title: Autograft regurgitation and aortic root dimensions after the Ross procedure: the German Ross Registry experience.
abstract: BACKGROUND
  Autograft regurgitation and root dilatation after the Ross procedure is of major concern. We reviewed data from the German Ross Registry to document the development of autograft regurgitation and root dilatation with time and also to compare 2 different techniques of autograft implantation.
  
  
  RESULTS
  Between 1990 and 2006 1014 patients (786 men, 228 women; mean age 41.2+/-15.3 years) underwent the Ross procedure using 2 different implantation techniques (subcoronary, n=521; root replacement, n=493). Clinical and serial echocardiographic follow up was performed preoperatively and thereafter annually (mean follow up 4.41+/-3.11 years, median 3.93 years, range 0 to 16.04 years; 5012 patient-years). For statistical analysis of serial echocardiograms, a hierarchical multilevel modeling technique was applied. Eight early and 28 late deaths were observed. Pulmonary autograft reoperations were required in 35 patients. Initial autograft regurgitation grade was 0.49 (root replacement 0.73, subcoronary 0.38) with an annual increase of grade 0.034 (root replacement 0.0259, subcoronary 0.0231). Annulus and sinus dimensions did not exhibit an essential increase over time in both techniques, whereas sinotubular junction diameter increased essentially by 0.5 mm per year in patients with root replacement. Patients with the subcoronary implantation technique showed nearly unchanged dimensions. Bicuspid aortic valve morphology did not have any consistent impact on root dimensions with time irrespective of the performed surgical technique.
  
  
  CONCLUSIONS
  The present Ross series from the German Ross Registry showed favorable clinical and hemodynamic results. Development of autograft regurgitation for both techniques was small and the annual progression thereof is currently not substantial. Use of the subcoronary technique and aortic root interventions with stabilizing measures in root replacement patients seem to prevent autograft regurgitation and dilatation of the aortic root within the timeframe studied.
authors.affiliation: Department of Cardiac and Thoracic Vascular Surgery, University of Luebeck, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Hanke
authors.forename: Ulrich
authors.initials: U
authors.lastname: Stierle
authors.forename: Juergen O
authors.initials: JO
authors.lastname: Boehm
authors.forename: Cornelius A
authors.initials: CA
authors.lastname: Botha
authors.forename: J F
authors.initials: JF
authors.lastname: Matthias Bechtel
authors.forename: Armin
authors.initials: A
authors.lastname: Erasmi
authors.forename: Martin
authors.initials: M
authors.lastname: Misfeld
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hemmer
authors.forename: Joachim G
authors.initials: JG
authors.lastname: Rein
authors.forename: Derek R
authors.initials: DR
authors.lastname: Robinson
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Lange
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hörer
authors.forename: Anton
authors.initials: A
authors.lastname: Moritz
authors.forename: Feyzan
authors.initials: F
authors.lastname: Ozaslan
authors.forename: Thorsten
authors.initials: T
authors.lastname: Wahlers
authors.forename: Ulrich F W
authors.initials: UF
authors.lastname: Franke
authors.forename: Roland
authors.initials: R
authors.lastname: Hetzer
authors.forename: Michael
authors.initials: M
authors.lastname: Hübler
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ziemer
authors.forename: Bernhard
authors.initials: B
authors.lastname: Graf
authors.forename: Donald N
authors.initials: DN
authors.lastname: Ross
authors.forename: Hans H
authors.initials: HH
authors.lastname: Sievers
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000637:transplantation*; D001022:Aortic Valve Insufficiency / Q000453:epidemiology* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries; D014182:Transplantation, Autologous