Flavonoid glycosides from Prunus armeniaca and the antibacterial activity of a crude extract.
Investigations on the chemical constituents of the fruits of Prunus armeniaca have led to the isolation of two new flavonoid glycosides, 4',5,7-trihydroxy flavone-7-O-[beta-D-mannopyranosyl (1'''-->2")]-beta-D-allopyranoside (1) and 3,4',5,7-tetrahydroxy-3',5'-di-methoxy flavone 3-O-[alpha-L-rhamnopyranosyl (1'''-->6")]-beta-D-galactopyranoside (2), from the butanolic fraction of the fruits. The butanolic extract exhibited antibacterial activity against both Gram positive and Gram negative bacteria. The structures of these compounds were elucidated through spectral studies, including 2D-NMR (COSY, NOESY, J-resolved), HMQC and HMBC experiments.
Rashid
Fahima
F
Department of Chemistry, Faculty of Science, University of Karachi, Karachi, Pakistan.
Ahmed
Rehana
R
Mahmood
Azhar
A
Ahmad
Zaheer
Z
Bibi
Nazia
N
Kazmi
Shahana Urooj
SU
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D027861:Prunus / Q000737:chemistry*
C523768:3,4',5,7-tetrahydroxy-3',5'-di-methoxy flavone 3-O-(alpha-L-rhamnopyranosyl (1'''-6''))-beta-D-galactopyranoside; C523769:4',5,7-trihydroxy flavone-7-O-(beta-D-mannopyranosyl (1'''-2''))-beta-D-allopyranoside; D000900:Anti-Bacterial Agents; D005419:Flavonoids; D006027:Glycosides