Increased activation of nuclear factor-kappa B (NF-kappaB) in isolated peritoneal macrophages of patients with endometriosis.
Endometriosis is characterized by pelvic inflammation that shows an increased number of activated peritoneal macrophages and their secreted products such as cytokines, growth factors, and angiogenic factors. Our results show that activation of nuclear factor-kappa B (NF-kappaB), a pro-inflammatory transcription factor, is statistically significantly increased in peritoneal macrophages from patients with endometriosis when compared with controls.
Lousse
Jean-Christophe
JC
Fonds de la Recherche Scientifique, FNRS, Belgium.
Van Langendonckt
Anne
A
González-Ramos
Reinaldo
R
Defrère
Sylvie
S
Renkin
Emmanuelle
E
Donnez
Jacques
J
D000328:Adult; D016022:Case-Control Studies; D002467:Cell Nucleus / Q000737:chemistry; D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000737:chemistry*; D012720:Severity of Illness Index; D051996:Transcription Factor RelA / Q000032:analysis*
D051996:Transcription Factor RelA