title: Early detection of right ventricular systolic dysfunction by using myocardial acceleration during isovolumic contraction in patients with mitral stenosis.
abstract: OBJECTIVE
  The aim of the study was to determine if the tissue Doppler imaging (TDI)-derived myocardial acceleration during isovolumic contraction (IVA) of tricuspid lateral annulus could be used in early detection of RV systolic dysfunction in patients with mitral stenosis (MS), before the clinical signs of systemic venous congestion occur.
  
  
  METHODS
  One hundred and twelve patients with rheumatic MS without relevant regurgitation and 60 control subjects were enrolled in the study. Conventional echocardiographic parameters (mitral valve area, transmitral diastolic gradients, pulmonary artery pressure, RV fractional shortening, pulmonary flow acceleration time, tricuspid annular plane systolic excursion) and TDI-derived systolic velocities of tricuspid annulus (isovolumic myocardial acceleration: IVA, peak myocardial velocity during isovolumic contraction: IVV, peak systolic velocity during ejection period: Sa and RV Tei index) were recorded from all patients.
  
  
  RESULTS
  TDI-derived IVA, IVV, Sa and Tei index were found to be significantly decreased in patients with MS. IVA was the only parameter which had a significant negative correlation with the traditional echocardiographic parameters and RV Tei index in patients with MS. Additionally, in subgroup analyses, IVA was significantly lower in patients with severe degree of MS.
  
  
  CONCLUSIONS
  TDI-derived right ventricular IVA may be used as an adjunctive, reliable, noninvasive parameter for the early detection of right ventricular systolic dysfunction in patients with MS but without signs of systemic venous congestion.
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Capa, Istanbul, Turkey. yeldatayyareci@hotmail.com
authors.forename: Yelda
authors.initials: Y
authors.lastname: Tayyareci
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Nisanci
authors.forename: Berrin
authors.initials: B
authors.lastname: Umman
authors.forename: Aytac
authors.initials: A
authors.lastname: Oncul
authors.forename: Selen
authors.initials: S
authors.lastname: Yurdakul
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Altun
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Umman
authors.forename: Zehra
authors.initials: Z
authors.lastname: Bugra
mesh_terms: D000328:Adult; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging*; D009200:Myocardial Contraction; D013599:Systole; D014261:Tricuspid Valve / Q000000981:diagnostic imaging; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000209:etiology