Scaffold hopping by "fuzzy" pharmacophores and its application to RNA targets.
Tanrikulu
Yusuf
Y
Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Siesmayerstrasse 70, 60323 Frankfurt am Main, Germany.
Nietert
Manuel
M
Scheffer
Ute
U
Proschak
Ewgenij
E
Grabowski
Kristina
K
Schneider
Petra
P
Weidlich
Markus
M
Karas
Michael
M
Göbel
Michael
M
Schneider
Gisbert
G
D000075:Acepromazine / Q000737:chemistry* / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D019295:Computational Biology / Q000379:methods; D015195:Drug Design; D031541:Fluorescence Resonance Energy Transfer; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D012367:RNA, Viral / Q000737:chemistry* / Q000187:drug effects; D012984:Software; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D054322:tat Gene Products, Human Immunodeficiency Virus / Q000037:antagonists & inhibitors* / Q000737:chemistry
D019380:Anti-HIV Agents; D008024:Ligands; D012367:RNA, Viral; D054322:tat Gene Products, Human Immunodeficiency Virus; D000075:Acepromazine