Effects of chronic stress on nicotine-induced locomotor activity and corticosterone release in adult and adolescent rats.
We examined nicotine-induced locomotion and increase in corticosterone plasma levels in adolescent and adult animals exposed to chronic restraint stress. Adolescent [postnatal day (P) 28-37] and adult (P60-67) rats were restrained for 2 hours once daily for 7 days. Three days after the last exposure to stress, the animals were challenged with saline or nicotine (0.4 mg/kg subcutaneously). Nicotine-induced locomotion was recorded in an activity cage. Trunk blood samples were collected in a subset of adolescent and adult rats and plasma corticosterone levels were determined by radioimmunoassay. Exposure to stress did not affect the nicotine-induced locomotor- or corticosterone-activating effects in both ages.
Cruz
Fábio C
FC
Laboratory of Pharmacology, School of Pharmaceutical Sciences, UNESP-Sao Paulo State University, Brazil.
DeLucia
Roberto
R
Planeta
Cleopatra S
CS
D000367:Age Factors; D000818:Animals; D001143:Arousal / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical / Q000523:psychology; D013315:Stress, Psychological / Q000097:blood / Q000150:complications*
D009538:Nicotine; D003345:Corticosterone