title: Decrease in myocardial 123I-MIBG radioactivity in REM sleep behavior disorder: two patients with different clinical progression.
abstract: Although decrease in myocardial iodine-123 metaiodobenzylguanidine ((123)I-MIBG) radioactivity has been reported in patients with rapid eye movement (REM) sleep behavior disorder (RBD), its pathophysiology has not been thoroughly disclosed. We report two RBD patients with differing clinical progression, in whom myocardial (123)I-MIBG scintigraphy was performed. One 69-year-old patient had more than a 20-year history of idiopathic RBD and showed a decrease in myocardial (123)I-MIBG radioactivity. The other 69-year-old patient started to manifest nocturnal behaviors at age 62, then mild parkinsonism at age 68, and showed a similar decrease in myocardial (123)I-MIBG radioactivity both before and after the onset of parkinsonism. These cases suggest that RBD could develop in diverse patterns of clinical progression even if signs of underlying Lewy body pathology are uniformly indicated.
authors.affiliation: Human Brain Research Center, Kyoto University Graduate School of Medicine, Shogoin, Sakyo, Kyoto 606-8507, Japan. toguri@kuhp.kyoto-u.ac.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Oguri
authors.forename: Naoko
authors.initials: N
authors.lastname: Tachibana
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Mitake
authors.forename: Taketo
authors.initials: T
authors.lastname: Kawanishi
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
mesh_terms: D019797:3-Iodobenzylguanidine; D017668:Age of Onset; D000368:Aged; D018450:Disease Progression; D004562:Electrocardiography; D005500:Follow-Up Studies; D006321:Heart / Q000294:innervation; D006801:Humans; D020961:Lewy Body Disease / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010300:Parkinson Disease / Q000000981:diagnostic imaging; D017286:Polysomnography; D020187:REM Sleep Behavior Disorder / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D017779:Sympathetic Fibers, Postganglionic / Q000503:physiopathology
chemical_list: D019797:3-Iodobenzylguanidine