title: [Initial study on discrimination of oral microorganisms with the metabonomics technique].
abstract: OBJECTIVE
  To evaluate the feasibility of employing metabonomics method in identification of oral pathogenic bacteria.
  
  
  METHODS
  The Streptococcus mutans ATCC25175 and Actinomyces viscosus ATCC15987 were respectively inoculated in same certain culture medium. The growth curves of the inoculated bacteria were drown by turbidimetry. The culture solutions in four different growth phases of the both bacteria were used to test with the 1H-Nuclear magnetic resonance (1H-NMR) spectroscopy respectively. The data of 1H-NMR spectroscopy results were analyzed by principal components analysis (PCA).
  
  
  RESULTS
  The PCA showed the obvious clustering phenomena and the points of two group data stayed differentially together by two clusters. Therefore, the NMR-based metabonomics profiles can discriminate the two different kind of bacteria.
  
  
  CONCLUSIONS
  The metabonomics can be expected to be a kind of promising useful method in quick discrimination of oral pathogenic bacteria.
authors: Key. Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China.
authors: Miao
authors: M
authors: Li
authors: Li-ying
authors: LY
authors: Xiao
authors: Ji-yao
authors: JY
authors: Li
authors: Xiang-li
authors: XL
authors: Kong
authors: Jia-hui
authors: JH
authors: Yu
authors: Jing-lin
authors: JL
authors: Zhou
authors: Xiao-rong
authors: XR
authors: Xiao
authors: Zhu
authors: Z
authors: Zhu
authors: Qi-mei
authors: QM
authors: Gong
authors: Wei
authors: W
authors: Li
mesh_terms: D003470:Culture Media; D009682:Magnetic Resonance Spectroscopy; D055432:Metabolomics; D013295:Streptococcus mutans
chemical_list: D003470:Culture Media