title: [Evaluation of pregnancy-associated plasma protein A (PAPP-A) and free beta subunit of human chorionic gonadotropin (beta hCG) levels and sonographic assesement of fetal nuchal translucency (NT) in singleton pregnancies between 11 and 14 weeks of gestation--Polish multi-centre research].
abstract: Evaluation of pregnancy-associated plasma protein A (PAPP-A) and free beta subunit of human chorionic gonadotropin (beta hCG) levels and sonographic assessment of fetal nuchal translucency (NT) in singleton pregnancies between 11 and 14 weeks of gestation--Poland's multi-centers research.
  
  
  OBJECTIVE
  Pregnancy-associated plasma protein A has been reported to be low in Down syndrome affected pregnancies during the first trimester of pregnancy. Enlarged nuchal translucency (NT) is observed in about 80% of fetuses affected with chromosomal abnormalities and congenital heart defects (CHD).
  
  
  METHODS
  The aim of this study were to determine value and the medians of free beta-human chorionic gonadotropin (beta-hCG) and pregnancy associated plasma protein-A (PAPP-A) and nuchal translucency thickness in the first trimester in a prospective study of a non-selected Polish population.
  
  
  RESULTS
  All examinations have been performed according to the Fetal Medicine Foundation (FMF) rules. We have included 800 women between 11 weeks 0 days and 13 weeks 6 days gestation into a biochemical examination. Women booked into the clinic were offered screening, using a combination of maternal serum free beta-hCG and pregnancy-associated plasma protein-A (PAPP-A) and fetal nuchal translucency thickness. The maternal serum were measured using the Kryptor analyzer (Brahms Diagnostica). All pregnant women have been divided into 2 groups younger than (first group) and older than (second group) 35 years of age.
  
  
  CONCLUSIONS
  Nomogrames for free beta-hCG and PAPP-A levels in physiological pregnancy between 11(+0) and 13(6) weeks were determined in the examined population. A positive correlation between PAPP-A and CRL levels, as well as a weak negative correlation between free beta-hCG and CRL, were demonstrated.
authors.affiliation: Klinika Terapii Płodu ICZMP w łodzi. boromed@o2.pl
authors.forename: Dariusz
authors.initials: D
authors.lastname: Borowski
authors.forename: Bartosz
authors.initials: B
authors.lastname: Czuba
authors.forename: Wojciech
authors.initials: W
authors.lastname: Cnota
authors.forename: Piotr
authors.initials: P
authors.lastname: Hincz
authors.forename: Artur
authors.initials: A
authors.lastname: Czekierdowski
authors.forename: Joanna
authors.initials: J
authors.lastname: Gajewska
authors.forename: Renata
authors.initials: R
authors.lastname: Jaczyńska
authors.forename: Alicja
authors.initials: A
authors.lastname: Ceran
authors.forename: Agata
authors.initials: A
authors.lastname: Włoch
authors.forename: Dorota
authors.initials: D
authors.lastname: Wyrwas
authors.forename: Mirosław
authors.initials: M
authors.lastname: Wiełgoś
authors.forename: Iwona
authors.initials: I
authors.lastname: Szymusik
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szaflik
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Sodowski
mesh_terms: D000328:Adult; D000367:Age Factors; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D004314:Down Syndrome / Q000175:diagnosis*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D048208:Nuchal Translucency Measurement; D011044:Poland; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis; D011261:Pregnancy Trimester, First; D018566:Pregnancy, High-Risk; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D011296:Prenatal Diagnosis / Q000379:methods; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A