title: High-field, high-resolution, susceptibility-weighted magnetic resonance imaging: improved image quality by addition of contrast agent and higher field strength in patients with brain tumors.
abstract: BACKGROUND
  To demonstrate intratumoral susceptibility effects in malignant brain tumors and to assess visualization of susceptibility effects before and after administration of the paramagnetic contrast agent MultiHance (gadobenate dimeglumine; Bracco Imaging), an agent known to have high relaxivity, with respect to susceptibility effects, image quality, and reduction of scan time.
  
  
  METHODS
  Included in the study were 19 patients with malignant brain tumors who underwent high-resolution, susceptibility-weighted (SW) MR imaging at 3 T before and after administration of contrast agent. In all patients, Multihance was administered intravenously as a bolus (0.1 mmol/kg body weight). MR images were individually evaluated by two radiologists with previous experience in the evaluation of pre- and postcontrast 3-T SW MR images with respect to susceptibility effects, image quality, and reduction of scan time.
  
  
  RESULTS
  In the 19 patients 21 tumors were diagnosed, of which 18 demonstrated intralesional susceptibility effects both in pre- and postcontrast SW images, and 19 demonstrated contrast enhancement in both SW images and T1-weighted spin-echo MR images. Conspicuity of susceptibility effects and image quality were improved in postcontrast images compared with precontrast images and the scan time was also reduced due to decreased TE values from 9 min (precontrast) to 7 min (postcontrast).
  
  
  CONCLUSIONS
  The intravenous administration of MultiHance, an agent with high relaxivity, allowed a reduction of scan time from 9 min to 7 min while preserving excellent susceptibility effects and image quality in SW images obtained at 3 T. Contrast enhancement and intralesional susceptibility effects can be assessed in one sequence.
authors: MR Centre of Excellence, Department of Radiology, Medical University Vienna, Lazarettg. 14, 1090, Vienna, Austria.
authors: K
authors: K
authors: Pinker
authors: I M
authors: IM
authors: Noebauer-Huhmann
authors: I
authors: I
authors: Stavrou
authors: R
authors: R
authors: Hoeftberger
authors: P
authors: P
authors: Szomolanyi
authors: M
authors: M
authors: Weber
authors: A
authors: A
authors: Stadlbauer
authors: G
authors: G
authors: Grabner
authors: E
authors: E
authors: Knosp
authors: S
authors: S
authors: Trattnig
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000175:diagnosis; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage*; D004526:Efficiency; D004806:Ependymoma / Q000175:diagnosis; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives*; D008875:Middle Aged; D009837:Oligodendroglioma / Q000175:diagnosis; D009942:Organometallic Compounds; D010954:Plasmacytoma / Q000175:diagnosis; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine