title: A new isocoumarin from Hypericum annulatum.
abstract: A new isocoumarin, annulatomarin (1), together with the known physcion and beta-sitosterol were isolated from the aerial parts of Hypericum annulatum. The structure of the new compound was established as 6,8-dihydroxy-7-methoxy-3-phenyl-3,4-dihydro-1H-isochromen-1-one on the basis of detailed spectroscopic analysis. Annulatomarin exhibited a modest growth-inhibitory activity in vitro against human chronic myeloid leukaemia LAMA-84 cells with an IC(50) = 111 microM.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria. pnedialkov@pharmfac.net
authors.forename: Paraskev T
authors.initials: PT
authors.lastname: Nedialkov
authors.forename: Dimitrina
authors.initials: D
authors.lastname: Zheleva-Dimitrova
authors.forename: Ulrich
authors.initials: U
authors.lastname: Girreser
authors.forename: Gerassim M
authors.initials: GM
authors.lastname: Kitanov
mesh_terms: D045744:Cell Line, Tumor; D004642:Emodin / Q000031:analogs & derivatives / Q000737:chemistry; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D049934:Isocoumarins / Q000737:chemistry*; D008967:Molecular Biology; D012855:Sitosterols / Q000737:chemistry
chemical_list: D049934:Isocoumarins; D012855:Sitosterols; C525227:annulatomarin; C025473:gamma-sitosterol; C008905:physcione; D004642:Emodin