Haversian remodeling in guided bone regeneration with calcium alginate film in circular bone defect model of rabbit.
The objective of this study is to investigate the effect of bioabsorbable Calcium alginate film in guided bone regeneration by the study of Haversian remodeling. Circular bone defects of 5 mm diameter were created in the corners of mandibles in 35 rabbits. The defects were covered with calcium alginate film (CAF) served as the experimental group, or collagen membrane (CM) as the control group, respectively. Healing condition was analyzed with gross, histological and immunohistochemical studies after 1, 2, 4, 6 and 8 weeks. The experimental group appeared more and earlier Haversian remodeling and osteoinductive factors leading to better bone regeneration. The control group showed more macrophages, less and later Haversian remodeling, absorbed slowly, while collected fewer osteoinductive factors in the early stage. Calcium alginate film, which is a relatively cheaper material, provides better effect than the collagen membrane in bone regeneration, Haversian remodeling and quantity of osteoinductive factors.
He
Hong
H
Department of Stomatology, Second Affiliated Hospital, College of Medicine, Zhe Jiang University, Hang Zhou, China.
Huang
Jianqi
J
Shi
Jiejun
J
Ping
Feiyun
F
Chen
Guanfu
G
Dong
Yan
Y
D000464:Alginates / Q000627:therapeutic use*; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use; D004195:Disease Models, Animal; D020723:Glucuronic Acid / Q000627:therapeutic use; D006253:Haversian System / Q000254:growth & development* / Q000293:injuries / Q000502:physiology; D006603:Hexuronic Acids / Q000627:therapeutic use; D008297:Male; D008334:Mandible / Q000502:physiology; D008338:Mandibular Injuries / Q000473:pathology / Q000628:therapy; D011817:Rabbits
D000464:Alginates; D018786:Bone Substitutes; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D003094:Collagen