title: Mutagenic activity of river water from a river near textile industrial complex in Korea.
abstract: The mutagenic activity of XAD-2 adsorbates and water extracts recovered from nine locations of the Kumho River was tested on S. typhimurium TA98 strain to identify the source of the mutagenicity. A sampling site, receiving effluents from the textile industrial complex located in Daegu City, showed extraordinarily high mutagenic activity, especially in the presence of S9 mixture, at all sampling time in both XAD-2 adsorbates and dichloromethane extracts. This indicated the existence of the frame-shift mutagens in the Kumho River, same type of mutagens detected in previous studies by other researchers in the Nakdong River into which the Kumho River discharges. The fractionation study showed that the mutagenic chemicals in the river water are mid-polar. Furthermore, mean tail length obtained by single cell gel electrophoresis assay (Comet assay) showed consistent dose-dependent DNA damage, indicating that the chemicals in the river water not only act as frame-shift mutagens but also break human lymphocytes DNA strain. Chemical identification of the mutagens should be required.
authors: Department of Environmental Toxicology (UTOX), Swiss Federal Institute of Aquatic Science and Technology (EAWAG), Uberlandstrasse 133, P.O. Box 611, 8600 Dübendorf, Switzerland. Jung-Hwan.Kwon@eawag.ch
authors: Jung-Hwan
authors: JH
authors: Kwon
authors: Hyun-Kul
authors: HK
authors: Lee
authors: Jin-Wook
authors: JW
authors: Kwon
authors: Kyun
authors: K
authors: Kim
authors: Eunju
authors: E
authors: Park
authors: Myung-Hee
authors: MH
authors: Kang
authors: Yong-Hwa
authors: YH
authors: Kim
mesh_terms: D020552:Comet Assay; D004784:Environmental Monitoring; D006801:Humans; D007220:Industrial Waste; D007723:Korea; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D009153:Mutagens / Q000737:chemistry* / Q000633:toxicity*; D045483:Rivers / Q000737:chemistry*; D013783:Textile Industry; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity*
chemical_list: D007220:Industrial Waste; D009153:Mutagens; D014874:Water Pollutants, Chemical