title: Epithelial myoepithelial carcinoma of the parotid gland with malignant ductal and myoepithelial components arising in a pleomorphic adenoma: a case report with cytologic, histologic and immunohistochemical correlation.
abstract: BACKGROUND
  To describe the cytologic, histologic and immunohistochemical findings of a case of epithelial myoepithelial carcinoma (EMC) arising from a pleomorphic adenoma (PA) of the parotid with both malignant epithelial and myoepithelial components.
  
  
  METHODS
  A 29-year-old female presented with a 1.5 x 1.5-cm, palpable mass of the left parotid of 7-8 months' duration with recent enlargement and pain. Fine needle aspiration biopsy (FNAB) revealed biphasic epithelial (small cell) and myoepithelial (large/clear cell) clusters arranged in a pseudopapillary and trabecular pattern with abundant hyaline material with many naked nuclei, together with areas typical of pleomorphic adenoma (PA) was noted. The cytology was reported as salivary gland neoplasm, "suggestive of adenoid cystic carcinoma, less likely pleomorphic adenoma." The mass was excised and histologically reported as "pleomorphic adenoma, with focal invasion of one resected margin." Four months later the tumor recurred, and FNAB showed almost the same cytologic features as did the previous aspirate. Due to early recurrence, previous histologic sections were reviewed, and typical areas of a biphasic pattern of EMC with atypicality and mitosis of both components was found. The final diagnosis was EMC ex PA.
  
  
  CONCLUSIONS
  Although previous reports mention the difficulties in diagnosing EMC and differentiation from the more common salivary gland neoplasms such as PA, we like to emphasize the cytologic confusion that results when the tumors coexist.
authors.affiliation: Department of Cytopathology, Dr. Daneshbod Pathology Laboratory, Shiraz Medical School, Shiraz, Iran. daneshbk@yahoo.com
authors.forename: Yahya
authors.initials: Y
authors.lastname: Daneshbod
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Negahban
authors.forename: Bijan
authors.initials: B
authors.lastname: Khademi
authors.forename: Khosrow
authors.initials: K
authors.lastname: Daneshbod
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000328:Adult; D002277:Carcinoma / Q000473:pathology*; D002467:Cell Nucleus / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009208:Myoepithelioma / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010307:Parotid Neoplasms / Q000473:pathology*