title: Estrogen therapy reduces nocturnal periodic limb movements.
abstract: It is believed that periodic limb movement (PLM) and more specifically, restless leg syndrome (RLS), are a common cause of insomnia. And one study in the literature examined PLM when associated to the use of estrogens. Polo-Kantola et al. [Polo-Kantola P, Rauhala E, Erkkola R, Irjala K, Polo O. Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled trial. Obstet Gynecol 2001;97(4):548-54] observed that estrogen therapy improved subjective sleep quality regardless of periodic limb movements or related arousals. Herein is a case of a symptomatic postmenopausal patient with high PLM index who complained of insomnia and leg pain. Given that the patient had hot flashes and a high Kupperman Menopausal Index (which evaluates climacteric symptoms), we decided to administer transdermal ESTRADOT 25 microg (Novartis, Brazil) twice-a-week. Our patient experienced a significant decrease in PLM as well as a great increase in REM and a slight increase in slow wave sleep (stages 3 and 4), as shown in the polysomnography. The patient reported an overall improvement in her condition.
authors: Department of Medicine and Sleep Biology, Unifesp - Universidade Federal de São Paulo, SP, Brazil. helenahachul@psicobio.epm.br
authors: Helena
authors: H
authors: Hachul
authors: Edmund Chada
authors: EC
authors: Baracat
authors: José Maria
authors: JM
authors: Soares
authors: Mauro Abi
authors: MA
authors: Haidar
authors: Marco Túlio
authors: MT
authors: de Mello
authors: Sérgio
authors: S
authors: Tufik
authors: Lia Rita Azeredo
authors: LR
authors: Bittencourt
mesh_terms: D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D012148:Restless Legs Syndrome / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology