[Chronic hypoxia state as one of the factors of increased fluorescence of endogenous porphyrins in alive biological tissues].
The hypothesis about the influence of chronic hypoxia in soft alive tissues on the intensity of He-Ne laser-induced fluorescence of endogenous porphyrins in tissues in the red region of the optical spectrum is discussed. Some theoretical prerequisites for enormous accumulation of porphyrins in soft tissues in a number of pathological cases and diseases are presented. A method for conducting clinical experimental trials to verify the hypothesis with the use of up-to-date laser noninvasive fluorescent diagnostics is proposed. Both the theoretical reasoning and new clinical experimental data show that chronic hypoxia can be one of the factors responsible for the appearance of a strong and abnormal laser-induced fluorescent signal from biotissues in the spectrum range 600-800 nm, which is associated with abnormally high accumulation of endogenous porphyrins in tissues.
Gorenkov
R V
RV
Karpov
B N
BN
Rogatkin
D A
DA
Shumskiĭ
V I
VI
D000328:Adult; D002908:Chronic Disease; D005453:Fluorescence; D053421:Hand-Arm Vibration Syndrome / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis / Q000378:metabolism*; D007834:Lasers; D007855:Lead Poisoning / Q000175:diagnosis / Q000378:metabolism*; D008173:Lung Diseases, Obstructive / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D011166:Porphyrins / Q000032:analysis / Q000378:metabolism*; D011237:Predictive Value of Tests
D011166:Porphyrins