Primary cutaneous anaplastic large cell lymphoma associated with vascular endothelial growth factor arising from a burn scar.
We present a case of primary cutaneous anaplastic large cell lymphoma manifesting with widespread erythema around an ulcer. Skin biopsy from the ulcer showed CD30-positive atypical lymphocytes throughout the dermis, and immunostaining demonstrated that these cells produced vascular endothelial growth factor, a potent stimulus for angiogenesis. Skin biopsy from the erythema revealed rich neovascularization, which was probably associated with vascular endothelial growth factor.
Morihara
Kiyoshi
K
Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. moriyan@koto.kpu-m.ac.jp
Takenaka
Hideya
H
Morihara
Toru
T
Kishimoto
Saburo
S
D002056:Burns / Q000150:complications*; D002921:Cicatrix / Q000150:complications* / Q000209:etiology; D004890:Erythema / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D012883:Skin Ulcer / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D017730:Ki-1 Antigen; D042461:Vascular Endothelial Growth Factor A