title: Platelet-rich plasma may not provide any additional effect when associated with guided bone regeneration around dental implants in dogs.
abstract: OBJECTIVE
  The aim of this study was to evaluate histometrically bone healing in surgically created dehiscence-type defects around titanium implants treated with an association of platelet-rich plasma (PRP) and guided bone regeneration (GBR).
  
  
  METHODS
  Ten male adult mongrel dogs were used, from which the three low premolars (P2, P3, P4) and the first molar were extracted. Three months after teeth extraction, two implant sites were bilaterally drilled, buccal bone dehiscences were created and four titanium implants were placed. Dehiscences were randomly assigned to the following groups: (1) PRP, (2) GBR, (3) PRP+GBR and (4) control. After 3 months, the animals were sacrificed and the implants and adjacent hard tissues were processed for undecalcified sections. Bone-to-implant contact (BIC), bone density within the limits of implant threads (BW), bone density (BD) and new bone area (BA) in a zone lateral to the implant corresponding to bone defects were obtained and measured.
  
  
  RESULTS
  Intergroup analysis (two-way ANOVA -alpha=5%) demonstrated that when PRP was utilized,no differences were observed for all parameters (P>0.05). However, significant differences were observed for BIC and BW toward membrane-treated groups (P<0.05).
  
  
  CONCLUSIONS
  Within the limits of this study, it was concluded that PRP does not exert additional effects on bone healing in bone defects created around dental implants and treated by GBR.
authors: Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Piracicaba/Unicamp, São Paulo, Brazil.
authors: Bruno César
authors: BC
authors: de Vasconcelos Gurgel
authors: Patrícia Furtado
authors: PF
authors: Gonçalves
authors: Suzana Peres
authors: SP
authors: Pimentel
authors: Gláucia Maria Bovi
authors: GM
authors: Ambrosano
authors: Francisco Humberto
authors: FH
authors: Nociti Júnior
authors: Enilson Antonio
authors: EA
authors: Sallum
authors: Marcio Zaffalon
authors: MZ
authors: Casati
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology*; D015921:Dental Implants; D003764:Dental Materials; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal; D008297:Male; D008334:Mandible / Q000601:surgery; D008336:Mandibular Diseases / Q000601:surgery; D008567:Membranes, Artificial; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D053657:Platelet-Rich Plasma / Q000502:physiology*; D011138:Polytetrafluoroethylene; D011897:Random Allocation; D013529:Surgical Wound Dehiscence / Q000601:surgery; D013997:Time Factors; D014025:Titanium
chemical_list: D015921:Dental Implants; D003764:Dental Materials; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene; D014025:Titanium