Eremophilane-type sesquiterpenes from Senecio nemorensis.
Three new highly oxygenated eremophilane-type sesquiterpenes, 1 beta,10 beta(8,12)-diepoxy-7 beta,11 beta-dihydroxy-8 beta,12 alpha-dimethoxyeremophilane (1), 1 beta,10 beta-epoxy-7 beta-hydroxy-8 alpha-methoxyeremophil-11 alphaH-12,8 beta-olide (2), and 6 beta-isobutyryloxy-8 alpha-hydroxy-1-oxoeremophil-7(11),9-dien-12,8 beta-olide (3), together with nine known compounds (4-12) were isolated from the roots and aerial parts of Senecio nemorensis L. (Compositae). Structures of compounds 1-3 were elucidated on the basis of spectroscopic evidence including IR, HR-ESI-MS, 1D and 2D NMR techniques and were unequivocally confirmed by single-crystal X-ray diffraction experiments. The antimicrobial activity of the isolated compounds 1-3 and 8-12 was tested against Staphylococcus aureus and Candida albicans.
Fei
Dong-Qing
DQ
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
Zhang
Zhan-Xin
ZX
Chen
Jian-Jun
JJ
Gao
Kun
K
D002176:Candida albicans / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D012674:Senecio / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*
D012717:Sesquiterpenes