Thermodynamics of mechanical transduction of surface confined receptor/ligand reactions.
Chemomechanics of surface stress is discussed in terms of interfacial thermodynamics. In the first section the paper shows how to quantitatively describe the chemical equilibrium of a receptor/ligand binding reaction confined at a solid-liquid interface and how the overall work of the reaction splits into chemical and surface work, that appears as a surface pressure. In the second section this thermodynamic model is applied to describe the experimental results of microcantilever bending induced by DNA hybridization occurring onto one of its faces.
Bergese
Paolo
P
INSTM and Chemistry for Technologies Laboratory, University of Brescia, via Branze 38, 25123 Brescia, Italy. paolo.bergese@ing.unibs.it
Oliviero
Giulio
G
Alessandri
Ivano
I
Depero
Laura E
LE
D000937:Antigen-Antibody Reactions; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D017403:In Situ Hybridization; D008024:Ligands; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties; D013816:Thermodynamics
D008024:Ligands; D011506:Proteins; D004247:DNA