DNA cleavage by photolysis of aryl sulfoxides.
Aryl sulfoxides have been identified as a class of organic compounds capable of inducing DNA cleavage in the presence of UV light. Phenyl sulfoxide and methyl phenyl sulfoxide were both shown to cleave pBR322 DNA at concentrations of 180 and 360 microM, respectively. Radical trapping studies indicate carbon-centered radicals are the active cleavage species.
Mayo
Daniel J
DJ
Department of Chemistry, Shippensburg University, Shippensburg, PA 17257, USA.
Turner
David P
DP
Zucconi
Beth E
BE
Predecki
Allison H
AH
D001555:Benzene Derivatives / Q000737:chemistry / Q000528:radiation effects; D053837:DNA Cleavage / Q000528:radiation effects*; D005609:Free Radicals / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010782:Photolysis; D013454:Sulfoxides / Q000737:chemistry* / Q000528:radiation effects*; D014466:Ultraviolet Rays
D001555:Benzene Derivatives; D005609:Free Radicals; D013454:Sulfoxides; C417240:methyl phenyl sulfoxide; C048860:diphenyl sulfoxide