Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy.
Eight d-ribo-phytosphingosine derivatives were synthesized from d-ribo-phytosphingosine and diverse acyl chlorides with N,N-diisopropylethylamine in tetrahydrofuran for 1h at room temperature. Effect of these compounds on IR-induced cell death was evaluated on blood cancer cells (Jurkat). Among these, 3d showed the highest enhancement of radiosensitizing effect.
Moon
Byung Seok
BS
Laboratory of Radiopharmaceuticals, Korea Institute of Radiological and Medical Sciences, 215-4 Gongneungdong, Nowongu, Seoul 139-706, Republic of Korea.
Park
Moon-Taek
MT
Park
Jeong Hoon
JH
Kim
Sang Wook
SW
Lee
Kyo Chul
KC
An
Gwang Il
GI
Yang
Seung Dae
SD
Chi
Dae Yoon
DY
Cheon
Gi Jeong
GJ
Lee
Su-Jae
SJ
D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D003131:Combined Modality Therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D019169:Jurkat Cells; D015458:Leukemia, T-Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use
D011838:Radiation-Sensitizing Agents; C012491:phytosphingosine; D013110:Sphingosine