title: Are ipsilateral breast tumour invasive recurrences in young (< or =40 years) women more aggressive than their primary tumours?
abstract: The characteristics of ipsilateral breast tumour recurrences (IBTRs) relative to those of their primary tumours (PTs) remain scarcely studied. Of 70 young (< or =40 years) premenopausal women with IBTRs, we studied a series of 63 with paired histological data. Median follow-up since IBTR was 10 years. Rates of histological types, grades or hormonal receptors were not significantly different in PTs and in IBTRs. The concordance between IBTRs and their PTs was good for histological types. IBTRs with conserved histological types tended to occur more locally, but not significantly sooner than others. These IBTRs had good concordance for hormone receptors. In discordant cases there were as many losses as appearances of the receptors. The concordance was weak for grades, with equivalent numbers of IBTRs graded lower as higher than their PTs. The 10-year overall survival rate was 70%. Neither the conservation of histological type, location, nor of the two combined were associated with deaths. Early (<2 years) IBTRs, tended to be associated with poorer survival (HR=2.24 (0.92-5.41); P=0.08). IBTRs did not display features of higher aggressiveness than PTs. Neither clinical nor histological definition of a true recurrence could be established other than the conservation of the histological type.
authors: Department of Pathology, Institut Curie, Paris, France.
authors: B
authors: B
authors: Sigal-Zafrani
authors: M A
authors: MA
authors: Bollet
authors: G
authors: G
authors: Antoni
authors: A
authors: A
authors: Savignoni
authors: A
authors: A
authors: Vincent-Salomon
authors: J-Y
authors: JY
authors: Pierga
authors: R
authors: R
authors: Salmon
authors: X
authors: X
authors: Sastre-Garau
authors: A
authors: A
authors: Fourquet
mesh_terms: D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone