Targeting altered calcium physiology in the heart: translational approaches to excitation, contraction, and transcription.
Calcium (Ca) is essential for excitation-contraction coupling. At the same time, Ca is of pivotal importance as a second messenger in cardiac signal transduction, where it regulates cardiac growth and function by activation of kinases and phosphatases, ultimately driving transcriptional responses and feeding back on Ca handling proteins, a phenomenon termed excitation-transcription coupling. Cardiac Ca homeostasis thus needs to be maintained via a delicate interplay of proteins to allow physiological function and adaptation, whereas disturbed Ca-handling and Ca-dependent signaling are hallmarks of heart failure. In this review, we will discuss the most recent mechanistic findings in Ca-handling and Ca-signaling proteins in the development of cardiac pathology with a focus on translational aspects.
Seidler
Tim
T
Department of Cardiology and Pneumology, Heart Center Georg-August-University Göttingen, Göttingen, Germany.
Hasenfuss
Gerd
G
Maier
Lars S
LS
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000235:genetics / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism; D025461:Feedback, Physiological / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006801:Humans; D009200:Myocardial Contraction / Q000235:genetics / Q000502:physiology; D014176:Protein Biosynthesis / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology
D002135:Calcium-Binding Proteins; D002118:Calcium