New molecular insights into cellular survival and stress responses: neuroprotective role of cellular prion protein (PrPC).
Knowledge of the physiological function of cellular prion protein has been acquired from prion diseases such as Creutzfeldt-Jakob disease, as well as PRNP knock out and transgenic mice. Recent progress in neurobiology has further delineated the neuroprotective role played by cellular prion protein. In this paper, we review the role of cellular prion protein in cell survival including its antiapoptotic effect on Bax-mediated cell death and its responses to various environmental stresses including oxidative stress, and ischemia. Finally, we discuss the significance of cellular prion protein in different neurodegenerative diseases and the possible development of future therapies.
Lo
Raymond Yen-Yu
RY
Department of Neurology, Neuro-Medical Scientific Center, Buddhist Tzu-Chi General Hospital, Tzu-Chi University, Hualien, Taiwan.
Shyu
Woei-Cherng
WC
Lin
Shinn-Zong
SZ
Wang
Hsiao-Jung
HJ
Chen
Shun-Sheng
SS
Li
Hung
H
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism; D016923:Cell Death / Q000502:physiology; D002470:Cell Survival / Q000502:physiology*; D004827:Epilepsy / Q000378:metabolism; D058851:GPI-Linked Proteins; D018869:Heat-Shock Response / Q000502:physiology; D007003:Hypoglycemia / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology; D018696:Neuroprotective Agents / Q000378:metabolism*; D018384:Oxidative Stress; D018621:PrPC Proteins / Q000378:metabolism*; D011328:Prions / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000378:metabolism
D058851:GPI-Linked Proteins; D018696:Neuroprotective Agents; C501125:PRND protein, human; D018621:PrPC Proteins; D011328:Prions; D051028:bcl-2-Associated X Protein