title: Synthesis, characterization and antibacterial activity of azomethine derivatives derived from 2-formylphenoxyacetic acid.
abstract: A series of eight new azomethine derivatives were synthesized by reacting 2-formylphenoxyacetic acid with aromatic amines. The chemical structures of these compounds were confirmed by means of 1H-NMR, 13C-NMR, MS and elemental analysis. The compounds were assayed by the disc diffusion method for antibacterial against Staphylococcus aureus and Escherichia coli. Among the compounds tested, 2a, 2b, 2e, 2g and 2h exhibited good antibacterial activity, almost equal to that of Ciprofloxacin used as standard.
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore-54590, Pakistan. itsamjid78@yahoo.com
authors.forename: Amjid
authors.initials: A
authors.lastname: Iqbal
authors.forename: Hamid Latif
authors.initials: HL
authors.lastname: Siddiqui
authors.forename: C M
authors.initials: CM
authors.lastname: Ashraf
authors.forename: Matloob
authors.initials: M
authors.lastname: Ahmad
authors.forename: George W
authors.initials: GW
authors.lastname: Weaver
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000085:Acetates; D000890:Anti-Infective Agents; D001391:Azo Compounds; D013882:Thiosemicarbazones; C512188:azomethine; D002939:Ciprofloxacin; C415326:phenoxyacetic acid