Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers.
Consumption of fish oil (FO) is associated with reduced adverse cardiovascular events. In a randomized, blinded, placebo-controlled trial, 26 subjects (17 men and 9 women; mean age [+/- SD] 31 +/- 3.7 years) received 1 g FO capsule (n = 14) or placebo (1 g of corn oil, n = 12) for 14 days. At day 0 and day 14, heart rate (HR), blood pressure, endothelium-dependent brachial artery flow-mediated vasodilation (EDV), and endothelium-independent nitroglycerin-mediated vasodilation (EIDV) were assessed with ultrasound. FO supplementation resulted in a significant increase in EDV (20.4% +/- 13.2% vs 9.9% +/- 5.4%; P = .036) and EIDV (32.6% +/- 16.8% vs 18.0% +/- 14.9%; P = .043). Resting HR decreased by a mean of 5.9 +/- 9.4 bpm (FO) compared with placebo (mean increase of 0.73 +/- 4.8 bpm [P = .05]). FO supplementation in healthy subjects is associated with improved endothelial function and decreased resting HR.
Shah
Atman Prabodh
AP
David Geffen School of Medicine at UCLA, Harbor-UCLA Medical Center, Torrance, CA 90502, USA. apshah73@yahoo.com
Ichiuji
Anne Marie
AM
Han
Janet K
JK
Traina
Mahmoud
M
El-Bialy
Adel
A
Meymandi
Sheba Kamal
SK
Wachsner
Robin Yvonne
RY
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001916:Brachial Artery / Q000187:drug effects; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects*; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage; D011446:Prospective Studies; D016037:Single-Blind Method; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects*; D014810:Vitamin E
D004338:Drug Combinations; D005395:Fish Oils; D014810:Vitamin E; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid; D005996:Nitroglycerin