An esterase-activated magnetic resonance contrast agent.
A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO(3)(-)/CO(3)(2-) binding by the resulting negative charge.
Giardiello
Marco
M
Department of Chemistry, University Road, University of Leicester, Leicester, UK LE1 7RH.
Lowe
Mark P
MP
Botta
Mauro
M
D000818:Animals; D003287:Contrast Media / Q000737:chemistry*; D004950:Esterases / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013552:Swine; D014867:Water / Q000737:chemistry
D003287:Contrast Media; D014867:Water; D004950:Esterases