title: Yersinia as oral live carrier vaccine: influence of Yersinia outer proteins (Yops) on the T-cell response.
abstract: Attenuated enteropathogenic Yersinia strains are attractive candidates for the development of oral live carrier vaccines. Yersiniae colonize the small intestine and invade lymphoid tissue of the terminal ileum where they replicate extracellularly. Yersiniae can be engineered to secrete or translocate heterologous antigens into the cytosol of antigen-presenting cells by their type 3 secretion system (T3SS). This results in the induction of both cellular and humoral immune responses to heterologous antigens of viral, bacterial and parasitic origin. In this review, we summarize the progress in developing Yersinia-based vaccine carrier strains by mutating the T3SS effector proteins of Yersinia called Yops (Yersinia outer proteins) to both attenuate the strains and to modulate the T-cell response.
authors: Max von Pettenkofer-Institut, LMU München, Pettenkoferstr. 9a, D-80336 München, Germany. truelzsch@mvp.med.uni-muenchen.de
authors: Konrad
authors: K
authors: Trülzsch
authors: Thorsten
authors: T
authors: Sporleder
authors: Robert
authors: R
authors: Leibiger
authors: Holger
authors: H
authors: Rüssmann
authors: Jürgen
authors: J
authors: Heesemann
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007114:Immunization / Q000379:methods*; D013601:T-Lymphocytes / Q000276:immunology*; D014612:Vaccines / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D015007:Yersinia / Q000276:immunology*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D015395:Histocompatibility Antigens Class I; D014612:Vaccines; D014613:Vaccines, Attenuated; C063239:yopE protein, Yersinia