title: PD and loss of peritoneal function.
abstract: During long-term treatment with peritoneal dialysis both peritoneal membrane structure and function undergo significant changes that not only correlate with the time under treatment, but also with the frequency and severity of infections. In addition, peritoneal dialysis fluid bio-incompatibility may constitute a hazard for the longevity of the peritoneum as the dialysis membrane. In particular, the presence of glucose degradation products may lead to impaired peritoneal cell function as well as to increased protein glycation and peritoneal AGE deposition. Results from recent prospective randomised studies suggest that treatment with new GDP-depleted PD fluids may lead to a significant improvement of clinical outcomes in PD patients.
authors.affiliation: Department of Nephrology and Medical Intensive Care, Charité University Hospital, Campus Virchow-Klinikum, Berlin, Germany. achim.joerres@charite.de
authors.forename: A
authors.initials: A
authors.lastname: Jörres
authors.forename: J
authors.initials: J
authors.lastname: Witowski
authors.forename: T O
authors.initials: TO
authors.lastname: Bender
mesh_terms: D015312:Hemodialysis Solutions; D006801:Humans; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010537:Peritoneum / Q000503:physiopathology*
chemical_list: D015312:Hemodialysis Solutions