title: Electroreduction of the muscle relaxant drug dantrolene sodium at the mercury electrode and its determination in bulk form and pharmaceutical formulation.
abstract: The electroreduction of the muscle relaxant drug dantrolene sodium at the mercury electrode has been studied in the Britton-Robinson universal buffer of pH 2.5-11.5 containing 20% (v/v) methanol by means of dc-polarography, cyclic voltammetry and controlled-potential coulometry. Its reduction took place via three irreversible cathodic steps in solutions of pH < or =6, two steps in solutions of 6<pH<10 and a single step at pH values > or =10 through the consumption of 10, 8 or 4 electrons, respectively. This behavior was attributed to the reduction of NO(2) group (1st and 2nd steps at pH < or =6 or the single step at pH > or =10) and the -CH=N- double bond (3rd step at pH <10). Two polarographic procedures (direct current and differential-pulse modes) and three adsorptive cathodic stripping voltammetric procedures (linear-sweep, differential-pulse and square-wave modes) were described and successfully applied for quantification of dantrolene sodium in its bulk form and in pharmaceutical formulation (Dantrolex tablets).
authors.affiliation: Chemistry Department, Faculty of Science, Tanta University, Egypt. enassmmghoneim@hotmail.com
authors.forename: Enass Mohamed
authors.initials: EM
authors.lastname: Ghoneim
mesh_terms: D002021:Buffers; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003620:Dantrolene / Q000737:chemistry / Q000494:pharmacology*; D004563:Electrochemistry; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D008628:Mercury / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D009125:Muscle Relaxants, Central / Q000737:chemistry / Q000494:pharmacology*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D019999:Pharmaceutical Solutions / Q000032:analysis / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D018030:Silver Compounds / Q000737:chemistry; D013607:Tablets
chemical_list: D002021:Buffers; D009125:Muscle Relaxants, Central; D004364:Pharmaceutical Preparations; D019999:Pharmaceutical Solutions; D018030:Silver Compounds; D013607:Tablets; D012834:Silver; D003620:Dantrolene; D008628:Mercury; C037548:silver chloride; D000432:Methanol