A preliminary study of the effects of an extract of Ligularia fischeri leaves on type II collagen-induced arthritis in DBA/1J mice.
The present study was undertaken to determine whether Ligularia fischeri leaf extract (LF) is efficacious against collagen-induced arthritis (CIA) in mice. DBA/1J mice were immunized with bovine type II collagen and treated with LF (100 and 200 mg/kg) for 49 days. Mice were assessed regularly for signs of arthritis and the levels of rheumatoid factor, anti-type II collagen antibody, cytokines, AST, ALT, and creatinine in serum were also examined after the animals were killed. The arthritis score and paw edema were markedly suppressed in the groups treated with LF. Moreover, levels of rheumatoid factor, anti-type II collagen antibody, tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 in sera were reduced by LF administration. These data suggest that L. fischeri might be effective for the treatment of inflammatory arthritis like human rheumatoid arthritis.
Choi
Eun Mi
EM
College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
Kim
Young Ho
YH
D000704:Analysis of Variance; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020552:Comet Assay; D003603:Cytotoxins / Q000633:toxicity*; D004249:DNA Damage; D005285:Fermentation; D005399:Fishes; D005502:Food / Q000633:toxicity*; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis; D005520:Food Preservatives / Q000032:analysis / Q000633:toxicity; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008296:Malaysia; D019216:Metals, Heavy / Q000032:analysis / Q000633:toxicity; D009153:Mutagens / Q000633:toxicity*; D017747:Seafood / Q000032:analysis / Q000633:toxicity*; D013778:Tetrazolium Salts; D013844:Thiazoles
D003603:Cytotoxins; D005520:Food Preservatives; D019216:Metals, Heavy; D009153:Mutagens; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue