A new anti-HIV lupane acid from Gleditsia sinensis Lam.
A new lupane acid, 2beta-carboxyl,3beta-hydroxyl-norlupA (1)-20 (29)-en-28-oic acid (1), together with five known lupane acid derivatives (2-6), were isolated from the stings of Gleditsia sinensis Lam.. Their structures were elucidated on the basis of 1D and 2D NMR techniques. All these known compounds were isolated from this genus for the first time. The new compound 1 showed strong anti-HIV activity.
Li
Wan-Hua
WH
College of Life Science and Technology, Xi'an Jiao Tong University, China.
Zhang
Xiang-Ming
XM
Tian
Rong-Ren
RR
Zheng
Yong-Tang
YT
Zhao
Wen-Ming
WM
Qiu
Ming-Hua
MH
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D031501:Gleditsia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053978:Pentacyclic Triterpenes
D019380:Anti-HIV Agents; D014315:Triterpenes; C480546:lupane; D053978:Pentacyclic Triterpenes