Reversible dementia and corresponding CSF alterations due to intraspinal lumbosacral metastasis of a prostate carcinoma.
We report, for the first time, how intraspinal carcinoma metastasis can cause reversible dementia accompanied by distinct cerebrospinal fluid (CSF) alterations. A 73-year-old male patient who suffered from rapidly progressive dementia and gait disturbance showed marked abnormalities of CSF tau protein, amyloid beta(1-42), and prostate-specific antigen. A lumbosacral, intraspinal metastasis from a prostate carcinoma was found, and after microsurgical removal, CSF alterations normalized and the clinical symptoms regressed. This case illustrates how malignant tumors can disturb brain function via indirect mechanisms.
Winkler
F
F
Department of Neurology, Ludwig-Maximilians University, Munich, Germany. frank.winkler@med.uni-muenchen.de
Gschwendtner
A
A
Theisen
D
D
Peraud
A
A
Straube
A
A
D000368:Aged; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid; D001923:Brain Chemistry / Q000502:physiology; D001928:Brain Diseases, Metabolic / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000503:physiopathology; D002277:Carcinoma / Q000556:secondary*; D002556:Cerebrospinal Fluid Proteins / Q000378:metabolism*; D019299:Decompression, Surgical; D003704:Dementia / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D008297:Male; D019635:Neurosurgical Procedures; D017430:Prostate-Specific Antigen / Q000134:cerebrospinal fluid; D011471:Prostatic Neoplasms / Q000473:pathology*; D012074:Remission Induction; D013120:Spinal Cord Neoplasms / Q000556:secondary*; D016896:Treatment Outcome; D016875:tau Proteins / Q000134:cerebrospinal fluid
D016229:Amyloid beta-Peptides; D014408:Biomarkers, Tumor; D002556:Cerebrospinal Fluid Proteins; D016875:tau Proteins; D017430:Prostate-Specific Antigen