title: Counterpoint: the argument for combination chemotherapy in the treatment of metastatic breast cancer.
abstract: The question of combination versus single-agent chemotherapy in the setting of metastatic breast cancer (MBC) is an often-debated issue. Many single agents have activity in this setting and the potential for significant synergism between chemotherapy agents has led to many combination chemotherapy trials. This article defends the position that combination chemotherapy is the optimal approach for patients with MBC.
authors.affiliation: Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Cianfrocca
authors.forename: William J
authors.initials: WJ
authors.lastname: Gradishar
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality* / Q000473:pathology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis