title: Vertical alveolar ridge augmentation using autogenous bone grafts and platelet-enriched fibrin glue with simultaneous implant placement.
abstract: OBJECTIVE
  The aim of this study was to evaluate the combined use of autogenous bone and platelet-enriched fibrin glue as grafting material for vertical alveolar ridge augmentation with simultaneous implant placement in a canine alveolar ridge defect model.
  
  
  METHODS
  In 6 mongrel dogs, bilateral vertical alveolar ridge defects were created in the mandible. After 3 months of healing, 2 dental implants were placed in each defect of the mandible, creating 6-mm supra-alveolar peri-implant defects. The 2 implants per defect were subjected to surgical treatments involving either a combination of autogenous bone grafts and platelet-enriched fibrin glue, or a conventional flap procedure only (control). After a healing period of 6 months, the dogs were humanely killed for histological and histometric analyses.
  
  
  RESULTS
  Implant placement alone produced limited vertical alveolar height (0.6 +/- 0.4 mm). However, alveolar augmentation including a combination of autogenous bone grafts and platelet-enriched fibrin glue with simultaneous implant placement resulted in alveolar ridge augmentation amounting to 4.2 +/- 1.0 mm, comprising 63% of the defect height. New bone-implant contact was 40.5% in the defects treated with combined autogenous bone grafts and platelet-enriched fibrin glue, and was 48.4% in the resident bone; this difference was not statistically significant.
  
  
  CONCLUSIONS
  The present study demonstrates that vertical alveolar ridge augmentation using autogenous bone grafts and platelet-enriched fibrin glue with simultaneous implant placement might effectively increase vertical alveolar ridge height and allow for an acceptable level of osseointegration.
authors: Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea.
authors: Hyeon-Jung
authors: HJ
authors: Lee
authors: Byung-Ho
authors: BH
authors: Choi
authors: Jae-Hyung
authors: JH
authors: Jung
authors: Shi-Jiang
authors: SJ
authors: Zhu
authors: Seoung-Ho
authors: SH
authors: Lee
authors: Jin-Young
authors: JY
authors: Huh
authors: Tae-Min
authors: TM
authors: You
authors: Jingxu
authors: J
authors: Li
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001792:Blood Platelets; D016025:Bone Transplantation / Q000379:methods*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D004285:Dogs; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000737:chemistry / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000737:chemistry / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives