Lichenoid drug eruption of nails induced by propylthiouracil.
We present the case of a patient who developed deformities of the fingernails and reddish nodules on the nail beds after administration of propylthiouracil (PTU) for 6 months to treat Grave's disease. Histological examination of the lesion revealed a lichenoid tissue reaction. After withdrawal of PTU, she noticed an improvement in the eruption and the growth of the nails. No recurrence of the eruption was detected after the withdrawal of PTU. Thus, we strongly suggest that this was a rare case of PTU-induced lichenoid drug eruption of nail.
Saito
Marumi
M
Department of Dermatology, School of Medicine, Fukushima Medical University, Fukushima City, Fukushima Prefecture, Japan. t-marumi@fmu.ac.jp
Nakamura
Koichiro
K
Kaneko
Fumio
F
D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D020405:Dermis / Q000473:pathology; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D017512:Lichenoid Eruptions / Q000139:chemically induced* / Q000473:pathology; D009260:Nail Diseases / Q000139:chemically induced* / Q000473:pathology; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use
D013956:Antithyroid Agents; D011441:Propylthiouracil