title: The discovery of indole-derived long acting beta2-adrenoceptor agonists for the treatment of asthma and COPD.
abstract: The design and profile of a series of indole containing long acting beta(2)-adrenoceptor agonists is described. Evaluation of these analogues using an in vitro guinea pig trachea tissue model demonstrates that analogues within this series have salmeterol-like duration of action with potential for long duration of action in humans.
authors: Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent, UK.
authors: Alan D
authors: AD
authors: Brown
authors: Mark E
authors: ME
authors: Bunnage
authors: Paul A
authors: PA
authors: Glossop
authors: Mark
authors: M
authors: Holbrook
authors: Rhys D
authors: RD
authors: Jones
authors: Charlotte A L
authors: CA
authors: Lane
authors: Russell A
authors: RA
authors: Lewthwaite
authors: Simon
authors: S
authors: Mantell
authors: Christelle
authors: C
authors: Perros-Huguet
authors: David A
authors: DA
authors: Price
authors: Rob
authors: R
authors: Webster
mesh_terms: D000318:Adrenergic beta-Agonists / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D000420:Albuterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D001682:Biological Availability; D016466:CHO Cells; D018938:Caco-2 Cells; D006224:Cricetinae; D003412:Cricetulus; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D051381:Rats; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects*; D000068299:Salmeterol Xinafoate; D013997:Time Factors; D014132:Trachea / Q000187:drug effects
chemical_list: D000318:Adrenergic beta-Agonists; D007211:Indoles; D018343:Receptors, Adrenergic, beta-2; D000068299:Salmeterol Xinafoate; D000420:Albuterol