Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and endometriosis in a Japanese population.
OBJECTIVE
We investigated a possible association between endometriosis and polymorphisms in the genes encoding epidermal growth factor (EGF) receptor (EGFR) and EGF in a Japanese population.


METHODS
We compared the distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms by polymerase chain reaction-restriction fragment length polymorphism analysis in 146 affected women and 181 controls.


RESULTS
No significant differences in the frequency and genotype distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms were found between endometriosis patients with all disease stages and controls. Stratification by disease stage had no effect on the results.


CONCLUSIONS
The Egfr+2073 A/T and Egf+61 G/A polymorphisms are not associated with an increased risk of endometriosis in a Japanese population.
Inagaki
Mieko
M
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
Yoshida
Shigeki
S
Kennedy
Stephen
S
Takemura
Naoya
N
Deguchi
Masashi
M
Ohara
Noriyuki
N
Maruo
Takeshi
T
D000328:Adult; D054458:Amplified Fragment Length Polymorphism Analysis; D044466:Asian People / Q000235:genetics; D016009:Chi-Square Distribution; D004715:Endometriosis / Q000235:genetics*; D004815:Epidermal Growth Factor / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D007564:Japan; D016017:Odds Ratio; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics; D012720:Severity of Illness Index
D004815:Epidermal Growth Factor; D066246:ErbB Receptors