title: Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans.
abstract: Microbial transformation of adrenosterone (1) by suspended-cell cultures of the filamentous fungus Cunninghamella elegans resulted in the production of five metabolites 2-6, which were identified as 9alpha-hydroxyadrenosterone (2), 11-ketotestosterone (3), 6beta-hydroxyadrenosterone (4), 9alpha-hydroxy-11-ketotestosterone (5), and 6beta-hydroxy-11-ketotestosterone (6). Structures of new metabolites 2, 5, and 6 were established by single-crystal X-ray diffraction analysis.
authors: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. hej@cyber.net.pk
authors: Muhammad Iqbal
authors: MI
authors: Choudhary
authors: Naik T
authors: NT
authors: Khan
authors: Syed G
authors: SG
authors: Musharraf
authors: Shazia
authors: S
authors: Anjum
authors: Atta-Ur-Rahman
mesh_terms: D000736:Androstenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D001711:Biotransformation; D018360:Crystallography, X-Ray; D020093:Cunninghamella / Q000378:metabolism*; D013058:Mass Spectrometry; D008968:Molecular Conformation
chemical_list: D000736:Androstenes; C011657:adrenosterone