title: Impact of donor age and recipient status on left-lobe graft for living donor adult liver transplantation.
abstract: Donor safety is the priority when performing a living donor adult liver transplantation (LDALT). We herein present our findings using left-lobe graft in LDALT. Data on 119 recipients who underwent the LDALT, and on 119 donors who underwent extended left lobectomy were reviewed. The recipients were divided into groups above (n = 19) and below (n = 100) 50 years of donor age, into groups above (n = 63) and below (n = 56) 40% of graft size (graft volume/standard liver volume, GV/SLV), and above (n = 25) and below (n = 94) 20 of pre-operative model for end-stage liver disease (MELD). Total bilirubin (TB), volume of ascites, prothrombin time international normalized ratio on postoperative day 14 or survival rates were compared. TB (mg/dl) or volume of ascites (ml) of the group in donor age < 50 years was better than that of the group in donor age > or = 50 years (7.4 vs. 14.7 or 788 vs. 1379, P < 0.001 or P < 0.005, respectively). The graft and patient survival rates of the lower MELD group tended to be better than that of the higher MELD group. LDALT can be safely performed using a left-lobe graft. However, when using the graft from the donor > or = 50 years, especially for the recipients with the MELD > or = 20, the indications should be carefully discussed.
authors: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Tomoharu
authors: T
authors: Yoshizumi
authors: Akinobu
authors: A
authors: Taketomi
authors: Yuji
authors: Y
authors: Soejima
authors: Hideaki
authors: H
authors: Uchiyama
authors: Toru
authors: T
authors: Ikegami
authors: Noboru
authors: N
authors: Harada
authors: Hiroto
authors: H
authors: Kayashima
authors: Yo-Ichi
authors: Y
authors: Yamashita
authors: Mitsuo
authors: M
authors: Shimada
authors: Yoshihiko
authors: Y
authors: Maehara
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005234:Fatty Liver / Q000150:complications / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D017093:Liver Failure / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009929:Organ Size / Q000502:physiology*; D018579:Patient Selection; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome