Genetics of migraine headache in children.
A family history of migraine is very frequently noted when evaluating a child for recurrent headaches. This implies an inherited or genetic basis as a component to the underlying pathophysiology. A variety of techniques have begun to elucidate this contribution, including historical observation, population-based studies including family and twin studies, gene polymorphism association studies, and specific gene identification for isolated migraine subtypes. This line of investigation should progress in the future to a better understanding of migraine and clarification of the diagnostic subtypes for a genotype-phenotype association.
Hershey
Andrew D
AD
Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. andrew.hershey@cchmc.org
D002648:Child; D005190:Family; D006801:Humans; D008881:Migraine Disorders / Q000453:epidemiology / Q000235:genetics*; D008967:Molecular Biology; D011153:Population; D018433:Twin Studies as Topic