[Zinc and insulin level in islet cells under various functional state of insular apparatus].
The work is devoted to the study of zinc role in pancreas incretory function. Golden hamster and human pancreatic beta cells were investigated under varions functional state of insular apparatus. An increase of zinc and insulin content in islet beta cells was observed during inhibition of its' secretory activity and decrease of both components content in the cells occurred after intensifying of its' activity. Under pancreatic diabetes zinc and insulin quantities in beta cells were significantly less the norm. The results of comparative investigations confirm the thesis concerning this metal and hormone connection in beta-insulocytes.
Berehova
T V
TV
Hryhorova
N V
NV
Ieshchenko
Iu V
IuV
Bovt
V D
VD
Ieshchenko
V A
VA
D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003920:Diabetes Mellitus / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology; D005508:Food Deprivation; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism; D008647:Mesocricetus; D010862:Pilocarpine / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D015032:Zinc / Q000378:metabolism*
D007328:Insulin; D010862:Pilocarpine; D000496:Alloxan; D011239:Prednisolone; D005947:Glucose; D015032:Zinc; D004837:Epinephrine