[Affinoleukin in combined treatment of psoriasis].
Open randomized controlled clinical trials in which 161 patients were included showed that Affinoleukin (commercial drug which contains low molecular weight proteins obtained from extract of human leukocytes membranes) was effective in treatment of psoriasis. Affinoleukin, when added to regular treatment, accelerated the establishment of remission and its duration by restoration of impaired regulatory and defensive functions of T-lymphocytes, particularly, gamma deltaT- and NKT-cells as well as monocytes and NK-cells. Regular treatment led to marked positive effect in 45% of patients with severe psoriasis and psoriasis of intermediate severity. Addition of Affinoleukin in combined treatment increased proportion of patients with marked positive effect to 72%. Magnitude of Affinoleukin effect was directly related with its dose and severity of psoriasis. Course of Affinoleukin injections (up to 30 units in adults) is worthwhile to use as immunobiological component of combined treatment of exacerbations of severe psoriasis and psoriasis of intermediate severity.
Mats
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Znamenskaia
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Fattiakhetdinova
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Iashin
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Denisova
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Trofimova
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001688:Biological Products / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D002452:Cell Count; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007279:Injections, Subcutaneous; D007694:Killer Cells, Natural / Q000276:immunology; D007962:Leukocytes / Q000737:chemistry; D008297:Male; D008565:Membrane Proteins / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D008875:Middle Aged; D008970:Molecular Weight; D009000:Monocytes / Q000166:cytology; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy*; D016692:Receptors, Antigen, T-Cell, gamma-delta; D016176:T-Lymphocyte Subsets / Q000276:immunology; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D001688:Biological Products; D007166:Immunosuppressive Agents; D008565:Membrane Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta