[Increased IgE-type antibody response to food allergens in irritable bowel syndrome and inflammatory bowel diseases].
BACKGROUND
The irritable bowel syndrome (IBS) is a functional bowel disorder characterized by symptoms of abdominal pain that is associated with disturbed defecation. Crohn's disease (CD) and Ulcerative colitis (UC) are collectively referred to as inflammatory bowel diseases (IBD). IBD appears to result from dysregulated immune response with contributions from genetic predisposition and environmental factors. Among environmental factors the enteric microflora and the components of food (eg. antigens) may play important role in the pathogenesis of IBD. The aim of the authors' study was to detect IgE type antibodies against the most frequent food allergens in patients with IBD and IBS.


METHODS
Antibodies against food allergens (IgE type) with ELISA method in patients with CD, UC and IBS were quantitatively measured. The figures were compared to the result of a healthy control group contains the same number of participants, and the frequency of food allergy in these patient groups were determined.


RESULTS
On the basis of the study the presence of increased IgE type immune response against any food allergens was 34.5% (p = 0.01) in the group of IBS. In patients with CD or UC the immune response against food allergens was also more frequent than in the control group. The order of frequency of food allergens in IBS was the following: milk protein, soybean, tomato, peanut, egg white.


CONCLUSIONS
As the occurrence of food allergens was significantly higher in IBS group than in the control group, the role of food allergy in the symptoms of IBS can be come up. The frequency of food allergy in patients with diagnosis of IBS, and the similarity of symptoms of this two diseases give an obvious opportunity for the patients with IBS to use a diet avoiding the most frequent food allergens, or take e.g. Na-cromoglycate which is useful therapy in food allergy.
Mekkel
Gabriella
G
Orvos- és Egészségtudományi Centrum, Altalános Orvostudományi Kar, Belgyógyászati Intézet, III. Belgyógyászati Klinika. ella@iiibel.dote.hu
Barta
Zsolt
Z
Ress
Zsuzsa
Z
Gyimesi
Edit
E
Sipka
Sándor
S
Zeher
Margit
M
D000328:Adult; D000485:Allergens / Q000276:immunology*; D000906:Antibodies / Q000097:blood*; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000276:immunology; D003424:Crohn Disease / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D015212:Inflammatory Bowel Diseases / Q000209:etiology / Q000276:immunology*; D043183:Irritable Bowel Syndrome / Q000209:etiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D000485:Allergens; D000906:Antibodies; D007073:Immunoglobulin E