title: Coronary involvement in infants with Kawasaki disease treated with intravenous gamma-globulin.
abstract: OBJECTIVE
  To analyze the clinical spectrum and the incidence of coronary involvement in infants with typical Kawasaki's disease (KD).
  
  
  METHODS
  A retrospective study was performed on children one year of age or younger diagnosed from February 1992 to January 2006 with typical KD. Children with incomplete forms of the disease were not included.
  
  
  RESULTS
  Twenty-five infants were diagnosed with KD during the study period. The median age of the patients was 10 months (range, 4-12 months). All children but one received intravenous gammaglobulin (IVIG), 84% before the 10th day of disease. Seven patients (28%) required the administration of more than one dose of IVIG, because persistence of fever. Coronary artery disease (CAD) was recorded in 6 cases (24%), five of them being boys. All patients with CAD were treated with ASA plus IVIG and 84% of them received this therapy within the first 10 days of the KD onset.
  
  
  CONCLUSIONS
  In spite of the exclusion of our study of incomplete presentations and of an early administration of IVIG in our patients, we have observed a high rate of infants who developed CAD, which is similar to the one reported in children who do not receive IVIG.
authors.affiliation: Pediatric Infectious Diseases Unit, Children's Hospital La Paz, Madrid, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Moreno
authors.forename: Ana
authors.initials: A
authors.lastname: Méndez-Echevarría
authors.forename: Jaime
authors.initials: J
authors.lastname: de Inocencio
authors.forename: Fernando
authors.initials: F
authors.lastname: Del Castillo
authors.forename: Fernando
authors.initials: F
authors.lastname: Baquero-Artigao
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: García-Miguel
authors.forename: María Isabel
authors.initials: MI
authors.lastname: de José
authors.forename: Javier
authors.initials: J
authors.lastname: Aracil
mesh_terms: D002648:Child; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000209:etiology*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors