title: Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans.
abstract: The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with the TaqI A1 allele. Energy intake was greater for individuals high in food reinforcement and greatest in those high in food reinforcement with the TaqI A1 allele. No effect of the DAT1 genotype was observed. These data show that individual differences in food reinforcement may be important for obesity and that the DRD2 genotype may interact with food reinforcement to influence energy intake.
authors: Department of Pediatrics, University at Buffalo, State University of New York, Buffalo, NY 14214-3000, USA. lhenet@acsu.buffalo.edu
authors: Leonard H
authors: LH
authors: Epstein
authors: Jennifer L
authors: JL
authors: Temple
authors: Brad J
authors: BJ
authors: Neaderhiser
authors: Robbert J
authors: RJ
authors: Salis
authors: Richard W
authors: RW
authors: Erbe
authors: John J
authors: JJ
authors: Leddy
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001835:Body Weight / Q000235:genetics / Q000502:physiology; D004247:DNA / Q000235:genetics; D004032:Diet; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics; D002149:Energy Intake / Q000235:genetics* / Q000502:physiology*; D005260:Female; D005502:Food; D005838:Genotype; D006801:Humans; D006815:Hunger / Q000502:physiology; D007206:Individuality; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000523:psychology*; D017448:Receptors, Dopamine D2 / Q000235:genetics* / Q000502:physiology*; D012054:Reinforcement, Psychology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012528:Satiety Response / Q000502:physiology; D011795:Surveys and Questionnaires
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D017448:Receptors, Dopamine D2; C493214:SLC6A3 protein, human; D004247:DNA