title: Glucose tolerance abnormalities in Australian women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine the prevalence of glucose tolerance abnormalities and to identify associated risk factors in women with polycystic ovary syndrome (PCOS) attending a reproductive endocrinology clinic.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  372 women with confirmed PCOS attending a reproductive endocrinology clinic at Adelaide University's Research Centre for Reproductive Health.
  
  
  METHODS
  Prevalence of glucose tolerance abnormalities and association of such abnormalities with potential risk factors.
  
  
  RESULTS
  4.0% (15 women) had diabetes mellitus, 15.6% (58) had impaired glucose tolerance and 80.4% (299) had normal glucose tolerance. There was a significant trend towards increasing prevalence of diabetes with increasing age (odds ratio [OR], 0.60; P = 0.0085). The prevalence of abnormal glucose tolerance (diabetes and impaired glucose tolerance together) was significantly higher with higher waist circumference (OR, 2.9; P = 0.05), higher body mass index (OR, 8.02; P = 0.0253), a family history of diabetes (OR, 1.56; P = 0.0192) and the presence of metabolic syndrome (OR, 5.62; P < 0.001).
  
  
  CONCLUSIONS
  The prevalence of diabetes and impaired glucose tolerance is high in women with PCOS, especially in older women and those with abdominal obesity and a family history of diabetes.
authors.affiliation: Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA, Australia.
authors.forename: Preeti
authors.initials: P
authors.lastname: Dabadghao
authors.forename: Bronwen J
authors.initials: BJ
authors.lastname: Roberts
authors.forename: Jim
authors.initials: J
authors.lastname: Wang
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Davies
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Norman
mesh_terms: D000293:Adolescent; D000328:Adult; D048909:Diabetes Complications; D005260:Female; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000150:complications; D005951:Glucose Tolerance Test; D006801:Humans; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D012189:Retrospective Studies
chemical_list: D005947:Glucose