Bioactive phenols from the leaves of Baccaurea ramiflora.
Two new phenols, 6'- O-vanilloylisotachioside ( 1) and 6'- O-vanilloyltachioside ( 2), together with nine known compounds, were isolated from the leaves of Baccaurea ramiflora (Euphorbiaceae). The structures of the new compounds were elucidated mainly by analysis of physical and spectroscopic data. Compounds 1 - 10 were tested for antioxidant activities by using MTT and DPPH assays. Seven compounds, 1, 2, and 4 - 8, revealed potent antioxidant activities against H (2)O (2)-induced impairment in PC12 cells, and exhibited significant DPPH radical-scavenging activities with IC (50) values of 86.9, 142.9, 15.2, 37.6, 35.9, 30.2, and 79.8 microM, respectively.
Yang
Xian-Wen
XW
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
Wang
Jun-Song
JS
Ma
Yan-Lin
YL
Xiao
Hai-Tao
HT
Zuo
Yi-Qing
YQ
Lin
Hua
H
He
Hong-Ping
HP
Li
Ling
L
Hao
Xiao-Jiang
XJ
D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001713:Biphenyl Compounds; D002478:Cells, Cultured; D019665:Euphorbiaceae; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D010636:Phenols / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl