[Neutrophils and immunity: is it innate or acquired?].
The neutrophil has long been considered a phagocytic cell with a short life-span whose major role is to destroy intruders to the body. Toll receptors and anti-infectious factors such as defensin, perforin and granzymes are newly discovered mechanisms used by neutrophils for the first line of defense against invaders. Moreover, subpopulations of neutrophils share specific functions like the synthesis of certain cytokines and chemokines, as well as the expression of immunoreceptors like the T cell receptor. A primary consequence of inflammation on neutrophils is a delay in their spontaneous programmed cell death. Hence, this multifunctional cell is also a necessary actor of the acquired immune response. Neutrophils have the capacity to degrade and process antigens as well as efficiently present antigenic peptides to lymphocytes. Neutrophil interactions with immune cells, in particular dendritic cells, lead to the formation of IL-12 and TNF-alpha deviating the immune response towards a Th1 phenotype. Thus, the neutrophil exhibits a cellular plasticity that explains its capacity to transdifferentiate depending on the local requirements of the immune response. The neutrophil is probably the most underappreciated immune cell among hematopoietic leukocytes, and many neutrophil functions remain to be unraveled.
Chakravarti
Arpita
A
Centre de recherche en rhumatologie et immunologie, Centre de recherche du CHUL, Département de Médecine, Université Laval, 2705, boulevard Laurier, Bureau T1-49, Sainte-Foy (Québec) G1V 4G2, Canada.
Allaeys
Isabelle
I
Poubelle
Patrice E
PE
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D017209:Apoptosis; D002454:Cell Differentiation; D016207:Cytokines / Q000494:pharmacology / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D018448:Models, Immunological; D009504:Neutrophils / Q000145:classification / Q000187:drug effects / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology
D016207:Cytokines; D011971:Receptors, Immunologic