title: [A case of Wegener's granulomatosis associated with the syndrome of inappropriate secretion of ADH].
abstract: A 68 year-old woman was admitted with fever, productive cough and sore throat. A chest radiograph and a chest computed tomography showed multiple nodules in both lungs. Thoracoscopic lung biopsy was performed. The specimens showed vasculitis and geographic basophilic necrosis with palisading histiocytes, giant cells, and neutrophils. Wegener's granulomatosis was diagnosed. On the 5th hospital day, the serum sodium level was 128 mEq/l. Since secretion of antidiuretic hormone had continued despite a low plasma osmolarity, we diagnosed the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and initiated oral prednisolone and cyclophosphamide. As a result, the symptoms and image findings were improved, and serum sodium level became normal. This case was considered to be SIADH secondary to Wegener's granulomatosis.
authors.affiliation: Department of Respiratory Medicine, Gunma University Medical School.
authors.forename: Zen
authors.initials: Z
authors.lastname: Isobe
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Suga
authors.forename: Shigeto
authors.initials: S
authors.lastname: Hamaguchi
authors.forename: Shouzaburou
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Kenichirou
authors.initials: K
authors.lastname: Hara
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Aoki
authors.forename: Nozomi
authors.initials: N
authors.lastname: Aoki
authors.forename: Kana
authors.initials: K
authors.lastname: Aoyagi
authors.forename: Manabu
authors.initials: M
authors.lastname: Ueno
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Maeno
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
mesh_terms: D000368:Aged; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000473:pathology; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology*