title: Evaluation of systolic and systo-diastolic function: the Tei index in acute myocardial infarction treated with acute reperfusion therapy--early and late evaluation.
abstract: BACKGROUND
  Evaluation of systolic and diastolic function by non-invasive methods in the acute phase of myocardial infarction (MI) is of great importance for risk stratification and prognosis. Ejection fraction (EF), as determined by echocardiography using the Simpson method, is the main parameter for assessing left ventricular (LV) function. The Tei index (TI), a Doppler-derived index that reflects systolic and diastolic function in MI, has an excellent correlation with prognosis.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate systolic and systo-diastolic function in the acute and late phase of ST-elevation MI treated with acute reperfusion therapy.
  
  
  METHODS
  Patients with ST-elevation MI who underwent acute reperfusion therapy were evaluated by echocardiography in the first 48 hours and after one week. The parameters studied were: EF, wall motion score index (WMSI), and TI. The values obtained at the first and second evaluation were compared and correlated with pain to reperfusion time (PRT) (<3 vs. > or =3 hours), presence of single or multivessel disease, ejection fraction, total CK (<1500 or > or =1500 UI/l), and MI location (anterior vs. other).
  
  
  RESULTS
  40 patients were studied and 19 were included, of whom 15 (80%) were male, mean age 57 +/- 14 years. Risk factors included hypertension (11 patients, 58%), smoking (14, 74%), diabetes (6, 30%), and dyslipidemia (12, 63%). MI location was anterior in 6 patients (32%) and inferior in 13 (68%). Five patients (26%) underwent fibrinolysis and 14 (74%) direct percutaneous coronary intervention. Mean pain to reperfusion time was 3.7 +/- 2.8 hours. Four patients (21%) had single vessel disease and 14 (74%) multivessel disease. Significant differences were found: (a) in mean EF and WMSI between the two evaluations (p < 0.0001 and p = 0.002 respectively); (b) between PRT and EF (p = 0.001) and WMSI (p = 0.020) at 48 hours; (c) between PRT and EF (p = 0.01) and TI (p = 0.033), and MI location and EF (p = 0.005) after one week.
  
  
  CONCLUSIONS
  Early systolic function and LV remodeling one week after MI were accurately evaluated by EF and WMSI. Early reperfusion therapy positively influences early and late systolic and systo-diastolic function.
authors.affiliation: Serviço de Cardiologia, Hospital Garcia de Orta, E.P.E., Almada, Portugal. luisrlopes@hotmail.com
authors.forename: Luís Rocha
authors.initials: LR
authors.lastname: Lopes
authors.forename: Isabel
authors.initials: I
authors.lastname: João
authors.forename: Hugo
authors.initials: H
authors.lastname: Vinhas
authors.forename: Otília
authors.initials: O
authors.lastname: Simões
authors.forename: Carlos
authors.initials: C
authors.lastname: Cotrim
authors.forename: Carlos
authors.initials: C
authors.lastname: Catarino
authors.forename: Manuel
authors.initials: M
authors.lastname: Carrageta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003971:Diastole; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D015425:Myocardial Reperfusion; D011446:Prospective Studies; D013599:Systole; D015912:Thrombolytic Therapy; D013997:Time Factors; D014463:Ultrasonography