title: Chronic idiopathic granulomatous mastitis.
abstract: We describe four women with idiopathic granulomatous mastitis, a rare benign disease. Age range was 32-40 years. Disease duration was less than 1 year in three patients and long term in the fourth. The diagnosis was based on histological findings, after extensive workup ruled out malignancy and known causes of granulomatous mastitis. Treatment with prednisone with gradual tapering yielded a good response. Clinicians should consider the possibility of idiopathic granulomatous mastitis in young women with inflammatory breast processes and negative findings on relevant biopsy, laboratory, and imaging studies. Glucocorticoids are the treatment of choice; surgery is not recommended. Some patients require a glucocorticoid-sparing drug.
authors: Department of Internal Medicine B, Sheba Medical Center, Tel-Hashomer, Israel.
authors: Uriel
authors: U
authors: Katz
authors: Yair
authors: Y
authors: Molad
authors: Jacob
authors: J
authors: Ablin
authors: Debby
authors: D
authors: Ben-David
authors: Daphna
authors: D
authors: Paran
authors: Mordechai
authors: M
authors: Gutman
authors: Pnina
authors: P
authors: Langevitz
mesh_terms: D000038:Abscess / Q000473:pathology; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D006099:Granuloma / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008413:Mastitis / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D008727:Methotrexate / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D011241:Prednisone; D008727:Methotrexate