Comparison of extraction techniques for spray dried dispersion tablet formulations.
Non-traditional sample preparation/extraction techniques that utilized the Caliper Life Sciences Tablet Processing Workstation II (TPW II), Microwave Assisted Extraction (MAE), and Accelerated Solvent Extraction (ASE) were evaluated for the extraction of Compound A from a 50 mgA, 15% Spray Dried Dispersion (SDD) immediate released (IR) tablet formulation. The TPW II consistently provided complete recoveries with very short preparation/extraction times (approximately 30 min). MAE also provided complete recovery of the API from the tablet formulation, but required approximately twice the extraction time, while ASE provided the lowest recovery of the three non-traditional techniques. The sample preparation/extraction efficiencies of the three non-traditional techniques were compared to that of the 5.5 h long manual method.
Lee
Carlos
C
Analytical Research and Development, Pfizer Global Research and Development, Eastern Pt. Road, Groton, CT 06340, USA. Carlos.W.Lee@Pfizer.com
Gallo
Jenny
J
Arikpo
William
W
Bobin
Vincent
V
D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D005612:Freeze Drying; D008872:Microwaves; D052616:Solid Phase Extraction; D012997:Solvents / Q000737:chemistry; D013607:Tablets; D013997:Time Factors; D044366:Transition Temperature
D012997:Solvents; D013607:Tablets