Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet's disease by up-front cord blood transplantation.
Behçet's disease is a chronic, relapsing, inflammatory disease of unknown origin. The association of myelodysplastic syndrome and Behçet's disease is rare, and recent reports have indicated that immunosuppressive agents alone are not sufficient to control Behçet's disease associated with MDS and many patients die of infection or hemorrhage. We report a case of MDS with intestinal Behçet's disease. We performed cord blood transplantation with a myeloablative regimen as the primary treatment. The patient achieved complete remission for both diseases, which continued for more than 16 months. Our experience suggests that CBT may provide a potent therapeutic option for the treatment of MDS-related Behçet's disease.
Nonami
Atsushi
A
First Department of Internal Medicine, Graduate School of Medicine, Kyushu University, Fukuoka. anonamin@yahoo.co.jp
Takenaka
Katsuto
K
Sumida
Chinatsu
C
Aizawa
Kumiko
K
Kamezaki
Kenjiro
K
Miyamoto
Toshihiro
T
Harada
Naoki
N
Nagafuji
Koji
K
Teshima
Takanori
T
Harada
Mine
M
D000328:Adult; D001528:Behcet Syndrome / Q000150:complications*; D002898:Chromosomes, Human, Pair 8; D036101:Cord Blood Stem Cell Transplantation; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications*; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics / Q000628:therapy*; D019172:Transplantation Conditioning; D014314:Trisomy