title: Antibodies to 46-kDa retinal antigen in a patient with breast carcinoma and cancer-associated retinopathy.
abstract: Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome usually associated with small-cell lung carcinoma and serum autoantibodies against recovering. We report the breast cancer woman with visual impairments and electrophysiological abnormalities characteristic of CAR. Her serum contained high-titer antibodies against alpha-enolase but not against other retinal proteins. This suggests that anti-enolase antibodies could be responsible for the development of CAR symptoms.
authors.affiliation: Department of Neurology, Wrocław Medical University, Wrocław, Poland. mejma@interia.pl
authors.forename: Maria
authors.initials: M
authors.lastname: Ejma
authors.forename: Marta
authors.initials: M
authors.lastname: Misiuk-Hojło
authors.forename: Wojciech A
authors.initials: WA
authors.lastname: Gorczyca
authors.forename: Ryszard
authors.initials: R
authors.lastname: Podemski
authors.forename: Stanisław
authors.initials: S
authors.lastname: Szymaniec
authors.forename: Marianna
authors.initials: M
authors.lastname: Kuropatwa
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Rogozińska-Szczepka
authors.forename: Wiesława
authors.initials: W
authors.lastname: Bartnik
mesh_terms: D001943:Breast Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D002277:Carcinoma / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D045744:Cell Line, Tumor; D004594:Electrophysiology / Q000379:methods; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D012160:Retina / Q000378:metabolism*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology*; D055752:Small Cell Lung Carcinoma / Q000150:complications / Q000473:pathology; D014785:Vision, Ocular
chemical_list: D010751:Phosphopyruvate Hydratase