title: Age-related botulinum toxin effects on muscle fiber conduction velocity in non-injected muscles.
abstract: OBJECTIVE
  We studied systemic effects of botulinum toxin (BTX) treatment on muscle fiber conduction velocity (MFCV) and possible effects of age.
  
  
  METHODS
  MFCV was determined by an invasive EMG method in the biceps brachii muscle. Seventeen BTX treated patients and 58 controls were investigated. BTX injections were applied in the neck region or forearm, depending on the indication for treatment.
  
  
  RESULTS
  We found an increased ratio between fastest and slowest muscle fiber conduction velocity in BTX treated patients. This suggests systemic BTX effects on MFCV distant from the site of injection, probably fiber atrophy secondary to end-plate dysfunction. Furthermore, we found an increased MFCV in part of the patients, suggesting hypertrophy of some of the muscle fibers. No relation was found between the MFCV disturbances and treatment duration or the cumulative dose of BTX.
  
  
  CONCLUSIONS
  We found a strong positive correlation between the age and the BTX-induced changes of MFCV in patients, suggesting a BTX related, diminished repair capacity of end-plates or muscle fibers with age.
  
  
  CONCLUSIONS
  Our findings suggest a reduced repair capacity of end-plates or muscle fibers in elderly patients. MFCV is a sensitive method to show changes related to damage and compensation of the neuromuscular system. Our finding suggests a decreasing efficiency of repair mechanisms in aging.
authors: Department of Clinical Neurophysiology, University Hospital Groningen, Groningen, The Netherlands. f.lange@neuro.umcg.nl
authors: Fiete
authors: F
authors: Lange
authors: Tiemen W
authors: TW
authors: van Weerden
authors: Johannes H
authors: JH
authors: van der Hoeven
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D000367:Age Factors; D000368:Aged; D018726:Anti-Dyskinesia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001905:Botulinum Toxins / Q000494:pharmacology* / Q000627:therapeutic use; D004576:Electromyography; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000187:drug effects* / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000294:innervation / Q000503:physiopathology; D009431:Neural Conduction / Q000187:drug effects* / Q000502:physiology; D014103:Torticollis / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins