Comparison of high-frequency chest wall oscillation with differing waveforms for airway clearance in cystic fibrosis.
BACKGROUND
High-frequency chest wall oscillation (HFCWO) is commonly used by cystic fibrosis (CF) patients for airway clearance. The primary objective of this study was to determine whether the use of a newer HFCWO device that generates oscillations with a triangular waveform results in greater sputum production than a commonly used device that generates oscillations with a sine waveform.


METHODS
This was a controlled, randomized, double-blind, crossover study. Fifteen clinically stable, adult CF patients participated. Patients performed airway clearance with each device once and at matched oscillation frequencies and pressures. All sputum produced during each session was collected. Patients completed pulmonary function tests before and after each session, and rated the comfort of the two devices.


RESULTS
Mean sputum wet and dry weight produced during sine waveform and triangular waveform HFCWO sessions did not differ (p = 0.11 and p = 0.2, respectively). Mean changes in FEV(1) and FVC following HFCWO therapy were also comparable (p = 0.21 and p = 0.56, respectively). However, there was a significant reduction in air trapping by residual volume/total lung capacity ratio following triangular waveform HFCWO (p = 0.01). In addition, in vitro cough transportability was 10.6% greater following therapy with the triangular waveform device (p = 0.05). Patients perceived the two devices as equally comfortable (p = 0.8).


CONCLUSIONS
Single-session sputum production is comparable with sine and triangular waveform HFCWO devices. Longer term comparisons are needed to determine whether sustained use of the devices results in clinically important differences in outcomes.
Kempainen
Robert R
RR
Minnesota Cystic Fibrosis Center, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN, USA.
Williams
Cynthia B
CB
Hazelwood
Ann
A
Rubin
Bruce K
BK
Milla
Carlos E
CE
D000328:Adult; D035641:Chest Wall Oscillation / Q000379:methods*; D018592:Cross-Over Studies; D003550:Cystic Fibrosis / Q000628:therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D012115:Residual Volume; D012212:Rheology; D013183:Sputum / Q000502:physiology; D014109:Total Lung Capacity