title: Discordant hemodynamic and fibrinolytic adaptations following a 6-week cardiac rehabilitation program.
abstract: The present study evaluated changes in hemodynamics and fibrinolysis during 6 weeks of participation in an exercise-based cardiac rehabilitation program. Fourteen patients trained for 3 days per week for 6 weeks using American College of Sports Medicine guidelines for intensity and duration. Blood samples were taken at baseline and after 3 and 6 weeks of participation and analyzed for tissue plasminogen activator (t-PA) activity and antigen, plasminogen activator inhibitor-1 (PAI-1) activity and antigen, and relative quantification of t-PA and PAI-1 RNA. Data were analyzed using repeated measures analysis of variance. Training elicited significant decreases in submaximal exercise heart rate and systolic blood pressure and resting systolic blood pressure (p<.05). There were no significant changes in plasma concentrations of t-PA or PAI-1, and no change was observed in t-PA or PAI-1 gene expression. The present findings suggest that favorable hemodynamic adaptations may occur after only 6 weeks of exercise-based cardiac rehabilitation, but longer training periods may be needed to elicit positive hemostatic adaptations.
authors.affiliation: Department of Kinesiology, Michigan State University, East Lansing, MI, USA. prnagelkirk@bsu.edu
authors.forename: Paul R
authors.initials: PR
authors.lastname: Nagelkirk
authors.forename: Barry A
authors.initials: BA
authors.lastname: Franklin
authors.forename: Adam M
authors.initials: AM
authors.lastname: Coughlin
authors.forename: Houria I
authors.initials: HI
authors.lastname: Hassouna
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Fink
authors.forename: James M
authors.initials: JM
authors.lastname: Pivarnik
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Womack
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000097:blood / Q000503:physiopathology / Q000534:rehabilitation*; D003430:Cross-Sectional Studies; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D016896:Treatment Outcome