Stage I ovarian carcinoma: different clinical pathologic patterns.
OBJECTIVE
To analyze clinicopathologic patterns of early ovarian carcinoma.


METHODS
Retrospective chart and histopathology review.


METHODS
Mount Sinai School of Medicine, New York and the Centre Jean Perrin, Clermont Ferrand, France.


METHODS
Seventy-six consecutive cases of Fédération Internationale de Gynécologie et d'Obstétrique stage I ovarian carcinoma.


METHODS
Surgical staging.


METHODS
Symptomatology, pathology, and histology analysis.


RESULTS
Twenty-two cases (29%) were serous papillary carcinomas and 54 were nonserous carcinomas (71%) (40 endometrioid, 10 clear cell, and 4 mixed endometrioid and clear cell carcinomas). Ninety-eight percent of ovarian endometriosis, 95% of endometrial carcinomas, and 83% of endometrial polyps and hyperplasias were associated with nonserous carcinomas. Most patients with serous papillary carcinoma presented with asymptomatic pelvic masses; patients with nonserous carcinomas presented with pelvic pain or abnormal vaginal bleeding with or without pelvic mass.


CONCLUSIONS
Over two thirds of stage I ovarian carcinomas were nonserous, and were diagnosed because of associated symptoms: pelvic pain with endometriosis and/or adnexal masses, or vaginal bleeding from endometrial pathology. Serous papillary carcinomas were often asymptomatic and diagnosed during follow-up evaluations in breast cancer patients. Stage I ovarian carcinoma has different clinical and pathologic patterns than advanced ovarian carcinoma. The risk of ovarian and endometrial malignancy should be taken into consideration during evaluation of patients with endometriosis and breast cancer histories.
Deligdisch
Liane
L
The Mount Sinai School of Medicine, Department of Pathology, New York, NY 10029, USA.
Pénault-Llorca
Frédérique
F
Schlosshauer
Peter
P
Altchek
Albert
A
Peiretti
Michele
M
Nezhat
Farr
F
D018262:Adenocarcinoma, Clear Cell / Q000473:pathology; D018269:Carcinoma, Endometrioid / Q000473:pathology; D002291:Carcinoma, Papillary / Q000473:pathology; D018283:Cystadenocarcinoma, Papillary / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology*; D012189:Retrospective Studies