title: An esterase-activated magnetic resonance contrast agent.
abstract: A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO(3)(-)/CO(3)(2-) binding by the resulting negative charge.
authors.affiliation: Department of Chemistry, University Road, University of Leicester, Leicester, UK LE1 7RH.
authors.forename: Marco
authors.initials: M
authors.lastname: Giardiello
authors.forename: Mark P
authors.initials: MP
authors.lastname: Lowe
authors.forename: Mauro
authors.initials: M
authors.lastname: Botta
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry*; D004950:Esterases / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013552:Swine; D014867:Water / Q000737:chemistry
chemical_list: D003287:Contrast Media; D014867:Water; D004950:Esterases