title: Topical application of mitomycin C in the treatment of esophageal and tracheobronchial stricture: a report of 2 cases.
abstract: We present 2 cases of successful treatment of recurrent anastomotic strictures using a topical application of mitomycin C. In the first case, a 4-year-old boy had a cervical cyst excised, which appeared to be an ectopic gastric mucosa. He consequently presented severe stenosis at the origin of the cervical esophagus that needed repeated balloon dilatations. The second case is about a 12-year-old girl who presented a traumatic complete rupture of the right mainstem bronchus managed by primary repair, with subsequent anastomotic stricture. Both patients were successfully managed with topical application of mitomycin C (1 mg/mL), and needed no more dilatations.
authors.affiliation: Department of Pediatric Surgery, Hotel Dieu de France Hospital, Beirut, Lebanon. jmpaul@dm.net.lb
authors.forename: Paul
authors.initials: P
authors.lastname: Daher
authors.forename: Edward
authors.initials: E
authors.lastname: Riachy
authors.forename: Beyrouthy
authors.initials: B
authors.lastname: Georges
authors.forename: Dabar
authors.initials: D
authors.lastname: Georges
authors.forename: Moukarzel
authors.initials: M
authors.lastname: Adib
mesh_terms: D000287:Administration, Topical; D000714:Anastomosis, Surgical / Q000009:adverse effects; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003251:Constriction, Pathologic / Q000188:drug therapy / Q000209:etiology; D004940:Esophageal Stenosis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D011183:Postoperative Complications; D012008:Recurrence; D014135:Tracheal Stenosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D016685:Mitomycin