title: Role of Moringa oleifera on enterochromaffin cell count and serotonin content of experimental ulcer model.
abstract: The present study has been undertaken to observe the effect of aqueous extract of M. oleifera (MO) leaf (300mg/kg body weight) on mean ulcer index, enterochromaffin (EC) cells and serotonin (5-hydroxytryptamine; 5-HT) content of ulcerated gastric tissue. Ulceration was induced by using aspirin (500 mg/kg, po), cerebellar nodular lesion and applying cold stress. In all cases increased mean ulcer index in gastric tissue along with decreased EC cell count was observed with concomitant decrease of 5-HT content. Pretreatment with MO for 14 days decreased mean ulcer index, increased both EC cell count and 5-HT content in all ulcerated group, but treatment with ondansetron, a 5-HT3 receptor antagonist, along with MO pretreatment increased mean ulcer index, decreased 5-HT content without any alteration in EC cell count. The results suggest that the protective effect of MO on ulceration is mediated by increased EC cell count and 5-HT levels which may act via 5-HT3 receptors on gastric tissue.
authors: S N Pradhan Centre for Neurosciences, University of Calcutta, 244 B A.J.C. Bose Road, Kolkata 700 020.
authors: Siddhartha
authors: S
authors: Debnath
authors: Debjani
authors: D
authors: Guha
mesh_terms: D000818:Animals; D002452:Cell Count; D004195:Disease Models, Animal; D004759:Enterochromaffin Cells / Q000737:chemistry* / Q000166:cytology / Q000187:drug effects*; D029588:Moringa oleifera / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D014867:Water / Q000737:chemistry
chemical_list: D010936:Plant Extracts; D014867:Water; D012701:Serotonin