Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans.
Microbial transformation of adrenosterone (1) by suspended-cell cultures of the filamentous fungus Cunninghamella elegans resulted in the production of five metabolites 2-6, which were identified as 9alpha-hydroxyadrenosterone (2), 11-ketotestosterone (3), 6beta-hydroxyadrenosterone (4), 9alpha-hydroxy-11-ketotestosterone (5), and 6beta-hydroxy-11-ketotestosterone (6). Structures of new metabolites 2, 5, and 6 were established by single-crystal X-ray diffraction analysis.
Choudhary
Muhammad Iqbal
MI
HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. hej@cyber.net.pk
Khan
Naik T
NT
Musharraf
Syed G
SG
Anjum
Shazia
S
Atta-Ur-Rahman
D000736:Androstenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D001711:Biotransformation; D018360:Crystallography, X-Ray; D020093:Cunninghamella / Q000378:metabolism*; D013058:Mass Spectrometry; D008968:Molecular Conformation
D000736:Androstenes; C011657:adrenosterone