Comparison of anticonvulsant effects of clorazepate dipotassium and diazepam. Four week anticonvulsant study in Rhesus monkeys.
Clorazepate dipotassium and diazepam were administered daily for the first 5 days of each week to Rhesus monkeys at equimolar doses and challanged once a week with a convulsant dose of pentylenetetrazol. Clorazepate exhibited sustained anticonvulsant activity throughout the second, third, and fourth weeks while diazepam was effective only during the second and third weeks.
Plotnikoff
N P
NP
Department of Pharmacodynamics, Abbott Laboratories, North Chicago, Illinois 60064, USA.
O'Brien
G S
GS
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D003009:Clorazepate Dipotassium / Q000627:therapeutic use*; D003292:Convulsants; D003975:Diazepam / Q000627:therapeutic use*; D008253:Macaca mulatta; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome
D000927:Anticonvulsants; D003292:Convulsants; D003009:Clorazepate Dipotassium; D003975:Diazepam; D010433:Pentylenetetrazole