title: [Genetic basis of ankylosing spondylitis].
abstract: Ankylosing spondylitis (AS) is a common rheumatic condition, highly heritable. Much of the genetic contribution to the disease lies in the major histocompatibility complex (MHC). The association with the allele group HLA-B*27 has been described worldwide for 30 years. On the other hand, genome wide scans have provided some interesting results showing that other MHC and non-MHC genes could be implicated either in disease susceptibility and phenotypic manifestations. Different hypothesis for disease pathophysiology have been investigated which contribute for a better understanding of the genetic basis of AS. This review aims to summarize the status of the knowledge in this exciting area. New data may, in a near future, change the screening of patients and generate new insights for the emergence of novel therapies.
authors.affiliation: Serviço de Reumatologia do CHLO EPE, Hospital de Egas Moniz, Lisbon. pimentel.santos@gmail.com
authors.forename: F Pimentel dos
authors.initials: FP
authors.lastname: Santos
authors.forename: E
authors.initials: E
authors.lastname: Bastos
authors.forename: D
authors.initials: D
authors.lastname: Ligeiro
authors.forename: A F
authors.initials: AF
authors.lastname: Mourão
authors.forename: R
authors.initials: R
authors.lastname: Chaves
authors.forename: H
authors.initials: H
authors.lastname: Trindade
authors.forename: H
authors.initials: H
authors.lastname: Guedes-Pinto
authors.forename: J C
authors.initials: JC
authors.lastname: Branco
mesh_terms: D015235:HLA-B Antigens / Q000235:genetics; D015796:HLA-B27 Antigen / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000235:genetics*
chemical_list: D015235:HLA-B Antigens; D015796:HLA-B27 Antigen