Delirium following abrupt discontinuation of fluoxetine.
Sudden discontinuation of serotonin reuptake inhibitors (SRI) can lead to a number of psychological (e.g., nervousness, anxiety, crying spells, psychomotor agitation, irritability, depersonalization, decreased mood, memory disturbances, confusion, decreased concentration, and/or slowed thinking) and somatic (e.g., nausea, dizziness, headache) symptoms. Recent studies have shown that withdrawal symptoms are common with paroxetine, venlafaxine and fluvoxamine, but relatively rare and mild with fluoxetine cessation, likely as a result of its longer half-life. We report an unusual case of a patient who developed delirium after abrupt discontinuation of fluoxetine.
Blum
Diana
D
Stanford University, Department of Neurology, 300 Pasteur Drive Stanford, Rm. A343, CA 94305, United States. dblum@stanford.edu
Maldonado
José
J
Meyer
Everett
E
Lansberg
Maarten
M
D003693:Delirium / Q000139:chemically induced*; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis* / Q000209:etiology
D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors