Emerging technologies for the molecular study of infertility, and potential clinical applications.
The techniques currently used to treat infertility cases are quite limited in their capabilities, due to an incomplete understanding of the molecular activities of germ cells. Fortunately, several technologies are presently being researched that should aid the understanding of the various molecular causes of germ cell pathologies. This review discusses microarray technology, proteomics, metabolic profiling, the PolScope, atomic force microscopy and microfluidics. These technologies have all seen success in preliminary studies, and promise directly or indirectly to improve the low success rates of IVF and other related therapies. However, their widespread use in laboratories and clinics may not be seen until preliminary studies confirming their safety and effectiveness are published, and until standardized protocols for their utilization are established.
Varghese
Alex C
AC
DeCode Life Foundation, Kolkata, India. Agarwaa@ccf.org
Goldberg
Eric
E
Bhattacharyya
Asok K
AK
Agarwal
Ashok
A
D020869:Gene Expression Profiling; D006801:Humans; D007246:Infertility / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D044085:Microfluidics; D018625:Microscopy, Atomic Force; D008859:Microscopy, Polarization; D025202:Molecular Diagnostic Techniques; D020411:Oligonucleotide Array Sequence Analysis; D040901:Proteomics