Life style-related diseases of the digestive system: endocrine disruptors stimulate lipid accumulation in target cells related to metabolic syndrome.
Many reports indicated that endocrine disruptors (EDs) affect several hormonal functions in various living things. Here, we show the effect of EDs on lipid accumulation in target cells involved in the onset of metabolic syndrome. Treatment with nonylphenol and bisphenol A, typical EDs, stimulated the accumulation of triacylglycerol in differentiated adipocytes from 3T3-L1, preadipocytes, in time- and concentration-dependent manners. Up-regulation of gene expressions involved in lipid metabolism and metabolic syndrome were observed in adipocytes treated with EDs. Similarly, stimulatory effects of EDs were also observed on the human hepatoma cell line HuH-7. These observations indicate that exposure to EDs stimulates the lipid accumulation in target cells involved in the metabolic syndrome and may cause the dysfunction of those cells, resulting in induction of metabolic syndrome.
Wada
Koichiro
K
Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan. kwada@dent.osaka-u.ac.jp
Sakamoto
Hirotada
H
Nishikawa
Kenji
K
Sakuma
Satoru
S
Nakajima
Atsushi
A
Fujimoto
Yohko
Y
Kamisaki
Yoshinori
Y
D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D045744:Cell Line, Tumor; D052244:Endocrine Disruptors / Q000633:toxicity*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D024821:Metabolic Syndrome / Q000209:etiology*; D051379:Mice; D014280:Triglycerides / Q000378:metabolism*; D015854:Up-Regulation
D052244:Endocrine Disruptors; D014280:Triglycerides