Activation of 1,1-difluoro-1-alkenes with a transition-metal complex: palladium(II)-catalyzed Friedel-Crafts-type cyclization of 4,4-(difluorohomoallyl)arenes.
Cationic palladium(II) ([Pd(MeCN)4](BF4)2) provides the first transition-metal-catalyzed method for electrophilic activation of electron-deficient 1,1-difluoro-1-alkenes, which allows their Friedel-Crafts-type cyclization with an intramolecular aryl group via a Wacker-type process. By using BF3.OEt2, the cyclization was effected by a catalytic amount of the palladium without its reoxidation.
Yokota
Misaki
M
Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan.
Fujita
Daishi
D
Ichikawa
Junji
J