title: Alloimmune neonatal neutropenia due to anti-HNA-2a alloimmunization with severe and prolonged neutropenia but mild clinical course: two case reports.
abstract: Alloimmunization to granulocyte-specific antigens can occur during pregnancy. Maternal IgG can cross the placenta and result in neonatal neutropenia. The clinical course of alloimmune neonatal neutropenia is usually self-limiting with only mild infection. However, in severe cases complicated with bacterial sepsis it is a potentially life-threatening disorder. The effect of intravenous (IV) immunoglobulin, prophylactic antibiotic therapy, and recombinant human granulocyte-colony stimulating factor is variable and may prove useful in some cases. Two cases of alloimmune neonatal neutropenia due to anti HNA-2a alloimmunization in two siblings are reported. The first neonate was administered IV gammaglobulins to increase the blood neutrophil count, at a standard dosage (0.4 g/kg body weight) for 5 days without response. The second neonate did not receive specific therapy for blood neutrophil count increase. Neutropenia persisted for 2 and 6 months, respectively. The choice and efficacy of specific therapy for neutrophil count increase in the management of alloimmune neonatal neutropenia have not yet been fully defined and require additional evaluation in the majority of cases.
authors.affiliation: Department of Immunohematology, Croatian Institute of Transfusion Medicine, Zagreb, Croatia. maja.tomicic@hztm.htnet.hr
authors.forename: Maja
authors.initials: M
authors.lastname: Tomicic
authors.forename: Mirta
authors.initials: M
authors.lastname: Starcevic
authors.forename: Vanja
authors.initials: V
authors.lastname: Zach
authors.forename: Zeljka
authors.initials: Z
authors.lastname: Hundric-Haspl
mesh_terms: D000328:Adult; D019072:Antibiotic Prophylaxis; D000906:Antibodies / Q000276:immunology*; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007231:Infant, Newborn; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D009503:Neutropenia / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D010920:Placenta / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology*; D012720:Severity of Illness Index; D035781:Siblings
chemical_list: D000906:Antibodies; C407242:CD177 protein, human; D058851:GPI-Linked Proteins; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D007519:Isoantigens; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface