title: Anterior cingulate cortex modulates preparatory activation during certain anticipation of negative picture.
abstract: We studied the neural activation associated with anticipations of emotional pictures using functional magnetic resonance imaging (fMRI) by directly comparing certain with uncertain anticipation conditions. While being scanned with fMRI, healthy participants (n=18) were cued to anticipate and then perceive emotional stimuli having predictable (i.e., certain) emotional valences (i.e., positive and negative), given a preceding cue, as well as cued stimuli of uncertain valence (positive or negative). During anticipation of pictures with certain negative valence, activities of supracallosal anterior cingulate cortex, ventrolateral prefrontal cortex, insula, and amygdala were enhanced relative activity levels that for the uncertain emotional anticipation condition. This result suggests that these brain regions are involved in anticipation of negative images, and that their activity levels may be enhanced by the certainty of anticipation. Furthermore, the supracallosal anterior cingulate cortex showed functional connectivity with the insula, prefrontal cortex, and occipital cortex during the certain negative anticipation. These findings are consistent with an interpretation that top-down modulation, arising from anterior brain regions, is engaged in certain negative anticipation within the occipital cortex. It is thought that the limbic system involving the amygdala, ACC, and insula, engaged emotional processes, and that the input system involving the visual cortex entered an idling state.
authors: Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, Japan.
authors: Keiichi
authors: K
authors: Onoda
authors: Yasumasa
authors: Y
authors: Okamoto
authors: Shigeru
authors: S
authors: Toki
authors: Kazutaka
authors: K
authors: Ueda
authors: Kazuhiro
authors: K
authors: Shishida
authors: Akiko
authors: A
authors: Kinoshita
authors: Shinpei
authors: S
authors: Yoshimura
authors: Hidehisa
authors: H
authors: Yamashita
authors: Shigeto
authors: S
authors: Yamawaki
mesh_terms: D000328:Adult; D000339:Affect; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation / Q000379:methods; D011601:Psychophysics; D011930:Reaction Time / Q000502:physiology
chemical_list: D010100:Oxygen