Simple copper salt-catalyzed N-arylation of nitrogen-containing heterocycles with aryl and heteroaryl halides.
Relatively mild and highly efficient CuI-catalyzed N-arylation procedures for nitrogen-containing heterocycles (e.g., imidazoles, benzimidazoles, pyrroles, pyrazoles, indoles, triazoles, etc.) with aryl and heteroaryl halides have been developed. The protocols can be performed easily and tolerate a number of functional groups, such as ester, nitrile, nitro, ketone, free hydroxyl, and free primary amine on the aryl halide.
Zhu
Liangbo
L
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, West China Hospital, Sichuan University, Chengdu 610064, PR China.
Guo
Peng
P
Li
Gaocan
G
Lan
Jingbo
J
Xie
Rugang
R
You
Jingsong
J
D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D013237:Stereoisomerism
D001555:Benzene Derivatives; D006571:Heterocyclic Compounds; D006846:Hydrocarbons, Halogenated; D007454:Iodides; D003300:Copper; C073870:cuprous iodide; D009584:Nitrogen