The ansacarbamitocins: polar ansamitocin derivatives.
The ansacarbamitocins are a new family of maytansinoids that are unusually substituted with a glucose subunit and two carbamate functional groups and exhibit modest activity against some agricultural fungal disease organisms. Ansacarbamitocins A-F ( 1- 6) all consist of the same macrocyclic core as the ansamitocins, with variation occurring on the glucose unit, while ansacarbamitocins A1 and B1 ( 7, 8) additionally lack the epoxide group on C-4 and C-5.
Snipes
Carl E
CE
Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA.
Duebelbeis
Dennis O
DO
Olson
Monica
M
Hahn
Donald R
DR
Dent
William H
WH
Gilbert
Jeffrey R
JR
Werk
Todd L
TL
Davis
George E
GE
Lee-Lu
Rebecca
R
Graupner
Paul R
PR
D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000187:drug effects; D008453:Maytansine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D008453:Maytansine; C015682:ansamitocins