title: [Expression of ARA55 mRNA in prostate carcinoma tissues and its significance].
abstract: OBJECTIVE
  To investigate the expression of ARA55 mRNA in the prostate carcinoma tissues and its clinical significance.
  
  
  METHODS
  Real-time RT-PCR was used to examine the expression of ARA55 mRNA in the samples of the prostate carcinoma tissues from 32 patients.
  
  
  RESULTS
  ARA55 mRNA expressed in different degrees in all the samples. The Ct values were 20.57 +/- 0.20 and 16.33 +/- 0.31 at T1-T2 and T3-T4 stages, 23.13 +/- 0.13 and 17.3 +/- 0.19 for those with Gleason score < or =7 and >7, 24.70 +/- 0.27 and 17.21 +/- 0.34 for those with PSA < or =10 microg/L and >10 microg/L, and 23.82 +/- 0.21 and 16.71 +/- 0.32 for those that responded to endocrinological therapy and those that failed to, respectively. There was a significant difference between the former and the latter.
  
  
  CONCLUSIONS
  ARA55 mRNA expression is significantly correlated with the clinical characteristics of the patient. And ARA55 can be regarded as a prognostic molecular marker for prostate carcinoma as well as a predictor of endocrinological therapeutic effect on the disease.
authors.affiliation: Department of Urology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200001, China.
authors.forename: Nian-qin
authors.initials: NQ
authors.lastname: Yang
authors.forename: Run-sheng
authors.initials: RS
authors.lastname: Li
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Sha
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Yi-xin
authors.initials: YX
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D060588:LIM Domain Proteins; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016896:Treatment Outcome
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; D012333:RNA, Messenger; C490351:TGFB1I1 protein, human