Treatment options for actinic keratoses.
Actinic keratoses are rough, scaly lesions that commonly occur on sun-exposed areas of the skin. The prevalence of the condition increases with age. Actinic keratoses are thought to be carcinomas in situ, which can progress to squamous cell carcinomas. The decision to treat can be based on cosmetic reasons; symptom relief; or, most importantly, the prevention of malignancy and metastasis. Treatment options include ablative (destructive) therapies such as cryosurgery, curettage with electrosurgery, and photodynamic therapy. Topical therapies are used in patients with multiple lesions. Fluorouracil has been the traditional topical treatment for actinic keratoses, although imiquimod 5% cream and diclofenac 3% gel are effective alternative therapies. There are too few controlled trials comparing treatment modalities for physicians to make sound, evidence-based treatment decisions.
McIntyre
William J
WJ
University of Arkansas for Medical Sciences Area Health Education Center Southwest, Texarkana 71854, USA. wjmcintyre@uams.edu
Downs
Michael R
MR
Bedwell
Sondra A
SA
D000287:Administration, Topical; D000634:Aminoquinolines / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002615:Chemexfoliation; D003452:Cryosurgery; D003475:Curettage; D004008:Diclofenac / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077271:Imiquimod; D007642:Keratosis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D010778:Photochemotherapy; D015995:Prevalence; D012878:Skin Neoplasms / Q000517:prevention & control
D000634:Aminoquinolines; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D004008:Diclofenac; D000077271:Imiquimod; D005472:Fluorouracil