High-speed complex conjugate resolved retinal spectral domain optical coherence tomography using sinusoidal phase modulation.
We demonstrate high-speed complex conjugate artifact (CCA) resolved imaging of human retina in vivo using spectral domain optical coherence tomography. This technique utilizes sinusoidal reference mirror modulation to implement high-speed integrating buckets acquisition and a quadrature projection reconstruction algorithm in postprocessing. This method is illustrated experimentally using sets of four integrating bucket phase scans, acquired at 52 kHz, for DC suppression of 73 dB and complex conjugate suppression of 35 dB. Densely sampled (3000 A-scans/image, acquired at 4.3 images/s) full-depth in vivo images of optic nerve head show CCA suppression for most image reflections to the noise floor.
Tao
Yuankai K
YK
Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Durham, North Carolina 27708, USA. yt13@duke.edu
Zhao
Mingtao
M
Izatt
Joseph A
JA
D000465:Algorithms; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012160:Retina / Q000166:cytology*; D042262:Retinoscopy / Q000379:methods*; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000379:methods; D041623:Tomography, Optical Coherence / Q000379:methods*