title: Design and synthesis of novel multivalent mannosides targeting the mannose receptor.
abstract: According to the characteristics of C-type lectin-like domains in the mannose receptor (MR), a novel design of multivalent mannosides targeting the MR was accomplished. Beginning with a divalent mannoside as the sugar unit, a series of multivalent mannosides with variations in both valence and space were synthesized in a convergent approach. The synthetic multivalent mannosides are to be explored to study MR-sugar binding events.
authors: Department of Chemical Biology, School of Pharmaceutical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100083, PR China.
authors: Zhao-Jun
authors: ZJ
authors: Yin
authors: Qing
authors: Q
authors: Li
authors: Xiang-Bao
authors: XB
authors: Meng
authors: Zhong-Jun
authors: ZJ
authors: Li
mesh_terms: D015195:Drug Design; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism*; D008362:Mannosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D008362:Mannosides; D011956:Receptors, Cell Surface