Periodontitis as a component of hyperinflammation: treating periodontitis in obese diabetic patients.
Increasing evidence points to periodontal disease as a significant risk factor in the etiology of other diseases with inflammatory components, such as cardiovascular disease and type 2 diabetes mellitus. Thus, it may be possible to reduce the risk for other diseases with an inflammatory component by maintaining a healthy periodontium. In addition to plaque and calculus, other factors such as diet, body weight, lifestyle, and environmental stress complicate the maintenance of a healthy periodontium. It is becoming more important for the general dentist to address these additional risk factors in addition to providing conventional treatment for periodontal disease. This review addresses a multifactorial approach to the treatment of periodontal disease and suggests that the "focal theory" of infection may still be relevant for oral inflammation.
Johnson
Roger B
RB
Department of Periodontics & Preventive Sciences, University of Mississippi Medical Center, Jackson, Mississippi, USA.
D017742:Dental Care for Chronically Ill; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D005491:Focal Infection, Dental / Q000150:complications* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D010518:Periodontitis / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha