Cognitive changes in the preclinical phase of familial Alzheimer's disease.
Few studies have examined the presence of linguistic deficits in the preclinical phase of Alzheimer's disease (AD). A total of 19 healthy carriers of the E280A presenilin-1 gene mutation in chromosome 14 and 21 noncarrier family members from Antioquia, Colombia, were administered a neurolinguistic evaluation of lexical-semantic processes. Both groups were similar in age, educational level, and gender. Carriers scored significantly lower than noncarriers on naming of famous faces. Cognitive changes in lexical-semantic tasks can be detected before the clinical diagnosis of probable familial AD, and a neurolinguistic evaluation may be a useful tool in the early clinical diagnosis of sporadic AD as well.
Arango-Lasprilla
Juan Carlos
JC
Neuroscience Group, University of Antioquia, Medellín, Colombia. jcarangolasp@vcu.edu
Cuetos
Fernando
F
Valencia
Claudia
C
Uribe
Claramonika
C
Lopera
Francisco
F
D000328:Adult; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010375:Pedigree; D053764:Presenilin-1 / Q000235:genetics*; D021641:Recognition, Psychology / Q000502:physiology*; D012016:Reference Values; D014705:Verbal Behavior / Q000502:physiology*
D053764:Presenilin-1