A new concise strategy for synthesis of dibenzo[b,f]thiepins and related fused symmetrical thiepin derivatives.
A new strategy for preparation of dibenzo[b,f]thiepins and related fused systems in good overall yields is described, featuring ortho-metalation of aromatic or heterocyclic aldehyde acetals followed by treatment with bis(phenylsulfonyl) sulfide for construction of the required bis(aryl)- or bis(heteroaryl) sulfide precursors, which were thereafter subjected to deacetalization, and finally McMurry coupling as the ring-forming step.
Shirani
Hamid
H
Unit for Organic Chemistry, Department of Biosciences and Nutrition, Karolinska Institute, Novum Research Park, SE-141 57, Huddinge, Sweden.
Janosik
Tomasz
T
D003988:Dibenzothiepins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D003988:Dibenzothiepins