title: Nematicidal prenylated flavanones from Phyllanthus niruri.
abstract: Two prenylated flavanones have been isolated from the hexane extract of Phyllanthus niruri plant. The structure of these flavanones were established as 8-(3-Methyl-but-2-enyl)-2-phenyl chroman-4-one (1) and 2-(4-hydroxyphenyl)-8-(3-methyl-but-2-enyl)-chroman-4-one (2) on the basis of spectral analysis. These were evaluated for nematicidal activity against root-knot, Meloidogyne incognita, and reniform, Rotylenchulus reniformis, nematodes. Compound 2 exhibited nematicidal activity at par with the standard carbofuran (LC50 3.3 and 3.1ppm, respectively) when tested against reniform nematode. The LC50 value against root-knot nematode was found to be 14.5ppm. Compound 1 however, showed moderate activity against both the test nematodes.
authors: Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi 110 012, India. iamshakil@gmail.com
authors: N A
authors: NA
authors: Shakil
authors: Pankaj
authors: J
authors: J
authors: Kumar
authors: R K
authors: RK
authors: Pandey
authors: D B
authors: DB
authors: Saxena
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002839:Chromans / Q000737:chemistry* / Q000302:isolation & purification; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D009348:Nematoda / Q000737:chemistry / Q000187:drug effects*; D029803:Phyllanthus / Q000737:chemistry*; D018517:Plant Roots / Q000187:drug effects / Q000254:growth & development / Q000469:parasitology*; D013045:Species Specificity; D013237:Stereoisomerism
chemical_list: C530096:2-(4-hydroxyphenyl)-8-(3-methyl-but-2-enyl)-chroman-4-one; C530097:8-(3-methyl-but-2-enyl)-2-phenyl chroman-4-one; D000969:Antinematodal Agents; D002839:Chromans; D044950:Flavanones