Site-selective modification of peptides using rhodium and palladium catalysis: complementary electrophilic and nucleophilic arylation.
The site-selective modification of peptides containing dehydroalanine, tyrosine and tryptophan residues has been achieved using rhodium catalysed conjugate additions or palladium catalysed aryl-amination and -etherification reactions.
Chapman
Christopher J
CJ
Department of Chemistry, University of Bath, Claverton Down, Bath, UKBA2 7AY.
Matsuno
Ai
A
Frost
Christopher G
CG
Willis
Michael C
MC
D000215:Acylation; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
D010455:Peptides; D010165:Palladium; D012238:Rhodium