Interfrontal commissural abnormality in schizophrenia: tractography-assisted callosal parcellation.
Previous studies have indicated abnormal fiber connectivity of the corpus callosum (CC) in schizophrenia. This study investigated whether the interfrontal commissural region of the CC is decreased in schizophrenia, by partitioning the CC using a function-anatomically relevant internal landmark derived from tractographic analysis of diffusion tensor imaging (DTI). T1 weighted and DTI images were acquired by 3T-MRI. Using tractography, the interfrontal commissural region (anterior part) was partitioned from the rest of the CC in 40 schizophrenia patients and 36 healthy controls. Schizophrenia patients showed smaller anterior/total CC length and area rates. These results suggested interfrontal hypoconnectivity in schizophrenia.
Miyata
Jun
J
Department of Neuropsychiatry, Graduate School of Medicine, Kyoto University, Shogoin-Kawaharacho 54, Kyoto 606-8507, Japan. miyata10@kuhp.kyoto-u.ac.jp
Hirao
Kazuyuki
K
Namiki
Chihiro
C
Fukuyama
Hidenao
H
Okada
Tsutomu
T
Miki
Yukio
Y
Hayashi
Takuji
T
Murai
Toshiya
T
D000328:Adult; D061085:Agenesis of Corpus Callosum; D003337:Corpus Callosum / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D010296:Parietal Lobe / Q000002:abnormalities / Q000473:pathology; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis*