title: Foxp3+ regulatory T cells: selfishness under scrutiny.
abstract: The Foxp3+ T cell lineage is thought to arise from self-specific precursors during development. By using a unique mouse model, Pacholczyk et al. (2007) present compelling evidence that self-specific cells are exceedingly rare among Foxp3(-) and, surprisingly, Foxp3+ subsets.
authors: Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors: Geoffrey L
authors: GL
authors: Stephens
authors: Ethan M
authors: EM
authors: Shevach
mesh_terms: D000818:Animals; D051858:Forkhead Transcription Factors / Q000276:immunology*; D006801:Humans; D051379:Mice; D017634:Self Tolerance / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors