Antiphospholipid syndrome and cognition.
In addition to the well-defined neurologic events due to arterial and venous thrombotic vascular occlusions of antiphospholipid syndrome (APS), a broad spectrum of neuropsychiatric has been related to antiphospholipid (aPL). Experimental evidence of a pathogenic role of aPL in mice with impaired neurological function disclosed inflammatory reaction as a hallmark. The process that leads to neurological dysfunction seems to be both structurally destructive and functionally impairing. The most modern resources of neuroimmaging also suggest that, in addition to the micro-infarcts that occur in strategic areas, other metabolic impairments are related to progressive dementia and aPL presence. Although there is a lot of confusion among APS and lupus' cognitive involvement, there is a body of experimental and clinical evidence that aPL causes this kind of damage.
Liberato
Bernardo
B
Neurology, Rede D'Or de Hospitais, Rio de Janeiro, Brazil.
Levy
Roger A
RA
D000818:Animals; D017152:Antibodies, Antiphospholipid; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000276:immunology / Q000503:physiopathology / Q000523:psychology*; D002544:Cerebral Infarction / Q000209:etiology / Q000276:immunology / Q000503:physiopathology / Q000523:psychology; D003071:Cognition; D005260:Female; D006801:Humans; D007249:Inflammation; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology / Q000503:physiopathology / Q000523:psychology; D051379:Mice; D011247:Pregnancy
D017152:Antibodies, Antiphospholipid