One gland, two lobes: organogenesis of the "Harderian" and "nictitans" glands of the Chinese muntjac (Muntiacus reevesi) and fallow deer (Dama dama).
The nictitans and Harderian glands are enigmatic glands situated in the anterior aspect of the orbit. Traditionally, the nictitans and Harderian glands of mammals have been considered to be two fundamentally distinct glands. However, a consistent, unambiguous distinction between these two glands has remained elusive due to conflicting anatomical and histochemical definitions. The Harderian gland was originally described, and first distinguished from the nictitans gland, in adult deer. We examined the organogenesis and histochemistry of the anterior orbital glandular mass in two species of deer (Muntiacus reevesi and Dama dama) to determine whether it comprises two distinct glands or one bilobed gland. The anterior orbital regions of 30 fetal specimens of both species, along with some adult material, were examined histologically. Four stages of glandular organogenesis were observed. Most notably, both glandular portions developed from the same inception point, but the deep lobe developed faster than the superficial lobe. The common inception point and the relationship of the collecting ducts clearly shows that this is a single glandular mass that differentiates into two lobes rather than two distinct glands. Moreover, although the histochemical profiles of the two lobes differ slightly, both lobes produce lipids, which is further indication that these are not profoundly different glands but part of a single, heterogeneously developed gland. Thus, it is proposed that the terms nictitans and Harderian glands, as separate entities, be discontinued and that the entire gland be referred to as the anterior orbital gland (glandula orbitalis anterior), with superficial and deep lobes (pars superficialis and pars profundus, respectively).
Rehorek
S J
SJ
Department of Biology, Slippery Rock University, Slippery Rock, PA 16057, USA. susan.rehorek@sru.edu
Hillenius
W J
WJ
Sanjur
J
J
Chapman
N G
NG
D000375:Aging; D000818:Animals; D003670:Deer / Q000033:anatomy & histology* / Q000196:embryology; D005123:Eye / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development; D006243:Harderian Gland / Q000033:anatomy & histology* / Q000196:embryology / Q000254:growth & development; D018668:Muntjacs / Q000033:anatomy & histology* / Q000196:embryology