Tissue factor: a critical role in inflammation and cancer.
A series of coordinated enzymatic reactions takes place in the body whenever blood clots. The major physiological initiator of these reactions is a membrane-bound glycoprotein known as tissue factor (TF), which is normally separated from the bloodstream by the vascular endothelium. Bleeding, caused by injury or tissue damage, activates a complex enzyme cascade as TF becomes exposed to the bloodstream. In disease states, leukocytes or the vascular endothelium may abnormally express TF to cause intravascular coagulation. The blood-coagulation cascade is also relevant to diseases such as hemophilia, in which patients are deficient in blood proteins necessary for clotting, and is linked to vascular diseases such as heart attack and stroke, in which clotting can lead to the occlusion of blood vessels. Coagulation is also activated in inflammation and cancer. In this article, we discuss characteristics of TF and review its role in inflammation and cancer.
Lwaleed
Bashir A
BA
Continence Technology and Skin Health Group, School of Nursing and Midwifery, University of Southampton, Southampton, United Kingdom. bashir@soton.ac.uk
Cooper
Alan J
AJ
Voegeli
David
D
Getliffe
Kathryn
K
D015415:Biomarkers; D001777:Blood Coagulation / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D013925:Thromboplastin / Q000276:immunology* / Q000378:metabolism
D015415:Biomarkers; D013925:Thromboplastin