Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide.
A novel [18F]NF reagent and two novel radiochemical transformations have been developed: [18F]NFSi has been prepared from sodium dibenzenesulfonimide and reacted in the presence of silyl enol ethers and allylsilanes to deliver labelled fluorinated ketones and allylic fluorides respectively; the radiosynthesis of the fluorinated A ring of vitamin D3 has also been completed with success.
Teare
Harriet
H
Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK OX1 3TA.
Robins
Edward G
EG
Arstad
Erik
E
Luthra
Sajinder K
SK
Gouverneur
Véronique
V
D002851:Chromatography, High Pressure Liquid; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D011874:Radiometry; D013449:Sulfonamides / Q000138:chemical synthesis*; D000096926:Benzenesulfonamides
D005462:Fluorine Radioisotopes; D013449:Sulfonamides; C523711:N-fluorobenzenesulfonimide; D000096926:Benzenesulfonamides