Endocytosis of neurotransmitter receptors: location matters.
Endocytosis of excitatory glutamate receptors from the postsynaptic plasma membrane plays a fundamental role in synaptic function and plasticity. In a recent study published in Neuron, Lu et al. (2007) describe protein interactions that link zones of receptor endocytosis directly to the postsynaptic scaffold and propose that local trafficking of receptors facilitated by these endocytic zones is required to maintain synaptic responsiveness.
Puthenveedu
Manojkumar A
MA
Department of Psychiatry and Department of Cellular & Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.
Yudowski
Guillermo A
GA
von Zastrow
Mark
M
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002966:Clathrin / Q000378:metabolism*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism*; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism*; D003712:Dendrites / Q000378:metabolism; D034286:Dynamin III / Q000378:metabolism; D004705:Endocytosis; D019706:Excitatory Postsynaptic Potentials; D000072233:Homer Scaffolding Proteins; D006801:Humans; D046912:Multiprotein Complexes / Q000378:metabolism; D009473:Neuronal Plasticity; D021381:Protein Transport; D018091:Receptors, AMPA / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*; D013572:Synaptic Vesicles / Q000378:metabolism
D002352:Carrier Proteins; D002966:Clathrin; D000072233:Homer Scaffolding Proteins; D046912:Multiprotein Complexes; D018091:Receptors, AMPA; D034286:Dynamin III