title: Ring chromosome 12 and severe oligospermia: a case report.
abstract: OBJECTIVE
  To describe an unusual presentation of ring chromosome 12, which manifested as severe azoospermia, resulting in male infertility.
  
  
  METHODS
  Case report.
  
  
  METHODS
  In vitro fertilization center at a tertiary care hospital.
  
  
  METHODS
  A 27-year-old man diagnosed with unexplained azoospermia and ring chromosome 12 abnormality during a workup for primary infertility.
  
  
  METHODS
  In vitro fertilization with preimplantation genetic diagnosis.
  
  
  METHODS
  To confirm the importance of obtaining karyotypes in individuals with severe oligospermia.
  
  
  RESULTS
  Full-term pregnancy after IVF using donor sperm.
  
  
  CONCLUSIONS
  Severe oligospermia and male infertility should be included in the spectrum of findings found in ring chromosome 12.
authors: Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.
authors: J Ryan
authors: JR
authors: Martin
authors: Anne
authors: A
authors: Wold
authors: Hugh S
authors: HS
authors: Taylor
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007316:Insemination, Artificial, Heterologous; D007859:Learning Disabilities / Q000235:genetics; D008297:Male; D008831:Microcephaly / Q000235:genetics; D011247:Pregnancy; D019836:Preimplantation Diagnosis; D012303:Ring Chromosomes