Immunoreactivity of bovine schwannomas.
Thirty schwannomas from 22 cows were examined immunohistochemically. All were positive for vimentin and Ki-67 but negative for pancytokeratin, neurofilament, and desmin. S-100 immunolabelling varied between and within lesions. The numbers of tumours giving positive results for S-100, neuron-specific enolase (NSE) and glial fibrillary acidic protein (GFAP) were 16, 30 and 25, respectively. It was concluded that vimentin-positive tumours suspected to be schwannomas should also be immunolabelled for NSE and GFAP to confirm the diagnosis.
Nielsen
A B
AB
Department of Veterinary Pathobiology, Section of Pathology, Faculty of Life Sciences, University of Copenhagen, Ridebanevej 3, DK-1870 Frederiksberg C, Denmark.
Jansen
E C L
ECL
Department of Veterinary Pathobiology, Section of Pathology, Faculty of Life Sciences, University of Copenhagen, Ridebanevej 3, DK-1870 Frederiksberg C, Denmark.
Leifsson
P S
PS
Department of Veterinary Pathobiology, Section of Pathology, Faculty of Life Sciences, University of Copenhagen, Ridebanevej 3, DK-1870 Frederiksberg C, Denmark.
Jensen
H E
HE
Department of Veterinary Pathobiology, Section of Pathology, Faculty of Life Sciences, University of Copenhagen, Ridebanevej 3, DK-1870 Frederiksberg C, Denmark. Electronic address: helj@life.ku.dk.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D014408:Biomarkers, Tumor; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000473:pathology; D003937:Diagnosis, Differential; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000276:immunology; D019394:Ki-67 Antigen / Q000276:immunology; D009442:Neurilemmoma / Q000276:immunology* / Q000473:pathology / Q000662:veterinary*; D010524:Peripheral Nervous System Neoplasms / Q000276:immunology* / Q000473:pathology / Q000662:veterinary*; D009418:S100 Proteins / Q000276:immunology; D012583:Schwann Cells / Q000276:immunology / Q000473:pathology
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D007381:Intermediate Filament Proteins; D019394:Ki-67 Antigen; D009418:S100 Proteins