Novel application of Leuckart-Wallach reaction for synthesis of tetrahydro-1,4-benzodiazepin-5-ones library.
A novel and efficient strategy has been developed to synthesize privileged tetrahydro-1,4-benzodiazepines with excellent yields and purities; this synthetic pathway was established by the revitalization of the Leuckart-Wallach (LW) reaction via solid-phase synthesis.
Lee
Sung-Chan
SC
Department of Chemistry, Seoul National University, Seoul 151-747, Korea.
Park
Seung Bum
SB
D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure
D001569:Benzodiazepines