title: I/D genetic polymorphism of angiotensin-converting enzyme: pathogenesis evaluation for erectile dysfunction by gene ontology.
abstract: OBJECTIVE
  Angiotensin-converting enzyme (ACE) is the major regulator of mineralocorticoid synthesis and it is in the renin/angiotensin system. Angiotensin-converting enzyme is responsible for several vascular diseases. It also relates to erectile dysfunction. However, in-depth analysis on the effect of genetic I/D polymorphism of ACE has never been performed. The molecular mechanisms for each genotype expression in erectile dysfunction are poorly understood.
  
  
  METHODS
  Gene ontology technique.
  
  
  METHODS
  Chulalongkorn University Hospital, Bangkok, Thailand.
  
  
  METHODS
  Men with erectile dysfunction.
  
  
  METHODS
  In the present study, I have used a new gene ontology technique to predict the molecular function and biological process for the II, ID, and DD genotypes of ACE.
  
  
  METHODS
  Molecular function and biological process.
  
  
  RESULTS
  According to this gene ontology study, it can be shown that the DD genotype lacks molecular function and biological process.
  
  
  CONCLUSIONS
  The lack of carboxypeptidase activity in DD genotype might be the clue for erectile dysfunction pathogenesis.
authors: Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address: wviroj@yahoo.com.
authors: Viroj
authors: V
authors: Wiwanitkit
mesh_terms: D000483:Alleles; D002268:Carboxypeptidases / Q000378:metabolism; D007172:Erectile Dysfunction / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests
chemical_list: D002268:Carboxypeptidases; D007703:Peptidyl-Dipeptidase A