title: Highly diastereoselective and enantioselective direct organocatalytic anti-selective Mannich reactions employing N-tosylimines.
abstract: Organocatalytic direct anti-selective Mannich reactions of O-TBS-hydroxyacetone with various N-tosylimines derived from aromatic aldehydes in the presence of L-threonine-derived catalyst afforded 1,2-amino alcohols in good yields and with enantioselectivities of 99% in almost all cases.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive, Singapore 117543, Republic of Singapore.
authors.forename: Lili
authors.initials: L
authors.lastname: Cheng
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.forename: Huiming
authors.initials: H
authors.lastname: Huang
authors.forename: Ming Wah
authors.initials: MW
authors.lastname: Wong
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry; D008352:Mannich Bases; D015394:Molecular Structure; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry; D014105:Tosyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D007097:Imines; D008352:Mannich Bases; D013449:Sulfonamides; D014105:Tosyl Compounds