Liquid chromatography ion trap/time-of-flight mass spectrometric study on the fragmentation of an acetildenafil analogue.
Liquid chromatography ion-trap time-of-flight mass spectrometry was employed to elucidate the fragmentation pathways of an analogue of acetildenafil. Based on the accurate masses of the parent ion, product ions and neutral losses of acetildenafil analogue, its fragmentation pathways were proposed. The information is useful for the on-line structural identification of unknown analogues of acetildenafil found as adulterants in herbal products.
Zou
Peng
P
Oh
Sharon Sze-Yin
SS
Kiang
Kin-Har
KH
Low
Min-Yong
MY
Koh
Hwee-Ling
HL
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D010879:Piperazines / Q000032:analysis*; D011687:Purines / Q000032:analysis; D000068677:Sildenafil Citrate; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D013450:Sulfones / Q000032:analysis*
D004365:Drugs, Chinese Herbal; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate