Isoechinulin-type alkaloids, variecolorins A-L, from halotolerant Aspergillus variecolor.
Twelve new compounds, variecolorins A-L ( 1- 12), together with eleven known analogues ( 13- 23) were isolated from the broth of a halotolerant fungus, Aspergillus variecolor. The structures of compounds 1- 12 were determined by chemical and spectroscopic methods. Compounds 1- 11, 13- 15, and 20- 23 exhibited weak radical scavenging activity against DPPH, with IC 50 values from 43 to 103 microM. The new compounds 1- 12 all were essentially nontoxic against the P388, HL-60, BEL-7402, and A-549 cell lines with IC 50 values from 70 to 260 microM.
Wang
Wen-Liang
WL
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
Lu
Zhen-Yu
ZY
Tao
Hong-Wen
HW
Zhu
Tian-Jiao
TJ
Fang
Yu-Chun
YC
Gu
Qian-Qun
QQ
Zhu
Wei-Ming
WM
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D001713:Biphenyl Compounds; D002681:China; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology; D054712:Salinity
D000470:Alkaloids; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl