title: Primary bone marrow T-cell anaplastic large cell lymphoma with triple M gradient.
abstract: We present a case of a 60-year-old male patient with primary bone marrow anaplastic large cell lymphoma. He was admitted to the hospital with the symptoms of anemia and fever. There was no evidence of lymphadenopathy or splenomegaly. Immunoelectrophoresis showed the presence of a triple M gradient (double IgM and an IgG), with the IgG and one of the IgM paraproteins functioning as a cryoglobulin. The patient had no hepatitis C virus infection. Bone marrow biopsy showed massive CD30-positive, ALK-negative large lymphoid cell infiltration of T-cell origin with anaplastic morphology. PCR analysis of lymphoid cells separated from the bone marrow demonstrated the presence of a B/T hybrid genotype disorder with no evidence of the t(2;5), nor t(1;2) translocations. The patient entered a period of remission following CHOP chemotherapy. The patient subsequently died of sepsis as a consequence of serious humoral immunodeficiency.
authors.affiliation: 1st Department of Medicine, University of Pécs, Pécs, Hungary. aszomor@clinics.pote.hu
authors.forename: Arpád
authors.initials: A
authors.lastname: Szomor
authors.forename: Talal
authors.initials: T
authors.lastname: Al Saati
authors.forename: Georges
authors.initials: G
authors.lastname: Delsol
authors.forename: László
authors.initials: L
authors.lastname: Kereskai
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Szijártó
authors.forename: Hajna
authors.initials: H
authors.lastname: Losonczy
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M