Pulmonary lymphoma developed during long-term methotrexate therapy for psoriasis.
Low dose weekly administration of methotrexate has been thought to be effective for both rheumatoid arthritis (RA) and psoriasis. However, there is a possibility that methotrexate therapy may be oncogenic. This report presents a case of pulmonary lymphoma developed during long-term methotrexate therapy for psoriasis. Physicians should be aware that Epstein-Barr virus-associated lymphoproliferative disorders that occur during treatment with methotrexate are not specific to patients with RA.
Suzuki
Manabu
M
Department of Respiratory Medicine, International Medical Center of Japan Hospital, Tokyo, Japan.
Hirano
Satoshi
S
Ito
Hideyuki
H
Matsubara
Daisuke
D
Kubota
Kazuo
K
Takeda
Yuichiro
Y
Sugiyama
Haruhito
H
Kobayashi
Nobuyuki
N
Kudo
Koichiro
K
D000328:Adult; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008223:Lymphoma / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D011379:Prognosis; D011565:Psoriasis / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
D007166:Immunosuppressive Agents; D008727:Methotrexate