title: Babies born after ART treatment cost more than non-ART babies: a cost analysis of inpatient birth-admission costs of singleton and multiple gestation pregnancies.
abstract: BACKGROUND
  Currently, about one-third of infants born after assisted reproductive technology (ART) worldwide are twins or triplets. This study compared the inpatient birth-admission costs of singleton and multiple gestation ART deliveries to non-ART deliveries.
  
  
  METHODS
  A cohort of 5005 mothers and 5886 infants conceived following ART treatment were compared to 245 249 mothers and 248 539 infants in the general population. Birth-admission costs were calculated using Australian Refined Diagnosis Related Groups and weighted national average costs (2003-2004 euro).
  
  
  RESULTS
  ART infants were 4.4 times more likely to be low birthweight (LBW) compared with non-ART infants, translating into 89% higher birth-admission costs (euro2,832 and euro1,502, respectively). ART singletons were also more likely to be LBW compared with non-ART singletons, translating into 31% higher birth-admission costs (euro1,849 and euro1,415, respectively). After combining infant and maternal admission costs, the average cost of an ART singleton delivery was euro4,818 compared with euro13 890 for ART twins and euro54 294 for ART higher order multiples. Findings were not sensitive to changes in casemix.
  
  
  CONCLUSIONS
  The poorer neonatal outcomes of ART singletons compared with non-ART singletons are significant enough to impact healthcare resource consumption. The high costs associated with ART multiple births add to the overwhelming clinical and economic evidence in support of single embryo transfer.
authors: National Perinatal Statistics Unit, School of Women's and Children's Health, University of New South Wales, Randwick Hospitals Campus, Randwick, NSW 2031, Australia. g.chambers@unsw.edu.au
authors: Georgina M
authors: GM
authors: Chambers
authors: Michael G
authors: MG
authors: Chapman
authors: Narelle
authors: N
authors: Grayson
authors: Marian
authors: M
authors: Shanahan
authors: Elizabeth A
authors: EA
authors: Sullivan
mesh_terms: D000328:Adult; D001315:Australia; D005260:Female; D017721:Hospital Costs; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007297:Inpatients / Q000706:statistics & numerical data; D008297:Male; D009099:Multiple Birth Offspring / Q000706:statistics & numerical data*; D009774:Obstetrics / Q000191:economics* / Q000706:statistics & numerical data; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000191:economics*; D011272:Pregnancy, Multiple / Q000706:statistics & numerical data; D027724:Reproductive Techniques, Assisted / Q000191:economics* / Q000706:statistics & numerical data