Hypothesis: myostatin is a mediator of cardiac cachexia.
Myostatin is a recently described negative regulator of skeletal muscle mass. This paper hypothesizes a role for this system in cardiac cachexia and insulin resistance and osteoporosis associated with advanced heart failure.
Hoenig
Michel R
MR
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D015992:Body Mass Index; D002100:Cachexia / Q000150:complications / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D004195:Disease Models, Animal; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007333:Insulin Resistance; D051379:Mice; D055435:Myostatin; D010024:Osteoporosis / Q000503:physiopathology; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016212:Transforming Growth Factor beta / Q000032:analysis* / Q000378:metabolism
D015415:Biomarkers; C525911:MSTN protein, human; C525912:Mstn protein, mouse; D055435:Myostatin; D016212:Transforming Growth Factor beta