Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus.
Fibroplast growth factor (FGF-21) is a recently discovered metabolic regulator. Its pathophysiologic role in humans remains unknown. In this study, we have investigated whether or not plasma FGF-21 level was different in patients with type 2 diabetes mellitus (T2DM) and non-diabetic controls. We also assessed associations between plasma FGF-21 body composition and several metabolic parameters. Fasting FGF-21 levels were significantly increased in patients with T2DM compared with controls (1.82+/-0.65 VS. 1.53+/-0.60 microg/L, P<0.05). In T2DM patients, fasting plasma FGF-21 correlate negatively with fasting blood glucose ( R= -0.31, P<0.05). Multiple regression analysis showed that FBG, plasma insulin and HOMA (IS) were independent influencing plasma FGF-21 levels. The present work suggests a potential role for FGF-21 in the pathogenesis of insulin resistance and T2DM.
Chen
W-W
WW
Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Li
L
L
Yang
G-Y
GY
Li
K
K
Qi
X-Y
XY
Zhu
W
W
Tang
Y
Y
Liu
H
H
Boden
G
G
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005215:Fasting; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
D001786:Blood Glucose; D005346:Fibroblast Growth Factors; D006442:Glycated Hemoglobin; D007328:Insulin; D014280:Triglycerides; C414620:fibroblast growth factor 21