Mobility and immobility of chromatin in transcription and genome stability.
Chromatin is increasingly recognized as a highly dynamic entity. Chromosome sites in lower and higher eukaryotes undergo frequent, rapid, and constrained local motion and occasional slow, long-range movements. Recent observations have revealed some of the functional relevance of chromatin mobility. Paradoxically, both the mobility and immobility of chromatin appear to have functional consequences: Local diffusional motion of chromatin is important in gene regulation, but global chromatin immobility plays a key role in maintenance of genomic stability.
Soutoglou
Evi
E
National Cancer Institute, NIH, Bethesda, MD 20892, United States.
Misteli
Tom
T
D000818:Animals; D002467:Cell Nucleus / Q000502:physiology*; D002843:Chromatin / Q000378:metabolism*; D045584:Chromosome Positioning; D002875:Chromosomes / Q000502:physiology*; D005786:Gene Expression Regulation; D042822:Genomic Instability; D006801:Humans; D008954:Models, Biological; D014158:Transcription, Genetic
D002843:Chromatin