Acute basophilic leukaemia: a case report.
Acute basophilic leukaemia is an uncommon form of acute leukaemia, rarely occurring as de novo disease. Due to rarity of the disease, consistent diagnostic criteria for the identification of this entity still remain the topic of discussion. Immunophenotypic profile, electron microscopy and cytogenetic analysis in addition to morphological features, are said to be highly desirable for correct identification of this entity. In set-up like ours, where such facilities are either not available or not in reach of the patients due to financial constraints, morphological features and simple technique like demonstration of metachromasia in blasts with toluidine blue stain remain the most useful diagnostic tool for identification of this rare condition. We present a case of acute basophilic leukaemia with (11q23)-MLL gene rearrangement, in an 18-year-old male with review of literature and discussion of diagnostic criteria.
Kokandakar
H R
HR
Department of Pathology, Govt. Medical College, Aurangabad.
Tembhare
P R
PR
Mamoon
Alfatmi
A
Mulay
V M
VM
Bhople
K S
KS
D000293:Adolescent; D004396:Coloring Agents; D015321:Gene Rearrangement; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D015471:Leukemia, Basophilic, Acute / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics; D013194:Staining and Labeling; D014048:Tolonium Chloride
D004396:Coloring Agents; C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D014048:Tolonium Chloride; D011495:Histone-Lysine N-Methyltransferase