[Prevention and treatment of nonsteroidal anti-inflammatory drugs induced ulcers].
There are many randomized controlled trials (RCTs) about prevention and treatment for nonsteroidal anti-inflammatory drugs (NSAIDs) induced ulcers in the world. Prevention and treatment about NSAIDs induced ulcers by proton pump inhibitors (PPIs) and misoprostol are well established. Cyclooxygenase (COX)-2 inhibitors reduce ulcers but some reports revealed that these drugs increased cardiovascular adverse events than conventional NSAIDs. In Japan, there are few RCTs about NSAIDs induced ulcers. The approved dosages of NSAIDs are much fewer in Japan than in the United States and Western countries. So it is necessary to study about efficacy and safety of PPIs and misoprostol for Japanese patients and clear the most appropriate dosages of these drugs and distinguish the high risk patients.
Kobayakawa
Masao
M
Department of Gastroenterology, International Medical Center of Japan.
Uemura
Naomi
N
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000188:drug therapy* / Q000517:prevention & control; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D054328:Proton Pump Inhibitors; D016595:Misoprostol