title: Oxygenation and release of inflammatory mediators after off-pump compared with after on-pump coronary artery bypass surgery.
abstract: BACKGROUND
  In a previous study, we showed that oxygenation was impaired for up to 5 day after conventional coronary artery bypass grafting (CABG). As cardiopulmonary bypass (CPB) may have a detrimental effect on pulmonary function, we hypothesized that coronary revascularization grafting without the use of CPB (OPCAB) would affect post-operative oxygenation and release of inflammatory mediators less compared with CABG.
  
  
  METHODS
  Low-risk patients scheduled for elective coronary revascularization were randomly assigned to one of two groups (CABG, n = 17 or OPCAB, n = 18). Two parameters of oxygenation, shunt (%) and ventilation-perfusions mismatch, described as DeltaPO(2) (kPa), were estimated for up to 5 days post-operatively. Systemic release of interleukin (IL)-6, -8 and -10, C-reactive protein (CRP) and neutrophils were measured in peripheral blood samples for up to 3 days post-operatively. The lungs participation in the cytokine response was evaluated from mixed venous blood samples taken within the first 16 h post-operatively.
  
  
  RESULTS
  OPCAB was followed by a higher shunt (P = 0.047), with no difference (P = 0.47) in the deterioration of DeltaPO(2) between the groups. OPCAB was followed by an attenuated systemic release of IL-8 (P = 0.041) and IL-10 (P = 0.006), while the release of IL-6 (P = 0.94), CRP (P = 0.121) and neutrophils (P = 0.078) did not differ between the groups. Indications of an uptake of cytokines in the lungs were found after OPCAB.
  
  
  CONCLUSIONS
  When comparing OPCAB with CABG, oxygenation was more affected and only part of the systemic inflammatory response was attenuated.
authors.affiliation: Department of Anaesthesia, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Denmark. bodil.steen.rasmussen@rn.dk
authors.forename: B S
authors.initials: BS
authors.lastname: Rasmussen
authors.forename: H
authors.initials: H
authors.lastname: Laugesen
authors.forename: J
authors.initials: J
authors.lastname: Sollid
authors.forename: J
authors.initials: J
authors.lastname: Grønlund
authors.forename: S E
authors.initials: SE
authors.lastname: Rees
authors.forename: E
authors.initials: E
authors.lastname: Toft
authors.forename: J
authors.initials: J
authors.lastname: Gjedsted
authors.forename: C
authors.initials: C
authors.lastname: Dethlefsen
authors.forename: E
authors.initials: E
authors.lastname: Tønnesen
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D002097:C-Reactive Protein / Q000032:analysis; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D047549:Coronary Artery Bypass, Off-Pump; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D010100:Oxygen / Q000097:blood*; D012307:Risk Factors; D013997:Time Factors; D020107:Troponin T / Q000097:blood; D014692:Ventilation-Perfusion Ratio
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8; D020107:Troponin T; D016753:Interleukin-10; D002097:C-Reactive Protein; D010100:Oxygen