title: Nitric oxide prodrugs: diazeniumdiolate anions of hindered secondary amines.
abstract: Nitric oxide prodrugs derived from hindered secondary amines were prepared. The decomposition patterns of these prodrugs indicate that alpha-methyl groups around the nitrogen bearing the diazeniumdiolate group prolong their half-life in aqueous buffer.
authors.affiliation: Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.
authors.forename: Harinath
authors.initials: H
authors.lastname: Chakrapani
authors.forename: Brett M
authors.initials: BM
authors.lastname: Showalter
authors.forename: Michael L
authors.initials: ML
authors.lastname: Citro
authors.forename: Larry K
authors.initials: LK
authors.lastname: Keefer
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Saavedra
mesh_terms: D000588:Amines / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry*
chemical_list: D000588:Amines; D001391:Azo Compounds; D011355:Prodrugs; C452539:diazeniumdiolate; D009569:Nitric Oxide