title: [Immunohistochemical proof of amelogenin in teeth--a contribution to the evaluation of the age in the identification of unknown corpses].
abstract: When a corpse is found that cannot be identified, one of the forensic tasks is to determine how old the person was when she or he died. To solve this frequently asked question in forensic practice, the enamel protein amelogenin was marked immunohistochemically in 249 extracted teeth. Amelogenin is already produced during prenatal development and is gradually used up throughout life into old age. Hence, the demonstrability decreases with age. The extent of the labelling can be quantified by measuring the mean optical density (MOD). While it is not possible to determine the age on the basis of the mean optical density measurements alone, logistic regression of the MOD together with dichotomisation of the teeth according to age allows statements as to whether the person was younger or older than 30 years.
authors: Institut für Gerichtliche Medizin der Universität Tübingen.
authors: Frank
authors: F
authors: Wehner
authors: Kathrin
authors: K
authors: Secker
authors: Heinz-Dieter
authors: HD
authors: Wehner
authors: Kristina
authors: K
authors: Gehring
authors: Martin Manfred
authors: MM
authors: Schulz
mesh_terms: D000366:Age Determination by Teeth / Q000379:methods*; D053523:Amelogenin / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D012680:Sensitivity and Specificity; D014070:Tooth / Q000737:chemistry*
chemical_list: D053523:Amelogenin