Cutting and stitching: the cross-linking of peptidoglycan in the assembly of the bacterial cell wall.
The machinery responsible for bacterial cell wall synthesis has proven to be an invaluable antibiotic target. Nearly 80 years after the discovery of penicillin, some of the mysteries surrounding this process are finally being unraveled.
Buynak
John D
JD
Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, USA. jbuynak@smu.edu
D001419:Bacteria / Q000201:enzymology / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D002473:Cell Wall / Q000737:chemistry / Q000378:metabolism; D046915:Penicillin-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D010406:Penicillins / Q000737:chemistry / Q000378:metabolism*; D010457:Peptidoglycan / Q000737:chemistry* / Q000378:metabolism*
D001426:Bacterial Proteins; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D010457:Peptidoglycan