title: A case of atypical canine lymphoma with oral mass and multiple osteolysis.
abstract: An 8-year-old female Golden Retriever had an oral mass and lameness. Multiple osteolysis of the systemic skeleton without monoclonal gammopathy was shown on electrophoresis of serum and urine samples. Cytological and histopathological examinations of the oral mass revealed atypical polymorphic cells similar to myeloid cells, and bone marrow aspiration indicated that these abnormal cells also might have invaded the bone marrow. These cells were negative to peroxidase and non-specific esterase staining, and clonal expansion of B lymphocytes could be detected by polymerase chain reaction (PCR) assay for antigen receptor gene rearrangement. The case was diagnosed as atypical lymphoma and treated by multi-drug chemotherapy. On the 142nd day after the first admission, the case had remission and the oral mass and multiple osteolysis were improved.
authors.affiliation: Veterinary Teaching Hospital, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ito
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hisasue
authors.forename: Sakurako
authors.initials: S
authors.lastname: Neo
authors.forename: Takefumi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Takuo
authors.initials: T
authors.lastname: Shida
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Enomoto
authors.forename: Masaru
authors.initials: M
authors.lastname: Okuda
authors.forename: Ryo
authors.initials: R
authors.lastname: Tsuchiya
authors.forename: Hiroo
authors.initials: H
authors.lastname: Madarame
authors.forename: Munetsugu
authors.initials: M
authors.lastname: Ogata
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamada
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000473:pathology; D002999:Clone Cells / Q000473:pathology; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D005260:Female; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010014:Osteolysis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*