title: [The relationship of P47phox C923T (Ala308Val) polymorphism to cerebral infarction and its effect on plasma lipid levels].
abstract: OBJECTIVE
  To investigate the relationship between C923T (Ala308Val) polymorphism in the exon10 of P47(phox) gene and cerebral infarction and to evaluate the effect of C923T polymorphism on plasma lipid levels.
  
  
  METHODS
  Peripheral blood samples were collected from 110 patients with cerebral infarction, 100 sex and age-matched healthy controls, and 102 members of 10 cerebral infarction pedigrees 19 of which were cerebral infarction patients. The polymorphism in P47(phox) gene was determined by PCR-single strand conformation polymorphism analysis and DNA sequencing. Plasma lipid levels were measured by routine methods.
  
  
  RESULTS
  Three gene types, CC, CT, and TT were found in the C923T (Ala308Val) polymorphism site. No statistically significant differences were found in the frequencies of genotypes and alleles of C923T polymorphism between the controls and cerebral infarction patients (all P > 0.05). The serum levels of triglyceride of cerebral infarction patients and controls with the CT genotype were markedly higher than those of the cerebral infarction patients and controls with the CC genotype (both P < 0.05).
  
  
  CONCLUSIONS
  There is no association between the C923T polymorphism and cerebral infarction. C923Tpolymorphism is associated with plasma lipid metabolism.
authors.affiliation: Department of Neuroloygy, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Xiao-song
authors.initials: XS
authors.lastname: Huang
authors.forename: Qi-dong
authors.initials: QD
authors.lastname: Yang
authors.forename: Xian-yu
authors.initials: XY
authors.lastname: Long
authors.forename: Yun-hai
authors.initials: YH
authors.lastname: Liu
authors.forename: Heng-fang
authors.initials: HF
authors.lastname: Liu
authors.forename: Qing-ping
authors.initials: QP
authors.lastname: Tang
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood; D001483:Base Sequence; D002544:Cerebral Infarction / Q000097:blood / Q000235:genetics / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019255:NADPH Oxidases / Q000235:genetics*; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D019255:NADPH Oxidases; C060505:neutrophil cytosolic factor 1