[The role of cytokines in the development of endothelial dysfunction in simple cardiac anomalies].
One hundred and twenty patients aged 18 to 32 years with echocardiographically verified simple cardiac anomalies (SCA) within the framework of non-differentiated connective tissue dysplasia (CTD). Immune-enzyme assay was used to measure serum levels of cytokines taking part in the regulation of endothelial function, such as the main factor of fibroblast growth, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma). The study revealed that the levels of fibroblast growth factor and IL-1beta were increased, while the serum levels of TNF-alpha and IFN-gamma were lowered. The alterations were most evident in cases of multiple SCA, myxomatous degeneration of a prolapsing mitral valve, and mitral regurgitation of higher than I degree. The determination of cytokine profile in patients with SCA may be used to stratificate the risk of cardiovascular complications in the heterogenous group of patients with nondifferentiated CTD.
Iagoda
A V
AV
Gladkikh
N N
NN
D000293:Adolescent; D000328:Adult; D003238:Connective Tissue / Q000503:physiopathology; D016207:Cytokines / Q000276:immunology*; D004452:Echocardiography; D004727:Endothelium / Q000276:immunology* / Q000503:physiopathology*; D005260:Female; D006331:Heart Diseases / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000453:epidemiology / Q000276:immunology; D014263:Tricuspid Valve Prolapse / Q000453:epidemiology / Q000276:immunology
D016207:Cytokines