title: Use of everolimus as a rescue immunosuppressive therapy in liver transplant patients with neoplasms.
abstract: Everolimus is a new immunosuppressant with antitumoral properties and few side effects, but limited use in liver transplantation. The aim of the present study was to evaluate the effect on survival and safety of everolimus in post liver transplantation neoplasms in a single center. Ten liver transplant recipients with a posttransplant diagnosis of neoplasm received everolimus during a median of 12.7 (5.5-27.5) months; median survival was 21.3 (7.5-40.5) months. The probability of survival of everolimus group was significantly greater than the observed in a historical cohort of 14 liver recipients with comparable tumors who did not receive everolimus (100%, 90%, 72% vs. 50%, 29%, 14%) at 6, 12, and 24 months, respectively (HR=4.6, 95% confidence interval: 1.3-16.4; P=0.008). During everolimus therapy no patients showed rejection. Renal function improved in three patients. Furthermore, severe adverse effects and infections were infrequent. In summary, everolimus seems safe for liver transplant recipients with cancer and may improve short-term survival, but further studies are needed to determine long-term benefits and safety.
authors: Servicio de Aparato Digestivo, Unidad de Trasplante Hepático, CiberEHD, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Judith
authors: J
authors: Gomez-Camarero
authors: Magdalena
authors: M
authors: Salcedo
authors: Diego
authors: D
authors: Rincon
authors: Oreste
authors: O
authors: Lo Iacono
authors: Cristina
authors: C
authors: Ripoll
authors: Ana
authors: A
authors: Hernando
authors: Cecilia
authors: C
authors: Sanz
authors: Gerardo
authors: G
authors: Clemente
authors: Rafael
authors: R
authors: Bañares
mesh_terms: D000328:Adult; D000368:Aged; D000068338:Everolimus; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008107:Liver Diseases / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000401:mortality; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016019:Survival Analysis
chemical_list: D007166:Immunosuppressive Agents; D000068338:Everolimus; D020123:Sirolimus