title: Discovery of potent T-type calcium channel blocker.
abstract: The intensive SAR study of 3,4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC(50)=41+/-1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date.
authors.affiliation: Research Institute for Basic Sciences and Department of Chemistry, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Han Na
authors.initials: HN
authors.lastname: Seo
authors.forename: Ja Youn
authors.initials: JY
authors.lastname: Choi
authors.forename: Yun Jeong
authors.initials: YJ
authors.lastname: Choe
authors.forename: Yoonjee
authors.initials: Y
authors.lastname: Kim
authors.forename: Hyewhon
authors.initials: H
authors.lastname: Rhim
authors.forename: So Ha
authors.initials: SH
authors.lastname: Lee
authors.forename: Jungahn
authors.initials: J
authors.lastname: Kim
authors.forename: Dong Jun
authors.initials: DJ
authors.lastname: Joo
authors.forename: Jae Yeol
authors.initials: JY
authors.lastname: Lee
mesh_terms: D002121:Calcium Channel Blockers / Q000737:chemistry* / Q000494:pharmacology*; D020747:Calcium Channels, T-Type / Q000187:drug effects*; D002460:Cell Line; D006801:Humans; D011799:Quinazolines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D002121:Calcium Channel Blockers; D020747:Calcium Channels, T-Type; D011799:Quinazolines