[Functional state of serotoninergic system on a background of different pharmacokinetic of Midazolam].
A comprehensive investigation of the high-performance liquid chromatographic separation of Midazolam and his ozidized metabolits, their bases and other low-molecular-weight UV-absorbing compounds that might be found in serum is reported. The drug was administrated (2,0mg/kg) to 40 white mouses and the blood samples were collecetd for further analysis followind 30, 60, 90, 120 and 180 min. after the injection. The serotoninergic systems has been analyzed. Quantitative data were calculated by inner standart method. Oxidazed forms of Midazolam were qualitatively and quantitatively identified. Our data proved the ability of Midazolam to adsorb on the albumin and globulin fraction of plasma. Metabolism of serotonin and triptopchan is closely dependent on the concentration of psychotropic drug. Concentration of aminoacids (triptophan, tirosyn) in the blood is synshronized with the course of pharmacokinetic of the psychotropic preparation and functional state of serotoninergic system. Alterations may be due, on the one hand, to exhaustion of the stores, and on the other hand, to deterioration of the monoamines' synthesis process. The investigation of pharmacokinetics of invariable form of Midazolam and its oxidized metabolits is very important for practical medicine. Effective action of pshychotropic drugs is impossible without extensive knowlege of their phramacokinetics and pharmacodynamics. They are concerned with the need to dermine concentration in body fluids.
Kapanadze
L R
LR
Zurabashvili
Z A
ZA
Arveladze
M N
MN
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D018757:GABA Modulators / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008874:Midazolam / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*
D018757:GABA Modulators; D012701:Serotonin; D008874:Midazolam