title: [Adaptive designs for clinical trial].
abstract: OBJECTIVE
  In order to provide readers with general concepts and methodology on adaptive designs for clinical trial.
  
  
  METHODS
  Definition of adaptive designs for clinical trial and basic idea of adaptive adjustment were introduced through an example.
  
  
  RESULTS
  The relationship between adaptive designs and group sequential design was summarized. Ways to embody two basic statistical rules of clinical trial under adaptive adjustments setting were also introduced.
  
  
  CONCLUSIONS
  Adaptive designs provided clinical trial with a great flexibility, which could greatly improve the efficiency of clinical trial.
authors.affiliation: Division of Biometrics, National Center for Cardiovascular Diseases, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Shan-ju
authors.initials: SJ
authors.lastname: He
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiao-ru
authors.initials: XR
authors.lastname: Cheng
authors.forename: Xuan
authors.initials: X
authors.lastname: Jia
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D012107:Research Design