Microvessel density in sinus augmentation procedures using anorganic bovine bone and autologous bone: 3 months results.
OBJECTIVE
This study was an immunohistochemical evaluation of microvessel density (MVD) in sinus augmentation procedures with autologous bone and anorganic bone (Bio-Oss).


METHODS
Twenty-four patients (14 men and 10 women - mean age of 48 years with a range from 34 to 53 years) participated in this study. All the patients presented a maxillary partial unilateral edentulism involving the premolar/molar areas, with a residual alveolar ridge height of about 4 to 5 mm. Twelve patients received sinus augmentation procedures with 100% autologous bone; 100% Bio-Oss was used in the other 12 patients. Endosseous implants were inserted after a mean period of 3 months. As control, the portions of preexisting subantral bone were used. The mean value of the MVD in control bone was 23.4 +/- 1.3. The mean value of the MVD in the sinuses augmented with autologous bone was 29.0 +/- 2.4. The mean value of the MVD in the sinuses augmented with Bio-Oss was 23.8 +/- 2.2.


RESULTS
The statistical analysis showed that the differences of the MVD between control bone and sinuses augmented with Bio-Oss were not statistically significant (P = 0.52), while the difference of the MVD between sinuses augmented with autologous bone and those augmented with Bio-Oss was statistically significant (P = 0.0008).


CONCLUSIONS
Autologous bone may act not only as a passive filling material in bone defects but may also release osteogenic growth factors; and particles of autologous bone seem to contain vital osteoprogenitor cells.
Degidi
Marco
M
Dental School, University of Chieti-Pescara, Italy.
Artese
Luciano
L
Rubini
Corrado
C
Perrotti
Vittoria
V
Iezzi
Giovanna
G
Piattelli
Adriano
A
D000328:Adult; D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D003758:Dental Implantation, Endosseous / Q000379:methods; D005260:Female; D006801:Humans; D007576:Jaw, Edentulous, Partially / Q000000981:diagnostic imaging / Q000534:rehabilitation*; D008297:Male; D008443:Maxillary Sinus / Q000098:blood supply / Q000601:surgery*; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D011859:Radiography
C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals