1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.
Enantiopure constrained 1-aminocyclopentane-1,2,4-tricarboxylic acids containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carboxylic groups in position two and four cis-oriented to each other and trans with respect to 1-carboxylic group and all cis-oriented carboxylic groups, respectively. A biochemical screening of activity of the above amino acids was investigated on glutamate and 5-HT receptors to find a possible metabotropic agonist, acting on the serotoninergic system.
Gelmi
Maria Luisa
ML
Istituto di Chimica Organica "A. Marchesini", Facoltà di Farmacia, Università di Milano, Via Venezian 21, I-20133 Milano, Italy.
Caputo
Francesco
F
Clerici
Francesca
F
Pellegrino
Sara
S
Giannaccini
Gino
G
Betti
Laura
L
Fabbrini
Laura
L
Schmid
Lara
L
Palego
Lionella
L
Lucacchini
Antonio
A
D000818:Animals; D002478:Cells, Cultured; D003517:Cyclopentanes / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D015394:Molecular Structure; D051381:Rats; D017470:Receptors, Glutamate / Q000187:drug effects / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D013237:Stereoisomerism; D014233:Tricarboxylic Acids / Q000737:chemistry* / Q000494:pharmacology*
C409063:1-aminocyclopentane-1,2,4-tricarboxylic acid; D003517:Cyclopentanes; D017470:Receptors, Glutamate; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D014233:Tricarboxylic Acids