title: Approximate analytical time-dependent solutions to describe large-amplitude local calcium transients in the presence of buffers.
abstract: Local Ca(2+) signaling controls many neuronal functions, which is often achieved through spatial localization of Ca(2+) signals. These nanodomains are formed due to combined effects of Ca(2+) diffusion and binding to the cytoplasmic buffers. In this article we derived simple analytical expressions to describe Ca(2+) diffusion in the presence of mobile and immobile buffers. A nonlinear character of the reaction-diffusion problem was circumvented by introducing a logarithmic approximation of the concentration term. The obtained formulas reproduce free Ca(2+) levels up to 50 microM and their changes in the millisecond range. Derived equations can be useful to predict spatiotemporal profiles of large-amplitude [Ca(2+)] transients, which participate in various physiological processes.
authors.affiliation: DFG-Center of Molecular Physiology of the Brain, Department of Neuro- and Sensory Physiology, Georg-August-University, Göttingen, Germany.
authors.forename: Lidia A
authors.initials: LA
authors.lastname: Mironova
authors.forename: Sergej L
authors.initials: SL
authors.lastname: Mironov
mesh_terms: D002021:Buffers; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D003593:Cytoplasm / Q000378:metabolism; D004058:Diffusion; D004533:Egtazic Acid; D007700:Kinetics; D013997:Time Factors
chemical_list: D002021:Buffers; D004533:Egtazic Acid; D002118:Calcium