title: Correlation between cystatin C- and renal scan-determined glomerular filtration rate in children with spina bifida.
abstract: We report on the relationships between serum cystatin C level, glomerular filtration rate (GFR) estimated from a cystatin C-based prediction equation (that of Filler and Lepage), GFR calculated by the Schwartz formula and technetium 99m-diethylene triamine penta-acetic acid ((99)Tc-DTPA)-determined GFR in 28 children with spina bifida. All children underwent measurement of height, weight, serum cystatin C level, and serum creatinine level at the time of their renal scan. The relationship between variables was assessed by Pearson correlation. Pearson correlation for the relationship between (99)Tc-DTPA GFR and GFR calculated by the cystatin C-based equation was significant and higher than that of the relationship between (99)Tc-DTPA GFR and GFR calculated by the Schwartz equation, which was not statistically significant. The correlation for Filler GFR was 0.42 (P = 0.03) and for Schwartz GFR was 0.21 (P = 0.28). Although we use renal scan determination of GFR as the best measure, and a creatinine-based formula as the most practical measure, perhaps a formula such as that published by Filler and Lepage, which is not dependent on anthropometric data, might be a more useful (and accurate) tool for establishing GFR in children with spina bifida.
authors.affiliation: Pediatric Nephrology, Department of Pediatrics, University of Alberta, 2B2-42 Walter Mac Kenzie Health Science Centre, Edmonton, T6G 2R7, AB, Canada.
authors.forename: Catherine
authors.initials: C
authors.lastname: Morgan
authors.forename: Ambikaipakan
authors.initials: A
authors.lastname: Senthilselvan
authors.forename: Fiona
authors.initials: F
authors.lastname: Bamforth
authors.forename: Michael
authors.initials: M
authors.lastname: Hoskinson
authors.forename: Manjula
authors.initials: M
authors.lastname: Gowrishankar
mesh_terms: D000293:Adolescent; D002556:Cerebrospinal Fluid Proteins / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D011866:Radioisotope Renography; D019275:Radiopharmaceuticals; D012044:Regression Analysis; D016135:Spinal Dysraphism / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D016284:Technetium Tc 99m Pentetate
chemical_list: C525030:CST3 protein, human; D002556:Cerebrospinal Fluid Proteins; D055316:Cystatin C; D015891:Cystatins; D019275:Radiopharmaceuticals; D003404:Creatinine; D016284:Technetium Tc 99m Pentetate