title: Blood flow analysis of the head and lower limbs by the laser Doppler blood flowmeter during LDL apheresis.
abstract: The presence of peripheral arterial disease substantially increases the risk for both morbidity and mortality among end-stage renal disease patients. Low-density lipoprotein (LDL) apheresis has been also applied for the treatment of peripheral arterial disease to reduce LDL levels, resulting in the improvement of the blood flow to the ischemic limbs. In this study, we investigated the continuous changes of the tissue blood flows in the lower limbs and head during LDL-apheresis treatment by a non-invasive method (the non-invasive continuous monitoring method (NICOMM) system). In this study, the tissue blood flow in both the head and lower limbs showed a significantly enhancement from before to after treatment. The tissue blood flow in the lower limbs showed a significantly larger improvement than that in the head. The short-term effects of LDL apheresis were confirmed by using the NICOMM system; thus, this system will be useful for the determination of the appropriate schedule of LDL apheresis for long-term effectiveness.
authors.affiliation: Department of Nephrology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan. itaruebi@yahoo.co.jp
authors.forename: Itaru
authors.initials: I
authors.lastname: Ebihara
authors.forename: Takashi
authors.initials: T
authors.lastname: Sato
authors.forename: Kouichi
authors.initials: K
authors.lastname: Hirayama
authors.forename: Masanori
authors.initials: M
authors.lastname: Seki
authors.forename: Terukazu
authors.initials: T
authors.lastname: Enami
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Kawahara
authors.forename: Jun
authors.initials: J
authors.lastname: Niwayama
authors.forename: Takaaki
authors.initials: T
authors.lastname: Miyahara
authors.forename: Masamichi
authors.initials: M
authors.lastname: Shibata
authors.forename: Nobuki
authors.initials: N
authors.lastname: Maeda
authors.forename: Takesi
authors.initials: T
authors.lastname: Kurosawa
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yamagata
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sanaka
mesh_terms: D000368:Aged; D005260:Female; D006257:Head / Q000098:blood supply*; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008077:Lipoproteins, LDL / Q000302:isolation & purification*; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000628:therapy*; D010956:Plasmapheresis; D012039:Regional Blood Flow; D006435:Renal Dialysis
chemical_list: D008077:Lipoproteins, LDL