Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions?
Recent findings suggest that mammalian cells can use small non-coding RNAs (ncRNA) to regulate physiological viral infections. Here, we comment on several lines of evidence that support this concept. We discuss how viruses may in turn protect, suppress, evade, modulate, or adapt to the host cell's ncRNA regulatory schema.
Yeung
Man Lung
ML
Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892-0460, USA. yeungm@mail.nih.gov
Benkirane
Monsef
M
Jeang
Kuan-Teh
KT
D000818:Animals; D015967:Gene Expression Regulation, Viral; D006801:Humans; D008322:Mammals; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000378:metabolism*
D035683:MicroRNAs