title: Synthesis, structure and cytotoxicity of triphenylphosphinegold(I) sulfanylpropenoates.
abstract: The reaction of triphenylphosphinegold(I) chloride in ethanol in a 1:1 molar ratio with the 3-(aryl)-2-sulfanylpropenoic acids H(2)xspa [x: p=3-phenyl-, Clp=3-(2-chlorophenyl)-, -o-mp=3-(2-methoxyphenyl)-, -p-mp=3-(4-methoxyphenyl)-, -o-hp=3-(2-hydroxyphenyl)-, -p-hp=3-(4-hydroxyphenyl)-, diBr-o-hp=3-(3,5-dibromo-2-hydroxyphenyl)-, f=3-(2-furyl)-, t=3-(2-thienyl)-, -o-py=3-(2-pyridyl)-; spa=2-sulfanylpropenoato] gave compounds of the type [Au(PPh(3))(Hxspa)], which were isolated and characterized as solids by elemental analysis, IR spectroscopy and FAB mass spectrometry and in solution by (1)H, (13)C and (31)P NMR spectroscopy. The structures of the complexes [Au(PPh(3))(HClpspa)], [Au(PPh(3))(H-o-mpspa)] and [Au(PPh(3))(H-p-mpspa)].2/3C(3)H(6)O were determined by X-ray diffractometry. Hydrogen bonding was found along with Au-S and Au-P bonds in all cases and weak pi-pi stacking was found in the H-p-mpspa derivative. The in vitro antitumour activities against the HeLa-229, A2780 and A2780cis cell lines were determined for all complexes.
authors.affiliation: Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Barreiro
authors.forename: José S
authors.initials: JS
authors.lastname: Casas
authors.forename: María D
authors.initials: MD
authors.lastname: Couce
authors.forename: Agustín
authors.initials: A
authors.lastname: Sánchez
authors.forename: Angeles
authors.initials: A
authors.lastname: Sánchez-Gonzalez
authors.forename: José
authors.initials: J
authors.lastname: Sordo
authors.forename: José M
authors.initials: JM
authors.lastname: Varela
authors.forename: Ezequiel M
authors.initials: EM
authors.lastname: Vázquez López
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D050607:Organogold Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000179:Acrylates; D000970:Antineoplastic Agents; D050607:Organogold Compounds; D010720:Phosphines; C016798:triphenylphosphine gold chloride