Preparation and properties of mixed micelles made of Pluronic polymer and PEG-PE.
Mixed micelles made of Pluronic P105 (P105) and poly(ethylene glycol)-phosphatidyl ethanolamine conjugate (PEG-PE) were prepared. The interaction of Pluronic and PEG-PE was studied and the interaction parameter beta and critical micelle concentration (CMC) were used to evaluate the micellar stability toward dilution. The results showed that certain mixed micelles were more stable than pure Pluronic micelles upon dilution. The mixed micelles were used to trap the poorly soluble anticancer drug camptothecin (CPT). The cytotoxicity of the CPT-loaded mixed micelles against MCF-7 cancer cell was higher than that of CPT-loaded P105 micelles and much higher than that of the free drug.
Li
Lingbing
L
Department of Pharmaceutics, School of Pharmacy, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong 250012, China. cnlilingbing@yahoo.com
Tan
Ye Bang
YB
D000230:Adenocarcinoma / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008823:Micelles; D010316:Particle Size; D010714:Phosphatidylethanolamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D020442:Poloxamer / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties; D013816:Thermodynamics; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D008823:Micelles; D010714:Phosphatidylethanolamines; D020442:Poloxamer; C067972:dioleoyl-N-(monomethoxypolyethylene glycol succinyl)phosphatidylethanolamine; D011092:Polyethylene Glycols; C519610:pluronic P105