Human subinsular asymmetry studied by diffusion tensor imaging and fiber tracking.
OBJECTIVE
Our aim was to improve our understanding of the subinsular white matter microstructural asymmetries in healthy right-handed subjects. Structural brain asymmetries could be related to functional asymmetries such as hemisphere language dominance or handedness. Besides the known gray matter asymmetries, white matter asymmetries could also play a key role in the understanding of hemispheric specialization, notably that of language.


METHODS
White matter asymmetries were studied by diffusion tensor imaging at 1.5T (41 diffusion-gradient directions; b-value set to 700 s/mm(2); matrix, 128(2); in-plane resolution, 1.875 x 1.875 mm; section thickness, 2.0 mm) and fiber tracking (BrainVISA software). The main white matter bundles passing through the subinsular area were segmented, and fractional anisotropy (FA) was measured along each of the segmented bundles.


RESULTS
In line with published results, we found an asymmetry of the arcuate fasciculus and the subinsular white matter, namely left-greater-than-right FA in right-handed controls. Furthermore, by segmenting major tracts coursing through this region, we showed that the subinsular portions of the uncinate fasciculus (UF) and the inferior occipitofrontal fasciculus (IOF) contribute to this FA asymmetry. Those tracts have been reported to be likely implicated in the language network.


CONCLUSIONS
Because the left hemisphere hosts language functions in most right-handers, the significant leftward asymmetry observed within the arcuate fasciculus, the subinsular part of the UF and IOF may be related to the hemispheric specialization for language.
Rodrigo
S
S
Département d'Imagerie Morphologique et Fonctionnelle, Faculté de Médecine, Université Paris-Descartes, Centre Hospitalier Sainte-Anne, Paris, France.
Naggara
O
O
Oppenheim
C
C
Golestani
N
N
Poupon
C
C
Cointepas
Y
Y
Mangin
J F
JF
Le Bihan
D
D
Meder
J F
JF
D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D002540:Cerebral Cortex; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D012016:Reference Values