title: High resolution image in bone biology I. Review of the literature.
abstract: Bone microstructure has usually been assessed by obtaining samples invasively and analyzing them with conventional histomorphometric methods. Improvements in high-resolution image acquisition systems have enabled non-invasive assessment of bone morphology and a more precise 3-D evaluation by means of "virtual biopsies", permitting bone assessment in regeneration or remodeling processes. This review describes the characteristics and limitations of bone assessment using different high-resolution image systems (synchrotron-radiation computed tomography, micro-computed tomography, acoustic scanning microscope; micro-magnetic resonance imaging). Morphometric variables that can be obtained from these images are reported and compared with conventional histomorphometric variables.
authors.affiliation: School of Dentistry, UCM, Madrid. jo.cano@wanadoo.es
authors.forename: Jorge
authors.initials: J
authors.lastname: Cano
authors.forename: Julián
authors.initials: J
authors.lastname: Campo
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Vaquero
authors.forename: Jose María
authors.initials: JM
authors.lastname: Martínez
authors.forename: Antonio
authors.initials: A
authors.lastname: Bascones
mesh_terms: D001842:Bone and Bones / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D033401:Microscopy, Acoustic; D014057:Tomography, X-Ray Computed