title: Pneumococcal bacteremia among infants with fever without known source before and after introduction of pneumococcal conjugate vaccine in the Basque Country of Spain.
abstract: BACKGROUND
  The introduction of vaccination with the heptavalent pneumococcal conjugate vaccine (PCV7) has produced an important decrease in the incidence of Streptococcus pneumoniae occult bacteremia (OB). In Spain, PCV7 became available in the last months of 2001, but, to date, it has not been included in the official vaccination schedule of the public health system.
  
  
  OBJECTIVE
  To describe the impact of pneumococcal vaccination with PCV7 on the incidence of OB caused by S. pneumoniae in infants aged 3-36 months presenting to our pediatric emergency department.
  
  
  METHODS
  This is a retrospective case series of all blood cultures obtained from January 1, 2000 to December 31, 2005 in our pediatric emergency department from infants with fever without known source. We evaluated rates of blood cultures positive with S. pneumoniae before (January 1, 2000-December 31, 2001) and after (January 1, 2004-December 31, 2005) PCV7 introduction, excluding 2 transitional years (January 1, 2002-December 31, 2003).
  
  
  RESULTS
  Implementation of vaccination with PVC7 in our area resulted in a 57.5% reduction of OB caused by S. pneumoniae (1.62-0.69%) (P < 0.05). There were 30 cases of bacteremia caused by S. pneumoniae, 19 before and 11 after PCV7 introduction. Between the 2 periods of time studied the number of cases of infants aged 3-36 months with fever without known source, increased from 8052 to 9799 (21.6%) and the total blood cultures drawn significantly increased from 1171 to 1575 (34.5%) (P < 0.01). Despite more frequent blood culturing in febrile patients, the rate of OB caused by PCV7-serotypes decreased significantly by 79% (1.19-0.25%) (P < 0.01) and the proportion of OB caused by nonvaccine serotypes increased minimally from 0.42 to 0.44%. In the post-PVC7 period, 4 infants presented with S. pneumoniae OB caused by PCV7 serotypes; 2 had not received PCV7, and 2 (6 and 7 months old) had received one dose.
  
  
  CONCLUSIONS
  After PCV7 introduction in our area, rates of S. pneumoniae OB caused by vaccine serotypes decreased significantly despite only moderate use of the vaccine in our population.
authors.affiliation: Pediatric Emergency Department, Hospital de Cruces, Bizkaia, Spain. jbenito@hcru.osakidetza.net
authors.forename: Javier
authors.initials: J
authors.lastname: Benito-Fernández
authors.forename: Santiago Mintegi
authors.initials: SM
authors.lastname: Raso
authors.forename: Itziar
authors.initials: I
authors.lastname: Pocheville-Gurutzeta
authors.forename: Jesús
authors.initials: J
authors.lastname: SánchezEtxaniz
authors.forename: Beatriz
authors.initials: B
authors.lastname: Azcunaga-Santibañez
authors.forename: Susana
authors.initials: S
authors.lastname: Capapé-Zache
mesh_terms: D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology*; D002675:Child, Preschool; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology*; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D022401:Meningococcal Vaccines / Q000276:immunology*; D011008:Pneumococcal Infections / Q000453:epidemiology*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D013296:Streptococcus pneumoniae / Q000145:classification / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines