title: Assessment of quality of life in HAART-treated HIV-positive subjects with body fat redistribution in Rwanda.
abstract: BACKGROUND
  The introduction of HAART has initially improved the quality of life (QoL) of HIV-positive (HIV+) patients, however body fat redistribution (BFR) and metabolic disorders associated with long-term HAART use may attenuate this improvement. As access to treatment improves in sub-Saharan Africa, the disfiguring nature of BFR (peripheral atrophy and/or central adiposity) may deter treatment adherence and initiatives and decrease QoL. We examined the relationship between BFR and domains of QoL in HAART-treated HIV+ African men and women with (HIV+BFR, n = 50) and without (HIV+noBFR, n = 50) BFR in Rwanda.
  
  
  RESULTS
  HIV+ subjects with BFR were less satisfied with their body image (4.3 +/- 0.1 versus 1.5 +/- 0.2; p < .001), self-esteem and social life (4.1 +/- 1.4 versus 2.1 +/- 0.3; p = 0.003). HIV+BFR were more ashamed in public (4.5 +/- 1.2 versus 1.1 +/- 1.1), reported less confident about their health (4.6 +/- 1.4 versus 1.5 +/- 1.2) and were frequently embarrassed due to body changes (4.1 +/- 1.1 versus 1.1 +/- 0.9) (p < .001) than HIV+noBFR. HIV+ Rwandan women with BFR reported more dissatisfaction with psychological (8.3 +/- 2.9 versus 13.7 +/- 1.9), social relationships (6.9 +/- 2.3 versus 11.1 +/- 4.1) and HIV HAART-specific domain of wellbeing (3.1 +/- 4.8 versus 6.3 +/- 3.6) (p < .001). Age was associated with independence (r2 = 0.691; p = 0.009) and marital status was associated with psychological (r2 = 0.593; p = 0.019) and social relationships (r2 = 0.493; p = 0.007). CD4 count (r2 = 0.648; p = 0.003) and treatment duration (r2 = 0.453; p = 0.003) were associated with HIV HAART-specific domain of wellbeing. HIV+ Rwandan women with BFR were significantly more affected by abdominal adiposity (p < .001), facial and buttocks atrophy (p < .05) than HIV+ men with BFR.
  
  
  CONCLUSIONS
  Body fat alterations negatively affect psychological and social domains of quality of life. These symptoms may result in stigmatization and marginalization mainly in HAART-treated African women, adversely affecting HAART adherence and treatment initiatives. Efforts to evaluate self-perceived body fat changes may improve patients' wellbeing, HAART adherence and treatment outcomes and contribute towards stability in quality of life continuum.
authors: Faculty of Allied Health Sciences & Programs in HIV/AIDS Clinical Research and Community Interventions, Kigali Health Institute, B, P 3286 Kigali, Rwanda. eumuran@yahoo.co.uk
authors: Eugene
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