A new allele uncovers the role of echinus in the control of ommatidial rotation in the Drosophila eye.
The precise orientation of the ommatidia in the Drosophila eye is achieved through a specialized process of cell migration taking place in the third-instar eye imaginal disc when ommatidial clusters rotate by 90 degrees. This process is strictly coordinated with the establishment of planar cell polarity (PCP), but it relies on a specific set of genes that control its mechanism independently from PCP signaling. Recently, the epidermal growth factor receptor (EGFR) pathway has been implicated in determining ommatidial rotation. We have isolated a new allele of echinus, a gene known to control the patterning and number of interommatidial cells. We show that echinus displays defects in the rotation of ommatidia that are not evident until mid-pupal stages, and we propose that echinus action is that of opposing EGFR by an unknown mechanism and that this can explain both its influence in ommatidial rotation and lattice programmed cell death (PCD).
Montrasio
Silvia
S
Dulbecco Telethon Institute, DIBIT, San Raffaele Scientific Institute, Milan, Italy.
Mlodzik
Marek
M
Fanto
Manolis
M
D000483:Alleles; D000818:Animals; D002465:Cell Movement; D054910:Compound Eye, Arthropod / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000235:genetics* / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D017344:Genes, Insect; D005838:Genotype; D011679:Pupa / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D015398:Signal Transduction
D029721:Drosophila Proteins; C523696:ec protein, Drosophila; D066246:ErbB Receptors; D003546:Cysteine Endopeptidases