Histone lysine demethylases: emerging roles in development, physiology and disease.
The discovery of an increasing number of histone demethylases has highlighted the dynamic nature of the regulation of histone methylation, a key chromatin modification that is involved in eukaryotic genome and gene regulation. A flurry of recent studies has offered glimpses into the specific biological roles of these enzymes and their potential connections to human diseases. These advances have also catalysed a resurgence of interest in epigenetic regulators as potential therapeutic targets.
Shi
Yang
Y
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. yshi@hms.harvard.edu
D000595:Amino Acid Sequence; D000818:Animals; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics / Q000502:physiology*; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000235:genetics / Q000378:metabolism*; D008745:Methylation; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology; D009422:Nervous System Diseases / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology
D006657:Histones; D011495:Histone-Lysine N-Methyltransferase; D008239:Lysine