Ischaemic complications of Glypressin in liver disease: a case series.
OBJECTIVE
To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin).


METHODS
We identified three patients who developed skin necrosis and determined any factors, which put them at an increased risk of doing so.


RESULTS
Two patients were obese and developed extensive abdominal wall skin necrosis. The third patient had lower limb chronic venous insufficiency and developed extensive necrosis of both lower limbs.


CONCLUSIONS
With increasing clinical use of terlipressin and an increasing incidence of obesity and non-alcoholic fatty liver disease-related cirrhosis, the incidence of these serious complications is likely to rise. Earlier recognition and treatment may lead to improved outcome.
Donnellan
Fergal
F
National Liver Transplant Unit, St Vincent's University Hospital, Dublin, Ireland.
Cullen
Garret
G
Hegarty
John E
JE
McCormick
P Aiden
PA
D005260:Female; D006801:Humans; D007511:Ischemia / Q000139:chemically induced*; D008103:Liver Cirrhosis / Q000150:complications* / Q000188:drug therapy; D008236:Lypressin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012867:Skin / Q000098:blood supply* / Q000473:pathology; D000077585:Terlipressin; D014662:Vasoconstrictor Agents / Q000009:adverse effects* / Q000627:therapeutic use
D014662:Vasoconstrictor Agents; D008236:Lypressin; D000077585:Terlipressin