title: [Tumor movements detected by multi-slice CT-based image fusion in the radiotherapy of lung cancer patients].
abstract: The aim of our study was to detect the possible uncertainties arising from tumor movements in the daily routine treatment planning, in extreme breathing conditions. Ten patients with lung cancer were enrolled into the study. According to tumor location, five patients had peripheral and five had central tumor. After the normal planning CT scan, two more scans were made with the same CT parameters in maximal exhalation and in maximal inhalation. For planning, the normal breathing scans were used with the fusion of the maximal inhalation and maximal exhalation scans. After the fusion in all breathing phases the gross tumor volumes were contoured (GTV1, GTV2, GTV3). Around the GTV1 (normal breathing phase GTV) 3 planning target volumes (PTV) were generated with the margin of 0.5 cm, 1.5 cm and 2.5 cm (PTV1, PTV2, PTV3). Individual plans were generated to all PTVs. All GTV volumes were registered. In all cases volume deviations were registered in different breathing phases (min: 1.5%, max: 35.6%). For GTV coverage comparison the coverage index (CI) was used. In case of extreme breathing conditions, using 0.5 cm margin was sufficient to reach good coverage for central tumors. For peripheral tumors 1.5 cm margin had to be used for the acceptable coverage (CI: 0.85-1.00). In our study, extreme breathing conditions were analyzed. According to our results, CT scans used in the daily routine do not exactly represent the tumor midposition and the true tumor volume. Due to breathing synchronous tumor movements, 0.5 cm margin must be used for planning in central location. In peripheral tumors wider margin should be used.
authors.affiliation: Egészségtudományi Centrum, Kaposvári Egyetem, Kaposvár, Hungary. kovacs.arpad@sic.hu
authors.forename: Arpád
authors.initials: A
authors.lastname: Kovács
authors.forename: Janaki
authors.initials: J
authors.lastname: Hadjiev
authors.forename: Ferenc
authors.initials: F
authors.lastname: Lakosi
authors.forename: Gergely
authors.initials: G
authors.lastname: Antal
authors.forename: Akos
authors.initials: A
authors.lastname: Horváth
authors.forename: Péter
authors.initials: P
authors.lastname: Bogner
authors.forename: Imre
authors.initials: I
authors.lastname: Repa
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000532:radiotherapy; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal; D012119:Respiration; D014057:Tomography, X-Ray Computed