title: Spontaneous development and rupture of pulmonary artery aneurysm: a rare complication in an infant with peripheral pulmonary artery stenoses due to mutation of the elastin gene.
abstract: We present a 3-year-old boy with an elastin gene mutation and multiple peripheral pulmonary stenoses, who developed aneurysms of the pulmonary arteries spontaneously. We performed transcatheter occlusion of the aneurysms with detachable coils. While pulmonary arterial aneurysms may develop following pulmonary balloon angioplasty, spontaneous development is exceedingly rare. To the best of our knowledge, this is the first report describing spontaneous development of pulmonary artery aneurysms in a patient with peripheral pulmonary artery stenoses due to mutation of the elastin gene or Williams-Beuren syndrome.
authors.affiliation: Department of Pediatric Cardiology, University Children's Hospital, Tuebingen, Germany. christian.apitz@med.uni-tuebingen.de
authors.forename: Christian
authors.initials: C
authors.lastname: Apitz
authors.forename: Juergen
authors.initials: J
authors.lastname: Schaefer
authors.forename: Ludger
authors.initials: L
authors.lastname: Sieverding
authors.forename: Anita
authors.initials: A
authors.lastname: Rauch
authors.forename: Michael
authors.initials: M
authors.lastname: Hofbeck
mesh_terms: D017542:Aneurysm, Ruptured / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D000792:Angiography; D001157:Arterial Occlusive Diseases / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D006328:Cardiac Catheterization; D002675:Child, Preschool; D004247:DNA / Q000235:genetics*; D004549:Elastin / Q000235:genetics*; D004621:Embolization, Therapeutic / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009154:Mutation; D011651:Pulmonary Artery; D012422:Rupture, Spontaneous; D014057:Tomography, X-Ray Computed; D018980:Williams Syndrome / Q000150:complications* / Q000235:genetics / Q000378:metabolism
chemical_list: D004247:DNA; D004549:Elastin