The role of interleukin-1 and the inflammasome in gout: implications for therapy.
Pope
Richard M
RM
Northwestern University Feinberg School of Medicine, and the Jesse Brown VA Medical Center, Chicago, Illinois 60611, USA. rmp158@northwestern.edu
Tschopp
Jürg
J
D000818:Animals; D015210:Arthritis, Gouty / Q000276:immunology* / Q000503:physiopathology; D002352:Carrier Proteins / Q000276:immunology; D003078:Colchicine / Q000494:pharmacology; D006073:Gout / Q000276:immunology; D006074:Gout Suppressants / Q000494:pharmacology; D006801:Humans; D033461:Hyperuricemia / Q000276:immunology; D007249:Inflammation / Q000503:physiopathology; D053583:Interleukin-1beta / Q000096:biosynthesis*; D008264:Macrophages / Q000187:drug effects; D009000:Monocytes / Q000187:drug effects; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology; D014527:Uric Acid / Q000378:metabolism
D002352:Carrier Proteins; D006074:Gout Suppressants; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D051193:Toll-Like Receptors; D014527:Uric Acid; D003078:Colchicine