title: [The impact of large vessel proximity on effectiveness of radiofrequency ablation of hepatocellular carcinoma: a controlled study].
abstract: OBJECTIVE
  To evaluate the risk of radiofrequency ablation treatment failure for hepatocellular carcinomas (HCC) next to large vessels.
  
  
  METHODS
  Between May 2000 and October 2002, from a total of 83 patients treated by radiofrequency ablation for HCC in a single center, 13 patients with tumor<or=3.5 cm contacting a vessel >or=3 mm in diameter (Group A) were matched with 13 patients with similar size tumors located away from large vessels (Group B). Immediate response and recurrence rate were evaluated on CT.
  
  
  RESULTS
  After mean follow-up interval of 39+/-16.5 months for Group A and 39+/-14 months for Group B, local recurrence rates were 7/12 versus 1/12 respectively (p=0.03). For Group A, 6/7 local recurrences clearly contacted a large vessel.
  
  
  CONCLUSIONS
  The cooling effect from flowing blood in large vessels markedly increases the rate of local failure of radiofrequency ablation for small HCC located near large vessels.
authors: Service de Radiologie, Hôpital Jean Verdier, Assistance Publique-Hôpitaux de Paris, avenue du 14 Juillet, 93140 Bondy. olivier.seror@jvr.aphp.fr
authors: O
authors: O
authors: Seror
authors: G
authors: G
authors: N'Kontchou
authors: M
authors: M
authors: Muhammad
authors: C
authors: C
authors: Barrucand
authors: M
authors: M
authors: Tin Tin Htar
authors: M
authors: M
authors: Assaban
authors: D
authors: D
authors: Haddar
authors: J C
authors: JC
authors: Trinchet
authors: M
authors: M
authors: Beaugrand
authors: N
authors: N
authors: Sellier
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000601:surgery*; D016022:Case-Control Studies; D017115:Catheter Ablation / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008099:Liver / Q000098:blood supply; D008102:Liver Circulation / Q000502:physiology*; D008113:Liver Neoplasms / Q000098:blood supply / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D018365:Neoplasm, Residual; D012039:Regional Blood Flow / Q000502:physiology; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome