title: The risk of progression of scoliosis in cerebral palsy patients after intrathecal baclofen therapy.
abstract: METHODS
  Retrospective radiographic and medical chart review with matched control group.
  
  
  OBJECTIVE
  To identify the effect of intrathecal baclofen on the incidence of scoliosis, rate of curve progression, and pelvic obliquity compared with a matched cohort.
  
  
  BACKGROUND
  Although intrathecal baclofen therapy (ITB) has been shown to be effective in decreasing spasticity, case reports have described some children receiving ITB in whom progressive scoliosis was noted; other authors have described no effect on the spinal column. A controlled study has not been performed.
  
  
  METHODS
  All patients with spastic CP treated with ITB between 1997 and 2003 at a single institution were reviewed. A total of 107 patients undergoing ITB for a minimum of 2 years were identified, of which 26 patients subsequently developed or had progression of scoliosis. Twenty-five age, gender, and gross motor function classification system (GMFCS) score-matched quadriplegic CP patients with scoliosis who did not receive ITB constituted the control group used to compare the rate of curve progression and pelvic obliquity.
  
  
  RESULTS
  The average curve progression for the baclofen group after pump implantation was 16.3 degrees per year; and for the control group was 16.1 degrees per year. Both groups' curves progressed over time during growth (P = 0.001), but baclofen did not have an independent effect on curve progression (P = 0.181). Average pelvic obliquity for the 2 groups increased over time (P = 0.001), but there was no difference between the groups (P = 0.536). Twelve of 57 patients (21%) developed scoliosis after pump implantation during a mean of 3.6 years of follow-up. Thirty of 92 matched control patients (32%) not treated with ITB within the same time interval had scoliosis by maturity.
  
  
  CONCLUSIONS
  This study demonstrates that ITB has no significant effect on curve progression, pelvic obliquity, or the incidence of scoliosis when compared with an age, gender, and GMFCS score-matched control group of patients with spastic CP without ITB.
authors: Department of Orthopaedics, Alfred I. duPont Hospital for Children, Nemours Children's Clinic, Wilmington, DE 19899, USA.
authors: Hakan
authors: H
authors: Senaran
authors: Suken A
authors: SA
authors: Shah
authors: Ana
authors: A
authors: Presedo
authors: Kirk W
authors: KW
authors: Dabney
authors: Joseph W
authors: JW
authors: Glutting
authors: Freeman
authors: F
authors: Miller
mesh_terms: D000293:Adolescent; D001418:Baclofen / Q000008:administration & dosage* / Q000009:adverse effects*; D002547:Cerebral Palsy / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D012600:Scoliosis / Q000139:chemically induced / Q000453:epidemiology* / Q000209:etiology; D013997:Time Factors
chemical_list: D001418:Baclofen