The future of vaccines in the management of addictive disorders.
Conventional substance abuse treatments have had only limited success. As a result, new approaches, including vaccination to block the effects of drugs such as cocaine, nicotine, methamphetamine, and phencyclidine, are in development. Although a number of possible rationales for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism would involve binding of the drug by antibodies in the bloodstream, thereby blocking entry or reducing the rate of entry of the drug into the central nervous system. The theoretical parameters that would influence vaccine-induced drug pharmacodynamics are presented in this review, along with the current status on vaccine development for nicotine, cocaine, methamphetamine, and phencyclidine.
Orson
Frank M
FM
Veterans Administration Medical Center, 2002 Holcombe, Houston, TX 77030, USA. forson@bcm.tmc.edu
Kinsey
Berma M
BM
Singh
Rana A K
RA
Wu
Yan
Y
Gardner
Tracie
T
Kosten
Thomas R
TR
D019138:Antibodies, Blocking / Q000276:immunology; D000915:Antibody Affinity / Q000276:immunology; D002986:Clinical Trials as Topic; D005544:Forecasting; D006801:Humans; D013287:Illicit Drugs / Q000276:immunology; D019966:Substance-Related Disorders / Q000276:immunology / Q000534:rehabilitation*; D014612:Vaccines / Q000276:immunology / Q000627:therapeutic use*
D019138:Antibodies, Blocking; D013287:Illicit Drugs; D014612:Vaccines