title: Temozolomide treatment of an adult with a relapsing medulloblastoma.
abstract: Temozolomide is an oral cytotoxic agent that has demonstrated its interest in high grade glioma tumors. This drug can be used either concomitantly with radiotherapy or as chemotherapy. The prognosis of relapsing medulloblastoma is poor and treatment is often difficult, especially after radiotherapy. Here, we report the use of temozolomide in an adult presenting relapsing medulloblastoma. An initial partial response was observed for this previously heavily treated patient. This observation suggests this drug may be useful in medulloblastoma, either as conventional chemotherapy or for use together with radiotherapy.
authors: Département D'Oncologie Médicale, Centre Jean Perrin, Clermont-Ferrand, France. Xavier.DURANDO@cjp.fr
authors: X
authors: X
authors: Durando
authors: Emilie
authors: E
authors: Thivat
authors: Olivier
authors: O
authors: Gilliot
authors: Bernard
authors: B
authors: Irthum
authors: Pierre
authors: P
authors: Verrelle
authors: Catherine
authors: C
authors: Vincent
authors: Jacques-Olivier
authors: JO
authors: Bay
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D011877:Radionuclide Imaging; D000077204:Temozolomide; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide