title: The role of intracellular amyloid beta in Alzheimer's disease.
abstract: Extracellular amyloid beta (Abeta) that confers neurotoxicity and modulates synaptic plasticity and memory function has been central to the amyloid hypothesis of Alzheimer's disease (AD) pathology. Like many other misfolded proteins identified in neurodegenerative disorders, Abeta also accumulates inside the AD neurons. This intracellular Abeta affects a variety of cellular physiology from protein degradation, axonal transport, autophagy to apoptosis, further documenting the role of Abeta in AD. Therapeutics targeting intracellular Abeta could be effective treatment for AD.
authors: Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China.
authors: Meng
authors: M
authors: Li
authors: Liying
authors: L
authors: Chen
authors: Daniel Hong Seng
authors: DH
authors: Lee
authors: Long-Chuan
authors: LC
authors: Yu
authors: Yan
authors: Y
authors: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides