[The mechanism of DNA damage checkpoint control].
DNA damage caused by many factors may lead to missense mutation, deletion or illegal recombination. To maintain genomic integrity, cells have evolved complex surveillance mechanisms termed cell cycle checkpoint. DNA damage checkpoint composed of various checkpoint-related proteins can sense DNA damage and execute cell cycle arrest through different signaling transduction pathway involving protein kinase cascades, thereby allowing time for cells to repair the damaged DNA.
Guo
Yan-Hong
YH
Medical Research Center, Third Hospital of Peking University, Beijing 100083, China.
Zhu
Ying-Bao
YB
D000818:Animals; D059447:Cell Cycle Checkpoints / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D011494:Protein Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D018797:Cell Cycle Proteins; D011494:Protein Kinases