title: Evaluation of two antimicrobial therapies in the treatment of Leptospira borgpetersenii serovar hardjo infection in experimentally infected cattle.
abstract: This study demonstrated the ability of the antimicrobials tulathromycin (Draxxin) and ceftiofur crystalline free acid sterile suspension (Excede) to clear the spirochete Leptospira borgpetersenii serovar hardjo type hardjo-bovis (L. hardjo-bovis) from experimentally infected cattle. Treatment with tulathromycin resulted in clearance of L. hardjo-bovis organisms from the urine and kidney tissue of all animals (9 of 9), and treatment with ceftiofur crystalline free acid resulted in clearance of the organisms from the urine of 8 of 10 heifers and the kidney tissue of all 10 animals. In contrast, 10 of 10 placebo-treated cattle had L. hardjo-bovis organisms in their urine and 8 of 10 had the organisms in kidney tissue.
authors.affiliation: Pfizer Animal Health, Veterinary Specialty Operations Cattle Immunology, Simpsonville, KY 40067, USA.
authors.forename: Victor S
authors.initials: VS
authors.lastname: Cortese
authors.forename: Stephen
authors.initials: S
authors.lastname: Behan
authors.forename: Jeff E
authors.initials: JE
authors.lastname: Galvin
authors.forename: Dan R
authors.initials: DR
authors.lastname: Penka
authors.forename: Deborah
authors.initials: D
authors.lastname: Ramsey
authors.forename: W Lawrence
authors.initials: WL
authors.lastname: Bryson
authors.forename: Merlyn J
authors.initials: MJ
authors.lastname: Lucas
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D002511:Cephalosporins / Q000627:therapeutic use; D004187:Disaccharides / Q000627:therapeutic use*; D005260:Female; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D007919:Leptospira / Q000187:drug effects; D007922:Leptospirosis / Q000188:drug therapy / Q000662:veterinary*; D011897:Random Allocation; D016896:Treatment Outcome; D018942:Macrolides
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004187:Disaccharides; D006571:Heterocyclic Compounds; C053503:ceftiofur; C485204:tulathromycin; D018942:Macrolides