Potential applications of biphosphonates in dental surgical implants.
Biphosphonates are largely used for their unquestionable properties of inhibiting bone resorption by osteoclasts in the treatment of various osteometabolic illnesses such as osteoporosis, multiple myeloma, tumors which metastasize to the bone and malignant hypercalcemia. In this literature review the physico-chemical properties, biologic activities and the mechanisms of action of biphosphonates are described. The use of these drugs is discussed, analyzing the quantity of results which have emerged through in vitro and in vivo experiments on animal models. In this study the efficiency of these drugs is demonstrated in contrasting the osteolitic processes of the alveolar bone, in promoting the neoformation and in bettering the quality of bone implants. However, it is important to draw attention to a worrying correlation which has emerged during the last 3-4 years, between osteonecrosis of the jaw (ONJ) and the systemic administration of aminobiphosphonates. This collateral effect did not emerge following the use of non-aminobiphosphonates. The aim of this review is to identify the guidelines for the use of biphosphonates in oral implant surgery.
Berardi
D
D
Department of Oral Sciences, University G. D'Annunzio, Chieti, Chieti, Italy.
Carlesi
T
T
Rossi
F
F
Calderini
M
M
Volpi
R
R
Perfetti
G
G
D016301:Alveolar Bone Loss / Q000517:prevention & control*; D000818:Animals; D015921:Dental Implants; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D016348:Osseointegration / Q000187:drug effects*; D010020:Osteonecrosis / Q000139:chemically induced
D015921:Dental Implants; D004164:Diphosphonates