Factors predicting poor survival after resection of stage IA non-small cell lung cancer.
OBJECTIVE
Using a national cancer registry, we determined the postoperative survival of patients with stage IA non-small cell lung cancer in the United States from 1988 to 1997 and identified factors that affect survival.


METHODS
Within the Surveillance, Epidemiology, and End Result Program database, 10,761 patients were identified as having stage IA non-small cell lung cancer and underwent curative surgical resection from 1988 to 1997. Univariate analyses were performed by the log-rank test to determine predictors of survival, and multivariable analysis was performed by a Cox regression model.


RESULTS
Overall 5-year survival was 58%. On univariate analysis, tumor size, gender, age, and extent of resection were significant predictors of survival. Five-year survival of patients with tumors 2.1 to 3.0 cm was lower than that for patients with tumors 2.0 cm or smaller: 55% versus 60% (P < .0001). Men faired significantly worse than women, with a 5-year survival of 53% versus 63% (P < .0001). Patients older than the median age of 67 years had worse 5-year survival than had those under the median age: 52% versus 65% (P < .0001). Patients undergoing sublobar resections showed poorer 5-year survival than patients undergoing anatomic resections: 44% versus 61% (P < .0001). On multivariable analysis with a Cox regression model, all 4 variables remained statistically significant.


CONCLUSIONS
The survival of patients with stage IA non-small cell lung cancer within the United States is significantly worse than survival reported from single-institution studies. This study identifies 4 factors that may affect survival in resected stage IA non-small cell lung cancer: tumor size, gender, age, and extent of resection.
Chang
Michael Y
MY
Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, and Boston VA Healthcare, Harvard School of Public Health, Boston, Mass, USA. Michael.Y.Chang@kp.org
Mentzer
Steven J
SJ
Colson
Yolonda L
YL
Linden
Philip A
PA
Jaklitsch
Michael T
MT
Lipsitz
Stuart R
SR
Sugarbaker
David J
DJ
D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D018426:SEER Program; D015996:Survival Rate; D014481:United States / Q000453:epidemiology