Natural IgM-mediated innate autoimmunity: a new target for early intervention of ischemia-reperfusion injury.
Recent studies showed that innate autoimmunity is an early mechanism for ischemia-reperfusion (I/R) injury. Results from different animal models showed that reperfusion of ischemic tissues elicits an acute inflammatory response involving a complement system, which is activated by autoreactive natural IgM. Moreover, ischemia-specific self-targets were identified. In contrast to the unsuccessful attempts in the past to treat I/R injury, targeting natural IgM-mediated innate autoimmunity may open a new avenue for early intervention.
Zhang
Ming
M
SUNY-Downstate Medical Center, Department of Anesthesiology, 450 Clarkson Avenue, Brooklyn, NY 11203, USA. ming.zhang@downstate.edu
Carroll
Michael C
MC
D000818:Animals; D015551:Autoimmunity; D003167:Complement Activation; D006801:Humans; D007113:Immunity, Innate; D007075:Immunoglobulin M / Q000097:blood*; D007167:Immunotherapy / Q000379:methods*; D015427:Reperfusion Injury / Q000276:immunology* / Q000628:therapy
D007075:Immunoglobulin M