title: Confirmation of the efficacy of a novel formulation of metaflumizone plus amitraz for the treatment and control of fleas and ticks on dogs.
abstract: A novel spot-on formulation containing metaflumizone plus amitraz (ProMeris/ProMeris Duo for Dogs, Fort Dodge Animal Health, Overland Park, KS) was evaluated in four laboratory studies to confirm efficacy against fleas and ticks on dogs for 1 month. Three different strains of cat flea (Ctenocephalides felis felis) and four tick species were used. Rhipicephalus sanguineus and Dermacentor variabilis were evaluated concurrently in two studies and Ixodes scapularis and Amblyomma americanum in one study each. In all studies, dogs were randomly allocated to treatment groups and compared with nontreated dogs. One study also included a placebo treatment and a commercial product containing fipronil plus S-methoprene. All treatments were applied to the skin at a single spot between the scapulae on Day 0. Dogs were infested with fleas and/or ticks prior to treatment and then reinfested at weekly intervals for 6 weeks after treatment and evaluated for efficacy at 1 or 2 days after treatment and each reinfestation. These studies confirmed that treatment with ProMeris for Dogs at the proposed commercial dose rate rapidly controlled existing infestations of fleas and ticks on dogs. Treatment provided control of reinfesting fleas for up to 6 weeks and at least 4 weeks control of ticks. Efficacy was confirmed in a variety of dog breeds against three different flea strains and four common species of ticks found on dogs in the United States.
authors.affiliation: Fort Dodge Animal Health, P.O. Box 5366, Princeton, NJ 08543, USA. ruggd@pt.fdah.com
authors.forename: D
authors.initials: D
authors.lastname: Rugg
authors.forename: J A
authors.initials: JA
authors.lastname: Hair
authors.forename: R E
authors.initials: RE
authors.lastname: Everett
authors.forename: J R
authors.initials: JR
authors.lastname: Cunningham
authors.forename: L
authors.initials: L
authors.lastname: Carter
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004338:Drug Combinations; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007300:Insect Control / Q000379:methods / Q000592:standards; D007306:Insecticides; D026863:Ixodidae; D008297:Male; D012664:Semicarbazones; D005423:Siphonaptera; D013983:Tick Control / Q000379:methods / Q000592:standards; D013984:Tick Infestations / Q000188:drug therapy / Q000662:veterinary; D014052:Toluidines
chemical_list: D004338:Drug Combinations; D007306:Insecticides; D012664:Semicarbazones; D014052:Toluidines; C014983:amitraz; C528570:metaflumizone