title: Sirolimus for visceral and cutaneous Kaposi's sarcoma in a renal-transplant recipient.
abstract: The incidence of Kaposi's sarcoma among recipients of solid organs is about 500 times the rate in the general population, suggesting a role for immunosuppression in its development. On the basis of these findings, we investigated the impact of sirolimus on cutaneous and disseminated visceral Kaposi's sarcoma in a renal-transplant recipient. The introduction of sirolimus in this patient allowed complete regression of Kaposi's sarcoma (cutaneous and visceral) with preservation of excellent renal function. Meanwhile, in view of the available observational reports, we think that sirolimus should be included in the standard treatment for Kaposi's sarcoma after transplantation, to permit remission of the sarcoma (both cutaneous and visceral) while preserving the renal function.
authors: Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
authors: Osama
authors: O
authors: Gheith
authors: Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt. adelbakr2001@yahoo.com.
authors: Adel
authors: A
authors: Bakr
authors: Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
authors: Ehab
authors: E
authors: Wafa
authors: Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
authors: Ashraf
authors: A
authors: Fouda
authors: Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
authors: Amgad
authors: A
authors: El Agroudy
authors: Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
authors: Ayman
authors: A
authors: Refaie
authors: Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
authors: Ahmed
authors: A
authors: Donia
authors: Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
authors: Alaa
authors: A
authors: Sabry
authors: Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
authors: Mohamed
authors: M
authors: Sobh
authors: Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
authors: Ahmed
authors: A
authors: Shokeir
authors: Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
authors: Mohamed
authors: M
authors: Ghoneim
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000209:etiology; D020123:Sirolimus / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000209:etiology; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000903:Antibiotics, Antineoplastic; D020123:Sirolimus