title: Fixed dose prothrombin complex concentrate for the reversal of oral anticoagulation therapy.
abstract: Warfarin reversal is frequently required in day to day haematology practice. Prothrombin complex concentrates (PCC) have replaced fresh frozen plasma as the agent of choice in warfarin reversal due to its safety profile. Ideal dose of PCC is still not known and many centres have local guidelines on using the product. We have successfully used PCC (Beriplex) at a fixed dose in our hospital, but we still need randomised control trials to identify the ideal dose of PCC which can result in rapid reversal of warfarin with minimum risk of thrombosis.
authors.affiliation: Department of Haematology, Eastbourne District General Hospital, Eastbourne, East Sussex, UK. pritjun@rediffmail.com
authors.forename: P
authors.initials: P
authors.lastname: Junagade
authors.forename: R
authors.initials: R
authors.lastname: Grace
authors.forename: P
authors.initials: P
authors.lastname: Gover
mesh_terms: D000931:Antidotes; D001779:Blood Coagulation Factors / Q000008:administration & dosage* / Q000009:adverse effects; D054869:Clinical Audit; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000188:drug therapy*; D006801:Humans; D019934:International Normalized Ratio; D016896:Treatment Outcome; D014859:Warfarin / Q000633:toxicity*
chemical_list: D000931:Antidotes; D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates; D014859:Warfarin