title: Assessing the impact of pulmonary rehabilitation on functional status in COPD.
abstract: BACKGROUND
  The optimal way of assessing the impact of pulmonary rehabilitation on functional status in chronic obstructive pulmonary disease (COPD) is currently unknown. The minimal clinically important difference for the constant work rate cycling exercise test also needs to be investigated to facilitate its interpretation. A study was undertaken to evaluate the changes in the 6-min walking test and in the constant work rate cycle endurance test immediately following and 1 year after pulmonary rehabilitation, together with the importance of these changes in terms of health status in patients with COPD.
  
  
  METHODS
  Patients with COPD of mean (SD) age 65 (8) years and mean (SD) forced expiratory volume in 1 s (FEV1) 45 (15)% predicted were recruited from a multicentre prospective cohort study and evaluated at baseline, immediately after a pulmonary rehabilitation programme (n = 157) and at 1 year (n = 106). The 6-min walking test and the cycle endurance test were performed at each evaluation. Health status was evaluated with the St George Respiratory Questionnaire.
  
  
  RESULTS
  Following pulmonary rehabilitation, cycle endurance time increased (198 (352) s, p<0.001) and stayed over baseline values at 1 year (p<0.001). The 6-min walking distance also showed improvements following rehabilitation (25 (52) m, p<0.001) but returned to baseline values at the 1-year follow-up. Changes in cycle endurance time were more closely associated with changes in health status than with the 6-min walking test. An improvement of 100-200 s in the cycle endurance time was associated with clinically meaningful changes in the St George Respiratory Questionnaire scores.
  
  
  CONCLUSIONS
  The cycle endurance test was more responsive than the 6-min walking test in detecting improvement in exercise tolerance following pulmonary rehabilitation, and was also better correlated with improvements in health status. An improvement in the cycle endurance time of 100-200 s appeared to be clinically meaningful.
authors: Centre de Recherche, Hôpital Laval, Institut universitaire de cardiologie et de pneumologie de l'Université Laval, Quebec, Canada.
authors: L
authors: L
authors: Laviolette
authors: J
authors: J
authors: Bourbeau
authors: S
authors: S
authors: Bernard
authors: Y
authors: Y
authors: Lacasse
authors: V
authors: V
authors: Pepin
authors: M-J
authors: MJ
authors: Breton
authors: M
authors: M
authors: Baltzan
authors: M
authors: M
authors: Rouleau
authors: F
authors: F
authors: Maltais
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001642:Bicycling / Q000502:physiology; D015331:Cohort Studies; D005080:Exercise Test / Q000379:methods* / Q000592:standards; D017079:Exercise Tolerance / Q000502:physiology*; D005541:Forced Expiratory Volume / Q000502:physiology; D006304:Health Status; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology / Q000534:rehabilitation*; D011788:Quality of Life; D016138:Walking / Q000502:physiology