title: A high spatial resolution 1H magnetic resonance spectroscopic imaging technique for breast cancer with a short echo time.
abstract: The high sensitivity but low specificity of breast MRI has prompted exploration of breast (1)H MRS for breast cancer detection. However, several obstacles still prevent the routine application of in vivo breast (1)H MRS, including poor spatial resolution, long acquisition time associated with conventional multi-voxel MRS imaging (MRSI) techniques, and the difficulty of "extra" lipid suppression in a magnetic field with relatively poor achievable homogeneity compared to the brain. Using a combination of a recently developed echo-filter (EF) suppression technique and an elliptical sampling scheme, we demonstrate the feasibility of overcoming these difficulties. It is robust (the suppression technique is insensitive to magnetic field inhomogeneity), fast (acquisition time of about 12 min) and offers high spatial resolution (up to 0.6 cm(3) per voxel at 1.5 T with a TE of only 60 ms). This approach should be even better at 3 T with higher resolution and/or shorter TE.
authors: Department of Radiology, Wayne State University, Detroit, MI 48201, USA. jhu@med.wayne.edu
authors: Jiani
authors: J
authors: Hu
authors: Yingjian
authors: Y
authors: Yu
authors: Zhifeng
authors: Z
authors: Kou
authors: Wei
authors: W
authors: Huang
authors: Quan
authors: Q
authors: Jiang
authors: Yang
authors: Y
authors: Xuan
authors: Tao
authors: T
authors: Li
authors: Vivek
authors: V
authors: Sehgal
authors: Cassann
authors: C
authors: Blake
authors: E Mark
authors: EM
authors: Haacke
authors: Renate L
authors: RL
authors: Soulen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media