Copper(II) complexes of salicylaldehyde hydrazones: synthesis, structure, and DNA interaction.
Three hydrazone ligands, H2L1-H2L3, made from salicylaldehyde and ibuprofen- or naproxen-derived hydrazides, were prepared and transformed into the corresponding copper(II) complexes [Cu(II)L1] x H2O, [Cu(II)L2], and [(Cu(II))2(L3)2] x H2O x DMF (Scheme). The X-ray crystal structure of the last-mentioned complex was solved (Fig. 1), showing a square-planar complexation geometry, and the single units were found to form a one-dimensional chain structure (Fig. 2). The interactions of these complexes with CT-DNA were studied by different techniques, indicating that they all bind to DNA by classical and/or non-classical intercalation modes.
Wu
La-Mei
LM
State Key Laboratory of Virology, College of Pharmacy, Wuhan University, Wuhan 430072, PR China.
Teng
Han-Bing
HB
Ke
Xian-Bing
XB
Xu
Wen-Jin
WJ
Su
Jiang-Tao
JT
Liang
Shu-Cai
SC
Hu
Xian-Ming
XM
D000447:Aldehydes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry*; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
C524281:(N'-((2-hydroxyphenyl)methylidene)-2-(6-methoxynaphthalen-2-yl)propanehydrazide)copper(II); C524280:(N1-((2-hydroxyphenyl)methylidene)-2-(4-(2-methylpropyl)phenyl)propanehydrazide)copper(II); D000447:Aldehydes; D006835:Hydrazones; D007364:Intercalating Agents; D009942:Organometallic Compounds; C524282:bis(N'-((2-hydroxyphenyl)methylidene)-2-(6-methoxynaphthalen-2-yl)propanehydrazide)dicopper(II); C013243:salicylaldehyde; D003300:Copper; D004247:DNA