title: Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors.
abstract: A facile, one-pot synthesis of thio and selenourea derivatives from amines using tetrathiomolybdate 1 and tetraselenotungstate 2 as sulfur and selenium transfer reagents, respectively, is reported. The compounds were tested for their activity as urease inhibitors and some of the compounds showed potent activity in the nanomolar range towards jack bean urease.
authors: Department of Organic Chemistry, Indian Institute of Science, Bangalore, India.
authors: Kirubakaran
authors: K
authors: Sivapriya
authors: Perumal
authors: P
authors: Suguna
authors: Arun
authors: A
authors: Banerjee
authors: Vadivelu
authors: V
authors: Saravanan
authors: Desirazu N
authors: DN
authors: Rao
authors: Srinivasan
authors: S
authors: Chandrasekaran
mesh_terms: D032449:Canavalia / Q000201:enzymology; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013890:Thiourea / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014510:Urease / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D016566:Organoselenium Compounds; C081959:selenourea; D008982:Molybdenum; D014508:Urea; C020809:tetrathiomolybdate; D014510:Urease; D013890:Thiourea