Clinicopathological improvement of non-alcoholic steatohepatitis associated with weight loss during a 14-year follow-up period.
A 44-year-old woman was admitted to our hospital for investigation of persistently abnormal liver function tests. She was mildly obese and hypertensive, but not alcoholic. Laboratory studies showed high levels of aminotransferases, total cholesterol, triglycerides, hyaluronic acid and an abnormally low adiponectin level. Viral markers were negative and autoimmune liver disease was excluded. Laparoscopic and histopathological examinations were compatible with non-alcoholic steatohepatitis (NASH), grade 1, stage 2. The patient developed diabetes 2 years after the first examination, and weight management was provided. She was admitted again to our hospital 14 years later. Her body weight had since decreased by 12 kg and laboratory studies disclosed high triglycerides, normalization of aminotransferases and adiponectin in parallel with body weight loss. Laparoscopic and histopathological examinations were compatible with NASH, grade 1, stage 0, indicating improvement relative to the first admission. We report on a case of NASH with reduction of body weight within a period of 14 years, associated with clinicopathological improvement.
Nishide
Tomohiro
T
Department of Hepatology, Toranomon Hospital, Tokyo, Japan.
Ikeda
Kenji
K
Kawamura
Yusuke
Y
Hosaka
Tetsuya
T
Kobayashi
Masahiro
M
Suzuki
Yoshiyuki
Y
Kumada
Hiromitsu
H
D000328:Adult; D001706:Biopsy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004038:Diet, Reducing; D005234:Fatty Liver / Q000150:complications* / Q000178:diet therapy* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications; D009765:Obesity / Q000150:complications* / Q000178:diet therapy*; D015431:Weight Loss