title: Spindle cell hemangioma: report of a case presenting in the oral cavity.
abstract: BACKGROUND
  Spindle cell hemangioma, formerly termed spindle cell hemangioendothelioma, is an uncommon benign vascular tumor. Presentation in the oral cavity is rare with only two previously reported cases.
  
  
  METHODS
  We report a case of spindle cell hemangioma that presented as an asymptomatic mass of the buccal mucosa in a 44-year-old man.
  
  
  RESULTS
  The tumor was a well-circumscribed vascular proliferation of spindled to epithelioid endothelial cells. Tumor cells with intracytoplasmic vascular lumens were present in several areas. Larger, ectatic, thin-walled vessels lined by a single layer of flattened endothelial cells were evident at the periphery and focally in more cellular areas. The tumor was positive for CD31 and CD34.
  
  
  CONCLUSIONS
  Spindle cell hemangioma rarely presents in the oral cavity and needs to be considered in the differential diagnosis of oral cavity vascular tumors to avoid misdiagnosis as a more aggressive vascular tumor.
authors: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA. mpsheeha@iupui.edu
authors: Michael
authors: M
authors: Sheehan
authors: Sheila O
authors: SO
authors: Roumpf
authors: Don-John
authors: DJ
authors: Summerlin
authors: Steven D
authors: SD
authors: Billings
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis; D006391:Hemangioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006394:Hemangiosarcoma / Q000175:diagnosis; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D012514:Sarcoma, Kaposi / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor