[The regulation of mast cell migration. Part 1: cell adhesion molecules].
Mast cells take part in multiple pathological processes, in some of which mast cell accumulation is central to pathogenesis. They are also vital factors in many physiological reactions. Therefore it seems to be of great importance to understand the mechanisms underlying mast cell migration into and within tissues. There are many factors that regulate the migration of mast cell progenitors from the blood into tissues and the migration of mature mast cells within tissues, leading to the rapid local accumulation that occurs in diverse pathological conditions. Without any doubt, cell-surface adhesion molecules are central to the migratory process, as they facilitate the binding of cells to extracellular matrix (ECM) proteins. Immature and mature mast cells express different adhesion molecules, especially integrins, that are involved in mast cell adhesion to such ECM proteins as laminin, fibronectin, vitronectin, and collagens. The expression of adhesion molecules alters during mast cell development and maturation. What is more, mast cell adhesion molecule expression and mast cell adhesion to ECM proteins may be regulated by some cytokines.
Misiak-Tłoczek
Anna
A
Zakład Immunologii Doświadczalnej, Uniwersytet Medyczny w Łodzi.
Brzezińska-Błaszczyk
Ewa
E
D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D002465:Cell Movement / Q000502:physiology*; D003094:Collagen / Q000096:biosynthesis; D016207:Cytokines / Q000096:biosynthesis; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005353:Fibronectins / Q000096:biosynthesis; D015870:Gene Expression; D006801:Humans; D016023:Integrins / Q000096:biosynthesis; D007797:Laminin / Q000096:biosynthesis; D008407:Mast Cells / Q000502:physiology*; D015854:Up-Regulation; D019096:Vitronectin / Q000096:biosynthesis
D015815:Cell Adhesion Molecules; D016207:Cytokines; D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D016023:Integrins; D007797:Laminin; D019096:Vitronectin; D003094:Collagen