title: Postoperative hyperthermia, rhabdomyolysis, critical temperature, and death in a former premature infant after his ninth general anesthetic.
abstract: An 8-mo-old infant born at 24-wk of gestation died unexpectedly 12 h after his ninth uneventful general anesthetic. Preoperatively, he required low-flow nasal oxygen due to bronchopulmonary dysplasia, chronic diuretic therapy, and IV alimentation. As planned preoperatively, the infant remained tracheally intubated after his elective surgery and went to the Neonatal Intensive Care Unit in stable condition. However, over the next 6 h, he developed fever. The diagnosis of postoperative sepsis was considered. One hour before his death his temperature reached 43 degrees C. Autopsy documented Duchenne's muscular dystrophy and renal tubules containing myoglobin.
authors: Department of Anesthesiology, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors: Aparna
authors: A
authors: Phadke
authors: Lynn M
authors: LM
authors: Broadman
authors: Barbara W
authors: BW
authors: Brandom
authors: John
authors: J
authors: Ozolek
authors: Peter J
authors: PJ
authors: Davis
mesh_terms: D000701:Analgesics, Opioid; D000768:Anesthesia, General / Q000009:adverse effects*; D017809:Fatal Outcome; D005283:Fentanyl; D005334:Fever / Q000209:etiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008738:Methyl Ethers; D020388:Muscular Dystrophy, Duchenne / Q000473:pathology; D011183:Postoperative Complications / Q000209:etiology; D015742:Propofol; D012206:Rhabdomyolysis / Q000209:etiology*; D000077149:Sevoflurane
chemical_list: D000701:Analgesics, Opioid; D008738:Methyl Ethers; D000077149:Sevoflurane; D005283:Fentanyl; D015742:Propofol