[Early diagnosis of invasive fungal infections caused by Aspergillus and other emerging mycelial fungi].
The usefulness of surrogate markers in the diagnosis of invasive fungal infections caused by Aspergillus and other emerging mycelial fungi is based on the ability of surrogate markers to detect the infection caused by different species of mycelial fungi. Conventional microbiological methods for diagnosis of fungal disease are slow and insensitive. Antigen based assays or measurement of (1-3)-beta-D-glucan in blood have been developed and validated in clinical laboratories. We review these diagnostic contemporary tools, their clinical application and impact.
del Palacio
Amalia
A
Unidad de Micología, Servicio de Microbiología, Hospital Doce de Octubre, Madrid, Spain. apalacioh.hdoc@salud.madrid.org
Alhambra
Almudena
A
Cuétara
María Soledad
MS
Pontón
José
J
D000908:Antibodies, Fungal / Q000097:blood; D000946:Antigens, Fungal / Q000097:blood; D001228:Aspergillosis / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers; D002986:Clinical Trials as Topic; D021821:Communicable Diseases, Emerging / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D004271:DNA, Fungal / Q000097:blood; D042241:Early Diagnosis; D016469:Fungemia / Q000175:diagnosis / Q000453:epidemiology; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D007158:Immunologic Techniques; D008351:Mannans / Q000097:blood; D011237:Predictive Value of Tests; D011509:Proteoglycans; D012307:Risk Factors; D020096:Zygomycosis / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D047071:beta-Glucans / Q000097:blood
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D015415:Biomarkers; D004271:DNA, Fungal; D008351:Mannans; D011509:Proteoglycans; D047071:beta-Glucans; C012990:galactomannan; C010770:polysaccharide-K; D005690:Galactose