British Pharmacology Society 2nd Focused meeting on Cell Signalling: GPCRs have sunny days in springtime Leicester.
The British Pharmacology Society recently held its 2nd Focused meeting on Cell Signalling in April 2007 at which a number of leading investigators from throughout the world presented findings that emphasized cellular and molecular aspects of G-protein-coupled receptor (GPCR) biology. Although the presentations highlighted both in vitro and in vivo studies, there was renewed and increased attention paid to systems with physiological (or near-physiological) levels of receptor expression. Mechanisms involved in regulating receptor expression, receptor recognition and activation by different classes of drugs, and in the interaction of G-protein-coupled receptor with other molecular entities, including heterotrimeric G proteins, were major themes of the presentations. Several speakers emphasized the challenges of drug discovery in relation to G-protein-coupled receptor, as well as their continuing importance in pharmacology and therapeutics.
Insel
Paul A
PA
University of California at San Diego, Department of Pharmacology, La Jolla, CA 92093-0636, USA. pinsel@ucsd.edu
D000818:Animals; D002450:Cell Communication; D015195:Drug Design; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
D043562:Receptors, G-Protein-Coupled