5-HT7 receptor ligands: recent developments and potential therapeutic applications.
The 5-HT(7) receptors (5-HT(7)Rs) are the most recent classified members of the serotonin family. Characterized in 1993, they belong to the G protein-coupled receptor family. Since their discovery, they have been the subject of intense research due to their widespread distribution in the brain, suggestive of multiple central roles. The focus of this review is to discuss the literature concerning recent advances on 5-HT(7)Rs and their ligands.
Pittalà
Valeria
V
Dipartimento di Scienze Farmaceutiche. Facoltà di Farmacia, Università di Catania, Viale A. Doria 6, 95125 Catania, Italy. vpittala@unict.it
Salerno
Loredana
L
Modica
Maria
M
Siracusa
Maria Angela
MA
Romeo
Giuseppe
G
D000818:Animals; D006801:Humans; D008024:Ligands; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D018490:Serotonin Agents / Q000378:metabolism / Q000494:pharmacology*
D008024:Ligands; D011985:Receptors, Serotonin; D018490:Serotonin Agents; C104425:serotonin 7 receptor