Spiroiminodihydantoin as an oxo-atom transfer product of 8-oxo-2'-deoxyguanosine oxidation by chromium(V).
Oxidation of the DNA lesion 8-oxo-2'-deoxyguanosine by the two electron oxidants N,N'-ethylenebis(salicylideneanimato)oxochromium(V) (Cr(V)-salen) and bis(2-ethyl-2-hydroxybutyrato)oxochromium(V) (Cr(V)-ehba) at neutral pH forms spiroiminodihydantoin by an oxo-atom transfer mechanism. The chromium complexes are models of a DNA oxidation pathway caused by the carcinogen chromate.
Slade
Peter G
PG
Department of Chemistry, The University of Montana, 32 Campus Drive, Missoula, Montana 59812, USA.
Priestley
Nigel D
ND
Sugden
Kent D
KD
D000080242:8-Hydroxy-2'-Deoxyguanosine; D002857:Chromium / Q000737:chemistry*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry; D006151:Guanosine / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013141:Spiro Compounds / Q000737:chemistry*
D013141:Spiro Compounds; C408822:spiroiminodihydantoin; D002857:Chromium; D006151:Guanosine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine