title: Marked response to a cisplatin/docetaxel/temozolomide combination in a heavily pretreated patient with metastatic large cell neuroendocrine lung carcinoma.
abstract: At present, there is no clear consensus on the most appropriate treatment approach for large cell neuroendocrine carcinoma of the lung. Large cell neuroendocrine carcinoma lesions differ from other nonsmall cell lung carcinomas in that they have a particularly aggressive clinical behaviour and extremely poor prognosis. We report a 52-year-old woman large cell neuroendocrine carcinoma patient with progressive stage IV disease in the chest, liver, adrenal glands and, particularly, the brain, who achieved a marked response to a fourth-line combination of docetaxel, cisplatin and temozolomide. This regimen significantly improved her quality of life and survival. The good response obtained in this heavily pretreated patient adds to the evidence regarding the use of temozolomide in patients with lung cancer with brain metastases.
authors: Department of Oncology, Derriford Hospital, Plymouth, UK. johngounaris@hotmail.com
authors: Ioannis
authors: I
authors: Gounaris
authors: Joe
authors: J
authors: Rahamim
authors: Siva
authors: S
authors: Shivasankar
authors: Sarah
authors: S
authors: Earl
authors: Bruce
authors: B
authors: Lyons
authors: Dennis
authors: D
authors: Yiannakis
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D018287:Carcinoma, Large Cell / Q000188:drug therapy* / Q000556:secondary; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy* / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077143:Docetaxel; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D011788:Quality of Life; D043823:Taxoids / Q000008:administration & dosage; D000077204:Temozolomide
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D003606:Dacarbazine; D002945:Cisplatin; D000077204:Temozolomide