title: Infertility associated with sub clinical salmonellosis.
abstract: Subclinical infection of guinea pigs with isogenic wild type and aroA, htrA and aroA-htrA mutants of Salmonella enterica subspecies enterica serovar Abortusequi (S. Abortusequi) induced infertility, while mutants had little or no effect on conception rate in guinea pigs. Conception rate was significantly lower in guinea pigs inoculated with wild type (S-787) and aroA mutant of S. Abortusequi than those inoculated with intracellular survival deficient htrA or aroA-htrA mutants of S. Abortusequi. Chi-test analysis revealed that none of the three mutants could be attributed to low conception rate, but wild type Salmonella inoculation and chronic carriage of the pathogen were significant cause of low conception rate in guinea pigs. Role of S. Abortusequi in causation of infertility was proven from the experiment for the first time.
authors: National Salmonella Centre (Vet.), Division of Bacteriology and Mycology, Indian Veterinary Research Institute, Izatnagar 243 122, India. brs1762@yahoo.co.in
authors: Bhoj Raj
authors: BR
authors: Singh
authors: Mudit
authors: M
authors: Chandra
authors: Ravikant
authors: R
authors: Agarwal
authors: N
authors: N
authors: Babu
mesh_terms: D000818:Animals; D005260:Female; D005798:Genes, Bacterial; D006168:Guinea Pigs; D007247:Infertility, Female / Q000209:etiology* / Q000382:microbiology; D008297:Male; D009154:Mutation; D012481:Salmonella Infections, Animal / Q000150:complications* / Q000382:microbiology; D019779:Salmonella enterica / Q000235:genetics / Q000472:pathogenicity