[Physiological function of osteocytes].
Osteocytes produce DMP1 (dentin matrix protein 1), FGF23 (fibroblast growth factor 23) and sclerostin. FGF23 is a phosphate-regulating hormone that links bone to kidney. DMP1 is a matrix protein that is involved in mineralization. Patients with DMP1 mutations exhibit increased FGF23 and hypophosphatemia, suggesting that DMP1 negatively regulates FGF23 in osteocytes. Sclerostin is secreted by osteocytes and negatively regulates osteoblastic function, and its neutralizing antibody is being developed as a new treatment for osteoporosis. A mouse model that enables targeted ablation of osteocytes tells us about the physiologic and pathologic functions of osteocytes in regulating bone remodeling in response to mechanical environment.
Ikeda
Kyoji
K
National Center for Geriatrics and Gerontology, Department of Bone and Joint Disease.
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000096:biosynthesis* / Q000302:isolation & purification / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis* / Q000502:physiology; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000096:biosynthesis* / Q000502:physiology; D005819:Genetic Markers / Q000502:physiology; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D010011:Osteocytes / Q000378:metabolism / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; C513308:Dmp1 protein, mouse; D016326:Extracellular Matrix Proteins; C000717428:Fgf23 protein, mouse; D005819:Genetic Markers; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; C486030:Sost protein, mouse; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23