The interleukin-1 receptor antagonist gene and the inhibitor of kappa B-like protein gene polymorphisms are not associated with myocardial infarction in Slovene population with type 2 diabetes.
In this study we investigated the association of the interleukin-1 receptor antagonist gene variable number tandem repeat (IL1RN VNTR) polymorphism and of the inhibitor of kappa B-like protein (IKBL) gene polymorphism with myocardial infarction (MI) in a group of patients with type 2 diabetes. The IL1RN VNTR and the IKBL+ 738T > C gene polymorphisms were tested in 374 Caucasians: 151 cases with MI and 223 subjects with no history of coronary artery disease. The IL1RN VNTR polymorphism was not a risk factor for MI in Caucasians with type 2 diabetes (genotype 22 vs. the rest: odds ratio (OR) 1.6; 95% confidence interval (CI) = 0.8-3.5; p = 0.2). We also failed to demonstrate that IKBL+ 738T > C gene polymorphism was associated with MI in patients with type 2 diabetes (OR = 0.9; 95% CI = 0.3-2.6; p = 0.9). We provide evidence that the IL1RN VNTR and the IKBL + 738T > C gene polymorphisms are not risk factors for MI in Caucasians with type 2 diabetes.
Kariz
Stojan
S
Department of Internal Medicine, General Hospital "Izola", Izola, Slovenia.
Milutinović
Aleksandra
A
Bregar
Dejan
D
Terzić
Ibrahim
I
Terzić
Rifet
R
Lovrecić
Luca
L
Herova
Magdalena
M
Hruskovicova
Helena
H
Peterlin
Borut
B
Petrovic
Danijel
D
Zorc-Pleskovic
Ruda
R
D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D017524:Slovenia / Q000453:epidemiology
D048868:Adaptor Proteins, Signal Transducing; D000949:Histocompatibility Antigens Class II; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; C120111:NFKBIL1 protein, human