title: Interaction between sodium hypochlorite and chlorhexidine gluconate.
abstract: The combination of sodium hypochlorite (NaOCl) and chlorhexidine (CHX) results in the formation of a precipitate. The aim of this study was to determine the minimum concentration of NaOCl required to form a precipitate with 2.0% CHX. This was accomplished with a serial dilution technique. X-ray photon spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (TOF-SIMS) were used to qualify and quantify the precipitate. A color change and precipitate were induced in 2.0% CHX by 0.023% and 0.19% NaOCl, respectively. Both XPS and TOF-SIMS showed the presence of para-chloroaniline in an amount directly related to the concentration of NaOCl used. Until this precipitate is studied further, its formation should be avoided by removing the NaOCl before placing CHX into the canal.
authors: Department of Endodontics University of Toronto, Toronto, Ontario, Canada. bettina.basrani@dentistry.utoronto.ca
authors: Bettina R
authors: BR
authors: Basrani
authors: Sheela
authors: S
authors: Manek
authors: Rana N S
authors: RN
authors: Sodhi
authors: Edward
authors: E
authors: Fillery
authors: Aldo
authors: A
authors: Manzur
mesh_terms: D000814:Aniline Compounds; D011232:Chemical Precipitation; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D003116:Color; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004395:Dye Dilution Technique; D012388:Root Canal Irrigants / Q000008:administration & dosage* / Q000737:chemistry; D012973:Sodium Hypochlorite / Q000008:administration & dosage* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013052:Spectrometry, X-Ray Emission
chemical_list: D000814:Aniline Compounds; D012388:Root Canal Irrigants; D012973:Sodium Hypochlorite; C010882:chlorhexidine gluconate; D002710:Chlorhexidine; C004658:4-chloroaniline