[In vitro biomineralization of self-assembly oligopeptide T2].
Oligopeptide T2, a kind of PA (Peptide Amphiphile) molecule, which could build up nano-fiber by self-assembly was designed and synthesized in this study. And the double-diffusion gel system was applied on this molecule to investigate its biomineralization features in vitro. The results showed that T2 could obviously reduce the hydroxyapatite (HA) formation period. And HA was found to possess the characteristics of non-crystalline by analysis of X-ray diffraction (XRD) and scanning electronic microscopy (SEM). These findings point to the conclusion that the negatively charged zone in T2 might make this molecule have the function of promoting HA biomineralization in vitro. And the mechanism responsible for the procession of HA biomineralization needs further research.
Wang
Lei
L
Department of Prosthodotics, College of Stomatology, Peking University, Beijing 100081, China. wanglei-dentist@163.com
Bai
Wei
W
Feng
Hailan
H
Jia
Xinru
X
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D018786:Bone Substitutes / Q000737:chemistry*; D002113:Calcification, Physiologic; D017886:Durapatite / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry
D001672:Biocompatible Materials; D018786:Bone Substitutes; D009842:Oligopeptides; D017886:Durapatite