Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived Fungus Aspergillus candidus IF10.
Three novel cytotoxic substances named prenylterphenyllin (1), 4''-deoxyprenylterphenyllin (2), and 4''-deoxyisoterprenin (3) were isolated from a cultured marine-derived fungus of Aspergillus candidus IF10 together with 4''-deoxyterprenin (4). Their chemical structures were elucidated on the basis of 2D NMR analysis. These compounds 1 approximately 4 showed cytotoxic activity against human epidermoid carcinoma KB cells (KB3-1) with IC(50) of 8.5, 3.0, 2.5, and 4.5 microg/ml, respectively.
Wei
Hong
H
Graduate School of Pharmaceutical Sciences, Osaka University, Japan.
Inada
Hirohiko
H
Hayashi
Asami
A
Higashimoto
Kenichi
K
Pruksakorn
Patamaporn
P
Kamada
Sayo
S
Arai
Masayoshi
M
Ishida
Shunsuke
S
Kobayashi
Motomasa
M
D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D013730:Terphenyl Compounds / Q000302:isolation & purification / Q000494:pharmacology*
C525274:4''-deoxyisoterprenin; C525273:4''-deoxyprenylterphenyllin; C112886:4''-deoxyterprenin; D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D013730:Terphenyl Compounds; C525272:prenylterphenyllin