title: Decreased heme-oxygenase (HO)-1 in the macrophages of non-small cell lung cancer.
abstract: Reactive oxygen species (ROS) are important in the initiation and promotion of cells to neoplastic growth. Heme-oxygenase (HO)-1, the inducible form of heme-oxygenase, is a cytoprotective enzyme that plays a central role in the defence against oxidative stress and is implicated in the protection of lung tissue against exogenous oxidant exposure. We investigated whether the expression of HO-1 would be decreased in lung tumour as compared with tumour-free adjacent lung tissues. HO-1 expression was quantified by immunohistochemistry in tumour macrophages, in macrophages of tumour-free lung and in tumour cells of surgical specimens collected from 53 individuals with surgically resectable non-small cell lung cancer (NSCLC). The expression of HO-1 was decreased in tumour as compared with tumour-free lung macrophages. No correlations were observed between the expression of HO-1 and both the clinicopathological characteristics and the overall survival of the examined subjects. In conclusion, our data show that macrophages of non-small cell lung cancer exhibit impaired anti-oxidant defence mechanisms, likely mediated by HO-1. Conversely, HO-1 expression does not seem to be associated with lung tumour progression and prognosis.
authors: Department of Experimental and Clinical Medicine, University of Ferrara, Ferrara, Italy. bsp@unife.it
authors: Piera
authors: P
authors: Boschetto
authors: Elena
authors: E
authors: Zeni
authors: Lucia
authors: L
authors: Mazzetti
authors: Deborah
authors: D
authors: Miotto
authors: Natalina
authors: N
authors: Lo Cascio
authors: Piero
authors: P
authors: Maestrelli
authors: Emanuela
authors: E
authors: Marian
authors: Patrizia
authors: P
authors: Querzoli
authors: Massimo
authors: M
authors: Pedriali
authors: Bruno
authors: B
authors: Murer
authors: Edoardo
authors: E
authors: De Rosa
authors: Leonardo M
authors: LM
authors: Fabbri
authors: Cristina E
authors: CE
authors: Mapp
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D051547:Heme Oxygenase-1 / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D007558:Italy / Q000453:epidemiology; D008175:Lung Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D016676:Macrophages, Alveolar / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D051547:Heme Oxygenase-1