Individual dose response of insulin resistance to estrogen therapy.
OBJECTIVE
To determined the dose response of insulin resistance (IR) to estrogen in individual patients.


METHODS
Eighteen subjects meeting inclusion criteria were enrolled, and 9 completed the study. Each subject was treated for 3 months with 0.3, 0.625 and 1.25 mg of conjugated equine estrogens (CEE) in random order, for a total of 9 months of treatment. Fasting serum insulin and glucose levels were obtained.


RESULTS
The fasting glucose/insulin ratio and quantitative insulin-sensitivity check index (QUICKI) were calculated. No significant change was noted in either parameter with any dose of CEE in a single subject.


CONCLUSIONS
This was the first study to examine the dose response of IR to estrogen using paired measurements from individuals. IR does not vary in individuals when doses of estrogen are altered.
Jovanovic
Kevin
K
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8063, USA.
Taylor
Hugh S
HS
D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000494:pharmacology*; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood; D013997:Time Factors
D001786:Blood Glucose; D004967:Estrogens; D004966:Estrogens, Conjugated (USP); D007328:Insulin