Total antioxidant status in type 2 diabetic patients: experience at University College Hospital (UCH) Ibadan, Nigeria.
Total antioxidant status (TAS) was measured in 20 Type 2 diabetic patients aged 40-60 years (mean 50 years). Patients were on diet and oral hypoglycemic drug therapy, with fasting plasma glucose (FPG) levels > 7.0 mmol/L. Similar measurements were carried out in 20 apparently healthy individuals within the same age range (mean 46 years) and with FPG levels < 6.1 mmol/L. FPG was measured by glucose oxidase method and TAS by a colourimetric method. Comparing the two groups, TAS was significantly reduced in the Type 2 diabetic patients (0.96 +/- 0.37 Vs 1.61 +/- 0.16 mmol/L) (P < 0.05). An inverse correlation between FPG and TAS suggested the existence of a lower antioxidant defense in poorly controlled Type 2 diabetics. Good control of FPG, could possibly help reduce free radical activity and probably minimize the chronic complications in diabetic patients.
Akinosun
O M
OM
Department of Chemical Pathology, University College Hospital Ibadan, Nigeria.
Bolajoko
E B
EB
D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D001786:Blood Glucose; D015992:Body Mass Index; D016022:Case-Control Studies; D048909:Diabetes Complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D005215:Fasting; D005260:Female; D005609:Free Radicals; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D017382:Reactive Oxygen Species / Q000032:analysis
D000975:Antioxidants; D001786:Blood Glucose; D005609:Free Radicals; D017382:Reactive Oxygen Species