Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder.
Brain-derived neurotrophic factor val66met polymorphism has been implicated in the pathophysiology of bipolar disorder. We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor val66met polymorphism using H-magnetic resonance spectroscopy. Absolute N-acetyl-aspartate, phosphocreatine+creatine (PCr+Cr), choline-containing compounds, myo-inositol, and glutamate levels were measured. Bipolar disorder met-carriers had lower PCr+Cr levels than bipolar disorder val/val patients, and bipolar disorder val/val patients had higher PCr+Cr levels than val/val healthy controls. These results indicate that bipolar disorder met-carriers have abnormal energy metabolism in the left dorsolateral prefrontal cortex.
Frey
Benicio N
BN
Department of Psychiatry, Psychiatric Genetics Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Walss-Bass
Consuelo
C
Stanley
Jeffrey A
JA
Nery
Fabiano G
FG
Matsuo
Koji
K
Nicoletti
Mark A
MA
Hatch
John P
JP
Bowden
Charles L
CL
Escamilla
Michael A
MA
Soares
Jair C
JC
D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics / Q000502:physiology; D001224:Aspartic Acid / Q000378:metabolism; D001714:Bipolar Disorder / Q000235:genetics* / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics* / Q000502:physiology*; D003401:Creatine / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008715:Methionine / Q000502:physiology; D010725:Phosphocreatine / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000502:physiology*; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D014633:Valine / Q000502:physiology
D019208:Brain-Derived Neurotrophic Factor; D010725:Phosphocreatine; D001224:Aspartic Acid; D008715:Methionine; D014633:Valine; D003401:Creatine