Peroxisomal dynamics.
Peroxisomes are a dynamic compartment in almost all eukaryotic cells and have diverse metabolic roles in response to environmental changes and cellular demands. The accompanying changes in enzyme content or abundance of peroxisomes are accomplished by dynamically operating membrane- and matrix-protein transport machineries. This review discusses recent progress in understanding peroxisomal proliferation and maintenance, insertion of peroxisomal membrane proteins, compartmentalization of peroxisomal matrix proteins and selective degradation of peroxisomes via pexophagy.
Platta
Harald W
HW
Ruhr-Universität Bochum, Medizinische Fakultät, Institut für Physiologische Chemie, Abteilung für Systembiochemie, Universitätsstr. 150, D-44780 Bochum, Germany.
Erdmann
Ralf
R
D000818:Animals; D001343:Autophagy; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D020675:Peroxisomes / Q000378:metabolism*; D021382:Protein Sorting Signals; D021381:Protein Transport; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism
D016326:Extracellular Matrix Proteins; D008565:Membrane Proteins; D021382:Protein Sorting Signals; D025801:Ubiquitin; C085380:peroxisomal targeting sequence receptor