Supervisory and routine processes in noun and verb generation in nondemented patients with Parkinson's disease.
Despite the increased comprehension of the role of the basal ganglia in cognitive functions such as learning, attention, and executive functions, the exact implication of these structures in language remains unclear. A specific role of basal ganglia in language has been proposed. Nonetheless, a recent hypothesis gives the basal ganglia a non-language specific role in the inhibition of competing alternatives during later controlled processes of language production. In this study we assessed the production of both nouns and verbs in a population of 20 nondemented patients with Parkinson's disease (NDPD). Aspects of selection demands and stimulus-response association strength were investigated in both tasks. Performance of NDPD patients was compared with that of 20 matched elderly subjects. An impairment in verb production was found in PD patients. A selection effect on verb production was found in PD patients along with a greater effect of stimulus-response association strength. PD patients had the greatest difficulty in situations of weak stimulus-response association strength. A "Task-Relevant-Response" analysis carried out on stimuli (nouns) in condition of free association suggested that verb production happens in the context of strongly activated nouns. This means that, in order to produce a verb a switch has to be done from a task irrelevant to a task relevant response. Our results are in line with the proposed non-language specific involvement of the basal ganglia in the supervisory rather than the routine semantic processes required during lexical retrieval.
Crescentini
Cristiano
C
International School for Advanced Studies SISSA-ISAS, Via Beirut, 2-4, 34014, Trieste, Italy. crescentini@sissa.it
Mondolo
Federica
F
Biasutti
Emanuele
E
Shallice
Tim
T
D000368:Aged; D000704:Analysis of Variance; D001245:Association Learning / Q000502:physiology; D001479:Basal Ganglia / Q000502:physiology* / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007802:Language; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012660:Semantics; D012720:Severity of Illness Index; D014706:Verbal Learning / Q000502:physiology*