title: Trypanocidal tetrahydrofuran lignans from Peperomia blanda.
abstract: Five tetrahydrofuran lignans and two known flavones were isolated from the aerial parts of Peperomia blanda. The structures of the isolated lignans were elucidated by interpretation of their spectroscopic data, including by gHMQC and gHMBC. The relative and absolute configurations of the isolates were determined from NOESY interactions and optical properties, respectively. Four of the lignans were diastereomeric whilst one was of mixed biosynthetic origin. All but one of the lignans exhibited high in vitro trypanocidal activity when assayed against epimastigotes of Trypanosoma cruzi strain Y.
authors: Instituto de Química, Universidade Estadual Paulista, CP 355, 14800-900 Araraquara, SP, Brazil.
authors: Lidiane Gaspareto
authors: LG
authors: Felippe
authors: Debora Cristina
authors: DC
authors: Baldoqui
authors: Massuo Jorge
authors: MJ
authors: Kato
authors: Vanderlan da Silva
authors: Vda S
authors: Bolzani
authors: Elsie Franklin
authors: EF
authors: Guimarães
authors: Regina Maria Barreto
authors: RM
authors: Cicarelli
authors: Maysa
authors: M
authors: Furlan
mesh_terms: D000818:Animals; D005663:Furans / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D036941:Peperomia / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D005663:Furans; D017705:Lignans; D014344:Trypanocidal Agents; C018674:tetrahydrofuran