Juvenile gout in Taiwan associated with family history and overweight.
OBJECTIVE
To examine the clinical features of juvenile gout and its possible association with familial juvenile hyperuricemic nephropathy (FJHN).


METHODS
A total of 543 cases of juvenile gout from the Ho-Ping Gout Database were enrolled, and 5269 gouty cases with onset age of 40 to 50 years were selected as a control group. Clinical and laboratory data were compared between the 2 groups.


RESULTS
In patients with juvenile gout, body mass index, serum urate concentration, 24-hour urinary uric acid excretion, and creatinine clearance were significantly higher than those in the control group (p < 0.0001), while fractional excretion of uric acid was significantly lower. Only 15% of the juvenile gout cases fulfilled the features of FJHN. The percentage of familial aggregation in juvenile gout was about 1.9-fold higher than that in the control group (44.3% vs 23.8%; p < 0.0001).


CONCLUSIONS
Juvenile gout in Taiwan is associated with overweight and hereditary background, while FJHN may not be primarily responsible.
Chen
Shih-Yang
SY
Center of Gout, Country Hospital, #61 Sec. 4 Ren-Ai Road, Taipei, Taiwan. doctor@rahome.idv.tw
Shen
Ming-Lai
ML
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D015992:Body Mass Index; D002648:Child; D005260:Female; D006073:Gout / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D006801:Humans; D033461:Hyperuricemia / Q000150:complications / Q000235:genetics; D007674:Kidney Diseases / Q000150:complications / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000473:pathology; D013624:Taiwan / Q000453:epidemiology