A pigmented calcifying cystic odontogenic tumor associated with compound odontoma: a case report and review of literature.
BACKGROUND
Pigmented intraosseous odontogenic lesions are rare with only 47 reported cases in the English literature. Among them, pigmented calcifying cystic odontogenic tumor, formerly known as calcifying odontogenic cyst, is the most common lesion with 20 reported cases.


METHODS
A case of pigmented calcifying cystic odontogenic tumor associated with odontoma occurring at the mandibular canine-premolar region of a young Japanese boy is presented with radiographic, and histological findings. Special staining, electron microscopic study and immunohistochemical staining were also done to characterize the pigmentation.


RESULTS
The pigments in the lesion were confirmed to be melanin by Masson-Fontana staining and by transmission electron microscopy. The presence of dendritic melanocytes within the lesion was also demonstrated by S-100 immunostaining.


CONCLUSIONS
The present case report of pigmented calcifying cystic odontogenic tumor associated with odontoma features a comprehensive study on melanin and melanocytes, including histochemical, immunohistochemical and transmission electron microscopic findings.
Han
Phuu P
PP
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan. phuupwinthan@gmail.com
Nagatsuka
Hitoshi
H
Siar
Chong H
CH
Tsujigiwa
Hidetsugu
H
Gunduz
Mehmet
M
Tamamura
Ryo
R
Borkosky
Silvia S
SS
Katase
Naoki
N
Nagai
Noriyuki
N
D000293:Adolescent; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology*; D008543:Melanins / Q000032:analysis; D046529:Microscopy, Electron, Transmission; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D018333:Odontogenic Cyst, Calcifying / Q000473:pathology*; D009810:Odontoma / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis
D008543:Melanins; D009418:S100 Proteins