Effect of orally administered Eriobotrya japonica seed extract on allergic contact dermatitis in rats.
The anti-allergic activity of Eriobotrya japonica seeds extract (ESE) was investigated. Oral administration of ESE dramatically inhibited ear swelling due to allergic contact dermatitis caused by repeated application of two antigens, 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone) and dinitrofluorobenzene (DNFB), respectively. The increase of histamine content in inflamed ear tissue induced by oxazolone and DNFB was significantly antagonized by orally administered ESE. Eosinophil peroxidase and myeloperoxidase activity in both models was suppressed by orally administered ESE. Tumour necrosis factor-alpha in the inflamed region caused by repeated application of DNFB was also significantly suppressed. The findings suggest that ESE may be effective for treating allergic contact dermatitis.
Sun
Guangchen
G
Department of Biomedical Science, Kochi Medical Graduate School, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan. sungc2004@yahoo.com.cn
Zhang
Yixiu
Y
Takuma
Daisuke
D
Onogawa
Masahide
M
Yokota
Junko
J
Hamada
Atsuhide
A
Yoshioka
Saburo
S
Kusunose
Masahiko
M
Miyamura
Mitsuhiko
M
Kyotani
Shojiro
S
Nishioka
Yutaka
Y
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy*; D004139:Dinitrofluorobenzene; D047209:Eosinophil Peroxidase / Q000187:drug effects / Q000378:metabolism; D031983:Eriobotrya / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D008516:Medicine, Chinese Traditional; D010080:Oxazoles; D009195:Peroxidase / Q000187:drug effects / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
C119678:4-ethoxymethylene-2-phenyl-2-oxazoline-5-one; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D010080:Oxazoles; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D004139:Dinitrofluorobenzene; D047209:Eosinophil Peroxidase; D009195:Peroxidase