Investigation of functional gene polymorphisms: IL-1B, IL-6 and TNFA in benign migratory glossitis in Brazilian individuals.
BACKGROUND
Benign migratory glossitis (BMG) is a very common immunological oral disease of unknown aetiology.


METHODS
Fifty-three consecutive subjects affected by BMG and 53 age- and sex-matched control subjects were genotyped for IL-1B, IL-6 and TNFA polymorphisms. Binary logistic regression models were fitted and values of P < 0.05 were considered significant.


RESULTS
A significant difference in the distribution of IL-1B genotypes was observed in the group with BMG in univariate analyses (P = 0.01). The multivariate analyses showed that the CT genotype of the IL1-B gene was significantly associated with a high risk to develop BMG (P = 0.02, OR 2.76). The combined presence of IL-1beta high and intermediate producers genotypes was also associated with BMG in multivariate analyses (P = 0.01, OR 3.05). IL-6 and TNFA polymorphisms were not associated with BMG in the univariate and multivariate analyses.


CONCLUSIONS
Our findings demonstrate that the polymorphism +3954 IL-1B is associated with an increased risk of BMG development and suggest a genetic basis for disease development.
Guimarães
André Luiz Sena
AL
Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil.
Correia-Silva
Jeane de Fátima
Jde F
Diniz
Marina Gonçalves
MG
Xavier
Guilherme Machado
GM
Horta
Martinho Campolina Rebello
MC
Gomez
Ricardo Santiago
RS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001938:Brazil; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D005929:Glossitis, Benign Migratory / Q000235:genetics*; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha