title: A new, powerful glycosylation method: activation of thioglycosides with dimethyl disulfide-triflic anhydride.
abstract: Dimethyl disulfide reacts with triflic anhydride to provide a highly reactive electrophile. Various thioglycosides, differing in their thio aglycons, carbohydrate units, and protecting group pattern, were activated with Me2S2-Tf2O in the presence of different glycosyl acceptors. The reactions proceeded at low temperatures within a short time, affording oligosaccharides in high yields both on primary and secondary hydroxyls. Armed and disarmed glycosyl donors were activated equally efficiently.
authors.affiliation: Department of Carbohydrate Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri út 59-67, H-1025 Budapest, Hungary.
authors.forename: Janos
authors.initials: J
authors.lastname: Tatai
authors.forename: Péter
authors.initials: P
authors.lastname: Fügedi