Lipopolysaccharide-induced neutrophilic inflammation in the lungs differs with age.
In aged humans and animals, lung injuries are generally more serious and prolonged. From a kinetic perspective, the authors thus assessed whether lung expression of proinflammatory cytokines were altered with age following intratracheal lipopolysaccharide (LPS) challenge in mice. Tumor necrosis factor-alpha, interleukin-1beta, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-2, and keratinocyte-derived chemokine were significantly higher in 65-week-old mice along with sustained neutrophilia when compared to 11-week-old mice at 72 hours, but not at earlier time points. The authors concluded that the degree of LPS-induced neutrophilic inflammation and the expression of these cytokines differ with age at later phases of acute lung injury.
Ito
Yoko
Y
First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Betsuyaku
Tomoko
T
Nasuhara
Yasuyuki
Y
Nishimura
Masaharu
M
D000375:Aging / Q000276:immunology*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D018450:Disease Progression; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity*; D008168:Lung / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D020556:Neutrophil Infiltration / Q000187:drug effects; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000276:immunology*
D016207:Cytokines; D008070:Lipopolysaccharides