title: Cytogenetic biclonality in a child with hypocellular primary myelodysplastic syndrome.
abstract: A 13-year-old boy with hypocellular primary myelodysplastic syndrome, classified as refractory cytopenia, underwent umbilical cord blood transplantation. Cytogenetic analysis revealed two rare biclonal chromosomal aberrations, del(17)(p12) and del(11)(q23). Cytogenetic analysis was a valuable tool in diagnosis, in clinical decision-making, and in treatment and follow-up. To our knowledge, this is the first reported case of cytogenetic biclonality involving chromosomes 17 and 11.
authors: Cytogenetic Laboratory, Bone Marrow Transplant Center, National Cancer Institute (INCA), Praça Cruz Vermelha, CEP 20230-130, Rio de Janeiro, RJ, Brazil.
authors: Eliane Ferreira
authors: EF
authors: Rodrigues
authors: Daiane Corrêa
authors: DC
authors: de Souza
authors: Adriana
authors: A
authors: Camargo
authors: Rita de Cássia
authors: Rde C
authors: Tavares
authors: Luiz Fernando
authors: LF
authors: Bouzas
authors: Maria Helena
authors: MH
authors: Ornellas
authors: Teresa de Souza
authors: Tde S
authors: Fernandez
mesh_terms: D000293:Adolescent; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D020732:Cytogenetic Analysis; D003582:Cytogenetics; D005312:Fetal Blood / Q000378:metabolism; D017353:Gene Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D033581:Stem Cell Transplantation; D014180:Transplantation