Influence of opiate addiction on liver cell damage of patients with viral hepatitis C.
Liver functional tests, cholestasis development and serum acute phase proteins, including a-1-proteinase inhibitor (PI) and albumin level (negative reactant of acute phase proteins), C-reactive protein (CRP) have been studied in the patients with viral hepatitis C (HCV) and/or drug addictive disorders (crude home-made opiates). Narcotic drugs were shown to be responsible for aggravation of cholestasis development in HCV patients with opiate addiction. Decreased albumin concentration in serum was registered in all groups with drug addictive disorders, as a result of modified acute phase reaction.
Korolenko
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TA
Institute of Physiology Siberian Branch of RAMS, Novosibirsk Municipal Infectious Hospital N 1, Novosibirsk Municipal Drug Addiction Center for Youth, Novosibirsk Medical University, Novosibirsk, Russia.
Goncharova
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Anterejkina
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Levina
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OA
Korolenko
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CP
D000209:Acute-Phase Proteins; D000293:Adolescent; D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects*; D002648:Child; D005260:Female; D006526:Hepatitis C / Q000150:complications*; D006596:Hexosaminidases; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008264:Macrophages; D008297:Male; D009293:Opioid-Related Disorders / Q000150:complications*; D010865:Pilot Projects
D000209:Acute-Phase Proteins; D000701:Analgesics, Opioid; D006596:Hexosaminidases; C086400:chitotriosidase