Extended-spectrum beta-lactamase-type SHV-12-producing Enterobacteriaceae causing septicemia in Tanzanian children: vectors for horizontal transfer of antimicrobial resistance.
Septicemia caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae was associated with high mortality in Tanzanian children. Conjugation experiments on the SHV-12-producing Enterobacteriaceae isolates showed that ESBL-encoding genes were transferred on large plasmids together with genes encoding resistance to aminoglycosides, resistance to ceftazidime, gentamicin, doxycycline, trimethoprim-sulfamethoxazole, and chloramphenicol.
Tellevik
Marit Gjerde
MG
Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway. marit.gjerde@med.uib.no
Sollid
Johanna Ericson
JE
Blomberg
Bjørn
B
Jureen
Roland
R
Urassa
Willy K
WK
Langeland
Nina
N
D002648:Child; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D011446:Prospective Studies; D018805:Sepsis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D013636:Tanzania / Q000453:epidemiology; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
C107198:beta-lactamase SHV-12; D001618:beta-Lactamases