title: [Study on the risk factors for optic nerve invasion in 381 cases of retinoblastoma].
abstract: OBJECTIVE
  To investigate the clinical and pathologic outcomes of a large group of retinoblastoma (RB) cases to ascertain the risk factors of RB optic nerve invasion.
  
  
  METHODS
  In this paper, we summarized the clinical and pathologic data of 381 retinoblastoma cases in Beijing Tongren Hospital observed from 1990 to 2002. Statistical analyses were performed on the sex, age, unilateral or bilateral cases, length of symptoms, clinical situation, stage, histological type and the degree of optic nerve invasion.
  
  
  RESULTS
  The degree of RB optic nerve invasion was closely correlated to clinical stage and tumor differentiation.
  
  
  CONCLUSIONS
  Avoiding the risk factors of RB optic nerve invasion is very important for the prognosis of RB.
authors: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital University of Medical Sciences, Beijing 100730, China.
authors: Ruo-Jin
authors: RJ
authors: Ren
authors: Bin
authors: B
authors: Li
authors: Liao-Qing
authors: LQ
authors: Li
authors: Xian-Li
authors: XL
authors: Sun
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009367:Neoplasm Staging; D009900:Optic Nerve / Q000473:pathology*; D011379:Prognosis; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D012175:Retinoblastoma / Q000175:diagnosis / Q000473:pathology*; D012307:Risk Factors