[Molecular approach for development of new medicaments for chronic infections treatment].
Owing to the progress in cellular microbiology it has been evidently proved that inflammation induced by infectious agents forms the basis of many chronic conditions. Therefore a microbial infection can be considered as a triggering factor of such widespread and significant diseases as infertility, arthritis, atherosclerosis, asthma, gastritis, stomach ulcer and cancer, neurological syndromes and some oncological formations. Practically all pathogenic and conditionally pathogenic bacteria can induce chronic infections of different organs and tissues. It has been revealed that in spite of differences of clinical syndromes and participation of different bacteria in their induction the several general mechanisms of chronic infections are detected. Failure in chronic infections therapy is due to the absence of medicaments to eradicate persistent forms of pathogens. The development of new medicaments for chronic infections treatment should be based on the selection of new specific targets, influence on which would to inhibit the mechanism of chronic infections induction.
Zigangirova
N A
NA
Gintsburg
A L
AL
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D050197:Atherosclerosis / Q000209:etiology; D001327:Autoimmune Diseases / Q000209:etiology; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D018441:Biofilms / Q000254:growth & development; D002908:Chronic Disease; D003141:Communicable Diseases / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D015195:Drug Design; D005756:Gastritis / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D009369:Neoplasms / Q000209:etiology; D013276:Stomach Ulcer / Q000209:etiology
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents