title: Intravenous magnesium sulphate provides no additive benefit to standard management in acute asthma.
abstract: BACKGROUND
  Treatment of acute asthma is based on rapid reversal of bronchospasm and airway inflammation. Magnesium sulphate (MgSO(4)) is known to have a bronchodilator effect on smooth muscle but studies have shown conflicting results on its efficacy in acute asthma, although its use is recommended in national and international guidelines.
  
  
  OBJECTIVE
  To determine if intravenous MgSO(4), when used as an adjunct to standard therapy, improves the outcome in acute asthma.
  
  
  METHODS
  A double blind, randomised placebo controlled trial comparing 1.2g MgSO(4) with standard therapy in adult patients with acute asthma. Patients had a PEF <or=75% predicted and all were treated with oxygen, nebulised salbutamol and ipratropium, and IV hydrocortisone. They then received 1.2g IV MgSO(4) or placebo. Outcome measures were % predicted PEF at 60 min and hospital admission rates.
  
  
  RESULTS
  One hundred and twenty nine patients were studied. Placebo and active treatment groups were well matched at baseline. MgSO(4) had no benefit with regards hospital admission rates or % predicted PEF at 60 min (p=0.48) for the whole group, or for subgroups of life-threatening (p=0.85), severe (p=0.63) and moderate (p=0.67) acute asthma.
  
  
  CONCLUSIONS
  This study did not show additional benefit from 1.2g IV MgSO(4) when given as an adjunct to standard therapy for acute asthma.
authors.affiliation: Respiratory Unit, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK. tbradshaw@fsmail.net
authors.forename: Tracey A
authors.initials: TA
authors.lastname: Bradshaw
authors.forename: Simon P
authors.initials: SP
authors.lastname: Matusiewicz
authors.forename: Graham K
authors.initials: GK
authors.lastname: Crompton
authors.forename: J Alastair
authors.initials: JA
authors.lastname: Innes
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Greening
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D004333:Drug Administration Routes; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents; D008278:Magnesium Sulfate