An estimation method of the half-life for a one-compartment model of a single bolus intravenous injection by a single sampling.
In clinical trials, sometimes only a single drug concentration can be measured from a patient because of the patient's burden. In this case, the sampling point is usually identical for all patients. From a single concentration, we cannot generally obtain point-estimates of each pharmacokinetic parameter. In this paper, we propose a method to estimate the half-life of a one-compartment model of a single bolus intravenous injection from a single concentration at a sampling point of or after three half-lives. We analytically show that the later the sampling point is the better estimate of the half-life we can get. This approach is illustrated by simulated concentration-data and nicorandil concentration-data. Therefore, we compared the performance of the proposed method with that of the Bayesian approach.
Funatogawa
Takashi
T
Biometrics Department, Chugai Clinical Research Center Co., Ltd., Tokyo, Japan. funatogawatks@chugai-pharm.co.jp
Funatogawa
Ikuko
I
Yafune
Akifumi
A
D000465:Algorithms; D000959:Antihypertensive Agents / Q000097:blood / Q000493:pharmacokinetics; D001499:Bayes Theorem; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D015233:Models, Statistical; D020108:Nicorandil / Q000097:blood / Q000493:pharmacokinetics; D010599:Pharmacokinetics
D000959:Antihypertensive Agents; D020108:Nicorandil