title: Dynamics of T-cell responses and memory T cells during primary simian immunodeficiency virus infection in cynomolgus macaques.
abstract: Cellular immune responses make an important contribution to both the control of human immunodeficiency virus (HIV) replication and disease progression. We used a pathogenic model of SIVmac251 infection of cynomolgus macaques to longitudinally evaluate cellular immune responses in association with various rates of disease progression. We found an inverse relationship between plasma viral load and the simian immunodeficiency virus (SIV)-specific T cells responses in peripheral blood and lymph nodes. SIV-specific T-cell responses in peripheral blood were transient during primary infection, with the highest responses detected around 3 months after infection. There was also a transient increase of central memory CD8(+) T cells in peripheral blood during primary infection, and effector memory T-cell counts in peripheral lymph nodes were increased. This study emphasizes the importance of the early virus-specific immune responses in the outcome of HIV/SIV disease and provides details about the changes of virus-specific immune responses over time.
authors.affiliation: CEA, Service d'Immuno-Virologie, DSV/iMETI, IPSC, Fontenay-aux-Roses, France.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Karlsson
authors.forename: Benoît
authors.initials: B
authors.lastname: Malleret
authors.forename: Patricia
authors.initials: P
authors.lastname: Brochard
authors.forename: Benoît
authors.initials: B
authors.lastname: Delache
authors.forename: Julien
authors.initials: J
authors.lastname: Calvo
authors.forename: Roger
authors.initials: R
authors.lastname: Le Grand
authors.forename: Bruno
authors.initials: B
authors.lastname: Vaslin
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D007156:Immunologic Memory; D008213:Lymphocyte Activation / Q000276:immunology*; D008252:Macaca fascicularis; D008297:Male; D012367:RNA, Viral / Q000097:blood; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer; D019562:Viral Load
chemical_list: D012367:RNA, Viral