Metal-based netropsin mimics showing AT-selective DNA binding and DNA cleavage activity at red light.
Copper(II) bis-arginate [Cu(l-arg)2](NO3)2 (1) and [Cu(l-arg)(phen)Cl]Cl (2) as mimics of the minor-groove-binding natural antibiotic netropsin show preferential binding to the AT-rich region of double-stranded DNA. The complexes with a d-d band near 600 nm display oxidative DNA cleavage activity on photoirradiation at UV-A light of 365 nm and at red light of 647.1 nm (Ar-Kr laser) in a metal-assisted photoexcitation process forming singlet oxygen (1O2) species in a type-2 pathway.
Patra
Ashis K
AK
Department of Inorganic and Physical Chemistry, and Bioinformatics Center, Department of Physics, Indian Institute of Science, Bangalore, India.
Bhowmick
Tuhin
T
Ramakumar
Suryanarayanarao
S
Chakravarty
Akhil R
AR
D004247:DNA / Q000737:chemistry*; D006868:Hydrolysis; D008027:Light; D008670:Metals / Q000737:chemistry*; D018716:Molecular Mimicry; D009429:Netropsin / Q000737:chemistry*; D011485:Protein Binding
D008670:Metals; D009429:Netropsin; D004247:DNA