Type 2 diabetes mellitus: phylogenetic motifs for predicting protein functional sites.
Diabetes mellitus, commonly referred to as diabetes, is a medical condition associated with abnormally high levels of glucose (or sugar) in the blood. Keeping this view, we demonstrate the phylogenetic motifs (PMs) identification in type 2 diabetes mellitus very likely corresponding to protein functional sites. In this article, we have identified PMs for all the candidate genes for type 2 diabetes mellitus. Glycine 310 remains conserved for glucokinase and potassium channel KCNJ11. Isoleucine 137 was conserved for insulin receptor and regulatory subunit of a phosphorylating enzyme. Whereas residues valine, leucine, methionine were highly conserved for insulin receptor. Occurrence of proline was very high for calpain 10 gene and glucose transporter.
Sharma
Ashok
A
Bioinformatics Division, Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 226 015, India. ashoksharma@cimap.res.in
Rastogi
Tanuja
T
Bhartiya
Meenakshi
M
Shasany
A K
AK
Khanuja
S P S
SP
D020816:Amino Acid Motifs / Q000235:genetics* / Q000502:physiology; D001665:Binding Sites / Q000235:genetics; D020134:Catalytic Domain / Q000235:genetics; D017124:Conserved Sequence; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D010802:Phylogeny; D011237:Predictive Value of Tests; D011506:Proteins / Q000235:genetics* / Q000502:physiology; D020539:Sequence Analysis, Protein; D017386:Sequence Homology, Amino Acid
D011506:Proteins