title: Novel approaches to therapy of hypereosinophilic syndromes.
abstract: There has been recent progress in the understanding of the pathogenesis of the hypereosinophilic syndromes (HES). This led to the distinction of subgroups, in which the underlying cause has been identified. Consequently, new treatment options became available, such as imatinib and mepolizumab, which proved to be promising. This article summarizes these new pharmacologic approaches to the therapy of HES.
authors.affiliation: Department of Pharmacology, University of Bern, Friedbuehlstrasse 49, CH-3010 Bern, Switzerland. hus@pki.unibe.ch
authors.forename: Hans-Uwe
authors.initials: HU
authors.lastname: Simon
authors.forename: Jan
authors.initials: J
authors.lastname: Cools
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001549:Benzamides; D016026:Bone Marrow Transplantation; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000628:therapy*; D000068877:Imatinib Mesylate; D015514:Oncogene Proteins, Fusion / Q000378:metabolism*; D010879:Piperazines / Q000627:therapeutic use*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011743:Pyrimidines / Q000627:therapeutic use*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism*; D039221:mRNA Cleavage and Polyadenylation Factors / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D001549:Benzamides; D015514:Oncogene Proteins, Fusion; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D039221:mRNA Cleavage and Polyadenylation Factors; D000068877:Imatinib Mesylate; C479819:FIP1L1-PDGFRA fusion protein, human; D011505:Protein-Tyrosine Kinases; D020796:Receptor, Platelet-Derived Growth Factor alpha