[The role of lung afferent system in respiratory control during head-down tilt].
The role of lung receptors in respiratory control during acute head-down tilt (AHDT, -30 degrees) was investigated in anesthetized, tracheostomized rats. The results show that AHDT increased the mechanical respiratory load, slowed inspiratory flow, reduced the end expiratory lung volume, tidal volume and minute ventilation. On the other hand, during AHDT a significant rise in inspiratory swings of oesophageal pressure was recorded indicated a compensatory increase in inspiratory muscle contraction force. These effects were reduced after transaction of the vagus nerve. It was also shown that respiratory response on added mechanical load was reduced during AHDT as compared with the value in horizontal position. This deference disappeared after vagotomy. The data obtained suggested that afferent information from lung receptors take part in compensation of respiratory effects of AHDT. The cause of reduction in respiratory response to loading during AHDT involves weakness of lung reflexes evoked by volume changes.
Aleksandrova
N P
NP
Donina
Zh A
ZhA
Tikhonov
M A
MA
Baranov
V M
VM
D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D018475:Head-Down Tilt; D008168:Lung / Q000294:innervation* / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration; D014628:Vagotomy; D014630:Vagus Nerve