Silencing insulin resistance through SIRT1.
Insulin resistance is an important risk factor for the development of type 2 diabetes and the metabolic syndrome. A new study in this issue of Cell Metabolism (Sun et al., 2007) shows that SIRT1, a mammalian sirtuin homolog and histone deacetylase, can ameliorate insulin resistance by silencing expression of protein tyrosine phosphatase 1B, a major negative regulator of insulin action.
Zabolotny
Janice M
JM
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. jzabolot@bidmc.harvard.edu
Kim
Young-Bum
YB
D015536:Down-Regulation; D020868:Gene Silencing; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000235:genetics*; D056564:Sirtuin 1; D037761:Sirtuins / Q000378:metabolism*
D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins