Neonatal thrombocytosis following G-CSF treatment.
Thrombocytosis is defined as an elevation of the platelet count to more than 500,000/mm(3). Primary thrombocytosis rarely occurs in the pediatric age group and is usually caused by a clonal bone marrow disorder. The more common phenomenon is secondary thrombocytosis which is a reactive process. Table 1 lists the main causes of secondary thrombocytosis. Complications of severe thrombocytosis include bleeding and thromboses. Unless additional risk factors are present, secondary thrombocytosis is not associated with a significant risk of thromboembolic events, regardless of the degree of elevation of the platelet count. The aim of this case report is to add a new possible cause of neonatal thrombocytosis.
Osovsky
Micky
M
Department of Neonatology, Schneider Children's Medical Center of Israel, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. m_osovsky@yahho.com
Tamary
Hannah
H
Merlob
Paul
P
D001792:Blood Platelets / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D007970:Leukopenia / Q000188:drug therapy; D008297:Male; D009503:Neutropenia / Q000188:drug therapy; D013922:Thrombocytosis / Q000139:chemically induced* / Q000503:physiopathology
D016179:Granulocyte Colony-Stimulating Factor