title: Levodopa-induced modifications of prosody and comprehensibility in advanced Parkinson's disease as perceived by professional listeners.
abstract: The prosodic aspects of hypokinetic dysarthria in Parkinson's disease (PD) have been the focus of numerous reports. Few data on the effects of levodopa on prosody, more specifically on the effects on the variability of prosodic characteristics such as pitch, loudness and speech rate, are available in advanced PD. The relation between these characteristics and comprehensibility is currently unknown. These topics are the focus of the present report. Ten patients with advanced PD were evaluated, with and without medication, by four speech-language pathologists during a reading task. A significant improvement of variability in pitch and loudness was demonstrated after medication intake. Comprehensibility improved following medication administration. Results are compared with previous studies.
authors: Department of Oto-Rhino-Laryngology, Centre of Speech and Hearing Disorders, Ghent University Hospital, Ghent, Belgium. miet.deletter@ugent.be
authors: Miet
authors: M
authors: De Letter
authors: Patrick
authors: P
authors: Santens
authors: Irina
authors: I
authors: Estercam
authors: Georges
authors: G
authors: Van Maele
authors: Marc
authors: M
authors: De Bodt
authors: Paul
authors: P
authors: Boon
authors: John
authors: J
authors: Van Borsel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004401:Dysarthria / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008037:Linguistics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy*; D010479:Pergolide / Q000627:therapeutic use; D013018:Sound Spectrography; D013061:Speech Acoustics; D013065:Speech Intelligibility / Q000187:drug effects*; D013068:Speech Production Measurement; D014705:Verbal Behavior / Q000187:drug effects*
chemical_list: D000978:Antiparkinson Agents; D010479:Pergolide; D007980:Levodopa