title: Ozone modifies associations between temperature and cardiovascular mortality: analysis of the NMMAPS data.
abstract: OBJECTIVE
  Both ambient ozone and temperature are associated with human health. However, few data are available on whether ozone modifies temperature effects. This study aims to explore whether ozone modified associations between maximum temperature and cardiovascular mortality in the USA.
  
  
  METHODS
  The authors obtained data from the US National Morbidity, Mortality, and Air Pollution Study (NMMAPS) website. They used two time-series Poisson regression models (a response surface model and a stratification model) to examine whether ozone modified associations between maximum temperature and cardiovascular mortality (CVM) in 95 large US communities during 1987-2000 in summer (June to September). Bayesian meta-analysis was used to pool estimates in each community.
  
  
  RESULTS
  The response surface model was used to examine the joint effects of temperature and ozone on CVM in summer. Results indicate that ozone positively modified the temperature-CVM associations across the different regions. The stratification model quantified the temperature-CVM associations across different levels of ozone. Results show that in general the higher the ozone concentration, the stronger the temperature-CVM associations across the communities. A 10 degrees C increase in temperature on the same day was associated with an increase in CVM by 1.17% and 8.31% for the lowest and highest level of ozone concentrations in all communities, respectively.
  
  
  CONCLUSIONS
  Ozone modified temperature effects in different regions in the USA. It is important to evaluate the modifying role of ozone when estimating temperature-related health impacts and to further investigate the reasons behind the regional variability and mechanism for the interaction between temperature and ozone.
authors: Department of Epidemiology, School of Medicine, University of California, 100 Theory Drive, Suite 100, Irvine, CA 92697-7555, USA. rencizao@yahoo.com
authors: C
authors: C
authors: Ren
authors: G M
authors: GM
authors: Williams
authors: L
authors: L
authors: Morawska
authors: K
authors: K
authors: Mengersen
authors: S
authors: S
authors: Tong
mesh_terms: D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000032:analysis* / Q000633:toxicity; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000401:mortality*; D004784:Environmental Monitoring / Q000379:methods; D062665:Epidemiological Monitoring; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010083:Oxidants, Photochemical / Q000032:analysis / Q000633:toxicity; D010126:Ozone / Q000032:analysis* / Q000633:toxicity; D012621:Seasons; D013696:Temperature; D014481:United States / Q000453:epidemiology; D014504:Urban Health / Q000706:statistics & numerical data; D014887:Weather
chemical_list: D000393:Air Pollutants; D010083:Oxidants, Photochemical; D010126:Ozone