Norway spruce galactoglucomannans exhibiting immunomodulating and radical-scavenging activities.
Wood-derived naturally acetylated galactoglucomannans (AcGGM) can be recovered even in ton-scale at mechanical pulp mills using spruce as raw material. These cell wall polysaccharides have a great potential as hydrocolloids and bioactive polymers in food and pharmaceutical applications, or as starting material for production of functional polymers. The immunostimulatory activity of both AcGGM and its deacetylated form (GGM) was now in vitro tested. The biological response of both AcGGM and GGM in the lymphocyte transformation test was dose-dependent. The direct mitogenic as well as comitogenic activities of the AcGGM were comparable to those of the immunogenic corn cob xylan used as control, and GGM showed significantly higher biological responses also at lower doses. In contrast to GGM, AcGGM possessed also DPPH radical-scavenging activity. The results suggested that the spruce AcGGM and GGM are potentially important as additives with immuno-potentiating and antioxidant properties in food products and pharmaceutical formulations.
Ebringerová
Anna
A
Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovak Republic. chemebri@savba.sk
Hromádková
Zdenka
Z
Hríbalová
Vera
V
Xu
Chunlin
C
Holmbom
Bjarne
B
Sundberg
Anna
A
Willför
Stefan
S
D000818:Animals; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors / Q000633:toxicity; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006834:Hydrazines / Q000037:antagonists & inhibitors / Q000633:toxicity; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008351:Mannans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028222:Picea; D010851:Picrates; D051381:Rats; D017208:Rats, Wistar
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006834:Hydrazines; D007155:Immunologic Factors; D008351:Mannans; D010851:Picrates; C443804:galactoglucomannan; C004931:1,1-diphenyl-2-picrylhydrazyl