title: [Endovascular treatment of vasospasm following subarachnoid aneurysmal haemorrhage].
abstract: An endovascular treatment of vasospasm following a subarachnoid aneurysmal haemorrhage is to be implemented if the patient presents clinical or biological symptoms arguing for brain ischemia in conjunction with increased Doppler velocities despite well controlled systemic haemodynamic. Treatment might be either pharmacological or haemodynamic. Calcium and phosphodiesterase inhibitors can be administered. The former could also provide a neuroprotective effect as compared to the latter. In Europe, nimodipine is widely used whereas nicardipine and verapamil are the major molecules administered in North America where iv nimodipine is not FDA approved. Papaverine is less used nowadays because of its short duration of action and of the risk of aggravation of raised intracranial pressure. Balloon angioplasty has a long lasting effect but can be applied only to proximal spasm. Complications of its use are rare but life threatening. In some cases, both the pharmacological approach and the mechanical approach are used in combination.
authors.affiliation: Département d'anesthésie-réanimation, université Pierre-et-Marie-Curie-Paris-VI, 75651 Paris cedex 13, France.
authors.forename: L
authors.initials: L
authors.lastname: Abdennour
authors.forename: L
authors.initials: L
authors.lastname: Lejean
authors.forename: F
authors.initials: F
authors.lastname: Bonneville
authors.forename: A-L
authors.initials: AL
authors.lastname: Boch
authors.forename: L
authors.initials: L
authors.lastname: Puybasset
mesh_terms: D002121:Calcium Channel Blockers / Q000627:therapeutic use; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications*; D009529:Nicardipine / Q000627:therapeutic use; D009553:Nimodipine / Q000627:therapeutic use; D009599:Nitroprusside / Q000627:therapeutic use; D010208:Papaverine / Q000627:therapeutic use; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D020301:Vasospasm, Intracranial / Q000188:drug therapy* / Q000209:etiology
chemical_list: D002121:Calcium Channel Blockers; D010726:Phosphodiesterase Inhibitors; D009599:Nitroprusside; D009553:Nimodipine; D009529:Nicardipine; D010208:Papaverine