title: Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study.
abstract: BACKGROUND
  Ovarian hyperstimulation syndrome (OHSS) is a result of ovarian overexpression of vascular endothelial growth factor (VEGF) and its receptor 2 (VEGFR2). VEGF/VEGFR2 binding disrupts cellular junctions and increases vascular permeability (VP), a characteristic of OHSS, but enhances angiogenesis, which is a fundamental step in implantation. In animals, the dopamine agonist Cabergoline (Cb2) prevents VP without affecting angiogenesis. In humans, Cb2 averts OHSS, but a possible detrimental effect on angiogenesis and implantation has not been explored. A pilot study was designed to analyze whether or not Cb2 administration, as a procedure for preventing OHSS, affects the outcome of assisted reproduction treatment (ART).
  
  
  METHODS
  A retrospective study with endpoints of implantation and ongoing/term pregnancy rates. Women (n = 35) at risk of OHSS (20-30 follicles developed and >20 oocytes collected) took a daily oral dose of 0.5 mg Cb2 for 8 days, beginning on the day of hCG. They were matched with controls treated during the same period and who were similar with respect to age, number and quality of the embryos replaced, embryonic stage at transfer and sperm quality.
  
  
  RESULTS
  No difference was detected between the groups in fertilization, implantation or pregnancy rates. A total of 14 ongoing (beyond 32 weeks) or full term pregnancies were registered in each group. No major problem was detected during pregnancy or after delivery in any of these babies.
  
  
  CONCLUSIONS
  Administration of Cb2 in order to prevent OHSS is safe and does not appear to affect ART outcome.
authors.affiliation: Instituto Valenciano de Infertilidad (IVI), University of Valencia, Plaza de la Policía Local, 3, 46015 Valencia, Spain.
authors.forename: Claudio
authors.initials: C
authors.lastname: Alvarez
authors.forename: Isabel
authors.initials: I
authors.lastname: Alonso-Muriel
authors.forename: Gabriela
authors.initials: G
authors.lastname: García
authors.forename: Juana
authors.initials: J
authors.lastname: Crespo
authors.forename: José
authors.initials: J
authors.lastname: Bellver
authors.forename: Carlos
authors.initials: C
authors.lastname: Simón
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellicer
mesh_terms: D000328:Adult; D000077465:Cabergoline; D018491:Dopamine Agonists / Q000008:administration & dosage*; D010064:Embryo Implantation / Q000187:drug effects*; D004873:Ergolines / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D010865:Pilot Projects; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies
chemical_list: D018491:Dopamine Agonists; D004873:Ergolines; D000077465:Cabergoline