title: [Docetaxel and gemcitabine combination in soft-tissue sarcomas treatment].
abstract: Soft-tissue sarcomas (STS) are usually sensitive to doxorubicine and/or ifosfamide. When tumors become refractory to these two drugs, chemotherapeutic options are limited. All the drugs tested generally yield occasional or negligible response, with response rates lower than 20% and a poor duration of response. No second-line chemotherapy have been clearly adopted. In vitro synergistic cytotoxicity has been reported with gemcitabine and docetaxel combination. Promising anti-tumor activity has been described with gemcitabine alone, docetaxel alone or these two drugs in combination These treatments were generally well tolerated. The best response have been observed in leiomyosarcomas. According to these results, gemcitabine and docetaxel combination might be of interest in STS. However, a phase III study is required to better evaluate the real advantage of this treatment.
authors.affiliation: Centre Jean Perrin, 58 rue Montalembert, 63000 Clermont-Ferrand. Olivier.bay@cjp.fr
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Bay
authors.forename: Aurélie
authors.initials: A
authors.lastname: Cabrespine
authors.forename: Olivier
authors.initials: O
authors.lastname: Gilliot
authors.forename: Corine
authors.initials: C
authors.lastname: Bailly
authors.forename: Catherine
authors.initials: C
authors.lastname: Vincent
authors.forename: Florence
authors.initials: F
authors.lastname: Mishellany
authors.forename: Pierre
authors.initials: P
authors.lastname: Gimbergues
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077143:Docetaxel; D006801:Humans; D012509:Sarcoma / Q000188:drug therapy*; D043823:Taxoids / Q000008:administration & dosage*; D000093542:Gemcitabine
chemical_list: D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D000093542:Gemcitabine