title: Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure.
abstract: BACKGROUND
  Although a more favorable neurohormonal balance may contribute to improving symptoms following cardiac resynchronization therapy (CRT), no information is available regarding the effects of CRT on insulin-like growth factor-1 (IGF-1). This study assessed the effects of CRT on IGF-1 levels and their correlation with changes in quality of life and left ventricular (LV) function.
  
  
  RESULTS
  Patients with cardiomyopathy in New York Heart Association class III or IV (n = 18; age 71 +/- 10 years), left ventricular ejection fraction (LVEF) < or = 40% and QRS > or = 130 ms or ventricular dyssynchrony were enrolled in the study and followed up for 6 months. After 3 months, there was an improvement in LVEF (from 29 +/- 7 to 33 +/- 10%, P = 0.0136) and quality of life (from 33 +/- 14 to 13 +/- 12, P = 0.0000) and an increase in IGF-1 levels (from 137 +/- 79 to 175 +/- 111 ng/ml, P = 0.01353). The change in quality of life correlated with changes in IGF-1 levels (P = 0.02) but not with LVEF changes.
  
  
  CONCLUSIONS
  In patients with advanced heart failure, CRT leads to a significant increase in plasma IGF-1 levels within 3 months. This increase is correlated with the improvement in quality of life, whereas the increase in LVEF is not. This finding suggests that IGF-1 may play a role as a mediator in the early phase of symptomatic improvement after CRT.
authors: Department of Cardiology, Sacro Cuore Hospital, don Calabria, Via don A. Sempreboni, Negrar, Verona, Italy. giulio.molon@sacrocuore.it
authors: Giulio
authors: G
authors: Molon
authors: Edoardo
authors: E
authors: Adamo
authors: Gaetano M
authors: GM
authors: De Ferrari
authors: Francesco
authors: F
authors: Accardi
authors: Eros
authors: E
authors: Dalla Vecchia
authors: Luciano
authors: L
authors: Sallusti
authors: Stefano
authors: S
authors: Ciaffoni
authors: Enrico
authors: E
authors: Barbieri
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011788:Quality of Life; D013318:Stroke Volume
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1