title: Prospective examination of the efficacy of 2 topical over-the-counter cosmeceutical creams for rapid treatment of facial rhytids.
abstract: OBJECTIVE
  To examine the efficacy of 2 over-the-counter cosmeceutical creams in reducing facial rhytids-Freeze 24/7 Anti-Wrinkle Cream (Freeze 24/7 International LLC, New York, New York) and LiftFusion Micro-Injected M-Tox Transdermal Face Lift (Fusionbeauty, Inc, Boca Raton, Florida)-against placebo (Nutraderm Therapeutic Lotion; Healthpoint, Inc, San Antonio, Texas).
  
  
  METHODS
  A prospective, blinded clinical trial was performed on 42 subjects, comparing 2 cosmeceutical creams that each represent a class of purported rapid rhytid reduction formulas with placebo. Independent analysis by 2 facial plastic surgeons was performed as well as completion of self-assessment questionnaires by the participants.
  
  
  RESULTS
  No complications occurred. Self-evaluation of cream effectiveness was no different for test creams compared with placebo. Neither cream produced substantial reduction of rhytids when examined critically by 2 independent facial plastic surgeons. Stratification by Glogau (photoaging) class did not reveal increased effectiveness based on rhytid severity.
  
  
  CONCLUSIONS
  Two typical over-the-counter rhytid reduction products are ineffective at substantially reducing facial rhytids.
authors: Division of Facial Plastic and Reconstructive Surgery, 801 Welch Rd, Stanford, CA 94305, USA. smost@ohns.stanford.edu
authors: Sam P
authors: SP
authors: Most
mesh_terms: D000287:Administration, Topical; D004311:Double-Blind Method; D005145:Face; D006801:Humans; D004366:Nonprescription Drugs / Q000494:pharmacology*; D011446:Prospective Studies; D015595:Skin Aging / Q000187:drug effects*; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004366:Nonprescription Drugs