title: Immunogenicity and safety of pneumococcal 7-valent conjugate vaccine (diphtheria CRM(197) protein conjugate; Prevenar ) in Korean infants: differences that are found in Asian children.
abstract: This study was conducted to determine the immunogenicity and safety of a 7-valent CRM197 protein conjugated pneumococcal vaccine (PCV7) in Korean infants immunized at 2, 4 and 6 months. A total of 202 infants were enrolled and 146 and 141 infants were, respectively, included in post-2nd dose and post-3rd dose immunogenicity evaluations conducted on a per protocol basis. After two and three PCV7 vaccinations, 63.0-98.0 and 97.2-100% of infants achieved an antibody level of >or=0.35microg/mL, respectively, with a lowest against serotype 6B. No vaccination-related serious adverse reactions were observed. Thus, PCV7 appears safe and highly immunogenic in Korean infants, and adopting two doses for a primary series could be a feasible option for facilitating vaccine coverage rate.
authors.affiliation: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Nam-Hee
authors.initials: NH
authors.lastname: Kim
authors.forename: Jina
authors.initials: J
authors.lastname: Lee
authors.forename: Sang Jeong
authors.initials: SJ
authors.lastname: Lee
authors.forename: Hyunju
authors.initials: H
authors.lastname: Lee
authors.forename: Kyung-Hyo
authors.initials: KH
authors.lastname: Kim
authors.forename: Su-Eun
authors.initials: SE
authors.lastname: Park
authors.forename: Hoan-Jong
authors.initials: HJ
authors.lastname: Lee
mesh_terms: D000917:Antibody Formation / Q000276:immunology*; D001208:Asia; D004306:Dose-Response Relationship, Immunologic; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007114:Immunization; D007223:Infant; D007723:Korea / Q000453:epidemiology; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D012449:Safety; D017778:Vaccines, Combined / Q000009:adverse effects / Q000276:immunology; D018074:Vaccines, Conjugate / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines; D017778:Vaccines, Combined; D018074:Vaccines, Conjugate