title: Clinical and diagnostic imaging findings predict anesthetic complications in children presenting with malignant mediastinal masses.
abstract: BACKGROUND
  The presence of a mediastinal mass in a child poses significant anesthesia-related risks including death. To optimize outcome clinicians must be able to predict which patients are at highest risk of anesthetic complications.
  
  
  METHODS
  We conducted a retrospective review of 118 pediatric patients who presented with mediastinal masses. We investigated their medical records for clinical symptoms and signs at presentation and reviewed their chest radiographs, computed tomography scans, and echocardiograms and electrocardiograms when available. We then conducted analyses to identify clinical and diagnostic imaging features associated with anesthesia-related complications.
  
  
  RESULTS
  Eleven of 117 [9.4%, 95% confidence interval (CI) 4.1-14.7%] patients experienced an anesthesia-related complication. Four preoperative features were significantly associated with anesthetic complications: orthopnea (P = 0.033, odds ratio (OR) 5.31, 95% CI, 1.15-24.56), upper body edema (P = 0.035, OR 8.00, 95% CI, 1.16-55.07), great vessel compression (P = 0.037, OR 5.41, 95% CI, 1.11-26.49), and main-stem bronchus compression (P = 0.044, OR 5.11, 95% CI, 1.05-24.92). The presence of pleural effusion (P = 0.060, OR 4.53, 95% CI, 0.94-21.96) or tracheal compression (P = 0.061, OR 5.09, 95% CI, 0.93-27.81) also appeared to be risk factors. Although the rate of anesthesia-related complications detected in our cohort was comparable with that found in earlier studies, the events were less severe.
  
  
  CONCLUSIONS
  Patients who present with orthopnea, upper body edema, great vessel compression and main stem bronchus compression are at risk of anesthesia-related complications. The low severity of complications in our series may reflect a combination of factors: use of the least invasive method such as interventional radiology to obtain tissue for diagnosis, completion of a thorough preoperative assessment and minimal anesthesia intervention.
authors: Division of Anesthesiology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA. doralina.anghelescu@stjude.org
authors: Doralina L
authors: DL
authors: Anghelescu
authors: Laura L
authors: LL
authors: Burgoyne
authors: Tiebin
authors: T
authors: Liu
authors: Chin-Shang
authors: CS
authors: Li
authors: Ching-Hon
authors: CH
authors: Pui
authors: Melissa M
authors: MM
authors: Hudson
authors: Wayne L
authors: WL
authors: Furman
authors: John T
authors: JT
authors: Sandlund
mesh_terms: D000293:Adolescent; D000328:Adult; D000758:Anesthesia / Q000009:adverse effects* / Q000379:methods; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007223:Infant; D007431:Intraoperative Complications / Q000453:epidemiology* / Q000517:prevention & control; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D016015:Logistic Models; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D008499:Medical Records; D016066:Pleural Effusion, Malignant / Q000000981:diagnostic imaging / Q000209:etiology; D011183:Postoperative Complications / Q000453:epidemiology* / Q000517:prevention & control; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed