Rogue athletes and recombinant DNA technology: challenges for doping control.
The quest for athletic excellence holds no limit for some athletes, and the advances in recombinant DNA technology have handed these athletes the ultimate doping weapons: recombinant proteins and gene doping. Some detection methods are now available for several recombinant proteins that are commercially available as pharmaceuticals and being abused by dopers. However, researchers are struggling to come up with efficient detection methods in preparation for the imminent threat of gene doping, expected in the 2008 Olympics. This Forum article presents the main detection strategies for recombinant proteins and the forthcoming detection strategies for gene doping as well as the prime analytical challenges facing them.
Azzazy
Hassan M E
HM
Department of Chemistry and Yousef Jameel Science & Technology Research Center, Sci Bldg # 310, The American University in Cairo, 113 Kasr El-Aini Street, Cairo 11511, Egypt. hazzazy@aucegypt.edu
Mansour
Mai M H
MM
D004300:Doping in Sports / Q000517:prevention & control*; D004921:Erythropoietin / Q000032:analysis; D024861:Genetic Enhancement; D019382:Human Growth Hormone / Q000235:genetics; D006801:Humans; D011994:Recombinant Proteins / Q000032:analysis; D013177:Sports; D015813:Substance Abuse Detection / Q000379:methods*
D011994:Recombinant Proteins; D004921:Erythropoietin; D019382:Human Growth Hormone