title: Vaccinations in disease models with antibody-dependent enhancement.
abstract: This paper examines the effects of single-strain vaccine campaigns on the dynamics of an epidemic multistrain model with antibody-dependent enhancement (ADE). ADE is a disease spreading process causing individuals with their secondary infection to be more infectious than during their first infection by a different strain. We follow the two-strain ADE model described in Cummings et al. [D.A.T. Cummings, Doctoral Thesis, Johns Hopkins University, 2004] and Schwartz et al. [I.B. Schwartz, L.B. Shaw, D.A.T. Cummings, L. Billings, M. McCrary, D. Burke, Chaotic desynchronization of multi-strain diseases, Phys. Rev. E, 72:art. no. 066201, 2005]. After describing the model and its steady state solutions, we modify it to include vaccine campaigns and explore if there exists vaccination rates that can eradicate one or more strains of a virus with ADE.
authors.affiliation: Montclair State University, Department of Mathematical Sciences, Montclair, NJ 07043, USA. billingsl@mail.montclair.edu
authors.forename: Lora
authors.initials: L
authors.lastname: Billings
authors.forename: Amy
authors.initials: A
authors.lastname: Fiorillo
authors.forename: Ira B
authors.initials: IB
authors.lastname: Schwartz
mesh_terms: D019067:Antibody-Dependent Enhancement; D003715:Dengue / Q000276:immunology / Q000517:prevention & control; D053059:Dengue Vaccines / Q000276:immunology; D003716:Dengue Virus / Q000276:immunology; D018448:Models, Immunological; D014611:Vaccination
chemical_list: D053059:Dengue Vaccines