title: Cardiopulmonary resuscitation alone vs. cardiopulmonary resuscitation plus automated external defibrillator use by non-healthcare professionals: a meta-analysis on 1583 cases of out-of-hospital cardiac arrest.
abstract: BACKGROUND
  Out-of-hospital cardiac arrest (OHCA) accounts for 250.000-350.000 sudden cardiac deaths per year in the United States. The availability of automated external defibrillators (AEDs) promoted the implementation of public access defibrillation programs based on out-of-hospital early defibrillation by non-healthcare professionals.
  
  
  OBJECTIVE
  To perform a systematic review and a meta-analysis of the pooled effect of studies comparing the outcome of pts receiving cardiopulmonary resuscitation plus AED therapy (CPR+AED) vs. cardiopulmonary resuscitation (CPR) alone, both delivered by non-healthcare professionals, for the treatment of OHCA.
  
  
  METHODS
  We performed a search of the relevant literature exploring major scientific databases, carrying out a hand search of key journals, analysing conference proceedings and abstracts and discussing the topic with other researchers. Two analyses were planned to assess the outcomes of interest (survival to hospital admission and survival to hospital discharge).
  
  
  RESULTS
  Three studies were selected for the meta-analysis. The first meta-analysis evidenced a RR of 1.22 (95% C.I.: 1.04-1.43) of surviving to hospital admission for people treated with CPR+AED as compared to CPR-only. The second meta-analysis showed a RR of 1.39 (95% C.I.: 1.06-1.83) of surviving to hospital discharge for people treated with CPR+AED as compared to CPR-only.
  
  
  CONCLUSIONS
  The results of our meta-analysis demonstrate that programs based on CPR plus early defibrillation with AEDs by trained non-healthcare professionals offer a survival advantage over CPR-only in OHCA. The conclusions of our meta-analysis add to previous evidence in favour of developing public-health strategies based on AED use by trained layrescuers.
authors: Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy. tomamaso.sanna@rm.unicatt.it
authors: Tommaso
authors: T
authors: Sanna
authors: Giuseppe
authors: G
authors: La Torre
authors: Chiara
authors: C
authors: de Waure
authors: Andrea
authors: A
authors: Scapigliati
authors: Walter
authors: W
authors: Ricciardi
authors: Antonio
authors: A
authors: Dello Russo
authors: Gemma
authors: G
authors: Pelargonio
authors: Michela
authors: M
authors: Casella
authors: Fulvio
authors: F
authors: Bellocci
mesh_terms: D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D017028:Caregivers; D047548:Defibrillators; D004554:Electric Countershock / Q000295:instrumentation*; D004632:Emergency Medical Services / Q000379:methods*; D006323:Heart Arrest / Q000628:therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic