Development and organization of the human brain tissue compartments across the lifespan using diffusion tensor imaging.
We used a diffusion tensor imaging-based whole-brain tissue segmentation to characterize age-related changes in (a) whole-brain grey matter, white matter, and cerebrospinal fluid relative to intracranial volume and (b) the corresponding brain tissue microstructure using measures of diffusion tensor anisotropy and mean diffusivity. The sample, a healthy cohort of 119 right-handed males and females aged 7-68 years. Our results demonstrate that white matter and grey matter volumes and their corresponding diffusion tensor anisotropy and mean diffusivity follow nonlinear trajectories with advancing age. In contrast, cerebrospinal fluid volume increases linearly with age.
Hasan
Khader M
KM
Department of Diagnostic and Interventional Imaging, University of Texas-Houston Health Science Center, Houston, Texas, USA. Khader.M.Hasan@uth.tmc.edu
Sankar
Ambika
A
Halphen
Christopher
C
Kramer
Larry A
LA
Brandt
Michael E
ME
Juranek
Jenifer
J
Cirino
Paul T
PT
Fletcher
Jack M
JM
Papanicolaou
Andrew C
AC
Ewing-Cobbs
Linda
L
D000293:Adolescent; D041923:Adolescent Development / Q000502:physiology*; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D016880:Anisotropy; D001284:Atrophy / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development*; D001931:Brain Mapping / Q000379:methods*; D002552:Cerebral Ventricles / Q000033:anatomy & histology / Q000254:growth & development; D002648:Child; D002657:Child Development / Q000502:physiology*; D015331:Cohort Studies; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000502:physiology / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology / Q000502:physiology; D019581:Neuropil / Q000166:cytology / Q000502:physiology; D017711:Nonlinear Dynamics; D013346:Subarachnoid Space / Q000033:anatomy & histology / Q000254:growth & development