title: Amino acid and peptide synthesis and functionalization by the reaction of thioacids with 2,4-dinitrobenzenesulfonamides.
abstract: Readily prepared amino thioacids react at room temperature in DMF in the presence of cesium carbonate with 2,4-dinitrobenzenesulfonamides to give amides. When the sulfonamide is derived from an amino acid the method results in peptide bond formation, whereas the use of carbohydrate derived sulfonamides gives neoglycoconjugates.
authors: Chemistry Department, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA. dcrich@chem.wayne.edu
authors: David
authors: D
authors: Crich
authors: Kasinath
authors: K
authors: Sana
authors: Songpo
authors: S
authors: Guo
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D004136:Dinitrobenzenes / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis*; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D004136:Dinitrobenzenes; D010455:Peptides; D013449:Sulfonamides