title: Biocompatible poly(methylidene malonate)-made materials for pharmaceutical and biomedical applications.
abstract: In the past 20 years, mainly with the sponsorship of Laboratoires UPSA (France) and, afterwards, its spin-off company Virsol (France), several authors have studied methylidene malonate-based polymers used in drug delivery approaches and in the development of novel biomaterials. The present paper aims at summing up the preparation of methylidene malonate monomers, and essentially a novel asymmetric diester structure: 1-ethoxycarbonyl-1-ethoxycarbonylmethylenoxycarbonyl ethene named methylidene malonate 2.1.2. Their polymeric and copolymeric derivatives and a few of their applications which were reported in the literature are also presented. It encompasses the manufacturing of particulate systems such as nano- and macroparticles designed for the delivery of hydrophilic or hydrophobic drugs and biomolecules. This review article also describes their use as biomaterials of interest in the fields of tissue repair, as drug reservoirs or ophthalmology, as implants. Copolymers based on these monomers offer a large range of properties and could be used as new surfactants, micellar vectors, or particulate systems for gene delivery. Therefore, this review, certainly the first dedicated exclusively to methylidene malonate-based materials, highlights the great biomedical and pharmaceutical technology potential of these new materials.
authors: VIRSOL, Paris, France.
authors: Pascal
authors: P
authors: Breton
authors: Virginie
authors: V
authors: Larras
authors: Didier
authors: D
authors: Roy
authors: Serge
authors: S
authors: Sagodira
authors: David
authors: D
authors: Limal
authors: David
authors: D
authors: Bonnafous
authors: Nathalie
authors: N
authors: Colin
authors: Nicole
authors: N
authors: Bru
authors: Elias
authors: E
authors: Fattal
authors: Patrick
authors: P
authors: Couvreur
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D005472:Fluorouracil / Q000008:administration & dosage; D018014:Gene Transfer Techniques; D008314:Malonates / Q000008:administration & dosage*; D011095:Polyethylenes / Q000008:administration & dosage*; D013536:Suture Techniques / Q000295:instrumentation; D014222:Triamcinolone Acetonide / Q000008:administration & dosage
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D008314:Malonates; D011095:Polyethylenes; C091414:poly(methylidene malonate) 2.1.2; D014222:Triamcinolone Acetonide; D005472:Fluorouracil