title: Genetic analysis of resistance to viral infection.
abstract: As machines that reprogramme eukaryotic cells to suit their own purposes, viruses present a difficult problem for multicellular hosts, and indeed, have become one of the central pre-occupations of the immune system. Unable to permanently outpace individual viruses in an evolutionary footrace, higher eukaryotes have evolved broadly active mechanisms with which to sense viruses and suppress their proliferation. These mechanisms have recently been elucidated by a combination of forward and reverse genetic methods. Some of these mechanisms are clearly ancient, whereas others are relatively new. All are remarkably adept at discriminating self from non-self, and allow the host to cope with what might seem an impossible predicament.
authors: Department of Genetics, The Scripps Research Institute, IMM-3-1, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA. bruce@scripps.edu
authors: Bruce
authors: B
authors: Beutler
authors: Celine
authors: C
authors: Eidenschenk
authors: Karine
authors: K
authors: Crozat
authors: Jean-Luc
authors: JL
authors: Imler
authors: Osamu
authors: O
authors: Takeuchi
authors: Jules A
authors: JA
authors: Hoffmann
authors: Shizuo
authors: S
authors: Akira
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D004198:Disease Susceptibility; D024882:Drug Resistance, Viral / Q000235:genetics; D005057:Eukaryotic Cells / Q000276:immunology / Q000821:virology; D006801:Humans; D007109:Immunity / Q000235:genetics*; D009154:Mutation; D014777:Virus Diseases / Q000276:immunology*; D014780:Viruses / Q000187:drug effects / Q000235:genetics
chemical_list: D000998:Antiviral Agents