[Expressions of endothelin-1 in benign prostatic hyperplasia and prostate cancer and their significance].
OBJECTIVE
To investigate the different expressions of endothelin-1 ET-1) in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) tissues and their clinical significance.


METHODS
A total of 36 BPH and 44 PCa specimens were examined for the expression of ET-1 by immunohistochemical technique (Elivision plus method). The staining intensity for ET-1 was assessed by light microscopy on a scale from "-" to "+ + +".


RESULTS
Positive immunoreactivity was found in BPH and PCa, with a positive rate of 100%. Positive staining was located mostly in the cytoplasm of glandular epithelia and smooth muscle cells of both BPH and PCa and was noted in all stroma vascular endothelial cells. These were no significant differences in the intensity of positive staining for ET-1 between the groups of BPH and PCa (P > 0.05), bone metastasis (BM) and non-BM (P > 0.05), and highly and moderately differentiated PCa (P > 0.05), but the staining intensity for ET-1 was significantly higher in the poorly than in the highly and moderately differentiated PCa (P < 0.01).


CONCLUSIONS
ET-1 has a high expression and the localization is the same in both BPH and PCa. It is involved in the development and progression of BPH and PCa.
Zhou
Wen-quan
WQ
Department of Urology, Clinical Medical College of the Second Military Medical University/Nanjing General Hospital of Nanjing Command, Nanjing, Jiangsu 210002, China.
Sun
Ying-hao
YH
Yin
Hong-lin
HL
Zhang
Zheng-yu
ZY
Ge
Jing-ping
JP
Cheng
Wen
W
Ma
Hong-qing
HQ
Wei
Wu
W
Zhou
Shui-gen
SG
Ma
Heng-hui
HH
Gao
Jian-ping
JP
D000368:Aged; D000369:Aged, 80 and over; D019332:Endothelin-1 / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
D019332:Endothelin-1