The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis.
In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.
Frisullo
Giovanni
G
Istituto di Neurologia, Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168 Roma, Italy.
Mirabella
Massimiliano
M
Angelucci
Francesco
F
Caggiula
Marcella
M
Morosetti
Roberta
R
Sancricca
Cristina
C
Patanella
Agata Katia
AK
Nociti
Viviana
V
Iorio
Raffaele
R
Bianco
Assunta
A
Tomassini
Valentina
V
Pozzilli
Carlo
C
Tonali
Pietro Attilio
PA
Matarese
Giuseppe
G
Batocchi
Anna Paola
AP
D000328:Adult; D001427:Bacterial Toxins / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000378:metabolism; D006460:Hemolysin Proteins / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000473:pathology; D011863:Radioimmunoassay / Q000379:methods; D054411:Receptors, Leptin / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D012737:Sex Factors
D001427:Bacterial Toxins; D016207:Cytokines; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; D020738:Leptin; D054411:Receptors, Leptin; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C038705:hlyA protein, Listeria monocytogenes