Acute decrease of coronary flow after indomethacin delivery in newborn lambs.
OBJECTIVE
To document the effects of indomethacin (IND) on coronary flow.


METHODS
We studied nine premature lambs during the first day of life. The gestational age varied between 132 and 134 days (term 145 days) and weight 3.1-4.7 kg. Coronary flow velocities were recorded with an intracoronary Doppler guide wire in the proximal left anterior descending coronary artery (LAD). Average peak flow velocity was measured before, during and after an intravenous IND injection of 0.2 mg per kilogram of body weight.


RESULTS
IND increased systemic blood pressure (p < 0.05) and rate pressure product (RPP; p < 0.05) indicating that IND increased cardiac workload. IND decreased coronary average peak flow velocity in all lambs (p < 0.05). The maximal fall in coronary velocity appeared after 3 min (range 1-7 min) and was regained 10 min (range 4-53 min) after the drug delivery. The maximal reduction of coronary average peak flow velocity was 52% (median 26). The recovery time was directly related to the maximal reduction of the coronary average peak flow velocity (R = 0.91, R(2) 0.84, p < 0.002).


CONCLUSIONS
Coronary flow velocity decreased markedly in premature born lambs given a bolus dose of IND.
Harling
Solweig
S
Department of Paediatrics, University Hospital, Lund, Sweden. solweig.harling@med.lu.se
Oskarsson
Gylfi
G
Gudmundsson
Saemundur
S
Pesonen
Erkki
E
D000208:Acute Disease; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D023421:Models, Animal; D015425:Myocardial Reperfusion; D009206:Myocardium; D012756:Sheep; D013997:Time Factors
D007213:Indomethacin