[Cardiovascular responses to hypertonic NaCI injection into the anteroventral third ventricle region in rats with fructose-induced hypertension and insulin resistance].
OBJECTIVE
To investigate the hemodynamic sympathetic response evoked by NaCI microinjection into the third ventricle anteroventral brain area (AV3V) in rats long-term fed with high fructose diet.


METHODS
Twelve male rats received 60% fructose enriched diet for 6 months. Control rats (n=12) received regular diet.


RESULTS
Fructose diet increased (P< .01) body weight; plasma glucose, triglycerides; cholesterol, insulin; systolic (SBP) and diastolic blood pressure (DBP). Basal heart rate (HR) did not change. AV3V microinjection of 2 microL of hypertonic 1.5 M NaCI in fructose fed rats increased SBP 44.64(3.6) mm Hg, DBP 19.9(2.4) mm Hg and HR 66.2(8.4) beats/min over basal values (P< .01). In control rats, smaller responses were observed, SBP increased 28.33(3.10) mm Hg, DBP 13.0(1.9) mm Hg and HR 23.0(5.0) beats/min over basal values (P< .01).


CONCLUSIONS
Long-term fructose diet in rats induces cardiovascular hyperactivity of AV3V neurons to sodium chloride, and is associated to hypertension and insulin-resistance.
Rosa
Francisco J
FJ
Laboratorio de Estudios Cardiovasculares. Escuela de Medicina J.M. de Vargas, Facultad de Medicina, Universidad Central de Venezuela, San José, Caracas, Venezuela. frankrosa29@yahoo.com
Romero-Vecchione
Eduardo
E
Vásquez
José
J
Antequera
Rafael
R
Strauss
Miriam
M
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology*; D005632:Fructose / Q000008:administration & dosage; D006352:Heart Ventricles; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D006982:Hypertonic Solutions; D007267:Injections; D007333:Insulin Resistance; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000008:administration & dosage*
D006982:Hypertonic Solutions; D005632:Fructose; D012965:Sodium Chloride