title: Fast and controlled release of triamcinolone acetonide from extrusion-spheronization pellets based on mixtures of native starch with dextrin or waxy maize starch.
abstract: Pellets composed chiefly of inexpensive starches allow modulation of the rate of release of the poorly soluble drug triamcinolone acetonide in media of pH 1.2-6.8. Wheat- or maize-starch-based pellets with 20% of white dextrin release the drug in vitro almost completely within 20 min, while maize-starch-based pellets with 5-35% of waxy maize starch sustain gradual release over periods of 9-12 hr or longer when prepared using appropriate amounts of granulation fluid.
authors: Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
authors: Almeida-Prieto
authors: AP
authors: Sergio
authors: de Sá Ferreira da Rocha Cristiana
authors: de SF
authors: Isabel
authors: Blanco-Méndez
authors: BM
authors: José
authors: Francisco J
authors: FJ
authors: Otero-Espinar
mesh_terms: D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D003912:Dextrins / Q000737:chemistry*; D004304:Dosage Forms; D005079:Excipients / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D013213:Starch / Q000737:chemistry*; D014222:Triamcinolone Acetonide / Q000737:chemistry*; D014908:Triticum / Q000737:chemistry; D014885:Waxes / Q000737:chemistry; D003313:Zea mays / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D003912:Dextrins; D004304:Dosage Forms; D005079:Excipients; D014885:Waxes; D013213:Starch; D014222:Triamcinolone Acetonide