Cellulitis revealing a cryptococcosis-related immune reconstitution inflammatory syndrome in a renal allograft recipient.
Immune reconstitution inflammatory syndrome (IRIS) has rarely been described in the course of disseminated cryptococcosis in solid organ transplant recipients. We report here the case of a renal transplant recipient who developed severe cellulitis in the context of Cryptococcus neoformans-associated IRIS while undergoing reduction of his immunosuppressive therapy. IRIS appeared concomitantly with a dramatic increase of blood CD4+ T cells (94-460/mm(3)) and required the administration of a short-term steroid therapy to resolve.
Lanternier
F
F
Service des Maladies Infectieuses et Tropicales Hôpital Necker-Enfants Malades, Université Paris V Centre d'Infectiologie Necker-Pasteur, Paris, Cedex 15, France.
Chandesris
M-O
MO
Poirée
S
S
Bougnoux
M-E
ME
Mechai
F
F
Mamzer-Bruneel
M-F
MF
Viard
J-P
JP
Galmiche-Rolland
L
L
Lecuit
M
M
Lortholary
O
O
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002481:Cellulitis / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology*; D003453:Cryptococcosis / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D003455:Cryptococcus neoformans / Q000276:immunology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D014184:Transplantation, Homologous
D000305:Adrenal Cortex Hormones; D000935:Antifungal Agents; D007166:Immunosuppressive Agents