Early preweaning methamphetamine and postweaning rearing conditions interfere with the development of peripheral stress parameters and neural growth factors in gerbils.
Adrenal steroid hormones and neuronal growth factors are two interacting systemic factors that mediate the environment's influence on the brain's structure and function. In order to further elucidate their role and relationship in the effects of early stressful experience and isolated rearing (IR), this study measured blood corticosterone titres and relative adrenal weights and assessed nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) concentrations in brain regions of both hemispheres of young adult Mongolian gerbils injected on postnatal day 14 with a single high dose of methamphetamine (MA) or saline and raised after weaning either in an enriched or an impoverished environment. Irrespective of MA challenge, IR decreased corticosterone titres to about half, but increased relative adrenal weights. BDNF concentrations were decreased by IR in saline-injected animals in the left prefrontal and parietal cortices and right entorhinal and hippocampal cortices, and in the subcortical regions of both hemispheres. NGF concentrations were unaltered by IR in saline-injected animals, but increased in MA challenged animals in the entorhinal/hippocampal cortices and subcortical areas of both hemispheres. MA application induced shifts of the lateral asymmetry in NGF contents in prefrontal and entorhinal cortices. The results suggest that an early pharmacological traumatization can set a switch for further brain development, and that growth factor concentrations might possibly be influenced by peripheral stress hormones.
Lehmann
Konrad
K
Department of Neuroanatomy, Faculty of Biology, Bielefeld, Germany. Konrad.Lehmann@uni-jena.de
Rodriguez
Enrique Garea
EG
Kratz
Oliver
O
Moll
Gunther H
GH
Dawirs
Ralph R
RR
Teuchert-Noodt
Gertraud
G
D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D001921:Brain / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood; D004292:Dominance, Cerebral; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004777:Environment; D005849:Gerbillinae; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage* / Q000494:pharmacology; D009414:Nerve Growth Factors / Q000378:metabolism*; D009929:Organ Size; D012934:Social Isolation; D013312:Stress, Physiological / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D014886:Weaning
D019208:Brain-Derived Neurotrophic Factor; D000697:Central Nervous System Stimulants; D009414:Nerve Growth Factors; D008694:Methamphetamine; D003345:Corticosterone