Finishing mitosis, one step at a time.
The final stages of mitosis begin in anaphase, when the mitotic spindle segregates the duplicated chromosomes. Mitotic exit is then completed by disassembly of the spindle and packaging of chromosomes into daughter nuclei. The successful completion of mitosis requires that these events occur in a strict order. Two main mechanisms govern progression through late mitosis: dephosphorylation of cyclin-dependent kinase (Cdk) substrates and destruction of the substrates of the anaphase-promoting complex (APC). Here, we discuss the hypothesis that the order of late mitotic events depends, at least in part, on the order in which different Cdk and APC substrates are dephosphorylated or destroyed, respectively.
Sullivan
Matt
M
Department of Physiology, University of California, 600 16th Street, San Francisco, California 94158-2517, USA.
Morgan
David O
DO
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D016213:Cyclins / Q000378:metabolism; D006801:Humans; D008938:Mitosis; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010766:Phosphorylation; D013379:Substrate Specificity; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism
D016213:Cyclins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D010749:Phosphoprotein Phosphatases