Nephrotic syndrome resulting from focal segmental glomerulosclerosis in a peripheral blood stem cell transplant patient.
We describe the case of a male patient who was diagnosed with acute monoblastic leukemia and received a peripheral stem cell transplantation (PSCT) with peripheral blood hematopoietic progenitors. Because he was in clinical remission with no evidence of chronic graft-versus-host disease (GVHD), immunosuppression was withdrawn, and he developed nephrotic syndrome (NS) months later. A kidney biopsy showed focal segmental glomerulosclerosis (FSGS) as part of the GVHD. Soon after the reintroduction of previous immunosuppressive therapy, we observed a complete remission of the NS.
Heras
Manuel
M
Department of Nephrology, Segovia General Hospital, Segovia, Spain.
Saiz
Ana
A
Sánchez
Rosa
R
Fernandez-Reyes
Maria José
MJ
Mampaso
Francisco
F
Queizán
José  Antonio
J
Molina
Alvaro
A
Vázquez
Lourdes
L
Alvarez-Ude
Fernando
F
D000328:Adult; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006086:Graft vs Host Disease / Q000150:complications* / Q000276:immunology / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D007948:Leukemia, Monocytic, Acute / Q000628:therapy; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy