title: Primary malignant melanoma of the transverse colon: report of a case and review of the literature.
abstract: Gastrointestinal involvement by malignant melanoma is predominantly a metastatic phenomenon. Although primary malignant melanoma of the gastrointestinal tract has been documented in the esophagus, stomach, small bowel, and anorectum, the incidence of primary melanoma of the colon is rare and remains controversial in most cases. We present a case of solitary malignant melanoma of the transverse colon occurring in a 64-year-old African American male patient. Complete dermatologic and ophthalmologic examinations revealed no evidence of a cutaneous or an ocular primary lesion. Microscopic examination of the resection specimen revealed malignant melanoma, which was confirmed by immunohistochemical positivity for S100 and melan-A. We believe that this tumor represents a primary colonic malignant melanoma.
authors.affiliation: Department of Pathology, Yale University School of Medicine, 20 York Street, New Haven, CT 06520-8023, USA. barton.kenney@yale.edu
authors.forename: Barton
authors.initials: B
authors.lastname: Kenney
authors.forename: Jorge
authors.initials: J
authors.lastname: Dotto
authors.forename: Robert
authors.initials: R
authors.lastname: Homer
authors.forename: Nelofar
authors.initials: N
authors.lastname: Shafi
authors.forename: Larisa
authors.initials: L
authors.lastname: Davydova
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D003110:Colonic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D058965:MART-1 Antigen; D008297:Male; D008545:Melanoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D009363:Neoplasm Proteins; D009418:S100 Proteins