Liquid-phase microextraction with porous hollow fibers, a miniaturized and highly flexible format for liquid-liquid extraction.
Since 1999, substantial research has been devoted to the development of liquid-phase microextraction (LPME) based on porous hollow fibers. With this technology, target analytes are extracted from aqueous samples, through a thin supported liquid membrane (SLM) sustained in the pores in the wall of a porous hollow fiber, and further into a microL volume of acceptor solution placed inside the lumen of the hollow fiber. After extraction, the acceptor solution is directly subjected to a final chemical analysis by liquid chromatography (HPLC), gas chromatography (GC), capillary electrophoresis (CE), or mass spectrometry (MS). In this review, LPME will be discussed with focus on extraction principles, historical development, fundamental theory, and performance. Also, major applications have been compiled, and recent forefront developments will be discussed.
Pedersen-Bjergaard
Stig
S
School of Pharmacy, University of Oslo, PO Box 1068 Blindern, 0316 Oslo, Norway. stigpe@farmasi.uio.no
Rasmussen
Knut Einar
KE
D005591:Chemical Fractionation / Q000295:instrumentation / Q000379:methods*; D015283:Citalopram / Q000302:isolation & purification; D019075:Electrophoresis, Capillary; D008694:Methamphetamine / Q000302:isolation & purification; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations / Q000302:isolation & purification; D052617:Solid Phase Microextraction / Q000379:methods
D004364:Pharmaceutical Preparations; D015283:Citalopram; D008694:Methamphetamine