title: FTO polymorphisms in oceanic populations.
abstract: It has been suggested that Neel's "thrifty genotype" model may account for high body weights in some Oceanic populations, which presumably arose in modern times. In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity. In this study, we investigated the population frequencies of these variants in six Oceanic populations (Melanesians, Micronesians, and Polynesians) and tested for an association with BMI. Unlike European populations, the Oceanic populations displayed no significant association between the FTO polymorphisms and BMI. These variants were in strong linkage disequilibrium. The population frequencies ranged between 4.2 and 30.3% in the six Oceanic populations, and were similar to those in southeast and east Asian populations. Our study of the FTO polymorphisms has generated no evidence to support the thrifty genotype hypothesis for Oceanic populations.
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. juno-tky@umin.ac.jp.
authors.forename: Jun
authors.initials: J
authors.lastname: Ohashi
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Naka
authors.affiliation: Department of Forensic Medicine, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kimura
authors.affiliation: School of Nursing, Fukuoka Prefectural University, Fukuoka, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Natsuhara
authors.affiliation: Department of Health Sciences, Hokkaido University School of Medicine, Hokkaido, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Yamauchi
authors.affiliation: ASNET Promotion Office, Division for International Relations, The University of Tokyo, Tokyo, Japan.
authors.forename: Takuro
authors.initials: T
authors.lastname: Furusawa
authors.affiliation: Department of Public Health, Graduate School of Medicine, Gunma University, Gunma, Japan.
authors.forename: Minato
authors.initials: M
authors.lastname: Nakazawa
authors.affiliation: School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ataka
authors.affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: Jintana
authors.initials: J
authors.lastname: Patarapotikul
authors.affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: Pornlada
authors.initials: P
authors.lastname: Nuchnoi
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.affiliation: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ishida
authors.affiliation: Department of Environmental Sociology, Faculty of Agriculture, Saga University, Saga, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Inaoka
authors.affiliation: Information Center, National Institute of Health and Nutrition, Tokyo, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsumura
authors.affiliation: National Institute for Environmental Studies, Ibaraki, Japan.
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Ohtsuka
mesh_terms: D000273:Adipose Tissue; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D044383:Black People / Q000235:genetics; D015992:Body Mass Index; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D009765:Obesity / Q000235:genetics*; D010139:Pacific Islands; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human