Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity.
Shie
Jiun-Jie
JJ
The Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
Fang
Jim-Min
JM
Wang
Shi-Yun
SY
Tsai
Keng-Chang
KC
Cheng
Yih-Shyun E
YS
Yang
An-Suei
AS
Hsiao
Shih-Chia
SC
Su
Ching-Yao
CY
Wong
Chi-Huey
CH
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D004285:Dogs; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000201:enzymology; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects* / Q000201:enzymology; D007700:Kinetics; D008958:Models, Molecular; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D053139:Oseltamivir / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D063065:Organophosphonates; D053139:Oseltamivir; D009439:Neuraminidase