title: TP53 codon 72 polymorphism, p53 expression, and 1p/19q status in oligodendroglial tumors.
abstract: The functional single-nucleotide polymorphism (SNP) in codon 72 of TP53 has been shown to be both a risk factor and a prognostic biomarker in various cancers. Such results were also reported in brain tumors, notably in astrocytomas. This SNP has never been precisely investigated in oligodendroglial tumors. We retrospectively analyzed blood samples of 275 oligodendroglial tumor patients for the TP53 codon 72 polymorphism and compared them with a series of 144 healthy controls. Arg/Arg, Arg/Pro, and Pro/Pro genotypes were found in 54.2 versus 60.4%, 39.3 versus 34.0%, and 7.3 versus 5.6% of patients and controls, respectively. This suggests no association between oligodendroglial tumors and the SNP in codon 72 of TP53. Similarly, no correlation was found among the TP53 codon 72 polymorphism and prognosis, p53 expression, and chromosomes 1p and 19q status.
authors.affiliation: INSERM, Unité 711, Groupe hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France. ahmed.idbaih@neuf.fr
authors.forename: Ahmed
authors.initials: A
authors.lastname: Idbaih
authors.forename: Blandine
authors.initials: B
authors.lastname: Boisselier
authors.forename: Yannick
authors.initials: Y
authors.lastname: Marie
authors.forename: Soufiane
authors.initials: S
authors.lastname: El Hallani
authors.forename: Marc
authors.initials: M
authors.lastname: Sanson
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Crinière
authors.forename: Mathieu
authors.initials: M
authors.lastname: Rodero
authors.forename: Catherine
authors.initials: C
authors.lastname: Carpentier
authors.forename: Sophie
authors.initials: S
authors.lastname: Paris
authors.forename: Florence
authors.initials: F
authors.lastname: Laigle-Donadey
authors.forename: François
authors.initials: F
authors.lastname: Ducray
authors.forename: Khê
authors.initials: K
authors.lastname: Hoang-Xuan
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Delattre
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000235:genetics / Q000378:metabolism; D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D003062:Codon; D004273:DNA, Neoplasm / Q000097:blood / Q000235:genetics / Q000378:metabolism; D005260:Female; D005838:Genotype; D005910:Glioma / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009837:Oligodendroglioma / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
chemical_list: D003062:Codon; D004273:DNA, Neoplasm; D016159:Tumor Suppressor Protein p53