title: ORF virus infection in children: clinical characteristics, transmission, diagnostic methods, and future therapeutics.
abstract: Orf virus leads to self-limited, subacute cutaneous infections in children who have occupational or recreational contact with infected small ruminants. Breaches in the integument and contact with animals recently vaccinated for orf may be important risk factors in transmission. Common childhood behaviors are likely important factors in the provocation of significant contact (ie, bites) or in unusual lesion location (eg, facial lesions). Clinician recognition is important in distinguishing orf infection from life-threatening cutaneous zoonoses. Recently developed molecular techniques provide diagnostic precision and newer topical therapeutics may hasten healing.
authors.affiliation: Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. erlederman@yahoo.com
authors.forename: Edith R
authors.initials: ER
authors.lastname: Lederman
authors.forename: Connie
authors.initials: C
authors.lastname: Austin
authors.forename: Ingrid
authors.initials: I
authors.lastname: Trevino
authors.forename: Mary G
authors.initials: MG
authors.lastname: Reynolds
authors.forename: Holly
authors.initials: H
authors.lastname: Swanson
authors.forename: Bryan
authors.initials: B
authors.lastname: Cherry
authors.forename: Jennifer
authors.initials: J
authors.lastname: Ragsdale
authors.forename: John
authors.initials: J
authors.lastname: Dunn
authors.forename: Susan
authors.initials: S
authors.lastname: Meidl
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Howard
authors.initials: H
authors.lastname: Pue
authors.forename: Inger K
authors.initials: IK
authors.lastname: Damon
mesh_terms: D000293:Adolescent; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004474:Ecthyma, Contagious / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D009923:Orf virus / Q000302:isolation & purification*; D015047:Zoonoses / Q000821:virology*