[Use of Plaferon LB for cardiac preconditioning during experimental ischemia/reperfusion injury in rabbits].
The main goal of research was to study potential of Plaferon LB for cardiac preconditioning during experimental ischemia/reperfusion injury in rabbits. 30 rabbits (2.5-3.0 kg) were used in experiment. They were divided in 3 groups and 6 subgroups (n=5). In I group experimental design of m/i was performed by proximal ligation of left coronary artery (LCA) (2-6 hours). In II group on the 2 and 6 hour ligature was removed - reperfusion during 1 hour. In III group before ligation of LCA animals was administered Plaferon LB (0.2 mg/kg). The animals were under electrocardiographic monitoring. Troponin I was measured in blood. In II group after 1 hour of reperfusion Troponin I concentration was higher than in I group after 2 and 6 hours. In II group electrocardiographic data was worsened (rhythm and heart rate). In III group these changes were less marked. Obtained data confirm enhancement of myocardial injury during the reperfusion. Cardiac preconditioning by Plaferon LB significantly decreased pathologic indices.
Ubilava
T O
TO
Megreladze
I I
II
Dzhangavadze
M B
MB
Khodeli
N G
NG
Chkhaidze
Z A
ZA
D000818:Animals; D004195:Disease Models, Animal; D004562:Electrocardiography; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D009479:Neuropeptides / Q000627:therapeutic use*; D011817:Rabbits; D016896:Treatment Outcome
D009479:Neuropeptides; C091912:plaferon