An "orphan" finds a home in NSC regulation.
Small molecules that can alter stem cell fate are of immense biological and therapeutic values. In this issue of Chemistry & Biology, Saxe and colleagues report a chemical genetic screen that identified an orphan ligand, P-Ser, which can modulate neural stem/progenitor cell fate.
Ambasudhan
Rajesh
R
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Ding
Sheng
S
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D008024:Ligands; D009474:Neurons / Q000166:cytology*; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects
D008024:Ligands; D010744:Phosphoric Monoester Hydrolases; C022394:phosphoserine phosphatase