Phylogeny of human T cell lymphotropic virus type 1 in Peru: a high degree of evolutionary relatedness with South African isolates.
We investigated the prevalence and molecular epidemiology of human T cell lymphotropic virus type 1 in Peruvian HIV-1-positive subjects, and found a 10.1% prevalence in a consecutive series of 318 HIV-1-positive patients living in Lima. Phylogenetic analysis of the long terminal repeat of 10 patient isolates showed that all of them belonged to the HTLV-1aA (Transcontinental) subgroup. Although the majority of the Peruvian sequences included in the analysis formed a clade with other Latin American sequences, the isolates of three patients clustered significantly with South African strains. These data show a high prevalence of HTLV-1 infection in HIV-1-positive subjects living in Lima and confirm the presence in Latin America of HTLV-1 strains probably arising from South Africa.
Zehender
Gianguglielmo
G
Department of Clinical Sciences L. Sacco, Section of Infectious Diseases, University of Milan, Italy. gianguglielmo.zehender@unimi.it
Ebranati
Erika
E
Bernini
Flavia
F
De Maddalena
Chiara
C
Giambelli
Camilla
C
Collins
Jaime
J
Valverde
Ada
A
Montin
Zeffirino
Z
Galli
Massimo
M
D000328:Adult; D019143:Evolution, Molecular; D005260:Female; D015490:HTLV-I Infections / Q000453:epidemiology* / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010568:Peru / Q000453:epidemiology; D010802:Phylogeny; D015995:Prevalence; D017422:Sequence Analysis, DNA; D013019:South Africa