Management of ocular surface inflammation in Sjögren syndrome.
OBJECTIVE
To evaluate the clinical efficacy of anti-inflammatory therapy in the management of primary Sjögren syndrome.


METHODS
Thirty-eight patients with primary Sjögren syndrome were included in this study. The diagnosis of Sjögren syndrome was made on the basis of the classification criteria of the American-European Consensus Group. Fluorescein staining score, rose-bengal staining score, Schirmer test score, tear film breakup time, and functional parameters including ocular surface disease index (OSDI) and visual analog scale (VAS) score were measured at the first visit. Anti-inflammatory therapy included topical corticosteroids, topical autologous serum, and topical cyclosporin A. The clinical efficacy of anti-inflammatory treatment was evaluated in terms of subjective symptoms and objective signs (including Schirmer-1 test, breakup time, rose-bengal score, and fluorescein score).


RESULTS
Patients with Sjögren syndrome had higher rose-bengal scores than patients with non-Sjögren dry eye (P < 0.05). The OSDI score showed better correlation with fluorescein score than with VAS score. Subjective symptoms improved with anti-inflammatory treatment in 70% of patients with primary Sjögren syndrome. Anti-inflammatory treatment provided significant improvement in visual acuity and fluorescein score but did not affect Schirmer score, tear breakup time, or rose-bengal score.


CONCLUSIONS
Anti-inflammatory therapy in primary Sjögren syndrome significantly improved subjective symptoms and objective ocular signs; however, we did not find evidence that anti-inflammatory treatment increases tear production in patients with Sjögren syndrome.
Hyon
Joon Young
JY
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Goomi-dong, Bundang-gu, Seongnam, Gyeonggi 463-707, Korea. jyhyon@snu.ac.kr
Lee
Yun Jong
YJ
Yun
Pil-Young
PY
D016572:Cyclosporine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008875:Middle Aged; D009883:Ophthalmic Solutions; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D009883:Ophthalmic Solutions; D016572:Cyclosporine