[Vasopressin receptors: structure and stimulation by 1-deamino-arginine-vasotocin in rats].
In experiments on non-anesthetized female Wistar rats, it has been shown that injection of 1-deamino-arginine-vasotocin (1dAVT) increases sodium excretion and solute-free water reabsorption. Antagonists of V1-receptors (OPC-31260, Otsuka Pharmaceutical Co., Ltd., Japan) eliminates the effect water reabsorption whereas antagonist of V1-receptors (OPC-21268, Otsuka Pharmaceutical Co., Ltd., Japan) decreases the 1dAVT-dependent increase of Na+ and water excretion. A model of V1-receptors an a supposed topography of their interaction with 1dAVT are constructed.
Natochin
Iu V
IuV
Kanashkina
T A
TA
Mordvintsev
D
D
Shakhmatova
E I
EI
D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D005260:Female; D010880:Piperidines / Q000494:pharmacology; D020836:Protein Structure, Quaternary; D015363:Quinolones / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017483:Receptors, Vasopressin / Q000737:chemistry / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D014668:Vasotocin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D014867:Water / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D065092:Antidiuretic Hormone Receptor Antagonists; D010880:Piperidines; D015363:Quinolones; D017483:Receptors, Vasopressin; C523848:vasotocin, 1-deamino-arginine-; D014867:Water; C068644:OPC 21268; D012964:Sodium; D014668:Vasotocin