Evolution of immunoglobulin and mannose binding protein levels after renal transplantation: association with infectious complications.
Hypogammaglobulinemia (hypo-Ig) and low mannose binding protein (MBP) levels might be involved in the infectious risk in renal transplantation. In 152 kidney transplant recipients treated with calcineurin inhibitors (CNI) and mycophenolate mofetil (MMF), during the first year, we prospectively recorded the incidence of hypogammaglobulinemia, and low MBP levels. Their influence on infectious complications was evaluated in 92 patients at 3 and 12 months (T3 and T12). The proportion of deficiency increased significantly: hypo-IgG: 6% (T0), 45% (T3), and 30% (T12) (P < 0.001); hypo-MBP: 5%, 11%, and 12% (P = 0.035). Hypo-IgG at T3 was not associated with an increased incidence of first-year infections. A significantly higher proportion of patients with combined hypogammaglobulinemia [IgG+ (IgA and/or IgM)] at T3 and with isolated hypo-IgG at T0 developed infections until T3 compared with patients free of these deficits (P < 0.05). Low MBP levels at T3 were associated with more sepsis and viral infections. Hypogammaglobulinemia is frequent during the first year after renal transplantation in patients treated with a CNI and MMF. Hypo-IgG at T0 and combined Igs deficts at T3 were associated with more infections. MBP deficiency might emerge as an important determinant of the post-transplant infectious risk.
Broeders
Emine Nilufer
EN
Department of Nephrology, Hospital Erasme, Route de Lennik, Brussels, Belgium. ebroeder@ulb.ac.be
Wissing
Karl Martin
KM
Hazzan
Marc
M
Ghisdal
Lidia
L
Hoang
Anh-Dung
AD
Noel
Christian
C
Mascart
Françoise
F
Abramowicz
Daniel
D
D000361:Agammaglobulinemia / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D015994:Incidence; D007239:Infections / Q000097:blood / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors
D015415:Biomarkers; D007136:Immunoglobulins; D037601:Mannose-Binding Lectin