title: Dietary diphenyl diselenide reduces the STZ-induced toxicity.
abstract: Oxidative stress is implicated in the pathogenesis of diabetes mellitus. Selenium supplementation has some benefits in experimental models of diabetes mellitus. This study evaluated whether dietary diphenyl diselenide, a simple synthetic organoselenium compound with antioxidant properties, reduces the streptozotocin (STZ)-induced toxicity. STZ-induced diabetic rats were fed with either standard and diphenyl diselenide (10 ppm) supplemented diets. In experimental trials, dietary diphenyl diselenide significantly decreased mortality rate (p<0.05) induced by STZ treatment. No correlation between this effect and glycemic levels were found. Diphenyl diselenide intake also promoted an increase in vitamin C, -SH levels (liver, kidney and blood) and in catalase (liver and kidney) activity, which were decreased in STZ-treated rats. In enzyme assays, diphenyl diselenide supplementation caused a significant improvement in platelets NTPDase and 5'-nucleotidase activities in STZ-induced diabetic rats when compared to the control and diabetic groups (p<0.05). Nevertheless, this supplementation did not modify the inhibition induced by STZ in delta-ALA-D activity. Our findings suggest that diphenyl diselenide compound showed beneficial effects against the development of diabetes by exhibiting antioxidant properties.
authors.affiliation: Universidade Federal de Santa Maria - UNIPAMPA, Centro de Ciências da Saúde, Rua Domingos de Almeida, 3525, São Miguel, 97500-009 Uruguaiana, RS, Brazil. nvbarbosa@yahoo.com.br
authors.forename: N B V
authors.initials: NB
authors.lastname: Barbosa
authors.forename: J B T
authors.initials: JB
authors.lastname: Rocha
authors.forename: J C M
authors.initials: JC
authors.lastname: Soares
authors.forename: D C
authors.initials: DC
authors.lastname: Wondracek
authors.forename: J F
authors.initials: JF
authors.lastname: Gonçalves
authors.forename: M R C
authors.initials: MR
authors.lastname: Schetinger
authors.forename: C W
authors.initials: CW
authors.lastname: Nogueira
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001555:Benzene Derivatives / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000517:prevention & control*; D004032:Diet; D008297:Male; D009929:Organ Size / Q000187:drug effects; D016566:Organoselenium Compounds / Q000494:pharmacology*; D000623:Porphobilinogen Synthase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000032:analysis; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001555:Benzene Derivatives; D001786:Blood Glucose; D016566:Organoselenium Compounds; D013438:Sulfhydryl Compounds; C061132:diphenyldiselenide; D002374:Catalase; D015720:5'-Nucleotidase; D000623:Porphobilinogen Synthase; D000254:Sodium-Potassium-Exchanging ATPase; D012643:Selenium