title: Cellulitis revealing a cryptococcosis-related immune reconstitution inflammatory syndrome in a renal allograft recipient.
abstract: Immune reconstitution inflammatory syndrome (IRIS) has rarely been described in the course of disseminated cryptococcosis in solid organ transplant recipients. We report here the case of a renal transplant recipient who developed severe cellulitis in the context of Cryptococcus neoformans-associated IRIS while undergoing reduction of his immunosuppressive therapy. IRIS appeared concomitantly with a dramatic increase of blood CD4+ T cells (94-460/mm(3)) and required the administration of a short-term steroid therapy to resolve.
authors.affiliation: Service des Maladies Infectieuses et Tropicales Hôpital Necker-Enfants Malades, Université Paris V Centre d'Infectiologie Necker-Pasteur, Paris, Cedex 15, France.
authors.forename: F
authors.initials: F
authors.lastname: Lanternier
authors.forename: M-O
authors.initials: MO
authors.lastname: Chandesris
authors.forename: S
authors.initials: S
authors.lastname: Poirée
authors.forename: M-E
authors.initials: ME
authors.lastname: Bougnoux
authors.forename: F
authors.initials: F
authors.lastname: Mechai
authors.forename: M-F
authors.initials: MF
authors.lastname: Mamzer-Bruneel
authors.forename: J-P
authors.initials: JP
authors.lastname: Viard
authors.forename: L
authors.initials: L
authors.lastname: Galmiche-Rolland
authors.forename: M
authors.initials: M
authors.lastname: Lecuit
authors.forename: O
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002481:Cellulitis / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology*; D003453:Cryptococcosis / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D003455:Cryptococcus neoformans / Q000276:immunology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: D000305:Adrenal Cortex Hormones; D000935:Antifungal Agents; D007166:Immunosuppressive Agents