title: Synthesis of the antimalarial drug FR900098 utilizing the nitroso-ene reaction.
abstract: The antimalarial drug FR900098 was prepared from diethyl allylphosphonate involving the nitroso-ene reaction with nitrosocarbonyl methane as the key step followed by hydrogenation and dealkylation. The utilization of dibenzyl allylphosphonate as the starting compound allows one-step hydrogenation with dealkylation, which simplifies the preparative scheme further.
authors: Department of Organic Chemistry, Kiev Polytechnic Institute, pr. Pobedy 37, 03056 Kiev, Ukraine. aaf@xtf.ntu-kpi.kiev.ua
authors: Andrey A
authors: AA
authors: Fokin
authors: Alexander G
authors: AG
authors: Yurchenko
authors: Vladimir N
authors: VN
authors: Rodionov
authors: Pavel A
authors: PA
authors: Gunchenko
authors: Raisa I
authors: RI
authors: Yurchenko
authors: Armin
authors: A
authors: Reichenberg
authors: Jochen
authors: J
authors: Wiesner
authors: Martin
authors: M
authors: Hintz
authors: Hassan
authors: H
authors: Jomaa
authors: Peter R
authors: PR
authors: Schreiner
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005578:Fosfomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006865:Hydrogenation; D015394:Molecular Structure; D009603:Nitroso Compounds / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D009603:Nitroso Compounds; D063065:Organophosphonates; D005578:Fosfomycin; C024639:3-(N-acetyl-N-hydroxy)aminopropylphosphonic acid