[Relation between fatigue and autonomic disturbances in multiple sclerosis].
Fatigue is a common symptom in multiple sclerosis (MS). The objective of this study was to relate fatigue and autonomic disturbances in MS. Fifty patients with MS relapsing remitting clinical form participated in this study. Thirty three (66%) were women and 17 (34%) men. Score less or equal to 3.5 in the EDSS. Five non invasive cardiovascular tests were applied in all patients for the sympathetic and parasympathetic evaluation. The results obtained in the hand grip test were increased in the blood pressure of 14.62 +/- 9.13 mmHg for the group with fatigue and of 21.68 +/- 7.18 mmHg for the non fatigue group. This difference was statistically significant (p<0.05). Conclusion is that there is a loss in the capacity to increase blood pressure in patients with fatigue suggesting a sympathetic dysfunction.
Lebre
Andréa Temponi
AT
Faculdade de Ciências Médicas, Disciplina de Neurologia, Santa Casa de São Paulo, São Paulo, SP, Brazil. atlebre@ig.com.br
Mendes
Maria Fernanda
MF
Tilbery
Charles P
CP
Almeida
Ana Lucia
AL
Scatolini Neto
Argemiro
A
D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D016009:Chi-Square Distribution; D004185:Disability Evaluation; D018450:Disease Progression; D015444:Exercise / Q000502:physiology; D005221:Fatigue / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications / Q000503:physiopathology*; D018434:Sickness Impact Profile; D018709:Statistics, Nonparametric