title: Species-dependent plasma metabolism of the ester compound daidzein 7,4'di-succinic acid mon-ester-O-ethoxy (DZ5).
abstract: Daidzein 7,4'di-succinic acid mon-ester-O-ethoxy (DZ5) is an ester-containing compound, which was recently synthesized. The objective of this study was to determine the hydrolysis rate of DZ5 in blood from the rat and the dog. The data showed that the hydrolysis rate of DZ5 in plasma was much more rapid in rats than in dogs following intravenous administration. Moreover, similar results were observed after in vitro incubation of DZ5 in the rat or dog plasma. The findings suggested that plasma esterases in the rat plasma have higher activity than in the dog and plasma metabolism of DZ5 is species-dependent.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China. xiaohu6408_cn@sina.com
authors.forename: Shujun
authors.initials: S
authors.lastname: Wang
authors.forename: Jingyu
authors.initials: J
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Peng
authors.forename: Yu
authors.initials: Y
authors.lastname: Zou
authors.forename: Huixin
authors.initials: H
authors.lastname: Xiang
authors.forename: Huimin
authors.initials: H
authors.lastname: Yao
authors.forename: Jimin
authors.initials: J
authors.lastname: Chen
authors.forename: Dianzhou
authors.initials: D
authors.lastname: Bi
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yao
mesh_terms: D000818:Animals; D001800:Blood Specimen Collection; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D007202:Indicators and Reagents; D007529:Isoflavones / Q000097:blood* / Q000493:pharmacokinetics; D010949:Plasma / Q000378:metabolism*; D051381:Rats; D015203:Reproducibility of Results; D013045:Species Specificity; D013056:Spectrophotometry, Ultraviolet; D013386:Succinates / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: C515219:7,4'-disuccinic acid monoester-O-ethoxydaidzein; D007202:Indicators and Reagents; D007529:Isoflavones; D013386:Succinates; C004742:daidzein