Measuring metals with RNA.
In a recent issue of Cell, Winkler and coworkers (Dann et al., 2007) describe in atomic detail the structural changes that allow a specific RNA aptamer (the M box) to regulate transcription in response to changing cellular magnesium levels.
Helmann
John D
JD
Department of Microbiology, Cornell University, Wing Hall, Ithaca, NY 14853-8101, USA. jdh9@cornell.edu
D000494:Allosteric Regulation; D052157:Aptamers, Nucleotide / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*
D052157:Aptamers, Nucleotide; D008670:Metals; D012313:RNA