Synthesis and evaluation of hydroquinone derivatives as inhibitors of isocitrate lyase.
Isocitrate lyase (ICL) is envisaged as an attractive drug target for the development of antimicrobial agents. We have prepared a series of hydroquinone derivatives on the basis of the structure of halisulfates, a naturally occurring inhibitor of ICL. The obtained derivatives were evaluated against ICL of C. albicans. The preliminary structure-activity relationships and the minimal structural requirements for potency were established through structural modifications.
Yang
Hyeong-Cheol
HC
Department of Dental Biomaterials Science, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
Yu
Jisu
J
Oh
Ki-Bong
KB
Shin
Dong-Sun
DS
Cho
Won-Jea
WJ
Shin
Jongheon
J
Kim
Sanghee
S
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006873:Hydroquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors*
D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D006873:Hydroquinones; D007522:Isocitrate Lyase; C031927:hydroquinone