title: Poly(ethylene oxide) based copolymers: solubilisation capacity and gelation.
abstract: It is thought that almost half of potentially useful drug candidates fail to progress to formulation development because of their low aqueous solubility and associated poor or erratic absorption characteristics. A response to this challenge has been the development of a variety of colloidal delivery systems in which the therapeutic agent is encapsulated in nanosized particles. In this review, attention is focussed on colloidal vectors based on amphiphilic block copolymers, the micelles of which can accommodate a wide range of water-insoluble guest molecules, and particularly on copolymers with poly(oxyethylene) as the hydrophilic block and with poly(oxyalkylene) or polyester hydrophobic blocks, taking advantage of the 'stealth' properties of the poly(oxyethylene) corona of their micelles. Although copolymers of this type have been commercially available for several decades in the form of the Pluronic (BASF) polyols, which have a poly(oxypropylene) hydrophobic block, they have not found wide application for drug solubilisation, primarily because of their low solubilisation capacity. In attempts to achieve greater drug loading, recent work has concentrated on copolymers in which the core-forming blocks are designed to be more hydrophobic and more compatible with the drug to be encapsulated. Progress in this area has been reviewed and recent developments in the design of block copolymers of this type that combine high drug loading capacity with thermally reversible gelation characteristics in the temperature range suitable for potential application as in situ gelling vehicles following subcutaneous injection have also been discussed.
authors: University of Manchester, School of Pharmacy and Pharmaceutical Sciences, Manchester M13 9PL, UK. david.attwood@manchester.ac.uk
authors: David
authors: D
authors: Attwood
authors: Zhengyuan
authors: Z
authors: Zhou
authors: Colin
authors: C
authors: Booth
mesh_terms: D002626:Chemistry, Pharmaceutical; D003102:Colloids / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D005782:Gels / Q000737:chemistry; D006801:Humans; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013696:Temperature
chemical_list: D003102:Colloids; D004337:Drug Carriers; D005782:Gels; D008823:Micelles; D011108:Polymers; D011092:Polyethylene Glycols