title: Prediction of symptom remission in schizophrenia during inpatient treatment.
abstract: OBJECTIVE
  Standardized consensus criteria for remission in schizophrenia were recently proposed. The present study applied the symptom-severity component of these criteria to a sample of inpatients in order to determine the rates of remission during inpatient treatment and to explore predictors of remission.
  
  
  METHODS
  A total of 288 inpatients from a multi-centre follow-up programme who fulfilled ICD-10 criteria for schizophrenia were included in the present analyses. PANSS ratings at admission and at discharge from hospitalization were used to examine remission status. Clinical and sociodemographic variables at admission were tested for their ability to predict remission at discharge.
  
  
  RESULTS
  In total, 55% of the sample achieved symptom remission during inpatient treatment; 84% percent showed remission with respect to 'reality distortion', 85% with respect to 'disorganization' and only 65% with respect to 'negative symptoms'. Logistic regression analysis revealed that the global functioning (GAF) in the year before admission, the total score of the Strauss-Carpenter Prognostic Scale and the PANSS negative subscore at admission were predictive for symptom remission. The regression model showed a predictive value of about 70% and explained 36% of the observed variance.
  
  
  CONCLUSIONS
  The results highlight the impact of negative symptoms for the course and treatment response of schizophrenic illness.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany. Markus.Jaeger@bkh-guenzburg.de
authors.forename: Markus
authors.initials: M
authors.lastname: Jäger
authors.forename: Michael
authors.initials: M
authors.lastname: Riedel
authors.forename: Max
authors.initials: M
authors.lastname: Schmauss
authors.forename: Gerd
authors.initials: G
authors.lastname: Laux
authors.forename: Herbert
authors.initials: H
authors.lastname: Pfeiffer
authors.forename: Dieter
authors.initials: D
authors.lastname: Naber
authors.forename: Lutz G
authors.initials: LG
authors.lastname: Schmidt
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Gaebel
authors.forename: Joachim
authors.initials: J
authors.lastname: Klosterkötter
authors.forename: Isabella
authors.initials: I
authors.lastname: Heuser
authors.forename: Kai-Uwe
authors.initials: KU
authors.lastname: Kühn
authors.forename: Matthias R
authors.initials: MR
authors.lastname: Lemke
authors.forename: Eckart
authors.initials: E
authors.lastname: Rüther
authors.forename: Gerd
authors.initials: G
authors.lastname: Buchkremer
authors.forename: Markus
authors.initials: M
authors.lastname: Gastpar
authors.forename: Ronald
authors.initials: R
authors.lastname: Bottlender
authors.forename: Anton
authors.initials: A
authors.lastname: Strauss
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Möller
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006760:Hospitalization; D006801:Humans; D038801:International Classification of Diseases; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D012559:Schizophrenia / Q000175:diagnosis / Q000628:therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome; D055815:Young Adult