Serotonin receptor 1A C(-1019)G polymorphism associated with premenstrual dysphoric disorder.
OBJECTIVE
To assess whether the G allele of the serotonin receptor 1A C(-1019)G polymorphism is associated with premenstrual dysphoric disorder.


METHODS
The study sample comprised 53 women with clinically diagnosed premenstrual dysphoric disorder (age range 27-46 years, mean 37.7 years) and 51 healthy control subjects (age range 22-48 years, mean 36.2 years). The serotonin receptor 1A C(-1019)G polymorphism was genotyped and compared between the two groups.


RESULTS
In contrast to the postulated "high-risk" G/G genotype, there was a marked overrepresentation of the C/C genotype in the premenstrual dysphoric disorder group (P=.034; odds ratio 3.63, 95% confidence interval 1.22-10.78). The presence of at least one C allele was associated with a 2.5-fold increased risk of premenstrual dysphoric disorder (P=.053; odds ratio 2.46, 95% confidence interval 1.03-5.88).


CONCLUSIONS
Our hypothesis that the high-risk G allele is associated with the occurrence of premenstrual dysphoria was not proved in this study. However, due to the increased prevalence of the C variant, we suggest that the C(-1019) allele may contribute to the risk of premenstrual dysphoria.


METHODS
II.
Dhingra
Vandana
V
Academic Unit of Obstetrics and Gynecology, Keele University Medical School, University Hospital of North Staffordshire, United Kingdom.
Magnay
Julia L
JL
O'Brien
P M Shaughn
PM
Chapman
Gail
G
Fryer
Anthony A
AA
Ismail
Khaled M K
KM
D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011293:Premenstrual Syndrome / Q000235:genetics* / Q000523:psychology; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D012307:Risk Factors
D044282:Receptor, Serotonin, 5-HT1A