[Prophylactic effect of tropisetron hydrochloride against nausea and vomiting in patients receiving chemotherapy for hematological malignancies].
To establish the effectiveness of oral 5-HT(3) antagonist, oral 5 mg tropisetron was introduced in the 21 cases with hematological malignancies for the prevention of chemotherapy-induced nausea and vomiting. Nausea and vomiting did not develop in 81% of patients receiving the tropisetron in this study. The results suggested that oral tropisetron is effective for the control of acute, and to a lesser extent, delayed, nausea and vomiting. The drug enhanced patients' quality of life and reduced the clinical cost. In conclusion, tropisetron is effective for the prevention of chemotherapy-induced nausea and vomiting in treatment for hematological malignancies. It is suitable as first-line therapy for outpatients.
Nomura
Kenichi
K
Department of Hematology and Oncology, Kyoto Prefectural University of Medical Science Graduate School of Medical Science.
Fujimoto
Yoshiko
Y
Taniguchi
Kyoko
K
Shimizu
Daisuke
D
Okamoto
Masashi
M
Shimura
Kazuho
K
Matsumoto
Yosuke
Y
Kanbayashi
Yuko
Y
Tanaka
Sawako
S
Kaneko
Hiroto
H
Horiike
Shigeo
S
Shimazaki
Chihiro
C
Yokota
Shohei
S
Taniwaki
Masafumi
M
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000008:administration & dosage*; D005260:Female; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D000077526:Tropisetron; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
D000932:Antiemetics; D007211:Indoles; D000077526:Tropisetron