title: Translational control: a target for cancer therapy.
abstract: Cap-mediated translation is the default mechanism for the synthesis of proteins in eukaryotic cells. Increasingly, malignant cells have been found to have deregulation of this process. Return of normal translational control is associated with loss of tumorigenic potential in pre-clinical models. Currently, a variety of novel therapeutics are in development targeting this mechanism as a treatment for cancer.
authors.affiliation: The Division of Hematology-Oncology-Transplant, Department of Medicine, The University of Minnesota Medical School, Minneapolis, MN 55455, USA.
authors.forename: Saritha C
authors.initials: SC
authors.lastname: Thumma
authors.forename: Robert A
authors.initials: RA
authors.lastname: Kratzke
mesh_terms: D000818:Animals; D039561:Eukaryotic Initiation Factor-4E / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D010442:Peptide Chain Initiation, Translational; D014176:Protein Biosynthesis; D012315:RNA Caps
chemical_list: D039561:Eukaryotic Initiation Factor-4E; D012315:RNA Caps