title: Electronegative electroretinogram associated with topiramate toxicity and vitelliform maculopathy.
abstract: Topiramate is known to cause ocular side effects such as refractive changes and angle closure. We describe a patient with an electronegative electroretinogram (ERG) which may have been related to topiramate use. Electronegative ERG's have been associated with other drugs in humans as well as topiramate use in rabbits. However, this would be the first suggestion of causality in humans.
authors.affiliation: Brown Glaucoma Laboratory at Edward S. Harkness Eye Institute, Columbia University, New York, NY 10032, USA. irena.tsui@gmail.com
authors.forename: Irena
authors.initials: I
authors.lastname: Tsui
authors.forename: Daniel
authors.initials: D
authors.lastname: Casper
authors.forename: Chai Lin
authors.initials: CL
authors.lastname: Chou
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Tsang
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004596:Electroretinography / Q000187:drug effects*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008268:Macular Degeneration / Q000139:chemically induced* / Q000175:diagnosis; D020190:Myoclonic Epilepsy, Juvenile / Q000188:drug therapy; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose