Cardiac and respiratory self-gated cine MRI in the mouse: comparison between radial and rectilinear techniques at 7T.
ECG-gated cardiac MRI in the mouse is hindered by many technical difficulties in ECG signal recording inside high magnetic field scanners. The present study proposes a robust rectilinear method of acquiring cardiac and respiratory self-gated cine images in mouse hearts. In this approach, a motion-synchronization MR signal is collected in the center of k-space simultaneously with imaging data in each readout of a nontriggered rectilinear acquisition. This signal is then used for both cardiac and respiratory retrospective gating before cine image reconstruction. The value of this approach for overcoming ECG-gating failure was demonstrated by performing cardiac imaging in eight mice with myocardial infarction. Comparison with an auto-gated radial k-space sampling technique, previously reported for cardiac applications in the mouse, found the rectilinear strategy more robust, thanks to a more reliable self-gating signal, while the radial strategy was less sensitive to motion and flow artifacts.
Hiba
Bassem
B
ANIMAGE, Rhône-Alpes Genopole, Université Claude Bernard Lyon1, Lyon, France. bassem.hiba@cermep.fr
Richard
Nathalie
N
Thibault
Hélène
H
Janier
Marc
M
D000818:Animals; D004562:Electrocardiography; D006321:Heart / Q000502:physiology*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D012143:Respiratory Physiological Phenomena