[Justifying the use of primary tissue culture method for evaluation of sodium fluoride safety in nutrition products].
Toxicity of sodium fluoride added to nutrition products is assessed through peculiarities of kidney tissue culture growth in vitro--over 75% inhibition of cell clumps growth supports high toxic influence of sodium fluoride, the growth decrease from 63% to 74% signifies lower degree, the growth inhibition less than 62% demonstrates very low toxicity of the chemical.
Gromova
L E
LE
Pashchenko
V P
VP
Nazarenko
N A
NA
Degteva
G N
GN
D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005458:Fluoride Poisoning / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005502:Food / Q000592:standards*; D005504:Food Analysis / Q000379:methods*; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D018977:Micronutrients / Q000633:toxicity*; D012969:Sodium Fluoride / Q000633:toxicity*; D018675:Toxicity Tests / Q000379:methods*
D018977:Micronutrients; D012969:Sodium Fluoride