Pleomorphic leiomyosarcoma of the adrenal gland: case report and review of the literature.
Primary adrenal leiomyosarcomas (LMS) are extremely rare mesenchymal tumors. To the best of our knowledge only 12 cases (9 cases of conventional and 2 cases of pleomorphic LMS) have been reported in the literature until the present date. Herein we report a case of pleomorphic LMS in a 47-year-old woman who presented with severe abdominal pain. Computed tomography showed a large heterogeneous left adrenal mass abutting the renal vessels. The adrenal mass was resected and histopathologic examination revealed a highly pleomorphic malignant spindle cell neoplasm diffusely infiltrating the adrenal parenchyma with an immunoprofile consistent with that of a leiomyosarcoma. Clinical management and subsequent follow-up of this patient is presented.
Mohanty
Sambit K
SK
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. mohantys2@upmc.edu
Balani
Jyoti P
JP
Parwani
Anil V
AV
D015746:Abdominal Pain / Q000209:etiology; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D000315:Adrenalectomy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077143:Docetaxel; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000473:pathology; D007890:Leiomyosarcoma / Q000150:complications / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology; D009392:Nephrectomy; D018714:Radiotherapy, Adjuvant; D043823:Taxoids / Q000008:administration & dosage; D013924:Thrombophlebitis / Q000209:etiology; D014594:Uterine Neoplasms / Q000473:pathology; D000093542:Gemcitabine
D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D000093542:Gemcitabine