[Novel approach toward infectious diseases--combating malaria by using genetically engineered mosquitoes].
Malaria is a devastating disease that kills millions of people every year, yet there has been little progress in controlling this disease. Mosquitoes are obligatory vectors for the disease and this part of the parasite cycle represents a potential weak link in transmission. Therefore, control of parasite development in the mosquito has considerable promise as a new approach in the fight against malaria. In recent year, methods for the genetic modification of mosquitoes have been developed, and effector genes whose products interfere with Plasmodium development in the mosquito are beginning to be identified. Here we review strategies to alter mosquito vector competence and consider issues related to translating this knowledge to field applications.
Yoshida
Shigeto
S
Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University.
Shimada
Yohei
Y
Watanabe
Hiroyuki
H
D000818:Animals; D017151:Antibodies, Catalytic; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D002268:Carboxypeptidases; D009033:Culicidae / Q000235:genetics* / Q000469:parasitology*; D049452:Green Fluorescent Proteins; D006801:Humans; D007303:Insect Vectors / Q000235:genetics* / Q000469:parasitology*; D037102:Lectins / Q000235:genetics; D008018:Life Cycle Stages; D008164:Luminescent Proteins; D008288:Malaria / Q000469:parasitology* / Q000517:prevention & control* / Q000635:transmission; D030781:Organisms, Genetically Modified / Q000235:genetics* / Q000469:parasitology*; D010961:Plasmodium / Q000254:growth & development*; D011401:Promoter Regions, Genetic; D015800:Protozoan Proteins / Q000276:immunology
D017151:Antibodies, Catalytic; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; C402644:CEL-III lectin, Cucumaria echinata; D037102:Lectins; D008164:Luminescent Proteins; C109583:Mab13-1 monoclonal antibody; D015800:Protozoan Proteins; C413663:fluorescent protein 583; C084246:ookinete surface antigen Pbs21, Plasmodium; D049452:Green Fluorescent Proteins; D002268:Carboxypeptidases