title: Has peptic ulcer disease changed during the past ten years in Korea? A prospective multi-center study.
abstract: BACKGROUND
  The incidence of H. pylori-negative, idiopathic peptic ulcer disease (IPUD) seems to be increasing with the changing trends of PUD and H. pylori infection in some developed countries.
  
  
  OBJECTIVE
  To investigate the changing trend of PUD and the prevalence ofH. pylori infection during the last decade and the prevalence of IPUD in Korea.
  
  
  METHODS
  We prospectively evaluated H. pylori infection and the characteristics of PUD in 895 patients with newly diagnosed PUD from September 2004 to February 2005.
  
  
  RESULTS
  The H. pylori infection rate in PUD was 72.0% and the proportion of IPUD was 22.2%. The proportion of gastric ulcer (GU) has significantly increased (47.8% vs. 44.3%) and the proportion of duodenal ulcer (DU) has significantly decreased (38.9% vs. 44.9%) compared with ten years ago. The changing trend in the prevalence of H. pylori infection in GU and DU showed an increase in GU (66.1% vs. 73.1%, P = 0.014) and a decrease in DU (79.3% vs. 68.1%, P = 0.001).
  
  
  CONCLUSIONS
  Compared with our results of ten years ago, there has been a significant change in the distribution of PUD and in the prevalence of H. pylori infection in GU and DU. Patients with IPUD are not uncommon in Korea.
authors.affiliation: Department of Gastroenterology, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea.
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Jang
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Choi
authors.forename: Woon Geon
authors.initials: WG
authors.lastname: Shin
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Kim
authors.forename: Yong Woo
authors.initials: YW
authors.lastname: Chung
authors.forename: Kyoung Oh
authors.initials: KO
authors.lastname: Kim
authors.forename: Cheol Hee
authors.initials: CH
authors.lastname: Park
authors.forename: Il Hyun
authors.initials: IH
authors.lastname: Baek
authors.forename: Kwang Ho
authors.initials: KH
authors.lastname: Baik
authors.forename: Sea Hyub
authors.initials: SH
authors.lastname: Kae
authors.forename: Hak Yang
authors.initials: HY
authors.lastname: Kim
mesh_terms: D001706:Biopsy; D016009:Chi-Square Distribution; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000453:epidemiology* / Q000382:microbiology*; D015995:Prevalence; D011446:Prospective Studies; D018709:Statistics, Nonparametric