Proliferation, hyperplasia, neogenesis, and neoplasia in the islets of Langerhans.
Pancreatic disease is responsible for significant morbidity and mortality as a result of pancreatic carcinoma and diabetes mellitus. Regulation of endocrine cell mass is thought to have a central role in the pathogenesis of both these diseases. Islet cell proliferation, hypertrophy, neogenesis, and apoptosis are the main determinants of endocrine cell mass in the pancreas, and their understanding has been improved by new clues of their genetic and molecular basis. Beta cells have attracted most research interest because of potential implications in the treatment of diabetes mellitus and hypoglycemic disorders. The processes that operate during pancreatic adaptation to a changing hormonal milieu are important in pancreatic carcinogenesis. There is evidence that somatostatin and its receptors are fundamental regulators of endocrine cell mass and are involved in islet tumorigenesis.
Ballian
Nikiforos
N
Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.
Hu
Min
M
Liu
Shi-He
SH
Brunicardi
F Charles
FC
D000818:Animals; D002455:Cell Division; D006224:Cricetinae; D025461:Feedback, Physiological; D005947:Glucose / Q000502:physiology; D006728:Hormones / Q000502:physiology; D006801:Humans; D006965:Hyperplasia; D006984:Hypertrophy; D007340:Insulinoma / Q000473:pathology; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D007515:Islets of Langerhans / Q000166:cytology* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D009929:Organ Size; D010190:Pancreatic Neoplasms / Q000473:pathology*; D039904:Pluripotent Stem Cells / Q000166:cytology; D015398:Signal Transduction / Q000502:physiology; D013045:Species Specificity
D006728:Hormones; D036341:Intercellular Signaling Peptides and Proteins; D005947:Glucose