Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.
There is a renewed interest in the ultimate role of fatty acid synthase (FASN)--a key lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids--in cancer pathogenesis. Tumour-associated FASN, by conferring growth and survival advantages rather than functioning as an anabolic energy-storage pathway, appears to necessarily accompany the natural history of most human cancers. A recent identification of cross-talk between FASN and well-established cancer-controlling networks begins to delineate the oncogenic nature of FASN-driven lipogenesis. FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.
Menendez
Javier A
JA
Translational Research Unit, Catalan Institute of Oncology (ICO), Health Services Division of Catalonia, Girona Biomedical Research Institute (IdIBGi), Medical Oncology, Josep Trueta University Hospital of Girona, 17,007 Girona, Catalonia, Spain.
Lupu
Ruth
R
D055372:AMP-Activated Protein Kinases; D000970:Antineoplastic Agents / Q000494:pharmacology; D002278:Carcinoma in Situ / Q000473:pathology; D016923:Cell Death / Q000235:genetics; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005227:Fatty Acids / Q000096:biosynthesis; D019398:Genes, BRCA1; D005947:Glucose / Q000378:metabolism; D006801:Humans; D050155:Lipogenesis / Q000235:genetics*; D009097:Multienzyme Complexes / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics; D010641:Phenotype; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051780:Sterol Regulatory Element Binding Protein 1 / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics
D000970:Antineoplastic Agents; D005227:Fatty Acids; D009097:Multienzyme Complexes; D009687:Nuclear Proteins; D051780:Sterol Regulatory Element Binding Protein 1; C051065:THRSP protein, human; D014157:Transcription Factors; D064429:Fatty Acid Synthases; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose