title: [Age-related characteristics of relationships between brain blood flow, liquor dynamics and biomechanical properties of human cranium].
abstract: The peculiarities of relationships between changes of cerebral blood flow, intracranial liquor dynamics and skull biomechanics in humans were studied in an age aspect. For this aim, a non-invasive method was proposed based on concomitant registration of rheoencephalogram and transcranial dopplerogram and evaluation of relationships between intracranial volume and pulse pressure changes (P-V index). The data obtained were analyzed by pattern-phase computer processing and compared with the blood flow parameters. The investigation was carried out on healthy volunteers of 18-25, 40-50 and 65-75 years of age. It was shown that circulatory-metabolic supplying of human brain was supported by such factors as volume brain blood flow, intracranial liquor dynamics in cooperation with skull biomechanics. The cerebral blood flow decrease at aging could be compensated by increase of the reserve-compensatory abilities of the system of cranial-spinal liquor dynamics.
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Moskalenko
authors.forename: G B
authors.initials: GB
authors.lastname: Weinstein
authors.forename: P
authors.initials: P
authors.lastname: Halvorson
authors.forename: T I
authors.initials: TI
authors.lastname: Kravchenko
authors.forename: A
authors.initials: A
authors.lastname: Feidling
authors.forename: N A
authors.initials: NA
authors.lastname: Riabchikova
authors.forename: V N
authors.initials: VN
authors.lastname: Semernia
authors.forename: A A
authors.initials: AA
authors.lastname: Panov
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000134:cerebrospinal fluid / Q000502:physiology; D001696:Biomechanical Phenomena; D001921:Brain / Q000098:blood supply / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004569:Electroencephalography; D006801:Humans; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging*; D010992:Plethysmography, Impedance; D012886:Skull / Q000502:physiology*; D017585:Ultrasonography, Doppler, Transcranial