A network of growth and transcription factors controls neuronal differentation and survival in the developing ear.
Inner ear neurons develop from the otic placode and connect hair cells with central neurons in auditory brain stem nuclei. Otic neurogenesis is a developmental process which can be separated into different cellular states that are characterized by a distinct combination of molecular markers. Neurogenesis is highly regulated by a network of extrinsic and intrinsic factors, whose participation in auditory neurogenesis is discussed. Trophic factors include the fibroblast growth factor, neurotrophins and insulin-like peptide families. The expression domains of transcription factor families and their roles in the regulation of intracellular signaling pathways associated with neurogenesis are also discussed. Understanding and defining the key factors and gene networks in the development and function of the inner ear represents an important step towards defeating deafness.
Sanchez-Calderon
Hortensia
H
Instituto de Investigaciones Biomedicas "Alberto Sols", CSIC-UAM, Madrid, Spain.
Milo
Marta
M
Leon
Yolanda
Y
Varela-Nieto
Isabel
I
D000818:Animals; D002454:Cell Differentiation; D002470:Cell Survival; D007758:Ear, Inner / Q000196:embryology* / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D009414:Nerve Growth Factors; D014157:Transcription Factors; D005346:Fibroblast Growth Factors; D007334:Insulin-Like Growth Factor I