No association of the -105 promoter polymorphism of the selenoprotein S encoding gene SEPS1 with cerebrovascular disease.
A common pro-inflammatory promoter variant of the selenoprotein S encoding gene (SEPS1) was studied in young stroke patients from Italy and Germany and in healthy control subjects. The -105A-allele was found in 56 of 205 (27.3%) patients with ischemic stroke IS because of a spontaneous cervical artery dissection (CAD), and in 69 of 295 (23.4%) patients <50 years with IS of non-CAD origin. The SEPS -105A promoter variant was detected in 87 of 393 healthy control subjects (22.1%) and in 11 of 55 CAD patients without IS (20%). The non-significant differences of SEPS1 allele frequencies between disease groups and healthy controls suggest that the SEPS1 -105A allele is not a major-risk factor for stroke.
Hyrenbach
S
S
Department of Neurology, University of Heidelberg, Germany.
Pezzini
A
A
del Zotto
E
E
Giossi
A
A
Lichy
C
C
Kloss
M
M
Werner
I
I
Padovani
A
A
Brandt
T
T
Grond-Ginsbach
C
C
D000328:Adult; D000483:Alleles; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D051140:Selenoproteins / Q000235:genetics*
D008565:Membrane Proteins; C487710:SELENOS protein, human; D051140:Selenoproteins