Optic nerve dysfunction in a child following low-dose maternal warfarin exposure.
Because the embryopathy associated with maternal warfarin use seems dose-dependent, some physicians advocate low-dose warfarin for pregnant women requiring anticoagulation. The current case, however, highlights that optic nerve dysfunction (as well as other signs of warfarin embryopathy) can occur after low-dose maternal warfarin exposure.
Khan
Arif O
AO
Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. arif.khan@mssm.edu
D000014:Abnormalities, Drug-Induced; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005145:Face / Q000002:abnormalities; D005260:Female; D006801:Humans; D007223:Infant; D009264:Nails, Malformed / Q000139:chemically induced / Q000473:pathology; D009901:Optic Nerve Diseases / Q000139:chemically induced*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy; D011261:Pregnancy Trimester, First; D011297:Prenatal Exposure Delayed Effects; D020246:Venous Thrombosis / Q000188:drug therapy; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D000925:Anticoagulants; D014859:Warfarin