title: Perinatal changes of plasma resistin concentrations in pregnancies with normal and restricted fetal growth.
abstract: BACKGROUND
  The adipocytokine resistin inhibits adipogenesis and induces insulin resistance. Intrauterine growth-restricted (IUGR) neonates have reduced fat mass and changes of endocrine/metabolic mechanisms, predisposing to insulin resistance and metabolic syndrome in adult life.
  
  
  OBJECTIVE
  To investigate plasma resistin concentrations in maternal, fetal and neonatal samples from IUGR and appropriate-for-gestational-age (AGA) pregnancies and correlate them with respective insulin concentrations.
  
  
  METHODS
  Plasma resistin and insulin concentrations were determined in 40 mothers and their 20 IUGR and 20 AGA singleton full-term fetuses and neonates on postnatal day 1 (N1) and day 4 (N4).
  
  
  RESULTS
  No significant differences in resistin concentrations were observed between AGA and IUGR groups. In the AGA group, maternal resistin concentrations were significantly lower compared to fetal, N1 and N4 ones (p = 0.003, p = 0.017 and p = 0.039, respectively). Maternal resistin concentrations positively correlated with fetal ones (r = 0.527, p = 0.02). In the IUGR group, maternal resistin concentrations were significantly lower compared to N1 (p < 0.001) and positively correlated with N4 concentrations (r = 0.626, p = 0.007). In both groups, the effect of gender, mode of delivery, parity and adjusted birth weight (customized centiles) on resistin concentrations was not significant. No correlation between resistin and insulin concentrations was documented.
  
  
  CONCLUSIONS
  Lack of difference in resistin concentrations between IUGR and AGA groups, and lack of correlation between resistin and insulin concentrations as well as customized centiles, possibly suggests that resistin may not be directly involved in the regulation of insulin sensitivity and adipogenesis in the perinatal period. Mode of delivery and parity are not associated with circulating resistin concentrations.
authors: Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece.
authors: Despina D
authors: DD
authors: Briana
authors: Maria
authors: M
authors: Boutsikou
authors: Stavroula
authors: S
authors: Baka
authors: Demetrios
authors: D
authors: Gourgiotis
authors: Antonios
authors: A
authors: Marmarinos
authors: Demetrios
authors: D
authors: Hassiakos
authors: Ariadne
authors: A
authors: Malamitsi-Puchner
mesh_terms: D050156:Adipogenesis / Q000502:physiology; D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D005333:Fetus; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D011247:Pregnancy; D052243:Resistin / Q000097:blood*; D012737:Sex Factors; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging
chemical_list: D007328:Insulin; D052243:Resistin