title: An avenue to the sordarin core adaptable to analog synthesis.
abstract: We describe a synthesis of ketones 3 (X = O-R or CN; Y = H or alkyl), which are useful building blocks for the preparation of analogs of the potent antifungal agent sordarin, 1. Congeners of 1 constructed from 3 should permit detailed SAR investigations of the terpenoid core of the natural product.
authors: Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.
authors: Huan
authors: H
authors: Liang
authors: Arnaud
authors: A
authors: Schulé
authors: Jean-Pierre
authors: JP
authors: Vors
authors: Marco A
authors: MA
authors: Ciufolini
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D007192:Indenes; D013729:Terpenes; C003329:sordarin