Emerging drugs for epilepsy and other treatment options.
Epilepsies are amongst the most frequent chronic neurological conditions. Patients suffer from spontaneously recurring seizures because of sudden extensive electrical gray matter discharges. Although the current drug therapy allows many patients at least some degree of a satisfying course of the disease, a substantial number of patients remain without adequate seizure control. Reasons are either refractoriness to anticonvulsant drugs or intolerable drug-related side effects. Epilepsy surgery should be considered in these cases as possible treatment option. Nevertheless, a considerable rate of patients will not be suitable candidates or continue to have seizures despite surgery. Therefore there is a substantial need for better antiepileptic drugs. The aim of this review is to highlight currently emerging different treatment approaches which may ameliorate the perspectives of patients with difficult-to-treat epilepsies.
Stefan
H
H
Epilepsy Center (ZEE)-Neurological Clinic, University Erlangen-Nuernberg, Schwabachanlage, Erlangen, Germany. hermann.stefan@neuro.imed.uni-erlangen.de
Steinhoff
B J
BJ
D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D004827:Epilepsy / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D006801:Humans
D000927:Anticonvulsants