Beneficial effects of cardiac rehabilitation and exercise after percutaneous coronary intervention on hsCRP and inflammatory cytokines in CAD patients.
Recent studies showed that tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), as well as high-sensitive C-reactive protein (hsCRP) levels are predictive factors of cardiovascular risk. However, the effect of cardiac rehabilitation (CR) intervention in coronary artery disease (CAD) patients on these factors is not known. The aim of this study was to evaluate the effects of CR and exercise on hsCRP and inflammatory cytokine levels in patients with CAD after percutaneous coronary intervention (PCI). CAD patients who underwent PCI were divided into a CR and exercise group (CRE, n = 29) or a control group (CON, n = 10). CR and exercise consisted of 6 weeks supervised exercise training and 8 weeks home-based, self-managed exercise. Compared to pre-experimental levels, TNF-alpha (by 20.4%; p = 0.006) and IL-6 (by 49.0%; p < 0.0001), as well as hsCRP (by 59.4%; p < 0.0001), were markedly decreased after CR and exercise in CAD patients but not in control group, except for IL-6 (by 41.6%; p = 0.001). However, there was no significant alteration of adiposity-related variables such as BMI, percent body fat, and waist circumferences, in both groups. We suggest that CR and exercise in CAD patients after PCI induce significant reduction in hsCRP and inflammatory cytokines (TNF-alpha and IL-6), and marked increase in exercise tolerance and capacity.
Kim
Young-Joo
YJ
Department of Rehabilitation Medicine, College of Medicine, Inje University, Seoul, Republic of Korea.
Shin
Young-Oh
YO
Bae
Jun-Sang
JS
Lee
Jeong-Beom
JB
Ham
Joo-Hyun
JH
Son
Youn-Jung
YJ
Kim
Jung-Kyu
JK
Kim
Chul
C
Lee
Byoung-Kwon
BK
Oh
Jae-Keun
JK
Othman
Timothy
T
Min
Young-Ki
YK
Yang
Hun-Mo
HM
D050154:Adiposity / Q000502:physiology; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000503:physiopathology* / Q000534:rehabilitation*; D016207:Cytokines / Q000378:metabolism*; D005080:Exercise Test; D005081:Exercise Therapy; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006334:Heart Function Tests; D006801:Humans; D007958:Leukocyte Count; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; D005340:Fibrinogen; D002097:C-Reactive Protein