title: Polymorphonuclear leukocyte function in type-2 diabetes mellitus patients and its correlation with glycaemic control.
abstract: Infection is an important cause of morbidity and mortality in diabetic patients. Chronic hyperglycaemia impairs host defense mechanism such as cell mediated immunity, polymorphonuclear leukocyte (PMNL) function, antibody formation etc. PMNL serves as bodies first line of defense against various infections. The present study was undertaken to establish a correlation between impaired PMNL function, blood glucose levels and its improvement with good glycaemic control with glibenclamide and glimepiride, with special reference to parameters such as respiratory burst and O2(-) and H2O2 production by diabetic neutrophils.
authors: Department of Pharmacology, BPKIHS, Dharan, Nepal. skbnpl@yahoo.co.in
authors: Swapan Kumar
authors: SK
authors: Bhattacharya
authors: Sunita
authors: S
authors: Shastri
authors: Prabha
authors: P
authors: Mahajan
authors: Sri Venkata
authors: SV
authors: Madhu
authors: Ashoke Kumar
authors: AK
authors: Tripathi
authors: Gajendra Prasad
authors: GP
authors: Rauniar
authors: Balbhadra Prasad
authors: BP
authors: Das
authors: Keshab Raj
authors: KR
authors: Paudel
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects; D002908:Chronic Disease; D048909:Diabetes Complications / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology* / Q000517:prevention & control; D005260:Female; D005905:Glyburide / Q000627:therapeutic use; D006442:Glycated Hemoglobin; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D016897:Respiratory Burst; D013453:Sulfonylurea Compounds / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D005905:Glyburide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; C057619:glimepiride