Pharmacologic modulation of clodronate in local therapy of periodontal and implant inflammation.
Bisphosphonates are drugs used in the treatment of a variety of osteometabolic diseases. Recently they have been the object of research and studies on their potential application in dentistry and orthopedics. In particular, clodronate (non-aminobisphosphonates) has been studied, due to its reversible activity in comparison to apoptotic osteoclasts, the intrinsic action which stimulates the differentiation and activity of the osteoblasts, their antinflammatory activity, antipain and antioxidant action, represent the rational to estimate their clinical efficacy, for local use in dentistry, implatology, orthopaedic, rheumatology, oncology and dermatology.
Volpi
R
R
Italian Association for the Study of Bisphosphonates in Odontostomatology, Italy.
Rossi
F
F
Trisi
P
P
Testori
T
T
Berardi
D
D
Perfetti
G
G
D000818:Animals; D004002:Clodronic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D016207:Cytokines / Q000502:physiology; D003757:Dental Implantation / Q000009:adverse effects*; D006801:Humans; D007107:Immune System / Q000502:physiology; D009504:Neutrophils / Q000276:immunology; D010518:Periodontitis / Q000188:drug therapy* / Q000276:immunology; D053245:RANK Ligand / Q000502:physiology
D016207:Cytokines; D053245:RANK Ligand; C505688:TNFSF11 protein, human; D004002:Clodronic Acid