title: Effect of host selective pressure on Newcastle disease virus virulence.
abstract: Newcastle disease virus (NDV) causes an economically important disease that can vary from clinically inapparent to highly virulent forms. Generally, NDV strains isolated from wild birds are non-pathogenic for chicken. However, there are evidences supporting the fact that avirulent viruses maintained in feral birds could have caused outbreaks of virulent NDV in poultry. The strain-specific difference in virulence is determined by structural variations on the fusion glycoprotein (F). More basic amino acids are present in the F cleavage site of virulent strains. Nevertheless, other regions have been involved in virulence determination. When we subjected an avirulent NDV isolated from a wild bird to a host change we found that the virus arose was virulent for chicken. Nucleotide changes in the F protein cleavage site amino acid sequence and in the hemagglutinin-neuraminidase protein sequence are reported.
authors: Instituto de Biotecnología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, Instituto Nacional de Tecnología Agropecuaria, Las Cabañas y Los Reseros s/n, Hurlingham, Buenos Aires, Argentina. fzanetti@cnia.inta.gov.ar
authors: Flavia
authors: F
authors: Zanetti
authors: Analía
authors: A
authors: Berinstein
authors: Elisa
authors: E
authors: Carrillo
mesh_terms: D000818:Animals; D001717:Birds; D002642:Chick Embryo; D002645:Chickens; D004252:DNA Mutational Analysis; D015707:HN Protein / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D009521:Newcastle Disease / Q000821:virology*; D009522:Newcastle disease virus / Q000254:growth & development* / Q000472:pathogenicity; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D014760:Viral Fusion Proteins / Q000235:genetics; D015678:Viral Structural Proteins / Q000235:genetics; D014774:Virulence / Q000235:genetics
chemical_list: D015707:HN Protein; D014760:Viral Fusion Proteins; D015678:Viral Structural Proteins