title: Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia.
abstract: Toll-like receptors (TLR) recognize molecular structures associated with pathogens as well as host-derived components and initiate an inflammatory innate immune response. Microglia represent the resident immune host defense and are the major inflammatory cell type in the central nervous system (CNS). We show here that TLR2-deficient mice develop a decreased CNS injury compared to wild type mice in a model of focal cerebral ischemia. TLR2 mRNA is up-regulated in wild type mice during cerebral ischemia. In ischemic brains, TLR2 protein is expressed in lesion-associated microglia. Absence of TLR2 does not affect the recruitment of granulocytes to the infarct region. We conclude that TLR2 in microglia propagates stroke-induced CNS injury.
authors.affiliation: Center for Anatomy, Institute of Cell Biology and Neurobiology, Germany. seija.lehnardt@charite.de
authors.forename: Seija
authors.initials: S
authors.lastname: Lehnardt
authors.forename: Sabrina
authors.initials: S
authors.lastname: Lehmann
authors.forename: David
authors.initials: D
authors.lastname: Kaul
authors.forename: Katharina
authors.initials: K
authors.lastname: Tschimmel
authors.forename: Olaf
authors.initials: O
authors.lastname: Hoffmann
authors.forename: Sabine
authors.initials: S
authors.lastname: Cho
authors.forename: Christina
authors.initials: C
authors.lastname: Krueger
authors.forename: Robert
authors.initials: R
authors.lastname: Nitsch
authors.forename: Andreas
authors.initials: A
authors.lastname: Meisel
authors.forename: Joerg R
authors.initials: JR
authors.lastname: Weber
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D002545:Brain Ischemia / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D002544:Cerebral Infarction / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D002633:Chemotaxis / Q000235:genetics / Q000276:immunology; D004195:Disease Models, Animal; D004660:Encephalitis / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D020244:Infarction, Middle Cerebral Artery / Q000235:genetics / Q000276:immunology / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017628:Microglia / Q000276:immunology; D012333:RNA, Messenger / Q000378:metabolism; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D015854:Up-Regulation / Q000235:genetics / Q000276:immunology
chemical_list: D012333:RNA, Messenger; C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2