Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea.
Many patients with rosacea are unable to tolerate extended treatment periods with topical agents because of the unusually high skin sensitivity that often accompanies rosacea. Kinetin (N(6)-furfuryladenine) is a plant cytokinin that reportedly helps restore skin barrier function and may be useful to ameliorate the signs and symptoms of rosacea. The purpose of this open-label study was to determine the tolerance and efficacy of twice-daily application of kinetin 0.1% lotion for improving the signs and symptoms of mild to moderate facial rosacea. Subjects applied kinetin 0.1% lotion twice daily to the face, with daily use of a sunscreen of sun protection factor 30. Subjects were evaluated at baseline and at 4-week intervals for 12 weeks to assess efficacy and tolerance. Results of this study suggest that kinetin 0.1% lotion is a well-tolerated moisturizing lotion option for subjects with mild to moderate inflammatory rosacea.
Wu
J J
JJ
Department of Dermatology, University of California, Irvine, Irvine, CA 92697-2400, USA. jjwu@uci.edu
Weinstein
G D
GD
Kricorian
G J
GJ
Kormeili
T
T
McCullough
J L
JL
D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D003879:Dermatologic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004643:Emollients / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007701:Kinetin / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012393:Rosacea / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index; D016896:Treatment Outcome
D003879:Dermatologic Agents; D004643:Emollients; D007701:Kinetin