Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics.
A total of 223 complete bacterial genomes are analyzed, with 281 citations, for the presence of genes encoding modular polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS). We report on the distribution of these systems in different bacterial taxa and, whenever known, the metabolites they synthesize. We also highlight, in the different bacterial lineages, the PKS and NRPS genes and, whenever known, the corresponding products.
Donadio
Stefano
S
KtedoGen, via Fantoli 16/15, 20132 Milan, Italy. stefano.donadio@ktedogen.com
Monciardini
Paolo
P
Sosio
Margherita
M
D016680:Genome, Bacterial; D015394:Molecular Structure; D010453:Peptide Synthases / Q000378:metabolism; D048630:Polyketide Synthases / Q000378:metabolism
D048630:Polyketide Synthases; D010453:Peptide Synthases