title: Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register.
abstract: OBJECTIVE
  The first Argentine experience with epidemiologic, molecular, and genetic counseling data is reported.
  
  
  METHODS
  We analyzed 43 families fulfilling Amsterdam criteria identified from a prospective database with data from 779 relatives.
  
  
  RESULTS
  Eleven families (25.6 percent) presented as Lynch I, 29 (67.4 percent) as Lynch II, and 3 (7 percent) as Muir-Torre syndrome. Among the 306 affected members, 197 cases of colorectal cancer were identified (mean age at diagnosis, 52.1 (range, 21-90) years). The most frequent extracolonic tumors were gastric adenocarcinoma in males and endometrium adenocarcinoma in females. A high incidence of breast cancer was observed (16 cases among 155 females, crude rate: 11,594.20/100,000). Twenty-seven patients (8.8 percent) developed more than one tumor. These patients were younger than those with only one tumor (45 vs. 51 years; P = 0.001). In 5 of 11 patients who underwent molecular sequencing, a pathologic mutation was found. A novel C deletion at 1910 nucleotide, codon 637, exon 12 of MSH2 gene was identified in a family with a strong aggregation of breast cancer with lack of MSH2 immunohistochemical staining. For 78.2 percent of counseled individuals, this session represented the first time they received information, and 73.9 percent stated that their physicians were unaware of their family background.
  
  
  CONCLUSIONS
  Argentine families presented a high incidence of stomach cancer. The elevated incidence of breast cancer and its association with a novel hMSH2 mutation bring to consideration the inclusion of this malignancy as part of the syndrome. A lack of awareness by both physicians and persons at risk was observed.
authors.affiliation: Department of Colorectal Surgery, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. carlos.vaccaro@hospitalitaliano.org.ar
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Vaccaro
authors.forename: Fernando
authors.initials: F
authors.lastname: Bonadeo
authors.forename: Analía V
authors.initials: AV
authors.lastname: Roverano
authors.forename: Paivi
authors.initials: P
authors.lastname: Peltomaki
authors.forename: Shashi
authors.initials: S
authors.lastname: Bala
authors.forename: Elise
authors.initials: E
authors.lastname: Renkonen
authors.forename: Maria A
authors.initials: MA
authors.lastname: Redal
authors.forename: Esteban
authors.initials: E
authors.lastname: Mocetti
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mullen
authors.forename: Guillermo
authors.initials: G
authors.lastname: Ojea-Quintana
authors.forename: Mario L
authors.initials: ML
authors.lastname: Benati
authors.forename: Hernan Garcia
authors.initials: HG
authors.lastname: Rivello
authors.forename: Mary B
authors.initials: MB
authors.lastname: Clark
authors.forename: Jane F
authors.initials: JF
authors.lastname: Lynch
authors.forename: Henry T
authors.initials: HT
authors.lastname: Lynch
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001118:Argentina / Q000453:epidemiology; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D008297:Male; D008875:Middle Aged; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D010375:Pedigree; D012017:Referral and Consultation; D012042:Registries
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C501486:MLH1 protein, human; D009687:Nuclear Proteins; C497172:MSH2 protein, human; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein