title: A century of leishmaniasis in Alpes-Maritimes, France.
abstract: A century of publications on leishmaniasis in Alpes-Maritimes, in southern France, is here reviewed. Autochtonous human and canine leishmaniasis were first recognised in this département, which lies by the Mediterranean Sea and near the Italian border, in 1918 and 1925, respectively. The parasite responsible for the leishmaniasis, Leishmania infantum, is transmitted by Phlebotomus perniciosus and P. ariasi. The human leishmaniasis is zoonotic, with domestic dogs acting as the main 'reservoir' hosts. In prospective surveys over the last two decades, a mean of 12% of the domestic dogs checked in Alpes-Maritimes have been found seropositive for L. infantum but only about 50% of the seropositive animals showed any clinical signs of infection at the time of the surveys. During the last 30 years, 178 cases of human visceral leishmaniasis have been recorded in the area. Such cases are sporadic and often opportunistic, occurring predominantly in children (29% of the 178 cases) or HIV-positive subjects (31%). Recently, it has been demonstrated that, in Alpes-Maritimes, approximately 20% of those found seropositive in leishmanin skin tests are asymptomatic carriers, with amastigotes in their peripheral blood.
authors: Equipe de Recherche sur les Leishmanioses, Faculté de Médecine, 28, Avenue de Valombrose, 06107 Nice Cédex 2, France. marty.p@chu-nice.fr
authors: P
authors: P
authors: Marty
authors: A
authors: A
authors: Izri
authors: C
authors: C
authors: Ozon
authors: P
authors: P
authors: Haas
authors: E
authors: E
authors: Rosenthal
authors: P
authors: P
authors: Del Giudice
authors: J
authors: J
authors: Godenir
authors: E
authors: E
authors: Coulibaly
authors: M
authors: M
authors: Gari-Toussaint
authors: P
authors: P
authors: Delaunay
authors: B
authors: B
authors: Ferrua
authors: H
authors: H
authors: Haas
authors: F
authors: F
authors: Pratlong
authors: Y
authors: Y
authors: Le Fichoux
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000453:epidemiology / Q000266:history / Q000635:transmission; D002415:Cats; D002648:Child; D004283:Dog Diseases / Q000453:epidemiology* / Q000266:history / Q000635:transmission; D004285:Dogs; D005589:Foxes; D005602:France / Q000453:epidemiology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D018314:Leishmania infantum; D007896:Leishmaniasis / Q000453:epidemiology* / Q000266:history / Q000635:transmission / Q000662:veterinary; D010691:Phlebotomus / Q000145:classification; D015047:Zoonoses