Genetic variants of complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population.
BACKGROUND
The complement factor H (CFH) gene has been recently confirmed to play an essential role in the development of age-related macular degeneration (AMD). There are conflicting reports of its role in coronary heart disease. This study was designed to investigate if, using a family-based approach, there was an association between genetic variants of the CFH gene and risk of early-onset coronary heart disease.


METHODS
We evaluated 6 SNPs and 5 common haplotypes in the CFH gene amongst 1494 individuals in 580 Irish families with at least one member prematurely affected with coronary heart disease. Genotypes were determined by multiplex SNaPshot technology.


RESULTS
Using the TDT/S-TDT test, we did not find an association between any of the individual SNPs or any of the 5 haplotypes and early-onset coronary heart disease.


CONCLUSIONS
In this family-based study, we found no association between the CFH gene and early-onset coronary heart disease.
Meng
Weihua
W
Centre for Clinical and Population Sciences, Queen's University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland, UK. wmeng01@qub.ac.uk
Hughes
Anne
A
Patterson
Chris C
CC
Belton
Christine
C
Kamaruddin
Muhammad S
MS
Horan
Paul G
PG
Kee
Frank
F
McKeown
Pascal P
PP
D017668:Age of Onset; D000704:Analysis of Variance; D017242:Complement Factor H / Q000235:genetics; D003327:Coronary Disease / Q000453:epidemiology / Q000235:genetics*; D005819:Genetic Markers; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009660:Northern Ireland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
C493495:CFH protein, human; D005819:Genetic Markers; D017242:Complement Factor H