title: Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen.
abstract: The purpose of the present research was to produce a quick/slow biphasic delivery system for ibuprofen. A dual-component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (ibuprofen). The sustained release effect was achieved with a polymer (hydroxypropyl methylcellulose [HPMC] or ethylcellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the ibuprofen contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (approximately 16 or >24 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the HPMC core was suitable for providing a constant and controlled release (zero order) for a long period of time.
authors.affiliation: Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal. clopes@ff.up.pt
authors.forename: Carla Martins
authors.initials: CM
authors.lastname: Lopes
authors.forename: José M Sousa
authors.initials: JM
authors.lastname: Lobo
authors.forename: João F
authors.initials: JF
authors.lastname: Pinto
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Costa
mesh_terms: D016503:Drug Delivery Systems; D065347:Hypromellose Derivatives; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives; D012995:Solubility; D013607:Tablets
chemical_list: D013607:Tablets; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D007052:Ibuprofen