title: Effects of sequence disorder on DNA looping and cyclization.
abstract: Effects of sequence disorder on looping and cyclization of the double-stranded DNA are studied theoretically. Both random intrinsic curvature and inhomogeneous bending rigidity are found to result in a remarkably wide distribution of cyclization probabilities. For short DNA segments, the range of the distribution reaches several orders of magnitude for even completely random sequences. The ensemble averaged values of the cyclization probability are also calculated, and the connection to the recent experiments is discussed.
authors.affiliation: Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA. yopopov@mrl.ucsb.edu
authors.forename: Yuri O
authors.initials: YO
authors.lastname: Popov
authors.forename: Alexei V
authors.initials: AV
authors.lastname: Tkachenko
mesh_terms: D001703:Biophysics / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D019143:Evolution, Molecular; D015233:Models, Statistical; D008962:Models, Theoretical; D009690:Nucleic Acid Conformation; D011336:Probability; D015203:Reproducibility of Results
chemical_list: D004247:DNA