title: The first organocatalytic carbonyl-ene reaction: isomerisation-free C-C bond formations catalysed by H-bonding thio-ureas.
abstract: Intramolecular carbonyl ene reactions of highly activated enophiles can be catalysed by H-bonding thio-ureas to give tertiary alcohols in high yields without extensive isomerisation side products. An asymmetric variant of this reaction was realised using a chiral thiourea but was limited by low enantioselectivity (up to 33% e.e.) and low turnover frequencies.
authors.affiliation: School of Chemistry, University of St, Andrews, EaStCHEM, St, Andrews, Fife, KY16 9ST, UK. mc28@st-andrews.ac.uk
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Clarke
authors.forename: Charlotte E S
authors.initials: CE
authors.lastname: Jones
authors.forename: Marcia B
authors.initials: MB
authors.lastname: France