Topical application of mitomycin C in the treatment of esophageal and tracheobronchial stricture: a report of 2 cases.
We present 2 cases of successful treatment of recurrent anastomotic strictures using a topical application of mitomycin C. In the first case, a 4-year-old boy had a cervical cyst excised, which appeared to be an ectopic gastric mucosa. He consequently presented severe stenosis at the origin of the cervical esophagus that needed repeated balloon dilatations. The second case is about a 12-year-old girl who presented a traumatic complete rupture of the right mainstem bronchus managed by primary repair, with subsequent anastomotic stricture. Both patients were successfully managed with topical application of mitomycin C (1 mg/mL), and needed no more dilatations.
Daher
Paul
P
Department of Pediatric Surgery, Hotel Dieu de France Hospital, Beirut, Lebanon. jmpaul@dm.net.lb
Riachy
Edward
E
Georges
Beyrouthy
B
Georges
Dabar
D
Adib
Moukarzel
M
D000287:Administration, Topical; D000714:Anastomosis, Surgical / Q000009:adverse effects; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003251:Constriction, Pathologic / Q000188:drug therapy / Q000209:etiology; D004940:Esophageal Stenosis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D011183:Postoperative Complications; D012008:Recurrence; D014135:Tracheal Stenosis / Q000188:drug therapy* / Q000209:etiology
D016685:Mitomycin