BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport.
BK virus is an important pathogen in kidney transplant recipients. In vitro studies demonstrated slight antiviral activity for chloroquine and nystatin. A sialic acid derivative, BTB11968, was identified as a lead compound for further development.
Randhawa
Parmjeet
P
Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, UPMC-Montefiore Hospital, Pittsburgh, PA 15213, USA. randhawapa@upmc.edu
Farasati
Noush Afarin
NA
Huang
Yuchen
Y
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001739:BK Virus / Q000187:drug effects* / Q000502:physiology; D002460:Cell Line; D002738:Chloroquine / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009761:Nystatin / Q000737:chemistry / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D009761:Nystatin; D002738:Chloroquine