Assessment of CASP7 predictions in the high accuracy template-based modeling category.
Models for target domains in the high accuracy template-based modeling category were assessed according to a number of criteria evaluating the quality of the main-chain prediction (GDT-HA), predicted sequence alignment (AL0), and side-chain rotameric state. A new criterion was introduced, the quality of the model for use in solving a crystal structure by molecular replacement. There is good evidence that modeling adds value to the template structures, particularly when multiple templates are available. However, when there is already a good template, few of the models are better for the purpose of molecular replacement.
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Randy J
RJ
Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom. rjr27@cam.ac.uk
Chavali
Gayatri
G
D019295:Computational Biology / Q000379:methods*; D008958:Models, Molecular; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry; D016415:Sequence Alignment
D011506:Proteins