YhbO protects cells against multiple stresses.
YhbO is a member of the DJ-1/ThiJ/Pfp1 superfamily, which includes chaperones, peptidases, and the Parkinson's disease protein DJ-1. A yhbO-disrupted mutant of Escherichia coli is highly sensitive to oxidative, thermal, UV, and pH stresses, and the putative nucleophilic cysteine C104 of YhbO is required for stress resistance. These results suggest that YhbO affects a central process in stress management.
Abdallah
Jad
J
Stress Molecules, Institut Jacques Monod, Université Paris 7, 2 Place Jussieu, 75005 Paris, France.
Caldas
Teresa
T
Kthiri
Fatoum
F
Kern
Renée
R
Richarme
Gilbert
G
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003545:Cysteine / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000502:physiology* / Q000528:radiation effects; D029968:Escherichia coli Proteins / Q000235:genetics / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000235:genetics / Q000502:physiology*; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D016254:Mutagenesis, Insertional; D016877:Oxidants / Q000494:pharmacology; D014466:Ultraviolet Rays
D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins; D016877:Oxidants; C513540:YhbO protein, E coli; D003545:Cysteine