title: Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes.
abstract: The synthesis of three acetylene functionalized BODIPY dyes is described. These dyes are used to fluorescently modify an azido functionalized epoxomicin analogue employing the Huisgen 1,3-dipolar cycloaddition, resulting in a panel of fluorescent epoxomicin derived proteasome probes.
authors: Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
authors: Martijn
authors: M
authors: Verdoes
authors: Ulrik
authors: U
authors: Hillaert
authors: Bogdan I
authors: BI
authors: Florea
authors: Myra
authors: M
authors: Sae-Heng
authors: Martijn D P
authors: MD
authors: Risseeuw
authors: Dmitri V
authors: DV
authors: Filippov
authors: Gijsbert A
authors: GA
authors: van der Marel
authors: Herman S
authors: HS
authors: Overkleeft
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002460:Cell Line; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry; D046988:Proteasome Endopeptidase Complex / Q000032:analysis* / Q000737:chemistry
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000480:Alkynes; D001896:Boron Compounds; D005456:Fluorescent Dyes; D009842:Oligopeptides; D046988:Proteasome Endopeptidase Complex; C078846:epoxomicin