HLA-A, -B and -DR allele and haplotype frequencies in Malays.
One thousand four hundreds and forty-five Malays registered with the Malaysian Marrow Donor Registry were typed for HLA-A, HLA-B and HLA-DR. Fifteen HLA-A, twenty nine HLA-B and fourteen HLA-DR alleles were detected. The most common HLA-A alleles and their frequencies were HLA-A24 (0.35), HLA-A11 (0.21) and HLA-A2 (0.15). The most common HLA-B alleles were HLA-B15 (0.26), HLA-B35 (0.11) and HLA-B18 (0.10) while the most common HLA-DR alleles were HLA-DR15 (0.28), HLA-DR12 (0.27) and HLA-DR7 (0.10). A24-B15-DR12 (0.047), A24-B15-DR15 (0.03) and the A24-B35-DR12 (0.03) were the most frequent haplotypes. This data may be useful in determining the probability of finding a matched donor and for estimating the incidence of HLA associated diseases.
Dhaliwal
J S
JS
Allergy and Immunology Research Centre, Institute for Medical Research, 50588 Kuala Lumpur, Malaysia. jasbir@imr.gov.my
Shahnaz
M
M
Too
C L
CL
Azrena
A
A
Maiselamah
L
L
Lee
Y Y
YY
Irda
Y A
YA
Salawati
M
M
D000483:Alleles; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008296:Malaysia; D008297:Male
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens