title: Cytotoxic triterpenoid saponins from the roots of Platycodon grandiflorum.
abstract: Bioguided fractionation of the ethanol extracts obtained from Platycodon grandiflorum roots led to isolation of two new triterpenoid saponins, characterized as 3-O-beta-D-glucopyranosyl-2beta,12alpha,16alpha,23,24-pentahydroxyoleanane-28(13)-lactone (1) and 3-O-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-2beta,12alpha,16alpha,23alpha-tetrahydroxyoleanane-28(13)-lactone (2) by 1D- and 2D-NMR and MS techniques, as well as chemical means. Both compounds showed cytotoxic activity against human ECA-109 cells.
authors.affiliation: Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China. zhanglin@zju.edu.cn
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhen-Huan
authors.initials: ZH
authors.lastname: Liu
authors.forename: Jing-Kui
authors.initials: JK
authors.lastname: Tian
mesh_terms: D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007783:Lactones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000378:metabolism*; D031238:Platycodon; D012503:Saponins / Q000737:chemistry*; D013696:Temperature; D013729:Terpenes / Q000737:chemistry*
chemical_list: D007783:Lactones; D010936:Plant Extracts; D012503:Saponins; D013729:Terpenes