Late-onset epileptogenesis and seizure genesis: lessons from models of cerebral ischemia.
Patients surviving ischemic stroke often express delayed epileptic syndromes. Late poststroke seizures occur after a latency period lasting from several months to years after the insult. These seizures might result from ischemia-induced neuronal death and associated morphological and physiological changes that are only partly elucidated. This review summarizes the long-term morphofunctional alterations observed in animal models of both focal and global ischemia that could explain late-onset seizures and epileptogenesis. In particular, this review emphasizes the change in GABAergic and glutamatergic signaling leading to hyperexcitability and seizure genesis.
Epsztein
Jérôme
J
Institut de Neurobiologie de la Méditerranée, Institut National de la Santé et de la Recherche Médicale Unité 29, and Université de La Méditerranée, Marseille Cedex, France.
Ben-Ari
Yehezkel
Y
Represa
Alfonso
A
Crépel
Valérie
V
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007395:Interneurons / Q000473:pathology; D051381:Rats; D012640:Seizures / Q000473:pathology / Q000503:physiopathology*