title: Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient.
abstract: We report a case of Neocosmospora vasinfecta keratitis in a 55-year-old man. While the patient did not recall any specific trauma or eye injury, he might have sustained a trivial wound during the course of his duties as a farmer. Direct examination of corneal scrapings revealed fungus filaments. As topical treatment with natamycin and econazole and subsequent systemic ketoconazole therapy failed, a full thickness therapeutic keratoplasty was performed. Post-operative treatment with amphotericin B and clotrimazole combined with cyclosporine resulted in a complete cure. The residual corneal infiltration in the recipient cornea became clear in a week. The fungal isolate was initially identified as a Fusarium species, but later reidentified through the use of morphological characteristics and sequence analysis of the internal transcribed spacer region as N. vasinfecta. The latters is a Hypocrealean fungus not hitherto reported as a causative agent of keratomycosis.
authors: Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, India. micro@cbe.aravind.org
authors: P
authors: P
authors: Manikandan
authors: H F
authors: HF
authors: Vismer
authors: L
authors: L
authors: Kredics
authors: I
authors: I
authors: Dóczi
authors: W F O
authors: WF
authors: Marasas
authors: M
authors: M
authors: Bhaskar
authors: R
authors: R
authors: Anita
authors: R
authors: R
authors: Revathi
authors: V
authors: V
authors: Narendran
mesh_terms: D001228:Aspergillosis / Q000382:microbiology* / Q000628:therapy; D003320:Corneal Ulcer / Q000382:microbiology* / Q000628:therapy; D004271:DNA, Fungal / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D015821:Eye Infections, Fungal / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D006999:Hypocreales / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged
chemical_list: D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer