G'rab'bing the microenvironment for invasion.
Transformation and metastasis require cell invasion. In this issue of Developmental Cell, Caswell et al. describe a unique mechanism regulating tumor cell invasion. The authors report that an interaction between beta1 integrin and Rab25, a GTPase that has been linked to tumor aggressiveness and metastasis, regulates the recycling of alpha5beta1 integrin to the leading edge of cell pseudopodia.
Weaver
Valerie
V
Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA 94143, USA. weaverv@surgery.ucsf.edu
Werb
Zena
Z
D000818:Animals; D045744:Cell Line, Tumor; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D039081:Integrin alpha5beta1 / Q000378:metabolism / Q000502:physiology*; D009361:Neoplasm Invasiveness; D011485:Protein Binding; D021381:Protein Transport; D011554:Pseudopodia / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000502:physiology*
D039081:Integrin alpha5beta1; C509763:Rab25 protein, human; D020691:rab GTP-Binding Proteins