miRNA in embryonic development: the taming of Nodal signaling.
The TGF-beta family member Nodal is one of the most potent molecules known to an embryo. Studies on Nodal regulation thus far have focused on its transcription, maturation, and interaction with antagonists. Two recent studies on the role of microRNAs (miRNAs) in Nodal signaling now reveal that something important was missing from the picture.
Collignon
Jérôme
J
Université Paris 7, Université Paris 6, 75251 Paris cedex 05, France. collignon@ijm.jussieu.fr
D000818:Animals; D019521:Body Patterning; D047108:Embryonic Development; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D055457:Nodal Protein; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000502:physiology*
D035683:MicroRNAs; C526007:NODAL protein, human; D055457:Nodal Protein; D016212:Transforming Growth Factor beta