Light adaptation in cone vision involves switching between receptor and post-receptor sites.
We see over an enormous range of mean light levels, greater than the range of output signals retinal neurons can produce. Even highlights and shadows within a single visual scene can differ approximately 10,000-fold in intensity-exceeding the range of distinct neural signals by a factor of approximately 100. The effectiveness of daylight vision under these conditions relies on at least two retinal mechanisms that adjust sensitivity in the approximately 200 ms intervals between saccades. One mechanism is in the cone photoreceptors (receptor adaptation) and the other is at a previously unknown location within the retinal circuitry that benefits from convergence of signals from multiple cones (post-receptor adaptation). Here we find that post-receptor adaptation occurs as signals are relayed from cone bipolar cells to ganglion cells. Furthermore, we find that the two adaptive mechanisms are essentially mutually exclusive: as light levels increase the main site of adaptation switches from the circuitry to the cones. These findings help explain how human cone vision encodes everyday scenes, and, more generally, how sensory systems handle the challenges posed by a diverse physical environment.
Dunn
Felice A
FA
Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195, USA.
Lankheet
Martin J
MJ
Rieke
Fred
F
D000221:Adaptation, Ocular / Q000502:physiology* / Q000528:radiation effects*; D000818:Animals; D006801:Humans; D008027:Light; D008252:Macaca fascicularis; D008254:Macaca nemestrina; D023421:Models, Animal; D048530:Papio anubis; D051245:Retinal Bipolar Cells / Q000378:metabolism / Q000528:radiation effects; D017949:Retinal Cone Photoreceptor Cells / Q000378:metabolism* / Q000528:radiation effects*; D012165:Retinal Ganglion Cells / Q000378:metabolism / Q000528:radiation effects; D014785:Vision, Ocular / Q000502:physiology* / Q000528:radiation effects*