title: Development of scotopic visual thresholds in retinopathy of prematurity.
abstract: OBJECTIVE
  To test the hypothesis that the late-maturing parafoveal rod photoreceptors are more vulnerable than peripheral rods to the effects of retinopathy of prematurity (ROP).
  
  
  METHODS
  Twenty-four infants with a history of preterm birth (gestational age at birth </=31 weeks) participated in a longitudinal study: 12 had mild ROP that resolved without treatment, and 12 had never had ROP. Thresholds for detecting stimuli (2 degrees diameter, 50 ms duration) presented 10 degrees (parafoveal) and 30 degrees (peripheral) from a central fixation target were estimated by using a preferential-looking
  
  
  METHODS
  At each visit, thresholds at both sites were obtained in random order. Thresholds of the preterm subjects were compared with those of previously reported term infants.
  
  
  RESULTS
  The course of threshold maturation in subjects with ROP was significantly prolonged (P </= 0.01) compared with those who had never had ROP and with term-born control subjects. On average, parafoveal thresholds in subjects with ROP reached the adult level at a median age of 12 (range, 6-18) months, and peripheral thresholds reached the adult level at 9 (range, 5-12) months. Median thresholds in subjects who had never had ROP reached adult levels at both sites by approximately 7 months.
  
  
  CONCLUSIONS
  The slower development of parafoveal compared with peripheral thresholds in subjects with a history of ROP is evidence that the late-maturing parafoveal rods are more affected by the ROP disease process.
authors: Department of Ophthalmology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors: Amber M
authors: AM
authors: Barnaby
authors: Ronald M
authors: RM
authors: Hansen
authors: Anne
authors: A
authors: Moskowitz
authors: Anne B
authors: AB
authors: Fulton
mesh_terms: D000375:Aging / Q000502:physiology; D001724:Birth Weight; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D017948:Retinal Rod Photoreceptor Cells / Q000502:physiology*; D012178:Retinopathy of Prematurity / Q000503:physiopathology*; D012684:Sensory Thresholds / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*