title: Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells.
abstract: BACKGROUND
  Although a huge amount of mammalian genomic data does become publicly available, there are still hurdles for biologists to overcome before such data can be fully exploited. One of the challenges for gaining biological insight from genomic data has been the inability to cross-reference transcriptomic and proteomic data using a single informational platform. To address this, we constructed an open-access database that enabled us to cross-reference transcriptomic and proteomic data obtained from immune cells.
  
  
  RESULTS
  The database, named RefDIC (Reference genomics Database of Immune Cells), currently contains: (i) quantitative mRNA profiles for human and mouse immune cells/tissues obtained using Affymetrix GeneChip technology; (ii) quantitative protein profiles for mouse immune cells obtained using two-dimensional gel electrophoresis (2-DE) followed by image analysis and mass spectrometry and (iii) various visualization tools to cross-reference the mRNA and protein profiles of immune cells. RefDIC is the first open-access database for immunogenomics and serves as an important information-sharing platform, enabling a focused genomic approach in immunology.
  
  
  BACKGROUND
  All raw data and information can be accessed from http://refdic.rcai.riken.jp/. The microarray data is also available at http://cibex.nig.ac.jp/ under CIBEX accession no. CBX19, and http://www.ebi.ac.uk/pride/ under PRIDE accession numbers 2354-2378 and 2414.
authors: RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan.
authors: Atsushi
authors: A
authors: Hijikata
authors: Hiroshi
authors: H
authors: Kitamura
authors: Yayoi
authors: Y
authors: Kimura
authors: Ryo
authors: R
authors: Yokoyama
authors: Yuichi
authors: Y
authors: Aiba
authors: Yanyuan
authors: Y
authors: Bao
authors: Shigeharu
authors: S
authors: Fujita
authors: Koji
authors: K
authors: Hase
authors: Shohei
authors: S
authors: Hori
authors: Yasuyuki
authors: Y
authors: Ishii
authors: Osami
authors: O
authors: Kanagawa
authors: Hiroshi
authors: H
authors: Kawamoto
authors: Kazuya
authors: K
authors: Kawano
authors: Haruhiko
authors: H
authors: Koseki
authors: Masato
authors: M
authors: Kubo
authors: Ai
authors: A
authors: Kurita-Miki
authors: Tomohiro
authors: T
authors: Kurosaki
authors: Kyoko
authors: K
authors: Masuda
authors: Mitsumasa
authors: M
authors: Nakata
authors: Keisuke
authors: K
authors: Oboki
authors: Hiroshi
authors: H
authors: Ohno
authors: Mariko
authors: M
authors: Okamoto
authors: Yoshimichi
authors: Y
authors: Okayama
authors: Jiyang
authors: J
authors: O-Wang
authors: Hirohisa
authors: H
authors: Saito
authors: Takashi
authors: T
authors: Saito
authors: Machie
authors: M
authors: Sakuma
authors: Katsuaki
authors: K
authors: Sato
authors: Kaori
authors: K
authors: Sato
authors: Ken-ichiro
authors: K
authors: Seino
authors: Ruka
authors: R
authors: Setoguchi
authors: Yuki
authors: Y
authors: Tamura
authors: Masato
authors: M
authors: Tanaka
authors: Masaru
authors: M
authors: Taniguchi
authors: Ichiro
authors: I
authors: Taniuchi
authors: Annabelle
authors: A
authors: Teng
authors: Takeshi
authors: T
authors: Watanabe
authors: Hiroshi
authors: H
authors: Watarai
authors: Sho
authors: S
authors: Yamasaki
authors: Osamu
authors: O
authors: Ohara
mesh_terms: D000818:Animals; D003628:Database Management Systems; D016208:Databases, Factual; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods*; D020407:Internet; D008214:Lymphocytes / Q000276:immunology*; D020543:Proteome / Q000276:immunology*; D018511:Systems Integration; D014157:Transcription Factors / Q000276:immunology*
chemical_list: D020543:Proteome; D014157:Transcription Factors