title: Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide.
abstract: A novel [18F]NF reagent and two novel radiochemical transformations have been developed: [18F]NFSi has been prepared from sodium dibenzenesulfonimide and reacted in the presence of silyl enol ethers and allylsilanes to deliver labelled fluorinated ketones and allylic fluorides respectively; the radiosynthesis of the fluorinated A ring of vitamin D3 has also been completed with success.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK OX1 3TA.
authors.forename: Harriet
authors.initials: H
authors.lastname: Teare
authors.forename: Edward G
authors.initials: EG
authors.lastname: Robins
authors.forename: Erik
authors.initials: E
authors.lastname: Arstad
authors.forename: Sajinder K
authors.initials: SK
authors.lastname: Luthra
authors.forename: Véronique
authors.initials: V
authors.lastname: Gouverneur
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D011874:Radiometry; D013449:Sulfonamides / Q000138:chemical synthesis*; D000096926:Benzenesulfonamides
chemical_list: D005462:Fluorine Radioisotopes; D013449:Sulfonamides; C523711:N-fluorobenzenesulfonimide; D000096926:Benzenesulfonamides