Comparison of obstetric outcomes in recipients of donor oocytes vs. women of advanced maternal age with autologous oocytes.
OBJECTIVE
To evaluate obstetric complications in women conceiving with donated oocytes as compared to controls of advanced maternal age.


METHODS
We compared the obstetric outcomes of a cohort of 69 women who conceived through oocyte donation to all women over 38 years old (n = 681) who delivered at the same hospital in the same period. We first compared obstetric complications and outcomes in the entire cohort. Additional comparisons were made while controlling for multiple covariates: maternal and fetal complications, mode of delivery, estimated gestational age and infant weight at delivery.


RESULTS
Women who conceived with donor oocytes were older than controls. In the cohort, oocyte recipients were at increased risk for several obstetric complications. However, when controlling for age and multiple gestations, only preterm labor, preeclampsia and protracted labor were increased in oocyte recipients.


CONCLUSIONS
Women who conceive with donor oocytes might be at increased risk of complications during pregnancy. When age and multiple gestations are accounted for, these patients remain at risk for preterm labor, preeclampsia and protracted labor requiring cesarean delivery.
Henne
Melinda B
MB
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.
Zhang
Mallory
M
Paroski
Sylvie
S
Kelshikar
Bhagyashree
B
Westphal
Lynn M
LM
D000328:Adult; D002585:Cesarean Section; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D007752:Obstetric Labor, Premature / Q000209:etiology; D010298:Parity; D011225:Pre-Eclampsia / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D014019:Tissue Donors