Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?
Visceral leishmaniasis (VL) is a systemic protozoan disease that is transmitted by phlebotomine sandflies. Poor and neglected populations in East Africa and the Indian sub-continent are particularly affected. Early and accurate diagnosis and treatment remain key components of VL control. In addition to improved diagnostic tests, accurate and simple tests are needed to identify treatment failures. Miltefosine, paromomycin and liposomal amphotericin B are gradually replacing pentavalent antimonials and conventional amphotericin B as the preferred treatments in some regions, but in other areas these drugs are still being evaluated in both mono- and combination therapies. New diagnostic tools and new treatment strategies will only have an impact if they are made widely available to patients.
Chappuis
François
F
Travel and Migration Medicine Unit, Geneva University Hospitals, 24 rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland. francois.chappuis@hcuge.ch
Sundar
Shyam
S
Hailu
Asrat
A
Ghalib
Hashim
H
Rijal
Suman
S
Peeling
Rosanna W
RW
Alvar
Jorge
J
Boelaert
Marleen
M
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D003140:Communicable Disease Control / Q000379:methods*; D004359:Drug Therapy, Combination; D006801:Humans; D007893:Leishmania donovani / Q000502:physiology*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology
D000981:Antiprotozoal Agents