Biomaterial strategies to reduce implant-associated infections.
Although the prophylaxis in controlling sterility within the operating room environment has been greatly improved, implant-associated infection is still one of the most serious complications in implant surgeries due to the existence of immune depression in the peri-implant area. The antibacterial ability of materials themselves logically becomes an important factor in preventing implant-associated infections. With the understanding of the pathogenesis of implant-associated infections, many approaches have been developed through providing an anti-adhesive surface, delivering antibacterial agents to disrupt cell-cell communication and preventing bacteria aggregation or biofilm formation, or killing bacteria directly (lysing the cell membrane). In this article, we review the current strategies in improving the antibacterial ability of materials to prevent implant infection and further present promising tactics in materials design and applications.
Qiu
Y
Y
Clemson-MUSC Bioengineering Program, Department of Bioengineering, Clemson University, Charleston, South Carolina, USA.
Zhang
N
N
An
Y H
YH
Wen
X
X
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control*; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D048271:Chitosan / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D006801:Humans; D017053:Infection Control; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000517:prevention & control*; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D048271:Chitosan