title: Catenins: playing both sides of the synapse.
abstract: Synapses of the central nervous system (CNS) are specialized cell-cell junctions that mediate intercellular signal transmission from one neuron to another. The directional nature of signal relay requires synaptic contacts to be morphologically asymmetric with distinct protein components, while changes in synaptic communication during neural network formation require synapses to be plastic. Synapse morphology and plasticity require a dynamic actin cytoskeleton. Classical cadherins, which are junctional proteins associated with the actin cytoskeleton, localize to synapses and regulate synaptic adhesion, stability and remodeling. The major intracellular components of cadherin junctions are the catenin proteins, and increasing evidence suggests that cadherin-catenin complexes modulate an array of synaptic processes. Here we review the role of catenins in regulating the development of pre- and postsynaptic compartments and function in synaptic plasticity, with particular focus on their role in regulating the actin cytoskeleton.
authors.affiliation: Department of Biological Sciences, Stanford University, Stanford, CA 94305, United States. adamkwi@stanford.edu
authors.forename: Adam V
authors.initials: AV
authors.lastname: Kwiatkowski
authors.forename: William I
authors.initials: WI
authors.lastname: Weis
authors.forename: W James
authors.initials: WJ
authors.lastname: Nelson
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D051177:Catenins / Q000378:metabolism*; D002450:Cell Communication / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000378:metabolism* / Q000648:ultrastructure; D013570:Synaptic Membranes / Q000378:metabolism / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D000199:Actins; D051177:Catenins