title: Intramammary antibiotics in dairy goats: effect of stage of lactation, parity and milk volume on withdrawal periods, and the effect of treatment on milk compositional quality.
abstract: The length of the antibiotic withdrawal period after intramammary treatment was influenced by the milk yield of dairy goats during this trial. Shorter withdrawal periods were seen in relatively high yielding dairy goats (production above 1.5 l per day) compared to low producers (less than 1.3 l per day). High yielding goats treated with Curaclox LC (Norbrook [Pharmacia AH]) had a withdrawal period of 42 h, while low yielding goats, treated with the same product, had a withdrawal period of 74 h. The recommended withdrawal period for Curaclox LC for use in cattle is 72 h. Relatively high yielding goats treated with Rilexine 200 LC (Logos Agvet [Virbac]) had a significantly shorter withdrawal period (37 h) than that recommended for use in cattle (96 h). Low yielding goats treated with Spectrazol Milking Cow (Schering-Plough Animal Health) had a significantly longer (95 h) withdrawal period than that recommended for use in cattle (60 h). Withdrawal periods were also influenced by stage of lactation and parity. There was a moderate positive correlation between lactation number and withdrawal period, as measured by TRIS (R2 = 0.621), and a moderate negative correlation between stage of lactation and withdrawal period (R2 = -0.669). In Trials 1, 2 and 3 combined there was a moderate negative correlation between withdrawal period and volume (R2 = -0.511) and a strong positive correlation between withdrawal period and lactation number (R2 = 0.720). The differences in percentage milk fat, protein and lactose before, during and after treatment were not statistically significant except in Trial 3 (Curaclox LC and Rilexine 200 LC) where protein and lactose differed significantly. In Trial 2 (Spectrazol Milking Cow) milk fat percentages differed significantly between treatment and control groups as did protein percentages in Trial 3. These differences are however, not biologically meaningful.
authors.affiliation: Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa. jkarzis@mweb.co.za
authors.forename: J
authors.initials: J
authors.lastname: Karzis
authors.forename: E F
authors.initials: EF
authors.lastname: Donkin
authors.forename: I M
authors.initials: IM
authors.lastname: Petzer
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D003258:Consumer Behavior; D003257:Consumer Product Safety; D004350:Drug Residues / Q000032:analysis*; D004359:Drug Therapy, Combination; D005260:Female; D015511:Goat Diseases / Q000188:drug therapy* / Q000378:metabolism; D006041:Goats; D007774:Lactation / Q000378:metabolism; D008413:Mastitis / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D008892:Milk / Q000737:chemistry* / Q000166:cytology / Q000592:standards; D010298:Parity; D011247:Pregnancy
chemical_list: D000900:Anti-Bacterial Agents