title: Asymmetric distribution of visual evoked potentials in patients with migraine with aura during the interictal phase.
abstract: OBJECTIVE
  One of the most commonly described electrocortical phenomena in patients with migraine is an increased interhemispheric asymmetry, in response to different sensory stimuli. This study aims to evaluate the bioelectrical activity of both occipital cortices in patients with migraine with visual aura (MA) during the interictal period, and its possible relationship with visual symptoms.
  
  
  METHODS
  The authors recorded visual evoked potentials (VEPs) simultaneously from the left (O1) and right (O2) occipital cortices (80% contrast 60', 30', 15', and 7.5' checkerboard stimuli reversed at 2 Hz) in 22 patients with MA and 20 control subjects. The main outcome measure was interhemispheric asymmetry (IA) for both implicit time and amplitude, defined as the difference between the left and right scalp derivation (in absolute values).
  
  
  RESULTS
  IA was significantly different in patients with MA with respect to controls when employing 60' (p<0.001) and 15' (p<0.05) checkerboard stimuli for implicit times, and 60' (p<0.05) checkerboard stimuli for amplitudes. On the other hand, IA was not statistically different (p>0.05) in patients with MA with respect to controls when employing 30' and 7.5' checkerboards for both implicit times and amplitudes, and 15' checkerboards for amplitudes. No correlations were found between IA and age, onset of disease, attack frequency, or side of headache/aura.
  
  
  CONCLUSIONS
  Patients with MA presented asymmetries in VEP responses not related to visual aura or to headache side during the pain-free phase. These abnormalities may be ascribed to abnormal visual information processing, resulting in a different cortical activation when both foveal and parafoveal stimuli are used.
authors.affiliation: G.B. Bietti Eye Foundation, IRCCS, Roma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Coppola
authors.forename: V
authors.initials: V
authors.lastname: Parisi
authors.forename: G
authors.initials: G
authors.lastname: Fiermonte
authors.forename: R
authors.initials: R
authors.lastname: Restuccia
authors.forename: F
authors.initials: F
authors.lastname: Pierelli
mesh_terms: D000293:Adolescent; D000328:Adult; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000503:physiopathology*; D009778:Occipital Lobe / Q000503:physiopathology; D010775:Photic Stimulation; D012720:Severity of Illness Index