title: Mastocytosis and allergy.
abstract: OBJECTIVE
  To illustrate features of allergy in mastocytosis.
  
  
  RESULTS
  The rates of atopy in patients with mastocytosis have generally been found to be similar to those of the normal population, although the incidence of anaphylaxis is much higher in mastocytosis. Introduction of objective pathologic criteria by the WHO for the diagnosis of mastocytosis has greatly facilitated the workup of patients with suspected mastocytosis, and has led to identification of mast cell disease in a subset of patients with anaphylaxis. There is increasing evidence that an activating c-kit mutation (D816V) exists in a subset of patients with recurrent mast cell activation symptoms who have normal-appearing bone marrow biopsies in routine evaluations without skin lesions. The genetic deficiency of alpha tryptase has not been found to influence serum tryptase levels in patients with mastocytosis.
  
  
  CONCLUSIONS
  Pathologic mast cell activation is a key finding in both allergic diseases and mastocytosis, albeit caused by entirely different mechanisms. Mastocytosis should be suspected in patients with recurrent anaphylaxis, who present with syncopal or near-syncopal episodes without associated hives or angioedema.
authors.affiliation: Division of Allergy and Immunology, Department of Internal Medicine, University of Michigan, School of Medicine, Ann Arbor, Michigan 48109, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Greenhawt
authors.forename: Cem
authors.initials: C
authors.lastname: Akin
mesh_terms: D000707:Anaphylaxis / Q000276:immunology* / Q000378:metabolism; D001180:Arthropod Venoms / Q000276:immunology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008415:Mastocytosis / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D053802:Tryptases / Q000097:blood
chemical_list: D001180:Arthropod Venoms; D016207:Cytokines; D053802:Tryptases