Risk of Clostridium difficile-associated disease among patients receiving proton-pump inhibitors in a Quebec medical intensive care unit.
Our study was conducted to determine whether use of gastric acid-suppressive agents increased the risk of Clostridium difficile-associated disease (CDAD) in a medical intensive care unit of one of the first hospitals to be threatened by the current CDAD epidemic in Quebec, Canada. Our findings suggest that efforts to determine risk factors for CDAD should focus on other areas, such as older age and antibiotic use.
Beaulieu
Mathieu
M
Faculty of Pharmacy, Universite de Montreal, Montreal, QC, H3C 3J7, Canada. mathieu.beaulieu@umontreal.ca
Williamson
David
D
Pichette
Gilbert
G
Lachaine
Jean
J
D018806:APACHE; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D016360:Clostridioides difficile; D015331:Cohort Studies; D004761:Enterocolitis, Pseudomembranous / Q000145:classification / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008297:Male; D054328:Proton Pump Inhibitors; D011792:Quebec / Q000453:epidemiology; D012307:Risk Factors
D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors