title: Oxygen-sensitive 3He-MRI in bronchiolitis obliterans after lung transplantation.
abstract: Oxygen-sensitive 3He-MRI was studied for the detection of differences in intrapulmonary oxygen partial pressure (pO2) between patients with normal lung transplants and those with bronchiolitis obliterans syndrome (BOS). Using software developed in-house, oxygen-sensitive 3He-MRI datasets from patients with normal lung grafts (n = 8) and with BOS (n = 6) were evaluated quantitatively. Datasets were acqiured on a 1.5-T system using a spoiled gradient echo pulse sequence. Underlying diseases were pulmonary emphysema (n = 10 datasets) and fibrosis (n = 4). BOS status was verified by pulmonary function tests. Additionally, 3He-MRI was assessed blindedly for ventilation defects. Median intrapulmonary pO2 in patients with normal lung grafts was 146 mbar compared with 108 mbar in patients with BOS. Homogeneity of pO2 distribution was greater in normal grafts (standard deviation pO2 34 versus 43 mbar). Median oxygen decrease rate during breath hold was higher in unaffected patients (-1.75 mbar/s versus -0.38 mbar/s). Normal grafts showed fewer ventilation defects (5% versus 28%, medians). Oxygen-sensitive 3He-MRI appears capable of demonstrating differences of intrapulmonary pO2 between normal lung grafts and grafts affected by BOS. Oxygen-sensitive 3He-MRI may add helpful regional information to other diagnostic techniques for the assessment and follow-up of lung transplant recipients.
authors.affiliation: Klinik und Poliklinik für diagnostische und interventionelle Radiologie, Klinikum der Johannes Gutenberg-Universität, Langenbeckstrasse 1, 55131 Mainz, Germany. kgast@radiologie.klinik.uni-mainz.de
authors.forename: Klaus Kurt
authors.initials: KK
authors.lastname: Gast
authors.forename: Alexander
authors.initials: A
authors.lastname: Biedermann
authors.forename: Annette
authors.initials: A
authors.lastname: Herweling
authors.forename: Wolfgang Günter
authors.initials: WG
authors.lastname: Schreiber
authors.forename: Jörg
authors.initials: J
authors.lastname: Schmiedeskamp
authors.forename: Eckhard
authors.initials: E
authors.lastname: Mayer
authors.forename: Claus Peter
authors.initials: CP
authors.lastname: Heussel
authors.forename: Klaus
authors.initials: K
authors.lastname: Markstaller
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
authors.forename: Balthasar
authors.initials: B
authors.lastname: Eberle
mesh_terms: D000328:Adult; D001989:Bronchiolitis Obliterans / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006371:Helium; D006801:Humans; D016040:Lung Transplantation; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis*; D010313:Partial Pressure; D012189:Retrospective Studies
chemical_list: D006371:Helium; D010100:Oxygen