Carotid intima-media thickness and stiffness in relation to type 2 diabetes in Chinese.
We investigated carotid intima-media thickness (IMT) and quantitative carotid stiffness (QCS) index in relation to plasma glycosylated hemoglobin A(1C) (HbA(1C)) and duration of diabetes mellitus in 337 Chinese diabetic patients. In categorical analyses, carotid IMT was 710 mum in subjects with a duration of diabetes mellitus < or = 2 years, 760 micorm in subjects with a duration of diabetes mellitus more than two years and with plasma HbA(1C) < 6.5% (P < 0.05), and 790 microm in subjects with a duration of diabetes mellitus more than two years but with plasma HbA(1C) > or = 6.5% (P < 0.01). The corresponding values for QCS values were 4.5, 4.6 and 5.1 (P < 0.05), respectively. In multiple stepwise regression analyses carotid IMT was significantly associated with the duration of diabetes mellitus, systolic blood pressure and serum concentration of total cholesterol, whereas QCS was significantly associated with age, HbA(1C), systolic and diastolic blood pressure (P < 0.05). In conclusion, carotid IMT as a structural measure of arterial wall is increased in patients with a longer history of diabetes mellitus, whereas QCS as functional index is mainly influenced by the quality of blood glucose control.
Liu
Yan-Ping
YP
Department of Ultrasonography, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197 Ruijin 2nd Road, Shanghai 200025, P.R. China.
Zhan
Wei-Wei
WW
Zhang
Yi-Fei
YF
Chen
Yu-Hong
YH
Lin
Yan-Yan
YY
Zhu
Ying
Y
Ren
Xin-Ping
XP
Li
Xiao-Ying
XY
Ning
Guang
G
D000367:Age Factors; D044466:Asian People; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography
D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin