Folding of a universal ribozyme: the ribonuclease P RNA.
Ribonuclease P is among the first ribozymes discovered, and is the only ubiquitously occurring ribozyme besides the ribosome. The bacterial RNase P RNA is catalytically active without its protein subunit and has been studied for over two decades as a model system for RNA catalysis, structure and folding. This review focuses on the thermodynamic, kinetic and structural frameworks derived from the folding studies of bacterial RNase P RNA.
Baird
Nathan J
NJ
Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA.
Fang
Xing-Wang
XW
Srividya
Narayanan
N
Pan
Tao
T
Sosnick
Tobin R
TR
D003198:Computer Simulation; D004789:Enzyme Activation; D008956:Models, Chemical; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D043262:Ribonuclease P / Q000737:chemistry* / Q000648:ultrastructure*
D043262:Ribonuclease P