title: Radiation-induced rhabdomyosarcomatous transformation of a recurrent meningeal haemangiopericytoma.
abstract: A 53-year-old woman presented in 1979 with a posterior fossa meningeal haemangiopericytoma (HPC) for which she underwent surgical resection and post-operative radiotherapy. Repeated tumour recurrences occurred 18 years afterwards which were treated with resections and stereotactic radiotherapy. Surgery for tumour recurrence in 2005 revealed features of rhabdomyosarcomatous transformation. To our knowledge, this is the first reported case of rhabdomyosarcomatous transformation within a HPC which was likely to be radiation-induced, and was associated with relentless disease progression more than 20 years after the initial presentation.
authors: Division of Neurosurgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China. gilberto@hkucc.hku.hk
authors: G Ka Kit
authors: GK
authors: Leung
authors: W Chun Kit
authors: WC
authors: Lee
authors: J M
authors: JM
authors: Nicholls
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000473:pathology / Q000528:radiation effects*; D003131:Combined Modality Therapy; D003388:Cranial Fossa, Posterior / Q000601:surgery; D016371:Cranial Irradiation / Q000009:adverse effects*; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006393:Hemangiopericytoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D016634:Radiosurgery; D018714:Radiotherapy, Adjuvant; D012086:Reoperation; D012208:Rhabdomyosarcoma / Q000473:pathology*; D014057:Tomography, X-Ray Computed