title: The emerging role of pituitary tumour transforming gene (PTTG) in endocrine tumourigenesis.
abstract: It is now 10 years since PTTG was first cloned and isolated. Perhaps the major story of the intervening decade of work performed by numerous groups around the world is the sheer multifunctionality ascribed to this gene. PTTG has been implicated in mechanisms of gene transactivation, cell transformation, angiogenesis, metabolism, apoptosis, DNA repair, genetic instability and mitotic control, both in endocrine and non-endocrine settings. In the current review, we cast a critical eye over a decade of PTTG research within the field of endocrine neoplasia.
authors.affiliation: Institute of Biomedical Research, Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH, UK.
authors.forename: D S
authors.initials: DS
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Fong
authors.forename: M L
authors.initials: ML
authors.lastname: Read
authors.forename: C J
authors.initials: CJ
authors.lastname: McCabe
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D006801:Humans; D051379:Mice; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D010911:Pituitary Neoplasms / Q000235:genetics*; D051381:Rats; D064249:Securin
chemical_list: D009363:Neoplasm Proteins; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human