title: Some pathophysiological regularities of formation of digestive diseases in population newly coming to the North.
abstract: OBJECTIVE
  The purpose of the work was to reveal some pathophysiological regularities of digestive diseases (DD) development, depending on a period of living in the North.
  
  
  METHODS
  A total of 1,014 workers of industrial enterprises in Mirny-city (Yakutia) have been screened according to the WHO\ CINDI program. DD have been revealed in 321 patients. Dynamics of the clinical manifestations of DD has been analyzed depending on a period of living in the North with time intervals 0-5 years, 5-9 years, 10-29 years, 30 years and more.
  
  
  METHODS
  There have been defined the content of cortisol, insulin, total cholesterol, triglycerides, alpha-cholesterol, neutrophils' activity on lysosomecation test with their percent distribution in blood serum.
  
  
  CONCLUSIONS
  It is stated that at digestive diseases, the hormonal-metabolic indices depend on a period of living in the North. The phase dynamics of changes of lipid, cortisol, insulin of cationic protein in blood neutrophils has been revealed. The data presented give more deep information about formation mechanisms of DD pathology.
authors.affiliation: Scientific Center of Clinical and Experimental Medicine SB RAMS, Novosibirsk, Russia. nicol@soramn.ru
authors.forename: Ju
authors.initials: J
authors.lastname: Nikolaev
authors.forename: A I
authors.initials: AI
authors.lastname: Paltsev
authors.forename: I Ju
authors.initials: IJ
authors.lastname: Kuznetsova
authors.forename: I M
authors.initials: IM
authors.lastname: Mitrofanov
mesh_terms: D000328:Adult; D005260:Female; D005767:Gastrointestinal Diseases / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D041981:Gastrointestinal Tract / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D007328:Insulin / Q000032:analysis; D008055:Lipids / Q000032:analysis / Q000097:blood; D008297:Male; D009504:Neutrophils / Q000276:immunology; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D013997:Time Factors
chemical_list: D007328:Insulin; D008055:Lipids; D006854:Hydrocortisone