title: [Variability of radiation-induced adaptive response in old age individuals and their correction by Peptide bioregulator -Livagen].
abstract: Effect of aging on adaptive response of cellular systems to low (stimulated) dozes of gamma-rays (0, 2 and 0, 5 Gy) and to disturbing dozes of radiation (1 and 2 Gy) has been investigated. PHA-stimulated cells were from 72-86 year-old individuals; control - 30-40 year-old individuals. The potentialities of induction of adaptive response in cells exposed to previously irradiated by stimulating dozes of gamma-rays with subsequent damaging effect of copper chloride (10(-3)M) has been investigated. The correcting activity of the peptide bioregulator Livagen was tested. The investigation showed that cells from aged individuals maintained radiation adaptive feature. Preliminary exposure to radiation caused stimulation of adaptive response in copper-treated cells. Corrective activity of Livagen was observed.
authors.forename: T A
authors.initials: TA
authors.lastname: Dzhokhadze
authors.forename: T Zh
authors.initials: TZh
authors.lastname: Buadze
authors.forename: N A
authors.initials: NA
authors.lastname: Dvalishvili
authors.forename: T A
authors.initials: TA
authors.lastname: Lezhava
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects* / Q000528:radiation effects; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D011836:Radiation Tolerance / Q000187:drug effects*; D011837:Radiation-Protective Agents / Q000494:pharmacology*
chemical_list: C473185:Livagen; D009842:Oligopeptides; D011837:Radiation-Protective Agents