A novel nasal delivery system of a Chinese traditional medicine, Radix Bupleuri, based on the concept of ion-activated in situ gel.
The purpose of this study was to develop a nasal in situ gel system for Radix Bupleuri employing gellan gum as a polymer. Radix Bupleuri in situ gel containing 0.2 mL essential oil extracted from 450 g Radix Bupleuri, proper solubilizing agents and gellan gum (0.5% w/v) was prepared and characterized. The antipyretic effect produced by in situ gel formulation was investigated in fevered rabbits and compared to an intranasal solution. The resulting in situ gel was a clear and light-yellow liquid, with viscosity of 346 mPa x s and caproic acid content of 1.31 +/- 0.01 mg/mL. Intranasal administration of this preparation to fevered rabbits decreased body temperature markedly (1.1 degree C at the doses of oil from 1.5 g Bupleuri/body) and the effect could last for 20-30 h. The results suggest that Radix Bupleuri in situ gel can be greater effective than the solution in the treatment of fever.
Cao
Shi-Lei
SL
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China.
Chen
En
E
Zhang
Qi-Zhi
QZ
Jiang
Xin-Guo
XG
D000281:Administration, Intranasal; D000818:Animals; D001831:Body Temperature; D029972:Bupleurum / Q000737:chemistry; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D005334:Fever / Q000188:drug therapy; D020100:Hydrogels; D008297:Male; D008516:Medicine, Chinese Traditional; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D010938:Plant Oils / Q000737:chemistry / Q000302:isolation & purification*; D011135:Polysaccharides, Bacterial / Q000737:chemistry; D011749:Pyrogens / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D011817:Rabbits; D014783:Viscosity
C051274:Bupleurum root extract; D005079:Excipients; D020100:Hydrogels; D010936:Plant Extracts; D010938:Plant Oils; D011135:Polysaccharides, Bacterial; D011749:Pyrogens; C048288:gellan gum