Improved synthesis of functionalized 2,2'-bipyrroles.
A series of 2,2'-bipyrroles has been efficiently synthesized using an improved synthetic approach based on Pd(0)-catalyzed homocoupling of various 2-iodopyrroles. This new synthetic approach takes place at room temperature and in the presence of water. Functional groups such as formyl, ester, and nitrile are able to survive these reaction conditions. Solvents are found to play an important role in this reaction.
Jiao
Lijuan
L
Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, USA.
Hao
Erhong
E
Vicente
M Graça H
MG
Smith
Kevin M
KM
D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
D011758:Pyrroles; D010165:Palladium