title: Effects of a cell adhesion molecule coating on the blasted surface of titanium implants on bone healing in the rabbit femur.
abstract: OBJECTIVE
  One strategy to improve implant osseointegration is to control the quality of the bone reaction at the implant-bone tissue interface using an implant coated with biologically active substances. The purpose of this study was to investigate the effect of a tetra-cell adhesion molecule (T-CAM) coating composed of 4 cell-adhesion molecules-an arginine-glycine-aspartic acid (RGD) sequence, a proline-histidine-serine-arginine-asparagine (PHSRN) sequence, a tyrosine-histidine sequence (YH), and a glutamic acid-proline-aspartic acid-isoleucine-methionine (EPDIM)-on the rough-surfaced titanium implant on peri-implant bone formation in the rabbit femur with poor local bone conditions and minimal primary stability.
  
  
  METHODS
  Seven T-CAM-coated (blasted/T-CAM) and uncoated (blasted) implants with a rough surface (hydroxyapatite-blasted; Ra = 1.8 microm) were placed in slightly oversized beds of the metaphyses of the right and left femurs of 7 New Zealand White rabbits with light tactile pressure, and minimal primary stability was obtained. To evaluate the effects of T-CAM coating on the peri-implant bone healing response, histomorphometric analysis was performed 8 weeks after surgery. The 2 groups were compared using the Student t test, with a significance level of P < .05.
  
  
  RESULTS
  Compared to uncoated blasted implants at 8 weeks of healing, the blasted/T-CAM implants showed a significantly greater amount of bone-implant contact (BIC; P < .01) and new bone formation in the zones 0 to 100 microm and 0 to 500 microm lateral to the implant surface (P < .05) in the medullary space.
  
  
  CONCLUSIONS
  The T-CAM coating on the rough-surfaced titanium implants significantly enhanced peri-implant bone formation in rabbit femurs with poor local bone condition.
authors.affiliation: Department of Periodontology, College of Dentistry, Kyungpook National University, Daegu, Korea.
authors.forename: Jin-Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Sang-Gu
authors.initials: SG
authors.lastname: Lee
authors.forename: Byung-Ju
authors.initials: BJ
authors.lastname: Choi
authors.forename: Jo-Young
authors.initials: JY
authors.lastname: Suh
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology; D001853:Bone Marrow / Q000473:pathology; D002113:Calcification, Physiologic / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry; D005269:Femur / Q000473:pathology*; D008297:Male; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology*; D011817:Rabbits; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D014945:Wound Healing / Q000502:physiology
chemical_list: D015815:Cell Adhesion Molecules; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D003764:Dental Materials; D017886:Durapatite; D014025:Titanium