Utilization of extended donor criteria in liver transplantation: a comprehensive review of the literature.
Organ shortage has driven many transplant programs to extend their criteria to accept donors. The goal of the present work is to further characterize the most important extended donor criteria (EDC) in liver transplantation and to identify factors that impact outcomes for this type of grafts through a comprehensive review of the most recent findings and current opinions. Age, steatosis, positive viral hepatitis serology, intensive care unit stay, and history of malignancy in donor have been the matter of substantial debate in recent years and are therefore discussed in further detail here. Cold and warm ischemic times have also been discussed separately as they have been identified as important independent risk factors for mortality. The use of grafts with EDC provides an immediate expansion of the donor pool. However, in order to optimize effective utilization of EDC, attempts should be made to carefully match the most appropriate graft-recipient pair.
Nickkholgh
Arash
A
Dept. of General Surgery, Ruprecht-Karls-University, INF 110, 69120 Heidelberg, Germany.
Weitz
Jürgen
J
Encke
Jens
J
Sauer
Peter
P
Mehrabi
Arianeb
A
Büchler
Markus W
MW
Schmidt
Jan
J
Schemmer
Peter
P
D000328:Adult; D000367:Age Factors; D000368:Aged; D006085:Graft Survival; D006801:Humans; D007511:Ischemia; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008875:Middle Aged; D012042:Registries; D012044:Regression Analysis; D012307:Risk Factors; D009927:Tissue and Organ Procurement / Q000379:methods; D016896:Treatment Outcome; D052096:Warm Ischemia