title: Design of organocatalysts for asymmetric direct syn-aldol reactions.
abstract: Two new organocatalysts 3a and 3b, derived from L-leucine and (S)-beta-amino alcohols that were prepared from L-valine, were designed and afforded the direct syn-aldol reactions of a wide scope of aldehydes with various ketones with an excellent diastereomeric ratio of up to >20/1 and enantioselectivities of up to 99% ee.
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Xu
authors.forename: Yan-Zhao
authors.initials: YZ
authors.lastname: Wang
authors.forename: Liu-Zhu
authors.initials: LZ
authors.lastname: Gong