Solventless lactam synthesis by intramolecular cyclizations of alpha-iminoester derivatives under microwave irradiation.
We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation.
Zradni
Fatima-Zohra
FZ
Faculté des Sciences, Département de Chimie, Université d'Es-sénia, Oran, B.P 1524, Algeria. fzradnidz@yahoo.fr
Hamelin
Jack
J
Derdour
Aicha
A
D000478:Alkylation; D003500:Cyclization; D004952:Esters / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D011827:Radiation; D012997:Solvents / Q000737:chemistry*; D013696:Temperature
D004952:Esters; D007097:Imines; D007769:Lactams; D012997:Solvents