Macrolactins O-R, glycosylated 24-membered lactones from Bacillus sp. AH159-1.
In the course of screening for inhibitors of Staphylococcus aureus peptide deformylase, four new glycosylated macrolactin compounds, macrolactins O ( 1), P ( 2), Q ( 3), and R ( 4), along with the known macrolactins B ( 5) and C ( 6), have been isolated from the liquid cultures of Bacillus sp. AH159-1. The structures of compounds 1- 4 were assigned on the basis of MS and NMR data. They inhibited S. aureus peptide deformylase and also showed antibacterial activity against Escherichia coli and Staphylococcus aureus.
Zheng
Chang-Ji
CJ
Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon 305-806, Republic of Korea.
Lee
Sangku
S
Lee
Choong-Hwan
CH
Kim
Won-Gon
WG
D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D001407:Bacillus / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D006031:Glycosylation; D007723:Korea; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology
D007783:Lactones; D000581:Amidohydrolases; C084507:peptide deformylase