Oxidative stress in endometrial hyperplasia.
OBJECTIVE
Reactive oxygen species seem to be involved in the onset and promotion of carcinogenesis. In 80% of cases of endometrial adenocarcinoma type I, a clear association exists with endometrial hyperplasia, which is considered a key factor in the endometrial oncological spectrum. The presence or absence of atypical cells determines oncological potential. This study explored the behavior of oxidative stress (catalase and malondialdehyde) in endometrial hyperplasia (with or without atypical cells) by comparing it with the oxidative stress existing in both the proliferative and secretory phases.


METHODS
Endometrial specimens from 55 women were used, 32 of which were histologically diagnosed as physiological (17 proliferative and 15 secretory endometria) and 23 as endometrial hyperplasia (18 nonatypical and 5 atypical endometrial hyperplasia).


RESULTS
Significant differences were found in the malondialdehyde variable between the proliferative endometrium and the endometrium with atypical hyperplasia (P = 0.0208) and between both types of endometrial hyperplasia (P = 0.0441). The other comparisons were not statistically significant. No changes in catalase activity were observed.


CONCLUSIONS
Our findings seem to suggest that the presence of atypical cells in endometrial hyperplasia induces a reduction in lipid peroxidation, which could permit survival and growth of these cells. This possible decrease in lipid peroxidation does not seem to be mediated by an increase in endometrial catalase activity.
Gómez-Zubeldia
María Angeles
MA
Department of Nursing, University of Extremadura, Badajoz, Spain.
Bazo
Ascensión Pérez
AP
Gabarre
Juan José Arbués
JJ
Nogales
Agustín García
AG
Palomino
José Carlos Millán
JC
D000328:Adult; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism; D004714:Endometrial Hyperplasia / Q000378:metabolism* / Q000473:pathology*; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005498:Follicular Phase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008183:Luteal Phase / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*
D008315:Malondialdehyde; D002374:Catalase