Glucose tolerance abnormalities in Australian women with polycystic ovary syndrome.
OBJECTIVE
To determine the prevalence of glucose tolerance abnormalities and to identify associated risk factors in women with polycystic ovary syndrome (PCOS) attending a reproductive endocrinology clinic.


METHODS
Retrospective chart review.


METHODS
372 women with confirmed PCOS attending a reproductive endocrinology clinic at Adelaide University's Research Centre for Reproductive Health.


METHODS
Prevalence of glucose tolerance abnormalities and association of such abnormalities with potential risk factors.


RESULTS
4.0% (15 women) had diabetes mellitus, 15.6% (58) had impaired glucose tolerance and 80.4% (299) had normal glucose tolerance. There was a significant trend towards increasing prevalence of diabetes with increasing age (odds ratio [OR], 0.60; P = 0.0085). The prevalence of abnormal glucose tolerance (diabetes and impaired glucose tolerance together) was significantly higher with higher waist circumference (OR, 2.9; P = 0.05), higher body mass index (OR, 8.02; P = 0.0253), a family history of diabetes (OR, 1.56; P = 0.0192) and the presence of metabolic syndrome (OR, 5.62; P < 0.001).


CONCLUSIONS
The prevalence of diabetes and impaired glucose tolerance is high in women with PCOS, especially in older women and those with abdominal obesity and a family history of diabetes.
Dabadghao
Preeti
P
Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA, Australia.
Roberts
Bronwen J
BJ
Wang
Jim
J
Davies
Michael J
MJ
Norman
Robert J
RJ
D000293:Adolescent; D000328:Adult; D048909:Diabetes Complications; D005260:Female; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000150:complications; D005951:Glucose Tolerance Test; D006801:Humans; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D012189:Retrospective Studies
D005947:Glucose