title: Cytotoxic mycoepoxydiene derivatives from an endophytic fungus Phomopsis sp. isolated from Hydnocarpus anthelminthicus.
abstract: Mycoepoxydiene ( 1) and derivatives, deacetylmycoepoxydiene ( 2) and 2,3-dihydromycoepoxydiene ( 3), were isolated from a broth extract of the endophytic fungus, phomopsis sp., which was isolated from a Thai medicinal plant, Hydnocarpus anthelminthicus. Compounds 1 and 2 exhibited potent cytotoxic activity, while a dihydro derivative 3 was inactive. The present work suggests that the alpha,beta-unsaturated lactone moiety in mycoepoxydienes might be responsible for the cytotoxicity.
authors.affiliation: Chulabhorn Research Institute and Chulabhorn Graduate Institute, Vipavadee-Rangsit Highway, Bangkok, Thailand.
authors.forename: Surasak
authors.initials: S
authors.lastname: Prachya
authors.forename: Suthep
authors.initials: S
authors.lastname: Wiyakrutta
authors.forename: Nongluksna
authors.initials: N
authors.lastname: Sriubolmas
authors.forename: Nattaya
authors.initials: N
authors.lastname: Ngamrojanavanich
authors.forename: Chulabhorn
authors.initials: C
authors.lastname: Mahidol
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
authors.forename: Prasat
authors.initials: P
authors.lastname: Kittakoop
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D003904:Mitosporic Fungi; D008517:Phytotherapy; D011753:Pyrones / Q000737:chemistry*; D031308:Salicaceae / Q000382:microbiology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001952:Bridged-Ring Compounds; D011753:Pyrones; C476085:mycoepoxydiene