title: Facile synthesis of optically active imidazole derivatives.
abstract: Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding alpha-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imidazole derivatives. The derivatives thus prepared are structurally-related to histamine.
authors.affiliation: Department of Organic Chemistry, Faculty of Chemical Technology, University of Pardubice, nam. Cs. legii 565, Pardubice, 53210, Czech Republic.
authors.forename: Ales
authors.initials: A
authors.lastname: Marek
authors.forename: Jiri
authors.initials: J
authors.lastname: Kulhanek
authors.forename: Miroslav
authors.initials: M
authors.lastname: Ludwig
authors.forename: Filip
authors.initials: F
authors.lastname: Bures
mesh_terms: D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
chemical_list: D007093:Imidazoles; D008024:Ligands