title: N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors.
abstract: Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.
authors.affiliation: Institute of Pharmacy, Leopold-Franzens University of Innsbruck, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Rakowitz
authors.forename: A
authors.initials: A
authors.lastname: Gmeiner
authors.forename: B
authors.initials: B
authors.lastname: Matuszczak
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002417:Cattle; D004121:Dimethyl Sulfoxide; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000085:Acetates; D004791:Enzyme Inhibitors; D011799:Quinazolines; D012997:Solvents; D000449:Aldehyde Reductase; D004121:Dimethyl Sulfoxide