[The relationship between resistin and the peripheral neuropathy in type 2 diabetes].
OBJECTIVE
To investigate the relationship between the serum resistin concentration and type 2 DM with peripheral neuropathy.


METHODS
Ninety-six patients of type 2 diabetes mellitus (DM) among which 52 were with peripheral neuropathy (DM + PN) and 34 healthy persons undergoing routine physical examination as controls were studied. Body weight, waist circumference, blood pressure, body mass index (BMI), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), and beta-cell action measured by the homeostasis model assessment (HOMA-beta), and blood lipids were measured. ELISA was used to detect the serum resistin, Endothelins (ET), and nitrogen oxide (NO).


RESULTS
The serum resistin level of the DM + PN patients was (26 +/- 9) ng/ml, significantly higher than that of the DM patients [(20 +/- 6) ng/ml, P < 0.05]. Th serum resistin level was positively correlated with FINS, Homa-IR, systolic blood pressure, diastolic blood pressure, and ET (all P < 0.05) and significantly negatively correlated with HOMA-beta and NO (both P < 0.05).


CONCLUSIONS
Resistin may play a role in the pathogenesis of type 2 DM and diabetic peripheral neuropathy.
Wang
Xiao-hong
XH
Deptment of Rehabilitation, Second Hospital of Shandong University, Jinan 250033, China.
Wang
Dao-qing
DQ
Chen
Shi-hong
SH
Zhang
Long
L
Ni
Yi-hong
YH
D000368:Aged; D001794:Blood Pressure; D016009:Chi-Square Distribution; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000097:blood* / Q000209:etiology; D052243:Resistin / Q000097:blood*
D008055:Lipids; D052243:Resistin