Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
BACKGROUND
Mutations in the LRRK2 gene are an important cause of familial and nonfamilial parkinsonism. Despite pleomorphic pathology, LRRK2 mutations are believed to manifest clinically as typical Parkinson disease (PD). However, most genetic screens have been limited to PD clinic populations.


OBJECTIVE
To clinically characterize LRRK2 mutations in cases recruited from a spectrum of neurodegenerative diseases.


METHODS
We screened for the common G2019S mutation and several additional previously reported LRRK2 mutations in 434 individuals. A total of 254 patients recruited from neurodegenerative disease clinics and 180 neurodegenerative disease autopsy cases from the University of Pennsylvania brain bank were evaluated.


RESULTS
Eight cases were found to harbor a LRRK2 mutation. Among patients with a mutation, two presented with cognitive deficits leading to clinical diagnoses of corticobasal syndrome and primary progressive aphasia.


CONCLUSIONS
The clinical presentation of LRRK2-associated neurodegenerative disease may be more heterogeneous than previously assumed.
Chen-Plotkin
A S
AS
Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.
Yuan
W
W
Anderson
C
C
McCarty Wood
E
E
Hurtig
H I
HI
Clark
C M
CM
Miller
B L
BL
Lee
V M-Y
VM
Trojanowski
J Q
JQ
Grossman
M
M
Van Deerlin
V M
VM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018888:Aphasia, Primary Progressive / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D020271:Heredodegenerative Disorders, Nervous System / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D010641:Phenotype; D011237:Predictive Value of Tests; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
D005819:Genetic Markers; C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases