Carbamazepine reduces the behavioural manifestations of tinnitus following salicylate treatment in rats.
CONCLUSIONS
The results are consistent with the hypothesis that carbarmazepine (CBZ) has efficacy against tinnitus in humans.


OBJECTIVE
CBZ is an anti-epileptic drug that is widely used for the treatment of tinnitus. Despite this, there are relatively few clinical trials or preclinical studies supporting its efficacy. In an effort to increase the amount of information available on CBZ, the aim of this study was to investigate the efficacy of CBZ in salicylate-induced tinnitus in rats


METHODS
We investigated the effects of CBZ in an animal model of tinnitus induced by the injection of salicylate using a conditioned lick suppression paradigm.


RESULTS
We found that CBZ, at a dose of 15 mg/kg i.p., but not at 5 mg/kg or 30 mg/ kg, significantly suppressed the behavioural manifestations of tinnitus.
Zheng
Yiwen
Y
Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Hooton
Katie
K
Smith
Paul F
PF
Darlington
Cynthia L
CL
D000161:Acoustic Stimulation; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D000927:Anticonvulsants / Q000494:pharmacology*; D001245:Association Learning / Q000187:drug effects; D002220:Carbamazepine / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects*; D004597:Electroshock; D005239:Fear / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012980:Sodium Salicylate / Q000633:toxicity*; D014012:Tinnitus / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D002220:Carbamazepine; D012980:Sodium Salicylate