title: Dose-volume comparison of proton therapy and intensity-modulated radiotherapy for prostate cancer.
abstract: OBJECTIVE
  The contrast in dose distribution between proton radiotherapy (RT) and intensity-modulated RT (IMRT) is unclear, particularly in regard to critical structures such as the rectum and bladder.
  
  
  METHODS
  Between August and November 2006, the first 10 consecutive patients treated in our Phase II low-risk prostate proton protocol (University of Florida Proton Therapy Institute protocol 0001) were reviewed. The double-scatter proton beam plans used in treatment were analyzed for various dosimetric endpoints. For all plans, each beam dose distribution, angle, smearing, and aperture margin were optimized. IMRT plans were created for all patients and simultaneously analyzed. The IMRT plans were optimized through multiple volume objectives, beam weighting, and individual leaf movement. The patients were treated to 78 Gray-equivalents (GE) in 2-GE fractions with a biologically equivalent dose of 1.1.
  
  
  RESULTS
  All rectal and rectal wall volumes treated to 10-80 GE (percentage of volume receiving 10-80 GE [V(10)-V(80)]) were significantly lower with proton therapy (p < 0.05). The rectal V(50) was reduced from 31.3% +/- 4.1% with IMRT to 14.6% +/- 3.0% with proton therapy for a relative improvement of 53.4% and an absolute benefit of 16.7% (p < 0.001). The mean rectal dose decreased 59% with proton therapy (p < 0.001). For the bladder and bladder wall, proton therapy produced significantly smaller volumes treated to doses of 10-35 GE (p < 0.05) with a nonsignificant advantage demonstrated for the volume receiving < or =60 GE. The bladder V(30) was reduced with proton therapy for a relative improvement of 35.3% and an absolute benefit of 15.1% (p = 0.02). The mean bladder dose decreased 35% with proton therapy (p = 0.002).
  
  
  CONCLUSIONS
  Compared with IMRT, proton therapy reduced the dose to the dose-limiting normal structures while maintaining excellent planning target volume coverage.
authors: Department of Radiation Oncology, University of Florida Proton Therapy Institute, Jacksonville, FL 32206, USA. c2002@ufl.edu
authors: Carlos
authors: C
authors: Vargas
authors: Amber
authors: A
authors: Fryer
authors: Chaitali
authors: C
authors: Mahajan
authors: Daniel
authors: D
authors: Indelicato
authors: David
authors: D
authors: Horne
authors: Angela
authors: A
authors: Chellini
authors: Craig
authors: C
authors: McKenzie
authors: Paula
authors: P
authors: Lawlor
authors: Randal
authors: R
authors: Henderson
authors: Zuofeng
authors: Z
authors: Li
authors: Liyong
authors: L
authors: Lin
authors: Kenneth
authors: K
authors: Olivier
authors: Sameer
authors: S
authors: Keole
mesh_terms: D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D061766:Proton Therapy; D011832:Radiation Injuries / Q000517:prevention & control; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods / Q000592:standards; D012007:Rectum / Q000528:radiation effects; D012062:Relative Biological Effectiveness; D001743:Urinary Bladder / Q000528:radiation effects; D011522:Protons
chemical_list: D011522:Protons