[Preparation and quality evaluation of Iohexol liposomes].
The liposomes were prepared by reverse-phase evaporation technique. The morphology of the liposomes, the entrapment efficiency and the particle size distribution were evaluated. The CT signals of Iohexol liposomes in rabbits were compared with those of Iohexol injection in rabbits. The entrapment efficiency of Iohexol liposomes was 82.35% +/- 1.82%. The liposmes were spherical or ellipsoidal shape in shape. The mean diameter of the Iohexol liposomes was 207 7 nm. The polydispersity index was 0.355. The Zeta potential was--1.83 mV. The drug was highly entrapped into the liposomes with good reproduction and stability. The in vitro release of Iohexol liposomes was significantly slower than that of Iohexol,and was 98.57% at 24 h. Iohexol liposomes may reduce the dosage, prolong the effective time of the developing agent, and could reduce the side effects of Iohexol on the blood vessels and cerebral nerves.
Zhou
Rongli
R
School of Phamacy, Shandong University, Jinan 250012, China.
Zhu
Xiali
X
Hung
Guihua
G
Zhang
Na
N
Zhang
Bingjie
B
D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D007472:Iohexol / Q000138:chemical synthesis* / Q000737:chemistry; D008081:Liposomes / Q000008:administration & dosage / Q000138:chemical synthesis*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011817:Rabbits; D011897:Random Allocation
D003287:Contrast Media; D004337:Drug Carriers; D008081:Liposomes; D007472:Iohexol