Childhood pustular psoriasis associated with Panton-Valentine leukocidin-producing Staphylococcus aureus.
We report the association of a generalized pustular psoriasis and infection by Staphylococcus aureus which produced Panton-Valentine leukocidin in a 5-year-old child. Another S. aureus strain with the same toxin gene content was also isolated among three family members presenting with cutaneous lesions. Although a methicillin-resistant staphylococcal strain has been reported in association with pustular psoriasis, this is the first report of a Panton-Valentine leukocidin strain associated with generalized pustular psoriasis. The causal relationship between S. aureus produced Panton-Valentine leukocidin and skin lesions is discussed.
Pouessel
Guillaume
G
Department of Paediatrics, Victor Provo Hospital, Roubaix, France. guillaume.pouessel@ch-roubaix.fr
Ythier
Hubert
H
Carpentier
Olivier
O
Vachée
Anne
A
Etienne
Jerome
J
Catteau
Benoit
B
D001427:Bacterial Toxins; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000382:microbiology; D005098:Exotoxins; D005260:Female; D006801:Humans; D007956:Leukocidins; D016106:Methicillin Resistance; D011565:Psoriasis / Q000382:microbiology*; D013207:Staphylococcal Skin Infections / Q000150:complications*; D013211:Staphylococcus aureus / Q000302:isolation & purification*
D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin