title: The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study.
abstract: A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.
authors: Helmholtz-University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. b.frank@dkfz.de
authors: Bernd
authors: B
authors: Frank
authors: Sushila H
authors: SH
authors: Rigas
authors: Justo Lorenzo
authors: JL
authors: Bermejo
authors: Miriam
authors: M
authors: Wiestler
authors: Kerstin
authors: K
authors: Wagner
authors: Kari
authors: K
authors: Hemminki
authors: Malcolm W
authors: MW
authors: Reed
authors: Christian
authors: C
authors: Sutter
authors: Barbara
authors: B
authors: Wappenschmidt
authors: Sabapathy P
authors: SP
authors: Balasubramanian
authors: Alfons
authors: A
authors: Meindl
authors: Marion
authors: M
authors: Kiechle
authors: Peter
authors: P
authors: Bugert
authors: Rita K
authors: RK
authors: Schmutzler
authors: Claus R
authors: CR
authors: Bartram
authors: Christina
authors: C
authors: Justenhoven
authors: Yon-Dschun
authors: YD
authors: Ko
authors: Thomas
authors: T
authors: Brüning
authors: Hiltrud
authors: H
authors: Brauch
authors: Ute
authors: U
authors: Hamann
authors: Paul P D
authors: PP
authors: Pharoah
authors: Alison M
authors: AM
authors: Dunning
authors: Karen A
authors: KA
authors: Pooley
authors: Douglas F
authors: DF
authors: Easton
authors: Angela
authors: A
authors: Cox
authors: Barbara
authors: B
authors: Burwinkel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D053181:Caspase 8 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D017384:Sequence Deletion; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D044465:White People
chemical_list: D053181:Caspase 8