title: Leufolins A and B, potent butyrylcholinesterase-inhibiting flavonoid glucosides from Leucas urticifolia.
abstract: New flavonoidal glucosides leufolins A (1) and B (2), have been isolated from the ethyl acetate soluble fraction of the whole plants of Leucas urticifolia. Their structures were elucidated on the basis of extensive analysis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Both of these compounds exhibited significant inhibitory potential against the enzyme butyrylcholinesterase.
authors.affiliation: International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.lastname: Atia-tun-Noor
authors.forename: Itrat
authors.initials: I
authors.lastname: Fatima
authors.forename: Ijaz
authors.initials: I
authors.lastname: Ahmad
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Nighat
authors.initials: N
authors.lastname: Afza
authors.forename: Lubna
authors.initials: L
authors.lastname: Iqbal
authors.forename: Mehreen
authors.initials: M
authors.lastname: Latif
authors.forename: Sher Bahadar
authors.initials: SB
authors.lastname: Khan
mesh_terms: D027703:Amaranthaceae / Q000737:chemistry*; D002091:Butyrylcholinesterase / Q000378:metabolism*; D002247:Carbon Isotopes; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D011522:Protons
chemical_list: D002247:Carbon Isotopes; D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D005960:Glucosides; D011522:Protons; C523807:leufolin A; C523808:leufolin B; D002091:Butyrylcholinesterase