[Fibrinogens and their role in atherogenesis in diabetes mellitus].
In the recent years, measurement of blood level of fibrinogen has been treated very seriously and this parameter has been considered an individual cardiovascular risk factor. A correlation between serum fibrinogen and the frequency of acute myocardial or cerebral ischemia has been found in a large number of studies. A distinct association between a high fibrinogen level and vascular complications in diabetic patients has been revealed as well. Two types of fibrinogen--high molecular weight fibrinogen (HMWF) weighing 340 kD, and low molecular weight fibrinogen (LMWF), weighing 280 kD and lacking a certain part of A alpha-polypeptide chain, are known today. B. Lipinski created a technique to measure the content of LMWF in blood serum, which made it possible to study the role played by this protein in the clinical presentation of atherothrombosis in diabetic patients. This work presents the results of research into the role of LMWF in the clinical picture of atherothrombosis in patients with type 2 diabetes mellitus. According to the localization of the manifestation of arterial ischemia and the presence of diabetes, three groups ofpatients were formed. The study revealed significantly higher LMWF level in all the three groups compared to controls. The LMWF/total blood fibrinogen ratio was also elevated.
Doronina
A M
AM
Lipinskiĭ
B
B
Bokarev
I N
IN
D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D003328:Coronary Thrombosis / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D005340:Fibrinogen / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D005340:Fibrinogen