title: Beneficial effects of cardiac rehabilitation and exercise after percutaneous coronary intervention on hsCRP and inflammatory cytokines in CAD patients.
abstract: Recent studies showed that tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), as well as high-sensitive C-reactive protein (hsCRP) levels are predictive factors of cardiovascular risk. However, the effect of cardiac rehabilitation (CR) intervention in coronary artery disease (CAD) patients on these factors is not known. The aim of this study was to evaluate the effects of CR and exercise on hsCRP and inflammatory cytokine levels in patients with CAD after percutaneous coronary intervention (PCI). CAD patients who underwent PCI were divided into a CR and exercise group (CRE, n = 29) or a control group (CON, n = 10). CR and exercise consisted of 6 weeks supervised exercise training and 8 weeks home-based, self-managed exercise. Compared to pre-experimental levels, TNF-alpha (by 20.4%; p = 0.006) and IL-6 (by 49.0%; p < 0.0001), as well as hsCRP (by 59.4%; p < 0.0001), were markedly decreased after CR and exercise in CAD patients but not in control group, except for IL-6 (by 41.6%; p = 0.001). However, there was no significant alteration of adiposity-related variables such as BMI, percent body fat, and waist circumferences, in both groups. We suggest that CR and exercise in CAD patients after PCI induce significant reduction in hsCRP and inflammatory cytokines (TNF-alpha and IL-6), and marked increase in exercise tolerance and capacity.
authors: Department of Rehabilitation Medicine, College of Medicine, Inje University, Seoul, Republic of Korea.
authors: Young-Joo
authors: YJ
authors: Kim
authors: Young-Oh
authors: YO
authors: Shin
authors: Jun-Sang
authors: JS
authors: Bae
authors: Jeong-Beom
authors: JB
authors: Lee
authors: Joo-Hyun
authors: JH
authors: Ham
authors: Youn-Jung
authors: YJ
authors: Son
authors: Jung-Kyu
authors: JK
authors: Kim
authors: Chul
authors: C
authors: Kim
authors: Byoung-Kwon
authors: BK
authors: Lee
authors: Jae-Keun
authors: JK
authors: Oh
authors: Timothy
authors: T
authors: Othman
authors: Young-Ki
authors: YK
authors: Min
authors: Hun-Mo
authors: HM
authors: Yang
mesh_terms: D050154:Adiposity / Q000502:physiology; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000503:physiopathology* / Q000534:rehabilitation*; D016207:Cytokines / Q000378:metabolism*; D005080:Exercise Test; D005081:Exercise Therapy; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006334:Heart Function Tests; D006801:Humans; D007958:Leukocyte Count; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; D005340:Fibrinogen; D002097:C-Reactive Protein