Mefloquine versus 3-day oral quinine-clindamycin in uncomplicated imported falciparum malaria.
In this open randomized trial comparing 3-day oral quinine-clindamycin versus standard mefloquine regimen for uncomplicated imported falciparum malaria, mefloquine treatment was associated with a higher risk of discontinuation of the treatment (RR=1.8, 95% CI [1.1-2.8]) related to mainly mild gastrointestinal adverse drug events. The poor tolerability of mefloquine sets a question mark against its use in outpatients.
Ranque
Stéphane
S
Laboratoire de Parasitologie et Mycologie, IFR 48, Faculté de Médecine, 27 Bd. Jean Moulin, 13385 Marseille Cedex 5, France. stephane.ranque@ap-hm.fr
Parola
Philippe
P
Adehossi
Eric
E
Brouqui
Philippe
P
Delmont
Jean
J
D000284:Administration, Oral; D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D002981:Clindamycin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D015767:Mefloquine / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D011803:Quinine / Q000008:administration & dosage*; D014195:Travel
D000962:Antimalarials; D002981:Clindamycin; D011803:Quinine; D015767:Mefloquine