title: Detection of chemical weapon agents and simulants using chemical ionization reaction time-of-flight mass spectrometry.
abstract: Chemical ionization reaction time-of-flight mass spectrometry (CIR-TOF-MS) has been used for the analysis of prepared mixtures of chemical weapon agents (CWAs) sarin and sulfur mustard. Detection of the CWA simulants 2-chloroethyl ethyl sulfide, triethyl phosphate, and dimethyl methyl phosphonate has also been investigated. Chemical ionization of all the agents and simulants was shown to be possible using the CIR-TOF-MS technique with a variety of reagent ions, and the sensitivity was optimized by variation of instrument parameters. The ionization process was found to be largely unaffected by sample humidity levels, demonstrating the potential suitability of the method to a range of environmental conditions, including the analysis of CWAs in air and in the breath of exposed individuals.
authors: Department of Chemistry, University of Leicester, Leicester, UK.
authors: Rebecca L
authors: RL
authors: Cordell
authors: Kerry A
authors: KA
authors: Willis
authors: Kevin P
authors: KP
authors: Wyche
authors: Robert S
authors: RS
authors: Blake
authors: Andrew M
authors: AM
authors: Ellis
authors: Paul S
authors: PS
authors: Monks
mesh_terms: D001944:Breath Tests; D002138:Calibration; D004784:Environmental Monitoring / Q000295:instrumentation / Q000379:methods; D006813:Humidity; D015394:Molecular Structure; D009151:Mustard Gas / Q000031:analogs & derivatives* / Q000032:analysis*; D010755:Organophosphates / Q000032:analysis*; D009943:Organophosphorus Compounds / Q000032:analysis*; D015203:Reproducibility of Results; D012524:Sarin / Q000032:analysis*; D012680:Sensitivity and Specificity; D053719:Tandem Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D013997:Time Factors
chemical_list: D010755:Organophosphates; D009943:Organophosphorus Compounds; C031116:dimethyl methylphosphonate; C031278:2-chloroethyl ethyl sulfide; D012524:Sarin; C009549:triethyl phosphate; D009151:Mustard Gas