The intestinal mucosa as a reservoir of HIV-1 infection after successful HAART.
The presence of HIV-1 RNA in distal duodenal mucosa was evaluated in 44 HIV-1-positive patients. HIV-1 RNA was detected in gut tissue in antiretroviral-naive patients with high plasma viral loads, as well as in patients on HAART with plasma viral loads below the limit of detection and in patients on HAART with virological failure. The intestinal mucosa seems to serve as a reservoir poorly influenced by levels of plasma viral load or HAART.
Belmonte
Liliana
L
Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
Olmos
Martin
M
Fanin
Ana
A
Parodi
Cecilia
C
Baré
Patricia
P
Concetti
Hugo
H
Pérez
Héctor
H
de Bracco
Maria Marta E
MM
Cahn
Pedro
P
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D007413:Intestinal Mucosa / Q000821:virology*; D008297:Male; D012367:RNA, Viral / Q000097:blood*; D016896:Treatment Outcome; D019562:Viral Load
D012367:RNA, Viral