title: Effects of early postnatal hypernutrition on nephron number and long-term renal function and structure in rats.
abstract: Various antenatal events impair nephrogenesis in humans as well as in several animal models. The consecutive low nephron endowment may contribute to an increased risk for cardiovascular and renal diseases in adulthood. However, little knowledge is available on the influence of the postnatal environment, especially nutrition, on nephrogenesis. Moreover, the consequences of early postnatal nutrition in late adulthood are not clear. We used a model of early postnatal overfeeding (OF) induced by reduction of litter size (3 pups/litter) in rats. Systolic blood pressure (SBP; plethysmography), glomerular filtration rate (clearance of creatinine), glomerular number and volume, and glomerulosclerosis were evaluated in 22-mo-old aging offspring. Early postnatal OF was associated with increased weight gain during the suckling period (+40%, P < 0.01) and a 20% increase in glomerular number (P < 0.05). However, an increase in SBP at 12 mo by an average of 18 mmHg and an increase in proteinuria (2.6-fold) and glomerulosclerosis at 22 mo of age were observed in OF male offspring compared with controls. In conclusion, early postnatal OF in the rat enhances postnatal nephrogenesis, but elevated blood pressure and glomerulosclerosis are still observed in male adults. Factors other than glomerular number reduction are likely to contribute to the arterial hypertension induced by early postnatal OF.
authors: Division of Neonatology, Hôpital la Conception, Assistance Publique-Hôpitaux de Marseille, 147, Boulevard Baille, 13385 Marseille, France.
authors: Farid
authors: F
authors: Boubred
authors: Christophe
authors: C
authors: Buffat
authors: Jean-Marc
authors: JM
authors: Feuerstein
authors: Laurent
authors: L
authors: Daniel
authors: Michel
authors: M
authors: Tsimaratos
authors: Charles
authors: C
authors: Oliver
authors: Martine
authors: M
authors: Lelièvre-Pégorier
authors: Umberto
authors: U
authors: Simeoni
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001724:Birth Weight / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D004032:Diet; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology; D007668:Kidney / Q000473:pathology* / Q000503:physiopathology*; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D009399:Nephrons / Q000187:drug effects / Q000473:pathology*; D044343:Overnutrition / Q000473:pathology* / Q000503:physiopathology*; D011507:Proteinuria / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012079:Renal Circulation / Q000502:physiology*; D012727:Sex Characteristics; D015430:Weight Gain / Q000502:physiology