[Clinicopathologic significance of chromosomal DNA sequence copy number aberrations in patients with colorectal carcinoma].
OBJECTIVE
To analyze the correlation of DNA sequence copy number aberrations (DSCNAs)with clinicopathologic parameters in patients with colorectal cancer(CRC).


METHODS
Comparative genomic hybridization (CGH) method was used in analysis of 73 cases with CRC. Statistical analysis was performed using Stat View statistical software package(5.0).


RESULTS
Loss of 8pl2-pter and gain of 8q23-qter were linked to nodal metastasis, while loss of 18q12-qter and gain of 8q23-qter were associated with distant organ metastasis at diagnosis and (or) recurrence after surgery. Moreover, losses of 8pl2-pter and 18q12-qter and gain of 8q23-qter were associated significantly with unfavorable prognosis. Multivariate analysis revealed that loss of 18q12-qter was an independent prognostic marker.


CONCLUSIONS
Our findings indicate that genetic aberrations detected by CGH may predict outcome in patients with CRC, and may provide useful information for clinical treatment. Comparative genomic hybridization;
Liu
Xiu-Ping
XP
Department of Pathology, Fudan University School of Medicine, Shanghai 200032, China. xpliu1228@fudan.edu.cn
Kawauchi
Shigeto
S
Oga
Atsunori
A
Sasaki
Kohsuke
K
D000368:Aged; D000369:Aged, 80 and over; D002430:Cecal Neoplasms / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D018628:Gene Dosage; D015894:Genome, Human; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009693:Nucleic Acid Hybridization / Q000379:methods; D011379:Prognosis; D012004:Rectal Neoplasms / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm