Hypertension in connexin40-null mice: a renin disorder.
Studies described in this issue indicate that the gap junction protein connexin40 (Cx40) appears to play an unexpected role in blood pressure regulation. In mice lacking this gap junction protein, renin secretion is high and not regulated by arteriolar pressure.
Spray
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Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA. spray@aecom.yu.edu
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D017630:Connexins / Q000235:genetics / Q000378:metabolism*; D017629:Gap Junctions / Q000502:physiology*; D006973:Hypertension / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D012083:Renin / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism; D000097003:Gap Junction alpha-5 Protein
D017630:Connexins; D012083:Renin; D000097003:Gap Junction alpha-5 Protein