title: Cascade coupling/cyclization process to N-substituted 1,3-dihydrobenzimidazol-2-ones.
abstract: Assembly of N-substituted 1,3-dihydrobenzimidazol-2-ones is achieved starting from methyl o-haloarylcarbamates via a CuI/amino acid catalyzed coupling with amines and subsequent condensative cyclization. A number of functional groups are tolerated by these reaction conditions, including vinyl, nitro, carboxylate, amide, ester, ketone, and silyl ether groups.
authors.affiliation: Department of Chemistry, Fudan University, Shanghai 200433, China.
authors.forename: Benli
authors.initials: B
authors.lastname: Zou
authors.forename: Qiliang
authors.initials: Q
authors.lastname: Yuan
authors.forename: Dawei
authors.initials: D
authors.lastname: Ma
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure
chemical_list: D001562:Benzimidazoles