Genetic control of immune response in carriers of the 8.1 ancestral haplotype: correlation with levels of IgG subclasses: its relevance in the pathogenesis of autoimmune diseases.
Ancestral haplotype (AH) 8.1(HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201) seems to be associated with susceptibility to autoimmune diseases. Different mechanisms are probably involved in increasing autoimmunity, such as unbalanced cytokine production and the lack of C4A protein. So AH 8.1 modifies immune response in many ways. In this study we demonstrate that IgG2 serum levels were significantly lower in 8.1 AH carriers than in 8.1 AH non-carriers. On the contrary, as regards IgG1, IgG3, IgG4 serum levels, no significant differences were observed between the two groups. In AH 8.1 carriers low IgG2 levels might take to slower clearance of the infectious agent and hence to a lasting presence of it. The persistence of infectious antigens could determine an increased production of autoantibodies with a higher risk of cross-reactions.
Candore
Giuseppina
G
Laboratorio di Immunopatologia, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Corso Tukory 211, 90134 Palermo, Italy. gcandore@unipa.it
Campagna
Anna Maria
AM
Cuppari
Irene
I
Di Carlo
Daniele
D
Mineo
Claudia
C
Caruso
Calogero
C
D000328:Adult; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D015795:HLA-B8 Antigen / Q000097:blood / Q000145:classification / Q000276:immunology; D015803:HLA-DR3 Antigen / Q000097:blood / Q000145:classification / Q000276:immunology; D006239:Haplotypes / Q000235:genetics* / Q000276:immunology*; D006579:Heterozygote; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D007074:Immunoglobulin G