title: Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis.
abstract: Strontium ranelate reduces the risk of fracture in post-menopausal osteoporotic women with prevalent fractures for whom quality of life is severely impaired. The SOTI study, which used the SF-36 questionnaire and disease-specific QUALIOST module, demonstrated that treatment with strontium ranelate improved osteoporotic women's quality of life compared with placebo.
  
  
  BACKGROUND
  The Spinal Osteoporosis Therapeutic Intervention (SOTI) study demonstrated the effect of orally administered strontium ranelate versus placebo on the incidence of new vertebral fractures and compared impact on quality of life (QoL).
  
  
  METHODS
  QoL was assessed 6 monthly over 3 years using the QUALIOST and SF-36 questionnaires in post-menopausal osteoporotic women with prevalent fracture taking strontium ranelate or placebo 2 g/day. A total of 1,240 women were included (strontium ranelate: n=618 and placebo: n=622).
  
  
  RESULTS
  The QUALIOST total score decreased in the strontium ranelate group, indicating preserved QoL compared with a deterioration in the placebo group (P=0.016). Strontium ranelate patients had reduced QUALIOST emotional and physical dimension scores (P=0.019 and 0.032, respectively, versus placebo), indicating beneficial effects on emotional and physical functioning. There was a trend towards better SF-36 scores in the strontium ranelate group, although there were no significant between-group differences. More strontium ranelate patients (+31%) were free from back pain over 3 years versus placebo (P=0.005), with a significant effect from the first year of treatment (P=0.023).
  
  
  CONCLUSIONS
  Strontium ranelate has beneficial effects on QoL in women with post-menopausal osteoporosis compared with placebo.
authors.affiliation: Mapi Values, 15 Court Square Suite 620, Boston, MA 02108, USA. patrick.marquis@mapivalues.com
authors.forename: P
authors.initials: P
authors.lastname: Marquis
authors.forename: C
authors.initials: C
authors.lastname: Roux
authors.forename: C
authors.initials: C
authors.lastname: de la Loge
authors.forename: M
authors.initials: M
authors.lastname: Diaz-Curiel
authors.forename: C
authors.initials: C
authors.lastname: Cormier
authors.forename: G
authors.initials: G
authors.lastname: Isaia
authors.forename: J
authors.initials: J
authors.lastname: Badurski
authors.forename: J
authors.initials: J
authors.lastname: Wark
authors.forename: P J
authors.initials: PJ
authors.lastname: Meunier
mesh_terms: D000328:Adult; D015519:Bone Density / Q000187:drug effects* / Q000502:physiology; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D005260:Female; D050723:Fractures, Bone / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D008875:Middle Aged; D009942:Organometallic Compounds / Q000627:therapeutic use*; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy* / Q000503:physiopathology; D011788:Quality of Life / Q000523:psychology; D016103:Spinal Fractures / Q000517:prevention & control*; D013876:Thiophenes / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate