title: [Influence of varicocele on sperm chromatin structure and sperm motility].
abstract: OBJECTIVE
  To study the influence of varicocele on sperm chromatin structure and sperm motility.
  
  
  METHODS
  Routine semen analysis and sperm chromatin structure assay (SCSA) were performed in a varicocele group (n=74) and a control group (n=89).
  
  
  RESULTS
  Sperm concentration (41.4 +/- 38.7] x 10(6)/ml) grade a+b sperm percentage ([31.7 +/- 16.9]% and sperm viability ([62.8 +/- 22.2]%) in the varicocele group were evidently lower than those ([80.9 +/- 63.1] x 10(6)/ml, [46.8 +/- 20.5]%, [77.2 +/- 17.5])% in the control group (P < 0.05) and so were VCL, VSL and VAP ([37.4 +/- 12.5 microm/s, [23.4 +/- 7.8] microm/s, [26.5 +/- 8.2] microm/s) in the varicocele group than those ([42.4 +/- 10.7] microm/s, [27.3 +/- 7.3] microm/s, [30.7 +/- 7.8] microm/s) in the control (P < 0.05). MAD was increased (P < 0.01), and the COMP alphat of SCSA (23.2 +/-16.2) was obviously higher in the former than in the latter (14.1 +/- 11.8) (P < 0.05).
  
  
  CONCLUSIONS
  Varicocele causes damage to sperm DNA and changes sperm motility, which may result in male infertility.
authors.affiliation: Reproduction Centre, the 202nd Hospital of PLA, Shenyang, Liaoning 110003, China. yicongtang@hotmail.com
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.forename: Su-wen
authors.initials: SW
authors.lastname: Yan
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Meng-xing
authors.initials: MX
authors.lastname: Wang
authors.forename: Hai-ou
authors.initials: HO
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage; D006801:Humans; D008297:Male; D013076:Sperm Count; D013081:Sperm Motility / Q000235:genetics / Q000502:physiology*; D013094:Spermatozoa / Q000166:cytology / Q000378:metabolism*; D014646:Varicocele / Q000235:genetics / Q000503:physiopathology*
chemical_list: D002843:Chromatin