Sirolimus-related pulmonary toxicity mimicking 'asthma like' symptoms.
Sirolimus is an immunosuppressant with expanding use in pediatric organ transplantation, dermatology and rheumatology. We report two cases of children who developed asthma like symptoms and were diagnosed with interstitial lung disease, which responded to discontinuation of sirolimus. Pediatricians should be aware about the pulmonary side effects of sirolimus.
Gupte
G-L
GL
Liver Unit, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, United Kingdom. girish.gupte@bch.nhs.uk
Mahadevan
S
S
Clarke
J-R
JR
Alton
H
H
Beath
S-V
SV
D001249:Asthma / Q000175:diagnosis; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006627:Hirschsprung Disease / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007223:Infant; D016031:Liver Transplantation; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D020123:Sirolimus / Q000009:adverse effects* / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D020123:Sirolimus