title: Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials.
abstract: We have previously reported that an osteopontin-derived SVVYGLR peptide exhibited potent angiogenic activity in vitro and in vivo. In the present study, the focus points were on the in vitro effect of SVVYGLR on bone marrow stromal cell proliferation, as well as its in vivo effect on bone tissue formation when grafts made of CO3Ap-collagen sponge- as a scaffold biomaterial containing the SVVYGLR motif - were implanted. SVVYGLR peptide promoted bone marrow stromal cell proliferation. When a CO3Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells - as well as prominent angiogenesis - inside the graft could be detected after one week. These results thus suggested that our scaffold biomaterials including the peptide could be useful for bone tissue regeneration.
authors: Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science, Osaka 565-0871, Japan. y-hamada@dent.osaka-u.ac.jp
authors: Yoshinosuke
authors: Y
authors: Hamada
authors: Hiroshi
authors: H
authors: Egusa
authors: Yoshitosi
authors: Y
authors: Kaneda
authors: Isao
authors: I
authors: Hirata
authors: Naomasa
authors: N
authors: Kawaguchi
authors: Takafumi
authors: T
authors: Hirao
authors: Takuya
authors: T
authors: Matsumoto
authors: Makiko
authors: M
authors: Yao
authors: Kiyoshi
authors: K
authors: Daito
authors: Mayuka
authors: M
authors: Suzuki
authors: Hirofumi
authors: H
authors: Yatani
authors: Michiharu
authors: M
authors: Daito
authors: Masayuki
authors: M
authors: Okazaki
authors: Nariaki
authors: N
authors: Matsuura
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000098:blood supply / Q000187:drug effects*; D001861:Bone Regeneration / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D008297:Male; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D053495:Osteopontin / Q000737:chemistry*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017154:Stromal Cells / Q000187:drug effects
chemical_list: D043925:Angiogenesis Inducing Agents; D010446:Peptide Fragments; D053495:Osteopontin