title: Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
abstract: Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented.
authors: DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA. george.p.lahm@usa.dupont.com
authors: George P
authors: GP
authors: Lahm
authors: Thomas M
authors: TM
authors: Stevenson
authors: Thomas P
authors: TP
authors: Selby
authors: John H
authors: JH
authors: Freudenberger
authors: Daniel
authors: D
authors: Cordova
authors: Lindsey
authors: L
authors: Flexner
authors: Cheryl A
authors: CA
authors: Bellin
authors: Christine M
authors: CM
authors: Dubas
authors: Ben K
authors: BK
authors: Smith
authors: Kenneth A
authors: KA
authors: Hughes
authors: J Gary
authors: JG
authors: Hollingshaus
authors: Christopher E
authors: CE
authors: Clark
authors: Eric A
authors: EA
authors: Benner
mesh_terms: D000818:Animals; D002460:Cell Line; D006801:Humans; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007915:Lepidoptera / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D051381:Rats; D019837:Ryanodine Receptor Calcium Release Channel / Q000187:drug effects*; D013329:Structure-Activity Relationship; D023382:Toxicity Tests, Acute; D015854:Up-Regulation / Q000187:drug effects; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D019837:Ryanodine Receptor Calcium Release Channel; D062367:ortho-Aminobenzoates; C517733:chlorantranilipole