title: Heart rate variability derived from exercise ECG in the detection of coronary artery disease.
abstract: The diagnostic performance of heart rate variability (HRV) analysis from exercise ECG in the detection of coronary artery disease (CAD) is unknown. Bicycle exercise ECG recordings from The Finnish Cardiovascular Study (FINCAVAS) of angiography-proofed CAD patients (n = 112) and a patient group with a low likelihood of CAD (n = 114) were analyzed. HRV parameters (SDNN, RMSSD, Poincaré SD1 and SD2) were calculated from 1 min segments before exercise, during exercise and after exercise. All the parameters were in addition calculated from heart rate (HR)-corrected RR-interval segments. The ST-segment depressions in each stage were also determined. The diagnostic performance of the parameters was evaluated with the area under the receiver operating characteristic (ROC) curve method. The uncorrected HRV parameters showed the best diagnostic performance in the recovery segments but the correlation with HR was also high (SDNN: 0.758/-0.64, RMSSD: 0.747/-0.60; area under the ROC/correlation coefficient). The HR correction decreased the correlation and the diagnostic performance in recovery segments (SDNN: 0.515/-0.12, RMSSD: 0.609/0.20). The diagnostic performance of ST-level at its best was higher than any of HRV parameters (ST-level: 0.795/0.36). According to the results, the HR correction decreased the diagnostic performance of the recovery phase. The HRV parameters calculated from 1 min segments of exercise test ECG were not as capable as traditional ST-segment analysis. In conclusion, the HRV analysis from exercise or recovery phase seems to be inadequate in the detection of CAD.
authors: Ragnar Granit Institute, Tampere University of Technology, PO Box 692, FI-33101, Finland.
authors: Matti
authors: M
authors: Virtanen
authors: Mika
authors: M
authors: Kähönen
authors: Tuomo
authors: T
authors: Nieminen
authors: Pasi
authors: P
authors: Karjalainen
authors: Mika
authors: M
authors: Tarvainen
authors: Terho
authors: T
authors: Lehtimäki
authors: Rami
authors: R
authors: Lehtinen
authors: Kjell
authors: K
authors: Nikus
authors: Tiit
authors: T
authors: Kööbi
authors: Mari
authors: M
authors: Niemi
authors: Kari
authors: K
authors: Niemelä
authors: Väinö
authors: V
authors: Turjanmaa
authors: Jaakko
authors: J
authors: Malmivuo
authors: Jari
authors: J
authors: Viik
mesh_terms: D003324:Coronary Artery Disease / Q000175:diagnosis*; D004562:Electrocardiography / Q000379:methods*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve