[The humoral immunity against diphtheria].
Results of the conducted study showed that naturally acquired antibacterial and postvaccinal antitoxic antibodies against diphtheria were found in human blood sera. Challenge of ADT-M toxoid to adults resulted in production of antitoxic as well as antibacterial antibodies in high concentrations. In response to challenge of ADT-M toxoid simultaneously with bacterial vaccine against diphtheria Codivac both antibacterial and antitoxic antibodies were synthesized in blood on optimal physiologic levels. This study revealed dynamics of some specific characteristics of humoral immune response after challenge of two different vaccines against diphtheria--ADT-M toxoid and Codivac vaccine.
Shmeleva
E A
EA
Baturina
I G
IG
Paramonova
Iu A
IuA
Perelygina
O V
OV
Korzhenkova
M P
MP
Sviridov
V V
VV
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D003353:Corynebacterium diphtheriae / Q000276:immunology*; D004165:Diphtheria / Q000097:blood*; D004166:Diphtheria Antitoxin / Q000097:blood*; D004168:Diphtheria Toxoid / Q000008:administration & dosage* / Q000276:immunology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D007114:Immunization; D008875:Middle Aged; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology
D000907:Antibodies, Bacterial; C069433:Codivac; D004166:Diphtheria Antitoxin; D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D017778:Vaccines, Combined