title: Synthesis and antioxidant activity evaluation of new hexahydropyrimido[5,4-c]quinoline-2,5-diones and 2-thioxohexahydropyrimido[5,4-c]quinoline-5-ones obtained by Biginelli reaction in two steps.
abstract: New hexahydropyrimido[5,4-c]quinoline-2,5-diones and 2-thioxohexahydropyrimido[5,4-c]quinoline-5-ones were prepared in two steps from ethyl 4-phenyl-6-methyl-2-oxo tetrahydropyrimidine-5-carboxylates or 4-phenyl-6-methyl-2-thioxotetrahydropyrimidine-5-carboxylates, previously prepared by Biginelli reaction using appropriate aldehyde, urea derivatives and ethyl acetoacetate. Their antioxidant properties were evaluated by two methods: scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and scavenging effect on hydroxyl radicals. The results show that the compounds containing thiourea moiety have better activity.
authors.affiliation: Equipe Sciences séparatives et Biopharmaceutique (2SB), Laboratoire de chimie thérapeutique, Faculté de Medecine et de Pharmacie, 4, place Saint Jacques - 25030 Besançon Cedex, France. lhassane.ismaili@univ-fcomte.fr
authors.forename: Lhassane
authors.initials: L
authors.lastname: Ismaili
authors.forename: Arulraj
authors.initials: A
authors.lastname: Nadaradjane
authors.forename: Laurence
authors.initials: L
authors.lastname: Nicod
authors.forename: Catherine
authors.initials: C
authors.lastname: Guyon
authors.forename: Alain
authors.initials: A
authors.lastname: Xicluna
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Robert
authors.forename: Bernard
authors.initials: B
authors.lastname: Refouvelet
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D015363:Quinolones; D017665:Hydroxyl Radical