Biology of the subventricular zone in relation to gliomagenesis.
There is recent compelling evidence that gliomas arise from neural stem cells residing in the lining of the lateral ventricles, known as the subventricular zone, that have undergone malignant transformation. This article reviews the operative elements, including cytoskeletal proteins, tumor suppressor genes, cell adhesion molecules, growth factors, transcription factors and developmental pathways that link the subventricular zone to gliomagenesis. It is hoped that with an improved understanding of the putative source of gliomas, new therapeutic strategies will be developed against such deadly tumors.
Barami
Kaveh
K
Memorial Neuroscience Center, Memorial Hospital Jacksonville, Jacksonville, Florida, USA. kbarami@yahoo.com
D001932:Brain Neoplasms / Q000473:pathology*; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins / Q000378:metabolism; D016147:Genes, Tumor Suppressor / Q000502:physiology; D005910:Glioma / Q000473:pathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D020547:Lateral Ventricles / Q000033:anatomy & histology / Q000473:pathology*; D013234:Stem Cells / Q000502:physiology; D019098:Telomerase / Q000378:metabolism; D014157:Transcription Factors / Q000502:physiology
D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D036341:Intercellular Signaling Peptides and Proteins; D014157:Transcription Factors; D019098:Telomerase