title: The presence of dental disease can be a risk factor for recurrent Helicobacter pylori infection after eradication therapy: a 3-year follow-up.
abstract: OBJECTIVE
  We investigated whether dental disease might be associated with a higher recurrence of Helicobacter pylori infection after successful eradication by triple therapy.
  
  
  METHODS
  Consecutive patients with successful H. pylori eradication, defined by negative results for both histology and (13)C-urea breath test (UBT) performed 6 weeks after triple therapy, were enrolled in the study. Each patient was scheduled for serial UBT and dental assessments at the end of the first, second, and third years. Patients were categorized into a "dental disease" group or "no dental disease" group at the first-year follow-up. Patients in the dental disease group whose dental disease had been cured during the second- and third-year follow-up periods, were transferred to a "dental treatment" group.
  
  
  RESULTS
  The first-year H. pylori recurrence rate was higher in the 159 patients with dental disease than in those 200 patients without dental disease (13.2 % vs. 3.5 %, P < 0.001; relative risk [95 %CI], 4.2 [1.7 - 10.1]). At both the second-year and the third-year follow-up, the annual H. pylori recurrence rates were higher in the dental disease group than in the no dental disease group or dental treatment group (second year, 18.4 % vs. 2.8 % or vs. 5.7 %, P < 0.001; third year, 20 % vs. 3.8 % or vs. 6.3 %, P < 0.001).
  
  
  CONCLUSIONS
  The presence of dental disease could predispose to recurrent H. pylori infection after successful eradication. Dental surveillance and care after H. pylori eradication is a rational step for preventing recurrence of H. pylori, especially in those with dental diseases.
authors: Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan. sheubs@mail.ncku.edu.tw
authors: B-S
authors: BS
authors: Sheu
authors: H-C
authors: HC
authors: Cheng
authors: Y-J
authors: YJ
authors: Yang
authors: H-B
authors: HB
authors: Yang
authors: J-J
authors: JJ
authors: Wu
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011336:Probability; D054328:Proton Pump Inhibitors; D012008:Recurrence; D018570:Risk Assessment; D009057:Stomatognathic Diseases / Q000175:diagnosis / Q000453:epidemiology*; D013997:Time Factors
chemical_list: D054328:Proton Pump Inhibitors