Novel drug resistance pattern associated with the mutations K70G and M184V in human immunodeficiency virus type 1 reverse transcriptase.
We describe an unusual pathway of human immunodeficiency virus type 1 reverse transcriptase resistance during therapy with tenofovir-emtricitabine, characterized initially by the mutations K70E and M184V and later by K70G and M184V, with the two mutations coexisting on the same viral genome. Phenotypic resistance to lamivudine, emtricitabine, abacavir, didanosine, and tenofovir was observed, whereas susceptibility to zidovudine and stavudine was preserved.
Bradshaw
D
D
Department of Virology, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom.
Malik
S
S
Booth
C
C
Van Houtte
M
M
Pattery
T
T
Waters
A
A
Ainsworth
J
J
Geretti
A M
AM
D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D019943:Amino Acid Substitution / Q000235:genetics*; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000494:pharmacology; D016049:Didanosine / Q000494:pharmacology; D015224:Dideoxynucleosides / Q000494:pharmacology; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics*; D000068679:Emtricitabine; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D006801:Humans; D019259:Lamivudine / Q000494:pharmacology; D008969:Molecular Sequence Data; D009154:Mutation; D063065:Organophosphonates / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*; D018119:Stavudine / Q000494:pharmacology; D000068698:Tenofovir; D015215:Zidovudine / Q000494:pharmacology; D000099227:Abacavir
D000225:Adenine; D003841:Deoxycytidine; D016049:Didanosine; D015224:Dideoxynucleosides; D000068679:Emtricitabine; D054303:HIV Reverse Transcriptase; D019259:Lamivudine; D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D018119:Stavudine; D000068698:Tenofovir; D015215:Zidovudine; D000099227:Abacavir; C514824:reverse transcriptase, Human immunodeficiency virus 1