title: Simple copper salt-catalyzed N-arylation of nitrogen-containing heterocycles with aryl and heteroaryl halides.
abstract: Relatively mild and highly efficient CuI-catalyzed N-arylation procedures for nitrogen-containing heterocycles (e.g., imidazoles, benzimidazoles, pyrroles, pyrazoles, indoles, triazoles, etc.) with aryl and heteroaryl halides have been developed. The protocols can be performed easily and tolerate a number of functional groups, such as ester, nitrile, nitro, ketone, free hydroxyl, and free primary amine on the aryl halide.
authors: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, West China Hospital, Sichuan University, Chengdu 610064, PR China.
authors: Liangbo
authors: L
authors: Zhu
authors: Peng
authors: P
authors: Guo
authors: Gaocan
authors: G
authors: Li
authors: Jingbo
authors: J
authors: Lan
authors: Rugang
authors: R
authors: Xie
authors: Jingsong
authors: J
authors: You
mesh_terms: D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001555:Benzene Derivatives; D006571:Heterocyclic Compounds; D006846:Hydrocarbons, Halogenated; D007454:Iodides; D003300:Copper; C073870:cuprous iodide; D009584:Nitrogen