Intracellular trafficking of raft/caveolae domains: insights from integrin signaling.
Cells have a complex system for delivering and compartmentalizing proteins and lipids in order to achieve spatio-temporal coordination of signaling. Rafts/caveolae are plasma membrane microdomains that regulate signaling pathways and processes such as cell migration, polarization and proliferation. Regulation of raft/caveolae trafficking involves multiple steps regulated by different proteins to ensure coordination of signaling cascades. The best studied raft-mediated endocytic route is controlled by caveolins. Recent data suggest integrin-mediated cell adhesion is a key regulator of caveolar endocytosis. In this review we examine the regulation of caveolar trafficking and the interplay between integrins, cell adhesion and caveolae internalization.
Echarri
Asier
A
Integrin Signaling Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernández Almagro, 3, 28029 Madrid, Spain.
Muriel
Olivia
O
Del Pozo
Miguel A
MA
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D021941:Caveolae / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology*; D021962:Membrane Microdomains / Q000502:physiology*; D018448:Models, Immunological; D015398:Signal Transduction / Q000502:physiology*
D016023:Integrins