[Transient myeloproliferative disorder in a neonate without Down syndrome].
We report a new case of transient myeloproliferative disorder (TMD) in a non Down syndrome neonate. The cytogenetic and molecular studies within from the blood blast cells identified a trisomy 21 and a partial deletion in exon 2 of the transcription factor GATA1. Spontaneous regression of the TMD was achieved at the age of 1 month as the clonal and molecular abnormalities. A survey by periodic cytological examinations of peripheral blood cells and GATA1 mutation analysis was instituted since three years and has not detected up to date acute leukaemia.
Adam
M
M
AP-HP, Services d'hématologie biologique et clinique, Hôpital d'enfants Armand Trousseau, Paris.
Vincenot
A
A
Gouraud
F
F
Harvel
C
C
Perot
C
C
Portnoi
M F
MF
Andre-Kerneis
E
E
Giraudier
S
S
Leverger
G
G
Favier
R
R
D004200:Diseases in Twins; D004314:Down Syndrome / Q000235:genetics; D005091:Exons / Q000235:genetics; D005500:Follow-Up Studies; D050982:GATA1 Transcription Factor / Q000235:genetics; D017353:Gene Deletion; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D008297:Male; D009154:Mutation / Q000235:genetics; D009196:Myeloproliferative Disorders / Q000175:diagnosis*; D012075:Remission, Spontaneous; D014429:Twins, Dizygotic
D050982:GATA1 Transcription Factor; C494688:GATA1 protein, human