title: A simple method for the preparation of PEG-6-mercaptopurine for oral administration.
abstract: A new and efficient method for the synthesis of PEG-6-mercaptopurine is described. The key feature of the proposed approach is the protection of the thiol group against metabolic inactivation. Preliminary in vivo and in vitro evaluations of the macromolecular prodrug have been carried out.
authors.affiliation: Department of Pharmaceutical Science, piazzale Europa 1, 34127 Trieste, Italy. zacchign@units.it
authors.forename: Marina
authors.initials: M
authors.lastname: Zacchigna
authors.forename: Francesca
authors.initials: F
authors.lastname: Cateni
authors.forename: Gabriella
authors.initials: G
authors.lastname: Di Luca
authors.forename: Sara
authors.initials: S
authors.lastname: Drioli
mesh_terms: D000284:Administration, Oral; D016503:Drug Delivery Systems; D006801:Humans; D015122:Mercaptopurine / Q000008:administration & dosage* / Q000097:blood / Q000138:chemical synthesis*; D011092:Polyethylene Glycols; D011355:Prodrugs / Q000008:administration & dosage / Q000138:chemical synthesis
chemical_list: D011355:Prodrugs; D011092:Polyethylene Glycols; D015122:Mercaptopurine