Persistent agmination of lymphomatoid papulosis: an equivalent of limited plaque mycosis fungoides type of cutaneous T-cell lymphoma.
BACKGROUND
Lymphomatoid papulosis (LyP) is a self-healing eruption in the spectrum of CD30+ lymphoproliferative disorders. The most common lymphoproliferative disorder associated with LyP is the most common form of cutaneous T-cell lymphoma: mycosis fungoides.


OBJECTIVE
We sought to describe a distinct entity on the spectrum of CD30+ lymphoproliferative disorders.


RESULTS
Seven patients presented with similar findings. Within a well-circumscribed area, the size and location of a patch of mycosis fungoides, these patients had continual eruptions of papulonodules that were histologically typical of LyP. The localized areas of involvement were treated as oligolesional mycosis fungoides and long-standing remissions occurred even after years of experiencing continuous localized eruptions. The clinical and histologic findings are reviewed and presented in a way to further the identification of patients with this entity.


CONCLUSIONS
This distinct entity is only defined by 7 patients.


CONCLUSIONS
The agmination of LyP-like papulonodules confined to a discrete circumscribed area is a distinct clinical subset within the spectrum of CD30+ lymphoproliferative disorders. The behavior of this entity is that of a progressive lymphoma that warrants therapy.
Heald
Peter
P
Yale Comprehensive Cancer Center, Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06519, USA. peter.heald@yale.edu
Subtil
Antonio
A
Breneman
Deborah
D
Wilson
Lynn D
LD
D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000096:biosynthesis; D016410:Lymphoma, T-Cell, Cutaneous / Q000209:etiology*; D017731:Lymphomatoid Papulosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000209:etiology*
D017730:Ki-1 Antigen