[Antiglucocorticoid, adrenonegative and antihypertensive effects of pyrogenal].
Intramuscular injection of pyrogenal (6.25 mcg/kg) to rats causes hypernitroxiduria, prevents a decrease of thymocytes count after subcutaneous injection of triamcinolone acetonide (2 mg/kg), leads to a moderate blood pressure decrease in hypertensive NISAG rats. Administration of equipotent dose of pyrogenal to mice (12.5 mcg/kg) reduces a mortality rate after subcutaneous injection of epinephrine (14 mg/kg). These results are discussed in the context of immunoprophylaxis of non-infectious pathology.
Volchegorskiĭ
I A
IA
Tseĭlikman
V E
VE
Rassokhina
L M
LM
Vokhmintsev
Ia A
IaA
Kriukov
F B
FB
Markel'
A L
AL
Kozochkin
D A
DA
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002452:Cell Count; D004837:Epinephrine / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D005938:Glucocorticoids / Q000378:metabolism* / Q000494:pharmacology; D007273:Injections, Intramuscular; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D009566:Nitrates / Q000652:urine; D009569:Nitric Oxide / Q000096:biosynthesis; D009573:Nitrites / Q000652:urine; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects
D000276:Adjuvants, Immunologic; D000959:Antihypertensive Agents; D005938:Glucocorticoids; D008070:Lipopolysaccharides; D009566:Nitrates; D009573:Nitrites; C009136:pyrogenal; D009569:Nitric Oxide; D004837:Epinephrine