title: Development of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy.
abstract: It has been hypothesized that specific immunotherapy (SIT) significantly decreases the development of new allergen sensitizations in mono-sensitized patients. In this study, we evaluated the effect of SIT on the development of new allergen sensitizations in 129 asthmatic children mono-sensitized to house dust mite. SIT was accepted by only 70 of them (SIT group). The remaining 59 children were treated only with medication (control group). At the end of the study we found that 33% of all patients developed new sensitizations. Surprisingly, the prevalence of new sensitizations was significantly higher in the SIT group (45.5%) than in the control group (18.1 %). Ash tree (Fraxinus excelsior), Olive and Meadow fescue (Festuca elatior) were the most common allergens responsible for the new sensitizations. We conclude that SIT did not prevent the onset of new sensitizations in asthmatic children mono-sensitized to house dust mite.
authors: Department of Pediatrics, Division of Allergy and Pulmonology, Aegean University School of Medicine, Turkey. figen.gulen@ege.edu.tr
authors: Figen
authors: F
authors: Gulen
authors: Dost
authors: D
authors: Zeyrek
authors: Demet
authors: D
authors: Can
authors: Serdar
authors: S
authors: Altinoz
authors: Huseyin
authors: H
authors: Koksoy
authors: Esen
authors: E
authors: Demir
authors: Remziye
authors: R
authors: Tanac
mesh_terms: D000485:Allergens; D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000628:therapy*; D015984:Causality; D002648:Child; D003888:Desensitization, Immunologic; D004391:Dust / Q000276:immunology; D005260:Female; D031751:Festuca / Q000276:immunology; D031661:Fraxinus / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008297:Male; D039981:Pyroglyphidae / Q000276:immunology*; D012882:Skin Tests
chemical_list: D000485:Allergens; D004391:Dust