title: A topology optimization based model of bone adaptation.
abstract: A novel topology optimization model based on homogenization methods was developed for predicting bone density distribution and anisotropy, assuming the bone structure to be a self-optimizing biological material which maximizes its own structural stiffness. The feasibility and efficiency of this method were tested on a 2D model for a proximal femur under single and multiple loading conditions. The main aim was to compute homogenized optimal designs using an optimal laminated microstructure. The computational results showed that high bone density levels are distributed along the diaphysis and form arching struts within the femoral head. The pattern of bone density distribution and the anisotropic bone behavior predicted by the model in the multiple load case were both in good agreement with the structural architecture and bone density distribution occurring in natural femora. This approach provides a novel means of understanding the remodeling processes involved in fracture repair and the treatment of bone diseases.
authors: CNRS-USR 2164 Laboratoire d'Aérodynamique et Biomécanique du Mouvement, Marseille Cedex 9, France. jean-marie.rossi@ec-marseille.fr
authors: Jean-Marie
authors: JM
authors: Rossi
authors: Sylvie
authors: S
authors: Wendling-Mansuy
mesh_terms: D016880:Anisotropy; D001846:Bone Development / Q000502:physiology*; D002113:Calcification, Physiologic / Q000502:physiology*; D003198:Computer Simulation; D005269:Femur / Q000502:physiology*; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological