DMOAD developments: present and future.
Osteoarthritis (OA), by far the most common form of arthritis, has a growing impact on health care. Progress in understanding its pathophysiological processes has led to the identification of promising therapeutic targets, with disease-modifying osteoarthritis drugs (DMOADs) having the most potential. Numerous nonpharmaceutical measures and pharmacological interventions that slow the progression of the disease also have been developed. Several new classes of molecules that inhibit one or more OA pathophysiological processes have been discovered, and a number of these are under clinical evaluation to test their potential to alter the disease process in humans. Recent data from clinical trials have demonstrated that agents able to specifically block key disease mechanisms can effectively retard the progression of structural changes in knee OA patients. These studies are ushering the field into a new era in the development of DMOADs and, hence, the prospect of a cure for this disease.
Pelletier
Jean-Pierre
JP
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre-Dame Hospital, Quebec, Canada. dr@jppelletier.ca
Martel-Pelletier
Johanne
J
D000085:Acetates / Q000627:therapeutic use; D000880:Anthraquinones / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D002807:Chondroitin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004164:Diphosphonates / Q000627:therapeutic use; D018450:Disease Progression; D004318:Doxycycline / Q000627:therapeutic use; D005944:Glucosamine / Q000627:therapeutic use; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D061965:Matrix Metalloproteinase Inhibitors; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology*; D011758:Pyrroles / Q000627:therapeutic use; D012307:Risk Factors
D000085:Acetates; D000880:Anthraquinones; D018501:Antirheumatic Agents; D004164:Diphosphonates; D061965:Matrix Metalloproteinase Inhibitors; D011758:Pyrroles; C025292:diacerein; D006820:Hyaluronic Acid; D002807:Chondroitin; D005944:Glucosamine; D004318:Doxycycline; C088092:licofelone