On-line grasp control is mediated by the contralateral hemisphere.
Electrophysiological recordings from monkeys, as well as functional imaging and neuropsychological work with humans, have suggested that a region in the anterior portion of the intraparietal sulcus (aIPS) is involved in prehensile movements. With recent methodological advances using transcranial magnetic stimulation (TMS), we can now causally attribute anatomy with function to more precisely determine the specific involvement of aIPS in grasping. It has recently been demonstrated that aIPS is specifically involved in executing a grasp under conditions of both constant target requirements, as well as in correcting a movement under conditions in which a target perturbation occurs. In the present study, we extend these findings by determining the differential contribution of the left and right hemisphere to executing a grasping movement with the left and right hands. Transient disruption of left aIPS at movement onset impairs grasping with the right but not the left hand, and disruption of right aIPS impairs grasping with the left but not the right hand. We conclude that grasping is a lateralized process, relying exclusively on the contralateral hemisphere, and discuss the implications of these findings in relationship to models of hemispheric dominance for motor control.
Rice
Nichola J
NJ
HB 6162 Moore Hall, Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, New Hampshire 03755, USA.
Tunik
Eugene
E
Cross
Emily S
ES
Grafton
Scott T
ST
D000328:Adult; D001696:Biomechanical Phenomena; D001931:Brain Mapping; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology*; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000033:anatomy & histology / Q000502:physiology; D009068:Movement / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D010296:Parietal Lobe / Q000033:anatomy & histology* / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation