title: [Magnesium in skin allergy].
abstract: Magnesium is involved in many biological processes within the body. Magnesium deficiency causes many disorders, including impairment of immunity. This review summarizes present knowledge on the relationship between magnesium and skin allergy reactions. Special focus is on allergy types I and IV. At present the best knowledge is on allergy I. Magnesium deficiency in experimental animals, mainly rats, leads to characteristic hyperemia, an increase in IgE, neutrophilia and eosinophilia, an increase in the level of proinflammatory cytokines, mastocyte degranulation, histaminemia, and splenomegaly. These symptoms observed in hypomagnesemic rats are similar to those in atopic patients. Data on the relationship between magnesium and other types of allergy are scarce. Clinical observations show the beneficial effect of topical and oral administration of magnesium salts in patients with skin allergy. All the presented data point to an important role of magnesium in allergy reactions. Other studies are needed to better understand the mechanism of magnesium's action. Well-controlled clinical protocols should also be conducted to assess the efficiency of magnesium supplementation in patients with skin allergy.
authors.affiliation: Uniwersytet Przyrodniczy we Wrocławiu, Wydział Medycyny Weterynaryjnej, Katedra i Klinika Rozrodu, Chorób.
authors.forename: Joanna
authors.initials: J
authors.lastname: Błach
authors.forename: Wojciech
authors.initials: W
authors.lastname: Nowacki
authors.forename: Andrzej
authors.initials: A
authors.lastname: Mazur
mesh_terms: D000818:Animals; D018849:Controlled Clinical Trials as Topic; D016207:Cytokines / Q000097:blood; D019587:Dietary Supplements; D004802:Eosinophilia / Q000097:blood; D006632:Histamine / Q000097:blood; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000188:drug therapy / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000188:drug therapy / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D008274:Magnesium / Q000009:adverse effects / Q000276:immunology* / Q000494:pharmacology; D009504:Neutrophils / Q000276:immunology; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000276:immunology*; D012871:Skin Diseases / Q000188:drug therapy / Q000276:immunology*; D013163:Splenomegaly / Q000276:immunology; D014131:Trace Elements / Q000009:adverse effects / Q000276:immunology* / Q000494:pharmacology
chemical_list: D016207:Cytokines; D014131:Trace Elements; D007073:Immunoglobulin E; D006632:Histamine; D008274:Magnesium