Serum cytokine levels in active uveitis and remission.
Serum levels of interleukin(IL)-8, IL-6, and (TNF)-alpha were measured in 25 patients during active uveitis and uveitis in remission and compared to age-matched controls. Levels of IL-8 and IL-6 were significantly elevated in patients with active disease and were decreased during remission. IL-8 levels were highest in patients with anterior uveitis, with greatest difference between active disease and remission. No consistent pattern was observed for TNF-alpha. In conclusion, serum cytokine levels are elevated in active noninfectious uveitis. The rise in IL-8 may suggest innate immune mechanisms in the acute disease, while IL-6 participates in modulation of inflammation in the chronic disease.
Kramer
M
M
Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel. mkramer@netvision.net.il
Monselise
Y
Y
Bahar
I
I
Cohen
Y
Y
Weinberger
D
D
Goldenberg-Cohen
N
N
D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D015864:Panuveitis / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014606:Uveitis, Anterior / Q000097:blood*; D015866:Uveitis, Posterior / Q000097:blood*
C508606:CXCL8 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha