title: Substandard application of preimplantation genetic screening may interfere with its clinical success.
abstract: The intent of this study was to evaluate a recent randomized clinical trial evaluating the effect of preimplantation genetic screening (PGS) that reports a negative effect on pregnancy outcome. This article reviews appropriate PGS techniques and how they differ from the trial in question. A closer look at the clinical trial in question reveals significant lack of expertise in biopsy, cell fixation, genetic analysis, and patient selection. At most, this trial demonstrates that in inexperienced hands, PGS can be detrimental. No other conclusions concerning the effect of PGS on pregnancy results can be drawn from the trial.
authors.affiliation: Reprogenetics, Livingston, New Jersey 07039, USA. munne@reprogenetics.com
authors.forename: Santiago
authors.initials: S
authors.lastname: Munné
authors.forename: Luca
authors.initials: L
authors.lastname: Gianaroli
authors.forename: Ilan
authors.initials: I
authors.lastname: Tur-Kaspa
authors.forename: Cristina
authors.initials: C
authors.lastname: Magli
authors.forename: Mireia
authors.initials: M
authors.lastname: Sandalinas
authors.forename: Jamie
authors.initials: J
authors.lastname: Grifo
authors.forename: David
authors.initials: D
authors.lastname: Cram
authors.forename: Semra
authors.initials: S
authors.lastname: Kahraman
authors.forename: Yury
authors.initials: Y
authors.lastname: Verlinsky
authors.forename: Joe L
authors.initials: JL
authors.lastname: Simpson
mesh_terms: D000026:Abortion, Habitual / Q000628:therapy; D001706:Biopsy / Q000592:standards; D005260:Female; D005821:Genetic Techniques / Q000592:standards; D006801:Humans; D018579:Patient Selection; D011247:Pregnancy; D011256:Pregnancy Outcome; D019836:Preimplantation Diagnosis / Q000592:standards*; D016032:Randomized Controlled Trials as Topic / Q000592:standards