title: Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder.
abstract: Brain-derived neurotrophic factor val66met polymorphism has been implicated in the pathophysiology of bipolar disorder. We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor val66met polymorphism using H-magnetic resonance spectroscopy. Absolute N-acetyl-aspartate, phosphocreatine+creatine (PCr+Cr), choline-containing compounds, myo-inositol, and glutamate levels were measured. Bipolar disorder met-carriers had lower PCr+Cr levels than bipolar disorder val/val patients, and bipolar disorder val/val patients had higher PCr+Cr levels than val/val healthy controls. These results indicate that bipolar disorder met-carriers have abnormal energy metabolism in the left dorsolateral prefrontal cortex.
authors: Department of Psychiatry, Psychiatric Genetics Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
authors: Benicio N
authors: BN
authors: Frey
authors: Consuelo
authors: C
authors: Walss-Bass
authors: Jeffrey A
authors: JA
authors: Stanley
authors: Fabiano G
authors: FG
authors: Nery
authors: Koji
authors: K
authors: Matsuo
authors: Mark A
authors: MA
authors: Nicoletti
authors: John P
authors: JP
authors: Hatch
authors: Charles L
authors: CL
authors: Bowden
authors: Michael A
authors: MA
authors: Escamilla
authors: Jair C
authors: JC
authors: Soares
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics / Q000502:physiology; D001224:Aspartic Acid / Q000378:metabolism; D001714:Bipolar Disorder / Q000235:genetics* / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics* / Q000502:physiology*; D003401:Creatine / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008715:Methionine / Q000502:physiology; D010725:Phosphocreatine / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000502:physiology*; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D014633:Valine / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D010725:Phosphocreatine; D001224:Aspartic Acid; D008715:Methionine; D014633:Valine; D003401:Creatine