title: The effect of recurrent tonsillitis and adenotonsillectomy on growth in childhood.
abstract: OBJECTIVE
  Tonsil and adenoid hypertrophy may cause recurrent tonsillitis and upper airway obstruction in children. A reduced dietary intake and failure to gain weight is frequently reported by parents of children with a history of recurrent acute tonsillitis and adenotonsiller hypertrophy. The purpose of this prospective study was to evaluate whether surgical treatment of adenotonsillar hypertrophy affects the circulating concentrations of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 3 (IGFBP-3) along with IGF-1 SDS and IGFBP-3 SDS's adjusted to age which are more important in evaluating growth in childhood.
  
  
  METHODS
  Thirty-eight prepubertal children 24 boys and 14 girls participated in this study. The mean age at surgery was 6.66+/-1.84 years (range 4-10 years). Weight, height, IGF-1 and IGFBP-3 levels and standard deviation scores were evaluated before and 12-18 months after adenotonsillectomy (T&A).
  
  
  RESULTS
  The number of infections in a year reduced from 8.6+/-4.4 to 0.37+/-0.68 after operation. The mean weight standard deviation score (SDS) increased significantly after T&A (p<0.01). The mean IGFBP-3 level increased from 1912+/-511.5 to 2989+/-1125ng/ml (p<0.001) and IGFBP-3 SDS increased from -3.0+/-0.58 SDS to -1.96+/-1.27 SDS (p: 0.001). However, the mean serum IGF-1 level increased from 80.3+/-48.5 to 116.8+/-105.9ng/ml (p: 0.135), and IGF-1 SDS increased from -1.36+/-0.51 SDS to -1.31+/-1.14 SDS (p: 0.701), which were both not statistically significant.
  
  
  CONCLUSIONS
  We have demonstrated postoperative weight gain and significant increase in IGFBP-3 concentrations and IGFBP-3 SDS, accompanying significant decrease in the number of tonsillitis episodes after adenotonsillectomy.
authors.affiliation: Department of Pediatrics, Kocaeli University, School of Medicine, Kocaeli, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Aydogan
authors.forename: Demet
authors.initials: D
authors.lastname: Toprak
authors.forename: Sükrü
authors.initials: S
authors.lastname: Hatun
authors.forename: Atilla
authors.initials: A
authors.lastname: Yüksel
authors.forename: Ayse Sevim
authors.initials: AS
authors.lastname: Gokalp
mesh_terms: D000233:Adenoidectomy / Q000706:statistics & numerical data*; D000234:Adenoids / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006984:Hypertrophy / Q000473:pathology / Q000601:surgery; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D011184:Postoperative Period; D015995:Prevalence; D012008:Recurrence; D012891:Sleep Apnea Syndromes / Q000453:epidemiology; D014068:Tonsillectomy / Q000706:statistics & numerical data*; D014069:Tonsillitis / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery*
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone