[Advances and limitations in the early diagnosis of invasive yeast infections].
In the last years, the main advances in the serological diagnosis of mycoses caused by yeasts have occurred in the area of antibody and (1-3)-beta-D-glucan detection. Commercialization of the Candida albicans IFA IgG test and detection of antibodies against recombinant antigens Hwp1 and enolase are the most important contributions to the first area. Detection of (1-3)-beta-D-glucan confirms its usefulness as a good marker for the diagnosis of invasive candidiasis. The most recent studies suggest that combination of two tests to detect antígen, antibodies, (1-3)-beta-D-glucan and DNA will be needed to optimize the diagnosis of systemic yeast infections.
Pontón
José
J
Laboratorio de Micología Médica, Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao, Spain. jose.ponton@ehu.es
del Palacio
Amalia
A
D000908:Antibodies, Fungal / Q000097:blood; D000946:Antigens, Fungal / Q000097:blood; D015415:Biomarkers; D002176:Candida albicans / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D002177:Candidiasis / Q000097:blood / Q000175:diagnosis; D004271:DNA, Fungal / Q000097:blood; D042241:Early Diagnosis; D016469:Fungemia / Q000097:blood / Q000175:diagnosis / Q000382:microbiology; D006801:Humans; D009181:Mycoses / Q000097:blood / Q000175:diagnosis* / Q000382:microbiology; D011509:Proteoglycans; D015003:Yeasts / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D047071:beta-Glucans / Q000097:blood
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D015415:Biomarkers; D004271:DNA, Fungal; D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K