Glucocorticoid and sex hormone receptors: clinical implications and therapeutic relevance.
In general, steroid hormones exert their effects through intracellular receptors, the glucocorticoid (GR), mineralocorticoid (MR), androgen (AR), estrogen (ER), and progesterone (PR) receptors. In this brief review, we will focus on glucocorticoid and sex hormone actions in the skin through their distinct receptors and discuss their clinical relevance.
Stefanaki
Christina
C
Department of Dermatology, Andreas Sygros Hospital for Skin Diseases, University of Athens, 5 Ionos Dragoumi Street, Kaisariani, Athens 16121, Greece.
Chrousos
George P
GP
Katsambas
Andreas
A
D000818:Animals; D003879:Dermatologic Agents / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008297:Male; D011944:Receptors, Androgen / Q000187:drug effects / Q000502:physiology*; D011960:Receptors, Estrogen / Q000187:drug effects / Q000502:physiology*; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D012871:Skin Diseases / Q000188:drug therapy / Q000503:physiopathology*; D012879:Skin Physiological Phenomena
D003879:Dermatologic Agents; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid