title: Use of adaptive optics to determine the optimal ocular spherical aberration.
abstract: OBJECTIVE
  To explore the impact of spherical aberration (SA) on contrast sensitivity using an adaptive optics vision simulator to determine the optimal amount of SA to include in customized corrections of wavefront aberrations.
  
  
  METHODS
  Laboratorio de Optica, Universidad de Murcia, Murcia, Spain, and AMO Groningen BV, Groningen, The Netherlands.
  
  
  METHODS
  An adaptive optics vision simulator consisting of a wavefront sensor, a 97-segmented deformable mirror to induce and correct aberrations of the eye, and a visual testing path was constructed for this study. The deformable mirror allows the effective ocular wavefront aberration to be manipulated and the resulting visual performance to be measured simultaneously. Subjective measurements of contrast sensitivity at 15 cycles per degree were performed with a 4.8 mm pupil in 5 subjects with different levels of naturally occurring SA. Contrast sensitivity was measured when SA values of -0.09 microm, 0.0 microm, 0.09 microm, and 0.182 microm were induced when the other natural aberrations of the eye were present, when the aberrations were corrected, and at defocus values of +/-0.25 diopter (D) and +/-0.50 D.
  
  
  RESULTS
  Subjects experienced peak contrast sensitivity performance with varying levels of SA when their natural aberrations were present; however, average contrast performance peaked at 0 mum of SA. When all higher-order aberrations were corrected, all 5 subjects' peak performance occurred at 0 microm of SA.
  
  
  CONCLUSIONS
  The adaptive optics vision simulator reduced the root-mean-square wavefront aberration of the eye by up to a factor of 4 and allowed noninvasive testing of the visual performance resulting from any ocular wavefront aberration introduced by customized correction procedures. This study showed that, on average, contrast performance peaked when SA was completely corrected.
authors: Department of Applied Research, AMO Groningen BV, Groningen, The Netherlands. patricia.piers@amo-inc.com
authors: Patricia A
authors: PA
authors: Piers
authors: Silvestre
authors: S
authors: Manzanera
authors: Pedro M
authors: PM
authors: Prieto
authors: Nicolas
authors: N
authors: Gorceix
authors: Pablo
authors: P
authors: Artal
mesh_terms: D000328:Adult; D015350:Contrast Sensitivity / Q000502:physiology*; D006801:Humans; D007910:Lenses, Intraocular; D008954:Models, Biological; D055095:Optics and Photonics; D019591:Pseudophakia / Q000503:physiopathology*; D012030:Refractive Errors / Q000503:physiopathology*