The potential of peroxisome proliferator-activated receptor gamma (PPARgamma) ligands in the treatment of hematological malignancies.
PPARgamma has emerged as a key regulator of cell growth and survival, whose activity is modulated by a number of synthetic and natural ligands. Here we shall review the activities of PPARgamma ligands in the control of immune cell proliferation, differentiation and apoptosis and their potential therapeutic applications to hematological malignancies.
Ulivieri
C
C
Department of Evolutionary Biology, Via Aldo Moro 2, 53100 Siena, Italy.
Baldari
C T
CT
D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006801:Humans; D007111:Immunity, Cellular; D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism
D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors