Doxycycline sustained release from brushite cements for the treatment of periodontal diseases.
Doxycycline (DOXY) is a wide spectrum antibiotic used in the treatment of dental, periodontal, and bone infections. Brushite cements are calcium phosphate biomaterials especially interesting for bone regeneration processes. In this work, we describe the preparation of a brushite cement containing DOXY and the drug release from the cement. DOXY solutions were mixed with the cement powder and after a 50% burst release in the first 12 h, a slow and controlled release was achieved over 3.5 days. The release of DOXY hyclate was controlled by both, diffusion and Ca(2+) interaction. Formation of DOXY-Ca(2+) chelates was detected in the cement structure using solid state fluorescence. The brushite cement loaded with DOXY hyclate had antibacterial activity against periodontal pathogens: Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Bacteroides frosthytus. This new biomaterial may be helpful for the treatment of periodontal diseases.
Tamimi
Faleh
F
Departamento de Quimica Física II, Universidad Complutense de Madrid, 28040 Madrid, Spain. fdamimim@farm.ucm.es
Torres
Jesús
J
Bettini
Ruggero
R
Ruggera
Francesca
F
Rueda
Carmen
C
López-Ponce
Manuel
M
Lopez-Cabarcos
Enrique
E
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001419:Bacteria / Q000187:drug effects; D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; D003738:Dental Cements / Q000737:chemistry* / Q000627:therapeutic use; D004318:Doxycycline / Q000008:administration & dosage*; D007700:Kinetics; D008422:Materials Testing; D010510:Periodontal Diseases / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; D003738:Dental Cements; D004318:Doxycycline; C494366:calcium phosphate, dibasic, dihydrate