Violation of distribution symmetry in statistical evaluation of absolute enantioselective synthesis.
Enantiomeric excesses obtained in absolute enantioselective synthesis by chiral autocatalysis (Soai-reaction) were statistically analyzed. Two sets of parallel experiments, which were performed under chemically different conditions, are available. One group contains 37, while the other contains 84 preparative results. The former group shows some interesting tendencies but does not give conclusive statistical results. The sample of 84 parallel experiments, providing 39 R- and 45 S-excesses have shown that these data represent two distinct, non-symmetric sets with different non-Gaussian distributions. Clear S preference was found.
Barabas
Béla
B
Department of Stochastics, University of Technology and Economics, Müegyetem rkp. 3(H), H-1111 Budapest, Hungary.
Caglioti
Luciano
L
Zucchi
Claudia
C
Maioli
Marco
M
Gal
Emese
E
Micskei
Károly
K
Pályi
Gyula
G
D002384:Catalysis; D008956:Models, Chemical; D015233:Models, Statistical; D013237:Stereoisomerism