Incorporation and washout of n-3 polyunsaturated fatty acids after diet supplementation in clinical studies.
Current evidence suggests that at least part of the cardioprotective benefits of consumption of long-chain n-3 polyunsaturated fatty acids (PUFAs) relates to their incorporation into the phospholipids of cardiac cell membranes. Dietary supplementation with purified extracts of n-3 PUFAs derived from fish oil rapidly alters the composition of fatty acids in blood cell membranes and in other tissues. The present review summarises the time-course and dose-dependent incorporation and washout of n-3 PUFAs in the clinical setting and discusses the implications of these pharmacokinetic data in terms of biological effects.
Masson
Serge
S
Department of Medicine, New York Medical College, Valhalla, NY10595, USA.
Latini
Roberto
R
Tacconi
Mariateresa
M
Bernasconi
Roberto
R
D001773:Blood Cells / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D010743:Phospholipids / Q000378:metabolism
D015525:Fatty Acids, Omega-3; D010743:Phospholipids