title: Parotid localized Castleman's disease and HHV-8 infection: a case report.
abstract: Castleman's disease (CD) is an unusual massive proliferation of lymphoid tissue distinct in two clinical forms, localized and multicentric. The multicentric form has been related to human herpesvirus 8 (HHV-8), especially in HIV-infected patients, whereas the localized form of CD is still unrelated to viral pathogens. We report a case of a HIV-negative 16-year-old male referred to our hospital with a 12-month history of a painless swelling in his right parotid region. A parotidectomy was performed, and histological analysis evidenced a localized CD. The search for HHV-8 revealed an active virus infection. The patient was commenced on corticosteroid therapy and a follow-up was performed every 6 months. The patient was commenced on corticosteroid therapy and there has been no recurrence after 24 months. The authors report a case of localized parotid CD in a patient with evidence of an active HHV-8 infection. The results of this study does for the first time suggest an association between HHV-8 and localized CD in HIV-negative subjects.
authors: Section of Microbiology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy.
authors: Elisabetta
authors: E
authors: Caselli
authors: Davide
authors: D
authors: Padovani
authors: Roberto
authors: R
authors: Di Carlo
authors: Enrico
authors: E
authors: Grandi
authors: Monica
authors: M
authors: Galvan
authors: Enzo
authors: E
authors: Cassai
authors: Antonio
authors: A
authors: Pastore
mesh_terms: D000293:Adolescent; D005871:Castleman Disease / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology*; D006566:Herpesviridae Infections / Q000150:complications*; D019288:Herpesvirus 8, Human; D006801:Humans; D008297:Male; D010305:Parotid Diseases / Q000000981:diagnostic imaging / Q000821:virology*; D014057:Tomography, X-Ray Computed