Does FASing out new fat in the hypothalamus make you slim?
Fatty acid synthase (FAS) is a key enzyme for lipogenesis. A recent study (Chakravarthy et al., 2007) shows that the targeted deletion of FAS in hypothalamic neurons produces hypophagic, lean mice and suggests that PPARalpha signaling is an important mediator of the effects of FAS on energy homeostasis.
Buettner
Christoph
C
Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. christoph.buettner@mssm.edu
D000818:Animals; D064429:Fatty Acid Synthases / Q000235:genetics*; D007031:Hypothalamus / Q000166:cytology / Q000201:enzymology*; D051379:Mice; D009474:Neurons / Q000201:enzymology; D009765:Obesity / Q000235:genetics*; D047493:PPAR alpha; D015431:Weight Loss / Q000235:genetics*
D047493:PPAR alpha; D064429:Fatty Acid Synthases