title: Myelodysplastic syndromes, aging, and age: correlations, common mechanisms, and clinical implications.
abstract: Myelodysplastic syndromes (MDS) are a heterogenous group of myeloid neoplasms that develop primarily in elderly patients. Although a specific molecular basis for the predominant incidence of MDS in higher age groups remains unknown, several lines of evidence suggest that the biology of aging and the pathogenesis of MDS share several genetic, epigenetic, and molecular features. The current review attempts to delineate these common aspects as well as additional discriminative features that are specific for MDS and thus help explaining disease-evolution and progression. In addition, the present review discusses age as an important prognostic factor and co-variable to be considered in treatment algorithms in MDS.
authors.affiliation: Hanusch Hospital, 3rd Medical Department, Vienna, Austria. michael.pfeilstocker@wgkk.sozvers.at
authors.forename: Michael
authors.initials: M
authors.lastname: Pfeilstöcker
authors.forename: Heidrun
authors.initials: H
authors.lastname: Karlic
authors.forename: Thomas
authors.initials: T
authors.lastname: Nösslinger
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sperr
authors.forename: Reinhard
authors.initials: R
authors.lastname: Stauder
authors.forename: Otto
authors.initials: O
authors.lastname: Krieger
authors.forename: Peter
authors.initials: P
authors.lastname: Valent
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging; D000465:Algorithms; D002869:Chromosome Aberrations; D003582:Cytogenetics; D018450:Disease Progression; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000235:genetics*; D009389:Neovascularization, Pathologic; D016615:Telomere / Q000648:ultrastructure; D016896:Treatment Outcome