Bioactive p-terphenyl derivatives from a Cordyceps-colonizing isolate of Gliocladium sp.
Gliocladinins A (1) and B (2), two new p-terphenyl derivatives, have been isolated from solid cultures of an isolate of Gliocladium sp. that colonizes Cordyceps sinensis. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. In standard disk assays, compounds 1 and 2 showed modest antimicrobial activity against Staphylococcus aureus (ATCC 6538). In addition, these compounds displayed inhibitory effects on the growth of two human tumor cell lines, HeLa and HCT116.
Guo
Huijuan
H
Key Laboratory of Systemic Mycology and Lichenology, Center for Bio-Energy and Industrial Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
Hu
Hejiao
H
Liu
Shuchun
S
Liu
Xingzhong
X
Zhou
Yuguang
Y
Che
Yongsheng
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032661:Cordyceps; D004354:Drug Screening Assays, Antitumor; D020462:Gliocladium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects*; D013730:Terphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018609:Tibet
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D013730:Terphenyl Compounds; C524247:gliocladinin A; C524248:gliocladinin B