title: Innovative proteomic approaches for cancer biomarker discovery.
abstract: Substantial technological advances in proteomics and related computational science have been made in the past few years. These advances overcome in part the complexity and heterogeneity of the human proteome, permitting quantitative analysis and identification of protein changes associated with tumor development. Here, we discuss some of these advances that are uncovering new cancer biomarkers that have potential to detect cancer at early and curable stages and address remaining challenges.
authors: Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors: Vitor
authors: V
authors: Faca
authors: Alexei
authors: A
authors: Krasnoselsky
authors: Samir
authors: S
authors: Hanash
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D020869:Gene Expression Profiling / Q000639:trends*; D006801:Humans; D007118:Immunoassay / Q000639:trends*; D009363:Neoplasm Proteins / Q000032:analysis*; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis / Q000639:trends; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000639:trends*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D020543:Proteome