title: Bioactive constituents from Chinese natural medicines. XXVI. Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis.
abstract: The methanolic extract from the roots of Rhodiola sachalinensis was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the methanolic extract, five new glycosides, two monoterpene glycosides, two flavonol bisdesmosides, and a cyanogenic glycoside, were isolated together with 34 known compounds. The structures of new constituents were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal constituents, sachalosides III and IV, rhodiosin, and trans-caffeic acid, displayed hepatoprotective effects.
authors.affiliation: Kyoto Pharmaceutical University, Kyoto, Japan.
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Xuezheng
authors.initials: X
authors.lastname: Li
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Ninomiya
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.forename: Kikuji
authors.initials: K
authors.lastname: Yamaguti
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002478:Cells, Cultured; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008107:Liver Diseases / Q000517:prevention & control*; D009682:Magnetic Resonance Spectroscopy; D008518:Medicine, East Asian Traditional; D000432:Methanol / Q000737:chemistry; D051379:Mice; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D029771:Rhodiola / Q000737:chemistry*
chemical_list: D002109:Caffeic Acids; D005419:Flavonoids; D006027:Glycosides; D039821:Monoterpenes; D010936:Plant Extracts; C040048:caffeic acid; D000432:Methanol