title: Thyrotoxic hypokalemic periodic paralysis triggered by high carbohydrate diet.
abstract: Thyrotoxic hypokalemic periodic paralysis is an uncommon disorder characterized by elevated thyroid hormone, muscle weakness or paralysis, and intracellular shifts of potassium leading to hypokalemia. This article presents a case of thyrotoxic hypokalemic periodic paralysis in a 22-year old Hispanic man with nonfamilial thyrotoxic hypokalemic periodic paralysis triggered by a high carbohydrate diet. Laboratory studies showed elevated thyroid hormone, decreased thyroid-stimulating hormone, and hypokalemia. Rapid reduction in thyroid hormone levels by giving antithyroid drugs such as propylthiouracil and prompt potassium therapy with frequent measurements of serum potassium levels during therapy to avoid catastrophic hyperkalemia when potassium starts to shift back from intracellular to extracellular compartments can lead to successful outcome.
authors: Nephrology and Dialysis Center, Department of Medicine, Renal Division, Coney Island Hospital, Brooklyn, NY, USA. goodkidneys@aol.com
authors: Adel S
authors: AS
authors: El-Hennawy
authors: Mushammat
authors: M
authors: Nesa
authors: Aza K
authors: AK
authors: Mahmood
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D006801:Humans; D006947:Hyperkalemia / Q000517:prevention & control; D020514:Hypokalemic Periodic Paralysis / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D011188:Potassium / Q000378:metabolism*; D011189:Potassium Chloride / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D011441:Propylthiouracil / Q000627:therapeutic use; D013963:Thyroid Hormones / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D000319:Adrenergic beta-Antagonists; D013956:Antithyroid Agents; D004040:Dietary Carbohydrates; D013963:Thyroid Hormones; D011189:Potassium Chloride; D011441:Propylthiouracil; D013972:Thyrotropin; D011433:Propranolol; D011188:Potassium