[Developmental neurotoxicity of industrial chemicals].
"A Silent Pandemic : Industrial Chemicals Are Impairing the Brain Development of Children Worldwide" Fetal and early childhood exposures to industrial chemicals in the environment can damage the developing brain and can lead to neurodevelopmental disorders (NDDs)--autism, attention deficit disorder (ADHD), and mental retardation. In a new review study, published in The Lancet, Philip Grandjean and Philip Landrigan from the Harvard School of Public Health systematically examined publicly available data on chemical toxicity in order to identify the industrial chemicals that are the most likely to damage the developing brain. The researchers found that 202 industrial chemicals have the capacity to damage the human brain, and they conclude that chemical pollution may have harmed the brains of millions of children worldwide. The authors conclude further that the toxic effects of industrial chemicals on children have generally been overlooked. In North Amercia, the commission for environmental cooperation, and in European Union the DEVNERTOX projects had reached to the same conclusions. We analyse this review and discuss these rather pessimistic conclusions.
Labie
Dominique
D
Département de génétique, développement et pathologie moléculaire, Institut Cochin, 24, rue du Faubourg Saint-Jacques, 75014 Paris, France. labie@cochin.inserm.fr
D000328:Adult; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology / Q000254:growth & development; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000139:chemically induced* / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D006219:Halogens / Q000633:toxicity; D015386:Hazardous Substances / Q000633:toxicity*; D006801:Humans; D007220:Industrial Waste / Q000009:adverse effects*; D007223:Infant; D007854:Lead / Q000633:toxicity; D008345:Manganese / Q000633:toxicity; D008767:Methylmercury Compounds / Q000633:toxicity; D020258:Neurotoxicity Syndromes / Q000453:epidemiology / Q000209:etiology*; D010575:Pesticides / Q000633:toxicity; D011078:Polychlorinated Biphenyls / Q000633:toxicity; D012997:Solvents / Q000633:toxicity; D018675:Toxicity Tests
D006219:Halogens; D015386:Hazardous Substances; D007220:Industrial Waste; D008767:Methylmercury Compounds; D010575:Pesticides; D012997:Solvents; D007854:Lead; D008345:Manganese; D011078:Polychlorinated Biphenyls