Evolution of enzymes and pathways for the biosynthesis of cofactors.
The evolution of metabolic pathways is discussed with reference to the biosynthesis of a number of vitamins and cofactors. Retrograde and patchwork models are highlighted and their relevance to our knowledge of pathway processes and enzymes is examined. Pathway complexity is explained in terms of the acquisition of broad specificity enzymes.
Holliday
Gemma L
GL
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK CB10 1SD. gemma@ebi.ac.uk
Thornton
Janet M
JM
Marquet
Andrée
A
Smith
Alison G
AG
Rébeillé
Fabrice
F
Mendel
Ralf
R
Schubert
Heidi L
HL
Lawrence
Andrew D
AD
Warren
Martin J
MJ
D005075:Biological Evolution; D003067:Coenzymes / Q000096:biosynthesis*; D004798:Enzymes / Q000378:metabolism*; D008954:Models, Biological
D003067:Coenzymes; D004798:Enzymes