title: Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study.
abstract: The synthesis, characterization and liposome insertion of a novel magnesium(II) carboranyl-porphyrazine, i.e. [2,3,7,8,12,13,17,18-octakis-(1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20-porphyrazine]magnesium(II) complex, MgHECSPz, are described. MgHECSPz was designed to improve the potentiality in multiple approach anticancer therapy. Liposomal formulations with different surface charge were prepared as delivering agents. The obtained loaded vectors were characterized by DLS, SAXS, SANS and zeta potential measurements in order to define the overall properties and structural details of loaded liposomes.
authors.affiliation: University of Firenze, Department of Chemistry, Via della Lastruccia 3, 50019, Sesto Fiorentino (FI), Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Salvati
authors.forename: Sandra
authors.initials: S
authors.lastname: Ristori
authors.forename: Daniela
authors.initials: D
authors.lastname: Pietrangeli
authors.forename: Julian
authors.initials: J
authors.lastname: Oberdisse
authors.forename: Luca
authors.initials: L
authors.lastname: Calamai
authors.forename: Giacomo
authors.initials: G
authors.lastname: Martini
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Ricciardi
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D008564:Membrane Potentials; D008665:Metalloporphyrins / Q000138:chemical synthesis / Q000737:chemistry*; D033363:Neutron Diffraction; D010714:Phosphatidylethanolamines / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction
chemical_list: C525973:(2,3,7,8,12,13,17,18-octakis-(1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20-porphyrazine)magnesium(II); C410262:1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine; D004337:Drug Carriers; D005229:Fatty Acids, Monounsaturated; D008081:Liposomes; D008665:Metalloporphyrins; D010714:Phosphatidylethanolamines; D000644:Quaternary Ammonium Compounds; C070046:1,2-dioleoyloxy-3-(trimethylammonium)propane