title: Contraversive eye deviation during stimulation of the subthalamic region.
abstract: Contraversive eye deviation (CED) is most often observed intraoperatively during subthalamic nucleus implantation for Parkinson's disease and considered to result from wrong electrode positioning. We report on a woman, bilaterally implanted in the subthalamic nucleus for severe Parkinson's disease disclosing long-lasting CED only when the stimulators were activated separately. Clinical examination and eye movements recording in this patient showed that CED occurred when stimulation was applied at the site and at similar intensity used for the best antiparkinsonian effect. These results suggest that the subthalamic area may be involved in orienting movements, either through the subthalamic nucleus itself or the fibers from the Frontal Eye Fields. Interestingly, this report shows that CED may be corrected by bilateral stimulation and that CED may not necessarily implicate electrode repositioning.
authors: Department of Neurophysiology, Université de Rennes 1, CHU de Rennes, France. paul.sauleau@univ-rennes1.fr
authors: Paul
authors: P
authors: Sauleau
authors: Pierre
authors: P
authors: Pollak
authors: Paul
authors: P
authors: Krack
authors: Denis
authors: D
authors: Pélisson
authors: Alain
authors: A
authors: Vighetto
authors: Alim-Louis
authors: AL
authors: Benabid
authors: Caroline
authors: C
authors: Tilikete
mesh_terms: D000328:Adult; D004599:Electric Stimulation Therapy / Q000009:adverse effects*; D004567:Electrodes, Implanted / Q000009:adverse effects; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D015835:Ocular Motility Disorders / Q000209:etiology* / Q000473:pathology; D010300:Parkinson Disease / Q000473:pathology / Q000628:therapy; D020531:Subthalamic Nucleus / Q000503:physiopathology*