[Depression and sleep].
More than 80% of depressive patients have complaints about sleepiness and insomnia. Physiological researches demonstrate changes in sleep architecture and circadian rhythm in depressive patients. These researches suggest the enhancement of arousal function in daytime and nighttime and circadian changes in cholinergic and catecholaminergic neural system. Pharmacological therapy might be selected in considering the mechanism of these neural changes. The research about sleep deprivation therapy may give us the new advances in the further treatment.
Nakajima
Toru
T
Department of Neuropsychiatry, Faculty of Medicine, Kyorin University.
D000928:Antidepressive Agents / Q000627:therapeutic use; D002395:Catecholamines / Q000502:physiology; D002799:Cholinergic Fibers / Q000502:physiology; D003863:Depression / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D012892:Sleep Deprivation; D020178:Sleep Disorders, Circadian Rhythm / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy
D000928:Antidepressive Agents; D002395:Catecholamines; D006993:Hypnotics and Sedatives