TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy.
TDAG51 (T cell death-associated gene 51) is an apoptosis-associated protein. Our aim was to investigate TDAG51 expression in the anterior temporal neocortex of patients with intractable epilepsy (IE), and then to discuss the possible role of TDAG51 in IE. Tissue samples from the anterior temporal neocortex of 33 patients who had surgery for IE were used to detect TDAG51 expression by immunohistochemistry, immunofluorescence, and Western blotting. We compared these tissues with nine histologically normal anterior temporal lobes from intracranial hypertension patients who had decompression procedures. TDAG51 was mainly expressed in the cytoplasm of neurons and glial cells. TDAG51 in IE was significantly higher than that in the controls. These findings were consistently observed using Western blotting, immunofluorescence, and immunohistochemistry techniques. TDAG51 in patients with IE was significantly higher when compared with levels in the controls. This finding suggests TDAG51 is consistent with a possible role of this gene in the evolution of the pathology in IE.
Xi
Zhi-qin
ZQ
Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China.
Wang
Lin-yuan
LY
Sun
Ji-jun
JJ
Liu
Xian-zeng
XZ
Zhu
Xi
X
Xiao
Fei
F
Guan
Li-feng
LF
Li
Jin-mei
JM
Wang
Liang
L
Wang
Xue-feng
XF
D000293:Adolescent; D000328:Adult; D002648:Child; D004827:Epilepsy / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D013702:Temporal Lobe / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
C491923:PHLDA1 protein, human; D014157:Transcription Factors