title: Inhibition of mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of spatial memory.
abstract: Using two different mRNA synthesis inhibitors, we show that blockade of hippocampal gene expression during restricted posttraining or postretrieval time windows hinders retention of long-term spatial memory for the Morris water maze task, without affecting short-term memory, nonspatial learning, or the functionality of the hippocampus. Our results indicate that spatial memory consolidation induces the activation of the hippocampal transcriptional machinery and suggest the existence of a gene expression-dependent reconsolidation process that operates in the dorsal hippocampus at the moment of retrieval to stabilize the reactivated mnemonic trace.
authors.affiliation: Centro de Memória, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul, Av. Ipiranga 6690, Porto Alegre, Rio Grande do Sul, Brasil.
authors.forename: Weber C
authors.initials: WC
authors.lastname: Da Silva
authors.forename: Juliana S
authors.initials: JS
authors.lastname: Bonini
authors.forename: Lia R M
authors.initials: LR
authors.lastname: Bevilaqua
authors.forename: Jorge H
authors.initials: JH
authors.lastname: Medina
authors.forename: Iván
authors.initials: I
authors.lastname: Izquierdo
authors.forename: Martín
authors.initials: M
authors.lastname: Cammarota
mesh_terms: D053959:Alpha-Amanitin / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D004004:Dichlororibofuranosylbenzimidazole / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000503:physiopathology*; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D013037:Spatial Behavior / Q000502:physiology*
chemical_list: D053959:Alpha-Amanitin; D019384:Nucleic Acid Synthesis Inhibitors; D012333:RNA, Messenger; D004004:Dichlororibofuranosylbenzimidazole