Iterative approach to polyketide-type structures: stereoselective synthesis of 1,3-polyols utilizing the catalytic asymmetric Overman esterification.
An iterative systematic approach to the 1,3-polyol motif has been developed to provide access to all possible stereoisomers by utilizing the catalytic asymmetric Overman esterification for the construction of all stereogenic centres.
Binder
Jörg T
JT
Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany.
Kirsch
Stefan F
SF
D002384:Catalysis; D004951:Esterification; D018942:Macrolides / Q000737:chemistry*; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D018942:Macrolides; D011108:Polymers; C024617:polyol