CSF IgH gene rearrangement analysis in isolated post-transplant lymphoproliferative disorder of the central nervous system.
Isolated post-transplant lymphoproliferative disorder (PTLD) of the central nervous system is rare and its diagnosis can be challenging. A biopsy is usually required in order to distinguish the disease from opportunistic infections. We present a case in whom immunoglobulin heavy chain gene rearrangement analysis of cerebrospinal fluid (CSF) was instrumental in establishing the diagnosis.
Baehring
Joachim M
JM
Department of Neurology and Neurosurgery, Yale University School of Medicine, 333 Cedar Street, TMP412, New Haven, CT 06510, USA. Joachim.baehring@yale.edu
Landry
Marie-Louise
ML
Cooper
Dennis
D
Hui
Pei
P
Bannykh
Serguei
S
D000368:Aged; D018951:Antigens, CD20 / Q000378:metabolism; D002490:Central Nervous System / Q000473:pathology*; D005260:Female; D015321:Gene Rearrangement / Q000502:physiology*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000134:cerebrospinal fluid*; D016030:Kidney Transplantation / Q000009:adverse effects; D008232:Lymphoproliferative Disorders / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000276:immunology* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods
D018951:Antigens, CD20; D007143:Immunoglobulin Heavy Chains