Antistressor activity of Ocimum sanctum (Tulsi) against experimentally induced oxidative stress in rabbits.
Fresh leaves of Ocimum sanctum (O. sanctum) were evaluated for antistress activity against experimentally induced oxidative stress in albino rabbits. Animals of the test group received supplementation of 2 g fresh leaves of O. sanctum per rabbit for 30 days. Anemic hypoxia was induced chemically by injecting the rabbits with 15 mg sodium nitrite per 100 g body weight intraperitoneally. Results indicated that O. sanctum administration blunted the changes in cardiorespiratory (BP, HR, RR) parameters in response to stress. A significant (p < 0.01) decrease in blood sugar level was observed after 30 days of dietary supplementation of O. sanctum leaves. Significant increase (p < 0.05) in the levels of enzymatic (superoxide dismutase) and nonenzymatic (reduced glutathione) antioxidants was observed in the test group after the treatment with O. sanctum. Oxidative stress led to a lesser depletion of reduced glutathione (28.80%) and plasma superoxide dismutase (23.04%) in O. sanctum-treated rabbits. The results of this study suggest that the potential antistressor activity of O. sanctum is partly attributable to its antioxidant properties.
Jyoti
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Department of Physiology, Pt. B. D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India. dr_jyotisethi@rediffmail.com
Satendra
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Sushma
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Anjana
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Shashi
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D000740:Anemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D019587:Dietary Supplements; D005260:Female; D005978:Glutathione / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D000860:Hypoxia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D031339:Ocimum; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D018515:Plant Leaves; D028321:Plant Preparations / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D012977:Sodium Nitrite; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D001786:Blood Glucose; D028321:Plant Preparations; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione; D012977:Sodium Nitrite