title: Transcriptional activator TonE-binding protein in cellular protection and differentiation.
abstract: The TonE-binding protein (TonEBP) is a transcriptional activator in the Rel family that includes NFkappaB and NFAT. TonEBP is critical for the development and function of the renal medulla, which is a major regulator of water homeostasis. TonEBP is also implicated in diabetic nephropathy and inflammation. Established methods for biochemical and histochemical detection and functional analysis of TonEBP, including identification of novel TonEBP target genes, are described for those who are interested in investigating function and regulation of TonEBP.
authors: Department of Medicine, University of Maryland, Baltimore, Maryland, USA.
authors: Jeong Ah
authors: JA
authors: Kim
authors: Un Sil
authors: US
authors: Jeon
authors: Min Seong
authors: MS
authors: Kwon
authors: Sun Woo
authors: SW
authors: Lim
authors: H Moo
authors: HM
authors: Kwon
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D024202:Electrophoretic Mobility Shift Assay; D006801:Humans; D006982:Hypertonic Solutions / Q000494:pharmacology; D007679:Kidney Medulla / Q000502:physiology; D008969:Molecular Sequence Data; D050778:NFATC Transcription Factors / Q000032:analysis / Q000276:immunology / Q000502:physiology*; D034622:RNA Interference
chemical_list: D006982:Hypertonic Solutions; D050778:NFATC Transcription Factors