title: Contribution of molecular tools for the diagnosis of endogenous pneumococcal endophthalmitis in a patient with the acquired immunodeficiency syndrome.
abstract: Confirmation of infectious endophthalmitis is a major challenge. Traditional microbial tools are frequently unsuccessful mostly due to very small fluid samples and prior use of antibiotics. Here we report the first case of Streptococcus pneumoniae endophthalmitis diagnosed by polymerase chain reaction. Molecular biology should be considered as a new tool for the diagnosis of such sequestered sites as the eye.
authors.affiliation: Departments of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades Hospital, Paris, France. olivia.chandesris@nck.aphp.fr
authors.forename: Marie-Olivia
authors.initials: MO
authors.lastname: Chandesris
authors.forename: Arnaud
authors.initials: A
authors.lastname: Hot
authors.forename: Olivier
authors.initials: O
authors.lastname: Join-Lambert
authors.forename: Pierre
authors.initials: P
authors.lastname: Loulergue
authors.forename: Agnes
authors.initials: A
authors.lastname: Ferroni
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Viard
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D009877:Endophthalmitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D016133:Polymerase Chain Reaction
chemical_list: D000900:Anti-Bacterial Agents