Clinical study on the treatment of premature ejaculation by Uighur medicine gu-jing-mai-si-ha tablet.
OBJECTIVE
To observe the effect of Uighur medicine gu-jing-mai-si-ha tablet (GJMSHT) for treatment of premature ejaculation (PE) and to explore part of its mechanism.


METHODS
The condition of patients was scored by related questionnaire, and the intravaginal ejaculation latency time (IELT) was observed before and after GJMSHT treatment, with the blood levels of nitric oxide (NO) and prostaglandin F2alpha (PGF2alpha) detected in PE patients as well. The results were compared with those in the control group.


RESULTS
After treatment, the scores of PE and IELT, as well as the levels of NO and PGF2alpha, all increased significantly compared to those before treatment in the treated group (P<0.01), while in the control group, all the parameters were insignificantly changed (P>0.05). Therefore, the difference of these parameters between the two groups after treatment all showed statistical significance (P<0.01).


CONCLUSIONS
GJMSHT could treat PE effectively, its mechanism is possibly by strengthening the coordination of the related smooth muscles through increasing the blood levels of NO and PGF2alpha, and the endurance of patients to the cavitary effect of prostatico-urethral pressure, thus postponing the arrival of urgent ejaculatory feeling.
Song
Guo-hong
GH
The 5th Affiliated Hospital of Xinjiang Medical University, Urumuqi, 830011, China.
Halmurat-Upur
Geng
Jin-cheng
JC
Feng
Lian-cheng
LC
Yilihamujiang-shabi
Ma
Chao
C
Liu
Jun
J
D000328:Adult; D015237:Dinoprost / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use*; D004542:Ejaculation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy* / Q000503:physiopathology*; D013607:Tablets
D004365:Drugs, Chinese Herbal; D013607:Tablets; C525736:gu-jing-mai-si-ha; D009569:Nitric Oxide; D015237:Dinoprost