Effect of a probiotics supplementation on respiratory infections and immune and hormonal parameters during intense military training.
This study examined the effect of a probiotics supplementation on respiratory tract infection (RTI) and immune and hormonal changes during the French Commando training (3-week training followed by a 5-day combat course). Cadets (21 +/- 0.4 years) received either a probiotics (n = 24) or a placebo (n = 23) supplementation over the training period. We found no difference in the RTI incidence between groups but a significantly greater proportion of rhinopharyngitis in the probiotic group (p < 0.05). Among immune parameters, the major finding was an immunoglobulin A decrease after the combat course only in the placebo group (p < 0.01), but the difference between the two groups was not significant. A greater increase in dehydroepiandrostane sulfate was observed in the probiotics group after the combat course (p < 0.05). This study suggested that the benefits of a probiotics supplementation in a multistressor environment relied mainly on its capacity to prevent the infection to spread throughout the respiratory tract.
Tiollier
Eve
E
IMASSA, Département Physiologie, BP 73, 91223 Brétigny-sur-Orge, France.
Chennaoui
Mounir
M
Gomez-Merino
Danielle
D
Drogou
Catherine
C
Filaire
Edith
E
Guezennec
Charles Yannick
CY
D000284:Administration, Oral; D000328:Adult; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D006728:Hormones / Q000097:blood*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007070:Immunoglobulin A / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008889:Military Personnel / Q000193:education*; D019936:Probiotics / Q000008:administration & dosage / Q000627:therapeutic use*; D012141:Respiratory Tract Infections / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D012463:Saliva / Q000378:metabolism; D016896:Treatment Outcome
D006728:Hormones; D007070:Immunoglobulin A