title: High-sensitivity C-reactive protein in chronic low back pain with vertebral end-plate Modic signal changes.
abstract: OBJECTIVE
  To assess high-sensitivity C-reactive protein (hsCRP) level as a measure of low-grade inflammation in relation to Modic vertebral end-plate marrow signal change on magnetic resonance imaging (MRI) in patients with chronic low back pain.
  
  
  METHODS
  All patients hospitalized for chronic low back pain in our institution were prospectively enrolled in this pilot study. Serum hsCRP concentration was measured by immunoturbidimetric assay. MR images were evaluated independently by a panel of 2 spine specialists and a radiologist. Recording of clinical parameters, MRI evaluation, and hsCRP level of each patient was blinded.
  
  
  RESULTS
  Three groups of 12 consecutive patients (Modic 0, Modic I, and Modic II signal changes on MRI) were prospectively selected. Serum hsCRP level was significantly different in the 3 groups (P = 0.002) and especially high in the Modic I group (P = 0.002 compared with Modic 0 and II groups): mean +/- SD 1.33 +/- 0.77 mg/liter in the Modic 0 group, 4.64 +/- 3.09 mg/liter in the Modic I group, and 1.75 +/- 1.30 mg/liter in the Modic II group. The only difference in clinical parameters among the 3 groups (P = 0.001) was that the worst painful moment during the previous 24 hours occurred during the late night and morning for all Modic I patients (P = 0.001 compared with Modic 0 and P = 0.002 compared with Modic II).
  
  
  CONCLUSIONS
  Low-grade inflammation indicated by high serum hsCRP level in patients with chronic low back pain could point to Modic I signal changes. This result could help physicians predict the patients with Modic I signals to more precisely prescribe the correct imaging procedure and local antiinflammatory treatment in such patients.
authors: Assistance Publique-Hôpitaux de Paris, Université René Descartes, Groupe Hospitalier Cochin, Paris, France. francois.rannou@cch.aphp.fr
authors: François
authors: F
authors: Rannou
authors: Walid
authors: W
authors: Ouanes
authors: Isabelle
authors: I
authors: Boutron
authors: Bianca
authors: B
authors: Lovisi
authors: Fouad
authors: F
authors: Fayad
authors: Yann
authors: Y
authors: Macé
authors: Didier
authors: D
authors: Borderie
authors: Henri
authors: H
authors: Guerini
authors: Serge
authors: S
authors: Poiraudeau
authors: Michel
authors: M
authors: Revel
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D017116:Low Back Pain / Q000097:blood* / Q000503:physiopathology; D008159:Lumbar Vertebrae / Q000166:cytology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009045:Motor Endplate / Q000503:physiopathology*; D010865:Pilot Projects; D011446:Prospective Studies
chemical_list: D002097:C-Reactive Protein