title: Effects of different nutritional support on lung mechanics and remodelling in undernourished rats.
abstract: This study investigated the impact of three different oral nutritional support regimens on lung mechanics and remodelling in young undernourished Wistar rats. In the nutritionally deprived group, rats received one-third of their usual daily food consumption for 4 weeks. Undernourished rats were divided into three groups receiving a balanced, glutamine-supplemented, or long-chain triglyceride-supplemented diet for 4 weeks. In the two control groups, rats received food ad libitum for 4 (C4) or 8 weeks. Lung viscoelastic pressure and static elastance were higher in undernourished compared to C4 rats. After refeeding, lung mechanical data remained altered except for the glutamine-supplemented group. Undernutrition led to a reduced amount of elastic and collagen fibres in the alveolar septa. Elastic fibre content returned to control with balanced and glutamine-supplemented diets, but increased with long-chain triglyceride-supplemented diet. The amount of collagen fibre augmented independent of nutritional support. In conclusion, glutamine-supplemented diet is better at reducing morphofunctional changes than other diets after 4 weeks of refeeding.
authors.affiliation: Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Ilha do Fundão, 21949-900 Rio de Janeiro, Brazil.
authors.forename: Cristina M
authors.initials: CM
authors.lastname: Dias
authors.forename: Caroline P
authors.initials: CP
authors.lastname: Pássaro
authors.forename: Mariana A
authors.initials: MA
authors.lastname: Antunes
authors.forename: Viviane R
authors.initials: VR
authors.lastname: Cagido
authors.forename: Marcelo
authors.initials: M
authors.lastname: Einicker-Lamas
authors.forename: Jennifer
authors.initials: J
authors.lastname: Lowe
authors.forename: Elnara M
authors.initials: EM
authors.lastname: Negri
authors.forename: Nilsa R
authors.initials: NR
authors.lastname: Damaceno-Rodrigues
authors.forename: Roseli
authors.initials: R
authors.lastname: Soncini
authors.forename: Vera L
authors.initials: VL
authors.lastname: Capelozzi
authors.forename: Walter A
authors.initials: WA
authors.lastname: Zin
authors.forename: Patricia R M
authors.initials: PR
authors.lastname: Rocco
mesh_terms: D000818:Animals; D015153:Blotting, Western; D001835:Body Weight / Q000502:physiology; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D003094:Collagen / Q000502:physiology; D004328:Drive; D004548:Elasticity; D005652:Functional Residual Capacity / Q000502:physiology; D005973:Glutamine / Q000494:pharmacology; D008055:Lipids / Q000737:chemistry; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D044342:Malnutrition / Q000178:diet therapy / Q000503:physiopathology*; D046529:Microscopy, Electron, Transmission; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D018529:Nutritional Support; D011506:Proteins / Q000737:chemistry; D011650:Pulmonary Alveoli / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D015656:Respiratory Mechanics / Q000502:physiology*; D012132:Respiratory Muscles / Q000187:drug effects / Q000503:physiopathology; D014280:Triglycerides / Q000494:pharmacology
chemical_list: D008055:Lipids; D011506:Proteins; D014280:Triglycerides; D005973:Glutamine; D003094:Collagen