title: Outcome of Escherichia coli and/or Klebsiella bloodstream infection in children with central venous catheters.
abstract: We conducted a retrospective cohort study of children with catheter-associated bloodstream infections (BSIs) due to Escherichia coli and/or Klebsiella. Risk factors for poor outcome (ie, death or recurrence of infection) were receipt of mechanical ventilation (adjusted odds ratio [aOR], 4.6 [95% confidence interval {CI}, 1.39-16.30]) and receipt of total parenteral nutrition (aOR, 3.5 [95% CI, 1.1-10.8]). A significant proportion of children with catheter-associated BSI were treated successfully without catheter removal.
authors.affiliation: Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Buckley
authors.forename: Susan E
authors.initials: SE
authors.lastname: Coffin
authors.forename: Ebbing
authors.initials: E
authors.lastname: Lautenbach
authors.forename: Priya
authors.initials: P
authors.lastname: Prasad
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Chu
authors.forename: Monika
authors.initials: M
authors.lastname: Goyal
authors.forename: Theoklis E
authors.initials: TE
authors.lastname: Zaoutis
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000097:blood / Q000209:etiology* / Q000628:therapy; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007710:Klebsiella Infections / Q000097:blood / Q000209:etiology* / Q000628:therapy; D008297:Male; D010289:Parenteral Nutrition, Total; D012008:Recurrence; D012121:Respiration, Artificial; D018805:Sepsis / Q000209:etiology* / Q000382:microbiology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents