Antimalarial benzoquinones from an endophytic fungus, Xylaria sp.
Two novel benzoquinone metabolites, 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione ( 1) and xylariaquinone A ( 2) together with two known compounds were isolated from an endophytic fungus, Xylaria sp. Their structures were assigned by analysis of spectroscopic data, and the structures of 1 and 3 were also confirmed by single-crystal X-ray data. Compounds 1 and 2 showed in vitro activity against Plasmodium falciparum, K1 strain, with IC 50 values of 1.84 and 6.68 microM and cytotoxicity against African green monkey kidney fibroblasts (Vero cells) with IC 50 values of 1.35 and >184 microM, respectively.
Tansuwan
Srinuan
S
Program of Biotechnology, Faculty of Science, Chulalongkorn University, Phyathai Road, Bangkok 10330, Thailand.
Pornpakakul
Surachai
S
Roengsumran
Sophon
S
Petsom
Amorn
A
Muangsin
Nongnuj
N
Sihanonta
Prakitsin
P
Chaichit
Narongsak
N
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D018360:Crystallography, X-Ray; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*; D013785:Thailand; D014709:Vero Cells; D013098:Xylariales / Q000737:chemistry*
D000962:Antimalarials; D016227:Benzoquinones