title: The porcine nuclear receptor co-repressor 1 (NCOR1) gene: chromosome location, expression profile, and polymorphism.
abstract: NCOR1 (nuclear receptor co-repressor1) encodes a protein that represses the expression of the targeted genes by promoting chromatin condensation and disabling access to the transcription machinery. So far, only a few NCOR1 EST sequences are available, and the chromosomal location of NCOR1 is unknown in the porcine genome. In this study, we have localized NCOR1 to the end of pig chromosome (SSC) 12 by a porcine radiation hybrid panel. The expression profile of NCOR1 was clarified using RNA from 18 tissues, and it is expressed ubiquitously in pigs. We did not identify any missense mutation in the exonic region encoding the first SANT domain of the NCOR1 protein, although we found six SNPs and two deletions in intron 12, and three SNPs and one deletion in intron 13, using DNA of 10 founder animals in a White Duroc x Erhualian intercross. These polymorphic markers can be integrated into a genome scan for identifying the QTL affecting economically important traits in pigs.
authors.affiliation: Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, P.R. China.
authors.forename: Kaixuan
authors.initials: K
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
authors.forename: Junwu
authors.initials: J
authors.lastname: Ma
authors.forename: Xueming
authors.initials: X
authors.lastname: Yan
authors.forename: Lusheng
authors.initials: L
authors.lastname: Huang
mesh_terms: D000818:Animals; D001483:Base Sequence / Q000235:genetics; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics* / Q000378:metabolism; D003433:Crosses, Genetic; D020224:Expressed Sequence Tags; D005786:Gene Expression Regulation / Q000502:physiology*; D016678:Genome / Q000235:genetics; D007438:Introns / Q000235:genetics; D009687:Nuclear Proteins / Q000096:biosynthesis / Q000235:genetics*; D056971:Nuclear Receptor Co-Repressor 1; D009928:Organ Specificity / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D017434:Protein Structure, Tertiary / Q000235:genetics; D012097:Repressor Proteins / Q000096:biosynthesis / Q000235:genetics*; D017384:Sequence Deletion; D013552:Swine / Q000235:genetics* / Q000378:metabolism
chemical_list: D009687:Nuclear Proteins; D056971:Nuclear Receptor Co-Repressor 1; D012097:Repressor Proteins