Acute lower limb ischemia as the initial symptom of acute myeloid leukemia.
Although coagulatory system disorders are well recognized in patients with acute leukemia, these usually present with either hemorrhagic complications or thrombosis of small vessels. Large vessel thrombosis is a very rare clinical presentation. We present a patient with previously undiagnosed acute myeloid leukemia (M5), who was referred to our hospital with symptoms of acute ischemia of his right lower limb. Occlusion of the right external iliac artery due to a combination of leucostasis and coagulation disorders was noted and successfully treated with urgent leukapheresis, immediate chemotherapy and surgical thromboembolectomy.
Kafetzakis
Alexandros
A
Vascular Surgery Division, University of Crete Medical School, Heraklion, Greece.
Foundoulakis
Andreas
A
Ioannou
Christos V
CV
Stavroulaki
Emilia
E
Koutsopoulos
Anastassios
A
Katsamouris
Asterios N
AN
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007511:Ischemia / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D007866:Leg / Q000098:blood supply* / Q000601:surgery; D007937:Leukapheresis; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology; D012907:Smoking; D017131:Thrombectomy; D013927:Thrombosis / Q000209:etiology
D000970:Antineoplastic Agents