Retaining synaptic AMPARs.
Endocytosis, exocytosis, and lateral diffusion are key mechanisms for AMPA receptor trafficking. Endocytosis of AMPARs and other postsynaptic proteins has been proposed to occur at specific endocytic zones (EZs), but the mechanisms that regulate this process are not at all clear. In this issue of Neuron, Lu et al. show that correct synaptic EZ positioning requires links between the GTPase dynamin-3 and the Homer/Shank complex.
Jaskolski
Frédéric
F
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.
Martin
Stéphane
S
Henley
Jeremy M
JM
D000818:Animals; D034286:Dynamin III / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D005089:Exocytosis / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D018091:Receptors, AMPA / Q000378:metabolism*; D013569:Synapses / Q000502:physiology*; D022161:Transport Vesicles / Q000502:physiology
D018091:Receptors, AMPA; D020558:GTP Phosphohydrolases; D034286:Dynamin III