Greenland sledge dogs (Canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail.
We assessed the relationship between exposure to organohalogen polluted minke whale (Balaenoptera acutorostrata) blubber and liver morphology and function in a generational controlled study of 28 Greenland sledge dogs (Canis familiaris). The prevalence of portal fibrosis, mild bile duct hyperplasia, and vascular leukocyte infiltrations was significantly higher in the exposed group (all Chi-square: p<0.05). In case of granulomas, the frequency was significantly highest in the bitches (P generation) while the prevalence of portal fibrosis was highest in the F generation (pups) (both Chi-square: p<0.05). No significant difference between exposed and controls was found for bile acid, ALAT, and ALKP, while ASAT and LDH were significantly highest in the control group (both ANOVA: p<0.05). We therefore suggest that a daily intake of 50-200g environmentally organohalogen polluted minke whale blubber can cause liver lesions in Greenland sledge dogs. It is reasonable to infer that other apex predators such as polar bears (Ursus maritimus) and humans may suffer from similar impacts.
Sonne
Christian
C
Section for Contaminants, Effects and Marine Mammals, Department of Arctic Environment, National Environmental Research Institute, University of Aarhus, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark. csh@dmu.dk
Leifsson
Pall S
PS
Dietz
Rune
R
Kirkegaard
Maja
M
Jensen
Asger L
AL
Shahmiri
Soheila
S
Letcher
Robert J
RJ
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004032:Diet; D004285:Dogs / Q000254:growth & development*; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D020387:Food Chain; D006116:Greenland; D006846:Hydrocarbons, Halogenated / Q000097:blood / Q000633:toxicity*; D008107:Liver Diseases / Q000097:blood / Q000473:pathology
D004785:Environmental Pollutants; D006846:Hydrocarbons, Halogenated