title: Susceptibility of schizophrenia and affective disorder not associated with loci on chromosome 6q in Han Chinese population.
abstract: BACKGROUND
  Several linkage studies across multiple population groups provide convergent support for susceptibility loci for schizophrenia - and, more recently, for affective disorder - on chromosome 6q. We explore whether schizophrenia and affective disorder have common susceptibility gene on 6q in Han Chinese population.
  
  
  METHODS
  In the present study, we genotyped 45 family trios from Han Chinese population with mixed family history of schizophrenia and affective disorder. Twelve short tandem repeat (STRs) markers were selected, which covered 102.19 cM on chromosome 6q with average spacing 9.29 cM and heterozygosity 0.78. The transmission disequilibrium test (TDT) was performed to search for susceptibility loci to schizophrenia and affective disorder.
  
  
  RESULTS
  The results showed STRs D6S257, D6S460, D6S1021, D6S292 and D6S1581 were associated with susceptibility to psychotic disorders. When families were grouped into schizophrenia and affective disorder group, D6S257, D6S460 and D6S1021, which map closely to the centromere of chromosome 6q, were associated with susceptibility to schizophrenia. Meanwhile, D6S1581, which maps closely to the telomere, was associated with susceptibility to affective disorder. But after correction of multiple test, all above association were changed into no significance (P > 0.05).
  
  
  CONCLUSIONS
  These results suggest that susceptibility of schizophrenia and affective disorder not associated with loci on chromosome 6q in Han Chinese population.
authors.affiliation: Department of Psychiatry, School of Medicine, Shanghai JiaoTong University, Shanghai, PRoC. fang-yr@online.sh.cn.
authors.forename: Zuowei
authors.initials: Z
authors.lastname: Wang
authors.forename: Yiru
authors.initials: Y
authors.lastname: Fang
authors.forename: Shunying
authors.initials: S
authors.lastname: Yu
authors.forename: Chengmei
authors.initials: C
authors.lastname: Yuan
authors.forename: Wu
authors.initials: W
authors.lastname: Hong
authors.forename: Zhenghui
authors.initials: Z
authors.lastname: Yi
authors.forename: Sanduo
authors.initials: S
authors.lastname: Jiang
authors.forename: R Kelsoe
authors.initials: RK
authors.lastname: John
authors.forename: Zucheng
authors.initials: Z
authors.lastname: Wang