title: Successful recovery after disseminated infection due to mycobacterium abscessus in a lung transplant patient: subcutaneous nodule as first manifestation--a case report.
abstract: Mycobacterium abscessus infection following lung transplantation (LT) has been described in a few cases. It is characterized by a variable initial location and subsequent course in this special risk group of patients, particularly those with cystic fibrosis (CF). Herein we have presented the case of a patient subjected to LT due to CF, who 1 year after transplantation developed a subcutaneous nodule produced by M abscessus, with subsequent hematogenous spread as well as bronchial and bone marrow involvement. Antecedents prior to LT included Staphylococcus aureus colonization and sputum positivity for Aspergillus fumigatus and Scedosporium apioespermum. Treatment with ciprofloxacin and linezolid was started on the basis of the antibiogram findings. The latter antibiotic was replaced by clarithromycin for 6 months. Two years later, the patient remains asymptomatic with respiratory function parameters in the normal range. The infected patient described herein was our only case with sepsis and multisystemic spread. The important mortality among such cases reported in the literature makes early diagnosis and treatment essential.
authors: Unidad de Trasplante Pulmonar, Hospital Universitario la Fe, Valencia, Spain. pila1460@separ.es
authors: P
authors: P
authors: Morales
authors: J A
authors: JA
authors: Ros
authors: M
authors: M
authors: Blanes
authors: D
authors: D
authors: Pérez-Enguix
authors: V
authors: V
authors: Saiz
authors: M
authors: M
authors: Santos
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000601:surgery; D006801:Humans; D000069349:Linezolid; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D009161:Mycobacterium / Q000145:classification / Q000302:isolation & purification; D009164:Mycobacterium Infections / Q000175:diagnosis*; D023303:Oxazolidinones / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000382:microbiology*; D013183:Sputum / Q000382:microbiology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D002939:Ciprofloxacin; D000069349:Linezolid