The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier association.
Recently, a single nucleotide polymorphism (SNP, rs1800206) in the peroxisome proliferator-activated receptor alpha (PPAR-alpha) gene has been proposed to be associated with Alzheimer's disease (AD). To verify this finding, we analyzed the PPAR-alpha SNP in 461 patients with AD and 1395 controls. In subgroups, PPAR-alpha gene data could be investigated in relation to biochemical and neuropathological markers for AD. We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD.
Sjölander
Annica
A
Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Göteborg University, Sweden. annica.johansson@clinchem.gu.se
Minthon
Lennart
L
Bogdanovic
Nenad
N
Wallin
Anders
A
Zetterberg
Henrik
H
Blennow
Kaj
K
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000235:genetics; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D047493:PPAR alpha / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D016875:tau Proteins / Q000235:genetics
D016229:Amyloid beta-Peptides; D005819:Genetic Markers; D047493:PPAR alpha; D016875:tau Proteins