EBV viral load in tumor tissue is an important prognostic indicator for nasal NK/T-cell lymphoma.
We retrospectively studied 19 cases of nasal NK/T-cell lymphoma for various potential prognostic factors and performed real-time quantitative polymerase chain reaction for Epstein-Barr virus (EBV) viral load in tumor tissue. Patients with a low EBV viral load (<1 copy per cell) more frequently survived for more than 2 years compared with patients with a high EBV viral load (>/=1 copies/cell) (7/7 vs 3/9; P = .014; Fisher exact test). Furthermore, the patients with low EBV viral loads had a better overall survival than patients with high viral loads (50% accumulative survival: not reached vs 4-5 months; Kaplan-Meier survival analysis; P = .049). In contrast, the overall survival of the patients did not correlate with the extent of lesion, age, stage, necrosis, histologic subtypes, CD56 expression, or angiocentric or angiodestructive growth pattern. Our findings suggest that the EBV viral load in tumor tissues is a useful indicator for predicting outcome of nasal NK/T-cell lymphoma.
Hsieh
Pin-Pen
PP
Department of Pathology & Laboratory Medicine, Veterans General Hospital Kaohsiung, Kaohsiung, Taiwan.
Tung
Chun-Liang
CL
Chan
Amy Bik-Wan
AB
Liao
Jia-Bin
JB
Wang
Jyh-Seng
JS
Tseng
Hui-Hwa
HH
Su
Hsing-Hao
HH
Chang
Kun-Chao
KC
Chang
Chung-Che
CC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020031:Epstein-Barr Virus Infections / Q000401:mortality / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D007694:Killer Cells, Natural / Q000821:virology*; D016411:Lymphoma, T-Cell, Peripheral / Q000401:mortality / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000401:mortality / Q000821:virology*; D011379:Prognosis; D012367:RNA, Viral / Q000032:analysis; D012189:Retrospective Studies; D015996:Survival Rate; D019562:Viral Load
D012367:RNA, Viral