title: Histopathologic study of corneal stromal dystrophies: a 10-year experience.
abstract: OBJECTIVE
  To determine the frequency and describe the histopathologic features of stromal corneal dystrophies over a 10-year period.
  
  
  METHODS
  A single-centered, retrospective analysis was performed on corneal specimens diagnosed as stromal dystrophies retrieved from the Henry C. Witelson Ophthalmic Pathology Laboratory and Registry (Montreal, Canada) over a period of 10 years. Corneal specimens obtained during keratoplasty were subjected to hematoxylin and eosin, periodic acid-Schiff, and other special staining.
  
  
  RESULTS
  During the period of the study, 885 corneal specimens from penetrating keratoplasties were received. Twenty-six (2.9%) specimens from a total of 22 patients showed stromal corneal dystrophies: 17 (65.4%) eyes with lattice dystrophy, 5 (19.2%) eyes with combined granular/lattice ("Avellino") dystrophy, 3 (11.5%) eyes with granular dystrophy, and 1 (3.9%) eye with macular dystrophy.
  
  
  CONCLUSIONS
  Corneal stromal dystrophies have distinct histopathologic features, which can be diagnosed with routine and special staining, particularly for combined granular/lattice (Avellino) dystrophy. Clinically, combined granular/lattice (Avellino) dystrophy can have features of both lattice and granular dystrophies, which can be misleading for diagnosis. Lattice dystrophy was the most frequent stromal dystrophy in this particular population.
authors: Department of Ophthalmology and Pathology, The McGill University Health Center & Henry C. Witelson Ocular Pathology Laboratory, Montreal, Canada. leonnsantos@gmail.com
authors: Leonardo N
authors: LN
authors: Santos
authors: Bruno F
authors: BF
authors: Fernandes
authors: Leticia Rielo
authors: LR
authors: de Moura
authors: Devinder P
authors: DP
authors: Cheema
authors: Shawn
authors: S
authors: Maloney
authors: Patrick
authors: P
authors: Logan
authors: Miguel N
authors: MN
authors: Burnier
mesh_terms: D000328:Adult; D003317:Corneal Dystrophies, Hereditary / Q000473:pathology* / Q000601:surgery; D003319:Corneal Stroma / Q000473:pathology*; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies