title: Comparison of dose contribution to normal pelvic tissues among conventional, conformal and intensity-modulated radiotherapy techniques in prostate cancer.
abstract: High-energy external radiotherapy has become one of the most common treatment in localized prostate cancer. We compared the difference of dose distribution, mainly at the 5-30 Gy dose level, in the irradiated pelvic volume among three modalities of radiotherapy for patients with prostate cancer: conventional, conformal and intensity-modulated radiotherapy (IMRT). We selected six patients with prostate cancer treated by conformal radiotherapy at the doses of 46 Gy to PTVN (prostate and seminal vesicles), and 70 Gy to PTV-T (prostate). The conventional technique": an 8-field arrangement was used; the conformal technique 4 fields with a boost through 6 fields. For IMRT, a five-beam arrangement was used. Dose-volume histograms (DVH) were analyzed and compared among the three techniques. The IMRT technique significantly increased the pelvic volume covered by the isodose surfaces below 15 Gy as compared with the conventional and conformal techniques. The mean absolute increase for the pelvic volume included between 5-30 Gy for the IMRT technique, was about 2 900 ml as compared with the conventional technique. However, IMRT significantly reduced the irradiated volume of the rectum in the dose range of 5 to 40 Gy, also significantly reduced the irradiated volume of bladder and femoral heads, and obtained a similar or improved isodose distribution in the PTVs. In addition, the use of IMRT slightly increased the relative dose delivered to the body volume outside the pelvis, as estimated by the use of specific software. A long-term follow-up will be needed to evaluate potential late treatment complications related to the use of IMRT and the low or moderate irradiation dose level obtained in the pelvis and in the whole body.
authors: Department of Radiotherapy, Institut Gustave-Roussy, Villejuif, France. tao@igr.fr
authors: Yungan
authors: Y
authors: Tao
authors: Dimitri
authors: D
authors: Lefkopoulos
authors: Diallo
authors: D
authors: Ibrahima
authors: Andre
authors: A
authors: Bridier
authors: Maria Del Pilar
authors: Mdel P
authors: Polizzi
authors: Pierre
authors: P
authors: Wibault
authors: Renaud
authors: R
authors: De Crevoisier
authors: Rodrigo
authors: R
authors: Arriagada
authors: Jean
authors: J
authors: Bourhis
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D005270:Femur Head / Q000528:radiation effects; D006801:Humans; D008297:Male; D010388:Pelvis / Q000528:radiation effects*; D011467:Prostate / Q000528:radiation effects; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000517:prevention & control; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000009:adverse effects; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects; D012007:Rectum / Q000528:radiation effects; D012669:Seminal Vesicles / Q000528:radiation effects; D001743:Urinary Bladder / Q000528:radiation effects