Enantioselective synthesis of the alcohol moiety of dolabriferol.
Dolabriferol is a marine polypropionate characterized by an unusual noncontiguous carbon backbone. The two polypropionate subunits are linked by an ester function. The protected alcohol moiety of dolabriferol was synthesized via the enzymatic desymmetrization of meso-(anti-anti)-2,4-dimethyl-1,3,5-pentanetriol.
Pelchat
Nicholas
N
Département de chimie, CREFSIP, Faculté des sciences et de génie, Université Laval, Québec, Canada, G1K 7P4.
Caron
Dave
D
Chênevert
Robert
R
D020650:Combinatorial Chemistry Techniques; D008968:Molecular Conformation; D000439:Pentanols / Q000737:chemistry*; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000439:Pentanols; D011714:Pyrans; C516274:dolabriferol; C525406:meso-(anti-anti)-2,4-dimethyl-1,3,5-pentanetriol