title: Association of various sperm parameters with unexplained repeated early pregnancy loss--which is most important?
abstract: OBJECTIVE
  To study the relationship of various sperm characteristics with repeated unexplained early pregnancy loss.
  
  
  METHODS
  Semen samples from husbands of 74 couples with the history of repeated early pregnancy loss were analyzed as per WHO criteria, and DNA integrity was studied in each case by Acridine Orange staining test. Semen samples from 65 husbands of proven fertility were also studied for comparison.
  
  
  RESULTS
  No statistically significant differences were noted in the age of the husbands, sperm concentration, total count per ejaculate, and rapid progressive motility of sperms between the two groups. On the other hand, significant differences were found in total motile sperms per ejaculate, percentage of motile sperm and, most importantly, in the DNA integrity value.
  
  
  CONCLUSIONS
  The sperm DNA-integrity damage is an important paternal factor associated with repeated embryonic or early fetal loss and should be included in the evaluation of these couples.
authors: Department of Obstetrics and Gynecology, Vivekananda Institute of Medical Sciences, 99, Sarat Bose Road, Kolkata 700026, India. sudhin@vsnl.net
authors: Sudhindra Mohan
authors: SM
authors: Bhattacharya
mesh_terms: D000026:Abortion, Habitual / Q000503:physiopathology*; D000328:Adult; D004249:DNA Damage; D006801:Humans; D008297:Male; D013081:Sperm Motility; D013094:Spermatozoa / Q000502:physiology*