Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and update.
A roundtable consensus meeting was held to consolidate current knowledge on the etiology of colorectal cancer in patients with inflammatory bowel disease and to review current strategies, both diagnostic and preventive, specifically addressing the role of 5-aminosalicylic acid. Specific topics that were addressed included: the epidemiology of colorectal cancer, including an assessment of risk factors and the impact of colonoscopy on colorectal cancer incidence and mortality; the origin and evolution of dysplasia nomenclature and the natural history of dysplasia; review of the experience of St. Mark's Hospital (London) as gleaned from its surveillance database; mechanisms by which 5-aminosalicylic acid is thought to exert a chemopreventive effect; the potential future role of 5-aminosalicylic acid in chemopreventive strategies; chemoprevention in familial adenomatous polyposis; and other future research directions. This article provides a comprehensive overview of the issues discussed and should act as a guide to shaping the design of future studies in this area.
Rubin
David T
DT
University of Chicago Medical Center, Chicago, IL 60637, USA. drubin@medicine.bsd.uchicago.edu
Cruz-Correa
Marcia R
MR
Gasche
Christoph
C
Jass
Jeremy R
JR
Lichtenstein
Gary R
GR
Montgomery
Elizabeth A
EA
Riddell
Robert H
RH
Rutter
Matthew D
MD
Ullman
Thomas A
TA
Velayos
Fernando S
FS
Itzkowitz
Steven
S
D011125:Adenomatous Polyposis Coli / Q000150:complications / Q000188:drug therapy; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D019804:Mesalamine / Q000494:pharmacology / Q000627:therapeutic use*; D011230:Precancerous Conditions / Q000473:pathology; D015995:Prevalence; D009626:Terminology as Topic
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine