Isatinones A and B, new antifungal oxindole alkaloids from Isatis costata.
Two new oxindole alkaloids isatinone A (1) and B (2) have been isolated from Isatis costata, along with the known trisindoline. Their structures have been assigned on the basis of spectroscopic techniques and chemical studies. Both new compounds showed significant antifungal activity.
Fatima
Itrat
I
International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Ahmad
Ijaz
I
Anis
Itrat
I
Malik
Abdul
A
Afza
Nighat
N
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D031219:Isatis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D000078183:Oxindoles; D010648:Phenylacetates / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*
C523692:2-ethylhexyl 2-(4-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)(phenyl)methoxy)phenylacetate; C523691:3-(methoxy(phenyl)methylidene)-1,3-dihydro-2H-indol-2-one; D000470:Alkaloids; D000935:Antifungal Agents; D007211:Indoles; D000078183:Oxindoles; D010648:Phenylacetates; D010936:Plant Extracts; C022960:2-oxindole