title: Novel proton acceptor immonium-type coupling reagents: application in solution and solid-phase peptide synthesis.
abstract: A novel proton acceptor coupling reagent shows superiority to those described previously. The oxygen in the carbocation moiety confers more solubility to the reagent. Furthermore, it enhances coupling yields and decreases racemization, allowing the use of 1 equiv of base.
authors: Institute for Research in Biomedicine, Barcelona Science Park, Josep Samitier 1, 08028-Barcelona, Spain. aymanel_faham@hotmail.com
authors: Ayman
authors: A
authors: El-Faham
authors: Fernando
authors: F
authors: Albericio
mesh_terms: D006571:Heterocyclic Compounds / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*; D013997:Time Factors
chemical_list: D006571:Heterocyclic Compounds; D010455:Peptides