Acylated flavone glycosides from the roots of Saussurea lappa and their antifungal activity.
The isolation of four novel acylated flavonoid glycosides from the roots of Saussurea lappa and their identification using a combination of 1D and 2D NMR and mass spectrometry is described. The in vitro antifungal and antibacterial activities of the isolated compounds and their mixture were tested on nine fungal and four bacterial strains, using the microdilution method. The compounds and mixture showed moderate to high antifungal activity against most of the fungi tested, compared to a miconazole standard, while only one compound and the mixture showed antibacterial activity against all strains tested.
Rao
Kolisetty Sambasiva
KS
School of Studies in Chemistry, Vikram University, Ujjain 456010, M.P. India. ksrao7709@rediffmail.com
Babu
Goriparthi Venu
GV
Ramnareddy
Yemireddy Venkata
YV
D000215:Acylation; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002247:Carbon Isotopes; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification*; D005658:Fungi / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry*; D011522:Protons; D030441:Saussurea / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000935:Antifungal Agents; D002247:Carbon Isotopes; D047309:Flavones; D006027:Glycosides; D011522:Protons