DNA mimicry by proteins as effective mechanism for regulation of activity of DNA-dependent enzymes.
Modern concepts on mechanisms of DNA-dependent enzyme regulation involving specific DNA-mimicking proteins are considered. There are proteins that share structural resemblance with DNA duplexes. These include inhibitors of type I restriction-modification enzymes (Ocr and ArdA), inhibitors of DNA gyrase MfpA and QnrABS, etc. We describe here structural features of these proteins and mechanisms responsible for their interaction with DNA-dependent enzymes and then discuss perspectives of use of DNA-mimicking proteins in analysis of replication, repair, recombination, mechanisms underlying resistance to antibiotics, and also fields of applied biotechnology.
Zavilgelsky
G B
GB
State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow 117545, Russia. zavilgel@genetika.ru
Rastorguev
S M
SM
D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004262:DNA Restriction Enzymes / Q000378:metabolism; D018716:Molecular Mimicry; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D013379:Substrate Specificity
D011506:Proteins; D004247:DNA; D004262:DNA Restriction Enzymes