Association between the serum anion gap and blood pressure among patients at Harvard Vanguard Medical Associates.
Animal and human data suggest a link between endogenous acid production with elevations in blood pressure and the development of hypertension; increases in endogenous organic acid production can lead to a higher anion gap. We studied the cross-sectional association between the serum anion gap and blood pressure among 1057 non-diabetic patients who were not taking antihypertensive drugs, and who received their care at a multisite, multispecialty group practice in eastern Massachusetts. Using linear regression controlling for age, sex, race, BMI, estimated GFR and presence of impaired fasting glucose, every 1 mEq l(-1) higher serum anion gap was associated with a 0.27 mm Hg (P=0.08) higher systolic, 0.20 mm Hg (P=0.05) higher diastolic and 0.22 mm Hg (P=0.04) higher mean arterial pressure; these results suggest that endogenous acid production may raise the risk of hypertension.
Forman
J P
JP
Rifas-Shiman
S L
SL
Taylor
E N
EN
Lane
K
K
Gillman
M W
MW
D000136:Acid-Base Equilibrium / Q000502:physiology*; D000143:Acids / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006123:Group Practice; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged
D000143:Acids