Molecular basis for the regenerative properties of a secretion of the mollusk Cryptomphalus aspersa.
A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antioxidant SOD and GST activities. In addition, SCA stimulated fibroblast proliferation and rearrangement of the actin cytoskeleton. Additional mechanisms involved in the regenerative effect of SCA included the stimulation of extracellular matrix assembly and the regulation of metalloproteinase activities. Together, these effects provide an array of molecular mechanisms underlying SCA-induced cellular regeneration and postulate its use in regeneration of wounded tissue.
Brieva
A
A
R&D Department, IFC SA, Madrid, Spain.
Philips
N
N
Tejedor
R
R
Guerrero
A
A
Pivel
J P
JP
Alonso-Lebrero
J L
JL
Gonzalez
S
S
D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000502:physiology*; D016466:CHO Cells; D049109:Cell Proliferation; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003599:Cytoskeleton / Q000378:metabolism; D015536:Down-Regulation / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis; D061965:Matrix Metalloproteinase Inhibitors; D012038:Regeneration / Q000502:physiology*; D012908:Snails / Q000737:chemistry* / Q000502:physiology*
D000975:Antioxidants; D061965:Matrix Metalloproteinase Inhibitors; D020778:Matrix Metalloproteinase 2; D020781:Matrix Metalloproteinase 1