title: Silenes in organic synthesis: a concise synthesis of (+/-) -epi-picropodophyllin.
abstract: A concise, seven step synthesis of the aryl tetralin lignan lactone epi-picropodophyllin from piperonal is described. The key steps are a silene diene Diels-Alder reaction and the Hosomi-Sakurai reaction of the resultant silacyclohexene.
authors: Department of Chemistry, University of Durham, Science Laboratories, Durham, UK.
authors: Robert D C
authors: RD
authors: Pullin
authors: Jonathan D
authors: JD
authors: Sellars
authors: Patrick G
authors: PG
authors: Steel
mesh_terms: D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D029751:Silene / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C415032:picropodophyllin; D011034:Podophyllotoxin