Methaemoglobinaemia caused by hydroxycarbamide (hydroxyurea) ingestion in a dog.
A three-year-old female neutered greyhound was presented after ingestion of its owner's hydroxycarbamide (hydroxyurea) tablets. The dog was found to be cyanosed, and methaemoglobinaemia was demonstrated by co-oximetry. Therapy included methylene blue, oxygen, packed red blood cell transfusion, N-acetylcysteine and crystalloid fluids. Methaemoglobinaemia resolved within 16 hours. Granulocyte colony-stimulating factor was administered for five days in an attempt to prevent severe neutropenia. Mild delayed transient myelotoxicity was suspected. The dog made a full recovery.
Wray
J D
JD
Centre for Small Animal Studies, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU.
D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced* / Q000628:therapy; D004285:Dogs; D004791:Enzyme Inhibitors / Q000506:poisoning*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006400:Hematocrit / Q000379:methods / Q000662:veterinary; D006918:Hydroxyurea / Q000506:poisoning*; D008708:Methemoglobinemia / Q000139:chemically induced / Q000628:therapy / Q000662:veterinary*; D008751:Methylene Blue / Q000627:therapeutic use*; D016896:Treatment Outcome
D004791:Enzyme Inhibitors; D016179:Granulocyte Colony-Stimulating Factor; D008751:Methylene Blue; D006918:Hydroxyurea