title: Survival of parents and siblings of supercentenarians.
abstract: BACKGROUND
  Given previous evidence of familial predisposition for longevity, we hypothesized that siblings and parents of supercentenarians (age >or= 110 years) were predisposed to survival to very old age and that, relative to their birth cohorts, their relative survival probabilities (RSPs) are even higher than what has been observed for the siblings of centenarians.
  
  
  METHODS
  Mean age at death conditional upon survival to ages 20 and 50 and survival probabilities from ages 20 and 50 to higher ages were determined for 50 male and 56 female siblings and 54 parents of 29 supercentenarians. These estimates were contrasted with comparable estimates based on birth cohort-specific mortality experience for the United States and Sweden.
  
  
  RESULTS
  Conditional on survival to age 20 years, mean age at death of supercentenarians' siblings was approximately 81 years for men and women. Compared with respective Swedish and U.S. birth cohorts, these estimates were 17%-20% (12-14 years) higher for the brothers and 11%-14% (8-10 years) higher for the sisters. Sisters had a 2.9 times greater probability and brothers had a 4.3 times greater probability of survival from age 20 to age 90. Mothers of supercentenarians had a 5.8 times greater probability of surviving from age 50 to age 90. Fathers also experienced an increased survival probability from age 50 to age 90 of 2.7, but it failed to attain statistical significance.
  
  
  CONCLUSIONS
  The RSPs of siblings and mothers of supercentenarians revealed a substantial survival advantage and were most pronounced at the oldest ages. The RSP to age 90 for siblings of supercentenarians was approximately the same as that reported for siblings of centenarians. It is possible that greater RSPs are observed for reaching even higher ages such as 100 years, but a larger sample of supercentenarians and their siblings and parents is needed to investigate this possibility.
authors: New England Centenarian Study, Geriatrics Section, Boston Medical Center, 88 East Newton St., Boston, MA 02118, USA. thperls@bu.edu
authors: Thomas
authors: T
authors: Perls
authors: Iliana V
authors: IV
authors: Kohler
authors: Stacy
authors: S
authors: Andersen
authors: Emily
authors: E
authors: Schoenhofen
authors: JaeMi
authors: J
authors: Pennington
authors: Robert
authors: R
authors: Young
authors: Dellara
authors: D
authors: Terry
authors: Irma T
authors: IT
authors: Elo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over / Q000706:statistics & numerical data*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010290:Parents; D035781:Siblings; D013548:Sweden / Q000453:epidemiology; D014481:United States / Q000453:epidemiology