[Prevalence of antiretroviral drug genotypic resistance among HIV patients in Cuenca, Spain].
The aims were to assess the prevalence of resistances to antiretroviral drugs in HIV patients in the province of Cuenca and to determine the most frequently detected primary resistances. A total of 79 samples collected from April 2000 to July 2004 were analyzed. Resistance was detected using the genotypic technique VERSANTTM HIV1 (LiPA). Mutations more frequently found were M184V in the reverse transcriptase gene and V82A in the protease gene. The prevalence of primary resistances was 39.4%. Mutations more frequently detected were similar to those reported by other authors. The rate of primary resistance was higher than those found by other authors in Spain.
Rodriguez-Escudero
M J
MJ
Unidad de Microbiología (Servicio de Análisis Clínicos), Hospital Virgen de la Luz, Cuenca. mjrodrigueze@sescam.jccm.es
Prada de Medio
E
E
Rosa Herranz
C
C
Martinez Medina
M C
MC
Franquelo Gutierrez
R
R
D019943:Amino Acid Substitution; D019380:Anti-HIV Agents / Q000494:pharmacology*; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D017354:Point Mutation; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics; D013030:Spain / Q000453:epidemiology
D019380:Anti-HIV Agents; D012367:RNA, Viral; D054303:HIV Reverse Transcriptase; D016333:HIV Protease