title: The MTHFR 677C --> T polymorphism and risk of prostate cancer: results from the CAPS study.
abstract: The methylenetetrahydrafolate reductase (MTHFR) enzyme may influence cancer development by affecting DNA methylation, synthesis and repair. The MTHFR 677C-->T single nucleotide polymorphism (SNP) has been associated with decreased enzyme activity and has therefore been implicated in cancer development. We analyzed the MTHFR 677C-->T SNP in 2,777 incident prostate cancer cases and 1,639 population controls from the CAncer Prostate in Sweden study (CAPS). No significant association was found overall between prostate cancer risk and the 677C-->T SNP (p = 0.27) with heterozygote (CT) and homozygote (TT) allele carriers showing ORs of 1.12 (95% CI: 0.98-1.27) and 1.02 (95% CI: 0.80-1.30), respectively. In the subgroup of low risk prostate cancer, heterozygote-but not homozygote-allele carriers displayed a slight over-risk with an OR of 1.21 (95% CI: 1.03-1.41). Among men under 65 years of age, the 677C-->T SNP was associated with prostate cancer risk (p = 0.007), with odds ratios of 1.33 (95% CI: 1.09-1.63) for heterozygote allele carriers and 0.86 (95% CI: 0.6-1.24) for homozygote allele carriers. However, this association was attributed to a shift in the genotype distribution in the young controls. In conclusion, our results do not provide strong support for the hypothesis that the MTHFR 677C-->T polymorphism is related to prostate cancer risk.
authors.affiliation: Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University Hospital, Umeå 901 85, Sweden. Mattias.Johansson@oc.umu.se
authors.forename: Mattias
authors.initials: M
authors.lastname: Johansson
authors.forename: Bethany
authors.initials: B
authors.lastname: Van Guelpen
authors.forename: Johan
authors.initials: J
authors.lastname: Hultdin
authors.forename: Fredrik
authors.initials: F
authors.lastname: Wiklund
authors.forename: Hans-Olov
authors.initials: HO
authors.lastname: Adami
authors.forename: Katarina
authors.initials: K
authors.lastname: Bälter
authors.forename: Henrik
authors.initials: H
authors.lastname: Grönberg
authors.forename: Pär
authors.initials: P
authors.lastname: Stattin
mesh_terms: D000367:Age Factors; D000483:Alleles; D016022:Case-Control Studies; D019175:DNA Methylation; D004260:DNA Repair / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D045102:Methylenetetrahydrofolate Dehydrogenase (NAD+) / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D013548:Sweden
chemical_list: D045102:Methylenetetrahydrofolate Dehydrogenase (NAD+)