Acute-myeloid-leukemia-targeted toxins kill tumor cells by cell-type-specific mechanisms and synergize with TRAIL to allow manipulation of the extent and mechanism of tumor cell death.
Horita
H
H
Frankel
A E
AE
Thorburn
A
A
D000208:Acute Disease; D000590:Amino Acid Chloromethyl Ketones / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D001549:Benzamides / Q000037:antagonists & inhibitors; D020169:Caspases / Q000502:physiology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D004167:Diphtheria Toxin / Q000494:pharmacology* / Q000633:toxicity; D016503:Drug Delivery Systems; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D007377:Interleukin-3 / Q000494:pharmacology* / Q000633:toxicity; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000473:pathology; D009363:Neoplasm Proteins / Q000187:drug effects / Q000502:physiology; D011725:Pyridines / Q000037:antagonists & inhibitors; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000187:drug effects; D016185:Receptors, Interleukin-3 / Q000187:drug effects; D011993:Recombinant Fusion Proteins / Q000494:pharmacology* / Q000633:toxicity; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000494:pharmacology; D020298:U937 Cells / Q000187:drug effects
D000590:Amino Acid Chloromethyl Ketones; D000970:Antineoplastic Agents; D001549:Benzamides; D004167:Diphtheria Toxin; D007377:Interleukin-3; D009363:Neoplasm Proteins; D011725:Pyridines; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D016185:Receptors, Interleukin-3; D011993:Recombinant Fusion Proteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C096713:benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; C527526:diphtheria toxin-GMCSF fusino protein, recombinant; C407154:diphtheria toxin-interleukin-3 fusion protein, recombinant; C118739:entinostat; D020169:Caspases