Diabetes and endometrial cancer: effect modification by body weight, physical activity and hypertension.
Among 777 endometrial cancer cases and 1550 controls from Italy and Switzerland, odds ratio was 1.7 (95% confidence interval: 1.2-2.5) for diabetes, and 5.1 for obese diabetic women as compared with non-obese non-diabetic ones. Diabetes shows a supramultiplicative effect with body mass index, but not with physical activity or hypertension.
Lucenteforte
E
E
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. lucenteforte@marionegri.it
Bosetti
C
C
Talamini
R
R
Montella
M
M
Zucchetto
A
A
Pelucchi
C
C
Franceschi
S
S
Negri
E
E
Levi
F
F
La Vecchia
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D001835:Body Weight; D015986:Confounding Factors, Epidemiologic; D048909:Diabetes Complications / Q000453:epidemiology*; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D013557:Switzerland / Q000453:epidemiology