Heat-shock protein 65 autoantibodies are differently associated with early atherosclerosis in rheumatoid arthritis and in healthy subjects.
The aim of this study was to examine whether heat-shock protein (HSP)-65 autoantibodies are associated with early atherosclerosis in rheumatoid arthritis (RA). Intima-media thickness (IMT) was measured in the carotid arteries of 100 RA patients and 69 control subjects. The IMT was evaluated on both carotid arteries in the common carotid, bifurcation, and internal arteries. Every patient underwent anti-HSP-65 antibody evaluation. Anti-HSP-65 antibodies were not more prevalent among patients compared with controls. Among controls, patients having "positive" anti-HSP-65 tended to have increased carotid artery IMT compared with "negative" patients, whereas among RA patients the opposite association was noted, and positive patients had significantly decreased carotid bifurcation IMT than negative patients without elevated levels of anti-HSP-65. As opposed to the association with cardiovascular diseases and atherosclerosis of anti-HSPs in the general population, among RA patients anti-HSP-65 cannot be regarded as associated with early atherosclerosis.
Sherer
Yaniv
Y
Department of Medicine 'B' and Center of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
Gerli
Roberto
R
Bocci
Elena Bartoloni
EB
Gilburd
Boris
B
Vaudo
Gaetano
G
Bistoni
Onelia
O
Shoenfeld
Yehuda
Y
D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications / Q000276:immunology; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014463:Ultrasonography; D018834:Chaperonin 60; D024101:Mitochondrial Proteins
D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; D006360:Heat-Shock Proteins; C060293:HSPD1 protein, human; D018834:Chaperonin 60; D024101:Mitochondrial Proteins