Patient response in a screened population for interstitial cystitis.
The purpose of this study was to screen a general patient population for interstitial cystitis (IC) and to determine the outcome of combination therapy (pentosan polysulfate sodium [PPS] and hydroxyzine) in newly diagnosed patients. Screening for IC symptoms was performed on 3883 patients (>or=18 yr of age). After further evaluation, a diagnosis of IC was made in 160 patients. These patients were subsequently treated with PPS 200 mg twice a day (off-label usage) and hydroxyzine hydrochloride 25 mg nightly for 1 to 12 mo. Clinically meaningful (>or=50%) improvement in IC symptoms, as measured by the Patient's Overall Rating of Improvement of Symptoms index, was reported by 59 of 122 patients (48.4%) who completed 1 mo of therapy. This effect was sustained for 12 mo in 26 of 28 patients (92.9%) completing the study. The combination of PPS and hydroxyzine hydrochloride was well tolerated and effective in relieving symptoms associated with IC.
Rosenberg
Matt T
MT
Mid-Michigan Health Centers, 214 North West Avenue, Jackson, MI, 49201, USA. matttoren@yahoo.com
Hazzard
Matthew A
MA
Page
Sharyl A
SA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018856:Cystitis, Interstitial / Q000175:diagnosis* / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D000925:Anticoagulants; D006634:Histamine H1 Antagonists; D006919:Hydroxyzine; D010426:Pentosan Sulfuric Polyester