New biologically active epidioxysterols from Stereum hirsutum.
From the fungus Stereum hirsutum have been isolated and identified two new epidioxysterols 1, 4, together with two known ones 2 and 3. Their structures were elucidated on the basis of spectroscopic analysis and chemical reactions. Epidioxysterols 1-4 have been shown to possess a significant activity against Mycobacterium tuberculosis.
Cateni
Francesca
F
Department of Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, Trieste, Italy. cateni@units.it
Doljak
Bojan
B
Zacchigna
Marina
M
Anderluh
Marko
M
Piltaver
Andrej
A
Scialino
Giuditta
G
Banfi
Elena
E
D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D002788:Cholesterol Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
D000995:Antitubercular Agents; D002788:Cholesterol Esters; C421424:epidioxysterol