title: Superior effect of a pi-acceptor ligand (phosphine-electron-deficient olefin ligand) in the Negishi coupling involving alkylzinc reagents.
abstract: Palladium-catalyzed Negishi cross-coupling involving primary and secondary alkyls, even in the presence of beta-H, can be achieved at ambient temperature using chelating ligands containing a phosphine and an electron-deficient olefin. The superior effects of the ligands were shown not only in the desired cross-coupling product yields but also in the fast reaction at mild conditions. This reaction has been also scaled up to 50 g in 0.005 mol % catalyst (20,000 TONs) at room temperature.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, PR China.
authors.forename: Xiancai
authors.initials: X
authors.lastname: Luo
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Duan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Lizheng
authors.initials: L
authors.lastname: Zhu
authors.forename: Tony
authors.initials: T
authors.lastname: Zhang
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei