title: [VDR knockout mice and bone mineralization disorders].
abstract: The calciotropic hormone 1alpha, 25-dihydroxyvitamin D(3) [1alpha, 25 (OH)(2)D(3)] regulates many biological actions such as calcium homeostasis, cell differentiation and proliferations. Most of the biological actions of 1alpha, 25 (OH)(2)D(3) are thought to be mediated by the vitamin D receptor (VDR) , which is a member of a nuclear receptor superfamily acting as a ligand-inducible transcription factor. VDR deficient mice (conventional-VDRKO mice) appear the typical phenotype of vitamin D dependent type II rickets. However, no defect in conventional-VDRKO mice was observed in osteoblast specific-conditional VDRKO mice. Here, we introduce VDR function in bone involving such difference phenotype in these mice.
authors: University of Tokyo, Institute of Molecular and Cellular Biosciences.
authors: Ken-ichi
authors: K
authors: Takeyama
authors: Yoko
authors: Y
authors: Yamamoto
authors: Shigeaki
authors: S
authors: Kato
mesh_terms: D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology*; D002113:Calcification, Physiologic; D051379:Mice; D018345:Mice, Knockout; D018167:Receptors, Calcitriol / Q000235:genetics / Q000502:physiology*
chemical_list: D018167:Receptors, Calcitriol