title: Cytokines, pregnancy, and bacterial vaginosis: comparison of levels of cervical cytokines in pregnant and nonpregnant women with bacterial vaginosis.
abstract: BACKGROUND
  Pregnancy has been considered to be a time of relative immune compromise. Lower-genital-tract immune response appears to be influenced by pregnancy. The objective of this study was to compare, in pregnant versus nonpregnant women, endocervical proinflammatory-cytokine expression in response to bacterial vaginosis.
  
  
  METHODS
  Endocervical levels of interleukin (IL)-1 beta , IL-6, and IL-8 in 99 pregnant and 99 nonpregnant women, all with bacterial vaginosis and without concurrent sexually transmitted infections, were assessed by ELISA. Vaginal flora was characterized on the basis of quantitative vaginal cultures.
  
  
  RESULTS
  Women in the 2 groups differed with respect to smoking status and microbiological constituents responsible for bacterial vaginosis. When the data were stratified by these potential confounders, the levels of all 3 proinflammatory endocervical cytokines were significantly higher in pregnant women than in nonpregnant women.
  
  
  CONCLUSIONS
  The proinflammatory cytokine milieu in the cervix is enhanced in pregnant women with bacterial vaginosis, compared with that in nonpregnant women. The notion of pregnancy as an immune-compromised state may be anatomically compartment specific.
authors.affiliation: University of Pittsburgh, Magee-Womens Hospital, Pittsburgh, PA 15213, USA. rbeigi@mail.magee.edu
authors.forename: Richard H
authors.initials: RH
authors.lastname: Beigi
authors.forename: Mark H
authors.initials: MH
authors.lastname: Yudin
authors.forename: Lisa
authors.initials: L
authors.lastname: Cosentino
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Meyn
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Hillier
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000378:metabolism*; D016585:Vaginosis, Bacterial / Q000378:metabolism*
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8