title: Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study.
abstract: Common polymorphisms in the CRP gene are associated with plasma CRP levels in population-based studies, but associations with age-related events are uncertain. A previous study of CRP haplotypes in older adults was broadened to include longevity and cause-specific mortality (all-cause, noncardiovascular (non-CV), and cardiovascular (CV)). Common haplotypes were inferred from four tagSNPs in 4512 whites and five tagSNPs in 812 blacks from the Cardiovascular Health Study, a longitudinal cohort of adults over age 65. Exploratory analyses addressed early versus late mortality. CRP haplotypes were not associated with all-cause mortality or longevity overall in either population, but associations with all-cause mortality differed during early and late periods. In blacks, the haplotype tagged by 3872A (rs1205) was associated with increased risk of non-CV mortality, relative to other haplotypes (adjusted hazard ratio for each additional copy: 1.42, 95% CI: 1.07, 1.87). Relative to other haplotypes, this haplotype was associated with decreased risk of early but not decreased risk of late CV mortality in blacks; among whites, a haplotype tagged by 2667C (rs1800947) gave similar but nonsignificant findings. If confirmed, CRP genetic variants may be weakly associated with CV and non-CV mortality in older adults, particularly in self-identified blacks.
authors: Department of Epidemiology, University of Washington, Seattle, WA, United States. lah@u.washington.edu
authors: Lucia A
authors: LA
authors: Hindorff
authors: Kenneth M
authors: KM
authors: Rice
authors: Leslie A
authors: LA
authors: Lange
authors: Paula
authors: P
authors: Diehr
authors: Indrani
authors: I
authors: Halder
authors: Jeremy
authors: J
authors: Walston
authors: Pui
authors: P
authors: Kwok
authors: Elad
authors: E
authors: Ziv
authors: Caroline
authors: C
authors: Nievergelt
authors: Steven R
authors: SR
authors: Cummings
authors: Anne B
authors: AB
authors: Newman
authors: Russell P
authors: RP
authors: Tracy
authors: Bruce M
authors: BM
authors: Psaty
authors: Alexander P
authors: AP
authors: Reiner
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000368:Aged; D002097:C-Reactive Protein / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000208:ethnology / Q000235:genetics / Q000401:mortality; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D016014:Linear Models; D008136:Longevity / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016016:Proportional Hazards Models; D014481:United States
chemical_list: D002097:C-Reactive Protein