title: The use of body mass index to predict pathological stage in patients with clinically localized prostate cancer.
abstract: BACKGROUND
  To investigate whether body mass index (BMI) is an independent risk factor for nonorgan-confined disease in patients with clinically localized prostate cancer.
  
  
  METHODS
  Overall, 735 patients undergoing radical prostatectomy formed the study cohort. Pathological and clinical factors with special emphasis to BMI were used to determine a model for the prediction of nonorgan-confined disease.
  
  
  RESULTS
  359 patients had pathologically nonorgan-confined prostate cancer. These patients showed a significantly higher BMI than those with organ-confined disease (26.7 vs. 26.2; p = 0.0012). In multivariate analysis, age (p = 0.049), prostate-specific antigen (PSA) (p < 0.001), clinical stage (p < 0.001), prostatectomy grade (p < 0.001), and BMI (p = 0.004) were independent risk factors for nonorgan-confined disease. In patients with a serum PSA between 10.1 and 20 ng/ml only prostatectomy grade (p < 0.001) and BMI (p = 0.005) remained independent predictors.
  
  
  CONCLUSIONS
  Patients with nonorgan-confined disease showed a significantly higher BMI than those with organ-confined stages. Moreover, BMI was an independent predictor for nonorganconfined prostate cancer. This knowledge might be helpful in patient counseling to choose between various options for the treatment of clinically localized prostate cancer.
authors: Department of Urology, Medical University of Graz, Austria.
authors: Karl
authors: K
authors: Pummer
authors: Haro
authors: H
authors: Stettner
authors: Herbert
authors: H
authors: Augustin
authors: Richard
authors: R
authors: Zigeuner
authors: Helga
authors: H
authors: Habermann
authors: Luigi
authors: L
authors: Schips
authors: Ildiko
authors: I
authors: Riedler
authors: Harald
authors: H
authors: Trummer
authors: Kathrin
authors: K
authors: Lipsky
authors: Stephen B
authors: SB
authors: Williams
mesh_terms: D000886:Anthropometry / Q000379:methods*; D001317:Austria / Q000453:epidemiology; D015992:Body Mass Index; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D012044:Regression Analysis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013223:Statistics as Topic