title: Time scale of entropic segregation of flexible polymers in confinement: implications for chromosome segregation in filamentous bacteria.
abstract: We report molecular dynamics simulations of the segregation of two overlapping chains in cylindrical confinement. We find that the entropic repulsion between chains can be sufficiently strong to cause segregation on a time scale that is short compared to the one for diffusion. This result implies that entropic driving forces are sufficiently strong to cause rapid bacterial chromosome segregation.
authors.affiliation: FOM-Institute AMOLF, Kruislaan 407, 1098 SJ Amsterdam, The Netherlands. arnold@amolf.nl
authors.forename: Axel
authors.initials: A
authors.lastname: Arnold
authors.forename: Suckjoon
authors.initials: S
authors.lastname: Jun
mesh_terms: D017033:Anabaena / Q000166:cytology / Q000502:physiology; D001419:Bacteria / Q000145:classification* / Q000166:cytology; D020090:Chromosome Segregation; D002876:Chromosomes, Bacterial / Q000502:physiology*; D003198:Computer Simulation; D019277:Entropy; D008954:Models, Biological; D011108:Polymers / Q000737:chemistry*; D048372:Streptomyces coelicolor / Q000166:cytology / Q000502:physiology; D013997:Time Factors
chemical_list: D011108:Polymers