title: Clinical improvement and shrinkage of uterine fibroids after thermal ablation by magnetic resonance-guided focused ultrasound surgery.
abstract: OBJECTIVE
  Hysterectomy or myomectomy are the accepted treatments for symptomatic uterine fibroids. Heat ablation of uterine fibroids has been shown to be an effective alternative treatment. The aim of this study was to determine the clinical efficacy of non-invasive thermal ablation by transcutaneous magnetic resonance-guided high-intensity focused ultrasound (MRgFUS) for the treatment of symptomatic uterine fibroids.
  
  
  METHODS
  In this prospective study, MRgFUS ablation of uterine fibroids was performed in 35 symptomatic women scheduled for hysterectomy. Clinical symptoms, patient satisfaction and uterine size were determined at 1 month and 6 months after the procedure.
  
  
  RESULTS
  This outpatient procedure was very well tolerated by all women. Sixty-nine percent (24/35) of the treated patients reported either significant or partial improvement in symptoms. Treated fibroids decreased in volume by 12% and 15% at 1 and 6 months, respectively. Minor transient side-effects were observed in two women. Six women underwent hysterectomy during the follow-up period.
  
  
  CONCLUSIONS
  This study demonstrates the clinical efficacy of MRgFUS ablation of uterine fibroids. This novel, non-invasive surgical approach may offer an alternative therapy for women with uterine fibroids.
authors: Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat Gan, Israel.
authors: J
authors: J
authors: Rabinovici
authors: Y
authors: Y
authors: Inbar
authors: A
authors: A
authors: Revel
authors: Y
authors: Y
authors: Zalel
authors: J M
authors: JM
authors: Gomori
authors: Y
authors: Y
authors: Itzchak
authors: E
authors: E
authors: Schiff
authors: S
authors: S
authors: Yagel
mesh_terms: D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000473:pathology / Q000601:surgery*; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*