Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented.
Lahm
George P
GP
DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA. george.p.lahm@usa.dupont.com
Stevenson
Thomas M
TM
Selby
Thomas P
TP
Freudenberger
John H
JH
Cordova
Daniel
D
Flexner
Lindsey
L
Bellin
Cheryl A
CA
Dubas
Christine M
CM
Smith
Ben K
BK
Hughes
Kenneth A
KA
Hollingshaus
J Gary
JG
Clark
Christopher E
CE
Benner
Eric A
EA
D000818:Animals; D002460:Cell Line; D006801:Humans; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007915:Lepidoptera / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D051381:Rats; D019837:Ryanodine Receptor Calcium Release Channel / Q000187:drug effects*; D013329:Structure-Activity Relationship; D023382:Toxicity Tests, Acute; D015854:Up-Regulation / Q000187:drug effects; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D007306:Insecticides; D019837:Ryanodine Receptor Calcium Release Channel; D062367:ortho-Aminobenzoates; C517733:chlorantranilipole