Differential radiation effect in tumor and normal tissue after treatment with ramipril, an angiotensin-converting enzyme inhibitor.
The angiotensin-converting enzyme inhibitor, ramipril, has been shown to mitigate radiation injury in normal tissues. Using A549 cell xenografts grown in athymic mice, we measured the effect of ramipril on radiation damage to tumors. Ramipril did not alter tumor response to radiation despite different times of drug administration with respect to radiation delivery (drug started 2 weeks before or immediately after irradiation). In contrast, using the same dose, ramipril reduced normal tissue radiation injury (30 Gy x 2 or 6 Gy x 10) as assessed by a semi-quantitative scale of skin damage and relative leg contraction. The results indicate that ramipril could offer therapeutic gain due to its different effect on normal tissues and tumors.
Kohl
Robert R
RR
Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Kolozsvary
Andrew
A
Brown
Stephen L
SL
Zhu
Guopei
G
Kim
Jae Ho
JH
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009119:Muscle Contraction / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000532:radiotherapy*; D017257:Ramipril / Q000494:pharmacology*; D012867:Skin / Q000528:radiation effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D017257:Ramipril