Moving chromatin within the interphase nucleus-controlled transitions?
The past decade has seen an increasing appreciation for nuclear compartmentalization as an underlying determinant of interphase chromosome nuclear organization. To date, attention has focused primarily on describing differential localization of particular genes or chromosome regions as a function of differentiation, cell cycle position, and/or transcriptional activity. The question of how exactly interphase chromosome compartmentalization is established and in particular how interphase chromosomes might move during changes in nuclear compartmentalization has received less attention. Here we review what is known concerning chromatin mobility in relationship to physiologically regulated changes in nuclear interphase chromosome organization.
Chuang
Chien-Hui
CH
Department of Cell and Developmental Biology, University of Illinois, Urbana-Champaign, B107 CLSL, 601 S. Goodwin Avenue, Urbana, IL 61801, USA.
Belmont
Andrew S
AS
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology*; D002843:Chromatin / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002875:Chromosomes / Q000502:physiology; D006801:Humans; D007399:Interphase / Q000502:physiology*
D002843:Chromatin