title: Antifungal activity of a novel chromene dimer.
abstract: The activity on Aspergillus spp. growth and on ochratoxin A production of two novel chromene dimers (3) was evaluated. The results of the bioassays indicate that the chromene dimer 3a inhibited mycelia growth by approximately 50% (EC(50)) at 140.1 micromol L(-1) for A. niger, 384.2 micromol L(-1) for A. carbonarius, 69.1 micromol L(-1) for A. alliaceus and 559.1 micromol L(-1) for A. ochraceus. When applied at concentrations of 2 mmol L(-1), 3a totally inhibited the growth of all Aspergillus spp. tested. Furthermore, ochratoxin A production by A. alliaceus was reduced by about 94% with a 200 micromol L(-1) solution of this compound. A moderate inhibitory effect was observed for the analogous structure 3b on ochratoxin A production but not in mycelia growth. No inhibition was registered for compounds 2a and 2b, used as synthetic precursors of the dimeric species 3.
authors: IBB-Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
authors: L
authors: L
authors: Abrunhosa
authors: M
authors: M
authors: Costa
authors: F
authors: F
authors: Areias
authors: A
authors: A
authors: Venâncio
authors: F
authors: F
authors: Proença
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D019281:Dimerization; D009793:Ochratoxins / Q000096:biosynthesis
chemical_list: D000935:Antifungal Agents; D001578:Benzopyrans; D009793:Ochratoxins; C025589:ochratoxin A