Synthesis and insecticidal evaluation of novel N'-tert-butyl-N'-substitutedbenzoyl-N-5-chloro-6-chromanecarbohydrazide derivatives.
A series of novel N'-tert-butyl- N'-substitutedbenzoyl-N-5-chloro-6-chromanecarbohydrazide derivatives were synthesized, and their larvicidal activities against Oriental armyworm were evaluated. The results of bioassays indicated that most of these title compounds exhibit higher larvicidal activities than RH-5849, and several of them somewhat lower than the commercial insecticide tebufenozide. The larvicidal activities are strongly associated with the types and patterns of substitution on the benzene, and 3,5-dimethyl, 2-nitro-4-chloro and 3-methyl derivatives are most prominent in increasing activity. Toxicity assays indicated that these derivatives could induce a premature, abnormal, and lethal larval moult.
Mao
Chun-Hui
CH
State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
Wang
Kai-Liang
KL
Wang
Zi-Wen
ZW
Ou
Xiao-Ming
XM
Huang
Run-Qiu
RQ
Bi
Fu-Chun
FC
Wang
Qing-Min
QM
D000818:Animals; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D007306:Insecticides / Q000138:chemical synthesis* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D009036:Moths; D013329:Structure-Activity Relationship
D006834:Hydrazines; D007306:Insecticides; C056565:1,2-dibenzoyl-tert-butylhydrazine; C082026:tebufenozide