title: Peripapillary nerve fiber layer thickness measured by optical coherence tomography in patients with no light perception from long-standing nonglaucomatous optic neuropathies.
abstract: BACKGROUND
  The residual peripapillary retinal nerve fiber layer thickness (PRNFLT) corresponding to no light perception vision from long-standing nonglaucomatous optic neuropathies has not been documented. Such a benchmark would be useful information because PRNFLT is being used as an indicator of the visual recovery potential in patients with optic neuropathies.
  
  
  METHODS
  By means of optical coherence tomography (OCT) using a fast RNFL thickness protocol, we determined the PRNFLT in 8 patients with no light perception (NLP) for at least 1 year from acquired nonglaucomatous optic neuropathies. All patients underwent an assessment of visual acuity, color vision, visual field, pupillary reactions to light stimulation, and ophthalmoscopy.
  
  
  RESULTS
  Four of the 8 patients had a normal fellow eye. The average PRNFLT in the 4 normal eyes was 97.90 microm (range 94.82-100.89 microm), whereas the average PRNFLT in 8 of the 9 eyes with NLP was 45.42 microm (range 37.65-51.46 microm).
  
  
  CONCLUSIONS
  Eyes with long-standing NLP vision from nonglaucomatous optic neuropathies retain a residual PRNFLT of about 45 microm as measured by OCT. This should be taken into consideration when using PRNFLT to assess visual prognosis in patients with poor vision from various optic neuropathies.
authors: Neuro-Ophthalmology Unit (NRM), Wilmer Eye Institute, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA.
authors: Carmen K M
authors: CK
authors: Chan
authors: Neil R
authors: NR
authors: Miller
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012160:Retina / Q000473:pathology* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D015354:Vision, Low / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology