Actions and mode of actions of FGF19 subfamily members.
Fibroblast growth factors (FGFs) are humoral factors with diverse biological functions. While most FGFs were shown to work as local factors regulating cell growth and differentiation, recent investigations indicated that FGF19 subfamily members, FGF15/19, FGF21 and FGF23 work as systemic factors. FGF15/19 produced by intestine inhibits bile acid synthesis and FGF21from liver is involved in carbohydrate and lipid metabolism. In addition, FGF23 was shown to be produced by bone and regulate phosphate and vitamin D metabolism. Furthermore, these FGFs require klotho or betaklotho for their actions in addition to canonical FGF receptors. It is possible that these FGFs together with their receptor systems might be targets for novel therapeutic measures in the future.
Fukumoto
Seiji
S
Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital, Japan.
D000818:Animals; D053098:Familial Hypophosphatemic Rickets / Q000209:etiology / Q000235:genetics; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D005810:Multigene Family / Q000502:physiology; D010018:Osteomalacia / Q000209:etiology / Q000235:genetics
C117476:FGF19 protein, human; C000717427:FGF23 protein, human; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23