title: Anti-Ro52 antibodies, antisynthetase antibodies, and antisynthetase syndrome.
abstract: We present a case of antisynthetase syndrome manifesting with interstitial lung disease, mechanic's hands, nailfold abnormalities, and subclinical myositis, in the presence of antibodies to the aminoacyl tRNA synthetase PL-12 and also to Ro52. Antibodies to Ro52 have been recently associated with idiopathic inflammatory myositis, but there have only been occasional reports of this antibody occurring in association with aminoacyl tRNA synthetases, including PL-12. Our case adds to the descriptions of the concurrence of antibodies to PL-12 and Ro52. The mechanism for the coupling of antibody response remains elusive but is likely to play a fundamental role in disease pathogenesis.
authors.affiliation: Rheumatology Department, Royal Adelaide Hospital, North Tce, Adelaide, Australia. vlimaye@optusnet.com.au
authors.forename: Vidya S
authors.initials: VS
authors.lastname: Limaye
authors.forename: John
authors.initials: J
authors.lastname: Cassidy
authors.forename: Grace
authors.initials: G
authors.lastname: Scott
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Roberts-Thomson
authors.forename: David
authors.initials: D
authors.lastname: Gillis
mesh_terms: D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000175:diagnosis* / Q000276:immunology; D008025:Ligases / Q000276:immunology*; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000276:immunology; D009220:Myositis / Q000175:diagnosis* / Q000276:immunology; D012261:Ribonucleoproteins / Q000276:immunology*; D013577:Syndrome; D000099207:SS-A Antigen
chemical_list: D000888:Antibodies, Anti-Idiotypic; D008025:Ligases; D012261:Ribonucleoproteins; D000099207:SS-A Antigen