title: [Association of regulatory genes polymorphisms with aerobic and anaerobic performance of athletes].
abstract: The aim of study was to investigate an allelic distribution of PPARA (G/C polymorphism), PPARG (Pro/Ala), PPARD (+294T/C) and PGCIA (Gly482Ser) genes in rowers (n=205) and controls (n=659), and to find correlation between genotypes and physiological parameters. Genotyping was performed by restriction fragment length polymorphism analysis. Physiological parameters were evaluated by PM 3 Rower Ergometer and MetaMax 3B Gas Analyzer. The frequencies ofPPARA G (90.1% vs. 83.6%) and PPARG Ala (23.1% vs. 16.2%) alleles in elite athletes, and of PPARD C (19.1% vs. 10.5%) and PGC1A Gly (75.4% vs. 66.5%) alleles in sub-elite athletes were significantly higher than in controls. Moreover, PPARA G (when oxygen pulse was measured) and PGC 1A Gly (when maximal aerobic power and anaerobic threshold (%) of VO2max were measured) alleles were associated with high values of aerobic performance. Thus, PPARA G, PPARG Ala, PPARD C and PGCIA Gly alleles can be considered as genetic markers associated with enhanced physical performance.
authors.forename: I I
authors.initials: II
authors.lastname: Akhmetov
authors.forename: D V
authors.initials: DV
authors.lastname: Popov
authors.forename: I A
authors.initials: IA
authors.lastname: Mozhaĭskaia
authors.forename: S S
authors.initials: SS
authors.lastname: Missina
authors.forename: I V
authors.initials: IV
authors.lastname: Astratenkova
authors.forename: O L
authors.initials: OL
authors.lastname: Vinogradova
authors.forename: V A
authors.initials: VA
authors.lastname: Rogozkin
mesh_terms: D000293:Adolescent; D000328:Adult; D000332:Aerobiosis; D015308:Anaerobic Threshold / Q000235:genetics*; D000693:Anaerobiosis; D005260:Female; D005787:Gene Frequency; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics*; D010807:Physical Endurance / Q000235:genetics*; D011110:Polymorphism, Genetic; D013177:Sports; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D006360:Heat-Shock Proteins; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D047492:Peroxisome Proliferator-Activated Receptors; D014157:Transcription Factors