Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia.
Serglycin is the major cell-associated proteoglycan of hematopoietic cells. Previous work has demonstrated that serglycin may be involved in targeting some proteins to granules of cytotoxic lymphocytes, mast cells and neutrophils. We characterized the expression of serglycin in various hematologic malignancies by immunohistochemistry and ELISA. Serglycin expression was found to distinguish acute myeloid leukemia (AML) from acute lymphoblastic leukemia. In contrast to myeloperoxidase, serglycin was found to be a selective marker for immature myeloid cells, distinguishing AML from Philadelphia chromosome-negative chronic myeloproliferative disorders.
Niemann
C U
CU
Department of Hematology, Rigshospitalet, Copenhagen, Denmark. niemann@dadlnet.dk
Kjeldsen
L
L
Ralfkiaer
E
E
Jensen
M K
MK
Borregaard
N
N
D014408:Biomarkers, Tumor / Q000032:analysis*; D001773:Blood Cells / Q000737:chemistry; D001854:Bone Marrow Cells / Q000737:chemistry; D002454:Cell Differentiation; D003594:Cytoplasmic Granules / Q000737:chemistry; D003937:Diagnosis, Differential; D042381:Granulocyte Precursor Cells / Q000737:chemistry*; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000378:metabolism; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000378:metabolism; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000378:metabolism; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism; D009196:Myeloproliferative Disorders / Q000378:metabolism; D009363:Neoplasm Proteins / Q000032:analysis* / Q000097:blood; D009195:Peroxidase / Q000032:analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000378:metabolism; D011237:Predictive Value of Tests; D011509:Proteoglycans / Q000032:analysis* / Q000097:blood; D033921:Vesicular Transport Proteins / Q000032:analysis* / Q000097:blood
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D011509:Proteoglycans; D033921:Vesicular Transport Proteins; C075430:serglycin; D009195:Peroxidase