Motor deactivation in the human cortex and basal ganglia.
We used a functional magnetic resonance imaging motor activation paradigm for both hands and functional connectivity analyses to investigate motor deactivation. These analyses revealed ipsilateral (to the task) postcentral gyrus connectivity with the ipsilateral primary motor cortex as well as contralateral cerebellum for both hands. Analyses using default-mode network nodes as seed regions revealed connectivity patterns similar to previous studies of the default network and therefore provide evidence that this network is demonstrable using a synchronized motor activation paradigm. We did not find evidence suggesting that motor deactivation represents modulation of the default mode network. Therefore, motor deactivation is likely a motor-specific process. Finally, we found no evidence of basal ganglia circuit deactivation, which suggests that the two-pathway hypothesis of frontal-subcortical circuit function may be incomplete.
Marchand
William R
WR
Department of Veterans Affairs, VISN 19 MIRECC, and University of Utah, Salt Lake City, UT 84148, USA. william.marchand@va.gov
Lee
James N
JN
Thatcher
John W
JW
Thatcher
Grant W
GW
Jensen
Cody
C
Starr
Jennifer
J
D000328:Adult; D001479:Basal Ganglia / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D004522:Educational Status; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D008959:Models, Neurological; D009043:Motor Activity / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology; D018579:Patient Selection; D011930:Reaction Time / Q000502:physiology*; D012016:Reference Values
D018377:Neurotransmitter Agents