In vitro characterization of the Gd complex of [2,6-pyridinediylbis(methylene nitrilo)] tetraacetic acid (PMN-tetraacetic acid) and of its Eu analogue, suitable bimodal contrast agents for MRI and optical imaging.
Gd and Eu complexes of PMN-tetraacetic acid show interesting properties either for MRI or for optical imaging; that is, for the Gd-complex, a high proton relaxivity with favorable water residence time; for the Eu-complex, a luminescence lifetime of 400 micros at room temperature compatible with the use of time-resolved luminescence technique. Both complexes have a good stability in physiological medium.
Laurent
S
S
NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, University of Mons-Hainaut, B-7000 Mons, Belgium. sophie.laurent@umh.ac.be
Vander Elst
L
L
Wautier
M
M
Galaup
C
C
Muller
R N
RN
Picard
C
C
D000085:Acetates / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D049408:Luminescent Agents / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
C527753:(2,6-pyridinediylbis(methylene nitrilo)) tetraacetic acid; D000085:Acetates; D003287:Contrast Media; D049408:Luminescent Agents; D009570:Nitriles; D009942:Organometallic Compounds; D011725:Pyridines; D005063:Europium; D005682:Gadolinium