title: Convenient one-pot synthesis of multisubstituted tetrahydropyrimidines via catalyst-free multicomponent reactions.
abstract: A novel and convenient one-pot synthesis of multisubstituted pyrimidine analogues via multicomponent reactions is disclosed. This catalyst-free domino reaction proceeded smoothly in good to excellent yields and offered several other advantages including short reaction time, a simple experimental workup procedure, and no toxic byproduct. In addition, the obtained products in our experiments are interesting nitrogen heterocyclic molecules containing alpha- and beta-amino acid blocks.
authors: The College of Chemistry, South China University of Technology, Guangzhou 510640, PRC.
authors: Min
authors: M
authors: Zhang
authors: Huanfeng
authors: H
authors: Jiang
authors: Hailing
authors: H
authors: Liu
authors: Qiuhua
authors: Q
authors: Zhu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D011743:Pyrimidines; D009584:Nitrogen