Loss of T-bet sends host-microbe mutualism awry.
Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system.
Ma
Averil
A
Department of Medicine, Program in Biomedical Sciences, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0451, USA. averil.ma@ucsf.edu
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003093:Colitis, Ulcerative / Q000276:immunology*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D051379:Mice; D018345:Mice, Knockout; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D000098815:T-bet Transcription Factor
D018398:Homeodomain Proteins; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D014409:Tumor Necrosis Factor-alpha; C064658:RAG-1 protein