Microstimulators and intramuscular hook electrodes for the stimulation of respiratory muscles.
OBJECTIVE
We determined the feasibility of stimulating the major muscles of respiration with different types of electrodes. Intramuscular hook electrodes, model microstimulators (M-Micro) developed in our laboratory, and commercial radiofrequency microstimulators (RFM) (Alfred Mann Foundation, Valencia, CA), were employed in this investigation.


METHODS
In 8 anesthetized dogs, M-Micro were placed bilaterally on the diaphragm and in the abdominal muscles, and hook electrodes were placed in the 3rd and 5th intercostal regions adjacent to the intercostal nerves known to support inspiration. In 3 of the 8 animals, RFMs (Alfred Mann Foundation) in addition to the M-Micros were sutured to each hemidiaphragm at the same optimal site for phrenic nerve stimulation. During a hyperventilation-induced apnea, 2-second stimulations were applied to the diaphragm and with various combinations of diaphragm plus supporting muscles, both thoracic and abdominal.


RESULTS
Diaphragm stimulation alone provided tidal volumes adequate for basal alveolar ventilation. However, implantation of the RFM required greater contact with the muscle. Stimulating other respiratory muscles along with the diaphragm further increased tidal volumes. The hook electrodes, M-Micro, and RFM performed equally well.


CONCLUSIONS
In the acute dog model, M-Micro and hook electrodes can provide an implant system for the maintenance of ventilation. Support of the intercostal and abdominal muscles has the potential to reduce the contraction requirements of the diaphragm with decreased likelihood of diaphragm fatigue and hypoventilation. Whether the electrodes under investigation could provide an implant system for long-term ventilation needs to be determined.
Walter
James S
JS
Research Service, Hines Veterans Administration Hospital, Hines, Illinois 60141, USA. james.walter@med.va.gov
Dunn
Robert B
RB
Wurster
Robert D
RD
Laghi
Franco
F
D000818:Animals; D003964:Diaphragm / Q000502:physiology / Q000528:radiation effects; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000295:instrumentation* / Q000379:methods*; D004567:Electrodes, Implanted; D007366:Intercostal Muscles / Q000502:physiology / Q000528:radiation effects; D010791:Phrenic Nerve / Q000502:physiology; D012121:Respiration, Artificial; D012132:Respiratory Muscles / Q000502:physiology / Q000528:radiation effects*; D013990:Tidal Volume