HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population.
The heat shock 60-kDa protein 1 (HSP60) is involved in immune and inflammatory reactions, which are hallmarks of rheumatoid arthritis (RA). HSP60 is encoded by the HSPD1 gene located on 2q33, one of the suggested RA susceptibility loci in the French Caucasian population. Our aim was to test whether HSPD1 is a major susceptibility gene by studing families from the French Caucasian population. Three single nucleotide polymorphisms (SNPs) were studied in 100 RA trio families, and 100 other families were used for replication. Genetic analyses were performed by comparing allelic frequencies, by applying the transmission disequilibrium test, and by assessing the genotype relative risk. We observed a significant RA association for the C/C genotype of rs2340690 in the first sample. However, this association was not confirmed when the second sample was added. The two other SNPs and the haplotype analysis did not give any significant results. We conclude that HSPD1 is not a major RA susceptibility gene in the French Caucasian population.
Jacq
Laurent
L
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France. Laurent@polyarthrite.net.|Hôpital Sud Francilien, 59 bd Henri Dunant, 91100, Corbeil-Essonnes, France. Laurent@polyarthrite.net.
Teixeira
Vitor Hugo
VH
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.|Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Garnier
Sophie
S
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Michou
Laëtitia
L
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Dieudé
Philippe
P
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.|Hôpital Bichat, AP-HP, 46 rue Henri Huchart, 75018, Paris, France.
Rocha
Dominique
D
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Pierlot
Céline
C
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Lemaire
Isabelle
I
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.|Hôpital Sud Francilien, 59 bd Henri Dunant, 91100, Corbeil-Essonnes, France.
Quillet
Patrick
P
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.|Hôpital Sud Francilien, 59 bd Henri Dunant, 91100, Corbeil-Essonnes, France.
Hilliquin
Pascal
P
Hôpital Sud Francilien, 59 bd Henri Dunant, 91100, Corbeil-Essonnes, France.
Mbarek
Hamdi
H
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Petit-Teixeira
Elisabeth
E
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
Cornélis
François
F
GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.|Hôpital Sud Francilien, 59 bd Henri Dunant, 91100, Corbeil-Essonnes, France.|Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75010, Paris, France.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D018834:Chaperonin 60; D018833:Chaperonins / Q000235:genetics*; D005192:Family Health; D005260:Female; D005602:France / Q000208:ethnology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D024101:Mitochondrial Proteins; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics*
D018834:Chaperonin 60; C060293:HSPD1 protein, human; D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D018833:Chaperonins