Antibodies to 46-kDa retinal antigen in a patient with breast carcinoma and cancer-associated retinopathy.
Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome usually associated with small-cell lung carcinoma and serum autoantibodies against recovering. We report the breast cancer woman with visual impairments and electrophysiological abnormalities characteristic of CAR. Her serum contained high-titer antibodies against alpha-enolase but not against other retinal proteins. This suggests that anti-enolase antibodies could be responsible for the development of CAR symptoms.
Ejma
Maria
M
Department of Neurology, Wrocław Medical University, Wrocław, Poland. mejma@interia.pl
Misiuk-Hojło
Marta
M
Gorczyca
Wojciech A
WA
Podemski
Ryszard
R
Szymaniec
Stanisław
S
Kuropatwa
Marianna
M
Rogozińska-Szczepka
Jadwiga
J
Bartnik
Wiesława
W
D001943:Breast Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D002277:Carcinoma / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D045744:Cell Line, Tumor; D004594:Electrophysiology / Q000379:methods; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D012160:Retina / Q000378:metabolism*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology*; D055752:Small Cell Lung Carcinoma / Q000150:complications / Q000473:pathology; D014785:Vision, Ocular
D010751:Phosphopyruvate Hydratase