title: Idiopathic granulomatous mastitis: in search of a therapeutic paradigm.
abstract: Idiopathic granulomatous mastitis, also known as idiopathic granulomatous lobular mastitis, is a benign breast lesion that represents both a diagnostic and therapeutic dilemma. We report two cases of granulomatous mastitis recently evaluated and managed at our institution. To better understand this rare disease, we analyzed treatment outcomes in reported cases of granulomatous mastitis. One hundred sixteen cases were subsequently analyzed. Primary management strategies included observation (n = 9), steroids (n = 29), partial mastectomy (n = 75), and mastectomy (n = 3). Success rates with each treatment were observation, 56 per cent; steroids, 42 per cent; partial mastectomy, 79 per cent; and mastectomy, 100 per cent. Based on this analysis, we propose a clinically useful algorithm for both workup and management of these challenging cases.
authors: Department of Surgery, Division of Surgical Oncology, University of Florida, Gainesville, Florida, USA.
authors: Jason P
authors: JP
authors: Wilson
authors: Nicole
authors: N
authors: Massoll
authors: Julia
authors: J
authors: Marshall
authors: Robin M
authors: RM
authors: Foss
authors: Edward M
authors: EM
authors: Copeland
authors: Stephen R
authors: SR
authors: Grobmyer
mesh_terms: D000328:Adult; D001706:Biopsy; D002585:Cesarean Section; D003657:Decision Making; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use*; D006099:Granuloma / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008408:Mastectomy; D008413:Mastitis / Q000175:diagnosis / Q000628:therapy*; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications; D014057:Tomography, X-Ray Computed; D016217:Ultrasonography, Mammary
chemical_list: D005938:Glucocorticoids; D011241:Prednisone