A nine-day accelerated radiation protocol for feline squamous cell carcinoma.
Nine cats with oral squamous cell carcinoma were treated with an accelerated radiation protocol (14 fractions of 3.5 Gy in 9 days). Radiation was administered twice daily with a 6hour break between treatments. Median overall survival was 86 +/- 110 days. Median survival for cats with a partial response (n=6) was 60 +/- 7 days, while median survival for cats with a complete response (n=3) was 298 +/- 187 days (P = 0.0639). The accelerated protocol was well tolerated and toxicity in the early and late period was manageable in all cats. Further modification of the protocol is warranted to extend survival.
Fidel
Janean L
JL
Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164-6610, USA. jfidel@vetmed.wsu.edu
Sellon
Rance K
RK
Houston
Robert K
RK
Wheeler
Betsy A
BA
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000662:veterinary*; D002371:Cat Diseases / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D002415:Cats; D005260:Female; D008297:Male; D009062:Mouth Neoplasms / Q000532:radiotherapy / Q000662:veterinary*; D011829:Radiation Dosage; D011878:Radiotherapy / Q000662:veterinary; D016019:Survival Analysis; D016896:Treatment Outcome