title: Effect of selenium- and glutathione-enriched yeast supplementation on a combined atherosclerosis and diabetes hamster model.
abstract: Selenium has a central role in antioxidant pathways as a cofactor to glutathione peroxidase. The present study evaluated the effects of four different preparations of inactivated yeast containing various concentrations of selenium and glutathione on a combined atherosclerosis and diabetes hamster model. The hamsters were supplemented with the yeast products for three months. The enriched yeast with the highest selenium and glutathione levels reduced the weight loss induced by diabetes, inhibited an increase in plasma cholesterol and triglyceride caused by a high-cholesterol and high-fat diet, increased the time taken for oxidation of lower density lipoproteins (lag time), and inhibited the formation of atherosclerosis better than low selenium/glutathione yeast supplementation. It was concluded that the yeast prepared to provide high selenium and high glutathione was the best for effecting beneficial changes in glutathione, cholesterol, atherosclerosis, and for demonstrating an antioxidant effect. The high selenium and low glutathione yeast was the best for improving selenium and glucose levels.
authors: Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510, USA. agogae@yahoo.fr
authors: Gabriel A
authors: GA
authors: Agbor
authors: Joe A
authors: JA
authors: Vinson
authors: Shachi
authors: S
authors: Patel
authors: Kunal
authors: K
authors: Patel
authors: Jenyne
authors: J
authors: Scarpati
authors: Drew
authors: D
authors: Shiner
authors: Forbes
authors: F
authors: Wardrop
authors: Thomas A
authors: TA
authors: Tompkins
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000628:therapy*; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000628:therapy*; D019587:Dietary Supplements; D005978:Glutathione / Q000008:administration & dosage* / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008647:Mesocricetus; D019936:Probiotics; D012441:Saccharomyces cerevisiae / Q000737:chemistry; D012643:Selenium / Q000008:administration & dosage* / Q000097:blood
chemical_list: D008055:Lipids; D005978:Glutathione; D012643:Selenium