title: Evaluation of texture features in spatial and frequency domain for automatic discrimination of histologic tissue.
abstract: OBJECTIVE
  To investigate the applicability of different texture features in automatic discrimination of microscopic views from benign common nevi and malignant melanoma lesions.
  
  
  METHODS
  In tissue counter analysis (TCA) the images are dissected into square elements used for feature calculation. The first class of features is based on the histogram, the co-occurrence matrix and the texture moments. The second class is derived from spectral properties of the wavelet Daubechie 4 and the Fourier transform. Square elements from images of a training set are classified by Classification and Regression Trees analysis.
  
  
  RESULTS
  Features from the histogram and the co-occurrence matrix enable correct classification of 94.7% of nevi elements and 92.6% of melanoma elements in the training set. Classification results are applied to individual test set cases. Discriminant analysis based on the percentage of "malignant elements" showed correct classification of all nevi cases and 95% of melanoma cases. Features derived from the wavelet and Fourier spectrum showed correct results for 88.8% and 79.3% of nevi and 85.6% and 81.5% of melanoma elements, respectively.
  
  
  CONCLUSIONS
  TCA is a potential diagnostic tool in automatic analysis of melanocytic skin tumors. Histogram and co-occurrence matrix features are superior to the wavelet and the Fourier features.
authors: Institute of Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria. marco.wiltgen@meduni-graz.at
authors: Marco
authors: M
authors: Wiltgen
authors: Armin
authors: A
authors: Gerger
authors: Christian
authors: C
authors: Wagner
authors: Patrick
authors: P
authors: Bergthaler
authors: Josef
authors: J
authors: Smolle
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008545:Melanoma / Q000145:classification / Q000175:diagnosis*; D009508:Nevus, Pigmented / Q000145:classification / Q000175:diagnosis*; D010781:Photography; D012878:Skin Neoplasms / Q000145:classification / Q000175:diagnosis*; D013499:Surface Properties