title: Bacterial biofilms may explain chronicity in osteoradionecrosis of the temporal bone.
abstract: OBJECTIVE
  To identify biofilm formation within a case of temporal bone osteoradionecrosis.
  
  
  METHODS
  Single-case patient presenting with temporal bone osteoradionecrosis.
  
  
  METHODS
  Antibiotic therapy and then surgical debridement of the temporal bone.
  
  
  METHODS
  Histologic identification of biofilm formation within the affected temporal bone specimen.
  
  
  RESULTS
  Positive identification of biofilm formation in multiple sections of the temporal bone specimen removed from a patient affected by osteoradionecrosis.
  
  
  CONCLUSIONS
  This is the first evidence that temporal bone osteoradionecrosis involves biofilm formation. Such a pathogenic mechanism may explain the recalcitrance of this disease process and offer new strategies in formulating therapeutic interventions.
authors: Department of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors: Robert
authors: R
authors: Nason
authors: Richard A
authors: RA
authors: Chole
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D018441:Biofilms; D002908:Chronic Disease; D003646:Debridement; D034381:Hearing Loss / Q000209:etiology; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D010025:Osteoradionecrosis / Q000150:complications / Q000382:microbiology* / Q000601:surgery; D013701:Temporal Bone / Q000382:microbiology*; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents