title: Stimulation of gastric acid secretion and intestinal motility by Vernonia amygdalina extract.
abstract: Aqueous extract of Vernonia amygdalina infused intragastrically at a dose of 10 mg/ml to rats induced a significant increase in acid output which was reduced by, ranitidine (5 mg/kg b.w.) or atropine (1.2 microMol/kg b.w.). Moreover the extract evoked a dose-dependent contraction of the guinea pig ileum at a dose range of 0.6 mg/ml to 66 mg/ml which was inhibited by atropine (2.4 x 10(-8)-2.4 x 10(-6) M).
authors.affiliation: Department of Physiology, College of Medical Sciences, University of Calabar, Calabar 540001, Nigeria. d_owu@yahoo.com
authors.forename: D U
authors.initials: DU
authors.lastname: Owu
authors.forename: E E
authors.initials: EE
authors.lastname: Ben
authors.forename: A B
authors.initials: AB
authors.lastname: Antai
authors.forename: E A
authors.initials: EA
authors.lastname: Ekpe
authors.forename: P M
authors.initials: PM
authors.lastname: Udia
mesh_terms: D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D013270:Stomach / Q000187:drug effects*; D035741:Vernonia
chemical_list: D010936:Plant Extracts