title: Serum lipid levels and suicidality among male patients with schizoaffective disorder.
abstract: Suicidal behavior in schizoaffective disorder is a serious problem and suicide risk during lifetime ranges between 5%-10%. Neurobiology of suicidal behavior has not been studied sufficiently, and a high number of studies are oriented toward lipid investigation. The aim of our study was to investigate whether there were differences in the level of lipids (cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides) in hospitalized suicidal (n=20) and non-suicidal (n=20) patients with schizoaffective disorder. The study also included male healthy control subjects (n=20). Hamilton Depression Rating Scale (HDRS-17), and Positive and Negative Syndrome Scale (PANSS) were used to confirm the level of psychopathology in patients with schizoaffective disorder. Severity of suicidality was measured by Scale for Suicide Ideation (SSI) at time of admission. Results of the study indicated significantly lower concentrations of cholesterol (p<0.001), LDL-cholesterol (p<0.01) and HDL-cholesterol (p<0.01). There were no differences in the number of previous hospitalization and previous suicide attempts between suicidal and non-suicidal patients (p>0.05). Duration of the illness was significantly (p<0.05) shorter in suicidal patients. Suicidal patients also had a significantly higher score on HDRS-17 (p<0.001) and PANSS (p<0.01) compared to non-suicidal patients.
authors.affiliation: Department of Psychiatry, University Hospital Zagreb, Kispatićeva 12, 10000 Zagreb, Croatia. darko.marcinko@zg.t-com.hr
authors.forename: Darko
authors.initials: D
authors.lastname: Marcinko
authors.forename: Vesna
authors.initials: V
authors.lastname: Marcinko
authors.forename: Dalibor
authors.initials: D
authors.lastname: Karlović
authors.forename: Anita
authors.initials: A
authors.lastname: Marcinko
authors.forename: Marko
authors.initials: M
authors.lastname: Martinac
authors.forename: Drazen
authors.initials: D
authors.lastname: Begić
authors.forename: Miro
authors.initials: M
authors.lastname: Jakovljević
mesh_terms: D000328:Adult; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000097:blood* / Q000523:psychology*; D013405:Suicide
chemical_list: D008055:Lipids