title: Influence of obesity on bone density in postmenopausal women.
abstract: OBJECTIVE
  To evaluate the influence of obesity, age, and years since menopause on bone density.
  
  
  METHODS
  A retrospective analysis of bone mineral density (BMD) obtained from 588 women, 41 to 60 years, previously menopaused (1-10 years before).
  
  
  RESULTS
  Positive influence of obesity was confirmed by the significant differences in BMD at lumbar spine, femoral neck (FN), and trochanter (TR) between the groups (p < 0.01). Age and years since menopause (YSM) were negatively correlated with BMD at all sites (p = 0.000). Comparing patients within 1 to < 6 YSM versus 6 to 10 YSM, BMD was higher in the former at LS and FN (p < 0.005), despite the higher BMI in the older group (p = 0.01). Obese patients had a lower prevalence of osteoporosis at LS and FN (p = 0.009). Regression analysis identified BMI as the strongest determinant of FN and TR BMD, while YSM was the strongest determinant of LS BMD.
  
  
  CONCLUSIONS
  The protective effect of obesity is overtaken by age and estradiol deficiency. We recommend that even obese postmenopausal women should be screened for osteoporosis.
authors.affiliation: Division of Endocrinology, Federal University of Rio de Janeiro, RJ. henysevalente@hotmail.com
authors.forename: Henyse G Valente da
authors.initials: HG
authors.lastname: Silva
authors.forename: Laura M C
authors.initials: LM
authors.lastname: Mendonça
authors.forename: Flávia L
authors.initials: FL
authors.lastname: Conceição
authors.forename: Silvia E V
authors.initials: SE
authors.lastname: Zahar
authors.forename: Maria Lucia F
authors.initials: ML
authors.lastname: Farias
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D017668:Age of Onset; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D001938:Brazil / Q000453:epidemiology; D005260:Female; D005272:Femur Neck / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000503:physiopathology; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology; D017698:Postmenopause / Q000502:physiology*; D015995:Prevalence; D012044:Regression Analysis; D012189:Retrospective Studies