title: Macular function in eyes with early age-related macular degeneration with or without contralateral late age-related macular degeneration.
abstract: OBJECTIVE
  To evaluate psychophysical and electrophysiologic responses in eyes with early age-related macular degeneration (AMD) without a decrease in visual acuity and with or without late AMD in the fellow eye.
  
  
  METHODS
  Fifteen patients (mean age: 67.9 +/- 7.20 years) with early AMD in both eyes (AMD1 group, 15 eyes) and 15 patients (mean age: 71.40 +/- 7.06 years) with early AMD in one eye and late AMD in the fellow eye (AMD2 group, 15 eyes) were enrolled. They were compared to 15 age-similar normal control subjects. LogMAR visual acuity (VA), macular sensitivity by MP-1 microperimetry, and multifocal electroretinograms (mfERG) were assessed in control, AMD1, and AMD2 eyes. mfERG response amplitude density (RAD, nV/deg2) of the N1-P1 component of first order binary kernels was measured.
  
  
  RESULTS
  When compared to controls, AMD1 and AMD2 eyes showed a significant (analysis of variance, P < 0.01) decrease in MP-1 microperimetry assessed in the 0-2.5 and 2.5-5 degrees of the macula, significantly correlated (Pearson test, P < 0.01) to the corresponding significant decrease (P < 0.01) in mfERG N1-P1 RADs assessed in the 0-2.5 and 2.5-5 degrees. In AMD1 and AMD2 eyes, VA and mfERG N1-P1 RADs assessed in the 5-20 degrees were similar (P > 0.01) to controls. VA, MP-1, and mfERG values were not significantly different in AMD1 and AMD2 eyes.
  
  
  CONCLUSIONS
  In eyes with early AMD there is a dysfunction of preganglionic elements in the central 0-5 retinal degrees detectable by mfERG or MP-1 microperimetry. This impairment is not further influenced by the presence of late AMD in the fellow eye.
authors: Fondazione per l'Oftalmologia G B Bietti-IRCCS, Rome, Italy. vparisi@tin.it
authors: Vincenzo
authors: V
authors: Parisi
authors: Loredana
authors: L
authors: Perillo
authors: Massimiliano
authors: M
authors: Tedeschi
authors: Cecilia
authors: C
authors: Scassa
authors: Geltrude
authors: G
authors: Gallinaro
authors: Nicoletta
authors: N
authors: Capaldo
authors: Monica
authors: M
authors: Varano
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004594:Electrophysiology; D004596:Electroretinography; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000503:physiopathology*; D008268:Macular Degeneration / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011603:Psychophysiology; D014786:Vision Disorders / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*