title: Coronary artery motion and cardiac phases: dependency on heart rate -- implications for CT image reconstruction.
abstract: This study had institutional review board approval; written informed consent was obtained. The purpose was to prospectively determine the heart rate (HR) dependency of three-dimensional (3D) coronary artery motion by incorporating into analysis the durations of systole and diastole. Thirty patients (seven women, 23 men; mean age, 56.6 years +/- 12.7 [standard deviation]; HR: 45-100 beats per minute) underwent electrocardiographically gated 64-section computed tomographic (CT) coronary angiography to determine coronary motion velocities at bifurcation points. Significance of velocity differences (P < .05) was determined by using analysis of variance for repeated measures and Bonferroni post hoc tests. HR dependency was determined by using linear regression analysis. HR significantly affected 3D coronary motion (r = 0.47, P < .009) through nonproportional shortening of systole and diastole (r = -0.82, P < .001), leading to percentage reconstruction interval shifts of coronary velocity troughs and peaks (P < .01). Results suggest that image reconstruction algorithms at CT coronary angiography be adapted to the individual patient's HR.
authors.affiliation: Institute of Diagnostic Radiology and Cardiovascular Center, University Hospital Zurich, Raemistrasse 100, CH-8091, Zurich, Switzerland.
authors.forename: Lars
authors.initials: L
authors.lastname: Husmann
authors.forename: Sebastian
authors.initials: S
authors.lastname: Leschka
authors.forename: Lotus
authors.initials: L
authors.lastname: Desbiolles
authors.forename: Tiziano
authors.initials: T
authors.lastname: Schepis
authors.forename: Oliver
authors.initials: O
authors.lastname: Gaemperli
authors.forename: Burkhardt
authors.initials: B
authors.lastname: Seifert
authors.forename: Philippe
authors.initials: P
authors.lastname: Cattin
authors.forename: Thomas
authors.initials: T
authors.lastname: Frauenfelder
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Flohr
authors.forename: Borut
authors.initials: B
authors.lastname: Marincek
authors.forename: Philipp A
authors.initials: PA
authors.lastname: Kaufmann
authors.forename: Hatem
authors.initials: H
authors.lastname: Alkadhi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed / Q000379:methods*