title: Familial history of cancer and childhood acute leukemia: a French population-based case-control study.
abstract: A case-control study was conducted to investigate the role of a familial history of cancer in the etiology of childhood acute leukemia. The history of cancer in the relatives of 472 cases was compared with that of 567 population-based controls. Recruitment was frequency matched on age, sex and region. The familial history of cancer in each child's relatives was reported by the mother in response to a standardized self-administered questionnaire. A familial history of solid tumor in first or second-degree relatives was associated with an increased risk of acute lymphoblastic leukemia (odds ratio (OR)=1.6 [95% confidence interval, 1.2-2.1]), while a familial history of hematopoietic malignancies in first or second-degree relatives was associated with an increased risk of acute myeloid leukemia (OR=4.3 [1.4-13]). The ORs for the histories of cancer increased with the number of relatives with cancer (OR=1.5 [1.1-2.0] for one relative and OR=2.3 [1.3-3.8] for two relatives or more; Ptrend<0.0001). Significant associations between childhood acute leukemia and familial history of genital cancers and brain tumor were also observed (OR=2.7 [1.2-5.8] and OR=10.7 [1.3-86], respectively). This study supports the hypothesis that a familial history of cancer may play a role in the etiology of childhood acute leukemia. It also evidences some specific associations that require further investigation.
authors.affiliation: INSERM, U754, IFR69, Villejuif, France.
authors.forename: Mahaut
authors.initials: M
authors.lastname: Ripert
authors.forename: Florence
authors.initials: F
authors.lastname: Menegaux
authors.forename: Yves
authors.initials: Y
authors.lastname: Perel
authors.forename: Françoise
authors.initials: F
authors.lastname: Méchinaud
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Plouvier
authors.forename: Virginie
authors.initials: V
authors.lastname: Gandemer
authors.forename: Patrick
authors.initials: P
authors.lastname: Lutz
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vannier
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Lamagnére
authors.forename: Geneviève
authors.initials: G
authors.lastname: Margueritte
authors.forename: Patrick
authors.initials: P
authors.lastname: Boutard
authors.forename: Alain
authors.initials: A
authors.lastname: Robert
authors.forename: Corinne
authors.initials: C
authors.lastname: Armari-Alla
authors.forename: Martine
authors.initials: M
authors.lastname: Munzer
authors.forename: Frédéric
authors.initials: F
authors.lastname: Millot
authors.forename: Lionel
authors.initials: L
authors.lastname: de Lumley
authors.forename: Christian
authors.initials: C
authors.lastname: Berthou
authors.forename: Xavier
authors.initials: X
authors.lastname: Rialland
authors.forename: Brigitte
authors.initials: B
authors.lastname: Pautard
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Clavel
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005190:Family; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000235:genetics*; D008297:Male; D009369:Neoplasms / Q000235:genetics*