title: Estimation of mechanical heart valve cavitation in a pneumatic ventricular assist device.
abstract: In this study, we investigated the possibility of estimating the mechanical heart valve (MHV) cavitation intensity using the slope of the driving pressure (DP) just before valve closure in a pneumatic ventricular assist device. We installed a 23-mm Medtronic Hall valve at the inlet of our pneumatic ventricular assist device (VAD). Tests were conducted under physiologic pressures at heart rates ranging from 60 to 90 beats/min and cardiac outputs ranging from 4.5 to 6.7 l/min. The valve-closing velocity was measured with a CCD laster displacement sensor, and the images of MHV cavitation were recorded using a high-speed video camera. The cavitation cycle time (equal to the observed duration of the cavitation bubbles) was used as the MHV cavitation intensity. The valve-closing velocity increased as the heart rate increased. Most of the cavitation bubbles were observed near the valve stop, and the cavitation intensity increased as the heart rate increased. The slope of the DP at 20 ms before valve closure was used as an index of the cavitation intensity. There were differences in the slope of the DP between low and high heart rates, but the slope of the DP had a tendency to linearly increase with increasing valve-closing velocity.
authors.affiliation: Department of Artificial Organs, Research Institute, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita 565-8565, Japan. hslee@ri.ncvc.go.jp
authors.forename: Hwansung
authors.initials: H
authors.lastname: Lee
authors.forename: Eiki
authors.initials: E
authors.lastname: Akagawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Homma
authors.forename: Tomonori
authors.initials: T
authors.lastname: Tsukiya
authors.forename: Eisuke
authors.initials: E
authors.lastname: Tatsumi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Taenaka
mesh_terms: D001696:Biomechanical Phenomena; D019544:Equipment Failure Analysis / Q000379:methods; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D018056:Hemorheology; D006801:Humans; D008422:Materials Testing; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011475:Prosthesis Failure