Fabrication of nanofibrous inhaler device.
It has been proven that administration by inhalation is one of the alternative and effective approaches to dose biomedicines such as insulin for diabetics. Here, we introduce a new approach to fabricate the inhaler, posing the merits of not using volatile solvent, having selectable size of drug particles, and being simple and low cost compared with conventional devices. Creatine particles were prepared by spray-drying, and simultaneously a nanofiber mat of crosslinked poly(vinyl pyrrolidone) (PVP) was used to collect the graduated creatine nanoparticles. The scanning electron microscopy (SEM) photos indicated that the nanoparticles were individually dispersed without any agglomerate on the PVP nanofibers and released after the nitrogen gas flow (10 L/min) passed through the PVP nanofiber mat. This approach is unique and universal for nonagglomerate dispersing of nanoparticles and releasing without using any dispersing solvent.
Ni
Henmei
H
Biomaterials Center, National Institute for Materials Science, Tsukuba City, Ibaraki Prefecture, Japan. Ni.Henmei@nims.go.jp
Kamimura
Wataru
W
Uchida
Yoshiyuki
Y
D000280:Administration, Inhalation; D004867:Equipment Design / Q000295:instrumentation* / Q000379:methods; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009330:Nebulizers and Vaporizers