title: Diffuse spine involvement in sarcoidosis with sternal lytic lesions: two case reports.
abstract: METHODS
  Case report.
  
  
  OBJECTIVE
  To report 2 cases of sarcoidosis with a diffuse vertebral involvement, associated with a rare location in the sternum.
  
  
  BACKGROUND
  Sarcoidosis is a systemic disease of unknown cause with various clinical and radiologic manifestations. Bone involvement is rare (1%-13% of cases). Vertebral involvement is very uncommon. Lytic lesions, sclerotic lesions, or both of these patterns may be observed.
  
  
  METHODS
  One patient complained of diffuse bone pain; the second patient was asymptomatic. Each patient had radiograph, CT, and MRI of the spine. The second patient also underwent a PET/CT FDG-(18F). Sternal bone biopsy was performed in both patients. Pathologic findings indicated typical pattern of bone sarcoidosis. Clinical and biologic improvement was noticed after treatment with corticosteroids.
  
  
  RESULTS
  In our 2 cases, radiograph, CT, MRI, and PET/CT findings were evocative of diffuse spine involvement in sarcoidosis associated with sternal lytic lesions. This suspicion was confirmed by histopathologic findings, which found a typical pattern of sarcoidosis.
  
  
  CONCLUSIONS
  These 2 cases emphasize the value of CT, MRI, and FDG-(18F) PET/CT for the diagnosis of diffuse spinal involvement in sarcoidosis and describe an exceptional association with sternal lytic lesions.
authors.affiliation: Service de Radiologie, APHP, Hôpital Bichat, Paris, France. fredclare5@msn.com
authors.forename: Frédéric
authors.initials: F
authors.lastname: Clarençon
authors.forename: Olivia
authors.initials: O
authors.lastname: Silbermann-Hoffman
authors.forename: Caroline
authors.initials: C
authors.lastname: Lebreton
authors.forename: Pédro
authors.initials: P
authors.lastname: Fernandez
authors.forename: Khaldoun
authors.initials: K
authors.lastname: Kerrou
authors.forename: Sylvain
authors.initials: S
authors.lastname: Marchand-Adam
authors.forename: Muriel
authors.initials: M
authors.lastname: Hourseau
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Schouman-Claeys
authors.forename: Antoine
authors.initials: A
authors.lastname: Feydy
mesh_terms: D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010014:Osteolysis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D010026:Osteosclerosis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D010146:Pain / Q000209:etiology / Q000473:pathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012507:Sarcoidosis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D013122:Spinal Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D013249:Sternum / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18