title: N-Methyl substituted 2',4'- BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization.
abstract: Oligonucleotides modified with a novel BNA analogue, 2', 4'-BNA(NC)[N-Me], were synthesized, and in comparison to 2',4'-BNA (LNA), have similarly high RNA affinity, better RNA selectivity and much higher resistance to nuclease degradation, suggesting that the novel BNA analogue may be particularly useful for antisense approaches.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. imanishi@phs.osaka-u.ac.jp.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Miyashita
authors.forename: S M Abdur
authors.initials: SM
authors.lastname: Rahman
authors.forename: Sayori
authors.initials: S
authors.lastname: Seki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
mesh_terms: D001483:Base Sequence; D004720:Endonucleases / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis* / Q000187:drug effects / Q000494:pharmacology; D012313:RNA / Q000737:chemistry*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D016376:Oligonucleotides, Antisense; D012313:RNA; D004720:Endonucleases