title: [Histamine-2 receptor antagonist].
abstract: H. pylori infection and non-steroidal anti-inflammatory drugs (NSAIDs) are considered the two major causes of gastric mucosal lesions. Chronic administration of NSAIDs is associated with an increased incidence of significant adverse events such as upper gastrointestinal hemorrhage or perforation. The inhibition of prostaglandin synthesis, the decrease of gastric mucosal blood flow and the involvement of gastric acid are believed to be the mechanisms of NSAIDs-associated gastric mucosal lesions. In future, the significance of NSAIDs-associated gastric mucosal lesions may increase in Japan. Many studies have reported that proton pump inhibitor, high dosages of H2-RA, and prostaglandin analogs provide excellent prevention and therapeutic actions for NSAIDs-associated gastric ulcer. Additionally, recent studies have shown that regular dosages of H2-RA provide excellent prevention and therapeutic actions for NSAIDs-associated gastric mucosal lesions in Japan.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School.
authors.forename: Tomoari
authors.initials: T
authors.lastname: Kamada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kusunoki
authors.forename: Noriaki
authors.initials: N
authors.lastname: Manabe
authors.forename: Akiko
authors.initials: A
authors.lastname: Shiotani
authors.forename: Jiro
authors.initials: J
authors.lastname: Hata
authors.forename: Ken
authors.initials: K
authors.lastname: Haruma
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D017408:Guidelines as Topic; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006801:Humans; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006633:Histamine Antagonists