title: Tumor induced hypercalcemia in a patient with mediastinal synovial sarcoma.
abstract: Tumor-induced hypercalcemia is a frequent complication of advanced cancers, but it has been rarely reported in patients with sarcoma. We report a 16 year-old boy presenting with polyuria, polydipsia and severe dehydration. Laboratory examination revealed severe hypercalcemia (serum calcium 23 mg/dl) which caused emaciation and was accompanied by low serum phosphorus and suppressed parathyroid hormone. Diagnostic imaging revealed a huge anterior mediastinal mass. Hypercalcemia was successfully treated with pamidronate, a bisphosphonate, and the patient underwent surgical resection. Pathological and immunohistochemical analyses confirmed a diagnosis of biphasic synovial sarcoma. To our knowledge, this is the first case of mediastinal synovial sarcoma presenting with hypercalcemia.
authors.affiliation: Department of Pediatric Endocrinology, Mashhad University of Medical Sciences, Mashhad, Iran. rvakili@hotmail.com
authors.forename: Rahim
authors.initials: R
authors.lastname: Vakili
authors.forename: Mehran
authors.initials: M
authors.lastname: Hiradfar
authors.forename: Nona
authors.initials: N
authors.lastname: Zabolinejad
authors.forename: Zahra
authors.initials: Z
authors.lastname: Badiei
mesh_terms: D000293:Adolescent; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging / Q000601:surgery; D000077268:Pamidronate; D013584:Sarcoma, Synovial / Q000097:blood* / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000077268:Pamidronate