Uncovering the dark side of TNF.
In the early 1980s, in search of the cytokine that triggers disease- associated weight loss and lethal shock, Anthony Cerami and Bruce Beutler purified "cachectin." They soon found out that their malevolent cytokine already had another name-tumor necrosis factor (TNF)-and was being lauded as a potential antitumor agent.
Bashyam
Hema
H
hbashyam@rockefeller.edu
D000818:Animals; D002417:Cattle; D006801:Humans; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha