title: Growth hormone receptor; mechanism of action.
abstract: The growth hormone receptor has been an archetype for ligand-induced receptor dimerisation in cytokine receptor signalling. However, we now know that it exists as a constitutive dimer and is activated by a reorganisation of receptor subunits as a result of asymmetric placement of two receptor binding sites on the hormone monomer. This review highlights several topics including: current models of receptor activation; recent advances in the understanding of GH signalling demonstrating that ligand-induced signalling activates Src/ERK pathway in parallel to the classical JAK2-STAT5 signalling; and the nuclear localised growth hormone receptor correlates with high proliferation status and carcinogenesis.
authors: Institute for Molecular Bioscience, and School of Biomedical Sciences, University of Queensland, St Lucia, Queensland 4072, Australia. a.brooks@imb.uq.edu.au
authors: Andrew J
authors: AJ
authors: Brooks
authors: Jong Wei
authors: JW
authors: Wooh
authors: Kathryn A
authors: KA
authors: Tunny
authors: Michael J
authors: MJ
authors: Waters
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D021381:Protein Transport; D011986:Receptors, Somatotropin / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011986:Receptors, Somatotropin