title: [Sclerosing Sertoli cell tumor of the testis: a rare tumor. Case report and review of the literature on the subtypes of Sertoli-cell tumor].
abstract: Sertoli cell tumors of the testis are extremely rare (0.4-1.5% of all testicular neoplasms) and have a heterogeneous pathology. Histopathologically classic, large cell calcifying and sclerosing subtypes are differentiated.Up to now, 14 cases of sclerosing Sertoli cell tumor are known. This article presents a new case and compares the three subtypes. The subtypes differ in particular in age of onset, malignant potential, prognosis, and therapy. While no cases of sclerosing Sertoli cell tumor with a malignant course have been reported, both other subtypes have been found to be potentially malignant. In the case of malignancy the prognosis is very poor, and it is difficult to select the best treatment because there is so little experience with this type of tumor. Once the diagnosis of a Sertoli cell tumor has been confirmed, exact determination of the histological subtype is essential to allow appropriate risk-adapted therapy. The various histological subtypes are presented with the clinical features, prognosis and treatment of each.
authors: Urologische Abteilung, Bundeswehrkrankenhaus, Oberer Eselsberg 40, 89081, Ulm, Germany. MarenWerther@gmx.de
authors: M
authors: M
authors: Werther
authors: H-U
authors: HU
authors: Schmelz
authors: M
authors: M
authors: Schwerer
authors: C
authors: C
authors: Sparwasser
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D001706:Biopsy; D003937:Diagnosis, Differential; D005235:Fatty Liver, Alcoholic / Q000097:blood; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D012598:Sclerosis; D012707:Sertoli Cell Tumor / Q000175:diagnosis* / Q000473:pathology; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013737:Testis / Q000473:pathology; D014463:Ultrasonography; D000509:alpha-Fetoproteins
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins