Excess leucine intake induces serine dehydratase in rat liver.
We have hypothesized that rat liver serine dehydratase (SDH) is induced in response to the amount of surplus amino acids from dietary protein. In the present study, we found that excess leucine intake strongly induced SDH activity in the liver but not in the kidney of rats. The increase in activity was accompanied by increases in the levels of SDH mRNA. On the other hand, isoleucine and valine had little effect on SDH induction. These results support our hypothesis and suggest that leucine is a signal for SDH induction.
Zhong
Bo
B
Department of Biological Resource Chemistry, Kyoto Prefectural University, Japan.
Sakai
Shunsuke
S
Saeki
Tohru
T
Kanamoto
Ryuhei
R
D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D012695:L-Serine Dehydratase / Q000096:biosynthesis* / Q000235:genetics*; D007930:Leucine / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D004044:Dietary Proteins; D012333:RNA, Messenger; D012695:L-Serine Dehydratase; D007930:Leucine