title: Shape-based normalization of the corpus callosum for DTI connectivity analysis.
abstract: The continuous medial representation (cm-rep) is an approach that makes it possible to model, normalize, and analyze anatomical structures on the basis of medial geometry. Having recently presented a partial differential equation (PDE)-based approach for 3-D cm-rep modeling [1], here we present an equivalent 2-D approach that involves solving an ordinary differential equation. This paper derives a closed form solution of this equation and shows how Pythagorean hodograph curves can be used to express the solution as a piecewise polynomial function, allowing efficient and robust medial modeling. The utility of the approach in medical image analysis is demonstrated by applying it to the problem of shape-based normalization of the midsagittal section of the corpus callosum. Using diffusion tensor tractography, we show that shape-based normalization aligns subregions of the corpus callosum, defined by connectivity, more accurately than normalization based on volumetric registration. Furthermore, shape-based normalization helps increase the statistical power of group analysis in an experiment where features derived from diffusion tensor tractography are compared between two cohorts. These results suggest that cm-rep is an appropriate tool for normalizing the corpus callosum in white matter studies.
authors: Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA . sunhui@seas.upenn.edu
authors: Hui
authors: H
authors: Sun
authors: Paul A
authors: PA
authors: Yushkevich
authors: Hui
authors: H
authors: Zhang
authors: Philip A
authors: PA
authors: Cook
authors: Jeffrey T
authors: JT
authors: Duda
authors: Tony J
authors: TJ
authors: Simon
authors: James C
authors: JC
authors: Gee
mesh_terms: D061085:Agenesis of Corpus Callosum; D000465:Algorithms; D001185:Artificial Intelligence; D002648:Child; D003198:Computer Simulation; D003337:Corpus Callosum / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008959:Models, Neurological; D015233:Models, Statistical; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique