title: [Microsatellite DNA polymorphism of adrenomedullin gene and atherosclerotic cerebral infarction].
abstract: OBJECTIVE
  To detect the correlation between the microsatellite DNA polymorphism of adrenomedullin(ADM) gene (repeated sequences of CA) and the atherosclerotic cerebral infarction (ACI).
  
  
  METHODS
  With PCR, ADM genotype was monitored from 189 normotensive subjects and 283 cerebral infarction patients. By using radioimmunoassay, their plasma ADM concentration was measured, so as the biochemical index.
  
  
  RESULTS
  The genotype distribution of ADM between the health control and ACI groups was significantly different, chi square was 28.732, P < 0.05. As one of the four alleles, including 11, 13, 14 and 19 alleles, the frequency of 19 allele in ACI groups was much higher than that in the health control group, chi square was 26.929, P < 0.05. However, there was no significant difference in plasma ADM concentration among the different genotypes of the ACI patients.
  
  
  CONCLUSIONS
  Microsatellite DNA polymorphism of ADM gene may be associated with the genetic predisposition to ACI.
authors.affiliation: Department of Neurology, the Second Affiliated Hospital, China Medical University, Shenyang, Liaoning, 110004 PR China. biguorongcmu@sina.com
authors.forename: Guo-rong
authors.initials: GR
authors.lastname: Bi
authors.forename: Hong
authors.initials: H
authors.lastname: Hai
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Bai
authors.forename: He-min
authors.initials: HM
authors.lastname: Zhang
authors.forename: Hui-jie
authors.initials: HJ
authors.lastname: Zhou
mesh_terms: D053607:Adrenomedullin / Q000235:genetics*; D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D053607:Adrenomedullin