title: VEGF receptor Flk-1 plays an important role in c-kit expression in adipose tissue derived stem cells.
abstract: It is known that c-kit(+) cells are increased in heart after infarction. The exact origins of the cardiac c-kit(+) cells remain to be determined. We asked whether adipose tissue could be a potential source of c-kit(+) cells. Our data show that the number of c-kit(+) cells increased in adipose tissue derived stem cells when cultured with conditioned medium from neonatal cardiomyocytes grown under serum deprivation and hypoxia condition. We also found that VEGF receptor Flk-1 is involved in c-kit up regulation via ERK-mediated pathway.
authors.affiliation: Department of Molecular Pathology, University of Texas, MD Anderson Cancer Center, SCRB2, Box 951, 7435 Fannin Street, Houston, TX 77054, United States.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Bai
authors.forename: Sanga
authors.initials: S
authors.lastname: Sadat
authors.forename: Sebastian
authors.initials: S
authors.lastname: Gehmert
authors.forename: Eckhard
authors.initials: E
authors.lastname: Alt
authors.forename: Yao-Hua
authors.initials: YH
authors.lastname: Song
mesh_terms: D000273:Adipose Tissue / Q000166:cytology* / Q000378:metabolism*; D015415:Biomarkers; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D019009:Proto-Oncogene Proteins c-kit; D040301:Vascular Endothelial Growth Factor Receptor-2