Sustained immunologic and virologic efficacy after four years of highly active antiretroviral therapy in human immunodeficiency virus infected children in Thailand.
We report the long-term efficacy of highly active antiretroviral therapy (HAART) in 107 antiretroviral-naive human immunodeficiency virus (HIV)-infected Thai children. In an intention-to-treat analysis, 70% of the children had undetectable HIV RNA titers after 192 weeks of HAART. The mean CD4 cell percentage increased from 5.3% to 26.6%. HAART is effective for HIV-infected children in this resource-poor setting despite initiation of treatment in the advanced stage of disease.
Puthanakit
Thanyawee
T
Research Institute for Health Sciences, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Aurpibul
Linda
L
Oberdorfer
Peninnah
P
Akarathum
Noppadon
N
Kanjanavanit
Suparat
S
Wannarit
Pornphun
P
Sirisanthana
Thira
T
Sirisanthana
Virat
V
D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D013785:Thailand; D016896:Treatment Outcome
D012367:RNA, Viral