Gamma 2 actin gene (enteric type) polymorphism is not associated with obstetric cholestasis or preeclampsia.
OBJECTIVE
To determine whether genetic variability in the intron 1 region of the gamma 2 actin gene (enteric type) contributes to the development of obstetric complications.


METHODS
The study involved 57 obstetric cholestasis and 133 preeclampsia patients and a control group of 115 healthy women in whom polymerase chain reaction detection of insertion-deletion polymorphism in the gamma 2 actin gene was investigated. Chi(2) analysis was used to assess genotype and allele frequency differences between the study groups.


RESULTS
The distribution of I and D alleles was equal in obstetric cholestasis (p = 0.652), preeclampsia (p = 0.609) and control groups. None of the gamma 2 actin gene genotypes were significantly overrepresented in obstetric cholestasis (p = 0.540) or preeclampsia (p = 0.680) groups compared to the control group.


CONCLUSIONS
This insertion-deletion polymorphism in the intron 1 of the gamma 2 actin gene is unlikely to play any significant role in obstetric cholestasis or preeclampsia in patients from eastern Finland.
Laasanen
Jaana
J
Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland.
Helisalmi
Seppo
S
Iivonen
Susan
S
Eloranta
M-L
ML
Hiltunen
Mikko
M
Heinonen
Seppo
S
D000199:Actins / Q000235:genetics*; D000328:Adult; D002779:Cholestasis / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D016254:Mutagenesis, Insertional; D011110:Polymorphism, Genetic / Q000235:genetics*; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D012189:Retrospective Studies; D017384:Sequence Deletion
D000199:Actins