Resolution of an oral ulcer secondary to acetaminophen/hydrocodone withdrawal.
Acetaminophen/hydrocodone is a common non-opioid/opioid analgesic indicated for the treatment of moderate to severe pain. The following report depicts a unique case involving a 57-year-old woman with a persistent, painful oral ulcer that was unresponsive to standard treatments. The ulcer was resolved when the patient discontinued acetaminophen/hydrocodone use. The cause of the ulcer is unclear but it was speculated to result from a systemic hypersensitivity reaction to acetaminophen/hydrocodone.
Balasubramaniam
Ramesh
R
Orofacial Pain Center, College of Dentistry and Medicine, University of Kentucky, Lexington, USA.
Lin
Po-Ching
PC
White
Dean K
DK
Yepes
Juan F
JF
D000082:Acetaminophen / Q000009:adverse effects*; D000701:Analgesics, Opioid / Q000009:adverse effects*; D004338:Drug Combinations; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D006853:Hydrocodone / Q000009:adverse effects*; D017116:Low Back Pain / Q000188:drug therapy; D008875:Middle Aged; D019226:Oral Ulcer / Q000139:chemically induced*
D000701:Analgesics, Opioid; D004338:Drug Combinations; C083640:acetaminophen, hydrocodone drug combination; D000082:Acetaminophen; D006853:Hydrocodone