Fatal winter dysentery with severe anemia in an adult cow.
An adult dairy cow fatally affected with winter dysentery was investigated pathologically and virologically. The cow had severe anemia and diarrhea with massive blood. Pathologically, the loss of surface epithelial cells and necrosis of crypt epithelial cells in the large intestine were observed. Bovine coronavirus (BCV) antigen was observed in necrotic crypt epithelial cells of the large intestine. Virus particles were found in the necrotic epithelial cells of the large intestine. Virologically, BCV was isolated from the feces of the dead cow. The dead cow had no serum antibody against BCV although the co-habitants did. These suggest that severe infection of BCV in the cow without the BCV antibody accompanied by severe hemorrhagic anemia resulted in the cow's death.
Natsuaki
Sumiko
S
Fukuoka Kitakyushu Livestock Hygiene Services Center, 3-20-13 Nakayoshida, Kokuraminami, Kitakyushu 800-0204, Japan.
Goto
Keiichi
K
Nakamura
Kikuyasu
K
Yamada
Manabu
M
Ueo
Hiroshi
H
Komori
Toshihiro
T
Shirakawa
Hitomi
H
Uchinuno
Yukinori
Y
D000740:Anemia / Q000097:blood / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000473:pathology / Q000821:virology*; D018352:Coronavirus Infections / Q000662:veterinary* / Q000821:virology; D017938:Coronavirus, Bovine / Q000254:growth & development*; D004403:Dysentery / Q000097:blood / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D017809:Fatal Outcome; D005243:Feces / Q000821:virology; D005260:Female
D000914:Antibodies, Viral