Brunneins A-C, beta-carboline alkaloids from Cortinarius brunneus.
Four beta-carboline alkaloids, brunneins A-C (1-3) and 3-(7-hydroxy-9H-beta-carboline-1-yl)propanoic acid (4), were isolated from fruiting bodies of the agaricoid fungus Cortinarius brunneus. The structures of 1-3 were determined by analysis of NMR and MS data, and the structure of compound 4 was determined by comparison with published data. Brunnein A (1) exhibited very low cholinesterase inhibitory effects and no cytotoxicity.
Teichert
Axel
A
Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle/Saale, Germany.
Schmidt
Jürgen
J
Porzel
Andrea
A
Arnold
Norbert
N
Wessjohann
Ludger
L
D000363:Agaricales / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005858:Germany; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000470:Alkaloids; D002243:Carbolines; D002800:Cholinesterase Inhibitors; C524295:brunnein A; C524296:brunnein B; C524297:brunnein C