Polymorphonuclear leukocyte function in type-2 diabetes mellitus patients and its correlation with glycaemic control.
Infection is an important cause of morbidity and mortality in diabetic patients. Chronic hyperglycaemia impairs host defense mechanism such as cell mediated immunity, polymorphonuclear leukocyte (PMNL) function, antibody formation etc. PMNL serves as bodies first line of defense against various infections. The present study was undertaken to establish a correlation between impaired PMNL function, blood glucose levels and its improvement with good glycaemic control with glibenclamide and glimepiride, with special reference to parameters such as respiratory burst and O2(-) and H2O2 production by diabetic neutrophils.
Bhattacharya
Swapan Kumar
SK
Department of Pharmacology, BPKIHS, Dharan, Nepal. skbnpl@yahoo.co.in
Shastri
Sunita
S
Mahajan
Prabha
P
Madhu
Sri Venkata
SV
Tripathi
Ashoke Kumar
AK
Rauniar
Gajendra Prasad
GP
Das
Balbhadra Prasad
BP
Paudel
Keshab Raj
KR
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects; D002908:Chronic Disease; D048909:Diabetes Complications / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology* / Q000517:prevention & control; D005260:Female; D005905:Glyburide / Q000627:therapeutic use; D006442:Glycated Hemoglobin; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D016897:Respiratory Burst; D013453:Sulfonylurea Compounds / Q000627:therapeutic use
D001786:Blood Glucose; D005905:Glyburide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; C057619:glimepiride