title: The important role of lipid peroxidation processes in aging and age dependent diseases.
abstract: Any change in the cell membrane structure activates lipoxygenases (LOX). LOX transform polyunsaturated fatty acids (PUFAs) to lipidhydroperoxide molecules (LOOHs). When cells are severely wounded, this physiological process switches to a non-enzymatic lipid peroxidation (LPO) process producing LOO* radicals. These oxidize nearly all-biological molecules such as lipids, sugars, and proteins. The LOO* induced degradations proceed by transfer of the radicals from cell to cell like an infection. The chemical reactions induced by LO* and LOO* radicals seem to be responsible for aging and induction of age dependent diseases.Alternatively, LO* and LOO* radicals are generated by frying of fats and involve cholesterol-PUFA esters and thus induce atherogenesis. Plants and algae are exposed to LOO* radicals generating radiation. In order to remove LOO* radicals, plants and algae transform PUFAs to furan fatty acids, which are incorporated after consumption of vegetables into mammalian tissues where they act as excellent scavengers of LOO* and LO* radicals.
authors.affiliation: Organic Chemical Department, University of Bayreuth, Universitätsstrasse 30, Bayreuth, Germany. Gerhard.Spiteller@uni-bayreuth.de
authors.forename: Gerhard
authors.initials: G
authors.lastname: Spiteller
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000378:metabolism* / Q000517:prevention & control; D004032:Diet; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000378:metabolism*; D008084:Lipoxygenase / Q000378:metabolism; D012275:Oryza / Q000737:chemistry / Q000378:metabolism; D051381:Rats
chemical_list: D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; D008084:Lipoxygenase