Candida albicans drug resistance another way to cope with stress.
There are relatively few classes of antifungal drugs. This restricts clinicians' therapeutic choices and these choices are further reduced by the emergence of drug resistance. Exposure to antifungal drugs represents an environmental stress for the fungal pathogen Candida albicans. The immediate response of C. albicans to antifungals may be drug tolerance, which can lead to drug resistance. This article examines C. albicans drug resistance from the perspective of it being a stress response and investigates how commonality with other stress-response pathways gives insights into the prospects for overcoming, or preventing, drug resistance.
Cannon
Richard D
RD
Department of Oral Sciences, University of Otago, Dunedin 9054, New Zealand.
Lamping
Erwin
E
Department of Oral Sciences, University of Otago, Dunedin 9054, New Zealand.
Holmes
Ann R
AR
Department of Oral Sciences, University of Otago, Dunedin 9054, New Zealand.
Niimi
Kyoko
K
Department of Oral Sciences, University of Otago, Dunedin 9054, New Zealand.
Tanabe
Koichi
K
Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo, Japan.
Niimi
Masakazu
M
Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo, Japan.
Monk
Brian C
BC
Department of Oral Sciences, University of Otago, Dunedin 9054, New Zealand.
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000502:physiology*; D002177:Candidiasis / Q000382:microbiology; D025141:Drug Resistance, Fungal; D006801:Humans
D000935:Antifungal Agents