title: Dynamic organization of the cell nucleus.
abstract: The dynamic organization of the cell nucleus into subcompartments with distinct biological activities represents an important regulatory layer for cell function. Recent studies provide new insights into the principles, by which nuclear organelles form. This process frequently occurs in a self-organizing manner leading to the assembly of stable but plastic structures from multiple relatively weak interaction forces. These can rearrange into different functional states in response to specific modifications of the constituting components or changes in the nuclear environment.
authors.affiliation: Deutsches Krebsforschungszentrum and BIOQUANT, Division of Genome Organization & Function, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. Karsten.Rippe@bioquant.uni-heidelberg.de
authors.forename: Karsten
authors.initials: K
authors.lastname: Rippe
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000502:physiology*; D002843:Chromatin / Q000378:metabolism; D002875:Chromosomes / Q000235:genetics / Q000378:metabolism; D020541:Coiled Bodies / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism
chemical_list: D002843:Chromatin; D009687:Nuclear Proteins