Ir-catalyzed regio- and enantioselective decarboxylative allylic alkylations.
[Ir(COD)Cl]2/phosphoramidite ligand 1a was found to be an efficient catalytic system for the highly regio- and enantioselective decarboxylative alkylation of gamma-substituted allyl beta-ketocarboxylates, affording the branched products with up to >99/1 branched-linear ratio and 96% ee.
He
Hu
H
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
Zheng
Xiao-Jian
XJ
Li
Yi
Y
Dai
Li-Xin
LX
You
Shu-Li
SL