A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.
Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC (50) values ranged from 0.13 +/- 0.02 to 6.09 +/- 0.07 microM.
Lee
Tzong-Huei
TH
Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan, ROC.
Lee
Ching-Kuo
CK
Tsou
Wan-Lin
WL
Liu
Sheng-Yung
SY
Kuo
Mao-Tien
MT
Wen
Wu-Che
WC
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D025282:Mycelium; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020072:Polyporales; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014451:Ubiquinone; C545357:antroquinonol