Cervical cancer associated with pregnancy: results of a multicenter retrospective Korean study (KGOG-1006).
OBJECTIVE
The objective of the study was to analyze the characteristics of cervical cancer associated with pregnancy.


METHODS
Forty patients with cervical cancer associated with pregnancy were retrospectively identified between 1995-2003. Three controls for each case were matched on the basis of age, stage, histology, and date of treatment.


RESULTS
Sampling of cervical cytology after the second trimester was the most common cause of delayed diagnosis. Among 12 patients who delayed treatment for fetal maturity, 2 died of disease. There was no difference in overall survival between pregnant and nonpregnant patients with stage Ib tumors. In contrast to nonpregnant patients, the depth of stromal invasion was not correlated with the incidence of lymph vascular space involvement and lymph node metastasis in pregnant patients.


CONCLUSIONS
Thorough evaluation is warranted before deciding whether to delay treatment until fetal maturity. Pregnancy does not adversely affect the prognosis of early-stage cervical cancer significantly.
Lee
Jong-Min
JM
Department of Obstetrics and Gynecology, East-West Neo Medical Center, Kyung Hee University, Seoul, Korea.
Lee
Kwang-Beom
KB
Kim
Young-Tak
YT
Ryu
Hee-Sug
HS
Kim
Young-Tae
YT
Cho
Chi-Heum
CH
Namkoong
Sung-Eun
SE
Lee
Ki-Hun
KH
Choi
Ho-Sun
HS
Kim
Kyung-Tai
KT
D000328:Adult; D017677:Age Distribution; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D015897:Comorbidity; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D008875:Middle Aged; D009367:Neoplasm Staging; D011181:Postnatal Care / Q000379:methods; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy