A new class of reverse signaling costimulators belongs to the TNF family.
Recent evidence shows that many molecules of the TNF family serve as counter-receptors, inducing costimulation through reverse signals in addition to delivering signals through their respective TNF receptors. In this review, we will discuss this new class of costimulators with a focus on the mechanism of costimulation transduced by reverse signaling through Fas ligand.
Sun
Mingyi
M
Department of Immunology, University of Washington, Seattle, WA 98195, USA.
Fink
Pamela J
PJ
D000818:Animals; D049109:Cell Proliferation; D003593:Cytoplasm / Q000378:metabolism; D053222:Fas Ligand Protein / Q000378:metabolism; D006801:Humans; D015398:Signal Transduction / Q000276:immunology*; D048069:Tumor Necrosis Factors / Q000145:classification / Q000276:immunology*
D053222:Fas Ligand Protein; D048069:Tumor Necrosis Factors