title: On the use of high dose rate 192Ir and 169Yb sources with the MammoSite radiation therapy system.
abstract: Ample literature exists on the dose overestimation by commercially available treatment planning systems in MammoSite applications using high dose rate 192Ir sources for partial breast brachytherapy as monotherapy, due to their inability to predict the dose reduction caused by the radiographic contrast solution in the balloon catheter. In this work Monte Carlo simulation is used to verify the dose rate reduction in a balloon breast applicator which does not vary significantly with distance and it is 1.2% at the prescription distance for the reference simulated geometry of 10% diluted radiographic contrast media and 2.5 cm balloon radius. Based on these findings and the minimal hardening of the initially emitted photon spectrum for 192Ir, a simple analytical method is proposed and shown capable for correcting dosimetry planning in clinical applications. Simulations are also performed to assess the corresponding dose reduction in applications of balloon breast applicators using high dose rate 169Yb sources that have recently become available. Results yield a far more significant and distance dependent dose reduction for 169Yb (on the order of 20% at the prescription distance for the abovementioned reference simulation geometry). This dose reduction cannot be accounted for using simple analytical methods as for 192Ir due to the significant hardening of the initially emitted 169Yb photons within the diluted radiographic contrast media. Combined with results of previous works regarding the effect of altered scatter conditions (relative to treatment planning system assumptions) on breast treatment planning accuracy, which is more pronounced for 169Yb relative to 192Ir, these findings call for the amendment of dose treatment planning systems before using 169Yb high dose rate sources in balloon breast applicators.
authors.affiliation: Medical Physics Department, Medical School, University of Athens, 75 Mikras Asias, 11527, Athens, Greece. ppapagi@phys.uoa.gr
authors.forename: P
authors.initials: P
authors.lastname: Papagiannis
authors.forename: P
authors.initials: P
authors.lastname: Karaiskos
authors.forename: E
authors.initials: E
authors.lastname: Georgiou
authors.forename: D
authors.initials: D
authors.lastname: Baltas
authors.forename: G
authors.initials: G
authors.lastname: Lymperopoulou
authors.forename: E
authors.initials: E
authors.lastname: Pantelis
authors.forename: L
authors.initials: L
authors.lastname: Sakelliou
mesh_terms: D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D009010:Monte Carlo Method; D017785:Photons; D011868:Radioisotopes / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D014867:Water / Q000737:chemistry; D015018:Ytterbium / Q000528:radiation effects* / Q000627:therapeutic use*
chemical_list: D007496:Iridium Radioisotopes; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D014867:Water; D015018:Ytterbium