Primary sinonasal undifferentiated carcinoma presenting with bilateral retrobulbar optic neuropathy.
A 43-year-old man presented with acute bilateral visual loss. Ophthalmologic examination revealed no light perception in the right eye and a visual acuity of 20/50 in the left eye with a right afferent pupillary defect. Ophthalmoscopic examination was normal. Brain MRI showed an intracranial but extra-axial mass in the floor of the anterior cranial fossa extending along the olfactory groove and into the sinonasal vault. Endoscopic biopsy showed a high-grade neoplasm consistent with sinonasal undifferentiated carcinoma. This case report highlights an unusual clinical presentation for this rare and aggressive neoplasm.
Tamhankar
Madhura A
MA
Division of Neuro-ophthalmology, Scheie Eye Institute, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, 51 North 39th Street, Philadelphia, PA 19104, USA.
Volpe
Nicholas J
NJ
Loevner
Laurie A
LA
Palmer
James N
JN
Feldman
Michael
M
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D001706:Biopsy; D002277:Carcinoma / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D035262:Cranial Fossa, Anterior / Q000473:pathology / Q000503:physiopathology; D017809:Fatal Outcome; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009296:Nasal Cavity / Q000473:pathology / Q000503:physiopathology; D009362:Neoplasm Metastasis / Q000473:pathology; D009900:Optic Nerve / Q000473:pathology / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D009915:Orbit / Q000473:pathology / Q000503:physiopathology; D010255:Paranasal Sinus Neoplasms / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D010256:Paranasal Sinuses / Q000473:pathology / Q000503:physiopathology; D011878:Radiotherapy; D017211:Treatment Failure; D015354:Vision, Low / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology
D014408:Biomarkers, Tumor