Is there a functional correlate of Kv1.5 in the ventricle of canine heart and what would it mean for the use of I(Kur) blockers?
The cardiac ultrarapid outward current I(Kur), encoded by KCNA5, is of special pharmacological interest, because it is considered to be atrium-specific. I(Kur) has therefore become a target in the therapy of atrial tachyarrhythmias. However, the concept of atrium specificity is only valid if a functional I(Kur) current is in fact absent from the ventricle. However, new work has detected a I(Kur)-like current in canine ventricular myocytes, sensitive to 4-aminopyridine and suppressed by the I(Kur) blocker DPO-1, findings that support the existence of a functional ventricular I(Kur). These indications are, however, indirect and more effort is needed to clarify unequivocally the putative role of an expectedly small I(Kur) component in the ventricle.
Wettwer
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Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Dresden, Germany. wettwer@mail.zih.tu-dresden.de
D000818:Animals; D004285:Dogs; D006321:Heart / Q000187:drug effects* / Q000502:physiology*; D006352:Heart Ventricles / Q000187:drug effects; D051666:Kv1.5 Potassium Channel / Q000235:genetics / Q000502:physiology*; D009928:Organ Specificity; D026902:Potassium Channel Blockers / Q000494:pharmacology*; D016276:Ventricular Function
D051666:Kv1.5 Potassium Channel; D026902:Potassium Channel Blockers