title: Synthesis and biodegradation of nanogels as delivery carriers for carbohydrate drugs.
abstract: Biodegradable nanogels loaded with rhodamine B isothiocyanate-dextran (RITC-Dx) as a model for water-soluble biomacromolecular drugs were prepared using atom-transfer radical polymerization (ATRP) in a cyclohexane inverse miniemulsion in the presence of a disulfide-functionalized dimethacrylate cross linker. UV-vis spectroscopy was used to characterize the extent of incorporation of RITC-Dx into the nanogels. The loading efficiency of RITC-Dx into the nanogels exceeded 80%. These nanogels were degraded into polymeric sols in a reducing environment to release the encapsulated carbohydrate drugs. The released carbohydrate biomolecules specifically interacted with concanavalin A in water, suggesting that the biodegradable nanogels could be used as carriers to deliver carbohydrate drugs that can be released upon degradation to bind to pathogens based on lectins.
authors: Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.
authors: Jung Kwon
authors: JK
authors: Oh
authors: Daniel J
authors: DJ
authors: Siegwart
authors: Krzysztof
authors: K
authors: Matyjaszewski
mesh_terms: D002241:Carbohydrates / Q000008:administration & dosage*; D003485:Cyanates; D003911:Dextrans; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D011094:Polyethyleneimine / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D012235:Rhodamines; D013053:Spectrophotometry
chemical_list: D002241:Carbohydrates; D003485:Cyanates; D003911:Dextrans; D004337:Drug Carriers; D000080385:Nanogels; D012235:Rhodamines; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine