Anti-obesity and hypolipidemic effects of black soybean anthocyanins.
The effect of anthocyanins extracted from black soybean (Glycine max L.) seed coats on body weight, adipose tissue weight, and serum lipids was evaluated in rats fed a high fat diet (HFD). Rats were raised on a normal diet (ND) (based on the AIN-93M diet), HFD (ND supplemented with 16% lard oil), HFD containing 10% black soybean, and HFD containing 0.037% black soybean anthocyanins (equivalent to that in the 10% black soybean diet). Weight gain was significantly lowered in the rats fed HFD plus black soybean anthocyanins compared with the rats fed HFD alone (P < .05) and reversed to the level of the rats fed ND. The black soybean diet also decreased body weight gain compared with the HFD (P < .05). The black soybean anthocyanins-added diet suppressed the HFD-induced weight gain in liver intermediately and tended to decrease the weights of epididymal and perirenal fat pads. The black soybean anthocyanins were also effective in improving the lipid profile. They significantly reduced the levels of serum triglyceride and cholesterol (P < .05), while they markedly increased the high-density lipoprotein-cholesterol concentration, which was decreased in the rats fed HFD (P < .05). These results indicate that the anthocyanins in black soybean seed coats have an anti-obesity effect, which can reverse the effects of HFD on body weight, adipose tissue weight, and serum lipid contents.
Kwon
Sun-Hwa
SH
Department of Food Science and Nutrition, Pusan National University, Geumjeong-gu, Busan, Republic of Korea.
Ahn
In-Sook
IS
Kim
Su-Ok
SO
Kong
Chang-Suk
CS
Chung
Hae-Young
HY
Do
Myoung-Sool
MS
Park
Kun-Young
KY
D000273:Adipose Tissue / Q000033:anatomy & histology; D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D008297:Male; D009765:Obesity / Q000517:prevention & control*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry*; D013025:Glycine max / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
D000872:Anthocyanins; D008076:Cholesterol, HDL; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D014280:Triglycerides; D002784:Cholesterol