Association of genetic markers within the BMP15 gene with anovulation and infertility in women with polycystic ovary syndrome.
We analyzed two polymorphisms (-9C>G and IVS1+905A>G) within the BMP15 gene in women from Spain with polycystic ovary syndrome (PCOS). In this study, the BMP15 gene does not seem to be associated with PCOS. Nonetheless, we observed in both markers a genetic association with anovulation or infertility in these patients.
Gónzalez
Alejandro
A
Unidad de Reproducción y Genética Humana, Centro Avanzado de Fertilidad, Jerez de la Frontera, Spain.
Ramírez-Lorca
Reposo
R
Calatayud
Carmen
C
Mendoza
Nicolás
N
Ruiz
Agustín
A
Sáez
Maria Eugenia
ME
Morón
Francisco Jesús
FJ
D000858:Anovulation / Q000235:genetics*; D055430:Bone Morphogenetic Protein 15; D005260:Female; D005819:Genetic Markers / Q000502:physiology*; D055429:Growth Differentiation Factor 9; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
C525901:BMP15 protein, human; D055430:Bone Morphogenetic Protein 15; C525897:GDF9 protein, human; D005819:Genetic Markers; D055429:Growth Differentiation Factor 9; D036341:Intercellular Signaling Peptides and Proteins