title: Episodic dyscontrol: a controlled replication.
abstract: The authors describe previous research in which the syndrome of episodic dyscontrol is delineated and a majority of patients treated successfully with diphenyldantoin (Dilantin). This original research was uncontrolled because of an ethical dilemma: to withhold active treatment for violent outbursts might result in damage to people or property. The present study undertakes a controlled replication of this original research employing sequential analysis in a double blind discontinuation trial such that no patient was denied active treatment any longer than absolutely necessary. Results indicate a clear superiority for Dilantin over placebo when both were added to a psychotherapeutic treatment regimen for violent behavior. Conclusions based on these results are discussed and suggestions for future research offered.
authors: Department of Psychiatry and Neurology, U.S. Lyster Army Hospital, Fort Rucker, Alabama 36360, USA.
authors: B M
authors: BM
authors: Maletzky
authors: J
authors: J
authors: Klotter
mesh_terms: D000328:Adult; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014754:Violence
chemical_list: D010672:Phenytoin