Taxodistines A and B, abietane-type diterpenes from Taxodium distichum.
Two new abietane-type diterpenes, taxodistines A (1) and B (2), have been isolated by the guidance of inhibitory effect of tubulin polymerization from the fruits of Taxodium distichum and the structures were elucidated by using 2D NMR data. Taxodistine B (2) showed inhibition of tubulin polymerization.
Hirasawa
Yusuke
Y
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
Izawa
Emi
E
Matsuno
Yosuke
Y
Kawahara
Nobuo
N
Goda
Yukihiro
Y
Morita
Hiroshi
H
D000818:Animals; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D032489:Taxodium / Q000737:chemistry*
D004224:Diterpenes; C526163:taxodistine A; C526164:taxodistine B