The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia.
The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.
La Nasa
Giorgio
G
Cattedra di Ematologia, Centro Trapianti Midollo osseo, Ospedale R. Binaghi, Dipartimento di Scienze Mediche Internistiche, University of Cagliari, Cagliari, Italy.
Littera
Roberto
R
Locatelli
Franco
F
Lai
Sara
S
Alba
Francesco
F
Caocci
Giovanni
G
Lisini
Daniela
D
Nesci
Sonia
S
Vacca
Adriana
A
Piras
Eugenia
E
Bernardo
Maria Ester
ME
Di Cesare-Merlone
Alessandra
A
Orrù
Sandro
S
Carcassi
Carlo
C
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D017353:Gene Deletion; D005805:Genes, MHC Class I; D005820:Genetic Testing; D006086:Graft vs Host Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D018570:Risk Assessment / Q000379:methods; D013789:Thalassemia / Q000276:immunology / Q000601:surgery*; D016896:Treatment Outcome