title: Acquired cold urticaria symptoms can be safely prevented by ebastine.
abstract: BACKGROUND
  Acquired cold urticaria (ACU) is a skin condition, in which exposure to cold results in wheals and itching and sometimes general systemic complications. It has a profound impact on patient quality of life. Second-generation antihistamines are recommended as the first-line treatment, but to date only a few have been scientifically tested for this condition.
  
  
  OBJECTIVE
  To assess the safety and efficacy of ebastine in preventing ACU symptoms.
  
  
  METHODS
  Twenty-two adult ACU patients participated in a double-blind crossover trial of 20 mg ebastine. The safety of ebastine was sensitively assessed with a psychometric battery testing cognitive performance and mood. After cold challenge, wheal and erythema were assessed by the investigator and the intensities of pruritus and burning were rated by the subject.
  
  
  RESULTS
  Ebastine had no negative impact on any of the parameters of cognitive performance or mood. It dramatically reduced the number of patients who experienced wheals, pruritus, and burning after challenge.
  
  
  CONCLUSIONS
  Ebastine is safe and effective in preventing the symptoms of ACU.
authors: Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité- Universitätsmedizin Berlin, Berlin, Germany.
authors: M
authors: M
authors: Magerl
authors: J
authors: J
authors: Schmolke
authors: F
authors: F
authors: Siebenhaar
authors: T
authors: T
authors: Zuberbier
authors: M
authors: M
authors: Metz
authors: M
authors: M
authors: Maurer
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D002090:Butyrophenones / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D003080:Cold Temperature / Q000009:adverse effects*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D011594:Psychometrics; D016896:Treatment Outcome; D014581:Urticaria / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D002090:Butyrophenones; D006634:Histamine H1 Antagonists; D010880:Piperidines; C058249:ebastine