A triazole-templated ring-closing metathesis for constructing novel fused and bridged triazoles.
The feasibility of trapping the vinyl copper intermediate generated in situ from azide-[3 + 2] cycloadditions and viability of employing these triazoles as unique templates for ring-closing metathesis are described here; this work effectively combines the two powerful reactions for the first time to construct various de novo fused and bridged triazoles that are otherwise not trivial to synthesize.
Zhang
Xuejun
X
Division of Pharmaceutical Sciences and Department of Chemistry, 777 Highland Avenue, University of Wisconsin, Madison, WI 53705-2222, USA.
Hsung
Richard P
RP
Li
Hongyan
H
D003500:Cyclization; D014230:Triazoles / Q000737:chemistry*
D014230:Triazoles