Growth hormone receptor; mechanism of action.
The growth hormone receptor has been an archetype for ligand-induced receptor dimerisation in cytokine receptor signalling. However, we now know that it exists as a constitutive dimer and is activated by a reorganisation of receptor subunits as a result of asymmetric placement of two receptor binding sites on the hormone monomer. This review highlights several topics including: current models of receptor activation; recent advances in the understanding of GH signalling demonstrating that ligand-induced signalling activates Src/ERK pathway in parallel to the classical JAK2-STAT5 signalling; and the nuclear localised growth hormone receptor correlates with high proliferation status and carcinogenesis.
Brooks
Andrew J
AJ
Institute for Molecular Bioscience, and School of Biomedical Sciences, University of Queensland, St Lucia, Queensland 4072, Australia. a.brooks@imb.uq.edu.au
Wooh
Jong Wei
JW
Tunny
Kathryn A
KA
Waters
Michael J
MJ
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D021381:Protein Transport; D011986:Receptors, Somatotropin / Q000737:chemistry / Q000378:metabolism*
D011986:Receptors, Somatotropin