Complex multidrug therapy in a patient with pulmonary hypertension before and after orthotopic heart transplantation. A case report.
Pulmonary arterial hypertension represents an absolute contraindication for heart transplantation. We report the case of a 30-year-old man with end-stage heart failure due to restrictive cardiomyopathy and pulmonary arterial hypertension. A complex multidrug therapy improved pulmonary haemodynamics to the point that orthotopic heart transplantation could be carried out. At 18-month follow-up after heart transplantation, the patient's cardiac function made a full recovery. Larger prospective studies are warranted to support these results.
D'Alto
Michele
M
Department of Cardiology, Second University of Naples, Monaldi Hospital, Via D. Fontana 81, Naples, Italy. mic.dalto@tin.it
Alfano
Dionigia
D
Maiello
Ciro
C
Sarubbi
Berardo
B
Santoro
Giuseppe
G
Argiento
Paola
P
Galdieri
Nicola
N
Russo
Maria G
MG
Cotrufo
Maurizio
M
Calabrò
Raffaele
R
D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D000077300:Bosentan; D006328:Cardiac Catheterization; D002313:Cardiomyopathy, Restrictive / Q000150:complications / Q000503:physiopathology; D000075202:Contraindications; D004359:Drug Therapy, Combination; D011464:Epoprostenol / Q000008:administration & dosage*; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D016027:Heart Transplantation; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D013449:Sulfonamides / Q000008:administration & dosage*
D000959:Antihypertensive Agents; D013449:Sulfonamides; D011464:Epoprostenol; D000077300:Bosentan