title: Adhesion molecules as prognostic markers in pancreatic adenocarcinoma.
abstract: OBJECTIVE
  Pancreatic adenocarcinoma is a highly aggressive cancer with high metastatic potential and therefore, a high mortality rate. Ezrin, radixin, moesin, and E-cadherin are transmembrane glycoproteins that regulate cell motility, migration, and metastasis. In this study, we investigated the relationship of ezrin, moesin, and E-cadherin expression with the clinicopathological features of pancreatic ductal adenocarcinoma.
  
  
  METHODS
  Data including demographic features, size and grade of tumor, presence of perineural and lymphovascular invasion, and survival were obtained retrospectively from 46 patient records.
  
  
  RESULTS
  No significant correlation was found among ezrin, moesin, and E-cadherin. Significant correlations were found between ezrin and the tomographic size of the tumor (P = 0.034) and resectability (P = 0.052). Moesin-stained tumors were found to have high lymphovascular (P = 0.030) and perineural (P = 0.036) invasion rates and a high histopathologic grade (P = 0.053). E-cadherin staining was correlated with perineural invasion (P = 0.003) but not with lymphovascular invasion (P = 0.334). Only moesin was correlated with survival in resected pancreatic adenocarcinomas and moesin-negative patients had longer survivals compared with moesin-positive patients (P = 0.021).
  
  
  CONCLUSIONS
  We could not demonstrate a relation between ezrin and E-cadherin staining with survival. However, we found ezrin to be related to local tumor behavior, and moesin to be a potential prognostic molecule.
authors.affiliation: Department of General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey. ntorer@baskent-adn.edu.tr
authors.forename: Nurkan
authors.initials: N
authors.lastname: Torer
authors.forename: Fazilet
authors.initials: F
authors.lastname: Kayaselcuk
authors.forename: Tarik Zafer
authors.initials: TZ
authors.lastname: Nursal
authors.forename: Sedat
authors.initials: S
authors.lastname: Yildirim
authors.forename: Akin
authors.initials: A
authors.lastname: Tarim
authors.forename: Turgut
authors.initials: T
authors.lastname: Nòyan
authors.forename: Hamdi
authors.initials: H
authors.lastname: Karakayali
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D015820:Cadherins; D003598:Cytoskeletal Proteins