[Effects of synthetic fragments of defensins on aggregation and adhesion of epitheliolike cells].
Normal course of processes of regeneration and epitheliazation of damage tissues has been shown to be based on the capability of cells participating in these processes for selective adhesion. In the case of the complete or partial absence of this capability in the cells-participants of the wound healing process, the so-called non-healing wounds appear. In this connection, it remains actual to search for natural agents promoting healing of chronic non-healing wounds. In the present work, we studied effects of synthetic fragments of leukocytic antimicrobial peptides defensines--GER, FGER, and GERA--on aggregation and adhesion of epitheliolike cells of the CHO-K1 line. These peptides have been established to have aggregate-stimulating properties; besides, they enhance adhesion of the cells to the untreated plastic and inhibit fibronectinmediated cell adhesion. Possible pathways of regulation by peptides of processes of intercellular and cell-matrix interaction are discussed as well as ways of release of these compounds in an organism and their functional role in an organism.
Ivanonva
V P
VP
Kovaleva
Z V
ZV
Sorochinskaia
E I
EI
Anokhina
V V
VV
Krivchenko
A I
AI
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D016466:CHO Cells; D002448:Cell Adhesion / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D023082:Defensins / Q000138:chemical synthesis / Q000494:pharmacology*; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D000890:Anti-Infective Agents; D023082:Defensins; D010455:Peptides