Interleukin-7 enhances proliferation responses to T-cell receptor stimulation in naïve CD4+ T cells from human immunodeficiency virus-infected persons.
Proliferation responses of naïve CD4(+) T cells to T-cell receptor and interleukin-7 (IL-7) stimulation were evaluated by using cells from human immunodeficiency virus-positive (HIV(+)) donors. IL-7 enhanced responses to T-cell receptor stimulation, and the magnitude of this enhancement was similar in cells from healthy controls and from HIV(+) subjects. The overall response to T-cell receptor stimulation alone or in combination with IL-7, however, was diminished among viremic HIV(+) donors and occurred independent of antigen-presenting cells. Frequencies of CD127(+) cells were related to the magnitudes of proliferation enhancement that were mediated by IL-7. Thus, IL-7 enhances but does not fully restore the function of naïve CD4(+) T cells from HIV-infected persons.
Bazdar
Douglas A
DA
Department of Medicine, Division of Infectious Diseases, Center for AIDS Research, Case Western Reserve University, Cleveland, OH 44106, USA.
Sieg
Scott F
SF
D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000821:virology; D049109:Cell Proliferation; D006678:HIV; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D015851:Interleukin-7 / Q000494:pharmacology / Q000502:physiology*; D053699:Interleukin-7 Receptor alpha Subunit / Q000032:analysis; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000819:agonists / Q000276:immunology*
D015851:Interleukin-7; D053699:Interleukin-7 Receptor alpha Subunit; D011948:Receptors, Antigen, T-Cell