Expression of the sigmaF-directed csfB locus prevents premature appearance of sigmaG activity during sporulation of Bacillus subtilis.
During sporulation, sigma(G) becomes active in the prespore upon the completion of engulfment. We show that the inactivation of the sigma(F)-directed csfB locus resulted in premature activation of sigma(G). CsfB exerted control distinct from but overlapping with that exerted by LonA to prevent inappropriate sigma(G) activation. The artificial induction of csfB severely compromised spore formation.
Chary
Vasant K
VK
Department of Microbiology and Immunology, Temple University School of Medicine, 3400 North Broad St., Philadelphia, PA 19140, USA.
Xenopoulos
Panagiotis
P
Piggot
Patrick J
PJ
D001412:Bacillus subtilis / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D012808:Sigma Factor / Q000378:metabolism*; D013171:Spores, Bacterial / Q000235:genetics* / Q000378:metabolism*; D013997:Time Factors
D001426:Bacterial Proteins; C064971:FliA protein, Bacteria; D012808:Sigma Factor