title: Oxidative stress in acute ischemic stroke.
abstract: Oxidative stress plays an important role in acute ischemic stroke pathogenesis. Free radical formation and subsequent oxidative damage may be a factor in stroke severity. Serum levels of nitric oxide (NO), malondialdehyde (MDA) and glutathione (GSH) were measured within the first 48 h of stroke in 70 patients. The levels were also correlated with the clinical outcomes using Canadian Neurological Scale (CNS) scores. The results were compared with a control group consisting of 70 volunteers with similar stroke risk factors. Serum NO, MDA and GSH levels were significantly elevated in acute stroke patients. CNS score was negatively correlated with both MDA and NO levels. However, no statistically significant correlation between GSH levels and CNS scores was detected. Our results suggest deleterious effects of oxidative stress on clinical outcome in acute ischemic stroke. The elevation of GSH levels may be an adaptive mechanism during this period.
authors: Neurology Department, Medical Faculty, Adnan Menderes University, 09100, Aydin, Turkey. ozkulayca@hotmail.com
authors: Ayca
authors: A
authors: Ozkul
authors: Ali
authors: A
authors: Akyol
authors: Cigdem
authors: C
authors: Yenisey
authors: Esra
authors: E
authors: Arpaci
authors: Nefati
authors: N
authors: Kiylioglu
authors: Cengiz
authors: C
authors: Tataroglu
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D012720:Severity of Illness Index; D020521:Stroke / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D009569:Nitric Oxide; D008315:Malondialdehyde; D005978:Glutathione