Pregabalin-induced generalized myoclonic status epilepticus in patients with chronic pain.
Pregabalin is often used for the treatment of chronic pain syndromes. We here describe two patients with chronic pain and pregabalin-induced myoclonic status epilepticus. Patients treated with pregabalin who experience sudden behavioral changes or mycloni should be investigated for this possible side effect, and pregabalin should be reduced or discontinued if myocloni or status epilepticus occurs.
Knake
S
S
Department of Neurology, Philipps University Marburg, Marburg, Germany. knake@staff.uni-marburg.de
Klein
K M
KM
Hattemer
K
K
Wellek
A
A
Oertel
W H
WH
Hamer
H M
HM
Rosenow
F
F
D000369:Aged, 80 and over; D000700:Analgesics / Q000009:adverse effects*; D002908:Chronic Disease; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D010146:Pain / Q000188:drug therapy; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives*
D000700:Analgesics; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid