Antidiabetic potential of Phyllanthus reticulatus in alloxan-induced diabetic mice.
The plant Phyllanthus reticulatus is claimed to have antidiabetic activity in tribal area. To validate the tribal claim, the petroleum ether and ethanolic extracts of leaves of the P. reticulatus were orally tested at 500 and 1000 mg/kg for hypoglycemic effect in alloxan induces diabetic mice. It shows antidiabetic activity at the dose of 1000 mg/kg. The phytochemical screening of the residues revealed the presence of terpenoids glycosides, protein, carbohydrates and absence of alkaloids and steroids.
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Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India. sunilmadhuban@yahoo.com
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Deshmukh
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Lokhande
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Rangari
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D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D029803:Phyllanthus; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts