title: Impact of drug-eluting stents on clinical and angiographic outcomes in dialysis patients.
abstract: BACKGROUND
  It remains unclear whether sirolimus-eluting stents (SES) have an advantage over bare metal stents (BMS) in patients on dialysis.
  
  
  RESULTS
  Percutaneous coronary intervention (PCI) using SES was performed in 54 dialysis patients with 69 lesions. A control group for comparison comprised 54 consecutive dialysis patients with 58 lesions who underwent PCI using BMS. Angiographic and clinical follow-ups were scheduled at 9 months. After the procedure, minimum lumen diameter (MLD) was similar between the 2 groups. At follow-up, the SES group had a higher MLD than the BMS group (1.98+/-0.83 mm vs 1.50+/-0.78 mm, p<0.01). In-stent restenosis rate was lower in lesions treated with SES than in those with BMS (22% vs 40%, p=0.048). However, there was no significant difference between the 2 groups for in-segment restenosis (31% vs 43%, p=0.3). During follow-up, there was no significant difference in the incidence of death, myocardial infarction or target lesion revascularization (TLR) (14% vs 21%, p=0.4) between the SES and BMS groups.
  
  
  CONCLUSIONS
  In this retrospective study, SES, in comparison with BMS, reduced in-stent restenosis in patients on dialysis. However, in-segment restenosis and TLR were not statistically different between lesions treated with SES and those with BMS.
authors: Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
authors: Naoki
authors: N
authors: Ishio
authors: Yoshio
authors: Y
authors: Kobayashi
authors: Hideo
authors: H
authors: Takebayashi
authors: Yoshihiro
authors: Y
authors: Iijima
authors: Junji
authors: J
authors: Kanda
authors: Takashi
authors: T
authors: Nakayama
authors: Nakabumi
authors: N
authors: Kuroda
authors: Joseph
authors: J
authors: De Gregorio
authors: Yukinori
authors: Y
authors: Kouno
authors: Masaru
authors: M
authors: Suzuki
authors: Seiichi
authors: S
authors: Haruta
authors: Issei
authors: I
authors: Komuro
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation / Q000379:methods*; D016022:Case-Control Studies; D017023:Coronary Angiography; D023903:Coronary Restenosis; D003331:Coronary Vessels / Q000503:physiopathology; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D006435:Renal Dialysis; D012189:Retrospective Studies; D020123:Sirolimus / Q000008:administration & dosage; D015607:Stents; D016896:Treatment Outcome; D014661:Vasoconstriction / Q000502:physiology
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus