Natural and synthetic polymers as inhibitors of drug efflux pumps.
Inhibition of efflux pumps is an emerging approach in cancer therapy and drug delivery. Since it has been discovered that polymeric pharmaceutical excipients such as Tweens or Pluronics can inhibit efflux pumps, various other polymers have been investigated regarding their potential efflux pump inhibitory activity. Among them are polysaccharides, polyethylene glycols and derivatives, amphiphilic block copolymers, dendrimers and thiolated polymers. In the current review article, natural and synthetic polymers that are capable of inhibiting efflux pumps as well as their application in cancer therapy and drug delivery are discussed.
Werle
Martin
M
Department of Pharmaceutical Technology, Leopold-Franzens University Innsbruck, Innrain 52, 6020, Innsbruck, Austria. martin.werle@uibk.ac.at
D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents; D011108:Polymers