title: Influence of lipids and obesity on haemorheological parameters in patients with deep vein thrombosis.
abstract: It is not well established whether haemorheological alterations constitute independent risk factors for deep vein thrombosis (DVT). We have determined in 149 DVT patients and in 185 control subjects the body mass index (BMI), the haemorheological profile: blood viscosity (BV), plasma viscosity (PV), fibrinogen (Fg), erythrocyte aggregation (EA), erythrocyte deformability (ED) and plasma lipids. In the crude analysis BMI, Fg, PV, EA, triglycerides (TG) and ApoB were statistically higher and HDL cholesterol (HDL-Chol) statistically lower in DVT patients than in controls. No differences in BV and ED were observed. After BMI adjustment, Fg, PV and EA remained statistically higher in DVT cases than in controls (P = 0.013; P = 0.012; P = 0.013; P = 0.028, respectively). When the risk of DVT associated with these variables (using cut-offs that corresponded to the mean plus one SD of the control group) was estimated, EA > 8.2 and PV > 1.28 mPa . s were significantly associated with DVT even further adjustment for lipids and obesity (OR = 2.78, P = 0.004; OR = 1.91, P = 0.024, respectively). However, PV did not remain statistically significant after additional adjustment for Fg. When we consider together all the analyzed variables in order to control every variable for each other, TG > 175 mg/dl (OR = 3,2, P = 0.004) and BMI > 30 kg/m(2) (OR = 3.5, P = 0.003), were also independently associated with a greater risk of DVT. Our results suggest that increased EA constitute an independent risk factor for DVT. However, when associated to hyperlipidaemia and obesity it further increases thrombotic risk.
authors.affiliation: Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Avda. Campanar 21, Valencia 46009, Spain. vaya_amp@gva.es
authors.forename: Amparo
authors.initials: A
authors.lastname: Vayá
authors.forename: Cristina
authors.initials: C
authors.lastname: Falcó
authors.forename: María
authors.initials: M
authors.lastname: Simó
authors.forename: Fernando
authors.initials: F
authors.lastname: Ferrando
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Mira
authors.forename: José
authors.initials: J
authors.lastname: Todolí
authors.forename: Francisco
authors.initials: F
authors.lastname: España
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella
mesh_terms: D000328:Adult; D001809:Blood Viscosity; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood*; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D018056:Hemorheology; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology* / Q000503:physiopathology
chemical_list: D014280:Triglycerides; D005340:Fibrinogen; D002784:Cholesterol