Efficacy of n-3 polyunsaturated fatty acids according to clinical characteristics of patients with recent myocardial infarction: insights from the GISSI-Prevenzione trial.
The GISSI-Prevenzione trial established the efficacy of n-3 polyunsaturated fatty acids (PUFAs) for reducing mortality in patients after recent myocardial infarction. The generalisability of such results to clinical practice could vary according to other individual patient characteristics. We analysed the GISSI-Prevenzione database to assess whether other major risk factors, comorbidities, dietary habits, or medications could interact with the efficacy of n-3 PUFA treatment to reduce total mortality. We found no evidence that concomitant disease states, habits, or interventions altered the therapeutic benefit of n-3 PUFA consumption in survivors of recent myocardial infarction.
Marchioli
Roberto
R
Consorzio Mario Negri Sud, Santa Maria Imbaro (CH), Italy. marchioli@negrisud.it
Marfisi
Rosa Maria
RM
Borrelli
Giovanna
G
Chieffo
Carmelo
C
Franzosi
Maria Grazia
MG
Levantesi
Giacomo
G
Maggioni
Aldo Pietro
AP
Nicolosi
Gian Luigi
GL
Scarano
Marco
M
Silletta
Maria Giuseppina
MG
Schweiger
Carlo
C
Tavazzi
Luigi
L
Tognoni
Gianni
G
D003920:Diabetes Mellitus / Q000453:epidemiology; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D009203:Myocardial Infarction / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D055502:Secondary Prevention; D013318:Stroke Volume; D018879:Ventricular Premature Complexes / Q000453:epidemiology; D014810:Vitamin E / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
D015525:Fatty Acids, Omega-3; D014815:Vitamins; D014810:Vitamin E