title: A MIP-based impedimetric sensor for the detection of low-MW molecules.
abstract: Mimicking the selectivity and sensitivity of biological systems for sensor devices is of increasing interest in biomedical, environmental and chemical analysis. Synthetic materials with imprinted nanocavities, acting as highly selective artificial receptors, are a tailor-made solution in obtaining such a sensor. Incorporation of such molecularly imprinted polymers (MIPs) in a platform suitable for electrochemical measurements, can offer high sensitivity together with device miniaturization and an electronic read-out. As a proof of principle, a MIP-based sensor for L-nicotine has been developed. To this end, the molecular structure of L-nicotine was imprinted in a polymer matrix of polymethacrylic acid (PMAA). Subsequently, microparticles of the imprinted polymer were immobilized on thin films of the conjugated polymer OC(1)C(10)-PPV. These films were incorporated in an impedimetric sensing device. Using electrochemical impedance spectroscopy, the real part of the impedance was monitored for various concentrations. This setup allows for the detection of l-nicotine from 1 to 10 nM and is insensitive for the resembling molecule L-cotinine.
authors.affiliation: Hasselt University, Institute for Materials Research, Wetenschapspark 1, B-3590 Diepenbeek, Belgium. ronald.thoelen@uhasselt.be
authors.forename: R
authors.initials: R
authors.lastname: Thoelen
authors.forename: R
authors.initials: R
authors.lastname: Vansweevelt
authors.forename: J
authors.initials: J
authors.lastname: Duchateau
authors.forename: F
authors.initials: F
authors.lastname: Horemans
authors.forename: J
authors.initials: J
authors.lastname: D'Haen
authors.forename: L
authors.initials: L
authors.lastname: Lutsen
authors.forename: D
authors.initials: D
authors.lastname: Vanderzande
authors.forename: M
authors.initials: M
authors.lastname: Ameloot
authors.forename: M
authors.initials: M
authors.lastname: vandeVen
authors.forename: T J
authors.initials: TJ
authors.lastname: Cleij
authors.forename: P
authors.initials: P
authors.lastname: Wagner
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D003367:Cotinine / Q000032:analysis; D017097:Electric Impedance; D004566:Electrodes; D008970:Molecular Weight; D009538:Nicotine / Q000032:analysis*; D011108:Polymers / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D011108:Polymers; D009538:Nicotine; D003367:Cotinine