title: Neuronal glucose sensing: still a physiological orphan?
abstract: Although hypothalamic glucose sensing is a long-established phenomenon, its physiological role remains unclear. New studies (Parton et al., 2007; Claret et al., 2007) disrupting glucose sensing in pro-opiomelanocortin neurons via differing methods have yielded disparate energy and glucose homeostasis phenotypes, suggesting that neuronal glucose sensing is not critical for these processes.
authors.affiliation: Neurology Service, Veterans Affairs Medical Center, East Orange, NJ 07018-1095, USA. levin@umdnj.edu
authors.forename: Barry E
authors.initials: BE
authors.lastname: Levin
mesh_terms: D000818:Animals; D005947:Glucose / Q000378:metabolism*; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D011333:Pro-Opiomelanocortin / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011333:Pro-Opiomelanocortin; D005947:Glucose