title: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by vinorelbine treatment of metastatic breast cancer.
abstract: BACKGROUND
  Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is known as a rare adverse event with chemotherapy. We report the case of a SIADH occurring after vinorelbine treatment.
  
  
  METHODS
  In a 79-year-old woman breast cancer was first diagnosed in 2000. Three years after the first diagnosis the patient developed bone and liver metastases. Seven days after receiving the 1st course of palliative chemotherapy with vinorelbine the patient suffered from decreased mental awareness, fatigue, and physical weakness. After the diagnosis of SIADH based on laboratory findings in combination with clinical symptoms, we started therapy with balanced fluid intake and intravenous infusion of normotonic saline.
  
  
  CONCLUSIONS
  The development of SIADH as a rare adverse event with vinorelbine treatment has to be taken into consideration.
authors.affiliation: Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus Dresden, Germany. ulrich.canzler@uniklinikum-dresden.de
authors.forename: Ulrich
authors.initials: U
authors.lastname: Canzler
authors.forename: Uta Katharina
authors.initials: UK
authors.lastname: Schmidt-Göhrich
authors.forename: Sybille
authors.initials: S
authors.lastname: Bergmann
authors.forename: Katrin
authors.initials: K
authors.lastname: Hänseroth
authors.forename: Axel
authors.initials: A
authors.lastname: Gatzweiler
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Distler
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000556:secondary; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000517:prevention & control*; D008875:Middle Aged; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D000077235:Vinorelbine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine