title: Myocardial depression in dengue hemorrhagic fever: prevalence and clinical description.
abstract: OBJECTIVE
  To determine the prevalence of myocardial depression and its effect on the clinical severity in patients with dengue hemorrhagic fever.
  
  
  METHODS
  Clinical study.
  
  
  METHODS
  King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
  
  
  METHODS
  Ninety-one children (age 10.5 +/- 2.9 yrs, male/female = 52/39) with serologically or polymerase chain reaction-proven dengue virus infection.
  
  
  METHODS
  Left ventricular ejection fraction (EF) was measured. The proportions of patients with EF <50% were identified in patients with dengue fever (DF, n = 30), dengue hemorrhagic fever without shock (DHF, n = 36), and dengue shock syndrome (DSS, n = 25). Comparisons of clinical findings were made among DSS patients with depressed ventricular function (EF <50%), fair ventricular function (EF > or =50% and <60%), and good ventricular function (EF > or = 60%). Serum troponin T was analyzed in nine patients.
  
  
  RESULTS
  EF during toxic stage was significantly lower in patients with DSS than DHF, and lower in DHF than DF (p = .05) with rapid recovery within 24-48 hrs. EF <50% was found in 6.7%, 13.8%, and 36% of patients with DF, DHF, and DSS during the toxic stage, respectively (p = .01). DSS patients with poor ventricular function had significantly more tachycardia and hepatomegaly. While end-diastolic volumes were similarly reduced, patients with lower EF tended to have lower cardiac output, required more aggressive intravenous fluid resuscitation, developed larger pleural effusion, and had higher incidence of respiratory embarrassment. No patient had elevated troponin T level.
  
  
  CONCLUSIONS
  Transient myocardial depression is not uncommon in patients with DSS. Cardiac dysfunction in children with DSS may contribute to the clinical severity and the degree of fluid overload in these patients.
authors: Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand. apichaik@yahoo.com
authors: Apichai
authors: A
authors: Khongphatthanayothin
authors: Pornthep
authors: P
authors: Lertsapcharoen
authors: Pentip
authors: P
authors: Supachokchaiwattana
authors: Vidhawas
authors: V
authors: La-Orkhun
authors: Aree
authors: A
authors: Khumtonvong
authors: Charoon
authors: C
authors: Boonlarptaveechoke
authors: Chitsanu
authors: C
authors: Pancharoen
mesh_terms: D000293:Adolescent; D009202:Cardiomyopathies / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D019595:Severe Dengue / Q000503:physiopathology*; D012720:Severity of Illness Index; D013785:Thailand / Q000453:epidemiology; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology