Phototriggers for nucleobases with improved photochemical properties.
Synthesis and photochemical properties of new photoremovable protecting groups for nucleobases are described. Four caged 2'-deoxycytidines (dCs) were synthesized, and their photochemical properties were measured under simulated physiological conditions. Two new coumarin-caged dCs show better photochemical and photophysical properties than those of the caged dCs having previously reported caging groups.
Furuta
Toshiaki
T
Department of Biomolecular Science and Research Center for Materials with Integrated Properties, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. furuta@biomol.sci.toho-u.ac.jp
Watanabe
Takayoshi
T
Tanabe
Satoshi
S
Sakyo
Jun
J
Matsuba
Chie
C
D002851:Chromatography, High Pressure Liquid; D003562:Cytidine / Q000737:chemistry; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D010777:Photochemistry
D009705:Nucleosides; D003562:Cytidine