Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants.
OBJECTIVE
To report the incidence and management of elevated intraocular pressure (IOP) in patients with uveitis treated with the fluocinolone acetonide (FA) intravitreal implant.


METHODS
Pooled data from 3 multicenter, double-masked, randomized, controlled, phase 2b/3 clinical trials evaluating the safety and efficacy of the 0.59-mg or 2.1-mg FA intravitreal implant or standard therapy were analyzed.


RESULTS
During the 3-year follow-up, 71.0% of implanted eyes had an IOP increase of 10 mm Hg or more than baseline and 55.1%, 24.7%, and 6.2% of eyes reached an IOP of 30 mm Hg or more, 40 mm Hg or more, and 50 mm Hg or more, respectively. Topical IOP-lowering medication was administered in 74.8% of implanted eyes, and IOP-lowering surgeries, most of which were trabeculectomies (76.2%), were performed on 36.6% of implanted eyes. Intraocular pressure-lowering surgeries were considered a success (postoperative IOP of 6-21 mm Hg with or without additional IOP-lowering medication) in 85.1% of eyes at 1 year. The rate of hypotony (IOP </= 5 mm Hg) following IOP-lowering surgery (42.5%) was not different from that of implanted eyes not subjected to surgery (35.4%) (P = .09).


CONCLUSIONS
Elevated IOP is a significant complication with the FA intravitreal implant but may be controlled with medication and surgery.
Goldstein
Debra A
DA
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1905 W Taylor St, M/C 648, Chicago, IL 60612, USA. debrgold@yahoo.com
Godfrey
David G
DG
Hall
Anthony
A
Callanan
David G
DG
Jaffe
Glenn J
GJ
Pearson
P Andrew
PA
Usner
Dale W
DW
Comstock
Timothy L
TL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002648:Child; D004343:Drug Implants; D005260:Female; D005446:Fluocinolone Acetonide / Q000008:administration & dosage* / Q000009:adverse effects; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009798:Ocular Hypertension / Q000139:chemically induced* / Q000188:drug therapy / Q000601:surgery; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D014130:Trabeculectomy; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy*
D000959:Antihypertensive Agents; D004343:Drug Implants; D005938:Glucocorticoids; D005446:Fluocinolone Acetonide