title: Comparison of optical low coherence reflectometry and ultrasound pachymetry in the measurement of central corneal thickness before and after photorefractive keratectomy.
abstract: OBJECTIVE
  To compare an ultrasound pachymeter with an optical low coherence reflectometry (OLCR) pachymeter for measuring pre- and postoperative central corneal thickness of patients undergoing photorefractive keratectomy (PRK).
  
  
  METHODS
  In a prospective, noncomparative, interventional study, 48 myopic eyes (mean manifest refractive spherical equivalent: -4.93 +/- 2.93 diopters [D]) of 30 healthy patients underwent PRK. Pre- and postoperative central corneal thickness was measured by two examiners (E1, E2) with an ultrasound pachymeter and an OLCR pachymeter. Agreement and inter-rater repeatability were determined using the comparison method described by Bland and Altman.
  
  
  RESULTS
  The limits of agreement between the two devices ranged from 17.8 microm (E1) to 20.5 microm (E2) preoperatively and from 22.4 microm (E1) to 16.9 microm (E2) postoperatively. The coefficient of inter-rater repeatability ranged from 9.1 microm (ultrasound pachymeter) to 5.4 microm (OLCR pachymeter) preoperatively and from 7.1 microm (ultrasound pachymeter) to 4.7 microm (OLCR pachymeter) postoperatively.
  
  
  CONCLUSIONS
  The OLCR pachymeter seems to show better pre- and postoperative repeatability compared to the ultrasound pachymeter. The agreement between the two devices should be considered acceptable for clinical practice. Photorefractive keratectomy did not affect the postoperative agreement and repeatability of the pachymeters.
authors.affiliation: University of L'Aquila, L'Aquila, Italy. lspadea@cc.univaq.it
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Spadea
authors.forename: Daniele
authors.initials: D
authors.lastname: Giammaria
authors.forename: Lucia
authors.initials: L
authors.lastname: Di Genova
authors.forename: Arianna
authors.initials: A
authors.lastname: Fiasca
mesh_terms: D000328:Adult; D003315:Cornea / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D007368:Interferometry; D054018:Lasers, Excimer; D008027:Light; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D015588:Observer Variation; D018903:Photorefractive Keratectomy; D011446:Prospective Studies; D015203:Reproducibility of Results; D014465:Ultrasonics; D014463:Ultrasonography