title: CSF orexin-A/hypocretin-1 concentrations in patients with intracerebral hemorrhage (ICH).
abstract: Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of both the feeding behavior neuroendocrine functions and sleep-wakefulness cycle. Recent studies have suggested that the orexin system may also be involved in neuronal damage in the clinical setting and animal experiments. The aim of this study was to examine the role of the hypothalamic orexin-A/hypocretin-1 system in patients with intracerebral hemorrhage (ICH). The CSF orexin-A/hypocretin-1 levels were measured in 11 ICH patients. CSF orexin-A/hypocretin-1 levels were low in ICH patients during the 13 days following the ICH event. The mean CSF orexin-A/hypocretin-1 levels were 61.1+/-22.3 (S.D.) pg/ml (range 27.5-106.9 pg/ml). The decreasing in the CSF orexin-A/hypocretin-1 levels was not related to the severity of ICH. The CSF orexin-A/hypocretin-1 levels were lower in the thalamic hemorrhage patients than those in other patients (48.5+/-23.3 pg/ml vs. 65.2+/-21.2 pg/ml; p=0.03.) These data indicate that orexin-A/hypocretin-1 may therefore play an important role in the various physiological responses including sleep, feeding, and the overall metabolism in ICH patients.
authors.affiliation: Showa University, Department of Emergency and Critical Care Medicine, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan. kdop@med.showa-u.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Dohi
authors.forename: Beth
authors.initials: B
authors.lastname: Ripley
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fujiki
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Ohtaki
authors.forename: Takefumi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Goto
authors.forename: Tomoya
authors.initials: T
authors.lastname: Nakamachi
authors.forename: Seiji
authors.initials: S
authors.lastname: Shioda
authors.forename: Tohru
authors.initials: T
authors.lastname: Aruga
authors.forename: Seiji
authors.initials: S
authors.lastname: Nishino
mesh_terms: D002543:Cerebral Hemorrhage / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins
chemical_list: C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins