Serial whole-brain N-acetylaspartate concentration in healthy young adults.
Although the concentration of N-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over the 1-2 year periods of typical clinical trials, the whole-brain NAA concentration was measured longitudinally, over 4 years, in a cohort of healthy young adults. No significant change (adjusted for both sex and age) was measured either interpersonally or intrapersonally over the entire duration of the study.
Rigotti
D J
DJ
Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
Inglese
M
M
Babb
J S
JS
Rovaris
M
M
Benedetti
B
B
Filippi
M
M
Grossman
R I
RI
Gonen
O
O
D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011522:Protons; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate