title: (1)H and (13)C NMR assignments for five anthraquinones from the mangrove endophytic fungus Halorosellinia sp. (No. 1403).
abstract: We report the unambiguous assignments of the (1)H and (13)C NMR spectra of two new natural products, namely, 1,4,5,6,7,9-hexahydroxy-2-methoxy-7-methyl-5beta,9beta,8abeta, 6alpha,10aalpha-hexahydroanthracen-10 (10aH)-one (1) and 1,4,6-trihydroxy-2-methoxy-7-methylanthracene-9, 10-dione (2), together with three known anthraquinones. These compounds were all isolated from the marine endophytic fungus No. 1403 collected from the South China Sea. Compounds 3 and 4 were isolated from the marine fungus for the first time. The structures were elucidated by the spectroscopic methods 1D and 2D NMR including COSY, HMQC, HMBC and NOE, and HREIMS. In our cytotoxicity assays, compound 5 showed cytotoxicity toward KB and KBv-200 cells with IC(50) of 1.40 and 2.58 microg/ml, respectively. In addition, the plausible biogenic relationship of compounds 1, 2, 3 and 4 is discussed.
authors: School of Chemistry and Chemical Engineering, Sun Yat-sen (Zhongshan) University, Guangzhou 510275, P. R. China.
authors: Xue-Kui
authors: XK
authors: Xia
authors: Hua-Rong
authors: HR
authors: Huang
authors: Zhi-Gang
authors: ZG
authors: She
authors: Chang-Lun
authors: CL
authors: Shao
authors: Fan
authors: F
authors: Liu
authors: Xiao-Ling
authors: XL
authors: Cai
authors: L L P
authors: LL
authors: Vrijmoed
authors: Yong-Cheng
authors: YC
authors: Lin
mesh_terms: D000880:Anthraquinones / Q000737:chemistry*; D002247:Carbon Isotopes; D005658:Fungi / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D011522:Protons
chemical_list: D000880:Anthraquinones; D002247:Carbon Isotopes; D011522:Protons