Tubulin delivery: polymerization chaperones for microtubule assembly?
A new paper by Slep and Vale in a recent issue of Molecular Cell provides structural clues as to how three different +TIP proteins interact with tubulin and suggests that +TIPs deliver oligomers of tubulin dimers to growing microtubule ends.
Cassimeris
Lynne
L
Department of Biological Sciences, 111 Research Drive, Lehigh University, Bethlehem, PA 18015, USA. lc07@lehigh.edu
D000818:Animals; D019281:Dimerization; D006801:Humans; D016547:Kinesins / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism*; D018832:Molecular Chaperones / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D014404:Tubulin / Q000378:metabolism*
D018832:Molecular Chaperones; D014404:Tubulin; D016547:Kinesins