title: Draft genome of the filarial nematode parasite Brugia malayi.
abstract: Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the approximately 90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict approximately 11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during approximately 350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design.
authors: Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. GhedinE@dom.pitt.edu
authors: Elodie
authors: E
authors: Ghedin
authors: Shiliang
authors: S
authors: Wang
authors: David
authors: D
authors: Spiro
authors: Elisabet
authors: E
authors: Caler
authors: Qi
authors: Q
authors: Zhao
authors: Jonathan
authors: J
authors: Crabtree
authors: Jonathan E
authors: JE
authors: Allen
authors: Arthur L
authors: AL
authors: Delcher
authors: David B
authors: DB
authors: Guiliano
authors: Diego
authors: D
authors: Miranda-Saavedra
authors: Samuel V
authors: SV
authors: Angiuoli
authors: Todd
authors: T
authors: Creasy
authors: Paolo
authors: P
authors: Amedeo
authors: Brian
authors: B
authors: Haas
authors: Najib M
authors: NM
authors: El-Sayed
authors: Jennifer R
authors: JR
authors: Wortman
authors: Tamara
authors: T
authors: Feldblyum
authors: Luke
authors: L
authors: Tallon
authors: Michael
authors: M
authors: Schatz
authors: Martin
authors: M
authors: Shumway
authors: Hean
authors: H
authors: Koo
authors: Steven L
authors: SL
authors: Salzberg
authors: Seth
authors: S
authors: Schobel
authors: Mihaela
authors: M
authors: Pertea
authors: Mihai
authors: M
authors: Pop
authors: Owen
authors: O
authors: White
authors: Geoffrey J
authors: GJ
authors: Barton
authors: Clotilde K S
authors: CK
authors: Carlow
authors: Michael J
authors: MJ
authors: Crawford
authors: Jennifer
authors: J
authors: Daub
authors: Matthew W
authors: MW
authors: Dimmic
authors: Chris F
authors: CF
authors: Estes
authors: Jeremy M
authors: JM
authors: Foster
authors: Mehul
authors: M
authors: Ganatra
authors: William F
authors: WF
authors: Gregory
authors: Nicholas M
authors: NM
authors: Johnson
authors: Jinming
authors: J
authors: Jin
authors: Richard
authors: R
authors: Komuniecki
authors: Ian
authors: I
authors: Korf
authors: Sanjay
authors: S
authors: Kumar
authors: Sandra
authors: S
authors: Laney
authors: Ben-Wen
authors: BW
authors: Li
authors: Wen
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authors: Li
authors: Tim H
authors: TH
authors: Lindblom
authors: Sara
authors: S
authors: Lustigman
authors: Dong
authors: D
authors: Ma
authors: Claude V
authors: CV
authors: Maina
authors: David M A
authors: DM
authors: Martin
authors: James P
authors: JP
authors: McCarter
authors: Larry
authors: L
authors: McReynolds
authors: Makedonka
authors: M
authors: Mitreva
authors: Thomas B
authors: TB
authors: Nutman
authors: John
authors: J
authors: Parkinson
authors: José M
authors: JM
authors: Peregrín-Alvarez
authors: Catherine
authors: C
authors: Poole
authors: Qinghu
authors: Q
authors: Ren
authors: Lori
authors: L
authors: Saunders
authors: Ann E
authors: AE
authors: Sluder
authors: Katherine
authors: K
authors: Smith
authors: Mario
authors: M
authors: Stanke
authors: Thomas R
authors: TR
authors: Unnasch
authors: Jenna
authors: J
authors: Ware
authors: Aguan D
authors: AD
authors: Wei
authors: Gary
authors: G
authors: Weil
authors: Deryck J
authors: DJ
authors: Williams
authors: Yinhua
authors: Y
authors: Zhang
authors: Steven A
authors: SA
authors: Williams
authors: Claire
authors: C
authors: Fraser-Liggett
authors: Barton
authors: B
authors: Slatko
authors: Mark L
authors: ML
authors: Blaxter
authors: Alan L
authors: AL
authors: Scott
mesh_terms: D000818:Animals; D017178:Brugia malayi / Q000235:genetics* / Q000502:physiology; D002107:Caenorhabditis / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics; D004351:Drug Resistance / Q000235:genetics; D005368:Filariasis / Q000469:parasitology; D049751:Genome, Helminth; D006801:Humans; D008969:Molecular Sequence Data