title: [Antiglucocorticoid, adrenonegative and antihypertensive effects of pyrogenal].
abstract: Intramuscular injection of pyrogenal (6.25 mcg/kg) to rats causes hypernitroxiduria, prevents a decrease of thymocytes count after subcutaneous injection of triamcinolone acetonide (2 mg/kg), leads to a moderate blood pressure decrease in hypertensive NISAG rats. Administration of equipotent dose of pyrogenal to mice (12.5 mcg/kg) reduces a mortality rate after subcutaneous injection of epinephrine (14 mg/kg). These results are discussed in the context of immunoprophylaxis of non-infectious pathology.
authors: I A
authors: IA
authors: Volchegorskiĭ
authors: V E
authors: VE
authors: Tseĭlikman
authors: L M
authors: LM
authors: Rassokhina
authors: Ia A
authors: IaA
authors: Vokhmintsev
authors: F B
authors: FB
authors: Kriukov
authors: A L
authors: AL
authors: Markel'
authors: D A
authors: DA
authors: Kozochkin
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002452:Cell Count; D004837:Epinephrine / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D005938:Glucocorticoids / Q000378:metabolism* / Q000494:pharmacology; D007273:Injections, Intramuscular; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D009566:Nitrates / Q000652:urine; D009569:Nitric Oxide / Q000096:biosynthesis; D009573:Nitrites / Q000652:urine; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects
chemical_list: D000276:Adjuvants, Immunologic; D000959:Antihypertensive Agents; D005938:Glucocorticoids; D008070:Lipopolysaccharides; D009566:Nitrates; D009573:Nitrites; C009136:pyrogenal; D009569:Nitric Oxide; D004837:Epinephrine