title: Induction of apoptosis by diterpenes from the soft coral Xenia elongata.
abstract: Four new diterpenes ( 1- 4) were isolated from the soft coral Xenia elongata using a novel cell-based screen for apoptosis-inducing, potential anticancer compounds. The molecular structures of the diterpenes were determined using a combination of NMR and mass spectrometry. The bioactivities were confirmed using a specific apoptosis induction assay based on genetically engineered mammalian lines with differential, defined capacities for apoptosis. The diterpenes induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by marine diterpenes in xenicane skeletons.
authors: Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08901-8521, USA.
authors: Eric H
authors: EH
authors: Andrianasolo
authors: Liti
authors: L
authors: Haramaty
authors: Kurt
authors: K
authors: Degenhardt
authors: Robin
authors: R
authors: Mathew
authors: Eileen
authors: E
authors: White
authors: Richard
authors: R
authors: Lutz
authors: Paul
authors: P
authors: Falkowski
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes