title: Efficacy of an intranasal modified live bovine respiratory syncytial virus and temperature-sensitive parainfluenza type 3 virus vaccine in 3-week-old calves experimentally challenged with PI3V.
abstract: Two experimental parainfluenza type 3 virus (PI3V) challenge studies were undertaken to evaluate the efficacy of a single intranasal dose of an attenuated live vaccine containing modified live bovine respiratory syncytial virus (BRSV) and temperature-sensitive PI3V in 3-week-old calves. In the first study, vaccine efficacy was evaluated in colostrum deprived calves. Nasal shedding of PI3V was highly significantly reduced in vaccinated calves challenged 10 days or 21 days after vaccination. In the second study, vaccine efficacy was assessed in calves with maternal antibodies against PI3V by challenge 66 days post-vaccination. Vaccination also significantly reduced PI3V excretion after challenge in this study. In both studies, clinical signs after challenge were very mild and were not different between vaccinated and control calves.
authors.affiliation: Pfizer Animal Health, Veterinary Medicine Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. ilse.vangeel@pfizer.com
authors.forename: Ilse
authors.initials: I
authors.lastname: Vangeel
authors.forename: Faye
authors.initials: F
authors.lastname: Ioannou
authors.forename: Lutz
authors.initials: L
authors.lastname: Riegler
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Salt
authors.forename: Silke S
authors.initials: SS
authors.lastname: Harmeyer
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000831:Animals, Newborn; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D029101:Parainfluenza Virus 3, Bovine / Q000276:immunology*; D011897:Random Allocation; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D018112:Respiratory Syncytial Virus, Bovine / Q000276:immunology*; D010253:Respirovirus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D016896:Treatment Outcome; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D017201:Virus Shedding
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines