title: Clinical features of early and late stage polypoidal choroidal vasculopathy characterized by lesion size and disease duration.
abstract: BACKGROUND
  The pathogenesis of polypoidal choroidal vasculopathy (PCV), and even its clinical features, are controversial. Previous histopathological studies have identified different features; either dilated choroidal vessels or intra-Bruch's neovascularization. These differences might be partly attributable to the influence of the disease stage. We therefore evaluated the clinical features of early and late stage PCV.
  
  
  METHODS
  The medical records of 110 eyes of 97 PCV patients were retrospectively reviewed. The time between the subjective onset of visual abnormality and examination at our clinic and the greatest linear dimension of the total lesion at the first examination were investigated. The period of disturbed vision and lesion size data were placed in ascending order to determine the first quartile point. Eyes with both values at or below the first quartile point were classified as 'small-short' (early stage). Eyes with both values equal to at least the third quartile point were classified as 'large-long' (late stage). Fundus photography, indocyanine green and fluorescein angiography, visual acuity, and clinical course were compared.
  
  
  RESULTS
  Twelve eyes from 12 patients were small-short cases (period of disturbed vision of 1 month or less, lesion size 2.0 disc diameters or less). Eleven eyes from ten patients were large-long cases (period of disturbed vision 36 months or more, lesion size at least 5.0 disc diameters). The large-long eyes were characterized by occult choroidal neovascular membrane or scar tissue secondary to exudative age-related macular degeneration. Noticeable in the small-short eyes were atrophic changes in the retinal pigment epithelium, choroidal vessel hyperpermeability and pulsation. The visual prognosis and clinical course were different between the groups.
  
  
  CONCLUSIONS
  The difference of clinical features between the groups might reflect different disease stages, although not all of the features observed in the small-short group appeared to represent the early stages of those recorded in the large-long group. Thus, the variation in histopathologic features among previous reports might be partly attributable to differences in disease stage.
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. akiko@m2.kufm.kagoshima-u.ac.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Okubo
authors.forename: Mayumi
authors.initials: M
authors.lastname: Hirakawa
authors.forename: Motoko
authors.initials: M
authors.lastname: Ito
authors.forename: Munefumi
authors.initials: M
authors.lastname: Sameshima
authors.forename: Taiji
authors.initials: T
authors.lastname: Sakamoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000098:blood supply*; D015862:Choroid Diseases / Q000145:classification / Q000175:diagnosis* / Q000628:therapy; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007208:Indocyanine Green; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000145:classification / Q000175:diagnosis* / Q000628:therapy; D010778:Photochemotherapy; D012189:Retrospective Studies; D014792:Visual Acuity
chemical_list: D004396:Coloring Agents; D005938:Glucocorticoids; D007208:Indocyanine Green