title: [Effect of chinese herbs in enhancing prednisone for treatment of refractory rheumatoid arthritis].
abstract: OBJECTIVE
  To investigate the Chinese herbal medicine in enhancing effect of prednisone for treatment of refractory rheumatoid arthritis (RA).
  
  
  METHODS
  One hundred and twenty patients with refraetory RA were assigned to two groups, the treated group was orally administered with Qingbi Tablet, a patent Chinese herbal preparation formulated based on the clearing heat and removing toxic substances principle, and the control group was treated with intramuscular injection of amethopterin (MTX), oral intake of voltaren 75 mg and hydroxychloroquine 0.2 g once a day. Besides prednisone was given to all patients orally, the initiating dosage used in the treated group was lesser than that in the control group. The clinical index, dosage and adverse reaction of prednisone were recorded every 2 weeks.
  
  
  RESULTS
  The curative effect evaluated by American College of Rheumatology (ACR) standard showed no statistical difference between the two groups (P > 0.05). Either clinical or laboratory indexes were improved significantly in both groups (P < 0.05), but the improvement in resting pain, patient's self-evaluation and doctor's evaluation in the treated group were better than those in the control group, showing statistical difference (P < 0.05). The 20-week total amount of prednisone used in the treated group was less than that in the control group (32,935 mg vs. 51,170 mg), while the dosage of prednisone used in various observation time points between the two groups was also significantly different respectively (P < 0.05), the former was less than the latter.
  
  
  CONCLUSIONS
  Chinese herbal medicine can enhance the effect of prednisone in patients of refractory RA and alleviate the adverse reactions of prednisone.
authors: Department of Rheumatism, The First Hospital Affiliated to Tianjin College of TCM, Tianjin. fengshiliuwei@163.com
authors: Wei
authors: W
authors: Liu
authors: Xiao-ya
authors: XY
authors: Liu
authors: Yi
authors: Y
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011241:Prednisone / Q000627:therapeutic use*; D013607:Tablets
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D013607:Tablets; C533456:qingbi; D011241:Prednisone