[Possible role of the FGF23-Klotho axis in bone mineralization].
FGF23 was identified as a causative factor for hypophosphatemic rickets/osteomalacia. The following studies have confirmed its essential role in phosphate and vitamin D metabolism in normal physiology. Recent studies revealed that Klotho, originally identified as an aging-associated molecule, is necessary for the specific action of FGF23. Much attention is now paid to the FGF23-Klotho axis as a novel regulatory system in the mineral metabolism, whereas local action of FGF23 in bone metabolism or bone mineralization remains unresolved.
Shimada
Takashi
T
Kirin Pharma Co., Ltd., Discovery Research Laboratories, Nephrology.
D000818:Animals; D002113:Calcification, Physiologic / Q000502:physiology*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology*; D005966:Glucuronidase / Q000502:physiology*; D000090265:Klotho Proteins; D051379:Mice
C000717428:Fgf23 protein, mouse; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins