Transcriptional activator TonE-binding protein in cellular protection and differentiation.
The TonE-binding protein (TonEBP) is a transcriptional activator in the Rel family that includes NFkappaB and NFAT. TonEBP is critical for the development and function of the renal medulla, which is a major regulator of water homeostasis. TonEBP is also implicated in diabetic nephropathy and inflammation. Established methods for biochemical and histochemical detection and functional analysis of TonEBP, including identification of novel TonEBP target genes, are described for those who are interested in investigating function and regulation of TonEBP.
Kim
Jeong Ah
JA
Department of Medicine, University of Maryland, Baltimore, Maryland, USA.
Jeon
Un Sil
US
Kwon
Min Seong
MS
Lim
Sun Woo
SW
Kwon
H Moo
HM
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D024202:Electrophoretic Mobility Shift Assay; D006801:Humans; D006982:Hypertonic Solutions / Q000494:pharmacology; D007679:Kidney Medulla / Q000502:physiology; D008969:Molecular Sequence Data; D050778:NFATC Transcription Factors / Q000032:analysis / Q000276:immunology / Q000502:physiology*; D034622:RNA Interference
D006982:Hypertonic Solutions; D050778:NFATC Transcription Factors