title: Insulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adults.
abstract: Increasing evidence suggests that the insulin-like growth factor (IGF)-axis may play a role in glucose metabolism and may also be associated with systemic inflammation. The aim of this study was to evaluate the association of insulin-like growth factor-1 (IGF-I) and its binding proteins, IGFBP-1 and IGFBP-3, with glucose intolerance and inflammation among older adults. We conducted a cross-sectional analysis in a in a random subsample (n=922) of the Cardiovascular Health Study (CHS), a prospective cohort of men and women > or = 65 years. Mean IGFBP-1 levels were significantly lower in older adults with impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and diabetes compared to those with normal fasting and post-load glucose. High IGFBP-1 was associated with a reduced prevalence of IGT and IFG; the multivariable OR between extreme quartiles of IGFBP-1 was 0.60 (95% CI: 0.37, 0.95; p-trend: 0.03) for IGT and 0.41 (95% CI: 0.26, 0.64; p-trend: <0.01) for IFG. We did not find any significant association between IGF-I and glucose intolerance in this study and the association for IGFBP-3 was less clear. However, low levels of IGF-I and IGFBP-3 were associated with increased levels of markers of inflammation including C-reactive protein and interleukin-6 levels. We conclude that among adults > or = 65 years, low IGFBP-1 levels are associated with increased prevalence of glucose intolerance. We did not confirm prior associations of low IGF-I with glucose intolerance in this cohort of older individuals.
authors: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 11375, USA. srajpath@aecom.yu.edu
authors: Swapnil N
authors: SN
authors: Rajpathak
authors: Aileen P
authors: AP
authors: McGinn
authors: Howard D
authors: HD
authors: Strickler
authors: Thomas E
authors: TE
authors: Rohan
authors: Michael
authors: M
authors: Pollak
authors: Anne R
authors: AR
authors: Cappola
authors: Lewis
authors: L
authors: Kuller
authors: XiaoNan
authors: X
authors: Xue
authors: Anne B
authors: AB
authors: Newman
authors: Elsa S
authors: ES
authors: Strotmeyer
authors: Bruce M
authors: BM
authors: Psaty
authors: Robert C
authors: RC
authors: Kaplan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000453:epidemiology*; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood; D008297:Male; D015398:Signal Transduction / Q000502:physiology; D013002:Somatomedins / Q000032:analysis* / Q000378:metabolism
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins