[Effects of cattle encephalon glycoside and ignotin injection on serum level of S100B protein and neuron specific enolase in patients undergoing cardiac valve replacement with cardiopulmonary bypass].
OBJECTIVE
To investigate the effects of cattle encephalon glycoside and ignotin injection on serum level of S100B protein and neuron specific enolase (NSE) during cardiac valve replacement with cardiopulmonary bypass (CPB).


METHODS
Forty patients undergoing cardiac valve replacement with CPB were randomly divided into two equal groups: cattle encephalon glycoside and ignotin injection group (Group A, injected intravenously with cattle encephalon glycoside and ignotin 20 ml after induction of anesthesia, and control group (Group B, injected intravenously with normal saline instead. Blood samples were taken from the jugular bulb after induction of anesthesia (T1), immediately, and 2 h, 6 h, and 24 h after the discontinuation of CPB (T2, T3, T4, and T5) for determination of serum levels of S100B protein and NSE.


RESULTS
The serum levels of S100B protein and NSE of both groups were significantly increased after CPB, and then gradually decreased. At the time point T5, the serum levels of S100B protein of both groups decreased to near the baseline levels (T1 levels), but the serum levels of NSE remained high in both groups. At the time points T2, T3, T4 and T5, the serum levels of S100B protein were significantly higher in Group B than in Group A (all P < 0.05). At the time points T2, T3, and T4, the serum levels of NSE was significantly higher in Group B than in Group A (all P < 0.05).


CONCLUSIONS
Cattle encephalon glycoside and ignotin injection decreases the serum levels of S100B protein and NSE and has cerebral protective effect during cardiac valve replacement with CPB to a certain degree.
Yang
Da-xuan
DX
Department of Anesthesiology, Fuwai Cardiac Hospital, Peking Union Medical College, Beijing 100037, China.
Yang
Jing
J
Li
Li-huan
LH
D000328:Adult; D000818:Animals; D001923:Brain Chemistry; D002315:Cardiopulmonary Bypass; D002417:Cattle; D003131:Combined Modality Therapy; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D012214:Rheumatic Heart Disease / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D014020:Tissue Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D014020:Tissue Extracts; D010751:Phosphopyruvate Hydratase