title: Estimating a positive false discovery rate for variable selection in pharmacogenetic studies.
abstract: Selecting predictors to optimize the outcome prediction is an important statistical method. However, it usually ignores the false positives in the selected predictors. In this paper, we develop a positive false discovery rate (pFDR) estimate for a conventional step-wise forward variable selection procedure. We propose two views of a variable selection process, an overall and an individual test. An interesting feature of the overall test is that its power of selecting non-null predictors increases with the proportion of non-null predictors among all candidate predictors. Data analysis is illustrated with a pharmacogenetics example.
authors: Department of Medicine, Division of Biostatistics, Indiana University, Indianapolis, Indiana 46202, USA. lali@inpui.edu
authors: Lang
authors: L
authors: Li
authors: Siu
authors: S
authors: Hui
authors: Gene
authors: G
authors: Pennello
authors: Zeruesenay
authors: Z
authors: Desta
authors: Skaar
authors: S
authors: Todd
authors: Anne
authors: A
authors: Nguyen
authors: David
authors: D
authors: Flockhart
mesh_terms: D000465:Algorithms; D018931:Antineoplastic Agents, Hormonal / Q000493:pharmacokinetics / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D003198:Computer Simulation; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D003627:Data Interpretation, Statistical; D004965:Estrogen Antagonists / Q000493:pharmacokinetics / Q000627:therapeutic use; D005189:False Positive Reactions; D005260:Female; D005544:Forecasting; D005838:Genotype; D006801:Humans; D016014:Linear Models; D009010:Monte Carlo Method; D010597:Pharmacogenetics / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D012107:Research Design; D018401:Sample Size; D013629:Tamoxifen / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D004965:Estrogen Antagonists; D013629:Tamoxifen; D003577:Cytochrome P-450 Enzyme System