Methodological considerations for research in nocturnal home hemodialysis.
Nocturnal hemodialysis (NHD) is a form of frequent, intensive renal replacement therapy, which has been suggested to offer multiple physiological benefits over conventional hemodialysis (CHD). Though the evidence supporting these advantages is steadily increasing, significant methodological challenges exist in conducting research in this area. Our review highlights these important considerations and potential biases within the present NHD literature and suggests future research opportunities.
Pauly
Robert P
RP
Department of Medicine, Division of Nephrology, Toronto General Hospital-University Health Network, Toronto, Ontario, Canada.
Boivin
Jean-François
JF
Chan
Christopher T
CT
D015331:Cohort Studies; D006437:Hemodialysis, Home; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012106:Research