Chitosan and its derivatives for tissue engineering applications.
Tissue engineering is an important therapeutic strategy for present and future medicine. Recently, functional biomaterial researches have been directed towards the development of improved scaffolds for regenerative medicine. Chitosan is a natural polymer from renewable resources, obtained from shell of shellfish, and the wastes of the seafood industry. It has novel properties such as biocompatibility, biodegradability, antibacterial, and wound-healing activity. Furthermore, recent studies suggested that chitosan and its derivatives are promising candidates as a supporting material for tissue engineering applications owing to their porous structure, gel forming properties, ease of chemical modification, high affinity to in vivo macromolecules, and so on. In this review, we focus on the various types of chitosan derivatives and their use in various tissue engineering applications namely, skin, bone, cartilage, liver, nerve and blood vessel.
Kim
In-Yong
IY
School of Agricultural Biotechnology, Seoul National University, Seoul 151-921, South Korea.
Seo
Seog-Jin
SJ
Moon
Hyun-Seuk
HS
Yoo
Mi-Kyong
MK
Park
In-Young
IY
Kim
Bom-Chol
BC
Cho
Chong-Su
CS
D000818:Animals; D001187:Artificial Organs; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
D048271:Chitosan