Vertical alveolar ridge augmentation using autogenous bone grafts and platelet-enriched fibrin glue with simultaneous implant placement.
OBJECTIVE
The aim of this study was to evaluate the combined use of autogenous bone and platelet-enriched fibrin glue as grafting material for vertical alveolar ridge augmentation with simultaneous implant placement in a canine alveolar ridge defect model.


METHODS
In 6 mongrel dogs, bilateral vertical alveolar ridge defects were created in the mandible. After 3 months of healing, 2 dental implants were placed in each defect of the mandible, creating 6-mm supra-alveolar peri-implant defects. The 2 implants per defect were subjected to surgical treatments involving either a combination of autogenous bone grafts and platelet-enriched fibrin glue, or a conventional flap procedure only (control). After a healing period of 6 months, the dogs were humanely killed for histological and histometric analyses.


RESULTS
Implant placement alone produced limited vertical alveolar height (0.6 +/- 0.4 mm). However, alveolar augmentation including a combination of autogenous bone grafts and platelet-enriched fibrin glue with simultaneous implant placement resulted in alveolar ridge augmentation amounting to 4.2 +/- 1.0 mm, comprising 63% of the defect height. New bone-implant contact was 40.5% in the defects treated with combined autogenous bone grafts and platelet-enriched fibrin glue, and was 48.4% in the resident bone; this difference was not statistically significant.


CONCLUSIONS
The present study demonstrates that vertical alveolar ridge augmentation using autogenous bone grafts and platelet-enriched fibrin glue with simultaneous implant placement might effectively increase vertical alveolar ridge height and allow for an acceptable level of osseointegration.
Lee
Hyeon-Jung
HJ
Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea.
Choi
Byung-Ho
BH
Jung
Jae-Hyung
JH
Zhu
Shi-Jiang
SJ
Lee
Seoung-Ho
SH
Huh
Jin-Young
JY
You
Tae-Min
TM
Li
Jingxu
J
D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001792:Blood Platelets; D016025:Bone Transplantation / Q000379:methods*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D004285:Dogs; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000737:chemistry / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000737:chemistry / Q000627:therapeutic use*; D016896:Treatment Outcome
D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives