Positional assignment of differentially substituted bisaminoacylated pdCpAs.
The synthesis and NMR analysis of a 2'-O-alanyl, 3'-O-[1-(13)C]valyl-pdCpA derivative has permitted the definitive assignment of the positions of acylation of tandemly activated pdCpAs, and the bisaminoacylated transfer RNAs derived therefrom.
Maloney
David J
DJ
Department of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.
Ghanem
Noha
N
Zhou
Jia
J
Hecht
Sidney M
SM
D000215:Acylation; D000409:Alanine / Q000737:chemistry*; D014176:Protein Biosynthesis; D012343:RNA, Transfer / Q000138:chemical synthesis*; D014633:Valine / Q000737:chemistry*
D012343:RNA, Transfer; D014633:Valine; D000409:Alanine