Predictors of renal involvement in patients with systemic lupus erythematosus.
From a cohort of 109 patients (105 females and 4 males) treated for systemic lupus erythematosus (SLE), 20 patients (18.3%) developed new episodes of lupus nephritis and 89 patients (81.7%) remained free of renal involvement during the follow-up period. The mean duration of follow up was 39.1 +/- 54.4 months. Clinical characteristics associated with developing lupus nephritis were a high systolic blood pressure (> or = 130 mmHg), photosensitivity, cutaneous vasculitis and gastrointestinal (GI) symptoms. Laboratory abnormalities associated with the development of lupus nephritis were hemoglobin < 10 mg/dl, hematocrit < 30%, blood urea nitrogen > 12 mg/dl, serum creatinine > 1.3 mg/dl, ESR > 60, the third component of complement (C3) level < 0.45 and positive antidsDNA antibody. After a multivariable analysis, only high systolic blood pressure, cutaneous vasculitis, hemoglobin < 10 mg/dl and serum creatinine > 1.3 mg/dl remained as statistically significant risk factors for developing lupus nephritis.
Satirapoj
Bancha
B
Department of Internal Medicine, Nopparat Rajathanee Hospital, Thailand. satirapoj@yahoo.com
Wongchinsri
Jeerapat
J
Youngprang
Nantana
N
Laonapaporn
Boonraksa
B
Chitrada
Thongdee
T
Lapkittichareonchai
Sumonkarn
S
Patumanon
Jayanton
J
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D008181:Lupus Nephritis / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D000974:Antibodies, Antinuclear