Afterdischarges during cortical stimulation at different frequencies and intensities.
OBJECTIVE
The occurrence of unwanted afterdischarges (ADs) impedes cortical stimulation for mapping purposes. We investigated the safety of several stimulation paradigms.


METHODS
We compared the incidence of ADs and behavioral responses of two stimulation frequencies (50 and 100 Hz), at two intensities (1 and 0.2 ms pulse widths).


RESULTS
Stimulation with 100 Hz was more likely to cause ADs than 50 Hz, and stimulation using 1 ms pulse width was more likely to cause ADs than 0.2 ms.


CONCLUSIONS
Stimulation using 50 Hz frequency with a pulse width of 0.2 ms might be safer during cortical mapping.
Motamedi
Gholam K
GK
Department of Neurology, PHC 7, Georgetown University Hospital, 3800 Reservior Rd., NW, Washington, DC 20007, USA. Motamedi@georgetown.edu
Okunola
Oladotun
O
Kalhorn
Christopher G
CG
Mostofi
Navid
N
Mizuno-Matsumoto
Yuko
Y
Cho
Yong-Won
YW
Meador
Kimford J
KJ
D001519:Behavior; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation / Q000009:adverse effects; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged