Association of atrial arrhythmia and sinus node dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia.
BACKGROUND
This study was performed to investigate the frequency and importance of supraventricular arrhythmia and sinus node (SN) dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT).


RESULTS
Eight patients with CPVT (mean age: 16.8+/-8.1 years) underwent an electrophysiological study. SN recovery time (1,389+/-394 ms) was slightly prolonged, and 4 of 8 patients had abnormal values. Atrial flutter (AF) was induced by low-rate atrial pacing in 2 patients and by isoproterenol infusion in 1 patient. Atrial fibrillation (Af) was induced by isoproterenol infusion in 2 patients. One patient presented with Af during the follow-up period, and 2 of 4 patients with AF/Af presented with increased SN recovery time.


CONCLUSIONS
Patients with CPVT frequently have associated with SN dysfunction, and inducible atrial tachyarrhythmias, which indicate that the pathogenesis of CPVT is limited not only to the ventricular myocardium, but also to broad regions of the heart, including the SN and atrial muscle.
Sumitomo
Naokata
N
Department of Pediatrics, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan. naokata@med.nihon-u.ac.jp
Sakurada
Harumizu
H
Taniguchi
Kazuo
K
Matsumura
Masaharu
M
Abe
Osamu
O
Miyashita
Michio
M
Kanamaru
Hiroshi
H
Karasawa
Kensuke
K
Ayusawa
Mamoru
M
Fukamizu
Seiji
S
Nagaoka
Iori
I
Horie
Minoru
M
Harada
Kensuke
K
Hiraoka
Masayasu
M
D000293:Adolescent; D000328:Adult; D001146:Arrhythmia, Sinus / Q000150:complications* / Q000503:physiopathology*; D054849:Cardiac Electrophysiology; D002316:Cardiotonic Agents / Q000494:pharmacology; D002648:Child; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D012849:Sinoatrial Node / Q000187:drug effects / Q000503:physiopathology*; D017180:Tachycardia, Ventricular / Q000150:complications* / Q000503:physiopathology*
D002316:Cardiotonic Agents; D007545:Isoproterenol