Obstetric outcomes in cancer survivors.
OBJECTIVE
To assess obstetric and neonatal outcomes in women with a prior episode of cancer.


METHODS
Data were obtained from a linkage between the Scottish Cancer Registry and routinely collected data from Scottish maternity hospitals. Obstetric outcomes in a first pregnancy which ended between 1980 and 2005 were compared in 917 women with, and 5,496 women without, a previous history of cancer.


RESULTS
The mean age at delivery was 29 years (standard deviation 5.66) and 26 years (standard deviation 5.62) in the exposed and unexposed groups respectively (P<.001). Multiple logistic regression showed that cancer survivors had higher rates of postpartum hemorrhage (odds ratio [OR] 1.56, 95% confidence interval [CI] 1.09-2.23) and operative or assisted delivery (abdominal or vaginal) (OR 1.33, 95% CI 1.14- 1.54). Preterm delivery (at less than 37 weeks of gesation) was also found to be higher in this group compared with non-cancer women (OR 1.33, 95% CI 1.01-1.76).


CONCLUSIONS
While largely reassuring to women intending to become pregnant after surviving cancer, the results indicate areas of increased risk that require additional surveillance.
Clark
H
H
Department of Obstetrics and Gynaecology, University of Aberdeen, United Kingdom. h.clark@abdn.ac.uk
Kurinczuk
J J
JJ
Lee
A J
AJ
Bhattacharya
S
S
D017668:Age of Onset; D015331:Cohort Studies; D036861:Delivery, Obstetric / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008423:Maternal Age; D009369:Neoplasms; D011247:Pregnancy / Q000706:statistics & numerical data*; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D017741:Survivors; D006113:United Kingdom / Q000453:epidemiology