An investigation into the tether length and substitution pattern of arene-substituted complexes for asymmetric transfer hydrogenation of ketones.
A series of Ru(II) catalysts were prepared and tested in the asymmetric transfer hydrogenation of ketones. The catalyst containing a "4-carbon" tether gave the fastest rates of ketone reduction. This is due to both increased rate of regeneration of hydride "Ru-H" and increased rate of ketone reduction. Several classes of ketone were reduced in enantiomeric excesses of up to 97%. Substituents on the arene ring of the catalyst influence the reaction rate and enantioselectivity.
Cheung
Fung K
FK
Asymmetric Catalysis Group, Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Lin
Changxue
C
Minissi
Franco
F
Crivillé
Adriana Lorente
AL
Graham
Mark A
MA
Fox
David J
DJ
Wills
Martin
M