title: Potent inhibition of genital herpesvirus infection in goats by cidofovir.
abstract: BACKGROUND
  Like human herpesvirus 2 (HHV-2) in humans, infection by caprine herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects of anti-herpetic drugs.
  
  
  METHODS
  The antiviral activity of cidofovir was assessed in goats infected experimentally, using various therapeutic protocols.
  
  
  RESULTS
  Topic administration of cidofovir 1% cream prevented the onset of virus-induced genital lesions and drastically reduced virus shedding.
  
  
  CONCLUSIONS
  Cidofovir appears to be a very efficient drug for the prevention of genital lesions caused by an alphaherpesvirus.
authors.affiliation: Department of Animal Health and Well-being, Faculty of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy. m.tempesta@veterinaria.uniba.it
authors.forename: Maria
authors.initials: M
authors.lastname: Tempesta
authors.forename: Michele
authors.initials: M
authors.lastname: Camero
authors.forename: Anna Lucia
authors.initials: AL
authors.lastname: Bellacicco
authors.forename: Elvira
authors.initials: E
authors.lastname: Tarsitano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Crescenzo
authors.forename: Julien
authors.initials: J
authors.lastname: Thiry
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Nicola
authors.initials: N
authors.lastname: Decaro
authors.forename: Gabriella
authors.initials: G
authors.lastname: Elia
authors.forename: Johan
authors.initials: J
authors.lastname: Neyts
authors.forename: Etienne
authors.initials: E
authors.lastname: Thiry
authors.forename: Canio
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006041:Goats; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000821:virology; D006566:Herpesviridae Infections / Q000188:drug therapy* / Q000821:virology; D063065:Organophosphonates / Q000627:therapeutic use*; D018140:Varicellovirus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir