title: Solid-phase synthesis and modification of Thiazole Orange and its derivatives and their spectral properties.
abstract: A new solid-phase synthesis is shown to be effective in the preparation of cyanine dye Thiazole Orange (TO) and its derivatives, which can be obtained as a traceless cleavage of the Merrifield resin method. The influence of different solvents, substitutional groups, introduced to benzothiazole such as chlorine, methyl, and nitro was extensively studied. The changes of the special characteristic and fluorescence intensity of the TO derivatives were described. The phenomenon of the synergetic effect was also depicted after modifying the TO molecule with chitosan oligosaccharide (CTS) at the end of the alkyl, which can effectively improve the sensitivity of the fluorescent probe.
authors: Department of Material Science and Engineering, Tianhin Institute of Urban Construction, Tianjin, 300384, China. feixuening@eyou.com
authors: Xuening
authors: X
authors: Fei
authors: Shaobin
authors: S
authors: Yang
authors: Baolian
authors: B
authors: Zhang
authors: Zhijun
authors: Z
authors: Liu
authors: Yingchun
authors: Y
authors: Gu
mesh_terms: D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared; D013696:Temperature
chemical_list: D052160:Benzothiazoles; D005456:Fluorescent Dyes; D011804:Quinolines; D012997:Solvents; C051000:thiazole orange; C005465:benzothiazole