title: Implication of PKC in the seasonal variation of the immune response of the hemocytes of Mytilus galloprovincialis Lmk. and its role in interleukin-2-induced nitric oxide synthesis.
abstract: The hemocytes are the cells responsible for the immune response in marine mollusks. The role of NO in processes related to the activation of the hemocytes has turned out evident over the late years. In the case of the mussel Mytilus galloprovincialis Lmk., hemocyte NO basal production varies throughout the year, showing a maximum in summer and a minimum in winter. IL-2 reverts the low winter NO basal production through a process mediated by cAMP-dependent protein kinase and by an apparent side effect of protein kinase C. The seasonal variation of NO production in the presence of the PKC inhibitor bisindolylmaleimide (BSM) allows suggesting a model in which PKC would modulate the activity of the enzymes responsible for nitric oxide production.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, Lugo, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Novas
authors.forename: Ramiro
authors.initials: R
authors.lastname: Barcia
authors.forename: Juan Ignacio
authors.initials: JI
authors.lastname: Ramos-Martínez
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006434:Hemocytes / Q000187:drug effects / Q000201:enzymology / Q000276:immunology*; D007211:Indoles / Q000494:pharmacology; D007376:Interleukin-2 / Q000502:physiology*; D008301:Maleimides / Q000494:pharmacology; D049878:Mytilus / Q000187:drug effects / Q000201:enzymology* / Q000276:immunology / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology*; D012621:Seasons
chemical_list: D007211:Indoles; D007376:Interleukin-2; D008301:Maleimides; D009569:Nitric Oxide; D011493:Protein Kinase C; C088060:bisindolylmaleimide