title: New insights into the enantioselectivity in the hydrogenation of prochiral ketones.
abstract: The high enantioselectivity in the hydrogenation of acetophenone catalysed by trans-Ru(H)2(S,S-dpen)(S-xylbinap) is explained in terms of the existence of a stable intermediate formed when the reactant enters the catalyst pocket fixing the molecular orientation.
authors.affiliation: Johnson Matthey Technology Centre, Blount's Court, Sonning Common, UK RG4 9NH. frencsa@matthey.com
authors.forename: Samuel A
authors.initials: SA
authors.lastname: French
authors.forename: Devis
authors.initials: D
authors.lastname: Di Tommaso
authors.forename: Antonio
authors.initials: A
authors.lastname: Zanotti-Gerosa
authors.forename: Fred
authors.initials: F
authors.lastname: Hancock
authors.forename: C Richard A
authors.initials: CR
authors.lastname: Catlow
mesh_terms: D006859:Hydrogen / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D006859:Hydrogen