title: Glycohemoglobin screening in adolescents attending to the Department of Paediatrics at a tertiary hospital in Turkey.
abstract: OBJECTIVE
  To investigate glycohemoglobin (HbAIc) levels in adolescents without diabetes, attending to our Adolescent Day Care Clinic.
  
  
  METHODS
  We studied on randomly selected 186 subjects aged between 9 and 18 years. HbA1c levels were measured in all subjects and those whose HbA1c levels >95th percentile were invited for oral glucose tolerance test (OGTT). Homeostasis of model assessment (HOMA-IR) value was used to define insulin resistance in subjects who underwent OGTT.
  
  
  RESULTS
  The median age of all subjects was 11 (min 9-max 18) years and 50.5% were boys. The median HbA1c level was higher in boys (5.2%; min 4.4-max 6.2) than girls (5.0%; min 4.0-max 6.4) (p=0.001). Fasting glucose was positively correlated to HbA1c (r=0.26, p=0.001). HOMA-IR values were >2.5 in six subjects and four of them were obese while two had impaired glucose tolerance. In multivariate analysis, it was observed that gender (boy) and high-fasting glucose levels were associated with high-HbA1c levels (OR 1.9, CI 95%: 1.0-3.4, p=0.02 and OR 1.1, CI 95%: 1.0-1.1, p=0.001, respectively).
  
  
  CONCLUSIONS
  We believe that routine HbA1c screening is not necessary for adolescents without diabetes. However screening may become desirable in the future at least for obese adolescents.
authors.affiliation: Department of Paediatrics, Ankara Training and Research Hospital, Ankara, Turkey. dilekdilli2@yahoo.com
authors.forename: Dilek
authors.initials: D
authors.lastname: Dilli
authors.forename: Ilknur
authors.initials: I
authors.lastname: Bostanci
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Dallar
authors.forename: Sabahat
authors.initials: S
authors.lastname: Gücük
mesh_terms: D000293:Adolescent; D016497:Adolescent Health Services; D001786:Blood Glucose / Q000032:analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002648:Child; D003920:Diabetes Mellitus / Q000453:epidemiology; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008487:Medical History Taking; D012727:Sex Characteristics; D014421:Turkey
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin