Characterization of splenic CD21hi T2 B cells.
B cell development is a highly regulated process that initiates in the bone marrow (BM) of adult mice. After reaching the IgM+ immature stage in the BM, these B cells migrate to the spleen to complete maturation and incorporation into the long-lived peripheral lymphocyte pool. Studies have identified these splenic immature B cells, and have further attempted to delineate the sequence whereby they transition into mature B cells. As such, these immature splenic populations are termed transitional B cells and have been the focus of intense study. The review summarizes the phenotype and currently known functions of the four putative transitional B cell subsets identified to date. Although most appear to represent short-lived transitional B cells, the CD21hi T2 B cell population exhibits a number of qualities that question its label as a transitional B cell subset.
Verma
Shilpi
S
Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.
Waldschmidt
Thomas J
TJ
D019264:Adoptive Transfer; D000818:Animals; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology; D015551:Autoimmunity; D016175:B-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D007156:Immunologic Memory; D008221:Lymphoid Tissue / Q000276:immunology; D051379:Mice; D054448:Precursor Cells, B-Lymphoid / Q000166:cytology / Q000276:immunology*; D017464:Receptors, Complement 3d / Q000032:analysis* / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D000944:Antigens, Differentiation, B-Lymphocyte; D017464:Receptors, Complement 3d