title: Dual mechanisms of DNA damage by MoCH(3)(eta(3)-allyl)(CO)(2)(phen) complexes.
abstract: DNA damage by MoCH3(eta3-allyl)(CO)2(phen) complexes has been shown to occur by two mechanisms: by backbone cleavage via the abstraction of H1' and/or H5' from the deoxyribose moiety and by base modification, resulting in G-specific cleavage via the formation of base-labile residues methylguanine, methoxyguanine, and 8-oxo-G.
authors.affiliation: Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA. mohlerdl@jmu.edu
authors.forename: Debra L
authors.initials: DL
authors.lastname: Mohler
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Shell
authors.forename: Janet G
authors.initials: JG
authors.lastname: Coonce
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Mirandi
authors.forename: Lucía
authors.initials: L
authors.lastname: Riera
authors.forename: Luciano
authors.initials: L
authors.lastname: Cuesta
authors.forename: Julio
authors.initials: J
authors.lastname: Pérez
mesh_terms: D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D008982:Molybdenum; D004247:DNA