title: Effect of cold air cooling on the incidence of postinflammatory hyperpigmentation after Q-switched Nd:YAG laser treatment of acquired bilateral nevus of Ota like macules.
abstract: OBJECTIVE
  To investigate the effect of cold air cooling on the incidence of postinflammatory hyperpigmentation (PIH) after laser treatment in Asian patients.
  
  
  METHODS
  Randomized, controlled, split-face study.
  
  
  METHODS
  Skin laser center of a university hospital.
  
  
  METHODS
  Twenty-three Thai women with acquired bilateral nevus of Ota-like macules.
  
  
  METHODS
  Patients were treated using a 1064-nm Q-switched Nd:YAG laser at an average fluence of 7.0 J/cm(2) using a 3-mm spot size. The same laser fluence was used on both sides of the face in individual patients. One randomly selected face side of each patient was cooled using a cold air cooling device during and 30 seconds before and after laser irradiation, and the other side was irradiated without cooling.
  
  
  METHODS
  Occurrence of PIH was objectively evaluated by measuring the melanin index using a spectrometer, and it was subjectively assessed by 2 nontreating physicians before treatment and once weekly for 4 weeks.
  
  
  RESULTS
  Of the 21 patients who completed the study, 13 (62%) and 5 (24%) developed PIH on the cooled and uncooled sides, respectively. One patient (5%) had PIH on both the cooled and uncooled sides, and 2 (10%) did not experience PIH. The cooled sides were significantly more likely to become hyperpigmented after laser irradiation than the uncooled sides (relative risk, 2.6; 95% confidence interval, 1.13-6.00; P = .03). The clinical evaluation corresponded to the spectrometer reading.
  
  
  CONCLUSIONS
  Epidermal cooling with cold air is associated with an increased risk of PIH after Q-switched Nd:YAG laser treatment.
  
  
  BACKGROUND
  clinicaltrials.gov Identifier: NCT00287001.
authors: Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Pran-nok Rd, Bangkok 10700, Thailand. siwmn@mahidol.ac.th
authors: Woraphong
authors: W
authors: Manuskiatti
authors: Sasima
authors: S
authors: Eimpunth
authors: Rungsima
authors: R
authors: Wanitphakdeedecha
mesh_terms: D000328:Adult; D000368:Aged; D003080:Cold Temperature / Q000009:adverse effects*; D005153:Facial Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology*; D028022:Low-Level Light Therapy / Q000009:adverse effects* / Q000379:methods; D008875:Middle Aged; D009507:Nevus of Ota / Q000532:radiotherapy*; D012878:Skin Neoplasms / Q000532:radiotherapy*