title: The paraventricular nucleus of hypothalamus mediates the pressor response to noradrenergic stimulation of the medial prefrontal cortex in unanesthetized rats.
abstract: The medial prefrontal cortex (MPFC) is a structure that is also involved in cardiovascular modulation. The injection of norepinephrine (NE) into the prelimbic (PL) area of the MPFC of unanesthetized rats evokes a pressor response which is mediated by acute vasopressin release. Vasopressin is synthesized by magnocellular cells of the paraventricular (PVN) and supraoptic nucleus (SON) of the hypothalamus. In the present study, we endeavored to determine which vasopressin-synthesizing hypothalamic nucleus is involved in the pressor pathway activated after NE injection into the PL area of the MPFC. We report here that lidocaine microinjection into the SON did not change the pressor response evoked by NE injection into the PL. However, the response to NE was blocked by prior injection of lidocaine or CoCl(2) into the PVN, indicating that this area is responsible for the mediation of this pressor response. A neuroanatomic experiment in which the neuronal tracer biotinylated dextran amine (BDA) was microinjected into the MPFC showed a lack of axons or neuronal cell bodies in the PVN, indicating that there are no direct connections between the PL area of the MPFC and the PVN. The results suggest that the PVN is involved in the mediation of the pressor response to NE in the PL area and that this pathway must relay in other brain structures before reaching the PVN.
authors: School of Dentistry, North Parana University, UNOPAR, Brazil.
authors: Karen Barros Parron
authors: KB
authors: Fernandes
authors: Rodrigo Fiacadori
authors: RF
authors: Tavares
authors: Gislaine Garcia
authors: GG
authors: Pelosi
authors: Fernando Morgan Aguiar
authors: FM
authors: Corrêa
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D003035:Cobalt / Q000494:pharmacology; D004347:Drug Interactions; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013566:Sympathomimetics / Q000494:pharmacology*; D014667:Vasopressins / Q000378:metabolism; D014851:Wakefulness
chemical_list: D000779:Anesthetics, Local; D016587:Antimutagenic Agents; D013566:Sympathomimetics; D014667:Vasopressins; D003035:Cobalt; D008012:Lidocaine; C018021:cobaltous chloride; D009638:Norepinephrine