Comparison of automated assays for the determination of vitamin B12 in serum.
OBJECTIVE
To study the agreement of serum cobalamin results obtained with three different widely used analyzers.


METHODS
Comparative measurement of 100 serum samples was performed using the Abbott Architect, the Bayer Centaur, and the Roche Elecsys 2010 analyzer.


RESULTS
Relatively close numeric correlation of the results was found with Pearson's r>0.95 for all three comparisons; however, the mean concentration of the highest reading and the lowest reading method differed by 16%.


CONCLUSIONS
Relatively good agreement of results from three automated serum cobalamin assays was observed.
Vogeser
Michael
M
Institute of Clinical Chemistry, Hospital of the University of Munich, Marchioninistr. 15, D-81377 Munich, Germany. Michael.Vogeser@med.uni-muenchen.de
Lorenzl
Stefan
S
D019963:Clinical Chemistry Tests / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D015203:Reproducibility of Results; D014805:Vitamin B 12 / Q000097:blood*
D014805:Vitamin B 12