title: Development and pathology of Echinostoma caproni in experimentally infected mice.
abstract: In the present article, several parasitological features of mice, each experimentally infected with 75 metacercariae of Echinostoma caproni (Trematoda: Echinostomatidae), were studied during the first 12 wk postinfection. Moreover, the early pathological responses also were analyzed and compared with data previously published on other host species of E. caproni to gain further insight into the factors determining worm rejection or establishment of chronic infections. The results obtained show that the pattern of E. caproni infection in mice is consistent with a highly compatible host-parasite system. This combination is characterized by a high worm establishment, high egg output, and long survival of the worms. However, some differences with respect to other highly compatible hosts have been observed, particularly in relation to the survival of the adult worms. Histological studies suggest that the kinetics of goblet cells, mucosal neutrophils, and mononuclear inflammatory cells in the mesentery seem to be essential in determining the course of E. caproni infection in mice.
authors.affiliation: Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.
authors.forename: Carla
authors.initials: C
authors.lastname: Muñoz-Antoli
authors.forename: Javier
authors.initials: J
authors.lastname: Sotillo
authors.forename: Carlos
authors.initials: C
authors.lastname: Monteagudo
authors.forename: Bernard
authors.initials: B
authors.lastname: Fried
authors.forename: Antonio
authors.initials: A
authors.lastname: Marcilla
authors.forename: Rafael
authors.initials: R
authors.lastname: Toledo
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001700:Biomphalaria; D004449:Echinostoma / Q000254:growth & development* / Q000472:pathogenicity; D004451:Echinostomiasis / Q000469:parasitology* / Q000473:pathology; D020397:Goblet Cells / Q000502:physiology; D006790:Host-Parasite Interactions; D007413:Intestinal Mucosa / Q000166:cytology / Q000473:pathology; D007422:Intestines / Q000469:parasitology / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000502:physiology; D008297:Male; D008643:Mesentery / Q000166:cytology / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D009504:Neutrophils / Q000502:physiology; D011897:Random Allocation