[Genetic polymorphisms of short tandem repeat loci D4S2368, D6S1043, D9S925 from Korean ethnic group of JiLin].
OBJECTIVE
To understand the allele structure and genetic polymorphism at D4S2368, D6S1043, D9S925 short tandem repeat (STR) loci in Korean ethnic group of Jilin, and to construct a preliminary database.


METHODS
The allele frequencies of the three STRs loci in 310 unrelated individuals from Korean ethnic individuals were analyzed by polymerase chain reaction (PCR) and polyacrylamide gel electrophoresis (PAGE).


RESULTS
Seven, thirteen, and nine alleles were observed at D4S2368, D6S1043, and D9S925 loci, respectively, and all loci met Hardy-Weinberg equilibrium (except D6S1043). The statistical analysis of 3 STR loci showed the heterozygosities were more than 0.717, the polymorphic information contents (PIC) were more than 0.670; the combined power of discrimination (PD) and the power of exclusion (PE) were more than 0.9995 and 0.952 respectively.


CONCLUSIONS
The three loci in this study are found to have high heterozygosity and polymorphic information content, so they can provide useful markers for genetic purposes. These results could serve as valuable data to enrich the Korean ethnic group genetic database and play an important role in Chinese population genetic application.
Zhang
Yong-ji
YJ
Department of Forensic Medicine, College of Medicine, Yanbian University, Yanji, Jilin, 133000 PR China. zhangyj@ybu.edu.cn
Zhang
Hong-jiang
HJ
Sun
Shu
S
Xuan
Yan-hua
YH
D044466:Asian People / Q000235:genetics*; D030541:Databases, Genetic; D005006:Ethnicity / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D007723:Korea / Q000208:ethnology; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic
D005819:Genetic Markers