Interaction between CD14 and LXRbeta genes modulates Alzheimer's disease risk.
A chronic inflammatory process with activation of microglial cells contribute to the neurodegeneration associated with Alzheimer's disease (AD). CD14 and LXRbeta are receptors involved in the regulation of inflammatory responses of microglia in response to bacterial infection or lipopolysaccharide stimulation. In a case-control study in 266 AD patients and 273 healthy controls, we examined whether the combined gene effects between CD14 (-260) polymorphism and LXRbeta (intron 5) polymorphism might be responsible for susceptibility to AD. Subjects carrying both the CD14 (-260) C/C and the LXRbeta (intron 5) G/G genotypes had a six times lower risk of developing AD than subjects without these risk genotypes (OR 0.16, 95% CI 0.04-0.67, p=0.01). These data support a role for innate immune response genes in risk for AD.
Rodríguez-Rodríguez
Eloy
E
Neurology Service, University Hospital Marqués de Valdecilla (University of Cantabria), Santander, Spain.
Sánchez-Juan
Pascual
P
Mateo
Ignacio
I
Infante
Jon
J
Sánchez-Quintana
Coro
C
García-Gorostiaga
Inés
I
Berciano
José
J
Combarros
Onofre
O
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D001921:Brain / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000276:immunology; D004660:Encephalitis / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D005819:Genetic Markers / Q000235:genetics / Q000276:immunology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D005911:Gliosis / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007438:Introns / Q000235:genetics; D018950:Lipopolysaccharide Receptors / Q000235:genetics* / Q000276:immunology; D000071518:Liver X Receptors; D008297:Male; D017628:Microglia / Q000276:immunology / Q000378:metabolism; D008875:Middle Aged; D015166:Monitoring, Immunologic; D057093:Orphan Nuclear Receptors; D011110:Polymorphism, Genetic / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics* / Q000276:immunology
D004268:DNA-Binding Proteins; D005819:Genetic Markers; D018950:Lipopolysaccharide Receptors; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear