[Progress in the study on mammalian diacylgycerol acyltransgerase (DGAT) gene and its biological function].
Diacylglycerol acyltransferase (DGAT; EC 2.3.1.20) is a microsomal enzyme that plays a central role in the metabolism of cellular glycerolipids. DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycero1. DGAT plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, and lactation. Therefore, DGAT is not only an key factor for control triglycerides and fatty acids, but also may play a key modulatory role in animal fat deposition.
Wang
Yan
Y
Animal Science and Technological College, Sichuan Agricultural University, Ya'an 625014, China. as519723614@163.com
Xu
Heng-Yong
HY
Zhu
Qing
Q
D000818:Animals; D002874:Chromosome Mapping; D051048:Diacylglycerol O-Acyltransferase / Q000235:genetics* / Q000378:metabolism*; D004075:Diglycerides / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000378:metabolism
C011439:1,2-diacylglycerol; D004075:Diglycerides; D014280:Triglycerides; D051048:Diacylglycerol O-Acyltransferase