Conjunctival melanoma 3 years after radiation and chemotherapy for retinoblastoma.
An 8-month-old infant with advanced bilateral retinoblastoma was managed with enucleation of the right eye and chemotherapy and radiotherapy of the left eye. Three years after treatment, an ill-defined, nonpigmented mass was noted in the anophthalmic right socket. Excisional biopsy revealed an amelanotic melanoma of the conjunctiva with superficial orbital invasion. There has been no tumor recurrence during 20 months of follow-up.
Mahajan
Amita
A
Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Shields
Carol L
CL
Eagle
Ralph C
RC
Mashayekhi
Arman
A
Freire
Jorge E
JE
Shields
Jerry A
JA
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003230:Conjunctival Neoplasms / Q000473:pathology*; D005047:Etoposide / Q000008:administration & dosage; D015353:Eye Enucleation; D006801:Humans; D007223:Infant; D008297:Male; D018328:Melanoma, Amelanotic / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D011882:Radiotherapy, High-Energy; D019572:Retinal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D012175:Retinoblastoma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D005047:Etoposide; D016190:Carboplatin