Combinatorial Knoevenagel reactions.
Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the Knoevenagel condensations of aromatic aldehydes with various methylene active compounds. High yields and a simple workup of target compounds enables the facile generation of combinatorial libraries comprising 11,000 compounds of high structural and functional diversity.
Ryabukhin
Sergey V
SV
Enamine Ltd., 23 A. Matrosova st., 01103 Kyiv, Ukraine. Ryabukhin@mail.enamine.net
Plaskon
Andrey S
AS
Volochnyuk
Dmitriy M
DM
Pipko
Sergey E
SE
Shivanyuk
Alexander N
AN
Tolmachev
Andrey A
AA
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D008956:Models, Chemical; D013237:Stereoisomerism
D000447:Aldehydes; D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic