Indications for pediatric liver transplantation. Data from the Heidelberg pediatric liver transplantation program.
Nowadays liver transplantation is an established treatment for children with end-stage liver disease with very good 1- and 5-year survival. This has been achieved through constant improvement of surgical techniques, new immunosuppressive drugs and clinical management. Indications for liver transplantation in infants and children include acute liver failure (ALF), chronic liver failure with pruritus, complications of cholestasis and failure to thrive. In young children, the most common liver disease leading to transplantation is biliary atresia. Biliary atresia accounts for at least 50 percent of all liver transplants in children and is characterized by the failure of the bile ducts to develop normally and drain bile from the liver. Several models to assess prognosis of liver disease have been developed. In acute liver failure leukocyte count, bilirubin, International Normalized Ratio (INR) and age have a strong correlation with outcome. In chronic liver failure, PELD (Pediatric end-stage liver disease) Score and the occurrence of complications of liver disease are important prognostic tools. Since the start of our own paediatric liver transplantation program at the University of Heidelberg in 2003, already 15 Children between 5 months and 14 years have been transplanted. Indications and outcome of these patients are reviewed in this paper.
Engelmann
G
G
University of Heidelberg, Department of Paediatrics, INF 150, D-69120 Heidelberg, Germany. guido_engelmann@med.uni-heidelberg.de
Schmidt
J
J
Oh
J
J
Lenhartz
H
H
Wenning
D
D
Teufel
U
U
Büchler
M W
MW
Hoffmann
G F
GF
Meyburg
J
J
D000293:Adolescent; D001652:Bile Ducts / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005858:Germany; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D019934:International Normalized Ratio; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000628:therapy; D016031:Liver Transplantation / Q000379:methods*; D011379:Prognosis; D016896:Treatment Outcome
D007166:Immunosuppressive Agents