title: Chronic infections and histamine, CRP and IL-6 levels after percutaneous transluminal coronary angioplasty.
abstract: OBJECTIVE
  Our hypothesis was that percutaneous transluminal coronary angioplasty (PTCA) reactivates certain pathogens that contribute to inflammatory processes after the intervention.
  
  
  METHODS
  We determined the levels of antibodies to human Hsp60 and levels of histamine, CRP and IL-6 in sera from 28 patients of unstable angina prior to and on days 4 and 14 after PTCA. We compared the presence of Chlamydophila pneumoniae (Cpn) and human cytomegalovirus (HCMV) DNA in peripheral blood, and levels of antibodies to Cpn, HCMV, herpes simplex virus, Epstein-Barr virus and mycobacterial Hsp65 in the serum.
  
  
  RESULTS
  Higher prevalence of Cpn and HCMV DNA was demonstrated after PTCA than before, but titers of antibodies to the pathogens did not increase. Levels of histamine, CRP and IL-6 were enhanced after PTCA. There was no association between the levels of histamine, CRP and IL-6 and the rate of pathogen DNA, or antibody titers to the pathogens, except an association between Cpn IgA and histamine levels before PTCA.
  
  
  CONCLUSIONS
  Reactivation of Cpn and HCMV and inflammatory change characterized by increased levels of histamine, CRP and IL-6 following PTCA are suggested. An association might exist between Cpn IgA antibody and histamine levels in patients of unstable angina.
authors: Division of Bacteriology, National Center for Epidemiology, Budapest, Hungary.
authors: F
authors: F
authors: Petrovay
authors: K
authors: K
authors: Heltai
authors: Z
authors: Z
authors: Kis
authors: B
authors: B
authors: Treso
authors: E
authors: E
authors: Gonczol
authors: K
authors: K
authors: Burian
authors: V
authors: V
authors: Endresz
authors: I
authors: I
authors: Valyi-Nagy
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000907:Antibodies, Bacterial / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D018834:Chaperonin 60 / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification; D002908:Chronic Disease; D003587:Cytomegalovirus / Q000302:isolation & purification; D004269:DNA, Bacterial / Q000097:blood; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006632:Histamine / Q000097:blood*; D006801:Humans; D007239:Infections / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D000907:Antibodies, Bacterial; D018834:Chaperonin 60; D004269:DNA, Bacterial; D004279:DNA, Viral; D015850:Interleukin-6; D006632:Histamine; D002097:C-Reactive Protein