Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms.
MTHFR gene variants C677T and A1298C seem to be related to an increased risk of migraine. Folates' metabolism could play a role in the pathophysiology of migraine. We supplemented 16 children with migraine, hyperhomocysteinemia, and MTHFR polymorphisms with folic acid and obtained a resolution/reduction of migraine attacks. Although the mechanism leading to these effects has been not made clear, we believe that the use of folic acid needs further investigations in migraineurs with hyperhomocysteinemia and MTHFR variants. A randomized, double-blind, placebo controlled crossover trial is needed to support these findings.
Di Rosa
Gabriella
G
Department of Medical and Surgical Pediatrics, Unit of Infantile Neuropsychiatry, University Hospital of Messina, Messina, Italy.
Attinà
Sarina
S
Spanò
Maria
M
Ingegneri
Giulia
G
Sgrò
Domenica L
DL
Pustorino
Giuseppina
G
Bonsignore
Maria
M
Trapani-Lombardo
Vincenzo
V
Tortorella
Gaetano
G
D000293:Adolescent; D002648:Child; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008881:Migraine Disorders / Q000150:complications* / Q000188:drug therapy / Q000235:genetics*; D011110:Polymorphism, Genetic; D016896:Treatment Outcome
D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2)