Calcium signalling and cell-fate choice in B cells.
Alterations in the cytosolic concentration of calcium ions (Ca2+) transmit information that is crucial for the development and function of B cells. Cytosolic Ca2+ concentration is determined by a balance of active transport and gradient-driven Ca2+ fluxes, both of which are subject to the influence of multiple receptors and environmental sensing pathways. Recent advances in genomics have allowed for the compilation of an increasingly comprehensive list of Ca2+ transporters and channels expressed by B cells. The increasing understanding of the function and regulation of these proteins has begun to shift the frontier of Ca2+ physiology in B cells from molecular analysis to determining how diverse inputs to cytosolic Ca2+ concentration are integrated in specific immunological contexts.
Scharenberg
Andrew M
AM
Department of Pediatrics, University of Washington School of Medicine and Children's Hospital and Regional Medical Center, Suite 300, 307 Westlake Avenue, Seattle, Washington 98109, USA. andrewms@u.washington.edu
Humphries
Lisa A
LA
Rawlings
David J
DJ
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D051966:Phospholipase C gamma / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000502:physiology
D011947:Receptors, Antigen, B-Cell; D015544:Inositol 1,4,5-Trisphosphate; D051966:Phospholipase C gamma; D002118:Calcium