ES-242 derivatives and cycloheptapeptides from Cordyceps sp. strains BCC 16173 and BCC 16176.
Five new ES-242 analogues ( 1- 5) were isolated together with nine known compounds ( 6- 14) from the insect pathogenic fungus Cordyceps sp. BCC 16173. A closely related strain, BCC 16176, provided cordyheptapeptide A ( 15) and small amount of its new analogue, cordyheptapeptide B ( 16), along with known ES-242s. Structures of the new bioxanthracenes, 1- 5, were determined to be 6'- O-desmethyl analogues of 6 (ES-242-4), 8, 9 (ES-242-2), 12, and 13, respectively, primarily by spectroscopic analyses. Cordyheptapeptide B ( 16) has an N-methyl- l-phenylalanine residue instead of the N-methyl- l-tyrosine in 15.
Isaka
Masahiko
M
National Center for Genetic Engineering and Biotechnology, Thailand Science Park, 113 Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand. isaka@biotec.or.th
Srisanoh
Urarat
U
Lartpornmatulee
Nattapat
N
Boonruangprapa
Tanapong
T
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D032661:Cordyceps / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D010963:Plasmodium falciparum / Q000187:drug effects; D013785:Thailand; D014709:Vero Cells
D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C508846:cordyheptapeptide A; C524908:cordyheptapeptide B