Are new agents used to treat rheumatoid arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study.
OBJECTIVE
I have a patient planning pregnancy who has resistant rheumatoid arthritis that will require treatment with some of the "new" medications. Which ones are safe to use during pregnancy, and which ones do we know enough about to tell whether they are safe or not?


CONCLUSIONS
For most new disease-modifying biologic medications, we have few data on safety. More and more reassuring data are accumulating on azathioprine and cyclosporine. When you treat this patient, you can help in gathering such data by contacting the Organization of Teratology Information Specialists' Autoimmune Disease in Pregnancy study through Motherisk at 877 311-8972.
Chambers
Christina
C
Koren
Gideon
G
Tutuncu
Zuhre N
ZN
Johnson
Diana
D
Jones
Kenneth L
KL
D000014:Abnormalities, Drug-Induced / Q000175:diagnosis* / Q000453:epidemiology; D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy; D001379:Azathioprine / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D015994:Incidence; D007255:Information Services; D007555:Isoxazoles / Q000008:administration & dosage / Q000009:adverse effects; D000077339:Leflunomide; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D018570:Risk Assessment; D012460:Sulfasalazine / Q000008:administration & dosage / Q000009:adverse effects; D013723:Teratogens
D000962:Antimalarials; D018501:Antirheumatic Agents; D007555:Isoxazoles; D013723:Teratogens; D012460:Sulfasalazine; D000077339:Leflunomide; D001379:Azathioprine