The trigeminal vasculature pathology in patients with neuralgia.
OBJECTIVE
To examine the possible pathological changes of the trigeminal vasculature in patients with neuralgia.


BACKGROUND
Such a study has never been performed before. The alterations of the trigeminal vessels could have important pathophysiological implications in the trigeminal neuralgia pathogenesis.


METHODS
The biopsy specimens for the electronmicroscopic (EM) and immunohistochemical examination were taken during a partial rhizotomy in 6 patients with trigeminal neuralgia and in 2 persons with trigeminal neuropathy. In addition, the 32 normal trigeminal nerves were used as the control specimens.


RESULTS
The vascular pathological alterations were noticed in 3 out of 6 neuralgia patients. The EM study revealed signs of apoptosis or degeneration, respectively, of some endothelial and smooth muscle cells in the wall of the trigeminal arterioles. The immune reactions against CD31, CD34, and alpha-smooth muscle actin in these cells were weaker than in the control specimens, but stronger against factor VIII. In addition, the arteriolar basement membranes, which were thickened, showed an intense laminin, fibronectin, and collagen IV immunoreactivity. Similarly, some endothelial cells and pericytes of the intratrigeminal capillaries also showed signs of apoptosis or degeneration, respectively. Their basement membrane was very thick and showed an intense immune reaction against laminin, fibronectin, and collagen IV.


CONCLUSIONS
The observed pathological changes of the trigeminal vasculature could be the primary factor, while demyelination of the trigeminal nerve fibers could be the secondary process in some patients with neuralgia.
Marinković
Slobodan
S
Institute of Anatomy, School of Medicine, University of Belgrade, Belgrade, Serbia.
Todorović
Vera
V
Gibo
Hirohiko
H
Budec
Mirela
M
Drndarević
Neda
N
Pesić
Dragoslava
D
Joković
Milos
M
Cetković
Mila
M
D000328:Adult; D000368:Aged; D001160:Arterioles / Q000473:pathology; D002196:Capillaries / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D019051:Rhizotomy; D014276:Trigeminal Nerve / Q000098:blood supply* / Q000473:pathology; D014277:Trigeminal Neuralgia / Q000473:pathology* / Q000601:surgery