title: N-trans-feruloyltyramine as a melanin biosynthesis inhibitor.
abstract: In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.
authors.affiliation: Department of Chemistry, Faculty of Engineering, Gifu University, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Efdi
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohguchi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Akao
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
authors.forename: Mamoru
authors.initials: M
authors.lastname: Koketsu
authors.forename: Hideharu
authors.initials: H
authors.lastname: Ishihara
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003373:Coumaric Acids / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D051379:Mice; D014442:Monophenol Monooxygenase / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D014439:Tyramine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D003373:Coumaric Acids; D008543:Melanins; D010936:Plant Extracts; C074004:feruloyltyramine; D014442:Monophenol Monooxygenase; D014439:Tyramine