title: Unconventional methyl galactan synthesized via the thexyldimethylsilyl intermediate: preparation, characterization, and properties.
abstract: Reaction of a beta-(1 --> 4) linked galactan with TDMS chloride followed by methylation and desilylation yields methyl galactans with unconventional functionalization patterns. The products were characterized via FTIR and NMR of the intact polymer and by CE after controlled depolymerization. A TDMS-derivatized methyl galactan contains differently methylated secondary hydroxyl groups. SEC and analytical ultracentrifugation showed a consistent decrease in the molecular weight after the consecutive reaction steps. Biological studies revealed that the methyl galactans are less active in complement fixation assays as compared with a 3-O-methyl galactan-enriched polysaccharide fraction isolated from Acanthus ebracteatus.
authors: Center of Excellence for Polysaccharide Research, Friedrich Schiller University of Jena, Humboldtstrasse 10, Jena, Germany.
authors: Andreas
authors: A
authors: Koschella
authors: Kari
authors: K
authors: Inngjerdingen
authors: Berit S
authors: BS
authors: Paulsen
authors: Gordon A
authors: GA
authors: Morris
authors: Stephen E
authors: SE
authors: Harding
authors: Thomas
authors: T
authors: Heinze
mesh_terms: D003168:Complement Fixation Tests; D005685:Galactans / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008756:Methylgalactosides / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D014461:Ultracentrifugation
chemical_list: D005685:Galactans; D008756:Methylgalactosides