title: The Canadian multicentre study of deep brain stimulation for cervical dystonia.
abstract: Deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) is an effective treatment for generalized dystonia. Its role in the management of other types of dystonia is uncertain. Therefore we performed a prospective, single-blind, multicentre study assessing the efficacy and safety of bilateral GPi-DBS in 10 patients with severe, chronic, medication-resistant cervical dystonia. Two blinded neurologists assessed patients before surgery and at 6 and 12 months post-operatively using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). The primary outcome measure was the severity subscore (range 0-30, higher scores indicating greater impairment). Secondary outcomes included disability (0 to 30), pain (0 to 40) subscores and total scores of the TWSTRS, Short Form-36 and Beck depression inventory. Swallowing and neuropsychological assessment were also performed at baseline and 12 months. One-way repeated measures analysis of variance was used to analyse the data. The TWSTRS severity score improved from a mean (SD) of 14.7 (4.2) before surgery to 8.4 (4.4) at 12 months post-operatively (P = 0.003). The disability and pain scores improved from 14.9 (3.8) and 26.6 (3.6) before surgery, to 5.4 (7.0) and 9.2 (13.1) at 12 months, respectively (both P < 0.001). General health and physical functioning as well as depression scores improved significantly. Complications were mild and reversible in four patients. Some changes in neuropsychological tests were observed, although these did not impact daily life or employment. Our results support the efficacy and safety of GPi-DBS for the treatment of patients with severe and prolonged cervical dystonia who have failed medical management.
authors: Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada. zkiss@ucalgary.ca
authors: Zelma H T
authors: ZH
authors: Kiss
authors: Kristina
authors: K
authors: Doig-Beyaert
authors: Michael
authors: M
authors: Eliasziw
authors: Joseph
authors: J
authors: Tsui
authors: Angela
authors: A
authors: Haffenden
authors: Oksana
authors: O
authors: Suchowersky
mesh_terms: D000704:Analysis of Variance; D002170:Canada; D046690:Deep Brain Stimulation / Q000379:methods*; D003863:Depression / Q000628:therapy; D005260:Female; D005917:Globus Pallidus / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010865:Pilot Projects; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D016037:Single-Blind Method; D014103:Torticollis / Q000473:pathology / Q000523:psychology / Q000628:therapy*; D016896:Treatment Outcome