title: Multicenter trials need to use the same assay for hepatitis C virus viral load determination.
abstract: This study, involving 20 laboratories and using currently available assays for hepatitis C virus RNA quantification, demonstrated that differences in viral load values are due not to interlaboratory variations but rather to the nature of the assay itself. This underlines the importance of using the same assay in multicenter studies or when monitoring antiviral therapy.
authors.affiliation: Centre National de Référence pour les Hépatites B et C en Transfusion, Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, 6 rue Alexandre-Cabanel, 75015, Paris, France.
authors.forename: Syria
authors.initials: S
authors.lastname: Laperche
authors.forename: Françoise
authors.initials: F
authors.lastname: Bouchardeau
authors.forename: Vincent
authors.initials: V
authors.lastname: Thibault
authors.forename: Bruno
authors.initials: B
authors.lastname: Pozzetto
authors.forename: Sophie
authors.initials: S
authors.lastname: Vallet
authors.forename: Arielle R
authors.initials: AR
authors.lastname: Rosenberg
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Roque-Afonso
authors.forename: Michèle
authors.initials: M
authors.lastname: Gassin
authors.forename: Françoise
authors.initials: F
authors.lastname: Stoll-Keller
authors.forename: Pascale
authors.initials: P
authors.lastname: Trimoulet
authors.forename: Elyanne
authors.initials: E
authors.lastname: Gault
authors.forename: Bruno
authors.initials: B
authors.lastname: Chanzy
authors.forename: Bernard
authors.initials: B
authors.lastname: Mercier
authors.forename: Michel
authors.initials: M
authors.lastname: Branger
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Pawlotsky
authors.forename: Cécile
authors.initials: C
authors.lastname: Henquell
authors.forename: Françoise
authors.initials: F
authors.lastname: Lunel
authors.forename: Catherine
authors.initials: C
authors.lastname: Gaudy-Graffin
authors.forename: Sophie
authors.initials: S
authors.lastname: Alain
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Chaix
authors.forename: Gilles
authors.initials: G
authors.lastname: Duverlie
authors.forename: Jacques
authors.initials: J
authors.lastname: Izopet
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Lefrère
mesh_terms: D016174:Hepacivirus / Q000302:isolation & purification*; D006801:Humans; D015337:Multicenter Studies as Topic / Q000379:methods*; D012367:RNA, Viral / Q000032:analysis*; D019562:Viral Load
chemical_list: D012367:RNA, Viral