title: Clindamycin-induced acute cholestatic hepatitis.
abstract: We report a case of acute hepatotoxicity in a 42-year-old woman after administration of clindamycin for a dental infection. After 6 d of treatment, she had fatigue, nausea, vomiting, anorexia, pruritus and jaundice. Her laboratory analysis showed alanine aminotransferase (ALT), 1795 IU/L (normal range 0-40); aspartate aminotransferase (AST), 1337 IU/L (normal range 5-34); alkaline phosphatase (ALP), 339 IU/L (normal range 40-150); gamma-glutamyl transpeptidase (GGT), 148 IU/L (normal range 9-64 IU/L); total bilirubin, 4.1 mg/dL; direct bilirubin, 2.9 mg/dL and prothrombin time (PT), 13.5 s, with international normalized ratio (INR), 1.04. She was hospitalized, with immediate drug discontinuation. Her liver biopsy specimen showed mixed-type (both hepatocellular and cholestatic) hepatic injury, compatible with a diagnosis of drug-induced hepatitis. An objective causality assessment using the Naranjo probability scale suggested that clindamycin was the probable cause of the acute hepatitis. In susceptible individuals, clindamycin use may lead to acute mixed-type liver toxicity. Complete recovery may be possible if the drug is discontinued before severe liver injury is established.
authors: Department of Gastroenterology, Kocaeli University Medical Faculty, Kocaeli 41380, Turkey. caygun1@yahoo.com
authors: Cem
authors: C
authors: Aygun
authors: Orhan
authors: O
authors: Kocaman
authors: Yesim
authors: Y
authors: Gurbuz
authors: Omer
authors: O
authors: Senturk
authors: Sadettin
authors: S
authors: Hulagu
mesh_terms: D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D002981:Clindamycin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005882:Gingival Diseases / Q000188:drug therapy; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin