Hemophagocytic syndrome presenting with a facial erythema in a patient with systemic lupus erythematosus.
Hemophagocytic syndrome is a systemic reactive histiocytic proliferative disorder affecting the reticuloendothelial system. Skin lesions develop in 12.5% to 55.6% of the patients. We report a 35-year-old woman with systemic lupus erythematosus and Graves' disease complicated with parvovirus B19-associated hemophagocytic syndrome. She presented with slightly infiltrated erythematous macules and plaques with ulcers on the scalp, face, and back. A skin biopsy specimen taken from an area of facial erythema demonstrated typical phagocytic cells in the skin. Hemophagocytic syndrome-associated specific cutaneous lesions should be included in the differential diagnosis of facial and nonfacial erythema in patients with systemic lupus erythematosus.
Sakai
Hiroyuki
H
Department of Dermatology, Asahikawa City Hospital, Hokkaido, Japan. toko236@syd.odn.ne.jp
Otsubo
Sawa
S
Miura
Takanori
T
Iizuka
Hajime
H
D000328:Adult; D001415:Back; D003937:Diagnosis, Differential; D016731:Erythema Infectiosum / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D005145:Face; D005260:Female; D006111:Graves Disease / Q000150:complications; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000821:virology*; D012535:Scalp