title: Microalbuminuria and left ventricular function in type 2 diabetes: a quantitative assessment by stress echocardiography in the Myocardial Doppler in Diabetes (MYDID) Study III.
abstract: BACKGROUND
  Left ventricular (LV) function might be altered in type 2 diabetes (DM) and microalbuminuria (MA) may accentuate the abnormalities. We sought to investigate whether additional LV dysfunction could be unmasked using tissue Doppler (TVE)-enhanced dobutamine stress echocardiography (TVE-DSE) in patients with DM + MA.
  
  
  METHODS
  Twenty seven DM subjects with MA, (DM + MA), 31 DM subjects without MA (DM - MA), and 13 Controls were evaluated using TVE-DSE. LV basal peak systolic (PSV), early (E') and late (A') diastolic velocities (cm/sec) at rest and peak stress were post-processed. LV filling pressure was assessed using E/E'ratio.
  
  
  RESULTS
  PSV and E'velocity at peak stress in the respective three groups were 13.7 +/- 1.0, 10.1 +/- 1.1, 10.0 +/- 1.2 for PSV; and 10.0 +/- 1.6, 5.0 +/- 1.4, 4.8 +/- 1.4 for E' (p < 0.001 for controls vs. both groups). E/E' at rest was 7.9 +/- 0.7 in the controls, 10.8 +/- 2.4 in DM - MA, and 11.0 +/- 2.2 in DM + MA (p < 0.01 Controls vs. both the DM groups).
  
  
  CONCLUSIONS
  Patients with DM + MA do not have additional LV regional systolic and diastolic dysfunctions compared with DM -MA, as revealed by TVE-DSE, when controlled for glycemia levels, lipids, and treatment strategies.
authors.affiliation: BMJ Heart Center, Bangalore, India.
authors.forename: Satish C
authors.initials: SC
authors.lastname: Govind
authors.forename: Lars-Ake
authors.initials: LA
authors.lastname: Brodin
authors.forename: Jacek
authors.initials: J
authors.lastname: Nowak
authors.forename: S R
authors.initials: SR
authors.lastname: Arvind
authors.forename: S S
authors.initials: SS
authors.lastname: Ramesh
authors.forename: Anita
authors.initials: A
authors.lastname: Netyö
authors.forename: K Y M
authors.initials: KY
authors.lastname: Prasad
authors.forename: Samir
authors.initials: S
authors.lastname: Saha
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000453:epidemiology* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000503:physiopathology; D025401:Echocardiography, Stress / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000503:physiopathology