title: Small hepatocellular carcinoma with peripheral enhancement: pathological correlation with dual phase images by helical CT.
abstract: BACKGROUND
  The peripheral enhancement of small hepatocellular carcinoma (SHCC) is a rare appearance in dual phase images by helical computed tomography (CT). This study discusses this phenomenon and its correlative histopathology.
  
  
  METHODS
  The helical CT dual phase appearance of peripheral enhancement in SHCC was analyzed in 21 cases (22 lesions). All lesions were confirmed as SHCC by histopathological examination.
  
  
  RESULTS
  In these 22 lesions, enhanced peripheral ring in 20 lesions was incomplete, the thickness of enhanced peripheral ring varied and mural node could be found in hepatic arterial phase; only 2 lesions had complete peripheral ring enhancement and ring of uniform thickness in hepatic arterial phase. The enhancement of some peripheral rings and mural nodes dropped to very low density in portal venous phase. The tumour cells were grade I in 3 lesions, II in 16, III in 2 and IV in 1. The vascular supply was more abundant at the border than in the centre of 15 lesions and the vascular supply was deficient in both centre and border of the remaining 7 lesions. In 3 lesions, the pseudocapsule showed in the border of the lesion. In 12 lesions, flecks of necrosis were found in the border and/or centre of the lesion.
  
  
  CONCLUSIONS
  The characteristic peripheral enhancement in helical CT dual phase images of small hepatocellular carcinoma correlates with different vascular supplies, fibrous capsule and necrosis of the lesion.
authors.affiliation: Department of Radiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Ke-Guo
authors.initials: KG
authors.lastname: Zheng
authors.forename: Jing-Xian
authors.initials: JX
authors.lastname: Shen
authors.forename: Gen-Shu
authors.initials: GS
authors.lastname: Wang
authors.forename: Da-Sheng
authors.initials: DS
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D036542:Tomography, Spiral Computed