title: Antileishmanial, antiplasmodial and cytotoxic activities of 12,16-dideoxy aegyptinone B from Zhumeria majdae Rech.f. & Wendelbo.
abstract: The ethanol extract of Zhumeria majdae showed potent antileishmanial and antiplasmodial activity in vitro. Bioactivity guided fractionation of the extract led to the isolation of 12,16-dideoxy aegyptinone B. This compound exhibited potent in vitro antileishmanial activity with an IC(50) of 0.75 microg/mL and a strong antiplasmodial activity with IC(50) values of 1.3 and 1.4 microg/mL against chloroquine sensitive and resistant strains, respectively. This compound was further found to have mild cytotoxicity towards cancer cell lines.
authors: Department of Pharmacognosy, Faculty of Pharmacy, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran.
authors: Mahmood Reza
authors: MR
authors: Moein
authors: Rahul S
authors: RS
authors: Pawar
authors: Shabana I
authors: SI
authors: Khan
authors: Babu L
authors: BL
authors: Tekwani
authors: Ikhlas A
authors: IA
authors: Khan
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D000431:Ethanol / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D019686:Lamiaceae / Q000737:chemistry*; D007893:Leishmania donovani / Q000187:drug effects*; D051379:Mice; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D018675:Toxicity Tests; D014709:Vero Cells
chemical_list: C533493:12,16-dideoxyaegyptinone B; D000981:Antiprotozoal Agents; D004224:Diterpenes; D009285:Naphthoquinones; D010936:Plant Extracts; D000431:Ethanol