[Therapeutic response to plasmapheresis in four cases with obsessive-compulsive disorder and tic disorder triggered by streptococcal infections].
The acronym PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) has been assigned to a subgroup of patients experiencing pediatric onset obsessive-compulsive symptoms and tics as a result of autoimmune response to group A beta-hemolytic streptococcal infection. It has been hypothesized that an immune process initiated by infection affects the basal ganglia and causes neuropsychiatric symptoms. In cases with severe neuropsychiatric symptoms, the use of treatment strategies that interrupt the autoimmune process responsible for the pathogenesis of PANDAS, such as therapeutic plasmapheresis or intravenous immunoglobulin, has been proposed. In this paper, we discuss the effect of plasmapheresis treatment in 4 adult cases of obsessive-compulsive disorder and tic disorder triggered by streptococcal infections.
Beşiroğlu
Lütfullah
L
Yüzüncü Yil U Tip Fak., Psikiyatri AD., Van. lbesiroglu@yyu.edu.tr
Ağargün
Mehmet Yücel
MY
Ozbebit
Ozgür
O
Sözen
Mehmet
M
Dilek
Imdat
I
Güleç
Mustafa
M
D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D010956:Plasmapheresis; D013290:Streptococcal Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D013297:Streptococcus pyogenes; D013981:Tic Disorders / Q000150:complications / Q000175:diagnosis* / Q000628:therapy