title: A case of manic episode during treatment with 5-fluorouracil, epirubicin and cyclophosphamide for breast cancer.
abstract: A 41-year-old woman with breast cancer developed a manic episode while being treated with a 5-fluorouracil-epirubicin-cyclophosphamide combination (most likely caused by the first drug). Chemotherapy was discontinued, and antipsychotic treatment with haloperidol and olanzapine was instituted. She recovered after 10 days. Normal computerized tomography (CT) scans and neurological examinations were consistent with the absence of neurological symptoms on physical exam.
authors: Unit of Psychiatry, Department of Neurosciences, Sant'Andrea Hospital, 2nd Medical School, Sapienza University, 00189 Rome, Italy. isabella.pacchiarotti@uniroma1.it
authors: Isabella
authors: I
authors: Pacchiarotti
authors: Lorenzo
authors: L
authors: Mazzarini
authors: Patrizia
authors: P
authors: Pellegrini
authors: Viola
authors: V
authors: Venturelli
authors: Gabriele
authors: G
authors: Sani
authors: José
authors: J
authors: Sánchez-Moreno
authors: Iginia
authors: I
authors: Mancinelli
authors: Roberto
authors: R
authors: Tatarelli
authors: Giorgio D
authors: GD
authors: Kotzalidis
authors: Paolo
authors: P
authors: Girardi
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000139:chemically induced*; D001943:Breast Neoplasms / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D015251:Epirubicin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D007558:Italy
chemical_list: D000903:Antibiotics, Antineoplastic; D018906:Antineoplastic Agents, Alkylating; D007166:Immunosuppressive Agents; D015251:Epirubicin; D003520:Cyclophosphamide; D005472:Fluorouracil