title: Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes.
abstract: The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes.
authors.affiliation: Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Schmidt
authors.forename: Birgit
authors.initials: B
authors.lastname: Herting
authors.forename: Silke
authors.initials: S
authors.lastname: Prieur
authors.forename: Susann
authors.initials: S
authors.lastname: Junghanns
authors.forename: Katherine
authors.initials: K
authors.lastname: Schweitzer
authors.forename: Christoph
authors.initials: C
authors.lastname: Globas
authors.forename: Ludger
authors.initials: L
authors.lastname: Schöls
authors.forename: Sabine
authors.initials: S
authors.lastname: Antoni
authors.forename: Dietmar
authors.initials: D
authors.lastname: Ferger
authors.forename: Heinz
authors.initials: H
authors.lastname: Reichmann
authors.forename: Helmut
authors.initials: H
authors.lastname: Wilhelm
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
authors.forename: Tjalf
authors.initials: T
authors.lastname: Ziemssen
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003624:Darkness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications; D010300:Parkinson Disease / Q000150:complications; D011680:Pupil / Q000502:physiology*; D013494:Supranuclear Palsy, Progressive / Q000209:etiology / Q000473:pathology*