[Effects of allicin on changes of hemorheology in focal cerebral ischemia-reperfusion injury].
OBJECTIVE
To explore the effects of allicin on the changes of hemorheology in focal cerebral ischemia-reperfusion injury in rats.


METHODS
Middle cerebral artery occlusion (MCAO) was used to make focal cerebral ischemia-reperfusion model by intravascular nylon filament occlusion. The protective effects of allicin at different doses were evaluated by investigating neurological function score, infarction volume and water content of brain. The changes of blood rheology were detected.


RESULTS
Compared with model group, allicin (15, 25 mg x kg(-1)) increased the neurological function score and decreased the water content and infarction volume of brain in rats. Allicin (15, 25 mg x kg(-1)) inhibited the increasing of the blood viscosity, high shear rate reduced viscosity, high shear relative reduced viscosity and low shear relative reduced viscosity.


CONCLUSIONS
Allicin has protective effects on cerebral ischemia-reperfusion injuries. The mechanism may be related to inhibit the increasing of hemorheology.
Li
Chun-yan
CY
Northeast Agricultural University, Harbin 150001, China.
Cheng
Xiao-song
XS
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D004220:Disulfides; D005737:Garlic / Q000737:chemistry*; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D008297:Male; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood* / Q000209:etiology / Q000473:pathology; D013441:Sulfinic Acids / Q000302:isolation & purification / Q000494:pharmacology*
D004220:Disulfides; D018696:Neuroprotective Agents; D013441:Sulfinic Acids; C006452:allicin