title: Intramolecular hydroamination of difluoropropargyl amides: regioselective synthesis of fluorinated beta- and gamma-lactams.
abstract: Functionalized gem-difluoro beta- and gamma-lactams were synthesized through a novel intramolecular hydroamination reaction of difluoropropargyl amides. beta-Lactams were obtained via a Baldwin disfavored 4-exo-digonal cyclization using palladium acetate as the catalyst, whereas gamma-lactams were produced under basic conditions. Acid hydration of gamma-lactams produced ketoamides or hemiaminals selectively.
authors: Departamento de Química OrgAnica, Universidad de Valencia, E-46100 Burjassot, Spain. santos.fustero@uv.es
authors: Santos
authors: S
authors: Fustero
authors: Begoña
authors: B
authors: Fernández
authors: Paula
authors: P
authors: Bello
authors: Carlos Del
authors: CD
authors: Pozo
authors: Satoru
authors: S
authors: Arimitsu
authors: Gerald B
authors: GB
authors: Hammond