Cardiovascular disease in patients with spondyloarthropathies.
Spondyloarthropathies are associated with a greater cardiovascular risk than expected based on the cardiac lesions known to occur in these diseases. The prevalence of several conventional risk factors is high in spondyloarthropathy patients, and chronic inflammation also contributes to premature plaque formation. In addition, susceptibility genes for spondyloarthropathies may be associated with an increased risk of cardiovascular disease. Finally, several drugs used to treat spondyloarthropathies may contribute to the occurrence of cardiovascular events. A careful evaluation of the cardiovascular risk profile is a key component of the management of patients with spondyloarthropathies.
Vinsonneau
Ulric
U
Cardiology Department, Clermont Tonnerre Armed Forces Teaching Hospital, BP 41, 29240 Brest Armées, France. ulric.vinsonneau@wanadoo.fr
Brondex
Aurore
A
Mansourati
Jacques
J
Saraux
Alain
A
Cornily
Jean Christophe
JC
Arlès
Florence
F
Godon
Patrick
P
Quiniou
Gilles
G
D018501:Antirheumatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D050197:Atherosclerosis / Q000503:physiopathology; D054537:Atrioventricular Block / Q000453:epidemiology / Q000235:genetics; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000235:genetics; D006329:Heart Conduction System / Q000503:physiopathology; D006349:Heart Valve Diseases / Q000453:epidemiology; D006801:Humans; D007783:Lactones / Q000494:pharmacology / Q000627:therapeutic use; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D025242:Spondylarthropathies / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics; D013450:Sulfones / Q000494:pharmacology / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D018501:Antirheumatic Agents; D052246:Cyclooxygenase 2 Inhibitors; D015796:HLA-B27 Antigen; D007783:Lactones; D013450:Sulfones; D014409:Tumor Necrosis Factor-alpha; C116926:rofecoxib