title: Influence of radiofrequency catheter ablation on platelet aggregation.
abstract: The objective of this article was to find out how radiofrequency catheter ablation (RFA) influences platelet aggregation (PA), and the dependence on the total energy (TE) of RFA used and the cause of arrhythmia. We investigated 97 patients. PA was analyzed before, after, and in 24 hours after RFA. ADP- and epinephrine-induced PA significantly decreased after RFA by 5% and 8.9% (P < .001), respectively, and increased in 24 hours close to baseline. PA induced by ADP and collagen did not radically depend on the TE. Epinephrine-induced PA decreased after RFA by 0%, 8% (P < .05), and 16.9% (P < .01) in groups of patients where the TEs used were <4000 J, 4000 to 15,000 J, and >15,000 J, respectively. There were no significant differences in PA between groups based on the cause of arrhythmia. ADP- and epinephrine-induced PA significantly decreased after RFA and returned close to baseline in 24 hours. Epinephrine-induced PA was inversely associated with the TE used for RFA.
authors.affiliation: Institute of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania.
authors.forename: Vilma
authors.initials: V
authors.lastname: Kozlovaite
authors.forename: Pranas
authors.initials: P
authors.lastname: Grybauskas
authors.forename: Jurate
authors.initials: J
authors.lastname: Cimbolaityte
authors.forename: Ausra
authors.initials: A
authors.lastname: Mongirdiene
authors.forename: Aras
authors.initials: A
authors.lastname: Puodziukynas
authors.forename: Tomas
authors.initials: T
authors.lastname: Kazakevicius
authors.forename: Julius
authors.initials: J
authors.lastname: Ptasekas
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000097:blood* / Q000628:therapy*; D017115:Catheter Ablation / Q000009:adverse effects*; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D013923:Thromboembolism / Q000209:etiology
chemical_list: D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine