title: A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea.
abstract: OBJECTIVE
  Methicillin-resistant Staphylococcus aureus (MRSA), originally restricted to hospitals, has emerged as a significant pathogen in the community. Although MRSA accounts for over 60% of S. aureus in tertiary hospitals in Korea, little is known about the epidemiology of community-associated MRSA (CA-MRSA).
  
  
  METHODS
  From January to July 2005, a hospital laboratory-based survey was conducted in seven community-based or tertiary hospitals. The medical records and Health Insurance Review Agency databases were reviewed and MRSA isolated from patients without apparent risk factors was defined as CA-MRSA. Susceptibilities to 12 antibiotics were tested by the disc diffusion method. SCCmec typing, Panton-Valentine leucocidin (PVL) gene detection and multilocus sequence typing (MLST) were performed according to published protocols.
  
  
  RESULTS
  Of 3,251 S. aureus, 1,900 (58.4%) were MRSA. CA-MRSA accounted for 112 (5.9%) of the MRSA. Of the 112 CA-MRSA isolates, 27 and 33 were found to be pathogens and colonizers, respectively. Fifty-two isolates from the patients with chronic otitis media were classified as 'undetermined'. Most of the 27 CA-MRSA patients had skin and soft tissue infections or acute ear infections. None of the patients died during the study period. Among 72 isolates tested, 64% were multidrug-resistant. SCCmec type IVa was the most common type among the colonizers and pathogens. On MLST analysis, ST72 was predominant, but ST5 and ST239 were prevalent in the 'undetermined' group. None possessed the PVL gene.
  
  
  CONCLUSIONS
  Despite MRSA-endemic hospital settings, CA-MRSA infections are not common in Korea. A new clone of CA-MRSA, ST72-SCCmec type IVa without the PVL gene, is the most common form.
authors: Department of Internal Medicine, Dongguk University College of Medicine, Goyang, Republic of Korea.
authors: Eu Suk
authors: ES
authors: Kim
authors: Jin Su
authors: JS
authors: Song
authors: Hye Jin
authors: HJ
authors: Lee
authors: Pyoeng Gyun
authors: PG
authors: Choe
authors: Kyung Hwa
authors: KH
authors: Park
authors: Jae Hyun
authors: JH
authors: Cho
authors: Wan Beom
authors: WB
authors: Park
authors: Sung-Han
authors: SH
authors: Kim
authors: Ji-Hwan
authors: JH
authors: Bang
authors: Dong-Min
authors: DM
authors: Kim
authors: Kyoung Un
authors: KU
authors: Park
authors: Sue
authors: S
authors: Shin
authors: Mi Suk
authors: MS
authors: Lee
authors: Hee Jung
authors: HJ
authors: Choi
authors: Nam Joong
authors: NJ
authors: Kim
authors: Eui-Chong
authors: EC
authors: Kim
authors: Myoung-Don
authors: MD
authors: Oh
authors: Hong Bin
authors: HB
authors: Kim
authors: Kang Won
authors: KW
authors: Choe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000382:microbiology*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007723:Korea / Q000453:epidemiology; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects*