title: Cryptadines A and B, novel C27N3-type pentacyclic alkaloids from Lycopodium cryptomerinum.
abstract: Two novel C(27)N(3)-type Lycopodium alkaloids, cryptadines A (1) and B (2) consisting of two octahydroquinoline rings (C(11)N) and a piperidine ring (C(5)N), have been isolated from the club moss Lycopodium cryptomerinum, and their structures and relative stereochemistry were elucidated on the basis of spectroscopic data, chemical transformations, and computational methods. Cryptadines A (1) and B (2) exhibited an inhibitory activity against acetylcholinesterase.
authors: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
authors: Koichiro
authors: K
authors: Koyama
authors: Yusuke
authors: Y
authors: Hirasawa
authors: Jun'ichi
authors: J
authors: Kobayashi
authors: Hiroshi
authors: H
authors: Morita
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D003198:Computer Simulation; D003500:Cyclization; D032502:Lycopodium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification; D011804:Quinolines / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D010880:Piperidines; D011804:Quinolines; C526499:cryptadine A; C526498:cryptadine B