title: Clinicopathological features of primary cutaneous B-cell lymphomas from an academic regional hospital in central Italy: no evidence of Borrelia burgdorferi association.
abstract: We reviewed the clinico-pathological features of 73 primary cutaneous B-cell lymphomas (PCBCLs), diagnosed in 10 years in Marche region in central Italy, which included 16 marginal zone lymphomas (MZL), 33 follicle centre lymphomas (FCL) and 24 diffuse large B cell lymphomas (DLBCL). We also investigated the presence of Borrelia burgdorferi in tissues by polymerase chain reaction. Differences in age, sex, location site, response to therapy, disease recurrence and 5-year disease-specific survival were observed among the 3 histological groups. Specific DNA sequences of Borrelia burgdorferi were not detected in any of the 73 cases of PCBCL. We conclude that PCBCLs in Marche region behave according to the literature data and do not seem to be associated with Borrelia burgdorferi. Additional investigations should be performed on other possible etiologies, at least in our geographical area.
authors.affiliation: Anatomia Patologica, Università Politecnica delle Marche, Ospedali Riuniti di Ancona Umberto I, G.M. Lancisi, G. Salesi, Ancona, Italy. g.goteri@ao-umbertoprimo.marche.it
authors.forename: Gaia
authors.initials: G
authors.lastname: Goteri
authors.forename: Renzo
authors.initials: R
authors.lastname: Ranaldi
authors.forename: Oriana
authors.initials: O
authors.lastname: Simonetti
authors.forename: Roberta
authors.initials: R
authors.lastname: Capretti
authors.forename: Stefano
authors.initials: S
authors.lastname: Menzo
authors.forename: Daniela
authors.initials: D
authors.lastname: Stramazzotti
authors.forename: Doriana
authors.initials: D
authors.lastname: Morichetti
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Offidani
authors.forename: Serena
authors.initials: S
authors.lastname: Rupoli
authors.forename: Pietro
authors.initials: P
authors.lastname: Leoni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D025065:Borrelia burgdorferi / Q000235:genetics / Q000302:isolation & purification*; D004269:DNA, Bacterial / Q000302:isolation & purification; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007558:Italy; D016393:Lymphoma, B-Cell / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology*
chemical_list: D004269:DNA, Bacterial