title: Coenzyme biosynthesis: enzyme mechanism, structure and inhibition.
abstract: This review highlights five key reactions in vitamin biosynthesis and in particular focuses on their mechanisms and inhibition and insights from structural studies. Each of the enzymes has the potential to be a target for novel antimicrobial agents.
authors: University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.
authors: Duncan E
authors: DE
authors: Scott
authors: Alessio
authors: A
authors: Ciulli
authors: Chris
authors: C
authors: Abell
mesh_terms: D000890:Anti-Infective Agents; D003067:Coenzymes / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D004798:Enzymes / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D014815:Vitamins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D003067:Coenzymes; D004798:Enzymes; D014815:Vitamins