title: Development of endovascular stent-grafts.
abstract: The very first experiences in the early 1990s with endovascular aortic stent-grafts were associated with significant numbers of complications including an inability to deploy the stent-graft, conversion to open surgery, and aneurysm rupture. By the mid-1990s, improved home-made and commercially available stent-grafts started to appear. These devices could be successfully deployed in the aorta, achieving aneurysm exclusion with low morbidity and mortality. However, follow-up results raised concerns about the longer-term durability. Gradually, too, these problems have been addressed such that, in the recent UK multi-centre randomized controlled trial of endovascular versus open aneurysm repair, aneurysm-related mortality was 3 per cent less in the endovascular group four years following surgery. Currently the indications for aortic stent-grafts are being expanded. It is now possible to maintain perfusion successfully in aortic side branches and to treat aneurysms that would have once been thought untreatable. This review paper reviews the main developments in endovascular stent-grafting and the major role played by medical engineering and technology.
authors.affiliation: Department of Vascular and Endovascular Surgery, University Hospital, Nottingham, UK. robhinchliffe@hotmail.com
authors.forename: R J
authors.initials: RJ
authors.lastname: Hinchliffe
authors.forename: B R
authors.initials: BR
authors.lastname: Hopkinson
mesh_terms: D000783:Aneurysm / Q000601:surgery*; D001807:Blood Vessel Prosthesis / Q000639:trends*; D005544:Forecasting; D006801:Humans; D011474:Prosthesis Design / Q000639:trends*; D015607:Stents / Q000639:trends*