High interleukin-10 production is associated with anti-acetylcholine receptor antibody production and treatment response in juvenile myasthenia gravis.
To investigate the significance of humoral immunological factors in juvenile myasthenia gravis (JMG) patients, 11 children with JMG (age of onset between 2 and 13 years) and 8 healthy controls were enrolled. Plasma IL-2, IL-10, IFN-gamma, TNF-alpha, complement factor C3, C4, and C1q levels were measured by ELISA. IL-2, IL-10, TNF-alpha, C3, and C4 levels were significantly elevated in the patient group. Moreover, plasma IL-10 levels were associated with the presence of anti-AChR antibody and response to treatment suggesting a critical role for IL-10 in JMG pathogenesis.
Yapici
Z
Z
Istanbul Medical Faculty, Department of Neurology Division of Child Neurology, Istanbul University, Capa, Istanbul, Turkey.
Tüzün
E
E
Altunayoğlu
V
V
Erdoğan
A
A
Eraksoy
M
M
D000906:Antibodies / Q000097:blood*; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D009157:Myasthenia Gravis / Q000097:blood / Q000276:immunology* / Q000628:therapy*; D011950:Receptors, Cholinergic / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D000906:Antibodies; D003176:Complement C3; D003181:Complement C4; D007376:Interleukin-2; D011950:Receptors, Cholinergic; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10