[Effects of cholinergic antagonists in stress].
Effects of methacine, hexamethonium and their combinations with neostigmine on activity of B-lymphocytes in various phases of immune response and development of stress ulcers induced in animals were studied. The drugs were found to modulate B-lymphocyte activity for 28 days and longer. By a water-immersion stress model it was shown that methacin is effective not only as m-cholinolytic but also as an immunoprophylactic drug reducing destructive changes in gastric mucosa. Injection of methacin 30 min before stress (block of m-cholinoreceptors) or 14 days before stress (maximal increase of B cell activity) results in 3-4-fold inhibition of ulcerogenesis in gastric mucosa.
Nezhinskaia
G I
GI
Losev
N A
NA
Sapronov
N S
NS
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009388:Neostigmine / Q000494:pharmacology; D010115:Oxyphenonium / Q000494:pharmacology; D010437:Peptic Ulcer / Q000209:etiology / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013315:Stress, Psychological / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D013997:Time Factors
D018680:Cholinergic Antagonists; D006584:Hexamethonium Compounds; D009388:Neostigmine; D010115:Oxyphenonium; C021628:benzohexonium