title: Headaches add to the burden of epilepsy.
abstract: The objective was to investigate and classify headaches in 109 consecutive adult patients with epilepsy. A semi-structured interview was performed in those who confirmed such symptoms (65%). Interictal headaches were present in 52%; 20% had interictal migraine. Postictal headache was reported in 44%. Migraine characteristics were present in 42% of these, and most of them (74%) also suffered from interictal migraine. Six percent had preictal headache. In partial epilepsy, there was an association between headache lateralisation and interictal EEG abnormalities (p=0.02). We conclude that headache, including migraine, is very common in patients with epilepsy. Unilateral headache may represent a lateralising sign in focal epilepsy. Seizures often trigger postictal headaches with migraine features, which often are associated with interictal migraine. Migrainous headaches sometimes proceed into epileptic seizures. The comorbidity of migraine and epilepsy should receive ample clinical attention, as it may influence antiepileptic drug choice, and the headache may need specific treatment.
authors: Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
authors: Marte
authors: M
authors: Syvertsen
authors: Grethe
authors: G
authors: Helde
authors: Lars Jacob
authors: LJ
authors: Stovner
authors: Eylert
authors: E
authors: Brodtkorb
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000503:physiopathology; D015331:Cohort Studies; D015897:Comorbidity; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D004827:Epilepsy / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006261:Headache / Q000145:classification / Q000453:epidemiology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000453:epidemiology / Q000503:physiopathology; D011237:Predictive Value of Tests; D015995:Prevalence; D012680:Sensitivity and Specificity
chemical_list: D000927:Anticonvulsants