[Treatment of intestinal failure in adults. II. Pharmacological treatment options].
For patients with severe intestinal failure caused by short-bowel syndrome, pharmacological treatment options are available that can reduce the period in which parenteral nutrition is required. Appropriate agents include acid inhibitors, bile-salt binders, inhibitors of motility and secretion, antibiotics and pre- and probiotics. A number of intestinotrophic factors have also been identified that are reported to enhance the functional adaptation of the intestine following surgery or illness. These include glutamine, growth hormone, and glucagon-like peptide 2 and its analogues. Absorption of certain agents is reduced when specific portions of the intestine are lacking. For example, fat-soluble cyclosporine is poorly resorbed in patients without an ileum.
Kristinsson
J
J
Universitair Medisch Centrum St Radboud, afd. Maag-, Darm- en Leverziekten, Postbus 9101, 6500 HB Nijmegen.
Dijkstra
G
G
Wanten
G
G
D005769:Gastrointestinal Motility / Q000187:drug effects* / Q000502:physiology; D005973:Glutamine / Q000627:therapeutic use; D013006:Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects* / Q000502:physiology; D007410:Intestinal Diseases / Q000188:drug therapy*; D009747:Nutritional Physiological Phenomena; D019936:Probiotics; D012778:Short Bowel Syndrome / Q000188:drug therapy*
D005973:Glutamine; D013006:Growth Hormone