title: Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines.
abstract: The structure-activity relationships of new quinoline based compounds were investigated. Quinoline-5,8-dione and styrylquinoline scaffolds were used for the design of potentially active compounds. The novel analogues had comparable antiproliferative activity to cisplatin when evaluated in a bioassay against the P388 leukemia cell line. However, these compounds appeared far less efficient against SK-N-MC neuroepithelioma cells. Analogues without the 5,8-dione structure but containing the 8-carboxylic acid group were also found to induce antiproliferative activity. Hydrophobicity as measured by HPLC did not correlate with antiproliferative activity.
authors: Department of Organic Chemistry, Institute of Chemistry, University of Silesia, PL-40006 Katowice, Poland.
authors: B
authors: B
authors: Podeszwa
authors: H
authors: H
authors: Niedbala
authors: J
authors: J
authors: Polanski
authors: R
authors: R
authors: Musiol
authors: D
authors: D
authors: Tabak
authors: J
authors: J
authors: Finster
authors: K
authors: K
authors: Serafin
authors: M
authors: M
authors: Milczarek
authors: J
authors: J
authors: Wietrzyk
authors: S
authors: S
authors: Boryczka
authors: W
authors: W
authors: Mol
authors: J
authors: J
authors: Jampilek
authors: J
authors: J
authors: Dohnal
authors: D S
authors: DS
authors: Kalinowski
authors: D R
authors: DR
authors: Richardson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002264:Carboxylic Acids; D011804:Quinolines; C481600:styrylquinoline