title: Targeted agents: the rules of combination.
abstract: The success of molecularly targeted agents (MTA) in the treatment of cancer has led to the investigation of their use in combination with other MTAs and with conventional chemotherapies. An overview of the MTAs that have emerged as Food and Drug Administration-approved drugs is presented, along with a framework for the consideration of how MTAs can best be combined to maximize therapeutic effect.
authors: Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA. ekwak@partners.org
authors: Eunice L
authors: EL
authors: Kwak
authors: Jeffrey W
authors: JW
authors: Clark
authors: Bruce
authors: B
authors: Chabner
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D017277:Drug Approval; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D000970:Antineoplastic Agents