Sixty-one patients with diabetic peripheral neuropathy treated by tongluo yangyin recipe.
OBJECTIVE
To observe the therapeutic effect of tongluo yangyin recipe (TLYYR) in patients with diabetic peripheral neuropathy (DPN).


METHODS
Ninety-nine patients with diabetes mellitus type 2 were assigned, according to the order of their visit, to two groups: 61 in the treated group and 38 in the control group. They were given the same information about diabetes mellitus and treated with the same therapy: strict diet control and Western drugs for hypoglycemia. In addition, the treated group received one dose (200 mL) of TLYYR in water decoction every day in two portions, while the control group had vitamin B1 100 mg and vitamin B12 250 microg administered daily via intramuscular injection. The course for all patients was 28 days.


RESULTS
The treated group experienced a therapeutic effect superior to that of the control group, with the difference between the total effective rates and the markedly effective rates (P<0.05, P<0.01). The blood levels of total cholesterol (TC) and triglyceride (TG) fell, the hemorrheological manner improved, the transmission velocity of the median nerve and common peroneal nerve significantly increased in the treated group after treatment (P<0.05), although the treatment showed no significant influence on blood glucose level (P>0.05).


CONCLUSIONS
TLYYR could promote blood microcirculation, improve nutritional metabolism of peripheral nerve, and thus accelerating DPN repair.
Xu
Wen-gang
WG
Hospital of Integrative Chinese and Western Medicine, Qingdao, Shandong, 266002, China. xuwengangxtc1999@163.com
D000368:Aged; D001786:Blood Glucose; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D018056:Hemorheology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009435:Synaptic Transmission / Q000187:drug effects; D016896:Treatment Outcome
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D008055:Lipids; C525737:tongluo yangyin