The progesterone receptor PROGINS polymorphism is not related to oxidative stress factors in women with polycystic ovary syndrome.
BACKGROUND
Women with PCOS have been reported to be at increased risk of a number of gynaecological neoplasias, including endometrial, breast, and ovarian cancer. Studies of the possible association of genetic variation in progesterone receptor polymorphism with risk of ovarian and breast cancer have concentrated on a variant known as PROGINS.


METHODS
Ninety-five young women with PCOS and 99 healthy control women were included in our study. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, insulin and PROGINS polymorphism genetic study.


RESULTS
In PROGINS polymorphism results; in both control and the patient groups T1/T1 has been detected in high levels. But for genotype (p = 0.178) and allele (p = 0.555) frequencies both of the groups give similar results. Statistically significant difference has been detected on serum FSH levels for T1/T1 genotype according to T2/T2 genotype.


CONCLUSIONS
No relation has been detected between the inflammatory and oxidative stress factors, and PROGINS polymorphism alleles. This may be because the PCOS patients are young and their BMI means are normal and their CIMT and oxidative stress markers are like healthy women.
Karadeniz
Muammer
M
Division of Internal Disease, Department of Endocrinology and Metabolism, Ege University, Izmir, 35100, Turkey. muammerkaradenis@yahoo.com
Erdogan
Mehmet
M
Berdeli
Afig
A
Tamsel
Sadik
S
Saygili
Fusun
F
Yilmaz
Candeger
C
D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D018579:Patient Selection; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D011980:Receptors, Progesterone / Q000235:genetics*; D012016:Reference Values
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D011980:Receptors, Progesterone; D002097:C-Reactive Protein