title: Changing of antioxidant enzyme activity on the biliary obstructed rats treated with resveratrol.
abstract: The aim of this study was to evaluate the role of antioxidant enzyme activity and nitric oxide levels induced by 28 day biliary obstruction in the rat. A total of 21 young Swiss albino rats were divided in to 3 groups. Bile duct ligations, bile duct ligations plus resveratrol, sham operated. Bile duct ligations plus resveratrol group received 10 mg/kg dose of resveratrol intraperitonealy once daily throughout for 28 days. Liver damage and cholestasis were determined by biochemical examination. SOD, CAT and GSH-PX activity decreased in BDL group compared with shame opareted groups (p < 0.001). NO levels increased in BDL groups compared with shame opareted groups (p < 0.001). SOD, CAT and GSH-PX activity was found higher in BDL+resveratrol treated groups than BDL groups (p < 0.001). In addition this NO levels decreased in BDL+resveratrol treated groups than BDL groups (p < 0.001). In conclusion, it is thought that resveratrol may be used as a protective agent in biliary obstructions; however, further clinical and experimental studies are needed to verify its antioxidative and hepatoprotective effects.
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, Ondokuzmayis University, Samsun, Turkey. scenesiz@omu.edu.tr
authors.forename: S
authors.initials: S
authors.lastname: Cenesiz
authors.forename: G F
authors.initials: GF
authors.lastname: Yarim
authors.forename: A B
authors.initials: AB
authors.lastname: Karabulut
authors.forename: C
authors.initials: C
authors.lastname: Ara
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001652:Bile Ducts / Q000601:surgery; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000188:drug therapy / Q000201:enzymology / Q000662:veterinary*; D004912:Erythrocytes / Q000201:enzymology; D008026:Ligation / Q000662:veterinary; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D010088:Oxidoreductases / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D009569:Nitric Oxide; D010088:Oxidoreductases; D000077185:Resveratrol; D001663:Bilirubin