Deficiency in monocyte chemoattractant protein-1 modifies lipid and glucose metabolism.
We describe the effect of MCP-1 deficiency in mice rendered hyperlipemic by the concomitant ablation of the LDL receptor. The MCP-1(-/-)LDLr(-/-) mice in comparison with LDLr(-/-) mice showed a decreased lipoprotein clearance, derangements in free fatty acids delivery and less glucose tolerance when fed a regular chow, and they showed a partial resistance to alterations in glucose and lipid metabolism induced by dietary fat and cholesterol. They also were less prone to the development of diet-induced obesity. Our results suggest that the role of MCP-1 in metabolism is relevant and that, although new hidden complexities are evident, the function of MCP-1/CCL2 extends far beyond the monocyte chemoattractant effect. Therefore, the regulatory mechanisms influenced by MCP-1 should be fully ascertained to understand the metabolic consequences of inflammation and before considering MCP-1 as a therapeutic target.
Rull
Anna
A
Centre de Recerca Biomèdica, Institut de Recerca en Ciències de la Salut (IRCIS), Hospital Universitari de Sant Joan, C/. Sant Joan s/n, 43201-Reus, Spain.
Escolà-Gil
Joan Carles
JC
Julve
Josep
J
Rotllan
Noemí
N
Calpe-Berdiel
Laura
L
Coll
Blai
B
Aragonès
Gerard
G
Marsillach
Judit
J
Alonso-Villaverde
Carlos
C
Camps
Jordi
J
Blanco-Vaca
Francisco
F
Joven
Jorge
J
D000818:Animals; D018932:Chemokine CCL2 / Q000235:genetics / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D004032:Diet; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000737:chemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011973:Receptors, LDL / Q000235:genetics / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
C491768:Ccl2 protein, mouse; D018932:Chemokine CCL2; D007328:Insulin; D011973:Receptors, LDL; D014280:Triglycerides; D002784:Cholesterol; D005947:Glucose