title: Use of the new proliferation signal inhibitor everolimus in renal transplant patients in Spain: preliminary results of the EVERODATA registry.
abstract: Everolimus (Eve) has shown good efficacy and safety profiles in clinical trials in combination with low doses of cyclosporine but there is limited experience in other modes, especially with calcineurin inhibitor elimination. We developed a retrospective study to analyze its clinical use after approval in Europe in 2005. Herein we have presented the results of a series of 272 patients followed for the first 6 months after Eve introduction. In 93.8% of cases Eve was introduced after the first month posttransplantation (conversion use), and 6 months after introduction, the CNI had been eliminated in 75% of cases. The main indication for Eve introduction was the diagnosis of a malignant neoplasm (42%), whereas the combined indication of prevention and/or treatment of toxicity, especially nephrotoxicity, accounted for 46.3% of cases. Initial doses were low (1.37 mg/d), but were progressively increased up to 2 mg/d at 6 months. Renal function remained unchanged during the follow-up period, whereas proteinuria moderately increased. Only 5 cases (2%) of acute rejection episodes were observed with excellent patient and graft survivals at 6 months after conversion. Further analysis of this extensive series of patients with a longer follow-up is needed.
authors: H.U. Marqués de Valdecilla, Santander, Spain. ruizc@humv.es
authors: J C
authors: JC
authors: Ruiz
authors: A
authors: A
authors: Sánchez
authors: M
authors: M
authors: Rengel
authors: I
authors: I
authors: Beneyto
authors: J J
authors: JJ
authors: Plaza
authors: S
authors: S
authors: Zárraga
authors: P
authors: P
authors: Errasti
authors: A
authors: A
authors: Andrés
authors: J M
authors: JM
authors: Morales
authors: J V
authors: JV
authors: Torregrosa
authors: A
authors: A
authors: Alarcón
authors: A
authors: A
authors: Morey
authors: R
authors: R
authors: Romero
authors: A
authors: A
authors: Fernández
authors: J M
authors: JM
authors: Díaz
authors: C
authors: C
authors: Cantarell
mesh_terms: D000328:Adult; D000368:Aged; D065095:Calcineurin Inhibitors; D002455:Cell Division / Q000187:drug effects; D000068338:Everolimus; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D012042:Registries; D012189:Retrospective Studies; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013030:Spain
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D000068338:Everolimus; D020123:Sirolimus