title: The effect of glutamine supplementation and physical exercise on neutrophil function.
abstract: Glutamine is the most abundant free amino acid in the body. Its primary source is skeletal muscle, from where it is released into the bloodstream and transported to a variety of tissues. Several studies have shown that glutamine is important for rat and human neutrophil function and that these cells utilize glutamine at high rates. Physical exercise has also been shown to induce considerable changes in neutrophil metabolism and function. As neutrophils represent 50-60% of the total circulating leukocyte pool and play a key role in inflammation, both physical exercise and glutamine might be expected to regulate the inflammatory process. In this review, the changes in neutrophil function induced by physical exercise and glutamine supplementation are compared.
authors.affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil. lagranha@hotmail.com
authors.forename: C J
authors.initials: CJ
authors.lastname: Lagranha
authors.forename: A C
authors.initials: AC
authors.lastname: Levada-Pires
authors.forename: D F
authors.initials: DF
authors.lastname: Sellitti
authors.forename: J
authors.initials: J
authors.lastname: Procopio
authors.forename: R
authors.initials: R
authors.lastname: Curi
authors.forename: T C
authors.initials: TC
authors.lastname: Pithon-Curi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D019587:Dietary Supplements; D015444:Exercise / Q000502:physiology*; D005973:Glutamine / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
chemical_list: D005973:Glutamine