title: Magnetic resonance elastography of the brain.
abstract: The purpose of this study was to obtain normative data using magnetic resonance elastography (MRE) (a) to obtain estimates of the shear modulus of human cerebral tissue in vivo and (b) to assess a possible age dependence of the shear modulus of cerebral tissue in healthy adult volunteers. MR elastography studies were performed on tissue-simulating gelatin phantoms and 25 healthy adult volunteers. The data were analyzed using spatiotemporal filters and a local frequency estimating algorithm. Statistical analysis was performed using a paired t-test. The mean shear stiffness of cerebral white matter was 13.6 kPa (95% CI 12.3 to 14.8 kPa); while that of gray matter was lower at 5.22 kPa (95% CI 4.76 to 5.66 kPa). The difference was statistically significant (p<0.0001).
authors.affiliation: Mayo Clinic, Department of Radiology, 200 First Street Southwest, Rochester, MN 55905, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Kruse
authors.forename: Gregory H
authors.initials: GH
authors.lastname: Rose
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Glaser
authors.forename: Armando
authors.initials: A
authors.lastname: Manduca
authors.forename: Joel P
authors.initials: JP
authors.lastname: Felmlee
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
authors.forename: Richard L
authors.initials: RL
authors.lastname: Ehman
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D033081:Shear Strength; D013314:Stress, Mechanical