Matrix metalloproteinase-2 promoter polymorphism is associated with breast cancer in a Mexican population.
BACKGROUND
Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity on matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism C>T transition at -1306 displayed a strong association with several cancers. Our study investigated whether or not the MMP-2 -1306C>T polymorphism contributed to the development of breast cancer (BC) in a Mexican population.


METHODS
90 patients with BC and 96 control subjects were analyzed to detect MMP-2 -1306C>T polymorphism.


RESULTS
The frequency of MMP-2 CC genotype was significantly higher in BC patients when compared with the control group (OR 2.15; 95% CI 1.1-4.1). MMP-2 CC genotype frequency was more pronounced in younger subjects (< or =50 years) at diagnosis (OR 2.66; 95% CI 1.04-6.96).


CONCLUSIONS
The data suggest that MMP-2 -1306C>T polymorphism strongly contributes to the development of BC in the population studied, especially among women 50 years old and younger.
Delgado-Enciso
Iván
I
School of Medicine, Universidad de Colima, Colima, Col., Mexico. ivan_delgado_enciso@ucol.mx
Cepeda-Lopez
Friedman R
FR
Monrroy-Guizar
Elisa A
EA
Bautista-Lam
Jose R
JR
Andrade-Soto
Maricela
M
Jonguitud-Olguin
Gregorio
G
Rodriguez-Hernandez
Alejandrina
A
Anaya-Ventura
Aristoteles
A
Baltazar-Rodriguez
Luz M
LM
Orozco-Ruiz
Martha
M
Soriano-Hernandez
Alejandro D
AD
Rodriguez-Sanchez
Iram P
IP
Lugo-Trampe
Angel
A
Espinoza-Gomez
Francisco
F
Michel-Peregrina
Martha L
ML
D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D017058:Mexican Americans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2