A highly stereocontrolled total synthesis of dysiherbaine.
A total synthesis of dysiherbaine, a potent agonist of AMPA-KA type glutamate receptors, has been accomplished in completely stereocontrolled manner starting from tri-O-acetyl-D-galactal in 25 steps and in 3% overall yield.
Takahashi
Keisuke
K
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan.
Matsumura
Takashi
T
Ishihara
Jun
J
Hatakeyama
Susumi
S
D000409:Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D019086:Bridged Bicyclo Compounds, Heterocyclic; C121741:dysiherbaine; D000409:Alanine