The efficiency of excretory urography to detect upper urinary tract tumors after cystectomy for urothelial cancer.
OBJECTIVE
We determined the efficiency of routine excretory urography for detecting tumor recurrence in the upper urinary tract after cystectomy and urinary diversion for bladder cancer.


METHODS
We evaluated 322 patients who underwent cystectomy and urinary diversion, and had undergone routine followup, including regular excretory urography 1, 2, 3, 5, 7 and 10 years after cystectomy.


RESULTS
Upper urinary tract recurrence was found in 15 of the 322 patients (4.7%) patients. Eight of 15 cases were detected by routine excretory urography, resulting in a low efficiency of 0.75% (8 of 1,064 studies) for this method. The remaining 7 recurrences were detected as a result of symptoms such as macrohematuria or flank pain occurring between routine followup examinations. Patients were at up to 10 times higher risk for recurrence in the upper urinary tract if they had positive distal ureteral resection margins or a history of upper urinary tract tumors. Although the incidence of recurrence in the upper urinary tract increased 1.8-fold in patients with pTa/pT1 tumors, it remained relatively low at 8.4%.


CONCLUSIONS
The incidence of recurrence in the upper urinary tract a median of 49 months (range 12 to 220) after cystectomy for transitional cell carcinoma was 4.7%. Because only half of these cases were detected by routine excretory urography, this should be limited to patients at high risk with a history of upper urinary tract tumors or positive ureteral margins. In the future other techniques, eg cytology of voided urine or new markers, should be evaluated to replace excretory urography for routine followup of patients after cystectomy for transitional cell carcinoma of the bladder.
Meissner
Claudia
C
Department of Urology and Institute of Diagnostic Radiology, University of Bern, Bern, Switzerland.
Giannarini
Gianluca
G
Schumacher
Martin C
MC
Thoeny
Harriet
H
Studer
Urs E
UE
Burkhard
Fiona C
FC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002295:Carcinoma, Transitional Cell / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D015653:Cystectomy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D014567:Urography / Q000379:methods*