[Effects of Patrinia scabra bunge macroporous adsorptive resins extracts on erythrocyte immune function in tumor bearing mice].
OBJECTIVE
To study the erythrocyte immuno-regulatory effect of Patrinia scabra Bunge extracts extracted by macroporous adsorptive resins in tumor bearing mice.


METHODS
Patrinia scabra Bunge was extracted by macroporous adsorptive resins, and the amount of polysaccharides and saponins in the extract were determined. Mice bearing S180 tumor were treated with the extract and their survival prolongation rate, erythrocyte rosette formation rates of C3b receptor (ERR-CR), immune complex (ERR-IC) and tumor cell (ERR-TC), as well as the CD35 and CD44s were observed.


RESULTS
Polysaccharide content was 21.4%, saponin 41.8% in the extract. As compared with the model group, the survival rate was increased, the erythrocyte immune function was improved (showed increase of ERR-CR and ERR-TC, decrease of ERR-IC), and the amount of CD35 and CD44s in red blood cell membrane increased in mice after being treated with the extract (P < 0.05 or P < 0.01).


CONCLUSIONS
Extract of Patrinia scabra Bunge extracted by macroporous adsorptive resins can regulate the erythrocyte immune function to a certain extent.
Wang
Xue-xi
XX
Institute of Integrated Traditional Chinese and Western Medicine, Lanzhou University, Lanzhou. wxx0804@126.com
Zhao
Jian-xiong
JX
Cheng
Wei-dong
WD
D000327:Adsorption; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D005260:Female; D008297:Male; D051379:Mice; D032405:Patrinia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D017463:Receptors, Complement 3b / Q000276:immunology; D012117:Resins, Synthetic / Q000737:chemistry; D012397:Rosette Formation; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000276:immunology
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D017463:Receptors, Complement 3b; D012117:Resins, Synthetic