title: Hypotonic and hyporesponsive episodes after diptheria-tetanus-acellular pertussis vaccination.
abstract: Administration of the discontinued diphtheria-pertussis-tetanus vaccine was occasionally associated with a hypotonic-hyporesponsive episode in infants. The whole bacterial cell pertussis component was the likely culprit. For this reason, an acellular pertussis component was developed and incorporated into a new vaccine commonly called diptheria-tetanus-acellular pertussis (DTaP). Administration of DTaP vaccine has been followed by remarkably few hypotonic or hyporesponsive episodes. This report describes one of these unusual events.
authors: David Geffen School of Medicine, Mattel Children's Hospital at UCLA, Los Angeles, CA, USA.
authors: James D
authors: JD
authors: Cherry
authors: Albert G
authors: AG
authors: Karam
mesh_terms: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007022:Hypotension; D007223:Infant
chemical_list: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines