title: The umbrella volume: is it useful in applications?
abstract: Invited comment on Alonzo, T. A. and Nakas, C. T. (2007). Comparison of ROC umbrella volumes with an application to the assessment of lung cancer diagnostic markers. Biometrical Journal 49, 654-664. The umbrella volume, proposed as a parameter for diagnostic validity in a specific three group situation might be difficult to interpret in clinical applications. It should be used very cautiously.
authors.affiliation: Institute for Biostatistics and Clinical Epidemiology, Charité University Medicine Berlin, Hindenburgdamm 30, D-12200 Berlin, Germany. peter.martus@charite.de
authors.forename: Peter
authors.initials: P
authors.lastname: Martus
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001699:Biometry / Q000379:methods*; D019175:DNA Methylation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor