title: Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families.
abstract: BACKGROUND
  Atopic dermatitis develops as a result of complex interactions between several genetic and environmental factors. To date, 4 genome-wide linkage studies of atopic dermatitis have been performed in Caucasian populations, however, similar studies have not been done in Asian populations. The aim of this study was to identify chromosome regions linked to atopic dermatitis in a Japanese population.
  
  
  METHODS
  We used a high-density, single nucleotide polymorphism genotyping assay, the Illumina BeadArray Linkage Mapping Panel (version 4) comprising 5,861 single nucleotide polymorphisms, to perform a genome-wide linkage analysis of 77 Japanese families with 111 affected sib-pairs with atopic dermatitis.
  
  
  RESULTS
  We found suggestive evidence for linkage with 15q21 (LOD = 2.01, NPL = 2.87, P = .0012) and weak linkage to 1q24 (LOD = 1.26, NPL = 2.44, P = .008).
  
  
  CONCLUSIONS
  We report the first genome-wide linkage study of atopic dermatitis in an Asian population, and novel loci on chromosomes 15q21 and 1q24 linked to atopic dermatitis. Identification of novel causative genes for atopic dermatitis will advance our understanding of the pathogenesis of atopic dermatitis.
authors: Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan. ch0205531@md.tsukuba.ac.jp
authors: Hisako
authors: H
authors: Enomoto
authors: Emiko
authors: E
authors: Noguchi
authors: Shigeruko
authors: S
authors: Iijima
authors: Takenori
authors: T
authors: Takahashi
authors: Kazuhito
authors: K
authors: Hayakawa
authors: Mikako
authors: M
authors: Ito
authors: Toshiyuki
authors: T
authors: Kano
authors: Takeshi
authors: T
authors: Aoki
authors: Yoichi
authors: Y
authors: Suzuki
authors: Minori
authors: M
authors: Koga
authors: Mayumi
authors: M
authors: Tamari
authors: Tetsuo
authors: T
authors: Shiohara
authors: Fujio
authors: F
authors: Otsuka
authors: Tadao
authors: T
authors: Arinami
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D003876:Dermatitis, Atopic / Q000208:ethnology* / Q000235:genetics*; D005192:Family Health; D005260:Female; D023281:Genomics; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide