title: Which genotype of MAO gene that the patients have are likely to be most susceptible to the symptoms of fibromyalgia?
abstract: The objective of this study was to analyze the genotype distributions and allele frequencies for the MAO-A and MAO-B polymorphism of the MAO gene among the patients with fibromyalgia syndrome (FS). One hundred and seven fibromyalgia patients and 90 unrelated healthy subjects were included into the study. Genomic DNA of 107 FS patients and 90 healthy control subjects were analyzed by polymerase chain reaction. Polymorphism of the MAO gene was: 1-1, 1-3, 3-3, 3-4. The "allele 3" had a 2.7 to 4.8-fold increased transcription activity than the "allele 1". The frequencies of the genotypes of the patients with FS and healthy controls were compared. Although no significant difference was found in genotypes of patients and controls (P = 0.0559), it is likely that "allele 3" could be a more riskful factor for FS than "allele 1" (P = 0.033). Fibromyalgia impact questionnaire was administered to FS group as well as control group. One of our findings is that, the patients whose genotype 3-3 may be mostly affected by the symptoms of FS. In conclusion, it seems plausible to say that MAOA-dependent metabolism of the biological amines may be partly related to high-activated MAO-A, allele 3, in the occurrence of FS among Turkish population.
authors: School of Medicine, Department of Physical Medicine and Rehabilitation, Gaziantep University, Gaziantep, 27010, Turkey. gursoy@gantep.edu.tr
authors: Savaş
authors: S
authors: Gürsoy
authors: Emin
authors: E
authors: Erdal
authors: Melek
authors: M
authors: Sezgin
authors: Ibrahim Omer
authors: IO
authors: Barlas
authors: Ali
authors: A
authors: Aydeniz
authors: Belgin
authors: B
authors: Alaşehirli
authors: Günşah
authors: G
authors: Sahin
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005356:Fibromyalgia / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013577:Syndrome; D014421:Turkey / Q000453:epidemiology
chemical_list: D008995:Monoamine Oxidase