title: Human papillomavirus (HPV) genotype distribution in invasive cervical cancers in France: EDITH study.
abstract: Invasive cervical cancer (ICC) remains a significant cause of morbidity and mortality in France. Since human papillomavirus (HPV) is the necessary cause of ICC, the aim of this study was to assess the type-specific prevalence of HPV in ICC in France in order to locally evaluate the potential benefit of an HPV 16/18 L1 virus-like particles (VLP) vaccination. A total of 516 histological specimens collected in 15 centers were analyzed. Among them, 86% had a diagnosis of squamous cell carcinoma (SCC) whereas 14% were adenocarcinomas (ADC). HPV genotyping was performed using the INNO-LiPA assay allowing the specific detection of 24 HPV genotypes both high risk (HR) and low risk (LR). The overall HPV prevalence in ICC was 97%. The most prevalent genotypes were HPV 16 (73%) and HPV 18 (19%) followed by HPV 31 (7%), 33, 68, 45, 52 and 58 (4.1-2.3%). HPV 16 and/or 18 were associated with 82% of ICC, 10% being HPV 16 and 18 coinfections. While HPV 16 was the most prevalent type in both SCC (74%) and ADC (64%), HPV 18 was by far more prevalent in ADC (37%) compared to SCC (16%; p < 0.001). Multiple infections with at least two different HR HPV genotypes were observed in 22% of ICC. Given the high HPV 16/18 prevalence and taking into account possible production of crossneutralizing antibodies against other HPV types, HPV 16/18 L1 VLP vaccination would be expected to significantly reduce the burden of ICC in France.
authors: EA3181, IFR133, CHU Besançon, Besançon, France. luc.pretet@univ-fcomte.fr
authors: Jean-Luc
authors: JL
authors: Prétet
authors: Anne-Carole
authors: AC
authors: Jacquard
authors: Xavier
authors: X
authors: Carcopino
authors: Jean-François
authors: JF
authors: Charlot
authors: Damien
authors: D
authors: Bouhour
authors: Bernadette
authors: B
authors: Kantelip
authors: Benoit
authors: B
authors: Soubeyrand
authors: Yann
authors: Y
authors: Leocmach
authors: Christiane
authors: C
authors: Mougin
authors: Didier
authors: D
authors: Riethmuller
mesh_terms: D000328:Adult; D000368:Aged; D019496:Cancer Vaccines; D005260:Female; D005602:France; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics / Q000821:virology; D015995:Prevalence; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000821:virology*
chemical_list: D019496:Cancer Vaccines