Antiviral polysaccharides isolated from Hong Kong brown seaweed Hydroclathrus clathratus.
Two relatively pure polysaccharides H3-a1 and H3-b1 had been isolated from the brown seaweed Hydroclathrus clathratus. They were characterized by HPLC, ultraviolet scanning, gas chromatography, infrared spectroscopy and elemental analysis, and shown to be two different sulfated polysaccharides with different monosaccharide content, but both with high relative molecular mass. They contained some proteins and uronic acid respectively. The sulfate content and bioactivity of these polysaccharides varied during purification. The fractions derived from the hot water extract also exhibited low anticoagulant effect. This is the first time that the antiherpetic and anticoagulant activities were evaluated for the polysaccharides from the Hong Kong brown seaweed Hydroclathrus clathratus.
Wang
Hui
H
Medical College, Jinan University, Guangzhou 510632, China.
Ooi
Engchoon Vincent
EV
Ang
Put O
PO
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001681:Biological Assay; D002522:Chlorocebus aethiops; D002849:Chromatography, Gas / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification*; D012624:Seaweed / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D014709:Vero Cells; D014867:Water / Q000737:chemistry
D000925:Anticoagulants; D000998:Antiviral Agents; D010936:Plant Extracts; D011134:Polysaccharides; D014867:Water