Pharmacodynamics of doxycycline in a murine malaria model.
Doxycycline is reported to impair second-generation parasite schizogony. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Doxycycline lowered the rate of parasite growth within 2 days, with maximum effect in 6 days. Addition of dihydroartemisinin led to an additive antimalarial effect.
Batty
Kevin T
KT
School of Pharmacy, Curtin University of Technology, GPO Box U1987, Perth, 6845 Western Australia, Australia. Kevin.Batty@curtin.edu.au
Law
Angela S F
AS
Stirling
Verity
V
Moore
Brioni R
BR
D000818:Animals; D000962:Antimalarials / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D037621:Artemisinins / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004318:Doxycycline / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D008288:Malaria / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010962:Plasmodium berghei / Q000187:drug effects* / Q000254:growth & development; D012717:Sesquiterpenes / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C039060:artenimol; D004318:Doxycycline