title: [Aneurysmal subarachnoid hemorrhage. Significance and complications].
abstract: Despite substantial improvement in the management of patients with aneurysmal subarachnoid hemorrhage (SAH), including early aneurysm occlusion by endovascular techniques and surgical procedures, a significant percentage of patients with SAH still experience serious sequelae of neurological or cognitive deficits as a result of primary hemorrhage and/or secondary brain damage. Available neuromonitoring methods for early recognition of ischemia include, among others, measurement of brain tissue O(2) partial pressure, brain metabolism with microdialysis and monitoring of regional blood flow. The triple-H therapy (arterial hypertension, hypervolemia and hemodilution) is the treatment of choice of a symptomatic vasospasm and leads to an enduring recession of ischemic symptoms, if initiated early after the onset of a vasospasm-linked ischemic neurological deficit. Further promising therapy approaches are the administration of highly selective ET(A) receptor antagonists and intracisternal administration of vasodilators in depot form. This review summarizes the major neurological and non-neurological complications following aneurysm occlusion. Possible neuromonitoring techniques to improve diagnosis and therapy for treatment of symptomatic vasospasm as well as extracranial complications are discussed.
authors: Campus Virchow-Klinikum, Klinik für Neurochirurgie, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin. asita.sarrafzadeh@charite.de
authors: A S
authors: AS
authors: Sarrafzadeh
authors: U
authors: U
authors: Kaisers
authors: W
authors: W
authors: Boemke
mesh_terms: D013181:Cortical Spreading Depression; D003422:Critical Care; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D006943:Hyperglycemia; D019586:Intracranial Hypertension / Q000209:etiology; D008171:Lung Diseases / Q000209:etiology; D009422:Nervous System Diseases / Q000209:etiology; D019635:Neurosurgical Procedures; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D020301:Vasospasm, Intracranial / Q000209:etiology; D014883:Water-Electrolyte Imbalance / Q000209:etiology