An 85-year-old case with Hashimoto's encephalopathy, showing spontaneous complete remission.
We report an 85-year-old man with Hashimoto's encephalopathy (HE) who showed spontaneous complete remission. The autoantibody against the amino (NH2) terminal region of alpha-enolase was positive in our patient. Neuropsychological manifestations, such as personality change and progressive cognitive impairment, gradually improved over approximately 6 weeks after onset of disease without corticosteroid treatment in parallel with a decrease in the anti-thyroglobulin antibody in the cerebrospinal fluid. HE should be considered as a possible diagnosis even in elderly patients with neuropsychiatric symptoms, particularly when a previous history of thyroid disease is present.
Katoh
Nagaaki
N
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto.
Yoshida
Takuhiro
T
Shimojima
Yasuhiro
Y
Gono
Takahisa
T
Matsuda
Masayuki
M
Yoneda
Makoto
M
Ikeda
Shu-ichi
S
D000369:Aged, 80 and over; D050031:Hashimoto Disease / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D006801:Humans; D008297:Male; D012075:Remission, Spontaneous