title: A case of anorexia nervosa with Marchiafava-Bignami Disease that responded to high-dose intravenous corticosteroid administration.
abstract: We report the first known case of anorexia nervosa (AN) with Marchiafava-Bignami Disease (MBD) that responded to high-dose intravenous corticosteroid administration. A 16-year-old Japanese female with AN was diagnosed with MBD after rapid weight loss. During the acute stage, she suffered from a sudden onset of coma. After regaining consciousness, she presented with lack of movement, apathy, labile affect, and poverty of speech. On admission, magnetic resonance imaging showed an area of demyelination in the splenium of the corpus callosum. Positron emission tomography obtained 7 days after admission showed areas of hypoperfusion in the medial temporal lobe and in regions anterior and posterior to the central sulcus.
authors.affiliation: Department of Neuropsychiatry, Hokkaido University School of Medicine, Kita 14 Nishi 5, Kitaku, Sapporo, Hokkaido, Japan. hirokitao@aol.com
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tao
authors.forename: Nobuki
authors.initials: N
authors.lastname: Kitagawa
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kako
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Yamanaka
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
authors.forename: Kenzo
authors.initials: K
authors.lastname: Denda
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Koyama
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000150:complications* / Q000188:drug therapy; D003337:Corpus Callosum / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D005666:Fursultiamin / Q000008:administration & dosage*; D015600:Glasgow Coma Scale; D006801:Humans; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D054319:Marchiafava-Bignami Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D008775:Methylprednisolone / Q000008:administration & dosage*; D009460:Neurologic Examination / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D049268:Positron-Emission Tomography; D012039:Regional Blood Flow / Q000187:drug effects; D013702:Temporal Lobe / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D014803:Vitamin B Complex / Q000008:administration & dosage*
chemical_list: D018696:Neuroprotective Agents; D005666:Fursultiamin; D014803:Vitamin B Complex; D008775:Methylprednisolone