title: Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis.
abstract: Lipodystrophy and metabolic abnormalities, primarily hypertriglyceridemia and insulin resistance, have been reported in juvenile dermatomyositis. We report a 55-year-old woman with adult dermatomyositis who developed lipodystrophy of the thighs, hypertriglyceridemia, and insulin resistance. Our case illustrates that lipodystrophy may occur in adult and juvenile dermatomyositis. Loss of subcutaneous tissue may be a cutaneous marker for metabolic abnormalities in both the adult and the juvenile forms of dermatomyositis.
authors.affiliation: Dermatology Division, Department of Medicine, Denver Health Medical Center, Denver, Colorado 80204, USA.
authors.forename: Lela A
authors.initials: LA
authors.lastname: Lee
authors.forename: Kathryn F
authors.initials: KF
authors.lastname: Hobbs
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003882:Dermatomyositis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology*; D007333:Insulin Resistance; D008060:Lipodystrophy / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D013848:Thigh
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D009173:Mycophenolic Acid; D011241:Prednisone