title: [Imaging and angiogenesis: DCE-US (dynamic contrast enhanced-ultrasonography)].
abstract: The early and functional evaluation of new treatments in oncology is a main goal. At present, technical advances in Doppler ultrasonography allow the detection of neovascularization for superficial and deep malignant tumours in order to evaluate the efficiency of new treatments such as antiangiogenic molecules. Contrast agents injection improves the efficiency of this technique and developments of perfusion softwares optimize this detection. Slow flows in tumour-microvessels can be detected. Treatment response using DCE-US (dynamic contrast enhanced-ultrasonography) can be early predicted based on changes in the vascularization before volume modification calculating perfusion parameters maximal as peak intensity, time to peak intensity, area under the curve, slope coefficient of wash-in.
authors.affiliation: Service d'échographie et UPRES EA 40-40, Département d'imagerie, Institut Gustave-Roussy, 39, rue Camille-Desmoulins 94805 Villejuif Cedex. lassau@igr.fr
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lassau
authors.forename: Alain
authors.initials: A
authors.lastname: Roche
mesh_terms: D000818:Animals; D003287:Contrast Media; D006801:Humans; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D014463:Ultrasonography / Q000379:methods
chemical_list: D003287:Contrast Media