The recognition, physiology, and treatment of medication-induced methemoglobinemia: a case report.
Dapsone is a leprostatic agent commonly prescribed for the management of leprosy, malaria, and the immunosuppression-induced infections of Pneumocystis carinii and Toxoplasma gondii. In susceptible patients, methemoglobinemia, a potentially life-threatening event, can occur. We report a case of dapsone-induced methemoglobinemia which was observed during general anesthesia for the management of a fractured mandible. The pathophysiology, diagnosis, and management of dapsone-induced methemoglobinemia will be discussed.
Turner
Michael D
MD
Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, New York 10010-4086, USA. mdt4@nyu.edu
Karlis
Vasiliki
V
Glickman
Robert S
RS
D000768:Anesthesia, General / Q000009:adverse effects*; D003622:Dapsone / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000009:adverse effects*; D008337:Mandibular Fractures / Q000601:surgery; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged
D007917:Leprostatic Agents; D003622:Dapsone