Risk factors for rhabdomyolysis following doxylamine overdose.
The objective of this prospective study was to identify risk factors for developing rhabdomyolysis in patients with doxylamine overdose. Patients who were admitted to a university teaching hospital between July 2000 and September 2005 due to doxylamine overdose were recruited. Demographic information, clinical variables, and laboratory data were investigated. Twenty-seven (M/F 12/15, age 33.2 +/-13.1 years) patients were enrolled. Sixteen (59%) of 27 patients developed rhabdomyolysis and three (19%) of 16 patients with rhabdomyolysis also developed acute renal failure. Patients who developed rhabdomyolysis differed from those who did not in the amount of doxylamine ingested, initial serum creatitnine and arterial pH. In multivariate regression analysis, the only reliable predictor of rhabdomyolysis was the amount of doxylamine ingested (P = 0.039). The amount of doxylamine ingested (>/= 20 mg/kg) predicted the development of rhabdomyolysis with a sensitivity of 81%, a specificity of 82%, a positive predictive value of 87%, and a negative predictive value of 75%.In conclusion, rhabdomyolysis following doxylamine overdose was common, occurring in 87% of patients who ingested more than 20 mg/kg. The amount of doxylamine ingested was the only reliable predictor for developing rhabdomyolysis following doxylamine overdose.
Jo
Young-Il
YI
Division of Nephrology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Song
Jong-Oh
JO
Park
Jung-Hwan
JH
Koh
Soon-Young
SY
Lee
Seung-Min
SM
Seo
Tae-Ho
TH
Lee
Jong-Ho
JH
D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004319:Doxylamine / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D006633:Histamine Antagonists / Q000506:poisoning*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012206:Rhabdomyolysis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D012307:Risk Factors; D012680:Sensitivity and Specificity
D006633:Histamine Antagonists; D004319:Doxylamine; D003404:Creatinine