title: MR microscopy of the lung in small rodents.
abstract: Understanding how the mammalian respiratory system works and how it changes in disease states and under the influence of drugs is frequently pursued in model systems such as small rodents. These have many advantages, including being easily obtained in large numbers as purebred strains. Studies in small rodents are valuable for proof of concept studies and for increasing our knowledge about disease mechanisms. Since the recent developments in the generation of genetically designed animal models of disease, one needs the ability to assess morphology and function in in vivo systems. In this article, we first review previous reports regarding thoracic imaging. We then discuss approaches to take in making use of small rodents to increase MR microscopic sensitivity for these studies and to establish MR methods for clinically relevant lung imaging.
authors: Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. mtakahas@bidmc.harvard.edu
authors: Masaya
authors: M
authors: Takahashi
authors: Shigeto
authors: S
authors: Kubo
authors: Shigeru
authors: S
authors: Kiryu
authors: James
authors: J
authors: Gee
authors: Hiroto
authors: H
authors: Hatabu
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology; D008171:Lung Diseases / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D023421:Models, Animal; D012143:Respiratory Physiological Phenomena; D012377:Rodentia