title: Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae).
abstract: Antimalarial activity of anthothecol, a limonoid of Khaya anthotheca (Meliaceae) against Plasmodium falciparum was tested using a [(3)H]-hypoxanthine and 48h culture assay in vitro. Anthotechol showed potent antimalarial activity against malaria parasites with IC(50) values of 1.4 and 0.17microM using two different assays. Also, gedunin had antimalarial activity with IC(50) values of 3.1 and 0.14microM. However, the citrus limonoids, limonin and obacunone did not show any antimalarial activity. The antimalarial activities were compared with the three currently used antimalarial medicines quinine, chloroquinine and artemisinin.
authors.affiliation: Nanotoxtech. Inc., 301 Myung Jin Building, 234-27 Nonhyeon dong, Gangnam-gu, Seoul 153-010, Republic of Korea.
authors.forename: Sung-Eun
authors.initials: SE
authors.lastname: Lee
authors.forename: Mi-Ran
authors.initials: MR
authors.lastname: Kim
authors.forename: Jeong-Han
authors.initials: JH
authors.lastname: Kim
authors.forename: Gary R
authors.initials: GR
authors.lastname: Takeoka
authors.forename: Tae-Wan
authors.initials: TW
authors.lastname: Kim
authors.forename: Byeoung-Soo
authors.initials: BS
authors.lastname: Park
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D006801:Humans; D019271:Hypoxanthine; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D021241:Spectrometry, Mass, Electrospray Ionization; D014316:Tritium
chemical_list: D000962:Antimalarials; D036701:Limonins; D010936:Plant Extracts; C530481:anthothecol; D014316:Tritium; D019271:Hypoxanthine