title: Determining acute health hazard ratings in the absence of applicable toxicological data.
abstract: Health, safety, and emergency planning professionals have a responsibility to identify acute hazards associated with chemicals and to find a way to transmit that information to chemical users, emergency responders, and others. Various organizations such as the Department of Energy are considering acute health hazard ratings as triggers that would mandate various activities. A paradigm shift away from a "lists" based approach to determining whether a chemical is sufficiently hazardous to require further analysis for emergency planning purposes is under way. Various toxicological data sources and approaches in use to develop an acute health hazard rating are discussed. Methods of extrapolating data from published and unpublished supporting documentation to develop an acute health hazard rating in the absence of toxicological data by animal species, chemical structure similarities, MSDS estimated values, and data mining are discussed. The process described analyzes applicable data and allows the analyst to determine reasonable health hazard rating numbers for chemicals without published hazard ratings and for mixtures of chemicals. The level and amount of resources available will determine which methods will be used in the process.
authors: Westinghouse Savannah River Co., Aiken, South Carolina, USA.
authors: Fred
authors: F
authors: Simmons
authors: David
authors: D
authors: Quigley
authors: Dave
authors: D
authors: Freshwater
authors: Helena
authors: H
authors: Whyte
authors: Lydia
authors: L
authors: Boada-Clista
authors: J C
authors: JC
authors: Laul
mesh_terms: D000208:Acute Disease; D000818:Animals; D004189:Disaster Planning / Q000379:methods / Q000592:standards*; D004630:Emergencies; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D004782:Environmental Health; D015386:Hazardous Substances / Q000032:analysis* / Q000145:classification / Q000633:toxicity; D006801:Humans; D018570:Risk Assessment; D017751:Safety Management; D018675:Toxicity Tests; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D015386:Hazardous Substances