title: Saponins from the roots of Nylandtia spinosa.
abstract: From the roots of Nylandtia spinosa, four new triterpene saponins, 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-galactopyranosyl-(1-->4)-[alpha- l-arabinopyranosyl-(1-->3)]-beta- d-xylopyranosyl-(1-->4)-[beta- d-apiofuranosyl-(1-->3)]-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester ( 1), 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-galactopyranosyl-(1-->4)-[alpha- l-arabinopyranosyl-(1-->3)]-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester ( 2), 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-apiofuranosyl-(1-->4)-[beta- d-galactopyranosyl-(1-->2)]-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester ( 3), and 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-apiofuranosyl-(1-->3)-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester ( 4), were isolated, together with the known tenuifolin. Their structures were established mainly by 2D NMR techniques and mass spectrometry. Compounds 1- 4 were evaluated for cytotoxicity against HCT 116 and HT-29 human colon cancer cells, but were inactive (IC50 > 5 microg/mL).
authors.affiliation: Laboratoire de Pharmacognosie, UMIB, UPRES-EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7, Boulevard Jeanne D'Arc, BP 87900, 21079 Dijon Cedex, France.
authors.forename: Cheikh
authors.initials: C
authors.lastname: Diome
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Mitaine-Offer
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Clément
authors.initials: C
authors.lastname: Delaude
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mirjolet
authors.forename: Olivier
authors.initials: O
authors.lastname: Duchamp
authors.forename: Marie-Aleth
authors.initials: MA
authors.lastname: Lacaille-Dubois
mesh_terms: D006801:Humans; D003373:Coumaric Acids; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D029608:Polygalaceae / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013095:Spermidine / Q000031:analogs & derivatives; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D003373:Coumaric Acids; C532650:keayanidine B; D012503:Saponins; D013095:Spermidine; D014315:Triterpenes; C407311:tenuifolic saponin