title: Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2.
abstract: Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model.
authors: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. kamil.paruch@spcorp.com
authors: Kamil
authors: K
authors: Paruch
authors: Michael P
authors: MP
authors: Dwyer
authors: Carmen
authors: C
authors: Alvarez
authors: Courtney
authors: C
authors: Brown
authors: Tin-Yau
authors: TY
authors: Chan
authors: Ronald J
authors: RJ
authors: Doll
authors: Kerry
authors: K
authors: Keertikar
authors: Chad
authors: C
authors: Knutson
authors: Brian
authors: B
authors: McKittrick
authors: Jocelyn
authors: J
authors: Rivera
authors: Randall
authors: R
authors: Rossman
authors: Greg
authors: G
authors: Tucker
authors: Thierry O
authors: TO
authors: Fischmann
authors: Alan
authors: A
authors: Hruza
authors: Vincent
authors: V
authors: Madison
authors: Amin A
authors: AA
authors: Nomeir
authors: Yaolin
authors: Y
authors: Wang
authors: Emma
authors: E
authors: Lees
authors: David
authors: D
authors: Parry
authors: Nicole
authors: N
authors: Sgambellone
authors: Wolfgang
authors: W
authors: Seghezzi
authors: Lesley
authors: L
authors: Schultz
authors: Fran
authors: F
authors: Shanahan
authors: Derek
authors: D
authors: Wiswell
authors: Xiaoying
authors: X
authors: Xu
authors: Quiao
authors: Q
authors: Zhou
authors: Ray A
authors: RA
authors: James
authors: Vidyadhar M
authors: VM
authors: Paradkar
authors: Haengsoon
authors: H
authors: Park
authors: Laura R
authors: LR
authors: Rokosz
authors: Tara M
authors: TM
authors: Stauffer
authors: Timothy J
authors: TJ
authors: Guzi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018360:Crystallography, X-Ray; D051357:Cyclin-Dependent Kinase 2 / Q000037:antagonists & inhibitors* / Q000187:drug effects; D004285:Dogs; D004354:Drug Screening Assays, Antitumor; D000882:Haplorhini; D051379:Mice; D023421:Models, Animal; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D023041:Xenograft Model Antitumor Assays
chemical_list: D011720:Pyrazoles; D011725:Pyridines; C447480:pyrazolo(3,4-b)pyridine; D051357:Cyclin-Dependent Kinase 2