title: C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.
abstract: OBJECTIVE
  C-reactive protein (CRP) gene variation, in particular an rs2794521 variant was recently associated with type 2 diabetes mellitus (T2DM) in Pima Indians.
  
  
  METHODS
  The present investigation was conducted to replicate this previous association, and to further examine the potential association of a set of common CRP gene variants with the prevalence of T2DM in a case-control investigation. A total of 629 T2DM cases (476 Whites, and 153 Blacks), and 579 controls (481 Whites, and 98 Blacks) were examined. Seven CRP variants were evaluated: rs3093059, rs2794521, rs3091244, rs1417938, rs1800947, rs1130864, and rs1205.
  
  
  RESULTS
  Using a marker-by-marker logistic regression analysis, adjusting for age, smoking, gender, and body mass index, we found an association of rs3093059 (recessive: OR, 7.01; 95% CI, 1.16-42.22; p=0.03) with T2DM in the white study population, and an association, albeit not statistically significant, of rs2794521 with T2DM in the Black study population. Moreover, further analysis using a haplotype-based analysis showed no evidence for an association of the haplotypes tested with T2DM.
  
  
  CONCLUSIONS
  Further studies are needed to examine the possible involvement of C-reactive protein gene variation in the pathogenesis of type 2 diabetes mellitus.
authors: Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA. rzee@rics.bwh.harvard.edu
authors: Robert Y L
authors: RY
authors: Zee
authors: Soren
authors: S
authors: Germer
authors: Abraham
authors: A
authors: Thomas
authors: Annaswammy
authors: A
authors: Raji
authors: Brian
authors: B
authors: Rhees
authors: Paul M
authors: PM
authors: Ridker
authors: Klaus
authors: K
authors: Lindpaintner
authors: Gordon H
authors: GH
authors: Williams
authors: David M
authors: DM
authors: Nathan
authors: Mitchell
authors: M
authors: Martin
mesh_terms: D001741:Black or African American; D000368:Aged; D002097:C-Reactive Protein / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People
chemical_list: D002097:C-Reactive Protein