title: Effects of melatonin and rilmazafone on nocturia in the elderly.
abstract: We compared the effects of melatonin, an antioxidant and sleep inducer in humans, and rilmazafone hydrochloride, a hypnotic, in elderly patients with nocturia. Patients received either melatonin (2 mg/day; n = 20) or rilmazafone (2 mg/day; n = 22) for 4 weeks. There were no significant differences in the mean age, the quality of life (QoL) score and the serum melatonin levels between the two groups at baseline. After 4 weeks' treatment, the number of nocturnal urinations was significantly decreased and the QoL score was significantly improved in both groups. There was no significant difference between the patient-reported effectiveness ratings between the two groups. The serum melatonin level was significantly increased in the melatonin-treated group, but it remained unchanged in the rilmazafone-treated group. Melatonin and rilmazafone were equally effective for nocturia in the elderly. We recommend that the problems of sleep disturbance should be considered when choosing a therapy for nocturia.
authors: Division of Urology, Department of Organ-oriented Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan. sugaya@med.u-ryukyu.ac.jp
authors: K
authors: K
authors: Sugaya
authors: S
authors: S
authors: Nishijima
authors: M
authors: M
authors: Miyazato
authors: K
authors: K
authors: Kadekawa
authors: Y
authors: Y
authors: Ogawa
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008550:Melatonin / Q000097:blood / Q000627:therapeutic use*; D053158:Nocturia / Q000188:drug therapy* / Q000503:physiopathology; D011788:Quality of Life; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D006993:Hypnotics and Sedatives; D014230:Triazoles; C041075:rilmazafone; D008550:Melatonin