title: Medication adherence skills training for middle-aged and elderly adults with bipolar disorder: development and pilot study.
abstract: OBJECTIVE
  To present the rationale, development, and pilot study of a medication adherence skills training (MAST-BD) intervention for older adults with bipolar disorder (BPD). We developed a 12-week manualized group intervention that combined educational, motivational, medication management skills and symptom management training adapted for older adults.
  
  
  METHODS
  Among 21 older outpatients with BPD (mean age = 60 years; SD = 6), the feasibility and acceptability of MAST-BD were assessed in a quasi-experimental clinical trial. We also obtained preliminary effect sizes associated with pre-post change on measures of self-reported adherence to psychiatric medications, performance-based medication management ability, attitudes toward medication, depressive and manic symptoms, and health-related quality of life.
  
  
  RESULTS
  At baseline, 55% of participants reported recent non-adherence to psychiatric medications and were, on average, suffering from moderately severe depressive symptoms and minimal symptoms of mania. A total of 76% of participants completed the intervention, and 86% of sessions were attended by completers. Participants reported high levels of satisfaction with the intervention and manual. Pre-post improvement by small to medium effect sizes (Cohen's d = 0.30-0.57) was seen in medication adherence, medication management ability, depressive symptoms, and selected indices of health-related quality of life.
  
  
  CONCLUSIONS
  Notwithstanding the limitations of this small preliminary study, the results are encouraging in that the MAST-BD intervention was feasible, acceptable to patients, and associated with improvement in key outcomes. Suggestions for further development of medication adherence interventions for this neglected group of patients are discussed.
authors.affiliation: Department of Psychiatry, University of California, San Diego, CA 92161, USA. cedpp@ucsd.edu
authors.forename: Colin A
authors.initials: CA
authors.lastname: Depp
authors.forename: Barry D
authors.initials: BD
authors.lastname: Lebowitz
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Patterson
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Lacro
authors.forename: Dilip V
authors.initials: DV
authors.lastname: Jeste
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008875:Middle Aged; D010349:Patient Compliance; D010353:Patient Education as Topic; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D012565:Schizophrenic Psychology; D011795:Surveys and Questionnaires