title: Dynamic contrast-enhanced myocardial perfusion MRI accelerated with k-t sense.
abstract: In the k-t sensitivity encoding (k-t SENSE) method spatiotemporal data correlations are exploited to accelerate data acquisition in dynamic MRI studies. The present study demonstrates the feasibility of applying k-t SENSE to contrast-enhanced myocardial perfusion MRI and using the speed-up to increase spatial resolution. At a net acceleration factor of 3.9 (k-t factor of 5 with 11 training profiles) accurate representations of dynamic signal intensity (SI) changes were achieved in computer simulations. In vivo, 5x k-t SENSE was compared with 2x SENSE (identical acquisition parameters except for in-plane spatial resolution = 1.48 x 1.48 mm(2) vs. 2.64 x 2.64 mm(2), respectively). In 10 volunteers no differences in myocardial SI profiles were found (relative peak enhancement = 151% vs. 149.7%, maximal upslope = 12.9%/s vs. 13.3%/s for 2x SENSE and 5x k-t SENSE, respectively, all P > 0.05). Overall image quality was similar, but endocardial dark rim artifacts were reduced with k-t SENSE. Signal-to-noise ratio (SNR) in the myocardium was greater with 5x k-t SENSE by a factor of 1.36 +/- 0.23 at peak contrast enhancement with the relative yield decreasing with increasing dynamics in the object in accordance to theory. Higher nominal acceleration factors of up to 10-fold were shown to be feasible in computer simulations and in vivo.
authors: Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland. s.plein@leeds.ac.uk
authors: Sven
authors: S
authors: Plein
authors: Salome
authors: S
authors: Ryf
authors: Juerg
authors: J
authors: Schwitter
authors: Aleksandra
authors: A
authors: Radjenovic
authors: Peter
authors: P
authors: Boesiger
authors: Sebastian
authors: S
authors: Kozerke
mesh_terms: D000328:Adult; D016477:Artifacts; D003198:Computer Simulation; D003327:Coronary Disease / Q000175:diagnosis; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged