Electronegative electroretinogram associated with topiramate toxicity and vitelliform maculopathy.
Topiramate is known to cause ocular side effects such as refractive changes and angle closure. We describe a patient with an electronegative electroretinogram (ERG) which may have been related to topiramate use. Electronegative ERG's have been associated with other drugs in humans as well as topiramate use in rabbits. However, this would be the first suggestion of causality in humans.
Tsui
Irena
I
Brown Glaucoma Laboratory at Edward S. Harkness Eye Institute, Columbia University, New York, NY 10032, USA. irena.tsui@gmail.com
Casper
Daniel
D
Chou
Chai Lin
CL
Tsang
Stephen H
SH
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004596:Electroretinography / Q000187:drug effects*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008268:Macular Degeneration / Q000139:chemically induced* / Q000175:diagnosis; D020190:Myoclonic Epilepsy, Juvenile / Q000188:drug therapy; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose