Glucose-6-phosphate dehydrogenase deficiency: another risk factor for necrotizing enterocolitis?
We recently observed several babies in our neonatal intensive care unit (NICU) with necrotizing enterocolitis (NEC) who were subsequently found to have glucose-6-phosphate dehydrogenase (G6PD) deficiency. The aim of this study was to explore the association of NEC and G6PD deficiency. G6PD deficiency was significantly higher (27.8%) in infants with NEC compared with the 5.3% prevalence among NICU admissions (odds ratio = 6.9; 95% confidence interval = 2 to 23.5). G6PD deficiency also was found to be a marker for more severe NEC. G6PD deficiency should be considered a risk factor for NEC.
Schutzman
David L
DL
Division of Neonatology, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA. schutzmand@einstein.edu
Porat
Rachel
R
D020345:Enterocolitis, Necrotizing / Q000453:epidemiology*; D005954:Glucosephosphate Dehydrogenase; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D015999:Multivariate Analysis; D015995:Prevalence; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
D005954:Glucosephosphate Dehydrogenase