[Study on the risk factors for optic nerve invasion in 381 cases of retinoblastoma].
OBJECTIVE
To investigate the clinical and pathologic outcomes of a large group of retinoblastoma (RB) cases to ascertain the risk factors of RB optic nerve invasion.


METHODS
In this paper, we summarized the clinical and pathologic data of 381 retinoblastoma cases in Beijing Tongren Hospital observed from 1990 to 2002. Statistical analyses were performed on the sex, age, unilateral or bilateral cases, length of symptoms, clinical situation, stage, histological type and the degree of optic nerve invasion.


RESULTS
The degree of RB optic nerve invasion was closely correlated to clinical stage and tumor differentiation.


CONCLUSIONS
Avoiding the risk factors of RB optic nerve invasion is very important for the prognosis of RB.
Ren
Ruo-Jin
RJ
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital University of Medical Sciences, Beijing 100730, China.
Li
Bin
B
Li
Liao-Qing
LQ
Sun
Xian-Li
XL
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009367:Neoplasm Staging; D009900:Optic Nerve / Q000473:pathology*; D011379:Prognosis; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D012175:Retinoblastoma / Q000175:diagnosis / Q000473:pathology*; D012307:Risk Factors