Consumption of sericin suppresses colon oxidative stress and aberrant crypt foci in 1,2-dimethylhydrazine-treated rats by colon undigested sericin.
This study was conducted to examine the mechanisms of the anti-colon tumor effect of dietary sericin. Dietary supplementation of 3% sericin reduced colon mucosal lipid peroxide and aberrant crypt foci in 1,2-dimethylhydrazine-treated rats. The colon content from sericin-fed rats had much stronger antioxidant activity compared to that from control rats not receiving sericin. The amino acid composition of undigested proteins in the colon contents from sericin-fed rats was similar to that of sericin ingested. The results suggest that the strong antioxidant activity of undigested sericin in the colon content causes lower oxidative stress and tumorigenesis in the colon.
Zhaorigetu
Siquin
S
Graduate School of Biosphere Science, Hiroshima University, Kagamiyama 1-4-4, Higashi-Hiroshima 739-8528, Japan.
Sasaki
Masahiro
M
Kato
Norihisa
N
D019813:1,2-Dimethylhydrazine; D000284:Administration, Oral; D000596:Amino Acids / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D002273:Carcinogens; D002364:Caseins / Q000008:administration & dosage / Q000494:pharmacology; D003106:Colon / Q000187:drug effects* / Q000473:pathology; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D019587:Dietary Supplements; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D047030:Sericins / Q000008:administration & dosage*; D017392:Thiobarbituric Acid Reactive Substances
D000596:Amino Acids; D000975:Antioxidants; D002273:Carcinogens; D002364:Caseins; D047030:Sericins; D017392:Thiobarbituric Acid Reactive Substances; D019813:1,2-Dimethylhydrazine