Peroxiredoxins in malaria parasites: parasitologic aspects.
Malaria is one of the most debilitating and life threatening diseases in tropical regions of the world. Over 500 million clinical cases occur, and 2-3 million people die of the disease each year. Because Plasmodium lacks genuine glutathione peroxidase and catalase, the two major antioxidant enzymes in the eukaryotic cell, malaria parasites are likely to utilize members of the peroxiredoxin (Prx) family as the principal enzymes to reduce peroxides, which increase in the parasite cell due to metabolism and parasitism during parasite development. In addition to its function of protecting macromolecules from H(2)O(2), Prx has also been reported to regulate H(2)O(2) as second messenger in transmission of redox signals, which mediate cell proliferation, differentiation, and apoptosis. In the malaria parasite, several lines of experimental data have suggested that the parasite uses Prxs as multifunctional molecules to adapt themselves to asexual and sexual development. In this review, we summarize the accumulated knowledge on the Prx family with respect to their functions in mammalian cells and their possible function(s) in malaria parasites.
Kawazu
Shin-ichiro
S
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, 2-13 Inada-cho, Obihiro, Hokkaido 080-8555, Japan. skawazu@obihiro.ac.jp
Komaki-Yasuda
Kanako
K
Oku
Hiroyuki
H
Kano
Shigeyuki
S
D000818:Animals; D006790:Host-Parasite Interactions; D006801:Humans; D008288:Malaria / Q000201:enzymology / Q000469:parasitology*; D051379:Mice; D054464:Peroxiredoxins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D010961:Plasmodium / Q000201:enzymology* / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013879:Thioredoxins / Q000502:physiology
D017382:Reactive Oxygen Species; D013879:Thioredoxins; D054464:Peroxiredoxins