title: Palladium-catalyzed alpha-vinylation of carbonyl compounds.
abstract: A mild, general, catalytic system for the alpha-vinylation of carbonyl compounds has been developed. By employing [Pd(P(t)Bu(3))Br](2) as catalyst and LHMDS as base, vinyl bromides, vinyl triflates, and vinyl tosylates couple with 3-methyloxindole in satisfactory yields. The same catalytic system is extended to the alpha-vinylation of ketones and esters.
authors: Chemical Process R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. jhuang@amgen.com
authors: Jinkun
authors: J
authors: Huang
authors: Emilio
authors: E
authors: Bunel
authors: Margaret M
authors: MM
authors: Faul