title: Effect of topical cyclosporine on tear functions in tear-deficient dry eyes.
abstract: We evaluated the efficacy of topical 2% cyclosporine drops in the treatment of tear-deficient dry eye because of acquired primary lachrymal disease (APLD; 15 patients) and Sjögren syndrome (SS; 15 patients). Symptoms of dryness tended to improve in patients with SS. Schirmer score improved in patients with APLD. Topical CsA 2% drops appears to be safe and effective in the treatment of dry eye patients because in patients with APLD and SS, there is trend toward improvement.
authors.affiliation: Cornea and External Diseases Section, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. aronkjain@yahoo.com
authors.forename: Arun K
authors.initials: AK
authors.lastname: Jain
authors.forename: Jaspreet
authors.initials: J
authors.lastname: Sukhija
authors.forename: Sujata
authors.initials: S
authors.lastname: Dwedi
authors.forename: Archna
authors.initials: A
authors.lastname: Sood
mesh_terms: D000287:Administration, Topical; D000328:Adult; D018592:Cross-Over Studies; D016572:Cyclosporine / Q000008:administration & dosage*; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013666:Tears / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D016572:Cyclosporine