title: Intrahepatic cholangiocarcinoma with old infestation of Schistosoma japonicum: report of a case.
abstract: We report a rare case of intrahepatic cholangiocarcinoma associated with old infestation of Schistosoma japonicum. The patient was a 76-year-old Japanese man who had lived his childhood in an endemic area of this parasite. He presented with jaundice and computed tomography showed a 4-cm, hypodense tumor in segment VIII of the liver. Microscopically, the resected mass was composed of well-differentiated adenocarcinoma cells. Fibrosis and inflammation were seen around the dilated peripheral portal veins embolized with dead S. japonicum eggs. Our search of the literature found only one other case of cholangiocarcinoma coincident with S. japonicum, suggesting that it is not a risk factor for cholangiocarcinoma, although the inflammation and fibrosis caused by the S. japonicum eggshells may predispose to carcinogenesis. However, there is no evidence supporting this hypothesis. More data are necessary to evaluate the differences in clinicopathological findings between cholangiocarcinoma concomitant with S. japonicum and the usual type of cholangiocarcinoma.
authors: Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan.
authors: Tomotaka
authors: T
authors: Akatsu
authors: Motohide
authors: M
authors: Shimazu
authors: Masahiro
authors: M
authors: Shinoda
authors: Shigeyuki
authors: S
authors: Kawachi
authors: Minoru
authors: M
authors: Tanabe
authors: Koichi
authors: K
authors: Aiura
authors: Masakazu
authors: M
authors: Ueda
authors: Kaori
authors: K
authors: Kameyama
authors: Michiie
authors: M
authors: Sakamoto
authors: Masaki
authors: M
authors: Kitajima
authors: Yuko
authors: Y
authors: Kitagawa
mesh_terms: D000368:Aged; D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D006801:Humans; D008109:Liver Diseases, Parasitic / Q000150:complications* / Q000188:drug therapy; D008297:Male; D011223:Praziquantel / Q000627:therapeutic use; D012307:Risk Factors; D012549:Schistosoma japonicum
chemical_list: D000977:Antiparasitic Agents; D011223:Praziquantel