Coenzyme biosynthesis: enzyme mechanism, structure and inhibition.
This review highlights five key reactions in vitamin biosynthesis and in particular focuses on their mechanisms and inhibition and insights from structural studies. Each of the enzymes has the potential to be a target for novel antimicrobial agents.
Scott
Duncan E
DE
University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.
Ciulli
Alessio
A
Abell
Chris
C
D000890:Anti-Infective Agents; D003067:Coenzymes / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D004798:Enzymes / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D014815:Vitamins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism
D000890:Anti-Infective Agents; D003067:Coenzymes; D004798:Enzymes; D014815:Vitamins