title: Convenient access to 1,3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation.
abstract: Novel 1-aryl-3-(5-nitro-2-thienyl)-4-aroyl-pyrazoles 7 have been synthesized by the 1,3-dipolar cycloaddition of 3-arylsydnones 3 with 1-aryl-3-(5-nitro-2-thienyl)-2-propyn-1-ones 6. The newly synthesized compounds were well characterized by elemental analysis, IR, (1)H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies have been discussed in this article.
authors.affiliation: Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri-574 199, Karnataka, India.
authors.forename: N Satheesha
authors.initials: NS
authors.lastname: Rai
authors.forename: Balakrishna
authors.initials: B
authors.lastname: Kalluraya
authors.forename: B
authors.initials: B
authors.lastname: Lingappa
authors.forename: Shaliny
authors.initials: S
authors.lastname: Shenoy
authors.forename: Vedavati G
authors.initials: VG
authors.lastname: Puranic
mesh_terms: D000114:Acetylene / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D017672:Nitrogen Compounds / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013558:Sydnones / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D007659:Ketones; D017672:Nitrogen Compounds; D011720:Pyrazoles; D013558:Sydnones; D013876:Thiophenes; D000114:Acetylene