Iatrogenic botulism due to therapeutic botulinum toxin a injection in a pediatric patient.
Botulinum toxin A is commonly used to reduce spasticity and dystonia in children with cerebral palsy. We report a pediatric patient who developed systemic botulism as a result of a severe overdose of the injected toxin (40 U/kg). This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children.
Crowner
Beth E
BE
Program in Physical Therapy, Department of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA.
Brunstrom
Janice E
JE
Racette
Brad A
BA
D019274:Botulinum Toxins, Type A / Q000009:adverse effects*; D001906:Botulism / Q000139:chemically induced*; D002547:Cerebral Palsy / Q000188:drug therapy; D002675:Child, Preschool; D005260:Female; D006801:Humans
D019274:Botulinum Toxins, Type A