title: Early average change in tumor size in a phase 2 trial: efficient endpoint or false promise?
authors: Larry V
authors: LV
authors: Rubinstein
authors: Janet E
authors: JE
authors: Dancey
authors: Edward L
authors: EL
authors: Korn
authors: Malcolm A
authors: MA
authors: Smith
authors: John J
authors: JJ
authors: Wright
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017322:Clinical Trials, Phase II as Topic / Q000379:methods*; D018450:Disease Progression; D018572:Disease-Free Survival; D023381:Endpoint Determination / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design; D018401:Sample Size; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents