[24-h dynamics of urination in patients with overactive urinary bladder].
Home 3-day uroflowmetry was made in 41 female patients (mean age 46 years) before and after therapy for overactive bladder (OB). The course of therapy lasting from 6 weeks to 3 months included M-cholinolytics and vascular medication. Estimation of the bladder capacity in different time of 24-h period revealed circadian deviations of urinary flow and volumes. Administration of short-term M-cholinolytics enables chronotherapy providing maximal effects within 4-6 hours, possibility to vary doses. In view of this, optimal cholinergic therapy of OB is trospium chloride which has necessary properties, high safety and wide dose range.
Danilov
V V
VV
Danilova
T I
TI
Danilov
V V
VV
Vodop'ianova
O A
OA
Vasil'chenko
A V
AV
Besedin
S V
SV
D000293:Adolescent; D000328:Adult; D000368:Aged; D001561:Benzilates; D018680:Cholinergic Antagonists / Q000008:administration & dosage; D019454:Chronotherapy / Q000379:methods; D002940:Circadian Rhythm / Q000187:drug effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D009662:Nortropanes / Q000008:administration & dosage; D010276:Parasympatholytics / Q000008:administration & dosage; D013997:Time Factors; D053201:Urinary Bladder, Overactive / Q000188:drug therapy / Q000503:physiopathology*; D014554:Urination / Q000187:drug effects
D001561:Benzilates; D018680:Cholinergic Antagonists; D009662:Nortropanes; D010276:Parasympatholytics; C003330:trospium chloride