title: [Modern strains of Bordetella pertussis: immunobiological properties and vaccine improvement].
abstract: Strains of B. pertussis isolated from patients in Moscow in 2001-2005 as well as strains included in locally produced diphtheria-tetanus-whole cell pertussis (DTP) vaccine were studied. Nucleotide sequences in genes of pertactin and S1-subunit of pertussis toxin of isolated strains, their immunobiological properties and opportunity to use for producing of the acellular pertussis vaccine were determined. Genes of pertactin and S1-subunit of pertussis toxin in the isolated wild strains differed from the same genes in strains included in the local DTP vaccine. Majority of the isolated strains belonged to serotype 1.0.3 and were markedly virulent.
authors: A S
authors: AS
authors: Shinkarev
authors: N U
authors: NU
authors: Mertsalova
authors: I K
authors: IK
authors: Mazurova
authors: O Iu
authors: OIu
authors: Borisova
authors: N S
authors: NS
authors: Zakharova
authors: M N
authors: MN
authors: Ozeretskovskaia
authors: E M
authors: EM
authors: Zaĭtsev
authors: A V
authors: AV
authors: Poddubikov
authors: M V
authors: MV
authors: Britsina
authors: I G
authors: IG
authors: Bazhanova
mesh_terms: D000483:Alleles; D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000276:immunology; D001426:Bacterial Proteins / Q000032:analysis / Q000235:genetics; D001483:Base Sequence; D001886:Bordetella pertussis / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D051379:Mice; D009031:Moscow; D037342:Pertussis Toxin / Q000032:analysis / Q000235:genetics / Q000276:immunology; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D021122:Protein Subunits / Q000235:genetics / Q000276:immunology; D012703:Serotyping; D014611:Vaccination; D014774:Virulence; D010566:Virulence Factors, Bordetella / Q000235:genetics / Q000276:immunology; D014917:Whooping Cough / Q000382:microbiology* / Q000517:prevention & control
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D010567:Pertussis Vaccine; D021122:Protein Subunits; D010566:Virulence Factors, Bordetella; C068929:pertactin; D037342:Pertussis Toxin