title: Cellular genomic maps help dissect pathology in human skin disease.
abstract: Genomic signature maps of different cell types can aid in the interpretation of genomic data of specimens collected during disease states. We have defined "lineage-specific" genes, as well as "activation" genes, for cellular components of the skin: keratinocytes, fibroblasts, macrophages, monocytes, T cells, immature, and mature dendritic cells (DCs). Re-analysis of a previously published gene set of psoriasis then provided a model for assessing the usefulness of these maps. We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps.
authors.affiliation: Laboratory of Investigative Dermatology, The Rockefeller University, New York, New York 10021-6399, USA.
authors.forename: Asifa S
authors.initials: AS
authors.lastname: Haider
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Lowes
authors.forename: Mayte
authors.initials: M
authors.lastname: Suàrez-Fariñas
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Zaba
authors.forename: Irma
authors.initials: I
authors.lastname: Cardinale
authors.forename: Miroslav
authors.initials: M
authors.lastname: Blumenberg
authors.forename: James G
authors.initials: JG
authors.lastname: Krueger
mesh_terms: D001706:Biopsy; D019070:Cell Lineage / Q000502:physiology; D002874:Chromosome Mapping; D003713:Dendritic Cells / Q000473:pathology / Q000502:physiology; D005347:Fibroblasts / Q000473:pathology / Q000502:physiology; D023281:Genomics; D006801:Humans; D015603:Keratinocytes / Q000473:pathology / Q000502:physiology; D008264:Macrophages / Q000473:pathology / Q000502:physiology; D009000:Monocytes / Q000473:pathology / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis; D012867:Skin / Q000276:immunology / Q000473:pathology*; D012871:Skin Diseases / Q000235:genetics* / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology / Q000502:physiology