Regulation of beta-cell mass and function by the Akt/protein kinase B signalling pathway.
The insulin receptor substrate-2/phosphoinositide 3-kinase (PI3K) pathway plays a critical role in the regulation of beta-cell mass and function, demonstrated both in vitro and in vivo. The serine threonine kinase Akt is one of the promising downstream molecules of this pathway that has been identified as a potential target to regulate function and induce proliferation and survival of beta cells. Here we summarize some of the molecular mechanisms, downstream signalling pathways and critical components involved in the regulation of beta-cell mass and function by Akt.
Elghazi
L
L
Department of Internal Medicine, Division of Endocrinology, Washington University School of Medicine, Metabolism & Lipid Research, St Louis, MO 63110, USA.
Rachdi
L
L
Weiss
A J
AJ
Cras-Méneur
C
C
Bernal-Mizrachi
E
E
D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000201:enzymology / Q000502:physiology*; D051379:Mice; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*
D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases; D020033:Protein Isoforms; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt