Clozapine-related agranulocytosis associated with fever of unknown origin, protective hospitalisation, and multiple adverse events related to the administration of empiric antimicrobial treatment.
An exemplary case report of a patient who developed an unpredictable sudden, late-onset clozapine-related life-threatening agranulocytosis expressed by a nadir of 14 polymorphonuclear cells/microL, and subsequently underwent protective hospitalisation and broad spectrum, empiric antimicrobial therapy and also experienced serious intolerance to a number of administered antibiotic and antifungal agents, is reported and discussed on the grounds of the available evidence from the literature.
Manfredi
Roberto
R
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy. Roberto.manfredi@unibo.it
Sabbatani
Sergio
S
D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000150:complications; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D005335:Fever of Unknown Origin / Q000139:chemically induced* / Q000150:complications; D006760:Hospitalization; D006801:Humans; D007958:Leukocyte Count; D008297:Male
D000890:Anti-Infective Agents; D014150:Antipsychotic Agents; D003024:Clozapine