[Effects of Porphyromonas gingivalis lipopolysaccharide on collagen phagocytosis by human periodontal ligament fibroblasts].
OBJECTIVE
To investigate the effects of Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) on collagen phagocytosis of human periodontal ligament fibroblasts (hPDLF).


METHODS
Fluorescence localization and flow cytometry was used to test the collagen phygocytosis of hPDLF stimulated by the various concentration of LPS for 48 hours in vitro.


RESULTS
The collagen phygocytosis of hPDLF was increased significantly by 0.1 microg/mL LPS (P < 0.05).


CONCLUSIONS
This study indicates that P. gingivalis LPS may enhance the degradation of collagen by stimulating the phagocytic activity of the hPDLF in periodontitis.
Fang
Chang-yun
CY
Stomatological Department, Xiangya Hospital of Central South University, Changsha 410008, China.
Su
Zheng
Z
Chen
Lei
L
Fan
Ming-wen
MW
Jian
Xin-chun
XC
Chen
Zhi
Z
D003094:Collagen; D005347:Fibroblasts; D005881:Gingiva; D006801:Humans; D015850:Interleukin-6; D008070:Lipopolysaccharides; D010513:Periodontal Ligament; D010518:Periodontitis; D010587:Phagocytosis; D016966:Porphyromonas gingivalis
D015850:Interleukin-6; D008070:Lipopolysaccharides; D003094:Collagen