Oxygen-sensitive 3He-MRI in bronchiolitis obliterans after lung transplantation.
Oxygen-sensitive 3He-MRI was studied for the detection of differences in intrapulmonary oxygen partial pressure (pO2) between patients with normal lung transplants and those with bronchiolitis obliterans syndrome (BOS). Using software developed in-house, oxygen-sensitive 3He-MRI datasets from patients with normal lung grafts (n = 8) and with BOS (n = 6) were evaluated quantitatively. Datasets were acqiured on a 1.5-T system using a spoiled gradient echo pulse sequence. Underlying diseases were pulmonary emphysema (n = 10 datasets) and fibrosis (n = 4). BOS status was verified by pulmonary function tests. Additionally, 3He-MRI was assessed blindedly for ventilation defects. Median intrapulmonary pO2 in patients with normal lung grafts was 146 mbar compared with 108 mbar in patients with BOS. Homogeneity of pO2 distribution was greater in normal grafts (standard deviation pO2 34 versus 43 mbar). Median oxygen decrease rate during breath hold was higher in unaffected patients (-1.75 mbar/s versus -0.38 mbar/s). Normal grafts showed fewer ventilation defects (5% versus 28%, medians). Oxygen-sensitive 3He-MRI appears capable of demonstrating differences of intrapulmonary pO2 between normal lung grafts and grafts affected by BOS. Oxygen-sensitive 3He-MRI may add helpful regional information to other diagnostic techniques for the assessment and follow-up of lung transplant recipients.
Gast
Klaus Kurt
KK
Klinik und Poliklinik für diagnostische und interventionelle Radiologie, Klinikum der Johannes Gutenberg-Universität, Langenbeckstrasse 1, 55131 Mainz, Germany. kgast@radiologie.klinik.uni-mainz.de
Biedermann
Alexander
A
Herweling
Annette
A
Schreiber
Wolfgang Günter
WG
Schmiedeskamp
Jörg
J
Mayer
Eckhard
E
Heussel
Claus Peter
CP
Markstaller
Klaus
K
Kauczor
Hans-Ulrich
HU
Eberle
Balthasar
B
D000328:Adult; D001989:Bronchiolitis Obliterans / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006371:Helium; D006801:Humans; D016040:Lung Transplantation; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis*; D010313:Partial Pressure; D012189:Retrospective Studies
D006371:Helium; D010100:Oxygen