[11C]-dimethylamine as a labeling agent for PET biomarkers.
The dimethylamine functional group is a common component of the chemical structure of numerous drugs. The most commonly used synthetic route for carbon-11 labeled radiopharmaceuticals which contain the dimethylamine group is via C-11 methylation of the monomethyl amine precursors. Here we describe the radiosynthesis of [11C]dimethylamine (1) and its application in the direct labeling of several positron emission tomography (PET) imaging agents by-passing the preparation of the monomethyl amine precursors.
Jacobson
Orit
O
Department of Medical Biophysics and Nuclear Medicine, Hadassah Hebrew University, P.O.B. 12000, Jerusalem 91120, Israel.
Mishani
Eyal
E
D002250:Carbon Radioisotopes / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004123:Dimethylamines / Q000138:chemical synthesis / Q000302:isolation & purification; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000302:isolation & purification
D002250:Carbon Radioisotopes; D004123:Dimethylamines; D019275:Radiopharmaceuticals; C034516:dimethylamine