Julichrome Q6 glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp.
The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide ( 9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q 1.2 ( 7a), Q 1.5 ( 7b), and Q 3.5 ( 8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol ( 6a) and N-phenyl-beta-naphthylamine ( 10). The isomeric N-phenyl-alpha-naphthylamine ( 11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.
Shaaban
Khaled A
KA
Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Shaaban
Mohamed
M
Grün-Wollny
Iris
I
Maier
Armin
A
Fiebig
Heinz H
HH
Laatsch
Hartmut
H
D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000737:chemistry; D015081:2-Naphthylamine / Q000031:analogs & derivatives / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002708:Chlorella / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D015942:Factor VIIa; D005965:Glucuronates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D011994:Recombinant Proteins; D013302:Streptomyces / Q000737:chemistry*
D005965:Glucuronates; D009281:Naphthalenes; D011994:Recombinant Proteins; C524903:julichrome Q6 glucuronide; C011948:neozone; C005444:N-phenyl-1-naphthylamine; D015057:1-Naphthylamine; C103587:recombinant FVIIa; D015081:2-Naphthylamine; D015942:Factor VIIa