Graphs in molecular biology.
Graph theoretical concepts are useful for the description and analysis of interactions and relationships in biological systems. We give a brief introduction into some of the concepts and their areas of application in molecular biology. We discuss software that is available through the Bioconductor project and present a simple example application to the integration of a protein-protein interaction and a co-expression network.
Huber
Wolfgang
W
European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge CB10 1SD, UK. huber@ebi.ac.uk
Carey
Vincent J
VJ
Long
Li
L
Falcon
Seth
S
Gentleman
Robert
R
D000465:Algorithms; D019295:Computational Biology / Q000379:methods* / Q000639:trends*; D003196:Computer Graphics; D003198:Computer Simulation; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation / Q000502:physiology; D008954:Models, Biological; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology
D020543:Proteome