Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families.
BACKGROUND
Atopic dermatitis develops as a result of complex interactions between several genetic and environmental factors. To date, 4 genome-wide linkage studies of atopic dermatitis have been performed in Caucasian populations, however, similar studies have not been done in Asian populations. The aim of this study was to identify chromosome regions linked to atopic dermatitis in a Japanese population.


METHODS
We used a high-density, single nucleotide polymorphism genotyping assay, the Illumina BeadArray Linkage Mapping Panel (version 4) comprising 5,861 single nucleotide polymorphisms, to perform a genome-wide linkage analysis of 77 Japanese families with 111 affected sib-pairs with atopic dermatitis.


RESULTS
We found suggestive evidence for linkage with 15q21 (LOD = 2.01, NPL = 2.87, P = .0012) and weak linkage to 1q24 (LOD = 1.26, NPL = 2.44, P = .008).


CONCLUSIONS
We report the first genome-wide linkage study of atopic dermatitis in an Asian population, and novel loci on chromosomes 15q21 and 1q24 linked to atopic dermatitis. Identification of novel causative genes for atopic dermatitis will advance our understanding of the pathogenesis of atopic dermatitis.
Enomoto
Hisako
H
Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan. ch0205531@md.tsukuba.ac.jp
Noguchi
Emiko
E
Iijima
Shigeruko
S
Takahashi
Takenori
T
Hayakawa
Kazuhito
K
Ito
Mikako
M
Kano
Toshiyuki
T
Aoki
Takeshi
T
Suzuki
Yoichi
Y
Koga
Minori
M
Tamari
Mayumi
M
Shiohara
Tetsuo
T
Otsuka
Fujio
F
Arinami
Tadao
T
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D003876:Dermatitis, Atopic / Q000208:ethnology* / Q000235:genetics*; D005192:Family Health; D005260:Female; D023281:Genomics; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide