title: Pulmonary toxicity associated with erlotinib.
abstract: Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported. The adverse pulmonary effects of erlotinib are less well known. We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib. He had been found to have pathologic findings of usual interstitial pneumonia (UIP) on the resected lung cancer specimen prior to receiving erlotinib. This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD. Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.
authors.affiliation: Thoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. vinliu@stanford.edu
authors.forename: Vincent
authors.initials: V
authors.lastname: Liu
authors.forename: Dorothy A
authors.initials: DA
authors.lastname: White
authors.forename: Maureen F
authors.initials: MF
authors.lastname: Zakowski
authors.forename: William
authors.initials: W
authors.lastname: Travis
authors.forename: Mark G
authors.initials: MG
authors.lastname: Kris
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Ginsberg
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Miller
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Azzoli
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D000069347:Erlotinib Hydrochloride; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D047428:Protein Kinase Inhibitors / Q000009:adverse effects*; D011799:Quinazolines / Q000009:adverse effects*
chemical_list: D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000069347:Erlotinib Hydrochloride