Synthesis, characterization and cytotoxicity of diam(m)-ineplatinum(II) complexes containing beta-phenylisosuccinate ligand.
Four diam(m)ineplatinum(II) complexes containing beta-phenylisosuccinate as the leaving groups were prepared, characterized, and evaluated for their cytotoxicity against A549/ATCC human lung cancer cell line and SGC-7901 human gastric cancer cell line. One of the complexes, (trans-1R,2R-diaminocyclohexane)-beta-phenylisosuccinatoplatinum(II) 4, was much more active than cisplatin and carboplatin.
Ye
Qing-Song
QS
Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming, Yunnan, China.
Lou
Li-Guang
LG
Liu
Zuo-Yan
ZY
Liu
Wei-Ping
WP
Hou
Shu-Qian
SQ
Chen
Xi-Zhu
XZ
Yu
Yao
Y
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000031:analogs & derivatives*; D015195:Drug Design; D006801:Humans; D007536:Isomerism; D008024:Ligands; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D013386:Succinates / Q000737:chemistry*
D000970:Antineoplastic Agents; D008024:Ligands; D009944:Organoplatinum Compounds; D013386:Succinates; C017625:2-phenylsuccinate; D002945:Cisplatin