title: An efficient and mild bismuth triflate-catalysed three-component Mannich-type reaction.
abstract: In the presence of a catalytic amount of Bi(OTf)(3).4H(2)O, aldehydes together with amines react with silyl enolates to afford the corresponding Mannich-type adducts smoothly. A wide variety of silyl enolates derived from ketones, as well as esters and thioesters, react rapidly to afford the beta-amino ketones or the beta-amino esters in high yields (up to 94%).
authors: Département de Chimie, Université Laval, Québec, Canada. thierry.ollevier@chm.ulaval.ca
authors: Thierry
authors: T
authors: Ollevier
authors: Etienne
authors: E
authors: Nadeau
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry*; D002384:Catalysis; D008698:Mesylates / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D001547:Benzaldehydes; D008698:Mesylates; D012821:Silanes; C445789:Bi(OTf)3; C023650:aniline; C032175:benzaldehyde