title: [Infectious complications in necrotizing pancreatitis].
abstract: Patients with CT evidence of more than 50 % necrosis, or an increased CRP or procalcitonin are at risk of developing severe pancreatitis and septic complications and should be monitored in an intensive care unit. ERCP and sphincterotomy are indicated in patients with biliary pancreatitis and impacted gall stones, biliary sepsis, or obstructive jaundice. In septic patients with necrotizing pancreatitis, a FNA should be performed for differentiation of sterile and infected pancreatic necrosis. Adequate volume resuscitation and analgesic treatment are the most important treatment of acute pancreatitis. Antibiotic prophylaxis reduces septic complications in severe necrotizing pancreatitis and should be started early. Surgical therapy is indicated in patients with infected pancreatic necrosis. The surgical technique of choice is open necrosectomy with postoperative closed lavage of the lesser sac.
authors: Chirurgische Universitätsklinik Heidelberg, Abteilung für Allgemeine und Viszerale Chirurgie, Heidelberg, Germany.
authors: J
authors: J
authors: Werner
authors: M W
authors: MW
authors: Büchler
mesh_terms: D019072:Antibiotic Prophylaxis; D044963:Biopsy, Fine-Needle; D002097:C-Reactive Protein / Q000378:metabolism; D002760:Cholangiopancreatography, Endoscopic Retrograde; D006801:Humans; D010179:Pancreas / Q000473:pathology; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D012086:Reoperation; D018805:Sepsis / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D016717:Sphincterotomy, Endoscopic; D015996:Survival Rate; D007507:Therapeutic Irrigation
chemical_list: D002097:C-Reactive Protein