Supernumerary ring chromosomes accompanied with near-tetraploidy following chemotherapy and cranial radiation in a girl with a relapsed acute lymphoblastic leukemia.
Supernumerary ring chromosomes of different sizes and near-tetraploidy were presented in the bone marrow cells of 12-year-old girl with relapsed acute lymphoblastic leukemia who had been treated previously with chemotherapy and cranial radiation. Despite significant chromosomal abnormalities, complete hematologic and cytogenetic remissions were achieved.
Gindina
Tatyana
T
Medical Center of Surgut, The Laboratory of Medical Genetics, 628412, Surgut, Tyumenskaya Region, Russia.
Kondakova
Elena
E
Mamaev
Nikolai
N
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001921:Brain / Q000528:radiation effects; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D011003:Ploidies; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects; D012074:Remission Induction; D012303:Ring Chromosomes
D000970:Antineoplastic Agents