title: RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection.
abstract: Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.
authors: Institute of Infectious Diseases and Public Health, Polytechnic University of the Marche Region, A.O. Ospedali Riuniti, Ancona, Italy. anconacmi@interfree.it
authors: Oscar
authors: O
authors: Cirioni
authors: Roberto
authors: R
authors: Ghiselli
authors: Daniele
authors: D
authors: Minardi
authors: Fiorenza
authors: F
authors: Orlando
authors: Federico
authors: F
authors: Mocchegiani
authors: Carmela
authors: C
authors: Silvestri
authors: Giovanni
authors: G
authors: Muzzonigro
authors: Vittorio
authors: V
authors: Saba
authors: Giorgio
authors: G
authors: Scalise
authors: Naomi
authors: N
authors: Balaban
authors: Andrea
authors: A
authors: Giacometti
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D004195:Disease Models, Animal; D005260:Female; D010455:Peptides / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D015607:Stents / Q000382:microbiology*; D017334:Teicoplanin / Q000494:pharmacology; D014513:Ureter / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D012329:RNA, Bacterial; C096035:RNAIII, Staphylococcus aureus; D017334:Teicoplanin