title: Target-specific and global effectors in gene regulation by MicroRNA.
abstract: MicroRNAs are responsible for post-transcriptional gene silencing as part of critical cellular pathways and intercellular coordination, for example during embryonic development. Yet, the basic mechanism by which this silencing is accomplished is still not understood. For example, it is not known to what extent and through what process does the suppression of protein accumulation accompany a reduction in mRNA level. Here we present a simple quantitative modeling approach to microRNA mediated silencing. We show how differential responses of the mRNA- and protein levels may be tuned by target-specific parameters and how global effectors may alter this behavior for some-but not all-miRNA targets in the cell.
authors.affiliation: Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California, USA. elevine@ucsd.edu
authors.forename: Erel
authors.initials: E
authors.lastname: Levine
authors.forename: Eshel
authors.initials: E
authors.lastname: Ben Jacob
authors.forename: Herbert
authors.initials: H
authors.lastname: Levine
mesh_terms: D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000235:genetics*; D020868:Gene Silencing / Q000502:physiology*; D035683:MicroRNAs / Q000235:genetics*; D008957:Models, Genetic; D014176:Protein Biosynthesis / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*
chemical_list: D035683:MicroRNAs