title: Lichen secondary metabolites from the cultured lichen mycobionts of Teloschistes chrysophthalmus and Ramalina celastri and their antiviral activities.
abstract: Lichens and spore-derived cultured mycobionts of Teloschistes chrysophthalmus and Ramalina celastri were studied chemically, and results indicated that they produced, respectively, parietin and usnic acid as major secondary metabolites, which were purified and identified. Identification of the compounds was performed by high performance liquid chromatography and structural elucidation by nuclear magnetic resonance (1H) and electron impact mass spectrometry. Usnic acid exhibited antiviral activity whereas parietin had a virucidal effect against the arenaviruses Junin and Tacaribe.
authors.affiliation: Laboratorio de Liquenología, Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, (1428) Buenos Aires, Argentin.
authors.forename: Alejandra T
authors.initials: AT
authors.lastname: Fazio
authors.forename: Mónica T
authors.initials: MT
authors.lastname: Adler
authors.forename: María D
authors.initials: MD
authors.lastname: Bertoni
authors.forename: Claudia S
authors.initials: CS
authors.lastname: Sepúlveda
authors.forename: Elsa B
authors.initials: EB
authors.lastname: Damonte
authors.forename: Marta S
authors.initials: MS
authors.lastname: Maier
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D002851:Chromatography, High Pressure Liquid; D004642:Emodin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000882:Haplorhini; D008011:Lichens / Q000737:chemistry* / Q000254:growth & development*; D013170:Spores / Q000502:physiology; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D001572:Benzofurans; C073339:usnic acid; C008905:physcione; D004642:Emodin