Antibiotic resistance and single-nucleotide polymorphism cluster grouping type in a multinational sample of resistant Mycobacterium tuberculosis isolates.
A single-nucleotide polymorphism-based cluster grouping (SCG) classification system for Mycobacterium tuberculosis was used to examine antibiotic resistance type and resistance mutations in relationship to specific evolutionary lineages. Drug resistance and resistance mutations were seen across all SCGs. SCG-2 had higher proportions of katG codon 315 mutations and resistance to four drugs.
Brimacombe
M
M
Department of Preventive Medicine and Community Health, New Jersey Medical School-UMDNJ, 185 S. Orange Ave., MSB F-647, Newark, NJ 07083, USA. brimacmb@umdnj.edu
Hazbon
M
M
Motiwala
A S
AS
Alland
D
D
D001426:Bacterial Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques / Q000379:methods; D002374:Catalase / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D001426:Bacterial Proteins; D002374:Catalase; C480353:katG protein, Mycobacterium tuberculosis