title: Treatment of sympathomimetic induced intraventricular hemorrhage with intraventricular urokinase.
abstract: Intraventricular hemorrhage (IVH) occurred in a 32-year-old man following the use of both ephedrine and pseudoephedrine. Cerebral angiography and transcranial Doppler studies showed changes suggestive of vasculitis. We describe the management and investigations of a unique case of IVH. This patient was treated with ventriculostomy and intraventricular urokinase (UK). A favorable outcome was obtained with independent function at 10 weeks post hemorrhage. The use of intraventricular thrombolysis for drug-induced IVH has not previously been reported, although it has been shown to be a safe and potentially beneficial intervention.
authors: Division of Neurosciences Critical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. weziai@jhmi.edu
authors: Wendy C
authors: WC
authors: Ziai
authors: Antigone
authors: A
authors: Triantaphyllopoulou
authors: Alexander Y
authors: AY
authors: Razumovsky
authors: Daniel F
authors: DF
authors: Hanley