title: Stage I ovarian carcinoma: different clinical pathologic patterns.
abstract: OBJECTIVE
  To analyze clinicopathologic patterns of early ovarian carcinoma.
  
  
  METHODS
  Retrospective chart and histopathology review.
  
  
  METHODS
  Mount Sinai School of Medicine, New York and the Centre Jean Perrin, Clermont Ferrand, France.
  
  
  METHODS
  Seventy-six consecutive cases of Fédération Internationale de Gynécologie et d'Obstétrique stage I ovarian carcinoma.
  
  
  METHODS
  Surgical staging.
  
  
  METHODS
  Symptomatology, pathology, and histology analysis.
  
  
  RESULTS
  Twenty-two cases (29%) were serous papillary carcinomas and 54 were nonserous carcinomas (71%) (40 endometrioid, 10 clear cell, and 4 mixed endometrioid and clear cell carcinomas). Ninety-eight percent of ovarian endometriosis, 95% of endometrial carcinomas, and 83% of endometrial polyps and hyperplasias were associated with nonserous carcinomas. Most patients with serous papillary carcinoma presented with asymptomatic pelvic masses; patients with nonserous carcinomas presented with pelvic pain or abnormal vaginal bleeding with or without pelvic mass.
  
  
  CONCLUSIONS
  Over two thirds of stage I ovarian carcinomas were nonserous, and were diagnosed because of associated symptoms: pelvic pain with endometriosis and/or adnexal masses, or vaginal bleeding from endometrial pathology. Serous papillary carcinomas were often asymptomatic and diagnosed during follow-up evaluations in breast cancer patients. Stage I ovarian carcinoma has different clinical and pathologic patterns than advanced ovarian carcinoma. The risk of ovarian and endometrial malignancy should be taken into consideration during evaluation of patients with endometriosis and breast cancer histories.
authors.affiliation: The Mount Sinai School of Medicine, Department of Pathology, New York, NY 10029, USA.
authors.forename: Liane
authors.initials: L
authors.lastname: Deligdisch
authors.forename: Frédérique
authors.initials: F
authors.lastname: Pénault-Llorca
authors.forename: Peter
authors.initials: P
authors.lastname: Schlosshauer
authors.forename: Albert
authors.initials: A
authors.lastname: Altchek
authors.forename: Michele
authors.initials: M
authors.lastname: Peiretti
authors.forename: Farr
authors.initials: F
authors.lastname: Nezhat
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology; D018269:Carcinoma, Endometrioid / Q000473:pathology; D002291:Carcinoma, Papillary / Q000473:pathology; D018283:Cystadenocarcinoma, Papillary / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology*; D012189:Retrospective Studies