The integrin-growth factor receptor duet.
Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli originating in the extracellular environment. In this article, we review the role of integrins as molecular switches that modulate GFR activation and specificity. We also examine the reciprocal modulation of integrin functions by GFRs and the mechanisms through which those actions are fine-tuned.
Alam
Naved
N
Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Goel
Hira Lal
HL
Zarif
Matthew J
MJ
Butterfield
Julie E
JE
Perkins
Hillary M
HM
Sansoucy
Brian G
BG
Sawyer
Thomas K
TK
Languino
Lucia R
LR
D000818:Animals; D005544:Forecasting; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008024:Ligands; D008954:Models, Biological; D017978:Receptors, Growth Factor / Q000378:metabolism*
D016023:Integrins; D008024:Ligands; D017978:Receptors, Growth Factor