DISC1 puts the brakes on neurogenesis.
The gene DISC1 (Disrupted-in-Schizophrenia 1) is a leading candidate gene for schizophrenia. In this issue, Duan et al. (2007) present evidence implicating DISC1 in the maturation and integration of newly generated neurons in the adult mouse hippocampus. Surprisingly, DISC1 appears to have opposite effects on neurogenesis during development and in adulthood.
Dranovsky
Alex
A
Departments of Psychiatry and Neuroscience, Columbia University, New York, NY 10032, USA. ad722@columbia.edu
Hen
Rene
R
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D019070:Cell Lineage; D002465:Cell Movement; D049109:Cell Proliferation; D048429:Cell Size; D003712:Dendrites / Q000378:metabolism; D018891:Dentate Gyrus / Q000378:metabolism / Q000473:pathology; D005838:Genotype; D006624:Hippocampus / Q000196:embryology / Q000254:growth & development / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D009024:Morphogenesis; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology; D013569:Synapses / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors
D002352:Carrier Proteins; C498794:Disc1 protein, mouse; C486015:Ndel1 protein, mouse; D009419:Nerve Tissue Proteins