title: Bioaccumulation and toxicity of a cationic surfactant (DODMAC) in sediment dwelling freshwater invertebrates.
abstract: Dimethyldioctadecylammonium chloride (DODMAC, CAS No. 107-64-2) is the principal active component of Di(hydrogenated tallow alkyl) dimethylammonium chloride (DHTDMAC, CAS No. 61789-80-8), a cationic surfactant formerly used principally in laundry fabric softeners. After discharge to water, DODMAC partitions strongly to sediment, therefore the assessment of the effects of DODMAC to benthic organisms is essential in any risk assessment. Chronic toxicity studies were conducted with Lumbriculus variegatus (Oligochaete), Tubifex tubifex (Oligochaete) and Caenorhabditis elegans (Nematode). NOECs were greater than 5738, 1515 and 1351 mg/kg dw, respectively, even for sub-lethal effects. Measurement of the route of uptake of DODMAC by L. variegatus demonstrated the relative importance of uptake via ingestion (86%) compared with direct contact with the sediment and via pore water (14%). The overall tendency of DODMAC to bioaccumulate, however, was low with measured accumulation factors of 0.22 and 0.78 for L. variegatus and T. tubifex, respectively.
authors: Atkins Ltd, Chilbrook, Oasis Business Park, Eynsham, Oxford, UK. sean.comber@atkinsglobal.com
authors: S D W
authors: SD
authors: Comber
authors: K L
authors: KL
authors: Rule
authors: A U
authors: AU
authors: Conrad
authors: S
authors: S
authors: Höss
authors: S F
authors: SF
authors: Webb
authors: S
authors: S
authors: Marshall
mesh_terms: D033304:Amphipoda / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000378:metabolism; D005618:Fresh Water; D007448:Invertebrates / Q000187:drug effects* / Q000378:metabolism; D019055:No-Observed-Adverse-Effect Level; D009835:Oligochaeta / Q000187:drug effects / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000493:pharmacokinetics / Q000633:toxicity*; D013501:Surface-Active Agents / Q000493:pharmacokinetics / Q000633:toxicity*; D036401:Toxicity Tests, Chronic; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; D014874:Water Pollutants, Chemical; C473737:dioctyldimethyl ammonium chloride