Bioengineering of a composite nerve graft for peripheral nerve reconstruction.
Engineering of nerve graft substitutes is challenging because of the complex cell and tissue interactions leading to successful nerve regeneration. Moreover cells in contrast to the extracellular nerve matrix are rejected by the immune system. We have developed ofa non-immunogenic nerve scaffold that can be seeded with autogenous Schwann cells prior to implantation in patients suffering extensive peripheral nerve lesions.
Dumont
Charles E
CE
Zieglerspital, Bern.
D000818:Animals; D006497:Heparan Sulfate / Q000494:pharmacology; D023421:Models, Animal; D009416:Nerve Regeneration / Q000502:physiology; D010525:Peripheral Nerves / Q000601:surgery*; D051381:Rats; D019651:Plastic Surgery Procedures; D012583:Schwann Cells / Q000637:transplantation*; D023822:Tissue Engineering / Q000379:methods*
D006497:Heparan Sulfate