The pharmacokinetics and metabolism of ivermectin in domestic animal species.
The pharmacokinetic properties of drugs are closely related to their pharmacological efficacy. The kinetics of ivermectin are characterised, in general terms, by a slow absorption process, a broad distribution in the organism, low metabolism, and slow excretion. The kinetics vary according to the route of administration, formulation, animal species, body condition, age, and physiological status, all of which contribute to differences in drug efficacy. Characterisation of ivermectin kinetics can be used to predict and optimise the value of the parasiticide effects and to design programmes for parasite control. This article reviews the pharmacokinetics of ivermectin in several domestic animal species.
González Canga
Aránzazu
A
Department of Biomedical Sciences, Veterinary Faculty, University of Leon, Spain. agonc@unileon.es
Sahagún Prieto
Ana M
AM
José Diez Liébana
M
M
Martínez
Nélida Fernández
NF
Vega
Matilde Sierra
MS
Vieitez
Juan J García
JJ
D000818:Animals; D000829:Animals, Domestic / Q000378:metabolism*; D000977:Antiparasitic Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002415:Cats / Q000378:metabolism; D002417:Cattle / Q000097:blood; D004285:Dogs / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006041:Goats / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects* / Q000502:physiology; D007559:Ivermectin / Q000493:pharmacokinetics*; D008657:Metabolic Clearance Rate / Q000502:physiology*; D012756:Sheep / Q000378:metabolism; D013045:Species Specificity; D013552:Swine / Q000378:metabolism
D000977:Antiparasitic Agents; D007559:Ivermectin