title: The effect of atrial septostomy on the concentration of brain-type natriuretic peptide in patients with idiopathic pulmonary arterial hypertension.
abstract: Atrial septostomy has improved haemodynamics and clinical symptoms in selected patients with idiopathic pulmonary arterial hypertension. We found that, in 5 patients with idiopathic pulmonary arterial hypertension, septostomy resulted in decreased levels of brain-type natriuretic peptide, and improvement in symptoms of cardiac failure, suggesting that serial measurements of the peptide may have clinical utility.
authors.affiliation: Columbia University College of Physicians and Surgeons New York, New York, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: O'Byrne
authors.forename: Erika S Berman
authors.initials: ES
authors.lastname: Rosenzweig
authors.forename: Robyn J
authors.initials: RJ
authors.lastname: Barst
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006325:Heart Atria / Q000601:surgery; D006346:Heart Septum / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000601:surgery*; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*
chemical_list: D020097:Natriuretic Peptide, Brain