title: Efficient one-pot synthesis of biologically active polysubstituted aromatic amines.
abstract: An efficient and modular one-pot synthesis of polysubstituted aromatic amines by a mild reductive amination procedure is described and the biological potential of these nitrogen-centered compounds is demonstrated by growth inhibition of murine connective tissue cells and microscopy-based morphological studies.
authors.affiliation: Helmholtz-Zentrum für Infektionsforschung GmbH, Medizinische Chemie, Inhoffenstr 7, 38124 Braunschweig, Germany. dirk.menche@helmholtz-hzi.de
authors.forename: Dirk
authors.initials: D
authors.lastname: Menche
authors.forename: Fatih
authors.initials: F
authors.lastname: Arikan
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Sven
authors.initials: S
authors.lastname: Rudolph
authors.forename: Florenz
authors.initials: F
authors.lastname: Sasse
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D051379:Mice; D015394:Molecular Structure; D048328:Potoroidae; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D003603:Cytotoxins