Non-transferrin-bound iron in plasma following administration of oral iron drugs.
Non-transferrin-bound iron (NTBI) was detected in serum samples from volunteers with normal iron stores or from patients with iron deficiency anaemia after oral application of pharmaceutical iron preparations. Following a 100 mg ferrous iron dosage, NTBI values up to 9 muM were found within the time period of 1-4 h after administration whereas transferrin saturation was clearly below 100%. Smaller iron dosages (10 and 30 mg) gave lower but still measurable NTBI values. The physiological relevance of this finding for patients under iron medication has to be elucidated.
Dresow
Bernd
B
Inst. für Biochemie und Molekularbiologie II: Molekulare Zellbiologie, Zentrum für Experimentelle Medizin Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Petersen
Doerte
D
Fischer
Roland
R
Nielsen
Peter
P
D000284:Administration, Oral; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007501:Iron / Q000008:administration & dosage* / Q000097:blood* / Q000627:therapeutic use; D014168:Transferrin / Q000378:metabolism
D014168:Transferrin; D007501:Iron