Proteasome and NF-kappaB inhibiting phaeophytins from the green alga Cladophora fascicularis.
Chemical examination of the green alga Cladophora fascicularis resulted in the isolation and characterization of a new porphyrin derivative, porphyrinolactone (1), along with five known phaeophytins 2-6 and fourteen sterols and cycloartanes. The structure of 1 was determined on the basis of spectroscopic analyses and by comparison of its NMR data with those of known phaeophytins. Compounds 1-6 displayed moderate inhibition of tumor necrosis factor alpha (TNF-alpha) induced nuclear factor-kappaB (NF-kappaB) activation, while 2 and 4 displayed potential inhibitory activity toward proteasome chymotripsin-like activation. The primary structure-activity relationship was also discussed.
Huang
Xinping
X
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, PR China.
Li
Min
M
Xu
Bo
B
Zhu
Xiaobin
X
Deng
Zhiwei
Z
Lin
Wenhan
W
D002734:Chlorophyll / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000460:Chlorophyta / Q000737:chemistry* / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D061988:Proteasome Inhibitors; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D016328:NF-kappa B; D061988:Proteasome Inhibitors; D014409:Tumor Necrosis Factor-alpha; D002734:Chlorophyll