[Diagnostic accuracy of FP-CIT SPECT in patients with parkinsonism].
OBJECTIVE
To determine the diagnostic accuracy of FP-CIT SPECT in entities with and without presynaptic involvement of the nigral-striatal dopaminergic pathway in a large group of patients with movement disorders, evaluating the usefulness of quantitative analysis.


METHODS
A group of 183 consecutive patients clinically diagnosed as either having or not having degenerative Parkinsonism. These results were then contrasted with those of FP-CIT SPECT to determine the diagnostic accuracy of the procedure. The specific binding index was evaluated with ROC curves.


RESULTS
FP-CIT SPECT was highly accurate in the diagnosis of neurodegenerative Parkinsonism (sensitivity: 95 %, specificity: 90 %). Most of the false positive results arose in patients with vascular Parkinsonism and the false negative results in patients with Parkinson disease. ROC curve analysis of semiquantitative evaluation had a sensitivity of 83 % and specificity of 82 % with an optimal cut-off of 1.44. The area under the curve was not significantly different between patients </= 60 and > 60 years (0.899 vs 0.884) of age.


CONCLUSIONS
FP-CIT SPECT has a high degree of diagnostic accuracy for striatal dopaminergic involvement. No significant changes in diagnostic accuracy were seen with respect to patient age.
Ortega Lozano
S J
SJ
Servicio de Medicina Nuclear, Hospital Universitario Virgen de la Victoria, Málaga, España. simeon.ortega.sspa@juntadeandalucia.es
Martínez Del Valle Torres
M D
MD
Jiménez-Hoyuela García
J M
JM
Gutiérrez Cardo
A L
AL
Campos Arillo
V
V
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
D007457:Iodine Radioisotopes; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane