title: Increased beta-2 microglobulinuria in human immunodeficiency virus-1-infected children and adolescents treated with tenofovir.
abstract: A single-center cross sectional evaluation of beta-2 micro-globinuria as a marker of proximal renal tubule damage in 92 HIV-infected children showed that tenofovir treatment was significantly associated with very high abnormal values. In view of the very long duration of treatments for HIV infection, their possible consequences for the child's growing body should be carefully evaluated.
authors: Unité d'Immunologie Hématologie Pédiatriques, Hôpital Necker Enfants Malades Assistance Publique-Hôpitaux de Paris (APHP) et Faculté de médecine René Descartes, (EA 3620) Université Paris V, Paris, France.
authors: Andrea
authors: A
authors: Papaleo
authors: Josiane
authors: J
authors: Warszawski
authors: Rémi
authors: R
authors: Salomon
authors: Vincent
authors: V
authors: Jullien
authors: Florence
authors: F
authors: Veber
authors: Michèle
authors: M
authors: Dechaux
authors: Stéphane
authors: S
authors: Blanche
mesh_terms: D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000009:adverse effects*; D011507:Proteinuria; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects; D000068698:Tenofovir; D014556:Urine / Q000737:chemistry*; D001613:beta 2-Microglobulin / Q000032:analysis*
chemical_list: D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D001613:beta 2-Microglobulin; D000068698:Tenofovir; D000225:Adenine