The prevalence of colorectal neoplasia in patients with end-stage renal disease: a case-control study.
OBJECTIVE
The scarcity of organs for transplantation has led to aggressive pretransplant evaluations. Many younger kidney transplant patients with end-stage renal disease, who would be ordinarily at average risk for colorectal cancer, undergo screening colonoscopy as part of this evaluation. The purpose of this study was to determine the prevalence of colorectal neoplasia in patients with end-stage renal disease who are potential transplant candidates.


METHODS
We performed a retrospective chart review analysis on 57 kidney transplant candidates who underwent pretransplant screening colonoscopy between August 1999 and December 2004. The control group was comprised of 60 age- and gender-matched subjects without end-stage renal disease who underwent routine screening colonoscopy.


RESULTS
The prevalence of polyps in end-stage renal disease patients was 37 vs 22% in the control group (p=0.07, not significant). None of the risk factors studied were found to predict the presence of polyps in the study group.


CONCLUSIONS
These results suggest that screening guidelines for colorectal cancer for the general population should be adequate for potential kidney transplant recipients.
Lee
Sharon
S
Division of Colorectal and Pelvic Floor Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Wasserberg
Nir
N
Petrone
Patrizio
P
Rosca
Jason
J
Selby
Rick
R
Ortega
Adrian
A
Kaufman
Howard S
HS
D016022:Case-Control Studies; D003111:Colonic Polyps / Q000453:epidemiology* / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D011230:Precancerous Conditions / Q000453:epidemiology* / Q000473:pathology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors