title: Antigenotoxic and free radical scavenging activities of extracts from Moricandia arvensis.
abstract: This study evaluates genotoxic and antigenotoxic effects of extracts from leaves of Moricandia arvensis, which are used in traditional cooking and medicines. Extracts showed no genotoxicity when tested with the SOS Chromotest using E. coli PQ37 and PQ35 strains, except for the total oligomers flavonoids enriched extract. Petroleum ether and methanol extracts are the most active in reducing nitrofurantoin genotoxicity, whereas methanol and total oligomers flavonoids enriched extracts showed the most important inhibitory effect of H2O2 genotoxicity. In addition, these two extracts showed important free radical scavenging activity toward the DPPH. radical, whereas the chloroform extract exhibited the highest value of TEAC against ABTS+. radical.
authors.affiliation: Unité de Pharmacognosie/Biologie Moléculaire 99/UR/07-03, Faculté de Pharmacie de Monastir, Monastir, Tunisia.
authors.forename: I
authors.initials: I
authors.lastname: Skandrani
authors.forename: M Ben
authors.initials: MB
authors.lastname: Sghaier
authors.forename: A
authors.initials: A
authors.lastname: Neffati
authors.forename: J
authors.initials: J
authors.lastname: Boubaker
authors.forename: I
authors.initials: I
authors.lastname: Bouhlel
authors.forename: S
authors.initials: S
authors.lastname: Kilani
authors.forename: A
authors.initials: A
authors.lastname: Mahmoud
authors.forename: K
authors.initials: K
authors.lastname: Ghedira
authors.forename: L
authors.initials: L
authors.lastname: Chekir-Ghedira
mesh_terms: D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles; D001713:Biphenyl Compounds / Q000737:chemistry; D019607:Brassicaceae / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D005609:Free Radicals / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry; D009152:Mutagenicity Tests; D010084:Oxidation-Reduction; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry
chemical_list: D016587:Antimutagenic Agents; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005609:Free Radicals; D006834:Hydrazines; D010851:Picrates; D010936:Plant Extracts; D013451:Sulfonic Acids; D013844:Thiazoles; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl