The role of hypertriglyceridemia in atherosclerosis.
Atherosclerosis is a chronic disease associated with accumulation of lipids in lesions along blood vessels, leading to the occlusion of blood flow. Much of the focus has been on the role of low-density lipoprotein (LDL), and of oxidatively modified LDL, in the initiation and progression of this disease. LDL is in fact a metabolic end-product of the triglyceride-rich lipoproteins (ie, very-low density lipoproteins). Over the years, univariate analyses have implicated triglycerides as a contributor in atherosclerosis. However, depending on the studies, the significance of this relationship is either reduced or nullified when other co-variates are taken into account. This review summarizes more recent data that support the role of triglyceride-rich lipoproteins in the atherosclerotic process, both in the fasted as well as in the postprandial state.
Le
Ngoc-Anh
NA
Emory Lipid Research Laboratory, Atlanta Veterans' Affairs Medical Center, 1670 Clairemont Road, Room 4A187, Decatur, GA 30033, USA. ale@emory.edu
Walter
Mary F
MF
D050197:Atherosclerosis / Q000209:etiology*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology; D005215:Fasting / Q000502:physiology; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications* / Q000235:genetics / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D012307:Risk Factors
D008074:Lipoproteins