Hepatoprotective activity of Clerodendrum inerme against CCl4 induced hepatic injury in rats.
The ethanolic extract of Clerodendrum inerme leaves were screened for its hepatoprotective activity in CCl4 (0.5 ml/kg, i.p) induced liver damage in Swiss albino rats at a dose of 200 mg /kg bw. The ethanolic extract of C. inerme significantly (P<0.001) decreases the serum enzyme alanine amino transferase (ALT), asparate amino transferase (AST), alkaline phosphates (ALP), triglycerides (TGL), total cholesterol (TC) and significantly increased the glutathione level. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001). The extract did not shown any mortality up to a dose of 2000 g/kg bw.
Gopal
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Balaji Institute of PharmaceuticalSciences, Laknaepally, Narsampet, Warnagal-561 331, Andhra Pradesh, India. ngl72@yahoo.com
Sengottuvelu
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D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D032409:Clerodendrum; D008099:Liver / Q000187:drug effects*; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D010936:Plant Extracts; D020011:Protective Agents; D014280:Triglycerides; D002784:Cholesterol; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase