title: Novel synthetic ligands for targeted PET imaging and radiotherapy of copper.
abstract: Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA-Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with (64)Cu, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA-Bn form stable complexes with (64)Cu.
authors.affiliation: Chemistry Division, Biological, Chemical, and Physical Science Department, Illinois Institute of Technology, 3101 S. Dearborn Street, Chicago, IL 60616, USA. Chong@iit.edu
authors.forename: Hyun-Soon
authors.initials: HS
authors.lastname: Chong
authors.forename: Santosh
authors.initials: S
authors.lastname: Mhaske
authors.forename: Mai
authors.initials: M
authors.lastname: Lin
authors.forename: Sankar
authors.initials: S
authors.lastname: Bhuniya
authors.forename: Hyun A
authors.initials: HA
authors.lastname: Song
authors.forename: Martin W
authors.initials: MW
authors.lastname: Brechbiel
authors.forename: Xiankai
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D003301:Copper Radioisotopes / Q000737:chemistry*; D004355:Drug Stability; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods*; D011878:Radiotherapy; D051381:Rats; D044967:Serum / Q000737:chemistry
chemical_list: D003301:Copper Radioisotopes; D008024:Ligands; D009942:Organometallic Compounds