Effects of multivitamin supplementation on DNA damage in lymphocytes from elderly volunteers.
The aim of this study was to evaluate the effect of a mixture of vitamins and minerals on oxidative DNA damage and the resistance of DNA to H(2)O(2)-induced DNA strand breaks in lymphocytes from 80 elderly volunteers ex vivo by means of Comet assay. The intervention with vitamin complex decreased significantly the levels of DNA damage. Our results demonstrate that the vitamin complex was able to decrease H(2)O(2)-induced DNA breakage. Our data suggest that the consumption of some vitamins may reduce the effects of oxidative DNA damage and may be useful for attaining healthy aging.
Ribeiro
Marcelo Lima
ML
Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco, Av. São Francisco de Assis, 218. Jd. São José, Bragança Paulista, SP, Brazil. marcelo.ribeiro@saofrancisco.edu.br
Arçari
Demétrius Paiva
DP
Squassoni
Aline Candido
AC
Pedrazzoli
José
J
D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage*; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000037:antagonists & inhibitors / Q000633:toxicity; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D014815:Vitamins / Q000008:administration & dosage*
D000975:Antioxidants; D014815:Vitamins; D006861:Hydrogen Peroxide