Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones.
A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discovered either in the anti-proliferation test or in the HIV anti-integrase test.
Bailly
Fabrice
F
Laboratoire de Chimie Organique et Macromoléculaire, UMR CNRS 8009, Bâtiment C3, Université de Lille 1, 59655 Villeneuve d'Ascq Cedex, France.
Queffélec
Clémence
C
Mbemba
Gladys
G
Mouscadet
Jean-François
JF
Pommery
Nicole
N
Pommery
Jean
J
Hénichart
Jean-Pierre
JP
Cotelle
Philippe
P
D001483:Base Sequence; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D017931:DNA Primers; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology*; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
D017931:DNA Primers; D005663:Furans; D019428:HIV Integrase Inhibitors