Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes.
The synthesis of three acetylene functionalized BODIPY dyes is described. These dyes are used to fluorescently modify an azido functionalized epoxomicin analogue employing the Huisgen 1,3-dipolar cycloaddition, resulting in a panel of fluorescent epoxomicin derived proteasome probes.
Verdoes
Martijn
M
Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
Hillaert
Ulrik
U
Florea
Bogdan I
BI
Sae-Heng
Myra
M
Risseeuw
Martijn D P
MD
Filippov
Dmitri V
DV
van der Marel
Gijsbert A
GA
Overkleeft
Herman S
HS
D000480:Alkynes / Q000737:chemistry*; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002460:Cell Line; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry; D046988:Proteasome Endopeptidase Complex / Q000032:analysis* / Q000737:chemistry
C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000480:Alkynes; D001896:Boron Compounds; D005456:Fluorescent Dyes; D009842:Oligopeptides; D046988:Proteasome Endopeptidase Complex; C078846:epoxomicin