title: The total synthesis of neoamphimedine.
abstract: Neoamphimedine, a pyridoacridine alkaloid from Xestospongia sp., is a potent antitumor agent both in vitro and in vivo. Neoamphimedine can efficiently induce topoisomerase II mediated catenation of plasmid DNA in vitro and is the only member of more than one hundred pyridoacridines thus far to have this mechanism of action. Herein we report the first total synthesis of neoamphimedine.
authors: Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
authors: Daniel V
authors: DV
authors: LaBarbera
authors: Tim S
authors: TS
authors: Bugni
authors: Chris M
authors: CM
authors: Ireland
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000166:Acridines; C474173:neoamphimedine