Ser128Arg E-selectin and Thr715Pro P-selectin polymorphisms and severe preeclampsia.
OBJECTIVE
To investigate the association of functional E and P selectin polymorphisms with severe preeclampsia.


METHODS
P-selectin Thr715Pro and E-selectin Serl28Arg polymorphism were determined with the polymerase chain reaction in 126 women with severe preeclampsia and in 106 healthy pregnant women. Genotype distribution and allele prevalence of both groups were compared. Regression analysis was used to analyze the association between disease characteristics and genotype.


RESULTS
Genotype distributions and the allele prevalence were similar in the tested populations. Furthermore, the genotypes investigated had no impact on the risk of eclampsia of the hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. Multiple linear regression analysis identified the P-selectin 715Pro allele as an independent determinant of the time of onset of hypertension (p = 0.034) along with maternal age, smoking and body mass index before pregnancy.


CONCLUSIONS
The polymorphisms tested are not associated with the risk of severe preeclampsia.
Derzbach
László
L
1st Department of Pediatrics, Semmelweis University, Budapest, Hungary. derla@gyer1.sote.hu
Balogh
Adám
A
Bokodi
Géza
G
Vásárhelyi
Barna
B
Rigó
János
J
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D019040:E-Selectin / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D017359:HELLP Syndrome / Q000235:genetics*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D019007:P-Selectin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D015995:Prevalence; D011446:Prospective Studies
D019040:E-Selectin; D019007:P-Selectin