Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly.
Fluorescence in situ hybridization and real-time PCR analysis targeting the 16S rRNA gene of Akkermansia muciniphila were performed to determine its presence in the human intestinal tract. These techniques revealed that an A. muciniphila-like bacterium is a common member of the human intestinal tract and that its colonization starts in early life and develops within a year to a level close to that observed in adults (10(8) cells/g) but decreases (P < 0.05) in the elderly.
Collado
M Carmen
MC
Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, 5th floor, FI-20520 Turku, Finland. marcol@utu.fi
Derrien
Muriel
M
Isolauri
Erika
E
de Vos
Willem M
WM
Salminen
Seppo
S
D000328:Adult; D000369:Aged, 80 and over; D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D005243:Feces / Q000382:microbiology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007231:Infant, Newborn; D007422:Intestines / Q000382:microbiology*; D009077:Mucins / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S / Q000235:genetics
D009077:Mucins; D012336:RNA, Ribosomal, 16S