Amino-caprolactam derivatives as gamma-secretase inhibitors.
A series of amino-caprolactam sulfonamides were developed from a screening hit. Compounds with good in vitro and in vivo gamma-secretase activity are reported.
Parker
Michael F
MF
Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. parkerm@BMS.com
Bronson
Joanne J
JJ
Barten
Donna M
DM
Corsa
Jason A
JA
Du
Wengsheng
W
Felsenstein
Kevin M
KM
Guss
Valerie L
VL
Izzarelli
Darcy
D
Loo
Alice
A
McElhone
Kate E
KE
Marcin
Larry R
LR
Padmanabha
Ramesh
R
Pak
Roger
R
Polson
Craig T
CT
Toyn
Jeremy H
JH
Varma
Sam
S
Wang
Jian
J
Wong
Victoria
V
Zheng
Ming
M
Roberts
Susan B
SB
D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D002209:Caprolactam / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D002209:Caprolactam; D053829:Amyloid Precursor Protein Secretases