First phase release coefficient of insulin in subjects with normal glucose tolerance on glucose infusion analyzed by computer simulation.
We report here a mathematical model using computer simulation to solve the phase fractionation coefficient (f) of instantaneous insulin release on glucose infusion. By extensive model testing with the cited parameters obtained from the literature, the values of the factor f were shown to lie in range of 0.93+/-0.02 (mean+/-2S.D., n=15), indicating that the high pulsatile bolus of glucose by i.v. infusion may trigger acute insulin release (AIR) corresponding to a fraction of more than 90% of the stored insulin release in the first phase from the secretory granules of pancreatic beta cells. In addition, the value of the factor f was shown to be independent of both the glucose infusion method and the non-insulin-dependent uptake of glucose.
Huang
Chien-Ning
CN
School of Medicines, Chung-Shan Medical University, 110 Section 1, Chien-Kuo North Road, Taichung, Taiwan.
Chou
Wen-Chih
WC
Lin
Li-Yun
LY
Peng
Chiung-Chi
CC
Chyau
Charng-Cherng
CC
Chen
Kuan-Chou
KC
Peng
Robert Y
RY
D003198:Computer Simulation; D005947:Glucose / Q000008:administration & dosage* / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000378:metabolism*; D008954:Models, Biological
D007328:Insulin; D005947:Glucose