[Studies on taste-masking technology of traditional Chinese medicine compounds].
OBJECTIVE
To investigate the preparation of Shuanghuanglian taste-masking microspheres by spray-drying.


METHODS
Traced the compounds bitterness source, marked its curve and optimized the microspheres preparation by taking taste evaluation, microspheres yield and inclusion rate as the indexes.


RESULTS
The bitter taste of compounds comes from Forsythia suspensa. The best taste-masking material is Eudragit E100. The optimal spray-drying parameters: solvent concentration 2.0%, inlet air temperature 75 degrees C, aspirator 35.0 m3 x h(-1), spray flow 0.35 m3 x h(-1), pump speed 8.0 mL x min(-1).


CONCLUSIONS
The spray-drying as a method of masking the traditional Chinese medicine compound taste have advantages of simple process and efficient masking.
Wang
You-jie
YJ
(Shanghai University of Traditional Chinase Madicine, Shanghai 201203, China.
Feng
Yi
Y
Xu
De-sheng
DS
D000179:Acrylates / Q000737:chemistry*; D003890:Desiccation; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D031657:Forsythia / Q000737:chemistry; D008863:Microspheres; D029592:Oleaceae / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013649:Taste; D013678:Technology, Pharmaceutical / Q000379:methods*
D000179:Acrylates; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C477020:Eudragit E100; D011108:Polymers