Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding.
Hörtner
Simone R
SR
Laboratory of Organic Chemistry, ETH Zürich, Hönggerberg, HCI, 8093 Zürich, Switzerland.
Ritschel
Tina
T
Stengl
Bernhard
B
Kramer
Christian
C
Schweizer
W Bernd
WB
Wagner
Björn
B
Kansy
Manfred
M
Klebe
Gerhard
G
Diederich
François
F
D001665:Binding Sites; D002384:Catalysis; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006860:Hydrogen Bonding; D010430:Pentosyltransferases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D012760:Shigella / Q000201:enzymology / Q000472:pathogenicity*
D004791:Enzyme Inhibitors; D010430:Pentosyltransferases; C020837:queuine tRNA-ribosyltransferase