title: Carcinoma cuniculatum of the larynx: a rare clinicopathological entity.
abstract: OBJECTIVE
  Carcinoma cuniculatum is a rare variant of low-grade squamous cell carcinoma. We report the second case of carcinoma cuniculatum of the larynx in the literature.
  
  
  METHODS
  Case report and review of the world literature concerning carcinoma cuniculatum of the larynx and upper aerodigestive tract.
  
  
  RESULTS
  A histologically proven carcinoma cuniculatum of the larynx is reported in a 72-year-old man. The patient underwent a supracricoid laryngectomy with crico-hyoidopexy, and was free of disease at 70 months after surgery. We emphasise the clinical presentation, histology and therapeutic approach of this rare tumour.
  
  
  CONCLUSIONS
  To our knowledge this is the second report in the world literature of carcinoma cuniculatum of the larynx. Carcinoma cuniculatum of the larynx must be considered as a distinct 'clinicopathological entity' and close cooperation between the clinician and the pathologist is essential for the correct diagnosis of these tumour as regards to the correct classification and therapy.
authors.affiliation: Department of Otorhinolaryngology, Queen Alexandra Hospital, Portsmouth, UK. roberto.puxeddu@porthosp.nhs.uk
authors.forename: R
authors.initials: R
authors.lastname: Puxeddu
authors.forename: D
authors.initials: D
authors.lastname: Cocco
authors.forename: G
authors.initials: G
authors.lastname: Parodo
authors.forename: G
authors.initials: G
authors.lastname: Mallarini
authors.forename: M
authors.initials: M
authors.lastname: Medda
authors.forename: P A
authors.initials: PA
authors.lastname: Brennan
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods; D008297:Male; D016896:Treatment Outcome