title: Modulation of somatosensory evoked potentials using transcranial magnetic intermittent theta burst stimulation.
abstract: OBJECTIVE
  To study the modulation of somatosensory evoked potentials (SEP) using transcranial magnetic intermittent theta burst stimulation (iTBS) over human primary motor (M1) and sensory (S1) cortices.
  
  
  METHODS
  Eleven healthy subjects participated in the study. Median nerve SEP were elicited by electrical stimulation at the right wrist before and after 600-pulse iTBS over M1 or S1 of the left hemispheres at the intensity of 80% active motor threshold.
  
  
  RESULTS
  iTBS over S1 facilitated the N20o-N20p, N20p-P25 and P25-N33 amplitudes significantly and the maximal effect appeared 15 min after the stimulation. The facilitating effect was observed when the initial phase of the current in the brain was directed antero-medially, whereas the facilitation did not appear when the inverted coil direction was applied. On the other hand, no changes were observed after iTBS over M1. The latencies of the measured onsets and peaks were not affected through the experiments.
  
  
  CONCLUSIONS
  iTBS over S1 has the facilitating effect on the central somatosensory pathway, and the position and direction of the coil are the determinant factors of the effects.
  
  
  CONCLUSIONS
  iTBS can be useful technique to induce synaptic plasticity in human central somatosensory pathway.
authors: Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, 8-11 Queen Square, London WC1N 3BG, UK. T.Katayama@ion.ucl.ac.uk
authors: Takayuki
authors: T
authors: Katayama
authors: John C
authors: JC
authors: Rothwell
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004558:Electric Stimulation / Q000379:methods; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D009044:Motor Cortex / Q000502:physiology*; D011930:Reaction Time; D013003:Somatosensory Cortex / Q000502:physiology*; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation