Muscle strength is a marker of insulin resistance in patients with type 2 diabetes: a pilot study.
To examine the effect of muscle strength on insulin resistance, we investigated the association between quantitative lower-extremity muscle strength and insulin resistance index as evaluated by homeostasis model assessment (HOMA-IR) in patients with type 2 diabetes (20 men and 20 women, mean age SD: 53.3 12.7 years). By simple linear regression analyses, the knee extension force normalized for body weight (%KEF) was found to be significantly correlated with HOMA-IR in both male (r = -0.510, P<0.05) and female patients (r = -0.462, P<0.05). Stepwise regression analysis also showed that %KEF was an independent determinant of HOMA-IR (beta = -0.331, F = 5.400, P<0.005), as was BMI (beta = 0.409, F = 8.260, P<0.05). Our data suggest that lower-extremity muscle strength is independently associated with insulin resistance, which seems to be consistent with previous reports that resistance training improves glycemic control in type 2 diabetic patients. Further studies based on a larger study population will be required to confirm this possibility.
Nomura
Takuo
T
Department of Physical Therapy, School of Comprehensive Rehabilitation, Osaka Prefecture University, Habikino, Japan.
Ikeda
Yukio
Y
Nakao
Satoshi
S
Ito
Kenichi
K
Ishida
Kenji
K
Suehiro
Tadashi
T
Hashimoto
Kozo
K
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D007717:Knee / Q000502:physiology; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D010865:Pilot Projects
D015415:Biomarkers