Insights into the mechanisms of histamine-induced inflammation in the nasal mucosa.
Histamine is a major autacoid released during allergic reactions. Histamine, when administered to the nasal mucosa, causes symptoms that mimic allergic rhinitis, including nasal blockage, sneezing, pruritus and rhinorrhea. This article provides an overview of the contribution of H1, H2 and H3 receptors to histamine-induced symptom generation, in particular focusing on nasal blockage.
Taylor-Clark
Thomas E
TE
School of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. ttaylor-clark@jhmi.edu <ttaylor-clark@jhmi.edu>
D000818:Animals; D006632:Histamine / Q000633:toxicity*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced* / Q000473:pathology*; D009297:Nasal Mucosa / Q000473:pathology*; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000502:physiology; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000502:physiology; D018100:Receptors, Histamine H3 / Q000187:drug effects / Q000502:physiology
D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D018100:Receptors, Histamine H3; D006632:Histamine