Noninvasive photoacoustic tomography of human peripheral joints toward diagnosis of inflammatory arthritis.
The feasibility of photoacoustic tomography (PAT) in imaging human peripheral joints in a noninvasive manner was demonstrated through studies of cadaver human fingers. Based on the intrinsic optical contrast, intra- and extra-articular tissue structures in the finger at the levels of the joints were visualized successfully with satisfactory spatial resolution. The imaging depth of PAT in the near-infrared region enables the cross-sectional imaging of a human finger as a whole organ. As a novel technology with unique advantages, PAT holds promise for early diagnosis of inflammatory joint disorders and accurate monitoring of disease progression and response to therapy.
Wang
Xueding
X
Department of Radiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA. xdwang@umich.edu
Chamberland
David L
DL
Jamadar
David A
DA
D001168:Arthritis / Q000473:pathology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005384:Finger Joint / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000295:instrumentation*; D014463:Ultrasonography / Q000295:instrumentation*