Technology insight: Innovative options for end-stage renal disease--from kidney refurbishment to artificial kidney.
The steadily growing number of patients with chronic kidney disease who will eventually develop end-stage renal disease, together with the qualitative limitations of currently available renal replacement therapies, have triggered the exploration of innovative strategies for renal replacement therapy and for salvage of renal function. Currently, new hemodialysis modalities and membranes are being used with the aim of increasing clearance of uremic toxins to afford better metabolic control. In addition to these conventional approaches, there are four innovative potential solutions to the problem of replacing renal function when kidneys fail. The first is a small, implantable device with the potential to be supplemented with human cells ('artificial kidney'). The second involves restoration of the damaged kidney by harnessing recent advances in stem-cell technology and knowledge of developmental programing ('refurbished kidney'). The third is (partially) growing a kidney in vitro with the use of therapeutic cloning ('cultured kidney'). The fourth innovative solution involves the use of other organs to replace various renal functions ('distributed kidney'). In this article we review the efforts that have been made to improve renal replacement therapies, and explore innovative approaches. We will not cover all potential solutions in detail. Rather, we aim to indicate directions of future endeavor and arouse enthusiasm in clinicians and scientists for exploration of these exciting avenues.
Braam
Branko
B
Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Canada. branko.braam@ualberta.ca
Verhaar
Marianne C
MC
Blankestijn
Peter
P
Boer
Walther H
WH
Joles
Jaap A
JA
D000818:Animals; D053595:Embryonic Stem Cells / Q000637:transplantation; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D016030:Kidney Transplantation; D007688:Kidneys, Artificial; D006435:Renal Dialysis; D033581:Stem Cell Transplantation; D023822:Tissue Engineering; D014183:Transplantation, Heterologous