Chemotherapeutic implants via subcritical CO2 modification.
Polymer-based biomaterials have a broad range of current applications in medicine. Many implants generate a favorable biomedical outcome solely by providing short-term mechanical stability that allows healing of the surrounding tissues. An example is polymeric reconstructive resorbable plates having initial strengths sufficient to stabilize bone segments while allowing the osteosynthesis needed to restore original function following tumor resection. Simultaneous, localized delivery of the widely employed chemotherapeutic paclitaxel following tumor removal presents a particularly desirable goal in this context. By using compressed/subcritical CO(2) at moderate pressures (as opposed to the more familiar supercritical pressures) to embed paclitaxel in clinically utilized reconstructive plating, the form of the implant can be preserved while adding an inherently localized chemotherapeutic function. In vitro tests demonstrate the efficacy of the embedded paclitaxel against adherent MCF-7 breast cancer cells within the immediate area of the polylactic acid (PLA). CO(2) can be utilized to add dual structural-chemotherapeutic function to polymeric surfaces without a change in form. The ability to 'piggyback' chemotherapeutic function into nearly any polymeric surface should find widespread utility.
Powell
Heather M
HM
Department of Materials Science and Engineering, Ohio State University, Columbus, OH 43210, USA.
Ayodeji
Olukemi
O
Summerfield
Taryn L
TL
Powell
David M
DM
Kniss
Douglas A
DA
Tomasko
David L
DL
Lannutti
John J
JJ
D017209:Apoptosis; D002245:Carbon Dioxide / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants
D002245:Carbon Dioxide