title: Effects of angiotensin II and captopril on rewarding properties of morphine.
abstract: The effects of captopril and Ang II on morphine-induced conditioned place preference (CPP) and morphine self-administration in male Wistar rat were investigated. In CPP experiment, injection of captopril before test significantly decreased the difference of the time spent in compartment A between pre- and post-conditioning compared to morphine group. In self- administration experiment number of active lever pressing was significantly greater than passive in morphine group. In captopril group number of active lever pressing was significantly lower than morphine group however, there was not significant difference between active and passive lever pressed number. The results showed that captopril significantly decreased morphine-induced conditional place preference and morphine self-administration but the effect of Ang II was not significant. It can be concluded that RAS may have a role in rewarding properties of morphine.
authors: Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. smhosseini49@hotmail.com
authors: Mahmoud
authors: M
authors: Hosseini
authors: Mohammad Reza
authors: MR
authors: Sharifi
authors: Hojatallah
authors: H
authors: Alaei
authors: Mohammad Naser
authors: MN
authors: Shafei
authors: Habib Allah Nemati
authors: HA
authors: Karimooy
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D003213:Conditioning, Psychological; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D012201:Reward; D012646:Self Administration
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D009020:Morphine; D002216:Captopril