title: Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities.
abstract: A series of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs have been evaluated for their antagonist hormonal properties using the T47D cell-based alkaline phosphatase assay and the A549 cell-based functional assay. Some of the compounds showed highly potent, and more selective antiprogestational activity against antiglucocorticoid activity than mifepristone (RU 486).
authors.affiliation: Center for Organic and Medicinal Chemistry, RTI International, PO Box 12194, Research Triangle Park, NC 27709, USA. cjin@rti.org
authors.forename: Chunyang
authors.initials: C
authors.lastname: Jin
authors.forename: G
authors.initials: G
authors.lastname: Manikumar
authors.forename: John A
authors.initials: JA
authors.lastname: Kepler
authors.forename: C Edgar
authors.initials: CE
authors.lastname: Cook
authors.forename: George F
authors.initials: GF
authors.lastname: Allan
authors.forename: Margaret
authors.initials: M
authors.lastname: Kiddoe
authors.forename: Sheela
authors.initials: S
authors.lastname: Bhattacharjee
authors.forename: Olivia
authors.initials: O
authors.lastname: Linton
authors.forename: Scott G
authors.initials: SG
authors.lastname: Lundeen
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Sui
mesh_terms: D002460:Cell Line; D006801:Humans; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D011374:Progesterone / Q000037:antagonists & inhibitors*
chemical_list: D010080:Oxazoles; D011374:Progesterone