Perisomatic inhibition.
Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and "mood" (as a fine-tuning device), respectively, of network oscillations. Pathology extends this conclusion further, as the former is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex.
Freund
Tamás F
TF
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary. Freund@koki.hu
Katona
István
I
D000818:Animals; D001007:Anxiety / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000166:cytology*; D002766:Cholecystokinin / Q000378:metabolism; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons / Q000145:classification / Q000502:physiology; D010320:Parvalbumins / Q000378:metabolism
D010320:Parvalbumins; D002766:Cholecystokinin