New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation.
We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro.
Frohn
Mike
M
Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. mfrohn@amgen.com
Xu
Han
H
Zou
Xiaoming
X
Chang
Catherine
C
McElvaine
Michele
M
Plant
Matthew H
MH
Wong
Min
M
Tagari
Philip
P
Hungate
Randall
R
Bürli
Roland W
RW
D000818:Animals; D001562:Benzimidazoles / Q000819:agonists / Q000138:chemical synthesis / Q000494:pharmacology; D016466:CHO Cells; D002464:Cell Migration Inhibition; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D018836:Inflammation Mediators / Q000819:agonists / Q000502:physiology*; D015850:Interleukin-6 / Q000378:metabolism; D015335:Molecular Probes / Q000032:analysis* / Q000138:chemical synthesis*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D044042:Receptors, Formyl Peptide / Q000819:agonists / Q000097:blood / Q000502:physiology*; D044067:Receptors, Lipoxin / Q000819:agonists / Q000097:blood / Q000502:physiology*
D001562:Benzimidazoles; C105101:FPR2 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D015335:Molecular Probes; D044042:Receptors, Formyl Peptide; D044067:Receptors, Lipoxin; C014353:benzimidazolone