Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors.
A facile, one-pot synthesis of thio and selenourea derivatives from amines using tetrathiomolybdate 1 and tetraselenotungstate 2 as sulfur and selenium transfer reagents, respectively, is reported. The compounds were tested for their activity as urease inhibitors and some of the compounds showed potent activity in the nanomolar range towards jack bean urease.
Sivapriya
Kirubakaran
K
Department of Organic Chemistry, Indian Institute of Science, Bangalore, India.
Suguna
Perumal
P
Banerjee
Arun
A
Saravanan
Vadivelu
V
Rao
Desirazu N
DN
Chandrasekaran
Srinivasan
S
D032449:Canavalia / Q000201:enzymology; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013890:Thiourea / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014510:Urease / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D016566:Organoselenium Compounds; C081959:selenourea; D008982:Molybdenum; D014508:Urea; C020809:tetrathiomolybdate; D014510:Urease; D013890:Thiourea