Synthesis and DNA-cleavage properties of metal complexes of 1,4,7,10-tetraazacyclododecane (cyclen) functionalized with a pendant benzocrown ether.
The synthesis and DNA-cleavage properties of a series of novel mononuclear Zn(II), Cu(II), and Co(II) complexes 2 of a crown-ether-functionalized cyclen ligand is described. The Cu complex 2b displayed the highest catalytic activity towards pUC 19 DNA. The effects of reaction time, complex concentration, and pH were investigated, showing that 2b readily and efficiently converts supercoiled (type I ) plasmid DNA to nicked (type II) DNA under physiological conditions (37 degrees, pH 7.4).
Tan
Xin-Yu
XY
Department of Chemistry, Key Laboratory of Green Chemistry and Technology, (Ministry of Education), Sichuan University, Chengdu 610064, PR China.
Zhang
Ji
J
Huang
Yu
Y
Zhang
Yu
Y
Zhou
Li-Hong
LH
Jiang
Ning
N
Lin
Hong-Hui
HH
Wang
Na
N
Xia
Chuan-Qin
CQ
Yu
Xiao-Qi
XQ
D002384:Catalysis; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D000080027:Cyclams; D053837:DNA Cleavage; D004278:DNA, Superhelical / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
C524279:(2,3,5,6,8,9,11,12-octahydro-N-(3-(1,4,7,10-tetraazacyclododec-1-yl)propyl)-1,4,7,10,13-benzopentaoxacyclopentadecin-15-amine)copper(II); D000080027:Cyclams; D004278:DNA, Superhelical; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D003035:Cobalt; D003300:Copper; C038072:cyclen; D015032:Zinc