title: [Observation on the therapeutic effect of ear point combined therapy on common migraine at the remission stage and effects on plasma CGRP and ET in the patient].
abstract: OBJECTIVE
  To probe into the therapeutic effect of ear point combined therapy on common migraine at the remission stage and the mechanism.
  
  
  METHODS
  Thirty-two cases of common migraine at the remission stage were treated with ear point combined therapy, including blood-letting at ear back, injection of autoblood into Fengchi (GB 20), Yanglingquan (GB 34), and pricking at ear points Nie, Yi-dan (pancreas and gallbladder), Shenmen, etc.. Clinical therapeutic effect was evaluated at the end of one therapeutic course, and calcitonin gene-related peptide (CGRP) and endotheline (ET) were detected before and after treatment, and the CGRP and ET contents were compared with those in 22 normal persons.
  
  
  RESULTS
  The effective rate was 78.1% (P<0.001), CGRP and ET contents had very significant changes after treatment (P<0.01), and CGRP and ET showed negative correlativity (P<0.05).
  
  
  CONCLUSIONS
  The ear point combined therapy can regulates the balance between the plasma CGRP and ET in the patient of common migraine and improve vasodilative, vasoconstrictive and endothelial fuctions in the brain, hence stopping pain.
authors.affiliation: Acupuncture Department, Affiliated Hospital of Shandong University of TCM, Jinan 250011, China. yangdianhui@sohu.com
authors.forename: Dian-hui
authors.initials: DH
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.forename: Qiu-hua
authors.initials: QH
authors.lastname: Shan
mesh_terms: D020831:Acupuncture, Ear / Q000379:methods*; D000293:Adolescent; D000328:Adult; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020326:Migraine without Aura / Q000097:blood / Q000503:physiopathology / Q000628:therapy*
chemical_list: D016232:Endothelins; D015740:Calcitonin Gene-Related Peptide