[Ion channels and tumor].
This review illuminates the current approaches of ion channels and tumor. Potassium, calcium, chloride channnels and others are abnormally expressed in the membrane of tumor cells. They are crucial for tumor development and growth. By the regulation of membrane voltage, cell cycle, cell volume, Ca2+ signaling and cytosolic pH, they can adjust the cell proliferation and apoptosis. With further study, ion channels will become a new target for cancer therapy and diagnosis.
Jia
Yong-Sheng
YS
Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Wei
Xiao-Li
XL
Zhao
Jie
J
Zheng
Jian-Quan
JQ
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D049109:Cell Proliferation; D002712:Chlorides / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism
D002712:Chlorides; D007473:Ion Channels; D011188:Potassium; D002118:Calcium