title: Lacrimal sac melanoma.
abstract: A 48-year-old woman presented with a 5-month history of unilateral epiphora and progressive growth of a left-sided medial canthus mass. CT revealed a nonenhancing soft tissue mass of the left lacrimal sac with widening and erosion of the nasolacrimal canal. The tumor was resected and pathologically confirmed to be malignant melanoma. Despite wide resection and adjuvant radiotherapy, the patient developed metastases to the chest wall. The patient currently is receiving combined immunotherapy and chemotherapy. The clinical course and treatment strategies are reviewed for this highly aggressive and rare neoplasm.
authors: Department of Ophthalmology, Loyola University Medical Center, Maywood, Illinois, USA.
authors: Sumit
authors: S
authors: Sitole
authors: Chad A
authors: CA
authors: Zender
authors: Amjad Z
authors: AZ
authors: Ahmad
authors: Rasheed
authors: R
authors: Hammadeh
authors: Guy J
authors: GJ
authors: Petruzzelli
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005134:Eye Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D049268:Positron-Emission Tomography; D018714:Radiotherapy, Adjuvant
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins