title: Characterization of language and reading skills in familial polymicrogyria.
abstract: Polymicrogyria (PMG) is a malformation of cortical development characterized by an excessive number of small gyri and abnormal cortical lamination, giving the cortical surface an irregular and gross appearance. The severity of clinical manifestations correlates with the extent of cortical involvement. The objective of the present study was to describe three families with linguistic features of developmental language disorder and reading impairment, and to establish a neuroanatomic correlation through neuroimaging. Subjects have been submitted to a comprehensive protocol including psychological assessment, language evaluation, neurological examination, and neuroimaging investigation. In our families, children usually had the diagnosis of developmental language disorder while adults had the diagnosis of reading impairment. MRI showed perisylvian polymicrogyria in several subjects of each family. Our data support the idea that there is a co-occurrence of developmental language disorder and reading impairment and both conditions may be associated with polymicrogyria.
authors.affiliation: Department of Neurology, FCM/Unicamp, Campinas, SP, Brazil.
authors.forename: Ecila Paula Mesquita
authors.initials: EP
authors.lastname: Oliveira
authors.forename: Simone Rocha Vasconcelos
authors.initials: SR
authors.lastname: Hage
authors.forename: Catarina Abraão
authors.initials: CA
authors.lastname: Guimarães
authors.forename: Iara
authors.initials: I
authors.lastname: Brandão-Almeida
authors.forename: Iscia
authors.initials: I
authors.lastname: Lopes-Cendes
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Guerreiro
authors.forename: Karine Couto Sarmento
authors.initials: KC
authors.lastname: Teixeira
authors.forename: Maria Augusta
authors.initials: MA
authors.lastname: Montenegro
authors.forename: Fernando
authors.initials: F
authors.lastname: Cendes
authors.forename: Marilisa Mantovani
authors.initials: MM
authors.lastname: Guerreiro
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000002:abnormalities*; D002648:Child; D004410:Dyslexia / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications* / Q000473:pathology*; D011446:Prospective Studies; D011932:Reading; D014888:Wechsler Scales