[Cranberry (Vaccinium macrocarpon) and urinary tract infections: study model and review of literature].
Cranberries (Vaccinium macrocarpon) have long been the focus of interest for their beneficial effects in preventing urinary tract infections. Among cranberry compounds, a group of proanthocyanidins (PACs) with A-type linkages were isolated which exhibit bacterial anti-adhesion activity against uropathogenic Escherichia coli strains. These PAC inhibit P-fimbriae synthesis and induce a bacterial deformation. This activity was demonstrated on both antibiotic susceptible and resistant bacteria. This review focused on the last discoveries in the knowledge of cranberry effects.
Lavigne
J-P
JP
Institut national de la santé et de la recherche médicale, ESPRI 26, université de Montpellier-I, UFR de médecine, avenue Kennedy, CS83021, 30908 Nîmes cedex 02, France. jean-philippe.lavigne@univ-montp1.fr
Bourg
G
G
Botto
H
H
Sotto
A
A
D000900:Anti-Bacterial Agents / Q000302:isolation & purification; D002874:Chromosome Mapping; D004032:Diet; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D044945:Proanthocyanidins / Q000032:analysis* / Q000494:pharmacology / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000517:prevention & control*; D029799:Vaccinium macrocarpon / Q000737:chemistry / Q000235:genetics
D000900:Anti-Bacterial Agents; D044945:Proanthocyanidins