title: Comparison of 99mTcO4(-) trans-splenic portal scintigraphy with per-rectal portal scintigraphy for diagnosis of portosystemic shunts in dogs.
abstract: OBJECTIVE
  To evaluate trans-splenic portal scintigraphy (TSPS) and per-rectal portal scintigraphy (PRPS) for diagnosis of congenital portosystemic shunts (CPSS) in dogs, and compare these results with surgical findings.
  
  
  METHODS
  Prospective, randomized cross over clinical trial.
  
  
  METHODS
  Dogs (n=42) with suspected CPSS.
  
  
  METHODS
  Dogs had TSPS and PRPS 48 hours apart; quantity of radionuclide administered was recorded. Three independent, blinded reviewers evaluated each scintigraphic study for study quality, shunt presence, number, and location of shunt termination (caudal vena cava, azygos vein). All dogs had exploratory celiotomy. Negative scintigraphic findings were confirmed with intraoperative mesenteric portography. Ameroid constrictors were placed on all extrahepatic CPSS, and hepatic biopsies were obtained.
  
  
  RESULTS
  TSPS was 100% sensitive and specific for diagnosis of CPSS and significantly (P<.05) more likely than PRPS to detect shunt number and termination. Interpretation was consistent between observers, and TSPS required significantly less radionuclide than PRPS.
  
  
  CONCLUSIONS
  TSPS was as sensitive as PRPS for detection of shunting vessels, and consistently yielded studies of higher quality, allowing detection of shunt number and location with consistent interpretation among radiologists.
  
  
  CONCLUSIONS
  TSPS provides information about shunt number and location, which allows improved surgical planning. Because it requires significantly less radionuclide, TSPS improves safety, allows for more comprehensive patient care, and earlier surgical intervention.
authors: Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, TN 37996-4544, USA. psura@utk.edu
authors: Patricia A
authors: PA
authors: Sura
authors: Karen M
authors: KM
authors: Tobias
authors: Federica
authors: F
authors: Morandi
authors: Gregory B
authors: GB
authors: Daniel
authors: Rita L
authors: RL
authors: Echandi
mesh_terms: D000818:Animals; D018592:Cross-Over Studies; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery; D004285:Dogs; D005260:Female; D006975:Hypertension, Portal / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery / Q000662:veterinary*; D008297:Male; D011168:Portal System / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000601:surgery; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011877:Radionuclide Imaging / Q000379:methods / Q000662:veterinary*; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013670:Sodium Pertechnetate Tc 99m; D013154:Spleen / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000601:surgery
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m