title: Isatinones A and B, new antifungal oxindole alkaloids from Isatis costata.
abstract: Two new oxindole alkaloids isatinone A (1) and B (2) have been isolated from Isatis costata, along with the known trisindoline. Their structures have been assigned on the basis of spectroscopic techniques and chemical studies. Both new compounds showed significant antifungal activity.
authors.affiliation: International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Itrat
authors.initials: I
authors.lastname: Fatima
authors.forename: Ijaz
authors.initials: I
authors.lastname: Ahmad
authors.forename: Itrat
authors.initials: I
authors.lastname: Anis
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Nighat
authors.initials: N
authors.lastname: Afza
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D031219:Isatis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D000078183:Oxindoles; D010648:Phenylacetates / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: C523692:2-ethylhexyl 2-(4-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)(phenyl)methoxy)phenylacetate; C523691:3-(methoxy(phenyl)methylidene)-1,3-dihydro-2H-indol-2-one; D000470:Alkaloids; D000935:Antifungal Agents; D007211:Indoles; D000078183:Oxindoles; D010648:Phenylacetates; D010936:Plant Extracts; C022960:2-oxindole