title: [Prophylactic effect of tropisetron hydrochloride against nausea and vomiting in patients receiving chemotherapy for hematological malignancies].
abstract: To establish the effectiveness of oral 5-HT(3) antagonist, oral 5 mg tropisetron was introduced in the 21 cases with hematological malignancies for the prevention of chemotherapy-induced nausea and vomiting. Nausea and vomiting did not develop in 81% of patients receiving the tropisetron in this study. The results suggested that oral tropisetron is effective for the control of acute, and to a lesser extent, delayed, nausea and vomiting. The drug enhanced patients' quality of life and reduced the clinical cost. In conclusion, tropisetron is effective for the prevention of chemotherapy-induced nausea and vomiting in treatment for hematological malignancies. It is suitable as first-line therapy for outpatients.
authors: Department of Hematology and Oncology, Kyoto Prefectural University of Medical Science Graduate School of Medical Science.
authors: Kenichi
authors: K
authors: Nomura
authors: Yoshiko
authors: Y
authors: Fujimoto
authors: Kyoko
authors: K
authors: Taniguchi
authors: Daisuke
authors: D
authors: Shimizu
authors: Masashi
authors: M
authors: Okamoto
authors: Kazuho
authors: K
authors: Shimura
authors: Yosuke
authors: Y
authors: Matsumoto
authors: Yuko
authors: Y
authors: Kanbayashi
authors: Sawako
authors: S
authors: Tanaka
authors: Hiroto
authors: H
authors: Kaneko
authors: Shigeo
authors: S
authors: Horiike
authors: Chihiro
authors: C
authors: Shimazaki
authors: Shohei
authors: S
authors: Yokota
authors: Masafumi
authors: M
authors: Taniwaki
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000008:administration & dosage*; D005260:Female; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D000077526:Tropisetron; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D007211:Indoles; D000077526:Tropisetron