title: Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver.
abstract: Plasma high density lipoprotein (HDL)-cholesterol levels are inversely correlated with the incidence of cardiovascular diseases. HDL is mainly assembled in the liver through the ATP-binding cassette transporter (ABCA1) pathway. In humans, plasma HDL-cholesterol levels are positively correlated with plasma adiponectin (APN) concentrations. Recently, we reported that APN enhanced apolipoprotein A-I (apoA-I) secretion and ABCA1 expression in HepG2 cells. In the present study, we investigated HDL assembly in APN-knockout (KO) mice. The apoA-I protein levels in plasma and liver were reduced in APN-KO mice compared with wild-type-mice. The ABCA1 expression in liver was also decreased in APN-KO mice. APN deficiency might cause the impaired HDL assembly by decreasing ABCA1 expression and apoA-I synthesis in the liver.
authors.affiliation: Department of Cardiovascular Medicine, Osaka University, Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Oku
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Matsuura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Koseki
authors.forename: Jose C
authors.initials: JC
authors.lastname: Sandoval
authors.forename: Miyako
authors.initials: M
authors.lastname: Yuasa-Kawase
authors.forename: Kazumi
authors.initials: K
authors.lastname: Tsubakio-Yamamoto
authors.forename: Daisaku
authors.initials: D
authors.lastname: Masuda
authors.forename: Norikazu
authors.initials: N
authors.lastname: Maeda
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohama
authors.forename: Masato
authors.initials: M
authors.lastname: Ishigami
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishida
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Hirano
authors.forename: Shinji
authors.initials: S
authors.lastname: Kihara
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
authors.forename: Shizuya
authors.initials: S
authors.lastname: Yamashita
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D052242:Adiponectin / Q000235:genetics / Q000502:physiology*; D000818:Animals; D016632:Apolipoprotein A-I / Q000097:blood / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000097:blood / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000097:blood; D008099:Liver / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D052242:Adiponectin; D016632:Apolipoprotein A-I; D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL