title: Preparation and characterization of etoricoxib-beta-cyclodextrin complexes prepared by the kneading method.
abstract: The binary system of etoricoxib with beta-cyklodextrin (beta-CD) was prepared by the kneading method. Drug-cyclodextrin interactions in solution were investigated by the phase solubility analysis. Differential scanning calorimetry, infrared spectroscopy, powder X-ray diffractometry and microscopic study were used to characterize the solid state of all binary systems, whereas their dissolution properties were evaluated according to the USP XXIII paddle method. The results indicate partial interaction of the drug with beta-CD in the physical mixture and complete interaction in the kneaded complex. The dissolution of etoricoxib was notably increased as compared to pure drug as well as its physical mixture. The complex showed more than 75% drug released in 30 min.
authors: Department of Quality Assurance, L. M. College of Pharmacy, Navrangpura, Ahmedabad-380009 India. patelhary@rediffmail.com
authors: Haresh M
authors: HM
authors: Patel
authors: Bhanubhai N
authors: BN
authors: Suhagia
authors: Shailesh A
authors: SA
authors: Shah
authors: Ishwar Sinh
authors: IS
authors: Rathod
authors: Vijay K
authors: VK
authors: Parmar
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods*; D000077613:Etoricoxib; D033362:Powder Diffraction; D011725:Pyridines / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013450:Sulfones / Q000737:chemistry* / Q000493:pharmacokinetics; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D016861:Cyclooxygenase Inhibitors; D011725:Pyridines; D013450:Sulfones; D047392:beta-Cyclodextrins; C031215:betadex; D000077613:Etoricoxib