title: Meperidine prolongs lidocaine caudal epidural anaesthesia in the horse.
abstract: The aim of the study was to evaluate and compare the effects of caudal epidural administration of meperidine (MP), lidocaine (LD), and a combination of the two (MPLD) in six mature saddle horses. Horses were randomly assigned to receive three treatments (MP 0.3 mg/kg; LD 0.2 mg/kg; and MPLD: MP 0.3 mg/kg and LD 0.2 mg/kg), with at least 1 week between treatments. Drugs were injected into the epidural space between the first and second coccygeal areas in conscious standing horses. Analgesia, ataxia, sedation, cardiovascular and respiratory effects, and rectal temperature were recorded at different intervals before (baseline) and after administration. Epidural administration of MPLD resulted in a longer duration of analgesia of the tail, perineum, and upper hind limb regions than did administration of MP or LD alone.
authors: Department of Veterinary Medicine, Surgery and Anaesthesiology, Faculty of Veterinary Medicine, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil. derossi@nin.ufms.br
authors: Rafael
authors: R
authors: Derossi
authors: Ulisses
authors: U
authors: Medeiros
authors: Ricardo G
authors: RG
authors: de Almeida
authors: Fernando R
authors: FR
authors: Righetto
authors: Fabrício O
authors: FO
authors: Frazílio
mesh_terms: D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D000767:Anesthesia, Epidural / Q000379:methods / Q000662:veterinary*; D000818:Animals; D004357:Drug Synergism; D005260:Female; D006736:Horses / Q000378:metabolism*; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008614:Meperidine / Q000494:pharmacology*; D010146:Pain / Q000517:prevention & control; D011897:Random Allocation
chemical_list: D000759:Adjuvants, Anesthesia; D008012:Lidocaine; D008614:Meperidine