title: EBV viral load in tumor tissue is an important prognostic indicator for nasal NK/T-cell lymphoma.
abstract: We retrospectively studied 19 cases of nasal NK/T-cell lymphoma for various potential prognostic factors and performed real-time quantitative polymerase chain reaction for Epstein-Barr virus (EBV) viral load in tumor tissue. Patients with a low EBV viral load (<1 copy per cell) more frequently survived for more than 2 years compared with patients with a high EBV viral load (>/=1 copies/cell) (7/7 vs 3/9; P = .014; Fisher exact test). Furthermore, the patients with low EBV viral loads had a better overall survival than patients with high viral loads (50% accumulative survival: not reached vs 4-5 months; Kaplan-Meier survival analysis; P = .049). In contrast, the overall survival of the patients did not correlate with the extent of lesion, age, stage, necrosis, histologic subtypes, CD56 expression, or angiocentric or angiodestructive growth pattern. Our findings suggest that the EBV viral load in tumor tissues is a useful indicator for predicting outcome of nasal NK/T-cell lymphoma.
authors: Department of Pathology & Laboratory Medicine, Veterans General Hospital Kaohsiung, Kaohsiung, Taiwan.
authors: Pin-Pen
authors: PP
authors: Hsieh
authors: Chun-Liang
authors: CL
authors: Tung
authors: Amy Bik-Wan
authors: AB
authors: Chan
authors: Jia-Bin
authors: JB
authors: Liao
authors: Jyh-Seng
authors: JS
authors: Wang
authors: Hui-Hwa
authors: HH
authors: Tseng
authors: Hsing-Hao
authors: HH
authors: Su
authors: Kun-Chao
authors: KC
authors: Chang
authors: Chung-Che
authors: CC
authors: Chang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020031:Epstein-Barr Virus Infections / Q000401:mortality / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D007694:Killer Cells, Natural / Q000821:virology*; D016411:Lymphoma, T-Cell, Peripheral / Q000401:mortality / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000401:mortality / Q000821:virology*; D011379:Prognosis; D012367:RNA, Viral / Q000032:analysis; D012189:Retrospective Studies; D015996:Survival Rate; D019562:Viral Load
chemical_list: D012367:RNA, Viral