title: Cellular reprogramming for the creation of patient-specific embryonic stem cells.
abstract: The success of somatic cell nuclear transfer in mammals has opened the possibility to dedifferentiate cells from a patient into embryonic stem cells and in doing so, potentially generate all different cells and tissues of the human body. These cells could be later transplanted to the same patient without immune rejection. Whereas this principle has been demonstrated in laboratory animals, it is yet to be shown to work in primates. Herein we discuss the probability of somatic cell nuclear transfer becoming a real therapeutic alternative as well as the potential emerging dedifferentiation approaches that may eventually replace it.
authors.affiliation: Cellular Reprogramming Laboratory, Michigan State University, Michigan, USA. cibelli@msu.edu
authors.forename: Jose B
authors.initials: JB
authors.lastname: Cibelli
authors.forename: Arif M
authors.initials: AM
authors.lastname: Kocabas
authors.forename: Zeki
authors.initials: Z
authors.lastname: Beyhan
authors.forename: Pablo J
authors.initials: PJ
authors.lastname: Ross
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002459:Cell Fusion; D053595:Embryonic Stem Cells / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D053652:Nuclear Transfer Techniques; D020411:Oligonucleotide Array Sequence Analysis; D009865:Oocytes / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D033581:Stem Cell Transplantation; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D016212:Transforming Growth Factor beta