[Involvement of striatal serotonin in fluoxetine effects on adrenocortical function and behaviour].
Treatment of the adult rats with selective serotonin (5-HT) reuptake inhibitor: fluoxetine and its complexes with glycyrrizhinic acid during 2 weeks (25 mg/kg/day) significantly increased plasma corticosterone levels that were measured after 5-min plus-maze. All the drugs decreased the content of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the striatum as well as 5-HT in the hippocampus. There was a significant negative correlation between 5-HT in the striatum and corticosterone levels. These data suggest that fluoxetine induces serotoninergic changes in the striatum that might be related to neuroendocrine and behavioural effects of the drug.
Shishkina
G T
GT
Bulygina
V V
VV
Iudina
A M
AM
Tolstikova
T G
TG
Dygalo
N N
NN
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D005473:Fluoxetine / Q000737:chemistry / Q000494:pharmacology*; D019695:Glycyrrhizic Acid / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry / Q000494:pharmacology*
D003345:Corticosterone; D005473:Fluoxetine; D019695:Glycyrrhizic Acid; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors