title: Synthesis and DNA-cleavage properties of metal complexes of 1,4,7,10-tetraazacyclododecane (cyclen) functionalized with a pendant benzocrown ether.
abstract: The synthesis and DNA-cleavage properties of a series of novel mononuclear Zn(II), Cu(II), and Co(II) complexes 2 of a crown-ether-functionalized cyclen ligand is described. The Cu complex 2b displayed the highest catalytic activity towards pUC 19 DNA. The effects of reaction time, complex concentration, and pH were investigated, showing that 2b readily and efficiently converts supercoiled (type I ) plasmid DNA to nicked (type II) DNA under physiological conditions (37 degrees, pH 7.4).
authors: Department of Chemistry, Key Laboratory of Green Chemistry and Technology, (Ministry of Education), Sichuan University, Chengdu 610064, PR China.
authors: Xin-Yu
authors: XY
authors: Tan
authors: Ji
authors: J
authors: Zhang
authors: Yu
authors: Y
authors: Huang
authors: Yu
authors: Y
authors: Zhang
authors: Li-Hong
authors: LH
authors: Zhou
authors: Ning
authors: N
authors: Jiang
authors: Hong-Hui
authors: HH
authors: Lin
authors: Na
authors: N
authors: Wang
authors: Chuan-Qin
authors: CQ
authors: Xia
authors: Xiao-Qi
authors: XQ
authors: Yu
mesh_terms: D002384:Catalysis; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D000080027:Cyclams; D053837:DNA Cleavage; D004278:DNA, Superhelical / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
chemical_list: C524279:(2,3,5,6,8,9,11,12-octahydro-N-(3-(1,4,7,10-tetraazacyclododec-1-yl)propyl)-1,4,7,10,13-benzopentaoxacyclopentadecin-15-amine)copper(II); D000080027:Cyclams; D004278:DNA, Superhelical; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D003035:Cobalt; D003300:Copper; C038072:cyclen; D015032:Zinc