Haplotype analysis confirms association of the serotonin transporter (5-HTT) gene with schizophrenia but not with major depression.
Serotonin (5-HT) has been implicated in the pathophysiology of several psychiatric disorders including major depressive disorder (MDD) and schizophrenia (SCZ). The serotonin transporter (5-HTT) is a major regulator of 5-HT function. 5-HTT gene polymorphic variants have been associated with both MDD and SCZ. A case-control design was used for candidate gene-disease association in 194 MDD patients, 155 schizophrenic psychosis patients, and 246 healthy controls, all North European Caucasians. Four polymorphisms were analyzed in terms of genotype, allele, and haplotype-based associations. Linkage disequilibrium (LD) analysis was also carried out. Bonferroni correction was used for multiple testing. Haplotype-based analyses showed significant associations between 5-HTT and SCZ but not MDD. No single locus associations were observed. In agreement with published meta-analysis our results indicate that 5-HTT associates with SCZ but not with MDD. It appears that risk for SCZ maps within a specific 5-HTT haplotype block.
Zaboli
Ghazal
G
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute and Hospital, Stockholm, Sweden.
Jönsson
Erik G
EG
Gizatullin
Rinat
R
De Franciscis
Alessandra
A
Asberg
Marie
M
Leopardi
Rosario
R
D000328:Adult; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
D017931:DNA Primers; D050486:Serotonin Plasma Membrane Transport Proteins