Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population.
BACKGROUND
There is growing evidence that gallstone formation may be genetically determined. It was recently presented that a common polymorphism in the LRPAP1 gene might be associated with gallstone disease.


OBJECTIVE
Since reproducibility of data is important in genetic association studies, a case control study was designed to find out whether LRPAP1 gene polymorphism is associated with gallstone disease in a Polish population.


METHODS
Two hundred eighty-nine Polish Caucasian gallstone disease patients and 251 healthy controls participated in the study.


METHODS
A 37-bp insertion/deletion polymorphism in intron 5 of LRPAP1 (rs11267919) was determined by means of polymerase chain reaction assay.


RESULTS
The frequencies and distribution of the insertion/deletion alleles did not differ significantly between gallstone disease patients and controls. No significant gender-related differences in allele frequencies or distributions were noted.


CONCLUSIONS
The LRPAP1 insertion/deletion polymorphism is not associated with gallstone disease in a Polish population.
Juzyszyn
Z
Z
Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland.
Kurzawski
M
M
Modrzejewski
A
A
Sulikowski
T
T
Pawlik
A
A
Czerny
B
B
Droździk
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D042882:Gallstones / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D026563:LDL-Receptor Related Protein-Associated Protein / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011044:Poland; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
D026563:LDL-Receptor Related Protein-Associated Protein