title: Predicting odor pleasantness from odorant structure: pleasantness as a reflection of the physical world.
abstract: Although it is agreed that physicochemical features of molecules determine their perceived odor, the rules governing this relationship remain unknown. A significant obstacle to such understanding is the high dimensionality of features describing both percepts and molecules. We applied a statistical method to reduce dimensionality in both odor percepts and physicochemical descriptors for a large set of molecules. We found that the primary axis of perception was odor pleasantness, and critically, that the primary axis of physicochemical properties reflected the primary axis of olfactory perception. This allowed us to predict the pleasantness of novel molecules by their physicochemical properties alone. Olfactory perception is strongly shaped by experience and learning. However, our findings suggest that olfactory pleasantness is also partially innate, corresponding to a natural axis of maximal discriminability among biologically relevant molecules.
authors.affiliation: Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, Berkeley, California 94720, USA. rehan@berkeley.edu
authors.forename: Rehan M
authors.initials: RM
authors.lastname: Khan
authors.forename: Chung-Hay
authors.initials: CH
authors.lastname: Luk
authors.forename: Adeen
authors.initials: A
authors.lastname: Flinker
authors.forename: Amit
authors.initials: A
authors.lastname: Aggarwal
authors.forename: Hadas
authors.initials: H
authors.lastname: Lapid
authors.forename: Rafi
authors.initials: R
authors.lastname: Haddad
authors.forename: Noam
authors.initials: N
authors.lastname: Sobel
mesh_terms: D000328:Adult; D003431:Cross-Cultural Comparison; D004777:Environment; D005260:Female; D006801:Humans; D008297:Male; D009812:Odorants / Q000032:analysis; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D018035:Receptors, Odorant / Q000737:chemistry* / Q000502:physiology*; D021641:Recognition, Psychology / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D012903:Smell / Q000502:physiology*
chemical_list: D018035:Receptors, Odorant