title: Clinical implications of late mitral valve regurgitation appearance in the follow-up of heart transplantation.
abstract: BACKGROUND
  Tricuspid regurgitation is frequently observed after orthotopic heart transplantation (OHT), in association with severe pulmonary hypertension. However, the incidence of left-sided valvular disease has not been addressed.
  
  
  OBJECTIVE
  We analyzed the incidence and prognostic implications of left-sided valve disease in 141 patients after OHT.
  
  
  METHODS
  Echocardiography was performed with every endomyocardial biopsy during the first year after OHT and every 6 months thereafter. Mitral regurgitation (MR) grade II or III was considered significant. Graft vasculopathy was assessed using coronary angiography.
  
  
  RESULTS
  Eight patients (6%) developed significant left-sided valvular disease, namely, MR in 6 (4%) and aortic regurgitation (AR) in 2 (1.4%). The 2 cases with AR were diagnosed the first week after OHT, whereas significant MR was diagnosed at mean follow- up of 34 +/- 6 months. Mean regurgitant orifice and volume were 34 +/- 14 mm2 and 41 +/- 15 mL/beat, respectively. Patients with significant MR had experienced a greater number of acute rejection episodes >or=3A, (1.8 +/- 1.7 vs 0.8 +/- 1.05; P = .02) and were associated with allograft vasculopathy in 83% vs 6% among unaffected patients (P = .0001). Four of 6 patients with significant MR died during follow-up (67%) and 1 of the living patients underwent reparative mitral valve surgery. The probability of survival using Kaplan-Meier curves was significantly lower when patients developed late significant MR (54% vs 76%; P = .0001).
  
  
  CONCLUSIONS
  The incidence of significant left-sided valvular disease after OHT was low. MR was associated with a higher degree of previous acute rejection, of graft vasculopathy, and mortality. The presence of moderate or severe MR of late appearance identified a group of OHT patients with poor outcomes.
authors: Institut Clìnic del Tòrax, Servei de Cardiologia, Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Spain. eroig@clinic.ub.es
authors: E
authors: E
authors: Roig
authors: A
authors: A
authors: Jacobo
authors: M
authors: M
authors: Sitges
authors: I
authors: I
authors: Vallejos
authors: C
authors: C
authors: Paré
authors: F
authors: F
authors: Pons
authors: J
authors: J
authors: Serra
authors: M
authors: M
authors: Azqueta
authors: J L
authors: JL
authors: Pomar
authors: F
authors: F
authors: Pérez-Villa
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation / Q000009:adverse effects*; D006349:Heart Valve Diseases / Q000145:classification / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000453:epidemiology*; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D013997:Time Factors