Role of chelates in treatment of cancer.
Chelates are used in cancer as cytotoxic agent, as radioactive agent in imaging studies and in radioimmunotherapy. Various chelates based on ruthenium, copper, zinc organocobalt, gold, platinum, palladium, cobalt, nickel and iron are reported as cytotoxic agent. Monoclonal antibodies labeled with radioactive metals such as yttrium-90, indium-111 and iodine-131 are used in radioimmunotherapy. This review is an attempt to compile the use of chelates as cytotoxic drugs and in radioimmunotherapy.
Tripathi
Laxmi
L
Department of Pharmaceutical Chemistry, SD College of Pharmacy and Vocational Studies, Muzaffarnagar, Uttar Pradesh, India. tripathilaxmi@rediffmail.com
Kumar
Praveen
P
Singhai
A K
AK
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D048708:Cell Growth Processes / Q000187:drug effects / Q000528:radiation effects; D002614:Chelating Agents / Q000627:therapeutic use; D015913:Chelation Therapy / Q000639:trends*; D003603:Cytotoxins / Q000627:therapeutic use; D004358:Drug Therapy / Q000639:trends*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D016499:Radioimmunotherapy / Q000639:trends*; D011868:Radioisotopes / Q000627:therapeutic use; D051381:Rats; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D002614:Chelating Agents; D003603:Cytotoxins; D011868:Radioisotopes