Electrochemotherapy for the treatment of squamous cell carcinoma in cats: a preliminary report.
Squamous cell carcinomas (SCC) of the skin are commonly described in cats. Reported treatments include surgery, radiation therapy and photodynamic therapy. This preliminary study reports on the management of these lesions combining the local administration of bleomycin (plus hyaluronidase for a more uniform distribution) with permeabilizing biphasic electric pulses. Nine cats with SCC graded T(2)-T(4) were treated over a 5 year period, and each cat received two sessions of electrochemotherapy (ECT) 1 week apart. The side effects of this treatment were minimal and limited to mild erythema of the nose. Seven of the cats (77.7%) had a complete response lasting up to 3 years. ECT seems to be a safe and effective option for the treatment of feline sun-induced squamous cell carcinomas and warrants further investigation.
Spugnini
Enrico P
EP
S.A.F.U. Department, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy. info@enricospugnini.net
Vincenzi
Bruno
B
Citro
Gennaro
G
Tonini
Giuseppe
G
Dotsinsky
Ivan
I
Mudrov
Nikolay
N
Baldi
Alfonso
A
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D002371:Cat Diseases / Q000188:drug therapy* / Q000473:pathology; D002415:Cats; D053672:Electrochemotherapy / Q000379:methods / Q000662:veterinary*; D005260:Female; D008297:Male; D012449:Safety; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D013997:Time Factors; D016896:Treatment Outcome