title: Heterogeneity of epidermal growth factor receptor mutations within a mixed adenocarcinoma lung nodule.
abstract: It has been proposed that stepwise progression occurs from atypical adenomatous hyperplasia (AAH) through bronchioloalveolar carcinoma (BAC) to invasive lung adenocarcinoma. However, the underlying molecular mechanisms have not been identified. We report a patient with a mixed adenocarcinoma of the lung that had different EGFR mutations in the papillary subtype, the acinar subtype, and the surrounding AAH and BAC areas. EGFR mutations may accumulate during tumor progression and lead to heterogeneity of EGFR mutations within the tumor.
authors: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan.
authors: Hirofumi
authors: H
authors: Nakano
authors: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan; Division of Respiratory Medicine, Sasebo City General Hospital, Sasebo 857-8511, Japan. Electronic address: h-souda@hospital.sasebo.nagasaki.jp.
authors: Hiroshi
authors: H
authors: Soda
authors: Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8521, Japan.
authors: Mineyo
authors: M
authors: Takasu
authors: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan.
authors: Nanae
authors: N
authors: Tomonaga
authors: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan.
authors: Hiroyuki
authors: H
authors: Yamaguchi
authors: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan.
authors: Katsumi
authors: K
authors: Nakatomi
authors: Internal Medicine, Saint Francisco Hospital, Nagasaki 852-8125, Japan.
authors: Satoru
authors: S
authors: Fujino
authors: Department of Pathology, Nagasaki University Hospital, Nagasaki 852-8501, Japan.
authors: Tomayoshi
authors: T
authors: Hayashi
authors: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan.
authors: Yoichi
authors: Y
authors: Nakamura
authors: Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8521, Japan.
authors: Kazuhiro
authors: K
authors: Tsukamoto
authors: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan.
authors: Shigeru
authors: S
authors: Kohno
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000235:genetics* / Q000473:pathology; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009154:Mutation; D003074:Solitary Pulmonary Nodule / Q000235:genetics* / Q000473:pathology
chemical_list: D066246:ErbB Receptors