title: Pituitary adenoma with tumoral granulomatous reaction.
abstract: Herein, we report a unique case of an adult male with a corticotrophic pituitary adenoma of silent subtype 1 exhibiting conspicuous idiopathic tumoral noncaseating granulomatous inflammation. The lesion was unassociated with clinical or laboratory evidence of either systemic sarcoidosis or infection. Histochemical and polymerase chain reaction (PCR) studies revealed neither fungi nor tubercle bacilli. We suggest that tumoral production of an as yet uncharacterized antigen may have induced the granulomatous inflammatory reaction.
authors.affiliation: Department of Pathology and Laboratory Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. scheithauer.bernd@mayo.edu
authors.forename: Bernd W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Silva
authors.forename: John L D
authors.initials: JL
authors.lastname: Atkinson
authors.forename: Todd B
authors.initials: TB
authors.lastname: Nippoldt
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Kaufmann
authors.forename: Kalman
authors.initials: K
authors.lastname: Kovacs
authors.forename: Eva
authors.initials: E
authors.lastname: Horvath
authors.forename: Ricardo
authors.initials: R
authors.lastname: Lloyd
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000473:pathology* / Q000601:surgery; D000236:Adenoma / Q000473:pathology* / Q000601:surgery; D001794:Blood Pressure; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010907:Pituitary Hormones / Q000097:blood; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000601:surgery; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014786:Vision Disorders / Q000209:etiology
chemical_list: D010907:Pituitary Hormones; D013739:Testosterone; D013972:Thyrotropin; D013974:Thyroxine