title: [An analysis method to apply linkage disequilibrium maps to association study].
abstract: OBJECTIVE
  To apply linkage disequilibrium (LD) maps to associations studies with high throughput single nucleotide polymorphisms (SNPs).
  
  
  METHODS
  Seven hundred and fifty-four SNPs were genotyped in 160 Shanghai Chinese. LD maps were constructed in cases and controls separately. By comparing the decline of LD unit with distance between the two groups, disease susceptible loci were estimated. This method was compared with traditional analyses including LD analysis, single SNP and haplotype analyses.
  
  
  RESULTS
  The analysis of LD maps could detect the chromosome regions with different LD patterns between the cases and controls. The alleles and/or haplotypes frequencies of SNPs within the regions had significantly different distributions or trends of significantly different distributions.
  
  
  CONCLUSIONS
  This method may be applied to analyze the data from association studies with high throughput SNPs genotype information.
authors.affiliation: Shanghai Clinical Medicine Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated No.6 People's Hospital, Shanghai, 200233 PR China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Hu
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Jia
authors.forename: Cong-rong
authors.initials: CR
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Xiao-jing
authors.initials: XJ
authors.lastname: Ma
authors.forename: Qi-chen
authors.initials: QC
authors.lastname: Fang
authors.forename: Kun-san
authors.initials: KS
authors.lastname: Xiang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study / Q000379:methods*; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D000075062:Pre-B-Cell Leukemia Transcription Factor 1; D011518:Proto-Oncogene Proteins / Q000235:genetics; D047491:Retinoid X Receptor gamma / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D000075062:Pre-B-Cell Leukemia Transcription Factor 1; D011518:Proto-Oncogene Proteins; D047491:Retinoid X Receptor gamma; C083400:PBX1 protein, human