title: Patient sensitivity to polyethylene particles with cemented total hip arthroplasty.
abstract: To determine whether sensitivity to polyethylene particles varies among patients, we studied 25 patients who had undergone total hip arthroplasty. We used pelvic radiographs to measure annual polyethylene wear and the area of osteolysis. The ratio of the area of osteolysis to the volumetric polyethylene wear was defined as sensitivity index. Adherent cells from peripheral blood were cocultured with polyethylene particles, and the amount of bone-resorptive cytokines was measured. The amount of interleukin-6, but not of interleukin-1beta or tumor necrosis factor-alpha, released from adherent cells in the in vitro experiment correlated with the in vivo sensitivity indices. This technique appears capable of predicting the development of polyethylene-induced osteolysis, allowing surgeons to avoid using polyethylene as the bearing surface in patients at risk for osteolysis.
authors.affiliation: Department of Orthopaedic Surgery, Kyoto University, Kyoto, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ise
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kawanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsusaki
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Shimizu
authors.forename: Eijiro
authors.initials: E
authors.lastname: Onishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects* / Q000379:methods; D001843:Bone Cements; D001862:Bone Resorption / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D005500:Follow-Up Studies; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D015850:Interleukin-6 / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D008863:Microspheres; D008875:Middle Aged; D010014:Osteolysis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D020959:Polyethylene / Q000009:adverse effects*; D011859:Radiography
chemical_list: D001843:Bone Cements; D015850:Interleukin-6; D020959:Polyethylene