title: Thrombin generation determined by calibrated automated thrombography (CAT) in pediatric patients with congenital heart disease.
abstract: BACKGROUND
  Thrombin generation was studied in pediatric patients with congenital heart disease (CHD) undergoing cardiac surgery using the calibrated automated thrombography (CAT) in terms of the lag time until the onset of thrombin formation, time to thrombin peak maximum (TTP), endogenous thrombin potential (ETP), and thrombin peak height. The possible suitability to determine the coagulation status of these patients was investigated.
  
  
  METHODS
  CAT data of 40 patients with CHD (age range from newborn to 18 years) were compared to data using standard coagulation parameters such as prothrombin (FII), antithrombin (AT), tissue factor pathway inhibitor (TFPI), prothrombin fragment 1.2 (F 1.2), thrombin-antithrombin (TAT), activated partial thromboplastin time (aPTT), and prothrombin time (PT).
  
  
  RESULTS
  A significant positive correlation was seen between ETP and FII (p<0.01; r=0.369), as well as between peak height and F II (p<0.01; r=0.483). A significant negative correlation was seen between ETP and TFPI values (p<0.05; r=-0.225) while no significant correlation was seen between peak height and TFPI. A significant negative correlation was seen between F 1.2 generation and ETP (p<0.05; r=-0.254) and between F 1.2 generation and peak height (p<0.05; r=-0.236). No correlation was seen between AT and ETP or peak.
  
  
  CONCLUSIONS
  Our data indicate that CAT is a good global test reflecting procoagulatory and inhibitory factors of the hemostatic system in pediatric patients with CHD.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Auenbruggerplatz 30, A-8036 Graz, Austria. koestenbergerm@gmx.at
authors.forename: Martin
authors.initials: M
authors.lastname: Koestenberger
authors.forename: Gerhard
authors.initials: G
authors.lastname: Cvirn
authors.forename: Bert
authors.initials: B
authors.lastname: Nagel
authors.forename: Andrea
authors.initials: A
authors.lastname: Rosenkranz
authors.forename: Bettina
authors.initials: B
authors.lastname: Leschnik
authors.forename: Andreas
authors.initials: A
authors.lastname: Gamillscheg
authors.forename: Albrecht
authors.initials: A
authors.lastname: Beitzke
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Muntean
mesh_terms: D000293:Adolescent; D000991:Antithrombins / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D006330:Heart Defects, Congenital / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007700:Kinetics; D010314:Partial Thromboplastin Time; D010446:Peptide Fragments / Q000097:blood; D011517:Prothrombin Time; D013917:Thrombin / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D000991:Antithrombins; D010446:Peptide Fragments; D013917:Thrombin