Influence of water soluble additives and HPMCP on drug release from Surelease-coated pellets containing tamsulosin hydrochloride.
The objective of this study was to investigate the influence of various water-soluble additives and HPMCP as an enteric polymer into Surelease for the developement of oral controlled release system containg tamsulosin hydrochloride. The drug loaded pellets were coated with only Surelease or Surelease containing HPMC, PEG 4000, mannitol and HPMCP (20% w/w). In case of HPMC and PEG 4000 as additives into Surelease film, the rapid drug release was observed in pH 1.2 while the higher drug release was achieved by adding HPMCP into Surelease as well as by increasing the amount of HPMCP (10, 20, and 30% w/w) in pH 7.2. The incorporation of HPMCP into Surelease showed pH-denpendent drug release due to its pH-dependent nature. Therefore, the incorporation of HPMCP into Surelease based on aqueous coating formulation is an effective way to develop oral controlled release delivery systems containing tamsulosin hydrochloride.
Kim
Min-Soo
MS
National Research Laboratory of Pharmaceutical Technology, College of Pharmacy, Chungnam National University, Daejeon, Korea.
Kim
Jeong-Soo
JS
Kang
Sun-Ho
SH
Yoo
Yeon-Hee
YH
Lee
Sibeum
S
Park
Jeong-Sook
JS
Woo
Jong-Soo
JS
Hwang
Sung-Joo
SJ
D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D004343:Drug Implants; D005079:Excipients / Q000737:chemistry*; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D012995:Solubility; D013449:Sulfonamides / Q000737:chemistry*; D000077409:Tamsulosin; D013997:Time Factors; D014867:Water / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004343:Drug Implants; D005079:Excipients; D013449:Sulfonamides; D014867:Water; C013517:ethyl cellulose; D002482:Cellulose; D008747:Methylcellulose; C053309:hydroxypropyl methylcellulose phthalate; D000077409:Tamsulosin