Can probability of genetic mutation be an indicator of clinical relevance?
NPM1 gene mutation evaluated on a population basis is a valuable and realistic tool to reflect the pathophysiological relevance of cancer. In a comparison of the NPM1 cDNA of human bladder cancer with its consensus sequence, we have found that a higher NPM1 sequence identity in a population is consistent with poor tumor differentiation, advanced tumor stage, and likelihood of recurrence. These data imply that "probability" of NPM1 mutation is an indicator of status of malignancy.
Chen
Chien-Lun
CL
Department of Urology, Chang Gung Memorial Hospital, Chang Gung Bioinformatics Center, Kwei-Shan, Tao-Yuan 333, Taiwan, ROC.
Tsui
Ke-Hung
KH
Lin
Chiao-Yun
CY
Chang
Phei-Lang
PL
Tang
Petrus
P
Yung
Benjamin  Yat-Ming
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000473:pathology; D017931:DNA Primers / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000235:genetics*; D000090243:Nucleophosmin; D011336:Probability; D012008:Recurrence; D012689:Sequence Homology, Nucleic Acid; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
D017931:DNA Primers; D018076:DNA, Complementary; D004273:DNA, Neoplasm; C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D000090243:Nucleophosmin