Unsaturated phosphatidylethanolamine as effective synergist in combination with alpha-tocopherol.
The effects of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) on the oxidation of bonito oil triacylglycerol (TAG) were examined under the absence or presence of alpha-tocopherol. Synthesized PC or PE having saturated and unsaturated fatty acids in known position were used in this study. Unsaturated PC and PE promoted TAG oxidation under the absence of alpha-tocopherol. On the contrary, unsaturated PE showed synergistic antioxidant effect with alpha-tocopherol, while PC had little effect. The strongest synergistic effect was found by 1-palmitoyl (16:0, PA)-2-docosahexaenoyl (22:6n-3)-PE, followed by 1-PA-2-arachidonyl (20:4n-6)-PE, 1,2-dioleoyl (18:1n-9)-PE, and 1-PA-2-linoleoyl (18:2n-6)-PE, respectively.
Takenaka
Atsushi
A
Laboratory of Bio-functional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries Sciences, Hokkaido University, Hokodate, Japan.
Hosokawa
Masashi
M
Miyashita
Kazuo
K
D000975:Antioxidants / Q000494:pharmacology; D004281:Docosahexaenoic Acids / Q000138:chemical synthesis; D004338:Drug Combinations; D004357:Drug Synergism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D010084:Oxidation-Reduction; D010714:Phosphatidylethanolamines / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism*; D024502:alpha-Tocopherol / Q000494:pharmacology*
D000975:Antioxidants; D004338:Drug Combinations; D005231:Fatty Acids, Unsaturated; D010714:Phosphatidylethanolamines; D014280:Triglycerides; D004281:Docosahexaenoic Acids; C483858:phosphatidylethanolamine; D024502:alpha-Tocopherol