title: [Study of intracerebral focus changes on CADASIL by using MR imaging].
abstract: OBJECTIVE
  To investigate dynamic changes of intracerebral focus on cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
  
  
  METHODS
  Using the modified Scheltens scale, the magnetic resonance (MR) changes of lesion distribution, size and shape in 7 patients from a CADASIL family were retrospectively analyzed during 3 years observed.
  
  
  RESULTS
  In 6 of 7 patients, the number and volume of lesion areas in the white matter were increased (parietal lobe, n = 6; temporal lobe, n = 5; frontal lobe, n = 3; occipital lobe, n = 2) and some areas even became confluent as a mass or chain. New lacunar infarcts (n = 1 - 5) appeared in 5 patients and the arcuate fiber were involved in 1 patients. Slight enlargement could be seen in lateral ventricle (n = 1) or lateral ventricle with third ventricle (n = 1).
  
  
  CONCLUSIONS
  MR imaging can help us to reveal dynamic changes of brain lesions and prognosis in patients with CADASIL.
authors.affiliation: Department of Radiology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Jian-ce
authors.initials: JC
authors.lastname: Li
authors.forename: De-xin
authors.initials: DX
authors.lastname: Jin
authors.forename: Yun-jun
authors.initials: YJ
authors.lastname: Yang
authors.forename: Xiu-yun
authors.initials: XY
authors.lastname: Chen
authors.forename: Jin-lin
authors.initials: JL
authors.lastname: Li
authors.forename: Mei-hao
authors.initials: MH
authors.lastname: Wang
authors.forename: En-fu
authors.initials: EF
authors.lastname: Wu
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D020520:Brain Infarction / Q000473:pathology; D046589:CADASIL / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies