title: Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study.
abstract: OBJECTIVE
  Angiotensin converting enzyme (ACE) plays major roles in the pathogenesis of cardiovascular diseases (CVD). However, findings on the relations between ACE variants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci (QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases (estimated heritability = 0.58).
  
  
  METHODS
  With 1,271 individuals from 373 young-onset (age <or=40) hypertension pedigrees, 479 deCODE microsatellite markers were genotyped.
  
  
  RESULTS
  We identified a previously unknown loci on chromosomes 9 at 149.4 cM (LOD = 3.00) in addition to a strong linkage peak near the ACE structural locus on chromosome 17 at 89.6 cM (LOD = 4.60).
  
  
  CONCLUSIONS
  These results not only indicate that the ACE gene or nearby loci on 17q was among the strongest QTL influencing ACE activity, but also reveal a potential ACE QTL in human genome, pointing to the complexity of ACE regulation.
authors: Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan, ROC.
authors: Ruey-Yun
authors: RY
authors: Wang
authors: Chia-Min
authors: CM
authors: Chung
authors: Cathy S J
authors: CS
authors: Fann
authors: Hsin-Chou
authors: HC
authors: Yang
authors: Jaw-Wen
authors: JW
authors: Chen
authors: Yuh-Shiun
authors: YS
authors: Jong
authors: Yuh-Shan
authors: YS
authors: Jou
authors: Huey-Ming
authors: HM
authors: Lo
authors: Feng-Ming
authors: FM
authors: Ho
authors: Chih-Sen
authors: CS
authors: Kang
authors: Chien-Chung
authors: CC
authors: Chen
authors: Huan-Cheng
authors: HC
authors: Chang
authors: Song-Kun
authors: SK
authors: Shyue
authors: Wen-Harn
authors: WH
authors: Pan
mesh_terms: D017668:Age of Onset; D002318:Cardiovascular Diseases / Q000201:enzymology; D005260:Female; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D013624:Taiwan
chemical_list: D007703:Peptidyl-Dipeptidase A