title: Factors related to surgical complications and their impact on the functional status in 236 open surgeries for malignant tumors in a Latino-American hospital.
abstract: BACKGROUND
  There are not many studies that address the selection of patients harboring malignant brain tumors for open surgery. It is necessary, especially in developing countries, to establish the standards because of their impact not only on the efficacy but also on the cost-effectiveness of surgery. With the concern to add information that may help in future studies about the decision making, we proposed to analyze factors associated with surgical complications and evaluate their influence on the functional status at 30 days after surgery.
  
  
  METHODS
  A consecutive series of 236 surgeries performed between June 1999 and June 2005 were retrospectively analyzed (168 gliomas, 65 metastases, 3 others). Variables evaluated were age, sex, pre- and postoperative KPS, ASA status, anatomic localization, extent of tumor resection, tumor histology, and number of surgeries.
  
  
  RESULTS
  The incidence of complicated craniotomies was 15.68% and mortality was 2.97%. Postoperatively, 92% of the patients improved or maintained the functional status, whereas 8% worsened. In multivariate analysis, only preoperative KPS (P = .009), ASA status (P = .02), and histology type (P = .03) showed significant association with postoperative complications.
  
  
  CONCLUSIONS
  We found that the neurologic and clinical preoperative condition and grade III gliomas were factors related to postoperative complications, whereas age, extent of resection, and number of surgeries were not risk factors. We believe that these conclusions provide an additional benchmark for future multicentric studies that focus on the selection criteria for resection of malignant brain tumors.
authors: Service of Neurosurgery, Hospital Italiano of Buenos Aires, 1181 Buenos Aires, Argentina. alejandrarabadan@speedy.com.ar
authors: Alejandra T
authors: AT
authors: Rabadán
authors: Diego
authors: D
authors: Hernandez
authors: Martin
authors: M
authors: Eleta
authors: Marcelo
authors: M
authors: Pietrani
authors: Matteo
authors: M
authors: Baccanelli
authors: Silvia
authors: S
authors: Christiansen
authors: Carlos
authors: C
authors: Teijido
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000627:therapeutic use; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D003399:Craniotomy / Q000009:adverse effects; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status; D007843:Latin America / Q000453:epidemiology; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000453:epidemiology / Q000209:etiology; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D018579:Patient Selection; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011183:Postoperative Complications / Q000453:epidemiology* / Q000401:mortality; D012086:Reoperation; D012727:Sex Characteristics; D053828:Stockings, Compression
chemical_list: D000927:Anticonvulsants; D010975:Platelet Aggregation Inhibitors