t(6;14)(q15;q32) in a patient with CD5+CD10+ diffuse large B-cell lymphoma.
A 68-year-old man presented with systemic lymph node swelling. A biopsy specimen taken from the right cervical lymph node showed that the normal architecture was replaced by a diffuse proliferation of large lymphoid cells with large atypical nuclei. Immunohistochemical analysis showed that the atypical lymphoid cells were positive for CD5, CD10, CD20, CD79a, and Bcl2, and negative for CD3 and cyclin D1. A diagnosis of diffuse large B-cell lymphoma was made. Karyotypic findings included add(5)(q13), del(6)(q13), add(17)(p11), add(19)(p11), add(19)(p13), and t(6;14)(q15;q32). The serum lactate dehydrogenase level and indirect bilirubin level were slightly elevated. Elliptocytosis was observed in the peripheral blood, and a diagnosis of hereditary spherocytosis was made from the family history. Regarding CD5+CD10+ diffuse large B-cell lymphoma with a non-random chromosomal translocation of t(6;14)(q15;q32), studies on the mechanism of lymphomagenesis are needed.
Hayama
Miyuki
M
Department of Hematology, Kitasato University, Sagamihara-shi, Kanagawa, Japan. mhayama@med.kitasato-u.ac.jp
Niitsu
Nozomi
N
Higashihara
Masaaki
M
Nakamine
Hirokazu
H
Miura
Ikuo
I
D000368:Aged; D018956:CD5 Antigens; D002883:Chromosomes, Human, Pair 14; D002896:Chromosomes, Human, Pair 6; D005192:Family Health; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D007621:Karyotyping; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D015260:Neprilysin; D013103:Spherocytosis, Hereditary / Q000175:diagnosis*; D014178:Translocation, Genetic
D018956:CD5 Antigens; D015260:Neprilysin