title: [Transient myeloproliferative disorder in a neonate without Down syndrome].
abstract: We report a new case of transient myeloproliferative disorder (TMD) in a non Down syndrome neonate. The cytogenetic and molecular studies within from the blood blast cells identified a trisomy 21 and a partial deletion in exon 2 of the transcription factor GATA1. Spontaneous regression of the TMD was achieved at the age of 1 month as the clonal and molecular abnormalities. A survey by periodic cytological examinations of peripheral blood cells and GATA1 mutation analysis was instituted since three years and has not detected up to date acute leukaemia.
authors.affiliation: AP-HP, Services d'hématologie biologique et clinique, Hôpital d'enfants Armand Trousseau, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Adam
authors.forename: A
authors.initials: A
authors.lastname: Vincenot
authors.forename: F
authors.initials: F
authors.lastname: Gouraud
authors.forename: C
authors.initials: C
authors.lastname: Harvel
authors.forename: C
authors.initials: C
authors.lastname: Perot
authors.forename: M F
authors.initials: MF
authors.lastname: Portnoi
authors.forename: E
authors.initials: E
authors.lastname: Andre-Kerneis
authors.forename: S
authors.initials: S
authors.lastname: Giraudier
authors.forename: G
authors.initials: G
authors.lastname: Leverger
authors.forename: R
authors.initials: R
authors.lastname: Favier
mesh_terms: D004200:Diseases in Twins; D004314:Down Syndrome / Q000235:genetics; D005091:Exons / Q000235:genetics; D005500:Follow-Up Studies; D050982:GATA1 Transcription Factor / Q000235:genetics; D017353:Gene Deletion; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D008297:Male; D009154:Mutation / Q000235:genetics; D009196:Myeloproliferative Disorders / Q000175:diagnosis*; D012075:Remission, Spontaneous; D014429:Twins, Dizygotic
chemical_list: D050982:GATA1 Transcription Factor; C494688:GATA1 protein, human