Cytotoxic lignans from the stem bark of Magnolia officinalis.
Three new lignans, 4'-methoxymagndialdehyde ( 1), 4'-methoxymagnaldehyde B ( 2), and 4'-methoxymagnaldehyde E ( 3), were isolated from hexane- and EtOAc-soluble fractions of the stem bark of Magnolia officinalis, together with eight known compounds ( 4- 11). The structures of compounds 1- 3 were determined on the basis of spectroscopic and physicochemical data analysis. Compounds 1- 11 were tested in vitro for their cytotoxic activity against the K562, HeLa, and A549 cancer cell lines. Among the compounds tested, compound 1 showed the most potent cytotoxic activity against these cancer cell lines, with IC50 values of 3.9, 1.5, and 3.7 microg/mL, respectively.
Youn
Ui-Joung
UJ
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Chen
Quan Cheng
QC
Jin
Wen-Yi
WY
Lee
Ik-Soo
IS
Kim
Hong-Jin
HJ
Lee
Jong-Pill
JP
Chang
Min-Jung
MJ
Min
Byung-Sun
BS
Bae
Ki-Hwan
KH
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007723:Korea; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031566:Magnolia / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
C524952:4'-methoxymagnaldehyde B; C524953:4'-methoxymagnaldehyde E; C524951:4'-methoxymagndialdehyde; D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans