title: [Ion channels and tumor].
abstract: This review illuminates the current approaches of ion channels and tumor. Potassium, calcium, chloride channnels and others are abnormally expressed in the membrane of tumor cells. They are crucial for tumor development and growth. By the regulation of membrane voltage, cell cycle, cell volume, Ca2+ signaling and cytosolic pH, they can adjust the cell proliferation and apoptosis. With further study, ion channels will become a new target for cancer therapy and diagnosis.
authors: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
authors: Yong-Sheng
authors: YS
authors: Jia
authors: Xiao-Li
authors: XL
authors: Wei
authors: Jie
authors: J
authors: Zhao
authors: Jian-Quan
authors: JQ
authors: Zheng
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D049109:Cell Proliferation; D002712:Chlorides / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism
chemical_list: D002712:Chlorides; D007473:Ion Channels; D011188:Potassium; D002118:Calcium