title: Molecular biology of peptide pheromone production and reception in mice.
abstract: Intraspecies communication via pheromones plays an important role in social and sexual behaviors, which are critical for survival and reproduction in many animal species. In mice, pheromonal signals are processed by the parallel action of two olfactory systems: the main olfactory system and the vomeronasal pathway. Pheromones are recognized by chemosensory receptors expressed in the main olfactory epithelium and by V1R- and V2R-type receptors expressed in the vomeronasal organ (VNO). Mice take advantage of the chemical properties of both types of pheromones (i.e., volatile/nonvolatile) to precisely control the spatial and temporal transmission of their individual signals. The recent discovery of the exocrine gland-secreting peptide (ESP) family, which appears to encode a VNO-specific ligand repertoire, should open a new avenue to understanding peptide pheromone-mediated communication via the vomeronasal pathway in mice. In this chapter, I will review the current knowledge on genetic and molecular aspects of peptide pheromones and their receptors, by focusing primarily on the mouse VNO system. It is also an intriguing aspect to discuss peptide pheromones in the context of the evolutionary importance of species-specific chemical communication.
authors: Department of Integrated Biosciences, The University of Tokyo, Chiba 277-8562, Japan.
authors: Kazushige
authors: K
authors: Touhara
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D019143:Evolution, Molecular; D005088:Exocrine Glands; D016678:Genome; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009812:Odorants; D010455:Peptides / Q000737:chemistry; D010675:Pheromones / Q000378:metabolism*; D012727:Sex Characteristics; D015398:Signal Transduction; D013045:Species Specificity; D019147:Vomeronasal Organ / Q000378:metabolism
chemical_list: D010455:Peptides; D010675:Pheromones