[Clinical significance of cytokine level and T-cell lymphocyte response to B and C hepatic viral antigens in patients with type C and B+C hepatitis receiving antiviral therapy].
The authors studied the levels of cytokines (interleukin (IL)-1, IL-2, IL-4, IL-6, and interferon-gamma (IFN-gamma)) and cell response to HBV and HCV in the dynamics in patients with acute mixed hepatitis (B+C) who recovered or became chronically ill, as well as before and after treatment of hepatitis C. Patients who later recovered had high levels of IL-2 and IFN-gamma during the acute phase of the disease, and displayed T-lymphocyte sensitization to HbeAg, Hbcore Ag, and the non-structural protein HCV NS3. A significant elevation of IL-2 level and, especially, IFN-gamma level, as well as the appearance of T-lymphocyte response to HCV NS3, HCVcore Ag, and HCV NS4 was observed during antiviral therapy.
Sobolevskaia
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Korochkina
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D000998:Antiviral Agents / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000276:immunology* / Q000503:physiopathology; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*
D000998:Antiviral Agents; D016207:Cytokines