title: Concise total synthesis of (-)-spongotine A.
abstract: The first asymmetric total synthesis of spongotine A is described. The oxidative synthesis of the imidazoline/ketone unit from keto aldehyde and diamine is a key step in this synthesis. The absolute stereochemistry of the asymmetric center of natural spongotine A is revealed as the (S)-configuration.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-Oka, Suita, Osaka, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Murai
authors.forename: Maiko
authors.initials: M
authors.lastname: Morishita
authors.forename: Ryo
authors.initials: R
authors.lastname: Nakatani
authors.forename: Ozora
authors.initials: O
authors.lastname: Kubo
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Fujioka
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kita
mesh_terms: D020650:Combinatorial Chemistry Techniques; D048288:Imidazolines / Q000138:chemical synthesis* / Q000737:chemistry; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D048288:Imidazolines; D026121:Indole Alkaloids; C525418:spongotine A