Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals.
Msrs (methionine sulfoxide reductases), MsrA and MsrB, are repair enzymes that reduce methionine sulfoxide residues in oxidatively damaged proteins to methionine residues in a stereospecific manner. These enzymes protect cells from oxidative stress and have been implicated in delaying the aging process and progression of neurodegenerative diseases. In recent years, significant efforts have been made to explore the catalytic properties and physiological functions of these enzymes. In the current review, we present recent progress in this area, with the focus on mammalian MsrA and MsrBs including their roles in disease, evolution and function of selenoprotein forms of MsrA and MsrB, and the biochemistry of these enzymes.
Kim
Hwa-Young
HY
Department of Biochemistry and Molecular Biology, Aging-associated Vascular Disease Research Center, Yeungnam University College of Medicine, Daegu 705-717, South Korea. hykim@ynu.ac.kr
Gladyshev
Vadim N
VN
D000818:Animals; D000975:Antioxidants / Q000502:physiology*; D045643:DNA Repair Enzymes / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008322:Mammals / Q000378:metabolism*; D051150:Methionine Sulfoxide Reductases; D010088:Oxidoreductases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051140:Selenoproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D000975:Antioxidants; D007527:Isoenzymes; D051140:Selenoproteins; D010088:Oxidoreductases; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase; D045643:DNA Repair Enzymes