Structural characterization of schintrilactone, a new class of nortriterpenoids from Schisandra chinensis.
Two new nortriterpenoids, designated as schintrilactones A (1) and B (2), with modified five-membered D ring and delta-lactone E ring, were isolated from Schisandra chinensis. Their structures were determined to have a unique carbon skeleton by elucidation of spectroscopic evidence and density functional theory calculations of circular dichroism. Schintrilactones A and B occur as a pair of configurationally unstable and thus slowly interconverting diastereomers.
Huang
Sheng-Xiong
SX
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Yang
Jing
J
Huang
Hao
H
Li
Li-Mei
LM
Xiao
Wei-Lie
WL
Li
Rong-Tao
RT
Sun
Han-Dong
HD
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology
D019380:Anti-HIV Agents; D014315:Triterpenes; C524149:schintrilactone A