title: Magnetic resonance perfusion imaging in malformations of cortical development.
abstract: BACKGROUND
  Malformations of cortical development vary in neuronal maturity and level of functioning.
  
  
  OBJECTIVE
  To characterize regional relative cerebral blood volume (rCBV) and difference in first moment transit time (TTfm) in polymicrogyria and cortical tubers using magnetic resonance (MR) perfusion imaging.
  
  
  METHODS
  MR imaging and dynamic T2*-weighted MR perfusion imaging were performed in 13 patients with tuberous sclerosis complex, 10 with polymicrogyria, and 18 controls with developmental delay but no macroscopic brain abnormality. Regions of interest were placed in cortical tubers or polymicrogyric cortex and in the contralateral normal-appearing side in patients with malformations. In "control" subjects, regions of interest were placed in the frontal and parietal lobes in both hemispheres. The rCBV and TTfm of the tuber/contralateral side (rCBV(R)TSC and DeltaTT(FM)TSC) as well as those of the polymicrogyria/contralateral side (rCBV(R)PMG and DeltaTT(FM)PMG) were assessed. The right-to-left asymmetry of rCBV and TTfm in the control group was also assessed (rCBV(R)Controls and DeltaTT(FM)Controls).
  
  
  RESULTS
  There was no significant asymmetry between right and left rCBV or TTfm (P>0.05) in controls. There was significant reduction in rCBV(R)TSC compared to rCBV(R)Controls (P<0.05), but no significant difference in DeltaTT(FM)TSC compared to DeltaTT(FM)Controls (P>0.05). There were no significant differences between rCBV(R)PMG and rCBV(R)Controls (P>0.05) or DeltaTT(FM)PMG and DeltaTT(FM)Controls (P>0.05).
  
  
  CONCLUSIONS
  Our findings imply that cerebral blood volume of polymicrogyria is similar to normal cortex, but there is reduced cerebral blood volume in cortical tubers. The lower rCBV ratio of cortical tubers may be related to known differences in pathogenetic timing of the underlying abnormalities during brain development or the presence of gliosis.
authors.affiliation: Academic Section of Radiology, University of Sheffield, Sheffield, United Kingdom.
authors.forename: E
authors.initials: E
authors.lastname: Widjaja
authors.forename: I D
authors.initials: ID
authors.lastname: Wilkinson
authors.forename: P D
authors.initials: PD
authors.lastname: Griffiths
mesh_terms: D000293:Adolescent; D001810:Blood Volume; D002560:Cerebrovascular Circulation; D054022:Cerebrum / Q000098:blood supply / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D007839:Functional Laterality; D006801:Humans; D007223:Infant; D018810:Magnetic Resonance Angiography; D054220:Malformations of Cortical Development / Q000175:diagnosis* / Q000503:physiopathology*; D014402:Tuberous Sclerosis / Q000175:diagnosis / Q000503:physiopathology