Substandard application of preimplantation genetic screening may interfere with its clinical success.
The intent of this study was to evaluate a recent randomized clinical trial evaluating the effect of preimplantation genetic screening (PGS) that reports a negative effect on pregnancy outcome. This article reviews appropriate PGS techniques and how they differ from the trial in question. A closer look at the clinical trial in question reveals significant lack of expertise in biopsy, cell fixation, genetic analysis, and patient selection. At most, this trial demonstrates that in inexperienced hands, PGS can be detrimental. No other conclusions concerning the effect of PGS on pregnancy results can be drawn from the trial.
Munné
Santiago
S
Reprogenetics, Livingston, New Jersey 07039, USA. munne@reprogenetics.com
Gianaroli
Luca
L
Tur-Kaspa
Ilan
I
Magli
Cristina
C
Sandalinas
Mireia
M
Grifo
Jamie
J
Cram
David
D
Kahraman
Semra
S
Verlinsky
Yury
Y
Simpson
Joe L
JL
D000026:Abortion, Habitual / Q000628:therapy; D001706:Biopsy / Q000592:standards; D005260:Female; D005821:Genetic Techniques / Q000592:standards; D006801:Humans; D018579:Patient Selection; D011247:Pregnancy; D011256:Pregnancy Outcome; D019836:Preimplantation Diagnosis / Q000592:standards*; D016032:Randomized Controlled Trials as Topic / Q000592:standards