title: Development of an improved method for trace analysis of chloramphenicol using molecularly imprinted polymers.
abstract: A confirmatory method is described for the determination of the illegal antibiotic chloramphenicol using a specifically developed molecularly imprinted polymer (MIP) as the sample clean-up technique. The newly developed MIP was produced using an analogue to chloramphenicol as the template molecule. Using an analogue of the analyte as the template avoids a major traditional drawback associated with MIPs of residual template leeching or bleeding. The MIP described was used as a solid-phase extraction phase for the extraction of chloramphenicol from various sample matrices including honey, urine, milk and plasma. A full analytical method with quantification by LC-MS/MS is described. The method was fully validated according to the European Union (EU) criteria for the analysis of veterinary drug residues.
authors: MIP Technologies AB, Box 737, Lund 22007, Sweden. brian.boyd@miptechnologies.com
authors: Brian
authors: B
authors: Boyd
authors: Henrik
authors: H
authors: Björk
authors: Johan
authors: J
authors: Billing
authors: Olga
authors: O
authors: Shimelis
authors: Sara
authors: S
authors: Axelsson
authors: Maria
authors: M
authors: Leonora
authors: Ecevit
authors: E
authors: Yilmaz
mesh_terms: D000818:Animals; D002138:Calibration; D002417:Cattle; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002701:Chloramphenicol / Q000032:analysis* / Q000097:blood / Q000652:urine; D006722:Honey / Q000032:analysis; D006801:Humans; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D052616:Solid Phase Extraction
chemical_list: D011108:Polymers; D002701:Chloramphenicol