Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study.
OBJECTIVE
Angiotensin converting enzyme (ACE) plays major roles in the pathogenesis of cardiovascular diseases (CVD). However, findings on the relations between ACE variants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci (QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases (estimated heritability = 0.58).


METHODS
With 1,271 individuals from 373 young-onset (age <or=40) hypertension pedigrees, 479 deCODE microsatellite markers were genotyped.


RESULTS
We identified a previously unknown loci on chromosomes 9 at 149.4 cM (LOD = 3.00) in addition to a strong linkage peak near the ACE structural locus on chromosome 17 at 89.6 cM (LOD = 4.60).


CONCLUSIONS
These results not only indicate that the ACE gene or nearby loci on 17q was among the strongest QTL influencing ACE activity, but also reveal a potential ACE QTL in human genome, pointing to the complexity of ACE regulation.
Wang
Ruey-Yun
RY
Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan, ROC.
Chung
Chia-Min
CM
Fann
Cathy S J
CS
Yang
Hsin-Chou
HC
Chen
Jaw-Wen
JW
Jong
Yuh-Shiun
YS
Jou
Yuh-Shan
YS
Lo
Huey-Ming
HM
Ho
Feng-Ming
FM
Kang
Chih-Sen
CS
Chen
Chien-Chung
CC
Chang
Huan-Cheng
HC
Shyue
Song-Kun
SK
Pan
Wen-Harn
WH
D017668:Age of Onset; D002318:Cardiovascular Diseases / Q000201:enzymology; D005260:Female; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D013624:Taiwan
D007703:Peptidyl-Dipeptidase A