[Women with poor response to ovarian stimulation have increased follicular bone morphogenetic protein-15 levels].
To evaluate the levels of bone morphogenetic protein-15 (BMP-15) in human follicular fluid (FF) and its association with response to ovarian stimulation.



Western blotting was performed to determine the levels of BMP-15 in FF obtained from follicle aspirates in 70 patients undergoing IVF treatment. According to the response to ovarian stimulation the patients were divided into poor responder group and normal responder group.



BMP-15 levels in FF of poor responders were significantly higher than those in normal responders (1.01 +/- 0.34 vs 0.77 +/- 0.24, P<0.01).



Increased levels of BMP-15 in FF may be associated with poor response to ovarian stimulation.
Wu
Yan-ting
YT
The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.
Lu
Xiu-e
XE
Wang
Ting-ting
TT
He
Rong-huan
RH
Xu
Jian
J
Huang
He-feng
HF
D000328:Adult; D015153:Blotting, Western; D055430:Bone Morphogenetic Protein 15; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D015571:Follicular Fluid / Q000187:drug effects / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives; D055429:Growth Differentiation Factor 9; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D010062:Ovulation Induction
C525901:BMP15 protein, human; D055430:Bone Morphogenetic Protein 15; C525897:GDF9 protein, human; D055429:Growth Differentiation Factor 9; D036341:Intercellular Signaling Peptides and Proteins; D007987:Gonadotropin-Releasing Hormone; C083781:LHRH, Ala(6)-Gly(10)-ethylamide-; D005640:Follicle Stimulating Hormone