PG-liposomes: novel lipid vesicles for skin delivery of drugs.
A novel type of lipid vesicles, propylene glycol-embodying liposomes or PG-liposomes, composed of phospholipid, propylene glycol and water, is introduced. The new lipid vesicles were developed and investigated as carriers for skin delivery of the model drug, cinchocaine base. PG-liposomes showed high entrapment efficiency and were stable for at least one month of storage at 5 +/- 1 degree C. Preliminary in-vivo skin deposition studies, carried out using albino rabbit dorsal skin, showed that PG-liposomes were superior to traditional liposomes, deformable liposomes and ethosomes, suggesting that PG-liposomes, introduced in the current work, are promising carriers for skin delivery of drugs.
Elsayed
Mustafa M A
MM
Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt. mmaelsayed@gmail. com
Abdallah
Ossama Y
OY
Naggar
Viviane F
VF
Khalafallah
Nawal M
NM
D000279:Administration, Cutaneous; D000779:Anesthetics, Local / Q000493:pharmacokinetics*; D000818:Animals; D003992:Dibucaine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D008081:Liposomes; D010713:Phosphatidylcholines / Q000737:chemistry; D019946:Propylene Glycol / Q000737:chemistry*; D011817:Rabbits; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D014867:Water / Q000737:chemistry
D000779:Anesthetics, Local; D004337:Drug Carriers; D008081:Liposomes; D010713:Phosphatidylcholines; D014867:Water; D019946:Propylene Glycol; D003992:Dibucaine