title: Health implications of antimicrobial resistance for patients with acute kidney injury and bloodstream infection.
abstract: Studies have produced conflicting findings on outcomes for patients with antimicrobial-resistant infection. This study evaluated whether infection with an antimicrobial-resistant organism affects outcome in critically ill patients with acute kidney injury treated with renal replacement therapy and whose clinical course is complicated with a nosocomial bloodstream infection. We found that infection with an antimicrobial-resistant organism did not adversely affect clinical outcome in this specific cohort, which already has a high mortality rate.
authors.affiliation: Intensive Care Department, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Eric.Hoste@UGent.be
authors.forename: Eric A J
authors.initials: EA
authors.lastname: Hoste
authors.forename: Dominique M
authors.initials: DM
authors.lastname: Vandijck
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Vanholder
authors.forename: Jan J
authors.initials: JJ
authors.lastname: De Waele
authors.forename: Norbert H
authors.initials: NH
authors.lastname: Lameire
authors.forename: Stefaan
authors.initials: S
authors.lastname: Claus
authors.forename: Johan
authors.initials: J
authors.lastname: De Schuijmer
authors.forename: Annemieke W
authors.initials: AW
authors.lastname: Dhondt
authors.forename: Johan M A
authors.initials: JM
authors.lastname: Decruyenaere
authors.forename: Gerda
authors.initials: G
authors.lastname: Verschraegen
authors.forename: Stijn I
authors.initials: SI
authors.lastname: Blot
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000628:therapy; D000368:Aged; D016470:Bacteremia / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D001530:Belgium / Q000453:epidemiology; D015331:Cohort Studies; D003428:Cross Infection / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D017582:Renal Replacement Therapy