title: Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder.
abstract: BACKGROUND
  Obsessive-Compulsive Disorder (OCD) is a debilitating illness with putative glutamatergic abnormalities. Two separate proximal haplotypes in the glutamate transporter gene, SLC1A1, were recently reported to be associated with OCD among males, but replication is required.
  
  
  OBJECTIVE
  This study examines SLC1A1 as a candidate gene for OCD and explores gender influences. It was hypothesized that a significant association between SLC1A1 and OCD would be replicated in an independent sample of males but not females.
  
  
  METHODS
  Family-based association candidate gene study.
  
  
  METHODS
  Participants were recruited from tertiary care OCD specialty clinics.
  
  
  METHODS
  OCD probands and their first degree relatives.
  
  
  METHODS
  Association of OCD with genotypes of single nucleotide polymorphism (SNP) markers and related haplotypes.
  
  
  RESULTS
  Association between OCD and the three-marker haplotype rs12682807/ rs2072657/ rs301430, with overtransmission of A/T/T, was observed in both genders combined (global P = 0.0015) and in males (global P = 0.0031). Single-marker associations with OCD in the region (rs3780412 and rs2228622) demonstrated modest significance (permuted P = 0.045).
  
  
  CONCLUSIONS
  This study identifies a significant association between the SLC1A1 glutamate transporter gene and OCD in a haplotype overlapping with that recently reported.
authors: Psychiatric Neurodevelopmental and Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
authors: S Evelyn
authors: SE
authors: Stewart
authors: Jesen A
authors: JA
authors: Fagerness
authors: Jill
authors: J
authors: Platko
authors: Jordan W
authors: JW
authors: Smoller
authors: Jeremiah M
authors: JM
authors: Scharf
authors: Cornelia
authors: C
authors: Illmann
authors: Eric
authors: E
authors: Jenike
authors: Nadia
authors: N
authors: Chabane
authors: Marion
authors: M
authors: Leboyer
authors: Richard
authors: R
authors: Delorme
authors: Michael A
authors: MA
authors: Jenike
authors: David L
authors: DL
authors: Pauls
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D017668:Age of Onset; D002648:Child; D002874:Chromosome Mapping; D050580:Excitatory Amino Acid Transporter 3 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017678:Sex Distribution
chemical_list: D050580:Excitatory Amino Acid Transporter 3; C493400:SLC1A1 protein, human