A case of mixed intoxication with isopropyl alcohol and propanol-1 after ingestion of a topical antiseptic solution.
We report a mixed intoxication with isopropyl alcohol and propanol-1 in a hospitalized patient who ingested, on two separate days, two 100 ml bottles of a topical antiseptic solution containing isopropyl alcohol and propanol-1. Eight hours after the second ingestion, plasma concentrations of isopropanol, propanol-1 and acetone were 37 mg/dL, <10 mg/dL, and 227 mg/dl, respectively. Despite a lack of severe toxicity, 4-methylpyrazole (fomepizole) was initiated. This case points out the need to limit access to alcohol-containing antiseptic solutions on wards where alcoholic and psychotic patients are hospitalized.
Blanchet
Benoit
B
Laboratory of Pharmacology and Toxicology, CHU Henri Mondor, Créteil, France. benoit.blanchet@hmn.ap-hop-paris.fr
Charachon
Antoine
A
Lukat
Stéphanie
S
Huet
Estelle
E
Hulin
Anne
A
Astier
Alain
A
D000433:1-Propanol / Q000506:poisoning*; D019840:2-Propanol / Q000506:poisoning*; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000506:poisoning*; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D000077604:Fomepizole; D006801:Humans; D011041:Poisoning / Q000188:drug therapy; D011720:Pyrazoles / Q000008:administration & dosage / Q000627:therapeutic use; D013406:Suicide, Attempted / Q000523:psychology; D016896:Treatment Outcome
D000891:Anti-Infective Agents, Local; D000931:Antidotes; D004338:Drug Combinations; D011720:Pyrazoles; D000077604:Fomepizole; D000433:1-Propanol; D019840:2-Propanol