Functional delay of myelination of auditory delay lines in the nucleus laminaris of the barn owl.
In the barn owl, maps of interaural time difference (ITD) are created in the nucleus laminaris (NL) by interdigitating axons that act as delay lines. Adult delay line axons are myelinated, and this myelination is timely, coinciding with the attainment of adult head size, and stable ITD cues. The proximal portions of the axons become myelinated in late embryonic life, but the delay line portions of the axon in NL remain unmyelinated until the first postnatal week. Myelination of the delay lines peaks at the third week posthatch, and myelinating oligodendrocyte density approaches adult levels by one month, when the head reaches its adult width. Migration of oligodendrocyte progenitors into NL and the subsequent onset of myelination may be restricted by a glial barrier in late embryonic stages and the first posthatch week, since the loss of tenascin-C immunoreactivity in NL is correlated with oligodendrocyte progenitor migration into NL.
Cheng
Shih-Min
SM
Department of Biology, University of Maryland, College Park, MD 20742-4415, USA. chengsh@mail.nih.gov
Carr
Catherine E
CE
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D000831:Animals, Newborn; D001306:Auditory Pathways / Q000166:cytology / Q000502:physiology*; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D001933:Brain Stem / Q000166:cytology* / Q000196:embryology / Q000254:growth & development; D001973:Bromodeoxyuridine / Q000378:metabolism; D003463:Cues; D004625:Embryo, Nonmammalian; D005260:Female; D008297:Male; D008959:Models, Neurological; D009186:Myelin Sheath / Q000502:physiology* / Q000648:ultrastructure; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D009836:Oligodendroglia / Q000502:physiology / Q000648:ultrastructure; D013017:Sound Localization; D020305:Strigiformes / Q000033:anatomy & histology / Q000502:physiology*; D019063:Tenascin / Q000378:metabolism; D013997:Time Factors
D019063:Tenascin; D001973:Bromodeoxyuridine