Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.
We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer's disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice.
Nakajima
Akira
A
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Yamakuni
Tohru
T
Haraguchi
Mitsuya
M
Omae
Naoki
N
Song
Si-Young
SY
Kato
Chieko
C
Nakagawasai
Osamu
O
Tadano
Takeshi
T
Yokosuka
Akihito
A
Mimaki
Yoshihiro
Y
Sashida
Yutaka
Y
Ohizumi
Yasushi
Y
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002957:Citrus / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy*; D051379:Mice; D008953:Models, Anatomic; D015394:Molecular Structure; D009410:Nerve Degeneration / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D009830:Olfactory Bulb / Q000503:physiopathology / Q000601:surgery*
D000975:Antioxidants; D047309:Flavones; D005419:Flavonoids; C008661:nobiletin; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase