title: Colorectal neoplasm: magnetic resonance colonography with fat enema-initial clinical experience.
abstract: OBJECTIVE
  To assess Magnetic resonance colonography with fat enema as a method for detection of colorectal neoplasm.
  
  
  METHODS
  Consecutive twenty-two patients underwent MR colonography with fat enema before colonoscopy. T1-weighted three-dimensional fast spoiled gradient-echo with inversion recovery sequence was acquired with the patient in the supine position before and 75 s after Gadopentetate Dimelumine administration. Where by, pre and post MR coronal images were obtained with a single breath hold for about 20 s to cover the entire colon. The quality of MR colonographs and patients' tolerance to fat contrast medium was investigated. Colorectal neoplasms identified by MR colonography were compared with those identified on colonoscopy and sensitivity of detecting the lesions was calculated accordingly.
  
  
  RESULTS
  MR colonography with fat enema was well tolerated without sedation and analgesia. 120 out of 132 (90.9%) colonic segments were well distended and only 1 (0.8%) colonic segment was poor distension. After contrast enhancement scan, mean contrast-to-noise ratio (CNR) value between the normal colonic wall and lumen was 18.5 +/- 2.9 while mean CNR value between colorectal neoplasm and lumen was 20.2 +/- 3.1. By Magnetic resonance colonography, 26 of 35 neoplasms (sensitivity 74.3%) were detected. However, sensitivity of MRC was 95.5% (21 of 22) for neoplasm larger than 10 mm and 55.6% (5 of 9) for 5-10 mm neoplasm.
  
  
  CONCLUSIONS
  MR colonography with fat enema and T1-weighted three-dimensional fast spoiled gradient-echo with inversion recovery sequence is feasible in detecting colorectal neoplasm larger than 10 mm.
authors: Department of Radiology, Fudan University Cancer Hospital Shanghai 200032, China.
authors: Shuai
authors: S
authors: Zhang
authors: Jun-Wei
authors: JW
authors: Peng
authors: Qiang-Ying
authors: QY
authors: Shi
authors: Feng
authors: F
authors: Tang
authors: Min-Guo
authors: MG
authors: Zhong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003106:Colon / Q000473:pathology; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D004733:Enema / Q000379:methods*; D005223:Fats / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D005223:Fats