title: Effect of the interaction between the fatty acid binding protein 2 gene Ala54Thr polymorphism and dietary fatty acids on peripheral insulin sensitivity: a cross-sectional study.
abstract: BACKGROUND
  The intestinal fatty acid-binding protein (FABP2) is involved in the intracellular transport and metabolism of fatty acids and may affect insulin sensitivity and glucose metabolism.
  
  
  OBJECTIVE
  The objective was to study the effect of interaction between the Ala54Thr polymorphism of the FABP2 gene (FABP2) and the type of dietary cooking oil used on peripheral insulin sensitivity in a population from southern Spain.
  
  
  METHODS
  The study was cross-sectional. Anthropometric measurements were obtained for 1226 persons aged 18-65 y selected randomly from the municipal census of Pizarra, Spain. An oral-glucose-tolerance test was given to 1020 of these persons. Insulin resistance was measured by homeostasis model assessment. Samples of the cooking oil being used were taken from the kitchens of a random subset of 538 persons.
  
  
  RESULTS
  Persons who consumed sunflower oil and who also had the Thr54 variant had higher insulin resistance than did those who consumed olive oil (P = 0.01). We detected an interaction between the Ala54Thr polymorphism and the type of oil consumed that accounted for the variance in insulin resistance (P = 0.02).
  
  
  CONCLUSIONS
  The effect of dietary fatty acids on the populational pattern of insulin resistance is not independent of the Ala54Thr polymorphism of FABP2. An interaction existed between this polymorphism and the intake of dietary fats in a population with a high intake of monounsaturated fatty acids.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Universitario Carlos Haya (Red de Diabetes y Metabolismo of the Instituto de Salud Carlos III, Madrid), Málaga, Spain. sonsoles.morcillo.exts@juntadeandalucia.es
authors.forename: Sonsoles
authors.initials: S
authors.lastname: Morcillo
authors.forename: Gemma
authors.initials: G
authors.lastname: Rojo-Martínez
authors.forename: Fernando
authors.initials: F
authors.lastname: Cardona
authors.forename: María de la Cruz
authors.initials: Mde L
authors.lastname: Almaraz
authors.forename: María de la Soledad Ruiz
authors.initials: Mde L
authors.lastname: de Adana
authors.forename: Isabel
authors.initials: I
authors.lastname: Esteva
authors.forename: Isabel
authors.initials: I
authors.lastname: Cardona
authors.forename: Federico
authors.initials: F
authors.lastname: Soriguer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003296:Cooking; D003430:Cross-Sectional Studies; D004042:Dietary Fats, Unsaturated / Q000378:metabolism / Q000494:pharmacology*; D050556:Fatty Acid-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D010938:Plant Oils / Q000378:metabolism / Q000494:pharmacology*; D011110:Polymorphism, Genetic; D013030:Spain; D000074242:Sunflower Oil
chemical_list: D001786:Blood Glucose; D004042:Dietary Fats, Unsaturated; C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins; D007328:Insulin; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil