title: Development of spontaneous seizures after experimental status epilepticus: implications for understanding epileptogenesis.
abstract: This report examines several concepts concerning the latent period to the first convulsive seizure, subsequent increases in seizure frequency, and possible mechanisms of epileptogenesis after kainate-induced status epilepticus. Previous data concerning the latent period and seizure progression from intermittent and continuous behavioral monitoring are compared, and hypothetical mechanisms of acquired epilepsy are discussed. Data involving electrographic recordings with tethered animals or with radiotelemetry are assessed in terms of their potential for addressing different hypotheses concerning the latent period and progressive changes in seizure frequency. Experimental analyses of the time course of occurrence of spontaneous seizures are interpreted in terms of possible cellular mechanisms underlying epileptogenesis.
authors.affiliation: Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Williams
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Hellier
authors.forename: Andrew M
authors.initials: AM
authors.lastname: White
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Staley
authors.forename: F Edward
authors.initials: FE
authors.lastname: Dudek
mesh_terms: D000818:Animals; D015415:Biomarkers; D001930:Brain Injuries / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000706:statistics & numerical data*; D006801:Humans; D007608:Kainic Acid; D008959:Models, Neurological; D008991:Monitoring, Physiologic; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology*; D013226:Status Epilepticus / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology*; D013686:Telemetry; D013997:Time Factors; D014743:Videotape Recording
chemical_list: D015415:Biomarkers; D007608:Kainic Acid