Synthesis and biological activity of 3-(2, 8, 9-trioxa-aza-1-germatricyclo [3. 3. 3. 0]undecane-1-yl)-hydroxycinnamic acids.
The new germanium compounds of cinnamic acid, RC(6)H(4)CHGe(OCH(2)CH(2))(3)NCH(2)COOH R=H (I), 2-OH (II), 3-OH (III), 4-OH (IV), have been obtained to study anti-tumor activities. Compounds (I-IV) were prepared by the electrophilic addition reaction and nucleophilic substitution reaction. Biological investigation has demonstrated that all compounds (I-IV) are lower toxicity with strongly anti-tumor activity than positive control.
Ye
Lianbao
L
Medicinal Chemistry Department, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China. ywpl110@163.com
Zhang
Wanjin
W
D003373:Coumaric Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy
D003373:Coumaric Acids