title: Significant changes in circulating plasma levels of IGF1 and IGFBP3 after conventional or dose-intensified adjuvant treatment of breast cancer patients with one to three positive lymph nodes.
abstract: The insulin-like growth factor 1 (IGF1) and its binding protein IGFBP3 (insulin-like growth factor binding protein 3) play a pivotal role during the growth and development of tissues. The purpose of this study was to evaluate the influence of anthracycline- and taxane-containing adjuvant chemotherapy in breast cancer patients on the circulating plasma levels of IGF1 and its main binding protein, IGFBP3. This investigation was part of a prospective randomized phase III study in which breast cancer patients were treated with either conventional or dose-intensified adjuvant chemotherapy. The factors were quantified in the plasma of 151 patients with a commercially available sandwich enzyme immunoassay. Before therapy, both parameters were within the normal range in most patients (n=145 and n=144). After therapy, both factors had increased significantly by 29% (IGF1) and 19% (IGFBP3), with the highest increase being observed in the dose-intensified group. Correlations with patient and tumor characteristics revealed a relatively higher increase in both parameters in premenopausal patients, patients with lower-grade tumors, more positive lymph nodes, larger tumor volume, and positive hormone receptor status. No correlation was found with the HER2 expression of the tumors.
authors.affiliation: Department of Obstetrics and Gynecology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany. sherko.kuemmel@uk-essen.de
authors.forename: S
authors.initials: S
authors.lastname: Kümmel
authors.forename: H
authors.initials: H
authors.lastname: Eggemann
authors.forename: D
authors.initials: D
authors.lastname: Lüftner
authors.forename: N
authors.initials: N
authors.lastname: Gebauer
authors.forename: H
authors.initials: H
authors.lastname: Bühler
authors.forename: G
authors.initials: G
authors.lastname: Schaller
authors.forename: P
authors.initials: P
authors.lastname: Schmid
authors.forename: R
authors.initials: R
authors.lastname: Kreienberg
authors.forename: G
authors.initials: G
authors.lastname: Emons
authors.forename: M
authors.initials: M
authors.lastname: Kriner
authors.forename: D
authors.initials: D
authors.lastname: Elling
authors.forename: J-U
authors.initials: JU
authors.lastname: Blohmer
authors.forename: A
authors.initials: A
authors.lastname: Thomas
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins / Q000096:biosynthesis / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D014408:Biomarkers, Tumor; C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins; D016179:Granulocyte Colony-Stimulating Factor; D015251:Epirubicin; D007334:Insulin-Like Growth Factor I; D003520:Cyclophosphamide; D017239:Paclitaxel