Rifampicin-associated segmental necrotizing glomerulonephritis in staphylococcal endocarditis.
Segmental necrotising glomerulonephritis has been reported as complication of rifampicin therapy in patients receiving treatment for tuberculosis. Changing epidemiology of infections such as infective endocarditis (IE) has led to an increase in the use of rifampicin for Staphylococcal infections. We describe a case of a patient with Staphylococcal IE who developed acute renal failure secondary to a segmental necrotising glomerulonephritis while being treated with rifampicin, and review the literature regarding this complication of rifampicin therapy.
Wiggins
Kathryn J
KJ
Department of Renal Medicine, St Vincent's Hospital, Melbourne, Victoria, Australia. kate.wiggins@svhm.org.au
Galanos
Jason W
JW
Hill
Prue A
PA
Scott
Kirsten V
KV
Langham
Robyn G
RG
D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000009:adverse effects* / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D006801:Humans; D009336:Necrosis; D012293:Rifampin / Q000009:adverse effects* / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus
D000904:Antibiotics, Antitubercular; D012293:Rifampin