Significance of bone marrow fibrosis in multiple myeloma.
OBJECTIVE
The aim of the current study was to asses the frequency of increased fibrosis in myeloma and to find its correlation with other bone marrow parameters and survival.


METHODS
Forty-four multiple myeloma patients diagnosed between 2001 and 2005 were included in the present study. A detailed study of the bone marrow aspiration smears and trephine biopsy was done. Bone marrow fibrosis was graded and correlated with other parameters like plasma cell morphology, pattern of infiltration, mitotic activity and also with the survival of the patients.


RESULTS
Increased fibrosis was seen in nine cases (20.5%). It was observed that plasma cell burden in the marrow was under-estimated in the aspirate smears compared with the trephine biopsy in patients with increased fibrosis. Increased marrow fibrosis correlated significantly with poorly differentiated plasma cell morphology (p = 0.020) and mitotic activity (p = 0.003), which by themselves are established prognostic markers for survival in multiple myeloma. Patients with increased fibrosis of the marrow also had a median survival time of just 11 months.


CONCLUSIONS
A bone marrow trephine biopsy is essential in all cases of myeloma at diagnosis, as it helps identify a subset of myeloma patients with increased marrow fibrosis and poorer prognosis.
Subramanian
Rajiv
R
Department of Pathology, JIPMER, Dhanvantari Nagar, Pondicherry 605006, India.
Basu
Debdatta
D
Dutta
Tarun K
TK
D000328:Adult; D000368:Aged; D001706:Biopsy; D001856:Bone Marrow Examination; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000401:mortality / Q000473:pathology*; D055728:Primary Myelofibrosis / Q000150:complications* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis