title: Atypical glandular cells and adenocarcinoma in situ according to the Bethesda 2001 classification: cytohistological correlation and clinical implications.
abstract: BACKGROUND
  The objective of this study was to evaluate the correlation between the 2001 Bethesda classification of endocervical glandular abnormalities and histological diagnosis.
  
  
  METHODS
  A series of 155 women with endocervical glandular abnormalities on cervical smears were included: 91 with atypical glandular cells (AGC) not otherwise specified (NOS), 15 with AGC-favor neoplastic (FN); 35 with AGC associated with high-grade squamous intraepithelial lesion (HSIL) as combined diagnosis and 14 with adenocarcinoma in situ (AIS).
  
  
  RESULTS
  Histological outcome of squamous neoplasias (CIN 2 or worse) and adenocarcinoma were significantly associated with AGC-FN and AIS, taking as reference AGC-NOS, and more associated with AIS than AGC-FN. Similar associations were observed for histological outcome of adenocarcinoma, but no association was observed for only squamous neoplasia. Histological outcome of CIN2 or worse was strongly associated with AGC when HSIL was also present, but no association was observed with only for adenocarcinoma histological outcome.
  
  
  CONCLUSIONS
  AGC-NOS, AGC-FN and AIS cytological diagnosis represent a progressively increasing association with neoplastic diagnosis, due to progressively increasing association with adenocarcinoma. Histological outcome of squamous neoplasia is frequent but does not differ with these cytological interpretations. The presence of HSIL associated with AGC represents greater probability of squamous neoplasia but not adenocarcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Universidade Estadual de Campinas, Brazil.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Westin
authors.forename: Sophie F
authors.initials: SF
authors.lastname: Derchain
authors.forename: Silvia H
authors.initials: SH
authors.lastname: Rabelo-Santos
authors.forename: Liliana A
authors.initials: LA
authors.lastname: Angelo-Andrade
authors.forename: Luis O
authors.initials: LO
authors.lastname: Sarian
authors.forename: Eliane
authors.initials: E
authors.lastname: Oliveira
authors.forename: Luiz C
authors.initials: LC
authors.lastname: Zeferino
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014626:Vaginal Smears / Q000379:methods; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000473:pathology*