title: Compartmental loss of striatal medium spiny neurons in multiple system atrophy of parkinsonian type.
abstract: Topographical or compartmental involvement of the putamen and caudate nucleus has not been fully elucidated in multiple system atrophy predominantly presenting with Parkinsonism (MSA-P). We carried out immunohistochemical studies using antibodies to calbindin (CALB) and calcineurin (CaN) as neurochemical markers for striatal medium spiny neurons. We found that in the caudal and dorsolateral putamen, the area most affected in MSA-P, the medium spiny neurons positive for CALB were severely depleted, while CaN-positive neurons were relatively spared in a mosaic pattern. In the dorsal caudate nucleus, an area less affected in MSA, residual CALB-positive neurons exhibited a compartmentalized distribution that corresponded with the striosomal arrangement visualized by Met-enkephalin immunostaining. Our findings suggest that there is a compartmental difference in the susceptibility of striatal medium spiny neurons to neurodegeneration in MSA-P.
authors: Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima, Japan.
authors: Kenta
authors: K
authors: Sato
authors: Ryuji
authors: R
authors: Kaji
authors: Sadayuki
authors: S
authors: Matsumoto
authors: Shinji
authors: S
authors: Nagahiro
authors: Satoshi
authors: S
authors: Goto
mesh_terms: D000368:Aged; D001344:Autopsy; D001921:Brain / Q000473:pathology; D064026:Calbindins; D019703:Calcineurin / Q000378:metabolism; D002421:Caudate Nucleus / Q000473:pathology; D002452:Cell Count; D004744:Enkephalin, Methionine / Q000378:metabolism; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000378:metabolism / Q000473:pathology*; D017072:Neostriatum / Q000378:metabolism / Q000473:pathology*; D009410:Nerve Degeneration / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D020734:Parkinsonian Disorders / Q000378:metabolism / Q000473:pathology*; D011699:Putamen / Q000473:pathology; D064030:S100 Calcium Binding Protein G / Q000378:metabolism
chemical_list: D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D004744:Enkephalin, Methionine; D019703:Calcineurin