Comparative bioavailability of mineral-enriched gluconates and yeast in rat liver after depletion-repletion feeding.
There are many forms of mineral supplements currently available. Among these mineral-enriched gluconates and yeast are considered two of the more biologically available supplements. The purpose of this study was to use zinc (Zn)- or copper (Cu)-deficient rats to determine whether the organically bound mineral in yeast or the salt gluconate form was more bioavailable, i.e., is absorbed and found in a greater concentration in liver. It was demonstrated that Zn-enriched yeast was 3.7 times more bioavailable than the Zn gluconate and that Cu-enriched yeast was 1.4 times more bioavailable than the Cu gluconate.
Vinson
Joe A
JA
Department of Chemistry, University of Scranton, Scranton, PA 18510, USA.
Tompkins
Thomas A
TA
Agbor
Gabriel A
GA
D000818:Animals; D001682:Biological Availability; D003300:Copper / Q000737:chemistry / Q000172:deficiency / Q000493:pharmacokinetics; D004032:Diet; D005215:Fasting; D005942:Gluconates / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D008099:Liver / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D051381:Rats; D015002:Yeast, Dried / Q000493:pharmacokinetics*; D015032:Zinc / Q000737:chemistry / Q000172:deficiency / Q000493:pharmacokinetics
D005942:Gluconates; D003300:Copper; D015032:Zinc