title: A pigmented calcifying cystic odontogenic tumor associated with compound odontoma: a case report and review of literature.
abstract: BACKGROUND
  Pigmented intraosseous odontogenic lesions are rare with only 47 reported cases in the English literature. Among them, pigmented calcifying cystic odontogenic tumor, formerly known as calcifying odontogenic cyst, is the most common lesion with 20 reported cases.
  
  
  METHODS
  A case of pigmented calcifying cystic odontogenic tumor associated with odontoma occurring at the mandibular canine-premolar region of a young Japanese boy is presented with radiographic, and histological findings. Special staining, electron microscopic study and immunohistochemical staining were also done to characterize the pigmentation.
  
  
  RESULTS
  The pigments in the lesion were confirmed to be melanin by Masson-Fontana staining and by transmission electron microscopy. The presence of dendritic melanocytes within the lesion was also demonstrated by S-100 immunostaining.
  
  
  CONCLUSIONS
  The present case report of pigmented calcifying cystic odontogenic tumor associated with odontoma features a comprehensive study on melanin and melanocytes, including histochemical, immunohistochemical and transmission electron microscopic findings.
authors: Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan. phuupwinthan@gmail.com
authors: Phuu P
authors: PP
authors: Han
authors: Hitoshi
authors: H
authors: Nagatsuka
authors: Chong H
authors: CH
authors: Siar
authors: Hidetsugu
authors: H
authors: Tsujigiwa
authors: Mehmet
authors: M
authors: Gunduz
authors: Ryo
authors: R
authors: Tamamura
authors: Silvia S
authors: SS
authors: Borkosky
authors: Naoki
authors: N
authors: Katase
authors: Noriyuki
authors: N
authors: Nagai
mesh_terms: D000293:Adolescent; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology*; D008543:Melanins / Q000032:analysis; D046529:Microscopy, Electron, Transmission; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D018333:Odontogenic Cyst, Calcifying / Q000473:pathology*; D009810:Odontoma / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis
chemical_list: D008543:Melanins; D009418:S100 Proteins