title: Mucoadhesive and elastic films based on blends of chitosan and hydroxyethylcellulose.
abstract: Mucoadhesive polymeric films have been prepared based on blends of chitosan and hydroxyethylcellulose. The blends have been characterized by IR spectroscopy, DSC, WAXD, TGA, SEM, and mechanical testing. It is demonstrated that the mechanical properties of chitosan are improved significantly upon blending with hydroxyethylcellulose. An increase in hydroxyethylcellulose content in the blends makes the materials more elastic. The thermal treatment of the blends at 100 degrees C leads to partial cross-linking of the polymers and formation of water-insoluble but swellable materials. The adhesion of the films towards porcine buccal mucosa decreases with increasing hydroxyethylcellulose content in the blends.
authors: Shanghai University, Department of Polymer Materials, 20 Chengzhong Street, Jiading, Shanghai, 201800, China.
authors: Kun
authors: K
authors: Luo
authors: Jingbo
authors: J
authors: Yin
authors: Olga V
authors: OV
authors: Khutoryanskaya
authors: Vitaliy V
authors: VV
authors: Khutoryanskiy
mesh_terms: D000818:Animals; D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004548:Elasticity; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009061:Mouth Mucosa / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D034421:Sus scrofa; D014014:Tissue Adhesives / Q000138:chemical synthesis* / Q000378:metabolism; D014961:X-Ray Diffraction
chemical_list: D014014:Tissue Adhesives; D002482:Cellulose; C002283:hydroxyethylcellulose; D048271:Chitosan