title: Synthesis and in-vitro activity of novel 1beta-methylcarbapenems having spiro[2,4]heptane moieties.
abstract: The synthesis of a new series of 1beta-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in-vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. Most compounds were shown to be more active than the compared meropenem and imipenem against Escherichia coli. One particular compound, IIIb, having hydroxy a moiety showed the most potent antibacterial activity.
authors.affiliation: Department of Chemistry, Hanyang University, Seoul, Korea.
authors.forename: Hyeong Beom
authors.initials: HB
authors.lastname: Park
authors.forename: Nam Hyun
authors.initials: NH
authors.lastname: Jo
authors.forename: Joon Hee
authors.initials: JH
authors.lastname: Hong
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Chei
authors.forename: Jung-Hyuck
authors.initials: JH
authors.lastname: Cho
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Yoo
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Oh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015780:Carbapenems / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: C476323:1 beta-methylcarbapenem; D000900:Anti-Bacterial Agents; D015780:Carbapenems; D013141:Spiro Compounds