A lipid transfer protein that transfers lipid.
Very few lipid transfer proteins (LTPs) have been caught in the act of transferring lipids in vivo from a donor membrane to an acceptor membrane. Now, two studies (Halter, D., S. Neumann, S.M. van Dijk, J. Wolthoorn, A.M. de Maziere, O.V. Vieira, P. Mattjus, J. Klumperman, G. van Meer, and H. Sprong. 2007. J. Cell Biol. 179:101-115; D'Angelo, G., E. Polishchuk, G.D. Tullio, M. Santoro, A.D. Campli, A. Godi, G. West, J. Bielawski, C.C. Chuang, A.C. van der Spoel, et al. 2007. Nature. 449:62-67) agree that four-phosphate adaptor protein 2 (FAPP2) transfers glucosylceramide (GlcCer), a lipid that takes an unexpectedly circuitous route.
Levine
Tim P
TP
University College London Institute of Ophthalmology, London EC1V 9EL, England, UK. tim.levine@ucl.ac.uk
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005963:Glucosylceramides / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D008954:Models, Biological
D048868:Adaptor Proteins, Signal Transducing; D005963:Glucosylceramides; C487038:PLEKHA8 protein, human