title: Potent oxindole based human beta3 adrenergic receptor agonists.
abstract: The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety.
authors.affiliation: Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
authors.forename: F Craig
authors.initials: FC
authors.lastname: Stevens
authors.forename: William E
authors.initials: WE
authors.lastname: Bloomquist
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Borel
authors.forename: Marlene L
authors.initials: ML
authors.lastname: Cohen
authors.forename: Christine A
authors.initials: CA
authors.lastname: Droste
authors.forename: Mark L
authors.initials: ML
authors.lastname: Heiman
authors.forename: Aidas
authors.initials: A
authors.lastname: Kriauciunas
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Sall
authors.forename: Frank C
authors.initials: FC
authors.lastname: Tinsley
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Jesudason
mesh_terms: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D000078183:Oxindoles; D051381:Rats; D020318:Rats, Long-Evans; D022702:Receptors, Adrenergic, beta-3 / Q000096:biosynthesis / Q000235:genetics; D013610:Tachycardia / Q000188:drug therapy*
chemical_list: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists; D007211:Indoles; D000078183:Oxindoles; D022702:Receptors, Adrenergic, beta-3; C022960:2-oxindole