title: High-risk benign breast lesions: current strategies in management.
abstract: BACKGROUND
  High-risk benign breast lesions can create confusion for both the patient and the clinician. This paper reviews the characteristics of these lesions to help direct appropriate management.
  
  
  METHODS
  The authors reviewed the literature regarding high-risk breast lesions and include management guidelines that we employ at our institute.
  
  
  RESULTS
  High-risk breast lesions offer varying degrees of increased risk for the future development of breast cancer. Chemoprevention may be used to help decrease the risks from some lesions.
  
  
  CONCLUSIONS
  The management of high-risk benign breast lesions can be confusing. Clinicians should assess the risk of future breast cancer and develop a proper screening and prevention strategy for each individual patient.
authors.affiliation: Comprehensive Breast Cancer Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. john.kiluk@moffitt.org
authors.forename: John V
authors.initials: JV
authors.lastname: Kiluk
authors.forename: Geza
authors.initials: G
authors.lastname: Acs
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Hoover
mesh_terms: D000465:Algorithms; D001706:Biopsy; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D003937:Diagnosis, Differential; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000473:pathology*; D018570:Risk Assessment
chemical_list: D004965:Estrogen Antagonists