The Clinical Breast Care Project: an important resource in investigating environmental and genetic contributions to breast cancer in African American women.
Age at diagnosis, pathological characteristics, and tumor behavior differ between African American (AAW) and Caucasian women (CW) with breast cancer, with AAW having more aggressive tumors and higher mortality rates. Although both societal and molecular contributions to these disparities have been suggested, the African American population has traditionally been under-represented in research and clinical protocols, limiting the power of epidemiologic and molecular studies to provide better understanding of disease pathogenesis in this minority population. The Clinical Breast Care Project (CBCP) has developed a large tissue and blood repository from patients undergoing treatment for breast cancer, with previous history of breast cancer, counseled in the Risk Reduction Clinic, screened by routine mammography, or undergoing elective reductive mammoplasty. Recruitment of AAW into the CBCP was successful; 25% of the 2,454 female patients were African American, including 35% disease-free, 3% high-risk, 40% benign, 8% preinvasive and 14% with invasive breast disease. More than 500 data fields regarding lifestyle choices, socioeconomic status, health history and geography were collected from all participants, and all consenting individuals provided blood specimens for genomic and proteomic studies. Tissues were collected from all patients undergoing surgical procedures using protocols that preserve the macromolecules for downstream research applications. In addition, patients were followed after diagnosis, with >85% of patients providing ongoing and updated demographic and clinical information. Thus, recruitment efforts in the CBCP have resulted in collection of well-annotated information and research-quality specimens from a large number of AAW. This unique resource will allow for the identification of biological and environmental factors associated with the identification of genetic and non-genetic factors associated with the occurrence, detection, prognosis, or survival of breast cancer in AAW.
Ellsworth
Rachel E
RE
Clinical Breast Care Project, Windber Research Institute, Windber, PA 15963, USA. r.ellsworth@wriwindber.org
Zhu
Kangmin
K
Bronfman
Lee
L
Gutchell
Veronica
V
Hooke
Jeffrey A
JA
Shriver
Craig D
CD
D000328:Adult; D001741:Black or African American; D001771:Blood Banks; D001940:Breast; D001943:Breast Neoplasms / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics / Q000473:pathology; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008889:Military Personnel; D018579:Patient Selection; D014015:Tissue Banks; D014481:United States