[VDR knockout mice and bone mineralization disorders].
The calciotropic hormone 1alpha, 25-dihydroxyvitamin D(3) [1alpha, 25 (OH)(2)D(3)] regulates many biological actions such as calcium homeostasis, cell differentiation and proliferations. Most of the biological actions of 1alpha, 25 (OH)(2)D(3) are thought to be mediated by the vitamin D receptor (VDR) , which is a member of a nuclear receptor superfamily acting as a ligand-inducible transcription factor. VDR deficient mice (conventional-VDRKO mice) appear the typical phenotype of vitamin D dependent type II rickets. However, no defect in conventional-VDRKO mice was observed in osteoblast specific-conditional VDRKO mice. Here, we introduce VDR function in bone involving such difference phenotype in these mice.
Takeyama
Ken-ichi
K
University of Tokyo, Institute of Molecular and Cellular Biosciences.
Yamamoto
Yoko
Y
Kato
Shigeaki
S
D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology*; D002113:Calcification, Physiologic; D051379:Mice; D018345:Mice, Knockout; D018167:Receptors, Calcitriol / Q000235:genetics / Q000502:physiology*
D018167:Receptors, Calcitriol