title: Synthesis of functionalized 1,2-dihydroisoquinolines via multicomponent one-pot reaction of 2-alkynylbenzaldehyde, amine, zinc, and allylic bromide or benzyl bromide.
abstract: A multicomponent one-pot reaction of 2-alkynylbenzaldehydes, amines, zinc, and allylic bromide or benzyl bromide using the combination of Mg(ClO4)2/Cu(OTf)2 as catalyst in THF/DCE (1:20) is described, which provides an efficient and practical route for the synthesis of functionalized 1,2-dihydroisoquinolines.
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Gao
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D000588:Amines / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry*; D001593:Benzyl Compounds / Q000737:chemistry*; D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
chemical_list: D000588:Amines; D001547:Benzaldehydes; D001593:Benzyl Compounds; C109853:G 1617; D006842:Hydrocarbons, Brominated; D007546:Isoquinolines; D015032:Zinc; C038682:benzyl bromide