Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study.
Common polymorphisms in the CRP gene are associated with plasma CRP levels in population-based studies, but associations with age-related events are uncertain. A previous study of CRP haplotypes in older adults was broadened to include longevity and cause-specific mortality (all-cause, noncardiovascular (non-CV), and cardiovascular (CV)). Common haplotypes were inferred from four tagSNPs in 4512 whites and five tagSNPs in 812 blacks from the Cardiovascular Health Study, a longitudinal cohort of adults over age 65. Exploratory analyses addressed early versus late mortality. CRP haplotypes were not associated with all-cause mortality or longevity overall in either population, but associations with all-cause mortality differed during early and late periods. In blacks, the haplotype tagged by 3872A (rs1205) was associated with increased risk of non-CV mortality, relative to other haplotypes (adjusted hazard ratio for each additional copy: 1.42, 95% CI: 1.07, 1.87). Relative to other haplotypes, this haplotype was associated with decreased risk of early but not decreased risk of late CV mortality in blacks; among whites, a haplotype tagged by 2667C (rs1800947) gave similar but nonsignificant findings. If confirmed, CRP genetic variants may be weakly associated with CV and non-CV mortality in older adults, particularly in self-identified blacks.
Hindorff
Lucia A
LA
Department of Epidemiology, University of Washington, Seattle, WA, United States. lah@u.washington.edu
Rice
Kenneth M
KM
Lange
Leslie A
LA
Diehr
Paula
P
Halder
Indrani
I
Walston
Jeremy
J
Kwok
Pui
P
Ziv
Elad
E
Nievergelt
Caroline
C
Cummings
Steven R
SR
Newman
Anne B
AB
Tracy
Russell P
RP
Psaty
Bruce M
BM
Reiner
Alexander P
AP
D001741:Black or African American / Q000235:genetics*; D000368:Aged; D002097:C-Reactive Protein / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000208:ethnology / Q000235:genetics / Q000401:mortality; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D016014:Linear Models; D008136:Longevity / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016016:Proportional Hazards Models; D014481:United States
D002097:C-Reactive Protein