title: Ethics of the early intervention in the treatment of schizophrenia.
abstract: When second generation antipsychotics were introduced in the mid 1990-s they offered the possibility of early psychopharmacological interventions in the treatment of schizophrenia. The idea applying antipsychotics in the prodromal phase of schizophrenia today is an realistic option. However ethical dilemmas about offering antipsychotics to the adolescents with at risk mental states, of whom only a few are real prodromes of schizophrenia remain for clinicians. In the literature about the ethics of the early interventions in psychiatry there are still many ethical questions which call for caution because of the low predictive value of at risk mental states, of which only 40% turn out to be a real prodrome of schizophrenia. These ethical questions can be addressed in three categories: - how to best identify who should receive early pharmacological intervention? - what this intervention should consist of? - how to evaluate treatment efficacy in the absence of illness base rates in the adolescents with a real prodrome of schizophrenia? Besides, arguing against the concept of early psychopharmacological interventions in the adolescent population are the fact of the unknown effect of antipsychotics on the developing brain as well as negative effects of stigma on those adolescents who receive them. The authors in the article analyse these ethical questions and take the side of those clinicians who think that caution and careful ethical judgment are needed before the prescribing of antipsychotics to adolescents with at risk mental states.
authors.affiliation: University Department of Psychiatry, Clinical Hospital Osijek, J.Huttlera 4, 31000 Osijek, Croatia. filakovic.pavo@kbo.hr
authors.forename: Pavo
authors.initials: P
authors.lastname: Filaković
authors.forename: Dunja
authors.initials: D
authors.lastname: Degmecić
authors.forename: Elvira
authors.initials: E
authors.lastname: Koić
authors.forename: Domagoj
authors.initials: D
authors.lastname: Benić
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D003219:Confidentiality / Q000941:ethics; D042241:Early Diagnosis; D004992:Ethics, Medical; D006801:Humans; D007258:Informed Consent / Q000941:ethics; D008134:Long-Term Care / Q000941:ethics; D011287:Prejudice; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents