A one-step fusion of 1,3-thiazine and pyrimidine cycles.
The chlorotrimethylsilane-promoted Biginelli type reactions of aldehydes, thiourea, and cyanoketones led to a diverse set of tetrahydropyrimidine-2(1H)-thiones. Under similar conditions, thioureas, benzaldehyde, and cyanoacetamide reacted to give first representatives of hexahydro-5H-pyrimido[5,4-e][1,3]thiazin-5-ones in high preparative yield.
Ryabukhin
Sergey V
SV
Enamine Ltd., 23 A. Matrosova st., 01103 Kyiv, Ukraine. ryabukhin@mail.enamine.net
Plaskon
Andrey S
AS
Ostapchuk
Eugeniy N
EN
Volochnyuk
Dmitriy M
DM
Shishkin
Oleg V
OV
Shivanyuk
Alexander N
AN
Tolmachev
Andrey A
AA