Alfuzosin-induced acute liver injury.
We describe a 56-year-old man who developed an acute liver injury after taking alfuzosin for 1 month to control his newly diagnosed benign prostatic hypertrophy (BPH). There was no history of alcohol consumption or the taking herbal or traditional remedies. Viral causes, autoimmune hepatitis, and biliary tree obstruction were excluded. Other rare causes of hepatitis such as hemochromatosis, primary biliary cirrhosis and Wilson's disease were also absent in this patient. His liver test results began to improve after discontinuing the alfuzosin. Two weeks later, alfuzosin was administered again because the patient complained of dysuria. After 10 days of alfuzosin reuse, his liver test results worsened. Five months later after the complete discontinuation of the drug, his liver test results had returned to normal. This clinical sequence suggests that alfuzosin caused his acute liver injury.
Kim
Seok Yeon
SY
Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Kim
Byung Ho
BH
Dong
Seok Ho
SH
Kim
Hyo Jong
HJ
Chang
Young Woon
YW
Chang
Rin
R
Kim
Yoon Wha
YW
D000208:Acute Disease; D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D053159:Dysuria / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000188:drug therapy; D011799:Quinazolines / Q000009:adverse effects*
D000317:Adrenergic alpha-Antagonists; D011799:Quinazolines; C047638:alfuzosin