title: Biological activities of extracts from endophytic fungi isolated from Garcinia plants.
abstract: Sixty-five crude extracts from 51 selected endophytic fungi isolated from Garcinia species were tested for various bioactivities. Eighty per cent of the fungal extracts from fermentation broths and mycelia displayed bioactivities: antimycobacterial (76.9%), antimalarial (14.1%), antiviral (16.7%), antioxidant (22.2%), antiproliferation (11.1% against NCI-H187 and 12.7% against KB cells), and cytotoxicity to Vero cells (40.0%). Based on internal transcribed spacer rRNA sequence analysis, 15 bioactive isolates were identified as Aspergillus, Botryosphaeria, Curvularia, Fusicoccum, Guignardia, Muscodor, Penicillium, Pestalotiopsis, and Phomopsis spp. One isolate (N24) was matched with an unidentified fungal endophyte. These results indicate that endophytic fungi isolated from Garcinia plants in Thailand are potential sources of various bioactive natural products.
authors: Natural Products Research Unit, Department of Microbiology, Faculty of Science, Prince of Songkla University, Songkhla, Thailand. souwalak.p@psu.ac.th
authors: Souwalak
authors: S
authors: Phongpaichit
authors: Jaru
authors: J
authors: Nikom
authors: Nattawut
authors: N
authors: Rungjindamai
authors: Jariya
authors: J
authors: Sakayaroj
authors: Nongporn
authors: N
authors: Hutadilok-Towatana
authors: Vatcharin
authors: V
authors: Rukachaisirikul
authors: Kanyawim
authors: K
authors: Kirtikara
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D002460:Cell Line / Q000187:drug effects; D002522:Chlorocebus aethiops; D045424:Complex Mixtures / Q000494:pharmacology / Q000633:toxicity; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021901:DNA, Intergenic / Q000737:chemistry / Q000235:genetics; D005658:Fungi / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D029760:Garcinia / Q000382:microbiology*; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D000975:Antioxidants; D000995:Antitubercular Agents; D000998:Antiviral Agents; D045424:Complex Mixtures; D004271:DNA, Fungal; D021901:DNA, Intergenic