title: Chronic infections and atherosclerosis.
abstract: Immunoinflammatory processes due to chronic infection are thought to be one of the definitive atherogenetic processes. Especially, anti-heat shock protein antibodies have been related to the prevalence of disease such as coronary artery disease or cerebral infarction, etc., resulted from atherosclerosis. Furthermore, the presence of HSP60-specific T lymphocytes in circulation may increase the risk of atherosclerosis. We have recently demonstrated the evidences that Helicobacter pylori infection induced atherosclerosis in apoe+/- ldlr+/- mice and that Hp-anti-heat-shock protein specific Th1-dominant immune responses had a major involvement in the progression of atherosclerosis. These cellular immune responses caused autoimmunity against endogenous HSP60 (expressed on the stressed cells of vascular endothelium), due to the molecular mimicry. Therefore, an appropriate treatment with antibiotics or with anti-HSP60 antibodies, which regulates the Th1 induction, could sufficiently reduce the progression of atherosclerosis.
authors: Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
authors: Kiyoshi
authors: K
authors: Ayada
authors: Kenji
authors: K
authors: Yokota
authors: Kazuko
authors: K
authors: Kobayashi
authors: Yehuda
authors: Y
authors: Shoenfeld
authors: Eiji
authors: E
authors: Matsuura
authors: Keiji
authors: K
authors: Oguma
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000150:complications* / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D018834:Chaperonin 60 / Q000276:immunology; D002908:Chronic Disease; D016481:Helicobacter Infections / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007239:Infections / Q000150:complications* / Q000276:immunology*; D051379:Mice; D018716:Molecular Mimicry; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001324:Autoantigens; D018834:Chaperonin 60