title: Neurogenesis in the postnatal human epileptic brain.
abstract: OBJECTIVE
  The normal adult human telencephalon does not reveal evidence of spontaneous neuronal migration and differentiation despite the robust germinal capacity of the subventricular zone (SVZ) astrocyte ribbon that contains neural stem cells. This might be because it is averse to accepting new neurons into an established neuronal network, probably representing an evolutionary acquisition to prevent the formation of anomalous neuronal circuits. Some forms of epilepsy, such as malformations of cortical development, are thought to be due to abnormal corticogenesis during the embryonic and early postnatal periods. The role of postnatal architectural reorganization and possibly postnatal neurogenesis in some forms of epilepsy in humans remains unknown. In this study the authors used resected specimens of epileptic brain to determine whether neurogenesis could occur in the diseased tissue.
  
  
  METHODS
  The authors studied freshly resected brain tissue obtained in 47 patients who underwent neurosurgical procedures and four autopsies. Forty-four samples were harvested in patients who underwent resection for the treatment of pharmacoresistant epilepsy.
  
  
  RESULTS
  Using organotypic brain slice preparations cultured with 5-bromodeoxyuridine (a marker for cell proliferation), immunohistochemistry, and cell trackers, the authors demonstrate the presence of spontaneous cell proliferation, migration, and neuronal differentiation in the adult human telencephalon that starts in the SVZ and progresses to the adjacent white matter and neocortex in human neocortical pathological structures associated with epilepsy. No cell migration or neuronal differentiation was found in the control group.
  
  
  CONCLUSIONS
  The presence of spontaneous neurogenesis associated with some forms of human neocortical epilepsy may represent an erroneous and maladaptive mechanism for neuronal circuitry repair, or it may be an intrinsic part of the pathogenic process.
authors: Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio 44195, USA. gonzalj1@ccf.org
authors: Jorge A
authors: JA
authors: González-Martínez
authors: William E
authors: WE
authors: Bingaman
authors: Steven A
authors: SA
authors: Toms
authors: Imad M
authors: IM
authors: Najm
mesh_terms: D000293:Adolescent; D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology* / Q000502:physiology*; D016022:Case-Control Studies; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009474:Neurons / Q000502:physiology; D013687:Telencephalon / Q000473:pathology*