[Definition of parameters of the condition of oxidizing stress in smooth muscle cells under influence of exogenous nitroso-glutatyon in vitro].
Influence of exogenous nitroso-glutatyon on intensity of oxidizing processes in smooth muscles of colon and bronchial tubes in intact and atopic sensitised porpoises (guinea pigs) was studied. In sensitised porpoises, antioxidant protection has been initially reduced against the background of increased maintenance of products of oxidizing that reflects a picture of oxidizing damage and can be associated with an inflammatory process. In incubation with nitroso-glutatyon, a decrease in activities of syperoxiddismutase and catalase is marked and, in sensitised animals, this effect has been expressed to a lesser degree. Syperoxiddismutase and catalase are antioxidant for the enzymes participating in protection of cells from free-radical damage. A dose-dependence decrease in activity catalase and syperoxiddismutase is defined by a parity of the enzymes participating in disintegration of nitrosoglutatyon and the enzymes which have kept antioxidant activity.
Kapilevich
L V
LV
Nosarev
A V
AV
D'iakova
E Iu
EIu
Andrushkevich
V V
VV
Nasedkina
A K
AK
Nosareva
O L
OL
Davlet'iarova
K V
KV
Ogorodova
L M
LM
Kovalev
I V
IV
Baskakov
M B
MB
Medvedev
M A
MA
D000818:Animals; D002374:Catalase / Q000032:analysis / Q000378:metabolism*; D006168:Guinea Pigs; D032389:Myocytes, Smooth Muscle / Q000187:drug effects* / Q000201:enzymology; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D018384:Oxidative Stress; D026422:S-Nitrosoglutathione / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism*
D020030:Nitric Oxide Donors; D026422:S-Nitrosoglutathione; D002374:Catalase; D013482:Superoxide Dismutase