Organic anion transporting polypeptide-1B1 haplotypes in Chinese patients.
OBJECTIVE
To detect 388G>A and 521T>C variant alleles in the organic anion transporting polypeptide-1B1 (OATP1B1, encoding gene SLCO1B1) gene.


METHODS
One hundred and eleven healthy volunteers were screened for OATP1B1 alleles in our study. PCR-restriction fragment length polymorphism was used to identify the 388G>A polymorphism and a 1-step tetra-primer method was developed for the determination of 521T>C mutation.


RESULTS
The frequencies of the 388G>A and 521T>C variant alleles in the Chinese population were 73.4% and 14.0%, respectively. The frequencies of the SLCO1B1*1b and *15 haplotypes were 59.9% and 14.0%, respectively.


CONCLUSIONS
The SLCO1B1*1b and SLCO1B1*15 variants are relatively common in the Chinese population. Their frequencies are similar to that in the Japanese, but significantly different from that in Caucasians and blacks.
Xu
Lin-Yong
LY
Department of Epidemic and Health Statistics, School of Public Health, Central South University, Changsha 410078, China.
He
Yi-Jing
YJ
Zhang
Wei
W
Deng
Sheng
S
Li
Qing
Q
Zhang
Wei-Xia
WX
Liu
Zhao-Qian
ZQ
Wang
Dan
D
Huang
Yuan-Fei
YF
Zhou
Hong-Hao
HH
Sun
Zhen-Qiu
ZQ
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D027381:Liver-Specific Organic Anion Transporter 1; D008297:Male; D027361:Organic Anion Transporters / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters; C503999:SLCO1B1 protein, human