Effect of hydroalcoholic extract of Zingiber officinalis rhizomes on LPS-induced rat airway hyperreactivity and lung inflammation.
Ginger, the rhizome of Zingiber officinalis Roscoe (Zingiberaceae), is a common constituent of diets around the world and its extracts have been reported to exhibit several pharmacological activities. We investigated the effect of crude hydroalcoholic extract of ginger on the rat trachea hyperreactivity (RTHR) and lung inflammation induced by lipopolysaccharide (LPS). Our results demonstrate that ginger extract and celecoxib attenuated RTHR 90 min and 48 h after LPS. Ginger and celecoxib reduced the serum level of prostaglandin (PGE2) and thromboxane (TXA2) 90 min after LPS. Celecoxib and ginger also reduced myeloperoxidase activity and the number of cells in rat bronchoalveolar lavage 48 h post-LPS. On lung parenchyma, ginger and celecoxib reduced the release of PGE2 and TXA2 48 h post-LPS. These results suggest that ginger exerts an anti-inflammatory effect on lung attenuating RTHR and COX metabolites seem to be involved in these processes.
Aimbire
F
F
Laboratory of Animal Experimental, Research and Development Institute, University of Valley of Paraíba, Av. Shishima Hifumi, 2911 Urbanova, 12244-000 São José dos Campos, SP, Brazil. aimbire@univap.br
Penna
S C
SC
Rodrigues
M
M
Rodrigues
K C
KC
Lopes-Martins
R A B
RA
Sertié
J A A
JA
D000818:Animals; D016535:Bronchial Hyperreactivity / Q000139:chemically induced / Q000188:drug therapy*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D000068579:Celecoxib; D015232:Dinoprostone / Q000097:blood; D020939:Zingiber officinale / Q000737:chemistry*; D008070:Lipopolysaccharides; D008297:Male; D009637:Masoprocol / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011014:Pneumonia / Q000139:chemically induced / Q000188:drug therapy*; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome / Q000737:chemistry; D013449:Sulfonamides / Q000494:pharmacology; D013928:Thromboxane A2 / Q000097:blood; D014132:Trachea / Q000187:drug effects / Q000503:physiopathology*
D008070:Lipopolysaccharides; D010936:Plant Extracts; D011720:Pyrazoles; D013449:Sulfonamides; D013928:Thromboxane A2; D009637:Masoprocol; D000068579:Celecoxib; D015232:Dinoprostone