Torsade de pointes associated with moxifloxacin: a rare but potentially fatal adverse event.
Torsade de pointes occuring due to a long QT interval is a rare but potentially fatal arrhythmia. Acquired long QT develops most commonly because of drugs that prolong ventricular repolarization. It has been reported that fluoroquinolone antimicrobials prolong the corrected QT interval but rarely cause torsade de pointes. A patient with torsade de pointes risk factors (female sex, advanced age, extreme bradycardia and renal failure) who developed the condition on the fourth day of 400 mg/day of oral moxifloxacin treatment is presented. After the moxifloxacin was stopped, the corrected QT interval normalized and a permanent cardiac pacemaker was implanted. During 11 months of follow-up, arrhythmia did not recur.
Altin
T
T
Ankara University School of Medicine, Ankara, Turkey. alitimaltin@yahoo.com
Ozcan
O
O
Turhan
S
S
Ongun Ozdemir
A
A
Akyurek
O
O
Karaoguz
R
R
Guldal
M
M
D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001372:Aza Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D001919:Bradycardia; D002304:Cardiac Pacing, Artificial; D005260:Female; D024841:Fluoroquinolones / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000150:complications; D000077266:Moxifloxacin; D011014:Pneumonia / Q000188:drug therapy; D011804:Quinolines / Q000009:adverse effects* / Q000627:therapeutic use; D012307:Risk Factors; D013575:Syncope; D016171:Torsades de Pointes / Q000209:etiology*; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin