Bioimaging in the mid-infrared using an organometallic carbonyl tag.
Two stable and water-soluble organometallic carbonyl cluster derivatives have been prepared and shown to enter the cell with ease. The CO stretching vibrations afford strong mid-infrared signals which have been demonstrated, for the first time, to be of utility in cell imaging via an IR microscope.
Kong
Kien Voon
KV
Department of Chemistry, National University of Singapore, Kent Ridge, Singapore 119260.
Chew
Wee
W
Lim
Lina Hsiu Kim
LH
Fan
Wai Yip
WY
Leong
Weng Kee
WK
D000447:Aldehydes / Q000737:chemistry*; D000818:Animals; D002477:Cells / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D012995:Solubility; D013055:Spectrophotometry, Infrared / Q000379:methods*; D014867:Water / Q000737:chemistry
D000447:Aldehydes; D009942:Organometallic Compounds; D014867:Water