Microwave-assisted synthesis, characterization and biological screening of nitrogen-sulphur and nitrogen-oxygen donor ligands and their organotin(IV) complexes.
Series of new trigonal bipyramidal and octahedral complexes of tin(IV) have been synthesized by the reaction of dimethyltin(IV) dichloride with 4-nitro-benzanilidethiosemicarbazone (L(1)H), 4-chlorobenzanilidethiosemicarbazone (L(2)H), 4-nitrobenzanilidesemicarbazone (L(3)H) and 4-chlorobenzanilidesemicarbazone (L(4)H). The unimolecular and bimolecular reactions of dimethyltin(IV) dichloride and monobasic bidentate ligands were carried out using microwave irradiations as the thermal energy source and the complexes so formed were characterized by elemental analysis, conductance measurements, molecular weight determinations and spectral data, viz. IR, UV-vis, (1)H and (13)C NMR. The complexes have also been prepared by the general thermal methods for comparison purposes. The comparison data support the synthesis using the microwave route, i.e. green chemistry route. The tin(IV) complexes show penta-coordinated structure for 1:1 complexes and hexa-coordinated for 1:2 complexes. The antifungal, antibacterial and antifertility activities have been examined and the results were indeed very encouraging.
Singh
R V
RV
Department of Chemistry, University of Rajasthan, Jaipur 302004, India. rvsjpr@hotmail.com
Chaudhary
Pratibha
P
Poonia
Kavita
K
Chauhan
Shikha
S
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D004602:Elements; D005658:Fungi / Q000187:drug effects; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D009584:Nitrogen / Q000737:chemistry*; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010100:Oxygen / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared; D013094:Spermatozoa / Q000187:drug effects; D013455:Sulfur / Q000737:chemistry*
D004602:Elements; D008024:Ligands; D009947:Organotin Compounds; D013455:Sulfur; D009584:Nitrogen; D010100:Oxygen