Three-dimensional genome organization in interphase and its relation to genome function.
Higher order chromatin structure, i.e. the three-dimensional (3D) organization of the genome in the interphase nucleus, is an important component in the orchestration of gene expression in the mammalian genome. In this review we describe principles of higher order chromatin structure discussing three organizational parameters, i.e. chromatin folding, chromatin compaction and the nuclear position of the chromatin fibre. We argue that principles of 3D genome organization are probabilistic traits, reflected in a considerable cell-to-cell variation in 3D genome structure. It will be essential to understand how such higher order organizational aspects contribute to genome function to unveil global genome regulation.
Goetze
Sandra
S
Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 318, 1098 SM Amsterdam, The Netherlands. goetze@imsb.biol.ethz.ch
Mateos-Langerak
Julio
J
van Driel
Roel
R
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000502:physiology; D002843:Chromatin / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D002875:Chromosomes / Q000235:genetics / Q000502:physiology; D016678:Genome / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D007399:Interphase / Q000235:genetics / Q000502:physiology*; D017510:Protein Folding
D002843:Chromatin