Direct process integration of extraction and expanded bed adsorption in the recovery of crocetin derivatives from Fructus Gardenia.
A process that integrated an extraction tank (EXT) and an expanded bed adsorption (EBA) into a new system EXT-EBA for direct purifying crocetin derivatives from Fructus Gardenia was described. Conditions were set to allow the extraction and purification in a single step. A comparison between the integrated process and the conventional process to purify crocetin derivatives was presented. The integrated process resulted in 52.79% recovery of crocin compared to 24.12% in the conventional process. The process time and solvent used were decreased in the integrated process. The result suggests that the EXT-EBA integrates extraction, clarification, and purification in a single step, greatly simplifying the process flow and reducing the cost and time of extraction and purification of crocetin derivatives from Fructus Gardenia.
Zhang
Min
M
Modern Engineering Center for Traditional Chinese Medicine, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. zhangm@mail.ecust.edu.cn
Hu
Ping
P
Liang
Qionglin
Q
Yang
Huihua
H
Liu
Qingfei
Q
Wang
Yiming
Y
Luo
Guoan
G
D000327:Adsorption; D002338:Carotenoids / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D002845:Chromatography / Q000295:instrumentation / Q000379:methods*; D032062:Gardenia / Q000737:chemistry*; D015394:Molecular Structure; D015203:Reproducibility of Results; D014801:Vitamin A / Q000031:analogs & derivatives
C487773:trans-sodium crocetinate; D014801:Vitamin A; D002338:Carotenoids