Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats.
Microbial breakdown of carbohydrates in the large intestine mainly produces short-chain fatty acids (SCFA). SCFA stimulate epithelial cell proliferation of the digestive tract in vivo. Succinic acid sometimes accumulates in the colonic lumen. However, the effect of succinic acid on colonic epithelial cell proliferation is unknown. Thus, we planned to clarify the influence of succinic acid on colonic epithelial cell proliferation in vivo. We continuously administered infusate with or without succinic acid (100 mM) into the distal colon of rats for 6 d and measured accumulated mitosis per crypt of distal colon of these rats. Succinic acid infused into rat colons significantly inhibited colonic cell proliferation and reduced crypt size. These results clearly indicated the inhibitory effects of succinic acid on colonic epithelial cell proliferation in vivo.
Inagaki
Akiko
A
School of Science and Engineering, Ishinomaki Senshu University, Ishinomaki, Japan.
Ichikawa
Hirofumi
H
Sakata
Takashi
T
D000818:Animals; D002452:Cell Count; D048708:Cell Growth Processes / Q000187:drug effects; D003106:Colon / Q000166:cytology / Q000187:drug effects*; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D006651:Histocytochemistry; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D019802:Succinic Acid / Q000494:pharmacology*
D019802:Succinic Acid