[Successful desensitization using cisplatin after carboplatin-associated hypersensitivity reactions in 3 cases with recurrent ovarian carcinoma].
The standard chemotherapy for ovarian carcinoma is paclitaxel and carboplatin concomitant therapy. This combination is so frequently administered that a carboplatin-associated hypersensitivity reaction may occur after long-term treatment. Recently, we experienced carboplatin-associated hypersensitivity reactions in three cases. They showed symptoms of tachycardia, chest tightness, and dyspnea. We report these cases that could be readministered platinum agent using the cisplatin desensitization method. This method was relatively safe and successful for patients with platinum-sensitive disease.
Hosaka
Masayoshi
M
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine.
Ebina
Yasuhiko
Y
Moriwaki
Masashi
M
Hara
Yoko
Y
Araki
Naoto
N
Todo
Yukiharu
Y
Takeda
Mahito
M
Watari
Hidemichi
H
Sakuragi
Noriaki
N
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D016190:Carboplatin / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage*; D003888:Desensitization, Immunologic / Q000379:methods*; D004342:Drug Hypersensitivity / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D016190:Carboplatin; D002945:Cisplatin