title: Synthesis of fullerene glycoconjugates via a copper-catalyzed Huisgen cycloaddition reaction.
abstract: The synthesis of fullerene-carbohydrate conjugates using a copper-catalyzed [3+2] cycloaddition reaction to facilitate the union of an azido-functionalized sugar and a pentaalkynyl[60]fullerene is straightforward. Thus, fullerenes bearing five oligosaccharides such as Gb3-trisaccharide can be readily accessed. Nanometer-scale molecular architectures presenting as many as 15 sugar moieties in C5-symmetry are readily produced. The cycloaddition reaction proceeds quantitatively under mild conditions without the need to protect the sugar hydroxyl groups.
authors.affiliation: Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. isobe@mail.tains.tohoku.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Isobe
authors.forename: Kaimei
authors.initials: K
authors.lastname: Cho
authors.forename: Niclas
authors.initials: N
authors.lastname: Solin
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Werz
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nakamura