title: Localization of metabotropic glutamate receptors in the outer plexiform layer of the goldfish retina.
abstract: We studied the localization of metabotropic glutamate receptors (mGluRs) in the goldfish outer plexiform layer by light-and electron-microscopical immunohistochemistry. The mGluR1alpha antibody labeled putative ON-type bipolar cell dendrites and horizontal cell processes in both rod spherules and cone triads. Immunolabeling for mGluR2/3 was absent in the rod synaptic complex but was found at horizontal cell dendrites directly opposing the cone synaptic ribbon. The mGluR5 antibody labeled Müller cell processes wrapping rod terminals and horizontal cell somata. The mGluR7 antibody labeled mainly horizontal cell dendrites invaginating rods and cones and some putative bipolar cell dendrites in the cone synaptic complex. The finding of abundant expression of various mGluRs in bipolar and horizontal cell dendrites suggests multiple sites of glutamatergic modulation in the outer retina.
authors: Retinal Signal Processing, The Netherlands Institute for Neuroscience (KNAW), Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.
authors: Christina
authors: C
authors: Joselevitch
authors: Jan
authors: J
authors: Klooster
authors: Maarten
authors: M
authors: Kamermans
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D006054:Goldfish / Q000378:metabolism*; D015151:Immunoblotting; D008854:Microscopy, Electron; D008954:Models, Biological; D018094:Receptors, Metabotropic Glutamate / Q000032:analysis* / Q000276:immunology / Q000378:metabolism; D017949:Retinal Cone Photoreceptor Cells / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D018094:Receptors, Metabotropic Glutamate