[Concept of inducing of rapid immunological protection against pathogens].
Concept of construction of new type of vaccines for inducing rapid nonspecific immunological protection against pathogens by activation of innate immunity mechanisms has been formulated. Materials about formula of the concept, theses of theory of innate immunity, and experimental and clinical data, which confirm the concept, are presented. Results of studies with recombinant proinflammatorycytokines and synthetic ligands for Toll-like receptors as well as with polycomponent vaccine containing antigens of opportunistic bacteria (Immunovac VP-4) are also presented. Obtained data allowed to assume that activation of innate immunity mechanisms by preparations carrying pathogen-associated and molecular structures of microorganisms can result in formation of rapid and nonspecific protection against any pathogen.
Semenov
B F
BF
Zverev
V V
VV
D000281:Administration, Intranasal; D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003140:Communicable Disease Control / Q000379:methods* / Q000639:trends; D003429:Cross Reactions; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000517:prevention & control; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007115:Immunization Schedule; D008024:Ligands; D011994:Recombinant Proteins / Q000096:biosynthesis; D012141:Respiratory Tract Infections / Q000517:prevention & control*; D013203:Staphylococcal Infections / Q000097:blood; D051193:Toll-Like Receptors / Q000378:metabolism; D016896:Treatment Outcome; D014611:Vaccination; D017778:Vaccines, Combined / Q000008:administration & dosage* / Q000276:immunology
D001428:Bacterial Vaccines; D016207:Cytokines; D008024:Ligands; D011994:Recombinant Proteins; D051193:Toll-Like Receptors; C088865:VP-4 vaccine; D017778:Vaccines, Combined