title: Zinc supplement on tissue arsenic concentration in rats.
abstract: To examine the effect of zinc in the removal of accumulated arsenic from different tissues (liver, kidneys, spleen and lungs), rats were initially allowed to drink high concentration (400 microg/kg/day) of arsenic for two months followed by a period of cessation (one month). Administration of zinc (2 mg/kg/day) during the third month in arsenic-treated and non-treated groups were compared. In arsenic-treated rats, the mean (+/- SD) amounts of total arsenic in liver, kidneys, spleen and lungs were 12.3 +/- 0.7, 20.5 +/- 1.0, 31.4 +/- 1.0 and 25.6 +/- 1.1 microg/g of tissues respectively. Administration of zinc to arsenic-treated rats reduced the arsenic concentrations of those tissues to 7.8, 10.7, 23.0 and 14.0 microg/g of tissues. This in vivo study suggests that zinc removes the accumulated arsenic from different tissues significantly (p < 0.001).
authors.affiliation: Deptt. of Pharmacology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka.
authors.forename: M
authors.initials: M
authors.lastname: Kamaluddin
authors.forename: M
authors.initials: M
authors.lastname: Misbahuddin
mesh_terms: D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D020261:Arsenic Poisoning / Q000517:prevention & control; D019587:Dietary Supplements; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008168:Lung / Q000187:drug effects*; D008297:Male; D019216:Metals, Heavy; D051381:Rats; D020318:Rats, Long-Evans; D013154:Spleen / Q000187:drug effects*; D015032:Zinc / Q000494:pharmacology*
chemical_list: D019216:Metals, Heavy; D015032:Zinc; D001151:Arsenic