title: First desymmetrization of 1,3-propanediamine derivatives in organic solvent. Development of a new route for the preparation of optically active amines.
abstract: The chemical synthesis and enzymatic desymmetrization of a panel of prochiral diamines have been successfully described for the first time using lipases in organic solvents. A family of 2-aryl-1,3-propanediamines has been obtained with high enantiopurity and good yields in the PSL-catalyzed reaction using diallyl carbonate in 1,4-dioxane.
authors: Departamento de Química OrgAnica e InorgAnica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, Oiedo E-33071, Spain.
authors: Eduardo
authors: E
authors: Busto
authors: Vicente
authors: V
authors: Gotor-Fernández
authors: Jose
authors: J
authors: Montejo-Bernardo
authors: Santiago
authors: S
authors: Gárcía-Granda
authors: Vicente
authors: V
authors: Gotor
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003959:Diamines / Q000737:chemistry*; D005656:Fungal Proteins; D008049:Lipase / Q000378:metabolism*; D008968:Molecular Conformation; D015394:Molecular Structure; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D000588:Amines; D003959:Diamines; D005656:Fungal Proteins; D012997:Solvents; D008049:Lipase; C431349:lipase B, Candida antarctica