Solid-phase based synthesis of jasplakinolide analogs by intramolecular azide-alkyne cycloadditions.
The synthesis of a focused library of jasplakinolide analogs with a 1,2,3-triazole in place of an E-configured double bond is described, featuring the Cu(I) catalyzed azide-alkyne cycloaddition reaction as an efficient macrocyclization tool.
Hu
Tai-Shan
TS
Universität Dortmund, Fachbereich Chemie, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
Tannert
René
R
Arndt
Hans-Dieter
HD
Waldmann
Herbert
H
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D047630:Depsipeptides / Q000138:chemical synthesis*; D014230:Triazoles / Q000138:chemical synthesis*
D000480:Alkynes; D001386:Azides; D047630:Depsipeptides; D014230:Triazoles; C057531:jasplakinolide