Dizocilpine-induced accuracy deficits in a visual signal detection task are not present following D-cycloserine administration in rats.
The N-methyl-D-aspartate (NMDA) receptor system is thought to be underactive in schizophrenia which may contribute to attentional dysfunction in this disease. In a visual signal detection task that required discrimination of signaled-trials from trials with no signal, the NMDA receptor antagonist, dizocilpine (0.05 mg/kg), increased errors on non-signal trials. Co-administration of dizocilpine and 10.0 mg/kg D-cycloserine, a co-agonist at the glycine site on the NMDA receptor, significantly decreased the error rate on non-signal trials compared to dizocilpine alone. These results suggest that drugs targeting the glycine site may be beneficial for attenuating attentional deficits associated with an underactive NMDA receptor system.
Howe
W Matthew
WM
Department of Psychology, The College of William and Mary, Williamsburg, VA 23187, United States.
Burk
Joshua A
JA
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D001665:Binding Sites; D003523:Cycloserine / Q000494:pharmacology*; D016291:Dizocilpine Maleate / Q000633:toxicity*; D018691:Excitatory Amino Acid Antagonists / Q000633:toxicity*; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D020318:Rats, Long-Evans; D018009:Receptors, Glycine / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists; D017603:Signal Detection, Psychological / Q000187:drug effects*; D014796:Visual Perception / Q000187:drug effects*
D000963:Antimetabolites; D018691:Excitatory Amino Acid Antagonists; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D003523:Cycloserine