title: [Two cases of pyogenic spondylitis with chronic hepatitis C during combination therapy of interferon alfa and ribavirin].
abstract: This report describes our experience with two cases of pyogenic spondylitis with chronic hepatitis C during combination therapy of interferon alfa and ribavirin. The first patient, a 59-year-old man, was treated conservatively and improved, but the second patient, a 69-year-old woman, was not improved by conservative therapy and reconstructive operation was performed. The combination therapy of interferon alfa and ribavirin has a high risk of severe infectious diseases as side effects. CT scan and MRI are recommended immediately to diagnose pyogenic spondylitis, when patients has pyrexia and lumbago with laboratory data suspected inflammation during interferon therapy.
authors.affiliation: Department of Gastroenterology, Yamagata University School of Medicine.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sugahara
authors.forename: Takafumi
authors.initials: T
authors.lastname: Saito
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Keiko
authors.initials: K
authors.lastname: Misawa
authors.forename: Rika
authors.initials: R
authors.lastname: Ishii
authors.forename: Akihiko
authors.initials: A
authors.lastname: Suzuki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Haga
authors.forename: Mai
authors.initials: M
authors.lastname: Sanjo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Okumoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nishise
authors.forename: Junitsu
authors.initials: J
authors.lastname: Ito
authors.forename: Koji
authors.initials: K
authors.lastname: Saito
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Togashi
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012254:Ribavirin / Q000009:adverse effects* / Q000627:therapeutic use; D013166:Spondylitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology / Q000601:surgery; D013203:Staphylococcal Infections; D013290:Streptococcal Infections; D013492:Suppuration; D016896:Treatment Outcome; D034363:Viridans Streptococci
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin