Effect of adenosine on the growth of human T-lymphocyte leukemia cell line MOLT-4.
Adenosine has been observed to suppress the growth of MOLT-4 human leukemia cells in vitro. Changes in the cell cycle, especially increased percentage of cells in S phase, prolonged generation time, and induction of apoptosis at higher adenosine concentrations have been found to be responsible for the growth suppression. Dipyridamole, a drug inhibiting the cellular uptake of adenosine, reversed partially but significantly the adenosine-induced growth suppression. It follows from these results that the action of adenosine on the MOLT-4 cells comprises its cellular uptake and intracellular operation. These findings present new data on anticancer efficacy of adenosine.
Streitová
Denisa
D
Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic. streitova@ibp.cz
Weiterová
Lenka
L
Hofer
Michal
M
Holá
Jirina
J
Horváth
Viktor
V
Kozubík
Alois
A
Znojil
Vladimír
V
D000241:Adenosine / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D017209:Apoptosis; D001692:Biological Transport / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004176:Dipyridamole / Q000494:pharmacology; D006801:Humans; D015458:Leukemia, T-Cell / Q000473:pathology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology
D000970:Antineoplastic Agents; D010726:Phosphodiesterase Inhibitors; D004176:Dipyridamole; D000241:Adenosine