Circulating hepatocyte growth factor level but not basic fibroblast growth factor level is elevated in angiography-proven symptomatic peripheral artery disease.
Circulating vasogenic factors may be up-regulated in response to ischemia to promote angiogenesis in patients with peripheral artery disease (PAD). Studies on this are limited in number and size, and results are inconsistent, especially regarding basic fibroblast growth factor (bFGF) level. From March 1999 to April 2004, all consecutive patients with lower limb PAD having serum samples at the time of intervention were recruited. The diameter of the primary PAD lesion had to be at least 70% stenotic at the lower limb artery. Control subjects, who underwent angiography, were free of PAD, coronary disease, and other major medical diseases. Serum samples were analyzed for circulating hepatocyte growth factor (HGF) and bFGF levels. Patients with PAD (n = 60) had higher circulating HGF levels (mean +/- SEM, 1,544 +/- 238 vs 970 +/- 129 pg/mL; P = .04) but similar bFGF distribution tertiles (P = .55) compared with control subjects (n = 30). Thirty-six patients with summed PAD lesion lengths exceeding 5 cm demonstrated a significantly higher circulating HGF level compared with control subjects (mean +/- SEM, 1,701 +/- 335 vs 970 +/- 129 pg/mL; P = .048). Patients with concurrent coronary artery disease tend to have a higher circulating HGF level (mean +/- SEM, 1,606 +/- 365 vs 970 +/- 129 pg/mL; P = .06) but not a higher bFGF level compared with control subjects. Circulating HGF level, but not bFGF level, is significantly elevated in patients with symptomatic angiographically documented PAD, especially in those with more extensive involvement.
Lin
Jiunn-Wen
JW
Cardiovascular Center, Taichung Veterans General Hospital, Taichung 407, Taiwan.
Sheu
Wayne Huey-Herng
WH
Lee
Wen-Jane
WJ
Chen
Ying-Tsung
YT
Liu
Tsun-Jui
TJ
Ting
Chih-Tai
CT
Lee
Wen-Lieng
WL
D000368:Aged; D000792:Angiography; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005263:Femoral Artery; D016222:Fibroblast Growth Factor 2 / Q000097:blood; D005500:Follow-Up Studies; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D007083:Iliac Artery; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
D015415:Biomarkers; D016222:Fibroblast Growth Factor 2; D017228:Hepatocyte Growth Factor