Radical hysterectomy for stage IB1 cervical carcinoma: lymph node metastasis as a prognostic factor.
OBJECTIVE
Lymph node metastasis is one of the most important factors influencing prognosis and further therapy in patients with cervical carcinoma. The aim of this study was to confirm the impact of nodal metastasis od disease-free interval in women with stage IB1 cancer of the uterine cervix.


METHODS
From June 1986 to December 1999 269 patients with stage IB1 cervical carcinoma were operated on. Two hundred thirty-six (87.84%) patients had class III and 33 (12.16%) class II radical hysterectomy, according to Piver's classification.


RESULTS
The median number of the removed lymph nodes was 21. Positive lymph nodes were found in 71 (25.28%) patients. All patients with positive lymph nodes received postoperative adjuvant external beam radiotherapy. Patients with bulky nodal disease received also chemotherapy.Overall 5-year disease-free interval in 212 patients was 80%. Five-year disease-free interval for patients without lymph node metastasis was 91%, while it was 40% in those with lymph node metastasis (p < 0.0001).


CONCLUSIONS
Surgical staging of cervical cancer, which includes pelvic and para-aortic lymphadenectomy,together with pathological data, can provide potentially useful information for the radiation oncologist and precise analysis of survival and prognostic risk factors.
Novaković
P
P
Institute of Oncology Sremska Kamenica, Department of Gynecologic Oncology, Sremska Kamenica, Yugoslavia. aljosa.m@eunet.yu
Mandić
A
A
Vujkov
T
T
Tesi
M
M
Rajović
J
J
Zivaljević
M
M
Popović
M
M