The ups and downs of neural progenitors: Cep120 and TACCs control interkinetic nuclear migration.
The nuclei of dividing neural progenitors undergo a cell-cycle-dependent change in position along the apico-basal axis known as interkinetic nuclear migration (INM). The functional relationship between INM and the mode of division of neural progenitors remains elusive, in part because its regulation at the molecular level is poorly understood. In this issue of Neuron, Xie et al. identify two centrosomal proteins (Cep120 and TACCs) regulating the INM of cortical neural progenitors.
Guerrier
Sabrice
S
Neuroscience Center, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7250, USA.
Polleux
Franck
F
D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013234:Stem Cells / Q000378:metabolism*
D018797:Cell Cycle Proteins; D008869:Microtubule-Associated Proteins