RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection.
Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.
Cirioni
Oscar
O
Institute of Infectious Diseases and Public Health, Polytechnic University of the Marche Region, A.O. Ospedali Riuniti, Ancona, Italy. anconacmi@interfree.it
Ghiselli
Roberto
R
Minardi
Daniele
D
Orlando
Fiorenza
F
Mocchegiani
Federico
F
Silvestri
Carmela
C
Muzzonigro
Giovanni
G
Saba
Vittorio
V
Scalise
Giorgio
G
Balaban
Naomi
N
Giacometti
Andrea
A
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D004195:Disease Models, Animal; D005260:Female; D010455:Peptides / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D015607:Stents / Q000382:microbiology*; D017334:Teicoplanin / Q000494:pharmacology; D014513:Ureter / Q000601:surgery
D000900:Anti-Bacterial Agents; D010455:Peptides; D012329:RNA, Bacterial; C096035:RNAIII, Staphylococcus aureus; D017334:Teicoplanin