title: Reversible acute fetal renal failure due to maternal exposure to angiotensin receptor blocker.
abstract: We report on a case of fetal toxicity due to maternal treatment with olmesartan medoxomil. At 29 weeks' gestation, oligohydramnios was found, although the fetus had normal kidneys on ultrasound evaluation. Withdrawal of olmesartan medoxomil, maternal rehydration, and a single dose of furosemide reversed the renal impairment. After term delivery, the neonate was confirmed to have normal renal function. The case suggested that fetal renal impairment due to olmesartan medoxomil may be reversible.
authors: Department of Obstetrics and Gynecology, University of Chieti, Via Sandro Pertini, 4, 65129, Pescara, Italy. ccelen@tin.it
authors: Claudio
authors: C
authors: Celentano
authors: Federico
authors: F
authors: Prefumo
authors: Elena
authors: E
authors: di Vera
authors: Annamaria
authors: A
authors: Iannicco
authors: Davide Pio
authors: DP
authors: Gallo
authors: Marco
authors: M
authors: Liberati
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects*; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D005665:Furosemide / Q000627:therapeutic use; D005865:Gestational Age; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D016104:Oligohydramnios / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D000068557:Olmesartan Medoxomil; D011247:Pregnancy; D011296:Prenatal Diagnosis; D020127:Recovery of Function; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D013777:Tetrazoles / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D004232:Diuretics; D007093:Imidazoles; D013777:Tetrazoles; D000068557:Olmesartan Medoxomil; D005665:Furosemide