The mechanism by which dietary AGEs are a risk to human health is via their interaction with RAGE: arguing against the motion.
We are interested in the regulation of intracellular calcium and the various diseases associated with an altered regulation of this second messenger. More recently, we also became interested in pathologies involving the Ca2+-binding S100 proteins and AGEs and their association with the multifunctional Receptor for Advanced Glycation Endproducts (RAGE).
Heizmann
Claus W
CW
Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Switzerland. Claus.Heizmann@kispi.unizh.ch
D002118:Calcium / Q000378:metabolism; D004032:Diet; D017127:Glycation End Products, Advanced / Q000009:adverse effects* / Q000494:pharmacology*; D006801:Humans; D015416:Maillard Reaction; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*; D009418:S100 Proteins / Q000378:metabolism
D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D009418:S100 Proteins; D002118:Calcium