Traceability of synthetic drugs by position-specific deuterium isotope ratio analysis: the case of Prozac and the fluoxetine generics.
Samples of fluoxetine of different origin were submitted to natural abundance 2H NMR spectroscopy. The deuterium content at the various sites of the molecule was found to depend on its synthetic history. Hints on the synthetic procedure can be obtained by comparison with standard compounds, whose synthesis is known. These preliminary results give an idea of the potential of site-specific isotope ratio analysis in the fight against patent infringement and drug counterfeiting.
Brenna
Elisabetta
E
Dipartimento di Chimica, Materiali e di Ingegneria Chimica del Politecnico di Milano and Istituto CNR per la Chimica del Riconoscimento Molecolare, Via Mancinelli 7, Milano I-20131, Italy. elisabetta.brenna@polimi.it
Fronza
Giovanni
G
Fuganti
Claudio
C
D003903:Deuterium; D016568:Drugs, Generic / Q000032:analysis* / Q000737:chemistry; D005473:Fluoxetine / Q000032:analysis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy
D016568:Drugs, Generic; D005473:Fluoxetine; D003903:Deuterium