title: Serologic response to oncogenic human papillomavirus types in male and female university students in Busan, South Korea.
abstract: In the absence of genital samples, human papillomavirus (HPV) serology may be useful to assess HPV infection in young men and women. HPV seroprevalence and determinants of seropositivity were assessed in 817 female and 518 male university students in Busan, South Korea, of whom 74% and 44%, respectively, reported never having had penetrative sexual intercourse. Type-specific HPV DNA status, assessed by a short PCR fragment primer set, was available from genital samples. Seropositivity to L1 proteins of HPV types 16, 18, 31, 33, 45, 52, and 58 were assessed using multiplex HPV serology. Among women, HPV seroprevalence was significantly higher among sexually active (26.1%) than nonsexually active students [11.1%, odds ratio (OR) = 2.9; 95% confidence interval (95% CI), 1.8-4.7], although the association was weaker than that for HPV DNA prevalence (OR, 14; 95% CI, 4.7-42). Furthermore, HPV seroprevalence was higher among HPV DNA-positive (24%) than HPV DNA-negative women (13%), and there was a positive correlation of type-specific seroprevalence with the presence of HPV DNA of the same type. In contrast, HPV seropositivity among men was not associated with sexual behavior or the presence of HPV DNA. Seroprevalence correlates with genital HPV exposure in young women, but its meaning in young men is unclear.
authors.affiliation: IARC, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France.
authors.forename: Gary M
authors.initials: GM
authors.lastname: Clifford
authors.forename: Hai-Rim
authors.initials: HR
authors.lastname: Shin
authors.forename: Jin-Kyoung
authors.initials: JK
authors.lastname: Oh
authors.forename: Tim
authors.initials: T
authors.lastname: Waterboer
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Ju
authors.forename: Salvatore
authors.initials: S
authors.lastname: Vaccarella
authors.forename: Wim
authors.initials: W
authors.lastname: Quint
authors.forename: Michael
authors.initials: M
authors.lastname: Pawlita
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D015994:Incidence; D007723:Korea; D008297:Male; D027383:Papillomaviridae / Q000276:immunology / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000517:prevention & control / Q000821:virology; D016036:Seroepidemiologic Studies; D012725:Sexual Behavior; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000517:prevention & control / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral