title: Reproductive safety of vaccination with Vista 5 L5 SQ near breeding time as determined by the effect on conception rates.
abstract: Replacement heifers (N=799; 10 to 13 months of age) were vaccinated with Vista 5 L5 SQ (Intervet; a reconstituted vaccine-bacterin product containing modified-live cultures of infectious bovine rhinotracheitis [IBR] virus, bovine viral diarrhea virus [BVDV; types 1 and 2], parainfluenza-3 virus, and bovine respiratory syncytial virus and inactivated cultures of Leptospira serovars canicola, grippotyphosa, hardjo, icterohaemorrhagiae, and pomona with a proprietary adjuvant) at either 40 plus/minus 5 days (control; n=399) or 3 days (test; n=400) before peak breeding day. By 40 plus/minus 5 days before peak breeding day, heifers in both groups had greater average titers to IBR, BVDV types 1 and 2, and four of the five Leptospira antigens assessed as compared with prevaccination titers on day -90 plus/minus 25 days. Conception rates were not affected by treatment. This study suggests that conception rates will not differ between heifers vaccinated with Vista 5 L5 SQ 3 days before breeding and those vaccinated approximately 40 days before breeding.
authors.affiliation: Intervet, Inc., Millsboro, DE 19966, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Bolton
authors.forename: David
authors.initials: D
authors.lastname: Brister
authors.forename: Bill
authors.initials: B
authors.lastname: Burdett
authors.forename: Harold
authors.initials: H
authors.lastname: Newcomb
authors.forename: Scott
authors.initials: S
authors.lastname: Nordstrom
authors.forename: Bill
authors.initials: B
authors.lastname: Sanders
authors.forename: Tom
authors.initials: T
authors.lastname: Shelton
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D001947:Breeding / Q000379:methods*; D002417:Cattle / Q000276:immunology / Q000502:physiology*; D002418:Cattle Diseases / Q000517:prevention & control*; D030241:Diarrhea Virus 1, Bovine Viral / Q000276:immunology; D030242:Diarrhea Virus 2, Bovine Viral / Q000276:immunology; D005260:Female; D007919:Leptospira / Q000276:immunology; D029101:Parainfluenza Virus 3, Bovine / Q000276:immunology; D011247:Pregnancy; D018873:Pregnancy Rate; D018112:Respiratory Syncytial Virus, Bovine / Q000276:immunology; D012449:Safety; D013997:Time Factors; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary*