Human adipose tissue-derived mesenchymal stromal cells as salvage therapy for treatment of severe refractory acute graft-vs.-host disease in two children.
Severe GVHD is a lethal complication to ASCT, and a number of approaches are therefore being evaluated. Recently, Le Blanc et al. reported a case of grade IV therapy-resistant acute GVHD of the gut and liver that showed rapid improvement after infusion of mesenchymal stem cells. Here we describe two pediatric patients who developed severe refractory acute GVHD following ASCT and were successfully treated with AMSC from HLA-mismatched unrelated donors.
Fang
Baijun
B
Henan Institute of Haematology, Henan Tumor Hospital, Zhengzhou, China.
Song
Yongping
Y
Lin
Quande
Q
Zhang
Yanli
Y
Cao
Ying
Y
Zhao
Robert Chunhua
RC
Ma
Yuanfang
Y
D000273:Adipose Tissue; D000293:Adolescent; D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D008648:Mesoderm / Q000637:transplantation*; D010677:Philadelphia Chromosome; D017154:Stromal Cells / Q000637:transplantation*; D014184:Transplantation, Homologous / Q000009:adverse effects*
D007166:Immunosuppressive Agents