Mucoadhesive and elastic films based on blends of chitosan and hydroxyethylcellulose.
Mucoadhesive polymeric films have been prepared based on blends of chitosan and hydroxyethylcellulose. The blends have been characterized by IR spectroscopy, DSC, WAXD, TGA, SEM, and mechanical testing. It is demonstrated that the mechanical properties of chitosan are improved significantly upon blending with hydroxyethylcellulose. An increase in hydroxyethylcellulose content in the blends makes the materials more elastic. The thermal treatment of the blends at 100 degrees C leads to partial cross-linking of the polymers and formation of water-insoluble but swellable materials. The adhesion of the films towards porcine buccal mucosa decreases with increasing hydroxyethylcellulose content in the blends.
Luo
Kun
K
Shanghai University, Department of Polymer Materials, 20 Chengzhong Street, Jiading, Shanghai, 201800, China.
Yin
Jingbo
J
Khutoryanskaya
Olga V
OV
Khutoryanskiy
Vitaliy V
VV
D000818:Animals; D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004548:Elasticity; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009061:Mouth Mucosa / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D034421:Sus scrofa; D014014:Tissue Adhesives / Q000138:chemical synthesis* / Q000378:metabolism; D014961:X-Ray Diffraction
D014014:Tissue Adhesives; D002482:Cellulose; C002283:hydroxyethylcellulose; D048271:Chitosan