title: Microscopic colitis with granuloma which responded to steroid therapy.
abstract: We present a patient with chronic watery diarrhea and weight loss, in whom colonoscopic findings were consistent with microscopic colitis, but histopathological examination revealed granulomatous inflammation. A 67-year-old Japanese female with a several year history of chronic watery diarrhea and body weight loss was admitted to our hospital. Her laboratory data showed hypoalbuminemia and high levels of serum immunoglobulin G and C-reactive protein. Colonoscopic findings were grossly normal. Histopathology showed inflammatory cell infiltrates with non-necrotizing granulomas and multinucleated giant cells, indicating that this was not conventional microscopic colitis, lymphocytic colitis or collagenous colitis. After treatment with prednisolone her symptoms and laboratory data improved dramatically, and she went into remission without the necessity of further steroid treatment.
authors: Department of Internal Medicine, School of Medicine, Keio University, Tokyo.
authors: Hiroki
authors: H
authors: Iwai
authors: Tadakazu
authors: T
authors: Hisamatsu
authors: Hideko
authors: H
authors: Iizuka
authors: Tokunari
authors: T
authors: Oyama
authors: Hajime
authors: H
authors: Higuchi
authors: Hiroyuki
authors: H
authors: Imaeda
authors: Haruhiko
authors: H
authors: Ogata
authors: Hiroshi
authors: H
authors: Nagata
authors: Syuji
authors: S
authors: Mikami
authors: Makio
authors: M
authors: Mukai
authors: Toshifumi
authors: T
authors: Hibi
mesh_terms: D000368:Aged; D046728:Colitis, Microscopic / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D003967:Diarrhea / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D013256:Steroids / Q000627:therapeutic use*
chemical_list: D013256:Steroids