title: Effect of autologous blood transfusion on the rate of biochemical recurrence after radical prostatectomy.
abstract: OBJECTIVE
  To test the association between autologous blood transfusion (ABT) and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large group of contemporary patients.
  
  
  METHODS
  We analysed 1291 patients treated with RP; Kaplan-Meier analysis was used to graphically explore the association between ABT and BCR. Cox regression models addressed the association between ABT and BCR in univariate and multivariate analyses, after adjusting for preoperative prostate specific antigen level, pathological Gleason sum, extracapsular extension, seminal vesicle invasion and lymph node invasion.
  
  
  RESULTS
  Of all patients, 205 (15.4%) received perioperative ABT. The mean (median, range) follow-up was 43.2 (40.9, 0.3-145) months. BCR was recorded in 347 (26.9%) patients and the time to BCR was 25.2 (20.5, 0.3-107) months. Neither in univariate (P = 0.053) nor in multivariate (P = 0.2) Cox regression analyses was ABT a statistically significant or independent predictor of BCR.
  
  
  CONCLUSIONS
  Perioperative ABT does not predispose to a higher rate of BCR in patients after RP.
authors.affiliation: Department of Urology, Vita-Salute University San Raffaele, Milan, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Gallina
authors.forename: Alberto
authors.initials: A
authors.lastname: Briganti
authors.forename: Felix K-H
authors.initials: FK
authors.lastname: Chun
authors.forename: Jochen
authors.initials: J
authors.lastname: Walz
authors.forename: Georg C
authors.initials: GC
authors.lastname: Hutterer
authors.forename: Andreas
authors.initials: A
authors.lastname: Erbersdobler
authors.forename: Christian
authors.initials: C
authors.lastname: Eichelberg
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schlomm
authors.forename: Sascha A
authors.initials: SA
authors.lastname: Ahyai
authors.forename: Paul
authors.initials: P
authors.lastname: Perrotte
authors.forename: Fred
authors.initials: F
authors.lastname: Saad
authors.forename: Francesco
authors.initials: F
authors.lastname: Montorsi
authors.forename: Hartwig
authors.initials: H
authors.lastname: Huland
authors.forename: Markus
authors.initials: M
authors.lastname: Graefen
authors.forename: Pierre I
authors.initials: PI
authors.lastname: Karakiewicz
mesh_terms: D000328:Adult; D000368:Aged; D016063:Blood Loss, Surgical; D001804:Blood Transfusion, Autologous / Q000009:adverse effects*; D004812:Epidemiologic Methods; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000209:etiology* / Q000473:pathology; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen