Maculas, monkeys, models, AMD and aging.
Age related macular degeneration (AMD) signs may be found reliably in monkeys (Macaca mulatta) bred selectively in Florida after 14 generations of inbreeding in a closed colony at the University of Puerto Rico. Progression, ultrastructure and functional losses are parallel to those found in humans.
Dawson
William W
WW
Department of Ophthalmology, University of Florida, 1600 SW Archer Road, Rm: M119, Gainesville, FL 32610-0284, USA. wdawson@eye.ufl.edu
Dawson
Judyth C
JC
Lake
Kenneth P
KP
Gonzalez-Martinez
Janis
J
D000375:Aging / Q000473:pathology* / Q000502:physiology; D000818:Animals; D016570:Bruch Membrane / Q000648:ultrastructure; D004195:Disease Models, Animal; D018450:Disease Progression; D000882:Haplorhini; D008253:Macaca mulatta; D008268:Macular Degeneration / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D010375:Pedigree; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure; D015593:Retinal Drusen / Q000235:genetics / Q000473:pathology