title: Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia.
abstract: Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia rarely occur concurrently. We report a case in which these disorders were associated with an occult large granular lymphocyte leukemia. The peripheral blood cytopenias improved after glucocorticoids and intravenous immunoglobulin were administered, and response was maintained with cyclosporine. Large granular lymphocyte leukemia should be suspected in the setting of unexplained bone marrow failure.
authors.affiliation: VA Greater Los Angeles Health Care System, Los Angeles, CA 90095-1678, United States.
authors.forename: Dominic W
authors.initials: DW
authors.lastname: Lai
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Loughran
authors.forename: Jaroslaw P
authors.initials: JP
authors.lastname: Maciejewski
authors.forename: Sebastian
authors.initials: S
authors.lastname: Sasu
authors.forename: Sophie X
authors.initials: SX
authors.lastname: Song
authors.forename: P K
authors.initials: PK
authors.lastname: Epling-Burnette
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Paquette
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D005260:Female; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D011696:Purpura, Thrombocytopenic / Q000150:complications*; D011971:Receptors, Immunologic / Q000032:analysis; D012010:Red-Cell Aplasia, Pure / Q000150:complications*; D000071176:Signaling Lymphocytic Activation Molecule Family
chemical_list: D015703:Antigens, CD; C084093:CD244 protein, human; D011971:Receptors, Immunologic; D000071176:Signaling Lymphocytic Activation Molecule Family