Death receptors and apoptosis.
Interactions between death receptors from the tumor necrosis factor superfamily and their ligands play a crucial role in the development and the integrity of the epidermis. The major consequence resulting from death receptor targeting is apoptosis. Evidence for dysregulation of death receptor signaling associated with the pathogenesis of selected cutaneous diseases, including toxic epidermal necrolysis, graft versus host disease, and skin cancer, are reviewed herein.
Contassot
Emmanuel
E
Department of Dermatology, Zurich University Hospital, Gloriastrasse 31, 8091 Zürich, Switzerland.
Gaide
Olivier
O
French
Lars E
LE
D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D053218:Receptors, Death Domain / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D012871:Skin Diseases / Q000503:physiopathology*; D012879:Skin Physiological Phenomena; D048069:Tumor Necrosis Factors / Q000502:physiology*
D053218:Receptors, Death Domain; D048069:Tumor Necrosis Factors