title: A new method to close the gastrotomy by using a cardiac septal occluder: long-term survival study in a porcine model.
abstract: BACKGROUND
  Closure of the gastrotomy when performing transgastric procedures is one of the most challenging steps to overcome. Several methods of gastric closure have been described, but a simple and safe technique is still lacking.
  
  
  OBJECTIVE
  To evaluate the technical feasibility and safety of a new method of endoscopic gastric closure using a nitinol septal occluder in a porcine survival model.
  
  
  METHODS
  Endoscopic animal experimental study in a porcine survival model.
  
  
  METHODS
  In 6 male pigs under general anesthesia, a 1-cm full-thickness gastrotomy was performed on the anterior body of the stomach and closed with a nitinol septal occluder (Occlutech). Postoperative follow-up included endoscopy and laparoscopy at 1, 2, 4, and 6 weeks after the initial procedure and endoscopy alone at weeks 8, 10, and 12.
  
  
  RESULTS
  All of the gastrotomy closures with the septal occluder were successful. At follow-up endoscopy and laparoscopy there were no signs of adhesions, peritonitis, or perigastric abscess formation at the gastrotomy site. At 12 weeks, 5 of 6 animals were thriving, with appropriate weight gain.
  
  
  CONCLUSIONS
  Endoscopic gastrotomy closure with a septal occluder is technically feasible, safe, and effective in a survival porcine model.
authors: Institut de Recherche contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery, University of Strasbourg, Strasbourg, France.
authors: Silvana
authors: S
authors: Perretta
authors: Stefano
authors: S
authors: Sereno
authors: Antonello
authors: A
authors: Forgione
authors: Bernard
authors: B
authors: Dallemagne
authors: Dimitri
authors: D
authors: Coumaros
authors: Cristoph
authors: C
authors: Boosfeld
authors: Clemens
authors: C
authors: Moll
authors: Jacques
authors: J
authors: Marescaux
mesh_terms: D000497:Alloys; D000818:Animals; D004195:Disease Models, Animal; D004867:Equipment Design; D005240:Feasibility Studies; D005500:Follow-Up Studies; D020699:Gastroscopes; D005773:Gastroscopy / Q000379:methods* / Q000401:mortality; D006346:Heart Septum; D008297:Male; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000295:instrumentation* / Q000401:mortality; D015607:Stents; D013270:Stomach / Q000601:surgery*; D016019:Survival Analysis; D013552:Swine; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000497:Alloys; C013616:nitinol