Cryptadines A and B, novel C27N3-type pentacyclic alkaloids from Lycopodium cryptomerinum.
Two novel C(27)N(3)-type Lycopodium alkaloids, cryptadines A (1) and B (2) consisting of two octahydroquinoline rings (C(11)N) and a piperidine ring (C(5)N), have been isolated from the club moss Lycopodium cryptomerinum, and their structures and relative stereochemistry were elucidated on the basis of spectroscopic data, chemical transformations, and computational methods. Cryptadines A (1) and B (2) exhibited an inhibitory activity against acetylcholinesterase.
Koyama
Koichiro
K
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
Hirasawa
Yusuke
Y
Kobayashi
Jun'ichi
J
Morita
Hiroshi
H
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D003198:Computer Simulation; D003500:Cyclization; D032502:Lycopodium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification; D011804:Quinolines / Q000737:chemistry* / Q000302:isolation & purification
D000470:Alkaloids; D010880:Piperidines; D011804:Quinolines; C526499:cryptadine A; C526498:cryptadine B