Adverse reactions to chlorpromazine in psychiatric patients.
In 470 consecutively monitored psychiatric inpatients who received chlorpromazine, adverse reactions attributed to the drug were reported in 150 (31.9%); and in three, the reaction was considered life-threatening (0.6%). Reactions were more frequent with higher daily doses and the intramuscular route was associated with earlier onset of a reaction.
Swett
C
C
Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Waltham, Massachusetts 02154, USA.
D000284:Administration, Oral; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced; D002318:Cardiovascular Diseases / Q000139:chemically induced; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D016638:Critical Illness; D004305:Dose-Response Relationship, Drug; D004700:Endocrine System Diseases / Q000139:chemically induced; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D001523:Mental Disorders / Q000188:drug therapy*; D009422:Nervous System Diseases / Q000139:chemically induced; D013997:Time Factors
D014150:Antipsychotic Agents; D002746:Chlorpromazine