CD8+ T cells in inflammatory demyelinating disease.
We review the contribution made by CD8+ T cells to inflammation in the central nervous system (CNS) in Multiple Sclerosis (MS), and discuss their role in the animal model Experimental Autoimmune Encephalomyelitis (EAE). We show that the inflammatory cytokines interferon-gamma and interleukin-17 are differentially regulated in CNS-infiltrating CD4+ and CD8+ T cells in EAE, and that CD8+ T cells regulate disease. In MS, CD8+ T cells appear to play a role in promotion of disease, so cytokine regulation is likely different in CD8+ T cells in MS and EAE.
Weiss
Hanne A
HA
Medical Biotechnology Center, University of Southern Denmark, Winsloewparken 25, DK-5000 Odense C, Denmark.
Millward
Jason M
JM
Owens
Trevor
T
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000502:physiology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000502:physiology; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology
D016207:Cytokines; D020381:Interleukin-17