title: Antimalarial and antituberculous poly-O-acylated jatrophane diterpenoids from Pedilanthus tithymaloides.
abstract: Six new poly-O-acylated jatrophane diterpenes (1- 6) have been isolated along with five known compounds from the white latex of Pedilanthus tithymaloides. The structural identification was accomplished on the basis of 2D NMR and MS investigations. Some of these highly oxygenated jatrophane diterpenes possess a rare O-acetyl enol moiety. Compounds 1 and 3- 5 showed antiplasmodial activity with IC(50) values of 3.4-4.4 microg/mL and antimycobacterial activity against Mycobacterium tuberculosis with minimum inhibition concentration (MIC) values ranging from 12.5 to 100 microg/mL.
authors.affiliation: Department of Chemistry, Ramkhamhaeng University, Hua Mark, Bangkapi, Bangkok, Thailand.
authors.forename: Wantana
authors.initials: W
authors.lastname: Mongkolvisut
authors.forename: Somyote
authors.initials: S
authors.lastname: Sutthivaiyakit
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D019665:Euphorbiaceae / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010100:Oxygen / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013785:Thailand
chemical_list: D000962:Antimalarials; D000995:Antitubercular Agents; D004224:Diterpenes; D000666:Amphotericin B; D010100:Oxygen