title: Cognitive-behavioral therapy for adolescents with inflammatory bowel disease and subsyndromal depression.
abstract: OBJECTIVE
  To examine the feasibility and efficacy of a manual-based cognitive-behavioral therapy (CBT) in reducing depressive symptomatology in adolescents with inflammatory bowel disease (IBD). Primary and Secondary Control Enhancement Therapy-Physical Illness (PASCET-PI) modified for youths with IBD was compared to treatment as usual (TAU), plus an information sheet about depression, without therapist contact using assessable patient analysis.
  
  
  METHODS
  Following assessment, participants 11 to 17 years old with IBD and mild to moderate subsyndromal depression were randomly assigned to PASCET-PI (n = 22) or comparison treatment (n = 19). Primary outcome measures at baseline (T1) and 12 to 14 weeks posttreatment (T2) were Children's Depression Inventory (child/parent report), Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS), Children's Global Assessment Scale, and Perceived Control Scale for Children.
  
  
  RESULTS
  The PASCET-PI group showed significantly greater improvement in Children's Depression Inventory (child/parent report), Children's Global Assessment Scale, and Perceived Control Scale for Children posttreatment than the comparison group.
  
  
  CONCLUSIONS
  Screening and treatment of depressive symptoms in pediatric settings is feasible. PASCET-PI may be an efficacious intervention for subsyndromal depression in adolescents with IBD, although comparison with a more active treatment is necessary to attribute the improvement to PASCET-PI.
  
  
  BACKGROUND
  URL: http://clinicaltrials.gov. Unique identifier: NCT00446238.
authors: Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School. Electronic address: szigethye@upmc.edu.
authors: Eva
authors: E
authors: Szigethy
authors: Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School.
authors: Elyse
authors: E
authors: Kenney
authors: Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School.
authors: Johanna
authors: J
authors: Carpenter
authors: Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School.
authors: Diana M
authors: DM
authors: Hardy
authors: Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School.
authors: Diane
authors: D
authors: Fairclough
authors: Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School.
authors: Athos
authors: A
authors: Bousvaros
authors: Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School.
authors: David
authors: D
authors: Keljo
authors: Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School.
authors: John
authors: J
authors: Weisz
authors: Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School.
authors: William R
authors: WR
authors: Beardslee
authors: Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School.
authors: Robert
authors: R
authors: Noll
authors: Drs. Szigethy, Keljo, and Noll and Ms. Hardy are with Children's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Departments of Psychiatry and Pediatrics; Drs. Bousvaros, Beardslee, DeMaso, Ms. Kenney, and Ms. Carpenter are with Children's Hospital Boston/Harvard Medical School, Departments of Psychiatry and Pediatrics; Dr. Fairclough is with the University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometry; Dr. Weisz is with the Judge Baker Children's Center/Harvard Medical School.
authors: David Ray
authors: DR
authors: DeMASO
mesh_terms: D000293:Adolescent; D002648:Child; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology*; D008297:Male; D012720:Severity of Illness Index; D016896:Treatment Outcome