title: [Splenic T-cell and NK-cell lymphomas: a clinicopathologic and immunophenotypic analysis of 9 cases].
abstract: OBJECTIVE
  To explore the clinicopathologic features and diagnosis of splenic T-cell and NK-cell neoplasms.
  
  
  METHODS
  Nine cases of splenic T-cell and NK-cell neoplasms were collected and studied by morphology, immunophenotyping, EBER in situ hybridization and TCR-gamma gene rearrangement. Antibodies used were as follows: CD45RO, CD3epsilon, CD3, CD4, CD8, CD56, TIA-1, GranzymeB, CD30, Ki-67 and CD20.
  
  
  RESULTS
  Among the 9 cases, hepatosplenic T-cell lymphoma (HSTCL) and extranodal nasal type NK/T-cell lymphoma (NK/TCL) were both of 4 cases, and the remaining one was peripheral T-cell lymphoma, unspecified (PTL, unspecified). Follow up data were available for 7 cases. Five patients including 2 with HSTCL, 2 with extranodal nasal type NK/TCL and one with PTL, unspecified died, with survival times ranged from 1 to 10 months. The other two patients are still alive, one with NK/TCL (two months+) and one with HSTCL (14+ months).
  
  
  CONCLUSIONS
  Splenic T-cell and NK-cell neoplasms are a group of uncommon lymphomas with heterogeneous clinicopathologic features and poor prognosis. A definite diagnosis must depend on clinical manifestations, histopathology, immunophenotype and TCR gene rearrangement analysis.
authors: Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, China.
authors: Zheng
authors: Z
authors: Li
authors: Wei-Ping
authors: WP
authors: Liu
authors: Yuan
authors: Y
authors: Tang
authors: Li-Li
authors: LL
authors: Jiang
authors: Wen-Yan
authors: WY
authors: Zhang
authors: Cheng-Feng
authors: CF
authors: Bi
authors: Gan-Di
authors: GD
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D015321:Gene Rearrangement; D006801:Humans; D016130:Immunophenotyping; D054391:Lymphoma, Extranodal NK-T-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*