title: Association of IGF-1 and IGFBP-3 with lower urinary tract symptoms in the third national health and nutrition examination survey.
abstract: BACKGROUND
  Benign growth of the prostate is thought to contribute to lower urinary tract symptoms (LUTS) in older men. It is, however, unclear which factors induce prostate growth in these men. We examined the association of insulin-like growth factor (IGF)-1 and its major binding protein IGFBP-3 with LUTS in a representative US study.
  
  
  METHODS
  We included men 60 years and older who participated in the morning session of the Third National Health and Examination Survey (NHANES III) between 1988 and 1994. Men were classified as cases (n = 91) if they reported at least three of four LUTS (nocturia, incomplete emptying, hesitancy, or weak stream) but had not had non-cancer prostate surgery in the past. Controls were men without symptoms and surgery (n = 220). All results were weighted to account for sampling probability in NHANES III. IGF-1 and IGFBP-3 were measured by ELISA and IRMA, respectively.
  
  
  RESULTS
  After mutual adjustment, men in the highest tertile of serum IGF-1 concentration had a non-significantly higher odds of LUTS than men in the lowest tertile (odds ratio (OR) = 3.20; 95% confidence interval (CI) 0.89-11.4; p-trend = 0.09]. A high concentration of IGFBP-3 was inversely related to the odds of LUTS (OR = 0.25; 95% CI 0.08-0.81; p-trend = 0.02).
  
  
  CONCLUSIONS
  A high IGFBP-3 level might affect LUTS by decreasing the bioavailability of IGF-1 or independent of IGF-1 by up-regulating apoptosis, and, thus, limiting its growth promoting effects on the prostate.
authors: Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
authors: Sabine
authors: S
authors: Rohrmann
authors: Edward
authors: E
authors: Giovannucci
authors: Ellen
authors: E
authors: Smit
authors: Elizabeth A
authors: EA
authors: Platz
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D007335:Insulin-Like Growth Factor II; D007407:Interviews as Topic; D008297:Male; D009749:Nutrition Surveys; D011506:Proteins / Q000378:metabolism; D014481:United States / Q000453:epidemiology; D014555:Urination Disorders / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology
chemical_list: C035170:IGF2 protein, human; C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins; D011506:Proteins; D007335:Insulin-Like Growth Factor II