponectin and changes in body composition of young children (EarlyBird 34).
OBJECTIVE. Serum adiponectin levels are inversely related to adiposity and resting energy expenditure (REE) in adults yet may protect against excess weight gain. Little is known of these associations in children, in whom obesity is rising. The aim of this study was therefore to investigate the relationships between REE, adiponectin and weight gain in young children. METHODS. Adiponectin by ELISA, REE by indirect calorimetry, fat-free mass (FFM) and fat mass (FM) by DEXA were measured at 6.9 years, and repeated one year later in 151 healthy children, aged 7.9±0.3 years. RESULTS. There were no significant correlations between REE and adiponectin at 6.9 years or at 7.9 years (boys r=-0.02, p=0.88 and r=0.05, p=0.69, respectively; girls r=-0.11, p=0.35 and r=0.05, p=0.70, respectively). There was no link between REE at 6.9 years and subsequent weight gain or adverse change in body composition (all r<0.20, all p>0.08). Similarly, there were no correlations between adiponectin and weight change, but there was a significant inverse association between adiponectin at 6.9 years and FFM gain in boys (r=-0.27, p=0.02). CONCLUSIONS. The relationship between adiponectin and REE has yet to appear in young children. REE is not a significant predictor of future weight gain or adverse change in body composition and, although the period of follow-up was limited, adiponectin seems unlikely to confound such a relationship in healthy young children.
Hosking
Joanne
J
Department of Endocrinology & Metabolism, Peninsula Medical School, Plymouth campus, UK.
Metcalf
Brad S
BS
Jeffery
Alison N
AN
Gardner
Daphne
D
Voss
Linda D
LD
Wilkin
Terence J
TJ
D015502:Absorptiometry, Photon; D052242:Adiponectin / Q000097:blood; D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D002153:Calorimetry, Indirect; D002648:Child; D004734:Energy Metabolism; D004739:England; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D012737:Sex Factors; D015430:Weight Gain
C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers