Impairment of recognition memory in interleukin-6 knock-out mice.
We have used transgenic male mice not expressing interleukin-6 (IL-6) [C57BL/6J(IL-6/-tm Kopf)] in object recognition test to assess the role of endogenous IL-6 in recognition memory. Wild-type controls showed better memory than IL-6 knock-out mice. Results of our experiment suggest that endogenous IL-6 may play an important role in the process of recognition memory in mice.
Hryniewicz
Anna
A
Department of General and Experimental Pathology Medical University of Bialystok Mickiewicza 2c, 15-222 Bialystok, Poland. annah@amb.edu.pl
Bialuk
Izabela
I
Kamiński
Karol A
KA
Winnicka
Maria M
MM
D000818:Animals; D005260:Female; D015850:Interleukin-6 / Q000235:genetics* / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011597:Psychomotor Performance / Q000187:drug effects; D021641:Recognition, Psychology / Q000502:physiology*
D015850:Interleukin-6