title: Synthesis and anti-mycobacterial activity of (E)-N'-(monosubstituted-benzylidene)isonicotinohydrazide derivatives.
abstract: A series of 22 (E)-N'-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in mug/mL. Compounds 2f, 2g, 2j, 2k and 2q exhibited a significant activity (0.31-0.62 microg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.
authors.affiliation: Fundação Oswaldo Cruz, Instituto de Pesquisas Clínicas Evandro Chagas, Departamento de Bacteriologia, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, Brazil.
authors.forename: Maria Cristina da Silva
authors.initials: MC
authors.lastname: Lourenço
authors.forename: Marcelle de Lima
authors.initials: Mde L
authors.lastname: Ferreira
authors.forename: Marcus Vinícius Nora
authors.initials: MV
authors.lastname: de Souza
authors.forename: Mônica Amado
authors.initials: MA
authors.lastname: Peralta
authors.forename: Thatyana Rocha Alves
authors.initials: TR
authors.lastname: Vasconcelos
authors.forename: Maria das Graças M O
authors.initials: Md
authors.lastname: Henriques
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013055:Spectrophotometry, Infrared
chemical_list: D000995:Antitubercular Agents; D006834:Hydrazines