title: Clinical outcome of long-term home parenteral nutrition in non-oncological patients: a report from two specialised centres.
abstract: OBJECTIVE
  Forty-one (20 m, 21 f) non-oncological home parenteral nutrition (HPN) patients (52.0+/-16.6 years, BMI 20.2+/-4.0 kg/m(2)), enrolled from 1995 to 2005, underwent a clinical and biochemical follow-up at 3 months, 1 and 3 years.
  
  
  RESULTS
  At admittance the Karnofsky Index ranged between 40 and 50 in 13 (31.7%) and 60 and 80 in 28 (68.3%) patients; the most frequent underlying disease was mesenteric infarction (11 patients, 27%). All had a central venous access. Mean catheterization days were 864+/-992, while mean HPN days were 630+/-668. At the 3-month follow-up, all patients were on HPN, at 1 year 24 (58.5%) and at 3 years 11 (27%). At 3 months, 1 and 3 years there was a significant increase in BMI (p=0.001), body weight (p=0.001) and Karnofsky Index (p=0.001), as well as an improvement of several biochemical parameters. Survival rate of HPN patients was 90.2% at 1 year, 87.8% at 3 years and 82.9% at 5 years. As to HPN-related complications, there was a central venous catheter (CVC) obstruction in 8 patients (19.5%) and 47 CVC infections in 24 (58.5%) patients. The infection rate was 1.32/(00) days of catheterization (1.8/(00) from 1995 to 1998 and 1.0/(00) from 1999 to 2005). Hospitalisation was necessary in over 50% of patients, and death occurred in 8, always as a consequence of the primary disease.
  
  
  CONCLUSIONS
  The experience of the nutritional team and careful patient and caregiver training reduce CVC infection rate and the overall risk of complications possibly due to HPN.
authors.affiliation: Internal Medicine and Clinical Nutrition, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Bonifacio
authors.forename: L
authors.initials: L
authors.lastname: Alfonsi
authors.forename: L
authors.initials: L
authors.lastname: Santarpia
authors.forename: A
authors.initials: A
authors.lastname: Orban
authors.forename: A
authors.initials: A
authors.lastname: Celona
authors.forename: G
authors.initials: G
authors.lastname: Negro
authors.forename: F
authors.initials: F
authors.lastname: Pasanisi
authors.forename: F
authors.initials: F
authors.lastname: Contaldo
mesh_terms: D001835:Body Weight; D005260:Female; D006305:Health Status Indicators; D006306:Health Surveys; D006699:Home Care Services; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000178:diet therapy / Q000401:mortality*; D009752:Nutritional Status; D016331:Parenteral Nutrition, Home; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome