title: t(6;14)(q15;q32) in a patient with CD5+CD10+ diffuse large B-cell lymphoma.
abstract: A 68-year-old man presented with systemic lymph node swelling. A biopsy specimen taken from the right cervical lymph node showed that the normal architecture was replaced by a diffuse proliferation of large lymphoid cells with large atypical nuclei. Immunohistochemical analysis showed that the atypical lymphoid cells were positive for CD5, CD10, CD20, CD79a, and Bcl2, and negative for CD3 and cyclin D1. A diagnosis of diffuse large B-cell lymphoma was made. Karyotypic findings included add(5)(q13), del(6)(q13), add(17)(p11), add(19)(p11), add(19)(p13), and t(6;14)(q15;q32). The serum lactate dehydrogenase level and indirect bilirubin level were slightly elevated. Elliptocytosis was observed in the peripheral blood, and a diagnosis of hereditary spherocytosis was made from the family history. Regarding CD5+CD10+ diffuse large B-cell lymphoma with a non-random chromosomal translocation of t(6;14)(q15;q32), studies on the mechanism of lymphomagenesis are needed.
authors: Department of Hematology, Kitasato University, Sagamihara-shi, Kanagawa, Japan. mhayama@med.kitasato-u.ac.jp
authors: Miyuki
authors: M
authors: Hayama
authors: Nozomi
authors: N
authors: Niitsu
authors: Masaaki
authors: M
authors: Higashihara
authors: Hirokazu
authors: H
authors: Nakamine
authors: Ikuo
authors: I
authors: Miura
mesh_terms: D000368:Aged; D018956:CD5 Antigens; D002883:Chromosomes, Human, Pair 14; D002896:Chromosomes, Human, Pair 6; D005192:Family Health; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D007621:Karyotyping; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D015260:Neprilysin; D013103:Spherocytosis, Hereditary / Q000175:diagnosis*; D014178:Translocation, Genetic
chemical_list: D018956:CD5 Antigens; D015260:Neprilysin