title: Electrochromatographic separation on a poly(dimethylsiloxane)/glass chip by integration of a capillary containing an acrylate monolithic stationary phase.
abstract: In this paper, we present an approach to perform electrochromatographic separations on poly(dimethylsiloxane) chips: a fused-silica capillary containing a stationary phase was introduced directly into the chip. This approach would offer great flexibility since capillary modification methods are well known, and thus, with this kind of chip, different microfluidic devices having various functions could be prepared. Electrophoretic separations were first achieved by integrating an empty capillary into the chip to evaluate the analytical performances of this system. They were compared to those obtained with a classical chip. Finally, an electrochromatographic separation involving a capillary containing a hexyl acrylate-based monolith was performed. These preliminary results show this approach to be promising.
authors.affiliation: Laboratoire des Sciences Analytiques, UMR 5180 CNRS-Université Lyon I, Villeurbanne, France.
authors.forename: Maximilien
authors.initials: M
authors.lastname: Blas
authors.forename: Nathalie
authors.initials: N
authors.lastname: Delaunay
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Rocca
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000596:Amino Acids / Q000032:analysis; D053801:Capillary Electrochromatography / Q000295:instrumentation* / Q000379:methods; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D010316:Particle Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry; D012828:Silicones / Q000737:chemistry*; D013499:Surface Properties; D013997:Time Factors
chemical_list: D000179:Acrylates; D000596:Amino Acids; D004129:Dimethylpolysiloxanes; D012828:Silicones; C013830:baysilon; D012822:Silicon Dioxide; C036658:acrylic acid