A dual near-infrared pH fluorescent probe and its application in imaging of HepG2 cells.
A dual near-infrared pH fluorescent probe has been designed, synthesized and applied to HepG2 cells, with a pK(a) value of 5.14 under acidic conditions and 11.31 under basic conditions, which is valuable for studying acidic organelles in living cells and pH changes in chemical systems.
Tang
Bo
B
College of Chemistry, Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Shandong Normal University, Jinan 250014, P. R. China. tangb@sdnu.edu.cn
Liu
Xia
X
Xu
Kehua
K
Huang
Hui
H
Yang
Guiwen
G
An
Liguo
L
D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D051272:Glucose Transporter Type 1; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D015335:Molecular Probes; D015394:Molecular Structure; D019265:Spectroscopy, Near-Infrared / Q000379:methods
D005456:Fluorescent Dyes; D051272:Glucose Transporter Type 1; D015335:Molecular Probes; C495677:SLC2A1 protein, human