Assessment of the content of phenolics and antioxidant actions of the Rubiaceae, Ebenaceae, Celastraceae, Erythroxylaceae and Sterculaceae families of Mauritian endemic plants.
There is continued interest in the assessment of the bioefficacy of the active principles in extracts from a variety of traditional medicine and food plants in order to determine their impact on the management of a variety of clinical conditions and maintenance of health. The polyphenolic composition and antioxidant potential of Mauritian endemic plants of the Rubiaceae, Ebenaceae, Celastraceae, Erythroxylaceae and Sterculaceae family were determined. The phenolics level of the plant extracts varied from 1 to 75 mg/g FW, the maximum level measured in Diospyros neraudii (Ebenaceae). Coffea macrocarpa showed the highest flavonoids content with 18+/-0.7 mg/g FW. The antioxidant capacity based on the TEAC and FRAP values were strongly related to total phenolics and proanthocyanidins content, while a weaker correlation was observed with (-) gallic acid. Erythroxylum sideroxyloides showed the highest protective effect in the lipid peroxidation systems with IC(50) of 0.0435+/-0.001 mg FW/ml in the Fe(3+)/ascorbate system and 0.05+/-0.002 mg FW/ml in the AAPH system. Cassine orientalis, E. sideroxyloides, Diospyros mellanida and Chassalia coriancea var. johnstonii were weakly prooxidant only at higher concentration greater of 10 g FW/L indicating potential safety. Mauritian endemic plants, particularly the genus Diospyros, are good sources of phenolic antioxidants and potential candidates for the development of prophylactic agents.
Soobrattee
Muhammad A
MA
Department of Biosciences, Faculty of Science, University of Mauritius, Réduit, Mauritius.
Bahorun
Theeshan
T
Neergheen
Vidushi S
VS
Googoolye
Kreshna
K
Aruoma
Okezie I
OI
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D002417:Cattle; D029753:Celastraceae / Q000737:chemistry; D031262:Ebenaceae / Q000737:chemistry; D030921:Erythroxylaceae / Q000737:chemistry; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005707:Gallic Acid / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation; D019660:Malvaceae / Q000737:chemistry; D008436:Mauritius; D008862:Microsomes, Liver; D010636:Phenols / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D059808:Polyphenols; D044945:Proanthocyanidins / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D019666:Rubiaceae / Q000737:chemistry
D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D044945:Proanthocyanidins; D005707:Gallic Acid