title: Life style-related diseases of the digestive system: endocrine disruptors stimulate lipid accumulation in target cells related to metabolic syndrome.
abstract: Many reports indicated that endocrine disruptors (EDs) affect several hormonal functions in various living things. Here, we show the effect of EDs on lipid accumulation in target cells involved in the onset of metabolic syndrome. Treatment with nonylphenol and bisphenol A, typical EDs, stimulated the accumulation of triacylglycerol in differentiated adipocytes from 3T3-L1, preadipocytes, in time- and concentration-dependent manners. Up-regulation of gene expressions involved in lipid metabolism and metabolic syndrome were observed in adipocytes treated with EDs. Similarly, stimulatory effects of EDs were also observed on the human hepatoma cell line HuH-7. These observations indicate that exposure to EDs stimulates the lipid accumulation in target cells involved in the metabolic syndrome and may cause the dysfunction of those cells, resulting in induction of metabolic syndrome.
authors.affiliation: Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan. kwada@dent.osaka-u.ac.jp
authors.forename: Koichiro
authors.initials: K
authors.lastname: Wada
authors.forename: Hirotada
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Nishikawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Sakuma
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
authors.forename: Yohko
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kamisaki
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D045744:Cell Line, Tumor; D052244:Endocrine Disruptors / Q000633:toxicity*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D024821:Metabolic Syndrome / Q000209:etiology*; D051379:Mice; D014280:Triglycerides / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D052244:Endocrine Disruptors; D014280:Triglycerides