title: Adiponectin in severe preeclampsia.
abstract: OBJECTIVE
  Adiponectin is an adipokine with insulin-sensitizing, anti-atherogenic, anti-inflammatory and angiogenic properties. The aims of this study were to determine whether maternal plasma adiponectin concentrations differ between patients with severe preeclampsia and those with normal pregnancies, and to explore the relationship between plasma adiponectin and the results of Doppler velocimetry of the uterine arteries.
  
  
  METHODS
  This case-control study included two groups: (1) patients with severe preeclampsia (n=50) and (2) patients with normal pregnancies (n=150). Pulsed-wave and color Doppler ultrasound examination of the uterine arteries were performed. Plasma adiponectin concentrations were determined by ELISA. Non-parametric statistics were used for analysis.
  
  
  RESULTS
  (1) Patients with severe preeclampsia had a higher median plasma concentration of adiponectin than that of normal pregnant women. (2) The median plasma adiponectin concentration did not differ between women with severe preeclampsia who had a high impedance to blood flow in the uterine arteries and those with normal impedance to blood flow. (3) Among patients with normal pregnancies, plasma adiponectin concentrations were negatively correlated with BMI in the first trimester and at sampling.
  
  
  CONCLUSIONS
  Women with severe preeclampsia have a higher median plasma concentration of adiponectin than that of normal pregnant women. This may reflect a compensatory feedback mechanism to the metabolically-altered, anti-angiogenic and pro-atherogenic state of severe preeclampsia.
authors.affiliation: Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, USA.
authors.forename: Jyh Kae
authors.initials: JK
authors.lastname: Nien
authors.forename: Shali
authors.initials: S
authors.lastname: Mazaki-Tovi
authors.forename: Roberto
authors.initials: R
authors.lastname: Romero
authors.forename: Offer
authors.initials: O
authors.lastname: Erez
authors.forename: Juan Pedro
authors.initials: JP
authors.lastname: Kusanovic
authors.forename: Francesca
authors.initials: F
authors.lastname: Gotsch
authors.forename: Beth L
authors.initials: BL
authors.lastname: Pineles
authors.forename: Ricardo
authors.initials: R
authors.lastname: Gomez
authors.forename: Samuel
authors.initials: S
authors.lastname: Edwin
authors.forename: Moshe
authors.initials: M
authors.lastname: Mazor
authors.forename: Jimmy
authors.initials: J
authors.lastname: Espinoza
authors.forename: Bo Hyun
authors.initials: BH
authors.lastname: Yoon
authors.forename: Sonia S
authors.initials: SS
authors.lastname: Hassan
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012720:Severity of Illness Index; D018608:Ultrasonography, Doppler; D014599:Uterus / Q000098:blood supply* / Q000000981:diagnostic imaging*
chemical_list: D052242:Adiponectin