title: A review of the efficacy of human Q fever vaccine registered in Australia.
abstract: BACKGROUND
  Q fever remains an important occupational zoonosis in rural Australia. Although Q fever vaccine is recommended in high-risk occupational groups, its availability has been limited in recent years.
  
  
  METHODS
  A literature review of the efficacy of the human Q fever vaccine registered in Australia was conducted.
  
  
  RESULTS
  Seven relevant vaccine efficacy studies were identified but no large double-blind, randomised, placebo-controlled studies have been conducted. Vaccine efficacy has ranged from 83-100% but limitations of study designs hamper a precise estimate of vaccine efficacy.
  
  
  CONCLUSIONS
  Despite the shortcomings of efficacy studies, the Q fever vaccine available in Australia has considerable protective benefit in established high-risk environments, particularly of an occupational nature.
authors.affiliation: NSW Public Health Officer Training Program, NSW Department of Health, Australia.
authors.forename: Clayton K
authors.initials: CK
authors.lastname: Chiu
authors.forename: David N
authors.initials: DN
authors.lastname: Durrheim
mesh_terms: D000818:Animals; D001315:Australia; D001428:Bacterial Vaccines / Q000494:pharmacology*; D003381:Coxiella / Q000276:immunology*; D016997:Coxiella burnetii / Q000276:immunology*; D006801:Humans; D017589:Immunization Programs; D016272:Occupational Health; D011778:Q Fever / Q000276:immunology / Q000517:prevention & control*; D018570:Risk Assessment; D012424:Rural Population; D015047:Zoonoses
chemical_list: D001428:Bacterial Vaccines