Clinical applications of molecular haematology: an overview.
Haematological disorders are getting more and more molecularly defined. This is specially so in the field of haematological malignancies. The molecular understanding has helped in fine-tuning the diagnosis, prognosis and management. The tests are becoming widely available and they enjoy both sensitivity and specificity. Following is an overview of clinical applications of molecular haematology, especially in the field of chronic myeloid leukaemia, chronic eosinophilic leukaemia, bcr abl negative chronic myeloproliferative disorders and acute promyelocytic leukaemia.
Bain
Barbara J
BJ
Department of Haematology, St Mary's Hospital Campus of Imperial College, St Mary's hospital, Praed Street, London W2 1NY, United Kingdom.
D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis; D053614:Janus Kinase 2 / Q000235:genetics; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis; D015473:Leukemia, Promyelocytic, Acute; D008967:Molecular Biology; D009196:Myeloproliferative Disorders / Q000175:diagnosis; D011379:Prognosis
C507924:JAK2 protein, human; D053614:Janus Kinase 2