Effects of aerobic exercise on metabolic syndrome improvement in response to weight reduction.
OBJECTIVE
The objective was to test effects of aerobic exercise training on metabolic syndrome (MetSyn) improvement in response to weight reduction.


METHODS
A total of 459 overweight and obese women (age, 49 +/- 9 years; BMI, 28 +/- 3 kg/m(2)) were recruited for a baseline examination to test the relationship between cardiorespiratory fitness and metabolic syndrome prevalence; among these, 67 subjects with MetSyn were treated with 14-week weight-loss programs, which included low-calorie diet and aerobic exercise. The MetSyn was defined according to the Examination Committee of Criteria for "Metabolic Syndrome" in Japan. Maximal oxygen uptake (Vo(2max)) during a maximal cycling test was measured as an index of cardiorespiratory fitness at baseline and after the intervention.


RESULTS
In the baseline examination, age- and BMI-adjusted odds ratios for MetSyn prevalence in the low, middle, and upper thirds of Vo(2max) were 1.0 (referent), 0.50 (95% confidence interval, 0.26 to 0.95), and 0.39 (95% confidence interval, 0.14 to 0.96), respectively (linear trend, p = 0.02). The adjusted odds ratios for MetSyn improvement in the two interventions with diet alone and diet plus exercise were 1.0 and 3.68 (95% confidence interval, 1.02 to 17.6; p = 0.04), respectively.


CONCLUSIONS
These results suggest that adding aerobic exercise training to a dietary weight-reduction program further improves MetSyn (adjusted odds ratio, 3.68) in obese women, compared with diet alone. Further studies on an association between Vo(2max) change and MetSyn improvement are needed.
Okura
Tomohiro
T
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan. okura@taiiku.tsukuba.ac.jp
Nakata
Yoshio
Y
Ohkawara
Kazunori
K
Numao
Shigeharu
S
Katayama
Yasutomi
Y
Matsuo
Tomoaki
T
Tanaka
Kiyoji
K
D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D015444:Exercise; D005260:Female; D006801:Humans; D007564:Japan; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000150:complications / Q000178:diet therapy / Q000628:therapy*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000178:diet therapy / Q000628:therapy*; D016896:Treatment Outcome; D015431:Weight Loss
D001786:Blood Glucose; D008055:Lipids