title: Treatment of high output entero-cutaneous fistulae associated with large abdominal wall defects: single center experience.
abstract: OBJECTIVE
  Enteric fistulas are defined by their sites of origin, communication and flow. We evaluate the treatment of complex patients with entero-cutaneous fistulae with large abdominal wall defects.
  
  
  METHODS
  Retrospective case note review of 19 patients (15 males, median age 46 years) treated at the Department of Surgical Sciences, University of Insubria, Varese, Italy. These were distinguished by multiple/wide gastrointestinal fistula orifices, with total discontinuity of bowel. Fistulas were not covered by abdominal wall thus presenting with a giant abdominal wall defects. Surgery was planned once adequate nutritional status was present.
  
  
  RESULTS
  All fistulas resulted from previous surgery for IBD in 7 cases (37%), abdominal trauma 4 (21%), acute necrotic infected pancreatitis 3 (16%), intra-abdominal malignancy 3 (16%), and diverticular disease 2 (10%). The most common site of presentation was ileum (80%). Median fistula output was 800ml/day (range 400-1600ml/day). Seltzer's prognostic index identified malnutrition in 70% of patients at the time of presentation. The elapsed mean time from onset of fistula and elective time of surgical management were 184 days (range 20-2190 days). The VAC system was used in the last 7 patients preoperatively and in 6 patients with postoperative abdominal wound dehiscences that could not be closed immediately and who were at high risk for healing complications. There were no complications from the VAC therapy. Surgery was successful in 69% of cases. Mortality rate was 21%. Factors related to mortality were persistent malignancy, malnutrition and sepsis.
  
  
  CONCLUSIONS
  After optimization of nutritional status surgery with en bloc resection of fistula offers best results. In this series, cancer and sepsis were unfavourable factors for outcome. These fistulas may be successfully managed with a multidisciplinary approach.
authors.affiliation: Department of Surgical Sciences, University of Insubria, Viale Borri 57, 21100 Varese, Italy. gianlorenzo.dionigi@uninsubria.it
authors.forename: G
authors.initials: G
authors.lastname: Dionigi
authors.forename: R
authors.initials: R
authors.lastname: Dionigi
authors.forename: F
authors.initials: F
authors.lastname: Rovera
authors.forename: L
authors.initials: L
authors.lastname: Boni
authors.forename: P
authors.initials: P
authors.lastname: Padalino
authors.forename: G
authors.initials: G
authors.lastname: Minoja
authors.forename: S
authors.initials: S
authors.lastname: Cuffari
authors.forename: G
authors.initials: G
authors.lastname: Carrafiello
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007412:Intestinal Fistula / Q000150:complications / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy; D009752:Nutritional Status; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D016038:Skin Transplantation; D013526:Surgical Mesh; D013529:Surgical Wound Dehiscence / Q000150:complications / Q000601:surgery*