title: Combinatorial Knoevenagel reactions.
abstract: Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the Knoevenagel condensations of aromatic aldehydes with various methylene active compounds. High yields and a simple workup of target compounds enables the facile generation of combinatorial libraries comprising 11,000 compounds of high structural and functional diversity.
authors: Enamine Ltd., 23 A. Matrosova st., 01103 Kyiv, Ukraine. Ryabukhin@mail.enamine.net
authors: Sergey V
authors: SV
authors: Ryabukhin
authors: Andrey S
authors: AS
authors: Plaskon
authors: Dmitriy M
authors: DM
authors: Volochnyuk
authors: Sergey E
authors: SE
authors: Pipko
authors: Alexander N
authors: AN
authors: Shivanyuk
authors: Andrey A
authors: AA
authors: Tolmachev
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D008956:Models, Chemical; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic