title: Is there any prognostically different subgroup among patients with stage IIIC (any TN3M0) breast carcinoma?
abstract: BACKGROUND
  We investigated whether there are prognostically different subgroups among patients with stage IIIC (any TN3M0) breast carcinoma.
  
  
  METHODS
  The file records of 348 female patients operated for stage IIIC breast carcinoma were reviewed. The endpoint was disease recurrence.
  
  
  RESULTS
  Patients with a T1, T2 or T3 tumor had significantly better disease-free survival (DFS) compared to those with a T4 tumor. In the patient group with T1,2,3N3M0 disease, the DFS was significantly better in patients with between 10 and 15 metastatic axillary lymph nodes, compared to patients with 16 or more metastatic lymph nodes (p = 0.0360) and in patients with a nodal ratio ( number of metastatic lymph nodes divided by number of removed nodes) less than or equal to 0.80, compared to patients with a nodal ratio greater than 0.80 (p = 0.0003). In the patient subgroup with between 10 and 15 metastatic lymph nodes, those with a nodal ratio greater than 0.80 had significantly worse DFS, whereas in the patient subgroup with 16 or more metastatic lymph nodes the nodal ratio had no prognostic significance. The DFS of patients with 10 to 15 positive lymph nodes and a nodal ratio of up to 0.80 was significantly better than that of both the patients with 10 to 15 positive lymph nodes and a nodal ratio greater than 0.80 (p = 0.0002), and the patients with 16 or more positive lymph nodes (p = 0.0002); survival of the latter two patient groups was similar.
  
  
  CONCLUSIONS
  Patients with T1,2,3N3M0 disease can be divided into prognostically different subgroups according to the number of metastatic lymph nodes in the axilla and the nodal ratio; in this way, different patient subgroups may be offered different treatment strategies.
authors.affiliation: Fifth Department of Surgery, SSK Okmeydani Training Hospital, Istanbul, Turkey. nduraker@hotmail.com
authors.forename: Nüvit
authors.initials: N
authors.lastname: Duraker
authors.forename: Zeynep C
authors.initials: ZC
authors.lastname: Caynak
authors.forename: Bakir
authors.initials: B
authors.lastname: Bati
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla / Q000473:pathology; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging / Q000145:classification*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies