The impact of dengue on liver function as evaluated by aminotransferase levels.
The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A--normal enzyme levels; grade B--increased levels of at least one of the enzymes; grade C--increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D--acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases.
de Souza
Luiz José
LJ
Dengue Reference Center, Oswaldo Cruz Institute, FIOCRUZ, Brazil. sbcm.rol@terra.com.br
Nogueira
Rita Maria Ribeiro
RM
Soares
Leandro Cordeiro
LC
Soares
Carlos Eduardo Cordeiro
CE
Ribas
Bruno Fernandes
BF
Alves
Felipe Pinto
FP
Vieira
Fabíola Rodrigues
FR
Pessanha
Felipe Eulálio Baldi
FE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D003715:Dengue / Q000201:enzymology* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology* / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D019595:Severe Dengue / Q000201:enzymology / Q000503:physiopathology; D012720:Severity of Illness Index
D015415:Biomarkers; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase