Preservation of motor programs in paraplegics as demonstrated by attempted and imagined foot movements.
Execution and imagination of movement activate distinct neural circuits, partially overlapping in premotor and parietal areas, basal ganglia and cerebellum. Can long-term deafferented/deefferented patients still differentiate attempted from imagined movements? The attempted execution and motor imagery network of foot movements have been investigated in nine chronic complete spinal cord-injured (SCI) patients using fMRI. Thorough behavioral assessment showed that these patients were able to differentiate between attempted execution and motor imagery. Supporting the outcome of the behavioral assessment, fMRI disclosed specific patterns of activation for movement attempt and for motor imagery. Compared with motor execution data of healthy controls, movement attempt in SCI patients revealed reduced primary motor cortex activation at the group level, although activation was found in all single subjects with a high variability. Further comparisons with healthy subjects revealed that during attempt and motor imagery, SCI patients show enhanced activation and recruitment of additional regions in the parietal lobe and cerebellum that are important in sensorimotor integration. These findings reflect central plastic changes due to altered input and output and suggest that SCI patients may require additional cognitive resources to perform these tasks that may be one and the same phenomenon, or two versions of the same phenomenon, with quantitative differences between the two. Nevertheless, the retained integrity of movement attempt and motor imagery networks in SCI patients demonstrates that chronic paraplegics can still dispose of the full motor programs for foot movements and that therefore, attempted and imagined movements should be integrated in rehabilitative strategies.
Hotz-Boendermaker
Sabina
S
Spinal Cord Injury Centre, Balgrist University Hospital Zurich, Switzerland.
Funk
Marion
M
Summers
Paul
P
Brugger
Peter
P
Hepp-Reymond
Marie-Claude
MC
Curt
Armin
A
Kollias
Spyros S
SS
D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D019054:Evoked Potentials, Motor; D005260:Female; D005528:Foot / Q000503:physiopathology*; D006801:Humans; D007092:Imagination; D033182:Intention; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology*; D010264:Paraplegia / Q000503:physiopathology*; D013119:Spinal Cord Injuries / Q000503:physiopathology