Contribution of analytical microscopies to human neurodegenerative diseases research (PSP and AD).
Using analytical microscopies we have observed an increase of Fe(2+) iron-induced oxidative stress inside pathological ferritin (Ft). This finding, together with the presence of Ft in myelinated axons associated with oligodendrocyte processes and myelin sheet fraying, suggests that a dysfunction of ferritin (a ferritinopathy) may be the non-specific aging-dependent pathogenic event responsible for neurodegenerative disease.
Quintana
Carmen
C
Instituto Microelectronica de Madrid, Parque Tecnologici de Madrid, 8 Isaac Newton, 28760 Tres Cantos, Madrid, Spain. carmen@imm.cnm.csic.es
D000544:Alzheimer Disease / Q000473:pathology*; D000818:Animals; D006801:Humans; D008853:Microscopy / Q000379:methods*; D046529:Microscopy, Electron, Transmission; D017550:Spectroscopy, Fourier Transform Infrared; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*