title: Intraarterial infusion chemotherapy and conformal radiotherapy for cancer of the mouth: prediction of the histological response to therapy with magnetic resonance imaging.
abstract: BACKGROUND
  Although intraarterial chemotherapy has been used to treat head and neck cancers, some cases have shown poor response. If we can predict the response to this therapy on MRI, individual treatment plans may be altered to the most appropriate form of treatment.
  
  
  OBJECTIVE
  To evaluate whether MRI can predict the histological response to preoperative chemoirradiation in patients with cancer of the mouth.
  
  
  METHODS
  This study comprised of 29 consecutive patients with 30 oral cancers. All patients underwent tumor resection after intraarterial infusion chemotherapy and conformal radiotherapy. We compared the margin of the tumor, the presence of bone invasion, tumor area, and volume on pre- and post-treatment MRI with histological responses.
  
  
  RESULTS
  Eighteen lesions showed an excellent response, nine exhibited a good response, and three a poor response. Only the tumor area on pretreatment T1-weighted images and the tumor area and volume on pretreatment enhanced T1-weighted images were significantly correlated with the histological response (P = 0.039, 0.008, and 0.016, respectively); smaller cancers showed better responses. The other factors were not significantly correlated with the histological responses.
  
  
  CONCLUSIONS
  MRI parameters, excluding initial tumor area and volume, were not predictive of the histological response of oral tumors to preoperative treatment.
authors.affiliation: Department of Diagnostic Radiology, Radiation Oncology, and Oral and Maxillofacial Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ishii
authors.forename: Y
authors.initials: Y
authors.lastname: Korogi
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: R
authors.initials: R
authors.lastname: Nishimura
authors.forename: R
authors.initials: R
authors.lastname: Murakami
authors.forename: I
authors.initials: I
authors.lastname: Ikushima
authors.forename: K
authors.initials: K
authors.lastname: Kawanaka
authors.forename: M
authors.initials: M
authors.lastname: Shinohara
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000628:therapy*; D011300:Preoperative Care; D018714:Radiotherapy, Adjuvant; D020266:Radiotherapy, Conformal
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin