title: Effects of amphetamine and cocaine on the development of acute experimental allergic encephalomyelitis in Lewis rats.
abstract: The present experiment deals with the effects of amphetamine and cocaine on the development and course of experimental allergic encephalomyelitis (EAE) induced in Lewis rats. Rats were immunized at the age of eight weeks with purified myelin basic protein isolated from guinea pig brain in complete Freund's adjuvant. Drug administration and recording of EAE clinical signs was performed daily since day 1 post-immunization (PI). On day 14 and 28 PI, six rats per group were bled and sacrificed. Spinal cord was examined histologically for EAE lesions. In vivo administration of 0.5 and 1 mg/Kg of amphetamine or cocaine resulted in a dose-related enhancement of neurological and histological signs of acute EAE in comparison with control rats. Both drugs caused a reduction of latent period together with a delayed regression of neurological signs along with an increase in inflammation in the central nervous system in comparison with placebo. Human & Experimental Toxicology (2007) 26, 637-643.
authors: Neuroimmunology Laboratory, Department of Pharmacology, School of Medicine, Dentistry and Nursing, C/San Francisco, s/n. 15782 Santiago de Compostela, A Coruña, Spain.
authors: María J
authors: MJ
authors: Núñez
authors: José
authors: J
authors: Balboa
authors: Manuel
authors: M
authors: Rey-Méndez
authors: Julio
authors: J
authors: Brenlla
authors: Mercedes
authors: M
authors: González-Peteiro
authors: Elena
authors: E
authors: Rodrigo
authors: Manuel
authors: M
authors: Freire-Garabal
mesh_terms: D000661:Amphetamine / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D003042:Cocaine / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D008297:Male; D004676:Myelin Basic Protein; D051381:Rats; D011917:Rats, Inbred Lew; D013116:Spinal Cord / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
chemical_list: D000697:Central Nervous System Stimulants; D004676:Myelin Basic Protein; D005620:Freund's Adjuvant; D000661:Amphetamine; D003042:Cocaine