Insulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adults.
Increasing evidence suggests that the insulin-like growth factor (IGF)-axis may play a role in glucose metabolism and may also be associated with systemic inflammation. The aim of this study was to evaluate the association of insulin-like growth factor-1 (IGF-I) and its binding proteins, IGFBP-1 and IGFBP-3, with glucose intolerance and inflammation among older adults. We conducted a cross-sectional analysis in a in a random subsample (n=922) of the Cardiovascular Health Study (CHS), a prospective cohort of men and women > or = 65 years. Mean IGFBP-1 levels were significantly lower in older adults with impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and diabetes compared to those with normal fasting and post-load glucose. High IGFBP-1 was associated with a reduced prevalence of IGT and IFG; the multivariable OR between extreme quartiles of IGFBP-1 was 0.60 (95% CI: 0.37, 0.95; p-trend: 0.03) for IGT and 0.41 (95% CI: 0.26, 0.64; p-trend: <0.01) for IFG. We did not find any significant association between IGF-I and glucose intolerance in this study and the association for IGFBP-3 was less clear. However, low levels of IGF-I and IGFBP-3 were associated with increased levels of markers of inflammation including C-reactive protein and interleukin-6 levels. We conclude that among adults > or = 65 years, low IGFBP-1 levels are associated with increased prevalence of glucose intolerance. We did not confirm prior associations of low IGF-I with glucose intolerance in this cohort of older individuals.
Rajpathak
Swapnil N
SN
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 11375, USA. srajpath@aecom.yu.edu
McGinn
Aileen P
AP
Strickler
Howard D
HD
Rohan
Thomas E
TE
Pollak
Michael
M
Cappola
Anne R
AR
Kuller
Lewis
L
Xue
XiaoNan
X
Newman
Anne B
AB
Strotmeyer
Elsa S
ES
Psaty
Bruce M
BM
Kaplan
Robert C
RC
D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000453:epidemiology*; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood; D008297:Male; D015398:Signal Transduction / Q000502:physiology; D013002:Somatomedins / Q000032:analysis* / Q000378:metabolism
D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins