title: Complexes of 3d(n) metal ions with thiosemicarbazones: synthesis and antimicrobial activity.
abstract: The chelating behavior of the thiosemicarbazone derivatives of 2-hydroxy-8-R-tricyclo[7.3.1.0.(2,7)]tridecane-13-one (where R = H, CH3, C6H5) towards Co(II), Ni(II) and Cu(II) has been investigated by elemental analysis, molar conductivity measurements, UV-VIS, IR, ESR spectroscopy and thermal studies. It was deduced from the experiments performed that the ligands coordinate to metal ions in different ways--neutral bidentate or mononegative bidentate--depending on the nature of R. Also, if metal acetates are used instead of metal chlorides, the ligands coordinate in a mononegative bidentate fashion, regardless of the nature of R or the thiosemicarbazone type ligand. The antimicrobial activity of the ligands and of the complexes towards samples of Acinetobacter boumanii, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa was determined.
authors.affiliation: Inorganic Chemistry Department, University of Bucharest, 23 Dumbrava Rosie Street, sector 2, Bucharest, Romania. t_rosu0101@yahoo.com
authors.forename: Tudor
authors.initials: T
authors.lastname: Rosu
authors.forename: Aurelian
authors.initials: A
authors.lastname: Gulea
authors.forename: Anca
authors.initials: A
authors.lastname: Nicolae
authors.forename: Rodica
authors.initials: R
authors.lastname: Georgescu
mesh_terms: D000150:Acinetobacter / Q000378:metabolism; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry*; D002621:Chemistry / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D004926:Escherichia coli / Q000378:metabolism; D007477:Ions / Q000737:chemistry*; D007711:Klebsiella pneumoniae / Q000378:metabolism; D008024:Ligands; D008670:Metals / Q000737:chemistry*; D008956:Models, Chemical; D011550:Pseudomonas aeruginosa / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013211:Staphylococcus aureus / Q000378:metabolism; D013818:Thermogravimetry; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D007477:Ions; D008024:Ligands; D008670:Metals; D013882:Thiosemicarbazones; D003300:Copper