title: Predictors of the evolution towards schizophrenia or mood disorder in patients with schizophreniform disorder.
abstract: In this study, 56 patients affected by schizophreniform disorder (SFD), as their first lifetime mental disorder, were re-evaluated 7.9+/-4.7 yrs (2-17 yrs) after their first hospitalization. At follow-up, schizophrenia (SC) was diagnosed in 25 patients (46%), a mood disorder (MD) in 19 (35%), a non-SC psychotic disorder in 10 (18%) and no disorder in 2 (4%). The evolution towards SC was predicted by the presence of blunted affect (OR: 1.88) and by poor pre-morbid functioning (OR: 1.10) at the index hospitalization. Our data suggest that SFD may represent the first psychotic presentation of different disorders and the evolution towards SC or a MD seems to be influenced by the pre-morbid level of functioning and by the presence of blunted affect.
authors.affiliation: Psychiatric Section, Department of Neuroscience, University of Parma, Parma, Italy. carlo.marchesi@unipr.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Marchesi
authors.forename: Matteo
authors.initials: M
authors.lastname: Paini
authors.forename: Luca
authors.initials: L
authors.lastname: Ruju
authors.forename: Luca
authors.initials: L
authors.lastname: Rosi
authors.forename: Giuliano
authors.initials: G
authors.lastname: Turrini
authors.forename: Carlo
authors.initials: C
authors.lastname: Maggini
mesh_terms: D000293:Adolescent; D000328:Adult; D000342:Affective Symptoms / Q000175:diagnosis / Q000523:psychology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000523:psychology; D010054:Brief Psychiatric Rating Scale; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000523:psychology; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012917:Social Adjustment