title: [The role of mucoprotective drugs in a treatment and prevention for NSAID-induced gastric ulcer].
abstract: NSAIDs compromise gastroduodenal defense mechanism mediated by inhibiting cyclooxygenase and leading to leukocyte infiltration or neutrophil adherence, and cause gastric ulcers. There are a number of mucoprotective drugs in Japan, and they were often used for NSAIDs-induced ulcer treatment. In vitro or in vivo studies, some mucoprotective drugs have been shown to have anti-inflammatory action due to the inhibition of leukocyte infiltration, production of inflammatory cytokines. However, mucoprotective drugs were given a low priority in "the Japanese guideline for the management of gastric ulcer" edited in 2003. Therefore, mucoprotective drugs should be investigated in terms of effects on NSAIDs-induced gastric ulcer patients because there are a few reliable evidences for the treatment of NSAID-induced gastric ulcer in Japan.
authors.affiliation: Department of Gastroenterology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases.
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Okuyama
authors.forename: Kazunari
authors.initials: K
authors.lastname: Tominaga
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Shiba
authors.forename: Toshio
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Oshitani
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Higuchi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Arakawa
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal