I/D genetic polymorphism of angiotensin-converting enzyme: pathogenesis evaluation for erectile dysfunction by gene ontology.
OBJECTIVE
Angiotensin-converting enzyme (ACE) is the major regulator of mineralocorticoid synthesis and it is in the renin/angiotensin system. Angiotensin-converting enzyme is responsible for several vascular diseases. It also relates to erectile dysfunction. However, in-depth analysis on the effect of genetic I/D polymorphism of ACE has never been performed. The molecular mechanisms for each genotype expression in erectile dysfunction are poorly understood.


METHODS
Gene ontology technique.


METHODS
Chulalongkorn University Hospital, Bangkok, Thailand.


METHODS
Men with erectile dysfunction.


METHODS
In the present study, I have used a new gene ontology technique to predict the molecular function and biological process for the II, ID, and DD genotypes of ACE.


METHODS
Molecular function and biological process.


RESULTS
According to this gene ontology study, it can be shown that the DD genotype lacks molecular function and biological process.


CONCLUSIONS
The lack of carboxypeptidase activity in DD genotype might be the clue for erectile dysfunction pathogenesis.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address: wviroj@yahoo.com.
D000483:Alleles; D002268:Carboxypeptidases / Q000378:metabolism; D007172:Erectile Dysfunction / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests
D002268:Carboxypeptidases; D007703:Peptidyl-Dipeptidase A