[Effect of cortex moutan on PGI2, TXA2, ET and NO in diabetic rats].
OBJECTIVE
To study the effect of Paeonol on PGI2, TXA2, ET and NO in diabetic rats.


METHODS
Streptozocin was used on rats to make diabetic animal models. Different dosage of Paeonol were used on diabetic animal models. PGI2, TXA2, ET and NO were tested after 30 days therapy.


RESULTS
Compared with those in the control group, the level of PGI2 increased and the contents of TXA2 and ET decreased in treatment group. Among them, the high dosage group was more obvious (P < 0.01). But the level of No Had no change.


CONCLUSIONS
Paeonol can decrease the ET and TXA2 in diabetic rats, and increase PGI2 in diabetic rats.
Min
Cun-Yun
CY
Guangdong Provincial People's Hospital, Guangzhou 510080, China.
Liu
He-Qiang
HQ
Zhan
Feng
F
Qiu
Wei-Zhong
WZ
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D016232:Endothelins / Q000097:blood; D011464:Epoprostenol / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D029596:Paeonia / Q000737:chemistry*; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D013928:Thromboxane A2 / Q000097:blood
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D016232:Endothelins; C038881:moutan cortex; D009569:Nitric Oxide; D013928:Thromboxane A2; D013311:Streptozocin; D011464:Epoprostenol