title: Human herpesvirus 6 (HHV-6)-associated pleurisy after unrelated cord blood transplantation in children with chemotherapy-resistant malignant Lymphoma.
abstract: Two children, 5 and 10 years of age, received unrelated cord blood transplantation (CBT) for malignant lymphoma. Both of them suffered from pleurisy with and without interstitial pneumonitis after transplantation. By the quantitative real-time polymerase chain reaction, human herpesvirus 6 (HHV-6) variant B DNA was detected in pleural effusion. This is the first report of HHV-6-associated pleurisy after hematopoietic stem cell transplantation. HHV-6-associated pleurisy should be considered as a complication after hematopoietic stem cell transplantation even in the absence of pneumonitis. Quantitative polymerase chain reaction is a useful tool for rapid detection of viral DNA, which may facilitate precise diagnosis and appropriate treatment.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan. aikosu@mailserver.med.kyushu-u.ac.jp
authors.forename: Aiko
authors.initials: A
authors.lastname: Suminoe
authors.forename: Akinobu
authors.initials: A
authors.lastname: Matsuzaki
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Koga
authors.forename: Koichi
authors.initials: K
authors.lastname: Kusuhara
authors.forename: Toshiro
authors.initials: T
authors.lastname: Hara
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D004279:DNA, Viral / Q000235:genetics; D019008:Drug Resistance, Neoplasm; D005260:Female; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D008223:Lymphoma / Q000150:complications / Q000188:drug therapy*; D008297:Male; D010998:Pleurisy / Q000628:therapy / Q000821:virology*; D016133:Polymerase Chain Reaction; D019349:Roseolovirus Infections / Q000628:therapy / Q000821:virology*
chemical_list: D004279:DNA, Viral