title: Polysaccharides from the green seaweeds Codium fragile and C. vermilara with controversial effects on hemostasis.
abstract: Codium fragile and Codium vermilara biosynthesize water-soluble sulfated arabinans and galactans (and/or sulfated arabinogalactans), alpha(1-->4)-D-glucans and beta(1-->4)-D-mannans. The former polysaccharides are composed by 3-linked beta-D-galactopyranose and beta-L-arabinopyranose residues, they are highly sulfated and substituted with pyruvic acid ketals. For both seaweeds, they have the same main structural units, but in different percentages. All the room-temperature water extracts from both seaweeds showed a dual haemostatic effect: they prevented coagulation, but they induced platelet aggregation. Anticoagulant activity and platelet aggregation were higher in the samples with polysaccharides richer in sulfate, mainly in those from C. vermilara, which have a higher degree of sulfation and arabinose content.
authors.affiliation: Cátedra de Química Orgánica, Departamento de Biología Aplicada y Alimentos (CIHIDECAR-CONICET), Facultad de Agronomía, Universidad de Buenos Aires, Avenue San Martín 4453, C1417DSE Buenos Aires, Argentina. ciancia@agro.uba.ar
authors.forename: Marina
authors.initials: M
authors.lastname: Ciancia
authors.forename: Irene
authors.initials: I
authors.lastname: Quintana
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Vizcargüénaga
authors.forename: Luciana
authors.initials: L
authors.lastname: Kasulin
authors.forename: Agustina
authors.initials: A
authors.lastname: de Dios
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Estevez
authors.forename: Alberto Saúl
authors.initials: AS
authors.lastname: Cerezo
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology*; D001089:Arabinose; D005690:Galactose; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010974:Platelet Aggregation / Q000187:drug effects*; D011134:Polysaccharides / Q000302:isolation & purification* / Q000494:pharmacology*; D011402:Pronase; D012624:Seaweed / Q000737:chemistry*
chemical_list: D000925:Anticoagulants; D011134:Polysaccharides; D001089:Arabinose; D011402:Pronase; D005690:Galactose