title: Tris buffer (THAM). An appraisal of its physiologic effects and clinical usefulness.
abstract: It has been the purpose of this discussion to review critically the physiologic considerations and clinical evidence regarding the use of Tris buffer in the treatment of acid-base disorders. It is concluded that there is little current evidence, theoretical, experimental, or clinical, to support the view that Tris has a significant therapeutic role. Some possible exceptions to this general conclusion are considered.
authors.affiliation: Department of Medicine, Tufts University School of Medicine, Boston, USA.
authors.forename: H L
authors.initials: HL
authors.lastname: Bleich
authors.forename: W B
authors.initials: WB
authors.lastname: Schwartz
mesh_terms: D000138:Acidosis / Q000188:drug therapy*; D000142:Acidosis, Respiratory / Q000188:drug therapy; D000143:Acids / Q000506:poisoning*; D001793:Blood Preservation; D002021:Buffers; D019343:Citric Acid; D005947:Glucose / Q000031:analogs & derivatives; D006801:Humans; D011041:Poisoning / Q000188:drug therapy; D014325:Tromethamine / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000143:Acids; D002021:Buffers; D014325:Tromethamine; C002113:acid citrate dextrose; D019343:Citric Acid; D005947:Glucose