[Antiretroviral therapies: strategic perspectives for the future].
The main goal of antiretroviral therapy (ART) is to decrease control serum virus load (CVL) by maintaining replication at less than 50 copies. Sustained suppression of replication results in recovery of the immune response. Current ART regimens are not only effective but also well-tolerated thus improving patient life quality. Adherence is an important factor in achieving sustained suppression of replication. Several parameters must be considered, i.e., when to initiate therapy, how to determine the most effective combination, and whether protease inhibitors (PI) are powerful enough for monotherapy. Treatment must optimize the genetic barrier to avoid appearance of resistant mutants that could lead to failure in case of non-compliance. Initial treatment must include secondary therapeutic possibilities, which means choosing treatments that can lead to uncrossed mutations.
Dellamonica
P
P
Service d'infectiologie, CHU de Nice, France. dellamonica.p@chu-nice.fr
Pugliese
P
P
Durant
J
J
D023241:Antiretroviral Therapy, Highly Active / Q000379:methods* / Q000639:trends*; D018791:CD4 Lymphocyte Count; D005544:Forecasting; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D011788:Quality of Life