title: The utility of the Cambridge Behavioural Inventory in neurodegenerative disease.
abstract: We investigated the utility of the Cambridge Behavioural Inventory (CBI), a carer-completed questionnaire, in a large cohort with Parkinson's disease (PD) (n = 215). In a sub-cohort of 112 patients with PD, the CBI was found to be a valid instrument compared with the Neuropsychiatric Inventory, PDQ-39 and UPDRS, with high internal consistency. Furthermore, in the whole cohort, the CBI was sensitive to changes in behaviour with disease progression. Comparison between CBI scores in PD and other neurodegenerative diseases, including Huntington's disease (HD) (n = 75), Alzheimer's disease (AD) (n = 96) and frontal variant frontotemporal dementia (fvFTD) (n = 64), revealed distinct profiles for each disease. Predominant deficits were "sleep"' and "self care" in PD; "memory" in HD and AD; and "motivation" and "stereotypic behaviours" in fvFTD. The CBI is a robust, easy-to-use and valid instrument, which has the capacity to discriminate between neurodegenerative diseases, and may be of value in monitoring therapeutic interventions.
authors.affiliation: Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: C
authors.initials: C
authors.lastname: Wedderburn
authors.forename: H
authors.initials: H
authors.lastname: Wear
authors.forename: J
authors.initials: J
authors.lastname: Brown
authors.forename: S J
authors.initials: SJ
authors.lastname: Mason
authors.forename: R A
authors.initials: RA
authors.lastname: Barker
authors.forename: J
authors.initials: J
authors.lastname: Hodges
authors.forename: C
authors.initials: C
authors.lastname: Williams-Gray
mesh_terms: D000203:Activities of Daily Living / Q000145:classification / Q000523:psychology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis; D000704:Analysis of Variance; D017028:Caregivers / Q000523:psychology; D015331:Cohort Studies; D003704:Dementia / Q000175:diagnosis / Q000523:psychology; D003937:Diagnosis, Differential; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000523:psychology; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000523:psychology; D008609:Mental Status Schedule / Q000706:statistics & numerical data; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000523:psychology; D011594:Psychometrics / Q000706:statistics & numerical data; D011788:Quality of Life / Q000523:psychology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires