title: Neuroendocrine differentiation of localized prostate cancer during endocrine therapy.
abstract: A 74-year-old male was treated with endocrine therapy for localized prostate cancer. After 25 months he complained of a swollen neck, and was diagnosed with prostate cancer with lymph node metastasis of neuroendocrine differentiation. Neuroendocrine differentiation without elevation of conventional tumor markers is rare during the initial recurrent course of localized prostate cancer.
authors.affiliation: Department of Urology, National Hakodate Hospital, Hakodate, Japan. knemoto@hnh.hosp.go.jp
authors.forename: Kaoru
authors.initials: K
authors.lastname: Nemoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tomita
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D000368:Aged; D000813:Anilides / Q000494:pharmacology / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology / Q000627:therapeutic use; D002454:Cell Differentiation / Q000187:drug effects*; D017273:Goserelin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D009570:Nitriles / Q000494:pharmacology / Q000627:therapeutic use*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D014105:Tosyl Compounds / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000813:Anilides; D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014105:Tosyl Compounds; D017273:Goserelin; C053541:bicalutamide; D017430:Prostate-Specific Antigen