title: [Effects of Astragalus on expression of renal angiopoietin receptor Tie-2 in diabetic rats].
abstract: OBJECTIVE
  To study the expression of angiopoietin receptor Tie-2 in the renal tissue of diabetic rats and the effects of Astragalus.
  
  
  METHODS
  SD rats were randomly divided into normal control group, diabetes group and Astragalus-treated group. The expression of receptor Tie-2 in the renal tissue was assessed by using real-time quantitative polymerase chain reaction and immunohistochemical method.
  
  
  RESULTS
  Glomerule Tie-2 protein expression was significantly elevated in the diabetes group as compared with the normal control group (P<0.01). Glomerule Tie-2 protein expression in the Astragalus-treated group was decreased as compared with the diabetes group (P<0.01).
  
  
  CONCLUSIONS
  Tie-2 may play an important role in the pathogenesis of the early stage diabetic renal injury. The reno-protection effect of Astragalus may be mediated by down-regulating the expression of Tie-2 in the kidney tissue of diabetic rats.
authors.affiliation: Department of Nephrology, Renji Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200127, China.
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Gu
authors.forename: Zhao-hui
authors.initials: ZH
authors.lastname: Ni
authors.forename: Le-yi
authors.initials: LY
authors.lastname: Gu
authors.forename: Yu-cheng
authors.initials: YC
authors.lastname: Yan
authors.forename: Hui-li
authors.initials: HL
authors.lastname: Dai
authors.forename: Ning-li
authors.initials: NL
authors.lastname: Li
authors.forename: Min-fang
authors.initials: MF
authors.lastname: Zhang
authors.forename: Jia-qi
authors.initials: JQ
authors.lastname: Qian
mesh_terms: D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000473:pathology; D003928:Diabetic Nephropathies / Q000378:metabolism; D015536:Down-Regulation; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D042787:Receptor, TIE-2 / Q000378:metabolism*
chemical_list: D010936:Plant Extracts; D042787:Receptor, TIE-2