title: Breast cancers: noninvasive method of preoperative localization with three-dimensional US and surface contour mapping.
abstract: Formal ethical approval was granted by the local research ethics committee; all participants gave written consent. The purpose of the study was to prospectively evaluate the feasibility of a noninvasive method of breast tumor localization in 25 participants, based on the coregistration of three-dimensional (3D) ultrasonographic (US) data with surface contour data obtained by using a 3D laser camera. The tumor is segmented from the US data, and a surface-rendered 3D image of the tumor, in relation to the breast surface contour, is produced. From a personal computer in the operating room, the surgeon can dynamically view a 3D image of the tumor within the breast. This noninvasive method was equivalent to conventional techniques in 18 of 25 patients but was less successful in larger-breasted patients. In selected patients, this localization method could provide an alternative to conventional invasive techniques and can offer both spatial localization and tumor morphology.
authors: Department of Radiology, Cambridge University, Hills Road, Cambridge, UK. cjcc2@ukonline.co.uk
authors: Charlotte J C
authors: CJ
authors: Cash
authors: Charlotte E
authors: CE
authors: Coles
authors: Graham M
authors: GM
authors: Treece
authors: Anand D
authors: AD
authors: Purushotham
authors: Peter
authors: P
authors: Britton
authors: Ruchi
authors: R
authors: Sinnatamby
authors: Andrew H
authors: AH
authors: Gee
authors: Richard W
authors: RW
authors: Prager
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007834:Lasers; D008408:Mastectomy; D008875:Middle Aged; D010865:Pilot Projects; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D016217:Ultrasonography, Mammary / Q000379:methods*