title: Risk of Clostridium difficile-associated disease among patients receiving proton-pump inhibitors in a Quebec medical intensive care unit.
abstract: Our study was conducted to determine whether use of gastric acid-suppressive agents increased the risk of Clostridium difficile-associated disease (CDAD) in a medical intensive care unit of one of the first hospitals to be threatened by the current CDAD epidemic in Quebec, Canada. Our findings suggest that efforts to determine risk factors for CDAD should focus on other areas, such as older age and antibiotic use.
authors.affiliation: Faculty of Pharmacy, Universite de Montreal, Montreal, QC, H3C 3J7, Canada. mathieu.beaulieu@umontreal.ca
authors.forename: Mathieu
authors.initials: M
authors.lastname: Beaulieu
authors.forename: David
authors.initials: D
authors.lastname: Williamson
authors.forename: Gilbert
authors.initials: G
authors.lastname: Pichette
authors.forename: Jean
authors.initials: J
authors.lastname: Lachaine
mesh_terms: D018806:APACHE; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D016360:Clostridioides difficile; D015331:Cohort Studies; D004761:Enterocolitis, Pseudomembranous / Q000145:classification / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008297:Male; D054328:Proton Pump Inhibitors; D011792:Quebec / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors