Metabolic score as a novel approach to assessing preeclampsia risk.
OBJECTIVE
Clinical trials have confirmed the association of metabolic syndrome with cardiovascular disease (CVD) in women. Because recent evidence suggests that preeclampsia is a risk factor for future CVD, we sought to determine whether metabolic syndrome was associated with preeclampsia.


METHODS
As part of a large case-control study, women were prospectively identified with preeclampsia. Controls were patients presenting for delivery at term without preeclampsia. Two pregnancy-based metabolic scores (0, 1, or 2 or more) were created using initial or final pregnancy body mass index, chronic hypertension, and diabetes. Stratified analysis and logistic regression were used to evaluate the association of metabolic score with preeclampsia and disease severity.


RESULTS
For initial metabolic score, 44.1%, 42.3%, and 13.5% of cases (n = 259) and 61.5%, 33.2%, and 5.3% of controls (n = 297) had scores of 0, 1 (odds ratio [OR] 1.91, P = .002), and 2 or more (OR 2.65, P = .001), respectively.


CONCLUSIONS
Metabolic score appears to be associated independently with developing preeclampsia, particularly severe disease.
Mazar
Rebecca M
RM
Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.
Srinivas
Sindhu K
SK
Sammel
Mary D
MD
Andrela
Christina M
CM
Elovitz
Michal A
MA
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D024821:Metabolic Syndrome / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism