Evaluation of the CTSL2 gene as a candidate gene for alopecia X in Pomeranians and Keeshonden.
Alopecia X is a noninflammatory, progressive, bilateral symmetric alopecia in dogs. The disease is mainly found in Nordic breeds. The breed predisposition and a strong familial accumulation suggest a hereditary background. We analyzed the cathepsin L2 gene (CTSL2) as a candidate for alopecia X. The comparative sequencing of 14 affected and 18 control animals revealed ten polymorphisms; however, none of these polymorphisms affected the coding sequence. Haplotype analysis did not reveal an association of one particular CTSL2 haplotype with the disease phenotype; therefore, we conclude that the CTSL2 gene is probably not the causative gene for alopecia X.
Mausberg
E-M
EM
Institute of Genetics, DermFocus, Vetsuisse Faculty of the University of Berne, Berne, Switzerland.
Drögemüller
C
C
Leeb
T
T
Dolf
G
G
Rüfenacht
S
S
Welle
M
M
D000505:Alopecia / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D056668:Cathepsin L; D002403:Cathepsins / Q000235:genetics*; D003546:Cysteine Endopeptidases / Q000235:genetics*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005260:Female; D006239:Haplotypes; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011110:Polymorphism, Genetic; D016415:Sequence Alignment
D004247:DNA; D002403:Cathepsins; D003546:Cysteine Endopeptidases; D056668:Cathepsin L