Investigation of lipid peroxide and glutathione redox status of chicken concerning on high dietary selenium intake.
This study was designed to investigate the effects of excess (24.5 mg Se/kg feed) inorganic and organic dietary selenium supplementation on 3-week-old broilers. The experiments lasted 4 days. Intensity of lipid peroxidation processes (malondialdehyde, MDA) and the amount (reduced glutathione, GSH) and activity (glutathione peroxidase activity, GSHPx) of gluathione redox system were measured in blood plasma, red blood cell hemolysate and liver. Voluntary feed intake in the selenium-treated groups reduced remarkably. Elevated GSH concentration and GSHPx activity were measured in plasma and liver of both selenium-treated groups compared to the untreated control and the 'pair-fed' controls. The lipid peroxidation processes in the liver showed higher intensity than the control due to both selenium treatment. The applied dose of selenite and selenomethionine does not inhibit, but even improves the activity of glutathione redox system in the liver during the early period of selenium exposure.
Balogh
K
K
Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, H-2103 Gödöllo, Hungary. Balogh.Krisztian@mkk.szie.hu
Weber
Mária
M
Erdélyi
Márta
M
Mézes
M
M
D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002645:Chickens / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010084:Oxidation-Reduction; D012643:Selenium / Q000494:pharmacology*
D000975:Antioxidants; D008054:Lipid Peroxides; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D005978:Glutathione; D012643:Selenium