title: Numerical modelling of simulated blood flow in idealized composite arterial coronary grafts: transient flow.
abstract: In composite arterial coronary grafts (CACGs), transport phenomena and geometry may considerably alter blood flow dynamics. CACGs aim at revascularizing pathological arteries according to the human anatomy. However, the exact mechanisms causing the failure of coronary bypass grafting are not yet well elucidated. In the present study, computational fluid dynamics (CFD) techniques are applied for the simulation of multi-branched CACGs under physiologically realistic inflow waveforms. The numerical solution is obtained by a finite-volume method formulated in non-orthogonal, curvilinear coordinates and a multi-grid approach. The geometrical models, consisting of idealized and rigid vessels, include the typical T- and a rather new pi-graft configuration. The stenotic effect is also investigated by comparing computational results for three different degrees of area constriction, namely 25%, 50% and 75%, as well as the case without stenosis. Different grafting distances and various inflow rate ratios are imposed, to give an insight into haemodynamical alterations of CACGs and to study the process of restenosis. The results focus on the interaction between the grafts and coronary flows in terms of spatial and temporal variations of velocity and wall shear stress (WSS) distribution. Prominent variations among the different geometries, concerning the velocity profiles and secondary flow motion, are shown. Moreover, the residual flow emerging from different degrees of area constriction shows that low and oscillating shear stresses may arise for even moderate stenotic fields.
authors: School of Chemical Engineering, National Technical University of Athens, 9 Heroon Polytechniou Str., Zographou Campus, 15780 Athens, Attiki, Greece.
authors: A K
authors: AK
authors: Politis
authors: G P
authors: GP
authors: Stavropoulos
authors: M N
authors: MN
authors: Christolis
authors: P G
authors: PG
authors: Panagopoulos
authors: N S
authors: NS
authors: Vlachos
authors: N C
authors: NC
authors: Markatos
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000502:physiology*; D023903:Coronary Restenosis / Q000503:physiopathology; D023921:Coronary Stenosis / Q000503:physiopathology; D003971:Diastole / Q000502:physiology; D018056:Hemorheology; D006801:Humans; D008954:Models, Biological; D011673:Pulsatile Flow / Q000502:physiology; D013314:Stress, Mechanical; D013599:Systole / Q000502:physiology