title: Effects of stimulant medications on the EEG of girls with Attention-Deficit/Hyperactivity Disorder.
abstract: OBJECTIVE
  Stimulant medications are the most commonly used treatments for Attention-Deficit/Hyperactivity Disorder (AD/HD) in North America and Australia, although it is still not entirely known how these medications work. This study investigated the effects of stimulant medications on the EEG of girls with AD/HD.
  
  
  METHODS
  An initial EEG was recorded during an eyes-closed resting condition. Data from 19 electrode sites were Fourier transformed to provide absolute and relative power estimates for the delta, theta, alpha and beta bands. The data were then averaged into 9 regions and an analysis of both global and regional differences was performed. Subjects were placed on a six-month trial of a stimulant and a second EEG was recorded at the end of the trial.
  
  
  RESULTS
  The unmedicated girls had significantly greater total power, absolute delta and theta, more relative theta especially in the frontal regions, and reduced frontal relative delta and beta activity compared with controls. Medication resulted in normalisation of theta power, but after medication, increased relative beta was also apparent in the AD/HD group.
  
  
  CONCLUSIONS
  These results indicate that stimulant medications result in a normalisation of slow wave activity in the EEG. In line with published research on the effects of arousal on the EEG, these results suggest that stimulant medications may have their therapeutic effect by improving the EEG substrate of processing deficits in these children. However, this requires further testing during active processing tasks.
  
  
  CONCLUSIONS
  This is the first study to investigate the effect of stimulant medications on the EEG of girls with AD/HD.
authors.affiliation: Brain & Behaviour Research Institute and School of Psychology, University of Wollongong, Wollongong, Australia. adam_clarke@uow.edu.au
authors.forename: Adam R
authors.initials: AR
authors.lastname: Clarke
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Barry
authors.forename: Rory
authors.initials: R
authors.lastname: McCarthy
authors.forename: Mark
authors.initials: M
authors.lastname: Selikowitz
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Johnstone
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000513:Alpha Rhythm / Q000187:drug effects; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000503:physiopathology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000503:physiopathology; D002648:Child; D003913:Dextroamphetamine / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008774:Methylphenidate / Q000494:pharmacology; D012815:Signal Processing, Computer-Assisted; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D003913:Dextroamphetamine