title: Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula.
abstract: Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula.
authors: Division of Microbiology, Armed Forces Institute of Pathology, Washington, DC, USA.
authors: M P
authors: MP
authors: Dempsey
authors: M
authors: M
authors: Dobson
authors: C
authors: C
authors: Zhang
authors: M
authors: M
authors: Zhang
authors: C
authors: C
authors: Lion
authors: C B
authors: CB
authors: Gutiérrez-Martín
authors: P C
authors: PC
authors: Iwen
authors: P D
authors: PD
authors: Fey
authors: M E
authors: ME
authors: Olson
authors: D
authors: D
authors: Niemeyer
authors: S
authors: S
authors: Francesconi
authors: R
authors: R
authors: Crawford
authors: M
authors: M
authors: Stanley
authors: J
authors: J
authors: Rhodes
authors: D M
authors: DM
authors: Wagner
authors: A J
authors: AJ
authors: Vogler
authors: D
authors: D
authors: Birdsell
authors: P
authors: P
authors: Keim
authors: A
authors: A
authors: Johansson
authors: S H
authors: SH
authors: Hinrichs
authors: A K
authors: AK
authors: Benson
mesh_terms: D016000:Cluster Analysis; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D004587:Electrophoresis, Agar Gel; D005602:France; D005603:Francisella / Q000235:genetics / Q000302:isolation & purification; D005604:Francisella tularensis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D017353:Gene Deletion; D005798:Genes, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D016133:Polymerase Chain Reaction; D013030:Spain; D013045:Species Specificity
chemical_list: D004269:DNA, Bacterial