ESR, electrochemical and reactivity studies of antitrypanosomal palladium thiosemicarbazone complexes.
Cyclic voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of novel palladium complexes with bioactive thiosemicarbazones derived from 5-nitrofurane or 5-nitrofurylacroleine. Sixteen palladium complexes grouped in two series of the formula [PdCl(2)HL] or [PdL(2)] were studied. ESR spectra of the free radicals obtained by electrolytic reduction were characterized and analyzed. The ESR spectra showed two different hyperfine patterns. The stoichiometry of the complexes does not seem to affect significantly the hyperfine constants however we observed great differences between 5-nitrofurane and 5-nitrofurylacroleine derivatives. The scavenger properties of this family of compounds were lower than Trolox.
Otero
Lucía
L
Cátedra de Química Inorgánica, DEC, Facultad de Química, UdelaR, Montevideo, Uruguay.
Folch
Christian
C
Barriga
Germán
G
Rigol
Carolina
C
Opazo
Lucia
L
Vieites
Marisol
M
Gambino
Dinorah
D
Cerecetto
Hugo
H
Norambuena
Ester
E
Olea-Azar
Claudio
C
D002839:Chromans / Q000737:chemistry; D004563:Electrochemistry; D004578:Electron Spin Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry*
D002839:Chromans; D013882:Thiosemicarbazones; D014344:Trypanocidal Agents; D010165:Palladium; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid