HLA analysis of Sri Lankan Sinhalese predicts North Indian origin.
The origin of the Sinhalese population of Sri Lanka is debated. We subtyped HLA-A*02 in 101 Sinhalese and observed a preponderance of the rare allele HLA-A*0211 which was similar to reported frequencies in northern India. Taken with low-resolution typing for the remaining A, B, C, DR and DQ alleles, these data suggest a North Indian origin for the Sri Lankan Sinhalese.
Malavige
G N
GN
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Rostron
T
T
Seneviratne
S L
SL
Fernando
S
S
Sivayogan
S
S
Wijewickrama
A
A
Ogg
G S
GS
D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics*; D015789:HLA-A2 Antigen; D006801:Humans; D007194:India / Q000208:ethnology; D013188:Sri Lanka / Q000208:ethnology
D006680:HLA Antigens; D015234:HLA-A Antigens; C524866:HLA-A*02 antigen; D015789:HLA-A2 Antigen