[Two cases of pyogenic spondylitis with chronic hepatitis C during combination therapy of interferon alfa and ribavirin].
This report describes our experience with two cases of pyogenic spondylitis with chronic hepatitis C during combination therapy of interferon alfa and ribavirin. The first patient, a 59-year-old man, was treated conservatively and improved, but the second patient, a 69-year-old woman, was not improved by conservative therapy and reconstructive operation was performed. The combination therapy of interferon alfa and ribavirin has a high risk of severe infectious diseases as side effects. CT scan and MRI are recommended immediately to diagnose pyogenic spondylitis, when patients has pyrexia and lumbago with laboratory data suspected inflammation during interferon therapy.
Sugahara
Kazuhiko
K
Department of Gastroenterology, Yamagata University School of Medicine.
Saito
Takafumi
T
Watanabe
Hisayoshi
H
Misawa
Keiko
K
Ishii
Rika
R
Suzuki
Akihiko
A
Haga
Hiroaki
H
Sanjo
Mai
M
Okumoto
Kazuo
K
Nishise
Yuko
Y
Ito
Junitsu
J
Saito
Koji
K
Togashi
Hitoshi
H
Kawata
Sumio
S
D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012254:Ribavirin / Q000009:adverse effects* / Q000627:therapeutic use; D013166:Spondylitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology / Q000601:surgery; D013203:Staphylococcal Infections; D013290:Streptococcal Infections; D013492:Suppuration; D016896:Treatment Outcome; D034363:Viridans Streptococci
D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin