[Effect of local microapplication of serotoninergic drugs on membrane currents of Paracentrotus lividus early embryos].
It was shown that local application of agonists of the 3rd type receptors SR57277A and quipazine into the interblastomere cleft of Paracentrotus lividus embryos evoked specific membrane currents. At the same time, ligands of 5-HT3-receptors specifically affected the cleavage patterns of half-embryos, i.e., imitated or avoided the interblastomere signal. In the view of the data obtained, we discuss a more precise concept of protosynapse, where the distribution of membrane serotonin receptors is restricted to the period of blastomere formation during cleavage and localized in the area of interblastomere contact.
Shmukler
Iu B
IuB
Tosti
E
E
Silvestre
F
F
D000818:Animals; D001757:Blastomeres / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D003404:Creatinine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects*; D047328:Paracentrotus / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D011814:Quipazine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D058827:Serotonin 5-HT3 Receptor Agonists; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D046509:Tissue Culture Techniques
D004338:Drug Combinations; D058827:Serotonin 5-HT3 Receptor Agonists; D017366:Serotonin Receptor Agonists; C014050:creatinine sulfate, serotonin drug combination; D012701:Serotonin; D011814:Quipazine; D003404:Creatinine