title: [Analysis of complications of osteosarcoma around knee treated by resection and replacement of tumor-type prosthesis].
abstract: OBJECTIVE
  To summarize the effects and complications of osteosarcoma around knee treated by wide resection and replacement by the tumor-type prosthesis.
  
  
  METHODS
  Between July 1997 and July 2004, 117 patients with osteosarcoma around the knee had been treated with wide resection and reconstruction with prosthesis. Alcohol-devitalized tumor bone prosthetic composite were used for reconstruction in 13 patients, and allograft prosthetic composite (APC) were used in 25 patients. All patients accepted 2 cycles of chemotherapy before the surgery.
  
  
  RESULTS
  The mean follow-up period was 3.5 years (1 - 8 years). Nine patients had failure of union at the graft-host junction. Fracture of the stem of the prosthesis occurred in 5 patients, late infection was found in 19 patients, and aseptic loosening occurred in 3 patients. Bone fracture occurred in 1 patient and prosthesis sinking occurred in 2 patients.
  
  
  CONCLUSIONS
  The tumor-type prosthetic reconstruction offers the best knee function after resection of the tumor around the knee, and recurrence rate can be accepted. However, the tumor-type prosthesis needs further improvement because of the high complication rate.
authors.affiliation: Musculoskeletal Tumor Center, People's Hospital, Peking University, Beijing 100044, China. bonetumor@163.com
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Xian-hai
authors.initials: XH
authors.lastname: Wang
authors.forename: Da-sen
authors.initials: DS
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects / Q000379:methods*; D001859:Bone Neoplasms / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome