Characterization of language and reading skills in familial polymicrogyria.
Polymicrogyria (PMG) is a malformation of cortical development characterized by an excessive number of small gyri and abnormal cortical lamination, giving the cortical surface an irregular and gross appearance. The severity of clinical manifestations correlates with the extent of cortical involvement. The objective of the present study was to describe three families with linguistic features of developmental language disorder and reading impairment, and to establish a neuroanatomic correlation through neuroimaging. Subjects have been submitted to a comprehensive protocol including psychological assessment, language evaluation, neurological examination, and neuroimaging investigation. In our families, children usually had the diagnosis of developmental language disorder while adults had the diagnosis of reading impairment. MRI showed perisylvian polymicrogyria in several subjects of each family. Our data support the idea that there is a co-occurrence of developmental language disorder and reading impairment and both conditions may be associated with polymicrogyria.
Oliveira
Ecila Paula Mesquita
EP
Department of Neurology, FCM/Unicamp, Campinas, SP, Brazil.
Hage
Simone Rocha Vasconcelos
SR
Guimarães
Catarina Abraão
CA
Brandão-Almeida
Iara
I
Lopes-Cendes
Iscia
I
Guerreiro
Carlos Alberto
CA
Teixeira
Karine Couto Sarmento
KC
Montenegro
Maria Augusta
MA
Cendes
Fernando
F
Guerreiro
Marilisa Mantovani
MM
D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000002:abnormalities*; D002648:Child; D004410:Dyslexia / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications* / Q000473:pathology*; D011446:Prospective Studies; D011932:Reading; D014888:Wechsler Scales