Successful treatment of relapsing neuro-Sweet's disease with corticosteroid and dapsone combination therapy.
Sweet's disease with central nervous system involvement, tentatively named neuro-Sweet's disease, has rarely been reported. Although systemic corticosteroid therapy is highly effective for neurologic symptoms in neuro-Sweet's disease, relapse is common. Here, we describe the case of a 38-year-old Japanese man who presented with relapsing neuro-Sweet's disease that was successfully treated with a combination of corticosteroid and dapsone. Dapsone should be considered as a therapeutic option for neuro-Sweet's disease patients showing relapse.
Fukae
Jiro
J
Department of Neurology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka 410-2295, Japan.
Noda
Kazuyuki
K
Fujishima
Kenji
K
Wada
Ryo
R
Yoshiike
Takashi
T
Hattori
Nobutaka
N
Okuma
Yasuyuki
Y
D000284:Administration, Oral; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001706:Biopsy; D001921:Brain / Q000473:pathology; D003622:Dapsone / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D008775:Methylprednisolone / Q000008:administration & dosage*; D011239:Prednisolone / Q000008:administration & dosage*; D012008:Recurrence; D012867:Skin / Q000473:pathology; D016463:Sweet Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D003622:Dapsone; D011239:Prednisolone; D008775:Methylprednisolone