Penetration of topically applied tacrolimus into the aqueous humor in Behçet's disease.
We investigated the concentration of tacrolimus in aqueous humor, and serum of patients with ocular Behçet's disease after topical application in 11 patients. All received 1 drop of isotonic tacrolimus solution 0.3% every 6 hours for 3 days. The mean tacrolimus concentration in the aqueous and serum, as measured by microparticle enzyme immunoassay, were 12.49 and 0.76 ng/mL, respectively. Tacrolimus may be a promising treatment modality in anterior uveitis in Behçet's disease by topical application.
Yalçindağ
F Nilüfer
FN
Ophthalmology Department, Ankara University Faculty of Medicine, Esat Caddes i 74/3 Küçükesat, Ankara, 06660, Turkey. yalcinda@medicine.ankara.edu.tr
Batioğlu
Figen
F
Ozdemir
Ozden
O
D000042:Absorption / Q000187:drug effects / Q000502:physiology; D000287:Administration, Topical; D000328:Adult; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism*; D001528:Behcet Syndrome / Q000188:drug therapy* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D016559:Tacrolimus / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D016559:Tacrolimus