Influence of carboplatin infusion on osteosarcoma blood flow.
OBJECTIVE
Herein we report that carboplatin infusion influenced tumor blood flow signal independent of the mechanical decompression induced by the artificial lymphatics system technology that was being evaluated as part of a randomized veterinary clinical trial, treating spontaneously occurring canine appendicular osteosarcoma, a tumor very similar to its human counterpart.


METHODS
Blood flow within the central region of the tumor was recorded continuously using laser Doppler flowmetry, a real-time measurement technology. Time-averaged flow values were computed from segments taken from the recordings immediately before starting carboplatin infusion, and during infusion.


RESULTS
Carboplatin increased the tumor blood flow signal by an additional 59 +/- 26% (mean +/- SEM; p = 0.06) over the increase induced by the decompression. The increase started within 49 +/- 46 s after the start of infusion, had a response time constant of 19 +/- 21 s and persisted throughout the infusion, ending shortly after infusion ended.


CONCLUSIONS
The rapidity of the flow signal increase suggests that carboplatin may have an autonomic effect on circulation, either local or systemic. The observations identify a new action of this drug and suggest a possible mechanism to exploit therapeutically.
DiResta
Gene R
GR
Memorial Sloan Kettering Cancer Center, Department of Surgery, Associated with Weill Medical College of Cornell University, Orthopaedic Surgery Service, 1275 York Avenue, New York, NY 10021-6007, USA. direstag@mskcc.org
Aiken
Sean W
SW
Brown
Holly K
HK
Bergman
Philip J
PJ
Hohenhaus
Ann
A
Healey
John H
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000662:veterinary; D016190:Carboplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D016503:Drug Delivery Systems; D004562:Electrocardiography; D007262:Infusions, Intravenous; D017078:Laser-Doppler Flowmetry; D008833:Microcirculation / Q000187:drug effects; D012516:Osteosarcoma / Q000098:blood supply / Q000188:drug therapy / Q000662:veterinary; D013997:Time Factors
D000970:Antineoplastic Agents; D016190:Carboplatin