title: Interactions of angiotensin IV and oxytocin on behaviour in mice.
abstract: BACKGROUND
  Angiotensin (Ang) IV enhances learning and memory in rats but there are strain differences in its effects in mice. Oxytocin (OT) also influences learning and memory in rats and mice and, in the light of the proposed effects of Ang IV on oxytocinase, the hypothesis that the effects of Ang IV on cognition in mice involve OT was tested.
  
  
  METHODS
  The effects of Ang IV and OT, alone and combined, were determined in rat isolated uterine smooth muscle and in object recognition and forced swim tests in BKW mice.
  
  
  RESULTS
  Ang potentiated the contractile effects of OT in the uterus. Neither peptide had any effect on object recognition nor locomotor activity. Ang IV had no effect in the forced swim test but abolished the effects of OT.
  
  
  CONCLUSIONS
  Ang IV influences the actions of OT in vitro and in vivo, possibly by inhibition of oxytocinase, but the lack of effect of Ang IV on object recognition in BKW mice is unlikely to be a consequence of a deficiency endogenous OT. Unlike OT, Ang IV alone has no effect on learned helplessness in the forced swim test, an effect often used to predict potential antidepressant efficacy in humans.
authors: School of Pharmacy & Biomolecular Sciences, University of Brighton, Brighton, UK. p.r.gard@brighton.ac.uk
authors: Paul R
authors: PR
authors: Gard
authors: Pauline
authors: P
authors: Daw
authors: Zhila Sayyad
authors: ZS
authors: Mashhour
authors: Paula
authors: P
authors: Tran
mesh_terms: D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D006380:Helplessness, Learned; D066298:In Vitro Techniques; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology; D010120:Oxytocics / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D010364:Pattern Recognition, Visual / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects* / Q000502:physiology
chemical_list: D004338:Drug Combinations; D010120:Oxytocics; D000804:Angiotensin II; C012877:angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-; D010121:Oxytocin