title: Synthesis and evaluation of hydroquinone derivatives as inhibitors of isocitrate lyase.
abstract: Isocitrate lyase (ICL) is envisaged as an attractive drug target for the development of antimicrobial agents. We have prepared a series of hydroquinone derivatives on the basis of the structure of halisulfates, a naturally occurring inhibitor of ICL. The obtained derivatives were evaluated against ICL of C. albicans. The preliminary structure-activity relationships and the minimal structural requirements for potency were established through structural modifications.
authors: Department of Dental Biomaterials Science, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
authors: Hyeong-Cheol
authors: HC
authors: Yang
authors: Jisu
authors: J
authors: Yu
authors: Ki-Bong
authors: KB
authors: Oh
authors: Dong-Sun
authors: DS
authors: Shin
authors: Won-Jea
authors: WJ
authors: Cho
authors: Jongheon
authors: J
authors: Shin
authors: Sanghee
authors: S
authors: Kim
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006873:Hydroquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors*
chemical_list: D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D006873:Hydroquinones; D007522:Isocitrate Lyase; C031927:hydroquinone