Limitations of contemporary antidepressants: tolerability.
Antidepressant side effects are common and persistent. They can contribute to discomfort, distress, disability, morbidity, and mortality and can compromise the efficacy of treatments. Reducing the side effect burden, either by developing treatments that have a lower incidence of side effects or by using treatment strategies that alleviate side effects, would improve the standard of care for mood and anxiety disorders. In this article, the rates of common adverse events among the newer (posttricyclic era) antidepressants are compared with those among the selective serotonin reuptake inhibitors, the most popular, contemporary first-line treatments for depression.
Papakostas
George I
GI
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. gpapakostas@partners.org
D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D009765:Obesity / Q000139:chemically induced / Q000453:epidemiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced* / Q000453:epidemiology; D013406:Suicide, Attempted / Q000706:statistics & numerical data*; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects
D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors