title: Synthesis and biochemical evaluation of O-acetyl-ADP-ribose and N-acetyl analogs.
abstract: Synthetic routes for the preparation of O-acetyl-ADP-ribose and two novel non-hydrolyzable analogs containing an N-acetyl are described and shown to interact with the macro domain of histone protein H2A1.1.
authors: Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors: Lindsay R
authors: LR
authors: Comstock
authors: John M
authors: JM
authors: Denu
mesh_terms: D000107:Acetylation; D000246:Adenosine Diphosphate Ribose / Q000096:biosynthesis*; D008958:Models, Molecular; D038961:O-Acetyl-ADP-Ribose / Q000096:biosynthesis* / Q000737:chemistry; D037761:Sirtuins / Q000378:metabolism
chemical_list: D038961:O-Acetyl-ADP-Ribose; D000246:Adenosine Diphosphate Ribose; D037761:Sirtuins