Triethylene tetramine, a novel ligand of G-quadruplex, induces senescence of MCF-7 cells.
Interference with telomerase and telomere maintenance is emerging as an attractive target for antitumor therapies. Ligands stabilizing G-quadruplexes have the potential to interfere with telomere replication by blocking the elongation of telomeres in tumors. Here, we report that long-term treatment with triethylene tetramine (TETA), at 50 or 100 microM, induced marked cellular senescence phenotypes accompanied by increased time of population doubling of MCF-7 cells. Cyclin-dependent kinase inhibitors, including p53 and p21, were also upregulated in TETA-treated MCF-7 cells. TETA is therefore as novel ligand of G-quadruplex and can induce tumor senescence; it is a promising material for tumor treatment.
Lixia
Guo
G
Research Center of Pharmaceutical Chemistry & Chemobiology, Chongqing Technology and Business University, Chongqing 400067, China.
Fei
Yin
Y
Jiajia
Jing
J
Jianhui
Liu
L
D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D016922:Cellular Senescence / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D014266:Trientine / Q000008:administration & dosage*
D008024:Ligands; D014266:Trientine