title: Can circulated lung cancer cells pass to the urine without apparent urine tract metastases? A single centre series.
abstract: Urine cytology has been a useful tool for the diagnosis of urinary tract malignancies. However, the presence of tumor cells in the urine sediment without an obvious urothelial metastatic deposit is a rare phenomenon and in patients with lung cancer has never been reported. We present five cases with metastatic lung cancer and positive urine cytology. The possible mechanisms underlining this phenomenon and its implications are discussed.
authors.affiliation: Department of Medical Oncology, Ioannina University Hospital, Niarxou Avenue, 45500 Ioannina, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kamposioras
authors.affiliation: Department of Medical Oncology, Ioannina University Hospital, Niarxou Avenue, 45500 Ioannina, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Pentheroudakis
authors.affiliation: Department of Pathology-Cytopathology, Ioannina University Hospital, Ioannina, Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Malamou-Mitsi
authors.affiliation: Department of Pathology-Cytopathology, Ioannina University Hospital, Ioannina, Greece.
authors.forename: Lina
authors.initials: L
authors.lastname: Pappa
authors.affiliation: Department of Pathology-Cytopathology, Ioannina University Hospital, Ioannina, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Bafa
authors.affiliation: Department of Medical Oncology, Ioannina University Hospital, Niarxou Avenue, 45500 Ioannina, Greece. Electronic address: npavlid@cc.uoi.gr.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Pavlidis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000652:urine; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D014556:Urine / Q000166:cytology*; D014571:Urologic Neoplasms / Q000556:secondary*