title: Rifampicin-associated segmental necrotizing glomerulonephritis in staphylococcal endocarditis.
abstract: Segmental necrotising glomerulonephritis has been reported as complication of rifampicin therapy in patients receiving treatment for tuberculosis. Changing epidemiology of infections such as infective endocarditis (IE) has led to an increase in the use of rifampicin for Staphylococcal infections. We describe a case of a patient with Staphylococcal IE who developed acute renal failure secondary to a segmental necrotising glomerulonephritis while being treated with rifampicin, and review the literature regarding this complication of rifampicin therapy.
authors: Department of Renal Medicine, St Vincent's Hospital, Melbourne, Victoria, Australia. kate.wiggins@svhm.org.au
authors: Kathryn J
authors: KJ
authors: Wiggins
authors: Jason W
authors: JW
authors: Galanos
authors: Prue A
authors: PA
authors: Hill
authors: Kirsten V
authors: KV
authors: Scott
authors: Robyn G
authors: RG
authors: Langham
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000009:adverse effects* / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D006801:Humans; D009336:Necrosis; D012293:Rifampin / Q000009:adverse effects* / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus
chemical_list: D000904:Antibiotics, Antitubercular; D012293:Rifampin