title: [(11)C]-PIB imaging in patients with Parkinson's disease: preliminary results.
abstract: [(11)C]-PIB positron emission tomography ([(11)C]-PIB PET) is a sensitive marker of amyloid in Alzheimer's disease (AD), but its specificity has not been fully evaluated. Vascular amyloid-beta deposition is common in Parkinson's disease (PD) and alpha-synuclein, the major component of the Lewy bodies in PD, forms amyloid fibrils. We investigated five apparently cognitively normal PD patients with [(11)C]-PIB PET. The results were compared to 16 patients with AD and six healthy controls from a previous study. [(11)C]-PIB retention was not significantly increased in our patients who all had early stage PD. Further studies of more advanced PD patients are warranted.
authors.affiliation: Department of Neurology, University Hospital, SE-751 85 Uppsala, Sweden. anders.johansson@neurologi.uu.se
authors.forename: A
authors.initials: A
authors.lastname: Johansson
authors.forename: I
authors.initials: I
authors.lastname: Savitcheva
authors.forename: A
authors.initials: A
authors.lastname: Forsberg
authors.forename: H
authors.initials: H
authors.lastname: Engler
authors.forename: B
authors.initials: B
authors.lastname: Långström
authors.forename: A
authors.initials: A
authors.lastname: Nordberg
authors.forename: H
authors.initials: H
authors.lastname: Askmark
mesh_terms: D000368:Aged; D000814:Aniline Compounds; D052160:Benzothiazoles / Q000378:metabolism*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D052160:Benzothiazoles; D013844:Thiazoles