title: Circulating hepatocyte growth factor level but not basic fibroblast growth factor level is elevated in angiography-proven symptomatic peripheral artery disease.
abstract: Circulating vasogenic factors may be up-regulated in response to ischemia to promote angiogenesis in patients with peripheral artery disease (PAD). Studies on this are limited in number and size, and results are inconsistent, especially regarding basic fibroblast growth factor (bFGF) level. From March 1999 to April 2004, all consecutive patients with lower limb PAD having serum samples at the time of intervention were recruited. The diameter of the primary PAD lesion had to be at least 70% stenotic at the lower limb artery. Control subjects, who underwent angiography, were free of PAD, coronary disease, and other major medical diseases. Serum samples were analyzed for circulating hepatocyte growth factor (HGF) and bFGF levels. Patients with PAD (n = 60) had higher circulating HGF levels (mean +/- SEM, 1,544 +/- 238 vs 970 +/- 129 pg/mL; P = .04) but similar bFGF distribution tertiles (P = .55) compared with control subjects (n = 30). Thirty-six patients with summed PAD lesion lengths exceeding 5 cm demonstrated a significantly higher circulating HGF level compared with control subjects (mean +/- SEM, 1,701 +/- 335 vs 970 +/- 129 pg/mL; P = .048). Patients with concurrent coronary artery disease tend to have a higher circulating HGF level (mean +/- SEM, 1,606 +/- 365 vs 970 +/- 129 pg/mL; P = .06) but not a higher bFGF level compared with control subjects. Circulating HGF level, but not bFGF level, is significantly elevated in patients with symptomatic angiographically documented PAD, especially in those with more extensive involvement.
authors: Cardiovascular Center, Taichung Veterans General Hospital, Taichung 407, Taiwan.
authors: Jiunn-Wen
authors: JW
authors: Lin
authors: Wayne Huey-Herng
authors: WH
authors: Sheu
authors: Wen-Jane
authors: WJ
authors: Lee
authors: Ying-Tsung
authors: YT
authors: Chen
authors: Tsun-Jui
authors: TJ
authors: Liu
authors: Chih-Tai
authors: CT
authors: Ting
authors: Wen-Lieng
authors: WL
authors: Lee
mesh_terms: D000368:Aged; D000792:Angiography; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005263:Femoral Artery; D016222:Fibroblast Growth Factor 2 / Q000097:blood; D005500:Follow-Up Studies; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D007083:Iliac Artery; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D016222:Fibroblast Growth Factor 2; D017228:Hepatocyte Growth Factor