Effect of repeated induced airway collapse during total liquid ventilation.
Negative pressure generated during the expiratory phase of total liquid ventilation (TLV) may induce airway collapse. Evaluation of the effect of repeated airway collapse is crucial to optimize this technique. A total of 24 New Zealand White rabbits were randomly divided into four groups. Ventilation was performed for 6 hours with different strategies: conventional gas ventilation, TLV without airway collapse, and TLV with collapse induced in either 75 or 150 sequential breaths. In the treated groups, airway collapse was induced by increasing the perfluorocarbon drainage velocity while maintaining the minute ventilation constant. Airway pressure, gas exchange, and blood pressure were monitored at 30-minute intervals. At the end of the experiment, airway and lung parenchyma specimens were processed for light microscopy. No evidence of fluorothorax was noticed in any of the four groups at autopsy examination. Minimal signs of inflammation were noticed in all airway and lung parenchyma specimens, but no evident structural alteration was visible. Adequate gas exchange and systemic blood pressure were maintained during all the studies. Repeated airway collapse is not associated with structural changes in the respiratory system and does not alter the gas exchange ability of the lungs.
Bagnoli
Paola
P
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Tredici
Stefano
S
Seetharamaiah
Rupa
R
Brant
David O
DO
Hewell
Lauren A
LA
Johnson
Kent
K
Bull
Joseph L
JL
Costantino
Maria Laura
ML
Hirschl
Ronald B
RB
D000818:Animals; D001794:Blood Pressure; D005466:Fluorocarbons / Q000627:therapeutic use*; D021061:Liquid Ventilation / Q000379:methods*; D001261:Pulmonary Atelectasis / Q000473:pathology* / Q000628:therapy*; D011659:Pulmonary Gas Exchange; D011817:Rabbits; D011897:Random Allocation; D012129:Respiratory Function Tests
D005466:Fluorocarbons