title: Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils.
abstract: We examined the efficacy of auraptene (AUR), an antioxidant agent of a citrus coumarin derivative, for suppressing gastric inflammation introduced by Helicobacter pylori (Hp) infection in Mongolian gerbils (MGs). Hp-infected MGs were placed on diets containing 100 or 500 ppm AUR for 7 weeks. Real-time PCR was used to estimate the Hp population in glandular stomach lesions, and a histological assessment of inflammation was performed. At a dose of 500 ppm, AUR reduced the Hp population to 21.9+/-12.0% of the control group (p<0.05). However, no apparent differences were seen in hematoxylin and eosin sections between AUR-administered and control groups. We conclude that dietary supplementation with 500 ppm of AUR suppresses Hp colonization, but does not reduce gastric inflammation.
authors: Second Department of Pathology, Wakayama Medical University, Kimiidera, Wakayama, Japan.
authors: Koichi
authors: K
authors: Takeda
authors: Hirotoshi
authors: H
authors: Utsunomiya
authors: Seiji
authors: S
authors: Kakiuchi
authors: Yoshiharu
authors: Y
authors: Okuno
authors: Koji
authors: K
authors: Oda
authors: Ken-ichi
authors: K
authors: Inada
authors: Yutaka
authors: Y
authors: Tsutsumi
authors: Takuji
authors: T
authors: Tanaka
authors: Kennichi
authors: K
authors: Kakudo
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001835:Body Weight / Q000187:drug effects; D002957:Citrus / Q000737:chemistry*; D003374:Coumarins / Q000494:pharmacology*; D005849:Gerbillinae / Q000276:immunology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000502:physiology; D008297:Male; D050296:Microbial Viability; D013272:Stomach Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial; D003374:Coumarins; C105832:aurapten