Dengue virus cross-reactive hemagglutination inhibition antibody responses in patients with primary dengue virus infection.
Acute and convalescent plasma samples were obtained from 101 confirmed primary dengue cases: 48 cases infected with dengue virus type 1, 10 cases with type 2, 42 cases with type 3 and one case with type 4. The hemagglutination inhibition (HI) titers of individual samples were at levels similar to each of the 4 dengue viruses at both the acute and convalescent stages, irrespective of the dengue virus that infected the patients. The results indicate that HI antibodies to dengue viruses are cross-reactive. When an HI test is used as a diagnostic test for dengue virus infection, the cross-reactive nature needs to be considered when interpreting the results.
Anantapreecha
Surapee
S
National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand. surapee@dmsc.moph.go.th
A-Nuegoonpipat
Atchareeya
A
Prakrong
Songthum
S
Chanama
Sumalee
S
Sa-Ngasang
Areerat
A
Sawanpanyalert
Pathom
P
Kurane
Ichiro
I
D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000276:immunology; D003429:Cross Reactions; D003715:Dengue / Q000097:blood / Q000276:immunology* / Q000821:virology; D003716:Dengue Virus / Q000276:immunology* / Q000302:isolation & purification; D006385:Hemagglutination Inhibition Tests / Q000379:methods*; D006801:Humans
D000914:Antibodies, Viral