title: Association between oxidative stress and coronary lipid risk factors in hypothyroid women is independent of body mass index.
abstract: Hypothyroidism enhances the progression of atherogenesis. Furthermore, dyslipidemia, hypertension, and obesity are known risk factors for atherosclerosis. Oxidative stress is implicated in the pathogenesis of cardiovascular diseases. However, there are contradicting reports on the existence of oxidative stress in hypothyroidism. Thus, the aim of the study is to evaluate the presence of oxidative stress in hypothyroidism and, if so, its possible association with various coronary lipid risk factors. The present study was carried out in a group of 27 freshly diagnosed normotensive primary hypothyroid female patients in comparison with healthy subjects. Their body mass index (BMI), serum thyroid profile, lipid profile, glucose, protein carbonylation, thiobarbituric acid reactive substances (TBARS), and blood antioxidant enzyme levels were estimated. The TBARS and protein carbonylation were significantly higher in cases compared with those in controls. Reduced glutathione was lower and glutathione peroxidase was higher in the test group compared with those in controls. Various lipid risk factors for coronary artery disease were significantly higher among the hypothyroid women in comparison with those in controls. The level of TBARS correlated significantly with various lipid risk factors among the hypothyroid women even after correcting the effect of BMI. However, no significant associations were observed between BMI and these risk factors when the effect of TBARS was nullified. In hypothyroidism, the coronary lipid risk factors seem to be more associated with lipid peroxidation than BMI. In conclusion, the present study indicates the presence of oxidative stress in hypothyroid patients and its association with atherogenic dyslipidemia, which is independent of BMI.
authors: Department of Biochemistry, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry-605 006, India.
authors: Nivedita
authors: N
authors: Nanda
authors: Zachariah
authors: Z
authors: Bobby
authors: Abdoul
authors: A
authors: Hamide
authors: Bidhan Chandra
authors: BC
authors: Koner
authors: Magadi Gopalakrishna
authors: MG
authors: Sridhar
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002374:Catalase / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006801:Humans; D007037:Hypothyroidism / Q000097:blood*; D007453:Iodide Peroxidase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012307:Risk Factors; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D001786:Blood Glucose; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D014284:Triiodothyronine; D002374:Catalase; D007453:Iodide Peroxidase; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D005978:Glutathione; D013974:Thyroxine