Increased beta-2 microglobulinuria in human immunodeficiency virus-1-infected children and adolescents treated with tenofovir.
A single-center cross sectional evaluation of beta-2 micro-globinuria as a marker of proximal renal tubule damage in 92 HIV-infected children showed that tenofovir treatment was significantly associated with very high abnormal values. In view of the very long duration of treatments for HIV infection, their possible consequences for the child's growing body should be carefully evaluated.
Papaleo
Andrea
A
Unité d'Immunologie Hématologie Pédiatriques, Hôpital Necker Enfants Malades Assistance Publique-Hôpitaux de Paris (APHP) et Faculté de médecine René Descartes, (EA 3620) Université Paris V, Paris, France.
Warszawski
Josiane
J
Salomon
Rémi
R
Jullien
Vincent
V
Veber
Florence
F
Dechaux
Michèle
M
Blanche
Stéphane
S
D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000009:adverse effects*; D011507:Proteinuria; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects; D000068698:Tenofovir; D014556:Urine / Q000737:chemistry*; D001613:beta 2-Microglobulin / Q000032:analysis*
D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D001613:beta 2-Microglobulin; D000068698:Tenofovir; D000225:Adenine