title: Pneumonia caused by Candida krusei and Candida glabrata in a patient with chronic myeloid leukemia receiving imatinib mesylate treatment.
abstract: In this report we describe a patient suffering from chronic myeloid leukemia (CML), who was treated for 4.5 years with imatinib and developed pneumonia caused by two Candida species, i.e., C. krusei and C. glabrata. The patient was in complete hematologic remission and molecular analyses did not display the presence of TLR2-R752Q, TLR4-D299G and TLR4-T399I polymorphisms that may predispose individuals to fungal infections. This case report indicates that in some patients, as previously observed, the long-term administration of targeted therapy might affect immunity and predispose patients to opportunistic and life-threatening fungal infections.
authors: Department of Immunology and Histocompatibility, University of Thessaly Medical School, Larissa, Greece. speletas@otenet.gr
authors: Matthaios
authors: M
authors: Speletas
authors: Timoleon-Achilleas
authors: TA
authors: Vyzantiadis
authors: Fani
authors: F
authors: Kalala
authors: Dimitrios
authors: D
authors: Plastiras
authors: Kyriaki
authors: K
authors: Kokoviadou
authors: Antonios
authors: A
authors: Antoniadis
authors: Ioannis
authors: I
authors: Korantzis
mesh_terms: D000368:Aged; D001549:Benzamides; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000235:genetics / Q000382:microbiology*; D006801:Humans; D000068877:Imatinib Mesylate; D007951:Leukemia, Myeloid / Q000150:complications* / Q000188:drug therapy* / Q000235:genetics; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D009894:Opportunistic Infections / Q000235:genetics / Q000382:microbiology; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use; D011014:Pneumonia / Q000235:genetics / Q000382:microbiology*; D011110:Polymorphism, Genetic; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D011859:Radiography; D051195:Toll-Like Receptor 2 / Q000235:genetics; D051197:Toll-Like Receptor 4 / Q000235:genetics
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D000068877:Imatinib Mesylate