A small-molecule antagonist of the hedgehog signaling pathway.
Lee
Jongkook
J
Dept. of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Wu
Xu
X
Pasca di Magliano
Marina
M
Peters
Eric C
EC
Wang
Yan
Y
Hong
Jiyong
J
Hebrok
Metthias
M
Ding
Sheng
S
Cho
Charles Y
CY
Schultz
Peter G
PG
D000426:Alcohol Dehydrogenase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D006574:Heterocyclic Compounds, 2-Ring / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D008156:Luciferases / Q000187:drug effects / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D008819:Mice, Nude; D015394:Molecular Structure; D008970:Molecular Weight; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays; D000071676:Zinc Finger Protein GLI1
C498520:Gli1 protein, mouse; D053823:Hedgehog Proteins; D006574:Heterocyclic Compounds, 2-Ring; C525593:JK184; D051741:Kruppel-Like Transcription Factors; D012333:RNA, Messenger; D013844:Thiazoles; D000071676:Zinc Finger Protein GLI1; C456281:Adh7 protein, mouse; D000426:Alcohol Dehydrogenase; D008156:Luciferases