title: Synthesis of novel anilinoquinolines as c-fms inhibitors.
abstract: A novel series of potent substituted anilinoquinolines were discovered as c-fms inhibitors. The potency could be manipulated upon modification of the C4 aniline and C7 aryl functionality. Pharmacokinetic analysis identified a metabolically stable analog suitable for further investigative work.
authors.affiliation: GlaxoSmithKline, Inc., Five Moore Drive, Research Triangle Park, NC 27709, USA. terry.l.smalley@gsk.com
authors.forename: Terrence L
authors.initials: TL
authors.lastname: Smalley
authors.forename: Stanley D
authors.initials: SD
authors.lastname: Chamberlain
authors.forename: Wendy Y
authors.initials: WY
authors.lastname: Mills
authors.forename: David L
authors.initials: DL
authors.lastname: Musso
authors.forename: Sab A
authors.initials: SA
authors.lastname: Randhawa
authors.forename: John A
authors.initials: JA
authors.lastname: Ray
authors.forename: Vicente
authors.initials: V
authors.lastname: Samano
authors.forename: Lloyd
authors.initials: L
authors.lastname: Frick
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D000818:Animals; D001665:Binding Sites; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D020128:Inhibitory Concentration 50; D023421:Models, Animal; D008958:Models, Molecular; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D000814:Aniline Compounds; D011804:Quinolines; D016186:Receptor, Macrophage Colony-Stimulating Factor; C023650:aniline