title: Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test.
abstract: OBJECTIVE
  To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents.
  
  
  METHODS
  Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured.
  
  
  RESULTS
  Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significantly reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48).
  
  
  CONCLUSIONS
  Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.
authors.affiliation: Experimental Medicine Group, Lutheran University of Brazil, Canoas, Rio Grande do Sul, Brazil.
authors.forename: Leandro
authors.initials: L
authors.lastname: Ciulla
authors.forename: Honório Sampaio
authors.initials: HS
authors.lastname: Menezes
authors.forename: Bárbara Beatriz Moreira
authors.initials: BB
authors.lastname: Bueno
authors.forename: Alexandre
authors.initials: A
authors.lastname: Schuh
authors.forename: Rafael José Vargas
authors.initials: RJ
authors.lastname: Alves
authors.forename: Milena Pacheco
authors.initials: MP
authors.lastname: Abegg
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy*; D000068736:Duloxetine Hydrochloride; D005473:Fluoxetine / Q000494:pharmacology*; D007103:Immobilization / Q000523:psychology; D008297:Male; D023421:Models, Animal; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013550:Swimming / Q000523:psychology; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D005473:Fluoxetine; D000068736:Duloxetine Hydrochloride