title: A prospective study of familial versus sporadic Parkinson's disease.
abstract: BACKGROUND
  Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Most cases are sporadic but about 10-15% of patients have a positive family history of PD.
  
  
  OBJECTIVE
  To compare clinical phenotypes between familial (fPD) and sporadic (sPD) PD patients.
  
  
  METHODS
  Fifty-nine consecutive patients with at least one first-degree relative with PD were prospectively studied. After exclusion of 9 PD patients with positive family carrying known disease causing mutations, the remaining 50 were compared with 50 age- and sex-matched sPD patients.
  
  
  RESULTS
  Despite our methodological approach (strict diagnostic criteria, validated scales, structured interviews, multi- and two-member group formation and exclusion of patients with identifiable mutations) no major differences in the clinical phenotype between fPD and sPD were found.
  
  
  CONCLUSIONS
  Similar phenotypic characteristics of motor signs and symptoms suggest that at least the topography of the neurodegenerative insult leading to the parkinsonian clinical syndrome in fPD and sPD is similar. Similar etiologies are also suggested.
authors.affiliation: Department of Neurology, Regional University Hospital of Patras, Patras, Greece. spapapetropoulos@med.miami.edu
authors.forename: Spiridon
authors.initials: S
authors.lastname: Papapetropoulos
authors.forename: Nikhil
authors.initials: N
authors.lastname: Adi
authors.forename: John
authors.initials: J
authors.lastname: Ellul
authors.forename: Andreas A
authors.initials: AA
authors.lastname: Argyriou
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Chroni
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000145:classification / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*; D010641:Phenotype; D011446:Prospective Studies; D012720:Severity of Illness Index