title: Apocrine adenoma of the breast coexistent with invasive carcinoma.
abstract: We describe a case of apocrine adenoma with simultaneous occurrence of invasive ductal carcinoma in the breast of a 53-year-old woman. Apocrine adenoma affecting the breast is very rare. The lesion is composed of back-to-back ducts and papillary fronds covered with apocrine cells, and it is sharply demarcated from the surrounding breast tissue. The patient presented with a palpable nodule with skin retraction in her right breast, where ultrasound examination identified a 5-mm hypoechogenic nodule. The ultrasound also revealed in the surrounding breast parenchyma an additional abnormal finding suggestive of carcinoma. Histologic examination of the excised specimen showed that the hypoechogenic nodule represented an apocrine adenoma in proximity to the invasive ductal breast carcinoma. This is the first report that describes the simultaneous occurrence of these two lesions in the same breast.
authors.affiliation: Institute of Pathology, Cytology and Forensic Medicine, Clinical Hospital Split, Spincićeva 1, 21000, Split, Croatia. jb@mefst.hr
authors.forename: Josko
authors.initials: J
authors.lastname: Bezić
authors.forename: Gea
authors.initials: G
authors.lastname: Forempoher
authors.forename: Ana
authors.initials: A
authors.lastname: Poljicanin
authors.forename: Grgo
authors.initials: G
authors.lastname: Gunjaca
mesh_terms: D006607:Adenoma, Sweat Gland / Q000378:metabolism / Q000473:pathology*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology*; D011960:Receptors, Estrogen / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis; D013544:Sweat Gland Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone