title: Preliminary evaluation of antimicrobial activity of diastereomeric cis/trans-3-aryl(heteroaryl)-3,4-dihydroisocoumarin-4-carboxylic acids.
abstract: Preliminary differentiating screening of the antibacterial and antifungal activity of a series of diastereomeric cis/trans-3-aryl(heteroaryl)-3,4-dihydroisocoumarin-4-carboxylic acids (3a-i) was performed by the agar diffusion method against twelve microorganism strains of different taxonomic groups. S. aureus and A. niger were the most sensitive strains to the antibiotic effect of the tested compounds, both inhibited by 10 of 12 compounds. The most potent antibacterial agent was cis-3-phenyl-3,4-dihydroisocoumarin-4-carboxylic acid (cis-3a), exhibiting activity against all seven bacterial test strains.
authors.affiliation: Faculty of Chemistry, Sofia University, 1, J. Bourchier Blvd., 1164 Sofia, Bulgaria. mbogdanov@chem.uni-sofia.bg
authors.forename: Milen G
authors.initials: MG
authors.lastname: Bogdanov
authors.forename: Meglena I
authors.initials: MI
authors.lastname: Kandinska
authors.forename: Darina B
authors.initials: DB
authors.lastname: Dimitrova
authors.forename: Blagovesta T
authors.initials: BT
authors.lastname: Gocheva
authors.forename: Mariana D
authors.initials: MD
authors.lastname: Palamareva
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002264:Carboxylic Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006835:Hydrazones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology; D015363:Quinolones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002264:Carboxylic Acids; D003374:Coumarins; D006835:Hydrazones; D015363:Quinolones; C030123:coumarin; D010400:Penicillin G