title: Family history of asthma and atopy: in-depth analyses of the impact on asthma and wheeze in 7- to 8-year-old children.
abstract: OBJECTIVE
  Development of asthma in children is influenced by interactions between genetic and environmental factors. It is unclear whether paternal or maternal histories of disease confer different risks. Previous population-based studies have not stratified analyses by child gender and sensitization status. Our aim was to study in detail the hereditary component of childhood asthma.
  
  
  METHODS
  A population-based cohort of 3430 (97% of invited) 7- to 8-year-old school children participated in an expanded International Study of Asthma and Allergy in Childhood survey, and two thirds were skin-prick tested. Heredity was defined as a family history of (1) asthma and (2) atopy (allergic rhinitis or eczema). Multivariate analyses corrected for known risk factors for asthma.
  
  
  RESULTS
  At ages 7 to 8, prevalence of asthma was 5.3% among the children and 9.0% among the parents. In children without parental asthma or parental atopy, the prevalence of asthma was 2.8%. Corrected for parental asthma, parental atopy was a weak but significant risk factor. There were minor differences in the impact of parental disease between sensitized and nonsensitized children and between boys and girls.
  
  
  CONCLUSIONS
  As risk factors for childhood asthma, there were major differences between parental asthma and parental atopy. Sibling asthma was only a marker of parental disease. Interactions between parental disease and the child's allergic sensitization or gender were not statistically significant. Asthma in both parents conferred a multiplicative risk, whereas the effect of parental atopy was additive, however limited. Asthma and atopy, despite their causal relationship, are separate entities and could be inherited differently. This large, population-based, and well-characterized cohort study does not confirm parent-of-origin effects found in previous studies.
authors.affiliation: Obstructive Lung Disease in Northern Sweden Studies, Department of Medicine, Sunderby Central Hospital of Norrbotten, Luleå, Sweden. anders.bjerg@lung.umu.se
authors.forename: Anders
authors.initials: A
authors.lastname: Bjerg
authors.forename: Linnea
authors.initials: L
authors.lastname: Hedman
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Perzanowski
authors.forename: Thomas
authors.initials: T
authors.lastname: Platts-Mills
authors.forename: Bo
authors.initials: B
authors.lastname: Lundbäck
authors.forename: Eva
authors.initials: E
authors.lastname: Rönmark
mesh_terms: D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006306:Health Surveys; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010290:Parents; D015995:Prevalence; D012135:Respiratory Sounds / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D035781:Siblings; D012882:Skin Tests; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology