Metabolic imaging of myocardial triglyceride content: reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers.
Institutional review board approval and informed consent were obtained. The purpose of the study was to prospectively compare spectral resolution and reproducibility of hydrogen 1 (1H) magnetic resonance (MR) spectroscopy, with and without respiratory motion compensation based on navigator echoes, in the assessment of myocardial triglyceride content in the human heart. In 20 volunteers (14 men, six women; mean age+/-standard error, 31 years+/-2.8 [range, 19-60 years]; body mass index, 19-30 kg/m2) without history of cardiovascular disease, 1H MR spectroscopy of the myocardium was performed at rest, with and without respiratory motion compensation. Unsuppressed water signal linewidth changed from 11.9 Hz to 10.7 Hz (P<.001) with the use of the navigator, which indicated better spectral resolution. The navigator improved the intraclass correlation coefficient for the assessment of myocardial triglyceride content from 0.32 to 0.81. Therefore, the authors believe that respiratory motion correction is essential for reproducible assessment of myocardial triglycerides.
van der Meer
Rutger W
RW
Department of Radiology, Leiden University Medical Center, Albinusdreef 2, C2-S, 2333 ZA Leiden, the Netherlands.
Doornbos
Joost
J
Kozerke
Sebastian
S
Schär
Michael
M
Bax
Jeroen J
JJ
Hammer
Sebastiaan
S
Smit
Johannes W A
JW
Romijn
Johannes A
JA
Diamant
Michaela
M
Rijzewijk
Luuk J
LJ
de Roos
Albert
A
Lamb
Hildo J
HJ
D000328:Adult; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009038:Motion; D009206:Myocardium / Q000737:chemistry*; D011446:Prospective Studies; D015203:Reproducibility of Results; D012119:Respiration; D014280:Triglycerides / Q000032:analysis*
D014280:Triglycerides