MUC1 in human testis and ejaculated spermatozoa and its relationship to male fertility status.
MUC1 is a cell surface glycoprotein with a previously described antiadhesive role involved in different aspects of reproductive function. We found MUC1 expressed in male germ cell line and within the ejaculated sperm, but its presence in mature sperm does not seem to be related to male fertility. This was confirmed after analysis of results from assisted reproduction techniques with oocyte donation related with MUC1, although higher MUC1 expression is related to sperm recovery after preparation.
Martínez-Conejero
José A
JA
Fundación Instituto Valenciano de Infertilidad, Valencia, Spain. jomarco@ivi.es
Garrido
Nicolás
N
Remohí
José
J
Pellicer
Antonio
A
Simón
Carlos
C
Meseguer
Marcos
M
D053713:Azoospermia / Q000503:physiopathology; D004542:Ejaculation; D005298:Fertility / Q000502:physiology*; D006801:Humans; D008297:Male; D018396:Mucin-1 / Q000032:analysis* / Q000502:physiology; D013094:Spermatozoa / Q000737:chemistry*; D013737:Testis / Q000737:chemistry*
C060192:MUC1 protein, human; D018396:Mucin-1