title: Fusion and molecular aspects of liposomal nanocarriers incorporated with isoprenoids.
abstract: The present study was conducted to investigate whether typical isoprenyl compounds (TICs) can control liposomal fusion reactions through changes in the physical properties of membranes. The fusion capabilities of TIC-incorporated liposomes were characterized by measuring the 13C spin-lattice relaxation times (13CT1) and the gel permeation chromatogram (GPC) patterns. The 13CT1 relaxivities of some of these TIC-liposomes were remarkably enhanced at 27 degrees C. The highest 13CT1 value obtained was for the beta-carotene-liposome, which ruptured, and was attributed to the highest membrane fusion reactivity. The other TIC-liposomes incorporated with alpha-tocopherol, canthaxanthin, or coenzyme Q10 also induced significant fusion and did not rupture in comparison with the beta-carotene-liposome. These results show that the incorporations of TICs into lipid bilayers are useful to control liposomal nanocarriers for suitable membrane packing and advantageous phase separation, which could affect membrane-related processes.
authors.affiliation: Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan. hnakagawa@medes.m.u-tokyo.ac.jp
authors.forename: Hidenori
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shiina
authors.forename: Masaki
authors.initials: M
authors.lastname: Sekino
authors.forename: Makoto
authors.initials: M
authors.lastname: Kotani
authors.forename: Shoogo
authors.initials: S
authors.lastname: Ueno
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008560:Membrane Fluidity; D008561:Membrane Fusion; D008968:Molecular Conformation; D010316:Particle Size; D013729:Terpenes / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D008051:Lipid Bilayers; D008081:Liposomes; D013729:Terpenes