Why is there so much CD45 on T cells?
The balance between kinases and phosphatases is crucial for regulating lymphocyte signaling. In this issue, McNeill et al. (2007) show that the transmembrane phosphatase CD45 has a role as both positive and negative regulator of T cell signaling.
Zamoyska
Rose
R
Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA UK. rzamoys@nimr.mrc.ac.uk
D000818:Animals; D006801:Humans; D017493:Leukocyte Common Antigens / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D017493:Leukocyte Common Antigens