title: Tolerance of ruminant animals to high dose in-feed administration of a selenium-enriched yeast.
abstract: The objective of the study was to determine if there were adverse effects on animal health and performance when a range of ruminant animal species were fed at least 10 times the maximum permitted European Union (EU) Se dietary inclusion rate (0.568 mg of Se/kg of DM) in the form of Se-enriched yeast (SY) derived from a specific strain of Saccharomyces cerevisiae, CNCM I-3060. In a series of studies, dairy cows, beef cattle, calves, and lambs were offered a control diet that contained no Se supplement or a treatment diet that contained the same basal feed ingredients plus a SY supplement that increased total dietary Se from 0.15 to 6.25, 0.20 to 6.74, 0.15 to 5.86, and 0.14 to 6.63 mg of Se/kg of DM, respectively. The inclusion of the SY supplement increased (P < 0.001) whole-blood Se concentrations, reaching maximum mean values of 716, 1,505, 1,377, and 724 ng of Se/mL for dairy cattle, beef cattle, calves, and lambs, respectively. Seleno-methionine accounted for 10% of total whole-blood Se in control animals, whereas the proportion in SY animals ranged between 40 and 75%. Glutathione peroxidase (EC 1.11.1.9) activity was greater (P < 0.05) in SY animals compared with controls. A range of other biochemical and hematological parameters were assessed, but few differences of biological significance were established between treatment groups. There were no differences between treatment groups within each species with regard to animal physical performance or overall animal health. It was concluded that there were no adverse effects on animal health, performance, and voluntary feed intake with the administration of at least 10 times the EU maximum, or approximately 20 times the US Food and Drug Administration permitted concentration of dietary Se in the form of SY derived from a specific strain of Saccharomyces cerevisiae CNCM I-3060.
authors: Animal Science Research Group, School of Agriculture, Policy and Development University of Reading, Earley Gate, Reading RG6 6AR, UK. d.t.juniper@reading.ac.uk
authors: D T
authors: DT
authors: Juniper
authors: R H
authors: RH
authors: Phipps
authors: D I
authors: DI
authors: Givens
authors: A K
authors: AK
authors: Jones
authors: C
authors: C
authors: Green
authors: G
authors: G
authors: Bertin
mesh_terms: D000821:Animal Feed / Q000009:adverse effects* / Q000032:analysis; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002417:Cattle / Q000097:blood / Q000254:growth & development* / Q000378:metabolism*; D004032:Diet / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D007774:Lactation / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000378:metabolism*; D012643:Selenium / Q000009:adverse effects* / Q000097:blood / Q000737:chemistry; D012756:Sheep / Q000097:blood / Q000254:growth & development* / Q000378:metabolism*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D012643:Selenium