title: A Prospective longitudinal evaluation of quality of life after abdominoperineal resection.
abstract: OBJECTIVE
  Abdominoperineal resection (APR) is a disfiguring procedure, frequently associated with significant urogenital dysfunction. The aim of this prospective study was to repeatedly assess quality of life (QoL) 1, 6, and 12 months after APR.
  
  
  METHODS
  Twenty patients who underwent APR between June 2002 and September 2005 were considered for analysis. QoL was assessed using two self-rating validated questionnaires developed by the European Organization for Research and Treatment of Cancer (EORTC).
  
  
  RESULTS
  All patients were free of recurrence at time of last interview. At 1-year follow-up patients reported significant improvement in global QoL [scores: 53 +/- 23 (1 month) vs. 70 +/- 15 (1 year), P = 0.01], and physical function (74 +/- 16 vs. 91 +/- 12, P = 0.001). Patients also reported significant improvement in symptoms such as fatigue (39 +/- 30 vs. 15 +/- 19, P = 0.01); and pain (33 +/- 31 vs. 10 +/- 14, P = 0.01). By contrast, there was no improvement at 1 year for the following items: body image (75 +/- 33 vs. 75 +/- 30, P = 0.99), sexual dysfunction (10 +/- 21 vs. 21 +/- 27, P = 0.40); and stoma-related problems (19 +/- 14 vs. 11 +/- 28, P = 0.34).
  
  
  CONCLUSIONS
  One year after APR, patients demonstrated significant improvement in global QoL and tumor-related symptoms, while body image remained significantly altered. Similarly, treatment-related side effects did not improve over the time period considered.
authors.affiliation: Department of Surgery, University Hospital Geneva, Geneva, Switzerland. pascal.gervaz@hcuge.ch
authors.forename: Pascal
authors.initials: P
authors.lastname: Gervaz
authors.forename: Pascal
authors.initials: P
authors.lastname: Bucher
authors.forename: Béatrice
authors.initials: B
authors.lastname: Konrad
authors.forename: Philippe
authors.initials: P
authors.lastname: Morel
authors.forename: Sonia
authors.initials: S
authors.lastname: Beyeler
authors.forename: Laurence
authors.initials: L
authors.lastname: Lataillade
authors.forename: Abdelkarim
authors.initials: A
authors.lastname: Allal
mesh_terms: D000005:Abdomen / Q000601:surgery; D000230:Adenocarcinoma / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010502:Perineum / Q000601:surgery; D011446:Prospective Studies; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000523:psychology* / Q000601:surgery*