title: Crossover study of amlodipine versus nifedipine CR with home blood pressure monitoring via cellular phone: internet-mediated open-label crossover trial of calcium channel blockers for hypertension (i-TECHO trial).
abstract: OBJECTIVE
  We developed a new data collection system named i-converter that could transmit data to a website via cellular phone. Using the system, we compared the effects of two calcium channel blockers on the home blood pressure.
  
  
  METHODS
  Amlodipine and nifedipine CR were administered to 41 patients with essential hypertension for more than 6 weeks each in a randomized open-label crossover study. The dose of each drug was increased until the home blood pressure reached the target level of under 135/85 mmHg.
  
  
  RESULTS
  The morning home systolic and diastolic blood pressures were significantly lower during nifedipine CR treatment: 133 +/- 10/81 +/- 8 mmHg with amlodipine versus 131 +/- 8/80 +/- 8 mmHg with nifedipine CR, P < 0.05. The morning pulse rate was significantly higher during nifedipine CR treatment (69 +/- 9 beats/min with amlodipine versus 70 +/- 9 beats/min with nifedipine CR, P < 0.05). The evening home blood pressure and pulse rate, however, showed no significant differences between the two drugs (128 +/- 11/74 +/- 7 mmHg and 74 +/- 10 beats/min with amlodipine versus 128 +/- 10/75 +/- 7 mmHg and 74 +/- 9 beats/min with nifedipine CR, all not significant).
  
  
  CONCLUSIONS
  Nifedipine CR had a stronger antihypertensive effect than amlodipine during the critical morning period, but the morning pulse rate was higher. Our new data transmission system was effective for collecting precise data on the blood pressure and pulse rate via the internet.
authors.affiliation: Department of Internal Medicine, Kawasaki Municipal Ida Hospital, Kanagawa, Japan. ryuuzaki-m@city.kawasaki.jp
authors.forename: Munekazu
authors.initials: M
authors.lastname: Ryuzaki
authors.forename: Hidetomo
authors.initials: H
authors.lastname: Nakamoto
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nishida
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Sone
authors.forename: Sadao
authors.initials: S
authors.lastname: Nakajima
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Yoshimoto
authors.forename: Yuka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Kaori
authors.initials: K
authors.lastname: Itagaki
mesh_terms: D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000627:therapeutic use*; D001795:Blood Pressure Determination; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D040421:Cell Phone; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D020407:Internet; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D011674:Pulse; D017216:Telemedicine
chemical_list: D002121:Calcium Channel Blockers; D017311:Amlodipine; D009543:Nifedipine