Cascade coupling/cyclization process to N-substituted 1,3-dihydrobenzimidazol-2-ones.
Assembly of N-substituted 1,3-dihydrobenzimidazol-2-ones is achieved starting from methyl o-haloarylcarbamates via a CuI/amino acid catalyzed coupling with amines and subsequent condensative cyclization. A number of functional groups are tolerated by these reaction conditions, including vinyl, nitro, carboxylate, amide, ester, ketone, and silyl ether groups.
Zou
Benli
B
Department of Chemistry, Fudan University, Shanghai 200433, China.
Yuan
Qiliang
Q
Ma
Dawei
D
D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure
D001562:Benzimidazoles