Leptin-to-adiponectin ratio as independent predictor of insulin sensitivity during growth in overweight Hispanic youth.
Because leptin and adiponectin are counter-regulated in vivo and exert opposing effects on glucose metabolism, fat oxidation and insulin sensitivity, the ratio of leptin-to-adiponectin has been investigated as a potential atherogenic index, suggesting that the index is a better biomarker for atherosclerotic risk in obese Type 2 diabetic patients than either leptin or adiponectin alone. However, no information is available regarding the leptin-to-adiponectin ratio during adolescence in Hispanic adolescents. Therefore, the present study was designed to investigate the leptin-to-adiponectin ratio during growth and to establish whether the leptin-to-adiponectin ratio is a better predictor for insulin sensitivity compared to leptin and adiponectin alone in a regression model. From the age of 8 to 14, the leptin-to-adiponectin ratio increased from 2.0+/-0.8 to 5.8+/-2.2 in girls, with no significant change noted in boys (gender x age interaction p=0.007). In a multiple regression analysis, including both adiponectin and leptin as independent variables, leptin and adiponectin explained 5% of the variation in insulin sensitivity independent of gender, age, Tanner stage, total fat mass and lean body mass (p for R2-change <0.001). The leptin-to-adiponectin ratio also explained 5% of the variation in insulin sensitivity, after controlling for the same covariates (p for R2-change <0.001). These data indicate that the leptin-to-adiponectin ratio is not a better predictor of insulin sensitivity during growth than the additive effects of leptin and adiponectin levels.
Koebnick
C
C
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9008, USA.
Shaibi
G Q
GQ
Kelly
L A
LA
Roberts
C K
CK
Lane
C J
CJ
Toledo-Corral
C
C
Davis
J N
JN
Byrd-Williams
C
C
Weigensberg
M J
MJ
Goran
M I
MI
D052242:Adiponectin / Q000032:analysis*; D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D003940:Diagnostic Techniques, Endocrine; D005260:Female; D005951:Glucose Tolerance Test; D006128:Growth / Q000502:physiology*; D006630:Hispanic or Latino; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000032:analysis*; D008297:Male; D050177:Overweight; D011379:Prognosis; D012727:Sex Characteristics
D052242:Adiponectin; D020738:Leptin