IL-23 and IL-17 have a multi-faceted largely negative role in fungal infection.
The role of IL-23 and IL-17 in the response to fungal infection has been the focus of recent reports. In this issue of the European Journal of Immunology there is an article that reports an important role for IL-23 and IL-17 in limiting fungal control, promoting neutrophillic inflammation and regulating the killing activity of neutrophils. In the fungal model it appears that IL-23 and IL-17 are counter-productive for protection.
Cooper
Andrea M
AM
Trudeau Institute, Saranac Lake, NY 12983, USA. acooper@trudeauinstitute.org
D000818:Animals; D006801:Humans; D020381:Interleukin-17 / Q000502:physiology*; D053759:Interleukin-23 / Q000502:physiology*; D009181:Mycoses / Q000276:immunology / Q000378:metabolism*
D020381:Interleukin-17; D053759:Interleukin-23