title: Radiation-induced antitumor properties of vitamin B5 (pantothenic acid) and its effect on mitomycin C activity: experiments in vitro.
abstract: Vitamin B5 (pantothenic acid) shows a strongly pronounced antitumor effect under the influence of ionizing radiation. In the frame of experiments in vitro (model: Escherichia coli bacteria, AB1157) performed under the exact knowledge of concentration and kind of the free radicals acting in the various aqueous media (pH 7.4) the following was established: (i) vitamin B5 possesses a very intense antitumor property, (ii) it exerts a strong synergistic effect on mitomycin C (MMC), (iii) the oxidizing species (OH*, O2*-) appears to be most important in the initiation of the observed effect. The generated radiolytic products from vitamin B5 very likely also play an important role in this respect.
authors.affiliation: Section Radiation Biology, Department of Nutrition Sciences, The University of Vienna, A-1090 Vienna, Austria.
authors.forename: Heike
authors.initials: H
authors.lastname: Schittl
authors.forename: Nikola
authors.initials: N
authors.lastname: Getoff
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D005720:Gamma Rays; D016685:Mitomycin / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism; D010205:Pantothenic Acid / Q000737:chemistry / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D005609:Free Radicals; D011838:Radiation-Sensitizing Agents; D017382:Reactive Oxygen Species; D010205:Pantothenic Acid; D016685:Mitomycin; D010100:Oxygen