title: Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21.
abstract: The goals of the human genome project did not include sequencing of the heterochromatic regions. We describe here an initial sequence of 1.1 Mb of the short arm of human chromosome 21 (HSA21p), estimated to be 10% of 21p. This region contains extensive euchromatic-like sequence and includes on average one transcript every 100 kb. These transcripts show multiple inter- and intrachromosomal copies, and extensive copy number and sequence variability. The sequencing of the "heterochromatic" regions of the human genome is likely to reveal many additional functional elements and provide important evolutionary information.
authors: Department of Genetic Medicine and Development, University of Geneva Medical School, and University Hospitals, 1211 Geneva, Switzerland. Robert.Lyle@medisin.uio.no
authors: Robert
authors: R
authors: Lyle
authors: Paola
authors: P
authors: Prandini
authors: Kazutoyo
authors: K
authors: Osoegawa
authors: Boudewijn
authors: B
authors: ten Hallers
authors: Sean
authors: S
authors: Humphray
authors: Baoli
authors: B
authors: Zhu
authors: Eduardo
authors: E
authors: Eyras
authors: Robert
authors: R
authors: Castelo
authors: Christine P
authors: CP
authors: Bird
authors: Sarantos
authors: S
authors: Gagos
authors: Carol
authors: C
authors: Scott
authors: Antony
authors: A
authors: Cox
authors: Samuel
authors: S
authors: Deutsch
authors: Catherine
authors: C
authors: Ucla
authors: Marc
authors: M
authors: Cruts
authors: Sophie
authors: S
authors: Dahoun
authors: Xinwei
authors: X
authors: She
authors: Frederique
authors: F
authors: Bena
authors: Sheng-Yue
authors: SY
authors: Wang
authors: Christine
authors: C
authors: Van Broeckhoven
authors: Evan E
authors: EE
authors: Eichler
authors: Roderic
authors: R
authors: Guigo
authors: Jane
authors: J
authors: Rogers
authors: Pieter J
authors: PJ
authors: de Jong
authors: Alexandre
authors: A
authors: Reymond
authors: Stylianos E
authors: SE
authors: Antonarakis
mesh_terms: D002891:Chromosomes, Human, Pair 21; D020451:Contig Mapping; D022041:Euchromatin / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011110:Polymorphism, Genetic
chemical_list: D022041:Euchromatin