title: Microwave-promoted facile and efficient preparation of N-(alkoxycarbonylmethyl) nucleobases--building blocks for peptide nucleic acids.
abstract: A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation.
authors.affiliation: College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, PR China. quguir@163.com
authors.forename: Guirong
authors.initials: G
authors.lastname: Qu
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Haiming
authors.initials: H
authors.lastname: Guo
authors.forename: Mingwei
authors.initials: M
authors.lastname: Geng
authors.forename: Ran
authors.initials: R
authors.lastname: Xia
mesh_terms: D000478:Alkylation; D003596:Cytosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D004126:Dimethylformamide; D008872:Microwaves; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry; D013941:Thymine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013997:Time Factors; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D020135:Peptide Nucleic Acids; D011687:Purines; D014498:Uracil; D004126:Dimethylformamide; D003596:Cytosine; D013941:Thymine