title: Preparation and property screening of the solid inclusion complex of norfloxacin with p-sulfonated calix[4]arene.
abstract: The complexation of norfloxacin (NFLX) by p-sulfonated calix[4]arene (SC4A) in aqueous solution has been studied by fluorescence spectroscopy and 1H NMR spectroscopy. A 1:1 stoichiometry and a 8086 L mol(-1) stability constant of the NFLX-SC4A complex was obtained by spectrofluorometric titrations. The equimolar solid state inclusion complex of NFLX-SC4A was prepared by the co-precipitation method and then characterized by various techniques, including differential scanning calorimetry (DSC), X-ray powder diffractometry (XRD), Fourier-transform infrared analysis (FT-IR) and scanning electron microscopy (SEM). The experimental results of these chemical property screenings confirmed that NFLX and SC4A can form a stable host-guest complex in the solid state, and SC4A appears to function as a complexing and solubilizing agent for NFLX.
authors: School of Chemistry & Materials Science, Anhui Key Laboratory of Chemo-Biosensing, Anhui Normal University, Wuhu 241000, PR China.
authors: Qin
authors: Q
authors: Lu
authors: Yunyou
authors: Y
authors: Zhou
authors: Junyong
authors: J
authors: Sun
authors: Lian
authors: L
authors: Wu
authors: Huapeng
authors: H
authors: Yu
authors: Hongwei
authors: H
authors: Xu
authors: Lun
authors: L
authors: Wang
mesh_terms: D047250:Calixarenes / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009643:Norfloxacin / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*
chemical_list: D046911:Macromolecular Substances; D010636:Phenols; C511968:p-sulfonatocalix(4)arene; D047250:Calixarenes; D009643:Norfloxacin