Subchronic heavy metal and alcohol treatment in rats: changes in the somatosensory evoked cortical activity.
Young adult male Wistar rats were treated, by gavage, with 80 or 320 mg/kg Pb2+ (lead acetate), 0.4 or 1.6 mg/kg Hg2+ (mercuric chloride) or both by combining the lower doses. For combination with alcohol, ethanol was added to the rats' drinking water in 5 v/v %. After 12 weeks of treatment, electrophysiological recording was made from the somatosensory cortex in urethane anaesthesia. Evoked potentials obtained by stimulation of the whiskers were recorded. Both metals, and alcohol alone, increased significantly the latency of the evoked response. Alcohol seemed to abolish the effect of Pb, but not of Hg. Fatigue, calculated form the response amplitude, was increased by Pb and Hg treatment and this effect of Hg was reduced by ethanol. Evoked activity and its dynamic characteristics were sensitive to the complex neurotoxic effect induced in the rats and can provide a basis for developing functional markers.
Lukács
Anita
A
Department of Public Health, Faculty of Medicine, University of Szeged, Dom tér 10, H-6720 Szeged, Hungary. lukacsa@puhe.szote.u-szeged.hu
Lengyel
Zsuzsanna
Z
Institóris
L
L
Szabó
Andrea
A
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology; D002492:Central Nervous System Depressants / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D000431:Ethanol / Q000633:toxicity*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects* / Q000502:physiology; D007854:Lead / Q000633:toxicity*; D007855:Lead Poisoning / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D008628:Mercury / Q000633:toxicity*; D008630:Mercury Poisoning / Q000503:physiopathology / Q000517:prevention & control; D020258:Neurotoxicity Syndromes / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology; D014738:Vibrissae / Q000187:drug effects / Q000502:physiology
D002492:Central Nervous System Depressants; D007854:Lead; D000431:Ethanol; D008628:Mercury