Pro-convulsant effect of cefazolin sodium against pentylenetetrazol- or picrotoxin-induced convulsions in mice.
Cefazolin injection (3000 mg/kg, i.v.) in mice showed several behavioral excitations such as wild running, jumping, rolling, and finally undergoing severe convulsions followed by death. It's lower doses (500-2000 mg/kg, i.v.) were unable to produce any convulsions or behavioral excitations in mice. However, cefazolin (500 or 1000 mg/kg, i.v.) when administered before different doses of pentylenetetrazol (PTZ; 40 or 60 mg/kg, i.p.) or picrotoxin (PTX; 4 or 8 mg/kg, i.p.), it produced severe tonic-clonic convulsions in mice. The convulsions or behavioral excitations produced by 3000 mg/kg, i.v. cefazolin was also reversed by different doses of diazepam (0.5-2 mg/kg, i.p.) further proving the GABAergic modulatory effect of cefazolin. The results conclude the pro-convulsant action of cefazolin on PTZ- or PTX-induced convulsions, and further confirm the clinical reports.
Akula
Kiran Kumar
KK
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India.
Dhir
Ashish
A
Kulkarni
S K
SK
D000818:Animals; D000900:Anti-Bacterial Agents; D001522:Behavior, Animal / Q000187:drug effects; D002437:Cefazolin / Q000633:toxicity*; D003292:Convulsants / Q000633:toxicity; D058785:GABA-A Receptor Agonists; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010433:Pentylenetetrazole / Q000633:toxicity; D010852:Picrotoxin / Q000633:toxicity; D012640:Seizures / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D002437:Cefazolin; D003292:Convulsants; D058785:GABA-A Receptor Agonists; D010433:Pentylenetetrazole; D010852:Picrotoxin