Synthesis and biological evaluation of rigid polycyclic derivatives of the Diels-Alder adduct tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione.
Part of our research program concentrates on the discovery of new bioactive compounds prepared either by total synthesis or molecular transformation of compounds with bioactivity profiles. In this work we have focused our interest on chemical transformations of the Diels-Alder adduct tricyclo[6.2.1.0(2,7)]undeca-4,9-dien-3,6-dione in order to obtain cage-like compounds and derivatives, followed by an evaluation of their biological activity.
Ito
Felicia Megumi
FM
Department of Chemistry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil. megumi@nin.ufms.br
Petroni
Jacqueline Marques
JM
de Lima
Dênis Pires
DP
Beatriz
Adilson
A
Marques
Maria Rita
MR
de Moraes
Manoel Odorico
MO
Costa-Lotufo
Letícia Veras
LV
Montenegro
Raquel Carvalho
RC
Magalhães
Hemerson Iury Ferreira
HI
Pessoa
Cláudia do O
Cdo O
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
D011083:Polycyclic Compounds