[The heat shock protein 70-2 gene +1267(A/G) polymorphism and susceptibility to ankylosing spondylitis in Chinese Han population].
OBJECTIVE
To investigate the association between the heat shock protein 70-2 gene polymorphism and ankylosing spondylitis (AS).


METHODS
The polymorphisms of HSP70-2 gene Pst I 1267 site were analysed in 176 Chinese Han AS patients and 127 healthy controls by PCR and restriction fragment length polymorphisms(RFLP) methods.


RESULTS
In AS patients HSP70-2 genotypes AA, AG and GG were 46.6%, 46.0% and 7.4% respectively, frequencies of A and G were 69.6%(A) and 30.4%(G). In healthy controls HSP70-2 genotypes AA, AG and GG were 44.1%, 48.8% and 6.9% respectively, frequencies of A and G were 68.5%(A)and 31.5%(G). No significant differences were found in the distribution of HSP70-2 genotypes and allele frequencies between AS patients and controls.


CONCLUSIONS
Our results indicate that the there may be no association of the HSP70-2 gene polymorphism with AS in Chinese Han population.
Lin
Jing-an
JA
Center of Research, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005 PR China. jinganlin@126.com
Li
Wen-qing
WQ
Ye
De-fu
DF
Xue
Yuan
Y
Chen
Rui-qing
RQ
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002648:Child; D002681:China / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013167:Spondylitis, Ankylosing / Q000235:genetics*
D018840:HSP70 Heat-Shock Proteins