title: [Successful desensitization using cisplatin after carboplatin-associated hypersensitivity reactions in 3 cases with recurrent ovarian carcinoma].
abstract: The standard chemotherapy for ovarian carcinoma is paclitaxel and carboplatin concomitant therapy. This combination is so frequently administered that a carboplatin-associated hypersensitivity reaction may occur after long-term treatment. Recently, we experienced carboplatin-associated hypersensitivity reactions in three cases. They showed symptoms of tachycardia, chest tightness, and dyspnea. We report these cases that could be readministered platinum agent using the cisplatin desensitization method. This method was relatively safe and successful for patients with platinum-sensitive disease.
authors: Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine.
authors: Masayoshi
authors: M
authors: Hosaka
authors: Yasuhiko
authors: Y
authors: Ebina
authors: Masashi
authors: M
authors: Moriwaki
authors: Yoko
authors: Y
authors: Hara
authors: Naoto
authors: N
authors: Araki
authors: Yukiharu
authors: Y
authors: Todo
authors: Mahito
authors: M
authors: Takeda
authors: Hidemichi
authors: H
authors: Watari
authors: Noriaki
authors: N
authors: Sakuragi
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D016190:Carboplatin / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage*; D003888:Desensitization, Immunologic / Q000379:methods*; D004342:Drug Hypersensitivity / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin; D002945:Cisplatin