title: Improvement and longterm maintenance of quality of life during treatment with adalimumab in severe rheumatoid arthritis.
abstract: OBJECTIVE
  In patients with longstanding severe rheumatoid arthritis (RA) receiving chronic treatment with adalimumab, health related quality of life (HRQOL) was assessed using new instruments [Functional Assessment of Chronic Illness Therapy-Fatigue scale (FACIT-Fatigue) and Health Utilities Index Mark 3 (HUI3)] and a more conventional instrument [Medical Outcomes Study Short Form-36 Health Survey (SF-36)].
  
  
  METHODS
  Different measures for collecting patient-reported outcomes were applied simultaneously during the 3-year study period. Sociodemographic and medical history data were assessed at the baseline visit. Clinical examinations (e.g., joint examination and morning stiffness), disease assessments, and HRQOL data were recorded every 8 weeks. For dichotomous and categorical variables, absolute and relative frequencies were calculated. Metric measures were described using mean and standard deviation and/or standard error of the mean. HRQOL data were analyzed using observed cases.
  
  
  RESULTS
  All assessed measures (FACIT-Fatigue, HUI3, SF-36) showed a rapid and statistically significant improvement from baseline following initiation of adalimumab therapy. This effect was maintained over the study period for a mean of 1.6 years in all applied measures. HRQOL data from all tested instruments were significantly correlated with each other.
  
  
  CONCLUSIONS
  Chronic therapy with adalimumab improved measures of fatigue and HRQOL in patients with longstanding RA.
authors.affiliation: Center for Health Economics, Leibniz University Hannover, Hannover; Abbott GmbH Co KG, Ludwigshafen, Germany. tm@ivbl.uni-hannover.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Mittendorf
authors.forename: Birgitta
authors.initials: B
authors.lastname: Dietz
authors.forename: Raimund
authors.initials: R
authors.lastname: Sterz
authors.forename: Hartmut
authors.initials: H
authors.lastname: Kupper
authors.forename: Mary A
authors.initials: MA
authors.lastname: Cifaldi
authors.forename: Johann-Matthias
authors.initials: JM
authors.lastname: von der Schulenburg
mesh_terms: D000068879:Adalimumab; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D005221:Fatigue / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D000068879:Adalimumab