title: Protocol biopsy: today's fine-needle aspiration biopsy?
abstract: This counter view of protocol biopsy suggests that the widespread clinical use of this technique may be questionable. It may remain primarily a valuable research tool. Cost and risk remain as major issues. Be it screening by routine computed tomography scan for apparently normal people or routine biopsy of normal functioning kidneys there is always the risk that more harm than good might be done. The proof of benefit should be strong (scientifically strong), which requires confirmation and reproducibility of controlled trials. Patients need to know how protocol biopsy is to be used (research, management or both) and the strength of the scientific evidence concerning benefit in long-term management.
authors: University of Alabama Medical Center, Birmingham, AL 35216, USA. jjcurtis@uab.edu
authors: John J
authors: JJ
authors: Curtis
mesh_terms: D044963:Biopsy, Fine-Needle / Q000941:ethics* / Q000379:methods*; D006084:Graft Rejection / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D016030:Kidney Transplantation / Q000473:pathology*