[Metabolic changes of lymphocytes and neoplastic cells in mice with Ehrlich ascites carcinoma during tumor growth].
Changes in the activities of NAD+- and NADP-dependent dehydrogenases of lymphocytes and tumor cells were studied in mice with Ehrlich ascites carcinoma, as well as changes in the concentrations of oxaloacetate, lactate, and NAD+ in the course of tumor growth. During the major period of tumor growth, conditions are produced in the lymphocytes for increased intensity of aerobic reactions directed at energy reproduction combined with a somewhat decreased intensity of synthetic processes. In the tumor cells, conditions predominantly arise for intensification of plastic metabolic reactions and reactions related to anaerobic energy reproduction.
Inzhevatkin
E V
EV
Fomenko
E Iu
EIu
Slepov
E V
EV
Savchenko
A A
AA
D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology* / Q000473:pathology; D004734:Energy Metabolism; D005260:Female; D019344:Lactic Acid / Q000378:metabolism; D008214:Lymphocytes / Q000201:enzymology* / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D062907:Oxaloacetic Acid / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*
D009243:NAD; D062907:Oxaloacetic Acid; D019344:Lactic Acid; D009249:NADP; D010088:Oxidoreductases