title: Relationship between serum concentrations of saturated fatty acids and unsaturated fatty acids and the homeostasis model insulin resistance index in Japanese patients with type 2 diabetes mellitus.
abstract: BACKGROUND
  Consumption of polyunsaturated fatty acids (PUFA) improves the lipid metabolism of diabetics, leading to prevents of arteriosclerosis. Exact relationship between saturated fatty acids (SFA) or PUFA and the insulin resistance of diabetics are unknown.
  
  
  METHODS
  We investigated the relationship between the serum concentrations of saturated and unsaturated fatty acids and the homeostasis model insulin resistance index (HOMA-R) in Japanese patients with type 2 diabetes mellitus.
  
  
  RESULTS
  The SFA, i.e., lauric acid, myristic acid, palmitic acid, and stearic acid; the monounsaturated fatty acids (MUFA), i.e., palmitoleic acid, oleic acid, and erucic acid; and the PUFA, i.e., eicosadienoic acid, dihomo-gamma-linolenic acid, docosatetraenoic acid, and docosapentaenoic acid were positively correlated with HOMA-R. However, no correlations were found between HOMA-R and SFA, i.e., arachidic acid, behenic acid, and lignoceric acid; the MUFA, i.e., eicosenoic acid and nervonic acid; and the PUFA, i.e., linoleic acid, gamma-linolenic acid, linolenic acid, 5-8-11 eicosatrienoic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid.
  
  
  CONCLUSIONS
  Some PUFA as well as SFA were positively correlated with HOMA-R. These results indicate that the intake of diet fatty acid must be well balanced in diabetic patients and it is not always true to refrain from taking SFA and increase the unsaturated fatty acids in their diets.
authors: Aichi Medical University, Medical Clinic, Aichi, Japan.
authors: Masataka
authors: M
authors: Kusunoki
authors: Kazuhiko
authors: K
authors: Tsutsumi
authors: Meiho
authors: M
authors: Nakayama
authors: Tsuyoshi
authors: T
authors: Kurokawa
authors: Takao
authors: T
authors: Nakamura
authors: Hitoshi
authors: H
authors: Ogawa
authors: Yoshitaka
authors: Y
authors: Fukuzawa
authors: Munehiko
authors: M
authors: Morishita
authors: Tatsuro
authors: T
authors: Koide
authors: Tetsuro
authors: T
authors: Miyata
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005227:Fatty Acids / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D007564:Japan; D008297:Male; D008875:Middle Aged; D008954:Models, Biological
chemical_list: D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated