Quantification of physiological and hemodynamic indices using T(1) dynamic contrast-enhanced MRI in intracranial mass lesions.
OBJECTIVE
To estimate precontrast tissue parameter (T(10)) using fast spin echo (FSE) and to quantify physiological and hemodynamic parameters with leakage correction using T(1)-weighted dynamic contrast-enhanced (DCE) perfusion imaging.


METHODS
Voxel-wise T(10) computation was performed followed by the analysis of T(1)-weighted DCE perfusion data for the conversion of signal intensity time curve to concentration time curve, estimation of hemodynamic and physiological perfusion indices, and a method for leakage correction. Validations of accuracy of the computations have also been carried out.


RESULTS
The computed T(10) and hemodynamic perfusion indices in normal white and gray matter were in good agreement with the literature values. Physiological perfusion indices in these regions were found negligible, validating computations. Cerebral blood volume (CBV) values change negligibly over the length of concentration time curve in white matter, gray matter, and lesion (CBV(corrected)), while CBV(uncorrected) (lesion) shows linear increase over time.


CONCLUSIONS
T(1)-weighted DCE perfusion data along with FSE-based T(1) estimation can be used for an accurate estimation of hemodynamic and physiological perfusion indices.
Singh
Anup
A
Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, India.
Haris
Mohammad
M
Rathore
Divya
D
Purwar
Ankur
A
Sarma
Manoj
M
Bayu
Getaneh
G
Husain
Nuzhat
N
Rathore
Ram K Singh
RK
Gupta
Rakesh K
RK
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology; D002560:Cerebrovascular Circulation; D002648:Child; D003287:Contrast Media / Q000494:pharmacology*; D005910:Glioma / Q000473:pathology; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D010477:Perfusion; D015203:Reproducibility of Results; D013113:Spin Labels; D014375:Tuberculoma / Q000473:pathology
D003287:Contrast Media; D013113:Spin Labels