title: Preparation and antitubercular activities of alkylated amino alcohols and their glycosylated derivatives.
abstract: A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5mug/mL. The presence of the carbohydrate slightly affected the antibacterial activity.
authors.affiliation: Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora-MG 36036-330, Brazil.
authors.forename: Aline F
authors.initials: AF
authors.lastname: Taveira
authors.forename: Mireille Le
authors.initials: ML
authors.lastname: Hyaric
authors.forename: Elaine F C
authors.initials: EF
authors.lastname: Reis
authors.forename: Débora P
authors.initials: DP
authors.lastname: Araújo
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Ferreira
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: de Souza
authors.forename: Lívia L
authors.initials: LL
authors.lastname: Alves
authors.forename: Maria C S
authors.initials: MC
authors.lastname: Lourenço
authors.forename: Felipe Rodrigues C
authors.initials: FR
authors.lastname: Vicente
authors.forename: Mauro V
authors.initials: MV
authors.lastname: de Almeida
mesh_terms: D000478:Alkylation; D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation; D002478:Cells, Cultured; D006031:Glycosylation; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000605:Amino Alcohols; D000995:Antitubercular Agents