title: An investigation into the tether length and substitution pattern of arene-substituted complexes for asymmetric transfer hydrogenation of ketones.
abstract: A series of Ru(II) catalysts were prepared and tested in the asymmetric transfer hydrogenation of ketones. The catalyst containing a "4-carbon" tether gave the fastest rates of ketone reduction. This is due to both increased rate of regeneration of hydride "Ru-H" and increased rate of ketone reduction. Several classes of ketone were reduced in enantiomeric excesses of up to 97%. Substituents on the arene ring of the catalyst influence the reaction rate and enantioselectivity.
authors: Asymmetric Catalysis Group, Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
authors: Fung K
authors: FK
authors: Cheung
authors: Changxue
authors: C
authors: Lin
authors: Franco
authors: F
authors: Minissi
authors: Adriana Lorente
authors: AL
authors: Crivillé
authors: Mark A
authors: MA
authors: Graham
authors: David J
authors: DJ
authors: Fox
authors: Martin
authors: M
authors: Wills