title: Combined double lung-liver transplantation for cystic fibrosis without cardio-pulmonary by-pass.
abstract: Sequential bilateral single lung-liver transplantation (SBSL-LTx) is a therapeutic option for patients with end stage lung and liver disease (ESLLD) due to cystic fibrosis (CF). A few cases have been reported, all of them were performed with the use of cardio-pulmonary by-pass (CPB). We performed SBSL-LTx in three young men affected by CF. All the recipients had respiratory failure and portal hypertension with hypersplenism. Along with lung transplants, two patients received a whole liver graft and one an extended right graft from an in situ split liver. During transplantation neither CPB nor veno-venous by-pass (VVB) were employed. Immunosuppression was based on basiliximab, tacrolimus, steroids and azathioprine. The three recipients are alive with a median follow-up of 670 days (range 244-1,533). Combined SBSL-LTx is a complex but effective procedure for the treatment of ESLLD due to CF, not necessarily requiring the use of CPB or VVB.
authors.affiliation: General Surgery III Liver and Lung Transplantation Center, Ospedali Riuniti, Bergamo, Italy. vcorno@ospedaliriuniti.bergamo.it
authors.forename: V
authors.initials: V
authors.lastname: Corno
authors.forename: M C
authors.initials: MC
authors.lastname: Dezza
authors.forename: A
authors.initials: A
authors.lastname: Lucianetti
authors.forename: D
authors.initials: D
authors.lastname: Codazzi
authors.forename: B
authors.initials: B
authors.lastname: Carrara
authors.forename: D
authors.initials: D
authors.lastname: Pinelli
authors.forename: P C
authors.initials: PC
authors.lastname: Parigi
authors.forename: M
authors.initials: M
authors.lastname: Guizzetti
authors.forename: M
authors.initials: M
authors.lastname: Strazzabosco
authors.forename: M L
authors.initials: ML
authors.lastname: Melzi
authors.forename: G
authors.initials: G
authors.lastname: Gaffuri
authors.forename: V
authors.initials: V
authors.lastname: Sonzogni
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: S
authors.initials: S
authors.lastname: Fagiuoli
authors.forename: M
authors.initials: M
authors.lastname: Colledan
mesh_terms: D000328:Adult; D002315:Cardiopulmonary Bypass; D003550:Cystic Fibrosis / Q000150:complications* / Q000601:surgery*; D006801:Humans; D007432:Intraoperative Period; D017093:Liver Failure / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D008171:Lung Diseases / Q000209:etiology / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D016896:Treatment Outcome