title: Prothrombotic risk factors in children with hemiplegic cerebral palsy.
abstract: BACKGROUND
  The purpose of the present paper was to investigate the prevalence of prothrombotic risk factors associated with hemiplegic cerebral palsy (CP).
  
  
  METHODS
  Twenty-three hemiplegic CP patients were tested for inherited and acquired prothrombotic risk factors, except methylene tetrahydrofolate reductase (MTFR) polymorphism.
  
  
  RESULTS
  A total of 56.5% of patients had at least one coagulation abnormality and 13% of them had two. Four patients (8.7%) had infection and congenital heart disease, who also had additional coagulopathy risk factors. Obstetric problems were detected in 56.5%. Coagulopathy risk factors were factor V Leiden mutation (21.7%), protein C deficiency (21.7%), elevated lipoprotein-a (13%), G20210A mutation of prothrombin (8.7%), and protein S deficiency (4.3%).
  
  
  CONCLUSIONS
  Children with hemiplegic CP need to be evaluated for coagulopathic abnormalities.
authors.affiliation: Department of Child Neurology, Dr Sami Ulus Children's Hospital, Ankara, Turkey. senbilon@yahoo.com
authors.forename: Nesrin
authors.initials: N
authors.lastname: Senbil
authors.forename: Deniz
authors.initials: D
authors.lastname: Yüksel
authors.forename: Deniz
authors.initials: D
authors.lastname: Yilmaz
authors.forename: Y K Yavuz
authors.initials: YK
authors.lastname: Gürer
mesh_terms: D002547:Cerebral Palsy / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013927:Thrombosis / Q000150:complications*