Preproghrelin Leu72Met polymorphism in Chinese subjects with coronary artery disease and controls.
BACKGROUND
Ghrelin, a novel endogenous ligand for the growth hormone secretagogue receptor, is considered to exert a protective effect against atherosclerosis. The Leu72Met (+408C>A) polymorphic variant of the preproghrelin, the gene for the ghrelin precursor, has been linked to obesity, diabetes and metabolic syndrome. However, it is unclear whether this polymorphism is associated with coronary artery disease (CAD).


METHODS
We conducted a case-control study with 317 CAD patients and 323 controls to investigate the potential association of the Leu72Met polymorphism with the occurrence of CAD and CAD-related phenotypes in Chinese population.


RESULTS
No significant difference in the Leu72Met genotype frequency was observed between CAD patients and controls (P=NS). The Leu72Met polymorphism was not associated with hypertension, diabetes, dyslipidemia, the number of diseased vessels, plasma total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol or fasting glucose levels in CAD patients. However, among CAD patients, those with variant genotypes (Leu72Met and Met72Met) had lower BMI (24.4+/-0.3 kg/m(2)) than Leu72Leu carriers (25.4+/-0.2 kg/m(2), adjusted P=0.033).


CONCLUSIONS
Our data indicate that the preproghrelin Leu72Met polymorphism is not associated with CAD in Chinese population. However, the Leu72Met variant is associated with BMI among CAD patients.
Tang
Na-Ping
NP
Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, China.
Wang
Lian-Sheng
LS
Yang
Li
L
Gu
Hai-Juan
HJ
Zhu
Huai-Jun
HJ
Zhou
Bo
B
Sun
Qing-Min
QM
Cong
Ri-Hong
RH
Wang
Bin
B
D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D054439:Ghrelin / Q000235:genetics*; D006801:Humans; D007930:Leucine / Q000235:genetics*; D008055:Lipids / Q000097:blood; D008297:Male; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D011498:Protein Precursors / Q000235:genetics*
D001786:Blood Glucose; D054439:Ghrelin; D008055:Lipids; D011498:Protein Precursors; D008715:Methionine; D007930:Leucine