Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies.
Testing of 12 pneumococcal strains with differing resistotypes [including tet(M) positive] showed that tigecycline, amoxicillin-clavulanate, imipenem, and ceftriaxone did not select for resistant clones after 50 sequential subcultures. By comparison, azithromycin, clarithromycin, clindamycin, telithromycin, levofloxacin, moxifloxacin, and gemifloxacin did show resistant clones. Tigecycline also yielded a low frequency of resistance in single-step tests compared to all beta-lactams, macrolides/ketolides, and quinolones tested.
Clark
Catherine L
CL
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA. pappelbaum@psu.edu.
Kosowska-Shick
Klaudia
K
Ednie
Lois M
LM
Appelbaum
Peter C
PC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology; D017963:Azithromycin / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology; D019818:Clavulanic Acid / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology; D000077735:Gemifloxacin; D015378:Imipenem / Q000494:pharmacology; D048628:Ketolides / Q000494:pharmacology; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests / Q000379:methods; D000077266:Moxifloxacin; D009287:Naphthyridines / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D048628:Ketolides; D009287:Naphthyridines; D011804:Quinolines; D019818:Clavulanic Acid; D002981:Clindamycin; D064704:Levofloxacin; D015378:Imipenem; D017963:Azithromycin; D015242:Ofloxacin; D017291:Clarithromycin; C106791:telithromycin; D000077735:Gemifloxacin; D000077266:Moxifloxacin