Human psychoneuroimmunology: 20 years of discovery.
An important component of psychoneuroimmunology research is to reveal the myriad ways that behaviors and health are inter-related, with a focus on the immunological mechanisms that underlie these interactions. Research in human psychoneuroimmunology has shown that immunoregulatory processes are an integral part of a complex network of adaptive responses. As such, this review provides a perspective from our laboratory over the last 20 years to define the inter-relationships between behavior and immunity; to identify the hypothalamic pituitary adrenal (HPA) and autonomic mechanisms that link the central nervous system and immune responses; to examine the clinical implications of immune alterations during depression or life stress on inflammatory and infectious disease risk; and to explore the reciprocal role of immune mediators on behavior in humans.
Irwin
Michael R
MR
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, 300 Medical Plaza, Suite 3-109, Los Angeles, CA 90095-7057, USA. mirwin1@ucla.edu
D002318:Cardiovascular Diseases / Q000276:immunology; D002908:Chronic Disease; D003141:Communicable Diseases / Q000276:immunology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D011598:Psychoneuroimmunology / Q000266:history / Q000379:methods* / Q000639:trends*; D012890:Sleep / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology* / Q000503:physiopathology*