title: Origins of blood volume change due to glutamatergic synaptic activity at astrocytes abutting on arteriolar smooth muscle cells.
abstract: The cellular mechanisms that couple activity of glutamatergic synapses with changes in blood flow, measured by a variety of techniques including the BOLD signal, have not previously been modelled. Here we provide such a model, that successfully accounts for the main observed changes in blood flow in both visual cortex and somatosensory cortex following their stimulation by high-contrast drifting grating or by single whisker stimulation, respectively. Coupling from glutamatergic synapses to smooth muscle cells of arterioles is effected by astrocytes releasing epoxyeicosatrienoic acids (EETs) onto them, following glutamate stimulation of the astrocyte. Coupling of EETs to the smooth muscle of arterioles is by means of potassium channels in their membranes, leading to hyperpolarization, relaxation and hence an increase in blood flow. This model predicts a linear increase in blood flow with increasing numbers of activated astrocytes, but a non-linear increase with increasing glutamate release.
authors.affiliation: The Neurobiology Laboratory, Department of Physiology, University of Sydney, NSW 2006, Australia. maxb@physiol.usyd.edu.au <maxb@physiol.usyd.edu.au>
authors.forename: M R
authors.initials: MR
authors.lastname: Bennett
authors.forename: L
authors.initials: L
authors.lastname: Farnell
authors.forename: W G
authors.initials: WG
authors.lastname: Gibson
mesh_terms: D001160:Arterioles / Q000294:innervation / Q000502:physiology; D001253:Astrocytes / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology*; D002196:Capillaries / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D008959:Models, Neurological; D009131:Muscle, Smooth, Vascular / Q000294:innervation / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D013003:Somatosensory Cortex / Q000098:blood supply; D013569:Synapses / Q000502:physiology*; D014793:Visual Cortex / Q000098:blood supply
chemical_list: D018698:Glutamic Acid