title: In vitro study of Candida tropicalis isolates exhibiting paradoxical growth in the presence of high concentrations of caspofungin.
abstract: Paradoxical growth was noted in RPMI 1640 and antibiotic medium 3 in the case of 14 and 1 of 15 Candida tropicalis strains, respectively, at a caspofungin concentration of 12.5 microg/ml using minimum fungicidal concentration tests. Time-kill assays showed that against isolates killed at lower concentrations, caspofungin at a concentration of 12.5 microg/ml was only fungistatic.
authors.affiliation: Department of Medical Microbiology, Medical and Science Center, University of Debrecen, 4032 Debrecen, Nagyerdei, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Sóczó
authors.forename: G
authors.initials: G
authors.lastname: Kardos
authors.forename: I
authors.initials: I
authors.lastname: Varga
authors.forename: B
authors.initials: B
authors.lastname: Kelentey
authors.forename: R
authors.initials: R
authors.lastname: Gesztelyi
authors.forename: L
authors.initials: L
authors.lastname: Majoros
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D041022:Candida tropicalis / Q000187:drug effects* / Q000254:growth & development; D000077336:Caspofungin; D054714:Echinocandins / Q000494:pharmacology*; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin