title: Vernonia polyanthes as a new source of antiulcer drugs.
abstract: Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action.
authors: Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, s/n, CP 6109, CEP13083-970, Campinas, SP, Brazil. vicbio@yahoo.com
authors: Victor
authors: V
authors: Barbastefano
authors: Maira
authors: M
authors: Cola
authors: Anderson
authors: A
authors: Luiz-Ferreira
authors: Elisângela
authors: E
authors: Farias-Silva
authors: Clélia A
authors: CA
authors: Hiruma-Lima
authors: Daniel
authors: D
authors: Rinaldo
authors: Wagner
authors: W
authors: Vilegas
authors: Alba R M
authors: AR
authors: Souza-Brito
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D008297:Male; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D035741:Vernonia
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol