title: Effect of an excessive intake of quercetin on the vitamin E level and antioxidative enzyme activities of mouse liver under paraquat-induced oxidative stress.
abstract: The liver alpha-tocopherol level of the paraquat fed mice group was lower than that of the control diet-fed group. An excessive intake of quercetin lowered the liver alpha-tocopherol level of the control diet-fed mice group, but did not affect it in the paraquat-fed mice group. The same quercetin intake significantly increased the superoxide dismutase and glutathione peroxidase activities in the liver of both groups, indicating that excessive quercetin intake can either promote or attenuate oxidative stress in the liver.
authors.affiliation: Department of Food Science, Graduate School of Nutrition and Bioscience, The University of Tokushima, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Bando
authors.forename: Saori
authors.initials: S
authors.lastname: Wakamatsu
authors.forename: Junji
authors.initials: J
authors.lastname: Terao
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D005260:Female; D005979:Glutathione Peroxidase / Q000032:analysis / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress / Q000187:drug effects*; D010269:Paraquat / Q000008:administration & dosage / Q000633:toxicity*; D011794:Quercetin / Q000008:administration & dosage*; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism; D013997:Time Factors; D014810:Vitamin E / Q000032:analysis / Q000378:metabolism*; D024502:alpha-Tocopherol / Q000032:analysis / Q000378:metabolism
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D011794:Quercetin; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D024502:alpha-Tocopherol; D010269:Paraquat