CAG repeat length variation in the androgen receptor gene is not associated with spermatogenic failure.
Previous association studies that described the effect of an enlarged CAG repeat length in the Androgen Receptor (AR) gene on spermatogenesis could not prove or refute a true association because of methodological weaknesses. Here, we clearly show that there is no association between CAG repeat length variation and semen quality.
Westerveld
Henrike
H
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, the Netherlands. g.h.westerveld@amc.uva.nl
Visser
Liesbeth
L
Tanck
Michael
M
van der Veen
Fulco
F
Repping
Sjoerd
S
D000328:Adult; D048430:Cell Shape; D015331:Cohort Studies; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011944:Receptors, Androgen / Q000235:genetics*; D013076:Sperm Count; D013081:Sperm Motility; D013091:Spermatogenesis / Q000235:genetics*; D013094:Spermatozoa / Q000473:pathology*; D018911:Trinucleotide Repeats
C410798:AR protein, human; D011944:Receptors, Androgen