Bidirectional genetic and environmental influences on mother and child behavior: the family system as the unit of analyses.
Family systems theory proposes that an individual's functioning depends on interactive processes within the self and within the context of dyadic family subsystems. Previous research on these processes has focused largely on behavioral, cognitive, and psychophysiological properties of the individual and the dyad. The goals of this study were to explore genetic and environmental interactions within the family system by examining how the dopamine receptor D2 gene (DRD2) A1+ polymorphism in mothers and children relates to maternal sensitivity, how maternal and child characteristics might mediate those effects, and whether maternal sensitivity moderates the association between DRD2 A1+ and child affective problems. Evidence is found for an evocative effect of child polymorphism on parenting behavior, and for a moderating effect of child polymorphism on the association between maternal sensitivity and later child affective problems. Findings are discussed from a family systems perspective, highlighting the role of the family as a context for gene expression in both mothers and children.
Mills-Koonce
W Roger
WR
Center for Developmental Science, University of North Carolina at Chapel Hill, 100 East Franklin Street, CB 8115, Chapel Hill, NC 27599-8115, USA. rmk@e-mail.unc.edu
Propper
Cathi B
CB
Gariepy
Jean-Louis
JL
Blair
Clancy
C
Garrett-Peters
Patricia
P
Cox
Martha J
MJ
D000328:Adult; D000342:Affective Symptoms / Q000235:genetics* / Q000523:psychology; D000704:Analysis of Variance; D002653:Child Behavior Disorders / Q000235:genetics* / Q000523:psychology; D002675:Child, Preschool; D005190:Family / Q000523:psychology*; D005260:Female; D015870:Gene Expression / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D008425:Maternal Behavior / Q000523:psychology*; D019964:Mood Disorders / Q000235:genetics / Q000523:psychology; D009034:Mother-Child Relations; D016487:Parenting / Q000523:psychology; D010552:Personality Assessment; D011110:Polymorphism, Genetic / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012931:Social Environment; D013223:Statistics as Topic; D013598:Systems Theory; D013694:Temperament
D017448:Receptors, Dopamine D2