Continuous glucose monitoring in children with type 1 diabetes.
OBJECTIVE
To examine the feasibility of daily use of a continuous glucose monitor, the FreeStyle Navigator Continuous Glucose Monitoring System ("Navigator"), in children with type 1 diabetes (T1D).


METHODS
After a masked Navigator was used for 4 to 7 days to establish a baseline level of glycemic control, 30 insulin pump users with T1D (average age 11.2 years) were asked to use the Navigator daily for 13 weeks.


RESULTS
Subjects averaged 149 h/wk of Navigator use during the first 4 weeks, which decreased slightly to 134 h/wk during weeks 9 to 13 (P = .006). Mean hemoglobin A1c improved from 7.1% at baseline to 6.8% at 13 weeks (P = .02), and the percentage of glucose values between 71 and 180 mg/dL increased from 52% to 60% (P = .01). Subjects and parents reported high satisfaction with the Navigator on the Continuous Glucose Monitor Satisfaction Scale. Two subjects had severe skin reactions related to sensor mount adhesive.


CONCLUSIONS
This study indicates that incorporating real-time continuous glucose monitoring into the daily treatment of children with T1D is feasible. The results provide a compelling rationale for conducting a randomized trial of daily use of a continuous glucose monitor in children with T1D.
Buckingham
Bruce
B
Beck
Roy W
RW
Tamborlane
William V
WV
Xing
Dongyuan
D
Kollman
Craig
C
Fiallo-Scharer
Rosanna
R
Mauras
Nelly
N
Ruedy
Katrina J
KJ
Tansey
Michael
M
Weinzimer
Stuart A
SA
Wysocki
Tim
T
D000293:Adolescent; D015190:Blood Glucose Self-Monitoring / Q000009:adverse effects / Q000295:instrumentation; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000628:therapy; D005240:Feasibility Studies; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007332:Insulin Infusion Systems; D008297:Male; D018670:Monitoring, Ambulatory / Q000009:adverse effects / Q000295:instrumentation; D017060:Patient Satisfaction; D010865:Pilot Projects
D006442:Glycated Hemoglobin