Use of [123I]-2-iodo-L-phenylalanine as a tumor imaging agent in two dogs with synovial cell sarcoma.
[123I]-iodo-L-phenylalanine was successfully evaluated for gamma camera imaging in vivo in tumor-bearing athymic mice and in humans with brain tumors. Here, we report the use of this tracer in two dogs with synovial cell sarcoma of the tarsus. [123I]-iodo-L-phenylalanine was quantitatively prepared as a kit formulation using the Cu(1+) +-assisted nucleophilic exchange. Rapid [123I]-2-iodo-L-phenylalanine tumor accumulation was observed with good tumor to background contrast and rapid clearance in these two dogs. This radiopharmaceutical is a promising alternative tumor tracer to overcome the known limitations of 18F-fluorodeoxyglucose and, when labelled with radioiodine-131, has the potential to be used for therapeutic purposes.
Peremans
K
K
Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium. Kathelijne.Peremans@UGent.be
Kersemans
V
V
Liuti
T
T
Vandermeulen
E
E
Cornelissen
B
B
Gielen
I
I
De Spiegeleer
B
B
Mertens
J
J
Burvenich
C
C
Slegers
G
G
D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000000981:diagnostic imaging*; D004285:Dogs; D005260:Female; D005360:Fibula / Q000000981:diagnostic imaging; D007457:Iodine Radioisotopes; D008297:Male; D011859:Radiography; D019275:Radiopharmaceuticals; D013584:Sarcoma, Synovial / Q000000981:diagnostic imaging / Q000662:veterinary*; D013977:Tibia / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon / Q000662:veterinary
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals