Fatty liver due to high levels of serum tacrolimus after liver transplantation.
Tacrolimus has been used extensively for immunosuppressive therapy in pediatric liver transplant recipients. However, patients who are exposed to high levels of serum tacrolimus tend to be associated with a higher incidence of significant nephrotoxicity, neurotoxicity, pruritus, alopecia, diabetes and infection. We herein report a child who developed increased serum transaminase levels and liver steatosis as a result of raised trough blood level of tacrolimus (30 ng/ml for 3 days) in association with rotavirus gastroenteritis.
Tümgör
Gökhan
G
Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University, Faculty of Medicine, Izmir, Turkey.
Ankan
Ciğdem
C
Nart
Deniz
D
Kihiç
Murat
M
Aydoğdu
Sema
S
D001706:Biopsy; D002675:Child, Preschool; D005234:Fatty Liver / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000097:blood; D016031:Liver Transplantation; D016559:Tacrolimus / Q000009:adverse effects* / Q000097:blood
D007166:Immunosuppressive Agents; D016559:Tacrolimus