Metabolism of benzo[a]pyrene in peroxynitrite/Fe(III) porphyrin system.
The peroxynitrite/porphyrin biomimetic system was established to investigate the effects of peroxynitrite on benzo[a]pyrene (B[a]P) metabolism. Three model systems consisting of different iron porphyrins were compared, and the results showed that the peroxynitrite/T(p-Cl)PPFeCl system was the highest catalytic efficiency in the metabolism of B[a]P. We analyzed the B[a]P metabolites produced from this system by RP-HPLC method and firstly identified the formation of nitrobenzo[a]pyrenes which are the special metabolites of B[a]P induced by peroxynitrite.
Luo
Yun-jing
YJ
College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China. luoyj@bjut.edu.cn
Lin
Tai-feng
TF
Zhang
Shu-fen
SF
Liu
Rui
R
Zhong
Ru-gang
RG
D001564:Benzo(a)pyrene / Q000737:chemistry / Q000378:metabolism*; D004785:Environmental Pollutants / Q000737:chemistry / Q000378:metabolism; D009153:Mutagens / Q000737:chemistry / Q000378:metabolism; D016877:Oxidants / Q000737:chemistry / Q000378:metabolism*; D030421:Peroxynitrous Acid / Q000737:chemistry / Q000378:metabolism*; D011166:Porphyrins / Q000737:chemistry / Q000378:metabolism*
D004785:Environmental Pollutants; D009153:Mutagens; D016877:Oxidants; D011166:Porphyrins; D030421:Peroxynitrous Acid; D001564:Benzo(a)pyrene