Vibrational energy relaxation of isotopically labeled amide I modes in cytochrome c: theoretical investigation of vibrational energy relaxation rates and pathways.
With use of a time-dependent perturbation theory, vibrational energy relaxation (VER) of isotopically labeled amide I modes in cytochrome c solvated with water is investigated. Contributions to the VER are decomposed into two contributions from the protein and water. The VER pathways are visualized by using radial and angular excitation functions for resonant normal modes. Key differences of VER among different amide I modes are demonstrated, leading to a detailed picture of the spatial anisotropy of the VER. The results support the experimental observation that amide I modes in proteins relax with subpicosecond time scales, while the relaxation mechanism turns out to be sensitive to the environment of the amide I mode.
Fujisaki
Hiroshi
H
Department of Chemistry, Boston University, Boston, MA 02215, USA. fujisaki@theochem.uni-frankfurt.de
Straub
John E
JE
D000577:Amides / Q000737:chemistry*; D045304:Cytochromes c / Q000737:chemistry*; D007554:Isotopes / Q000737:chemistry; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D014732:Vibration; D014867:Water / Q000737:chemistry
D000577:Amides; D007554:Isotopes; D014867:Water; D045304:Cytochromes c