title: Infective endocarditis in a hemodialysis patient: a dreaded complication.
abstract: Infection is the most common cause of death in hemodialysis patients, after cardiovascular disease. Dialysis access infections, with secondary septicemia, contribute significantly to patient mortality. The most common source is temporary catheterization. Bacteremia occurs commonly in patients receiving hemodialysis, with infective endocarditis being a relatively uncommon, but potentially lethal complication. Valvular calcification is the most significant risk factor. The diagnosis of infective endocarditis is made clinically and confirmed with the echocardiographic modified Duke's criteria. The most common pathogen is Staphylococcus aureus and the mitral valve is the most common site. Staphylococcus aureus infective endocarditis is commonly associated with embolic phenomenon. A high index of suspicion is critical in the early recognition and management of infective endocarditis. However, prevention of bacteremia is undoubtedly the best strategy with the early placement of arteriovenous fistulae. In the case of temporary catheterization, the use of topical mupirocin or polysporin and gentamicin and/or citrate locking is beneficial. Although catheter salvage has not been studied in randomized trials, catheter removal remains standard therapy during bacteremia.
authors.affiliation: Department of Medicine, Faculty of Health Sciences, University of Stellenbosch, Cape Town, South Africa.
authors.forename: Claudia
authors.initials: C
authors.lastname: Schubert
authors.forename: Mohammed R
authors.initials: MR
authors.lastname: Moosa
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology; D001022:Aortic Valve Insufficiency / Q000209:etiology; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000379:methods; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000150:complications; D007396:Internship and Residency; D007674:Kidney Diseases / Q000628:therapy; D008297:Male; D012008:Recurrence; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents