Lance-Adams syndrome: a report of two cases.
Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have undergone a cardiorespiratory arrest, regained consciousness afterwards, and then developed myoclonus days or weeks after the event. Worldwide, 122 cases have been reported in the literature so far, including 1 case of Chinese. Here we report 2 Chinese LAS patients with detailed neuroimagings. Cranial single photon emission computed tomography (SPECT) of patient 1, a 52-year-old woman, showed a mild hypoperfusion in her left temporal lobe, whereas patient 2, a 54-year-old woman, manifested a mild bilateral decrease of glucose metabolism in the frontal lobes and a mild to moderate decrease of the N-acetyl aspartate (NAA) peak in the bilateral hippocampi by cranial [(18)F]-fluorodeoxyglucose positron emission tomographic (PET) scan and cranial magnetic resonance spectroscopy (MRS), respectively. We also review the literature on the neuroimaging, pathogenesis, and treatment of LAS.
Zhang
Yan-xing
YX
Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Liu
Jian-ren
JR
Jiang
Biao
B
Liu
Hui-qin
HQ
Ding
Mei-ping
MP
Song
Shui-jiang
SJ
Zhang
Bao-rong
BR
Zhang
Hong
H
Xu
Bin
B
Chen
Huai-hong
HH
Wang
Zhong-jin
ZJ
Huang
Jian-zheng
JZ
D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects*; D002524:Cerebellar Ataxia / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000209:etiology*; D008875:Middle Aged; D009207:Myoclonus / Q000175:diagnosis* / Q000209:etiology*; D013577:Syndrome