Radical scavenging activity of Trianthema triquetra in male albino rats intoxicated with CCl4.
Radical scavenging activity of ethanolic extract of Trianthema triquetra root was investigated against CCl4 in rats. The rats were treated with T. triquetra (100 mg, 200 mg/kg b.w.) for a period of 7 days. Antihepatotoxic effect was studied by assaying the activities of thiobarbituric acid (TBARS), reduced glutathione (GSH), glutathione peroxidase (GPx),catalase (CAT), super oxide dismutase (SOD) and vitamin C (Vit. C). Lipid peroxidation is evidenced by an increase in the value of TBARS and also a distinct diminution in the level of GSH, Vit. C at 200 mg/kg b.w. The activity of antioxidant enzymes, such as GPx, CAT SOD and Vit. E is significantly recovered towards an almost normal level in animals coadministrated with T. triquetra. The maximum protection against CCl4 induced hepatic injury was afforded by the dose of 200 mg/kg b.w. of Trianthema triquetra.
Chitra
M
M
P.G. Department of Biochemistry, S.T.E.T. Women's College, Mannargudi 614 001, India. Srianuman21@yahoo.co.in
Nithyanandhi
K
K
D035722:Aizoaceae / Q000737:chemistry*; D000818:Animals; D001205:Ascorbic Acid / Q000097:blood; D002251:Carbon Tetrachloride; D002374:Catalase / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D000431:Ethanol / Q000737:chemistry; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D005978:Glutathione / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000097:blood
D016166:Free Radical Scavengers; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D000431:Ethanol; D002251:Carbon Tetrachloride; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione; D001205:Ascorbic Acid