title: The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis.
abstract: In this study we observed higher serum leptin levels in relapsing-remitting multiple sclerosis (RRMS) patients during remission than in controls. The expression of leptin receptor (ObR) was higher in CD8+ T cells and monocytes from RRMS patients in relapse than in patients in remission and in controls. Relapsing patients showed high levels of pSTAT3 and low expression of SOCS3 and leptin administration induced an up-regulation of pSTAT3 only in monocytes from patients in relapse. Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS.
authors: Istituto di Neurologia, Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168 Roma, Italy.
authors: Giovanni
authors: G
authors: Frisullo
authors: Massimiliano
authors: M
authors: Mirabella
authors: Francesco
authors: F
authors: Angelucci
authors: Marcella
authors: M
authors: Caggiula
authors: Roberta
authors: R
authors: Morosetti
authors: Cristina
authors: C
authors: Sancricca
authors: Agata Katia
authors: AK
authors: Patanella
authors: Viviana
authors: V
authors: Nociti
authors: Raffaele
authors: R
authors: Iorio
authors: Assunta
authors: A
authors: Bianco
authors: Valentina
authors: V
authors: Tomassini
authors: Carlo
authors: C
authors: Pozzilli
authors: Pietro Attilio
authors: PA
authors: Tonali
authors: Giuseppe
authors: G
authors: Matarese
authors: Anna Paola
authors: AP
authors: Batocchi
mesh_terms: D000328:Adult; D001427:Bacterial Toxins / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000378:metabolism; D006460:Hemolysin Proteins / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000473:pathology; D011863:Radioimmunoassay / Q000379:methods; D054411:Receptors, Leptin / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D001427:Bacterial Toxins; D016207:Cytokines; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; D020738:Leptin; D054411:Receptors, Leptin; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C038705:hlyA protein, Listeria monocytogenes