Spindle cell hemangioma: report of a case presenting in the oral cavity.
BACKGROUND
Spindle cell hemangioma, formerly termed spindle cell hemangioendothelioma, is an uncommon benign vascular tumor. Presentation in the oral cavity is rare with only two previously reported cases.


METHODS
We report a case of spindle cell hemangioma that presented as an asymptomatic mass of the buccal mucosa in a 44-year-old man.


RESULTS
The tumor was a well-circumscribed vascular proliferation of spindled to epithelioid endothelial cells. Tumor cells with intracytoplasmic vascular lumens were present in several areas. Larger, ectatic, thin-walled vessels lined by a single layer of flattened endothelial cells were evident at the periphery and focally in more cellular areas. The tumor was positive for CD31 and CD34.


CONCLUSIONS
Spindle cell hemangioma rarely presents in the oral cavity and needs to be considered in the differential diagnosis of oral cavity vascular tumors to avoid misdiagnosis as a more aggressive vascular tumor.
Sheehan
Michael
M
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA. mpsheeha@iupui.edu
Roumpf
Sheila O
SO
Summerlin
Don-John
DJ
Billings
Steven D
SD
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis; D006391:Hemangioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006394:Hemangiosarcoma / Q000175:diagnosis; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D012514:Sarcoma, Kaposi / Q000175:diagnosis; D016896:Treatment Outcome
D014408:Biomarkers, Tumor