title: Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase.
abstract: Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents.
authors.affiliation: Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand. cnisachon@yahoo.com
authors.forename: Nisachon
authors.initials: N
authors.lastname: Khunnawutmanotham
authors.forename: Nitirat
authors.initials: N
authors.lastname: Chimnoi
authors.forename: Patchareenart
authors.initials: P
authors.lastname: Saparpakorn
authors.forename: Pornpan
authors.initials: P
authors.lastname: Pungpo
authors.forename: Suda
authors.initials: S
authors.lastname: Louisirirotchanakul
authors.forename: Supa
authors.initials: S
authors.lastname: Hannongbua
authors.forename: Supanna
authors.initials: S
authors.lastname: Techasakul
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002478:Cells, Cultured; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D015497:HIV-1 / Q000201:enzymology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D001381:Azepines; D054303:HIV Reverse Transcriptase