title: Effects of topical travoprost and unoprostone on optic nerve head circulation in normal rabbits.
abstract: OBJECTIVE
  To evaluate the effect, and the duration of the effect, of topically administrated travoprost and unoprostone on optic nerve head (ONH) circulation in Dutch rabbits.
  
  
  METHODS
  First, travoprost (0.004% solution) or unoprostone (0.12% solution) was unilaterally instilled once, or once daily (travoprost) or twice daily (unoprostone) for 7 days in Dutch rabbits. The ONH tissue blood velocity (NB(ONH)) was measured using the laser speckle method at 30 and 60 min after a single instillation of travoprost or unoprostone, and before and at 1, 6, and 12 hr (travoprost or unoprostone) and 24 hr (travoprost only) after the last instillation of the aforementioned 7-day instillation regimen. Second, similar experiments were conducted with indomethacin (5 mg/kg) pretreatment.
  
  
  RESULTS
  Both travoprost and unoprostone significantly increased NB(ONH) only in the treated eyes after a single instillation (p = 0.011 to 0.038); this effect was abolished by indomethacin pretreatment. In the 7-day instillation regimen, NB(ONH) was increased by 11%, 40%, 17%, 16%, and 12% only in the treated eyes just before and at 1, 6, 12, and 24 hr after the final instillation of travoprost, respectively, and increased by 10%, 25%, 13%, and 14% only in the treated eyes just before and at 1, 6, 12 hr after the final instillation of the unoprostone, respectively.
  
  
  CONCLUSIONS
  Topical travoprost or unoprostone significantly increased the ONH blood velocity with a single instillation and the effect persisted for 24 hr after a 7-day instillation. The effects of these drugs against retinal and ONH circulation are probably associated with the production of endogenous prostaglandins.
authors: Toranomon Hospital Eye Clinic, Tokyo, Japan. ohashi.masaaki@nifty.ne.jp
authors: Masaaki
authors: M
authors: Ohashi
authors: Chihiro
authors: C
authors: Mayama
authors: Kiyoshi
authors: K
authors: Ishii
authors: Makoto
authors: M
authors: Araie
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects*; D003008:Cloprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D015237:Dinoprost / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004334:Drug Administration Schedule; D007322:Instillation, Drug; D009898:Optic Disk / Q000098:blood supply*; D011817:Rabbits; D012016:Reference Values; D013997:Time Factors; D000069557:Travoprost
chemical_list: D003008:Cloprostenol; C072630:isopropyl unoprostone; D015237:Dinoprost; D000069557:Travoprost