Lichen sclerosus: review of the literature and current recommendations for management.
OBJECTIVE
We reviewed the literature regarding the clinical presentation, etiology, natural history, and medical and surgical management of lichen sclerosus in men.


METHODS
We performed a comprehensive search of the literature in PubMed, MEDLINE and other electronic databases between 1950 and 2006 using the key words lichen sclerosis, balanitis xerotica obliterans and urethral stricture. Our search resulted in 1,268 sources containing the words lichen sclerosus or balanitis xerotica obliterans. We reviewed 68 articles in the peer reviewed journals and 2 chapters on this subject.


RESULTS
Lichen sclerosus is a chronic, lymphocyte mediated skin disease that was first described in 1887. It shows a predilection for the anogenital area in men and women. Much has been discovered regarding the epidemiology, natural history and histological features of this disease process during the last century, including the discovery of a strong association between lichen sclerosus and squamous cell carcinoma. The techniques of medical and surgical management of this disorder are still being elucidated. Biopsy of the initial lesion for definitive diagnosis and long-term followup of affected patients are well established, critical elements in the management of lichen sclerosus.


CONCLUSIONS
Lichen sclerosus is a chronic, debilitating condition that may progress to cause significant voiding complications. Biopsy is recommended in all patients suspected of having lichen sclerosus to rule out squamous cell carcinoma. Further research is needed to improve the prevention, understanding and treatment of this challenging condition.
Pugliese
Jennifer M
JM
Department of Surgery, Urology Service, Madigan Army Medical Center, Tacoma, Washington 98431, USA.
Morey
Allen F
AF
Peterson
Andrew C
AC
D001446:Balanitis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D017679:Cryotherapy / Q000379:methods; D005260:Female; D006801:Humans; D015994:Incidence; D053685:Laser Therapy / Q000379:methods; D018459:Lichen Sclerosus et Atrophicus / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D008297:Male; D011230:Precancerous Conditions / Q000473:pathology*; D011379:Prognosis; D018570:Risk Assessment; D017678:Sex Distribution; D016896:Treatment Outcome; D014525:Urethral Stricture / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D013520:Urologic Surgical Procedures / Q000379:methods; D007724:Vulvar Lichen Sclerosus / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*