Autism brain tissue banking.
One avenue of progress toward understanding the neurobiological basis of autism is through the detailed study of the post-mortem brain from affected individuals. The primary purpose of autism brain tissue banking is to make well-characterized and optimally preserved post-mortem brain tissue available to the neuroscience research community. In this paper we discuss our current understanding of the criteria for optimal characterization and preservation of post-mortem brain tissue; the pitfalls associated with inadequate clinical and neuropathological characterization and the advantages and disadvantages of post-mortem studies of the brain. We then describe the current status of the brain tissue bank supported by the Autism Tissue Program, including the demographic characteristics of the tissue donors, post-mortem interval, sex, age and the method of preservation. Finally, we provide information on the policies and procedures that govern the distribution of brain specimens by this bank and the nature of the studies that are currently being supported directly by this program.
Haroutunian
Vahram
V
Department of Psychiatry, The Mount Sinai School of Medicine, NY 10029-6574, USA. vahram.haroutunian@mssm.edu
Pickett
Jane
J
D017677:Age Distribution; D001321:Autistic Disorder / Q000473:pathology* / Q000503:physiopathology; D001921:Brain / Q000033:anatomy & histology / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D010336:Pathology / Q000592:standards / Q000639:trends*; D011180:Postmortem Changes; D017678:Sex Distribution; D014015:Tissue Banks / Q000592:standards* / Q000639:trends*; D014019:Tissue Donors / Q000706:statistics & numerical data; D016707:Tissue Fixation / Q000592:standards