Trifluoromethylation of salicyl aldimines.
A method for the nucleophilic trifluoromethylation of salicyl aldimines, which do not contain an activating group at the nitrogen atom, has been described. The reaction proceeds through the initial generation of intramolecular boron complex followed by interaction with Me3SiCF3 activated by sodium acetate.
Dilman
Alexander D
AD
N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation. adil25@mail.ru
Arkhipov
Dmitry E
DE
Levin
Vitalij V
VV
Belyakov
Pavel A
PA
Korlyukov
Alexander A
AA
Struchkova
Marina I
MI
Tartakovsky
Vladimir A
VA
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D054879:Halogenation; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008745:Methylation; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D000588:Amines; D006845:Hydrocarbons, Fluorinated; D007097:Imines