title: Interfrontal commissural abnormality in schizophrenia: tractography-assisted callosal parcellation.
abstract: Previous studies have indicated abnormal fiber connectivity of the corpus callosum (CC) in schizophrenia. This study investigated whether the interfrontal commissural region of the CC is decreased in schizophrenia, by partitioning the CC using a function-anatomically relevant internal landmark derived from tractographic analysis of diffusion tensor imaging (DTI). T1 weighted and DTI images were acquired by 3T-MRI. Using tractography, the interfrontal commissural region (anterior part) was partitioned from the rest of the CC in 40 schizophrenia patients and 36 healthy controls. Schizophrenia patients showed smaller anterior/total CC length and area rates. These results suggested interfrontal hypoconnectivity in schizophrenia.
authors: Department of Neuropsychiatry, Graduate School of Medicine, Kyoto University, Shogoin-Kawaharacho 54, Kyoto 606-8507, Japan. miyata10@kuhp.kyoto-u.ac.jp
authors: Jun
authors: J
authors: Miyata
authors: Kazuyuki
authors: K
authors: Hirao
authors: Chihiro
authors: C
authors: Namiki
authors: Hidenao
authors: H
authors: Fukuyama
authors: Tsutomu
authors: T
authors: Okada
authors: Yukio
authors: Y
authors: Miki
authors: Takuji
authors: T
authors: Hayashi
authors: Toshiya
authors: T
authors: Murai
mesh_terms: D000328:Adult; D061085:Agenesis of Corpus Callosum; D003337:Corpus Callosum / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D010296:Parietal Lobe / Q000002:abnormalities / Q000473:pathology; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis*