title: Preoperative clinical status but not waiting time predicts in-hospital outcomes of surgery in patients with left main coronary artery stenosis.
abstract: Contoversy exists about the optimal operation time of the patients with left main coronary artery (LMCA) stenosis. We therefore, aimed to investigate the effect of waiting time on in-hospital morbidity and mortality in patients with LMCA stenosis and identify the risk factors associated with adverse cardiovascular events before and during surgery. One hundred seventy six patients with LMCA stenosis were divided into two groups according to the time period between coronary angiography and coronary artery bypass surgery (group 1: <or= 7 days, 94 patients; and group 2: > 7 days, 82 patients). Primary end points were death and major adverse cardiac event (MACE): in-hospital death, sustained ventricular tachycardia or ventricular fibrillation development, postoperative stay in the intensive care > 48 hrs and in hospital > 9 days. Demographic and clinical characteristics of patients in groups 1 and 2 were comparable. There was no difference between the two groups in terms of in-hospital morbidity, mortality and MACE. When we analyzed the differences between the patients with and without MACE, the patients who experienced MACE were older (p = 0.001), and had higher degree of LMCA stenosis (p = 0.01), higher degree of right coronary artery stenosis (p = 0.02), higher blood urea level (p = 0.003), and higher incidence of unstable angina or myocardial infarction within 2 weeks (p = 0.001). Independent risk factors for MACE were unstable angina or myocardial infarction within 2 weeks, age more than 70 years and stenosis more than 75% in the LMCA. These results suggest that preoperative clinical status but not waiting time predicts in-hospital surgical outcomes in LMCA stenosis.
authors.affiliation: Gaziantep University, School of Medicine, Department of Cardiology, Gaziantep, Turkey. drisari@yahoo.com
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sari
authors.forename: Zubeyir
authors.initials: Z
authors.lastname: Acar
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Nurkalem
authors.forename: Nevzat
authors.initials: N
authors.lastname: Uslu
authors.forename: Vedat
authors.initials: V
authors.lastname: Davutoglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ates
authors.forename: Orhan
authors.initials: O
authors.lastname: Ozer
authors.forename: Mehmet
authors.initials: M
authors.lastname: Eren
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aksoy
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data; D023921:Coronary Stenosis / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006304:Health Status; D006801:Humans; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011300:Preoperative Care; D013997:Time Factors; D016896:Treatment Outcome; D014850:Waiting Lists