title: Quantitative and diffusion MR imaging as a new method to assess osteoporosis.
abstract: OBJECTIVE
  The role of advanced MR imaging techniques in demonstrating the microarchitectural changes in osteoporosis has been recently investigated. Our aim was to determine the role of quantitative and diffusion MR imaging in the diagnosis of osteoporosis compared with dual-energy x-ray absorptiometry (DEXA).
  
  
  METHODS
  Fifty-one subjects underwent both DEXA and conventional MR imaging with diffusion and apparent diffusion coefficient (ADC) mapping. T1, T2, diffusion signal intensity, and ADC values were calculated and compared with bone mineral attenuation (BMD). Results were obtained from L1 to L4 of each patient with a total of 204 lumbar vertebrae.
  
  
  RESULTS
  Both T1 and T2 signal intensities tended to increase when both diffusion and ADC values decreased with reducing BMD.
  
  
  CONCLUSIONS
  An inverse relationship between BMD and T1 and T2 signal intensities and a direct relationship between diffusion and ADC values were present in this pilot group. The T1/diffusion signal-intensity ratio could be a reliable diagnostic indicator of osteoporosis.
authors: Department of Radiology, Ankara Numune Education and Research Hospital, Ankara, Turkey. gulhatip@yahoo.com
authors: H G
authors: HG
authors: Hatipoglu
authors: A
authors: A
authors: Selvi
authors: D
authors: D
authors: Ciliz
authors: E
authors: E
authors: Yuksel
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis*