Preparation and antitubercular activities of alkylated amino alcohols and their glycosylated derivatives.
A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5mug/mL. The presence of the carbohydrate slightly affected the antibacterial activity.
Taveira
Aline F
AF
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora-MG 36036-330, Brazil.
Hyaric
Mireille Le
ML
Reis
Elaine F C
EF
Araújo
Débora P
DP
Ferreira
Ana Paula
AP
de Souza
Maria Aparecida
MA
Alves
Lívia L
LL
Lourenço
Maria C S
MC
Vicente
Felipe Rodrigues C
FR
de Almeida
Mauro V
MV
D000478:Alkylation; D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation; D002478:Cells, Cultured; D006031:Glycosylation; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000605:Amino Alcohols; D000995:Antitubercular Agents