title: The UGT2B17 gene deletion polymorphism and risk of prostate cancer. A case-control study in Caucasians.
abstract: BACKGROUND
  UDP-glucuronosyltransferase (UGT) 2B17 is a phase II metabolizing enzyme that mediates the glucuronidation of C(19) steroids. A deletion polymorphism in the UGT2B17 gene is associated with a substantial reduction in glucuronidation activity in vitro.
  
  
  METHODS
  We examined the association between the UGT2B17 deletion polymorphism and the risk of incident prostate cancer in a population-based study from central Arkansas that included 411 Caucasian cases and 397 Caucasian controls. We developed a novel high-throughput procedure that uses real-time PCR and allelic discrimination for genotyping analysis.
  
  
  RESULTS
  The prevalence of the UGT2B17 deletion [(0/0)] was 12% in the controls, which was consistent with previous population estimates and with Hardy Weinberg equilibrium. There was no association between the UGT2B17 deletion polymorphism and prostate cancer risk in unconditional logistic regression analysis. Compared to the wild-type group (+/+), the adjusted odds ratio (OR) was 0.89 (95% CI=0.55-1.45) for the homozygous deletion (0/0), and the OR was 0.99 (95% CI=0.73-1.35) for the heterozygote group (+/0).
  
  
  CONCLUSIONS
  These findings show that the UGT2B17 deletion polymorphism is not associated with prostate cancer risk in Caucasians.
authors.affiliation: Departments of Public Health Sciences, Penn State Hershey Medical Center, Hershey, PA 17033, USA.
authors.forename: Carla J
authors.initials: CJ
authors.lastname: Gallagher
authors.forename: Fred F
authors.initials: FF
authors.lastname: Kadlubar
authors.forename: Joshua E
authors.initials: JE
authors.lastname: Muscat
authors.forename: Christine B
authors.initials: CB
authors.lastname: Ambrosone
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Lang
authors.forename: Philip
authors.initials: P
authors.lastname: Lazarus
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D017353:Gene Deletion; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015778:Minor Histocompatibility Antigens; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics*; D012306:Risk; D044465:White People / Q000235:genetics
chemical_list: D015778:Minor Histocompatibility Antigens; D014453:Glucuronosyltransferase; C500513:UGT2B17 protein, human