title: [Preliminary study of the effect of HLA-Cw on haploidentical hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To investigate the effect of HLA-Cw on haploidentical hematopoietic stem cell transplantation (HHSCT) without T-cell depletion.
  
  
  METHODS
  HLA-Cw were detected with PCR-SSP, the clinical data of 21 cases of haploidentical hematopoietic stem cell transplantation, including 8 standard risk and 13 high risk cases from July 2002 to March 2006 were summarized, and the effect of HLA-Cw in HHSCT was analyzed.
  
  
  RESULTS
  Twenty patients achieved sustained, full-donor-type engraftment. The HLA-Cw matched and mismatched groups attained neutrophil recovery at a median of 12 days and 13 days, and platelet recovery to more than 20 x 10(9)/L at a median of 20 days and 23 days respectively (P > 0.05). The cumulative incidences of grades II-IV acute GVHD were 76.9% in HLA-Cw matched group and 14.3% in the mismatched group(P < 0.05). The incidences of chronic GVHD were 85.7% in HLA-Cw matched group and 57.1% in the mismatched group(P > 0.05). The 28 months disease-free survival probabilities were 49.0% in HLA-Cw matched group, and 85.7% in the mismatched group (P > 0.05). The Karnofsky score of survival patients was over 90%.
  
  
  CONCLUSIONS
  HLA-Cw mismatched in donor and recipient of HHSCT is beneficial for reducing II-IV aGVHD, and being in favor of long term survival.
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Suzhou University, Jiangsu Institute of Hematology, Suzhou 215006, China.
authors.forename: Ming-zhen
authors.initials: MZ
authors.lastname: Yang
authors.forename: De-pei
authors.initials: DP
authors.lastname: Wu
authors.forename: Hui-ying
authors.initials: HY
authors.lastname: Qiu
authors.forename: Xiao-wen
authors.initials: XW
authors.lastname: Tang
authors.forename: Miao
authors.initials: M
authors.lastname: Miao
authors.forename: Zheng-ming
authors.initials: ZM
authors.lastname: Jin
authors.forename: Xiao-jin
authors.initials: XJ
authors.lastname: Wu
authors.forename: Ai-ning
authors.initials: AN
authors.lastname: Sun
authors.forename: Wei-rong
authors.initials: WR
authors.lastname: Chang
authors.forename: Jun
authors.initials: J
authors.lastname: He
authors.forename: Wen-ying
authors.initials: WY
authors.lastname: Di
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000276:immunology; D015236:HLA-C Antigens / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D014184:Transplantation, Homologous / Q000276:immunology
chemical_list: D015236:HLA-C Antigens