title: The potential role of innate immunity in the pathogenesis of Hodgkin's lymphoma.
abstract: The innate immune system is our first line of defense against danger signals but in Hodgkin's lymphoma the role seems opposite, favoring malignant development. In this article we describe interactions between Hodgkin's and Reed-Sternberg cells and the cells of the innate immune system: eosinophils, mast cells, neutrophils, and macrophages. These cells clearly contribute to the pathogenesis of this disease and to the prognosis. Cytokines and chemokines released from the activated immune cells probably promote tumor cell growth and survival along with angiogenesis. Mast cells and eosinophils seem also to contribute to the fibrosis that is so characteristic for nodular sclerosis.
authors.affiliation: Department of Oncology, Radiology, and Clinical Immunology, Section of Oncology, Uppsala University Hospital, Rudbeck Laboratory C11, S-75185 Uppsala, Sweden. Gunilla.Enblad@onkologi.uu.se
authors.forename: Gunilla
authors.initials: G
authors.lastname: Enblad
authors.forename: Daniel
authors.initials: D
authors.lastname: Molin
authors.forename: Ingrid
authors.initials: I
authors.lastname: Glimelius
authors.forename: Marie
authors.initials: M
authors.lastname: Fischer
authors.forename: Gunnar
authors.initials: G
authors.lastname: Nilsson
mesh_terms: D004804:Eosinophils / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology* / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D019899:Paracrine Communication; D016539:Reed-Sternberg Cells / Q000276:immunology