The association of tea consumption with ovarian cancer risk: A metaanalysis.
OBJECTIVE
This metaanalysis was undertaken to evaluate the relationship between tea intake and ovarian cancer risk.


METHODS
A systematic literature search up to September 2006 was performed in Medline, Embase, CANCERLIT, and the Cochrane Database. The summary relative risk was calculated. A sensitivity analysis was conducted to test the influence of each single study. Heterogeneity and publication bias were also evaluated.


RESULTS
Two cohort and 7 case-control studies were included. The combined relative risk did not show that tea consumption was associated with a reduced ovarian cancer risk (relative risk, 0.84; 95% confidence interval, 0.66-1.07). When the analyses were stratified into subgroups, there was no evidence that study design substantially influenced the estimate of effects. The sensitivity analysis which means removing one study at a time confirmed the stability of our results.


CONCLUSIONS
Our findings did not support that tea consumption was related to the decreased risk of ovarian cancer.
Zhou
Bo
B
Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Yang
Li
L
Wang
Liansheng
L
Shi
Yanping
Y
Zhu
Huaijun
H
Tang
Naping
N
Wang
Bin
B
D001628:Beverages; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000517:prevention & control*; D012306:Risk; D013662:Tea
D013662:Tea