title: Multicentric reticulohistiocytosis associated with ovarian cancer.
abstract: Multicentric reticulohistiocytosis (MR) is an uncommon disease characterized by joint and cutaneous manifestations. The diagnosis must be confirmed by histological evidence of typical histiocytes and multinucleated giant cells. Many conditions, including malignancy, have been described in association with MR. We herein report a female case of MR in whom partial improvement was obtained by steroid and low-dose methotrexate treatments. However, ovarian cancer was found and therefore a surgical resection and chemotherapy were performed. These treatments resulted in the complete resolution of the skin and joint symptoms. These findings support the close linkage between MR and malignancy and the efficacy of cytotoxic drugs for the treatment of MR.
authors.affiliation: Department of General Internal Medicine, NHO National Nagasaki Medical Center, Nagasaki, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kishikawa
authors.forename: Taichiro
authors.initials: T
authors.lastname: Miyashita
authors.forename: Emiko
authors.initials: E
authors.lastname: Fujiwara
authors.forename: Osamu
authors.initials: O
authors.lastname: Shimomura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yasuhi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Niino
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ito
authors.forename: Misato
authors.initials: M
authors.lastname: Amenomori
authors.forename: Hideaki
authors.initials: H
authors.lastname: Osumimoto
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Osumi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
mesh_terms: D015703:Antigens, CD / Q000096:biosynthesis; D015214:Antigens, Differentiation, Myelomonocytic / Q000096:biosynthesis; D005260:Female; D015726:Giant Cells / Q000378:metabolism; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008727:Methotrexate / Q000494:pharmacology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D010053:Ovary / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000175:diagnosis; D012867:Skin / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D008727:Methotrexate; C067980:CD68 antigen, human; D000097382:CD68 Molecule