title: Candida albicans drug resistance another way to cope with stress.
abstract: There are relatively few classes of antifungal drugs. This restricts clinicians' therapeutic choices and these choices are further reduced by the emergence of drug resistance. Exposure to antifungal drugs represents an environmental stress for the fungal pathogen Candida albicans. The immediate response of C. albicans to antifungals may be drug tolerance, which can lead to drug resistance. This article examines C. albicans drug resistance from the perspective of it being a stress response and investigates how commonality with other stress-response pathways gives insights into the prospects for overcoming, or preventing, drug resistance.
authors: Department of Oral Sciences, University of Otago, Dunedin 9054, New Zealand.
authors: Richard D
authors: RD
authors: Cannon
authors: Department of Oral Sciences, University of Otago, Dunedin 9054, New Zealand.
authors: Erwin
authors: E
authors: Lamping
authors: Department of Oral Sciences, University of Otago, Dunedin 9054, New Zealand.
authors: Ann R
authors: AR
authors: Holmes
authors: Department of Oral Sciences, University of Otago, Dunedin 9054, New Zealand.
authors: Kyoko
authors: K
authors: Niimi
authors: Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo, Japan.
authors: Koichi
authors: K
authors: Tanabe
authors: Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo, Japan.
authors: Masakazu
authors: M
authors: Niimi
authors: Department of Oral Sciences, University of Otago, Dunedin 9054, New Zealand.
authors: Brian C
authors: BC
authors: Monk
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000502:physiology*; D002177:Candidiasis / Q000382:microbiology; D025141:Drug Resistance, Fungal; D006801:Humans
chemical_list: D000935:Antifungal Agents