A nonacid degradable linker for solid-phase synthesis.
Synthesis and applications of two new nonacid degradable linkers as an alternative to the Wang linker for solid-phase synthesis are described. Resin from linker 2 looks superior to linker 1 in terms of yields for both anchoring of the first building block and cleavage and in terms of higher purity of the final product. Use of linker 2 avoids side reactions associated with the use of Wang resin due to an undesired cleavage during final acid treatment.
Colombo
Aina
A
Almirall-Barcelona Science Park Unit, Josep Samitier 1-5, E-08028 Barcelona, Spain.
De la Figuera
Natalia
N
Fernàndez
Joan Carles
JC
Fernández-Forner
Dolors
D
Albericio
Fernando
F
Forns
Pilar
P
D000596:Amino Acids / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry*
D000596:Amino Acids; D001713:Biphenyl Compounds; D010455:Peptides; D011137:Polystyrenes; C514402:Wang resin