Evaluation of two antimicrobial therapies in the treatment of Leptospira borgpetersenii serovar hardjo infection in experimentally infected cattle.
This study demonstrated the ability of the antimicrobials tulathromycin (Draxxin) and ceftiofur crystalline free acid sterile suspension (Excede) to clear the spirochete Leptospira borgpetersenii serovar hardjo type hardjo-bovis (L. hardjo-bovis) from experimentally infected cattle. Treatment with tulathromycin resulted in clearance of L. hardjo-bovis organisms from the urine and kidney tissue of all animals (9 of 9), and treatment with ceftiofur crystalline free acid resulted in clearance of the organisms from the urine of 8 of 10 heifers and the kidney tissue of all 10 animals. In contrast, 10 of 10 placebo-treated cattle had L. hardjo-bovis organisms in their urine and 8 of 10 had the organisms in kidney tissue.
Cortese
Victor S
VS
Pfizer Animal Health, Veterinary Specialty Operations Cattle Immunology, Simpsonville, KY 40067, USA.
Behan
Stephen
S
Galvin
Jeff E
JE
Penka
Dan R
DR
Ramsey
Deborah
D
Bryson
W Lawrence
WL
Lucas
Merlyn J
MJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D002511:Cephalosporins / Q000627:therapeutic use; D004187:Disaccharides / Q000627:therapeutic use*; D005260:Female; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D007919:Leptospira / Q000187:drug effects; D007922:Leptospirosis / Q000188:drug therapy / Q000662:veterinary*; D011897:Random Allocation; D016896:Treatment Outcome; D018942:Macrolides
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004187:Disaccharides; D006571:Heterocyclic Compounds; C053503:ceftiofur; C485204:tulathromycin; D018942:Macrolides