title: Thrombotic thrombocytopenic purpura and bone marrow necrosis as the initial presentation of lung cancer.
abstract: Thrombotic thrombocytopenic purpura (TTP) is a disseminated form of thrombotic microangiopathy. Although most cases are held to be idiopathic, its association with malignancy is well recognized, and it usually occurs at the terminal stage of cancer. Bone marrow necrosis (BMN) is another rare disorder defined pathologically as the necrosis of myeloid tissue and medullary stroma with preservation of bone. Although hematologic malignancy is the most common underlying disease associated with BMN, it can also be caused by solid tumors. The occurrence of TTP with BMN associated with lung cancer has not been reported in the English literature. First described is a patient with the rare association of TTP and BMN displayed as the first manifestations of a lung cancer.
authors.affiliation: Department of Medical Oncology, Gaziantep University, School of Medicine, Gaziantep Oncology Hospital, Gaziantep, TR-27310, Turkey. sevinc@gantep.edu.tr
authors.forename: Alper
authors.initials: A
authors.lastname: Sevinc
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Kalender
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Pehlivan
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sari
authors.forename: Celalettin
authors.initials: C
authors.lastname: Camci
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications*