Oxidative stress and asymmetric dimethylarginine is independently associated with carotid intima media thickness in peritoneal dialysis patients.
BACKGROUND
Oxidative stress (OS) and asymmetric dimethylarginine (ADMA) are accepted as nonclassical cardiovascular risk factors in end-stage renal disease patients. To clarify the role of these factors in the atherosclerotic process, we investigated if OS and ADMA are associated with common carotid artery intima media thickness (CIMT) in peritoneal dialysis (PD) patients.


METHODS
Thirty PD patients without known atherosclerotic disease and classical cardiovascular risk factors as well as age- and gender-matched 30 healthy individuals were included. We measured serum thiobarbituric acid-reactive substances (TBARS), malondialdehyde (MDA), advanced glycation end product (AGE), pentosidine, advanced oxidation protein products (AOPP), ADMA and CIMT in each subjects.


RESULTS
TBARS, MDA, AOPP, AGE, pentosidine and ADMA levels were significantly higher in PD patients than in controls (p < 0.001). CIMT in patients was higher than in the control group (0.83 +/- 0.09 vs. 0.77 +/- 0.06 mm; p < 0.01). CIMT was independently correlated with TBARS (beta = 0.33, p < 0.01), MDA (beta = 0.27, p < 0.01), AOPP (beta = 0.22, p < 0.02), AGE (beta = 0.45, p < 0.01), pentosidine (beta = 0.56, p < 0.01) and ADMA (beta = 0.54, p < 0.01).


CONCLUSIONS
OS markers and serum ADMA levels independently predict the CIMT level in PD patients.
Kocak
H
H
Department of Nephrology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Gumuslu
S
S
Ermis
C
C
Mahsereci
E
E
Sahin
E
E
Gocmen
A Y
AY
Ersoy
F
F
Suleymanlar
G
G
Yakupoglu
G
G
Tuncer
M
M
D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D010530:Peritoneal Dialysis; D011237:Predictive Value of Tests; D012307:Risk Factors; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D017539:Tunica Intima / Q000000981:diagnostic imaging; D014463:Ultrasonography
D015415:Biomarkers; D017127:Glycation End Products, Advanced; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde; C018524:N,N-dimethylarginine; D001120:Arginine