DC homeostasis in hematopoietic stem cell transplantation.
Hematopoietic stem cell transplantation is an important experimental tool and therapeutic modality. Its efficacy and toxicity are both linked to a GvH reaction that is initiated by donor T cells recognizing recipient APC, of which DC are the most potent. In most tissues recipient DC are replaced after transplantation because they turnover rapidly from BM-derived precursors. However, in a number of sites, notably the skin, recipient DC may persist and even self-renew for many months after transplantation. Understanding the homeostasis of different APC populations and how they are related to the induction of alloreactivity may help to improve the therapeutic benefit of transplantation.
Collin
M P
MP
Department of Gene and Cell Medicine, Mount Sinai Medical School, New York, New York 10029, USA. matthew.collin@mssm.edu
Bogunovic
M
M
Merad
M
M
D000818:Animals; D000938:Antigen-Presenting Cells / Q000166:cytology; D003713:Dendritic Cells / Q000502:physiology*; D006087:Graft vs Host Reaction; D018380:Hematopoietic Stem Cell Transplantation; D006706:Homeostasis; D006801:Humans