title: Comparison of three instrumental methods for the objective evaluation of radiotherapy induced erythema in breast cancer patients and a study of the effect of skin lotions.
abstract: A non-blinded three armed study of the effect of Aloe vera, Essex and no lotion on erythema was performed. The erythema is an effect of radiotherapy treatment in breast cancer patients. The study required testing of objective methods for measuring the erythema. The chosen experimental methods were Near Infrared Spectroscopy, Laser Doppler Imaging and Digital Colour Photography. The experimental setup was made in such a way that in parallel with testing the effect of the lotions there was also a test of the sensitivity of the instruments. Fifty women were selected consecutively to participate in the study. They were all subjected to treatment with high-energy electrons (9-20 MeV) after mastectomy, 2 Gy/day to a total dose of 50 Gy. Measurements were performed before the start of radiotherapy and thereafter once a week during the course of treatment. Aloe vera and Essex lotion were applied twice every radiation day in selected sites. The increase in skin redness could be monitored with all techniques with a detection limit of 8 Gy for Digital Colour Photography and Near Infrared Spectroscopy and 18 Gy for Laser Doppler Imaging. In clinical practice our recommendation is to use Digital Colour Photography. No significant median differences were observed between the pairs no lotion-Essex, no lotion-Aloe vera and Essex-Aloe vera for any of the techniques tested.
authors.affiliation: Department of Chemistry, Umeå University, Umeå, Sweden.
authors.forename: Josefina
authors.initials: J
authors.lastname: Nyström
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Svensk
authors.forename: Britta
authors.initials: B
authors.lastname: Lindholm-Sethson
authors.forename: Paul
authors.initials: P
authors.lastname: Geladi
authors.forename: Johan
authors.initials: J
authors.lastname: Larson
authors.forename: Lars
authors.initials: L
authors.lastname: Franzén
mesh_terms: D000504:Aloe; D001943:Breast Neoplasms / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D004583:Electrons / Q000627:therapeutic use; D004890:Erythema / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005485:Flutamide / Q000008:administration & dosage*; D005782:Gels / Q000008:administration & dosage; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008875:Middle Aged; D010781:Photography / Q000379:methods; D011832:Radiation Injuries / Q000188:drug therapy*; D011882:Radiotherapy, High-Energy; D012867:Skin / Q000098:blood supply / Q000187:drug effects*; D019265:Spectroscopy, Near-Infrared
chemical_list: D005782:Gels; D005485:Flutamide