title: Subclinical neurological abnormalities in children with celiac disease receiving a gluten-free diet.
abstract: OBJECTIVE
  Because clinically evident manifestations are frequent in adults with celiac disease (CD), we aimed to investigate whether early neurological abnormalities may be detected in children with CD.
  
  
  METHODS
  Electroencephalography, electromyography, and somatosensory evoked potentials were performed in children with CD receiving a gluten-free diet.
  
  
  RESULTS
  The neurophysiological tests revealed subclinical neurological abnormalities associated with CD in 3 (11%) of 27 children: 2 had peripheral polyneuropathy documented with electromyography, and 1 had prolonged latencies in somatosensory evoked potential. Magnetic resonance imaging showed abnormalities in 2 (7.4%) of children: pontine demyelinization in 1 and cortical atrophy in the other.
  
  
  CONCLUSIONS
  Because the rate of neurological problems is increased in children with CD, neurological abnormalities should be carefully investigated early after the diagnosis of CD is made.
authors.affiliation: Department of Pediatrics, Ege University Medical School, Izmir, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Cakir
authors.forename: A
authors.initials: A
authors.lastname: Tosun
authors.forename: M
authors.initials: M
authors.lastname: Polat
authors.forename: N
authors.initials: N
authors.lastname: Celebisoy
authors.forename: S
authors.initials: S
authors.lastname: Gokben
authors.forename: S
authors.initials: S
authors.lastname: Aydogdu
authors.forename: R V
authors.initials: RV
authors.lastname: Yagci
authors.forename: H
authors.initials: H
authors.lastname: Tekgul
mesh_terms: D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002648:Child; D003430:Cross-Sectional Studies; D004569:Electroencephalography; D004576:Electromyography; D005073:Evoked Potentials, Somatosensory; D005260:Female; D005983:Glutens / Q000008:administration & dosage* / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D009482:Neurophysiology; D015995:Prevalence
chemical_list: D005983:Glutens