title: Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups.
abstract: One phenol-quaternary ammonium salt derivative with a flexible linker and three derivatives with a quinazoline moiety are present. Their binding affinities for DNA are discussed and it is clearly demonstrated that this class of phenol-quaternary ammonium salt derivatives could inhibit DNA transcription effectively.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University Hubei, Wuhan 430072, PR China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Zhang
authors.forename: Lige
authors.initials: L
authors.lastname: Ren
authors.forename: Minghui
authors.initials: M
authors.lastname: Bai
authors.forename: Liwei
authors.initials: L
authors.lastname: Weng
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.forename: Lin
authors.initials: L
authors.lastname: Wu
authors.forename: Minggang
authors.initials: M
authors.lastname: Deng
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D001665:Binding Sites; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000187:drug effects / Q000235:genetics; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D010636:Phenols / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012492:Salts / Q000737:chemistry; D013696:Temperature; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D003432:Cross-Linking Reagents; D010636:Phenols; D000644:Quaternary Ammonium Compounds; D011799:Quinazolines; D012492:Salts; D004247:DNA