Steroid use in sepsis-induced conjugated hyperbilirubinemia: report of one case.
We report a girl with acute lymphoblastic leukemia who developed severe conjugated hyperbilirubinemia (total bilirubin 34.32 mg/dl, direct bilirubin 26.94 mg/dl) following gram-negative (Escherichia coli ) sepsis. Despite broad-spectrum antibiotics, her hyperbilirubinemia progressed. Her mental status deteriorated and steroid therapy (hydrocortisone 8 mg/kg/d) was initiated. Her condition then recovered rapidly. Based on our findings, we suggest that steroid may help to treat progressive conjugated hyperbilirubinemia due to gram-negative sepsis.
Wang
Jinn-Li
JL
Department of Pediatrics, Taipei Medical University-Wan Fang Medical Center, Taiwan. jlwang@wanfang.gov.tw
Ou
Tsong-Yih
TY
Chen
Chun-Nan
CN
Shen
Ein-Yiao
EY
D016470:Bacteremia / Q000150:complications*; D002648:Child; D004927:Escherichia coli Infections / Q000150:complications*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D006932:Hyperbilirubinemia / Q000188:drug therapy / Q000209:etiology*; D010289:Parenteral Nutrition, Total
D006854:Hydrocortisone