title: Renin release.
abstract: The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located in the walls of renal afferent arterioles at the entrance of the glomerular capillary network. It has been known for a long time that renin synthesis and secretion are stimulated by the sympathetic nerves and the prostaglandins and are inhibited in negative feedback loops by angiotensin II, high blood pressure, salt, and volume overload. In contrast, the events controlling the function of renin-secreting cells at the organ and cellular level are markedly less clear and remain mysterious in certain aspects. The unravelling of these mysteries has led to new and interesting insights into the process of renin release.
authors.affiliation: Institute of Physiology, University of Regensburg, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Schweda
authors.forename: Ulla
authors.initials: U
authors.lastname: Friis
authors.forename: Charlotte
authors.initials: C
authors.lastname: Wagner
authors.forename: Ole
authors.initials: O
authors.lastname: Skott
authors.forename: Armin
authors.initials: A
authors.lastname: Kurtz
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D007606:Juxtaglomerular Apparatus / Q000166:cytology / Q000378:metabolism; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D019899:Paracrine Communication / Q000502:physiology; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D012083:Renin / Q000096:biosynthesis* / Q000378:metabolism*; D022142:Secretory Vesicles / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000242:Cyclic AMP; D012083:Renin