title: Prediction of atrial fibrillation with atrial late potentials and pathological chemoreflexsensitivity.
abstract: BACKGROUND
  Atrial fibrillation (AF) is a very common arrhythmia that often causes the serious complication of a stroke.
  
  
  OBJECTIVE
  The aim was to evaluate the utility of pathological chemoreflexsensitivity (PCHRS) and atrial late potentials (ALP) to predict AF in follow-up.
  
  
  METHODS
  We investigated a prospective study on the basis of our observation about a PCHRS and ALP in paroxysmal AF. The PCHRS was predefined as a chemoreflexsensitivity below 3.0 ms/mmHg and ALP were predefined as a filtered P-wave duration > or =120 ms and a root mean square voltage of the last 20 ms of the P-wave < or =3.5 microV. A P-wave triggered P-wave signal averaged electrocardiograph (ECG) and chemoreflexsensitivity was performed on 250 consecutive patients who were divided into four groups. Group I consisted of patients with ALP and PCHRS, patients of group II had only ALP, a PCHRS was only present in group III, and patients of group IV had neither ALP nor PCHRS.
  
  
  RESULTS
  During the mean follow-up of 37.8 months AF was observed in 10 patients (4%). The patients of the four groups were similar according to clinical baseline characteristics. The incidence of AF was higher in group I (18% of patients) than in group II (6% of patients, P = 0.229) and significantly higher than in group III (3% of patients, P = 0.034) or group IV (1% of patients, P < 0.0001). Patients with ALP and PCHRS showed a 33-fold risk (P < 0.001) for the onset AF.
  
  
  CONCLUSIONS
  The results of our study suggest that the probability of AF could be predicted with a P-wave signal averaged ECG and an analysis of chemoreflexsensitivity. The predictive power of the combination of ALP and PCHRS seemed not high enough for risk stratification.
authors: Department of Cardiology, West-German Heart Centre, University of Duisburg-Essen, Germany. marco.budeus@uk-essen.de
authors: Marco
authors: M
authors: Budeus
authors: Marcus
authors: M
authors: Hennersdorf
authors: Nico
authors: N
authors: Reinsch
authors: Heinrich
authors: H
authors: Wieneke
authors: Stefan
authors: S
authors: Sack
authors: Raimund
authors: R
authors: Erbel
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000503:physiopathology; D002628:Chemoreceptor Cells / Q000503:physiopathology; D004452:Echocardiography; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies
chemical_list: D010100:Oxygen