Activation of POMC neurons during general arousal but not sexual behavior in male rats.
Exogenous opioids influence male rat sexual behavior, suggesting that endogenous opioid peptides are released during mating. Supporting this hypothesis, the authors recently showed that mating induced activation of mu opioid receptors. However, it is unknown which ligand(s) is acting on these receptors during mating. The current set of experiments tested the hypothesis that beta-endorphin-producing neurons, that is, proopiomelanocortin (POMC) neurons, are activated during sexual behavior. Mating-induced activation of POMC neurons was investigated during either the dark phase or the light phase, following different components of male rat sexual behavior or following control manipulations that resulted in general arousal. Results show activation of POMC neurons in the mediobasal hypothalamus following general arousal but not specifically related to sexual behavior per se. In addition, mating did not activate the subpopulation of POMC neurons that project to the medial preoptic nucleus. These results suggest that it is unlikely that POMC neurons contribute to the action of endogenous opioids in the brain area during sexual behavior but instead may contribute to the change in arousal state essential for the expression of sexual behavior.
Davis
Brooke A
BA
Neuroscience Graduate Program, Department of Cell Biology, University of Cincinnati, Cincinnati, OH, USA.
Fitzgerald
Maureen E
ME
Brown
Jennifer L
JL
Amstalden
Katia A Z
KA
Coolen
Lique M
LM
D000818:Animals; D001143:Arousal / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology; D002452:Cell Count; D003624:Darkness; D004542:Ejaculation / Q000502:physiology; D016762:Genes, fos; D007033:Hypothalamus, Middle / Q000378:metabolism / Q000502:physiology; D007150:Immunohistochemistry; D008027:Light; D008297:Male; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000502:physiology*; D011301:Preoptic Area / Q000502:physiology; D011333:Pro-Opiomelanocortin / Q000096:biosynthesis / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000502:physiology*; D013266:Stilbamidines; D000521:alpha-MSH / Q000096:biosynthesis
C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D013266:Stilbamidines; D000521:alpha-MSH; D011333:Pro-Opiomelanocortin