title: The use of miniature supersonic nozzles for microparticle acceleration: a numerical study.
abstract: By means of a high-speed gas flow generated by a miniature supersonic nozzle, we proposed a unique biolistic method to accelerate microparticle formulation of drugs to sufficient momentum, to penetrate the outer layer of human skin or mucosal tissue for the treatment of a range of diseases. One of the main concerns for designing and evaluating this system is ensuring microparticles delivery into human skin with a controllable velocity range and spatial distribution. The initial experimental work suggested that the performance of the transdermal delivery strongly depends on aerodynamics of the supersonic nozzles employed. In this paper, computational fluid dynamics (CFD) is utilized to characterize existing prototype biolistic delivery systems, the device with a converging-diverging supersonic nozzle (CDSN) and the device based on the contoured-shock-tube (CST) design, with the aim at investigating the transient gas and particle dynamics in the supersonic nozzles. Whenever possible, predicted pressure and Mach number histories, 2-D flow structures, and particle velocity distributions are made to compare with the corresponding experimental measurements to validate the implemented numerical approach. The gas-particle interaction and performance of two biolistic devices are interrogated and distinguished. Subsequently, the particle impact conditions are presented and discussed. It is demonstrated that the CST can deliver microparticles with a narrow and more controllable velocity range and spatial distribution.
authors.affiliation: Oxford Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, 43 Banbury Road, Oxford OX2 6PE, UK. yi.liu@eng.ox.ac.uk
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
mesh_terms: D003198:Computer Simulation; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007277:Injections, Jet / Q000295:instrumentation* / Q000379:methods; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods; D008863:Microspheres; D008904:Miniaturization; D008962:Models, Theoretical; D010316:Particle Size