title: Hereditary thrombophilic risk factors and venous thromboembolism in Istanbul, Turkey: the role in different clinical manifestations of venous thromboembolism.
abstract: The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (VTE) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G1691A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients (P = .003 and P = .02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT (P = .04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency.
authors: Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Capa-Istanbul, Turkey. gulferokumus@yahoo.com
authors: Gulfer
authors: G
authors: Okumus
authors: Esen
authors: E
authors: Kiyan
authors: Orhan
authors: O
authors: Arseven
authors: Levent
authors: L
authors: Tabak
authors: Reyhan
authors: R
authors: Diz-Kucukkaya
authors: Yesim
authors: Y
authors: Unlucerci
authors: Neslihan
authors: N
authors: Abaci
authors: Nihan Erginel
authors: NE
authors: Unaltuna
authors: Halim
authors: H
authors: Issever
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005165:Factor V / Q000235:genetics; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011486:Protein C / Q000378:metabolism; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D019851:Thrombophilia / Q000209:etiology* / Q000235:genetics; D054556:Venous Thromboembolism / Q000209:etiology*
chemical_list: D011486:Protein C; C095381:factor V Leiden; D006710:Homocysteine; D005165:Factor V; D011516:Prothrombin