[Studies on the GS impregnated calcium sulfate implants].
The gentamicin sulfate carried calcium sulfate (GSCS) implants were fabricated by the coagulating method, and the release rate of the gentamicin tested by UV-spectrometer and the absorbing rate of the calcium sulfate carrier in vitro were studied. The release patterns of two types of GSCS were compared. The trend of daily weight loss of GSCS was found being similar to that of pure calcium sulfate, which suggested that the gentamicin part has little effect on the absorbing pattern of calcium sulfate. The release rate of gentamicin is controlled by the erosion rate of calcium sulfate, so GSCS with different amount of gentamicin has the same release patterns. The DRP value of ED is higher than that of CO during the early stage, while the DRP value of ED is lower than that of CO during the late stage. The GSCS samples were implanted into the defect mold on the radii of the rabbits to investigate the potential for the use of GSCS implants as bone fillers, and the results revealed that new bone had been induced in a great part of the defect at 14 weeks after operation.
Wang
Xiaodong
X
School of Science, Tianjin University, Tianjin 300072, China. wangxiaodong@tju.edu.cn
You
Xiudong
X
Huo
Shujuan
S
Li
Xiulan
X
Fan
Yuqiang
Y
Zhang
Yang
Y
Zhang
Wenhai
W
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001861:Bone Regeneration / Q000187:drug effects*; D002133:Calcium Sulfate / Q000008:administration & dosage*; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D020007:Implants, Experimental; D011817:Rabbits; D011885:Radius Fractures / Q000628:therapy*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002133:Calcium Sulfate