Altered frontal brain oxygenation in detoxified alcohol dependent patients with unaffected verbal fluency performance.
Despite prominent prefrontal deficits and alterations in anatomy, neurophysiology, and neuropsychology after long-term alcohol consumption in alcohol dependent patients, only a few investigations of functional brain activity have been published. Using functional near-infrared spectroscopy (fNIRS), we examined the concentration changes in oxygenated (O(2)Hb) and deoxygenated (HHb) haemoglobin in 17 right-handed alcohol dependent patients after detoxification and 17 matched healthy controls during a verbal fluency task. Alcohol dependent patients were characterized by normal behavioural performance (number of words produced) and physiological activation patterns (increase of O(2)Hb and decrease of HHb) over frontotemporal regions during phonological and semantical verbal fluency. However, the degree of activation was diminished (lower magnitude of oxygenation) and the localization of the activation was more restricted to inferior frontal areas as compared with the healthy participants. fNIRS is a sensitive and valid method, to detect alterations in brain functioning in clinical groups like alcohol dependent patients. Altered prefrontal functional brain activation during verbal fluency in alcohol dependent patients in a detoxified state may precede behavioural or cognitive alterations with a later onset.
Schecklmann
Martin
M
University of Wuerzburg, Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry and Psychotherapy, 97080 Wuerzburg, Germany. schecklman_m@klinik.uni-wuerzburg.de
Ehlis
Ann-Christine
AC
Plichta
Michael M
MM
Boutter
Heike K
HK
Metzger
Florian G
FG
Fallgatter
Andreas J
AJ
D000328:Adult; D000437:Alcoholism / Q000503:physiopathology / Q000534:rehabilitation*; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D010108:Oxyhemoglobins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000503:physiopathology; D019265:Spectroscopy, Near-Infrared; D013702:Temporal Lobe / Q000503:physiopathology; D014705:Verbal Behavior / Q000502:physiology*
D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin