title: The renaissance of H/D exchange.
abstract: The increasing demand for stable isotopically labeled compounds has led to an increased interest in H/D-exchange reactions at carbon centers. Today deuterium-labeled compounds are used as internal standards in mass spectrometry or to help elucidate mechanistic theories. Access to these deuterated compounds takes place significantly more efficiently and more cost effectively by exchange of hydrogen by deuterium in the target molecule than by classical synthesis. This Review will concentrate on the preparative application of the H/D-exchange reaction in the preparation of deuterium-labeled compounds. Advances over the last ten years are brought together and critically evaluated.
authors: Isotope Chemistry Metabolite Synthesis (ICMS), Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926 Frankfurt am Main, Germany. jens.atzrodt@sanofi-aventis.com
authors: Jens
authors: J
authors: Atzrodt
authors: Volker
authors: V
authors: Derdau
authors: Thorsten
authors: T
authors: Fey
authors: Jochen
authors: J
authors: Zimmermann
mesh_terms: D002384:Catalysis; D041961:Deuterium Exchange Measurement / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008670:Metals / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D008670:Metals