title: Reconstruction of the pelvic floor and perineum with human acellular dermal matrix and thigh flaps following pelvic exenteration.
abstract: BACKGROUND
  Patients who undergo pelvic floor resection as treatment for recurrent cancer following radiation therapy have increased rates of complications, particularly if permanent prosthetic mesh is used for reconstruction. Human acellular dermal matrix (HADM), commonly used for reconstruction in other torso locations, is associated with lower rates of complications (including infection, adhesions and cutaneous exposure) than synthetic mesh. We describe an effective technique to reconstruct the pelvic floor and perineum with HADM and thigh-based flaps following pelvic exenteration and radical vulvectomy.
  
  
  METHODS
  A 75-year-old woman underwent radical resection of the pelvic floor and perineum to treat recurrent vulvar squamous cell carcinoma and osteoradionecrosis. The pelvic floor and perineal soft tissue defect were reconstructed with HADM (AlloDerm; LifeCell Corporation, Branchburg, NJ) and bilateral, thigh-based tissue flaps, respectively. Despite a large resection, previous irradiation therapy and bacterial contamination the wounds healed without complications.
  
  
  CONCLUSIONS
  Reconstruction of pelvic floor defects using HADM is an option when wound conditions are unfavorable for the use of permanent prosthetic meshes.
authors.affiliation: Division of Plastic Surgery, University of Washington, Seattle, WA 98195, USA.
authors.forename: Hakim K
authors.initials: HK
authors.lastname: Said
authors.forename: Michael
authors.initials: M
authors.lastname: Bevers
authors.forename: Charles E
authors.initials: CE
authors.lastname: Butler
mesh_terms: D000368:Aged; D001672:Biocompatible Materials; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D003094:Collagen; D005260:Female; D006801:Humans; D010385:Pelvic Exenteration / Q000379:methods; D017773:Pelvic Floor / Q000601:surgery*; D010502:Perineum / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods; D013524:Surgical Flaps; D013526:Surgical Mesh; D014846:Vulvar Neoplasms / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D003094:Collagen