title: Metabolism of benzo[a]pyrene in peroxynitrite/Fe(III) porphyrin system.
abstract: The peroxynitrite/porphyrin biomimetic system was established to investigate the effects of peroxynitrite on benzo[a]pyrene (B[a]P) metabolism. Three model systems consisting of different iron porphyrins were compared, and the results showed that the peroxynitrite/T(p-Cl)PPFeCl system was the highest catalytic efficiency in the metabolism of B[a]P. We analyzed the B[a]P metabolites produced from this system by RP-HPLC method and firstly identified the formation of nitrobenzo[a]pyrenes which are the special metabolites of B[a]P induced by peroxynitrite.
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China. luoyj@bjut.edu.cn
authors.forename: Yun-jing
authors.initials: YJ
authors.lastname: Luo
authors.forename: Tai-feng
authors.initials: TF
authors.lastname: Lin
authors.forename: Shu-fen
authors.initials: SF
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Ru-gang
authors.initials: RG
authors.lastname: Zhong
mesh_terms: D001564:Benzo(a)pyrene / Q000737:chemistry / Q000378:metabolism*; D004785:Environmental Pollutants / Q000737:chemistry / Q000378:metabolism; D009153:Mutagens / Q000737:chemistry / Q000378:metabolism; D016877:Oxidants / Q000737:chemistry / Q000378:metabolism*; D030421:Peroxynitrous Acid / Q000737:chemistry / Q000378:metabolism*; D011166:Porphyrins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004785:Environmental Pollutants; D009153:Mutagens; D016877:Oxidants; D011166:Porphyrins; D030421:Peroxynitrous Acid; D001564:Benzo(a)pyrene