title: Prevalence of Neisseria gonorrhoeae infection in young subjects attending community clinics in South London.
abstract: OBJECTIVE
  To describe the prevalence and epidemiology of gonococcal infection in young subjects attending community clinics in South-East London.
  
  
  METHODS
  Subjects <25 years of age participating in the National Chlamydia Screening Programme were tested for gonococcal infection using a nucleic acid amplification test (strand displacement amplification assay).
  
  
  RESULTS
  10 523 tests were performed in 7369 patients (82% female) over a 2-year period in 2004 and 2005. Specimens used for tests were self-taken vulvovaginal swabs (43%), cervical swabs (40%), urine (16%) and urethral swabs (0.9%). Reasons for tests were: screening (67%), diagnosis (27%) and contacts of patients with chlamydia or gonococcus infection (7%). A significantly higher percentage of male subjects were tested as contacts (19% male vs 4% female; p<0.001). Of the 10 117 cases with definite results, 414 were positive (prevalence 4.1%, 95% CI 3.7% to 4.5%). There was a significantly higher prevalence in male subjects (5.7% male v 3.8% female; p<0.001). The average number of tests was 1.4 per patient (range 1-10). Contacts had a significantly higher prevalence (15.5%, p<0.001) than those tested for diagnostic (3.6%) or screening (3.1%) purposes. Multivariate regression analysis confirmed that there was a significantly higher prevalence in black Caribbean (5.8%, OR 2.44), black British/other black (5.6%, OR 2.33) and mixed (5.5%, OR 2.25) than white (2.4%) ethnic groups (p<0.001). Increasing age was significantly associated with lower prevalence (OR = 0.87; 95% CI 0.84 to 0.91; p<0.001). The odds of a positive test decreased by 13% for every year older.
  
  
  CONCLUSIONS
  A community-screening programme has detected a high prevalence of Neisseria gonorrhoeae in South London, especially in teenagers, male subjects and certain ethnic groups.
authors: Department of Microbiology, University Hospital Lewisham, London SE13 6LH, UK. gopal.rao@uhl.nhs.uk
authors: G Gopal
authors: GG
authors: Rao
authors: L
authors: L
authors: Bacon
authors: J
authors: J
authors: Evans
authors: Y
authors: Y
authors: Dejahang
authors: P
authors: P
authors: Michalczyk
authors: N
authors: N
authors: Donaldson
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000553:Ambulatory Care / Q000706:statistics & numerical data; D002690:Chlamydia Infections / Q000150:complications / Q000453:epidemiology; D002692:Chlamydia trachomatis; D005260:Female; D006069:Gonorrhea / Q000150:complications / Q000453:epidemiology* / Q000208:ethnology; D006801:Humans; D008131:London / Q000453:epidemiology; D008297:Male; D009344:Neisseria gonorrhoeae; D021141:Nucleic Acid Amplification Techniques; D015995:Prevalence; D012044:Regression Analysis; D017678:Sex Distribution