Cytokine signaling to the cell cycle.
The proliferation of many myeloid and lymphoid cell populations is directly controlled by cytokine growth factors acting through a related family of cytokine receptors. This regulation implies that the signaling pathways activated by cytokine receptors must communicate with mechanisms that control mammalian cell cycle progression. Evidence for how these signaling pathways promote hematopoietic cell proliferation is considered along with their likely targets among the cell cycle regulators.
Quelle
Frederick W
FW
Department of Pharmacology and The Graduate Program in Immunology, The University of Iowa, Carver College of Medicine, 2-210 Bowen Science Bld, Iowa City, IA 52242, USA. frederick-quelle@uiowa.edu
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D018121:Receptors, Cytokine / Q000378:metabolism*; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction
D016207:Cytokines; D047908:Intracellular Signaling Peptides and Proteins; D018121:Receptors, Cytokine; D050791:STAT Transcription Factors; D019869:Phosphatidylinositol 3-Kinases; D020928:Mitogen-Activated Protein Kinases