title: Postkeratoplasty atopic sclerokeratitis in keratoconus patients.
abstract: OBJECTIVE
  To estimate the incidence of and investigate possible risk factors for postkeratoplasty atopic sclerokeratitis in keratoconus patients undergoing keratoplasty.
  
  
  METHODS
  Retrospective, noncomparative, interventional case series.
  
  
  METHODS
  Two hundred forty-seven eyes with keratoconus.
  
  
  METHODS
  We reviewed the medical records of all keratoplasty cases of keratoconus between May 2000 and December 2005 at Tokyo Dental College Ichikawa General Hospital. The incidence and clinical details of cases consistent with postkeratoplasty atopic sclerokeratitis were recorded.
  
  
  METHODS
  Cases with acute sclerokeratitis during the early postoperative period were retrospectively evaluated.
  
  
  RESULTS
  A total of 247 keratoconus eyes were followed at our clinic after keratoplasty (mean follow-up, 18.5+/-13.0 months). Thirty-five eyes of 29 patients (14.2%) had a history of atopic dermatitis, of which 6 eyes of 5 patients (2.4%) developed postkeratoplasty atopic sclerokeratitis. Mean age of postkeratoplasty atopic sclerokeratitis patients was 29 years (range, 23-39). The mean period between keratoplasty and onset of postkeratoplasty atopic sclerokeratitis was 26 days (range, 11-41). Loosening of running sutures and wound leakage were observed in 3 eyes; persistent epithelial defects in 3 eyes; and graft melting in 2 eyes, 1 of which was perforated. Preoperative atopic blepharitis and corneal neovascularization were identified as risk factors for postkeratoplasty atopic sclerokeratitis.
  
  
  CONCLUSIONS
  Postkeratoplasty atopic sclerokeratitis is a potentially severe complication in atopic patients undergoing keratoplasty. Systemic immunosuppression may be considered in patients with active blepharitis and corneal neovascularization.
authors: Department of Ophthalmology, Tokyo Dental College, Ichikawa, Japan.
authors: Machiko
authors: M
authors: Tomita
authors: Shigeto
authors: S
authors: Shimmura
authors: Kazuo
authors: K
authors: Tsubota
authors: Jun
authors: J
authors: Shimazaki
mesh_terms: D000328:Adult; D001623:Betamethasone / Q000008:administration & dosage; D001762:Blepharitis / Q000150:complications; D016510:Corneal Neovascularization / Q000150:complications; D016572:Cyclosporine / Q000008:administration & dosage; D003876:Dermatitis, Atopic / Q000150:complications; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D015994:Incidence; D007634:Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D007640:Keratoconus / Q000601:surgery*; D015948:Keratoplasty, Penetrating; D008297:Male; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors; D015423:Scleritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013997:Time Factors; D014792:Visual Acuity
chemical_list: D007166:Immunosuppressive Agents; D009883:Ophthalmic Solutions; D016572:Cyclosporine; D001623:Betamethasone