Significance of zinc in nephrotoxicity of contrast media used in imaging diagnostics of the cardiovascular system.
Nephrotoxicity is an undesirable reaction of contrast media used in X-ray or magnetic resonance diagnostics. In addition to a direct toxic effect on renal tubules, the hemodynamic factor is considered to be the main cause of kidney damage and malfunction. The factors that increase the probability of a nephrotoxic effect of contrast media include oldage, diabetes, arterial hypertension, circulatory system insufficiency, neoplastic diseases, and prior kidney damage. Decreased serum zinc is observed in all those conditions. In this article, the influence of contrast media on zinc homeostasis and the possibility of a nephrotoxic reaction caused by these agents is discussed.
Tubek
Sławomir
S
Faculty of Physical Education and Physiotherapy, Institute of Technology, Opole, Prószkowska Street 76, Opole, 45-758, Poland. slawomir.tubek@hipokrates.org
Tubek
Iwona
I
D000818:Animals; D002319:Cardiovascular System / Q000033:anatomy & histology* / Q000187:drug effects / Q000378:metabolism; D003287:Contrast Media / Q000009:adverse effects*; D003952:Diagnostic Imaging; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism* / Q000503:physiopathology; D015032:Zinc / Q000009:adverse effects* / Q000097:blood / Q000378:metabolism
D003287:Contrast Media; D015032:Zinc