title: Macrocyclic diketopiperazine receptors: effect of macrocyclization on the binding properties of two-armed receptors.
abstract: The synthesis of macrocyclic two-armed diketopiperazine receptors and their binding properties toward peptides is described. Macrocyclization with short linkers led to receptors with significantly modified binding properties compared to their flexible open chain parent receptors, whereas with long linkers the original binding selectivities were largely retained.
authors: Department of Chemistry, University of Basel, St. Johanns Ring 19, CH-4056 Basel, Switzerland.
authors: Jessica
authors: J
authors: Bernard
authors: Helma
authors: H
authors: Wennemers
mesh_terms: D000595:Amino Acid Sequence; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D054659:Diketopiperazines / Q000737:chemistry*; D015394:Molecular Structure; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D018000:Receptors, Peptide / Q000737:chemistry* / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D054659:Diketopiperazines; D019151:Peptide Library; D010455:Peptides; D018000:Receptors, Peptide