title: Regional cerebral blood flow using quantitative MR angiography.
abstract: OBJECTIVE
  We sought to derive regional cerebral blood flow using vessel flows from quantitative MR angiography (qMRA).
  
  
  METHODS
  Flow rates in the 15 major cerebral arteries were measured on retrospectively gated fast 2D phase-contrast MR angiography obtained in 83 healthy adult volunteers (age range, 24-74 years; mean, 42 years). The arterial network of the brain was partitioned into 12 different regions, in which flows were calculated from the measured flows of the 15 cerebral arteries.
  
  
  RESULTS
  The mean flows of the 15 arteries and the 12 regions were calculated. The mean total cranial flow and the mean total cerebral blood flow were 949 +/- 158 mL/min and 695 +/- 113 mL/min, respectively. The mean regional flows for the anterior and posterior circulation were 483 +/- 87 mL/min and 212 +/- 34 mL/min, respectively. The relative contributions of the flows in the 11 regions to their parent regions were obtained. The mean flows in the individual arteries and the regions with age were also calculated. The mean flows for the female group were significantly lower than those for the male group (P < .001) for the 2 common carotids and the cranial circulation and left/right extracranial circulation. However, the intracranial circulation was not different between sexes.
  
  
  CONCLUSIONS
  The 12 regions in the cerebral circulation were identified and formed into a partition tree, and the mean regional flow for each region was determined using vessel flows from qMRA.
authors.affiliation: Department of Neurosurgery, University of Illinois at Chicago, IL 60612-5970, USA. mzhao@uic.edu
authors.forename: M
authors.initials: M
authors.lastname: Zhao
authors.forename: S
authors.initials: S
authors.lastname: Amin-Hanjani
authors.forename: S
authors.initials: S
authors.lastname: Ruland
authors.forename: A P
authors.initials: AP
authors.lastname: Curcio
authors.forename: L
authors.initials: L
authors.lastname: Ostergren
authors.forename: F T
authors.initials: FT
authors.lastname: Charbel
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D000465:Algorithms; D017536:Carotid Artery, Common / Q000502:physiology; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012039:Regional Blood Flow; D012189:Retrospective Studies; D012737:Sex Factors