title: Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors.
abstract: Development of cis-2,4,6-trisubstituted piperidine N-arylsulfonamides as gamma-secretase inhibitors for the potential treatment of Alzheimer's disease (AD) is reported.
authors: Department of Chemical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. hongmei.li@spcorp.cpm
authors: Hongmei
authors: H
authors: Li
authors: Theodros
authors: T
authors: Asberom
authors: Thomas A
authors: TA
authors: Bara
authors: John W
authors: JW
authors: Clader
authors: William J
authors: WJ
authors: Greenlee
authors: Hubert B
authors: HB
authors: Josien
authors: Mark D
authors: MD
authors: McBriar
authors: Amin
authors: A
authors: Nomeir
authors: Dmitri A
authors: DA
authors: Pissarnitski
authors: Murali
authors: M
authors: Rajagopalan
authors: Ruo
authors: R
authors: Xu
authors: Zhiqiang
authors: Z
authors: Zhao
authors: Lixin
authors: L
authors: Song
authors: Lili
authors: L
authors: Zhang
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D051544:Cytochrome P-450 CYP3A / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D010880:Piperidines; D013449:Sulfonamides; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D053829:Amyloid Precursor Protein Secretases