title: Wolfram syndrome: case report and review of the literature.
abstract: Wolfram syndrome (WFS) is a rare diffuse neurodegenerative disorder characterized by diabetes insipidus, diabetes mellitus, optic atrophy, deafness, and a wide variety of central nervous system abnormalities. Insulin-dependent diabetes mellitus with optic nerve atrophy is sufficient criteria for the diagnosis. WFS is a devastating disease for the patients and their families. This study emphasizes the need for careful evaluation of cases having insulin-dependent diabetes mellitus and optic atrophy.
authors.affiliation: Department of Opthalmology, Diyarbakir State Hospital, Diyarbakir, Turkey. sari@dicle.edu.tr
authors.forename: Seyhmus
authors.initials: S
authors.lastname: Ari
authors.forename: Uğur
authors.initials: U
authors.lastname: Keklíkçí
authors.forename: Ihsan
authors.initials: I
authors.lastname: Caça
authors.forename: Kaan
authors.initials: K
authors.lastname: Unlü
authors.forename: Hasan
authors.initials: H
authors.lastname: Kayabaşi
mesh_terms: D000293:Adolescent; D003638:Deafness / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D009896:Optic Atrophy / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D014929:Wolfram Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology