title: Heat-shock protein 65 autoantibodies are differently associated with early atherosclerosis in rheumatoid arthritis and in healthy subjects.
abstract: The aim of this study was to examine whether heat-shock protein (HSP)-65 autoantibodies are associated with early atherosclerosis in rheumatoid arthritis (RA). Intima-media thickness (IMT) was measured in the carotid arteries of 100 RA patients and 69 control subjects. The IMT was evaluated on both carotid arteries in the common carotid, bifurcation, and internal arteries. Every patient underwent anti-HSP-65 antibody evaluation. Anti-HSP-65 antibodies were not more prevalent among patients compared with controls. Among controls, patients having "positive" anti-HSP-65 tended to have increased carotid artery IMT compared with "negative" patients, whereas among RA patients the opposite association was noted, and positive patients had significantly decreased carotid bifurcation IMT than negative patients without elevated levels of anti-HSP-65. As opposed to the association with cardiovascular diseases and atherosclerosis of anti-HSPs in the general population, among RA patients anti-HSP-65 cannot be regarded as associated with early atherosclerosis.
authors: Department of Medicine 'B' and Center of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
authors: Yaniv
authors: Y
authors: Sherer
authors: Roberto
authors: R
authors: Gerli
authors: Elena Bartoloni
authors: EB
authors: Bocci
authors: Boris
authors: B
authors: Gilburd
authors: Gaetano
authors: G
authors: Vaudo
authors: Onelia
authors: O
authors: Bistoni
authors: Yehuda
authors: Y
authors: Shoenfeld
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications / Q000276:immunology; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014463:Ultrasonography; D018834:Chaperonin 60; D024101:Mitochondrial Proteins
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; D006360:Heat-Shock Proteins; C060293:HSPD1 protein, human; D018834:Chaperonin 60; D024101:Mitochondrial Proteins