title: Effects of treatments on the mortality of Stevens-Johnson syndrome and toxic epidermal necrolysis: A retrospective study on patients included in the prospective EuroSCAR Study.
abstract: BACKGROUND
  No treatment modality has been established as standard for patients with Stevens-Johnson syndrome and toxic epidermal necrolysis.
  
  
  OBJECTIVE
  We sought to evaluate the effect of treatment on mortality in a large cohort of patients with Stevens-Johnson syndrome or toxic epidermal necrolysis.
  
  
  METHODS
  Data on therapy were retrospectively collected from patients in France and Germany enrolled in EuroSCAR, a case-control study of risk factors.
  
  
  RESULTS
  Neither intravenous immunoglobulins nor corticosteroids showed any significant effect on mortality in comparison with supportive care only. Compared with supportive care, odds ratios for death were 1.4 (95% confidence interval: 0.6-4.3) for intravenous immunoglobulins in France and 1.5 (0.5-4.4) in Germany, and 0.4 (0.1-1.7) for corticosteroids in France and 0.3 (0.1-1.1) in Germany.
  
  
  CONCLUSIONS
  Such an observational study with retrospective data collection has obvious limitations, including heterogeneity between the countries, supportive care, treatment doses, and durations.
  
  
  CONCLUSIONS
  We found no sufficient evidence of a benefit for any specific treatment. The trend for a beneficial effect of corticosteroids deserves further exploration.
authors.affiliation: Dokumentationszentrum schwerer Hautreaktionen, University Medical Center Freiburg, Freiburg, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schneck
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Fagot
authors.forename: Peggy
authors.initials: P
authors.lastname: Sekula
authors.forename: Bruno
authors.initials: B
authors.lastname: Sassolas
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Roujeau
authors.forename: Maja
authors.initials: M
authors.lastname: Mockenhaupt
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005602:France; D005858:Germany; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy* / Q000401:mortality*
chemical_list: D000305:Adrenal Cortex Hormones; D016756:Immunoglobulins, Intravenous