Exposure to sibutramine during pregnancy.
OBJECTIVE
One of my patients who was taking sibutramine to lose weight found out that she had unexpectedly conceived. The medication was stopped as soon as she found out, about 5 weeks into the pregnancy. Is the baby at risk? Should the pregnancy be aborted?


CONCLUSIONS
No data to date suggest that involuntary exposure to sibutramine during pregnancy carries major risk of congenital malformations. Nevertheless, this medication should be avoided whenever possible during pregnancy, as there is little information on its effects.
Garcia-Bournissen
Facundo
F
Shrim
Alon
A
Koren
Gideon
G
D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015331:Cohort Studies; D003503:Cyclobutanes / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000523:psychology; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D018570:Risk Assessment
D000928:Antidepressive Agents; D003503:Cyclobutanes; C058254:sibutramine