title: Pregnancy outcomes in patients with sickle cell disease in Enugu, Nigeria.
abstract: BACKGROUND
  Pregnancy in patients with sickle cell disease (SCD) is associated with increased maternal and foetal morbidity and mortality. The objective of this study was to review the pregnancy outcomes in patients with SCD as seen at the University of Nigeria Teaching Hospital(UNTH), Enugu, South-eastern Nigeria.
  
  
  METHODS
  This is a retrospective study. The data extracted from the patients' case files include the age, parity, gestational age at booking and complications of disease and pregnancy during the antenatal period, labour and puerperium. Fetal outcomes were also reviewed.
  
  
  RESULTS
  During the 30-year period under study (1975-2004), only 10 pregnant women with sickle cell disease were documented to have been attended to. Pregnancies were characterized by high maternal and fetal morbidity and mortality. Maternal complications identified were maternal mortality, lobar pneumonia, HIV and recurrent malaria infections, candidiasis, bone pain crises, haemolytic crises, pseudotoxaemia and pre-eclampsia. Fetal complications included intra-uterine fetal deaths, still births, low birth weights, and breech presentation.
  
  
  CONCLUSIONS
  From this study, it seems that female SCD patients present more rarely with pregnancy in South-eastern compared to South-western Nigeria. However, the spectrum of complications seen is similar to that recorded in other studies.
authors.affiliation: Department of Haematology & Immunology, University of Nigeria Teaching Hospital, Enugu, Nigeria. kcjsocheni@yahoo.com
authors.forename: S
authors.initials: S
authors.lastname: Ocheni
authors.forename: H E
authors.initials: HE
authors.lastname: Onah
authors.forename: O G
authors.initials: OG
authors.lastname: Ibegbulam
authors.forename: M I
authors.initials: MI
authors.lastname: Eze
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D009549:Nigeria / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000209:etiology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors