title: Peptide ligands for the melanin-concentrating hormone (MCH) receptor 1.
abstract: The melanin-concentrating hormone receptor 1 (MCH-1R) has been recognized as a receptor which mediates effects of the endogenous melanin-concentrating hormone (MCH) on appetite and body weight gain in rodents. In the last several years, a number of hMCH analogs have been designed which were potent and selective ligands for hMCH-1R. These peptidic agonists and antagonists have served as research tools in animal studies that showed a key role of the MCH-1R in the development of obesity and proved that MCH-1R antagonism can produce anti-obesity effects in rodents.
authors: Merck Research Laboratories, Department of Medicinal Chemistry, Rahway, NJ 07065, USA. maria_bednarek@merck.com
authors: Maria A
authors: MA
authors: Bednarek
mesh_terms: D000818:Animals; D006801:Humans; D007028:Hypothalamic Hormones / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D008543:Melanins / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D010907:Pituitary Hormones / Q000737:chemistry / Q000378:metabolism; D011979:Receptors, Pituitary Hormone / Q000819:agonists / Q000037:antagonists & inhibitors / Q000145:classification* / Q000378:metabolism*
chemical_list: D007028:Hypothalamic Hormones; D008024:Ligands; D008543:Melanins; D010455:Peptides; D010907:Pituitary Hormones; D011979:Receptors, Pituitary Hormone; C092274:melanin-concentrating hormone receptor; C019463:melanin-concentrating hormone