title: Drosophila Ten-a is a maternal pair-rule and patterning gene.
abstract: The Ten-a gene of Drosophila melanogaster encodes several alternative variants of a full length member of the Odz/Tenm protein family. A number of Ten-a mutants created by inexact excisions of a resident P-element insertion are embryonic lethal, but show no pair-rule phenotype. In contrast, these mutants, and deficiencies removing Ten-a, do enhance the segmentation phenotype of a weak allele of the paralog gene odz (or Ten-m) to the odz amorphic phenotype. Germ line clone derived Ten-a(-) embryos display a pair-rule phenotype which phenocopies that of odz. Post segmentation eye patterning phenotypes of Ten-a mutants establish it as a pleiotropic patterning co-partner of odz.
authors: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
authors: Nadya
authors: N
authors: Rakovitsky
authors: Yosef
authors: Y
authors: Buganim
authors: Tomer
authors: T
authors: Swissa
authors: Yael
authors: Y
authors: Kinel-Tahan
authors: Shirly
authors: S
authors: Brenner
authors: Malkiel A
authors: MA
authors: Cohen
authors: Anna
authors: A
authors: Levine
authors: Ron
authors: R
authors: Wides
mesh_terms: D000483:Alleles; D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D019521:Body Patterning; D002970:Cleavage Stage, Ovum / Q000166:cytology; D002999:Clone Cells; D004251:DNA Transposable Elements; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000166:cytology; D005091:Exons / Q000235:genetics; D005123:Eye / Q000196:embryology / Q000648:ultrastructure; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D005854:Germ Cells; D007438:Introns / Q000235:genetics; D016254:Mutagenesis, Insertional; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D019063:Tenascin / Q000378:metabolism; D014158:Transcription, Genetic; D015053:Zygote
chemical_list: D004251:DNA Transposable Elements; D029721:Drosophila Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; C470835:Ten-a protein, Drosophila; C089140:Ten-m protein, Drosophila; D019063:Tenascin