title: The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease.
abstract: While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relationships between CSF measures of total tau (T-tau), hyperphosphorylated tau (P-tau 231), amyloid beta (Abeta42/Abeta40 ratio), and isoprostane (IP) with age and ApoE genotype. The results showed that age by epsilon4 genotype interactions were found for P-tau231 (beta=1.82; p<0.05) and IP (beta=1.6; p<0.05). T-tau CSF concentration increased with age. The increasing CSF concentrations of P-tau and IP in epsilon4 carriers suggest that early tauopathy and oxidative stress may be related to the increased risk for AD. The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study.
authors.affiliation: New York University School of Medicine, New York, NY 10016, United States.
authors.forename: Lidia
authors.initials: L
authors.lastname: Glodzik-Sobanska
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pirraglia
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Brys
authors.forename: Susan
authors.initials: S
authors.lastname: de Santi
authors.forename: Lisa
authors.initials: L
authors.lastname: Mosconi
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Rich
authors.forename: Remigiusz
authors.initials: R
authors.lastname: Switalski
authors.forename: Leslie
authors.initials: L
authors.lastname: Saint Louis
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Sadowski
authors.forename: Frank
authors.initials: F
authors.lastname: Martiniuk
authors.forename: Pankaj
authors.initials: P
authors.lastname: Mehta
authors.forename: Domenico
authors.initials: D
authors.lastname: Pratico
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Zinkowski
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.forename: Mony J
authors.initials: MJ
authors.lastname: de Leon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000235:genetics*; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000134:cerebrospinal fluid; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D015415:Biomarkers / Q000032:analysis / Q000134:cerebrospinal fluid; D004252:DNA Mutational Analysis; D015237:Dinoprost / Q000031:analogs & derivatives / Q000032:analysis / Q000134:cerebrospinal fluid; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000235:genetics; D010446:Peptide Fragments / Q000032:analysis / Q000134:cerebrospinal fluid; D010766:Phosphorylation; D011110:Polymorphism, Genetic / Q000235:genetics; D016875:tau Proteins / Q000032:analysis / Q000134:cerebrospinal fluid
chemical_list: C115626:8,12-iso-isoprostane F2alpha-VI; D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015415:Biomarkers; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D015237:Dinoprost