The role of intracellular amyloid beta in Alzheimer's disease.
Extracellular amyloid beta (Abeta) that confers neurotoxicity and modulates synaptic plasticity and memory function has been central to the amyloid hypothesis of Alzheimer's disease (AD) pathology. Like many other misfolded proteins identified in neurodegenerative disorders, Abeta also accumulates inside the AD neurons. This intracellular Abeta affects a variety of cellular physiology from protein degradation, axonal transport, autophagy to apoptosis, further documenting the role of Abeta in AD. Therapeutics targeting intracellular Abeta could be effective treatment for AD.
Li
Meng
M
Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China.
Chen
Liying
L
Lee
Daniel Hong Seng
DH
Yu
Long-Chuan
LC
Zhang
Yan
Y
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism / Q000473:pathology
D016229:Amyloid beta-Peptides