title: [Transient chromosomal abnormalities following autologous peripheral blood stem cell transplantation for acute myelogenous leukemia].
abstract: Twenty-three patients with acute myelogenous leukemia (AML) have received autologous hematopoietic stem cell transplantation (autoHSCT) in our institute from 1997 to 2005. Among them, 3 patients relapsed, and the other 4 patients (17%) showed cytogenetic abnormalities after the autoHSCT. In these 4 patients with AML1/MTG8 or CBFbeta/MYH11 AML, RT-PCR findings using bone marrow cells were all negative when a cytogenetic abnormality was detected. Myelodysplasia was not detected in the bone marrow and no abnormal findings were seen in the peripheral blood. Cytogenetic abnormalities were detected 12-48 months after AutoHSCT, which disappeared in three patients and decreased in the remaining one patient with a median follow up time of 51 months (30-72 months) after their detection. We present our finding together with a review of the literature on post-autoHSCT cytogenetic abnormalities not related to relapse or secondary leukemia/myelodysplastic syndrome.
authors.affiliation: Division of Hematology, NTIT Kanto Medical Center.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Usuki
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakasone
authors.forename: Kazuki
authors.initials: K
authors.lastname: Taoka
authors.forename: Michiko
authors.initials: M
authors.lastname: Kida
authors.forename: Seiko
authors.initials: S
authors.lastname: Iki
authors.forename: Akio
authors.initials: A
authors.lastname: Urabe
mesh_terms: D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*