Gastroprotective activity of the hydroalcoholic extract obtained from Polygala paniculata L. in rats.
The possible gastroprotective effects of the hydroalcoholic extract of Polygala paniculata in rats have been evaluated. We have investigated the effects of this hydroalcoholic extract on acute lesions induced by ethanol (70%, p.o.) and indomethacin (20 mg kg(-1), s.c.). Its influence on mucus secretion was investigated, measured as the amount of Alcian blue dye estimated by colorimetry, and antisecretory effects were assessed in the pylorus ligature model. The treatment of rats with a crude hydroalcoholic extract of P. paniculata (HEPP; 30, 100, 300 mg kg(-1), p.o., or 3, 10 and 30 mg kg(-1), i.p.) decreased the ulcer index, and maintained the gastric mucus production in acute gastric lesions caused by ethanol 70%. In addition, the extract partially protected the mucosa against indomethacin-induced lesions. The extract did not change the volume and acidity of gastric secretion in the pylorus-ligated rat. An additional antioxidant activity of the extract and its isolated flavonoid compound rutin, in the DPPH free radical scavenging assay, was observed. In conclusion, HEPP exhibited marked gastroprotection; these effects may have involved prostaglandins and be related to cytoprotective factors, such as antioxidant activity and maintenance of mucus production.
Lapa
Fernanda da Rocha
Fda R
Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, 88015-420, PR, Brazil.
Freitas
Cristina Setim
CS
Baggio
Cristiane Hatsuko
CH
Missau
Fabiana Cristina
FC
Pizzolatti
Moacir Geraldo
MG
Santos
Adair R S
AR
Marques
Maria Consuelo A
MC
D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D001938:Brazil; D003124:Colorimetry; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005260:Female; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D007213:Indomethacin; D008026:Ligation; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000737:chemistry*; D031801:Polygala / Q000737:chemistry*; D011708:Pylorus; D051381:Rats; D017208:Rats, Wistar; D012431:Rutin / Q000302:isolation & purification / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D010936:Plant Extracts; D000431:Ethanol; D012431:Rutin; D007213:Indomethacin