The use of recombinant human epidermal growth factor to promote healing for chronic radiation ulcer.
This case report describes the first successful use of recombinant human epidermal growth factor (rh-EGF) in radiation-induced chronic wound of bone and skin which remains to be difficult to treat. Such wound on the chest of a 59-year-old female patient is presented lasting 3 years despite flap surgery and conventional treatment. The treatment with rh-EGF achieved healing within 16 weeks but further study to evaluate its potential for radiation-induced chronic wounds is warranted.
Lee
Sang-wook
SW
Department of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
Moon
Sue Young
SY
Kim
Yeun Hwa
YH
Hong
Joon Pio
JP
D001943:Breast Neoplasms / Q000532:radiotherapy; D002908:Chronic Disease; D004815:Epidermal Growth Factor / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011832:Radiation Injuries / Q000150:complications / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D014456:Ulcer / Q000188:drug therapy* / Q000209:etiology; D014945:Wound Healing
D011994:Recombinant Proteins; D004815:Epidermal Growth Factor