The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America.
A previous study suggested that Helicobacter pylori strains possessing dupA are positively associated with duodenal ulceration and negatively associated with gastric adenocarcinoma. We determined the prevalence of dupA in H. pylori strains recovered from 4 independent populations and found a significant association with gastric cancer but not with duodenal ulceration.
Argent
Richard H
RH
Wolfson Digestive Diseases Centre, Queen's Medical Centre, Nottingham, United Kingdom. richard.argent@nottingham.ac.uk
Burette
Alain
A
Miendje Deyi
Véronique Y
VY
Atherton
John C
JC
D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D001530:Belgium / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D004381:Duodenal Ulcer / Q000453:epidemiology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D009656:North America / Q000453:epidemiology; D015995:Prevalence; D013019:South Africa / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000382:microbiology; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics / Q000502:physiology*
D001426:Bacterial Proteins; D037521:Virulence Factors