Control of beta globin genes.
The developmental changes in expression of the beta like genes from embryonic to adult stages of human life are controlled at least partially at the level of the promoter sequences of these genes and their binding factors, and competition for promoter specific interactions with the locus control region (LCR). In recent years, the control of beta globin genes has also been investigated at the level of chromatin structure involving the chemical modification of histones and their remodelling by DNA dependent ATPases (SMARCA) containing protein complexes. The role of intergenic RNA is also being investigated with renewed interest. Although a wealth of information on the structure/function relationship of the LCR and globin promoters has been gathered over more than two decades, the fundamental nature of the control of these genes at the molecular level is still not completely understood. In the following pages, we intend to briefly describe the progress made in the field and discuss future directions.
Mahajan
Milind C
MC
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Karmakar
Subhradip
S
Weissman
Sherman M
SM
D000818:Animals; D002843:Chromatin; D021901:DNA, Intergenic; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D005914:Globins / Q000235:genetics*; D006801:Humans; D019901:Locus Control Region
D002843:Chromatin; D021901:DNA, Intergenic; D005914:Globins