[Association study of an (AC)n dinucleotide repeat and schizophrenia in Asian and European populations].
Linkage studies have suggested that chromosome 15q13-q14 may harbor a susceptibility locus for schizophrenia. In the current study, the association between a (AC)n dinucleotide repeat polymorphism at D15S118 and schizophrenia was investigated using three independent samples from the Han Chinese population and the Scotland population. In the population-based study, a significant difference was found between the allele frequency distributions in schizophrenia patients and control subjects in the Scottish samples (P = 0.04), but was not replicated in the Chinese samples. In a family-based study, no significant transmission disequilibrium from heterozygous parents to affected offspring was observed. Overall, our results did not support the hypothesis that the (AC)n dinucleotide repeat polymorphism plays a major role in schizophrenia susceptibility, at least in the Chinese population. Further studies are needed to elucidate its role in schizophrenia susceptibility in European population.
Ma
Jie
J
Bio-X Center, Shanghai Jiao Tong University, Shanghai, China. tigermajie@yahoo.com.cn
Fan
Jin-Bo
JB
Wu
Sheng-Nan
SN
Zhang
Chang-Shun
CS
Ji
Bao-Hu
BH
Wang
Lei
L
Li
Xing-Wang
XW
Gu
Niu-Fan
NF
Feng
Guo-Yin
GY
St Clair
David
D
He
Lin
L
D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D018900:Dinucleotide Repeats / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D012606:Scotland; D044465:White People / Q000235:genetics*; D055815:Young Adult