Lifestyle intervention and adipokine levels in subjects at high risk for type 2 diabetes: the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht (SLIM).
OBJECTIVE
We investigated whether circulating adipokine concentrations can be altered by lifestyle intervention according to general recommendations in subjects at risk for diabetes as well as the potential of leptin, adiponectin, and resistin as biomarkers for lifestyle-induced improvements in glucose metabolism and insulin resistance.


METHODS
In the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht, 147 men and women with impaired glucose tolerance (IGT) were randomized to either a combined diet-and-exercise intervention or a control program. At baseline and after 1 year, an oral glucose tolerance test, an exercise test, and anthropometric measurements were performed. After 1 year, complete data of 103 subjects (50 intervention and 53 control subjects) were obtained.


RESULTS
Lifestyle intervention reduced plasma leptin concentrations (-14.2%) in IGT subjects but did not alter plasma adiponectin (-0.3%) or resistin (-6.5%) concentrations despite marked improvements in glucose tolerance and insulin resistance.


CONCLUSIONS
Changes in leptin concentration were related to improvements in insulin sensitivity independent of changes in body composition.
Corpeleijn
Eva
E
Human Biology, Nutrition and Toxicology Research Institute, Maastricht, the Netherlands. e.corpeleijn@hb.unimaas.nl
Feskens
Edith J M
EJ
Jansen
Eugène H J M
EH
Mensink
Marco
M
Saris
Wim H M
WH
Blaak
Ellen E
EE
D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D049628:Body Size; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control*; D003927:Diet, Diabetic; D015444:Exercise; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008019:Life Style; D008297:Male; D012016:Reference Values; D052243:Resistin / Q000097:blood*
D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D052243:Resistin