The interaction between selenium status, sex hormones, and thyroid metabolism in adolescent girls in the luteal phase of their menstrual cycle.
The objective of the present work was to study all physiological relationships among selenium status (SeS), sex hormones secretion (SH), and thyroid metabolism (ThM) in healthy adolescent girls, at one time. Forty-four girls aged 13.4-16.6 years (mean age, 14.5 +/- 0.5 years) entered the statistical model. Parameters reflecting SeS: plasma selenium concentration (Se) and plasma glutathione peroxidase activity (GPX3); SH: serum estradiol (E2) and progesterone (P4); age of menarche (AoM); and ThM: thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), antithyroid peroxidase antibodies (anti-TPO) in serum, and thyroid volume (ThV), were determined, and the interactions between them were evaluated by means of the partial least squares method (PLS). PLS method was, for the first time, successfully applied to the problem of selenium and hormone interactions and revealed that selenium status and female reproductive system are interrelated and affect thyroid physiology in adolescent girls in the luteal phase. The strongest associations were revealed for the pairs of parameters, Se and fT4/fT3, Se and P4, the modest ones for the pairs, Se and ThV, P4 and fT4/fT3, Se and AoM, and P4 and AoM. There was no correlation between E2, GPX3, and TSH, and any other considered parameter. Se and P4 had the greatest influence on ThM parameters.
Zagrodzki
Paweł
P
Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Kraków, Poland. Pawel.Zagrodzki@ifj.edu.pl
Ratajczak
Ryszard
R
Wietecha-Posłuszny
Renata
R
D000293:Adolescent; D004958:Estradiol / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D008183:Luteal Phase / Q000502:physiology*; D011374:Progesterone / Q000097:blood; D012643:Selenium / Q000378:metabolism*; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood
D012739:Gonadal Steroid Hormones; D011374:Progesterone; D004958:Estradiol; D013972:Thyrotropin; D012643:Selenium