title: Improved dynamic susceptibility contrast (DSC)-MR perfusion estimates by motion correction.
abstract: OBJECTIVE
  To investigate the effect of patient motion on quantitative cerebral blood flow (CBF) maps in ischemic stroke patients and to evaluate the efficacy of a motion-correction scheme.
  
  
  METHODS
  Perfusion data from 25 ischemic stroke patients were selected for analysis. Two motion profiles were applied to a digital anthropomorphic brain phantom to estimate accuracy. CBF images were generated for motion-corrupted and motion-corrected data. To correct for motion, rigid-body registration was performed. The realignment parameters and mean CBF in regions of interest were recorded.
  
  
  RESULTS
  All patient data with motion exhibited visibly reduced intervolume misalignment after motion correction. Improved flow delineation between different tissues and a more clearly defined ischemic lesion (IL) were achieved in the motion-corrected CBF. A significant difference occurred in the IL (P < 0.05) for patients with severe motion with an average difference between corrupted and corrected data of 4.8 mL/minute/100 g. The phantom data supported the patient results with better CBF accuracy after motion correction and high registration accuracy (<1 mm translational and <1 degrees rotational error).
  
  
  CONCLUSIONS
  Motion degrades flow differentiation between adjacent tissues in CBF maps and can cause ischemic severity to be underestimated. A registration motion correction scheme improves dynamic susceptibility contrast (DSC)-MR perfusion estimates.
authors: Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada.
authors: Robert K
authors: RK
authors: Kosior
authors: Jayme C
authors: JC
authors: Kosior
authors: Richard
authors: R
authors: Frayne
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007511:Ischemia / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009068:Movement; D010477:Perfusion; D019047:Phantoms, Imaging; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media