Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia.
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia rarely occur concurrently. We report a case in which these disorders were associated with an occult large granular lymphocyte leukemia. The peripheral blood cytopenias improved after glucocorticoids and intravenous immunoglobulin were administered, and response was maintained with cyclosporine. Large granular lymphocyte leukemia should be suspected in the setting of unexplained bone marrow failure.
Lai
Dominic W
DW
VA Greater Los Angeles Health Care System, Los Angeles, CA 90095-1678, United States.
Loughran
Thomas P
TP
Maciejewski
Jaroslaw P
JP
Sasu
Sebastian
S
Song
Sophie X
SX
Epling-Burnette
P K
PK
Paquette
Ronald L
RL
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D005260:Female; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D011696:Purpura, Thrombocytopenic / Q000150:complications*; D011971:Receptors, Immunologic / Q000032:analysis; D012010:Red-Cell Aplasia, Pure / Q000150:complications*; D000071176:Signaling Lymphocytic Activation Molecule Family
D015703:Antigens, CD; C084093:CD244 protein, human; D011971:Receptors, Immunologic; D000071176:Signaling Lymphocytic Activation Molecule Family