Postoperative hyperthermia, rhabdomyolysis, critical temperature, and death in a former premature infant after his ninth general anesthetic.
An 8-mo-old infant born at 24-wk of gestation died unexpectedly 12 h after his ninth uneventful general anesthetic. Preoperatively, he required low-flow nasal oxygen due to bronchopulmonary dysplasia, chronic diuretic therapy, and IV alimentation. As planned preoperatively, the infant remained tracheally intubated after his elective surgery and went to the Neonatal Intensive Care Unit in stable condition. However, over the next 6 h, he developed fever. The diagnosis of postoperative sepsis was considered. One hour before his death his temperature reached 43 degrees C. Autopsy documented Duchenne's muscular dystrophy and renal tubules containing myoglobin.
Phadke
Aparna
A
Department of Anesthesiology, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Broadman
Lynn M
LM
Brandom
Barbara W
BW
Ozolek
John
J
Davis
Peter J
PJ
D000701:Analgesics, Opioid; D000768:Anesthesia, General / Q000009:adverse effects*; D017809:Fatal Outcome; D005283:Fentanyl; D005334:Fever / Q000209:etiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008738:Methyl Ethers; D020388:Muscular Dystrophy, Duchenne / Q000473:pathology; D011183:Postoperative Complications / Q000209:etiology; D015742:Propofol; D012206:Rhabdomyolysis / Q000209:etiology*; D000077149:Sevoflurane
D000701:Analgesics, Opioid; D008738:Methyl Ethers; D000077149:Sevoflurane; D005283:Fentanyl; D015742:Propofol