title: Minor limonoids from Melia toosendan and their antibacterial activity.
abstract: In this study five new limonoids, toosendone [24,25,26,27-tetra-nor-6alpha-acetoxy-21,22-epoxy-7alpha-tigloyl-1alpha,3alpha,28-trihydroxyapotirucalla-(apoeupha)-14,20,22-trien-12-one, 1] and 12-ethoxynimbolinins A-D (2-5), together with five known limonoids, 1-acetyltrichilinin (6), 1-cinnamoyltrichilinin (7), trichilinin B (8), 1,7-di-O-acetyl-14,15-deoxyhavanensin (9) and 12-O-methylnimbolinin B (10),were isolated from the fruits of Melia toosendan. Their structures and relative configurations were established based on spectroscopic analysis. Compound 4 exhibited significant antibacterial activity against the oral pathogen, Porphyromonas gingivalis ATCC 33 277, with an MIC value of 15.6 microg/mL. Compounds 7 and 8 were also active against P. gingivalis ATCC 33 277, with MIC values of 31.3 and 31.5 microg/mL respectively.
authors: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China.
authors: Qiong
authors: Q
authors: Zhang
authors: Yao
authors: Y
authors: Shi
authors: Xue-Ting
authors: XT
authors: Liu
authors: Jing-Yu
authors: JY
authors: Liang
authors: Nancy Y
authors: NY
authors: Ip
authors: Zhi-Da
authors: ZD
authors: Min
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031585:Melia / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009055:Mouth / Q000382:microbiology; D010946:Plants, Medicinal / Q000737:chemistry; D016966:Porphyromonas gingivalis / Q000187:drug effects*; D013295:Streptococcus mutans / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D036701:Limonins