Synthesis and hydrothermal treatment of nanostructured hydroxyapatite of controllable sizes.
Nanoparticulate systems have been studied for targeted and controlled release of therapeutic agents; and size is one of the major determinants of their in vivo clearance kinetics by the MPS macrophages. As such, it is important to control the size of hydroxyapatite nanoparticles during synthesis. The results show that the size of hydroxyapatite nanoparticles, synthesized through chemical precipitation, increases with increasing synthesis time. Particle sizes were also observed to increase in a linear correlation with temperature. Crystallinity and carbonate-substitution of the nanoparticles also increased with temperature. Hydrothermal, performed as a post-synthesis treatment, improves particle morphology, giving particles with regular surface contours, well-defined sizes and lower particle agglomeration. By controlling synthesis temperature and time, hydroxyapatite nanoparticles with well-defined sizes and morphology can be obtained.
Loo
Say Chye Joachim
SC
School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore. joachimloo@ntu.edu.sg
Siew
Yiwei Eva
YE
Ho
Shuhui
S
Boey
Freddy Yin Chiang
FY
Ma
J
J
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D011232:Chemical Precipitation; D003460:Crystallization; D017886:Durapatite / Q000138:chemical synthesis* / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry; D010316:Particle Size; D013499:Surface Properties; D013696:Temperature; D013997:Time Factors; D014867:Water / Q000494:pharmacology*; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D014867:Water; D017886:Durapatite