title: Role of chelates in treatment of cancer.
abstract: Chelates are used in cancer as cytotoxic agent, as radioactive agent in imaging studies and in radioimmunotherapy. Various chelates based on ruthenium, copper, zinc organocobalt, gold, platinum, palladium, cobalt, nickel and iron are reported as cytotoxic agent. Monoclonal antibodies labeled with radioactive metals such as yttrium-90, indium-111 and iodine-131 are used in radioimmunotherapy. This review is an attempt to compile the use of chelates as cytotoxic drugs and in radioimmunotherapy.
authors.affiliation: Department of Pharmaceutical Chemistry, SD College of Pharmacy and Vocational Studies, Muzaffarnagar, Uttar Pradesh, India. tripathilaxmi@rediffmail.com
authors.forename: Laxmi
authors.initials: L
authors.lastname: Tripathi
authors.forename: Praveen
authors.initials: P
authors.lastname: Kumar
authors.forename: A K
authors.initials: AK
authors.lastname: Singhai
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D048708:Cell Growth Processes / Q000187:drug effects / Q000528:radiation effects; D002614:Chelating Agents / Q000627:therapeutic use; D015913:Chelation Therapy / Q000639:trends*; D003603:Cytotoxins / Q000627:therapeutic use; D004358:Drug Therapy / Q000639:trends*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D016499:Radioimmunotherapy / Q000639:trends*; D011868:Radioisotopes / Q000627:therapeutic use; D051381:Rats; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D002614:Chelating Agents; D003603:Cytotoxins; D011868:Radioisotopes