title: Novel drug resistance pattern associated with the mutations K70G and M184V in human immunodeficiency virus type 1 reverse transcriptase.
abstract: We describe an unusual pathway of human immunodeficiency virus type 1 reverse transcriptase resistance during therapy with tenofovir-emtricitabine, characterized initially by the mutations K70E and M184V and later by K70G and M184V, with the two mutations coexisting on the same viral genome. Phenotypic resistance to lamivudine, emtricitabine, abacavir, didanosine, and tenofovir was observed, whereas susceptibility to zidovudine and stavudine was preserved.
authors: Department of Virology, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom.
authors: D
authors: D
authors: Bradshaw
authors: S
authors: S
authors: Malik
authors: C
authors: C
authors: Booth
authors: M
authors: M
authors: Van Houtte
authors: T
authors: T
authors: Pattery
authors: A
authors: A
authors: Waters
authors: J
authors: J
authors: Ainsworth
authors: A M
authors: AM
authors: Geretti
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D019943:Amino Acid Substitution / Q000235:genetics*; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000494:pharmacology; D016049:Didanosine / Q000494:pharmacology; D015224:Dideoxynucleosides / Q000494:pharmacology; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics*; D000068679:Emtricitabine; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D006801:Humans; D019259:Lamivudine / Q000494:pharmacology; D008969:Molecular Sequence Data; D009154:Mutation; D063065:Organophosphonates / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*; D018119:Stavudine / Q000494:pharmacology; D000068698:Tenofovir; D015215:Zidovudine / Q000494:pharmacology; D000099227:Abacavir
chemical_list: D000225:Adenine; D003841:Deoxycytidine; D016049:Didanosine; D015224:Dideoxynucleosides; D000068679:Emtricitabine; D054303:HIV Reverse Transcriptase; D019259:Lamivudine; D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D018119:Stavudine; D000068698:Tenofovir; D015215:Zidovudine; D000099227:Abacavir; C514824:reverse transcriptase, Human immunodeficiency virus 1