title: [Association of -63A/C polymorphism of glutathione S-transferase M3 gene with essential hypertension in Chinese population].
abstract: OBJECTIVE
  To investigate the distribution of -63A/C polymorphism of human glutathione S-transferase M3(GSTM3) gene in Chinese Han population and the association of -63A/C polymorphism with essential hypertension (EH).
  
  
  METHODS
  -63A/C polymorphism of GSTM3 gene was examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 234 patients with EH and 328 healthy controls. The genotypes were confirmed partially by DNA sequencing.
  
  
  RESULTS
  The distribution of GSTM3 -63A/C was in Hardy-Weinberg equilibrium. The CC genotype frequency in EH group (6%) was significantly higher than that in control group(1.8%) (P < 0.05). After adjustment for age, body mass index, and other risk factors, the CC genotype was independently associated with hypertension (OR=3.447, 95%CI: 1.19-7.63; P=0.04).
  
  
  CONCLUSIONS
  The GSTM3 -63A/C polymorphism was associated with EH in Chinese Han population, the C allele might be a risk factor for EH in Chinese Han nationality.
authors.affiliation: Department of Medical Genetics, China Medical University, Shenyang, Liaoning, 110001 PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Miao
authors.initials: M
authors.lastname: Li
authors.forename: Man-long
authors.initials: ML
authors.lastname: Qi
authors.forename: Xiao-liang
authors.initials: XL
authors.lastname: Liu
authors.forename: Ying-hui
authors.initials: YH
authors.lastname: Li
authors.forename: Ling-yu
authors.initials: LY
authors.lastname: Fu
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000473:pathology; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis
chemical_list: D007527:Isoenzymes; D005982:Glutathione Transferase; C416969:glutathione transferase M3-3