title: Effects of talc dust on respiratory health: results of a longitudinal survey of 378 French and Austrian talc workers.
abstract: OBJECTIVE
  The aim of this longitudinal study was to investigate the effects on respiratory health of talc dust, free of asbestiform fibres, at or below airborne concentrations of 2 mg/m(3).
  
  
  METHODS
  The respiratory health and dust exposure of all workers with at least 5 years of employment at two talc producing facilities in France and Austria were surveyed between 1988 and 2003. Standard forced expiratory volumes and standard chest x rays were obtained on repeated occasions and recorded using strict quality control procedures. Of a target population of 430 subjects, 378 (88%) were examined at least twice. A quantitative exposure matrix was set up based on 4602 personal exposure measurements of respirable dust and qualitative descriptions of the industrial processes and individual protection devices.
  
  
  RESULTS
  The mean duration of follow-up was 14.5 years with a mean estimated talc dust concentration during follow-up of 1.46 mg/m(3). The prevalence of small radiological opacities and lung function parameters were significantly related to cumulative exposure at inclusion but not to exposure during the study period. Overall, the forced expiratory volume in 1 s decreased by 66 ml per 100 years.mg/m(3), which is less than that reported for other types of mineral dusts.
  
  
  CONCLUSIONS
  Although early exposure levels to talc as assessed at inclusion were associated with decreased lung function and an increased prevalence of small radiological opacities, there was no evidence of detrimental effects of talc exposure, as assessed within the study period, on lung function and small radiological opacities.
authors.affiliation: INRS, Département Epidemiologie en Entreprise, BP 27, 54501 Vandoeuvre cedex, France. pascal.wild@inrs.fr
authors.forename: P
authors.initials: P
authors.lastname: Wild
authors.forename: K
authors.initials: K
authors.lastname: Leodolter
authors.forename: M
authors.initials: M
authors.lastname: Réfrégier
authors.forename: H
authors.initials: H
authors.lastname: Schmidt
authors.forename: E
authors.initials: E
authors.lastname: Bourgkard
mesh_terms: D000293:Adolescent; D000328:Adult; D004391:Dust; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis; D012120:Respiration Disorders / Q000209:etiology; D003074:Solitary Pulmonary Nodule / Q000209:etiology*; D013627:Talc / Q000009:adverse effects* / Q000032:analysis; D014797:Vital Capacity
chemical_list: D004391:Dust; D013627:Talc