Adrenomedullin reduces the severity of cerulein-induced acute pancreatitis.
We investigated the effect of Adrenomedullin (AM) on cerulein-induced acute pancreatitis in rats. AM treatment (100 ng/kg per rat, subcutaneous) after one hour of cerulein injection reduced the plasma amylase levels, pancreatic weight, pancreatic malondialdehyde (MDA) levels, and the severity of the lesions microscopically. These data suggest that AM has a protective effect on cerulein-induced acute pancreatitis. These could be due to anti-inflammatory properties of AM, inhibition of proinflammatory cytokine secretion, reducing the endothelial permeability increased by reactive oxygen species, endotoxins or cytokines.
Onur
Ozge Ecmel
OE
Department of Emergency Medicine, Marmara University School of Medicine, Istanbul, Turkey. ozberkozge@gmail.com
Guneysel
Ozlem
O
Akoglu
Haldun
H
Denizbasi
Arzu
A
Onur
Ender
E
D000208:Acute Disease; D053607:Adrenomedullin / Q000008:administration & dosage / Q000494:pharmacology*; D000681:Amylases / Q000378:metabolism; D000818:Animals; D002108:Ceruletide / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007279:Injections, Subcutaneous; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
D053607:Adrenomedullin; D008315:Malondialdehyde; D002108:Ceruletide; D000681:Amylases