title: Stepwise progression from ground-glass opacity towards invasive adenocarcinoma: long-term follow-up of radiological findings.
abstract: The natural history of lung adenocarcinoma with ground-glass opacity (GGO) remains undetermined. We describe a lung adenocarcinoma in which GGO transformed through a scar-like lesion over the long term into a solid nodule of poorly differentiated adenocarcinoma. Whether poorly differentiated lung adenocarcinoma can evolve from GGO-type adenocarcinoma is an important issue that requires clarification.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan. h-souda@hospital.sasebo.nagasaki.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Soda
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Katsumi
authors.initials: K
authors.lastname: Nakatomi
authors.forename: Nanae
authors.initials: N
authors.lastname: Tomonaga
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nakano
authors.forename: Seiji
authors.initials: S
authors.lastname: Nagashima
authors.forename: Masanobu
authors.initials: M
authors.lastname: Anami
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tsukamoto
authors.forename: Sigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D000368:Aged; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D008297:Male; D016634:Radiosurgery; D014057:Tomography, X-Ray Computed