meta-PPISP: a meta web server for protein-protein interaction site prediction.
A number of complementary methods have been developed for predicting protein-protein interaction sites. We sought to increase prediction robustness and accuracy by combining results from different predictors, and report here a meta web server, meta-PPISP, that is built on three individual web servers: cons-PPISP (http://pipe.scs.fsu.edu/ppisp.html), Promate (http://bioportal.weizmann.ac.il/promate), and PINUP (http://sparks.informatics.iupui.edu/PINUP/). A linear regression method, using the raw scores of the three servers as input, was trained on a set of 35 nonhomologous proteins. Cross validation showed that meta-PPISP outperforms all the three individual servers. At coverages identical to those of the individual methods, the accuracy of meta-PPISP is higher by 4.8 to 18.2 percentage points. Similar improvements in accuracy are also seen on CAPRI and other targets.


BACKGROUND
meta-PPISP can be accessed at http://pipe.scs.fsu.edu/meta-ppisp.html
Qin
Sanbo
S
Institute of Molecular Biophysics, School of Computational Science, Florida State University, Tallahassee, Florida 32306, USA.
Zhou
Huan-Xiang
HX
D000465:Algorithms; D000595:Amino Acid Sequence; D001665:Binding Sites; D020407:Internet; D008969:Molecular Sequence Data; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000737:chemistry*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software
D011506:Proteins