title: The luminance-response function of the human photopic electroretinogram: a mathematical model.
abstract: The luminance-response function of the brief flash full-field photopic electroretinogram (ERG) rises to a peak before falling to a sub-maximal plateau -- the 'photopic hill'. The combination of on- and off-responses inherent in the brief flash photopic ERG suggests that this luminance-response function could be modelled by the sum of a Gaussian function and a logistic growth function. Photopic ERGs to a luminance series of brief flashes against three different background luminances recorded from seven healthy adults showed the characteristic 'photopic hill' function for b-wave amplitudes which were satisfactorily fitted with the sum of a Gaussian curve and a logistic growth curve. As background luminance increased, both components shifted to the right on the luminance axis. The Gaussian component increased in amplitude while the logistic growth function component decreased in amplitude. The luminance-response function of a complete congenital stationary night blindness patient had almost no logistic growth component.
authors: Department of Clinical Physics, Yorkhill NHS Trust and University of Glasgow, Glasgow, UK. r.hamilton@clinmed.gla.ac.uk
authors: R
authors: R
authors: Hamilton
authors: M A
authors: MA
authors: Bees
authors: C A
authors: CA
authors: Chaplin
authors: D L
authors: DL
authors: McCulloch
mesh_terms: D000221:Adaptation, Ocular / Q000502:physiology; D000293:Adolescent; D000328:Adult; D004596:Electroretinography / Q000379:methods*; D006801:Humans; D008027:Light; D016015:Logistic Models; D008433:Mathematics; D008875:Middle Aged; D008954:Models, Biological; D009755:Night Blindness / Q000151:congenital / Q000503:physiopathology; D016011:Normal Distribution; D010775:Photic Stimulation / Q000379:methods; D011446:Prospective Studies