[Depressive disturbances during antiviral therapy in patients with type C hepatitis].
The article presents the results of a clinico-psychopathological study of depressive disorder (DD) in 91 patients with chronic C hepatitis and no psychiatric background during combined antiviral therapy (AVT) with interferon-alpha (IFN-alpha) and ribavirin. Depression developed in 39 or 43% of the patients. Moderate or severe depressions (46% and 31%, respectively) prevailed. Clinical features that were different in cases of IFNa-induced depression and endogenous DD were revealed. The severity of depression did not correlate with the severity of the underlying disease, the duration of AVT, and the type of used. The antidepressants and remeron proved to be effective in treatment of IFN-alpha-induced depressions. In all cases, treatment with antidepressants made it possible to carry out complete AVT.
Ignatova
T M
TM
Kinkul'kina
M A
MA
Morozov
A O
AO
Avdeeva
T I
TI
Volkov
A V
AV
Tikhonova
Iu G
IuG
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000453:epidemiology*; D004358:Drug Therapy / Q000523:psychology* / Q000706:statistics & numerical data*; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D000998:Antiviral Agents; D016898:Interferon-alpha