title: HLA class I and class II haplotypes in admixed families from several regions of Mexico.
abstract: We studied HLA class I and class II alleles in 191 Mexican families (381 non-related individuals) to directly obtain the HLA-A/B/DRB1/DQB1 haplotypes and their linkage disequilibrium (LD). The most frequent HLA haplotypes observed were: A*02-B*39-DRB1*04-DQB1*0302, A*02-B*35-DRB1*04-DQB1*0302, A*68-B*39-DRB1*04-DQB1*0302, A*02-B*35-DRB1*08-DQB1*04, A*33-B*1402-DRB1*01-DQB1*05, and A*24-B*35-DRB1*04-DQB1*0302. The four most common haplotypes found by our study involve those previously reported in Amerindian populations. LD analysis of HLA-A-B and HLA-B-DRB1 loci showed significant associations between A29(19)-B44(12), A33(19)-B65(14), A1-B8, A26(19)-B44(12), A24(9)-B61(40), B65(14)-DR1, B8-DR17(3), B44(12)-DR7, B7-DR15(2), and B39(16)-DR4. Also, all DRB1-DQB1 associations showed significant LD values. Admixture estimations using a trihybrid model showed that Mexicans from the State of Sinaloa (Northern Mexico) have a greater proportion of European genetic component compared with Mexicans from the Central area of Mexico, who have a greater percentage of Amerindian genes. Our results are important for future comparative genetic studies of different Mexican ethnic groups with special relevance to disease association and transplantation studies.
authors: Molecular Genetics Laboratory, ENAH, Mexico City, Mexico.
authors: Rodrigo
authors: R
authors: Barquera
authors: Joaquín
authors: J
authors: Zúñiga
authors: Raquel
authors: R
authors: Hernández-Díaz
authors: Victor
authors: V
authors: Acuña-Alonzo
authors: Karla
authors: K
authors: Montoya-Gama
authors: Juan
authors: J
authors: Moscoso
authors: Diana
authors: D
authors: Torres-García
authors: Claudia
authors: C
authors: García-Salas
authors: Beatriz
authors: B
authors: Silva
authors: David
authors: D
authors: Cruz-Robles
authors: Antonio
authors: A
authors: Arnaiz-Villena
authors: Gilberto
authors: G
authors: Vargas-Alarcón
authors: Julio
authors: J
authors: Granados
mesh_terms: D005260:Female; D005828:Genetics, Population; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008800:Mexico
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II