Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains.
Huseby
Eric S
ES
Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, United States. husebye@njc.org
Kappler
John W
JW
Marrack
Philippa
P
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D022801:Complementarity Determining Regions / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000276:immunology*; D006801:Humans; D010455:Peptides / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*
D022801:Complementarity Determining Regions; D006649:Histocompatibility Antigens; D010455:Peptides; D016693:Receptors, Antigen, T-Cell, alpha-beta