Contrasting roles of IFN-gamma in murine models of autoimmune thyroid diseases.
Interferon-gamma (IFN-gamma), a prototypic proinflammatory cytokine produced by several different cell types, including the Th1 subset of CD4(+) T cells, plays an important role in inflammation and autoimmune diseases. This review focuses on the varied and often contrasting roles of IFN-gamma in three murine models of autoimmune thyroid disease, experimentally induced autoimmune thyroiditis, the model of iodine-induced spontaneous autoimmune thyroiditis in NOD.H-2h4 mice and several different murine models of Graves' disease.
Fang
Yujiang
Y
Department of Internal Medicine, University of Missouri, Columbia, Missouri, USA.
Yu
Shiguang
S
Braley-Mullen
Helen
H
D000818:Animals; D004195:Disease Models, Animal; D005355:Fibrosis; D006111:Graves Disease / Q000503:physiopathology*; D007371:Interferon-gamma / Q000502:physiology*; D051379:Mice; D013961:Thyroid Gland / Q000276:immunology / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000209:etiology / Q000503:physiopathology*
D007371:Interferon-gamma