title: A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.
abstract: To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 (involved in TGF-beta and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research, Sutton SM2 5NG, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Broderick
authors.forename: Luis
authors.initials: L
authors.lastname: Carvajal-Carmona
authors.forename: Alan M
authors.initials: AM
authors.lastname: Pittman
authors.forename: Emily
authors.initials: E
authors.lastname: Webb
authors.forename: Kimberley
authors.initials: K
authors.lastname: Howarth
authors.forename: Andrew
authors.initials: A
authors.lastname: Rowan
authors.forename: Steven
authors.initials: S
authors.lastname: Lubbe
authors.forename: Sarah
authors.initials: S
authors.lastname: Spain
authors.forename: Kate
authors.initials: K
authors.lastname: Sullivan
authors.forename: Sarah
authors.initials: S
authors.lastname: Fielding
authors.forename: Emma
authors.initials: E
authors.lastname: Jaeger
authors.forename: Jayaram
authors.initials: J
authors.lastname: Vijayakrishnan
authors.forename: Zoe
authors.initials: Z
authors.lastname: Kemp
authors.forename: Maggie
authors.initials: M
authors.lastname: Gorman
authors.forename: Ian
authors.initials: I
authors.lastname: Chandler
authors.forename: Elli
authors.initials: E
authors.lastname: Papaemmanuil
authors.forename: Steven
authors.initials: S
authors.lastname: Penegar
authors.forename: Wendy
authors.initials: W
authors.lastname: Wood
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Sellick
authors.forename: Mobshra
authors.initials: M
authors.lastname: Qureshi
authors.forename: Ana
authors.initials: A
authors.lastname: Teixeira
authors.forename: Enric
authors.initials: E
authors.lastname: Domingo
authors.forename: Ella
authors.initials: E
authors.lastname: Barclay
authors.forename: Lynn
authors.initials: L
authors.lastname: Martin
authors.forename: Oliver
authors.initials: O
authors.lastname: Sieber
authors.forename: David
authors.initials: D
authors.lastname: Kerr
authors.forename: Richard
authors.initials: R
authors.lastname: Gray
authors.forename: Julian
authors.initials: J
authors.lastname: Peto
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Cazier
authors.forename: Ian
authors.initials: I
authors.lastname: Tomlinson
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D051906:Smad7 Protein / Q000235:genetics*
chemical_list: C497806:SMAD7 protein, human; D051906:Smad7 Protein