title: Functional outcomes following total laryngopharyngectomy.
abstract: BACKGROUND
  Despite increasing use of laryngeal preserving protocols, laryngopharyngectomy remains the gold standard treatment for locally advanced hypopharyngeal and upper oesophageal tumours and for salvage following failed chemoradiotherapy. Nevertheless, improved perioperative medical care and experience in reconstruction have reduced mortality and improved functional outcomes.
  
  
  METHODS
  All patients undergoing total laryngopharyngectomy between July 2001 and July 2006 were prospectively recorded in a head and neck database. Demographics and functional outcomes were recorded.
  
  
  RESULTS
  Eighteen patients underwent laryngopharyngectomies with 5 having failed chemoradiotherapy and 13 presented with locally advanced tumours. Patients were reconstructed using free jejunal interposition if the lower anastomosis was in the neck (50%). They developed early fistulas (33%), late strictures (33%) and 44% spoke with a tracheo-oesophageal puncture, the rest with an electrolarynx. If the lower anastomosis was below the manubrium, patients required a gastric pull-up (38.9%). Gastric pull-up patients had fewer fistulas but more number of chest complications. More gastric pull-up patients tolerated solid diet and 43% managed oesophageal speech, the remainder using an electrolarynx. Overall, 88.9% of jejunums and 100% of gastric pull-ups tolerated oral alimentation and 100% used verbal communication. During a mean follow up of 34 months, 7 patients (38.9%) died; four patients died of local recurrence, two of distant metastases and one of unrelated causes.
  
  
  CONCLUSIONS
  Surgical treatment of neoplasms of the hypopharynx and cervical oesophagus is technically demanding and involves careful postoperative care to manage complications. Despite having a poor tumour-related prognosis, laryngopharyngectomy may be carried out in selected patients with low mortality and acceptable functional and survival results.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, St Vincent's Hospital, Melbourne, Victoria, Australia. iselitim@hotmail.com
authors.forename: Tim A
authors.initials: TA
authors.lastname: Iseli
authors.forename: Nicholas J M
authors.initials: NJ
authors.lastname: Agar
authors.forename: Catherine
authors.initials: C
authors.lastname: Dunemann
authors.forename: Bernard M
authors.initials: BM
authors.lastname: Lyons
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D010611:Pharyngectomy / Q000379:methods*; D011183:Postoperative Complications; D019651:Plastic Surgery Procedures; D020127:Recovery of Function; D016896:Treatment Outcome