title: Classification of intervertebral disk degeneration with axial T2 mapping.
abstract: OBJECTIVE
  The aim of this study was to establish an MRI classification system for intervertebral disks using axial T2 mapping, with a special focus on evaluating early degenerative intervertebral disks.
  
  
  METHODS
  Twenty-nine healthy volunteers (19 men, 10 women; age range, 20-44 years; mean age, 31.8 years) were studied, and axial T2 mapping was performed for the L3-L4, L4-L5, and L5-S1 intervertebral disks. Grading was performed using three classification systems for degenerative disks: our system using axial T2 mapping and two other conventional classification systems that focused on the signal intensity of the nucleus pulposus or the structural morphology in sagittal T2-weighted MR images. We analyzed the relationship between T2, which is known to correlate with change in composition of intervertebral disks, and degenerative grade determined using the three classification systems.
  
  
  RESULTS
  With axial T2 mapping, differences in T2 between grades I and II were smaller and those between grades II and III, and between grades III and IV, were larger than those with the other grading systems. The ratio of intervertebral disks classified as grade I was higher with the conventional classification systems than that with axial T2 mapping. In contrast, the ratio of intervertebral disks classified as grade II or III was higher with axial T2 mapping than that with the conventional classification systems.
  
  
  CONCLUSIONS
  Axial T2 mapping provides a more T2-based classification. The new system may be able to detect early degenerative changes before the conventional classification systems can.
authors: Department of Clinical Research, Unit for MR Spectroscopy and Methodology, University of Bern, CH-3010 Bern, Switzerland. atsuyan1@pa2.so-net.ne.jp
authors: Atsuya
authors: A
authors: Watanabe
authors: Lorin M
authors: LM
authors: Benneker
authors: Chris
authors: C
authors: Boesch
authors: Tomoko
authors: T
authors: Watanabe
authors: Takayuki
authors: T
authors: Obata
authors: Suzanne E
authors: SE
authors: Anderson
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007403:Intervertebral Disc / Q000473:pathology*; D007405:Intervertebral Disc Displacement / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity