title: The number of dopaminergic cells is increased in the olfactory bulb of monkeys chronically exposed to MPTP.
abstract: We investigated the impact of the nigrostriatal lesion on the olfactory tyrosine hydroxylase-immunoreactive (TH-ir) cells in monkeys. The majority of these TH-ir cells appeared in the glomerular layer of the olfactory bulb and many were immature but functional dopaminergic neurons. In parkinsonian monkeys the number of olfactory dopaminergic neurons increased up to 100% as compared to controls, but their phenotype did not change. This increased TH-ir cell population might be a direct consequence of the nigral cell loss and contribute to the hyposmia reported by Parkinson's disease patients.
authors.affiliation: Laboratory of Regenerative Therapy, Department of Neuroscience, Center for Applied Medicine Research, University of Navarra, Avenida Pío XII 55, 31008. Pamplona, Navarra, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Belzunegui
authors.forename: Waldy
authors.initials: W
authors.lastname: San Sebastián
authors.forename: Pablo
authors.initials: P
authors.lastname: Garrido-Gil
authors.forename: Amaya
authors.initials: A
authors.lastname: Izal-Azcárate
authors.forename: Marianne
authors.initials: M
authors.lastname: Vázquez-Claverie
authors.forename: Berta
authors.initials: B
authors.lastname: López
authors.forename: Irene
authors.initials: I
authors.lastname: Marcilla
authors.forename: José Luis
authors.initials: JL
authors.lastname: Lanciego
authors.forename: Maria Rosario
authors.initials: MR
authors.lastname: Luquin
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage*; D000818:Animals; D002452:Cell Count / Q000379:methods; D004298:Dopamine / Q000378:metabolism*; D015259:Dopamine Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D008252:Macaca fascicularis; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009830:Olfactory Bulb / Q000166:cytology* / Q000187:drug effects; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D015259:Dopamine Agents; D009419:Nerve Tissue Proteins; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine