title: Laser scanning tomography measurement of the extent of papilledema in the follow-up examination of patients with idiopathic intracranial hypertension.
abstract: OBJECTIVE
  The authors evaluated the characteristics of patients with idiopathic intracranial hypertension (IIH), and compared laser scanning tomography (LST) measurements of papilledema with the clinical parameters and cerebrospinal fluid (CSF) opening pressures obtained.
  
  
  METHODS
  Twenty-four patients were included in this study; these individuals included 21 women and three men with a mean age of 35.5 +/- 9.7 years and a mean body mass index (BMI) of 35.4 +/- 8.3 kg/m2. The authors conducted a prospective follow-up study over a period of 12 months through a series of four consultations with each patient. These patients had a mean time to treatment of 6.2 +/- 7.9 months and, at the time of diagnosis, suffered a mean of 2.8 +/- 1.3 symptoms each. Laser scanning tomography of the optic disc revealed a mean global rim volume of 1.693 +/- 1.662 mm3 and a mean height of 0.604 +/- 0.306 mm. The mean CSF opening pressure was 31.3 +/- 6.3 cm H2O.
  
  
  RESULTS
  During the follow-up period, all patients improved significantly with regard to clinical parameters (p < 0.001), BMI reduction (p < 0.001), and reduction of visual field deficits (p = 0.007); visual acuity remained unchanged. In all patients at each successive consultation, the CSF opening pressure was lower than it had been at the previous consultation (p = 0.001). Laser scanning tomography measurements demonstrated a statistically significant reduction in both optic disc parameters over the follow-up period (global rim volume, p = 0.044; mean height, p = 0.019). The CSF opening pressure and the LST measurements correlated significantly with the number of symptoms (CSF opening pressure, p < 0.001; global rim volume, p = 0.001; mean height, p < 0.001). The mean area under the receiver operating characteristic curve in detecting the presence of clinical symptoms was 0.87 for CSF opening pressure, 0.7 for rim volume, and 0.81 for mean optic disc height.
  
  
  CONCLUSIONS
  Laser scanning tomography measurements are useful for evaluating the degree of papilledema in patients with IIH and correspond well with clinical data and measurements of CSF opening pressure. If a diagnosis of IIH is established, LST measurements may replace repeated CSF opening pressure measurements in follow-up monitoring.
authors: Department of Neurology, University-Hospital Erlangen, Germany. josef.heckmann@uk-erlangen.de
authors: Josef G
authors: JG
authors: Heckmann
authors: Florian
authors: F
authors: Faschingbauer
authors: Christoph
authors: C
authors: Lang
authors: Udo
authors: U
authors: Reulbach
authors: Matthias
authors: M
authors: Dütsch
authors: Christian Y
authors: CY
authors: Mardin
authors: Stefan
authors: S
authors: Schwab
mesh_terms: D000328:Adult; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D018613:Microscopy, Confocal / Q000379:methods; D010211:Papilledema / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D019095:Point-of-Care Systems; D011446:Prospective Studies; D011559:Pseudotumor Cerebri / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D012720:Severity of Illness Index; D014054:Tomography