title: [Continuous intravenous infusion of midazolam: a clinical study of conscious sedation for dental phobia].
abstract: OBJECTIVE
  To evaluate the sedative effect of continuous intravenous infusion of midazolam in treating severe dental phobia.
  
  
  METHODS
  31 patients with severe dental phobia were enrolled and all of them had good communication with dentists. Two teeth in each patient were assigned to control group and experiment group seperately. The control group received root canal therapy. The experiment group were sedated by intravenous midazolam and received root canal therapy. The treat dependence and behavior therapy efficacy were evaluated. The vital signs and side effects during treatment were noted.
  
  
  RESULTS
  Continuous intravenous infusion of midazolam showed a significant good sedative effect on patients with severe dental phobia. There were statistical difference in the Houpt score and the Frankl score between experiment group and control group (z = -4.846, P = 0.000; z = -4.907, P = 0.000). The total dose of midazolam was (9.58 +/- 3.76) mg, and mean infusion rate was (0.28 +/- 0.06) mg x kg(-1) x h(-1). The blood pressure, heart rate and respiration of experiment group were depressed. But these changes didn't interfere with the completion of the whole treatment. No severe side effects were detected.
  
  
  CONCLUSIONS
  The single use of midazolam as an intravenous sedation agent has satisfactory effect on patients with severe dental phobia.
authors: Painless Dental Treatment Center, Peking Union Medical College Hospital, Beijing 100730, China.
authors: Kuo
authors: K
authors: Wan
authors: Quan
authors: Q
authors: Jing
authors: Ji-zhi
authors: JZ
authors: Zhao
mesh_terms: D001794:Blood Pressure; D016292:Procedural Sedation; D016854:Dental Anxiety; D006339:Heart Rate; D006801:Humans; D006993:Hypnotics and Sedatives; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam