Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease.
To investigate whether fractalkine receptor CX3CR1 polymorphisms that have been associated with rapid progression to AIDS among HIV-1 positive individuals also affects the risk of human T cell lymphotropic virus type 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP), we compared the allele frequencies of V249I and T280M between 233 HAM/TSP patients and 213 HTLV-1 seropositive asymptomatic carriers (HCs). Although the frequency and absolute number of peripheral blood CX3CR1+CD4+T cells were significantly increased in HAM/TSP patients compared to HCs and uninfected controls independent of HTLV-1 trans-activator protein Tax, we could not observe any association between the two polymorphisms and the risk of HAM/TSP in our cohort.
Saito
Mineki
M
Department of Microbiology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Ishikawa 920-0293, Japan. mineki@kanazawa-med.ac.jp
Usuku
Koichiro
K
Arimura
Kimiyoshi
K
Izumo
Shuji
S
Osame
Mitsuhiro
M
Ohara
Yoshiro
Y
D000483:Alleles; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D000073883:CX3C Chemokine Receptor 1; D002353:Carrier State; D015480:Deltaretrovirus Antibodies / Q000032:analysis; D005434:Flow Cytometry; D005838:Genotype; D015658:HIV Infections / Q000235:genetics; D006801:Humans; D018655:Lymphocyte Count; D015493:Paraparesis, Tropical Spastic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D011110:Polymorphism, Genetic / Q000235:genetics; D019707:Receptors, Chemokine / Q000096:biosynthesis* / Q000235:genetics; D013116:Spinal Cord / Q000201:enzymology / Q000473:pathology
D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D015480:Deltaretrovirus Antibodies; D019707:Receptors, Chemokine