Radiographic evaluation of children with growth disorders.
Short stature as well as tall stature can have a wide variety of causes. Tall stature is usually experienced as a less important problem than short stature, but for both clinical presentations it is important to make a correct diagnosis as to etiology. The identification of the diagnosis frequently relies on radiological criteria. However, no international uniformity exists with respect to the radiographic evaluation of children with growth problems. We recommend that in patients with a possible diagnosis of a skeletal dysplasia a skeletal survey must be performed. In patients with a proportionate stature, radiographic analysis of the hand and wrist will be sufficient in most cases. However, whenever there are clinical abnormalities with a possible underlying bone anomaly, a modified skeletal survey is appropriate. The combination of clinical and biochemical features and an appropriate skeletal survey can often lead to the correct diagnosis and/or guide the subsequent molecular analysis.
Kant
S G
SG
Center for Human and Clinical Genetics, Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. s.g.kant@lumc.nl
Grote
F
F
de Ru
M H
MH
Oostdijk
W
W
Zonderland
H M
HM
Breuning
M H
MH
Wit
J M
JM
D001175:Arthrography / Q000379:methods* / Q000592:standards*; D001827:Body Height; D002648:Child; D006130:Growth Disorders / Q000000981:diagnostic imaging*; D006801:Humans; D017410:Practice Guidelines as Topic