The total synthesis of neoamphimedine.
Neoamphimedine, a pyridoacridine alkaloid from Xestospongia sp., is a potent antitumor agent both in vitro and in vivo. Neoamphimedine can efficiently induce topoisomerase II mediated catenation of plasmid DNA in vitro and is the only member of more than one hundred pyridoacridines thus far to have this mechanism of action. Herein we report the first total synthesis of neoamphimedine.
LaBarbera
Daniel V
DV
Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Bugni
Tim S
TS
Ireland
Chris M
CM
D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000166:Acridines; C474173:neoamphimedine