title: Continuous hemodiafiltration during cardiopulmonary bypass in infants.
abstract: The homologous blood prime in cardiopulmonary bypass circuits contributes a significant electrolyte and metabolite load in small infants. The efficacy of hemofiltration and continuous hemodiafiltration of the blood prime in preventing metabolic disturbances in small infants was compared in two groups of 60 patients each. Blood pH, base excess, and calcium concentrations decreased during cardiopulmonary bypass in the hemofiltration group. The acid-base balance was well preserved during cardiopulmonary bypass by continuous hemodiafiltration. This therapeutic strategy may confer an advantage in maintaining more physiological conditions during cardiopulmonary bypass in small infants.
authors.affiliation: First Department of Surgery, University of Toyama, School of Medicine, 2630 Sugitani, Toyama 930-0194, Japan. ynaoki@med.u-toyama.ac.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Yoshimura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Oshima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Murakami
authors.forename: Hironori
authors.initials: H
authors.lastname: Matsuhisa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamaguchi
mesh_terms: D000137:Acid-Base Imbalance / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D002118:Calcium / Q000097:blood; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D006330:Heart Defects, Congenital / Q000097:blood / Q000401:mortality / Q000601:surgery*; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007231:Infant, Newborn; D019344:Lactic Acid / Q000097:blood; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood; D012189:Retrospective Studies; D013997:Time Factors; D014883:Water-Electrolyte Imbalance / Q000097:blood / Q000209:etiology / Q000517:prevention & control*
chemical_list: D019344:Lactic Acid; D011188:Potassium; D002118:Calcium