Acute and chronic dose of alcohol affect the load carrying capacity of long bone in rats.
In the present investigation, the effects of acute and chronic dose of alcohol were evaluated on mechanical properties of long bones of Sprague Dawley rats. In "acute study", 18 animals were divided into three groups containing six animals each, i.e. Group A: control animals, normal saline was given to them intraperitoneally for the period of 5 days; Group B: treated animals, given 20% (v/v) absolute alcohol and Group C: treated animals, given 30% (v/v) absolute alcohol, by same route and time duration. In "chronic study", also, 18 animals were divided into three groups containing six animals each, i.e. Group A: control animals, normal saline was given to them intraperitoneally for the period of 6 weeks; Group B: treated animals, given 20% (v/v) absolute alcohol and Group C: treated animals, given 30% (v/v) absolute alcohol by same route and time duration. A significant increase was observed in bone weight of animals taking 20% alcohol but there was decrease in the same for 30% alcohol in case of acute study. For chronic study, there was a decrease in bone weight for both treated groups. During acute study, breaking strength of bone was increased in case of 20% alcohol administration but a slight decrease was shown in the same for 30% alcohol group as compared to control animals. Breaking strength of long bone in the case of chronic study was decreased in case of both groups taking alcohol, i.e. 20% and 30%. The present document is useful in understanding the functional load carrying capacity of bone during alcoholism.
Rai
D V
DV
Department of Biophysics, Basic Medical Sciences Block, Panjab University, Chandigarh 160014, India. dvrai@pu.ac.in
Kumar
Gaurav
G
Tewari
Priyamvada
P
Saxena
D C
DC
D000428:Alcohol Drinking / Q000009:adverse effects / Q000503:physiopathology*; D000437:Alcoholism / Q000150:complications / Q000503:physiopathology; D000818:Animals; D001696:Biomechanical Phenomena; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity; D005269:Femur / Q000187:drug effects / Q000503:physiopathology*; D050723:Fractures, Bone / Q000209:etiology / Q000503:physiopathology; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical; D013977:Tibia / Q000187:drug effects / Q000503:physiopathology*; D016474:Weight-Bearing / Q000502:physiology*
D000431:Ethanol