Sodium tetramethoxyborate: an efficient catalyst for Michael additions of stabilized carbon nucleophiles.
Sodium tetramethoxyborate, easily prepared by reaction of inexpensive sodium borohydride with methanol, possesses a suitable combination of a Lewis base and a Lewis acid to catalyze Michael reactions at room temperature under practically neutral conditions. This reaction provides good to excellent yields of Michael addition products from a broad scope of Michael donor and Michael acceptor reagents.
Campaña
Araceli G
AG
Department of Organic Chemistry, Faculty of Sciences, Campus Fuentenueva s/n, University of Granada, E-18071 Granada, Spain.
Fuentes
Noelia
N
Gómez-Bengoa
Enrique
E
Mateo
Cristina
C
Oltra
J Enrique
JE
Echavarren
Antonio M
AM
Cuerva
Juan M
JM