title: Sexual dependency of rat sciatic nerve fiber conduction velocity distributions.
abstract: Gender differences, either with the structural or through with hormones, dictate how the corresponding organ or organ system responses to physiological signals. Current study aims to investigate gender dependent differences in conduction related parameters of rat sciatic nerve. Compound action potentials (CAP) were recorded via suction electrode whereas the conduction velocity distributions (CVD) were performed using the method known as collision technique in the literature. Studied CAP parameters, namely conduction velocities (CV), area of the CAPs and time required to reach the maximum depolarization (TP) have been found significantly different for female and male rats. Detailed analyses have shown that sex dependent differences were more remarkable in the right leg responses of female and male rats. Additionally, CVDs indicate that the number of fibers having CVs between 5-30 m/s is much more in male right sciatic nerve trunk when compared to age matched female rats. The present study, for the first time clearly shows that shift in the contribution of nerve fibers to lower CVs is the main causal of the sex dependent differences seen in rat sciatic nerve fibers.
authors.affiliation: Department of Biophysics, Selcuk University Meram Medical Faculty, Konya, Turkey. ayaz72@yahoo.com
authors.forename: Murat
authors.initials: M
authors.lastname: Ayaz
authors.forename: Erhan
authors.initials: E
authors.lastname: Kiziltan
authors.forename: Seckin
authors.initials: S
authors.lastname: Tuncer
authors.forename: Nizamettin
authors.initials: N
authors.lastname: Dalkilic
authors.forename: Ilhami
authors.initials: I
authors.lastname: Demirel
authors.forename: Hulagu
authors.initials: H
authors.lastname: Bariskaner
authors.forename: Ferit
authors.initials: F
authors.lastname: Pehlivan
mesh_terms: D000200:Action Potentials; D000818:Animals; D005260:Female; D007839:Functional Laterality; D066298:In Vitro Techniques; D008297:Male; D009412:Nerve Fibers / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000502:physiology*; D012737:Sex Factors; D013997:Time Factors