Experimental antegrade enema. Effects on water, electrolyte and acid-base balances with different solutions.
OBJECTIVE
To study the effects on the water, electrolyte, and acid-base balances in rabbits submitted to antegrade enema with different solutions through appendicostomy.


METHODS
Forty male New Zealand rabbits were submitted to appendicostomy, and distributed in 4 groups, according to the antegrade enema solution: PEG group, polyethylene glycol electrolyte solution (n=10); ISS group, isotonic saline solution (n=10); GS group, glycerin solution (n=10); SPS group, sodium phosphate solution (n=10). After being weighed, arterial blood gas analysis, red blood count, creatinine and electrolytes were measured at 4 times: preoperatively (T1); day 6 postop, before enema (T2); 4h after enema (T3); and 24h after T3 (T4).


RESULTS
In PEG group occurred Na retention after 4h, causing alkalemia, sustained for 24h with HCO3 retention. In ISS group occurred isotonic water retention and hyperchloremic acidosis after 4h, which was partially compensated in 24h. GS group showed metabolic acidosis after 4h, compensated in 24h. In SPS group occurred hypernatremic dehydration, metabolic acidosis in 4h, and hypokalemia, hypocalcemia, hypomagnesemia, and metabolic alkalosis with partially compensated dehydration in 24h.


CONCLUSIONS
All solutions used in this study caused minor alterations on water, electrolyte or acid-base balances. The most intense ones were caused by hypertonic sodium phosphate solution (SPS) and isotonic saline solution (ISS) and the least by polyethyleneglycol electrolyte solution (PEG) and glycerin solution 12% (GS).
Helman
Laura
L
Pediatric Department, Faculty of Medicine, Federal University of Uberlândia, Minas Gerais, Brazil. helman@ufu.br
Martins
José Luiz
JL
Fagundes
Djalma José
DJ
Esteves
Edward
E
Lima
Cirilo de Paula
Cde P
Costa
Alisson de Souza
Ade S
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000137:Acid-Base Imbalance / Q000097:blood / Q000209:etiology; D000818:Animals; D001065:Appendix / Q000601:surgery; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects; D004733:Enema / Q000009:adverse effects / Q000379:methods*; D005990:Glycerol / Q000008:administration & dosage / Q000009:adverse effects*; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000009:adverse effects; D008275:Magnesium Deficiency / Q000097:blood / Q000209:etiology; D008297:Male; D023421:Models, Animal; D010710:Phosphates / Q000008:administration & dosage / Q000009:adverse effects*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000009:adverse effects*; D011817:Rabbits; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects*; D014883:Water-Electrolyte Imbalance / Q000097:blood / Q000209:etiology
D002400:Cathartics; D007552:Isotonic Solutions; D010710:Phosphates; D011092:Polyethylene Glycols; D005990:Glycerol; C018279:sodium phosphate