Systemic oxytocin and vasopressin excite gastrointestinal motility through oxytocin receptor in rabbits.
The aim of the present study was to investigate the effect of systemic oxytocin (OT) and vasopressin (VP) on the motility of stomach and duodenum. Two plastic balloons made of condom were inserted into stomach and duodenum to monitor the change of mean pressure. Intravenous injection of OT (0.1-0.8 microg kg(-1)) or VP (0.02-0.08 IU kg(-1)) dose-dependently increased the stomach and duodenum pressure. Pretreatment of atosiban (1 microg kg(-1)), the specific OT receptor (OTR) antagonist, attenuated the excitatory effect of OT or VP on the pressure of stomach and duodenum. Pretreatment of V1880 (1 microg kg(-1)), the specific V1 receptor blocker, did not influence this effect. So we conclude that both of OT and VP injected systemically increased the gastric and duodenum motility via OTR.
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Department of Physiology, Heze Medical College, Heze, China.
Kong
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Liu
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D005769:Gastrointestinal Motility / Q000187:drug effects* / Q000502:physiology; D006727:Hormone Antagonists / Q000494:pharmacology; D008297:Male; D008365:Manometry; D010121:Oxytocin / Q000008:administration & dosage*; D011817:Rabbits; D018045:Receptors, Oxytocin / Q000187:drug effects* / Q000378:metabolism; D017483:Receptors, Vasopressin / Q000187:drug effects / Q000378:metabolism; D014667:Vasopressins / Q000008:administration & dosage*; D014668:Vasotocin / Q000031:analogs & derivatives / Q000494:pharmacology
D006727:Hormone Antagonists; D018045:Receptors, Oxytocin; D017483:Receptors, Vasopressin; C047046:atosiban; D014667:Vasopressins; D010121:Oxytocin; D014668:Vasotocin