Differential activities of newer antifungal agents against Candida albicans and Candida parapsilosis biofilms.
The activities of voriconazole, posaconazole, caspofungin, and anidulafungin against Candida albicans and Candida parapsilosis biofilms were evaluated. In contrast to planktonic cells, the MICs for voriconazole and posaconazole for the biofilms of the two species were high (>or=256 and >64 mg/liter, respectively) but relatively low for the echinocandins caspofungin and anidulafungin (<or=1 and <or=2 mg/liter, respectively).
Katragkou
Aspasia
A
Laboratory of Infectious Diseases, Third Department of Pediatrics, Aristotle University, Hippokration Hospital, 54642 Thessaloniki, Greece.
Chatzimoschou
Athanasios
A
Simitsopoulou
Maria
M
Dalakiouridou
Maria
M
Diza-Mataftsi
Eudoxia
E
Tsantali
Chaido
C
Roilides
Emmanuel
E
D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D002175:Candida / Q000145:classification / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D054714:Echinocandins / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D001393:Azoles; D054714:Echinocandins