title: No association of the -105 promoter polymorphism of the selenoprotein S encoding gene SEPS1 with cerebrovascular disease.
abstract: A common pro-inflammatory promoter variant of the selenoprotein S encoding gene (SEPS1) was studied in young stroke patients from Italy and Germany and in healthy control subjects. The -105A-allele was found in 56 of 205 (27.3%) patients with ischemic stroke IS because of a spontaneous cervical artery dissection (CAD), and in 69 of 295 (23.4%) patients <50 years with IS of non-CAD origin. The SEPS -105A promoter variant was detected in 87 of 393 healthy control subjects (22.1%) and in 11 of 55 CAD patients without IS (20%). The non-significant differences of SEPS1 allele frequencies between disease groups and healthy controls suggest that the SEPS1 -105A allele is not a major-risk factor for stroke.
authors: Department of Neurology, University of Heidelberg, Germany.
authors: S
authors: S
authors: Hyrenbach
authors: A
authors: A
authors: Pezzini
authors: E
authors: E
authors: del Zotto
authors: A
authors: A
authors: Giossi
authors: C
authors: C
authors: Lichy
authors: M
authors: M
authors: Kloss
authors: I
authors: I
authors: Werner
authors: A
authors: A
authors: Padovani
authors: T
authors: T
authors: Brandt
authors: C
authors: C
authors: Grond-Ginsbach
mesh_terms: D000328:Adult; D000483:Alleles; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D051140:Selenoproteins / Q000235:genetics*
chemical_list: D008565:Membrane Proteins; C487710:SELENOS protein, human; D051140:Selenoproteins