Functional membrane diffusion of G-protein coupled receptors.
G-protein-coupled receptor function involves interactions between the receptor, G-proteins and effectors in the cell plasma membrane. The main biochemical processes have been individually identified but the mechanisms governing the successive protein-protein interactions of this complex multi-molecular machinery have yet to be established. We discuss advances in understanding the functional dynamics of the receptor resulting from diffusion measurements, and in the context of the plasma membrane organization.
Baker
Aurélie
A
Institut de Pharmacologie et Biologie Structurale, UMR CNRS-Université Paul Sabatier 5089, 205, route de Narbonne, 31077, Toulouse cedex 09, France.
Saulière
Aude
A
Dumas
Fabrice
F
Millot
Claire
C
Mazères
Serge
S
Lopez
André
A
Salomé
Laurence
L
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D004058:Diffusion; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D038761:Photobleaching; D043562:Receptors, G-Protein-Coupled / Q000502:physiology*; D013050:Spectrometry, Fluorescence; D013696:Temperature
D008024:Ligands; D043562:Receptors, G-Protein-Coupled