title: T-cell therapy after hematopoietic stem cell transplantation.
abstract: OBJECTIVE
  The separation of graft versus host disease from graft versus leukaemia reactivity and the reconstitution of immunity to infectious agents are the main goals of T-cell therapy after allogeneic hematopoietic stem cell transplantation. We describe how an improved understanding of T-cell mediated graft versus leukemia and of antiviral responses is providing effective approaches to T-cell immunotherapy.
  
  
  RESULTS
  Over the past several years, researchers have developed strategies to eliminate alloreactive T cells from the graft, to expand naturally occurring regulatory T cells, and to select and expand antigen-specific T cells specific for tumor-associated or viral antigens. Incorporation of suicide genes allows the selective destruction of allodepleted or antigen-selected cells after infusion, further increasing the safety and potential applicability of these approaches.
  
  
  CONCLUSIONS
  In this review we describe current strategies for adoptive T-cell immunotherapy after hematopoietic stem cell transplantation.
authors: Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA. aakenned@txccc.org
authors: Alana A
authors: AA
authors: Kennedy-Nasser
authors: Malcolm K
authors: MK
authors: Brenner
mesh_terms: D000946:Antigens, Fungal / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D006086:Graft vs Host Disease / Q000517:prevention & control; D020544:Graft vs Leukemia Effect; D019337:Hematologic Neoplasms / Q000276:immunology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D016219:Immunotherapy, Adoptive; D007694:Killer Cells, Natural / Q000276:immunology; D008212:Lymphocyte Depletion / Q000379:methods; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*
chemical_list: D000946:Antigens, Fungal; D000951:Antigens, Neoplasm; D000956:Antigens, Viral