title: Outcomes in patients with pulmonary hypertension undergoing percutaneous atrial septal defect closure.
abstract: OBJECTIVE
  To examine the outcomes in patients with moderate or severe pulmonary arterial hypertension (PAH) undergoing percutaneous atrial septal defect (ASD) closure.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Teaching hospital-based study.
  
  
  METHODS
  Fifty-four patients with moderate (n = 34) or severe PAH (n = 20) who underwent successful device implantation between 1999 and 2004 were included in the study. Clinical and transthoracic echocardiographic data were reviewed. Pulmonary hypertension was classified as moderate (50-59 mm Hg) or severe (>or=60 mm Hg) according with the right ventricular systolic pressure (RVSP) calculated by echocardiography.
  
  
  RESULTS
  At the early follow-up (mean (SD) 2.3 (1.2) months) all patients were alive and the baseline RVSP decreased from 57 (11) mm Hg to 51 (17) mm Hg (p = 0.003). At the late follow-up (n = 39, mean (SD) duration 31 (15) months) two patients had died and the baseline RVSP decreased from 58 (10) mm Hg to 44 (16) mm Hg (p = 0.004). Although the overall mean RVSP decreased at late follow-up, only 43.6% (17/39) of patients had normalisation (<40 mm Hg) of the RVSP and 15.4% (6/39) had persistent severe PAH.
  
  
  CONCLUSIONS
  Transcatheter closure in patients with secundum ASD and PAH can be successfully performed in selected subjects and is associated with good outcomes. Early improvements in RVSP are seen in patients with moderate or severe PAH undergoing transcatheter ASD closure. Continued improvement in RVSP occurs in late follow-up. Despite decreases in the mean RVSP in late follow-up, many patients do not have complete normalisation of pressures.
authors.affiliation: Toronto Congenital Cardiac Centre for Adults, University of Toronto, University Health Network, Toronto, Canada.
authors.forename: O H
authors.initials: OH
authors.lastname: Balint
authors.forename: A
authors.initials: A
authors.lastname: Samman
authors.forename: K
authors.initials: K
authors.lastname: Haberer
authors.forename: L
authors.initials: L
authors.lastname: Tobe
authors.forename: P
authors.initials: P
authors.lastname: McLaughlin
authors.forename: S C
authors.initials: SC
authors.lastname: Siu
authors.forename: E
authors.initials: E
authors.lastname: Horlick
authors.forename: J
authors.initials: J
authors.lastname: Granton
authors.forename: C K
authors.initials: CK
authors.lastname: Silversides
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D054087:Atrial Septum / Q000601:surgery*; D006328:Cardiac Catheterization; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006344:Heart Septal Defects, Atrial / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019919:Prosthesis Implantation / Q000379:methods*; D013599:Systole; D013995:Time; D016896:Treatment Outcome