title: Transdermal penetration of UV filters.
abstract: A penetration study of 2-ethylhexyl-4-methoxycinnamate (EHMC), 4-methyl benzylidenecamphor (MBC), butyl methoxydibenzoylmethane (BMBM), 2-ethylhexyl-2,4,5-trimethoxycinnamate (EHTMC) and di(2-ethylhexyl)-2,4,5-trimethoxybenzalmalonate (TMB) through baby mouse skin (Mus musculus Linn.) was carried out using a vertical Franz diffusion cell. At 4.4 mg/cm(2) coverage of UV filter on the skin, 2.98 +/- 0.38, 1.15 +/- 0.14 and 0.80 +/- 0.28% of the applied EHMC, MBC and BMBM were detected in the receptor fluid at 24 h after application. Penetrations of UV filter in an ethanolic solution and lotion forms were comparable. EHTMC and TMB showed insignificant penetration across the baby mouse skins. Baby mouse skins kept at 4, -20 and -80 degrees C gave similar EHMC penetration results. Penetrations of EHMC, BMBM, EHTMC and TMB across human epidermis were carried out upon 5 volunteers using the suction blister technique. The results also confirmed the significant penetrations of EHMC and BMBM and the insignificant penetrations of EHTMC and TMB.
authors.affiliation: Sensor Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Klinubol
authors.forename: P
authors.initials: P
authors.lastname: Asawanonda
authors.forename: S P
authors.initials: SP
authors.lastname: Wanichwecharungruang
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000831:Animals, Newborn; D015194:Diffusion Chambers, Culture / Q000295:instrumentation / Q000379:methods; D004353:Drug Evaluation, Preclinical; D004817:Epidermis / Q000378:metabolism; D005374:Filtration; D006801:Humans; D051379:Mice; D012869:Skin Absorption / Q000502:physiology* / Q000528:radiation effects; D013056:Spectrophotometry, Ultraviolet / Q000295:instrumentation; D013396:Suction; D013473:Sunscreening Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D014466:Ultraviolet Rays
chemical_list: D013473:Sunscreening Agents