title: Factors affecting anastomotic complications following anterior resection in rectal cancer.
abstract: OBJECTIVE
  Anastomotic complications following sphincter saving rectal surgery remains a significant clinical problem in rectal cancer surgery. Preoperative combined modality therapy followed by anterior resection with total mesorectal excision (TME) has become the preferred treatment paradigm for locally advanced rectal cancer. However, its impact on anastomotic complications has not been adequately evaluated. This study aimed to assess the relationship between the response of the primary tumour to neo-adjuvant therapy with anastomotic complications and to evaluate the effect of other clinico-pathological factors previously implicated, in this patient cohort.
  
  
  METHODS
  A total of 119 consecutive patients with primary rectal cancer were assessed of which there were 87 anterior resections. A prospectively collected database was queried to determine the incidence of anastomotic complications, association with response to neo-adjuvant therapy and other clinico-pathological factors. Data were analysed with SPSS 14.0.
  
  
  RESULTS
  Anterior resection was performed in 87/111 (78.4%) patients of which 46/84 (56%) were low resections, with an abdominoperineal excision of rectum rate of 11/111 (9.9%). Anastomotic complications were seen as clinical leaks in 10/87 (11.5%) and late colo-visceral fistulae in 2/87 (2.2%) patients. Subclinical/ radiological 'leaks' were quantified as 4/87 (4.5%). A good pathological response to neo-adjuvant therapy was found to be strongly associated with anastomotic complications (P = 0.006). Presence of a perioperative cardiac event was the only other clinical factor associated with anastomotic complications (P = 0.004) in our study.
  
  
  CONCLUSIONS
  Rectal cancer treated with neo-adjuvant therapy and radical resection with TME for better local control may be associated with greater anastomotic complications particularly when a good pathological response is seen.
authors.affiliation: Department of Surgery, Aberdeen Royal Infirmary, Aberdeen, UK. ashima_lyall@yahoo.co.uk
authors.forename: A
authors.initials: A
authors.lastname: Lyall
authors.forename: T K
authors.initials: TK
authors.lastname: Mc Adam
authors.forename: J
authors.initials: J
authors.lastname: Townend
authors.forename: M A
authors.initials: MA
authors.lastname: Loudon
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant; D005242:Fecal Incontinence / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007412:Intestinal Fistula; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011183:Postoperative Complications / Q000453:epidemiology*; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery*; D012007:Rectum / Q000601:surgery