title: Effects of a triclosan dentifrice on plaque formation, gingivitis and gingival bleeding in pregnant women: five-month clinical results.
abstract: The objective of this study was to determine the effects of a triclosan/copolymer dentifrice on plaque formation, gingivitis and gingival bleeding in pregnant subjects. This double-blind clinical study was carried out in 180 women at 3 months of pregnancy. The subjects were stratified into two balanced groups according to their baseline plaque, gingivitis and bleeding scores. Subjects received a thorough dental prophylaxis and were assigned to brush with either a placebo or triclosan dentifrice for five months. They were instructed to brush their teeth as they normally would, twice a day for one minute per brushing. Follow-up examinations after five months of dentifrice use evaluated supragingival plaque, gingivitis and gingival bleeding. After five months, the triclosan dentifrice significantly reduced plaque formation, gingivitis and gingival bleeding by 40.5%, 22.5% and 35.3%, respectively, compared to the placebo group (p<0.05).
authors: Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. dtcam@mahidol.ac.th
authors: P
authors: P
authors: Kraivaphan
authors: C
authors: C
authors: Amornchat
authors: T
authors: T
authors: Triratana
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control*; D003802:Dentifrices / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005891:Gingivitis / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D010919:Placebos; D011247:Pregnancy; D013785:Thailand; D014260:Triclosan / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D003802:Dentifrices; D010919:Placebos; D014260:Triclosan