title: First phase release coefficient of insulin in subjects with normal glucose tolerance on glucose infusion analyzed by computer simulation.
abstract: We report here a mathematical model using computer simulation to solve the phase fractionation coefficient (f) of instantaneous insulin release on glucose infusion. By extensive model testing with the cited parameters obtained from the literature, the values of the factor f were shown to lie in range of 0.93+/-0.02 (mean+/-2S.D., n=15), indicating that the high pulsatile bolus of glucose by i.v. infusion may trigger acute insulin release (AIR) corresponding to a fraction of more than 90% of the stored insulin release in the first phase from the secretory granules of pancreatic beta cells. In addition, the value of the factor f was shown to be independent of both the glucose infusion method and the non-insulin-dependent uptake of glucose.
authors: School of Medicines, Chung-Shan Medical University, 110 Section 1, Chien-Kuo North Road, Taichung, Taiwan.
authors: Chien-Ning
authors: CN
authors: Huang
authors: Wen-Chih
authors: WC
authors: Chou
authors: Li-Yun
authors: LY
authors: Lin
authors: Chiung-Chi
authors: CC
authors: Peng
authors: Charng-Cherng
authors: CC
authors: Chyau
authors: Kuan-Chou
authors: KC
authors: Chen
authors: Robert Y
authors: RY
authors: Peng
mesh_terms: D003198:Computer Simulation; D005947:Glucose / Q000008:administration & dosage* / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D007328:Insulin; D005947:Glucose