title: Two formulations of the agricultural pesticide adjuvant, Toximul, reduce the glycogen content of HepG2 cells.
abstract: Young mice exposed dermally to the Toximul (Tox) class of agricultural pesticide adjuvants have reduced levels of hepatic glycogen, a marker of subclinical toxicity. The present study determined whether these effects on glycogen also occurred in cultured HepG2 cells. Exposure (3 hr) to Tox resulted in significant, concentration-dependent glycogen reductions (up to 70%) relative to control values (76 +/- 3 microg glycogen/mg protein). These reductions did not appear to be due to loss of cell viability, and were reversible with Tox removal. Two different formulations of Tox (3409F and MP-A) differed significantly in the magnitudes of glycogen reduction in the HepG2 cells.
authors: Department of Physiology, Dalhousie University, Halifax, Nova Scotia, Canada.
authors: Mustafa
authors: M
authors: Al-Khalidi
authors: Philip D
authors: PD
authors: Acott
authors: John F S
authors: JF
authors: Crocker
authors: Laurette
authors: L
authors: Geldenhuys
authors: Patrick A
authors: PA
authors: O'Regan
authors: Jacqueline
authors: J
authors: Upham
authors: Mary G
authors: MG
authors: Murphy
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002626:Chemistry, Pharmaceutical; D006003:Glycogen / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009930:Organic Chemicals / Q000633:toxicity; D010575:Pesticides / Q000633:toxicity*; D013501:Surface-Active Agents / Q000633:toxicity*
chemical_list: D009930:Organic Chemicals; D010575:Pesticides; D013501:Surface-Active Agents; C019116:Toximul MP8; D006003:Glycogen