Cerebrospinal fluid cytokine responses in human eosinophilic meningitis associated with angiostrongyliasis.
The levels of interleukin 5 (IL5), IL10, and IL13 in the cerebrospinal fluid (CSF) were markedly higher in 30 patients with eosinophilic meningitis associated with angiostrongyliasis (EOMA) than in the controls (P<0.001). IL2, IL4, interferon gamma (IFNgamma), and tumor necrosis factor alpha (TNFalpha) levels were not significantly different (P>0.05). IL5, IL10, and TNFalpha levels correlated with eosinophil levels (P=0.023, P=0.018, and P=0.005, respectively) while IL2, IL4, IL13, and IFNgamma did not (P>0.05). Our data suggest that local T-helper-2 (TH2) cytokine responses are predominant in the CSF of patients with EOMA. Data on T lymphocyte-parasite interactions are important for the design of effective vaccines and immunotherapies. The measurement of T-helper-1 (TH1)/TH2 cytokines in the CSF may also have some potential for the diagnosis of parasite associated meningitis.
Intapan
Pewpan M
PM
Department of Parasitology, Faculty of Medicine and Research and Diagnostic Center for Emerging Infectious Diseases, Khon Kaen University, Khon Kaen 40002, Thailand. pewpan@kku.ac.th
Kittimongkolma
Suvicha
S
Niwattayakul
Kanigar
K
Sawanyawisuth
Kittisak
K
Maleewong
Wanchai
W
D000293:Adolescent; D000328:Adult; D017185:Angiostrongylus cantonensis / Q000276:immunology; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000134:cerebrospinal fluid; D002648:Child; D016207:Cytokines / Q000134:cerebrospinal fluid* / Q000378:metabolism; D004802:Eosinophilia / Q000134:cerebrospinal fluid / Q000276:immunology / Q000469:parasitology*; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism; D005260:Female; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D016753:Interleukin-10 / Q000134:cerebrospinal fluid / Q000378:metabolism; D018793:Interleukin-13 / Q000134:cerebrospinal fluid / Q000378:metabolism; D015848:Interleukin-5 / Q000134:cerebrospinal fluid / Q000378:metabolism; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000276:immunology* / Q000469:parasitology; D008875:Middle Aged; D017206:Strongylida Infections / Q000134:cerebrospinal fluid* / Q000150:complications / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology
D015415:Biomarkers; D016207:Cytokines; D018793:Interleukin-13; D015848:Interleukin-5; D016753:Interleukin-10