Glycosidase inhibitors as conformational transition state analogues.
A method for estimating the conformational similarity between hexopyranose rings is presented and used to probe the behaviour of various glycosyl hydrolase inhibitors as conformational transition state analogues.
Greig
Ian R
IR
Department of Chemistry, University of Bath, Bath, UK. i.greig@bath.ac.uk
Williams
Ian H
IH
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry* / Q000493:pharmacokinetics; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000493:pharmacokinetics; D015394:Molecular Structure
D004791:Enzyme Inhibitors; D006027:Glycosides; D006026:Glycoside Hydrolases