[Photodynamic therapy in localised prostate cancer].
Photodynamic therapy is based on the administration of an energy source in form of light of a specific wavelength, on a previously photosensitized tissue by a chemical compound, in the presence of oxygen, so that the great deal of free radicals and oxygen derivatives generated (hydroxyl compounds) produces necrosis of the treated tissue. Technique improvement during the last years has allowed its recent development as a therapeutic method for localised prostate cancer. At present, several clinical trials are ongoing in patients with organ-confined prostate cancer both as a first line and salvage treatment. There is no risk either of cancer dissemination in surrounding tissues or accumulative pharmaco-toxicity. Therefore, the technique can be repeated as often as needed and can be administered on a previously irradiated tissue. The literature review shows that photodynamic treatment will become a therapeutic option for patients with prostate cancer in the very near future.
Ramírez Backhaus
M
M
Servicio de Urología, Hospital Universitario La Fe, Valencia. ramirezbackhaus@yahoo.es
Trassierra Villa
M
M
Vera Donoso
C D
CD
Jiménez Cruz
J F
JF
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D001682:Biological Availability; D002986:Clinical Trials as Topic; D006801:Humans; D008297:Male; D010778:Photochemotherapy / Q000009:adverse effects / Q000379:methods; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry / Q000145:classification / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017382:Reactive Oxygen Species; D016879:Salvage Therapy
D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species