In vitro and in vivo antiplasmodial activity of 'saye', an herbal remedy used in Burkina Faso traditional medicine.
'Saye', a traditional medicine used in Burkina Faso, which consists of extracts of Cochlospermum planchonii (rhizome), Cassia alata (leaf) and Phyllanthus amarus (whole plant), showed a significant effect against Plasmodium falciparum and Plasmodium berghei parasites grown in vivo (IC(50) = 80.11 +/- 3.40 microg/mL; ED(50) = 112.78 +/- 32.32 mg/kg). In vitro the activity was lower.
Traoré
M
M
Direction Régionale de l'Institut de Recherche en Sciences de la Santé (IRSS-DRO/CNRST), BP 545 Bobo-Dioulasso, Burkina Faso. traore_maminata@yahoo.fr
Diallo
A
A
Nikièma
J B
JB
Tinto
H
H
Dakuyo
Z P
ZP
Ouédraogo
J B
JB
Guissou
I P
IP
Guiguemdé
T R
TR
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D002050:Burkina Faso; D008288:Malaria / Q000469:parasitology / Q000517:prevention & control*; D016778:Malaria, Falciparum / Q000469:parasitology / Q000517:prevention & control; D016488:Medicine, African Traditional; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D010962:Plasmodium berghei / Q000187:drug effects*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials