title: Subcortical hyperintensities are associated with cognitive decline in patients with mild cognitive impairment.
abstract: OBJECTIVE
  It has been suggested that subcortical lesions may influence cognitive performances at early stages of cognitive impairment but not in late stages of dementia. We aimed to test whether cognitive decline is associated with subcortical hyperintensities in patients with mild cognitive impairment (MCI).
  
  
  METHODS
  We included 170 consecutive MCI patients (mean follow-up, 3.8+/-1.6 years). We assessed subcortical hyperintensities on a baseline magnetic resonance imaging scan with a semiquantitative rating scale. The mean annual cognitive decline was calculated with the Mini-Mental State Examination and the Dementia Rating Scale at baseline and the end of follow-up.
  
  
  RESULTS
  Compared with patients whose cognitive performances remained stable or improved during follow-up, patients whose cognitive performances declined often had a larger amount (greater than the median of the distribution) of periventricular (PVH) (P=0.0005) and white-matter (P=0.02) hyperintensities. The rate of cognitive decline was higher with increasing PVH: mean change in the Mini-Mental State Examination score=0.16 vs -0.66 points/year in patients with PVH in the first versus third tertile (P=0.0002). The rate of decline in executive functioning was also higher with increasing PVH: mean change in the Dementia Rating Scale initiation subscore=-0.05 vs -1.42 points/year in patients with PVH in the first versus third tertile (P=0.04). These associations were independent of vascular risk factors, temporal lobe atrophy, and MCI subtype and were stronger in patients with baseline executive dysfunction.
  
  
  CONCLUSIONS
  White-matter hyperintensities and especially PVH were significantly associated with cognitive decline in MCI patients. This result was independent of the MCI subtype but stronger in cases of executive dysfunction at baseline.
authors: Department of Neurology, Memory Center, Lille University Hospital, Lille, France.
authors: Stéphanie
authors: S
authors: Debette
authors: Stéphanie
authors: S
authors: Bombois
authors: Amélie
authors: A
authors: Bruandet
authors: Xavier
authors: X
authors: Delbeuck
authors: Samuel
authors: S
authors: Lepoittevin
authors: Christine
authors: C
authors: Delmaire
authors: Didier
authors: D
authors: Leys
authors: Florence
authors: F
authors: Pasquier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology; D054022:Cerebrum / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D003072:Cognition Disorders / Q000453:epidemiology* / Q000503:physiopathology / Q000523:psychology; D015897:Comorbidity; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008833:Microcirculation / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology