COX-2 inhibitors can down-regulate in vivo antibody response against T-dependent antigens.
There are many studies demonstrating by different experimental models that non-steroidal antiinflammatory drugs (NSAIDs), also known as cyclooxygenase-2 (COX-2) inhibitors, can modulate immune response such as lymphoid cells differentiation and proliferation. There are experimental data which show that activated B cells can express mRNA COX-2, release prostaglandins (PGs) and produce immunoglobulins in PGs dependent manner. In this study, using different COX-2 inhibitors and applying personalized immunization scheme, we confirmed that it is possible to modulate in vivo antibody response against T cell dependent antigens, substantiating the importance of PGE2 and E prostanoid receptor (EP-R) in antibody generation. Our results point out the fact that we must be more careful when we apply vaccines containing T-cell dependent antigens, such as tetanus or diphteric anatoxin, to the patients under an intense antiinflammatory treatment.
Lupu
Andreea-Roxana
AR
NIRDMI Cantacuzino, Bucharest-Romania.
Cremer
Lidia
L
Durbacă
Steliana
S
Călugaru
Ana
A
Herold
Aurora
A
Kerek
F
F
Szegli
G
G
Radu
D L
DL
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology*; D015232:Dinoprostone / Q000378:metabolism; D004167:Diphtheria Toxin / Q000276:immunology* / Q000378:metabolism; D005620:Freund's Adjuvant; D007117:Immunization, Secondary; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*; D013744:Tetanus Toxin / Q000276:immunology* / Q000378:metabolism; D013745:Tetanus Toxoid / Q000276:immunology*; D051195:Toll-Like Receptor 2 / Q000276:immunology / Q000378:metabolism; D051197:Toll-Like Receptor 4 / Q000276:immunology / Q000378:metabolism
D000907:Antibodies, Bacterial; D052246:Cyclooxygenase 2 Inhibitors; D004167:Diphtheria Toxin; D008070:Lipopolysaccharides; D013744:Tetanus Toxin; D013745:Tetanus Toxoid; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D005620:Freund's Adjuvant; D015232:Dinoprostone