Bacterial eradication rates with shortened courses of 2nd- and 3rd-generation cephalosporins versus 10 days of penicillin for treatment of group A streptococcal tonsillopharyngitis in adults.
In a meta-analysis of 5 randomized controlled trials involving 1030 adults, the likelihood of bacteriologic eradication in the treatment of group A beta-hemolytic streptococcal (GAS) tonsillopharyngitis with 5 days of select cephalosporins (cefpodoxime, cefuroxime, cefotiam, and cefdinir) was noninferior to 10 days of penicillin (odds ratio, 1.46; 95% confidence interval, 0.96-2.22, P = 0.08).
Pichichero
Michael E
ME
University of Rochester, and Elmwood Pediatric Group, Rochester, NY 14642, USA. michael_pichichero@urmc.rochester.edu
Casey
Janet R
JR
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000145:classification / Q000627:therapeutic use; D002511:Cephalosporins / Q000008:administration & dosage* / Q000145:classification / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use; D010612:Pharyngitis / Q000188:drug therapy* / Q000382:microbiology; D016032:Randomized Controlled Trials as Topic; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000187:drug effects*; D014069:Tonsillitis / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins