Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia burgdorferi.
The BBK32 protein binds to host extracellular ligand fibronectin and contributes to the pathogenesis of Borrelia burgdorferi. Here we showed that expression of the BBK32 gene is influenced by multiple environmental factors and that its regulation is governed by the response regulator Rrp2 and RpoN-RpoS (sigma(54)-sigma(S)) sigma cascade in B. burgdorferi.
He
Ming
M
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Boardman
Bethany K
BK
Yan
Dalai
D
Yang
X Frank
XF
D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D025065:Borrelia burgdorferi / Q000235:genetics* / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D011485:Protein Binding; D051877:RNA Polymerase Sigma 54 / Q000235:genetics / Q000378:metabolism; D012808:Sigma Factor / Q000235:genetics / Q000378:metabolism; D013696:Temperature
D001426:Bacterial Proteins; D005353:Fibronectins; D012808:Sigma Factor; C106209:p35 antigen, Borrelia; C069567:sigma factor KatF protein, Bacteria; D051877:RNA Polymerase Sigma 54