Signalling pathways mediating type I interferon gene expression.
Type I interferon-alpha/beta play an essential role in immunity to viruses. While interferon-beta has been used as a model of a complex promoter, many of the signalling pathways leading to interferon-beta gene expression remain controversial. Recent milestones include the discovery of Toll-like receptors and RNA helicases that signal via a novel kinase complex composed of I kappa B kinase-iota/epsilon or TANK binding kinase-1. This review provides a timely summary of this rapidly expanding field, focusing specifically on the various viral RNA binding molecules and their associated signalling pathways.
Edwards
Michael R
MR
Department of Respiratory Medicine, National Heart and Lung Institute, MRC Centre in Allergic Mechanisms of Asthma, St Marys Campus, Norfolk Place, London W2 1PG, UK. michael.edwards@imperial.ac.uk
Slater
Louise
L
Johnston
Sebastian L
SL
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D007370:Interferon Type I / Q000235:genetics* / Q000276:immunology; D012367:RNA, Viral / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology; D014780:Viruses / Q000276:immunology
D007370:Interferon Type I; D012367:RNA, Viral; D051193:Toll-Like Receptors