Decoding of dopaminergic mesolimbic activity and depressive behavior.
Dopaminergic mesolimbic and mesocortical systems are involved in hedonia and motivation, two core symptoms of depression. However, their role in the pathophysiology of depression and their manipulation to treat depression has received little attention. Previously, we showed decreased limbic dopamine (DA) neurotransmission in an animal model of depression, Flinder sensitive line (FSL) rats. Here we describe a high correlation between phase-space algorithm of bursting-like activity of DA cells in the ventral tegmental area (VTA) and efficiency of DA release in the accumbens. This bursting-like activity of VTA DA cells of FSL rats is characterized by a low dimension complexity. Treatment with the antidepressant desipramine affected both the dimension complexity of cell firing in the VTA and rate of DA release in the accumbens, as well as alleviating depressive-like behavior. Our findings indicate the potential usefulness of monitoring limbic dopaminergic dynamics in combination with non-linear analysis. Decoding the functionality of the dopaminergic system may help in development of future antidepressant drugs.
Friedman
Alexander
A
Leslie Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel.
Deri
Ilana
I
Friedman
Yaakov
Y
Dremencov
Eliyahu
E
Goutkin
Sophia
S
Kravchinsky
Elizabeth
E
Mintz
Matti
M
Levi
Dino
D
Overstreet
David H
DH
Yadid
Gal
G
D000200:Action Potentials / Q000502:physiology; D000465:Algorithms; D000818:Animals; D001522:Behavior, Animal; D003866:Depressive Disorder / Q000503:physiopathology*; D004195:Disease Models, Animal; D004298:Dopamine / Q000502:physiology*; D004594:Electrophysiology; D008032:Limbic System / Q000502:physiology*; D008297:Male; D008959:Models, Neurological; D009714:Nucleus Accumbens / Q000502:physiology; D051381:Rats; D011922:Rats, Mutant Strains; D017207:Rats, Sprague-Dawley; D013550:Swimming; D009435:Synaptic Transmission; D017557:Ventral Tegmental Area / Q000502:physiology*
D004298:Dopamine