title: Complex multidrug therapy in a patient with pulmonary hypertension before and after orthotopic heart transplantation. A case report.
abstract: Pulmonary arterial hypertension represents an absolute contraindication for heart transplantation. We report the case of a 30-year-old man with end-stage heart failure due to restrictive cardiomyopathy and pulmonary arterial hypertension. A complex multidrug therapy improved pulmonary haemodynamics to the point that orthotopic heart transplantation could be carried out. At 18-month follow-up after heart transplantation, the patient's cardiac function made a full recovery. Larger prospective studies are warranted to support these results.
authors: Department of Cardiology, Second University of Naples, Monaldi Hospital, Via D. Fontana 81, Naples, Italy. mic.dalto@tin.it
authors: Michele
authors: M
authors: D'Alto
authors: Dionigia
authors: D
authors: Alfano
authors: Ciro
authors: C
authors: Maiello
authors: Berardo
authors: B
authors: Sarubbi
authors: Giuseppe
authors: G
authors: Santoro
authors: Paola
authors: P
authors: Argiento
authors: Nicola
authors: N
authors: Galdieri
authors: Maria G
authors: MG
authors: Russo
authors: Maurizio
authors: M
authors: Cotrufo
authors: Raffaele
authors: R
authors: Calabrò
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D000077300:Bosentan; D006328:Cardiac Catheterization; D002313:Cardiomyopathy, Restrictive / Q000150:complications / Q000503:physiopathology; D000075202:Contraindications; D004359:Drug Therapy, Combination; D011464:Epoprostenol / Q000008:administration & dosage*; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D016027:Heart Transplantation; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D013449:Sulfonamides / Q000008:administration & dosage*
chemical_list: D000959:Antihypertensive Agents; D013449:Sulfonamides; D011464:Epoprostenol; D000077300:Bosentan