Neuroprotective effect of methanolic extracts of Allium cepa on ischemia and reperfusion-induced cerebral injury.
The present study is designed to investigate the effect of methanolic extract of outer scales and edible portions of Allium cepa bulb on ischemia and reperfusion-induced cerebral injury. Global cerebral ischemia was induced by bilateral carotid artery occlusion for 10 min followed by reperfusion for 24 h. Pretreatment with methanolic extract of outer scales (100 mg/kg and 200 mg/kg) and edible portions (100 mg/kg and 200 mg/kg) of A. cepa bulb markedly reduced cerebral infarct size and attenuated impairment in short-term memory and motor coordination. The protective effect of methanolic extract of outer scales and edible portions of A. cepa bulb was accompanied by a marked decrease in mitochondrial TBARS.
Shri
Richa
R
Department of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala 147002, Punjab, India. rshri587@hotmail.com
Singh Bora
Kundan
K
D000818:Animals; D001921:Brain / Q000378:metabolism; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000473:pathology; D016166:Free Radical Scavengers / Q000032:analysis; D008570:Memory, Short-Term / Q000187:drug effects; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000032:analysis* / Q000494:pharmacology / Q000627:therapeutic use; D019697:Onions / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances