title: Mucoepidermoid carcinoma of the lung: high-resolution CT and histopathologic findings in five cases.
abstract: OBJECTIVE
  The purpose of this study was to characterize the high-resolution computed tomography (HRCT) findings of mucoepidermoid carcinoma of the lung and correlate them with the histopathological features.
  
  
  METHODS
  The study included five patients with pathologically proven mucoepidermoid carcinoma who underwent HRCT before treatment. The HRCT findings were then compared with the histopathological features in all patients.
  
  
  RESULTS
  The HRCT images showed lesions in the central lung in four patients and in the peripheral lung in one. All the lesions were well defined nodules or masses with a smooth margin. The contour of the tumours was oval (n=3), round (n=1) or lobulated (n=1). The contrast-enhanced CT images showed marked heterogeneous enhancement with foci of relatively low attenuation in four of the five lesions and mild heterogeneous enhancement in the other lesion. There was an admixed distribution of areas that are heterogeneous in the densities of blood vessels, as highlighted by immunohistochemical staining of CD31. Most mucin-secreting areas of the tumours showed more densely distributed blood vessels, mostly capillaries, in between tumour cell nests, whereas other areas did less. All five patients in our series underwent lobectomy plus lymph node dissection or sampling. All the patients are alive without evidence of disease an average of 50.4 months after surgery (range, 15-82 months; median, 57 months).
  
  
  CONCLUSIONS
  Mucoepidermoid carcinoma of the bronchus is often visualized as marked heterogeneous contrast enhancement on HRCT images. The results of this study suggest that the presence of abundant microvessels, detected immunohistochemically by microscopic examination, affects the enhancement pattern on HRCT.
authors: Divisions of Diagnostic Radiology and Nuclear Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-Ku, 104-0045 Tokyo, Japan; Divisions of Thoracic Surgery, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-Ku, 104-0045 Tokyo, Japan. Electronic address: tishizumi@hotmail.co.jp.
authors: Taichiro
authors: T
authors: Ishizumi
authors: Divisions of Diagnostic Radiology and Nuclear Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-Ku, 104-0045 Tokyo, Japan.
authors: Ukihide
authors: U
authors: Tateishi
authors: Divisions of Thoracic Surgery, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-Ku, 104-0045 Tokyo, Japan.
authors: Shun-Ichi
authors: SI
authors: Watanabe
authors: Divisions of Pathology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-Ku, 104-0045 Tokyo, Japan.
authors: Yoshihiro
authors: Y
authors: Matsuno
mesh_terms: D000328:Adult; D001999:Bronchoscopy; D018277:Carcinoma, Mucoepidermoid / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods*