Asymmetric membrane capsule for osmotic delivery of flurbiprofen.
An asymmetric membrane capsule of cellulose acetate for osmotic delivery of flurbiprofen has been developed and influence of osmogents and solubilizing agent on in vitro drug release were evaluated. The capsule membrane was prepared by the phase inversion technique. To ensure the osmotic delivery of drug, two approaches were adopted: (i) the drug was encapsulated with osmogents like sodium chloride and mannitol to increase the osmotic pressure of the core, and (ii) the drug was encapsulated with sodium lauryl sulfate in the core of the formulation to increase the solubility and thus its osmotic pressure. Scanning electron microscopy of the membrane confirmed its porous, dense asymmetric nature. Dye test revealed in situ pore formation. The in vitro release study showed that as the proportion of osmogent and solubilizing agent was increased the release rate also increased. A good correlation was observed between the zero-order rate constant and the amount of the osmogent and solubilizing agent used.
Choudhury
Pratim K
PK
Department of Pharmacy, Fiji School of Medicine, Suva, Fiji Islands.
Ranawat
Mahendra S
MS
Pillai
Mousumi K
MK
Chauhan
Chetan S
CS
D000548:Amaranth Dye / Q000737:chemistry; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D002214:Capsules / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods*; D005480:Flurbiprofen / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008353:Mannitol / Q000737:chemistry; D008855:Microscopy, Electron, Scanning / Q000379:methods; D009994:Osmolar Concentration; D009995:Osmosis; D009997:Osmotic Pressure; D016062:Porosity; D012965:Sodium Chloride / Q000737:chemistry; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D012967:Sodium Dodecyl Sulfate; C005062:acetylcellulose; D008353:Mannitol; D012965:Sodium Chloride; D005480:Flurbiprofen; D002482:Cellulose; D000548:Amaranth Dye