title: Inherited human IRAK-4 deficiency: an update.
abstract: Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.
authors.affiliation: Centre d'étude des déficits immunitaires, Hôpital Necker-Enfants Malades, 149 Rue de Sèvres, Paris, 75015, France, EU. picardc@necker.fr
authors.forename: Capucine
authors.initials: C
authors.lastname: Picard
authors.forename: Horst
authors.initials: H
authors.lastname: von Bernuth
authors.forename: Cheng-Lung
authors.initials: CL
authors.lastname: Ku
authors.forename: Kun
authors.initials: K
authors.lastname: Yang
authors.forename: Anne
authors.initials: A
authors.lastname: Puel
authors.forename: Jean-Laurent
authors.initials: JL
authors.lastname: Casanova
mesh_terms: D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000235:genetics*; D053592:Interleukin-1 Receptor-Associated Kinases / Q000172:deficiency* / Q000235:genetics; D011008:Pneumococcal Infections / Q000276:immunology*; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus; D013296:Streptococcus pneumoniae
chemical_list: D053592:Interleukin-1 Receptor-Associated Kinases