title: Olfactory function and nasal nitric oxide.
abstract: OBJECTIVE
  To determine the relationship between nasal nitric oxide (nNO) concentration and its influence on olfactory function.
  
  
  METHODS
  Tertiary otolaryngology care centre.
  
  
  METHODS
  Sixty-four patients suffering from chronic rhinosinusitis and 20 healthy subjects participated.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  The nNO concentration was measured by chemiluminescence and olfactory thresholds were measured with the phenyl ethanol threshold of the Sniffin' Sticks. In chronic rhinosinusitis patients this measure was done preoperatively and 3 months after endoscopic sinus surgery.
  
  
  RESULTS
  Healthy subjects had significantly higher nNO concentrations and better olfactory thresholds compared to the chronic rhinosinusitis patients, both before and after those had undergone sinus surgery. Olfactory thresholds and nNO concentrations remained unchanged after surgery in the chronic rhinosinusitis group. In the chronic rhinosinusitis group, nNO concentrations correlated positively with the olfactory threshold preoperatively (P < 0.0001) and 3 months after surgery (P < 0.05). In the control group, nNO production did not correlate with the olfactory thresholds (P > 0.05).
  
  
  CONCLUSIONS
  Olfactory function and nNO concentration correlate in chronic rhinosinusitis patients but not in healthy subjects. This suggests that both parameters do rather not directly influence each other but it might be the inflammatory processes found in chronic rhinosinusitis that affects olfaction and nNO. Nasal nitric oxide produced by the paranasal sinuses seems not to directly influence olfactory function.
authors: Department of Otolaryngology Head and Neck Surgery, Tanta University, Tanta, Egypt.
authors: H S
authors: HS
authors: Elsherif
authors: B N
authors: BN
authors: Landis
authors: M H
authors: MH
authors: Hamad
authors: M
authors: M
authors: Hugentobler
authors: S M
authors: SM
authors: Bahig
authors: A M
authors: AM
authors: Gamaa
authors: J S
authors: JS
authors: Lacroix
mesh_terms: D000328:Adult; D000368:Aged; D001944:Breath Tests / Q000379:methods; D002908:Chronic Disease; D004724:Endoscopy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D009832:Olfactory Nerve / Q000503:physiopathology*; D011446:Prospective Studies; D012220:Rhinitis / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D012720:Severity of Illness Index; D012852:Sinusitis / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D012903:Smell / Q000502:physiology*
chemical_list: D009569:Nitric Oxide