Ring chromosome 12 and severe oligospermia: a case report.
OBJECTIVE
To describe an unusual presentation of ring chromosome 12, which manifested as severe azoospermia, resulting in male infertility.


METHODS
Case report.


METHODS
In vitro fertilization center at a tertiary care hospital.


METHODS
A 27-year-old man diagnosed with unexplained azoospermia and ring chromosome 12 abnormality during a workup for primary infertility.


METHODS
In vitro fertilization with preimplantation genetic diagnosis.


METHODS
To confirm the importance of obtaining karyotypes in individuals with severe oligospermia.


RESULTS
Full-term pregnancy after IVF using donor sperm.


CONCLUSIONS
Severe oligospermia and male infertility should be included in the spectrum of findings found in ring chromosome 12.
Martin
J Ryan
JR
Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.
Wold
Anne
A
Taylor
Hugh S
HS
D000328:Adult; D053713:Azoospermia / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007316:Insemination, Artificial, Heterologous; D007859:Learning Disabilities / Q000235:genetics; D008297:Male; D008831:Microcephaly / Q000235:genetics; D011247:Pregnancy; D019836:Preimplantation Diagnosis; D012303:Ring Chromosomes