Molecular epidemiology of rabies in Vietnam.
The present study was done to determine the molecular epidemiology of rabies virus (RV) in Vietnam. The nucleoprotein (N) and glycoprotein (G) genes of RVs were amplified from the brains of ten rabid dogs of Ho Chi Minh City, Vietnam. The nucleotide sequences of these genes were compared with those of other Asian strains to find the possible relationship among them. Phylogenetic analysis revealed that the Asian N gene segregated into three main branches, namely South-East Asia 1 (SEA 1), South-East Asia 2 (SEA 2) and Indian subcontinent (ISC) genotypes. The SEA 1 genotype comprised RVs from Malaysia, Vietnam and Thailand. The SEA 2 genotype contained strains from the Philippines, and the ISC genotype comprised strains from Sri Lanka and India. Phylogenetically G genes of RVs from Vietnam and Thailand were clustered together. Our study suggests that Vietnamese and Thai RVs are closely related and might have originated from a common ancestor.
Yamagata
Junpei
J
Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, Oita University, Yufu, Oita, Japan.
Ahmed
Kamruddin
K
Khawplod
Pakamatz
P
Mannen
Kazuaki
K
Xuyen
Dinh Kim
DK
Loi
Huynh Huu
HH
Dung
Nguyen Van
NV
Nishizono
Akira
A
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D004283:Dog Diseases / Q000453:epidemiology* / Q000821:virology; D004285:Dogs; D005814:Genes, Viral; D005838:Genotype; D006023:Glycoproteins / Q000235:genetics; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D019590:Nucleocapsid Proteins / Q000235:genetics; D010802:Phylogeny; D011818:Rabies / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D011820:Rabies virus / Q000145:classification / Q000235:genetics*; D016415:Sequence Alignment; D013785:Thailand / Q000453:epidemiology; D014744:Vietnam / Q000453:epidemiology; D014759:Viral Envelope Proteins / Q000235:genetics
D000956:Antigens, Viral; D006023:Glycoproteins; D019590:Nucleocapsid Proteins; D014759:Viral Envelope Proteins; C064951:glycoprotein G, Rabies virus