title: Renierosides, cerebrosides from a marine sponge Haliclona (Reniera) sp.
abstract: Guided by the brine shrimp lethality assay, eight new cerebrosides (1-8) have been isolated from an extract of the marine sponge Haliclona (Reniera) sp. A novel feature of these cerebrosides was the presence of unprecedented amide-linked long-chain fatty acid moieties. The planar structures of the cerebrosides (1-8) were established by 1D and 2D NMR spectroscopic techniques, mass spectrometric analyses, and chemical degradation methods. The isolated compounds did not display cytotoxicity to a panel of five human solid tumor cell lines.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea.
authors.forename: Tayyab A
authors.initials: TA
authors.lastname: Mansoor
authors.forename: Pramod B
authors.initials: PB
authors.lastname: Shinde
authors.forename: Xuan
authors.initials: X
authors.lastname: Luo
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-O
authors.initials: CO
authors.lastname: Lee
authors.forename: Chung Ja
authors.initials: CJ
authors.lastname: Sim
authors.forename: Byeng Wha
authors.initials: BW
authors.lastname: Son
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047129:Haliclona / Q000737:chemistry*; D006801:Humans; D007723:Korea; D015394:Molecular Structure
chemical_list: D002554:Cerebrosides; D006027:Glycosides