title: Gender-specific effect of overexpression of sFlt-1 in pregnant mice on fetal programming of blood pressure in the offspring later in life.
abstract: OBJECTIVE
  The purpose of this study was to determine whether fetal programming of adult blood pressure is altered in a previously characterized mouse model of preeclampsia that was induced by sFlt-1.
  
  
  METHODS
  CD-1 mouse mothers at day 8 of gestation were injected with an adenovirus carrying Flt 1-3 (10(9) plaque-forming units) or with an adenovirus carrying mFc as control (10(9) plaque-forming units). The resulting pups were followed until 6 months of age, at which time blood pressure (BP) was recorded continuously for 6 days. The offspring weight was also recorded from weaning until adulthood.
  
  
  RESULTS
  BP was significantly higher in the male offspring that were born to sFlt-1-treated mothers compared with the controls. Male offspring from sFlt-1-treated mothers were significantly smaller from weaning until adulthood. However, there were no significant differences in BP and postweaning weight in female offspring between the 2 groups.
  
  
  CONCLUSIONS
  Our findings highlight the role of the intrauterine environment in the developmental origin of adult disease.
authors: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, TX 77555-1062, USA. falu@utmb.edu
authors: Fangxian
authors: F
authors: Lu
authors: Egle
authors: E
authors: Bytautiene
authors: Esther
authors: E
authors: Tamayo
authors: Phyllis
authors: P
authors: Gamble
authors: Garland D
authors: GD
authors: Anderson
authors: Gary D V
authors: GD
authors: Hankins
authors: Monica
authors: M
authors: Longo
authors: George R
authors: GR
authors: Saade
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001724:Birth Weight / Q000235:genetics / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D008297:Male; D051379:Mice; D011247:Pregnancy; D011897:Random Allocation; D012737:Sex Factors; D013686:Telemetry; D014162:Transfection; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C501163:Flt1 protein, mouse; D040281:Vascular Endothelial Growth Factor Receptor-1