title: [C-fos protein expression in the parietal cortex and olfactory tubercle in the hypoxic rat brain].
abstract: BACKGROUND
  We have attempted to identify which parts of the brain react to ischemic attack using the four-vessel occlusion model in rats.
  
  
  METHODS
  We have monitored the expression of c-fos protein in the parietal cortex (R3 and T3) and in the olfactory tubercle (R4 and T4), regions which are supplied with blood by different arteries. The four-vessel occlusion was performed using the Pulsinelli's method and rats were divided into two groups: total ischemia (ligation of four blood vessels or coagulation of the vertebral artheries with bilateral ligation of carotid arteries - R group) and transient ischemic attack (ligation of four blood vessels or coagulation of the vertebral arteries with bilateral repeated ligation of carotid arteries - T group of rats, the so-called preconditioned group). Each of these groups had a control group.
  
  
  CONCLUSIONS
  The results showed pronounced expression of c-fos neurons in T group of rats which can explain longer survival of neurons. We believe that this model can serve as a good starting point to developing new approaches to the therapy of brain ischemia.
authors.affiliation: Institut za anatomiju, Medicinski fakultet, Beograd. puskas@dr.com
authors.forename: Laslo
authors.initials: L
authors.lastname: Puskas
authors.forename: Nela
authors.initials: N
authors.lastname: Puskas
authors.forename: Sinisa S
authors.initials: SS
authors.lastname: Babović
authors.forename: Lazar
authors.initials: L
authors.lastname: Velicki
authors.forename: Dejan
authors.initials: D
authors.lastname: Ivanov
authors.forename: Ljilja
authors.initials: L
authors.lastname: Mijatov-Ukropina
mesh_terms: D000818:Animals; D002534:Hypoxia, Brain / Q000378:metabolism*; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism*; D010296:Parietal Lobe / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016760:Proto-Oncogene Proteins c-fos