Catch the KIF5B train to the apical surface.
As epithelial cells become polarized, they develop new pathways to send proteins to the apical or basolateral domains of their plasma membrane. In this issue of Developmental Cell, Jaulin et al. (2007) show that as polarity develops, there is a shift in the kinesin motor protein used to transport an apical protein to the cell surface.
Jacobson
Catherine
C
Department of Anatomy and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.
Mostov
Keith
K
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D016764:Cell Polarity / Q000502:physiology; D004285:Dogs; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D016547:Kinesins / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism*; D008870:Microtubules / Q000502:physiology; D021381:Protein Transport
C488101:KIF5B protein, human; D008565:Membrane Proteins; D016547:Kinesins