title: Bis(4-hydroxybenzyl)sulfide: a sulfur compound inhibitor of histone deacetylase isolated from root extract of Pleuropterus ciliinervis.
abstract: A sulfur compound, bis(4-hydroxybenzyl)sulfide (1) was isolated from the root extract of Pleuropterus ciliinervis. Its structure was elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 1 showed potent inhibitory activity in a histone deacetylase (HDAC) enzyme assay. It also exhibited growth inhibitory activity on five human tumor cell lines and more sensitive inhibitory activity on the MDA-MB-231 breast tumor cell line.
authors.affiliation: Department of Neuroscience and Inam Neuro Science Research Center, Wonkwang University, Gunpo-city, Kyunggido, 435-040, South Korea.
authors.forename: Il Hong
authors.initials: IH
authors.lastname: Son
authors.forename: Sung Ik
authors.initials: SI
authors.lastname: Lee
authors.forename: Hyun Duk
authors.initials: HD
authors.lastname: Yang
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000737:chemistry*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D008956:Models, Chemical; D010936:Plant Extracts / Q000378:metabolism*; D018517:Plant Roots / Q000378:metabolism; D012680:Sensitivity and Specificity; D013440:Sulfides / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*; D013457:Sulfur Compounds / Q000737:chemistry*; D013778:Tetrazolium Salts / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D010936:Plant Extracts; D013440:Sulfides; D013457:Sulfur Compounds; D013778:Tetrazolium Salts; D013844:Thiazoles; C477166:bis(4-hydroxybenzyl)sulfide; D013455:Sulfur; D006655:Histone Deacetylases; C022616:thiazolyl blue