[Diagnostic value of serum amyloid A protein (SAA) determination].
Although serum amyloid A (SAA) was discovered almost 25 years ago, its biological role is still unknown. Similarly to C-reactive protein, SAA belongs to acute reaction proteins, synthesised in the liver after stimulation by proinflammatory cytokines like: TNFalpha, IL-1beta and IL-6. SAA level in acute inflammatory process of bacterial, mycotical, autoimmunological, oncological or extensive tissue damage is from 100 to 1000 mg/l. Additional SAA examination in patients with oncological disorders is accepted as a valuable survival index.
Kuśnierz-Cabala
Beata
B
Zakład Diagnostyki Katedra Biochemii, Klinicznej Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie. mbkusnie@cyf-kr.edu.pl
Galicka-Latała
Danuta
D
Naskalski
Jerzy W
JW
D015415:Biomarkers / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis / Q000096:biosynthesis; D006801:Humans; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D000685:Serum Amyloid A Protein / Q000032:analysis* / Q000096:biosynthesis*
D015415:Biomarkers; D014408:Biomarkers, Tumor; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein