title: p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas.
abstract: OBJECTIVE
  To investigate p63 expression in ovarian neoplasms.
  
  
  RESULTS
  Immunohistochemistry using an antibody that detects all p63 isoforms was performed on 103 primary ovarian neoplasms of different histological types. Diffuse nuclear immunoreactivity of p63 was demonstrated in the 17 benign and five borderline Brenner tumours. Only one of the six malignant Brenner tumours displayed p63 expression. p63 immunoreactivity was absent in all the ovarian transitional cell carcinomas (TCC), but was demonstrated extensively in TCCs of the urinary bladder. Besides focal p63 expression in epidermal basal cells of immature and mature teratomas, all other ovarian lesions were devoid of p63 expression. p63 expression was also demonstrated in cervical transitional cell metaplasia and Walthard cell nests of fallopian tubes.
  
  
  CONCLUSIONS
  Expression of p63 protein is apparently cell lineage specific and in ovarian neoplasms is confined to benign and borderline Brenner tumours. The loss of expression in malignant Benner tumours suggests a role for p63 in Brenner carcinogenesis. The distinct patterns of p63 expression in TCCs in the ovary and urinary bladder may help in their differential diagnosis.
authors: Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong.
authors: X Y
authors: XY
authors: Liao
authors: W C
authors: WC
authors: Xue
authors: D H
authors: DH
authors: Shen
authors: H Y S
authors: HY
authors: Ngan
authors: M K
authors: MK
authors: Siu
authors: A N
authors: AN
authors: Cheung
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001948:Brenner Tumor / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C081876:CKAP4 protein, human; D008565:Membrane Proteins