title: The origin of trisomy 13.
abstract: Trisomy 13 is one of the most common trisomies in clinically recognized pregnancies and one of the few trisomies identified in liveborns, yet relatively little is known about the errors that lead to trisomy 13. Accordingly, we initiated studies to investigate the origin of the extra chromosome in 78 cases of trisomy 13. Our results indicate that the majority of cases (>91%) are maternal in origin and, similar to other autosomal trisomies, the extra chromosome is typically due to errors in meiosis I. Surprisingly, however, a large number of errors also occur during maternal meiosis II ( approximately 37%), distinguishing trisomy 13 from other acrocentric and most nonacrocentric chromosomes. As with other trisomies, failure to recombine is an important contributor to nondisjunction of chromosome 13.
authors.affiliation: Center for Reproductive Biology and School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4660, USA.
authors.forename: Heather E
authors.initials: HE
authors.lastname: Hall
authors.forename: E Ricky
authors.initials: ER
authors.lastname: Chan
authors.forename: Andrew
authors.initials: A
authors.lastname: Collins
authors.forename: LuAnn
authors.initials: L
authors.lastname: Judis
authors.forename: Sofia
authors.initials: S
authors.lastname: Shirley
authors.forename: Urvashi
authors.initials: U
authors.lastname: Surti
authors.forename: Lori
authors.initials: L
authors.lastname: Hoffner
authors.forename: Annette E
authors.initials: AE
authors.lastname: Cockwell
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Jacobs
authors.forename: Terry J
authors.initials: TJ
authors.lastname: Hassold
mesh_terms: D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D009630:Nondisjunction, Genetic; D011995:Recombination, Genetic; D014314:Trisomy