Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis.
Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 microg/ml and 0.13 microg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.
Byrne
Sean T
ST
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA.
Gu
Peihua
P
Zhou
Jiangbing
J
Denkin
Steven M
SM
Chong
Curtis
C
Sullivan
David
D
Liu
Jun O
JO
Zhang
Ying
Y
D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D011718:Pyrazinamide / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D013859:Thiocarbamates / Q000494:pharmacology*
D000995:Antitubercular Agents; D011759:Pyrrolidines; D013859:Thiocarbamates; C020972:pyrrolidine dithiocarbamic acid; D011718:Pyrazinamide; D004050:Ditiocarb; D012293:Rifampin