title: Bubble and corneal dimple formation after the first overnight wear of an orthokeratology lens: a case series.
abstract: OBJECTIVE
  To report the first documented case series of bubbles and corneal dimples associated with corneal reshaping after the first overnight wear of an orthokeratology lens.
  
  
  METHODS
  Three cases of transient corneal dimples are described after the first overnight use of the Be Free orthokeratology lens (BE; Ultravision Pty. Ltd., Brisbane, Australia) related to bubble formation under the posterior lens surface.
  
  
  RESULTS
  The corneal dimples were located most centrally and peripherally in correspondence to the reverse curve and did not produce a significant change in best-corrected visual acuity except in one patient, who had many bubbles in the central cornea.
  
  
  CONCLUSIONS
  The current findings suggest that the precorneal tear film between the corneal surface and the posterior orthokeratology contact lens surface plays a role in the development of bubbles and corneal dimples.
authors.affiliation: Contact Lens Sector, Department of Ophthalmology, Vision Institute of Federal University of Sao Paulo, Paulista School of Medicine (UNIFESP/EPM), Sao Paulo, Brazil. ianestillitano@oftalmo.epm.br
authors.forename: Iane
authors.initials: I
authors.lastname: Stillitano
authors.forename: Eduardo
authors.initials: E
authors.lastname: Maidana
authors.forename: Marcelo
authors.initials: M
authors.lastname: Lui
authors.forename: César
authors.initials: C
authors.lastname: Lipener
authors.forename: Ana Luisa
authors.initials: AL
authors.lastname: Höfling-Lima
mesh_terms: D000328:Adult; D003261:Contact Lenses / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology*; D020878:Device Removal; D019793:Fluorescein; D005456:Fluorescent Dyes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000628:therapy; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D020127:Recovery of Function; D012030:Refractive Errors / Q000503:physiopathology / Q000628:therapy*; D013194:Staining and Labeling; D013997:Time Factors; D014792:Visual Acuity
chemical_list: D005456:Fluorescent Dyes; D009883:Ophthalmic Solutions; D019793:Fluorescein