The association of opium with coronary artery disease.
BACKGROUND
The effects of opium consumption on coronary artery disease are still unknown.


METHODS
A cross-sectional study was conducted on 2405 patients admitted to the Angiographic Ward at Tehran Heart Center from 7 May 2005 to 13 August 2005.


RESULTS
After adjusting for conventional cardiovascular risk factors, opium consumption was a significant risk factor for coronary artery disease (P=0.01 and odds ratio=1.8). Moreover, the amount of opium consumption was associated significantly with the severity of coronary atherosclerosis, as measured by clinical vessel score (r=0.2, P=0.002).


CONCLUSIONS
To our knowledge, this is the first time that the adverse effects of opium consumption on coronary arteries was defined.
Sadeghian
Saeed
S
Tehran Heart Center, Tehran University of Medical Sciences, Jalal AL-Ahmad & North Kargar Cross, Tehran, Iran. sadeghian15@yahoo.com
Darvish
Soodabeh
S
Davoodi
Gholamreza
G
Salarifar
Mojtaba
M
Mahmoodian
Mehran
M
Fallah
Nader
N
Karimi
Abbas Ali
AA
D000368:Aged; D003327:Coronary Disease / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009892:Opium / Q000009:adverse effects*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D019966:Substance-Related Disorders
D009892:Opium