title: [An experimental organ model for magnetic resonance imaging].
abstract: The investigation of reperfusion of organs after an ischaemic phase is of great interest in transplantation medicine. This work presents an experimental organ model for the examination of isolated canine livers by means of magnetic resonance imaging in reperfusion experiments. The perfusion of the organs inside a perfusate container in the scanner's head coil was performed with approximately physiological conditions for 1.5 hours. The pumps for the perfusate circulation were installed outside the scanner's room, where oxygenation and heating of the perfusate was also performed. In the MR examinations, T1- and T2-weighted sequences could be used to display the morphology of the organs and the spatial perfusion distribution after administration of contrast media. The images revealed oedema development during reperfusion and an inhomogenous perfusion distribution. Thus, the model allows for the non-invasive investigation of morphology and perfusion distribution in isolated reperfused organs.
authors: Medizinische Physik in der Radiologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
authors: Frank
authors: F
authors: Risse
authors: Jan M
authors: JM
authors: Boese
authors: Thomas
authors: T
authors: Hess
authors: Martin
authors: M
authors: Mory
authors: Michael
authors: M
authors: Schäfer
authors: Martha-Maria
authors: MM
authors: Gebhard
authors: Lothar R
authors: LR
authors: Schad
mesh_terms: D003287:Contrast Media; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000033:anatomy & histology; D008102:Liver Circulation; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008953:Models, Anatomic; D015424:Reperfusion / Q000379:methods
chemical_list: D003287:Contrast Media