[Lipid profile in untreated HIV positive patients. HIV infection: cardiovascular risk factor?].
BACKGROUND
Some cases of HIV+ patients with unexplained vascular disease have been reported and many studies are being performed to determine whether HIV infected individuals have an increased cardio-vascular risk (CVR). We propose: to describe lipid profile of untreated HIV+ patients and to compare it with the HIV- and to assess whether any of the lipid abnormalities influence in CVR estimation.


METHODS
407 homosexual males: 251 untreated HIV+ and 156 HIV-. Biochemistry parameters: Total cholesterol (CHOL), HDL-cholesterol (HDL), VLDL-cholesterol, LDL-cholesterol (LDL), triglycerides (TG), apolipoproteins A1 and B (ApoA1 y ApoB) and lipoprotein A. Atherogenic rates: CHOL/HDL, LDL/HDL and log (TG/HDL). HIV+ patients were classified into three groups according to CD4 lymphocytes number.


RESULTS
HIV+ patients had lower CHOL, HDL, and ApoA1 and higher CVR rates. These differences showed also between each HIV+ group according to CD4 number and control group HIV-. 76% of the HIV+ patients showed low levels of HDL (less than 40 mg/dL) as compared with 31% of HIV- subjects.


CONCLUSIONS
Untreated HIV+ patients' lipid profile is different from the HIV- subjects; one. There are decreases in HDL and ApoA1 from the beginning of the infection that persis along all the CD4 levels. HDL decrease in HIV infection multiplies global CVR in HIV infected individuals, independently of other risk factors.
Baza Caraciolo
B
B
Centro Sanitario Sandoval, IMSALUD Area 7 de la Comunidad de Madrid, Madrid, Spain. begobaza@gmail.com
Pérez de Oteyza
C
C
Carrió Montiel
D
D
Carrió Montiel
J C
JC
Salguero Aparicio
M
M
Del Romero Guerrero
J
J
D000328:Adult; D018791:CD4 Lymphocyte Count; D002318:Cardiovascular Diseases / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003627:Data Interpretation, Statistical; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000097:blood*; D018451:Homosexuality, Male; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol