[Intensity of lipid peroxydation and antioxidant enzyme activity in walls of the arteries and veins in monoiodacetate intoxication].
The intensity of the lipid peroxydation (LPO) and the antioxidant enzyme activity (gluthathione peroxydase, superoxide dismutase and catalase) after monoiodacetate injection (10 mg/ kg) within 3, 7 and 14 days was examined in the arterial and venous walls of rabbits. The increase in the amount of the intermediate and final LPO products, and also the reduction in the antioxidant enzymes activity has been found in the vessels of all types. The changes in the studied parameters were more expressed in the venous vessels, than in the arteries. It is supposed that the activation of LPO is caused by the primary depression of antioxidant systems which arises as the consequence of the disorders of energy exchange in the vascular wall under the influence of monoiodacetate.
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D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001158:Arteries / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D002374:Catalase / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000633:toxicity*; D005979:Glutathione Peroxidase / Q000037:antagonists & inhibitors; D019807:Iodoacetic Acid / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors; D014680:Veins / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*
D000975:Antioxidants; D004791:Enzyme Inhibitors; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D019807:Iodoacetic Acid