Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.
Tan
Zheng
Z
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. tzheng@bsd.uchicago.edu
Randall
Glenn
G
Fan
Jihua
J
Camoretti-Mercado
Blanca
B
Brockman-Schneider
Rebecca
R
Pan
Lin
L
Solway
Julian
J
Gern
James E
JE
Lemanske
Robert F
RF
Nicolae
Dan
D
Ober
Carole
C
D020413:3' Untranslated Regions; D000483:Alleles; D001249:Asthma / Q000235:genetics* / Q000276:immunology*; D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D020413:3' Untranslated Regions; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D035683:MicroRNAs