title: Acute lower limb ischemia as the initial symptom of acute myeloid leukemia.
abstract: Although coagulatory system disorders are well recognized in patients with acute leukemia, these usually present with either hemorrhagic complications or thrombosis of small vessels. Large vessel thrombosis is a very rare clinical presentation. We present a patient with previously undiagnosed acute myeloid leukemia (M5), who was referred to our hospital with symptoms of acute ischemia of his right lower limb. Occlusion of the right external iliac artery due to a combination of leucostasis and coagulation disorders was noted and successfully treated with urgent leukapheresis, immediate chemotherapy and surgical thromboembolectomy.
authors.affiliation: Vascular Surgery Division, University of Crete Medical School, Heraklion, Greece.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Kafetzakis
authors.forename: Andreas
authors.initials: A
authors.lastname: Foundoulakis
authors.forename: Christos V
authors.initials: CV
authors.lastname: Ioannou
authors.forename: Emilia
authors.initials: E
authors.lastname: Stavroulaki
authors.forename: Anastassios
authors.initials: A
authors.lastname: Koutsopoulos
authors.forename: Asterios N
authors.initials: AN
authors.lastname: Katsamouris
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007511:Ischemia / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D007866:Leg / Q000098:blood supply* / Q000601:surgery; D007937:Leukapheresis; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology; D012907:Smoking; D017131:Thrombectomy; D013927:Thrombosis / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents