Managing prolactin-secreting adenomas during pregnancy.
OBJECTIVE
To determine an appropriate approach to managing prolactin-secreting adenomas of varying severity in pregnant women.


METHODS
MEDLINE was searched using the key words "hyperprolactinemia," "prolactinoma," "pregnancy," and "management." Experience from a multidisciplinary tertiary care centre was also reviewed. Recommendations are based on mostly levels II and III evidence.


RESULTS
With appropriate management, most women with hyperprolactinemia can achieve pregnancy. Although most women with prolactin-secreting adenomas during pregnancy need only careful observation, others might require medical treatment or even surgical evacuation. Ideally, such patients should be managed by multidisciplinary teams. In the absence of such teams, most pregnant women with small tumours can be managed safely by their primary physicians. Those with large tumours should be referred to specialists.


CONCLUSIONS
Family physicians play an important role in managing women with prolactinomas during pregnancy. Knowledge of current approaches to management is crucial in determining when and how to refer these patients.
Imran
Syed Ali
SA
Division of Endocrinology and Metabolism, Dalhousie University, Halifax, NS B3H 2Y9. ali.imran@cdha.nshealth.ca
Ur
Ehud
E
Clarke
David B
DB
D000328:Adult; D001971:Bromocriptine / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods; D010821:Physicians, Family; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods; D011379:Prognosis; D015175:Prolactinoma / Q000175:diagnosis / Q000188:drug therapy*; D018570:Risk Assessment
D001971:Bromocriptine