Transcript profile and localization of Wnt signaling-related molecules in human endometrium.
The mRNAs encoding several Wnt ligands, Frizzled receptors, and Wnt antagonists were detected in human endometrium, including SFRP1; the levels of SFRP1 mRNA were higher in the proliferative phase of the menstrual cycle and increased in endometriotic tissue compared with control eutopic endometrium, and they were detected in both glandular and stromal cells but were more abundant in the stroma. Our results suggest that Wnt signaling could function in normal endometrial physiology and the the Wnt signalling inhibitor SFRP1 might play a role in endometrial growth and endometriosis development.
Cheng
Ching-Wen
CW
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK. cwc28@cam.ac.uk
Smith
Stephen K
SK
Charnock-Jones
D Stephen
DS
D000328:Adult; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000737:chemistry* / Q000473:pathology; D004739:England; D005260:Female; D051157:Frizzled Receptors / Q000235:genetics; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D008597:Menstrual Cycle / Q000235:genetics; D008875:Middle Aged; D009520:New Zealand; D012333:RNA, Messenger / Q000032:analysis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000235:genetics*; D051153:Wnt Proteins / Q000235:genetics*; D000094742:Secreted Frizzled-Related Proteins
D051157:Frizzled Receptors; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger; D051153:Wnt Proteins; C117636:SFRP1 protein, human; D000094742:Secreted Frizzled-Related Proteins