title: Childhood pustular psoriasis associated with Panton-Valentine leukocidin-producing Staphylococcus aureus.
abstract: We report the association of a generalized pustular psoriasis and infection by Staphylococcus aureus which produced Panton-Valentine leukocidin in a 5-year-old child. Another S. aureus strain with the same toxin gene content was also isolated among three family members presenting with cutaneous lesions. Although a methicillin-resistant staphylococcal strain has been reported in association with pustular psoriasis, this is the first report of a Panton-Valentine leukocidin strain associated with generalized pustular psoriasis. The causal relationship between S. aureus produced Panton-Valentine leukocidin and skin lesions is discussed.
authors.affiliation: Department of Paediatrics, Victor Provo Hospital, Roubaix, France. guillaume.pouessel@ch-roubaix.fr
authors.forename: Guillaume
authors.initials: G
authors.lastname: Pouessel
authors.forename: Hubert
authors.initials: H
authors.lastname: Ythier
authors.forename: Olivier
authors.initials: O
authors.lastname: Carpentier
authors.forename: Anne
authors.initials: A
authors.lastname: Vachée
authors.forename: Jerome
authors.initials: J
authors.lastname: Etienne
authors.forename: Benoit
authors.initials: B
authors.lastname: Catteau
mesh_terms: D001427:Bacterial Toxins; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000382:microbiology; D005098:Exotoxins; D005260:Female; D006801:Humans; D007956:Leukocidins; D016106:Methicillin Resistance; D011565:Psoriasis / Q000382:microbiology*; D013207:Staphylococcal Skin Infections / Q000150:complications*; D013211:Staphylococcus aureus / Q000302:isolation & purification*
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin