title: The MnSOD Val9Ala polymorphism, dietary antioxidant intake, risk and survival in ovarian cancer (Australia).
abstract: OBJECTIVE
  We assessed the MnSOD Val9Ala polymorphism and its interaction with dietary antioxidant intake in ovarian cancer risk and survival.
  
  
  METHODS
  The MnSOD polymorphism was assessed in 543 ovarian cancer cases and 1130 controls. We used regression analysis to model the association between genotype and risk, case-only analyses to estimate risk modification by dietary variables, and proportional hazard models for survival analysis.
  
  
  RESULTS
  We found no association between this polymorphism and ovarian cancer risk or survival, nor was there evidence of any interaction with dietary antioxidant intake.
  
  
  CONCLUSIONS
  The Val9Ala MnSOD polymorphism does not influence ovarian cancer risk or survival.
authors.affiliation: Queensland Institute of Medical Research, Brisbane, P.O. Royal Brisbane Hospital, Herston, QLD 4029, Australia.
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Johnatty
authors.forename: Christina M
authors.initials: CM
authors.lastname: Nagle
authors.forename: Amanda B
authors.initials: AB
authors.lastname: Spurdle
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Chen
authors.forename: Penelope M
authors.initials: PM
authors.lastname: Webb
authors.forename: Georgia
authors.initials: G
authors.lastname: Chenevix-Trench
mesh_terms: D000328:Adult; D000409:Alanine / Q000235:genetics; D000975:Antioxidants / Q000008:administration & dosage*; D001315:Australia; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism; D014633:Valine / Q000235:genetics
chemical_list: D000975:Antioxidants; D013482:Superoxide Dismutase; D014633:Valine; D000409:Alanine