title: [Poor prognosis childhood cancers].
abstract: Poor prognosis childhood cancers are mainly metastatic diseases represented by stage IV neuroblastomas developed in children more than one year and metastatic Ewing tumours. These both diseases are chemosensitive but not curable with conventional chemotherapy. In these indications, high-dose chemotherapy with autologous peripheral blood stem cells transplantation is delivered in patients achieving a good partial remission with conventional treatment. The toxicity of these procedures is high but manageable; these approaches have improved the prognosis of these patients.
authors.affiliation: Département de pédiatrie, institut Gustave-Roussy, 94805 Villejuif Cedex. valteau@igr.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: Valteau-Couanet
authors.forename: Véronique
authors.initials: V
authors.lastname: Minard
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D009367:Neoplasm Staging; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D009447:Neuroblastoma / Q000556:secondary / Q000628:therapy; D011379:Prognosis; D012074:Remission Induction; D012512:Sarcoma, Ewing / Q000556:secondary / Q000628:therapy; D019172:Transplantation Conditioning / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents