title: Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study.
abstract: BACKGROUND
  We examined the relationship between granulocyte, lymphocyte and monocyte counts and risk of coronary heart disease (CHD) and cardiovascular disease (CVD) in men and women. There is paucity of data on the differential leucocyte count and its relationship with the risk of CHD and CVD.
  
  
  METHODS
  This prospective study comprised 7073 men and 9035 women who were 45-79 years of age and were residents of Norfolk. United Kingdom.
  
  
  RESULTS
  During an average of 8 years of follow-up we identified 857 incident CHD events and 2581 CVD incident events. Increased total leucocyte count was associated with increased risk for both CHD and CVD. The highest quartile of granulocyte count was associated with increased risk when compared to lowest quartile for CHD (men HR 1.70 95% CI: 1.30-2.21; women HR 1.24 95% CI: 0.91-1.69) and for CVD (men HR 1.46 95% CI: 1.24-1.71; women HR 1.20 95% CI: 1.02-1.42). The association remained unchanged when the analyses were restricted to nonsmokers and when risk was assessed for every 1000 cells L(-1) increase in cell count. In multivariable models, despite adjusting for C-reactive protein (CRP), the granulocyte count remained an independent predictor of CHD and CVD risk, especially amongst men. Lymphocyte or monocyte counts were not significantly associated with increased risk. In all analyses, additionally adjusting for CRP did not affect the results materially.
  
  
  CONCLUSIONS
  In conclusion, we found that the higher risk for CHD and CVD associated with increased total leucocyte count seems to be accounted for by the increased granulocyte count.
authors: Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors: J S
authors: JS
authors: Rana
authors: S M
authors: SM
authors: Boekholdt
authors: P M
authors: PM
authors: Ridker
authors: J W
authors: JW
authors: Jukema
authors: R
authors: R
authors: Luben
authors: S A
authors: SA
authors: Bingham
authors: N E
authors: NE
authors: Day
authors: N J
authors: NJ
authors: Wareham
authors: J J P
authors: JJ
authors: Kastelein
authors: K-T
authors: KT
authors: Khaw
mesh_terms: D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D003327:Coronary Disease / Q000097:blood* / Q000276:immunology; D003920:Diabetes Mellitus / Q000097:blood; D004739:England; D005260:Female; D006098:Granulocytes / Q000166:cytology*; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012306:Risk; D012737:Sex Factors; D012907:Smoking / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002097:C-Reactive Protein