title: Cd (II) stress response during the growth of Aspergillus niger B 77.
abstract: OBJECTIVE
  To investigate the relationship between growth, heavy metal ions uptake and participation of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in the protection of Aspergillus niger B 77 against cadmium stress.
  
  
  RESULTS
  The stress response of the model fungal strain, under conditions of a wide range of Cd (II) ion concentrations, was investigated by determining the biomass formation, protein biosynthesis, SOD and CAT activities and heavy metal uptake in growing cells. Exposure to heavy metal ions induced an increase in protein content, heavy metal uptake and SOD activity, and a heavy decrease in CAT activity.
  
  
  CONCLUSIONS
  The results obtained indicated that the tolerance of A. niger to Cd (II) was correlated with the heavy metal uptake, reactive oxygen species generation in the cells and the efficiency of antioxidative defence system.
  
  
  CONCLUSIONS
  Evidence is provided for the possibility that oxidative stress plays a major role in the effect of Cd (II) ions on A. niger. These data could offer useful information when creating new strategies and methodological improvements for bioremediation with the participation of fungi.
authors.affiliation: The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: D
authors.initials: D
authors.lastname: Todorova
authors.forename: D
authors.initials: D
authors.lastname: Nedeva
authors.forename: R
authors.initials: R
authors.lastname: Abrashev
authors.forename: K
authors.initials: K
authors.lastname: Tsekova
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001234:Aspergillus niger / Q000201:enzymology / Q000254:growth & development*; D001673:Biodegradation, Environmental; D002104:Cadmium / Q000633:toxicity*; D002374:Catalase / Q000032:analysis / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism; D009172:Mycology; D018384:Oxidative Stress; D012989:Soil Pollutants / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005656:Fungal Proteins; D012989:Soil Pollutants; D002104:Cadmium; D002374:Catalase; D013482:Superoxide Dismutase