title: Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs.
abstract: The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.
authors: Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences (SLU), Biomedical Centre, Box 597, SE-751 24 Uppsala, Sweden.
authors: Nicolette H C
authors: NH
authors: Salmon Hillbertz
authors: Magnus
authors: M
authors: Isaksson
authors: Elinor K
authors: EK
authors: Karlsson
authors: Eva
authors: E
authors: Hellmén
authors: Gerli Rosengren
authors: GR
authors: Pielberg
authors: Peter
authors: P
authors: Savolainen
authors: Claire M
authors: CM
authors: Wade
authors: Henrik
authors: H
authors: von Euler
authors: Ulla
authors: U
authors: Gustafson
authors: Ake
authors: A
authors: Hedhammar
authors: Mats
authors: M
authors: Nilsson
authors: Kerstin
authors: K
authors: Lindblad-Toh
authors: Leif
authors: L
authors: Andersson
authors: Göran
authors: G
authors: Andersson
mesh_terms: D000818:Animals; D003884:Dermoid Cyst / Q000235:genetics / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D051518:Fibroblast Growth Factor 3 / Q000235:genetics; D051519:Fibroblast Growth Factor 4 / Q000235:genetics; D005346:Fibroblast Growth Factors / Q000235:genetics*; D020440:Gene Duplication; D020022:Genetic Predisposition to Disease; D005838:Genotype; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics; D010641:Phenotype; D012868:Skin Abnormalities / Q000235:genetics* / Q000473:pathology; D016136:Spina Bifida Occulta / Q000235:genetics / Q000662:veterinary*
chemical_list: D051518:Fibroblast Growth Factor 3; D051519:Fibroblast Growth Factor 4; D009363:Neoplasm Proteins; D005346:Fibroblast Growth Factors