Violacein: properties and biological activities.
The violet pigment violacein is an indole derivative, isolated mainly from bacteria of the genus Chromobacterium, which exhibits important antitumoral, antimicrobial and antiparasitary properties. Furthermore, the formulation of violacein in different polymeric carriers developed so far offers alternative approaches to overcoming physiological barriers and undesirable physicochemical properties in vivo, thus improving its efficacy.
Durán
Nelson
N
Laboratório de Quimica Biológica, Instituto de Química, Universidade Estadual de Campinas (UNICAMP), C.P. 6154, CEP 13083-970, Campinas, SP, Brazil. duran@iqm.unicamp.br
Justo
Giselle Z
GZ
Ferreira
Carmen V
CV
Melo
Patrícia S
PS
Cordi
Livia
L
Martins
Dorival
D
D000890:Anti-Infective Agents / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D002861:Chromobacterium / Q000737:chemistry; D006801:Humans; D007211:Indoles / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D007211:Indoles; C063155:violacein