Mollisianitrile, a new antibiotic from Mollisia sp. A59-96.
Mollisianitrile (1), a new antibiotic was isolated from the fermentation broth of Mollisa sp. A59-96 together with the two known isocoumarins 2 and 3. 1 exhibited antimicrobial, cytotoxic, and phytotoxic activities. 1 contains a reactive propiolonitrile moiety which is believed to be responsible for its antibiotic activities. Upon incubation with L-cysteine the biological activity was lost.
Weber
Daniela
D
a Institut für Biotechnologie und Wirkstoff-Forschung IBWF e.V., Erwin-Schrödinger-Strasse 56, D-67663 Kaiserslautern, Germany.
Sterner
Olov
O
Anke
Timm
T
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry* / Q000254:growth & development; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D005285:Fermentation; D018922:HL-60 Cells; D006801:Humans; D019169:Jurkat Cells; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000302:isolation & purification* / Q000494:pharmacology*; D012118:Resorcinols / Q000302:isolation & purification* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D009570:Nitriles; D012118:Resorcinols; C524683:mollisianitrile