title: Hypotheses, tests, methods, and innovation: the balancing act in research.
abstract: Clinical and epidemiological research studies are essential to advancing our understanding of human health conditions such as epilepsy. To be of value, studies must not only address important questions, they must do so in such a way as to contribute usefully to existing knowledge. Comprehensive understanding of the subject matter is only one component of successful research and research reports. A firm grasp of research methods and statistical issues and a scholarly command of the relevant and current literature are essential components to high-quality research. No single study, however, is perfect nor can any single study definitively answer a given single research question. Studies must be designed and evaluated in light of historical, scientific, pragmatic, and ethical realities that may constrain them. Selected but essential methodological and statistical concepts are discussed along with the need to balance innovation and novelty against methodological rigor.
authors.affiliation: Department of Biology, NIU, DeKalb, IL 60115, USA. atberg@niu.edu
authors.forename: Anne T
authors.initials: AT
authors.lastname: Berg
mesh_terms: D015982:Bias; D003625:Data Collection; D003627:Data Interpretation, Statistical; D016021:Epidemiologic Studies; D004827:Epilepsy; D032984:Ethics, Research; D006801:Humans; D012106:Research / Q000458:organization & administration* / Q000592:standards; D012107:Research Design