Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro.
Antioxidants and plant products are reported to reduce the genotoxic damage of steroids. In our present study we have tested different dosages of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in the presence of S9 mix. Treatments with nordihydroguaiaretic acid (NDGA) results in the reduction of the genotoxic damage. A significant decrease was observed at all the tested doses of NDGA in sister chromatic exchanges of number of abnormal cells. The results suggest a protective role of NDGA against the genotoxic damage.
Siddique
Yasir Hasan
YH
Department of Zoology, Section of Genetics, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202 002, India. yasir_hasansiddique@rediffmail.com
Ara
Gulshan
G
Beg
Tanveer
T
Afzal
Mohammad
M
D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects; D003280:Contraceptives, Oral, Synthetic / Q000633:toxicity; D004249:DNA Damage / Q000187:drug effects*; D005040:Ethynodiol Diacetate / Q000633:toxicity*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D009637:Masoprocol / Q000494:pharmacology*; D009153:Mutagens / Q000633:toxicity*; D020011:Protective Agents / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects
D003280:Contraceptives, Oral, Synthetic; D009153:Mutagens; D020011:Protective Agents; D005040:Ethynodiol Diacetate; D009637:Masoprocol