TrkC: a new predictive marker in breast cancer?
Available data involve neurotrophins and their receptors in carcinomas. Quantitative evaluation of these molecules in these tumors might be useful as prognostic marker and eventual treatments. Our study on 40 mammary tumors tries to correlate expression of these molecules and prognosis. Immunohistochemistry for NGF, BDNF, NT3, TrkA, TrkB, TrkC, and p75 was used. Patient's age, histopathology, Bloom-Richardson grading, estrogen and progesterone receptors, Ki-67 index, HER-2, p53 were evaluated. Statistics found inverse relationship between grading and TrkC expression. We found significantly higher TrkC expression in Grade I than in Grade III tumors. Rise in TrkC expression could indicate good prognosis.
Blasco-Gutiérrez
María Jesús
MJ
Pathology Department, Facultad de Medicina-Universidad de Valladolid, Valladolid, Spain.
José-Crespo
Isabel Julia San
IJ
Zozaya-Alvarez
Enrique
E
Ramos-Sánchez
Rafael
R
García-Atarés
Natividad
N
D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D009414:Nerve Growth Factors / Q000032:analysis; D011379:Prognosis; D020812:Receptor, trkC / Q000032:analysis*
D014408:Biomarkers, Tumor; D009414:Nerve Growth Factors; D020812:Receptor, trkC