title: [Oral flaxseed oil (Linum usitatissimum) in the treatment for dry-eye Sjögren's syndrome patients].
abstract: OBJECTIVE
  To evaluate if oral flaxseed oil (Linum usitatissimum), which reduces the inflammation in rheumatoid arthritis, may help keratoconjunctivitis sicca's treatment in Sjögren's syndrome patients.
  
  
  METHODS
  In a randomized clinical trial, 38 female patients with rheumatoid arthritis or systemic lupus erithematosus associated with keratoconjunctivitis sicca and Sjögren's syndrome were consecutively selected from patients of the Department of Rheumatology of the Amazonas University Hospital. Keratoconjunctivitis sicca diagnosis was based on a dry-eye symptom survey score (Ocular Surface Disease Index - OSDI), Schirmer-I test, fluorescein break-up time, 1% Rose Bengal staining of ocular surface measured by the van Bijsterveld scale. All patients had ocular surface inflammation evaluated and quantified by conjunctival impression cytology, before and after the study. The subjects were divided into three groups with 13 (Group I), 12 (Group II) and 13 (Group III) patients. Group I received flaxseed oil capsules with a final 1 g/day dosis, Group II flaxseed oil capsules with a final 2 g/day dosis and Group III - controls - placebo, for 180 days.
  
  
  RESULTS
  Comparing the results at the beginning and at the end of the treatment, statistically significant changes (p<0.05) in symptoms (OSDI), ocular surface inflammation quantified by conjunctival impression cytology, Schirmer-I test and fluorescein break-up time occurred in Groups I e II when compared to controls.
  
  
  CONCLUSIONS
  Therapy with oral flaxseed oil capsules 1 or 2 g/day reduces ocular surface inflammation and ameliorates the symptoms of keratoconjunctivitis sicca in Sjögren's syndrome patients. Long-term studies are needed to confirm the role of this therapy for keratoconjunctivitis sicca in Sjögren's syndrome.
authors: Universidade de Brasília, Brasília, DF, Brasil. mneuzimar@interlins.com.br
authors: Manuel Neuzimar
authors: MN
authors: Pinheiro
authors: Procópio Miguel
authors: PM
authors: dos Santos
authors: Regina Cândido Ribeiro
authors: RC
authors: dos Santos
authors: Jeison de Nadai
authors: Jde N
authors: Barros
authors: Luiz Fernando
authors: LF
authors: Passos
authors: José
authors: J
authors: Cardoso Neto
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D003941:Diagnostic Techniques, Ophthalmological; D004812:Epidemiologic Methods; D005260:Female; D019793:Fluorescein; D006801:Humans; D007638:Keratoconjunctivitis Sicca / Q000175:diagnosis / Q000188:drug therapy*; D008043:Linseed Oil / Q000008:administration & dosage / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged; D010919:Placebos; D012395:Rose Bengal; D012859:Sjogren's Syndrome / Q000150:complications*; D013666:Tears / Q000502:physiology
chemical_list: D010919:Placebos; D012395:Rose Bengal; D008043:Linseed Oil; D019793:Fluorescein