A case of manic episode during treatment with 5-fluorouracil, epirubicin and cyclophosphamide for breast cancer.
A 41-year-old woman with breast cancer developed a manic episode while being treated with a 5-fluorouracil-epirubicin-cyclophosphamide combination (most likely caused by the first drug). Chemotherapy was discontinued, and antipsychotic treatment with haloperidol and olanzapine was instituted. She recovered after 10 days. Normal computerized tomography (CT) scans and neurological examinations were consistent with the absence of neurological symptoms on physical exam.
Pacchiarotti
Isabella
I
Unit of Psychiatry, Department of Neurosciences, Sant'Andrea Hospital, 2nd Medical School, Sapienza University, 00189 Rome, Italy. isabella.pacchiarotti@uniroma1.it
Mazzarini
Lorenzo
L
Pellegrini
Patrizia
P
Venturelli
Viola
V
Sani
Gabriele
G
Sánchez-Moreno
José
J
Mancinelli
Iginia
I
Tatarelli
Roberto
R
Kotzalidis
Giorgio D
GD
Girardi
Paolo
P
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000139:chemically induced*; D001943:Breast Neoplasms / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D015251:Epirubicin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D007558:Italy
D000903:Antibiotics, Antineoplastic; D018906:Antineoplastic Agents, Alkylating; D007166:Immunosuppressive Agents; D015251:Epirubicin; D003520:Cyclophosphamide; D005472:Fluorouracil