title: Serotonin receptor 1A C(-1019)G polymorphism associated with premenstrual dysphoric disorder.
abstract: OBJECTIVE
  To assess whether the G allele of the serotonin receptor 1A C(-1019)G polymorphism is associated with premenstrual dysphoric disorder.
  
  
  METHODS
  The study sample comprised 53 women with clinically diagnosed premenstrual dysphoric disorder (age range 27-46 years, mean 37.7 years) and 51 healthy control subjects (age range 22-48 years, mean 36.2 years). The serotonin receptor 1A C(-1019)G polymorphism was genotyped and compared between the two groups.
  
  
  RESULTS
  In contrast to the postulated "high-risk" G/G genotype, there was a marked overrepresentation of the C/C genotype in the premenstrual dysphoric disorder group (P=.034; odds ratio 3.63, 95% confidence interval 1.22-10.78). The presence of at least one C allele was associated with a 2.5-fold increased risk of premenstrual dysphoric disorder (P=.053; odds ratio 2.46, 95% confidence interval 1.03-5.88).
  
  
  CONCLUSIONS
  Our hypothesis that the high-risk G allele is associated with the occurrence of premenstrual dysphoria was not proved in this study. However, due to the increased prevalence of the C variant, we suggest that the C(-1019) allele may contribute to the risk of premenstrual dysphoria.
  
  
  METHODS
  II.
authors: Academic Unit of Obstetrics and Gynecology, Keele University Medical School, University Hospital of North Staffordshire, United Kingdom.
authors: Vandana
authors: V
authors: Dhingra
authors: Julia L
authors: JL
authors: Magnay
authors: P M Shaughn
authors: PM
authors: O'Brien
authors: Gail
authors: G
authors: Chapman
authors: Anthony A
authors: AA
authors: Fryer
authors: Khaled M K
authors: KM
authors: Ismail
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011293:Premenstrual Syndrome / Q000235:genetics* / Q000523:psychology; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D012307:Risk Factors
chemical_list: D044282:Receptor, Serotonin, 5-HT1A