[Incomplete isosexual puberty, myopathy, and pseudoprolactinoma in a 20-year-old girl with primary hypothyroidism].
Primary hypothyroidism, possibly due to Hashimoto thyroiditis in infancy, led to abnormal puberty in this girl: menstruation began at the age of 16 years, with a cycle duration of 40 days and lack of axillary and pubic hair. Hypertrophic myopathy without myotony was also present, and assays showed very low levels of follicular hormone. The severity of the primary hypothyroidism was shown by the TSH level of 236 microIU/mL, a prolactin level of 390 microU/mL and a large sella turcica. This clinical-laboratory picture is the hallmark of a hormonal receptor disorder related to primary hypothyroidism and is reversible with substitution treatment.
Sidibé
El Hassane
el H
Centre médical Marc Sankalé, BP 5062, Fann Dakar, Sénégal. sidibeeh@refer.sn
D000308:Adrenocortical Hyperfunction / Q000150:complications* / Q000188:drug therapy; D000328:Adult; D000505:Alopecia / Q000150:complications*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy; D009135:Muscular Diseases / Q000150:complications*; D011627:Puberty; D013963:Thyroid Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D013963:Thyroid Hormones; D006854:Hydrocortisone