title: Association between asthma, asthma symptoms and C-reactive protein in US adults: data from the National Health and Nutrition Examination Survey, 1999-2002.
abstract: OBJECTIVE
  CRP is elevated in several inflammatory diseases; however, little is known about its association with asthma.
  
  
  METHODS
  The study evaluated the associations between CRP, asthma and asthma symptoms using data on 8020 adults >or=20 years of age from the latest US National Health and Nutrition Examination Survey.
  
  
  RESULTS
  The prevalence estimates of current asthma, wheezing and nocturnal cough were 3.6% (95% CI: 2.9-4.4), 14.7% (95% CI: 13.7-15.8) and 4.6% (95% CI: 3.8-5.3), respectively. Geometric mean of CRP was 0.20 mg/dL (95% CI: 0.19-0.21). The majority of female (69.5%) respondents were in the fourth (highest) quartile of CRP. Mean CRP levels were significantly higher in non-Hispanic blacks as compared with non-Hispanic whites. The adjusted odds of current asthma and past asthma (as compared with no asthma) were 1.60 (95% CI: 1.02-2.53) and 1.43 (95% CI: 1.07-1.91), respectively, greater in the fourth quartile of CRP. The adjusted odds of presence of both wheezing and nocturnal cough were 2.18 and 3.40 in the third and fourth quartile of CRP, respectively.
  
  
  CONCLUSIONS
  This study shows that adults with asthma and asthma symptoms have higher levels of CRP. The potential use of CRP as a clinically useful marker for asthma severity and control should be further explored.
authors.affiliation: Texas Tech University Health Sciences Center, Department of Family and Community Medicine, Lubbock, Texas 79416, USA. ahmed.arif@ttuhsc.edu
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Arif
authors.forename: George L
authors.initials: GL
authors.lastname: Delclos
authors.forename: Jane
authors.initials: J
authors.lastname: Colmer-Hamood
mesh_terms: D000328:Adult; D001249:Asthma / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D016017:Odds Ratio; D015995:Prevalence; D012135:Respiratory Sounds / Q000503:physiopathology; D014481:United States
chemical_list: D002097:C-Reactive Protein