Establishment of a proneural field in the inner ear.
Hair-cells, supporting cells and sensory neurons are the main specialized cell-types responsible for mechanotransduction in the inner ear. They derive from precursors expressing proneural genes and recent data has underlined the importance of SoxB1 genes as upstream activators of proneural genes during cranial placode development. Here we review the steps of establishing a proneural field and propose several models for how early otic regionalization into a proneural territory is achieved.
Abello
Gina
G
Developmental Biology, Dept. of Experimental Sciences and Health, Pompeu Fabra University, Barcelona Biomedical Research Park, Barcelona, Spain.
Alsina
Berta
B
D000818:Animals; D007758:Ear, Inner / Q000166:cytology* / Q000196:embryology* / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000378:metabolism; D004627:Embryonic Induction; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006198:Hair Cells, Auditory / Q000378:metabolism; D007760:Labyrinth Supporting Cells / Q000166:cytology / Q000378:metabolism; D040542:Mechanotransduction, Cellular; D008954:Models, Biological; D009475:Neurons, Afferent / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D051880:Receptors, Notch; D014157:Transcription Factors; D005346:Fibroblast Growth Factors