Modelling and control of HIV dynamics.
Various models of HIV infection and evolution have been considered in the literature. This paper considers a variant of the Wodarz and Nowak mathematical model, adding "aggressiveness" as a new state variable in order to quantify the strength of the virus and its response to drugs. Although the model proposed is relatively simple, simulation results suggest that it may be useful in predicting the impact of the effectiveness of therapy on HIV dynamics.
Landi
Alberto
A
Department of Electrical Systems and Automation, University of Pisa, Pisa, Italy. landi@dsea.unipi.it
Mazzoldi
Alberto
A
Andreoni
Chiara
C
Bianchi
Matteo
M
Cavallini
Andrea
A
Laurino
Marco
M
Ricotti
Leonardo
L
Iuliano
Rodolfo
R
Matteoli
Barbara
B
Ceccherini-Nelli
Luca
L
D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007558:Italy; D008954:Models, Biological; D015233:Models, Statistical; D019562:Viral Load / Q000706:statistics & numerical data