The renaissance of H/D exchange.
The increasing demand for stable isotopically labeled compounds has led to an increased interest in H/D-exchange reactions at carbon centers. Today deuterium-labeled compounds are used as internal standards in mass spectrometry or to help elucidate mechanistic theories. Access to these deuterated compounds takes place significantly more efficiently and more cost effectively by exchange of hydrogen by deuterium in the target molecule than by classical synthesis. This Review will concentrate on the preparative application of the H/D-exchange reaction in the preparation of deuterium-labeled compounds. Advances over the last ten years are brought together and critically evaluated.
Atzrodt
Jens
J
Isotope Chemistry Metabolite Synthesis (ICMS), Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926 Frankfurt am Main, Germany. jens.atzrodt@sanofi-aventis.com
Derdau
Volker
V
Fey
Thorsten
T
Zimmermann
Jochen
J
D002384:Catalysis; D041961:Deuterium Exchange Measurement / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008670:Metals / Q000737:chemistry; D013237:Stereoisomerism
D008670:Metals