Trypanocidal tetrahydrofuran lignans from Peperomia blanda.
Five tetrahydrofuran lignans and two known flavones were isolated from the aerial parts of Peperomia blanda. The structures of the isolated lignans were elucidated by interpretation of their spectroscopic data, including by gHMQC and gHMBC. The relative and absolute configurations of the isolates were determined from NOESY interactions and optical properties, respectively. Four of the lignans were diastereomeric whilst one was of mixed biosynthetic origin. All but one of the lignans exhibited high in vitro trypanocidal activity when assayed against epimastigotes of Trypanosoma cruzi strain Y.
Felippe
Lidiane Gaspareto
LG
Instituto de Química, Universidade Estadual Paulista, CP 355, 14800-900 Araraquara, SP, Brazil.
Baldoqui
Debora Cristina
DC
Kato
Massuo Jorge
MJ
Bolzani
Vanderlan da Silva
Vda S
Guimarães
Elsie Franklin
EF
Cicarelli
Regina Maria Barreto
RM
Furlan
Maysa
M
D000818:Animals; D005663:Furans / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D036941:Peperomia / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects
D005663:Furans; D017705:Lignans; D014344:Trypanocidal Agents; C018674:tetrahydrofuran