title: Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue.
abstract: The myocardial tissue lacks significant intrinsic regenerative capability to replace the lost cells. Therefore, the heart is a major target of research within the field of tissue engineering, which aims to replace infarcted myocardium and enhance cardiac function. The primary objective of this work was to develop a biocompatible, degradable and superelastic heart patch from poly(glycerol sebacate) (PGS). PGS was synthesised at 110, 120 and 130 degrees C by polycondensation of glycerol and sebacic acid with a mole ratio of 1:1. The investigation was focused on the mechanical and biodegrading behaviours of the developed PGS. PGS materials synthesised at 110, 120 and 130 degrees C have Young's moduli of 0.056, 0.22 and 1.2 MPa, respectively, which satisfy the mechanical requirements on the materials applied for the heart patch and 3D myocardial tissue engineering construction. Degradation assessment in phosphate buffered saline and Knockout DMEM culture medium has demonstrated that the PGS has a wide range of degradability, from being degradable in a couple of weeks to being nearly inert. The matching of physical characteristics to those of the heart, the ability to fine tune degradation rates in biologically relevant media and initial data showing biocompatibility indicate that this material has promise for cardiac tissue engineering applications.
authors.affiliation: Department of Materials, Imperial College London, Prince Consort Road, London, UK. qizhi.chen@imperial.ac.uk
authors.forename: Qi-Zhi
authors.initials: QZ
authors.lastname: Chen
authors.forename: Alexander
authors.initials: A
authors.lastname: Bismarck
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hansen
authors.forename: Sarah
authors.initials: S
authors.lastname: Junaid
authors.forename: Michael Q
authors.initials: MQ
authors.lastname: Tran
authors.forename: Siân E
authors.initials: SE
authors.lastname: Harding
authors.forename: Nadire N
authors.initials: NN
authors.lastname: Ali
authors.forename: Aldo R
authors.initials: AR
authors.lastname: Boccaccini
mesh_terms: D003432:Cross-Linking Reagents / Q000737:chemistry; D003651:Decanoates / Q000138:chemical synthesis / Q000737:chemistry*; D020724:Elastomers / Q000737:chemistry*; D005663:Furans / Q000737:chemistry; D005990:Glycerol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D009206:Myocardium; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013314:Stress, Mechanical; D013718:Tensile Strength; D023822:Tissue Engineering; D014961:X-Ray Diffraction
chemical_list: D003432:Cross-Linking Reagents; D003651:Decanoates; D020724:Elastomers; D005663:Furans; D011108:Polymers; C469892:poly(glycerol-sebacate); C018674:tetrahydrofuran; D005990:Glycerol