Convenient synthesis of highly functionalized pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition.
A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 nm, followed by spontaneous cycloaddition with a broad range of 1,3-dipolarophiles with excellent solvent compatibility, functional group tolerance, regioselectivity, and yield.
Wang
Yizhong
Y
Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Vera
Claudia I Rivera
CI
Lin
Qing
Q
D003500:Cyclization; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010777:Photochemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D009570:Nitriles; D011720:Pyrazoles