title: One-pot syntheses, coordination, and characterization of application-specific biodegradable ligand-polymers.
abstract: Syntheses and chelation of tailored biodegradable polymers to rhenium for medicinal applications are described. A group of bifunctional ligand-initiators consisting of a chelating end for metal complexation and a hydroxyl end suitable to initiate polymerization was utilized in the ring-opening polymerization of l-lactide. The resulting biodegradable ligand-polymers were equipped with a tridentate donor set to coordinate specific metal ions. All synthesized compounds were characterized by IR spectroscopy, 1D/2D NMR spectroscopy and MALDI-TOF mass spectrometry, confirming successful polymerization and coordination to the [Re(CO)(3)](+) core. The pliability of designing application-specific polymers with respect to the nature of the metal ion facilitates extending the application of these biodegradable polymers to early detection of diseases (imaging) and radiotherapy of cancers.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, British Columbia V6T 1Z3, Canada.
authors.forename: Katayoun
authors.initials: K
authors.lastname: Saatchi
authors.forename: Urs O
authors.initials: UO
authors.lastname: Häfeli
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D019275:Radiopharmaceuticals; D012211:Rhenium / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D001672:Biocompatible Materials; D008024:Ligands; D009942:Organometallic Compounds; D011091:Polyesters; D011108:Polymers; D019275:Radiopharmaceuticals; D019344:Lactic Acid; C033616:poly(lactide); D012211:Rhenium