The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study.
A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.
Frank
Bernd
B
Helmholtz-University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. b.frank@dkfz.de
Rigas
Sushila H
SH
Bermejo
Justo Lorenzo
JL
Wiestler
Miriam
M
Wagner
Kerstin
K
Hemminki
Kari
K
Reed
Malcolm W
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Sutter
Christian
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Wappenschmidt
Barbara
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Balasubramanian
Sabapathy P
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Meindl
Alfons
A
Kiechle
Marion
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Bugert
Peter
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Schmutzler
Rita K
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Bartram
Claus R
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Justenhoven
Christina
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Ko
Yon-Dschun
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Brüning
Thomas
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Brauch
Hiltrud
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Hamann
Ute
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Pharoah
Paul P D
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Dunning
Alison M
AM
Pooley
Karen A
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Easton
Douglas F
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Cox
Angela
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Burwinkel
Barbara
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D053181:Caspase 8 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D017384:Sequence Deletion; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D044465:White People
D053181:Caspase 8