title: Promoter polymorphism of IL-18 gene in pulmonary tuberculosis in South Indian population.
abstract: Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at -607(C/A) and -137(G/A) in the promoter region of IL-18 gene by allele-specific polymerase chain reaction in normal healthy subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, genotype and haplotype frequencies did not differ significantly between normal healthy subjects and patients. The results suggest that the IL-18 gene promoter polymorphisms are not associated with susceptibility or resistance to pulmonary tuberculosis in south Indian population of Dravidian descent.
authors.affiliation: Tuberculosis Research Center, Indian Council of Medical Research, Chetput, Chennai, India.
authors.forename: M
authors.initials: M
authors.lastname: Harishankar
authors.forename: P
authors.initials: P
authors.lastname: Selvaraj
authors.forename: D N
authors.initials: DN
authors.lastname: Rajeswari
authors.forename: S P
authors.initials: SP
authors.lastname: Anand
authors.forename: P R
authors.initials: PR
authors.lastname: Narayanan
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India / Q000208:ethnology; D020382:Interleukin-18 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: D020382:Interleukin-18