title: Influence of FDG-PET on computed tomography-based radiotherapy planning for locally recurrent nasopharyngeal carcinoma.
abstract: OBJECTIVE
  Assuming F-18-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET)/computed tomography (CT) to be more accurate in representing the true disease extent than CT alone, we prospectively designed this study to evaluate how the addition of FDG-PET influences CT-based radiotherapy planning for locally recurrent nasopharyngeal carcinoma.
  
  
  METHODS
  All patients underwent FDG-PET/CT simulation scans. For each patient, the gross tumor volume (GTV) was separately delineated with or without the addition of PET information and defined as GTV PET/CT and GTV CT, respectively. Corresponding planning target volumes (PTV) were generated for the GTV CT (PTV(CT)) and GTV PET/CT (PTV PET/CT). Three-dimensional conformal radiotherapy plans were separately created for PTV CT and PTV PET/CT. To assess the potential geographic miss of the PET/CT-based disease in CT-based treatment planning, the size and location of the GTV PET/CT, PTV(PET/CT), and PTV(CT) were analyzed, and the three-dimensional conformal radiotherapy plans created using the PTV CT were evaluated with the GTV PET/CT and PTV PET/CT information.
  
  
  RESULTS
  A total of 43 patients were enrolled in this study. Distant metastasis was found in 4 patients with the addition of the PET information. The 39 patients without distant metastasis proceeded to three-dimensional conformal radiotherapy planning. Inadequate coverage of the GTV PET/CT and PTV PET/CT by the PTV CT occurred in 7 (18%) and 20 (51%) patients, respectively. This resulted in <95% of the GTV(PET/CT) and PTV PET/CT receiving >or=95% of the prescribed dose in 4 (10%) and 13 (33%) patients, respectively.
  
  
  CONCLUSIONS
  The addition of FDG-PET information might influence CT-based radiotherapy planning for locally recurrent nasopharyngeal carcinoma by altering the definition of the target volume, with the potential to avoid a geographic miss of true disease.
authors.affiliation: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China. zkn1268@fimmu.com
authors.forename: Xiao-Kang
authors.initials: XK
authors.lastname: Zheng
authors.forename: Long-Hua
authors.initials: LH
authors.lastname: Chen
authors.forename: Quan-Shi
authors.initials: QS
authors.lastname: Wang
authors.forename: Hu-Bing
authors.initials: HB
authors.lastname: Wu
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Wang
authors.forename: Yong-Qin
authors.initials: YQ
authors.lastname: Chen
authors.forename: Wei-Pin
authors.initials: WP
authors.lastname: Yan
authors.forename: Qi-Sheng
authors.initials: QS
authors.lastname: Li
authors.forename: Yi-Kai
authors.initials: YK
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D003497:Cyclic N-Oxides; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008623:Mercaptoethanol / Q000031:analogs & derivatives; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D049268:Positron-Emission Tomography / Q000379:methods; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003497:Cyclic N-Oxides; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008623:Mercaptoethanol; C040255:SL-mercaptoethanol