title: Mechanism of infarction involving ipsilateral carotid and posterior cerebral artery territories.
abstract: BACKGROUND
  We investigated the potential mechanism of infarction involving the territories of both the internal carotid artery (ICA) and the ipsilateral posterior cerebral artery (PCA).
  
  
  METHODS
  Among consecutive patients with an ischemic stroke who had undergone both diffusion-weighted magnetic resonance imaging (DWI) and cerebral angiography, those who were found to have acute lesions in the ipsilateral ICA and PCA territories on DWI were selected for this study. The mechanism of infarction was sought by investigating angiographic findings and DWI lesion patterns. The frequency of patency between the ICA and PCA in the patient group was compared with that in the normal control group.
  
  
  RESULTS
  Infarctions involving ipsilateral ICA and PCA territories were rare (21 of 1,388 patients, 1.5%). Sixteen of those 21 patients (76%) demonstrated steno-occlusive lesions of the relevant ICA. Cardioembolic sources were rarely found. All but 1 patient with fetal-type PCA (fPCA) or the posterior communicating artery demonstrated significant ICA stenosis. The fPCA was more frequently found in the ipsilateral hemisphere of patients with an infarction than in the control group (44.4 vs. 18.5%, p = 0.006). Ischemic lesions in the ICA territory were usually small but multiple, and those in the PCA territory were single and located in the cortex.
  
  
  CONCLUSIONS
  Large artery atherosclerosis of the carotid artery was very common in patients with infarctions involving the ipsilateral ICA and PCA territories. Extracranial cervical artery evaluation is indispensable in those patients.
authors: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
authors: Jae Hoon
authors: JH
authors: Yang
authors: Hye-Yoen
authors: HY
authors: Choi
authors: Hyo Suk
authors: HS
authors: Nam
authors: Seo Hyun
authors: SH
authors: Kim
authors: Sang Won
authors: SW
authors: Han
authors: Ji Hoe
authors: JH
authors: Heo
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002343:Carotid Artery, Internal / Q000473:pathology* / Q000503:physiopathology; D016893:Carotid Stenosis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D020785:Central Nervous System Vascular Malformations / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D004617:Embolism / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D020762:Infarction, Posterior Cerebral Artery / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D008875:Middle Aged; D020769:Posterior Cerebral Artery / Q000002:abnormalities / Q000473:pathology* / Q000503:physiopathology; D012042:Registries; D014654:Vascular Patency