title: Bikaverin and fusaric acid from Fusarium oxysporum show antioomycete activity against Phytophthora infestans.
abstract: OBJECTIVE
  To isolate and identify antioomycete substances from Fusarium oxysporum EF119 against Phytophthora infestans and to investigate their antimicrobial activities against various plant pathogenic bacteria, oomycetes and true fungi.
  
  
  RESULTS
  Two antioomycete substances were isolated from liquid cultures of F. oxysporum EF119, which shows a potent disease control efficacy against tomato late blight caused by P. infestans. They were identified as bikaverin and fusaric acid by mass and nuclear magnetic resonance spectral analyses. They inhibited the mycelial growth of plant pathogenic oomycetes and fungi. Fusaric acid also effectively suppressed the cell growth of various plant pathogenic bacteria, but bikaverin was virtually inactive. Treatment with bikaverin at 300 microg ml(-1) suppressed the development of tomato late blight by 71%. Fusaric acid provided effective control against tomato late blight and wheat leaf rust over 67% at concentrations more than 100 microg ml(-1).
  
  
  CONCLUSIONS
  Both bikaverin and fusaric acid showed in vitro and in vivo antioomycete activity against P. infestans.
  
  
  CONCLUSIONS
  Fusarium oxysporum EF119 producing both bikaverin and fusaric acid may be used as a biocontrol agent against tomato late blight caused by P. infestans.
authors.affiliation: Bio-Control Research Team, Korea Research Institute of Chemical Technology, Yusong, Taejon, Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Son
authors.forename: H Y
authors.initials: HY
authors.lastname: Kim
authors.forename: G J
authors.initials: GJ
authors.lastname: Choi
authors.forename: H K
authors.initials: HK
authors.lastname: Lim
authors.forename: K S
authors.initials: KS
authors.lastname: Jang
authors.forename: S O
authors.initials: SO
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: N D
authors.initials: ND
authors.lastname: Sung
authors.forename: J-C
authors.initials: JC
authors.lastname: Kim
mesh_terms: D002212:Capsicum / Q000382:microbiology; D005516:Food Microbiology; D005659:Fungicides, Industrial / Q000494:pharmacology*; D005669:Fusaric Acid / Q000737:chemistry / Q000494:pharmacology*; D005670:Fusarium / Q000737:chemistry*; D010838:Phytophthora / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D044004:Xanthones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D005659:Fungicides, Industrial; D010936:Plant Extracts; D044004:Xanthones; C000269:bikaverin; D005669:Fusaric Acid