title: Aminocarbonylation route to tolvaptan.
abstract: Pd-catalyzed aminocarbonylation between aryl bromide and NH-benzazepinone was effectively carried out to furnish the key intermediate for tolvaptan (up to 85%) in one step.
authors.affiliation: Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Naka-Orui, Takasaki, Gunma 370-0033, Japan. torisawa@takasaki-u.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Torisawa
authors.forename: Takuya
authors.initials: T
authors.lastname: Furuta
authors.forename: Takao
authors.initials: T
authors.lastname: Nishi
authors.forename: Shinji
authors.initials: S
authors.lastname: Aki
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Minamikawa
mesh_terms: D001552:Benzazepines / Q000138:chemical synthesis*; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D010165:Palladium / Q000737:chemistry; D000077602:Tolvaptan; D014667:Vasopressins / Q000138:chemical synthesis
chemical_list: D001552:Benzazepines; D014667:Vasopressins; D000077602:Tolvaptan; D010165:Palladium