title: Beta-orcinol metabolites from the lichen Hypotrachyna revoluta.
abstract: Four new beta-orcinol metabolites, hypotrachynic acid (1), deoxystictic acid (2), cryptostictinolide (3) and 8'-methylconstictic acid (4) along with the metabolites 8'-methylstictic acid (5), 8'-methylmenegazziaic acid (6), stictic acid (7), 8'-ethylstictic acid (8) and atranorin (9), that have been previously described, were isolated for the first time from the tissue extracts of the lichen Hypotrachyna revoluta (Flörke) Hale. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analyses. Radical scavenging activity (RSA) of the metabolites isolated in adequate amounts, was evaluated using luminol chemiluminescence and comparison with Trolox.
authors.affiliation: University of Athens, Department of Pharmacy, Division of Pharmacognosy and Chemistry of Natural Products, Panepistimioupoli Zographou, Athens, 157 71, Greece. pennypbp@yahoo.gr
authors.forename: Panagiota
authors.initials: P
authors.lastname: Papadopoulou
authors.forename: Olga
authors.initials: O
authors.lastname: Tzakou
authors.forename: Constantinos
authors.initials: C
authors.lastname: Vagias
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Kefalas
authors.forename: Vassilios
authors.initials: V
authors.lastname: Roussis
mesh_terms: D016166:Free Radical Scavengers / Q000302:isolation & purification* / Q000494:pharmacology; D008011:Lichens / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D012118:Resorcinols / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D016166:Free Radical Scavengers; D012118:Resorcinols; C005282:orcinol