Biflavones of Decussocarpus rospigliosii as phosphodiesterases inhibitors.
A phytochemical study of an ethyl acetate extract of Decussocarpus rospigliosii leaves led to the isolation of six 3'-8''-biapigenin derivatives identified as amentoflavone (1), podocarpusflavone A (2), sequoiaflavone (3), podocarpusflavone B (4), 7,7''-di-O-methylamentoflavone (5) and heveaflavone (6). Biflavones 1-4 showed strong inhibitory activity on several PDE isoforms. Biflavone (5) showed selective and potent inhibition of the PDE4 isoform (IC50=1.48+/-0.21 microM) and was almost as active as the reference drug Rolipram (IC50=1.1+/-0.2 microM).
Chaabi
Mehdi
M
LC1 UMR-CNRS 7175 Biotechnologies, Biomolécules et Innovations Thérapeutiques, Faculté de Pharmacie de Strasbourg, Illkirch, France.
Antheaume
Cyril
C
Weniger
Bernard
B
Justiniano
Hélène
H
Lugnier
Claire
C
Lobstein
Annelise
A
D000818:Animals; D044946:Biflavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D002417:Cattle; D006801:Humans; D010726:Phosphodiesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013379:Substrate Specificity; D064028:Tracheophyta / Q000737:chemistry*
D044946:Biflavonoids; D010726:Phosphodiesterase Inhibitors