title: [Seminal quality and hormones in patients with diabetes mellitus type 2].
abstract: BACKGROUND
  The role of the series of metabolic derangements associated to diabetes mellitus type 2 on the function of the hypothalamic-pituitary-testicular axis and on semen quality is still controversial due in part to the lack of information about the selection criteria of subjects included in previously published studies. This is important due to the high prevalence of occult pathology of the seminal tract.
  
  
  OBJECTIVE
  To determine if diabetes mellitus type 2 is related to hormonal or seminal disorders.
  
  
  METHODS
  In this retrospective study serum concentration of the hormones that regulate the hypothalamic-pituitary-testicular axis and semen quality were analyzed comparatively in patients with diabetes mellitus type 2 and normoglycemic subjects. In both groups occult seminal disorders and conditions associated to the hypothalamic-pituitary-testicular axis dysfunction were discarded.
  
  
  RESULTS
  Serum concentration of FSH was higher in patients with diabetes mellitus type 2 than in controls (6.06 +/- 2.28 vs. 4.74 +/- 1.92, p = 0.04). Serum concentration of prolactin was lower in diabetics than in controls (6.71 +/- 1.28 vs. 8 +/- 1.97, p = 0.002). The only seminal abnormality found in patients with diabetes mellitus type 2 was a lower progressive mobility (46.52 +/- 17.77 vs. 58.88 +/- 16.81, p = 0.003).
  
  
  CONCLUSIONS
  This suggests that the patients with diabetes mellitus type 2 have subclinical tubular dysfunction manifested by a low sperm progressive mobility and that this might be associated to subfertility.
authors.affiliation: Clinica de Andrologia, Instituto Nacional de Perinatologia, México.
authors.forename: Mirna G
authors.initials: MG
authors.lastname: Echavarría Sánchez
authors.forename: Erika
authors.initials: E
authors.lastname: Franco Laguna
authors.forename: Armando
authors.initials: A
authors.lastname: Juárez Bengoa
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Villanueva Díaz
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012661:Semen; D013081:Sperm Motility
chemical_list: D006728:Hormones