Effects on body weight and body composition of a low-dose oral estroprogestin containing ethinyl estradiol 20 microg plus levonorgestrel 100 microg.
Weight gain is a common problem reported by users of estroprogestins (EPs) and is a frequent reason for EP discontinuation, even if this problem is not confirmed in several clinical studies. We studied the impact of a EP containing ethinyl estradiol (EE) 20 microg plus levonorgestrel (LNG) 100 microg on body weight (BW) and body composition in 47 treated women and 31 women as controls. Also, we studied the effect of this association on metabolic parameters (glycemia, lipid profile). EE20/LNG100 had no significant impact on body weight, body composition (fat mass, fat-free mass, total body water, intracellular water, extracellular water) or metabolic profile in comparison with no treatment. Thus, the use of EE20/LNG100 showed no impact on metabolic parameters, body weight and body composition. This could be important not only for the safety profile of this combination, but also in increasing patient compliance.
Lello
Stefano
S
Department of Gynecology, IRCCS IDI-San Carlo, Rome, Italy. lellostefano@libero.it
Vittori
Giorgio
G
Paoletti
Anna Maria
AM
Sorge
Roberto
R
Guardianelli
Francesca
F
Melis
Gian Benedetto
GB
D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D017097:Electric Impedance; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage / Q000009:adverse effects*; D008055:Lipids / Q000097:blood
D001786:Blood Glucose; D008055:Lipids; D004997:Ethinyl Estradiol; D016912:Levonorgestrel