No potassium, no acid: K+ channels and gastric acid secretion.
The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.
Heitzmann
Dirk
D
Institute of Physiology, Regensburg, Germany.
Warth
Richard
R
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D006801:Humans; D051657:KCNQ1 Potassium Channel / Q000378:metabolism; D010295:Parietal Cells, Gastric / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D011188:Potassium / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying / Q000378:metabolism; D024642:Potassium Channels, Voltage-Gated / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D051657:KCNQ1 Potassium Channel; D024661:Potassium Channels, Inwardly Rectifying; D024642:Potassium Channels, Voltage-Gated; D017506:H(+)-K(+)-Exchanging ATPase; D011188:Potassium