Sirolimus for visceral and cutaneous Kaposi's sarcoma in a renal-transplant recipient.
The incidence of Kaposi's sarcoma among recipients of solid organs is about 500 times the rate in the general population, suggesting a role for immunosuppression in its development. On the basis of these findings, we investigated the impact of sirolimus on cutaneous and disseminated visceral Kaposi's sarcoma in a renal-transplant recipient. The introduction of sirolimus in this patient allowed complete regression of Kaposi's sarcoma (cutaneous and visceral) with preservation of excellent renal function. Meanwhile, in view of the available observational reports, we think that sirolimus should be included in the standard treatment for Kaposi's sarcoma after transplantation, to permit remission of the sarcoma (both cutaneous and visceral) while preserving the renal function.
Gheith
Osama
O
Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
Bakr
Adel
A
Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt. adelbakr2001@yahoo.com.
Wafa
Ehab
E
Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
Fouda
Ashraf
A
Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
El Agroudy
Amgad
A
Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
Refaie
Ayman
A
Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
Donia
Ahmed
A
Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
Sabry
Alaa
A
Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
Sobh
Mohamed
M
Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
Shokeir
Ahmed
A
Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
Ghoneim
Mohamed
M
Urology and Nephrology Center, Mansoura University, Gomhoria St. Mansoura, Egypt.
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000209:etiology; D020123:Sirolimus / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000209:etiology; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000209:etiology
D000903:Antibiotics, Antineoplastic; D020123:Sirolimus