title: Determining the source of fetal adiponectin.
abstract: OBJECTIVE
  To determine whether maternal, placental or fetal compartment contributes to the high levels of cord blood adiponectin.
  
  
  METHODS
  Serum adiponectin levels were compared from 62 newborns and their mothers as well as 32 newborns at delivery and 4 days postpartum. In addition, human placental tissues were tested for the presence of adiponectin mRNA by reverse transcriptase polymerase chain reaction.
  
  
  RESULTS
  Cord blood serum adiponectin levels were significantly higher and did not correlate with maternal adiponectin levels (32.5 +/- 7.5 vs. 11.0 +/- 3.6 microg/mL, p < 0.001). Cord blood and day 4 serum adiponectin did not differ significantly (32.6 +/- 7.6 vs. 29.5 +/- 8.4 microg/mL, p < 0.3). In addition, adiponectin mRNA was not expressed in the placenta.
  
  
  CONCLUSIONS
  These findings preclude the possibility of a placental or maternal origin of cord adiponectin. Thus, the high cord adiponectin levels may be attributed to fetal tissues.
authors.affiliation: Department of Obstetrics and Gynecology and Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Shali
authors.initials: S
authors.lastname: Mazaki-Tovi
authors.forename: Hannah
authors.initials: H
authors.lastname: Kanety
authors.forename: Clara
authors.initials: C
authors.lastname: Pariente
authors.forename: Rina
authors.initials: R
authors.lastname: Hemi
authors.forename: Yael
authors.initials: Y
authors.lastname: Efraty
authors.forename: Eyal
authors.initials: E
authors.lastname: Schiff
authors.forename: Ann
authors.initials: A
authors.lastname: Shoham
authors.forename: Eyal
authors.initials: E
authors.lastname: Sivan
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics / Q000378:metabolism; D002585:Cesarean Section; D015331:Cohort Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D047109:Fetal Development / Q000502:physiology; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D010920:Placenta / Q000737:chemistry; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis; D047929:Term Birth
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D012333:RNA, Messenger