Cerebral Aspergillus arteritis with bland infarcts: a report of two patients with poor outcome.
Two patients with cerebrovascular aspergillosis, in the form of arteritis, thrombosis and bland infarcts are reported. One patient had systemic lupus erythematosus with disseminated aspergillosis in lungs, kidneys and brain. The other patient was immunocompetent and had sphenoid sinusitis. Both the patients were diagnosed at autopsy only, despite extensive imaging and laboratory studies. High index of clinical suspicion and early aggressive antifungal therapy are required since definite diagnostic modalities are not available.
Uppin
Megha S
MS
Department of Pathology, NIMS, Panjagutta, Hyderabad andhra Pradesh, India.
Challa
Sundaram
S
Uppin
Shantveer G
SG
Alladi
Suvarna
S
Yarlagadda
Jyotsna Rani
JR
D000293:Adolescent; D000328:Adult; D001230:Aspergillus / Q000472:pathogenicity*; D002941:Circle of Willis / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D007238:Infarction / Q000382:microbiology* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D020953:Neuroaspergillosis / Q000150:complications / Q000473:pathology*; D013788:Thalamus / Q000382:microbiology / Q000473:pathology; D020293:Vasculitis, Central Nervous System / Q000150:complications / Q000473:pathology*