Biological investigation of 131I-labeled new water soluble Ru(II) polypyridyl complex.
New [Ru(L1)(dcbpy)(NCS)2] complex was synthesized in a one-pot reaction starting from [RuCl2(p-cymene)]2, where the ligands (dcbpy=4,4'-dicarboxy-2,2'-bipyridine, L1=dipyrido[3,2-a:2',3'-c]phenazine-11-ylcarbonyl)-sodium) are introduced sequentially. The resulting complex was characterized by IR, NMR, and elemental analysis. The complex was labeled with I-131. Biodistribution study of the complex was carried out using 131I-labeled [Ru(L1)(dcbpy)(NCS)2] complex. The biodistribution study performed with albino Wistar male rats has shown that the complex has high uptake in the lung, small intestine, fat, and spleen.
Ocakoglu
Kasim
K
Solar Energy Institute, Department of Chemistry, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey. kasim.ocakoglu@ege.edu.tr
Yildirim
Yeliz
Y
Yurt Lambrecht
Fatma
F
Ocal
Jale
J
Icli
Siddik
S
D000818:Animals; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D008297:Male; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D010777:Photochemistry; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012428:Ruthenium / Q000493:pharmacokinetics*; D012995:Solubility; D014018:Tissue Distribution; D014867:Water
D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D011725:Pyridines; D019275:Radiopharmaceuticals; D014867:Water; D012428:Ruthenium