Laponite-based nanohybrid for enhanced solubility and controlled release of itraconazole.
Laponite, a form of layered aluminosilicates, and itraconazole, a water insoluble drug, were hybridized through an interfacial reaction at the boundary between water and a water-immiscible liquid. The reaction was carried out under a controlled pH to maintain both physical and chemical stability of the drug. The X-ray diffraction patterns and spectroscopic analyses indicated that itraconazole was intercalated into the interlayer space of clay with a lateral monolayer structure. No significant chemical structural change of itraconazole was seen through the formation of the hybrid. The hybrid system exhibited enhanced solubility and controlled release of itraconazole. The released amount of itraconazole could be controlled in the range from 18 to 75%, depending on the kinds of cations in the release media.
Jung
Hyun
H
Center for Intelligent Nano-Bio Materials, Division of Nanosciences and Department of Chemistry, Ewha Womans University, Seoul 120-750, Republic of Korea.
Kim
Hyun-Mi
HM
Choy
Young Bin
YB
Hwang
Seong-Ju
SJ
Choy
Jin-Ho
JH
D000935:Antifungal Agents / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004355:Drug Stability; D005079:Excipients; D017964:Itraconazole / Q000008:administration & dosage* / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D017640:Silicates / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D000935:Antifungal Agents; D003692:Delayed-Action Preparations; D005079:Excipients; D017640:Silicates; D017964:Itraconazole; C033214:Smectite; C524813:laponite