The effects of sericin cream on wound healing in rats.
Sericin has good hydrophilic properties, compatibility, and biodegradation, it can be used as a wound-healing agent. We evaluated the effects of sericin on wound healing and wound size reduction using rats by generating two full-thickness skin wounds on the dorsum. Group 1 animals were treated with Betadine on left-side (control) wounds and, with 8% sericin cream on right-side (treated) wounds. Group 2, cream base (formula control) and 8% sericin cream (treated) were topically applied to left-, and right-side wounds respectively. Sericin-treated wounds had much smaller inflammatory reactions, and wound-size reduction was much greater than in the control throughout the inspection period. Mean time in days for 90% healing from sericin-treated wounds was also much less than for cream base-treated wounds. Histological examination after 15 d of treatment with 8% sericin cream revealed complete healing, no ulceration, and an increase in collagen as compared to cream base-treated wounds, which showed some ulceration and acute inflammatory exudative materials.
Aramwit
Pornanong
P
Department of Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand. aramwit@gmail.com
Sangcakul
Areeporn
A
D000287:Administration, Topical; D000818:Animals; D003094:Collagen / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D008297:Male; D009824:Ointments; D011206:Povidone-Iodine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D047030:Sericins / Q000494:pharmacology*; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
D009824:Ointments; D047030:Sericins; D011206:Povidone-Iodine; D003094:Collagen