title: Synthesis, characterization and cytotoxicity of diam(m)-ineplatinum(II) complexes containing beta-phenylisosuccinate ligand.
abstract: Four diam(m)ineplatinum(II) complexes containing beta-phenylisosuccinate as the leaving groups were prepared, characterized, and evaluated for their cytotoxicity against A549/ATCC human lung cancer cell line and SGC-7901 human gastric cancer cell line. One of the complexes, (trans-1R,2R-diaminocyclohexane)-beta-phenylisosuccinatoplatinum(II) 4, was much more active than cisplatin and carboplatin.
authors.affiliation: Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming, Yunnan, China.
authors.forename: Qing-Song
authors.initials: QS
authors.lastname: Ye
authors.forename: Li-Guang
authors.initials: LG
authors.lastname: Lou
authors.forename: Zuo-Yan
authors.initials: ZY
authors.lastname: Liu
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Liu
authors.forename: Shu-Qian
authors.initials: SQ
authors.lastname: Hou
authors.forename: Xi-Zhu
authors.initials: XZ
authors.lastname: Chen
authors.forename: Yao
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000031:analogs & derivatives*; D015195:Drug Design; D006801:Humans; D007536:Isomerism; D008024:Ligands; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D013386:Succinates / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009944:Organoplatinum Compounds; D013386:Succinates; C017625:2-phenylsuccinate; D002945:Cisplatin