Artery and vein formation: a tug of war between different forces.
How arterial and venous fates are established is largely unknown. In the past, circulatory dynamics were thought to be the exclusive cause of arteries and veins being structurally and functionally distinct; however, growing evidence indicates that an orderly progression of molecular signals controls arterial-venous specification in the developing vertebrate vascular system.
Lin
Fu-Jung
FJ
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
Tsai
Ming-Jer
MJ
Tsai
Sophia Y
SY
D000818:Animals; D001158:Arteries / Q000196:embryology*; D051837:COUP Transcription Factor II / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000378:metabolism; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D014680:Veins / Q000196:embryology*
D051837:COUP Transcription Factor II; D051858:Forkhead Transcription Factors; D053823:Hedgehog Proteins