title: [Effect of cortex moutan on PGI2, TXA2, ET and NO in diabetic rats].
abstract: OBJECTIVE
  To study the effect of Paeonol on PGI2, TXA2, ET and NO in diabetic rats.
  
  
  METHODS
  Streptozocin was used on rats to make diabetic animal models. Different dosage of Paeonol were used on diabetic animal models. PGI2, TXA2, ET and NO were tested after 30 days therapy.
  
  
  RESULTS
  Compared with those in the control group, the level of PGI2 increased and the contents of TXA2 and ET decreased in treatment group. Among them, the high dosage group was more obvious (P < 0.01). But the level of No Had no change.
  
  
  CONCLUSIONS
  Paeonol can decrease the ET and TXA2 in diabetic rats, and increase PGI2 in diabetic rats.
authors.affiliation: Guangdong Provincial People's Hospital, Guangzhou 510080, China.
authors.forename: Cun-Yun
authors.initials: CY
authors.lastname: Min
authors.forename: He-Qiang
authors.initials: HQ
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhan
authors.forename: Wei-Zhong
authors.initials: WZ
authors.lastname: Qiu
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D016232:Endothelins / Q000097:blood; D011464:Epoprostenol / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D029596:Paeonia / Q000737:chemistry*; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D013928:Thromboxane A2 / Q000097:blood
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D016232:Endothelins; C038881:moutan cortex; D009569:Nitric Oxide; D013928:Thromboxane A2; D013311:Streptozocin; D011464:Epoprostenol