Common variable immunodeficiency syndrome associated with epidermodysplasia verruciformis.
We report the association of common variable immunodeficiency syndrome with epidermodysplasia verruciformis (EV) manifesting as flat warts and squamous cell carcinomas in a 21-year-old Hispanic woman. Human papillomavirus (HPV) typing by polymerase chain reaction using an EV-HPV primer system, cloning, and sequencing detected HPV-8 and HPV-23 DNAs in the biopsy sample. Our case is the second reported case of common variable immunodeficiency syndrome associated with EV.
Vu
Jenny
J
Department of Dermatology, University of Texas MD Anderson Cancer Center and Medical School, Houston, Texas 77030-4009, USA. jvu@mdanderson.org
Wallace
Genevieve R
GR
Singh
Rajendra
R
Diwan
Hafeez
H
Prieto
Victor
V
Rady
Peter
P
Tyring
Stephen
S
Duvic
Madeleine
M
D000328:Adult; D052686:Betapapillomavirus / Q000235:genetics / Q000302:isolation & purification*; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000473:pathology / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D004819:Epidermodysplasia Verruciformis / Q000150:complications* / Q000473:pathology / Q000821:virology; D005260:Female; D006801:Humans; D009061:Mouth Mucosa / Q000473:pathology; D016133:Polymerase Chain Reaction; D012867:Skin / Q000473:pathology
D004279:DNA, Viral