title: Gastrointestinal complications in renal transplant recipients: MITOS study.
abstract: METHODS
  An epidemiologic multicenter study was performed to evaluate the prevalence and management of gastrointestinal (GI) complications in solid organ transplant patients. A total of 1788 recipients were included, 1132 of which corresponded to renal transplanted patients.
  
  
  RESULTS
  The mean age for the renal transplanted patients was 52 +/- 13.2 years. The mean time from the transplantation was 5.4 +/- 5.4 years. 17.7% showed some pretransplant GI disease, while 53% presented this type of complication in the posttransplant period. Diarrhea was the most prevalent GI complication (51.5%) and digestive perforation was the GI disorder that affected the patients daily living the most. From the patients with GI complications, 71% received pharmacological treatment, using gastric protectors in 91.3% of the cases. Regarding immunosuppressive drugs, in 30.9% of the cases the dose of the drug was reduced, in 9.3% discontinued temporarily and in 7.5% discontinued permanently. These changes mainly affected the MMF (89%, 83% and 74% for dose change, temporary and permanent discontinuation, respectively).
  
  
  CONCLUSIONS
  The prevalence of GI complications in renal transplant exceeded 50%, and affected patients' daily living. The management of these complications was based on treatment with gastric protectors, dose reduction and/or partial or definitive MMF discontinuation.
authors: H. Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. sgilvernet@csub.scs.es
authors: S
authors: S
authors: Gil-Vernet
authors: A
authors: A
authors: Amado
authors: F
authors: F
authors: Ortega
authors: A
authors: A
authors: Alarcón
authors: G
authors: G
authors: Bernal
authors: L
authors: L
authors: Capdevila
authors: J F
authors: JF
authors: Crespo
authors: J M
authors: JM
authors: Cruzado
authors: E
authors: E
authors: De Bonis
authors: N
authors: N
authors: Esforzado
authors: A M
authors: AM
authors: Fernandez
authors: A
authors: A
authors: Franco
authors: L
authors: L
authors: Hortal
authors: C
authors: C
authors: Jiménez
mesh_terms: D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000453:epidemiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013030:Spain / Q000453:epidemiology
chemical_list: D007166:Immunosuppressive Agents