CYP2A6 gene polymorphism and personality traits for NEO-FFI on the smoking behavior of youths.
We performed a survey on the relationship between nicotine dependence and psychological (the personality traits using neuroticism extroversion openess-five factor inventory (NEO-FFI)/nicotine metabolism (the CYP2A6 gene polymorphism) factors among Japanese young students to elucidate the mechanism of the development of nicotine dependence. As a result, the frequency of the CYP2A6*4C gene (enzyme activity deficit) was significantly (p<0.05) higher among nonsmokers than smokers, and the Openness score by NEO-FFI was higher among smokers than nonsmokers. However, there were no significant differences in the Neuroticism, Extraversion, Agreeableness, and Conscientiousness scores by NEO-FFI between smokers and nonsmokers. We conclude that the CYP2A6*4C gene and the Openness personality trait may affect the development of the smoking behavior of youth.
Waga
Chikako
C
Department of Neurology, Graduate School of Environmental Health, and Azabu University, Kanagawa, Japan.
Iwahashi
Kazuhiko
K
D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D016022:Case-Control Studies; D065637:Cytochrome P-450 CYP2A6; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D008297:Male; D006899:Mixed Function Oxygenases / Q000235:genetics*; D009538:Nicotine / Q000493:pharmacokinetics; D010551:Personality; D010556:Personality Tests; D011110:Polymorphism, Genetic; D012907:Smoking / Q000523:psychology*; D014029:Tobacco Use Disorder / Q000201:enzymology / Q000235:genetics / Q000523:psychology
D009538:Nicotine; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C585710:CYP2A6 protein, human; D065637:Cytochrome P-450 CYP2A6