title: Antibacterial activity of remifentanil and mixtures of remifentanil and propofol.
abstract: OBJECTIVE
  To investigate the antibacterial activity of glycine, which is contained in remifentanil, when combined with propofol.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Departments of anesthesiology and microbiology of a university hospital.
  
  
  METHODS
  Growth of the microorganisms Staphylococcus epidermidis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans in propofol 1%; saline dilutions of remifentanil at one-, 10-, and 100-microg/mL concentrations; and 1:1 mixtures of propofol with remifentanil solutions was determined.
  
  
  RESULTS
  Remifentanil inhibits bacterial growth in a concentration-dependent manner. The antibacterial effects were more pronounced with Staphylococcus aureus and Pseudomonas aeruginosa at cultures obtained at the fifth hour. The inhibition of bacterial growth was less influenced with Escherichia coli and Candida albicans.
  
  
  CONCLUSIONS
  Propofol and remifentanil mixtures decreased bacterial growth, and combinations may reduce the infectious complications from accidentally contaminated propofol.
authors.affiliation: Department of Microbiology, Kirikkale University Faculty of Medicine, Kirikkale 71100, Turkey. teomanapan@yahoo.com
authors.forename: Teoman Zafer
authors.initials: TZ
authors.lastname: Apan
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Apan
authors.forename: Saziye
authors.initials: S
authors.lastname: Sahin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cakirca
mesh_terms: D019162:Anesthetics, Combined / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005998:Glycine / Q000737:chemistry / Q000494:pharmacology; D018684:Glycine Agents / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D015742:Propofol / Q000737:chemistry / Q000494:pharmacology*; D011446:Prospective Studies; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D000077208:Remifentanil; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development
chemical_list: D019162:Anesthetics, Combined; D018684:Glycine Agents; D010880:Piperidines; D000077208:Remifentanil; D005998:Glycine; D015742:Propofol