title: Phimotic ring topical corticoid cream (0.1% mometasone furoate) treatment in children.
abstract: OBJECTIVE
  Phimosis, owing to the presence of a preputial fibrotic ring, is surgically treated in 1% of children. During the last decade, however, topical steroid treatment has been proposed for phimosis.
  
  
  METHODS
  We present a double-blind study comparing 0.1% mometasone furoate topical cream vs moisturizing cream (placebo) for the treatment of phimosis. Children aged from 2 to 13 years (n = 110) presenting with phimosis (Kikiro's classification grade 5) and scheduled for circumcision were included in this trial. The patients were evaluated after 8 weeks of topical treatment with moisturizing cream (n = 54) or steroid cream (n = 56). Nonresponders from both groups received an additional 8 weeks of steroid cream treatment.
  
  
  RESULTS
  In the steroid group, the ring disappeared and glans exposure was obtained in 49 (88%) of 56 patients vs 28 (52%) of 54 patients in the placebo group (P < .05). After a second treatment, in the steroid group, 5 of the 7 patients were finally cured vs 22 of the 26 in the placebo group (P < .05). Two children with persisting phimosis (Kikiro's retractability grade 5 and appearance grade 3) in the steroid group (4%) vs 4 children in the placebo group (7%) ended up receiving postectomy.
  
  
  CONCLUSIONS
  The present investigation adds up and supports the effectiveness of phimosis topical corticoid treatment. Nevertheless, hygiene and preputial traction, when appropriately performed, seem to play an important role in the disappearance of the phimotic ring as well. New studies are necessary to confirm if this is true or not.
authors.affiliation: Department of Surgery and Anatomy, University of Sao Paolo, CEP 14049-900 Monte Alegre, Ribeirao Preto, Brazil. fopileggi@terra.com.br
authors.forename: Flavio de Oliveira
authors.initials: Fde O
authors.lastname: Pileggi
authors.forename: Yvonne A M V A
authors.initials: YA
authors.lastname: Vicente
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005355:Fibrosis; D006801:Humans; D008297:Male; D000068656:Mometasone Furoate; D009824:Ointments; D010688:Phimosis / Q000188:drug therapy* / Q000473:pathology; D011244:Pregnadienediols / Q000008:administration & dosage / Q000627:therapeutic use*; D012720:Severity of Illness Index
chemical_list: D009824:Ointments; D011244:Pregnadienediols; D000068656:Mometasone Furoate