Chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chernobyl NPP accident--with focus on immunoglobulin heavy chain gene analysis.
Clinical data and immunoglobulin variable heavy chain (IgVH) gene configuration were analyzed in 47 CLL patients, exposed to ionizing radiation (IR) due to Chernobyl NPP accident, and 141 non-exposed patients. Clean-up workers of the second quarter of 1986 (n=19) were picked out as separate group with the highest number of unmutated cases (94.4%), increased usage of IgVH1-69 (33.3%) and IgVH3-21 (16.7%) genes, high frequency of secondary solid tumors (6 cases) and Richter transformation (4 cases). These preliminary data suggest that CLL in the most suffered contingent due to Chernobyl NPP accident might have some specific features.
Abramenko
Iryna
I
Research Centre for Radiation Medicine, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine. nbilous@yahoo.com
Bilous
Nadia
N
Chumak
Anatoliy
A
Davidova
Ekaterina
E
Kryachok
Iryna
I
Martina
Zoya
Z
Nechaev
Stanislav
S
Dyagil
Iryna
I
Bazyka
Dmytriy
D
Bebeshko
Vladimir
V
D000328:Adult; D000368:Aged; D047852:Chernobyl Nuclear Accident; D015331:Cohort Studies; D005260:Female; D015870:Gene Expression; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011839:Radiation, Ionizing; D015996:Survival Rate
D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region