Pioglitazone impurities.
Methods of preparation of API pioglitazone were discussed from the point of view of impurities occurrence. Four real impurities (I-IV) of pioglitazone were prepared and characterized by means of NMR spectroscopy.
Richter
J
J
Department of Technology of Organic Compunds, Faculty of Chemical Technology, Univerzity of Pardubice, Czech Republic. Jindrich.richter@zentiva.cz
Jirman
J
J
Havlícek
J
J
Hrdina
R
R
D004340:Drug Contamination; D007004:Hypoglycemic Agents / Q000032:analysis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D000077205:Pioglitazone; D013329:Structure-Activity Relationship; D045162:Thiazolidinediones / Q000032:analysis* / Q000737:chemistry
D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077205:Pioglitazone