title: Efficacy of n-3 polyunsaturated fatty acids according to clinical characteristics of patients with recent myocardial infarction: insights from the GISSI-Prevenzione trial.
abstract: The GISSI-Prevenzione trial established the efficacy of n-3 polyunsaturated fatty acids (PUFAs) for reducing mortality in patients after recent myocardial infarction. The generalisability of such results to clinical practice could vary according to other individual patient characteristics. We analysed the GISSI-Prevenzione database to assess whether other major risk factors, comorbidities, dietary habits, or medications could interact with the efficacy of n-3 PUFA treatment to reduce total mortality. We found no evidence that concomitant disease states, habits, or interventions altered the therapeutic benefit of n-3 PUFA consumption in survivors of recent myocardial infarction.
authors: Consorzio Mario Negri Sud, Santa Maria Imbaro (CH), Italy. marchioli@negrisud.it
authors: Roberto
authors: R
authors: Marchioli
authors: Rosa Maria
authors: RM
authors: Marfisi
authors: Giovanna
authors: G
authors: Borrelli
authors: Carmelo
authors: C
authors: Chieffo
authors: Maria Grazia
authors: MG
authors: Franzosi
authors: Giacomo
authors: G
authors: Levantesi
authors: Aldo Pietro
authors: AP
authors: Maggioni
authors: Gian Luigi
authors: GL
authors: Nicolosi
authors: Marco
authors: M
authors: Scarano
authors: Maria Giuseppina
authors: MG
authors: Silletta
authors: Carlo
authors: C
authors: Schweiger
authors: Luigi
authors: L
authors: Tavazzi
authors: Gianni
authors: G
authors: Tognoni
mesh_terms: D003920:Diabetes Mellitus / Q000453:epidemiology; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D009203:Myocardial Infarction / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D055502:Secondary Prevention; D013318:Stroke Volume; D018879:Ventricular Premature Complexes / Q000453:epidemiology; D014810:Vitamin E / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D015525:Fatty Acids, Omega-3; D014815:Vitamins; D014810:Vitamin E