The molecular mechanism of embryonic stem cell pluripotency and self-renewal.
The self-renewal and pluripotency of embryonic stem cells (ESCs) is regulated by a network, which consists of a series of cell factors in microenviroments, a chain of transcription factors and certain signal conduction pathways. This article reviews recent progress in this field to elucidate the mechanism involved.
Liu
YuXiao
Y
Laboratory of Stem Cell Biology, Beijing Institution of Transfusion Medicine, Beijing 100850, China.
Ji
Lei
L
Ten
Yue
Y
Wang
YunFang
Y
Pei
XueTao
X
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000166:cytology*; D005346:Fibroblast Growth Factors / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D051379:Mice; D000071317:Nanog Homeobox Protein; D050814:Octamer Transcription Factor-3 / Q000378:metabolism; D027701:Organic Cation Transport Proteins / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism; D000099254:Organic Cation Transporter 3
D019485:Bone Morphogenetic Proteins; D004268:DNA-Binding Proteins; D005346:Fibroblast Growth Factors; D018398:Homeodomain Proteins; D000071317:Nanog Homeobox Protein; D050814:Octamer Transcription Factor-3; D027701:Organic Cation Transport Proteins; D016212:Transforming Growth Factor beta; D051153:Wnt Proteins; D000099254:Organic Cation Transporter 3; C486780:NANOG protein, human; C475540:Nanog protein, mouse; C494173:POU5F1 protein, human; C494174:Pou5f1 protein, mouse