title: Effect of preoperative mild renal dysfunction on mortality and morbidity following valve cardiac surgery.
abstract: The objective of this study was to investigate the effect of preoperative mild renal dysfunction (RD) not requiring dialysis on mortality and morbidity after valve cardiac surgery (VCS). We studied 681 consecutive patients (2002-2006) who underwent valve cardiac surgery with or without coronary artery bypass graft (CABG). Preoperative RD was calculated with the abbreviated Modification of Diet in Renal Disease formula and was defined as a glomerular filtration rate <60 ml/min/1.73 m(2). Logistic regression analysis was used to assess the effect of preoperative renal dysfunction on operative and adverse outcomes. Two hundred and seven patients (30%) had preoperative mild RD. Patients with preoperative RD were older, had a higher rate of preoperative anaemia (43% vs. 25%, P<0.001) and more comorbidities. Patients with preoperative RD had worse outcomes with more reoperation (6.8% vs. 2.3%, P<0.001). Preoperative RD was significantly and independently associated with more red blood cell transfusions and longer hospital stay (median 9 vs. 8 days, P<0.001). Mortality was similar in both groups (3.4% vs. 2.3%, P=0.43). Preoperative mild renal dysfunction in patients undergoing cardiac valve surgery is an independent marker of postoperative morbidity.
authors: Intensive Care Unit and Cardiac Surgery Department, Hospital Universitario Son Dureta, c/Andrea Doria 55, 07014 Palma de Mallorca, Illes Balears, Spain. jibanez@hsd.es
authors: Jorge
authors: J
authors: Ibáñez
authors: Maria
authors: M
authors: Riera
authors: José Ignacio
authors: JI
authors: Saez de Ibarra
authors: Andrés
authors: A
authors: Carrillo
authors: Ruben
authors: R
authors: Fernández
authors: Jaime
authors: J
authors: Herrero
authors: Miguel
authors: M
authors: Fiol
authors: Oriol
authors: O
authors: Bonnin
mesh_terms: D000368:Aged; D000740:Anemia / Q000209:etiology / Q000401:mortality; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D017707:Erythrocyte Transfusion; D005260:Female; D005919:Glomerular Filtration Rate; D006349:Heart Valve Diseases / Q000150:complications / Q000401:mortality* / Q000601:surgery*; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000150:complications* / Q000401:mortality* / Q000503:physiopathology; D012086:Reoperation; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome