Occurrence of highly fluoroquinolone-resistant and methicillin-resistant Staphylococcus aureus in domestic animals.
We describe phenotypic and genotypic analyses carried out on multidrug-resistant Staphylococcus aureus isolated from domestic animals. The sequence type ST239 methicillin-resistant Staphylococcus aureus isolated from dogs were highly resistant to fluoroquinolones, and new combinations of GyrA and GrlA mutations were identified. These findings are consistent with a role for animal carriage in the dissemination of important human pathogens in the community.
Lin
Ann E
AE
Department of Microbiology and Immunology, Life Sciences Centre, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Davies
Julian E
JE
D000818:Animals; D000829:Animals, Domestic; D000890:Anti-Infective Agents / Q000494:pharmacology; D002371:Cat Diseases / Q000382:microbiology; D002415:Cats; D002645:Chickens; D002939:Ciprofloxacin / Q000494:pharmacology; D017714:Community-Acquired Infections / Q000382:microbiology; D027081:DNA Gyrase / Q000235:genetics; D004197:Disease Reservoirs / Q000382:microbiology / Q000662:veterinary; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D016106:Methicillin Resistance; D010802:Phylogeny; D011201:Poultry Diseases / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D015047:Zoonoses / Q000382:microbiology
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D027081:DNA Gyrase