Choroidal and optic nerve infarction in hepatitis C-associated polyarteritis nodosa.
A 39-year-old man presented with headache, weight loss, bilateral subdural hematomas, pansinusitis, and visual loss. The neuro-ophthalmologic examination disclosed deep choroidal lesions and bilateral optic disc edema. Orchiectomy for testicular torsion showed acute vasculitis consistent with polyarteritis nodosa (PAN). Polymerase chain reaction (PCR) testing revealed hepatitis C. This is the first reported case of PAN due to hepatitis C with early findings of choroidal and optic nerve infarction.
Kostina-O'Neil
Yanina
Y
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06510, USA. ykostina@theeyecaregroup.com
Jirawuthiworavong
Guy V
GV
Podell
David N
DN
Lesser
Robert L
RL
D000328:Adult; D020520:Brain Infarction / Q000473:pathology / Q000503:physiopathology / Q000821:virology*; D002829:Choroid / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D015862:Choroid Diseases / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D003520:Cyclophosphamide / Q000627:therapeutic use; D018450:Disease Progression; D020199:Hematoma, Subdural, Acute / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009880:Ophthalmic Artery / Q000473:pathology / Q000503:physiopathology; D009900:Optic Nerve / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000473:pathology / Q000503:physiopathology / Q000821:virology*; D010211:Papilledema / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000503:physiopathology / Q000821:virology; D016896:Treatment Outcome
D003520:Cyclophosphamide; D008775:Methylprednisolone