title: Amyotrophic lateral sclerosis in South-East England: a population-based study. The South-East England register for amyotrophic lateral sclerosis (SEALS Registry).
abstract: OBJECTIVE
  We aimed to estimate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in the South East of England. The reported incidence of ALS varies between 0.44 and 3.2 per 100,000 person years. This can partly be explained by differences in design and diagnostic criteria used. There is little population data concerning England, particularly the South East.
  
  
  METHODS
  A population study of South-East England (total population: 2,890,482) was carried out and multiple sources including our tertiary centre and district general hospitals were used for complete case ascertainment.
  
  
  RESULTS
  Between 1 January 2002 and 30 June 2006 we identified 138 people (76 males; 62 females) with a new diagnosis of ALS, giving a crude incidence of 1.06 per 100,000 person years. The projected age- and gender-adjusted annual incidence rate for England and Wales was 1.10 (95% CI 0.80-1.40). 142 people were alive on 30 June 2006, giving a point prevalence of 4.91 per 100,000 population.
  
  
  CONCLUSIONS
  Our incidence and prevalence rates are similar to those reported in comparable studies from other countries. This argues against the role of a specific exogenous factor in the aetiology of ALS in South-East England.
authors: MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK.
authors: K
authors: K
authors: Abhinav
authors: B
authors: B
authors: Stanton
authors: C
authors: C
authors: Johnston
authors: J
authors: J
authors: Hardstaff
authors: R W
authors: RW
authors: Orrell
authors: R
authors: R
authors: Howard
authors: J
authors: J
authors: Clarke
authors: M
authors: M
authors: Sakel
authors: M-A
authors: MA
authors: Ampong
authors: C E
authors: CE
authors: Shaw
authors: P N
authors: PN
authors: Leigh
authors: A
authors: A
authors: Al-Chalabi
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology*; D002391:Catchment Area, Health; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012042:Registries; D017678:Sex Distribution; D014852:Wales / Q000453:epidemiology