Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents.
Hepatocellular carcinoma, which is one of the most prevalent life-threatening human cancers, is showing an increased incidence worldwide. Recent evidence indicates that the development of hepatocellular carcinoma is associated with not only genetic alterations, but also with profound epigenetic changes. This review summarizes the current knowledge about epigenetic alterations during rodent hepatocarcinogenesis, considers the similarities and differences in epigenetic effects of genotoxic and non-genotoxic rodent liver carcinogens, and discusses the possible role of these effects in the causality of liver tumor development.
Pogribny
Igor P
IP
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. igor.pogribny@fda.hhs.gov
Rusyn
Ivan
I
Beland
Frederick A
FA
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000503:physiopathology; D004249:DNA Damage; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000503:physiopathology; D012377:Rodentia