Polymers in the prevention of peritoneal adhesions.
Peritoneal adhesions are serious complications of surgery, and can result in pain, infertility, and potentially lethal bowel obstruction. Pharmacotherapy and barrier devices have reduced adhesion formation to varying degrees in preclinical studies or clinical trials; however, complete prevention of adhesions remains to be accomplished. We and others have hypothesized that the limitations of the two approaches could be overcome by combining their strengths in the context of controlled drug delivery. Here we review the role of polymeric systems in the prevention of peritoneal adhesions, with an emphasis on our recent work in developing and applying polymeric drug delivery systems such as nano- or microparticles, hydrogels, and hybrid systems for peritoneal use.
Yeo
Yoon
Y
School of Pharmacy and Pharmaceutical Sciences, Weldon School of Biomedical Engineering, Purdue University, West Lafayelte IN, USA.
Kohane
Daniel S
DS
D000818:Animals; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D010537:Peritoneum / Q000187:drug effects / Q000473:pathology*; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers