title: A more serine way to die: defining the characteristics of serine protease-mediated cell death cascades.
abstract: The morphological features observed by Kerr, Wylie and Currie in 1972 define apoptosis, necrosis and autophagy. An appreciable number of alternative systems do not fall neatly under these categories, warranting a review of alternative proteolytic machinery and its contribution to cell death. This review aims to pinpoint key molecular features of serine protease-mediated pro-apoptotic signalling. The profile created will contribute to a standard set of biochemical criteria that can serve in differentiating within cell death subtypes.
authors: National Centre for Biomedical and Engineering Science, National University of Ireland, Galway, Ireland.
authors: A R
authors: AR
authors: O'Connell
authors: C
authors: C
authors: Stenson-Cox
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D016923:Cell Death / Q000502:physiology*; D053804:Granzymes / Q000378:metabolism; D000074923:High-Temperature Requirement A Serine Peptidase 2; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D012697:Serine Endopeptidases / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins; C108734:AP24 apoptotic protease; D053804:Granzymes; D012697:Serine Endopeptidases; D000074923:High-Temperature Requirement A Serine Peptidase 2; D014568:Urokinase-Type Plasminogen Activator