title: Neuroscience: a local route to pain relief.
authors.forename: Edwin W
authors.initials: EW
authors.lastname: McCleskey
mesh_terms: D000772:Anesthesia, Local / Q000379:methods; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D002463:Cell Membrane Permeability; D004553:Electric Conductivity; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives / Q000494:pharmacology; D009619:Nociceptors / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D026941:Sodium Channel Blockers / Q000378:metabolism* / Q000494:pharmacology*; D050916:TRPV Cation Channels / Q000378:metabolism*
chemical_list: D000779:Anesthetics, Local; D026941:Sodium Channel Blockers; D050916:TRPV Cation Channels; C493922:Trpv1 protein, rat; C012647:QX-314; D008012:Lidocaine; D012964:Sodium; D002211:Capsaicin