title: Restless legs syndrome: nonpharmacologic and pharmacologic treatments.
abstract: Treatment of restless legs syndrome (RLS) has as its goals alleviation of the primary symptoms of the disorder and establishment of normal sleep. Dopamine agonists are considered first-line treatment when daily treatment for primary RLS is indicated. Gabapentin and opioids may be of value for refractory cases. Initial treatment of secondary RLS should address the underlying cause.
authors.affiliation: Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Winkelman
authors.forename: Richard P
authors.initials: RP
authors.lastname: Allen
authors.forename: Penny
authors.initials: P
authors.lastname: Tenzer
authors.forename: Wayne
authors.initials: W
authors.lastname: Hening
mesh_terms: D000588:Amines / Q000008:administration & dosage / Q000627:therapeutic use; D018798:Anemia, Iron-Deficiency / Q000150:complications / Q000188:drug therapy; D000927:Anticonvulsants / Q000008:administration & dosage; D052160:Benzothiazoles / Q000008:administration & dosage / Q000378:metabolism; D002998:Clonazepam / Q000008:administration & dosage; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage / Q000627:therapeutic use; D015259:Dopamine Agents / Q000008:administration & dosage; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D005293:Ferritins / Q000097:blood; D000077206:Gabapentin; D006801:Humans; D007211:Indoles / Q000008:administration & dosage; D007501:Iron / Q000008:administration & dosage; D007980:Levodopa / Q000008:administration & dosage; D000077487:Pramipexole; D012148:Restless Legs Syndrome / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D014131:Trace Elements / Q000008:administration & dosage; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000588:Amines; D000927:Anticonvulsants; D052160:Benzothiazoles; D003509:Cyclohexanecarboxylic Acids; D015259:Dopamine Agents; D018491:Dopamine Agonists; D007211:Indoles; D014131:Trace Elements; C046649:ropinirole; D007980:Levodopa; D005680:gamma-Aminobutyric Acid; D002998:Clonazepam; D000077206:Gabapentin; D000077487:Pramipexole; D005293:Ferritins; D007501:Iron