title: Noninvasive photoacoustic tomography of human peripheral joints toward diagnosis of inflammatory arthritis.
abstract: The feasibility of photoacoustic tomography (PAT) in imaging human peripheral joints in a noninvasive manner was demonstrated through studies of cadaver human fingers. Based on the intrinsic optical contrast, intra- and extra-articular tissue structures in the finger at the levels of the joints were visualized successfully with satisfactory spatial resolution. The imaging depth of PAT in the near-infrared region enables the cross-sectional imaging of a human finger as a whole organ. As a novel technology with unique advantages, PAT holds promise for early diagnosis of inflammatory joint disorders and accurate monitoring of disease progression and response to therapy.
authors.affiliation: Department of Radiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA. xdwang@umich.edu
authors.forename: Xueding
authors.initials: X
authors.lastname: Wang
authors.forename: David L
authors.initials: DL
authors.lastname: Chamberland
authors.forename: David A
authors.initials: DA
authors.lastname: Jamadar
mesh_terms: D001168:Arthritis / Q000473:pathology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005384:Finger Joint / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000295:instrumentation*; D014463:Ultrasonography / Q000295:instrumentation*