title: [Toxicity of BPA and TBBPA to Daphnia magna and zebrafish Brachydanio rerio].
abstract: Acute toxicity of BPA and TBBPA to Daphnia magna, zebrafish (Brachydanio rerio) and development effects of zebrafish embryo and zebrafish. The tested chemicals remarkably restrained the were studied, and safety assessment was also made to Daphnia magna mobilization of Daphnia magna, which may cause them death. 48 h EC50 values for D. magna were 8.91 and 0.69 mg x L(-1) respectively. In addition, the chemicals showed the toxicity effects on zebrafish, and 96 h LC50 values were 9.06 and 1.78 mg x L(-1) respectively. BPA and TBBPA remarkably retarded the development of zebrafish embryos, which may cause embryo abnormality and death. And the most sensitive toxicological endpoints to BPA and TBBPA were found, 72 h EC50 (malformation and embryo do not hatch) values were 2.90 and 0.14 mg x L(-1) respectively. The results showed that zebrafish embryo should be the most sensitive to the tested chemicals. The results indicated that BPA and TBBPA were the pollutants with high toxicity, in which TBBPA had the higher toxicity. BPA is a potential teratogen to zebrafish embryos, while TBBPA restrains embryo from hatch.
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China. njliuhl@yahoo.com.cn
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Liu
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Liu
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Wang
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Wang
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Yu
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D003621:Daphnia / Q000187:drug effects* / Q000254:growth & development; D007928:Lethal Dose 50; D010636:Phenols / Q000633:toxicity*; D011075:Polybrominated Biphenyls / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015027:Zebrafish / Q000254:growth & development*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; D011075:Polybrominated Biphenyls; D014874:Water Pollutants, Chemical; C020806:tetrabromobisphenol A; C006780:bisphenol A; D000098826:Bisphenol A Compounds