title: Ibuprofen-induced HUS.
abstract: BACKGROUND
  Hemolytic uremic syndrome (HUS) is a disease characterized by nonimmune hemolytic anemia, thrombocytopenia and renal impairment. There are many causes for HUS, but adverse reactions to drugs have been increasingly reported. Even the NSAIDs which have been reported as safe and effective painkillers are described as cause of recurrent HUS.
  
  
  METHODS
  We describe a case of a 44-year-old woman who was admitted to our hospital because of thrombocytopenia and anemia after the use of 8 tablets of 400 mg ibuprofen (NSAIDs). The diagnosis HUS was made and she recovered completely after treatment with fresh-frozen plasma and seven plasma exchanges.
  
  
  CONCLUSIONS
  No cause could be identified except the use of ibuprofen. Recognition of a drug-induced HUS is necessary to avoid reexposure and recurrent HUS.
authors.affiliation: Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands. niks50@hotmail.com
authors.forename: N J
authors.initials: NJ
authors.lastname: Schoenmaker
authors.forename: J J
authors.initials: JJ
authors.lastname: Weening
authors.forename: R T
authors.initials: RT
authors.lastname: Krediet
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen