title: Cardenolides from Saussurea stella with cytotoxicity toward cancer cells.
abstract: Three new cardenolides, 3-O-beta-D-fucopyranosylstrophanthidin (1), 3-O-beta-D-quinovopyranosylperiplogenin (2), and 3-O-beta-D-glucopyranosyl-(1 --> 4)-alpha- l-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4- 10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2- 10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC 50 values of <1 microM for both cell lines. This is the first report of cardenolides occurring in a species of the family Asteraceae.
authors.affiliation: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
authors.forename: Tian-Min
authors.initials: TM
authors.lastname: Wang
authors.forename: Toshinari
authors.initials: T
authors.lastname: Hojo
authors.forename: Fu-Xiang
authors.initials: FX
authors.lastname: Ran
authors.forename: Ru-Feng
authors.initials: RF
authors.lastname: Wang
authors.forename: Rui-Qing
authors.initials: RQ
authors.lastname: Wang
authors.forename: Hu-Biao
authors.initials: HB
authors.lastname: Chen
authors.forename: Jing-Rong
authors.initials: JR
authors.lastname: Cui
authors.forename: Ming-Ying
authors.initials: MY
authors.lastname: Shang
authors.forename: Shao-Qing
authors.initials: SQ
authors.lastname: Cai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D030441:Saussurea / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D004365:Drugs, Chinese Herbal