The ribosome filter redux.
The ribosome filter hypothesis postulates that ribosomes are not simply translation machines but also function as regulatory elements that differentially affect or filter the translation of particular mRNAs. On the basis of new information, we take the opportunity here to review the ribosome filter hypothesis, suggest specific mechanisms of action, and discuss recent examples from the literature that support it.
Mauro
Vincent P
VP
Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA. vmauro@scripps.edu
Edelman
Gerald M
GM
D000818:Animals; D006801:Humans; D014176:Protein Biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics*; D012270:Ribosomes / Q000235:genetics* / Q000378:metabolism* / Q000502:physiology
D012333:RNA, Messenger