title: High interleukin-10 production is associated with anti-acetylcholine receptor antibody production and treatment response in juvenile myasthenia gravis.
abstract: To investigate the significance of humoral immunological factors in juvenile myasthenia gravis (JMG) patients, 11 children with JMG (age of onset between 2 and 13 years) and 8 healthy controls were enrolled. Plasma IL-2, IL-10, IFN-gamma, TNF-alpha, complement factor C3, C4, and C1q levels were measured by ELISA. IL-2, IL-10, TNF-alpha, C3, and C4 levels were significantly elevated in the patient group. Moreover, plasma IL-10 levels were associated with the presence of anti-AChR antibody and response to treatment suggesting a critical role for IL-10 in JMG pathogenesis.
authors.affiliation: Istanbul Medical Faculty, Department of Neurology Division of Child Neurology, Istanbul University, Capa, Istanbul, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Yapici
authors.forename: E
authors.initials: E
authors.lastname: Tüzün
authors.forename: V
authors.initials: V
authors.lastname: Altunayoğlu
authors.forename: A
authors.initials: A
authors.lastname: Erdoğan
authors.forename: M
authors.initials: M
authors.lastname: Eraksoy
mesh_terms: D000906:Antibodies / Q000097:blood*; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D009157:Myasthenia Gravis / Q000097:blood / Q000276:immunology* / Q000628:therapy*; D011950:Receptors, Cholinergic / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000906:Antibodies; D003176:Complement C3; D003181:Complement C4; D007376:Interleukin-2; D011950:Receptors, Cholinergic; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10