title: Radical scavenging activity of Trianthema triquetra in male albino rats intoxicated with CCl4.
abstract: Radical scavenging activity of ethanolic extract of Trianthema triquetra root was investigated against CCl4 in rats. The rats were treated with T. triquetra (100 mg, 200 mg/kg b.w.) for a period of 7 days. Antihepatotoxic effect was studied by assaying the activities of thiobarbituric acid (TBARS), reduced glutathione (GSH), glutathione peroxidase (GPx),catalase (CAT), super oxide dismutase (SOD) and vitamin C (Vit. C). Lipid peroxidation is evidenced by an increase in the value of TBARS and also a distinct diminution in the level of GSH, Vit. C at 200 mg/kg b.w. The activity of antioxidant enzymes, such as GPx, CAT SOD and Vit. E is significantly recovered towards an almost normal level in animals coadministrated with T. triquetra. The maximum protection against CCl4 induced hepatic injury was afforded by the dose of 200 mg/kg b.w. of Trianthema triquetra.
authors.affiliation: P.G. Department of Biochemistry, S.T.E.T. Women's College, Mannargudi 614 001, India. Srianuman21@yahoo.co.in
authors.forename: M
authors.initials: M
authors.lastname: Chitra
authors.forename: K
authors.initials: K
authors.lastname: Nithyanandhi
mesh_terms: D035722:Aizoaceae / Q000737:chemistry*; D000818:Animals; D001205:Ascorbic Acid / Q000097:blood; D002251:Carbon Tetrachloride; D002374:Catalase / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D000431:Ethanol / Q000737:chemistry; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D005978:Glutathione / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000097:blood
chemical_list: D016166:Free Radical Scavengers; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D000431:Ethanol; D002251:Carbon Tetrachloride; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione; D001205:Ascorbic Acid