Linear, redox modified DNA probes as electrochemical DNA sensors.
We show here that hybridization-linked changes in the dynamics of a redox-modified, electrode-bound linear (as opposed to stem-loop) probe DNA produce large changes in Faradaic current, allowing for the ready detection of target oligonucleotides.
Ricci
Francesco
F
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.
Lai
Rebecca Y
RY
Plaxco
Kevin W
KW
D015374:Biosensing Techniques / Q000379:methods; D004247:DNA / Q000032:analysis*; D015342:DNA Probes / Q000138:chemical synthesis* / Q000737:chemistry; D004563:Electrochemistry; D009838:Oligodeoxyribonucleotides / Q000032:analysis*
D015342:DNA Probes; D009838:Oligodeoxyribonucleotides; D004247:DNA