Cellular angiofibroma is genetically similar to spindle cell lipoma: a case report.
Cellular angiofibroma is a benign mesenchymal neoplasm of female and male genital tract composed of prominent vasculature and stromal spindle cells, often with admixture of adipose tissue. The tumor has histomorphologic similarities to angiomyofibroblastoma and spindle cell lipoma. Herein we describe a tumor arising in the perineal region of a 60-year-old man with morphological and immunohistochemical features of cellular angiofibroma and showing cytogenetic characteristics similar to spindle cell lipoma. To our knowledge, this is the first report of cytogenetic changes in cellular angiofibroma. The genetic overlap of these entities supports their origin from the same mesenchymal stem cell.
Hameed
Meera
M
Department of Pathology, University of Medicine and Dentistry of New Jersey--New Jersey Medical School, 150 Bergen Street, UHE-141, Newark, NJ 07103, USA. hameedmr@umdnj.edu
Clarke
Kevin
K
Amer
Hoda Zeinab
HZ
Mahmet
Kathleen
K
Aisner
Seena
S
D018322:Angiofibroma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008067:Lipoma / Q000378:metabolism / Q000473:pathology*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D018331:Nevus, Spindle Cell / Q000378:metabolism / Q000473:pathology*