title: Defensins: antimicrobial peptides for therapeutic development.
abstract: A novel class of endogenous antimicrobial peptides called defensins has shown great versatility in their activity against a diverse range of microorganisms including bacteria, viruses and fungi. Their mode of action of bacterial cell lysis seems largely nonspecific and so promises to avert the development of resistance. These two features have made them an area of intense research activity and growing commercial interest. A successful multidisciplinary effort to investigate and develop novel defensins analogues has been established in Singapore that involves computer modeling, biochemistry, proteomics, chemical synthesis, molecular biology and clinical sciences.
authors: Singapore Consortium for Antimicrobial Peptides, National University of Singapore, Singapore.
authors: Chandra
authors: C
authors: Verma
authors: Shalin
authors: S
authors: Seebah
authors: Soo Mei
authors: SM
authors: Low
authors: Lei
authors: L
authors: Zhou
authors: Shou Ping
authors: SP
authors: Liu
authors: Jing
authors: J
authors: Li
authors: Roger W
authors: RW
authors: Beuerman
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D023082:Defensins / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D019281:Dimerization; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D008954:Models, Biological; D012846:Singapore
chemical_list: D000890:Anti-Infective Agents; D023082:Defensins