Cytomegalovirus infection in seronegative patients treated with prophylaxis: case-controlled study.
Primary cytomegalovirus (CMV) infection is common in infancy with approximately 90% to 95% of subjects developing antibodies against this virus. CMV seronegative renal allograft recipients generally receive this infection with a graft or with blood transfusions, showing a high morbidity and mortality. Prophylaxis in these patients has shown good results; however, the published studies have included a small number of patients. Our case-controlled study evaluated 163 kidney transplant recipients: 76 seronegatives for CMV and 87 seropositive for CMV as controls. The evaluated parameters were: CMV infection, CMV disease, renal function, and survival of the patient and graft. We studied our experience among CMV seronegative patients treated with various prophylaxis guidelines. Our conclusions were that CMV prophylaxis in seronegative patients was effective because it showed a risk of infection that was equal (or even less) than that in seropositive patients and revealed a delay in the onset of the disease. CMV seronegativity may be a positive prognostic factor for graft survival.
Moreno de la Higuera Díaz
M A
MA
Department of Nephrology and Renal Transplantation, Hospital Clinico San Carlos, Profesor Martín Lagos s/n, Madrid, Spain. angie.moreno@gmail.com
Calvo Romero
N
N
Sánchez-Fructuoso
A
A
Conesa
J
J
Marques Vidas
M
M
Prats
D
D
Barrientos Guzmán
A
A
D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000517:prevention & control; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D011183:Postoperative Complications / Q000821:virology; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data; D065227:Transfusion Reaction
D000998:Antiviral Agents; D007166:Immunosuppressive Agents