Citalopram induced torsade de pointes, a rare life threatening side effect.
Acquired Long QT syndrome is a disorder caused by medications, electrolyte imbalances, and drug interactions. This syndrome is associated with an increased risk of a characteristic life-threatening cardiac arrhythmia, known as torsade de pointes (TdP). In the setting of Long QT syndrome (LQTS), selective serotonin reuptake inhibitors (SSRIs) can precipitate TdP. We report the first case of LQTS and TdP induced by citalopram in the United States. After discontinuation of citalopram, the QT/QTc interval normalized after 3 days and resolved further episodes of TdP. Patients on citalopram should be monitored closely for QT/QTc interval to prevent torsade de pointes.
Kanjanauthai
Somsupha
S
Kanluen
Tony
T
Chareonthaitawee
Panithaya
P
D000369:Aged, 80 and over; D015283:Citalopram / Q000009:adverse effects*; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology
D015283:Citalopram