Beta adrenergic receptors in keratinocytes.
Beta2 adrenergic receptors were identified in keratinocytes more than 30 years ago, but their function in the epidermis continues to be elucidated. Abnormalities in their expression, signaling pathway, or in the generation of endogenous catecholamine agonists by keratinocytes have been implicated in the pathogenesis of cutaneous diseases such as atopic dermatitis, vitiligo, and psoriasis. New studies also indicate that the beta2AR also modulates keratinocyte migration, and thus can function to regulate wound reepithelialization. This review focuses on the function of these receptors in keratinocytes and their contribution to cutaneous physiology and disease.
Sivamani
Raja K
RK
Department of Dermatology, University of California, Davis, School of Medicine, Dermatology Research, TB 192, One Shields Avenue, Davis, CA 95616, USA.
Lam
Susanne T
ST
Isseroff
R Rivkah
RR
D002395:Catecholamines / Q000096:biosynthesis; D002465:Cell Movement / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D003876:Dermatitis, Atopic / Q000503:physiopathology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D015603:Keratinocytes / Q000502:physiology*; D011565:Psoriasis / Q000503:physiopathology; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D012871:Skin Diseases / Q000503:physiopathology*; D014820:Vitiligo / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology*
D002395:Catecholamines; D047908:Intracellular Signaling Peptides and Proteins; D018343:Receptors, Adrenergic, beta-2; D000242:Cyclic AMP