Epigenetics of antigen-receptor gene assembly.
The antigen receptor genes are organized into distinct DNA elements that encode the variable (V), diversity (D) and joining (J) regions. It is now well established that the rearrangement of antigen receptor genes is regulated by developmental-specific modulation of chromatin structure. Further studies involving statistical mechanics should provide physical insight into the physical mechanisms that underlie the association of antigen receptor gene segments.
Murre
Cornelis
C
Division of Biological Sciences, 03777, University of California, San Diego, La Jolla, CA 92093, United States. cmurre@ucsd.edu
D000818:Animals; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D011946:Receptors, Antigen / Q000235:genetics* / Q000378:metabolism
D011946:Receptors, Antigen