Relationship between cardiovagal modulation and psychotic state in patients with paranoid schizophrenia.
Disturbed autonomic nervous system (ANS) function in schizophrenia might contribute to increased cardiovascular mortality. We obtained heart rate variability indices from 40 unmedicated schizophrenic patients and 58 matched controls. Mainly we found that patients displaying stronger psychotic symptoms as assessed by the Brief Psychiatric Rating Scale exhibit more severe cardiac ANS disturbances compared with controls.
Bär
Karl-Jürgen
KJ
Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University, Jena, Germany. Karl-Juergen.Baer@med.uni-jena.de
Wernich
Kirsten
K
Boettger
Silke
S
Cordes
Joachim
J
Boettger
Michael Karl
MK
Löffler
Stefan
S
Kornischka
Jürgen
J
Agelink
Marcus-Willi
MW
D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001342:Autonomic Nervous System Diseases / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D011618:Psychotic Disorders / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D012563:Schizophrenia, Paranoid / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D014630:Vagus Nerve / Q000502:physiology*
D014150:Antipsychotic Agents