Electroencephalographic activation with methohexital in an epileptic population.
Forty-one epileptics with normal or nonspecific EEG changes were subjected to methohexital and pentylenetetrazol activations (Group I). Fifteen epileptic patients with specific epileptiform discharges were subjected to methohexital activation procedures (Group II). The present study showed that, though it is a safe agent, methohexital is not an effective electroencephalographic activator for the epileptic population. In this study, it activated only 7% of the epileptics with normal records or minimal and nonspecific EEG abnormalities and it activated only 33.3% of epileptics who had previously demonstrated a specific paroxysmal epileptiform discharge in a routine recording.
Aung
M H
MH
Department of Neurosciences, University of California, San Diego, USA.
D000293:Adolescent; D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D003292:Convulsants / Q000008:administration & dosage / Q000494:pharmacology; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008723:Methohexital / Q000494:pharmacology*; D008875:Middle Aged; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000494:pharmacology
D018686:Anesthetics, Intravenous; D003292:Convulsants; D008723:Methohexital; D010433:Pentylenetetrazole