Usefulness of BNP-administration in cardiac surgery: animal model.
OBJECTIVE
The pharmacologic properties of Brain natriuretic peptide make it a favourable substance to use after cardiac operations. The goal of this study was to evaluate the effect of BNP following cardio-pulmonary bypass (CPB).


METHODS
Nineteen pigs were operated on using CPB. One group received BNP and the control group received placebo. A 30-minute ischemic episode was simulated. Following declamping, BNP was administered by an IV bolus, followed by an infusion for 60 minutes. Hemodynamic and clinical chemistry parameters were documented, as well as the amount of catecholamines.


RESULTS
The Cardiac output and Cardiac Index in the BNP group were significantly higher 60 minutes after ending CPB. Seven of ten animals in the control group needed catecholamines at the end of the experiment, whereas none of the animals in the BNP group did at this juncture. Creatine kinase and Lactate were significantly lower.


CONCLUSIONS
BNP is a well-tolerated agent that could present a new treatment option for heart failure following cardiac surgery. Hemodynamics are greatly improved with almost no need for pharmacological support.
Bail
Dorothee H L
DH
Department of Thoracic, Cardiac and Vascular Surgery, University of Tuebingen, Germany. dorothee.bail@med.uni-tuebingen.de
Brüllmann
Benjamin
B
Geim
Anita I
AI
Ziemer
Gerhard
G
D000818:Animals; D002315:Cardiopulmonary Bypass; D002395:Catecholamines; D003402:Creatine Kinase; D005260:Female; D006333:Heart Failure / Q000517:prevention & control*; D006439:Hemodynamics; D019344:Lactic Acid; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications / Q000503:physiopathology*; D045283:Natriuretic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D020097:Natriuretic Peptide, Brain / Q000008:administration & dosage* / Q000627:therapeutic use; D011184:Postoperative Period; D013552:Swine; D013997:Time Factors
D002395:Catecholamines; D045283:Natriuretic Agents; D020097:Natriuretic Peptide, Brain; D019344:Lactic Acid; D003402:Creatine Kinase