title: Relationship between self-association of glycine molecules in supersaturated solutions and solid state outcome.
abstract: Small angle x-ray scattering is utilized to directly examine the formation of clusters in supersaturated solutions of glycine, in an attempt to understand their role in the nucleation process. The results suggest that the majority of glycine molecules exist as dimers in aqueous solutions, and monomers in 13% (upsilon/upsilon) acetic acid-water mixtures. As the water and acetic acid-water solutions crystallize into alpha and gamma forms, respectively, the findings indicate a direct correlation between molecular self-association in solution and the polymorphic outcome.
authors.affiliation: Department of Chemical Engineering, Illinois Institute of Technology, Chicago, Illinois 60616, USA.
authors.forename: Deniz
authors.initials: D
authors.lastname: Erdemir
authors.forename: Soma
authors.initials: S
authors.lastname: Chattopadhyay
authors.forename: Liang
authors.initials: L
authors.lastname: Guo
authors.forename: Jan
authors.initials: J
authors.lastname: Ilavsky
authors.forename: Heinz
authors.initials: H
authors.lastname: Amenitsch
authors.forename: Carlo U
authors.initials: CU
authors.lastname: Segre
authors.forename: Allan S
authors.initials: AS
authors.lastname: Myerson
mesh_terms: D019342:Acetic Acid; D055592:Biophysical Phenomena; D001703:Biophysics; D003460:Crystallization; D019281:Dimerization; D005998:Glycine / Q000737:chemistry*; D053838:Scattering, Small Angle; D012996:Solutions; D014867:Water; D014961:X-Ray Diffraction
chemical_list: D012996:Solutions; D014867:Water; D019342:Acetic Acid; D005998:Glycine