title: Malignant meningitis secondary to lung adenocarcinoma: an unusual relapse.
abstract: We describe a 64-year-old man with locally advanced lung adenocarcinoma who had meningeal relapse soon after the completion of intensive chemo-radiotherapy. Diagnosis of the malignant meningitis was established by cytological examination of the cerebrospinal fluid, which showed malignant cells consistent with adenocarcinoma from the primary site. Although very rare, it is possible that successful chemo-radiotherapy for locally advanced lung cancer could not prevent malignant meningitis as observed in our patient. Physicians should consider performance of brain MRI or contrast CT of the brain and a lumbar puncture to exclude the diagnosis of malignant meningitis, an uncommon but devastating complication of malignancy.
authors.affiliation: Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ano
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Satoh
authors.forename: Kensuke
authors.initials: K
authors.lastname: Nakazawa
authors.forename: Morio
authors.initials: M
authors.lastname: Ohtsuka
authors.forename: Youichi
authors.initials: Y
authors.lastname: Anami
authors.forename: Masayuki
authors.initials: M
authors.lastname: Noguchi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hizawa
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D018810:Magnetic Resonance Angiography; D008297:Male; D008581:Meningitis / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D014057:Tomography, X-Ray Computed