title: Antiobesity effect of trans-10,cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice.
abstract: OBJECTIVE
  To observe the antiobesity activity of trans-10,cis-12-conjugated linoleic acid (CLA)-producing lactobacillus in mice.
  
  
  RESULTS
  Lactobacillus plantarum PL62, which can grow in the presence of linoleic acid, was selected and studied. The culture supernatant of Lact. plantarum PL62 contained trans-10,cis-12-conjugated linoleic acid (6.4 microg ml(-1)), and the crude enzyme prepared from washed cells produced trans-10,cis-12 CLA (1395 microg mg(-1) protein). Lact. plantarum PL62 reduced the weights of epididymal, inguinal, mesenteric, and perirenal white adipose tissues and significantly reduced the blood levels of total glucose and body weights of mice (P<0.01).
  
  
  CONCLUSIONS
  trans-10,cis-12-CLA-producing Lact. plantarum PL62 can exert the same antiobesity activity as trans-10,cis-12-CLA in mice.
  
  
  CONCLUSIONS
  trans-10,cis-12-CLA-producing Lactobacillus can be a replacement for CLA for obesity treatment via the continuous production of trans-10,cis-12-CLA. The results provide a novel opportunity to develop foods with antiobesity activity.
authors: Culture Collection of Antimicrobial Resistant Microbes, Department of Biology, Seoul Women's University, Seoul, Korea.
authors: K
authors: K
authors: Lee
authors: K
authors: K
authors: Paek
authors: H Y
authors: HY
authors: Lee
authors: J H
authors: JH
authors: Park
authors: Y
authors: Y
authors: Lee
mesh_terms: D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D004041:Dietary Fats / Q000008:administration & dosage; D004435:Eating; D002149:Energy Intake; D005243:Feces / Q000382:microbiology; D005990:Glycerol / Q000097:blood; D048191:Lactiplantibacillus plantarum / Q000302:isolation & purification / Q000378:metabolism*; D020738:Leptin / Q000097:blood; D044243:Linoleic Acids, Conjugated / Q000096:biosynthesis*; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D009929:Organ Size; D019936:Probiotics / Q000627:therapeutic use*; D015430:Weight Gain
chemical_list: D004041:Dietary Fats; D020738:Leptin; D044243:Linoleic Acids, Conjugated; D008055:Lipids; C496197:trans-10,cis-12-conjugated linoleic acid; D005990:Glycerol