title: Lack of relationship between chronic upper abdominal symptoms and gastric function in functional dyspepsia.
abstract: To determine the relationship between gastric function and upper abdominal sensations we studied sixty FD patients (43 female). All patients underwent three gastric function tests: (13)C octanoic gastric emptying test, three-dimensional ultrasonography (proximal and distal gastric volume), and the nutrient drink test. Upper abdominal sensations experienced in daily life were scored using questionnaires. Impaired proximal gastric relaxation (23%) and a delayed gastric emptying (33%) are highly prevalent in FD patients; however, only a small overlap exists between the two pathophysiologic disorders (5%). No relationship was found between chronic upper abdominal symptoms and gastric function (proximal gastric relaxation, gastric emptying rate, or drinking capacity) (all P > 0.01). Proximal gastric relaxation or gastric emptying rate had no effect on maximum drinking capacity (P > 0.01). The lack of relationship between chronic upper abdominal sensations and gastric function questions the role of these pathophysiologic mechanisms in the generation of symptoms.
authors.affiliation: Department of Gastroenterology, Gastrointestinal Research Unit, University Medical Centre Utrecht, Utrecht, The Netherlands. n.van.lelyveld@meandermc.nl
authors.forename: Niels
authors.initials: N
authors.lastname: van Lelyveld
authors.forename: Maria
authors.initials: M
authors.lastname: Schipper
authors.forename: Melvin
authors.initials: M
authors.lastname: Samsom
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002210:Caprylates; D002250:Carbon Radioisotopes; D016009:Chi-Square Distribution; D004326:Drinking; D004415:Dyspepsia / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D014463:Ultrasonography / Q000379:methods
chemical_list: D002210:Caprylates; D002250:Carbon Radioisotopes