Acute dyskinesia on starting methylphenidate after risperidone withdrawal.
We report on acute and transient dyskinesia occurring within hours of taking modified-release methylphenidate (Concerta XL) in a stimulant-naïve 7-year-old boy who had recently stopped taking risperidone. We propose that the mechanism of this adverse drug reaction is likely to be an interaction between supersensitive dopamine receptors and acute exposure to an indirect dopamine agonist. Clinicians need to be aware of this potential side effect, and to use the combination of psychostimulants and neuroleptic drugs with caution.
Hollis
Chris P
CP
Department of Developmental Psychiatry, Division of Psychiatry, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom.
Thompson
Anne
A
D000208:Acute Disease; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003692:Delayed-Action Preparations; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011954:Receptors, Dopamine / Q000187:drug effects; D019233:Retreatment; D018967:Risperidone / Q000008:administration & dosage* / Q000627:therapeutic use
D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D003692:Delayed-Action Preparations; D018491:Dopamine Agonists; D011954:Receptors, Dopamine; D008774:Methylphenidate; D018967:Risperidone