title: Carotid intima-media thickness and stiffness in relation to type 2 diabetes in Chinese.
abstract: We investigated carotid intima-media thickness (IMT) and quantitative carotid stiffness (QCS) index in relation to plasma glycosylated hemoglobin A(1C) (HbA(1C)) and duration of diabetes mellitus in 337 Chinese diabetic patients. In categorical analyses, carotid IMT was 710 mum in subjects with a duration of diabetes mellitus < or = 2 years, 760 micorm in subjects with a duration of diabetes mellitus more than two years and with plasma HbA(1C) < 6.5% (P < 0.05), and 790 microm in subjects with a duration of diabetes mellitus more than two years but with plasma HbA(1C) > or = 6.5% (P < 0.01). The corresponding values for QCS values were 4.5, 4.6 and 5.1 (P < 0.05), respectively. In multiple stepwise regression analyses carotid IMT was significantly associated with the duration of diabetes mellitus, systolic blood pressure and serum concentration of total cholesterol, whereas QCS was significantly associated with age, HbA(1C), systolic and diastolic blood pressure (P < 0.05). In conclusion, carotid IMT as a structural measure of arterial wall is increased in patients with a longer history of diabetes mellitus, whereas QCS as functional index is mainly influenced by the quality of blood glucose control.
authors: Department of Ultrasonography, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197 Ruijin 2nd Road, Shanghai 200025, P.R. China.
authors: Yan-Ping
authors: YP
authors: Liu
authors: Wei-Wei
authors: WW
authors: Zhan
authors: Yi-Fei
authors: YF
authors: Zhang
authors: Yu-Hong
authors: YH
authors: Chen
authors: Yan-Yan
authors: YY
authors: Lin
authors: Ying
authors: Y
authors: Zhu
authors: Xin-Ping
authors: XP
authors: Ren
authors: Xiao-Ying
authors: XY
authors: Li
authors: Guang
authors: G
authors: Ning
mesh_terms: D000367:Age Factors; D044466:Asian People; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin