title: Enhanced glycation of hemoglobin and plasma proteins is associated with increased lipid peroxide levels in non-diabetic hypertensive subjects.
abstract: BACKGROUND
  Accumulating evidences indicate that lipid peroxidation and protein glycation play a vital role in the pathogenesis of cardiovascular disease. The purpose of the present study was to evaluate the levels of lipid peroxides and glycated proteins in non-diabetic hypertensive patients and to assess the possible nexus between them, among these subjects.
  
  
  METHODS
  Thirty hypertensive patients and 25 normotensive subjects were enrolled in the present study. Lipid peroxides, glycated hemoglobin, and fructosamine levels were estimated in both groups.
  
  
  RESULTS
  Lipid peroxides, glycated hemoglobin, and fructosamine levels were significantly increased in hypertensive subjects in comparison with normotensive subjects. When partial correlation analysis was performed, malondialdehyde was significantly associated with glycated hemoglobin and fructosamine.
  
  
  CONCLUSIONS
  An increased glycation of proteins was found in non-diabetic hypertensive subjects. These data also support the premise that lipid peroxidation per se plays a role in glycation of hemoglobin and plasma proteins.
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Sathiyapriya
authors.forename: Nambiar
authors.initials: N
authors.lastname: Selvaraj
authors.forename: Hanumanthappa
authors.initials: H
authors.lastname: Nandeesha
authors.forename: Zachariah
authors.initials: Z
authors.lastname: Bobby
authors.forename: Aparna
authors.initials: A
authors.lastname: Agrawal
authors.forename: Purushothaman
authors.initials: P
authors.lastname: Pavithran
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000378:metabolism*; D016022:Case-Control Studies; D019270:Fructosamine / Q000097:blood; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006031:Glycosylation; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood* / Q000378:metabolism; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D019270:Fructosamine; D006442:Glycated Hemoglobin; D006454:Hemoglobins; D008054:Lipid Peroxides; D008315:Malondialdehyde; D017392:Thiobarbituric Acid Reactive Substances