Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells.
Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens are reduced. Here, we demonstrate that malaria infection or the parasite pigment hemozoin inhibits T cell and DC interactions both in vitro and in vivo, while signal 1 intensity remains unaltered. This altered cellular behaviour is associated with the suppression of DC costimulatory activity and functional T cell responses, potentially explaining why immunity is reduced during malaria infection.
Millington
Owain R
OR
Centre for Biophotonics, University of Strathclyde, Glasgow, United Kingdom.
Gibson
Vivienne B
VB
Rush
Catherine M
CM
Zinselmeyer
Bernd H
BH
Phillips
R Stephen
RS
Garside
Paul
P
Brewer
James M
JM
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000276:immunology; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D006420:Hemeproteins / Q000378:metabolism / Q000494:pharmacology; D006790:Host-Parasite Interactions; D008213:Lymphocyte Activation / Q000276:immunology; D008288:Malaria / Q000097:blood / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010587:Phagocytosis; D010860:Pigments, Biological / Q000378:metabolism / Q000494:pharmacology; D016788:Plasmodium chabaudi / Q000276:immunology*; D021382:Protein Sorting Signals / Q000187:drug effects / Q000502:physiology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism
D006420:Hemeproteins; D010860:Pigments, Biological; D021382:Protein Sorting Signals; C020753:hemozoin