title: CD44 involvement in autoimmune inflammations: the lesson to be learned from CD44-targeting by antibody or from knockout mice.
abstract: CD44 is a multistructural and multifunctional glycoprotein, the diversity of which is generated by alternative splicing. In this communication we review some aspects related to CD44 structure and function in experimental autoimmune inflammation, focusing on research performed in our own laboratory. We have found that CD44 targeting by antibody, passively injected into DBA/1 mice with collagen-induced arthritis (CIA) and NOD mice with type I diabetes or actively generated by CD44 cDNA vaccination of SJL/j mice with autoimmune encephalomyelitis, markedly reduced the pathological manifestations of these diseases by attenuating cell migration of the inflammatory cells and/or by their apoptotic killing. However, genetic deletion of CD44 by knockout technology enhanced the development of CIA because of molecular redundancy mediated by RHAMM (a receptor of hyaluronan-mediated motility). The mechanisms that stand behind these findings are discussed.
authors.affiliation: The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. naord@md.huji.ac.il
authors.forename: David
authors.initials: D
authors.lastname: Naor
authors.forename: Shlomo
authors.initials: S
authors.lastname: Nedvetzki
authors.forename: Marita
authors.initials: M
authors.lastname: Walmsley
authors.forename: Avner
authors.initials: A
authors.lastname: Yayon
authors.forename: Eva A
authors.initials: EA
authors.lastname: Turley
authors.forename: Ira
authors.initials: I
authors.lastname: Golan
authors.forename: Dan
authors.initials: D
authors.lastname: Caspi
authors.forename: Lora Eshkar
authors.initials: LE
authors.lastname: Sebban
authors.forename: Yehiel
authors.initials: Y
authors.lastname: Zick
authors.forename: Tali
authors.initials: T
authors.lastname: Garin
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Karussis
authors.forename: Nathalie
authors.initials: N
authors.lastname: Assayag-Asherie
authors.forename: Itamar
authors.initials: I
authors.lastname: Raz
authors.forename: Lola
authors.initials: L
authors.lastname: Weiss
authors.forename: Shimon
authors.initials: S
authors.lastname: Slavin
authors.forename: Itshak
authors.initials: I
authors.lastname: Golan
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000276:immunology* / Q000378:metabolism*; D003094:Collagen / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D018960:Hyaluronan Receptors / Q000276:immunology* / Q000378:metabolism*; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout
chemical_list: D000906:Antibodies; D018960:Hyaluronan Receptors; D003094:Collagen