Ibuprofen-induced HUS.
BACKGROUND
Hemolytic uremic syndrome (HUS) is a disease characterized by nonimmune hemolytic anemia, thrombocytopenia and renal impairment. There are many causes for HUS, but adverse reactions to drugs have been increasingly reported. Even the NSAIDs which have been reported as safe and effective painkillers are described as cause of recurrent HUS.


METHODS
We describe a case of a 44-year-old woman who was admitted to our hospital because of thrombocytopenia and anemia after the use of 8 tablets of 400 mg ibuprofen (NSAIDs). The diagnosis HUS was made and she recovered completely after treatment with fresh-frozen plasma and seven plasma exchanges.


CONCLUSIONS
No cause could be identified except the use of ibuprofen. Recognition of a drug-induced HUS is necessary to avoid reexposure and recurrent HUS.
Schoenmaker
N J
NJ
Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands. niks50@hotmail.com
Weening
J J
JJ
Krediet
R T
RT
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen