title: Organic anion transporting polypeptide-1B1 haplotypes in Chinese patients.
abstract: OBJECTIVE
  To detect 388G>A and 521T>C variant alleles in the organic anion transporting polypeptide-1B1 (OATP1B1, encoding gene SLCO1B1) gene.
  
  
  METHODS
  One hundred and eleven healthy volunteers were screened for OATP1B1 alleles in our study. PCR-restriction fragment length polymorphism was used to identify the 388G>A polymorphism and a 1-step tetra-primer method was developed for the determination of 521T>C mutation.
  
  
  RESULTS
  The frequencies of the 388G>A and 521T>C variant alleles in the Chinese population were 73.4% and 14.0%, respectively. The frequencies of the SLCO1B1*1b and *15 haplotypes were 59.9% and 14.0%, respectively.
  
  
  CONCLUSIONS
  The SLCO1B1*1b and SLCO1B1*15 variants are relatively common in the Chinese population. Their frequencies are similar to that in the Japanese, but significantly different from that in Caucasians and blacks.
authors: Department of Epidemic and Health Statistics, School of Public Health, Central South University, Changsha 410078, China.
authors: Lin-Yong
authors: LY
authors: Xu
authors: Yi-Jing
authors: YJ
authors: He
authors: Wei
authors: W
authors: Zhang
authors: Sheng
authors: S
authors: Deng
authors: Qing
authors: Q
authors: Li
authors: Wei-Xia
authors: WX
authors: Zhang
authors: Zhao-Qian
authors: ZQ
authors: Liu
authors: Dan
authors: D
authors: Wang
authors: Yuan-Fei
authors: YF
authors: Huang
authors: Hong-Hao
authors: HH
authors: Zhou
authors: Zhen-Qiu
authors: ZQ
authors: Sun
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D027381:Liver-Specific Organic Anion Transporter 1; D008297:Male; D027361:Organic Anion Transporters / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters; C503999:SLCO1B1 protein, human