A facile synthesis of cyclononatripyrroles.
A facile synthesis of a functionalized cyclononatripyrrole derivative is described. It involves the iodine-catalyzed cyclotrimerization of ethyl 3,3-dimethyl-5,7-dihydro[1,3]dioxepino[5,6-c]pyrrole-6-carboxylate in methanol. The product obtained in this way exists solely in the crown conformation typical of cyclononatripyrroles. However, in contrast to previously reported compounds of this class, it possesses three labile methoxymethyl arms that can be further functionalized under acidic conditions.
Stepień
Marcin
M
Department of Chemistry and Biochemistry, The University of Texas, 1 University Station A5300, Austin, TX 78712-0165, USA.
Sessler
Jonathan L
JL