Fast and controlled release of triamcinolone acetonide from extrusion-spheronization pellets based on mixtures of native starch with dextrin or waxy maize starch.
Pellets composed chiefly of inexpensive starches allow modulation of the rate of release of the poorly soluble drug triamcinolone acetonide in media of pH 1.2-6.8. Wheat- or maize-starch-based pellets with 20% of white dextrin release the drug in vitro almost completely within 20 min, while maize-starch-based pellets with 5-35% of waxy maize starch sustain gradual release over periods of 9-12 hr or longer when prepared using appropriate amounts of granulation fluid.
Sergio
Almeida-Prieto
AP
Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
Isabel
de Sá Ferreira da Rocha Cristiana
de SF
José
Blanco-Méndez
BM
Otero-Espinar
Francisco J
FJ
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D003912:Dextrins / Q000737:chemistry*; D004304:Dosage Forms; D005079:Excipients / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D013213:Starch / Q000737:chemistry*; D014222:Triamcinolone Acetonide / Q000737:chemistry*; D014908:Triticum / Q000737:chemistry; D014885:Waxes / Q000737:chemistry; D003313:Zea mays / Q000737:chemistry
D003692:Delayed-Action Preparations; D003912:Dextrins; D004304:Dosage Forms; D005079:Excipients; D014885:Waxes; D013213:Starch; D014222:Triamcinolone Acetonide