[(11)C]-PIB imaging in patients with Parkinson's disease: preliminary results.
[(11)C]-PIB positron emission tomography ([(11)C]-PIB PET) is a sensitive marker of amyloid in Alzheimer's disease (AD), but its specificity has not been fully evaluated. Vascular amyloid-beta deposition is common in Parkinson's disease (PD) and alpha-synuclein, the major component of the Lewy bodies in PD, forms amyloid fibrils. We investigated five apparently cognitively normal PD patients with [(11)C]-PIB PET. The results were compared to 16 patients with AD and six healthy controls from a previous study. [(11)C]-PIB retention was not significantly increased in our patients who all had early stage PD. Further studies of more advanced PD patients are warranted.
Johansson
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A
Department of Neurology, University Hospital, SE-751 85 Uppsala, Sweden. anders.johansson@neurologi.uu.se
Savitcheva
I
I
Forsberg
A
A
Engler
H
H
Långström
B
B
Nordberg
A
A
Askmark
H
H
D000368:Aged; D000814:Aniline Compounds; D052160:Benzothiazoles / Q000378:metabolism*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D052160:Benzothiazoles; D013844:Thiazoles