title: Surgical guided tissue regeneration treatment of advanced periodontal defects: a 5-year follow-up study.
abstract: OBJECTIVE
  To study the 5-year outcome of combined use of guided tissue regeneration (GTR) barriers and bovine bone in advanced periodontal defects.
  
  
  METHODS
  In each of 24 patients, one defect was surgically exposed, debrided, filled with bovine bone, and covered with a bioresorbable barrier. Re-examinations were made after 1, 3, and 5 years.
  
  
  RESULTS
  Average full-mouth plaque scores (FMPS) were 14.5% at baseline and 10.7%, 9.8%, and 18.9% after 1, 3, and 5 years, respectively. Mean probing pocket depth (PPD) was 10.0 mm at baseline. Mean PPD reduction was 5.2 mm after 1 year, 5.6 mm after 3 years, and 5.3 mm after 5 years. Mean gingival recession was 1.0 mm after 1 year, 1.6 mm after 3 years, and 1.3 mm after 5 years. Mean gain in clinical attachment level (CAL) was 4.2 mm at the 1-year, 4.1 mm at the 3-year, and 4.3 mm at the 5-year examination. Smoking significantly influenced CAL change at all re-examinations. FMPS were significantly correlated with radiographic defect depth at the 5-year examination and CAL with smoking and FMPS at the 3-year examination.
  
  
  CONCLUSIONS
  Advanced periodontal defects can be successfully treated with the combined use of GTR barriers and bovine bone to substantially reduce PPD and achieve a stable, long-term gain of CAL.
authors.affiliation: Department of Periodontology, The Institute for Postgraduate Dental Education, Jönköping, Sweden. christer.slotte@lj.se
authors.forename: Christer
authors.initials: C
authors.lastname: Slotte
authors.forename: Barbro
authors.initials: B
authors.lastname: Asklöw
authors.forename: Dan
authors.initials: D
authors.lastname: Lundgren
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D004812:Epidemiologic Methods; D005260:Female; D005889:Gingival Recession / Q000000981:diagnostic imaging / Q000453:epidemiology; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000000981:diagnostic imaging / Q000453:epidemiology; D010510:Periodontal Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D010514:Periodontal Pocket / Q000000981:diagnostic imaging / Q000453:epidemiology; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D008567:Membranes, Artificial