title: Evaluation of left ventricular diastolic functions in patients with frequent premature ventricular contractions from right ventricular outflow tract.
abstract: This study was sought to examine the effects of repetitive monomorphic premature ventricular contractions (PVCs) on left ventricular (LV) diastolic function. Thirty-three symptomatic patients (Study group, 10 males, mean age 40 +/- 8 years) with normal LV systolic function and repetitive PVCs originating from the right ventricular outflow tract (RVOT-PVCs) on 24-h Holter monitoring, and 30 healthy controls (Control group, 9 males, mean age 37 +/- 9 years) were enrolled in the study. None of the patients had structural heart disease. Diastolic function was assessed by echocardiographic mitral inflow pattern and tissue Doppler imaging. The study group displayed a lower E/A ratio, longer isovolumetric relaxation time (IVRT), and longer E-wave deceleration time (EDT). In the study group 13 patients showed impaired relaxation. While mean values of the systolic velocity (Sa), early diastolic velocity (Ea), and early/late diastolic velocity (Ea/Aa) ratio were significantly lower in the study group, the Aa velocity and E/Ea ratio were significantly higher. Ea velocity was <10 cm/s in 7 study patients. Mitral inflow pattern and Ea velocity was normal in all controls. Significant correlations were found between ventricular premature beats percentage and early to late transmitral flow velocity ratio, EDT, IVRT, Ea velocity, the Ea/Aa ratio, and the E/Ea ratio. In multivariate analysis, total PVC count and age were found to be independent predictors of impaired relaxation. These results suggest that repetitive monomorphic RVOT-PVCs lead to abnormalities of LV diastolic function that may contribute to clinical symptoms in patients with structurally normal hearts.
authors: Department of Cardiology, Türkiye Yuksek Ihtisas Hospital, Ankara, Turkey. topaloglus@yahoo.com
authors: Serkan
authors: S
authors: Topaloglu
authors: Dursun
authors: D
authors: Aras
authors: Kumral
authors: K
authors: Cagli
authors: Ali
authors: A
authors: Yildiz
authors: Goksel
authors: G
authors: Cagirci
authors: Serkan
authors: S
authors: Cay
authors: Emre Nuri
authors: EN
authors: Gunel
authors: Kazim
authors: K
authors: Baser
authors: Erkan
authors: E
authors: Baysal
authors: Ayca
authors: A
authors: Boyaci
authors: Sule
authors: S
authors: Korkmaz
mesh_terms: D000293:Adolescent; D000328:Adult; D002309:Cardiology / Q000379:methods*; D003971:Diastole; D004452:Echocardiography / Q000379:methods; D015150:Echocardiography, Doppler / Q000379:methods; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology; D015999:Multivariate Analysis; D015203:Reproducibility of Results; D018608:Ultrasonography, Doppler / Q000379:methods; D016277:Ventricular Function, Left; D018879:Ventricular Premature Complexes / Q000175:diagnosis* / Q000000981:diagnostic imaging