Nitric oxide prodrugs: diazeniumdiolate anions of hindered secondary amines.
Nitric oxide prodrugs derived from hindered secondary amines were prepared. The decomposition patterns of these prodrugs indicate that alpha-methyl groups around the nitrogen bearing the diazeniumdiolate group prolong their half-life in aqueous buffer.
Chakrapani
Harinath
H
Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.
Showalter
Brett M
BM
Citro
Michael L
ML
Keefer
Larry K
LK
Saavedra
Joseph E
JE
D000588:Amines / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry*
D000588:Amines; D001391:Azo Compounds; D011355:Prodrugs; C452539:diazeniumdiolate; D009569:Nitric Oxide