title: Cost-effectiveness of annual targeted larviciding campaigns in Cambodia against the dengue vector Aedes aegypti.
abstract: OBJECTIVE
  To assess the cost-effectiveness (CE) of annual targeted larviciding campaigns from 2001 to 2005 against the dengue vector Aedes aegypti in two urban areas of Cambodia with a population of 2.9 million people.
  
  
  METHODS
  The intervention under analysis consisted of annual larviciding campaigns targeting medium to large water storage containers in households and other premises. The CE compared the intervention against the hypothetical alternative of no intervention. The CE was calculated as the ratio of disability adjusted life years (DALYs) saved to the net cost of the intervention (in 2005 US dollars) by year. A sensitivity analysis explored the range of study parameters.
  
  
  RESULTS
  The intervention reduced the number of dengue cases and deaths by 53%. It averted an annual average of 2980 dengue hospitalizations, 11,921 dengue ambulatory cases and 23 dengue deaths, resulting in a saving of 997 DALYs per year. The gross cost of the intervention was US $567,800 per year, or US $0.20 per person covered. As the intervention averted considerable medical care, the annual net cost of the intervention was US $312,214 (US $0.11 per person covered) from a public sector perspective and US $37,137 (US $0.01 per person covered) from a societal perspective. The resulting CE ratios were: US $313/DALY gained from the public perspective and US $37/DALY gained from the societal perspective. Even under the most conservative assumption, the intervention remained cost effective from both perspectives.
  
  
  CONCLUSIONS
  Annual, targeted larviciding campaigns appear to have been effective and cost-effective medium-term interventions to reduce the epidemiologic and economic burden of dengue in urban areas of Cambodia.
authors.affiliation: Schneider Institutes for Health Policy, Heller School, Brandeis University, Waltham, MA 02454-9110, USA. suaya@brandeis.edu
authors.forename: Jose A
authors.initials: JA
authors.lastname: Suaya
authors.forename: Donald S
authors.initials: DS
authors.lastname: Shepard
authors.forename: Moh-Seng
authors.initials: MS
authors.lastname: Chang
authors.forename: Mariana
authors.initials: M
authors.lastname: Caram
authors.forename: Stefan
authors.initials: S
authors.lastname: Hoyer
authors.forename: Duong
authors.initials: D
authors.lastname: Socheat
authors.forename: Ngan
authors.initials: N
authors.lastname: Chantha
authors.forename: Michael B
authors.initials: MB
authors.lastname: Nathan
mesh_terms: D000330:Aedes / Q000187:drug effects; D000818:Animals; D002160:Cambodia / Q000453:epidemiology; D003362:Cost-Benefit Analysis; D003365:Costs and Cost Analysis; D003715:Dengue / Q000453:epidemiology / Q000517:prevention & control*; D003716:Dengue Virus; D004196:Disease Outbreaks / Q000517:prevention & control*; D006801:Humans; D007303:Insect Vectors; D009032:Mosquito Control / Q000191:economics*