Platelet-rich plasma may not provide any additional effect when associated with guided bone regeneration around dental implants in dogs.
OBJECTIVE
The aim of this study was to evaluate histometrically bone healing in surgically created dehiscence-type defects around titanium implants treated with an association of platelet-rich plasma (PRP) and guided bone regeneration (GBR).


METHODS
Ten male adult mongrel dogs were used, from which the three low premolars (P2, P3, P4) and the first molar were extracted. Three months after teeth extraction, two implant sites were bilaterally drilled, buccal bone dehiscences were created and four titanium implants were placed. Dehiscences were randomly assigned to the following groups: (1) PRP, (2) GBR, (3) PRP+GBR and (4) control. After 3 months, the animals were sacrificed and the implants and adjacent hard tissues were processed for undecalcified sections. Bone-to-implant contact (BIC), bone density within the limits of implant threads (BW), bone density (BD) and new bone area (BA) in a zone lateral to the implant corresponding to bone defects were obtained and measured.


RESULTS
Intergroup analysis (two-way ANOVA -alpha=5%) demonstrated that when PRP was utilized,no differences were observed for all parameters (P>0.05). However, significant differences were observed for BIC and BW toward membrane-treated groups (P<0.05).


CONCLUSIONS
Within the limits of this study, it was concluded that PRP does not exert additional effects on bone healing in bone defects created around dental implants and treated by GBR.
de Vasconcelos Gurgel
Bruno César
BC
Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Piracicaba/Unicamp, São Paulo, Brazil.
Gonçalves
Patrícia Furtado
PF
Pimentel
Suzana Peres
SP
Ambrosano
Gláucia Maria Bovi
GM
Nociti Júnior
Francisco Humberto
FH
Sallum
Enilson Antonio
EA
Casati
Marcio Zaffalon
MZ
D000818:Animals; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology*; D015921:Dental Implants; D003764:Dental Materials; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal; D008297:Male; D008334:Mandible / Q000601:surgery; D008336:Mandibular Diseases / Q000601:surgery; D008567:Membranes, Artificial; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D053657:Platelet-Rich Plasma / Q000502:physiology*; D011138:Polytetrafluoroethylene; D011897:Random Allocation; D013529:Surgical Wound Dehiscence / Q000601:surgery; D013997:Time Factors; D014025:Titanium
D015921:Dental Implants; D003764:Dental Materials; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene; D014025:Titanium