Current concepts in antibiotic-resistant gram-negative bacteria.
Gram-negative bacteria are the dominant killers among bacterial pathogens in the intensive care unit. Antibiotic resistance has become a threat in hospital settings and efforts are being made to understand the underlying mechanisms. This review describes current data on the most important mechanisms of resistance in prevalent gram-negative pathogens as well as newer therapeutic options.
Torres
Julián Andrés
JA
CIDEIM (International Center for Medical Research and Training), Avenida 1N # 3-03, Cali, Colombia. jtorres@cideim.org.co
Villegas
Maria Virginia
MV
Quinn
John P
JP
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000502:physiology; D001692:Biological Transport; D015780:Carbapenems / Q000494:pharmacology / Q000627:therapeutic use; D002463:Cell Membrane Permeability; D003428:Cross Infection / Q000188:drug therapy; D024901:Drug Resistance, Multiple, Bacterial / Q000502:physiology*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007362:Intensive Care Units; D009154:Mutation; D018272:Porins / Q000235:genetics / Q000502:physiology; D018571:Sentinel Surveillance
D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D015780:Carbapenems; D018272:Porins