title: [Sinonasal mucosal melanoma].
abstract: Mucosal melanomas of the nasal cavity and paranasal sinuses are rare and agresive neoplasms and carries a bad prognosis. The diagnosis may require confirmatory immunohistochemical stains (S-100 protein, HMB-45, vimentin and cytokeratine). The clinical records of 6 patients with the diagnosis of sinonasal melanomas between 1991 and 2005 were retrospectively reviewed. The mean age was 70 years (range 51 to 83 years), there were 2 men and 4 women. Surgery was performed in four patients, adjuvant radiation therapy was used in one patient after local recurrence and chemotherapy in three patients. Three of four patients (75%) had a recurrence after previous treatment (surgery). The actuarial disease-free survival for this group of 6 is 33.3% (2 of 6). Mucosal melanoma of the head and neck remains a difficult disease to treat, with high locoregional recurrence rates and poor prognosis.
authors.affiliation: Servicio de ORL, Hospital de eL Bierzo, Ponferrada, León. pilipomar@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: Pomar Blanco
authors.forename: J
authors.initials: J
authors.lastname: San Román Carbajo
authors.forename: M
authors.initials: M
authors.lastname: Bouso Montero
authors.forename: C
authors.initials: C
authors.lastname: Martín Villares
authors.forename: M
authors.initials: M
authors.lastname: Fernández Pello
authors.forename: M
authors.initials: M
authors.lastname: Tapia Risueño
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005005:Ethmoid Sinus / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy; D008545:Melanoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology; D009297:Nasal Mucosa / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D009669:Nose Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy; D049268:Positron-Emission Tomography; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed