RamB is an activator of the pyruvate dehydrogenase complex subunit E1p gene in Corynebacterium glutamicum.
In Corynebacterium glutamicum, the transcriptional regulator RamB negatively controls the expression of genes involved in acetate metabolism. Here we show that during growth in media containing glucose and in complex medium without glucose RamB activates expression of the aceE gene, encoding the E1p subunit of the pyruvate dehydrogenase complex. Thus, RamB functions both as repressor and as activator in C. glutamicum.
Blombach
Bastian
B
Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany.
Cramer
Annette
A
Eikmanns
Bernhard J
BJ
Schreiner
Mark
M
D000085:Acetates / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D001483:Base Sequence; D048230:Corynebacterium glutamicum / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D008969:Molecular Sequence Data; D030481:Pyruvate Dehydrogenase (Lipoamide) / Q000235:genetics* / Q000378:metabolism*
D000085:Acetates; D001426:Bacterial Proteins; D030481:Pyruvate Dehydrogenase (Lipoamide)