Auditory cortical receptive fields: stable entities with plastic abilities.
To form a reliable, consistent, and accurate representation of the acoustic scene, a reasonable conjecture is that cortical neurons maintain stable receptive fields after an early period of developmental plasticity. However, recent studies suggest that cortical neurons can be modified throughout adulthood and may change their response properties quite rapidly to reflect changing behavioral salience of certain sensory features. Because claims of adaptive receptive field plasticity could be confounded by intrinsic, labile properties of receptive fields themselves, we sought to gauge spontaneous changes in the responses of auditory cortical neurons. In the present study, we examined changes in a series of spectrotemporal receptive fields (STRFs) gathered from single neurons in successive recordings obtained over time scales of 30-120 min in primary auditory cortex (A1) in the quiescent, awake ferret. We used a global analysis of STRF shape based on a large database of A1 receptive fields. By clustering this STRF space in a data-driven manner, STRF sequences could be classified as stable or labile. We found that >73% of A1 neurons exhibited stable receptive field attributes over these time scales. In addition, we found that the extent of intrinsic variation in STRFs during the quiescent state was insignificant compared with behaviorally induced STRF changes observed during performance of spectral auditory tasks. Our results confirm that task-related changes induced by attentional focus on specific acoustic features were indeed confined to behaviorally salient acoustic cues and could be convincingly attributed to learning-induced plasticity when compared with "spontaneous" receptive field variability.
Elhilali
Mounya
M
Center for Auditory and Acoustic Research, Institute for Systems Research, University of Maryland, College Park, College Park, Maryland 20742, USA. mounya@umd.edu
Fritz
Jonathan B
JB
Chi
Tai-Shih
TS
Shamma
Shihab A
SA
D000161:Acoustic Stimulation; D000465:Algorithms; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D004567:Electrodes, Implanted; D005289:Ferrets; D009043:Motor Activity / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D012146:Rest / Q000502:physiology; D013647:Task Performance and Analysis