Synthesis and evaluation of novel N-H and N-substituted indole-2- and 3-carboxamide derivatives as antioxidants agents.
We have previously reported on the synthesis of novel indole derivatives where some compounds showed significant antioxidant activity. Here, we report the synthesis of novel N-H and N-substituted indole-2- and 3-carboxamide derivatives and investigated their antioxidant role in order to identify structural characteristics responsible for activity. Although all compounds showed a strong inhibitory (95-100%) effect on superoxide anion (SOD) only compounds 4, 5 and 6 showed simliar potency for the inhibition of lipid peroxidation (81-94%) which revealed that compounds 4, 5 and 6 possessed highly potent antioxidant properties. Substitution in the 1-position of the indole ring caused the significant differences between the activity results regarding lipid peroxidation inhibition.
Olgen
Süreyya
S
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara, Tandogan/Ankara, 06100, Turkey. olgen@pharmacy.ankara.edu.tr
Kiliç
Zuhal
Z
Ada
Ahmet O
AO
Coban
Tulay
T
D000577:Amides / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006859:Hydrogen / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008297:Male; D009584:Nitrogen / Q000737:chemistry; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013481:Superoxides / Q000378:metabolism
D000577:Amides; D000975:Antioxidants; D007211:Indoles; D013481:Superoxides; D002244:Carbon; D006859:Hydrogen; D009584:Nitrogen