title: Effect of exocrine pancreatic function on resting energy expenditure in cystic fibrosis.
abstract: OBJECTIVE
  To prove the hypothesis that exocrine pancreatic function determines resting energy expenditure (REE) in cystic fibrosis (CF).
  
  
  METHODS
  Thirty-eight CF individuals, 9-34 (19.98 +/- 1.0) years, were divided into three groups: Six pancreatic sufficient patients (PS; group A), 21 pancreatic insufficient patients (PI), whose pulmonary function was comparable to that of group A (group B1) and 11 PI patients, whose pulmonary function was significantly worse than that of group A (group B2). REE was estimated by indirect calorimetry. Predicted REE was based on Schofield equations. Measured REE was expressed as % of the predicted. BMI, BMI z-scores, serum albumin, cholesterol and triglycerides levels were related to REE. Results were expressed as mean +/- standard error.
  
  
  RESULTS
  Groups B1 and B2 had significantly higher REE% (111.7 +/- 2.75% and 119.94 +/- 3.8, respectively) as opposed to group A (98.9 +/- 3.81%; p = 0.022 and 0.035, respectively) whose REE% was similar to that predicted. REE% between group B1 and B2 was not statistically significant. In groups A, B1 and B, mean FEV1% was 86.33 +/- 10.1%, 90.24 +/- 4.39%, 44.54 +/- 3.47%, respectively, mean BMI was 25.6 +/- 2.06, 19.48 +/- 0.64 and 20.09 +/- 8.8, respectively, BMI z-scores were 0.75 +/- 0.51, -0.52 +/- 0.24 and -1.07 +/- 0.37, respectively. Significant correlation was demonstrated between REE%, BMI z-scores and cholesterol levels in group A.
  
  
  CONCLUSIONS
  Clinically stable CF patients, who had comparable pulmonary function, exhibited increased REE% only in the presence of exocrine pancreatic insufficiency. REE% strongly correlated with BMI z-scores in pancreatic sufficiency. These findings support the hypothesis that pancreatic rather than pulmonary function may determine nutritional status as well as REE in CF.
authors: Second Department of Pediatrics, Aristotle University of Thessaloniki, Greece. tmod@med.auth.gr
authors: T
authors: T
authors: Moudiou
authors: A
authors: A
authors: Galli-Tsinopoulou
authors: S
authors: S
authors: Nousia-Arvanitakis
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002151:Calorimetry; D015897:Comorbidity; D003550:Cystic Fibrosis / Q000503:physiopathology*; D004734:Energy Metabolism / Q000502:physiology*; D010188:Exocrine Pancreatic Insufficiency / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D009752:Nutritional Status; D046790:Pancreas, Exocrine / Q000502:physiology / Q000503:physiopathology*; D010182:Pancreatic Diseases / Q000175:diagnosis / Q000503:physiopathology; D012129:Respiratory Function Tests; D012146:Rest / Q000502:physiology*