Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3-arylacrylonitriles as antifungal and anticancer agents.
A series of 3-aryl-2-(2-thienyl)acrylonitriles 7 and 3-aryl-2-(3-thienyl)acrylonitriles 8 were synthesized by the reaction of aromatic aldehydes 6 with 2- and 3-thienylacetonitriles 4 and 5, and evaluated for antifungal and cytotoxic activities against a panel of opportunistic and pathogenic fungi and three different cancer cell lines, respectively.
Quiroga
Jairo
J
Grupo de Investigación de Compuestos Heterocíclicos, Departamento de Química, Universidad del Valle, Cali, Colombia. jaiquir@univalle.edu.co
Cobo
Débora
D
Insuasty
Braulio
B
Abonía
Rodrigo
R
Nogueras
Manuel
M
Cobo
Justo
J
Vásquez
Yelkaira
Y
Gupta
Mahabir
M
Derita
Marcos
M
Zacchino
Susana
S
D000181:Acrylonitrile / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D015394:Molecular Structure
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000181:Acrylonitrile