Peptide nucleic acids and the origin of life.
The possibilities of pseudo-peptide-DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed on the basis of literature data showing that this type of molecules might have formed on the primitive earth (or other places in the universe), as well as data indicating the possibilities of template-directed PNA chemical replication and ligation. In particular, the merits of an achiral prebiotic genetic material is discussed.
Nielsen
Peter E
PE
Department of Cellular and Molecular Medicine, University of Copenhagen, The Panum Institute, Blegdamsvej 3c, DK-2200 Copenhagen N. pen@imbg.ku.dk
D019143:Evolution, Molecular; D009690:Nucleic Acid Conformation; D000069497:Origin of Life; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D011487:Protein Conformation
D020135:Peptide Nucleic Acids