title: Garlic (Allium sativum L.) as a potential antidote for cadmium and lead intoxication: cadmium and lead distribution and analysis in different mice organs.
abstract: Analysis and distribution of Pb and Cd in different mice organs including liver, kidney, spleen, heart and blood were evaluated after treatment with different aqueous concentrations of garlic (12.5-100 mg/l). Atomic absorption spectrometry (AAS) was used for analysis of Pb and Cd in these organs. Treatment of Cd-Pb exposed mice with garlic (12.5-100 mg/l) reduced Pb concentrations by 44.65, 42.61, 38.4, 47.56, and 66.62% in liver, kidney, heart, spleen and blood respectively. Moreover, garlic reduced Cd levels by 72.5, 87.7, 92.6, 95.6, and 71.7% in liver, kidney, heart, spleen and blood respectively. The suppressed immune responses in mice pretreated with Cd-Pb mixture were reversed by 48.85, 55.82, 81.4 and 90.7 in the presence of 100, 50, 25, and 12.5 mg/ml of garlic extract.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. massadeh@just.edu.jo
authors.forename: A M
authors.initials: AM
authors.lastname: Massadeh
authors.forename: S A
authors.initials: SA
authors.lastname: Al-Safi
authors.forename: I F
authors.initials: IF
authors.lastname: Momani
authors.forename: A A
authors.initials: AA
authors.lastname: Alomary
authors.forename: Q M
authors.initials: QM
authors.lastname: Jaradat
authors.forename: A S
authors.initials: AS
authors.lastname: AlKofahi
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002104:Cadmium / Q000493:pharmacokinetics*; D002105:Cadmium Poisoning / Q000188:drug therapy*; D005260:Female; D005737:Garlic; D007854:Lead / Q000493:pharmacokinetics*; D007855:Lead Poisoning / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D010936:Plant Extracts; D002104:Cadmium; D007854:Lead