Effect of chlorophyll and aqueous extracts of Bacopa monniera and Valeriana wallichii on ischaemia and reperfusion-induced cerebral injury in mice.
Bilateral carotid artery occlusion followed by reperfusion produced significant cerebral infarction and impaired short-term memory, motor co-ordination and lateral push response. Individual pretreatments with chlorophyll and aqueous extracts of B. monniera and V. wallichii markedly attenuated ischaemia-reperfusion induced cerebral injury in terms of decreased infarct size, increase in short-term memory, motor in coordination and lateral push response. The results suggest that chlorophyll and aqueous extracts of B. monniera and V. wallichii prevent ischaemia-reperfusion induced cerebral injury with comparable potency.
Rehni
Ashish K
AK
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147 002, Punjab, India. ashishkrehni@yahoo.co.in
Pantlya
Hardeep S
HS
Shri
Richa
R
Singh
Manjeet
M
D000818:Animals; D034681:Bacopa; D002545:Brain Ischemia / Q000188:drug therapy / Q000517:prevention & control*; D002544:Cerebral Infarction / Q000517:prevention & control; D002734:Chlorophyll / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D015427:Reperfusion Injury / Q000188:drug therapy / Q000517:prevention & control*; D014632:Valerian
D010936:Plant Extracts; D002734:Chlorophyll