title: A novel and efficient synthesis of N,N-dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido oximes--potential marine fish toxin analogues. Part 1.
abstract: A novel and efficient method for the synthesis of N,N-dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido oximes (4) using activated silica as dehydrating agent has been developed. The reaction involves the condensation of substituted diacetyl monoxime and N,N-dialkylaminoisopropyl-phosphono hydrazide or O-alkylisopropylphosphono hydrazides and gave the corresponding analogues of a naturally occurring fish toxin in excellent yields under mild conditions.
authors.affiliation: Process Technology Development Division, Defence R and D Establishment, Jhansi Road, Gwalior 474002 (MP) India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Arvind K
authors.initials: AK
authors.lastname: Gupta
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Kaushik
mesh_terms: D000818:Animals; D005399:Fishes; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006835:Hydrazones; D008387:Marine Toxins; D009943:Organophosphorus Compounds; D010091:Oximes