Which genotype of MAO gene that the patients have are likely to be most susceptible to the symptoms of fibromyalgia?
The objective of this study was to analyze the genotype distributions and allele frequencies for the MAO-A and MAO-B polymorphism of the MAO gene among the patients with fibromyalgia syndrome (FS). One hundred and seven fibromyalgia patients and 90 unrelated healthy subjects were included into the study. Genomic DNA of 107 FS patients and 90 healthy control subjects were analyzed by polymerase chain reaction. Polymorphism of the MAO gene was: 1-1, 1-3, 3-3, 3-4. The "allele 3" had a 2.7 to 4.8-fold increased transcription activity than the "allele 1". The frequencies of the genotypes of the patients with FS and healthy controls were compared. Although no significant difference was found in genotypes of patients and controls (P = 0.0559), it is likely that "allele 3" could be a more riskful factor for FS than "allele 1" (P = 0.033). Fibromyalgia impact questionnaire was administered to FS group as well as control group. One of our findings is that, the patients whose genotype 3-3 may be mostly affected by the symptoms of FS. In conclusion, it seems plausible to say that MAOA-dependent metabolism of the biological amines may be partly related to high-activated MAO-A, allele 3, in the occurrence of FS among Turkish population.
Gürsoy
Savaş
S
School of Medicine, Department of Physical Medicine and Rehabilitation, Gaziantep University, Gaziantep, 27010, Turkey. gursoy@gantep.edu.tr
Erdal
Emin
E
Sezgin
Melek
M
Barlas
Ibrahim Omer
IO
Aydeniz
Ali
A
Alaşehirli
Belgin
B
Sahin
Günşah
G
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005356:Fibromyalgia / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013577:Syndrome; D014421:Turkey / Q000453:epidemiology
D008995:Monoamine Oxidase