title: Comparative activity of pradofloxacin against anaerobic bacteria isolated from dogs and cats.
abstract: OBJECTIVE
  To compare the intrinsic activity of pradofloxacin, a new fluoroquinolone developed for use in veterinary medicine, with other fluoroquinolones, against anaerobic bacteria isolated from dogs and cats.
  
  
  METHODS
  One hundred and forty-one anaerobes were isolated from dogs and cats and comparative MICs of pradofloxacin, marbofloxacin, enrofloxacin, difloxacin and ibafloxacin were determined according to standardized agar dilution methodology.
  
  
  RESULTS
  Pradofloxacin exerted the greatest antibacterial activity followed by marbofloxacin, enrofloxacin, difloxacin and ibafloxacin. Based on the distinctly lower MIC(50), MIC(90) and mode MIC values, pradofloxacin exhibited a higher in vitro activity than any of the comparator fluoroquinolones.
  
  
  CONCLUSIONS
  Pradofloxacin, a novel third-generation fluoroquinolone, has broad-spectrum anti-anaerobe activity and offers utility as single-drug therapy for mixed aerobic/anaerobic infections.
authors.affiliation: MB Consult Limited, Lymington, SO41 3TQ, UK. p-s@mbconsult.co.uk
authors.forename: Peter
authors.initials: P
authors.lastname: Silley
authors.forename: Bernd
authors.initials: B
authors.lastname: Stephan
authors.forename: Heinrich A
authors.initials: HA
authors.lastname: Greife
authors.forename: Andrew
authors.initials: A
authors.lastname: Pridmore
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001424:Bacterial Infections / Q000382:microbiology / Q000662:veterinary; D002371:Cat Diseases / Q000382:microbiology*; D002415:Cats; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D024841:Fluoroquinolones / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C507250:pradofloxacin