title: Toward the human genotope.
abstract: The human genotope is the convex hull of all allele frequency vectors that can be obtained from the genotypes present in the human population. In this paper, we take a few initial steps toward a description of this object, which may be fundamental for future population based genetics studies. Here we use data from the HapMap Project, restricted to two ENCODE regions, to study a subpolytope of the human genotope. We study three different approaches for obtaining informative low-dimensional projections of this subpolytope. The projections are specified by projection onto few tag SNPs, principal component analysis, and archetypal analysis. We describe the application of our geometric approach to identifying structure in populations based on single nucleotide polymorphisms.
authors.affiliation: Department of Mathematics, University of California at Berkeley, Berkeley, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Huggins
authors.forename: Lior
authors.initials: L
authors.lastname: Pachter
authors.forename: Bernd
authors.initials: B
authors.lastname: Sturmfels
mesh_terms: D014644:Genetic Variation; D015894:Genome, Human; D023281:Genomics / Q000706:statistics & numerical data; D005838:Genotype; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis