title: Fine needle cytology of complex thyroid nodules.
abstract: OBJECTIVE
  To evaluate whether a preliminary aspiration (ASP) of the cystic component and/or using spinal needles in complex thyroid nodules (CTN) could improve the adequacy of cytological sampling.
  
  
  METHODS
  Between January 2004 and December 2006, 386 consecutive patients with CTN were enrolled in this prospective investigation. Ultrasound (US) fine needle aspiration cytology (FNAC) of the solid component of the nodule (one nodule per patient) was performed using two different 25 gauge needles, with (Yale Spinal, YS) or without (Neolus, NS) a stylet, in alternate sequence on consecutive patients. In addition, a subgroup of patients presenting larger cystic component (approximately 50%) was submitted to total aspiration of the cystic component (ASP+) or not submitted (ASP-) before US-FNAC, in alternate sequence within each needle type group. All the samplings were performed by a single endocrinologist.
  
  
  RESULTS
  Adequate specimens were observed in 163 (84.5%) and 183 (94.8%) nodules investigated by NS and YS respectively. Sampling with the stylet needle was associated with an overall significant reduction of non-diagnostic specimens (15.5% vs 5.2% by NS and YS respectively, P < 0.001). The favourable result obtained with YS was independent from preliminary aspiration of the cystic component (ASP+: 14.8% vs 5.7% by NS and YS; ASP-: 16.2% vs 4.8%, not significant). A logistic regression analysis, taking into account nodule size and presence of intranodal vascularity at eco-colour evaluation of the solid component, confirmed that needle type was the only significant predictor of successful sampling (odds ratio 3.6 (95% confidence interval 1.7-7.6), P < 0.001).
  
  
  CONCLUSIONS
  Our data show that adopting stylet needles to perform FNAC in CTN may significantly improve the percentage of adequate sampling. On the other hand, preliminary aspiration of CTN with large cystic component does not add any advantage.
authors: Internal Medicine and Endocrinology Unit, Department of Medical and Surgical Sciences, c/o 2 Medicina Spedali Civili di Brescia, University of Brescia, Piazzale Spedali Civili number 1, 25100 Brescia, Italy. cappelli@med.unibs.it
authors: C
authors: C
authors: Cappelli
authors: I
authors: I
authors: Pirola
authors: M
authors: M
authors: Castellano
authors: E
authors: E
authors: Gandossi
authors: E
authors: E
authors: De Martino
authors: A
authors: A
authors: Delbarba
authors: B
authors: B
authors: Agosti
authors: A
authors: A
authors: Tironi
authors: E Agabiti
authors: EA
authors: Rosei
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle / Q000009:adverse effects / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D016606:Thyroid Nodule / Q000175:diagnosis* / Q000473:pathology*; D018084:Ultrasonography, Interventional / Q000009:adverse effects / Q000379:methods*