[Application of computer image analysis for characterization of pellets].
The morphological characteristics of pellets are critical parameters, because of their physico-chemical features depend on the size, shape and surface geometric of the particles. To ensure the spherical shape and required particle of pharmaceutical pellets size is a prerequisite. The detailed technology is basic requirement for the successful and cost efficient production of particles of acceptable quality. Since the determination of the particle size is influenced by the particle shape, therefore microscopic examination is always suggested, which together with image analysis is suitable for the assesment of the most typical parameters. The method of the microscopic image analysis is useful not only for particle size measurement, but also for particle shape and texture evaluation, with a high sensitivity. Using the microscopic method particle shape may be defined either qualitatively and quantitatively. Reviewing the related articles and results on the investigation of sugar pellets demonstrate that roundness characterization is strongly influenced by the applied statistical shape parameters.
Balogh
Emese
E
Semmelweis Egyetem Gyógyszerészeti Intézet, Budapest, Hogyes Endre u 7 -- 1092.
Kállai
Nikolett
N
Dredán
Judit
J
Lengyel
Miléna
M
Klebovich
Imre
I
Antal
István
I
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004343:Drug Implants / Q000737:chemistry*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D010316:Particle Size; D015203:Reproducibility of Results
D004343:Drug Implants