Toxic uveitis caused by pharmacodynamic interactions of Rifabutin and protease inhibitors: a case report.
Toxic reactions (uveitis, arthritis and leucopenia) of Rifabutin at normal doses should always be considered because of pharmacokinetic interactions with other drugs (e.g. the protease inhibitors). This case demonstrates that this kind of uveitis is clinically significant as the diagnosis of uveitis, particularly hypopyon uveitis, in an immunocompromised patient generally mandates extensive systemic diagnostic evaluation, as well as intensive ophthalmic and systemic monitoring and therapy.
Ebraert
H
H
Oogheelkunde, AZ-VUB, Brussel. hebraert@hotmail.com
Salu
P
P
D017088:AIDS-Related Opportunistic Infections / Q000139:chemically induced* / Q000188:drug therapy; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000328:Adult; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy; D011480:Protease Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D017828:Rifabutin / Q000009:adverse effects*; D014605:Uveitis / Q000139:chemically induced*
D011480:Protease Inhibitors; D017828:Rifabutin