title: [Structural and functional studies on proteins as potential drug discovery targets].
abstract: Structural biology teaches us about the fundamental nature of biological molecules. Drug design is the most immediate medical application of structural biology. Therefore our studies have been focused on structural and functional studies of human disease-related proteins and proteins essential for the growth and development of pathogenic organisms. The present paper describes 1) structural biological studies of human autocrine motility factor, 2) structural biological studies of human ribonuclease L, and 3) structural biological studies of Plasmodium falciparum S-adenosyl- L-homocysteine hydrolase.
authors.affiliation: School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. ntanaka@pharm.showa-u.ac.jp
authors.forename: Nobutada
authors.initials: N
authors.lastname: Tanaka
mesh_terms: D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000502:physiology*; D000818:Animals; D018360:Crystallography, X-Ray; D015195:Drug Design; D004722:Endoribonucleases / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000502:physiology*; D005956:Glucose-6-Phosphate Isomerase / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D010963:Plasmodium falciparum / Q000201:enzymology*; D011487:Protein Conformation
chemical_list: D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease; D043383:Adenosylhomocysteinase; D005956:Glucose-6-Phosphate Isomerase