title: Treating nonalcoholic fatty liver disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) is a chronic illness with multiple consequences. The spectrum of disease ranges from simple steatosis, with benign prognosis, to a potentially progressive form, nonalcoholic steatohepatitis, which may lead to liver fibrosis and cirrhosis, leading to an increase in morbidity and mortality. Furthermore, hepatocellular carcinoma incidence in NAFLD is comparable with that observed in hepatitis C-infected patients once cirrhosis is established. Current therapy is limited to lifestyle changes and control of associated metabolic disorders; however, new treatments are on the way from basic research to bedside. A review of the current literature on treatment of nonalcoholic fatty liver disease is presented in this article.
authors.affiliation: Unidad de Hígado, Departamento de Investigación Biomédica, Fundación Clínica Médica Sur, México D.F., México. nmendez@medicasur.org.mx
authors.forename: Nahum
authors.initials: N
authors.lastname: Méndez-Sánchez
authors.forename: Marco
authors.initials: M
authors.lastname: Arrese
authors.forename: Daniel
authors.initials: D
authors.lastname: Zamora-Valdés
authors.forename: Misael
authors.initials: M
authors.lastname: Uribe
mesh_terms: D018450:Disease Progression; D005234:Fatty Liver / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007333:Insulin Resistance