title: Waist circumference is strongly associated with renal resistive index in normoalbuminuric patients with type 2 diabetes.
abstract: OBJECTIVE
  Anthropometric parameters may play a role in modulating the risk of kidney dysfunction. The aim of this study was to evaluate whether anthropometric indices and the metabolic syndrome are associated with alterations of the renal resistive index (RI) in normoalbuminuric type 2 diabetic (T2DM) patients.
  
  
  METHODS
  A sample of 99 consecutively recruited patients with T2DM (76 male and 23 female) was examined. The RI was assessed by duplex Doppler sonography.
  
  
  RESULTS
  In univariate analysis, a significant association between the RI values and age (r = 0.507, p < 0.0001), gender (being higher in women, p = 0.002), systolic blood pressure (r = 0.285, p = 0.011), smoking habit (being lower in current smokers, p = 0.047), estimated glomerular filtration rate (r = -0.435, p < 0.0001), and intima-media thickness of the carotid arteries (r = 0.271, p = 0.020) was observed. As far as anthropometric parameters are concerned, a strong correlation between waist circumference (WC; r = 0.401, p < 0.0001), BMI (r = 0.337, p = 0.003) and RI values was found but only WC maintained a significant correlation after adjusting for several confounders (p = 0.001).
  
  
  CONCLUSIONS
  In normoalbuminuric T2DM patients, the intrarenal hemodynamic abnormalities seem primarily associated with WC.
authors: Unit of Endocrinology and Metabolic Diseases, Department of Medical Sciences, University of Foggia, Foggia, Italy.
authors: Olga
authors: O
authors: Lamacchia
authors: Vincenzo
authors: V
authors: Nicastro
authors: Donatella
authors: D
authors: Camarchio
authors: Giovanni
authors: G
authors: Stallone
authors: Loreto
authors: L
authors: Gesualdo
authors: Mauro
authors: M
authors: Cignarelli
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000453:epidemiology; D000886:Anthropometry; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D003928:Diabetic Nephropathies / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation; D012307:Risk Factors; D018616:Ultrasonography, Doppler, Duplex; D014655:Vascular Resistance