title: Sequential clot strength analyses following diclofenac in pediatric adenotonsillectomy.
abstract: BACKGROUND
  Tonsillectomy is a common pediatric surgical procedure resulting in significant postoperative pain. There is ongoing controversy as to the most satisfactory analgesic regimen. Nonsteroidal antiinflammatory drugs (NSAIDs) are an alternative to opioids in this setting. NSAID use in tonsillectomy has been shown to be opioid sparing in the recovery period and to have similar analgesic effects to opioids in pediatric patients. Because of their nonspecific action on the enzyme cyclo-oxygenase there is potential for increased bleeding which has led many practitioners to avoid NSAIDs completely in this patient population potentially resulting in suboptimal pain control. Our aim in this study was to assess the effect of preoperatively administered diclofenac on the blood clot strength in children undergoing (adeno-) tonsillectomy.
  
  
  METHODS
  Twenty patients undergoing (adeno-) tonsillectomy were recruited into this prospective observational study. All patients received 2 mg.kg(-1) of diclofenac rectally immediately preoperatively. Blood was taken for thromboelastograph analysis pre-diclofenac and 1 and 4 h post-diclofenac administration.
  
  
  RESULTS
  There was a statistically significant increase in maximal clot strength (MA) at 1 and 4 h after diclofenac. Similarly there was a statistically significant reduction in time to initial fibrin formation (R time) post-diclofenac. There was no primary or secondary hemorrhage.
  
  
  CONCLUSIONS
  Diclofenac when given preoperatively does not adversely affect clot strength in the immediate postoperative period when the risk of primary hemorrhage is greatest.
authors: Department of Anaesthesia and Critical Care Medicine, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland.
authors: Mairead
authors: M
authors: Heaney
authors: Yvonne
authors: Y
authors: Looney
authors: Caleb
authors: C
authors: McKinstry
authors: Brendan
authors: B
authors: O'Hare
mesh_terms: D000233:Adenoidectomy; D000234:Adenoids / Q000601:surgery*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D002675:Child, Preschool; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D011300:Preoperative Care / Q000379:methods; D011446:Prospective Studies; D013916:Thrombelastography / Q000187:drug effects*; D013997:Time Factors; D014068:Tonsillectomy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac