title: Non-transferrin-bound iron in plasma following administration of oral iron drugs.
abstract: Non-transferrin-bound iron (NTBI) was detected in serum samples from volunteers with normal iron stores or from patients with iron deficiency anaemia after oral application of pharmaceutical iron preparations. Following a 100 mg ferrous iron dosage, NTBI values up to 9 muM were found within the time period of 1-4 h after administration whereas transferrin saturation was clearly below 100%. Smaller iron dosages (10 and 30 mg) gave lower but still measurable NTBI values. The physiological relevance of this finding for patients under iron medication has to be elucidated.
authors.affiliation: Inst. für Biochemie und Molekularbiologie II: Molekulare Zellbiologie, Zentrum für Experimentelle Medizin Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Dresow
authors.forename: Doerte
authors.initials: D
authors.lastname: Petersen
authors.forename: Roland
authors.initials: R
authors.lastname: Fischer
authors.forename: Peter
authors.initials: P
authors.lastname: Nielsen
mesh_terms: D000284:Administration, Oral; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007501:Iron / Q000008:administration & dosage* / Q000097:blood* / Q000627:therapeutic use; D014168:Transferrin / Q000378:metabolism
chemical_list: D014168:Transferrin; D007501:Iron