Effects of angiotensin II and captopril on rewarding properties of morphine.
The effects of captopril and Ang II on morphine-induced conditioned place preference (CPP) and morphine self-administration in male Wistar rat were investigated. In CPP experiment, injection of captopril before test significantly decreased the difference of the time spent in compartment A between pre- and post-conditioning compared to morphine group. In self- administration experiment number of active lever pressing was significantly greater than passive in morphine group. In captopril group number of active lever pressing was significantly lower than morphine group however, there was not significant difference between active and passive lever pressed number. The results showed that captopril significantly decreased morphine-induced conditional place preference and morphine self-administration but the effect of Ang II was not significant. It can be concluded that RAS may have a role in rewarding properties of morphine.
Hosseini
Mahmoud
M
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. smhosseini49@hotmail.com
Sharifi
Mohammad Reza
MR
Alaei
Hojatallah
H
Shafei
Mohammad Naser
MN
Karimooy
Habib Allah Nemati
HA
D000804:Angiotensin II / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D003213:Conditioning, Psychological; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D012201:Reward; D012646:Self Administration
D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D009020:Morphine; D002216:Captopril