title: The influence of drug morphology on aerosolisation efficiency of dry powder inhaler formulations.
abstract: The physicochemical properties of two forms of spray dried bovine serum albumin (BSA) have been investigated using particle sizing, surface energy measurement, atomic force microscopy (AFM) and colloid probe microscopy. The BSA powder had similar particle size distributions and surface energy but significantly different morphologies and roughness, classified as smooth and corrugated BSA. Adhesion forces between the corrugated BSA and alpha-lactose monohydrate indicated median adhesion forces were significantly less than for smooth/carrier interaction forces. These observations correlated well with aerosolisation from BSA/carrier blends, where the corrugated BSA particles gave a higher fine particle fraction than the smooth BSA, suggesting reduced BSA/carrier adhesion and increased drug liberation. The use of corrugated drug particle morphology in drug carrier DPI systems may lead to improved aerosol performance through reduced drug carrier contact area.
authors: Advanced Drug Delivery Group, University of Sydney, Sydney, NSW 2006, Australia.
authors: Handoko
authors: H
authors: Adi
authors: Daniela
authors: D
authors: Traini
authors: Hak-Kim
authors: HK
authors: Chan
authors: Paul M
authors: PM
authors: Young
mesh_terms: D000336:Aerosols; D002849:Chromatography, Gas; D004337:Drug Carriers / Q000737:chemistry; D007785:Lactose / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D009330:Nebulizers and Vaporizers / Q000592:standards*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D011208:Powders; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000336:Aerosols; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011208:Powders; D012710:Serum Albumin, Bovine; D007785:Lactose