title: Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
abstract: Transferable quinolone resistance has not previously been reported in Argentina. Here we describe three complex class 1 integrons harboring the novel allele qnrB10 in a unique region downstream of orf513, one of them also containing aac(6')-Ib-cr within the variable region of integrons. The three arrays differed from bla(CTX-M-2)-bearing integrons, which are broadly distributed in Argentina.
authors.affiliation: Departamento de Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, P-12, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: María Paula
authors.initials: MP
authors.lastname: Quiroga
authors.forename: Patricia
authors.initials: P
authors.lastname: Andres
authors.forename: Alejandro
authors.initials: A
authors.lastname: Petroni
authors.forename: Alfonso J C
authors.initials: AJ
authors.lastname: Soler Bistué
authors.forename: Leonor
authors.initials: L
authors.lastname: Guerriero
authors.forename: Liliana Jordá
authors.initials: LJ
authors.lastname: Vargas
authors.forename: Angeles
authors.initials: A
authors.lastname: Zorreguieta
authors.forename: Marta
authors.initials: M
authors.lastname: Tokumoto
authors.forename: Cecilia
authors.initials: C
authors.lastname: Quiroga
authors.forename: Marcelo E
authors.initials: ME
authors.lastname: Tolmasky
authors.forename: Marcelo
authors.initials: M
authors.lastname: Galas
authors.forename: Daniela
authors.initials: D
authors.lastname: Centrón
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D001118:Argentina; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D003428:Cross Infection / Q000382:microbiology; D004251:DNA Transposable Elements / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D006801:Humans; D032023:Integrons / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D001618:beta-Lactamases