Boron neutron capture therapy in cancer: past, present and future.
Undifferentiated thyroid cancer (UTC) is a very aggressive tumor with no effective treatment, since it lacks iodine uptake and does not respond to radio or chemotherapy. The prognosis of these patients is bad, due to the rapid growth of the tumor and the early development of metastasis. Boron neutron capture therapy (BNCT) is based on the selective uptake of certain boron non-radioactive compounds by a tumor, and the subsequent irradiation of the area with an appropriate neutron beam. 10B is then activated to 11B, which will immediately decay releasing alpha particles and 7Li, of high linear energy transfer (LET) and limited reach. Clinical trials are being performed in patients with glioblastoma multiforme and melanoma. We have explored its possible application to UTC. Our results demonstrated that a cell line of human UTC has a selective uptake of borophenylalanine (BPA) both in vitro and after transplantation to nude mice. Treatment of mice by BNCT led to a complete control of growth and cure of 100% of the animals. Moreover dogs with spontaneous UTC also have a selective uptake of BPA. At the present we are studying the biodistribution of BPA in patients with UTC before its application in humans.
Pisarev
Mario A
MA
Division of Nuclear Biochemistry, Department of Radiobiology, National Atomic Energy Commission, Buenos Aires, Argentina. pisarev@cnea.gov.ar
Dagrosa
Maria Alejandra
MA
Juvenal
Guilermo J
GJ
D000818:Animals; D001896:Boron Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods / Q000639:trends*; D045744:Cell Line, Tumor; D003905:Deuteroporphyrins / Q000627:therapeutic use; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D000098851:Carboranes
D001896:Boron Compounds; D003905:Deuteroporphyrins; D010649:Phenylalanine; D011838:Radiation-Sensitizing Agents; C080251:2,4-(alpha,beta-dihydroxyethyl)deuteroporphyrin IX tetrakiscarborane carboxylate ester; D000098851:Carboranes; C033685:4-boronophenylalanine