Stem cell frontiers: science, ethics and regulation.
The isolation of human stem cells and the cloning of "Dolly" in the late 1990s, based on primate and other animal studies in the previous 20 years, created an explosion of interest that continues with daily reports in much of the world's press. The science has progressed steadily but not always smoothly, with promising discoveries in the potency and flexibility of cells derived from embryonic, umbilical cord and adult tissues. The promise of a revolutionary new era in health and medical sciences and systems requires careful scientific method, ethical debate and supportive legal and regulatory frameworks to achieve success. The frontiers of the science are focusing on the regulation of cell lineage choice and the development of designer stem cells for therapeutic cloning; the ethical debate focuses on the special status of the human embryo and the pathways to applications; while legal and regulatory frameworks differ around the world. There is some risk that the promises are overtaking the reality of progress, with the rush for results and premature offering of dubious remedies compromising scientific method and credibility. Stem cells should not be the snake oil of our times, nor should short cuts and short sell promises, fuelled by illusions of fame and fortune, risk the trust of the public in science and medicine.
Hearn
John
J
The University of Sydney. j.hearn@usyd.edu.au
D001315:Australia; D001709:Biotechnology / Q000941:ethics* / Q000331:legislation & jurisprudence*; D033041:Embryo Research / Q000941:ethics* / Q000331:legislation & jurisprudence*; D053595:Embryonic Stem Cells; D004992:Ethics, Medical; D032984:Ethics, Research; D033161:Government Regulation; D006801:Humans; D033581:Stem Cell Transplantation / Q000941:ethics / Q000331:legislation & jurisprudence; D006113:United Kingdom; D014481:United States