Bioelectronome. Integrated approach to receptor chemistry, radicals, electrochemistry, cell signaling, and physiological effects based on electron transfer.
Bioelectronome refers to the host of electron transfer (ET) reactions that occur in living systems. This review presents an integrated approach to receptor chemistry based on electron transfer, radicals, electrochemistry, cell signaling, and end result. First, receptor activity is addressed from the unifying standpoint of redox transformations in which various receptors are discussed. After a listing of receptor-binding modes, receptor chemistry is treated with focus on generation of reactive oxygen species (ROS), activation by ROS, and subsequent cell signaling involving ROS. A general electrostatic mechanism is proposed for receptor-ligand action with supporting evidence. Cell-signaling processes appear to entail electron transfer, ROS, redox chains, and relays. The widespread involvement of phosphate from phosphorylation may be rationalized electrostatically by analogy with DNA phosphate. Extensive evidence supports important participation of ET functionalities in the mechanism of drugs and toxins. The integrated approach is applied to the main ET classes, namely, quinones, metal complexes, iminium species, and aromatic nitro compounds.
Kovacic
Peter
P
Department of Chemistry, San Diego State University, San Diego, California 92182, USA. pkovacic@sundown.sdsu.edu
Pozos
Robert S
RS
D000109:Acetylcholine / Q000737:chemistry; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004563:Electrochemistry / Q000379:methods*; D004583:Electrons; D004967:Estrogens / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D008024:Ligands; D018482:Muscle, Skeletal / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism; D015398:Signal Transduction
D002395:Catecholamines; D004967:Estrogens; D005609:Free Radicals; D008024:Ligands; D011950:Receptors, Cholinergic; D017470:Receptors, Glutamate; D019837:Ryanodine Receptor Calcium Release Channel; D000109:Acetylcholine