Effects of Fusarium toxins on growth, humoral immune response and internal organs in weaner pigs, and the efficacy of apple pomace as an antidote.
A feeding trial using 220 weaner pigs which comprised two experimental series was conducted to investigate the effects of diets contaminated with the Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) and to test the hypothesis that apple pomace acts as an antidote to these mycotoxins. Two diets without contaminated wheat, containing either no pomace or 8% pomace, and two diets with naturally contaminated wheat (3.2 mg DON and 0.06 mg ZON, and 2.1 mg DON and 0.25 mg ZON per kg diet in series 1 and 2 respectively), containing either no pomace or 8% pomace were fed ad libitum for 5 weeks. Mycotoxin exposure lowered feed intake (p < 0.01) and growth (p = 0.05), and tended to decrease the energy conversion ratio (p = 0.06). Although the intake of apple pomace did not increase feed intake, it increased the growth rate (p = 0.04), mainly by restoring growth in the presence of mycotoxins (p = 0.08 for the interaction mycotoxin x pomace). In the first experimental series, the animals were immunized with a parvovirus vaccine. The percentage of seroconverting animals did not differ between the treatments (p = 0.56), which indicates that DON did not affect the humoral immune response. In the second experimental series, female piglets fed the contaminated diets had heavier uteri than piglets fed the uncontaminated diets (p < 0.01), regardless of pomace supplementation. The results show that pomace may alleviate the negative effect of DON on growth but does not counteract the hormonal effects of ZON.
Gutzwiller
A
A
Swiss Federal Research Station for Animal Production and Dairy Products (ALP), Posieux, Switzerland. andreas.gutzwiller@alp.admin.ch
Czeglédi
L
L
Stoll
P
P
Bruckner
L
L
D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D005506:Food Contamination / Q000032:analysis; D005670:Fusarium / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D027845:Malus / Q000737:chemistry*; D009929:Organ Size / Q000187:drug effects; D011897:Random Allocation; D013552:Swine / Q000254:growth & development* / Q000276:immunology*; D016896:Treatment Outcome; D014255:Trichothecenes / Q000008:administration & dosage / Q000633:toxicity*; D015025:Zearalenone / Q000008:administration & dosage / Q000633:toxicity
D014255:Trichothecenes; D015025:Zearalenone; C007262:deoxynivalenol