[An experimental organ model for magnetic resonance imaging].
The investigation of reperfusion of organs after an ischaemic phase is of great interest in transplantation medicine. This work presents an experimental organ model for the examination of isolated canine livers by means of magnetic resonance imaging in reperfusion experiments. The perfusion of the organs inside a perfusate container in the scanner's head coil was performed with approximately physiological conditions for 1.5 hours. The pumps for the perfusate circulation were installed outside the scanner's room, where oxygenation and heating of the perfusate was also performed. In the MR examinations, T1- and T2-weighted sequences could be used to display the morphology of the organs and the spatial perfusion distribution after administration of contrast media. The images revealed oedema development during reperfusion and an inhomogenous perfusion distribution. Thus, the model allows for the non-invasive investigation of morphology and perfusion distribution in isolated reperfused organs.
Risse
Frank
F
Medizinische Physik in der Radiologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
Boese
Jan M
JM
Hess
Thomas
T
Mory
Martin
M
Schäfer
Michael
M
Gebhard
Martha-Maria
MM
Schad
Lothar R
LR
D003287:Contrast Media; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000033:anatomy & histology; D008102:Liver Circulation; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008953:Models, Anatomic; D015424:Reperfusion / Q000379:methods
D003287:Contrast Media