title: Fluorescent probe ABM for screening gastrointestinal patient's immune state.
abstract: The fluorescent probe-aminoderivative of benzanthrone, ABM (developed at Riga Technical University, Riga, Latvia) was used to characterize the membranes of lymphocytes of cancer patients: 46 patients with gastrointestinal diseases, 13 patients having different primary localizations with massive metastases and intoxication. Patients were divided into three groups: (1) with decreased fluorescence intensity, (2) normal fluorescence intensity, (3) increased fluorescence intensity. The lymphocytes distribution among subsets differed between groups, in correspondence to the level of fluorescence intensity. Surgical treatment affected the main immunological parameters and elevated the functional activity of lymphocytes. In the advanced tumors group, fluorescence intensity correlates with the survival rate. Results suggest that determination of lymphocytes functional activity by ABM can aid evaluation of the immune status in cancer patients.
authors.affiliation: Department of Chemistry, Daugavpils University, Daugavpils, Latvia.
authors.forename: Inta
authors.initials: I
authors.lastname: Kalnina
authors.forename: Laura
authors.initials: L
authors.lastname: Klimkane
authors.forename: Elena
authors.initials: E
authors.lastname: Kirilova
authors.forename: Maija Malda
authors.initials: MM
authors.lastname: Toma
authors.forename: Gunta
authors.initials: G
authors.lastname: Kizane
authors.forename: Imants
authors.initials: I
authors.lastname: Meirovics
mesh_terms: D001551:Benz(a)Anthracenes / Q000737:chemistry; D002462:Cell Membrane / Q000276:immunology; D005456:Fluorescent Dyes / Q000737:chemistry; D005770:Gastrointestinal Neoplasms / Q000276:immunology* / Q000628:therapy; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D013050:Spectrometry, Fluorescence
chemical_list: D001551:Benz(a)Anthracenes; D005456:Fluorescent Dyes