N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors.
Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.
Rakowitz
D
D
Institute of Pharmacy, Leopold-Franzens University of Innsbruck, Austria.
Gmeiner
A
A
Matuszczak
B
B
D000085:Acetates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002417:Cattle; D004121:Dimethyl Sulfoxide; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization
D000085:Acetates; D004791:Enzyme Inhibitors; D011799:Quinazolines; D012997:Solvents; D000449:Aldehyde Reductase; D004121:Dimethyl Sulfoxide