title: Composite aortic valve graft replacement: mortality outcomes in a national registry.
abstract: BACKGROUND
  Composite aortic valve and root replacement (CVG) is a complex surgical procedure, but excellent center-specific outcomes are reported. We sought to report outcomes in a national cohort.
  
  
  RESULTS
  The United Kingdom Heart Valve Registry was interrogated for 1962 first-time CVG (and 37,102 aortic valve replacements [AVR] as a reference group) procedures from 1986 to 2004. We analyzed 30-day mortality, long-term survival (97.2% complete follow-up), and examined available risk factors for mortality using univariate and multivariate logistic regression analysis and causes of death. CVG patients were younger, received larger valve sizes and were more likely to be emergent than AVR patients. Overall 30-day mortality was 10.7% (CVG) and 3.6% (AVR). For CVG, multivariate analysis identified advanced age (> 70 years), concomitant coronary artery surgery, impaired left ventricular function, urgent or emergency status, prosthetic valve size < or = 23 mm and hospital activity volume < or = 8 procedures per annum as significant factors for 30-day mortality. Kaplan-Meier, 1-year, 5-year, 10-year and 20-year survival were 85.2%, 77.1%, 70% and 59.3%, respectively. The conditional (post-30-day) survival was similar to the AVR cohort.
  
  
  CONCLUSIONS
  These Registry data provide a unique national insight into CVG outcomes. After a higher initial mortality risk, CVG has equivalent conditional longer-term survival to AVR.
authors.affiliation: Department of Cardiothoracic Surgery, University Hospital Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Edgbaston, Birmingham-B15 2TH, UK.
authors.forename: Maninder S
authors.initials: MS
authors.lastname: Kalkat
authors.forename: Maria-Benedicta
authors.initials: MB
authors.lastname: Edwards
authors.forename: Keith M
authors.initials: KM
authors.lastname: Taylor
authors.forename: Robert S
authors.initials: RS
authors.lastname: Bonser
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve; D005260:Female; D006350:Heart Valve Prosthesis / Q000639:trends; D019918:Heart Valve Prosthesis Implantation / Q000401:mortality* / Q000639:trends*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D015996:Survival Rate / Q000639:trends*; D006113:United Kingdom / Q000453:epidemiology