Auto-reactive B cells in transgenic mice.
In order to understand how the natural occurrence of autoreactive B cells is controlled in normal individuals, and how self reactive B cells can escape this control during diverse clinical situations, many different transgenic mice have been generated expressing self reactive antibodies. In this review, we focus our attention on disease-associated self reactive transgenic models which show the variety of the tolerization mechanisms. The same transgenic lines are also used to analyse the effects of the autoimmune genetic background on the self reactive B cell fate, as well as to study the influence of infectious agents on the behaviour of the auto-reactive transgenic B cells.
Pasquali
Jean-Louis
JL
Laboratory of Immunopathology, INSERM U 737 and Université Louis Pasteur, Hopitaux Universitaires de Strasbourg, 67 091 Strasbourg, France. jean-louis.pasquali@chru-strasbourg.fr
Soulas-Sprauel
Pauline
P
Korganow
Anne-Sophie
AS
Martin
Thierry
T
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D008822:Mice, Transgenic / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens