title: The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia.
abstract: The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.
authors: Cattedra di Ematologia, Centro Trapianti Midollo osseo, Ospedale R. Binaghi, Dipartimento di Scienze Mediche Internistiche, University of Cagliari, Cagliari, Italy.
authors: Giorgio
authors: G
authors: La Nasa
authors: Roberto
authors: R
authors: Littera
authors: Franco
authors: F
authors: Locatelli
authors: Sara
authors: S
authors: Lai
authors: Francesco
authors: F
authors: Alba
authors: Giovanni
authors: G
authors: Caocci
authors: Daniela
authors: D
authors: Lisini
authors: Sonia
authors: S
authors: Nesci
authors: Adriana
authors: A
authors: Vacca
authors: Eugenia
authors: E
authors: Piras
authors: Maria Ester
authors: ME
authors: Bernardo
authors: Alessandra
authors: A
authors: Di Cesare-Merlone
authors: Sandro
authors: S
authors: Orrù
authors: Carlo
authors: C
authors: Carcassi
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D017353:Gene Deletion; D005805:Genes, MHC Class I; D005820:Genetic Testing; D006086:Graft vs Host Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D018570:Risk Assessment / Q000379:methods; D013789:Thalassemia / Q000276:immunology / Q000601:surgery*; D016896:Treatment Outcome