Effect of propranolol on naming in chronic Broca's aphasia with anomia.
Previous research suggests that the noradrenergic system modulates flexibility of access to the lexical-semantic network, with propranolol benefiting normal subjects in lexical-semantic problem solving tasks. Patients with Broca's aphasia with anomia have impaired ability to access appropriate verbal output for a given visual stimulus in a naming task. Therefore, we tested naming in a pilot study of chronic Broca's aphasia patients with anomia after propranolol and after placebo in a double-blinded crossover manner. Naming was better after propranolol than after placebo, suggesting a potential benefit from propranolol in chronic Broca's aphasia with anomia. Larger follow-up studies are necessary to further investigate this effect.
Beversdorf
David Q
DQ
Department of Neurology, The Ohio State University Medical Center, Columbus, OH 43210, USA. david.beversdorf@osumc.edu
Sharma
Umesh K
UK
Phillips
Nicole N
NN
Notestine
Margaret A
MA
Slivka
Andrew P
AP
Friedman
Norman M
NM
Schneider
Sandra L
SL
Nagaraja
Haikady N
HN
Hillier
Ashleigh
A
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D000704:Analysis of Variance; D000849:Anomia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D001039:Aphasia, Broca / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D001245:Association Learning / Q000187:drug effects*; D006801:Humans; D007807:Language Tests; D008875:Middle Aged; D009275:Names; D009483:Neuropsychological Tests; D011433:Propranolol / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects; D020521:Stroke / Q000150:complications
D000319:Adrenergic beta-Antagonists; D011433:Propranolol