Emerging role of mitogen-activated protein kinases in peripheral neuropathies.
Among the different families of intracellular molecules that can be modulated during cell damage and repair, mitogen-activated protein kinases (MAPKs) are particularly interesting because they are involved in several intracellular pathways activated by injury and regeneration signals. Despite most of the studies have been performed in non-neurological models, recently a causal role for MAPKs has been postulated in central nervous system disorders. However, also in some peripheral neuropathies, MAPK changes can occur and these modifications might be relevant in the pathogenesis of the damage as well as during regeneration and repair. In this review, the current knowledge on the role of MAPKs in peripheral neuropathies will be discussed.
Cavaletti
Guido
G
Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Monza, Italy. guido.cavaletti@unimib.it
Miloso
Mariarosaria
M
Nicolini
Gabriella
G
Scuteri
Arianna
A
Tredici
Giovanni
G
D028227:Amyloid Neuropathies, Familial / Q000188:drug therapy / Q000201:enzymology; D000970:Antineoplastic Agents / Q000009:adverse effects; D003929:Diabetic Neuropathies / Q000188:drug therapy / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000502:physiology*; D009444:Neuritis, Autoimmune, Experimental / Q000188:drug therapy / Q000201:enzymology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000201:enzymology*; D015398:Signal Transduction / Q000502:physiology
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D020928:Mitogen-Activated Protein Kinases