title: Prognostic significance of gastrin expression in patients undergoing R0 gastrectomy for adenocarcinoma.
abstract: BACKGROUND
  Gastrointestinal (GI) hormones regulate several GI functions, including the proliferation and repair of normal mucosa, and hormone receptors may therefore be implicated in the growth, invasion, and metastasis of cancers of the GI tract. The aim of this study was to determine the cellular distribution of gastrin in intestinal-type gastric cancers, and to determine its relationship to outcomes after R0 gastrectomy.
  
  
  METHODS
  Eighty-six consecutive patients undergoing R0 gastrectomy for adenocarcinoma were studied. Normal gastric mucosa and tumor were stained for gastrin and their specific cellular distribution was determined.
  
  
  RESULTS
  The duration of survival of patients whose tumors exhibited well-differentiated gastrin-positive tumor (GPT) cells (n = 12) was significantly poorer than that of patients whose tumors were GPT-negative (5-year survival, 30% vs 54%; P = 0.037). Patients with GPT-positive intestinal-type gastric cancer (5 of 47 patients) had the poorest survival of all (median, 14 months; 5-year survival, 0%; P = 0.006). In a multivariate analysis, only lymph node metastases (hazard ratio [HR], 2.13; 95% confidence interval [CI], 1.2 to 3.79; P = 0.01) and the presence of GPT cells (HR, 6.61; 95% CI, 1.74 to 25.09; P = 0.01) were independently and significantly associated with durations of survival in patients with intestinal-type gastric cancer.
  
  
  CONCLUSIONS
  The presence of GPT cells in patients with gastric adenocarcinoma is a significant and independent prognostic indicator.
authors.affiliation: Department of Surgery, Royal Gwent Hospital, Newport, UK.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Stephens
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Hopper
authors.forename: Wyn G
authors.initials: WG
authors.lastname: Lewis
authors.forename: Guy
authors.initials: G
authors.lastname: Blackshaw
authors.forename: Paul
authors.initials: P
authors.lastname: Edwards
authors.forename: Becky
authors.initials: B
authors.lastname: Osborne
authors.forename: Ian W
authors.initials: IW
authors.lastname: Thompson
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D005260:Female; D005743:Gastrectomy; D005755:Gastrins / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate
chemical_list: D005755:Gastrins