title: Genetic study of Saudi diabetes (GSSD): significant association of the KCNJ11 E23K polymorphism with type 2 diabetes.
abstract: BACKGROUND
  The E23K variant of KCNJ11 has been associated with type 2 diabetes (T2D) in several but not all populations studied. Thus far, despite a high incidence of T2D, the role of this variant in Arabs has not been established.
  
  
  METHODS
  We performed a case-control association study using 550 T2D Saudi patients (WHO criteria), and 335 controls (age>or=60; fasting plasma glucose<7 mmol/L). E23K genotyping was performed by using molecular beacon-based real time PCR assays.
  
  
  RESULTS
  The difference in K or risk allele frequency of cases and controls was significant with an OR of 1.7 (p=0.0001). The K allele is more common among T2D patients (21%) than in the age and sex matched controls (13.6%). This was consistent with a likely eventual conversion to T2D of younger normoglycemic individuals as they grow older.
  
  
  CONCLUSIONS
  Our results report for the first time a positive association of the E23K variant with T2D in an Arab population. Confirmation by a larger study is indicated.
authors.affiliation: Arabian Diagnostic Laboratory (ADL), Research Centre, King Faisal Specialist Hospital and Research Centre, and Diabetes Center, King Abdulaziz University Hospital, Riyadh, Saudi Arabia. oalsmadi@kfshrc.edu.sa
authors.forename: Osama
authors.initials: O
authors.lastname: Alsmadi
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Rubeaan
authors.forename: Salma M
authors.initials: SM
authors.lastname: Wakil
authors.forename: Faiqa
authors.initials: F
authors.lastname: Imtiaz
authors.forename: Gamal
authors.initials: G
authors.lastname: Mohamed
authors.forename: Haya
authors.initials: H
authors.lastname: Al-Saud
authors.forename: Nouran Abu
authors.initials: NA
authors.lastname: Al-Saud
authors.forename: Nasser
authors.initials: N
authors.lastname: Aldaghri
authors.forename: Shahinaz
authors.initials: S
authors.lastname: Mohammad
authors.forename: Brian F
authors.initials: BF
authors.lastname: Meyer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018912:Arabs / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics*; D012044:Regression Analysis; D012529:Saudi Arabia / Q000453:epidemiology; D000099161:Kcnj11 Channel
chemical_list: D024661:Potassium Channels, Inwardly Rectifying; D000099161:Kcnj11 Channel