Solution-phase parallel synthesis of diverse 1,5-benzodiazepin-2-ones.
A practical and efficient parallel method has been developed for the synthesis of 1,5-benzodiazepin-2-ones with a large variety of substituents at the 3-, 4-, 5-, 7-, and 8-positions using 1,5-difluoro-2,4-dinitrobenzene as the starting material. All the reactions involved here are highly effective in giving the desired products under mild conditions.
Zhao
Hai-Yan
HY
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 2 Nanwei Rd, Xuanwu Dist., Beijing 100050, PR China.
Liu
Gang
G
D001570:Benzodiazepinones / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D004139:Dinitrofluorobenzene / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical
D001570:Benzodiazepinones; D004139:Dinitrofluorobenzene