Olfactory cell derivation and migration.
This special issue of the Journal of Molecular Histology is devoted to the unique phenomena of migration and adult neurogenesis observed in the olfactory system. Neural progenitors migrate from the olfactory placode and epithelium (OE) into the central nervous system (CNS) and from the forebrain ventricular region to the olfactory bulb (OB). Not unexpectedly, there are a number of controversies with regard to the mechanisms regulating these phenomena in both developing and adult animals. One especially controversial issue common to both the peripheral (OE) and central (OB) systems is the identity of the slowly dividing multipotent stem cell and the mechanisms regulating the lineage specification of these progenitors which eventually differentiate into neurons and glia. Nine contributions from leading laboratories address these and other issues with respect to progenitors and their integration into OE and OB circuitry in several species.
Puche
Adam C
AC
Department of Anatomy and Neurobiology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA. apuche@umaryland.edu
Baker
Harriet
H
D000818:Animals; D001253:Astrocytes / Q000502:physiology; D002454:Cell Differentiation; D002465:Cell Movement; D006801:Humans; D051379:Mice; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D009830:Olfactory Bulb / Q000166:cytology* / Q000196:embryology / Q000502:physiology; D009831:Olfactory Mucosa / Q000166:cytology* / Q000502:physiology; D016548:Prosencephalon / Q000196:embryology / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
D014157:Transcription Factors