title: Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients.
abstract: Frequency domain optical coherence tomography (FD-OCT), based on an all-reflective high-speed InGaAs spectrometer, operating in the 1050 nm wavelength region for retinal diagnostics, enables high-speed, volumetric imaging of retinal pathologies with greater penetration into choroidal tissue is compared to conventional 800 nm three-dimensional (3-D) ophthalmic FD-OCT systems. Furthermore, the lower scattering at this wavelength significantly improves imaging performance in cataract patients, thereby widening the clinical applicability of ophthalmic OCT. The clinical performance of two spectrometer-based ophthalmic 3-D OCT systems compared in respect to their clinical performance, one operating at 800 nm with 150 nm bandwidth (approximately 3 microm effective axial resolution) and the other at 1050 nm with 70 nm bandwidth (approximately 7 microm effective axial resolution). Results achieved with 3-D OCT at 1050 nm reveal, for the first time, decisive improvements in image quality for patients with retinal pathologies and clinically significant cataract.
authors.affiliation: Cardiff University, School of Optometry and Vision Sciences, Biomedical Imaging Group, Cardiff, Wales, CF24 4LU, United Kingdom.
authors.forename: Boris
authors.initials: B
authors.lastname: Povazay
authors.forename: Boris
authors.initials: B
authors.lastname: Hermann
authors.forename: Angelika
authors.initials: A
authors.lastname: Unterhuber
authors.forename: Bernd
authors.initials: B
authors.lastname: Hofer
authors.forename: Harald
authors.initials: H
authors.lastname: Sattmann
authors.forename: Florian
authors.initials: F
authors.lastname: Zeiler
authors.forename: James E
authors.initials: JE
authors.lastname: Morgan
authors.forename: Christiane
authors.initials: C
authors.lastname: Falkner-Radler
authors.forename: Carl
authors.initials: C
authors.lastname: Glittenberg
authors.forename: Susanne
authors.initials: S
authors.lastname: Blinder
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Drexler
mesh_terms: D000465:Algorithms; D002386:Cataract / Q000473:pathology*; D002829:Choroid / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D015203:Reproducibility of Results; D012160:Retina / Q000473:pathology; D012164:Retinal Diseases / Q000473:pathology*; D042262:Retinoscopy / Q000379:methods*; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000379:methods; D041623:Tomography, Optical Coherence / Q000379:methods*