title: Analysis of the endothelial nitric oxide synthase gene as a modifier of the cerebral response to ischemia.
abstract: We studied the endothelial nitric oxide synthase (eNOS or NOS-3) gene as a potential modifier of the cerebral response to ischemia by investigating the association of two common polymorphisms with ischemic stroke volume. We genotyped an intronic variable number tandem repeat and a single nucleotide polymorphism, G894T, in 132 patients with nonlacunar ischemic strokes in whom clinical data and stroke lesion volume were recorded. Our results show that all genotypes are in Hardy-Weinberg equilibrium. After adjustment of covariates, neither of the NOS-3 polymorphisms showed significant differences comparing the genotypes and mean stroke volume (analysis of variance). Our results do not suggest a major gene effect of the NOS-3 gene as a modifier of the cerebral response to ischemia.
authors: New Jersey Neuroscience Institute/JFK Hospital, Edison, New Jersey, USA.
authors: Ana Virginia
authors: AV
authors: Dutra
authors: Hsiu-Fen
authors: HF
authors: Lin
authors: Suh-Hang Hank
authors: SH
authors: Juo
authors: Melanie
authors: M
authors: Boyadjis
authors: Michael
authors: M
authors: Moussouttas
authors: P Leema
authors: PL
authors: Reddy
authors: Raji Paul
authors: RP
authors: Grewal