title: Patient assessed symptoms are poor predictors of objective findings. Results from a cross sectional study in patients treated with radiotherapy for pharyngeal cancer.
abstract: BACKGROUND
  The aim of the study was to assess the value of the EORTC questionnaires C30 and H&N35, as an instrument for the study of side effects.
  
  
  METHODS
  We invited all recurrence free patients, treated with radical radiotherapy for pharyngeal cancer between 1998 and 2002 at our institution, to participate in the study. Data was retrieved using questionnaires, functional endoscopic evaluation of swallowing, dental examination with orthopantomography and saliva flow measurements. Thirty-five (55% of invited) participated.
  
  
  RESULTS
  Side effects were omnipresent and often severe. The value of patient assessed symptom scores to predict equivalent objective changes was varied: We found a sensitivity of 0.59-0.93, specificity of 0.40-0.81, positive predictive value of 0.28-0.81 and a negative predictive value of 0.46-0.94.
  
  
  CONCLUSIONS
  The questionnaire should be used to retrieve information on subjective side effects and objective examination should be used for objective changes. One cannot conclude from one to the other.
authors.affiliation: Department of Oncology, Aarhus University Hospital, Aarhus, Denmark. kennethjensen@dadlnet.dk
authors.forename: Kenneth
authors.initials: K
authors.lastname: Jensen
authors.forename: Karin
authors.initials: K
authors.lastname: Lambertsen
authors.forename: Peter
authors.initials: P
authors.lastname: Torkov
authors.forename: Martin
authors.initials: M
authors.lastname: Dahl
authors.forename: Anders Bonde
authors.initials: AB
authors.lastname: Jensen
authors.forename: Cai
authors.initials: C
authors.lastname: Grau
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003680:Deglutition Disorders / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000532:radiotherapy*; D010808:Physical Examination; D011379:Prognosis; D011788:Quality of Life; D011832:Radiation Injuries / Q000175:diagnosis* / Q000523:psychology; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D012680:Sensitivity and Specificity; D012907:Smoking / Q000009:adverse effects; D012923:Social Class; D009057:Stomatognathic Diseases / Q000209:etiology; D011795:Surveys and Questionnaires; D014987:Xerostomia / Q000209:etiology