title: Right atrial effects on right ventricular ejection fraction derived from thermodilution measurements.
abstract: OBJECTIVE
  The thermodilution technique provides a convenient means to monitor cardiac output, right ventricular (RV) ejection fraction (EF), and volumes at the bedside. To calculate RVEF from the pulmonary artery temperature curve, the bolus thermodilution technique assumes that right atrial (RA) temperature returns to baseline value within 1 beat following the cold saline injection. The authors hypothesized that this assumption is the reason why the thermodilution technique consistently underestimates RVEF.
  
  
  METHODS
  A theoretical analysis and animal study.
  
  
  METHODS
  Laboratory, university, multi-institutional.
  
  
  METHODS
  Animals.
  
  
  METHODS
  Cold saline injections.
  
  
  RESULTS
  In 2 porcine experiments, after a rapid injection of cold saline into right atrium, RA temperature took several heartbeats to return to baseline. In a theoretical analysis, if after the cold saline injection RA temperature returned to baseline in 1 beat (RAEF = 1), then thermodilution-derived RVEF(T) = actual RVEF(A). In contrast, if RA temperature took several beats to return to baseline (RAEF = RVEF), then RVEF(T) consistently underestimated RVEF(A). A least square fit of RVEF(A) versus RVEF(T) resulted in RVEF(A) = 1.0 x RVEF(T) + 0.11. Applying this correction (adding 0.11 to RVEF(T)) to the data gave relatively small errors in estimating RVEF over a wide EF range.
  
  
  CONCLUSIONS
  After injecting cold saline into the right atrium, RA temperature takes several heart beats to return to baseline temperature, leading to underestimating RVEF and overestimating RV volumes. The pulsed thermal energy approach by injecting heat into the RV avoids these problems, but the impact of its small temperature signal on RVEF measurements needs to be determined.
authors: Department of Physiology, Division of Cardiovascular Research, Temple University, Philadelphia, PA 19140, USA. williamsantamore@hotmail.com
authors: William P
authors: WP
authors: Santamore
authors: Nurit
authors: N
authors: Gefen
authors: Aharon
authors: A
authors: Avramovich
authors: Philip
authors: P
authors: Berger
authors: Abul
authors: A
authors: Kashem
authors: Ofer
authors: O
authors: Barnea
mesh_terms: D000465:Algorithms; D000818:Animals; D016280:Atrial Function, Right / Q000502:physiology*; D001831:Body Temperature / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology*; D002407:Catheterization, Swan-Ganz; D012107:Research Design; D012965:Sodium Chloride / Q000008:administration & dosage; D013552:Swine; D013815:Thermodilution / Q000379:methods* / Q000706:statistics & numerical data; D016278:Ventricular Function, Right / Q000502:physiology*
chemical_list: D012965:Sodium Chloride