title: Systemic lupus erythematosus: new molecular targets.
abstract: T cells from patients with systemic lupus erythematosus exhibit a notable array of defects that probably contribute to the origin and development of the disease. Such abnormalities include an abnormal response to stimulation, aberrant expression of molecules that play key roles in intracellular signalling pathways, altered transcription factor activation and binding, and skewed gene expression. The combination of these alterations leads the cell to the expression of a particular phenotype that intense research has gradually uncovered over the last years. The aim of this article is to review the findings that have allowed us to better understand the behaviour of the lupus T cell and highlight the molecules that represent potential therapeutic targets.
authors.affiliation: Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, 4 Blackfan Circle, HIM-244, Boston, MA 02115, USA.
authors.forename: José C
authors.initials: JC
authors.lastname: Crispín
authors.forename: Vasileios
authors.initials: V
authors.lastname: Kyttaris
authors.forename: Yuang-Taung
authors.initials: YT
authors.lastname: Juang
authors.forename: George C
authors.initials: GC
authors.lastname: Tsokos
mesh_terms: D017252:CD3 Complex / Q000276:immunology; D002462:Cell Membrane / Q000235:genetics / Q000276:immunology; D002465:Cell Movement / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation / Q000235:genetics / Q000276:immunology; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics / Q000276:immunology; D007376:Interleukin-2 / Q000235:genetics / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology
chemical_list: D017252:CD3 Complex; D018960:Hyaluronan Receptors; D007376:Interleukin-2; D014157:Transcription Factors