title: Can magnetocardiography detect patients with non-ST-segment elevation myocardial infarction?
abstract: OBJECTIVE
  Magnetocardiography (MCG) has been proposed as a noninvasive diagnostic tool to risk-stratify patients with myocardial infarction (MI) and ischemia. The purpose of this study is to find the MCG parameters that are sensitive enough to detect the non-ST-segment elevation myocardial infarction (NSTEMI) patients.
  
  
  METHODS
  MCG data were recorded and analyzed from 165 young controls (mean age = 27.2 +/- 9.0 years), 57 age-matched controls (mean age = 55.9 +/- 10.5 years) and 83 NSTEMI patients (mean age = 59.7 +/- 11.1 years). The MCG recordings were obtained using a 64-channel MCG system in a magnetically shielded room. Statistical analyses were performed for 24 parameters derived from QRS-, R-, T-wave, and ST-T period. Binary boundaries to detect NSTEMI patients out of control subjects were found using the receiver operating characteristic (ROC) curve for each parameter.
  
  
  RESULTS
  Fifteen parameters showed a significant difference (P < 0.05 and P < 0.01) between NSTEMI and both of the control groups. For detection of NSTEMI, the angle of the maximum current and the filed map angle on T-wave peak showed the highest diagnostic performance from 75% to 92% including accuracy, sensitivity, specificity, positive predictive value, and negative predictive value (area under ROC curve = 0.87 approximately 0.93).
  
  
  CONCLUSIONS
  Our study showed that MCG has potential clinical application for detection of NSTEMI and should be further investigated.
authors.affiliation: Korea Research Institute of Standards and Science, Daejeon, Korea.
authors.forename: Hyun Kyoon
authors.initials: HK
authors.lastname: Lim
authors.forename: Namsik
authors.initials: N
authors.lastname: Chung
authors.forename: Kiwoong
authors.initials: K
authors.lastname: Kim
authors.forename: Young-Guk
authors.initials: YG
authors.lastname: Ko
authors.forename: Hyukchan
authors.initials: H
authors.lastname: Kwon
authors.forename: Yong-Ho
authors.initials: YH
authors.lastname: Lee
authors.forename: Jin-Mok
authors.initials: JM
authors.lastname: Kim
authors.forename: Boyoung
authors.initials: B
authors.lastname: Joung
authors.forename: Jin-Bae
authors.initials: JB
authors.lastname: Kim
authors.forename: Kwon Kyu
authors.initials: KK
authors.lastname: Yu
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Cho
authors.forename: In-Seon
authors.initials: IS
authors.lastname: Kim
authors.forename: Yong Ki
authors.initials: YK
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D004562:Electrocardiography; D005260:Female; D006801:Humans; D053798:Magnetocardiography; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D012372:ROC Curve; D018570:Risk Assessment; D012680:Sensitivity and Specificity