title: Mucinous rectal adenocarcinoma can be associated to tumor downstaging after preoperative chemoradiotherapy.
abstract: OBJECTIVE
  The aim of this study was to evaluate downstaging as primary end point, and progression-free survival and overall survival as secondary end points, in rectal adenocarcinoma patients treated with preoperative chemoradiation.
  
  
  METHODS
  One hundred and thirty-six extraperitoneal adenocarcinoma patients (33 low rectum T2, 74 T3, 29 T4 [without sacral invasion], 25 with mucinous subtype) were treated with posterior pelvis preoperative radiotherapy (5040 cGy total dose, 180 cGy/fr, 5 fr/w, 10-15 MV linac X-rays) and concomitant 5-fluorouracil-based chemotherapy. After 6 to 8 weeks patients underwent surgery and prechemoradiation clinical stage was compared with pathologic stage to evaluate downstaging in each patient. Seventy-four patients received adjuvant chemotherapy. Median follow-up was 39 months (4-84).
  
  
  RESULTS
  Forty-four patients had macroscopic complete response, 52 patients had partial response, 37 patients showed no change and 3 patients had progression. At multivariate analysis only histotype showed correlation with downstaging (hazard ratio = 0.350 and 0.138 - 0.885 95 percent confidence interval) because of the evidence for poor downstaging in mucinous subtype. There were no significant differences in overall survival and progression-free survival between adenocarcinoma and mucinous subtype.
  
  
  CONCLUSIONS
  The main finding is that mucinous histology is associated with poor downstaging after preoperative chemoradiation but this poor response was not associated with worse outcome in this small study. The good outcome for mucinous histology is at odds with other reports in the literature and requires further study.
authors.affiliation: Dipartimento di Oncologia e Radioterapia Generale, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy. filippo.grillo.ruggieri@galliera.it
authors.forename: Filippo
authors.initials: F
authors.lastname: Grillo-Ruggieri
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mantello
authors.forename: Rossana
authors.initials: R
authors.lastname: Berardi
authors.forename: Massimo
authors.initials: M
authors.lastname: Cardinali
authors.forename: Francesco
authors.initials: F
authors.lastname: Fenu
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Iovini
authors.forename: Maria
authors.initials: M
authors.lastname: Montisci
authors.forename: Letizia
authors.initials: L
authors.lastname: Fabbietti
authors.forename: Cristina
authors.initials: C
authors.lastname: Marmorale
authors.forename: Mario
authors.initials: M
authors.lastname: Guerrieri
authors.forename: Vittorio
authors.initials: V
authors.lastname: Saba
authors.forename: Italo
authors.initials: I
authors.lastname: Bearzi
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Mattioli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bonsignori
authors.forename: Stefano
authors.initials: S
authors.lastname: Cascinu
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D013505:Digestive System Surgical Procedures; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D015996:Survival Rate
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil