Sanionins: anti-inflammatory and antibacterial agents with weak cytotoxicity from the Antarctic moss Sanionia georgico-uncinata.
Sanionins A (1) and B (2) were isolated from the moss Sanionia georgico-uncinata, collected on the Antarctic Livingston Island. The compounds 1 and 2 were purified by solvent extraction, silica gel column chromatography, and preparative HPLC, consecutively. The structures of the both compounds were elucidated by 1D and 2D NMR experiments and mass spectrometric investigations. These compounds showed activity against important Gram-positive pathogens, such as mycobacteria, multiresistant staphylococci, and vancomycin resistant enterococci. This activity is combined with antiinflammatoric activity and low cytotoxicity.
Ivanova
Veneta
V
The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria. venibiva@microbio.bas.bg
Kolarova
Mariana
M
Aleksieva
Krasja
K
Dornberger
Klaus-Juergen
KJ
Haertl
Albert
A
Moellmann
Ute
U
Dahse
Hans-Martin
HM
Chipev
Nesho
N
D000818:Animals; D000864:Antarctic Regions; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity*; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity*; D001632:Bibenzyls / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity*; D044002:Bryophyta / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D004847:Epithelial Cells / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D007739:L Cells; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy; D013058:Mass Spectrometry; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D001632:Bibenzyls; D012997:Solvents; C524950:sanionin A