Ictal asystole: a benign condition?
Ictal asystole (IA) has been implicated as a preventable cause of sudden unexplained death in epilepsy presumably provoked by a direct autonomic effect of the electrical stimulus on the heart. An electronic database search of patients with IA was performed comparing heart rate (HR) characteristics to a group of patients with vasovagal asystole. IA was seen in eight patients, all with temporal lobe epilepsy. No statistical difference was found in duration of asystole, bradycardia, and baseline HR characteristics except of a higher HR acceleration postasystole in the controls. None of the six patients with IA who underwent pacemaker implantation had recurrence of asystolic events during mean follow-up of 5 years. This study in a small group of patients suggests that the epileptic activation leading to IA is possibly mediated through a transient increase in vagal tone and not by a direct autonomic effect on the heart.
Schuele
Stephan U
SU
Department of Neurology, Northwestern University, Chicago, IL, USA. s-schuele@northwestern.edu
Bermeo
Adriana C
AC
Locatelli
Eduardo
E
Burgess
Richard C
RC
Lüders
Hans O
HO
D000328:Adult; D001919:Bradycardia / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D015897:Comorbidity; D019992:Databases as Topic / Q000706:statistics & numerical data; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D004562:Electrocardiography / Q000379:methods / Q000706:statistics & numerical data*; D004569:Electroencephalography / Q000706:statistics & numerical data; D004827:Epilepsy / Q000175:diagnosis* / Q000453:epidemiology; D005500:Follow-Up Studies; D006323:Heart Arrest / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011379:Prognosis; D055502:Secondary Prevention; D019462:Syncope, Vasovagal / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control