p53 and mdm2 expression in colorectal carcinoma: a correlative analysis with clinical staging and histological parameters.
Colorectal carcinoma (CRC) is rare in the Indian subcontinent. The two-hit carcinogenic theory has been well established from the turn of this century, in which p53 is described as a late marker in colorectal carcinogenesis, and murine double minute 2 (mdm2) has not yet been correlated with colorectal carcinoma. With the recent introduction of anti-mdm2 oligonucleotides, it is apparent that if its role can be established in colorectal carcinogenesis, the DNA conservation of the wild p53 strain would be achieved therapeutically because mdm2 conserves the wild p53 strain. We studied 32 cases with adequate number of controls and found a positive correlation (P = .001) between these proteins. These proteins were expressed in tumor adjacent to the hyperplastic mucosa, dysplastic mucosa, and aberrant crypt foci, unlike in studies in the West. The expression of these proteins was correlated with aggressive tumor behavior. All these indicate significant diagnostic, therapeutic, and prognostic roles for these proteins.
Das
Prasenjit
P
Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110 029, India. dr_prasenpgi@yahoo.co.in
Vaiphei
Kim
K
Jain
Deepali
D
Wig
Jai Dev
JD
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2