title: Bioaccessibility and antioxidant activity stability of phenolic compounds from extra-virgin olive oils during in vitro digestion.
abstract: The impact of an in vitro procedure that mimics the physiochemical changes occurring in gastric and small intestinal digestion on the bioaccessibility and antioxidant activity of phenols from 10 extra-virgin olive oil samples was assessed. Extra-virgin olive oil phenols were totally extracted in the aqueous phase, which reproduces gastric fluids during the digestion procedure. A linear bioaccessibility model, based on tyrosol behavior in model oil samples, was used to estimate the bioaccessibility index (BI%) of extra-virgin olive oil phenols. The BI% varied amongst samples from a maximum of 90% to a minimum of 37%, thus indicating that only a fraction of phenols can be considered bioaccessible. The specific antioxidant activity of olive oil phenols proved to be negatively affected by the digestion procedure. By computing a principal component analysis, it was possible to show that differences in the potential bioactive effect of extra-virgin olive oil samples were related to different phenolic profiles.
authors: Dept. Biotecnologie Agrarie, Università degli Studi di Firenze, via Donizetti, 6 50144 Firenze, Italy. dinnella@unifi.it
authors: Caterina
authors: C
authors: Dinnella
authors: Patrizia
authors: P
authors: Minichino
authors: Anna Maria
authors: AM
authors: D'Andrea
authors: Erminio
authors: E
authors: Monteleone
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D001682:Biological Availability; D004063:Digestion; D004355:Drug Stability; D066298:In Vitro Techniques; D000069463:Olive Oil; D010434:Pepsin A / Q000378:metabolism; D010636:Phenols / Q000032:analysis* / Q000378:metabolism* / Q000493:pharmacokinetics; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives / Q000378:metabolism; D010938:Plant Oils / Q000737:chemistry*; D013552:Swine; D014867:Water
chemical_list: D000975:Antioxidants; D000069463:Olive Oil; D010636:Phenols; D010938:Plant Oils; D014867:Water; C011867:4-hydroxyphenylethanol; D010434:Pepsin A; D010626:Phenylethyl Alcohol