title: Clinical factors associated with long-term mortality following vascular surgery: outcomes from the Coronary Artery Revascularization Prophylaxis (CARP) Trial.
abstract: BACKGROUND
  Preoperative cardiac risks and clinical indications for vascular surgery are both important determinants of outcome following a vascular operation. Using the nonrandomized cohort from the Coronary Artery Revascularization Prophylaxis (CARP) Trial, we analyzed the predictors of outcome based on the presenting vascular problem and prevalence of comorbid conditions and cardiac risks.
  
  
  RESULTS
  Between March 1, 1999 and February 28, 2003, 4414 patients were ineligible for randomization in the CARP Trial and their survival was retrieved through the BIRLS system (the Department of Veterans Affairs Beneficiary Identification and Records Locator Subsystem). Surgical indications were either an abdominal aortic aneurysm (N = 1598) or lower extremity ischemia for claudication (N = 1116), rest pain (N = 670), or tissue loss (N = 1030). Patients were screened for major cardiac risks that included a history of angina, congestive heart failure, myocardial infarction, ventricular arrhythmias, pathological q-waves, and diabetes. The absence of multiple cardiac risks, as the sole reason for exclusion from randomization, occurred in 2314 (52.4%) screened patients and their probability of survival at 2.5-year post-surgery was 0.88. This was better than the survival of the remaining excluded patients (N = 2100), which was 0.75 (P < .0001) and the randomized cohort (N = 462), which was 0.80 (P < .0001). By Cox regression analysis, urgent surgery, congestive heart failure, ventricular arrhythmias and creatinine >3.5 mg/dL were significantly associated with long-term postoperative mortality.
  
  
  CONCLUSIONS
  Patients without multiple cardiac risks or comorbid conditions have a good outcome following elective vascular surgery. Urgent surgery, creatinine >3.5 mg/dL, congestive heart failure, and ventricular arrhythmias are identifiers of a poor long-term outcome and may justify aggressive strategies for risk-stratification in the postoperative period.
authors: Division of Cardiology, VA Medical Center, Minneapolis, MN 55417, USA. mcfal00l@tc.umn.edu
authors: Edward O
authors: EO
authors: McFalls
authors: Herbert B
authors: HB
authors: Ward
authors: Thomas E
authors: TE
authors: Moritz
authors: Fred
authors: F
authors: Littooy
authors: Steve
authors: S
authors: Santilli
authors: Joseph
authors: J
authors: Rapp
authors: Greg
authors: G
authors: Larsen
authors: Domenic J
authors: DJ
authors: Reda
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007511:Ischemia / Q000601:surgery*; D053208:Kaplan-Meier Estimate; D007866:Leg / Q000098:blood supply*; D008297:Male; D016016:Proportional Hazards Models; D015996:Survival Rate; D014656:Vascular Surgical Procedures / Q000401:mortality*