[Experimental studies for the improvement of facial nerve regeneration].
Using a combination of the following, it is possible to investigate procedures to improve the morphological and functional regeneration of the facial nerve in animal models: 1) retrograde fluorescence tracing to analyse collateral axonal sprouting and the selectivity of reinnervation of the mimic musculature, 2) immunohistochemistry to analyse both the terminal axonal sprouting in the muscles and the axon reaction within the nucleus of the facial nerve, the peripheral nerve, and its environment, and 3) digital motion analysis of the muscles. To obtain good functional facial nerve regeneration, a reduction of terminal sprouting in the mimic musculature seems to be more important than a reduction of collateral sprouting at the lesion site. Promising strategies include acceleration of nerve regeneration, forced induced use of the paralysed face, mechanical stimulation of the face, and transplantation of nerve-growth-promoting olfactory epithelium at the lesion site.
Guntinas-Lichius
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Klinik und Poliklinik für Hals-, Nasen-, Ohrenkranke, Friedrich-Schiller-Universität, Lessingstrasse 2, 07740 Jena. orlando.guntinas@med.uni-jena.de
Angelov
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D000818:Animals; D001369:Axons / Q000502:physiology; D005152:Facial Muscles / Q000294:innervation*; D005154:Facial Nerve / Q000473:pathology / Q000503:physiopathology*; D020220:Facial Nerve Injuries / Q000473:pathology / Q000503:physiopathology; D005158:Facial Paralysis / Q000628:therapy; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D018715:Microscopy, Video; D008866:Microsurgery / Q000379:methods; D009046:Motor Neurons / Q000473:pathology / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D009831:Olfactory Mucosa / Q000637:transplantation; D010812:Physical Stimulation; D051381:Rats; D012183:Retrograde Degeneration / Q000473:pathology; D014738:Vibrissae / Q000294:innervation; D014741:Video Recording
D036341:Intercellular Signaling Peptides and Proteins