title: Treatment, by insertion of multiple uncovered metallic stents, of intraductal papillary mucinous neoplasm of the pancreas with biliary obstruction by mucus impaction.
abstract: OBJECTIVE
  Biliary mucinous obstruction is a complication of intraductal papillary mucinous neoplasms (IPMN). Surgery with resection of the tumour or with biliary bypass is generally recommended. It is our aim to report a patient with IPMN complicated by biliary mucinous impaction in whom surgery was not possible because of extensive collateral circulation. Repeated insertions of plastic and of single covered metallic stents were unsuccessful due to mucus-induced migration of these stents.
  
  
  METHODS
  Three metallic uncovered stents were inserted in the bile duct alongside each other in order to fill the bile duct up with stent material.
  
  
  RESULTS
  Whereas previous insertions of single plastic or covered metallic stents were invariably followed by recurrence of cholestasis by spontaneous stent migration, insertion of three uncovered metallic stents was followed by absence of any cholestatic symptoms during a follow-up period of at least 4 years.
  
  
  CONCLUSIONS
  In patients with IPMN complicated by biliary mucus impaction, the insertion of multiple uncovered metallic stents seems the endoscopic method of choice to prevent mucus-induced spontaneous stent dislocation.
authors: Unit for Liver, Biliary and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium.
authors: Laura
authors: L
authors: Seynaeve
authors: Werner
authors: W
authors: Van Steenbergen
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000150:complications / Q000601:surgery; D000231:Adenocarcinoma, Papillary / Q000150:complications / Q000601:surgery; D021441:Carcinoma, Pancreatic Ductal / Q000150:complications / Q000601:surgery; D005260:Female; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology* / Q000601:surgery*; D008875:Middle Aged; D009077:Mucins; D010190:Pancreatic Neoplasms / Q000150:complications / Q000601:surgery*; D015607:Stents
chemical_list: D009077:Mucins