[Sonic hedgehog and prostate growth regulation].
Sonic hedgehog (Shh) is a key signal regulatory factor in embryonic development. It is reported that Shh signaling plays important roles in prostatic duct differentiation and matrix-epithelium interaction, and thus regulates the development, growth and cell proliferation of the prostate. A disorder in Shh signaling will lead to the production and proliferation of tumor cells. An exploration into the mechanism of Shh signaling in the normal growth and diseased condition of the prostate will offer some significant ideas for the studies on the pathogenesy of prostate diseases.
Yang
Li
L
Department of Urology, First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan 650032, China. yangynkm@126.com
Shen
Ji-hong
JH
Liu
Xiao-dong
XD
D000818:Animals; D053823:Hedgehog Proteins / Q000502:physiology*; D006801:Humans; D008297:Male; D011467:Prostate / Q000254:growth & development*; D015398:Signal Transduction / Q000502:physiology*
D053823:Hedgehog Proteins