Renal cell carcinoma associated with TFE3 gene fusion in an elderly woman.
We present a case report of a renal cell carcinoma with TFE3 overexpression (related to TFE3 gene fusion) in a 63-year-old woman. Such tumors have been reported predominantly in children and young adults, and to our knowledge there are only 2 such cases mentioned in the literature in patients older than ours. However, we believe that this tumor may be underdiagnosed in adults owing to its similarity to clear cell (conventional) carcinoma and in some cases to papillary renal carcinoma.
LaGrange
Chad A
CA
University of Kentucky, Department of Surgery, Division of Urology and Pathology, Lexington, Kentucky 40536, USA. Calagr2@email.uky.edu
Lele
Subodh M
SM
Strup
Stephen E
SE
D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000032:analysis / Q000235:genetics*; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000175:diagnosis / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D033162:Incidental Findings; D047908:Intracellular Signaling Peptides and Proteins; D007680:Kidney Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000235:genetics*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000032:analysis / Q000235:genetics*; D014178:Translocation, Genetic; D014746:Vimentin / Q000032:analysis
C422743:ASPSCR1 protein, human; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; C069203:TFE3 protein, human; D014746:Vimentin