[Intrahepatic cholestasis of pregnancy: a disorder with increased fetal risks. Part II: fetal condition and medical management].
The aim of this review was to present recent information about the fetal condition in cases of intrahepatic cholestasis of pregnancy. A relatively mild course of maternal disease does not predict fetal well-being accurately. Increased risk of sudden intrauterine death was emphasized, implicating the need for more stringent obstetric monitoring of fetal condition in this disorder. A pathogenetic mechanism leading to sudden deterioration of fetal wellbeing was proposed and discussed. Current recommendations regarding medical management of intrahepatic cholestasis of pregnancy were also presented.
Jóźwik
Maciej
M
Klinika Ginekologii Akademii Medycznej w Białymstoku. jozwikmc@interia.pl
Jóźwik
Marcin
M
Bartnicki
Janusz
J
Jóźwik
Michał
M
D000328:Adult; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis* / Q000517:prevention & control / Q000628:therapy*; D005260:Female; D005313:Fetal Death / Q000517:prevention & control; D005323:Fetal Monitoring / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000517:prevention & control / Q000628:therapy*; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D011295:Prenatal Care / Q000379:methods; D011296:Prenatal Diagnosis / Q000379:methods*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors