title: Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice.
abstract: Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABA(B) agonists could be a new therapeutic reagent for obesity.
authors: Department of Endocrinology and Diabetes, Field of Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
authors: Ikuko
authors: I
authors: Sato
authors: Hiroshi
authors: H
authors: Arima
authors: Noriyuki
authors: N
authors: Ozaki
authors: Nobuaki
authors: N
authors: Ozaki
authors: Minemori
authors: M
authors: Watanabe
authors: Motomitsu
authors: M
authors: Goto
authors: Hiroshi
authors: H
authors: Shimizu
authors: Masayuki
authors: M
authors: Hayashi
authors: Ryouichi
authors: R
authors: Banno
authors: Hiroshi
authors: H
authors: Nagasaki
authors: Yutaka
authors: Y
authors: Oiso
mesh_terms: D054392:Adipokines / Q000097:blood; D052436:Adipose Tissue, White / Q000187:drug effects / Q000473:pathology; D000284:Administration, Oral; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects / Q000378:metabolism; D001418:Baclofen / Q000008:administration & dosage / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects; D004032:Diet; D004435:Eating / Q000187:drug effects*; D018755:GABA Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D058786:GABA-B Receptor Agonists; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009478:Neuropeptide Y / Q000096:biosynthesis / Q000235:genetics; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011333:Pro-Opiomelanocortin / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D015431:Weight Loss
chemical_list: D054392:Adipokines; D019440:Anti-Obesity Agents; D001786:Blood Glucose; D018755:GABA Agonists; D058786:GABA-B Receptor Agonists; D009478:Neuropeptide Y; D012333:RNA, Messenger; D011333:Pro-Opiomelanocortin; D001418:Baclofen