title: Recombinant human zona pellucida protein C produced in Chinese hamster ovary cells binds to human spermatozoa and inhibits sperm-zona pellucida interaction.
abstract: Recombinant human zona pellucida protein C expressed in Chinese hamster ovary cells associates to the acrosomal region of human spermatozoa and inhibits sperm-zona pellucida interaction in the hemizona assay. Recombinant human zona pellucida protein C may be a useful tool toward the development of diagnostic methods for male factor infertility and the elucidation of the molecular basis of fertilization.
authors.affiliation: Instituto de Biología y Medicina Experimental, National Research Council of Argentina (CONICET), Buenos Aires, Argentina.
authors.forename: Clara I
authors.initials: CI
authors.lastname: Marín-Briggiler
authors.forename: María F
authors.initials: MF
authors.lastname: Gonzalez-Echeverría
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Harris
authors.forename: Mónica H
authors.initials: MH
authors.lastname: Vazquez-Levin
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D005306:Fertilization / Q000502:physiology*; D006801:Humans; D011485:Protein Binding; D011486:Protein C / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D015044:Zona Pellucida / Q000378:metabolism*
chemical_list: D011486:Protein C; D011994:Recombinant Proteins