title: Julichrome Q6 glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp.
abstract: The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide ( 9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q 1.2 ( 7a), Q 1.5 ( 7b), and Q 3.5 ( 8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol ( 6a) and N-phenyl-beta-naphthylamine ( 10). The isomeric N-phenyl-alpha-naphthylamine ( 11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.
authors: Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
authors: Khaled A
authors: KA
authors: Shaaban
authors: Mohamed
authors: M
authors: Shaaban
authors: Iris
authors: I
authors: Grün-Wollny
authors: Armin
authors: A
authors: Maier
authors: Heinz H
authors: HH
authors: Fiebig
authors: Hartmut
authors: H
authors: Laatsch
mesh_terms: D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000737:chemistry; D015081:2-Naphthylamine / Q000031:analogs & derivatives / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002708:Chlorella / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D015942:Factor VIIa; D005965:Glucuronates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D011994:Recombinant Proteins; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D005965:Glucuronates; D009281:Naphthalenes; D011994:Recombinant Proteins; C524903:julichrome Q6 glucuronide; C011948:neozone; C005444:N-phenyl-1-naphthylamine; D015057:1-Naphthylamine; C103587:recombinant FVIIa; D015081:2-Naphthylamine; D015942:Factor VIIa