title: A new asymmetric synthesis of the anti-tumor alkaloid (R)-(+)-crispine A.
abstract: We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.
authors.affiliation: Department of Chemistry and Department of Chemical Engineering, Loughborough University, Loughborough, Leicestershire, UK. s.m.allin@lboro.ac.uk
authors.forename: Steven M
authors.initials: SM
authors.lastname: Allin
authors.forename: Sean N
authors.initials: SN
authors.lastname: Gaskell
authors.forename: Joannah M R
authors.initials: JM
authors.lastname: Towler
authors.forename: Philip C Bulman
authors.initials: PC
authors.lastname: Page
authors.forename: Basu
authors.initials: B
authors.lastname: Saha
authors.forename: Michael J
authors.initials: MJ
authors.lastname: McKenzie
authors.forename: William P
authors.initials: WP
authors.lastname: Martin
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D007546:Isoquinolines; C523713:crispine A