title: Safety of carotid artery stenting for symptomatic carotid artery disease: a meta-analysis.
abstract: OBJECTIVE
  Clinical trials comparing carotid artery stenting (CAS) with carotid endarterectomy (CEA) for patients with symptomatic carotid artery disease have produced conflicting results. We performed a meta-analysis to systematically evaluate currently available data by comparing CAS with CEA in patients with symptomatic carotid artery disease.
  
  
  RESULTS
  We searched MEDLINE, Embase, ISI Web of Knowledge, Current Contents, International Pharmaceutical Abstracts databases, the Cochrane Central Register of Controlled Trials, and scientific meeting abstracts up to 31 October 2006 and then calculated summary risk ratios (RRs) for mortality, stroke, disabling stroke, and death using random- and fixed-effect models. Data from five trials with 2122 patients were pooled. There was no difference in risk of 30-day mortality (summary RR 0.57, 95% CI 0.22-1.47, P = 0.25), stroke (summary RR 1.64, 95% CI 0.67-4.00, P = 0.34), disabling stroke (summary RR 1.67, 95% CI 0.50-5.62, P = 0.50), death and stroke (summary RR 1.54, 95% CI 0.81-2.92, P = 0.19), or death and disabling stroke (summary RR 1.19, 95% CI 0.57-2.51, P = 0.64) among patients randomized to CAS, compared with CEA.
  
  
  CONCLUSIONS
  No significant differences could be identified between CAS and CEA in the treatment of patients with symptomatic carotid artery disease. Larger randomized controlled trials are warranted to compare the two strategies.
authors: Division of Cardiovascular Medicine, University of Michigan Health System, 2A 394, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0311, USA. hgurm@med.umich.edu
authors: Hitinder S
authors: HS
authors: Gurm
authors: Brahmajee K
authors: BK
authors: Nallamothu
authors: Jay
authors: J
authors: Yadav
mesh_terms: D000800:Angioplasty, Balloon; D016893:Carotid Stenosis / Q000601:surgery*; D016894:Endarterectomy, Carotid / Q000295:instrumentation*; D004869:Equipment Safety; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D015607:Stents; D016896:Treatment Outcome