Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils.
We examined the efficacy of auraptene (AUR), an antioxidant agent of a citrus coumarin derivative, for suppressing gastric inflammation introduced by Helicobacter pylori (Hp) infection in Mongolian gerbils (MGs). Hp-infected MGs were placed on diets containing 100 or 500 ppm AUR for 7 weeks. Real-time PCR was used to estimate the Hp population in glandular stomach lesions, and a histological assessment of inflammation was performed. At a dose of 500 ppm, AUR reduced the Hp population to 21.9+/-12.0% of the control group (p<0.05). However, no apparent differences were seen in hematoxylin and eosin sections between AUR-administered and control groups. We conclude that dietary supplementation with 500 ppm of AUR suppresses Hp colonization, but does not reduce gastric inflammation.
Takeda
Koichi
K
Second Department of Pathology, Wakayama Medical University, Kimiidera, Wakayama, Japan.
Utsunomiya
Hirotoshi
H
Kakiuchi
Seiji
S
Okuno
Yoshiharu
Y
Oda
Koji
K
Inada
Ken-ichi
K
Tsutsumi
Yutaka
Y
Tanaka
Takuji
T
Kakudo
Kennichi
K
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001835:Body Weight / Q000187:drug effects; D002957:Citrus / Q000737:chemistry*; D003374:Coumarins / Q000494:pharmacology*; D005849:Gerbillinae / Q000276:immunology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000502:physiology; D008297:Male; D050296:Microbial Viability; D013272:Stomach Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
D000907:Antibodies, Bacterial; D003374:Coumarins; C105832:aurapten