Relationship between diseases accompanied by tissue destruction and granulocytes with surface adrenergic receptors.
It is well-known that physiological phenomena and certain diseases, including neonatal granulocytosis, age-associated granulocytosis, periodontitis, pancreatitis, Crohn's disease, ulcerative colitis, hemorrhoids, endometriosis, and NSADs-enteritis, are accompanied by tissue destruction and granulocytosis. We investigated what is a key factor connecting tissue destruction and granulocytosis, attention being focused on adrenergic receptors on granulocytes and stress-induced sympathetic nerve stimulation. If we introduce the concept that "granulocytosis and subsequent tissue destruction are induced by sympathetic nerve stimulation," the mechanisms underlying many physiological phenomena and the etiology of several uncurable diseases in humans can be clearly understood.
Abo
Toru
T
Department of Immunology, Niigata University School of Medicine, Niigata, 951-8510, Japan. immunol2@med.niigata-u.ac.jp
Kawamura
Toshihiko
T
Kawamura
Hiroki
H
Tomiyama-Miyaji
Chikako
C
Kanda
Yasuhiro
Y
D000375:Aging / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D003681:Dehydration / Q000473:pathology; D006098:Granulocytes / Q000473:pathology / Q000502:physiology*; D006801:Humans; D007964:Leukocytosis / Q000139:chemically induced / Q000473:pathology*; D011941:Receptors, Adrenergic / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011941:Receptors, Adrenergic