title: Association of atrial arrhythmia and sinus node dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia.
abstract: BACKGROUND
  This study was performed to investigate the frequency and importance of supraventricular arrhythmia and sinus node (SN) dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT).
  
  
  RESULTS
  Eight patients with CPVT (mean age: 16.8+/-8.1 years) underwent an electrophysiological study. SN recovery time (1,389+/-394 ms) was slightly prolonged, and 4 of 8 patients had abnormal values. Atrial flutter (AF) was induced by low-rate atrial pacing in 2 patients and by isoproterenol infusion in 1 patient. Atrial fibrillation (Af) was induced by isoproterenol infusion in 2 patients. One patient presented with Af during the follow-up period, and 2 of 4 patients with AF/Af presented with increased SN recovery time.
  
  
  CONCLUSIONS
  Patients with CPVT frequently have associated with SN dysfunction, and inducible atrial tachyarrhythmias, which indicate that the pathogenesis of CPVT is limited not only to the ventricular myocardium, but also to broad regions of the heart, including the SN and atrial muscle.
authors: Department of Pediatrics, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan. naokata@med.nihon-u.ac.jp
authors: Naokata
authors: N
authors: Sumitomo
authors: Harumizu
authors: H
authors: Sakurada
authors: Kazuo
authors: K
authors: Taniguchi
authors: Masaharu
authors: M
authors: Matsumura
authors: Osamu
authors: O
authors: Abe
authors: Michio
authors: M
authors: Miyashita
authors: Hiroshi
authors: H
authors: Kanamaru
authors: Kensuke
authors: K
authors: Karasawa
authors: Mamoru
authors: M
authors: Ayusawa
authors: Seiji
authors: S
authors: Fukamizu
authors: Iori
authors: I
authors: Nagaoka
authors: Minoru
authors: M
authors: Horie
authors: Kensuke
authors: K
authors: Harada
authors: Masayasu
authors: M
authors: Hiraoka
mesh_terms: D000293:Adolescent; D000328:Adult; D001146:Arrhythmia, Sinus / Q000150:complications* / Q000503:physiopathology*; D054849:Cardiac Electrophysiology; D002316:Cardiotonic Agents / Q000494:pharmacology; D002648:Child; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D012849:Sinoatrial Node / Q000187:drug effects / Q000503:physiopathology*; D017180:Tachycardia, Ventricular / Q000150:complications* / Q000503:physiopathology*
chemical_list: D002316:Cardiotonic Agents; D007545:Isoproterenol