VEGF receptor Flk-1 plays an important role in c-kit expression in adipose tissue derived stem cells.
It is known that c-kit(+) cells are increased in heart after infarction. The exact origins of the cardiac c-kit(+) cells remain to be determined. We asked whether adipose tissue could be a potential source of c-kit(+) cells. Our data show that the number of c-kit(+) cells increased in adipose tissue derived stem cells when cultured with conditioned medium from neonatal cardiomyocytes grown under serum deprivation and hypoxia condition. We also found that VEGF receptor Flk-1 is involved in c-kit up regulation via ERK-mediated pathway.
Bai
Xiaowen
X
Department of Molecular Pathology, University of Texas, MD Anderson Cancer Center, SCRB2, Box 951, 7435 Fannin Street, Houston, TX 77054, United States.
Sadat
Sanga
S
Gehmert
Sebastian
S
Alt
Eckhard
E
Song
Yao-Hua
YH
D000273:Adipose Tissue / Q000166:cytology* / Q000378:metabolism*; D015415:Biomarkers; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*
D015415:Biomarkers; D019009:Proto-Oncogene Proteins c-kit; D040301:Vascular Endothelial Growth Factor Receptor-2