Neurons skip a beat during fast ripples.
Fast ripples are EEG transients emanating from epileptic foci, but fast-ripple frequencies far exceed maximal neuronal firing rates. In this issue of Neuron, Menendez de la Prida and coworkers propose that out-of-phase firing of a subpopulation of neurons during physiological ripple activity effectively doubles the ripple frequency to produce fast ripples.
Staley
Kevin J
KJ
Neurology Department, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. kstaley@partners.org
D000818:Animals; D004569:Electroencephalography; D004594:Electrophysiology; D004827:Epilepsy / Q000503:physiopathology*; D006624:Hippocampus / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D051381:Rats