[Diabetes insipidus revealing chronic myelomonocytic leukemia].
BACKGROUND
Central diabetes insipidus is most frequently reported to occur after a trauma from surgery or accident. However, between 30 and 50% of cases are considered idiopathic. It's a rare complication of myelodysplastic syndrome.


METHODS
A 61-year-old patient presented central diabetes insipidus revealing, 17 months before, chronic myelomonocytic leukemia. Cytogenetics studies revealed monosomy 7. Acute myeloid leukemia appears 3 months after training rapid patient's death.


CONCLUSIONS
Blood examination is necessary before to conclude idiopathic central diabetes insipidus. The discovery of chronic myelomonocytic leukemia implicates a rapid managing before its possible acute myeloid leukemia transformation. Indeed, prognosis of central diabetes insipidus and acute myeloid leukemia associated, in presence of monosomy 7, is very poor.
Graffin
B
B
Service de médecine interne, HIA Sainte-Anne, 83800 Toulon-Armées, France. graffin-bruno@noos.fr
Bernard
P
P
Landais
C
C
Gisserot
O
O
Aletti
M
M
Leyral
G
G
Paris
J-F
JF
Carli
P
P
D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D003919:Diabetes Insipidus / Q000175:diagnosis*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009006:Monosomy / Q000175:diagnosis / Q000235:genetics