[Serum proteomics study of chronic gastritis with dampness syndrome in traditional Chinese medicine].
OBJECTIVE
To explore microcosmic information in chronic gastritis dampness syndrome by using serum proteomics of patients with chronic gastritis dampness syndrome.


METHODS
Serum proteomics of 18 dampness syndrome cases, 17 non-dampness syndrome cases in chronic gastritis patients and 8 normal controls were analyzed by surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) protein-chip.


RESULTS
There was a high expression trend in three ratios of charge (of an electron) to mass (M/S) of 3.2 kD, 6.4 kD and 8.1 kD of protein expression spectrum from patients with chronic gastritis dampness syndrome, and the wave peak value was over 10 units. There was a low expression trend in above-mentioned sites of protein expression spectrum from patients with chronic gastritis non-dampness syndrome and normal group. The wave peak value of patients with chronic gastritis non-dampness syndrome was about or below 10 units, and the wave peak value in normal group was below 5 units.


CONCLUSIONS
There exists a certain significance to explore biologic theory basis of chronic gastritis dampness syndrome by analyzing the serum proteomics.
Wang
Yi-qin
YQ
Laboratory of Syndromes of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. wangyiqin2380@sina.com
Li
Fu-feng
FF
Wang
Wen-jing
WJ
Zhao
Li-yu
LY
Guo
Li
L
Wang
Hui-fang
HF
D001798:Blood Proteins / Q000032:analysis*; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D005756:Gastritis / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods
D001798:Blood Proteins