Apple polyphenols influence cholesterol metabolism in healthy subjects with relatively high body mass index.
We performed a randomized double-blind, placebo-controlled study on moderately obese male and female subjects (71 subjects) with a body mass index ranging from 23 to 30 to evaluate the efficacy of 12-week intake of polyphenols extracted from apples and hop bract (600 mg/day). We confirmed that 12-week ingestion of polyphenol-containing capsules significantly decreased total cholesterol and LDL-cholesterol levels. The effects of the apple polyphenol-containing capsules were more marked than those of the hop bract polyphenol-containing capsules. The visceral fat area and the level of adiponectin in the group administered apple polyphenols improved in comparison with the control group. Blood and physical examinations revealed on clinical problems, and no adverse reactions were observed during the ingestion period. These results demonstrate that apple polyphenols regulate fat metabolism in healthy subjects with relatively high body mass index.
Nagasako-Akazome
Yoko
Y
Fundamental Research Laboratory, Asahi Breweries, Ltd., Moriya-shi, Ibaraki, Japan.
Kanda
Tomomasa
T
Ohtake
Yasuyuki
Y
Shimasaki
Hiroyuki
H
Kobayashi
Tetsuyuki
T
D000924:Anticholesteremic Agents / Q000494:pharmacology; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D008297:Male; D027845:Malus / Q000737:chemistry*; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D016896:Treatment Outcome
D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D002784:Cholesterol