Modeling parkinsonian circuitry and the DBS electrode. I. Biophysical background and software.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) has become routine over the past decade, utilizing microelectrode recordings to ensure accurate placement of the stimulating electrodes. The clinical benefits of STN DBS for PD are well documented, but the mechanisms by which DBS achieves these results remain elusive. We have created a closed-form mathematical function of the potential field generated by a typical 4-contact DBS electrode and inserted this function into a computational model designed to simulate individual neurons and neural circuitry of significant portions of the basal ganglia. We present the mathematical function representing the potential field itself and the basis for the neural circuitry modeling in this paper.
Arle
J E
JE
Department of Neurosurgery, Lahey Clinic, Burlington, MA 01805, USA. jeffrey.arle@lahey.org
Mei
L Z
LZ
Shils
J L
JL
D000818:Animals; D001703:Biophysics / Q000295:instrumentation / Q000379:methods; D046690:Deep Brain Stimulation / Q000295:instrumentation* / Q000379:methods*; D004566:Electrodes / Q000592:standards; D006801:Humans; D008959:Models, Neurological; D009431:Neural Conduction / Q000502:physiology; D016571:Neural Networks, Computer; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy; D012984:Software / Q000592:standards; D020531:Subthalamic Nucleus / Q000502:physiology