[Correlation of expression of epidermal growth factor receptor-2 expression and tumor marker p53 in primary breast cancer].
OBJECTIVE
To observe the correlation between expression of epidermal growth factor receptor (HER)-2 and tumor marker p53 in breast cancer.


METHODS
specimens of primary breast cancer were collected from 2996l patients, all female, aged 50 (15 - 92). All of the cases were confirmed by pathohistological method. Immunohistochemistry was used to detect the expression of estrogen receptor (ER), progesterone receptor (PR), Her-2, and p53.


RESULTS
680 cases (22.7%) showed HER-2 overexpression, among which 378 cases (12.6%) were HER-2 weak positive (++) and 302 cases (10.1%) were HER-2 strong positive (+++). 935 cases were p53 positive and 2061 cases were p53 negative. The HER-2 overexpression rate was 32.3% in the p53-positive patients and 18.4% in the p53-negative patients. Expression of HER-2 was positively correlated with expression of p53 (P < 0.01).


CONCLUSIONS
Expression of p53 is the independent index of HER-2 expression, and there is a positive correlation between expression of HER-2 and expression of p53.
Liu
Peng
P
Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Liu
Yan
Y
Zhang
Jin
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D016009:Chi-Square Distribution; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D012044:Regression Analysis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53