title: A comparison of dexmedetomidine and midazolam for sedation in third molar surgery.
abstract: This randomised, double-blind study compared dexmedetomidine and midazolam for intravenous sedation during third molar surgery under local anaesthesia. Sixty patients received either dexmedetomidine (up to 1 microg x kg(-1)) or midazolam (up to 5 mg), which was infused until the Ramsay Sedation Score was four or the maximum dose limit was reached. Intra-operative vital signs, postoperative pain scores and analgesic consumption, amnesia, and satisfaction scores for patients and surgeons, were recorded. Sedation was achieved by median (IQR (range)) doses of 47 microg (39-52 (25-76)) or 0.88 microg x kg(-1) (0.75-1.0 (0.6-1.0)) dexmedetomidine, and 3.6 mg (3.3-4.4 (1.9-5.0)) or 0.07 mg x kg(-1) (0.055-0.085 (0.017-0.12)) midazolam. Heart rate and blood pressure during surgery were lower in dexmedetomidine group. There was no significant difference in satisfaction or pain scores. Midazolam was associated with greater amnesia. Dexmedetomidine produces comparable sedation to midazolam.
authors.affiliation: Department of Anaesthesiology, University of Hong Kong, Room 424, Block K, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong. cheucw@hku.hk
authors.forename: C W
authors.initials: CW
authors.lastname: Cheung
authors.forename: C L A
authors.initials: CL
authors.lastname: Ying
authors.forename: W K
authors.initials: WK
authors.lastname: Chiu
authors.forename: G T C
authors.initials: GT
authors.lastname: Wong
authors.forename: K F J
authors.initials: KF
authors.lastname: Ng
authors.forename: M G
authors.initials: MG
authors.lastname: Irwin
mesh_terms: D000328:Adult; D000772:Anesthesia, Local / Q000379:methods; D001794:Blood Pressure / Q000187:drug effects; D016292:Procedural Sedation / Q000379:methods*; D020927:Dexmedetomidine; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008874:Midazolam; D008964:Molar, Third / Q000601:surgery*; D010149:Postoperative Pain; D017060:Patient Satisfaction; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D008874:Midazolam