title: A study of medication reviews to identify drug-related problems of polypharmacy patients in the Dutch nursing home setting.
abstract: BACKGROUND
  Little is known about the extent of drug-related problems of polypharmacy patients in Dutch nursing homes.
  
  
  OBJECTIVE
  We investigated the feasibility of teams of hospital pharmacists and nursing home physicians carrying out medication reviews. We aimed to identify the number and nature of drug-related problems of nursing home patients receiving more than nine drugs (polypharmacy).
  
  
  METHODS
  The study was carried out in five Dutch nursing homes (n = 742 beds) between October 2005 and May 2006. Ninety-one polypharmacy patients, (average age 80 years) were included. A medication review was carried out by teams consisting of one hospital pharmacist and the patient's nursing home physician with a follow-up meeting of the same team 6 weeks later.
  
  
  RESULTS
  A total of 323 drug-related problems were identified (mean of 3.5 problems per patient). Sixty-two per cent of problems, in 87% of patients, were classified as 'unclear or not confirmed indication or need for review' of the prescribed drug. By the time of the follow-up, a mean of 1.7 (n = 159) problems per patient had been solved and the number of drugs per patient had decreased significantly from 13.5 to 12.7 (P < 0.0001).
  
  
  CONCLUSIONS
  The majority of patients had at least one drug prescribed for which the indication was unknown. The intervention was accompanied by a significant decrease in the number of drugs per patient, but half of the drug-related problems remained unsolved.
authors.affiliation: Department of Pharmacotherapy and Pharmaceutical Care, GUIDE, University of Groningen, Groningen, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Finkers
authors.forename: J G
authors.initials: JG
authors.lastname: Maring
authors.forename: F
authors.initials: F
authors.lastname: Boersma
authors.forename: K
authors.initials: K
authors.lastname: Taxis
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000369:Aged, 80 and over; D017723:Drug Utilization Review; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D009735:Nursing Homes / Q000458:organization & administration*; D010593:Pharmaceutical Services / Q000458:organization & administration; D010595:Pharmacists / Q000458:organization & administration; D010820:Physicians / Q000458:organization & administration; D019338:Polypharmacy