title: Using a refrigerant leak detector to monitor waste gases from halogenated anesthetics.
abstract: Although halogenated gas anesthetics are indispensable in laboratory animal medicine, they are hazardous when present in the working environment. A simple technique of real-time leak detection and environmental spot monitoring can provide valuable adjunct information to current techniques of time-weighted monitoring. We investigated the minimal limit of detection of halothane, isoflurane, sevoflurane, and desflurane of a leak detector for halogenated gas refrigerants which provides a qualitative response only. We connected a container to an infrared gas analyzer to create a 135-l closed-circuit system and injected liquid halothane, isoflurane, sevoflurane, and desflurane to create calculated gas concentrations of 0.7 to 3.4 parts per million (ppm). The infrared absorbance and response of the leak detector were recorded, and a total of 5 measurements were made per concentration. The actual gas concentrations were calculated by comparison with the agent-specific absorbance standard curve. The leak detector clearly and consistently responded to halothane, isoflurane, sevoflurane, and desflurane from minimal concentrations of 2.1 +/- 0.2, 1.4 +/- 0.04, 0.8 +/- 0.04, and 1.2 +/- 0.4 ppm, respectively, as determined by infrared analysis. Although the detector does not provide numerical and time-weighted results, leak testing of equipment and repeated monitoring of the environment (spot monitoring) can provide valuable real-time information. In addition, with appropriate consideration of the methodological limitations, spot monitoring can be used to predict the likelihood of compliance with time-weighted exposure recommendations. A leak detector therefore represents a simple, effective, and inexpensive instrument for monitoring the leakage of halogenated anesthetic gases from equipment and into the working environment.
authors: GE Healthcare, Oslo, Norway. henrikrasmussen@ge.com
authors: Henrik
authors: H
authors: Rasmussen
authors: Syvert
authors: S
authors: Thorud
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis*; D018685:Anesthetics, Inhalation / Q000032:analysis*; D004784:Environmental Monitoring / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D005740:Gases / Q000032:analysis*; D006846:Hydrocarbons, Halogenated / Q000032:analysis*; D007756:Laboratory Animal Science / Q000295:instrumentation* / Q000379:methods; D016273:Occupational Exposure / Q000517:prevention & control*; D012034:Refrigeration
chemical_list: D000395:Air Pollutants, Occupational; D018685:Anesthetics, Inhalation; D005740:Gases; D006846:Hydrocarbons, Halogenated