title: Study on effect and mechanism of sodium ferulate in preventing and treating ozone induced lung injury in mice.
abstract: OBJECTIVE
  To study the effect and mechanism of sodium ferulate (SF) in preventing and treating ozone (O3) induced lung oxidative injury in mice.
  
  
  METHODS
  Lung oxidative injury model mice were established by making them inhale O3. The activity of anti-oxidase and membranous microviscosity in epithelial cells in the lung of mice were determined, and the ultrastructural change of lung tissues was observed with electromicroscopy.
  
  
  RESULTS
  Activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were reduced, while membranous lipo-microviscosity significantly increased in the pulmonary epithelial cells of model mice, revealing ultrastructural change. These abnormal changes were reversed by SF treatment, which was manifested as the significantly raised activities of SOD and GSH-Px after treatment with high and moderate doses of SF, showing a significant difference compared with those in the model group (P<0.01). Membranous lipo-microviscosity basically approached that in the control group (P>0.05); electron microscopic examination showed a basically normal morphological structure of pulmonary epithelial cells, with the change in lung injury significantly milder than that in the model group.
  
  
  CONCLUSIONS
  O3 could induce oxidative injury of lungs in mice, and SF could enhance the anti-oxidation capacity of mice and scavenge the oxygen free radicals so as to alleviate the injury.
authors: Medical College of Yangzhou University, Jiangsu, 225001, China. jgz7718@sina.com
authors: De-jun
authors: DJ
authors: Wang
authors: Wei-dong
authors: WD
authors: Zhou
authors: Xiao-jun
authors: XJ
authors: Dai
authors: Yan
authors: Y
authors: Yan
mesh_terms: D000818:Animals; D003373:Coumaric Acids / Q000494:pharmacology / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000648:ultrastructure; D008171:Lung Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology / Q000517:prevention & control*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D010126:Ozone / Q000009:adverse effects*; D013482:Superoxide Dismutase / Q000378:metabolism; D014783:Viscosity / Q000187:drug effects
chemical_list: D003373:Coumaric Acids; D008563:Membrane Lipids; D010126:Ozone; C004999:ferulic acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase