title: The effects of antenatal smoking on lung function and respiratory symptoms in infants and children.
abstract: We highlight evidence demonstrating antenatal smoking exposure is an important risk factor for increased respiratory symptoms and lung function abnormalities in infants and children. Epidemiological studies have demonstrated an excess both of wheezing in the first two years after birth and asthma and persistent wheezing in older children. Lung function testing in children exposed to antenatal smoking has demonstrated a reduction in airway function. Antenatal exposure of nicotine to animal models results in pulmonary hypoplasia, fewer but larger alveoli and altered airway morphology. Pulmonary function testing, however, has not demonstrated that infant lung volume is affected by antenatal smoking exposure, other than due to the expected effect of smoking on somatic growth, but there is an adverse effect on airway development. There is no evidence that antenatal smoking exposure increases bronchial hyperreactivity, rather it may be associated with a diminished response to both bronchoconstrictors and bronchodilators in infants.
authors: Division of Asthma, Allergy and Lung Biology, MRC-Asthma Centre, King's College London, King's College Hospital, Denmark Hill, London, SE5 9RS, UK.
authors: Anthony D
authors: AD
authors: Milner
authors: Harish
authors: H
authors: Rao
authors: Anne
authors: A
authors: Greenough
mesh_terms: D000818:Animals; D002648:Child; D005260:Female; D005540:Forced Expiratory Flow Rates / Q000187:drug effects; D017408:Guidelines as Topic; D006801:Humans; D007223:Infant; D008168:Lung / Q000187:drug effects*; D008176:Lung Volume Measurements; D018811:Maternal Exposure; D023421:Models, Animal; D011247:Pregnancy; D012129:Respiratory Function Tests; D012907:Smoking / Q000009:adverse effects*