title: Resistin: a hormone which induces insulin resistance is increased in normal pregnancy.
abstract: OBJECTIVE
  Resistin, a newly discovered adipokine, is thought to play a key role in the regulation of insulin resistance. The objectives of this study were to develop a nomogram of maternal plasma concentrations of resistin from 11 weeks of gestation to term and to determine whether resistin concentrations differ between normal and overweight pregnant women.
  
  
  METHODS
  In this cross-sectional study, plasma concentrations of resistin were determined in normal pregnant women of normal body mass index (BMI 18.5-24.9; n=261), overweight pregnant women (BMI > or =25; n=140), and non-pregnant women of normal BMI (n=40). Blood samples were collected once from each woman between the first trimester and term. Percentiles for resistin concentration were determined for five pre-specified windows of gestational age. Plasma resistin concentration was determined by immunoassay. Non-parametric statistics were used for analysis.
  
  
  RESULTS
  The median maternal plasma concentration of resistin between 11 to 14 weeks of gestation in women of normal weight was significantly higher than non-pregnant women; the plasma concentration of resistin increased with gestational age.
  
  
  CONCLUSIONS
  Normal pregnant women have a higher median plasma concentration of resistin than non-pregnant women and the concentration of this adipokine increases with advancing gestation. Alterations in the maternal plasma concentration of resistin during pregnancy could contribute to metabolic changes of pregnancy.
authors.affiliation: Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, USA.
authors.forename: Jyh Kae
authors.initials: JK
authors.lastname: Nien
authors.forename: Shali
authors.initials: S
authors.lastname: Mazaki-Tovi
authors.forename: Roberto
authors.initials: R
authors.lastname: Romero
authors.forename: Juan Pedro
authors.initials: JP
authors.lastname: Kusanovic
authors.forename: Offer
authors.initials: O
authors.lastname: Erez
authors.forename: Francesca
authors.initials: F
authors.lastname: Gotsch
authors.forename: Beth L
authors.initials: BL
authors.lastname: Pineles
authors.forename: Lara A
authors.initials: LA
authors.lastname: Friel
authors.forename: Jimmy
authors.initials: J
authors.lastname: Espinoza
authors.forename: Luis
authors.initials: L
authors.lastname: Goncalves
authors.forename: Joaquin
authors.initials: J
authors.lastname: Santolaya
authors.forename: Ricardo
authors.initials: R
authors.lastname: Gomez
authors.forename: Joon-Seok
authors.initials: JS
authors.lastname: Hong
authors.forename: Samuel
authors.initials: S
authors.lastname: Edwin
authors.forename: Eleazar
authors.initials: E
authors.lastname: Soto
authors.forename: Karina
authors.initials: K
authors.lastname: Richani
authors.forename: Moshe
authors.initials: M
authors.lastname: Mazor
authors.forename: Sonia S
authors.initials: SS
authors.lastname: Hassan
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D049451:Nomograms; D011247:Pregnancy / Q000097:blood / Q000502:physiology*; D052243:Resistin / Q000097:blood* / Q000378:metabolism
chemical_list: D052243:Resistin