[Human herpesvirus 6 encephalitis in a patient with adult T-cell leukemia/lymphoma].
Human herpesvirus 6 (HHV-6) reactivates in immunocompromised patients, and HHV-6 encephalitis has often been reported as a complication of transplantation. We describe a 37-year-old woman with the acute type of adult T-cell leukemia/lymphoma who developed HHV-6 encephalitis before chemotherapy. The patient's main symptoms were disorientation and short-term memory loss. Magnetic resonance imaging of the brain showed a bilateral T2 prolongation within the temporal lobes, and HHV-6 DNA was detected in the cerebrospinal fluid (CSF). After treatment with ganciclovir, HHV-6 DNA disappeared from the CSF and the patient's symptoms gradually improved. HHV-6 encephalitis should be listed as a differential diagnosis of encephalopathy developing in immunocompromised patients.
Idutsu
Kensaku
K
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University.
Abe
Yasunobu
Y
Otonari
Jun
J
Tachikawa
Yoshimichi
Y
Ohtsuka
Rie
R
Choi
Ilseung
I
Muta
Koichiro
K
Takayanagi
Ryoichi
R
D000328:Adult; D020803:Encephalitis, Herpes Simplex / Q000150:complications*; D005260:Female; D015654:Herpesvirus 6, Human; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications*; D009894:Opportunistic Infections / Q000150:complications*; D019349:Roseolovirus Infections / Q000150:complications*