title: Phenolic compounds from sugarcane molasses possessing antibacterial activity against cariogenic bacteria.
abstract: During the course of our research into the use of cane by-products from sugar manufacturing, we have studied the isolation and structural determination of bioactive compounds present in sugarcane molasses. In this study, dehydrodiconiferylalcohol-9'-O-beta-D-glucopyranoside (1) and isoorientin-7, 3'-O-dimethyl ether (2) were isolated as antibacterial active compounds against cariogenic bacteria. Their structures were elucidated by (1)H-NMR, (13)C-NMR and ESI-MS. The activities of these isolated compounds against Streptococcus mutans and Streptococcus sobrinus were assessed by a minimum inhibitory concentration (MIC) test. The MICs of compounds 1 and 2 against both S. mutans and S. sobrinus were >4 mg/mL and 4 mg/mL, respectively.
authors.affiliation: Faculty of Agriculture, University of the Ryukyus, Nishihara-cho, Okinawa, Japan.
authors.forename: Kensaku
authors.initials: K
authors.lastname: Takara
authors.forename: Kenji
authors.initials: K
authors.lastname: Ushijima
authors.forename: Koji
authors.initials: K
authors.lastname: Wada
authors.forename: Hironori
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Yamashita
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003731:Dental Caries / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D008965:Molasses / Q000032:analysis*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031786:Saccharum / Q000737:chemistry*; D013295:Streptococcus mutans / Q000187:drug effects*; D016986:Streptococcus sobrinus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D010636:Phenols