Synthesis and anti-inflammatory evaluation of methylene bridged benzofuranyl imidazo[2,1-b][1,3,4]thiadiazoles.
A series of 6-substituted and 5,6-disubstituted 2-(6-methyl-benzofuran-3-ylmethyl)-imidazo[2,1-b][1,3,4]thiadiazoles have been synthesized. The new compounds have been tested for their in vivo analgesic, anti-inflammatory activities. Qualitative SAR studies indicate that the chloro substitution in the imidazole ring and introduction of formyl group at C-5 position of the imidazole ring increased the anti-inflammatory and analgesic activity. All the newly synthesized compounds have been characterized by spectral data and ORTEP diagram of one of the intermediates 6-(4-chlorophenyl)-2-(6-methyl-benzofuran-3-ylmethyl)-5-morpholin-4-ylmethyl imidazo[2,1-b][1,3,4]thiadiazole is reported herein.
Jadhav
V B
VB
Department of Chemistry, Karnatak University, Dharwad-580 003, Karnataka, India.
Kulkarni
M V
MV
Rasal
V P
VP
Biradar
S S
SS
Vinay
M D
MD
D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D005260:Female; D007093:Imidazoles / Q000737:chemistry*; D008297:Male; D008745:Methylation; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D003432:Cross-Linking Reagents; D007093:Imidazoles; D013830:Thiadiazoles; C105430:benzofuran