Stimulatory effect of N-(1-deoxy-beta-d-fructopyranos-1-yl)-l-proline on antibody production in mice.
Synthesized N-(1-deoxy-beta-d-fructopyranos-1-yl)-l-proline (Fru-Pro), an Amadori rearrangement product, has been investigated for its immunomodulatory effects. We evaluated the effects of Fru-Pro on the in vivo and in vitro activity in the regulation of the mice immune response. Haemagglutination antibody titre, plaque forming cell assay, E-rosette forming assay and cytotoxic test were studied. It has been demonstrated that the compound shows immunostimulating properties. In conclusion, present investigation suggests that the Fru-Pro is biologically functional, improves the immune system and might be regarded as an immune response modulator.
Tarnawski
Mirosław
M
Torf Corporation - Pharmaceutical Factory Ltd., 11 Fabryczna St., 55 080 Katy Wrocławskie, Poland. m.tarnawski@torf.pl
Kuliś-Orzechowska
Renata
R
Szelepin
Bogdan
B
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives; D005947:Glucose / Q000737:chemistry; D006388:Hemagglutinins / Q000276:immunology; D006854:Hydrocortisone / Q000494:pharmacology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009005:Monosaccharides / Q000138:chemical synthesis / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012397:Rosette Formation; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D014611:Vaccination
D000276:Adjuvants, Immunologic; D006388:Hemagglutinins; D007075:Immunoglobulin M; D009005:Monosaccharides; C525600:N-(1-deoxy-beta-d-fructopyranos-1-yl)-l-proline; D005632:Fructose; D011392:Proline; D005947:Glucose; D006854:Hydrocortisone