title: [The mechanism of DNA damage checkpoint control].
abstract: DNA damage caused by many factors may lead to missense mutation, deletion or illegal recombination. To maintain genomic integrity, cells have evolved complex surveillance mechanisms termed cell cycle checkpoint. DNA damage checkpoint composed of various checkpoint-related proteins can sense DNA damage and execute cell cycle arrest through different signaling transduction pathway involving protein kinase cascades, thereby allowing time for cells to repair the damaged DNA.
authors: Medical Research Center, Third Hospital of Peking University, Beijing 100083, China.
authors: Yan-Hong
authors: YH
authors: Guo
authors: Ying-Bao
authors: YB
authors: Zhu
mesh_terms: D000818:Animals; D059447:Cell Cycle Checkpoints / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D011494:Protein Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D011494:Protein Kinases