Orthostatic hypotension in the elderly: diagnosis and treatment.
Orthostatic hypotension is a common problem among elderly patients, associated with significant morbidity and mortality. While acute orthostatic hypotension is usually secondary to medication, fluid or blood loss, or adrenal insufficiency, chronic orthostatic hypotension is frequently due to altered blood pressure regulatory mechanisms and autonomic dysfunction. The diagnostic evaluation requires a comprehensive history including symptoms of autonomic nervous system dysfunction, careful blood pressure measurement at various times of the day and after meals or medications, and laboratory studies. Laboratory investigation and imaging studies should be based upon the initial findings with emphasis on excluding diagnoses of neurodegenerative diseases, amyloidosis, diabetes, anemia, and vitamin deficiency as the cause. Whereas asymptomatic patients usually need no treatment, those with symptoms often benefit from a stepped approach with initial nonpharmacological interventions, including avoidance of potentially hypotensive medications and use of physical counter maneuvers. If these measures prove inadequate and the patient remains persistently symptomatic, various pharmacotherapeutic agents can be added, including fludrocortisone, midodrine, and nonsteroidal anti-inflammatory drugs. The goals of treatment are to improve symptoms and to make the patient as ambulatory as possible rather then trying to achieve arbitrary blood pressure goals. With proper evaluation and management, the occurrence of adverse events, including falls, fracture, functional decline, and myocardial ischemia, can be significantly reduced.
Gupta
Vishal
V
Beth Israel Deaconess Medical Center, Hebrew SeniorLife, and Harvard Medical School, Boston, Mass 02131, USA.
Lipsitz
Lewis A
LA
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001795:Blood Pressure Determination / Q000379:methods; D002110:Caffeine / Q000627:therapeutic use; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004921:Erythropoietin / Q000627:therapeutic use; D005438:Fludrocortisone / Q000627:therapeutic use; D005853:Geriatrics / Q000379:methods*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D008879:Midodrine / Q000627:therapeutic use; D011187:Posture / Q000502:physiology; D015995:Prevalence; D011448:Prostaglandin Antagonists / Q000627:therapeutic use; D040242:Risk Reduction Behavior; D014481:United States / Q000453:epidemiology
D000316:Adrenergic alpha-Agonists; D000893:Anti-Inflammatory Agents; D000697:Central Nervous System Stimulants; D011448:Prostaglandin Antagonists; D004921:Erythropoietin; D002110:Caffeine; D008879:Midodrine; D005438:Fludrocortisone