title: [Effects of high quantities of sorbitol and saccharose in the diet on enzymes activity and liver mass of rats in different seasons of the year].
abstract: Four groups of 1-month-old rats were fed with standard diet (SD) for a month, 46% SD + 54% sorbitol, 54% saccharose or 27% sorbitol + 27% saccharose. Fed with 54% sorbitol and with 27% sorbitol + 27% saccharose differed from rats given 54% saccharose and 100% SD (they were thin, had hyperreaction to light, diarrhea). Liver mass in all the tests in autumn and winter (AuWi) is lower than in spring and summer (SpSu). It is lower in 54% sorbitol, higher in 27% sorbitol + 27% saccharose, the highest in 54% saccharose and 100% SD. Specific activity (SA) of lactate dehydrogenase (LDG) is higher, glucose-6-phosphate dehydrogenase (G-6-PDG) is lower in SpSu than in AuWi in 4 diets. In 54% sorbitol and 27% sorbitol + 27% saccharose SA of LDG, G-6-PDG and succinate dehydrogenase (SDG) is not higher than in 100 SD. SA of SDG and LDG in SpSu is higher than in AuWi, G-6-PDG is lower in SpSu. SA of these three enzymes is not higher in 54% sorbitol than in 100% SD in contrast to 4-fold rise of SA of sorbitol dehydrogenase. Biorhythms of enzyme SA reflect the results of interaction of adaptive molecular mechanisms of the body, including genetic ones, with changing environment.
authors: Iu A
authors: IuA
authors: Petrovich
authors: A I
authors: AI
authors: Volozhin
authors: V A
authors: VA
authors: Zubtsov
authors: S M
authors: SM
authors: Kichenko
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D004032:Diet / Q000009:adverse effects; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012621:Seasons; D013012:Sorbitol / Q000008:administration & dosage / Q000009:adverse effects*; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013395:Sucrose / Q000008:administration & dosage / Q000009:adverse effects*; D013549:Sweetening Agents / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D013549:Sweetening Agents; D013012:Sorbitol; D013395:Sucrose; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase