Influential factors of thresholds for electrically evoked potentials elicited by intraorbital electrical stimulation of the optic nerve in rabbit eyes.
Influential factors of electrical thresholds for electrically evoked potentials elicited by intraorbital stimulation of the optic nerve, including stimulation positions of the optic nerve, stimulating electrodes, frequency and duration of electrical pulses and pathological status of the optic nerve, were evaluated in 48 pigmented rabbit eyes. Intravenous injection of sodium iodate was used to induce transneuronal degeneration of the retinal ganglion layer subsequent to photoreceptor death. Two equations were derived to predict electrical thresholds needed to elicit cortical responses.
Wang
Kai
K
People Eye Centre of People's Hospital, Peking University, Xicheng District, Beijing, China.
Li
Xiao-Xin
XX
Jiang
Yan-Rong
YR
Dong
Jian-Qiang
JQ
D000818:Animals; D001766:Blindness / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D004558:Electric Stimulation / Q000379:methods; D004566:Electrodes; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005123:Eye / Q000503:physiopathology; D005654:Fundus Oculi; D020287:In Situ Nick-End Labeling / Q000379:methods; D007275:Injections, Intravenous; D007452:Iodates / Q000008:administration & dosage; D008854:Microscopy, Electron / Q000379:methods; D009900:Optic Nerve / Q000473:pathology / Q000503:physiopathology*; D010857:Pigment Epithelium of Eye / Q000473:pathology; D011817:Rabbits; D012160:Retina / Q000473:pathology; D012684:Sensory Thresholds / Q000502:physiology
D007452:Iodates; C032285:sodium iodate