Renewed hope for a vaccine against the intestinal adult Taenia solium.
Review of experimental and observational evidence about various cestode infections of mammalian hosts revives hope for the development of an effective vaccine against adult intestinal tapeworms, the central protagonists in their transmission dynamics. As for Taenia solium, there are abundant immunological data regarding cysticercosis in humans and pigs, but information about human taeniasis is scarce. A single publication reporting protection against T. solium taeniasis by experimental primo infection and by vaccination of an experimental foster host, the immunocompetent female hamster, kindles the hope of a vaccine against the tapeworm to be used in humans, its only natural definitive host.
Sciutto
Edda
E
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, DF México. edda@servidor.unam.mx
Rosas
Gabriela
G
Cruz-Revilla
Carmen
C
Toledo
Andrea
A
Cervantes
Jacquelynne
J
Hernández
Marisela
M
Hernándezt
Beatríz
B
Goldbaum
Fernando A
FA
de Aluja
Aline S
AS
Fragoso
Gladis
G
Larralde
Carlos
C
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D002353:Carrier State / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000517:prevention & control*; D041201:Taenia solium / Q000276:immunology*; D013622:Taeniasis / Q000188:drug therapy / Q000517:prevention & control*; D014612:Vaccines
D000871:Anthelmintics; D014612:Vaccines