Vasodilatation of sulfur dioxide derivatives and signal transduction.
The vasodilatation of sulfur dioxide (SO(2)) derivatives on the rat thoracic aortic rings and its cell signal transduction pathway were studied. The levels of cAMP, cGMP, PGI(2), TXA(2) and activities of PKA and adenylyl cyclase (AC) in the rings exposed to SO(2) derivatives were determined. The results indicated that SO(2) derivatives could dose-dependently relax the isolated rat aorta rings with or without endothelium precontracted by NE, no difference was found between the rings with and without endothelium; Levels of cAMP, PGI(2), AC activity and PKA activity in the aortic rings were significantly increased by the derivatives in a dose-related way; No change of cGMP and TXA(2) levels in rings was observed; cAMP/cGMP and PGI(2)/TXA(2) ratios were increased significantly by the SO(2) derivatives. These results led to the conclusions that SO(2) derivatives might cause the endothelium-independent vasorelaxation effect, and the vasorelaxation was mediated in partly by the signal transduction pathway of PGI(2)-AC-cAMP-PKA.
Meng
Ziqiang
Z
Institute of Environmental Medicine and Toxicology, Shanxi University, Taiyuan 030006, China.
Li
Yi
Y
Li
Junling
J
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D013458:Sulfur Dioxide / Q000008:administration & dosage*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D013458:Sulfur Dioxide; D011464:Epoprostenol; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D000262:Adenylyl Cyclases