title: Evolution of enzymes and pathways for the biosynthesis of cofactors.
abstract: The evolution of metabolic pathways is discussed with reference to the biosynthesis of a number of vitamins and cofactors. Retrograde and patchwork models are highlighted and their relevance to our knowledge of pathway processes and enzymes is examined. Pathway complexity is explained in terms of the acquisition of broad specificity enzymes.
authors: European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK CB10 1SD. gemma@ebi.ac.uk
authors: Gemma L
authors: GL
authors: Holliday
authors: Janet M
authors: JM
authors: Thornton
authors: Andrée
authors: A
authors: Marquet
authors: Alison G
authors: AG
authors: Smith
authors: Fabrice
authors: F
authors: Rébeillé
authors: Ralf
authors: R
authors: Mendel
authors: Heidi L
authors: HL
authors: Schubert
authors: Andrew D
authors: AD
authors: Lawrence
authors: Martin J
authors: MJ
authors: Warren
mesh_terms: D005075:Biological Evolution; D003067:Coenzymes / Q000096:biosynthesis*; D004798:Enzymes / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D003067:Coenzymes; D004798:Enzymes