Design and synthesis of novel multivalent mannosides targeting the mannose receptor.
According to the characteristics of C-type lectin-like domains in the mannose receptor (MR), a novel design of multivalent mannosides targeting the MR was accomplished. Beginning with a divalent mannoside as the sugar unit, a series of multivalent mannosides with variations in both valence and space were synthesized in a convergent approach. The synthetic multivalent mannosides are to be explored to study MR-sugar binding events.
Yin
Zhao-Jun
ZJ
Department of Chemical Biology, School of Pharmaceutical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100083, PR China.
Li
Qing
Q
Meng
Xiang-Bao
XB
Li
Zhong-Jun
ZJ
D015195:Drug Design; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism*; D008362:Mannosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*
D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D008362:Mannosides; D011956:Receptors, Cell Surface