title: Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population.
abstract: Atendency to extract spurious, message-like meaning from meaningless noise was assessed as a risk factor leading to schizophrenia-spectrum disorders by assessing word length of speech illusions elicited by multispeaker babble in 43 people with prodromal symptoms. These individuals were randomised to olanzapine v. placebo groups during year 1 followed by no pharmacological treatment for those with no disorder conversion during year 2. A time-dependent Cox regression analysis of conversion to schizophrenia-spectrum disorder revealed a significant interaction between condition (olanzapine v. no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment.
authors: Yale-New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA. ralph.hoffman@yale.edu
authors: Ralph E
authors: RE
authors: Hoffman
authors: Scott W
authors: SW
authors: Woods
authors: Keith A
authors: KA
authors: Hawkins
authors: Brian
authors: B
authors: Pittman
authors: Mauricio
authors: M
authors: Tohen
authors: Adrian
authors: A
authors: Preda
authors: Alan
authors: A
authors: Breier
authors: Jill
authors: J
authors: Glist
authors: Jean
authors: J
authors: Addington
authors: Diana O
authors: DO
authors: Perkins
authors: Thomas H
authors: TH
authors: McGlashan
mesh_terms: D003702:Delusions / Q000523:psychology*; D018450:Disease Progression; D006801:Humans; D009483:Neuropsychological Tests / Q000592:standards; D009622:Noise; D011237:Predictive Value of Tests; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D013067:Speech Perception