title: Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis.
abstract: Against 447 anaerobe strains, the investigational carbapenem doripenem had an MIC 50 of 0.125 microg/ml and an MIC 90 of 1 microg/ml. Results were similar to those for imipenem, meropenem, and ertapenem. Time-kill studies showed that doripenem had very good bactericidal activity compared to other carbapenems, with 99.9% killing of 11 strains at 2x MIC after 48 h.
authors.affiliation: Department of Pathology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA.
authors.forename: Kim L
authors.initials: KL
authors.lastname: Credito
authors.forename: Lois M
authors.initials: LM
authors.lastname: Ednie
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000145:classification / Q000187:drug effects* / Q000254:growth & development*; D015780:Carbapenems / Q000494:pharmacology*; D015169:Colony Count, Microbial; D000077726:Doripenem; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000592:standards
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D000077726:Doripenem