title: Synthesis and evaluation of novel E-2-(2-thienyl)- and Z-2-(3-thienyl)-3-arylacrylonitriles as antifungal and anticancer agents.
abstract: A series of 3-aryl-2-(2-thienyl)acrylonitriles 7 and 3-aryl-2-(3-thienyl)acrylonitriles 8 were synthesized by the reaction of aromatic aldehydes 6 with 2- and 3-thienylacetonitriles 4 and 5, and evaluated for antifungal and cytotoxic activities against a panel of opportunistic and pathogenic fungi and three different cancer cell lines, respectively.
authors.affiliation: Grupo de Investigación de Compuestos Heterocíclicos, Departamento de Química, Universidad del Valle, Cali, Colombia. jaiquir@univalle.edu.co
authors.forename: Jairo
authors.initials: J
authors.lastname: Quiroga
authors.forename: Débora
authors.initials: D
authors.lastname: Cobo
authors.forename: Braulio
authors.initials: B
authors.lastname: Insuasty
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Abonía
authors.forename: Manuel
authors.initials: M
authors.lastname: Nogueras
authors.forename: Justo
authors.initials: J
authors.lastname: Cobo
authors.forename: Yelkaira
authors.initials: Y
authors.lastname: Vásquez
authors.forename: Mahabir
authors.initials: M
authors.lastname: Gupta
authors.forename: Marcos
authors.initials: M
authors.lastname: Derita
authors.forename: Susana
authors.initials: S
authors.lastname: Zacchino
mesh_terms: D000181:Acrylonitrile / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D015394:Molecular Structure
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000181:Acrylonitrile