[Does youth mean vigorous and age, feeble biological repair mechanisms?].
All living creatures are subject to aging, but our understanding of what governs aging is limited. In the course of a lifetime, with the constant renewal of the organic substance of living creatures errors arise, e.g. in the formation, disposal, and reproduction of DNA, proteins and lipids or in the constant substitution of aging cells in the organs. These errors are recognized and generally counterbalanced by appropriate repair mechanisms. This process is obviously determined partly by environmental influences (e.g. UV radiation, oxidizing influences, thermal shock) and genetic factors (such as the significance of so-called survival genes and gene mutations). In this paper the authors both explain and test the hypothesis that the aging of organs and organisms is the consequence of and not the reason for a progressive weakening of the repair mechanisms throughout life.
Dichgans
J
J
Zentrum für Neurologie, Universitat Tübingen, Bei der Ochsenweide 6, 72076 Tübingen, Germany.
Schulz
J B
JB
D000367:Age Factors; D000375:Aging; D001921:Brain / Q000503:physiopathology*; D008959:Models, Neurological; D009416:Nerve Regeneration; D019636:Neurodegenerative Diseases / Q000503:physiopathology*