[Nodule diagnosed as follicular patterned lesion: are biomarkers the promise?].
There are an increasing number of thyroid nodules found by ultrasound and sampled by fine needle aspiration (FNA). A clinical problem is the accurate distinction between benign and malignant forms of follicular lesion. In this review we discuss the thyroid lesions that are common sources of diagnostic error, and grouped together as follicular patterned lesion, and the molecular markers identified by us and others, and that are able to distinguish the benign from the malignant ones.
Cerutti
Janete M
JM
Departamento de Morfologia, Universidade Federal de São Paulo, SP, Brazil. cerutti-endo@pesquisa.epm.br
D018263:Adenocarcinoma, Follicular / Q000175:diagnosis* / Q000235:genetics; D000236:Adenoma / Q000175:diagnosis* / Q000235:genetics; D018249:Adenoma, Oxyphilic / Q000175:diagnosis / Q000235:genetics; D001120:Arginine / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D000072636:PAX8 Transcription Factor; D047495:PPAR gamma / Q000235:genetics; D051761:Paired Box Transcription Factors; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000235:genetics; D016606:Thyroid Nodule / Q000175:diagnosis* / Q000235:genetics; D051742:Transcription Factor CHOP
D014408:Biomarkers, Tumor; C497249:DDIT3 protein, human; D008565:Membrane Proteins; D000072636:PAX8 Transcription Factor; C083325:PAX8 protein, human; D047495:PPAR gamma; D051761:Paired Box Transcription Factors; D051742:Transcription Factor CHOP; D001120:Arginine