title: Maternal hyperandrogenism beginning from early pregnancy and progressing until delivery does not produce virilization of a female newborn.
abstract: A 33-year-old primagravida with a history of polycystic ovary syndrome was referred because of symptoms of moderate hyperandrogenism. Serum hormone levels, measured regularly from the 7th week of pregnancy until delivery, showed very high increases of testosterone, androstenedione and estradiol. Ultrasound showed no evidence of adrenal or ovarian masses. She delivered a female newborn with normal female external genitalia. Umbilical cord hormone levels were normal, except for a modest increase of serum testosterone. After delivery the androgen levels of the mother returned to normal and the symptoms of hyperandrogenism were also slightly improved.
authors.affiliation: Second Department of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Rita
authors.initials: R
authors.lastname: Bertalan
authors.forename: Laszlo
authors.initials: L
authors.lastname: Csabay
authors.forename: Anna
authors.initials: A
authors.lastname: Blazovics
authors.forename: Janos
authors.initials: J
authors.lastname: Rigo
authors.forename: Ibolya
authors.initials: I
authors.lastname: Varga
authors.forename: Zita
authors.initials: Z
authors.lastname: Halasz
authors.forename: Erzsebet
authors.initials: E
authors.lastname: Toldy
authors.forename: Belema
authors.initials: B
authors.lastname: Boyle
authors.forename: Karoly
authors.initials: K
authors.lastname: Racz
mesh_terms: D000328:Adult; D000735:Androstenedione / Q000378:metabolism; D001141:Aromatase / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism; D005260:Female; D047109:Fetal Development / Q000502:physiology; D006628:Hirsutism / Q000150:complications; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications* / Q000473:pathology; D007231:Infant, Newborn; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D011248:Pregnancy Complications; D013739:Testosterone / Q000378:metabolism*
chemical_list: D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol; D001141:Aromatase