title: Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator.
abstract: In the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78 expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The planar structure of prunustatin A was determined to be an oxidized type of the neoantimycin family. Its absolute stereochemistry was established to be 2R, 4S, 6S, 7R, 9S, and 29S by analyzing chemically degraded components obtained from the derivative of prunustatin A.
authors: Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
authors: Yukiko
authors: Y
authors: Umeda
authors: Kazuo
authors: K
authors: Furihata
authors: Shohei
authors: S
authors: Sakuda
authors: Hiromichi
authors: H
authors: Nagasawa
authors: Ken
authors: K
authors: Ishigami
authors: Hidenori
authors: H
authors: Watanabe
authors: Miho
authors: M
authors: Izumikawa
authors: Motoki
authors: M
authors: Takagi
authors: Takayuki
authors: T
authors: Doi
authors: Yoichi
authors: Y
authors: Nakao
authors: Kazuo
authors: K
authors: Shin-ya
mesh_terms: D000091342:Endoplasmic Reticulum Chaperone BiP; D005947:Glucose / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology*; D018832:Molecular Chaperones / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000091342:Endoplasmic Reticulum Chaperone BiP; C000717247:HSPA5 protein, human; D006360:Heat-Shock Proteins; D018942:Macrolides; D018832:Molecular Chaperones; D009930:Organic Chemicals; D010456:Peptides, Cyclic; C447401:SW-163A; C501241:prunustatin A; C002699:neoantimycin; D005947:Glucose