title: Analysis of Y-chromosomal SNP haplogroups and STR haplotypes in an Algerian population sample.
abstract: The distribution of Y-chromosomal single nucleotide polymorphism (SNP) haplogroups and short tandem repeat (STR) haplotypes was determined in a sample of 102 unrelated men of Arab origin from northwestern Algeria (Oran area). A total of nine different haplogroups were identified by a panel of 22 binary markers. The most common haplogroups observed in the Algerian population were E3b2 (45.1%) and J1 (22.5%). Y-STR typing by a 17-loci multiplex system allowed 93 haplotypes to be defined (88 were unique). Striking differences in the allele distribution and gene diversity of Y-STR markers between haplogroups could be found. In particular, intermediate alleles at locus DYS458 specifically characterized the haplotypes of individuals carrying haplogroup J1. All the intermediate alleles shared a common repeat sequence structure, supporting the hypothesis that the variant originated from a single mutational event.
authors.affiliation: Department of Anatomy, Pharmacology and Legal Medicine, University of Turin, Turin, Italy. carlo.robino@unito.it
authors.forename: C
authors.initials: C
authors.lastname: Robino
authors.forename: F
authors.initials: F
authors.lastname: Crobu
authors.forename: C
authors.initials: C
authors.lastname: Di Gaetano
authors.forename: A
authors.initials: A
authors.lastname: Bekada
authors.forename: S
authors.initials: S
authors.lastname: Benhamamouch
authors.forename: N
authors.initials: N
authors.lastname: Cerutti
authors.forename: A
authors.initials: A
authors.lastname: Piazza
authors.forename: S
authors.initials: S
authors.lastname: Inturri
authors.forename: C
authors.initials: C
authors.lastname: Torre
mesh_terms: D000462:Algeria; D018912:Arabs / Q000235:genetics; D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting; D005787:Gene Frequency; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D020080:Tandem Repeat Sequences