In vivo observations of a case of chlorpromazine deposits in the cornea using an HRT II Rostock corneal module.
OBJECTIVE
In vivo study of corneal deposits in a patient receiving chlorpromazine therapy was done by using a confocal microscope, the HRT II Rostock corneal module (RCM).


METHODS
A 23-year-old woman who had been on chlorpromazine therapy for 5 years complained of bilateral photophobia and was referred to our clinic. She had suffered from light sensitivity for 4 years.


RESULTS
Slit-lamp microscopy revealed white deposits, particularly in the layers of the endothelium and Descemet membrane, which were concentrated in the center of both corneas. Deposition of many white granules was observed in the superficial subepithelial stroma of the cornea by HRT II RCM. Granular deposits were observed at the center of most cells in the corneal endothelium.


CONCLUSIONS
The HRT II RCM could clearly detect deposits in the corneal endothelium, as well as in other regions such as the corneal epithelium and stroma.
Toshida
Hiroshi
H
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan. toshida@med.juntendo.ac.jp
Uesugi
Yuko
Y
Ebihara
Nobuyuki
N
Murakami
Akira
A
D000328:Adult; D002746:Chlorpromazine / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D003318:Corneal Opacity / Q000139:chemically induced* / Q000175:diagnosis*; D018492:Dopamine Antagonists / Q000009:adverse effects*; D005260:Female; D006801:Humans; D018613:Microscopy, Confocal; D012559:Schizophrenia / Q000188:drug therapy
D018492:Dopamine Antagonists; D002746:Chlorpromazine