Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma.
Mantle cell lymphoma (MCL) is defined pathologically by the detection of CD20, CD5, and most importantly cyclin D1 (CCND1). Its distinction from other lymphomas is important for prognosis and appropriate therapy, but occasional cases may fail to express CCND1 and morphologic simulators may express CD20 and CD5 but not CD23. In this study, we show that the transcription factor Sox11 is specifically expressed in the nucleus of MCL compared with other lymphomas and benign lymphoid tissue. Although the role of Sox11 presently is not known in lymphocyte ontogeny, it is normally expressed in the developing central nervous system in the embryo and shows sequence homology with Sox4, a transcription factor crucial for B lymphopoiesis. Sox11 mRNA is increased in gliomas compared with healthy brain tissue, suggesting a role in malignant transformation and/or cell survival. Our novel finding of specific overexpression of Sox11 mRNA and nuclear protein in both cyclin D1-positive and - negative MCL may be useful for the diagnosis of MCL as a complement to cyclin D1 and also suggests a functional role for Sox11 in MCL.
Ek
Sara
S
Department of Immunotechnology, CREATE Health, BioMedical Center, Lund University, and Department of Pathology, Lund University Hospital, Sweden. sara.ek@immun.lth.se
Dictor
Michael
M
Jerkeman
Mats
M
Jirström
Karin
K
Borrebaeck
Carl A K
CA
D018951:Antigens, CD20 / Q000235:genetics / Q000378:metabolism; D001402:B-Lymphocytes / Q000473:pathology; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D018956:CD5 Antigens / Q000235:genetics / Q000378:metabolism; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002490:Central Nervous System / Q000196:embryology / Q000378:metabolism / Q000473:pathology; D056741:Cyclin D; D016213:Cyclins / Q000235:genetics / Q000378:metabolism; D004622:Embryo, Mammalian / Q000378:metabolism / Q000473:pathology; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D015973:Gene Expression Regulation, Leukemic; D005910:Glioma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006609:High Mobility Group Proteins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D038041:Lymphopoiesis / Q000235:genetics; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D009928:Organ Specificity; D055751:SOXC Transcription Factors; D017386:Sequence Homology, Amino Acid; D015534:Trans-Activators / Q000096:biosynthesis / Q000235:genetics
D018951:Antigens, CD20; D014408:Biomarkers, Tumor; D018956:CD5 Antigens; D056741:Cyclin D; D016213:Cyclins; D006609:High Mobility Group Proteins; D009363:Neoplasm Proteins; C097473:SOX11 protein, human; C083431:SOX4 protein, human; D055751:SOXC Transcription Factors; D015534:Trans-Activators