Emerging roles of proteases in tumour suppression.
Proteases have long been associated with cancer progression because of their ability to degrade extracellular matrices, which facilitates invasion and metastasis. However, recent studies have shown that these enzymes target a diversity of substrates and favour all steps of tumour evolution. Unexpectedly, the post-trial studies have also revealed proteases with tumour-suppressive effects. These effects are associated with more than 30 different enzymes that belong to three distinct protease classes. What are the clinical implications of these findings?
López-Otín
Carlos
C
Carlos López-Otín is at the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain. CLO@uniovi.es
Matrisian
Lynn M
LM
D051722:ADAM Proteins / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D020169:Caspases / Q000378:metabolism; D002403:Cathepsins / Q000378:metabolism; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000378:metabolism; D004195:Disease Models, Animal; D018450:Disease Progression; D016503:Drug Delivery Systems / Q000379:methods; D058851:GPI-Linked Proteins; D006801:Humans; D007610:Kallikreins / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D015260:Neprilysin / Q000378:metabolism; D010447:Peptide Hydrolases / Q000145:classification / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism; D000099271:Prostasin
D051722:ADAM Proteins; D000970:Antineoplastic Agents; D020169:Caspases; D002403:Cathepsins; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D058851:GPI-Linked Proteins; D007610:Kallikreins; D020782:Matrix Metalloproteinases; D008565:Membrane Proteins; D015260:Neprilysin; D010447:Peptide Hydrolases; D012697:Serine Endopeptidases; D025801:Ubiquitin; D000099271:Prostasin; C120203:PRSS21 protein, human