Hereditary thrombophilic risk factors and venous thromboembolism in Istanbul, Turkey: the role in different clinical manifestations of venous thromboembolism.
The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (VTE) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G1691A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients (P = .003 and P = .02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT (P = .04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency.
Okumus
Gulfer
G
Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Capa-Istanbul, Turkey. gulferokumus@yahoo.com
Kiyan
Esen
E
Arseven
Orhan
O
Tabak
Levent
L
Diz-Kucukkaya
Reyhan
R
Unlucerci
Yesim
Y
Abaci
Neslihan
N
Unaltuna
Nihan Erginel
NE
Issever
Halim
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D005165:Factor V / Q000235:genetics; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011486:Protein C / Q000378:metabolism; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D019851:Thrombophilia / Q000209:etiology* / Q000235:genetics; D054556:Venous Thromboembolism / Q000209:etiology*
D011486:Protein C; C095381:factor V Leiden; D006710:Homocysteine; D005165:Factor V; D011516:Prothrombin