A liposome hydrogel with polyvinyl-pyrrolidone iodine in the local treatment of partial-thickness burn wounds.
Local treatment of burn injuries with conventional anti-infective preparations does not provide the moist environment that promotes fast wound healing. In a randomized controlled trial the effects of liposome polyvinyl-pyrrolidone-iodine (PVP-I) hydrogel, a novel formulation of PVP-I in a liposome hydrogel with high water-binding capacity, were investigated in 43 patients with partial-thickness burn wounds in an intraindividual comparison with a conventional silver-sulfadiazine cream. Treatment with liposome PVP-I hydrogel resulted in significantly faster complete healing of the burn wounds compared with silver-sulfadiazine cream (9.9 +/- 4.5 days versus 11.3 +/- 4.9; P < 0.015). The cosmetic result (smoothness, elasticity, appearance) was rated as excellent for 37.0% of study wounds with liposome PVP-I hydrogel compared with 13.0% of wounds treated with silver-sulfadiazine cream. Local tolerability was good; handling and change of dressing were rated as easy. Local treatment with liposome PVP-I hydrogel thus provides fast wound healing with a favorable cosmetic result.
Homann
Heinz-Herbert
HH
Department of Plastic Surgery, Hand Surgery and Burn Unit, University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany. Heinz.Homann@rub.de
Rosbach
Oliver
O
Moll
Wiebke
W
Vogt
Peter Maria
PM
Germann
Guenter
G
Hopp
Michael
M
Langer-Brauburger
Birgit
B
Reimer
Karen
K
Steinau
Hans-Ulrich
HU
D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002056:Burns / Q000188:drug therapy*; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage*; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D011206:Povidone-Iodine / Q000008:administration & dosage* / Q000627:therapeutic use; D012837:Silver Sulfadiazine / Q000627:therapeutic use; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D008081:Liposomes; C525696:Repithel; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011206:Povidone-Iodine; D012837:Silver Sulfadiazine