[Polymorphism of the human platelet alloantigens HPA-3 and HPA-9w in the Chinese Han population].
OBJECTIVE
To study the polymorphism of human platelet alloantigens HPA-3 and HPA-9w in the Chinese Han population.


METHODS
A total of 1000 unrelated Chinese Han blood donors from different provinces of China were genotyped for HPA-3 and HPA-9w using PCR-sequence specific primer assay.


RESULTS
Gene frequencies of 1000 Chinese Hans for HPA-3a and HPA-3b were 0.5935 and 0.4065 respectively, and all of them were HPA-9a positive. The distributions of HPA-3, HPA-9w of Chinese Hans which detected by chi-square criterion fit Hardy-Weinberg equilibrium. There were significant differences of the HPA-3 alleles gene frequency between Guangdong province and other five investigated provinces which included Shanxi, Heilongjiang, Zhejiang, Yunnan and Jiangsu. In comparison to other ethnic groups, no significant differences were observed in the distributions of HPA-3 except the Vietnamese and Australian.


CONCLUSIONS
The results show that the chance of HPA-3 incompatibility were 0.3661 in random transfusion, and also provide a basis for researching on alloimmune thrombocytopenia and HPA-matched transfusion.
Huang
Hui
H
Shanghai Blood Center, Shanghai, 200051 P.R. China. fengmL@sh163.net.
Feng
Ming-liang
ML
Shen
Tong
T
Shen
Wei
W
Yin
Biao
B
Liu
Da-zhuang
DZ
D000483:Alleles; D016824:Antigens, Human Platelet / Q000235:genetics* / Q000276:immunology; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D004247:DNA / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006648:Histocompatibility / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic
D016824:Antigens, Human Platelet; D004247:DNA