Aberrant sialylation of serum IgA1 was associated with prognosis of patients with IgA nephropathy.
Aberrant glycosylation of serum IgA1 was considered as an initial event and involvement in the pathogenesis of IgAN. We previously demonstrated that aberrant glycosylation of serum IgA1 was associated with pathologic phenotype of IgAN. The present study is to investigate if abnormal sialylation of IgA1 affects renal survival of IgAN. 127 patients with biopsy-proven IgAN were enrolled and followed up to 8 years. Seventy-nine healthy and 75 patients with non-IgAN renal diseases were selected as controls. Alpha 2, 6 sialic acid (SA) of serum IgA1 was measured by sandwich-ELISA. Renal survival rate was estimated by Kaplan-Meier method. Alpha 2, 6 SA level in patients with IgAN was lower than that in healthy controls (0.92+/-0.14 vs. 0.98+/-0.12, P=0.001) and non-IgAN glomerulonephritis (0.92+/-0.14 vs. 1.00+/-0.18, n=53, P=0.001). Patients with IgAN in Low SA Group were no significant differences compared with patients in Normal SA Group in age, gender, hypertension, serum creatinine, and excretion of proteinuria. Renal cumulative survival rate was 53.3% in patients in Low SA Group and 83.5% in Normal SA Group (P=0.0008). The lower the alpha 2, 6 SA level of serum IgA1 in patients with IgAN was, the worse their renal survival rate was. Although patients in Low SA Group had worse renal function evaluated by eGFR, there was no significant difference in various CKD stages in non-IgAN renal function controls (n=42, P=0.352). Alpha 2, 6 SA level of serum IgA1 was associated with the prognosis of patients with IgAN and could serve as a predictor of poor prognosis in IgAN.
Ding
Jia-Xiang
JX
Renal Division of Peking University First Hospital, Peking University Institute of Nephrology, Beijing 100034, PR China.
Xu
Li-Xia
LX
Lv
Ji-Cheng
JC
Zhao
Ming-Hui
MH
Zhang
Hong
H
Wang
Hai-Yan
HY
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000401:mortality*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D053208:Kaplan-Meier Estimate; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D011379:Prognosis
D007070:Immunoglobulin A; D019158:N-Acetylneuraminic Acid