Receiving mixed signals: uncoupling oligodendrocyte differentiation and myelination.
The development and maturation of an oligodendroglial cell is comprised of three intimately related processes that include proliferation, differentiation, and myelination. Here we review how proliferation and differentiation are controlled by distinct molecular mechanisms and discuss whether differentiation is merely a default of inhibited proliferation. We then address whether differentiation and myelination can be uncoupled in a similar manner. This task is particularly challenging because an oligodendrocyte cannot myelinate without first differentiating, and these processes are therefore not mutually exclusive. Is it solely the presence of the axon that distinguishes a differentiated oligodendrocyte from a myelinating one? Uncoupling these two processes requires identifying specific signals that regulate myelination without affecting the differentiation process. We will review current understanding of the relationship between differentiation and myelination and discuss whether these two processes can truly be uncoupled.
Rosenberg
S S
SS
Zilkha Neurogenetic Institute,Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, 1501 San Pablo St. ZNI 421, Los Angeles, California 90033, USA.
Powell
B L
BL
Chan
J R
JR
D000818:Animals; D001369:Axons / Q000502:physiology; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D009185:Myelin Proteins / Q000378:metabolism*; D009836:Oligodendroglia / Q000502:physiology*; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology
D009185:Myelin Proteins