title: Inhibitors of NF-kappaB derived from thalidomide.
abstract: A series of compounds originally derived from thalidomide were synthesized and evaluated. The most potent compounds in this series, 5HPP-33 and compound 20, inhibited NF-kappaB activation in HeLa cells. Preliminary study indicated that the mechanism of inhibition of NF-kappaB activation is through inhibition of its translocation from the cytoplasm to the nucleus.
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Esperanza J Carcache
authors.initials: EJ
authors.lastname: de-Blanco
authors.forename: Bulbul
authors.initials: B
authors.lastname: Pandit
authors.forename: Zhigen
authors.initials: Z
authors.lastname: Hu
authors.forename: Jiandong
authors.initials: J
authors.lastname: Shi
authors.forename: Andrew
authors.initials: A
authors.lastname: Lewis
authors.forename: Pui-Kai
authors.initials: PK
authors.lastname: Li
mesh_terms: D006367:HeLa Cells; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D013792:Thalidomide / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D016328:NF-kappa B; D013792:Thalidomide