title: [Early diagnosis of invasive fungal infections caused by Aspergillus and other emerging mycelial fungi].
abstract: The usefulness of surrogate markers in the diagnosis of invasive fungal infections caused by Aspergillus and other emerging mycelial fungi is based on the ability of surrogate markers to detect the infection caused by different species of mycelial fungi. Conventional microbiological methods for diagnosis of fungal disease are slow and insensitive. Antigen based assays or measurement of (1-3)-beta-D-glucan in blood have been developed and validated in clinical laboratories. We review these diagnostic contemporary tools, their clinical application and impact.
authors.affiliation: Unidad de Micología, Servicio de Microbiología, Hospital Doce de Octubre, Madrid, Spain. apalacioh.hdoc@salud.madrid.org
authors.forename: Amalia
authors.initials: A
authors.lastname: del Palacio
authors.forename: Almudena
authors.initials: A
authors.lastname: Alhambra
authors.forename: María Soledad
authors.initials: MS
authors.lastname: Cuétara
authors.forename: José
authors.initials: J
authors.lastname: Pontón
mesh_terms: D000908:Antibodies, Fungal / Q000097:blood; D000946:Antigens, Fungal / Q000097:blood; D001228:Aspergillosis / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers; D002986:Clinical Trials as Topic; D021821:Communicable Diseases, Emerging / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D004271:DNA, Fungal / Q000097:blood; D042241:Early Diagnosis; D016469:Fungemia / Q000175:diagnosis / Q000453:epidemiology; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D007158:Immunologic Techniques; D008351:Mannans / Q000097:blood; D011237:Predictive Value of Tests; D011509:Proteoglycans; D012307:Risk Factors; D020096:Zygomycosis / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D047071:beta-Glucans / Q000097:blood
chemical_list: D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D015415:Biomarkers; D004271:DNA, Fungal; D008351:Mannans; D011509:Proteoglycans; D047071:beta-Glucans; C012990:galactomannan; C010770:polysaccharide-K; D005690:Galactose