title: Markers of cardiac collagen turnover are similar in patients with mild and more severe symptoms of heart failure.
abstract: Cardiac fibrosis plays an important role in the pathophysiology of heart failure. The authors sought to determine whether biomarkers of cardiac fibrosis for milder clinical degrees of heart failure are comparable to those of more advanced disease. Procollagen types I and III amino-terminal peptides (PINP and PIIINP) and type I collagen telopeptide (ICTP) were compared between aldosterone-antagonistnaive patients with heart failure and New York Heart Association class I or II (n=22/23) and class III or IV (n=42/3) symptoms. Median (interquartile) range concentrations of PINP (63.3 [44.2-88.8] vs 48.6 [37.8-74.9] microg/L), ICTP (7.0 [5.4-16.8] vs 6.5 [4.7-12.7] microg/L), and PIIINP (4.7 [3.2-7.0] vs 4.7 [2.9-7.3] microg/L) were comparable between patients with mild and moderate to severe disease, respectively. These data suggest that patients with mild heart failure may have similar degrees of cardiac fibrosis to patients with more severe disease and support the examination of antifibrotic therapy, including aldosterone antagonists, in milder degrees of heart failure.
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy University of Illinois at Chicago, Chicago, IL 60612-7230, USA. humma@uic.edu
authors.forename: Larisa H
authors.initials: LH
authors.lastname: Cavallari
authors.forename: Vicki L
authors.initials: VL
authors.lastname: Groo
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Momary
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Stamos
authors.forename: Paul T
authors.initials: PT
authors.lastname: Vaitkus
mesh_terms: D000328:Adult; D015415:Biomarkers; D003094:Collagen; D018450:Disease Progression; D005260:Female; D005355:Fibrosis / Q000503:physiopathology*; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D011446:Prospective Studies; D012720:Severity of Illness Index; D018434:Sickness Impact Profile
chemical_list: D015415:Biomarkers; D003094:Collagen