Six new ergosterols from the marine-derived fungus Rhizopus sp.
Six new ergosterols, including 3beta-hydroxyl-(22E, 24R)-ergosta-5,8,22-trien-7,15-dione (1), 3beta-hydroxyl-(22E, 24R)-ergosta-5,8,14,22-tetraen-7-one (2), 3beta,15beta-dihydroxyl-(22E, 24R)-ergosta-5,8(14),22-trien-7-one (3), 3beta,15alpha-dihydroxyl-(22E, 24R)-ergosta-5,8(14),22-trien-7-one (4), 3beta-hydroxyl-(22E, 24R)-ergosta-5,8(14),22-trien-7,15-dione (5), and 5alpha,8alpha-epidioxy-23,24(R)-dimethylcholesta-6,9(11),22-trien-3beta-ol (6), have been isolated from the marine-derived fungus Rhizopus sp., along with four known ones (7-10). The structures of the new compounds were determined on the basis of extensive spectroscopic data. All compounds were evaluated for their cytotoxic activities on P388, A549, HL-60, and BEL-7420 cell lines by the MTT and SRB methods.
Wang
Fazuo
F
Key Laboratory of Marine Drugs, Ocean University of China, Qingdao 266003, People's Republic of China.
Fang
Yuchun
Y
Zhang
Min
M
Lin
Aiqun
A
Zhu
Tianjiao
T
Gu
Qianqun
Q
Zhu
Weiming
W
D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004875:Ergosterol / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012233:Rhizopus / Q000737:chemistry*; D012623:Seawater / Q000382:microbiology
D004875:Ergosterol