title: Value of real-time 3-dimensional echocardiography sectional diagnosis in complex congenital heart disease evaluated by receiver operating characteristic analysis.
abstract: OBJECTIVE
  We sought to evaluate the value of real-time 3-dimensional (3D) echocardiography (RT-3DE) in the pathologic morphology of complex congenital heart disease (CHD) using receiver operating characteristic (ROC) analysis.
  
  
  METHODS
  Thirty patients with complex CHD were examined by 2-dimensional echocardiography (2DE) and RT-3DE. Their diagnoses of pathologic morphology were made by 3 echocardiographers blinded to clinical data. Their value was evaluated by ROC analysis using a 5-point categorical scale in major cardiovascular structures and spatial relationships among complex CHD.
  
  
  RESULTS
  Compared with surgical findings, there were 75.6% of the definitely correct in RT-3DE and 64.4% in 2DE. ROC curve for RT-3DE was located left-superior to that for 2DE, and the area under ROC curve for RT-3DE (A = 0.96) was higher than that for 2DE (A = 0.90). There was significant difference between them by the method of Z test (Z = 2.64, P = .0083).
  
  
  CONCLUSIONS
  With the spatial 3D display of cardiovascular structural malformations, RT-3DE, coupled with conventional Doppler 2DE, may add information on complex CHD.
authors.affiliation: Pediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
authors.forename: Guo-zhen
authors.initials: GZ
authors.lastname: Chen
authors.forename: Guo-ying
authors.initials: GY
authors.lastname: Huang
authors.forename: Zi-yu
authors.initials: ZY
authors.lastname: Tao
authors.forename: Xiao-qin
authors.initials: XQ
authors.lastname: Liu
authors.forename: Qi-shan
authors.initials: QS
authors.lastname: Lin
mesh_terms: D002648:Child; D002675:Child, Preschool; D003199:Computer Systems; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007223:Infant; D008297:Male; D015588:Observer Variation; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016037:Single-Blind Method