What can be learned using microarrays?
Whole-genome microarrays identify large numbers of gene expression changes that appear specifically related to disease states such as antineutrophil cytoplasmic autoantibody (ANCA) and systemic lupus erythematosus. Although understanding this enormous volume of esoteric data is difficult, a few basic concepts regarding microarray studies can significantly improve the general reader's comprehension.
Stegall
M D
MD
Department of Surgery, Division of Transplant Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. stegall.mark@mayo.edu
Park
W
W
D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000378:metabolism; D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008181:Lupus Nephritis / Q000235:genetics / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D014657:Vasculitis / Q000235:genetics / Q000378:metabolism