title: Vilsmeier-Haack reactions of 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans toward the synthesis of highly substituted pyridin-2(1H)-ones.
abstract: A facile and efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones was developed via Vilsmeier-Haack reactions of readily available enaminones, 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans, and a mechanism involving sequential ring-opening, haloformylation, and intramolecular nucleophilic cyclization reactions is proposed.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, China.
authors.forename: Dexuan
authors.initials: D
authors.lastname: Xiang
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Yongjiu
authors.initials: Y
authors.lastname: Liang
authors.forename: Wei
authors.initials: W
authors.lastname: Pan
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.forename: Dewen
authors.initials: D
authors.lastname: Dong
mesh_terms: D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry*; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011714:Pyrans; D011728:Pyridones