title: In vivo long-term effects of retinoic acid exposure in utero on induced hyperplastic epidermal foci in murine skin.
abstract: Adult Naval Medical Research Institute (NMRI) mice, after prenatal exposure to retinoic acid (RA), were treated with a standard two-stage skin carcinogenesis regime to characterize hyperplastic epidermal foci that precede the appearance of cutaneous papillomas, and to investigate the in vivo long-term action of RA on adult mouse skin treated with DMBA (7,12 dimethyl benz[a]anthracene) and TPA (12-O-tetradecanoylphorbol 13-acetate). The results demonstrate that RA administered to pregnant mice had a long-term inhibitory action on the cell differentiation and development of hyperplastic lesions occurring prior to cancer on the adult skin of their offspring as well as a stimulatory effect on cell proliferation of these hyperplastic lesions.
authors.affiliation: Histology and Pathological Anatomy Section, Department of Animal Medicine and Surgery, Faculty of Veterinary Science, University of Madrid (UCM), Madrid, Spain.
authors.forename: Rosa A
authors.initials: RA
authors.lastname: García-Fernández
authors.forename: Claudia
authors.initials: C
authors.lastname: Pérez-Martínez
authors.forename: Javier
authors.initials: J
authors.lastname: Espinosa-Alvarez
authors.forename: Maria J
authors.initials: MJ
authors.lastname: García-Iglesias
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002454:Cell Differentiation / Q000187:drug effects*; D004195:Disease Models, Animal; D005260:Female; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012867:Skin / Q000166:cytology / Q000187:drug effects*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D014212:Tretinoin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D002273:Carcinogens; D007641:Keratolytic Agents; D014212:Tretinoin; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate