title: Possible prognostic significance of p53 and Ki 67 in inverted sinonasal papilloma.
abstract: The aim of this study is to test the possible prognostic significance of p53 and Ki67 expression in inverted papilloma of the lateral nasal wall and adjacent sinuses regarding their malignant potential and recurrence. 49 biopsies of the lateral nasal wall and adjacent sinuses obtained from 41 patients from three hospitals were investigated. Immunohistochemically demonstrated p53 and Ki67 expression was measured and statistically evaluated. p53 immunoreactivity was demonstrated in most of papillomas with carcinomas but only in two benign papillomas, while Ki67 demonstrated stronger immunoreactivity in carcinomas and surrounding epithelium. Immunohistochemical staining of inverted sinonasal papillomas for p53 and Ki67 can give useful information concerning the existence of synchronous carcinoma and, in case of high Ki67, a hint toward possible recurrence.
authors.affiliation: Department of Otorhinolaryngology, University Hospital Center, Zagreb, Croatia.
authors.forename: Miljenko
authors.initials: M
authors.lastname: Bura
authors.forename: Sven
authors.initials: S
authors.lastname: Seiwerth
authors.forename: Ivan
authors.initials: I
authors.lastname: Vladika
authors.forename: Darko
authors.initials: D
authors.lastname: Perović
authors.forename: Paul
authors.initials: P
authors.lastname: Nagy
authors.forename: Marijana
authors.initials: M
authors.lastname: Corić
authors.forename: Lana
authors.initials: L
authors.lastname: Bijelić
authors.forename: Zdenko
authors.initials: Z
authors.lastname: Krajina
authors.forename: Marica Zizić
authors.initials: MZ
authors.lastname: Mitrecić
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D018308:Papilloma, Inverted / Q000378:metabolism* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53