title: Susceptibility of bacterial pathogens against lincomycin/spectinomycin (1/2), penicillin G/neomycin (1/1), and penicillin G/dihydrostreptomycin (1/1) as determined in the BfT-GermVet monitoring program 2004-2006.
abstract: A total of 368 bacterial pathogens, including 72 coagulase-positive and coagulase-variable staphylococci, 97 beta-haemolytic streptococci, 51 Escherichia coli, 75 Pasteurella multocida, 25 Mannheimia haemolytica, 25 Pseudomonas aeruginosa, and 23 Arcanobacterium pyogenes, were investigated for their susceptibility to the three combinations of antimicrobial agents lincomycin/spectinomycin (1/2), penicillin G/neomycin (1/1), and penicillin G/dihydrostreptomycin (1/1) in comparison to their susceptibility to the corresponding single substances. When comparing the minimum inhibitory concentrations (MICs) determined for any of the three combinations with those for the single substances, the lowest MIC of one of the two substances usually determined the MIC of the combination.This observation was made for all three combinations and all bacterial pathogens tested.Thus, it is assumed that the combination of lincomycin with spectinomycin as well as that of penicillin with either neomycin or dihydrostreptomycin resulted in an extended spectrum of target bacterial pathogens rather than in an increase in antimicrobial efficacy.
authors.affiliation: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft, Neustadt-Mariensee. stefan.schwarz@fal.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwarz
authors.forename: Christiane
authors.initials: C
authors.lastname: Werckenthin
authors.forename: Eva
authors.initials: E
authors.lastname: Alesík
authors.forename: Lothar H
authors.initials: LH
authors.lastname: Wieler
authors.forename: Jürgen
authors.initials: J
authors.lastname: Wallmann
mesh_terms: D000820:Animal Diseases / Q000188:drug therapy* / Q000382:microbiology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D002415:Cats; D002417:Cattle; D004096:Dihydrostreptomycin Sulfate / Q000494:pharmacology; D004285:Dogs; D004359:Drug Therapy, Combination; D005858:Germany; D006078:Government Programs; D008034:Lincomycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009355:Neomycin / Q000494:pharmacology; D010400:Penicillin G / Q000494:pharmacology; D000198:Spectinomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000198:Spectinomycin; D008034:Lincomycin; D009355:Neomycin; D010400:Penicillin G; D004096:Dihydrostreptomycin Sulfate