title: Diagnostic and prognostic markers for gastrointestinal stromal tumors in Norway.
abstract: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the gastrointestinal tract. The diagnosis of GIST is based on histology together with a panel of immunohistochemical markers; the most important is KIT (CD117). A total of 434 cases of GISTs were confirmed by histology and immunohistochemistry, and incorporated into tissue microarrays. Validation of histological features as well as the prognostic value of two immunohistochemical biomarkers (p16 and L1) was assessed. High mitotic rate, large tumor size, nuclear atypia, and small bowel primary site were all validated as negative prognostic factors in GISTs. Expression of p16 was significantly correlated with unfavorable prognosis, whereas L1 expression was not.
authors.affiliation: Department of Pathology, Institute of Medical Biology, University of Tromsø, Norway. sonja.steigen@unn.no
authors.forename: Sonja E
authors.initials: SE
authors.lastname: Steigen
authors.forename: Bodil
authors.initials: B
authors.lastname: Bjerkehagen
authors.forename: Hans K
authors.initials: HK
authors.lastname: Haugland
authors.forename: Ivar S
authors.initials: IS
authors.lastname: Nordrum
authors.forename: Else Marit
authors.initials: EM
authors.lastname: Løberg
authors.forename: Vidar
authors.initials: V
authors.lastname: Isaksen
authors.forename: Tor J
authors.initials: TJ
authors.lastname: Eide
authors.forename: Torsten O
authors.initials: TO
authors.lastname: Nielsen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002467:Cell Nucleus / Q000473:pathology; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000032:analysis*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000201:enzymology / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009664:Norway; D011379:Prognosis; D016016:Proportional Hazards Models; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis*; D015203:Reproducibility of Results; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16; D039841:Leukocyte L1 Antigen Complex; D019009:Proto-Oncogene Proteins c-kit