Late-onset neonatal infections caused by group B Streptococcus associated with viral infection.
An association between viral infection and late-onset disease caused by group B Streptococcus (GBS), was systematically looked for in neonates hospitalized for fever during a 3 1/2 year period. Five neonates between 5 to 12.5 months of age presented with meningitis (2 cases) or with septicemia (3 cases) caused by GBS. Viral culture, immunofluorescence, and assay of IFNalpha in blood and cerebrospinal fluid were performed. A viral infection was proved in 4 cases and suspected in 1 case (rash and pharyngitis). We speculate that viral infection may provoke late-onset disease in colonized infants with GBS.
Raymond
Josette
J
Service de Bacteriologie, Hôpital Cochin-Saint Vincent de Paul, University Paris V, 27 rue du Faubourg Saint Jacques, 75679, Paris Cedex 14, France. j.raymond@svp.ap-hop-paris.fr
Armengaud
Jean Baptiste
JB
Lambe
Cécile
C
Tchetchoua
Adelaïde
A
Moulin
Florence
F
Lebon
Pierre
P
Poyart
Claire
C
Gendrel
Dominique
D
D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008581:Meningitis / Q000382:microbiology; D018805:Sepsis / Q000382:microbiology; D013290:Streptococcal Infections / Q000382:microbiology*; D013292:Streptococcus agalactiae / Q000302:isolation & purification*; D014777:Virus Diseases / Q000150:complications*