title: Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6.
abstract: Instrumental conditioning allows animals to learn about the consequences of their own actions, but the underpinning molecular mechanisms remain elusive. Here we show that the sphingosine-1-phosphate (S1P) receptor Gpr6 is selectively expressed in the striatopallidal neurons in the striatum. Gpr6-deficient mice showed reduced striatal cyclic AMP production in vitro and selective alterations in instrumental conditioning in vivo. Thus, Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal.
authors.affiliation: Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California at Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095, USA.
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Lobo
authors.forename: Yijun
authors.initials: Y
authors.lastname: Cui
authors.forename: Sean B
authors.initials: SB
authors.lastname: Ostlund
authors.forename: Bernard W
authors.initials: BW
authors.lastname: Balleine
authors.forename: X William
authors.initials: XW
authors.lastname: Yang
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D005576:Colforsin / Q000494:pharmacology; D003216:Conditioning, Operant / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D005508:Food Deprivation; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D005917:Globus Pallidus / Q000166:cytology*; D049452:Green Fluorescent Proteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D011930:Reaction Time / Q000235:genetics; D049349:Receptors, Lysosphingolipid / Q000172:deficiency / Q000378:metabolism*
chemical_list: D049349:Receptors, Lysosphingolipid; D049452:Green Fluorescent Proteins; D005576:Colforsin; D000242:Cyclic AMP