title: Evaluation of a shock wave induced cavitation activity both in vitro and in vivo.
abstract: This study evaluated the cavitation activity induced by shock wave (SW) pulses, both in vitro and in vivo, based on the area measurements of echogenic regions observed in B-mode ultrasound images. Residual cavitation bubble clouds induced by SW pulses were detected as echogenic regions in B-mode images. The temporal evolution of residual bubble clouds, generated by SWs with varying lithotripter charging voltage and pulse repetition frequency (PRF), was analyzed by measuring the time-varying behaviors of the echogenic region areas recorded in B-mode images. The results showed that (1) the area of SW-induced echogenic regions enlarged with increased SW pulse number; (2) echogenic regions in the B-mode images dissipated gradually after ceasing the SWs, which indicated the dissolution of the cavitation bubbles; and (3) larger echogenic regions were generated with higher charging voltage or PRF.
authors: Key Laboratory of Modern Acoustics and Institute of Acoustics, Nanjing University, Nanjing, Jiangsu, 210093, People's Republic of China. juantutu@gmail.com
authors: Juan
authors: J
authors: Tu
authors: Thomas J
authors: TJ
authors: Matula
authors: Michael R
authors: MR
authors: Bailey
authors: Lawrence A
authors: LA
authors: Crum
mesh_terms: D001822:Body Burden; D003198:Computer Simulation; D019220:High-Energy Shock Waves / Q000627:therapeutic use*; D006801:Humans; D008096:Lithotripsy / Q000379:methods*; D008954:Models, Biological; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D012062:Relative Biological Effectiveness; D014464:Ultrasonic Therapy / Q000379:methods*