Pericytes: gatekeepers in tumour cell metastasis?
Tumour cells use two major routes to spread during metastasis, e.g. lymph vessels and blood vessels within or surrounding the primary tumour. The growth rate of the primary tumour often correlates with the quantity of new blood vessels that form within the tumour. However, qualitative abnormalities of the tumour vasculature profoundly affect the perfusion of the primary tumour and the escape of tumour cells into the circulation. In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis.
Gerhardt
Holger
H
Vascular Biology Laboratory, London Research Institute-Cancer Research UK, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK. holger.gerhardt@cancer.org.uk
Semb
Henrik
H
D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000077214:Becaplermin; D002448:Cell Adhesion; D002465:Cell Movement; D042783:Endothelial Cells / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D009360:Neoplastic Cells, Circulating / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism* / Q000517:prevention & control; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D020286:Pericytes / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D020574:Proto-Oncogene Proteins c-sis; D015398:Signal Transduction / Q000187:drug effects; D017154:Stromal Cells / Q000378:metabolism
D020533:Angiogenesis Inhibitors; D019006:Neural Cell Adhesion Molecules; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin