title: Long-term results of surgical treatment for recurrent respiratory papillomatosis.
abstract: CONCLUSIONS
  The presented results add further support to the observation that laser microsurgery is the preferential surgical treatment for recurrent respiratory papillomatosis (RRP). A meticulous follow-up for early recognition of local recurrence and malignant transformation is recommended.
  
  
  OBJECTIVE
  Endoscopic microsurgery continues to be the treatment of choice for RRP. The aim of this study was to evaluate the outcome of patients treated surgically. We focused on demographic data, recurrence rates, and treatment-related complications.
  
  
  METHODS
  The charts of 194 patients treated at our institution between 1963 and 1993 were analyzed retrospectively.
  
  
  RESULTS
  In all, 64 patients (33%) underwent a total of 137 operations using the CO2 laser; 130 patients (67%) underwent a total of 565 microlaryngeal operations by surgery with cold instruments. Five percent of the patients treated with conventional microlaryngeal surgery and none of the patients treated with laser surgery required tracheostomy (p<0.05). Postoperative glottic webs and scar formations were found in 6% of all patients after laser surgery and 20% after conventional surgery (p<0.05). The different methods of treatment did not affect the rate of recurrence (p=0.61) Malignant transformation or secondary airway carcinoma were observed in 4% of all patients.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Josef Stelzmann Str. 9, 50924 Cologne, Germany. simon.preuss@uni-koeln.de
authors.forename: Simon Florian
authors.initials: SF
authors.lastname: Preuss
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Klussmann
authors.forename: Markus
authors.initials: M
authors.lastname: Jungehulsing
authors.forename: Hans Edmund
authors.initials: HE
authors.lastname: Eckel
authors.forename: Orlando
authors.initials: O
authors.lastname: Guntinas-Lichius
authors.forename: Michael
authors.initials: M
authors.lastname: Damm
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D007828:Laryngoscopy / Q000379:methods*; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010212:Papilloma / Q000601:surgery*; D012189:Retrospective Studies; D013997:Time Factors; D014139:Tracheostomy; D016896:Treatment Outcome