Dental enamel dissolution after alendronate treatment.
OBJECTIVE
To evaluate the effect of treatment with a bisphosphonate (alendronate) on human dental enamel dissolution in vitro.


METHODS
The dissolution of each enamel sample was evaluated by monitoring the calcium release in 0.1M lactic acid solution at pH 4.5 (acidic solution) during dissolution tests, after topical alendronate treatment with 0.1M alendronate solutions at pH 5.0, pH 7.4 and pH 9.0.


RESULTS
Data showed that alendronate treatment, both at pH 5.0 and pH 7.4, obtained a statistically significant reduction of enamel demineralization during dissolution test reaction time (45 minutes). The protective effect was not present after treatment at pH 9.
Gandolfi
Maria G
MG
Center of Biomineralogy, Crystallography and Biomaterials, San Donato, Italy. mgiovanna.gandolfi@unibo.it
Nucci
Cesare
C
Prati
Carlo
C
Mongiorgi
Romano
R
D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects* / Q000648:ultrastructure; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000009:adverse effects; D012995:Solubility; D012996:Solutions; D017001:Tooth Demineralization / Q000139:chemically induced / Q000517:prevention & control
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D012996:Solutions; D019344:Lactic Acid