[Protective effect of Sankang Capsule on immunity-deficiency mice induced by cyclophosphamide].
OBJECTIVE
To study the immunomodulatory effect of Sankang Capsule( SKC) on the immunity-deficiency mice.


METHODS
The immunity-deficiency model was induced by intraperitoneal injection (ip) of cyclophosphamide (CTX) at the dose of 100 mg/ kg in mice which were randomly divided into normal control group, immunity-deficiency model group, SKC treated group (250 mg/kg, 500 mg/kg) and positive control group (500 mg/kg). The number of WBC in peripheral blood, the weight of immune organs, the phagocytosis activity of macrophage, the content of serum hemolysin and the proliferation of T lymphocyte in the spleen were measured.


RESULTS
The number of WBC, the weight of immune organs, the phagocytosis activity of macrophage, the content of serum hemolysin and the proliferation of T lymphocyte in the model group were all decreased compared with those of normal control group. After the administration of SKC, the index mentioned above was increased compared with those of model group.


CONCLUSIONS
SKC has a protective effect on the immunity-deficiency mice, which may be related to the increasing of cellular immunity, humoral immunity and nonspecific immunity.
Zhang
Xu
X
Pharmaceutical College, Lanzhou University, Lanzhou 730000, China. zhangxucq@126.com
Zhang
Ru-Xue
RX
Tu
Hong-Hai
HH
Jia
Zheng-Ping
ZP
Li
Mao-Xing
MX
Wang
Juan
J
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002214:Capsules; D003520:Cyclophosphamide / Q000633:toxicity; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006460:Hemolysin Proteins / Q000097:blood; D007109:Immunity / Q000187:drug effects*; D016867:Immunocompromised Host / Q000187:drug effects* / Q000276:immunology; D007166:Immunosuppressive Agents / Q000633:toxicity; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D010586:Phagocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D013154:Spleen / Q000187:drug effects / Q000473:pathology
D000276:Adjuvants, Immunologic; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006460:Hemolysin Proteins; D007166:Immunosuppressive Agents; C530156:sankang; D003520:Cyclophosphamide