title: Analysis of low molecular weight acids by negative mode matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
abstract: Free 9-aminoacridine base is demonstrated to be a suitable matrix for negative mode matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOFMS) analysis of a wide range of low molecular weight organic acids including aliphatic (from acetic to palmitic acid), aromatic acids, phytohormones (e.g. jasmonic and salicylic acids), and amino acids. Low limits of quantitation in the femtomolar range (jasmonic - 250 fmol; caffeic - 160 fmol and salicylic - 12.5 fmol) and linear detector response over two concentration orders in the pico- and femtomolar range are extremely encouraging for the direct study of such acids in complex biological matrices.
authors: Mass Spectrometry Research Group, Max Planck Institute for Chemical Ecology, Hans-Knöll-Str. 8, 07745 Jena, Germany.
authors: Rohit
authors: R
authors: Shroff
authors: Alexander
authors: A
authors: Muck
authors: Ales
authors: A
authors: Svatos
mesh_terms: D000143:Acids / Q000032:analysis*; D008832:Microchemistry; D008970:Molecular Weight; D036103:Nanotechnology; D009930:Organic Chemicals / Q000032:analysis*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
chemical_list: D000143:Acids; D009930:Organic Chemicals