N-trans-feruloyltyramine as a melanin biosynthesis inhibitor.
In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.
Efdi
Mai
M
Department of Chemistry, Faculty of Engineering, Gifu University, Japan.
Ohguchi
Kenji
K
Akao
Yukihiro
Y
Nozawa
Yoshinori
Y
Koketsu
Mamoru
M
Ishihara
Hideharu
H
D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003373:Coumaric Acids / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D051379:Mice; D014442:Monophenol Monooxygenase / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D014439:Tyramine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
D003373:Coumaric Acids; D008543:Melanins; D010936:Plant Extracts; C074004:feruloyltyramine; D014442:Monophenol Monooxygenase; D014439:Tyramine