[Pyrophosphate and mineralization (TNSALP, PC-1, ANK)].
Pyrophosphate inhibits mineralization, and tissue non-specific alkaline phosphatase (TNSALP) increases phosphate concentration by cleaving pyrophosphate, which is important for the regulation of mineralization in bone. Moreover, PC-1 (plasma cell membrane glycoprotein-1) on matrix vesicle and osteoblast plasma membrane, as well as ANK (ankylosis) on osteoblast plasma membrane induce extracellular pyrophosphate. The pyrophosphate production by PC-1 and ANK and TNSALP, as well as some mineralization-inhibiting factors, (for example osteopontin) induced by these molecules, is considered to maintain the normal process of mineralization. The abnormality of these molecules causes various mineralization disorders.
Kaji
Hiroshi
H
Kobe University Graduate School of Medicine, Department of Internal Medicine, Division of Diabetes, Metabolism and Endocrinology.
D000469:Alkaline Phosphatase / Q000502:physiology; D000818:Animals; D000844:Ankylosis / Q000378:metabolism; D002113:Calcification, Physiologic / Q000502:physiology*; D011756:Diphosphates / Q000378:metabolism*; D051379:Mice; D010727:Phosphoric Diester Hydrolases / Q000502:physiology; D011755:Pyrophosphatases / Q000502:physiology
D011756:Diphosphates; D000469:Alkaline Phosphatase; D010727:Phosphoric Diester Hydrolases; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1; D011755:Pyrophosphatases