Convenient access to 1,3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation.
Novel 1-aryl-3-(5-nitro-2-thienyl)-4-aroyl-pyrazoles 7 have been synthesized by the 1,3-dipolar cycloaddition of 3-arylsydnones 3 with 1-aryl-3-(5-nitro-2-thienyl)-2-propyn-1-ones 6. The newly synthesized compounds were well characterized by elemental analysis, IR, (1)H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies have been discussed in this article.
Rai
N Satheesha
NS
Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri-574 199, Karnataka, India.
Kalluraya
Balakrishna
B
Lingappa
B
B
Shenoy
Shaliny
S
Puranic
Vedavati G
VG
D000114:Acetylene / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D017672:Nitrogen Compounds / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013558:Sydnones / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D007659:Ketones; D017672:Nitrogen Compounds; D011720:Pyrazoles; D013558:Sydnones; D013876:Thiophenes; D000114:Acetylene