title: Handedness and schizotypal features in healthy subjects.
abstract: BACKGROUND
  An excess of mixed-handedness has been repeatedly reported in schizophrenia and schizotypy. Handedness is a measure of atypical cerebral lateralization, which is considered as a risk factor for schizophrenia. Several studies have attempted to identify correlations between handedness and dimensions of psychosis but the results obtained so far remain inconclusive.
  
  
  OBJECTIVE
  To explore a possible link between mixed-handedness and the three classical dimensions of psychosis. As speech and language disorders may be associated with cerebral lateralization, we predicted a correlation between mixed-handedness and disorganized dimension.
  
  
  METHODS
  We used the Schizotypal Personality Questionnaire (SPQ) and the Edinburgh Handedness Inventory (EHI) to study the correlation between mixed-handedness scores and positive, negative or disorganized dimensions in a sample of 62 healthy subjects.
  
  
  RESULTS
  We found a negative correlation between mixed-handedness and the disorganized dimension of schizotypy, as individuals with prominent mixed-handedness showed more severe disorganization.
  
  
  CONCLUSIONS
  We have identified a link between mixed-handedness and the disorganized dimension that may help to identify genetic vulnerability factors involved in psychosis.
authors.affiliation: AP-HP Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie, Créteil, France. schurhof@ext.jussieu.fr
authors.forename: Franck
authors.initials: F
authors.lastname: Schürhoff
authors.forename: Audrey
authors.initials: A
authors.lastname: Laguerre
authors.forename: Isabelle
authors.initials: I
authors.lastname: Roy
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Beaumont
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
mesh_terms: D000328:Adult; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D015995:Prevalence; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires