title: Type 2 diabetes mellitus: phylogenetic motifs for predicting protein functional sites.
abstract: Diabetes mellitus, commonly referred to as diabetes, is a medical condition associated with abnormally high levels of glucose (or sugar) in the blood. Keeping this view, we demonstrate the phylogenetic motifs (PMs) identification in type 2 diabetes mellitus very likely corresponding to protein functional sites. In this article, we have identified PMs for all the candidate genes for type 2 diabetes mellitus. Glycine 310 remains conserved for glucokinase and potassium channel KCNJ11. Isoleucine 137 was conserved for insulin receptor and regulatory subunit of a phosphorylating enzyme. Whereas residues valine, leucine, methionine were highly conserved for insulin receptor. Occurrence of proline was very high for calpain 10 gene and glucose transporter.
authors.affiliation: Bioinformatics Division, Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 226 015, India. ashoksharma@cimap.res.in
authors.forename: Ashok
authors.initials: A
authors.lastname: Sharma
authors.forename: Tanuja
authors.initials: T
authors.lastname: Rastogi
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Bhartiya
authors.forename: A K
authors.initials: AK
authors.lastname: Shasany
authors.forename: S P S
authors.initials: SP
authors.lastname: Khanuja
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics* / Q000502:physiology; D001665:Binding Sites / Q000235:genetics; D020134:Catalytic Domain / Q000235:genetics; D017124:Conserved Sequence; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D010802:Phylogeny; D011237:Predictive Value of Tests; D011506:Proteins / Q000235:genetics* / Q000502:physiology; D020539:Sequence Analysis, Protein; D017386:Sequence Homology, Amino Acid
chemical_list: D011506:Proteins