Cytogenetic biclonality in a child with hypocellular primary myelodysplastic syndrome.
A 13-year-old boy with hypocellular primary myelodysplastic syndrome, classified as refractory cytopenia, underwent umbilical cord blood transplantation. Cytogenetic analysis revealed two rare biclonal chromosomal aberrations, del(17)(p12) and del(11)(q23). Cytogenetic analysis was a valuable tool in diagnosis, in clinical decision-making, and in treatment and follow-up. To our knowledge, this is the first reported case of cytogenetic biclonality involving chromosomes 17 and 11.
Rodrigues
Eliane Ferreira
EF
Cytogenetic Laboratory, Bone Marrow Transplant Center, National Cancer Institute (INCA), Praça Cruz Vermelha, CEP 20230-130, Rio de Janeiro, RJ, Brazil.
de Souza
Daiane Corrêa
DC
Camargo
Adriana
A
Tavares
Rita de Cássia
Rde C
Bouzas
Luiz Fernando
LF
Ornellas
Maria Helena
MH
Fernandez
Teresa de Souza
Tde S
D000293:Adolescent; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D020732:Cytogenetic Analysis; D003582:Cytogenetics; D005312:Fetal Blood / Q000378:metabolism; D017353:Gene Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D033581:Stem Cell Transplantation; D014180:Transplantation