title: Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowth.
abstract: We report the case of a multifocal dysembryoplastic neuroepithelial tumor (DNT) in a 7-year-old girl with local tumor regrowth 6 years later. The tumor was localized in the right parietal lobe extending from the cortex into the periventricular white matter. After subtotal resection of a histopathologically confirmed DNT we observed unexpected tumor progression in long-term follow-up. Therefore, a second surgery was performed when the patient was 14 years of age. In neuropathological examination of the second specimen the tumor showed an increased cellularity and pleomorphism, microvascular proliferations, an elevated proliferative activity (MIB1-index focally up to 10%) and cellular atypia not typical for WHO grade I DNT. Furthermore, MRI studies showed additional supratentorial and infratentorial lesions which remained stable over years and are also well consistent with DNTs. Thus, an unusual form of a DNT with multifocal lesions, local regrowth and morphological transformation is supposed.
authors: Institute of Brain Research, University of Tuebingen, Calwerstr. 3, D-72076 Tuebingen, Germany. jens.schittenhelm@med.uni-tuebingen.de
authors: Jens
authors: J
authors: Schittenhelm
authors: Michel
authors: M
authors: Mittelbronn
authors: Markus
authors: M
authors: Wolff
authors: Jochen
authors: J
authors: Truebenbach
authors: Bernd E
authors: BE
authors: Will
authors: Richard
authors: R
authors: Meyermann
authors: Rudi
authors: R
authors: Beschorner
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018302:Neoplasms, Neuroepithelial / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010296:Parietal Lobe / Q000473:pathology* / Q000601:surgery