Recombinant human zona pellucida protein C produced in Chinese hamster ovary cells binds to human spermatozoa and inhibits sperm-zona pellucida interaction.
Recombinant human zona pellucida protein C expressed in Chinese hamster ovary cells associates to the acrosomal region of human spermatozoa and inhibits sperm-zona pellucida interaction in the hemizona assay. Recombinant human zona pellucida protein C may be a useful tool toward the development of diagnostic methods for male factor infertility and the elucidation of the molecular basis of fertilization.
Marín-Briggiler
Clara I
CI
Instituto de Biología y Medicina Experimental, National Research Council of Argentina (CONICET), Buenos Aires, Argentina.
Gonzalez-Echeverría
María F
MF
Harris
Jeffrey D
JD
Vazquez-Levin
Mónica H
MH
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D005306:Fertilization / Q000502:physiology*; D006801:Humans; D011485:Protein Binding; D011486:Protein C / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D015044:Zona Pellucida / Q000378:metabolism*
D011486:Protein C; D011994:Recombinant Proteins