title: The long-term survival of simultaneous pancreas and kidney transplant with basiliximab induction therapy.
abstract: Interleukin-2 receptor (IL2R) antibody has emerged as an attractive induction therapy for organ transplant. However, the long-term outcome of basiliximab induction in simultaneous pancreas and kidney (SPK) transplant remains speculative. We retrospectively analyzed the long-term survivals of 91 consecutive SPK recipients with basiliximab as induction, combination of steroid, tacrolimus (TAC) and mycophenolate acid (MFA)--either mycophenolate mofetil (MMF) or sodium mycophenolate (myfortic) as maintenance. At one, three, five, and seven-yr, the actual patient survival rate were 91.2%, 90.3%, 88.1%, and 88.2%, respectively; kidney graft survivals were 90.1%, 84.7%, 78.6%, and 70.6%, respectively; and pancreas graft survivals were 86.8%, 80.6%, 71.4%, and 58.8% respectively. There was a low incidence of rejection and CMV infection. Basiliximab induction with TAC, MFA, and steroid maintenance therapy can provide excellent long-term outcome for SPK recipients.
authors.affiliation: Tulane Abdominal Transplant Institute, Tulane University Health Sciences Center, New Orleans, LA, USA. rzhang@tulane.edu
authors.forename: Rubin
authors.initials: R
authors.lastname: Zhang
authors.forename: Sandy
authors.initials: S
authors.lastname: Florman
authors.forename: Sharmila
authors.initials: S
authors.lastname: Devidoss
authors.forename: April
authors.initials: A
authors.lastname: Zarifian
authors.forename: Mary
authors.initials: M
authors.lastname: Killackey
authors.forename: Anil
authors.initials: A
authors.lastname: Paramesh
authors.forename: Vivian
authors.initials: V
authors.lastname: Fonseca
authors.forename: Vecihi
authors.initials: V
authors.lastname: Batuman
authors.forename: L Lee
authors.initials: LL
authors.lastname: Hamm
authors.forename: Douglas
authors.initials: D
authors.lastname: Slakey
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000077552:Basiliximab; D005260:Female; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use*; D012189:Retrospective Studies; D017741:Survivors; D019172:Transplantation Conditioning / Q000379:methods
chemical_list: D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents; D011993:Recombinant Fusion Proteins; D000077552:Basiliximab