title: Enol esters: versatile substrates for Mannich-type multicomponent reactions.
abstract: The interaction of cyclic enol esters with diversely substituted anilines and ethyl glyoxalate yields, under Sc(OTf)3 catalysis, disubstituted N-aryl lactams in a multicomponent reaction. The protocol allows access to the trans stereoisomers after an epimerization of the initial mixture in which the cis isomers predominate. Vinyl acetate yields quinoline derivatives, whereas isopropenyl acetate leads to the corresponding Mannich adducts.
authors.affiliation: Institute for Research in Biomedicine, Barcelona Science Park, Josep Samitier 1-5, 08028 Barcelona, Spain.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Isambert
authors.forename: Montse
authors.initials: M
authors.lastname: Cruz
authors.forename: María José
authors.initials: MJ
authors.lastname: Arévalo
authors.forename: Elena
authors.initials: E
authors.lastname: Gómez
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Lavilla
mesh_terms: D002384:Catalysis; D004952:Esters; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis; D013237:Stereoisomerism
chemical_list: D004952:Esters; D007769:Lactams; D011804:Quinolines