Evolution of some variable-number tandem repeat loci among a group of Beijing strains of Mycobacterium tuberculosis.
The patterns of variable-number tandem repeats (VNTR) genotypes of a clonal group of Mycobacterium tuberculosis Beijing isolates with very similar IS6110-restriction fragment length polymorphism (RFLP) patterns were studied. Differences between VNTR were mostly by a single repeat unit. However, a multiple-unit change also occurred. This suggests that a mechanism other than the slipped-strand mispairing might be responsible for the instability of VNTR in M. tuberculosis as well. This finding is useful for inferring phylogenetics of M. tuberculosis based on the VNTR genotypes.
Billamas
Pamaree
P
National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani, Thailand.
Smittipat
Nat
N
Juthayothin
Tada
T
Thong-On
Arunee
A
Yamada
Norio
N
Yanai
Hideki
H
Palittapongarnpim
Prasit
P
D019143:Evolution, Molecular; D005838:Genotype; D006801:Humans; D018598:Minisatellite Repeats / Q000235:genetics*; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D012150:Polymorphism, Restriction Fragment Length