Piezoelectric control of needle-free transdermal drug delivery.
Transdermal drug delivery occurs primarily through hypodermic needle injections, which cause pain, require a trained administrator, and may contribute to the spread of disease. With the growing number of pharmaceutical therapies requiring transdermal delivery, an effective, safe, and simple needle-free alternative is needed. We present and characterize a needle-free jet injector that employs a piezoelectric actuator to accelerate a micron-scale stream of fluid (40-130 microm diameter) to velocities sufficient for skin penetration and drug delivery (50-160 m/s). Existing jet injectors, powered by compressed springs and gases, are not widely used due to painful injections and poor reliability in skin penetration depth and dose. In contrast, our device offers electronic control of the actuator expansion rate, resulting in direct control of jet velocity and thus the potential for more precise injections. We apply a simple fluid-dynamic model to predict the device response to actuator expansion. Further, we demonstrate that injection parameters including expelled volume, jet pressure, and penetration depth in soft materials vary with actuator expansion rate, but are highly coupled. Finally, we discuss how electronically-controlled jet injectors may enable the decoupling of injection parameters such as penetration depth and dose, improving the reliability of needle-free transdermal drug delivery.
Stachowiak
Jeanne C
JC
University of California, Berkeley, Department of Mechanical Engineering, Berkeley, CA 94720, USA.
von Muhlen
Marcio G
MG
Li
Thomas H
TH
Jalilian
Laleh
L
Parekh
Sapun H
SH
Fletcher
Daniel A
DA
D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D018274:Electroporation / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D007277:Injections, Jet; D008954:Models, Biological; D012867:Skin / Q000378:metabolism*