title: Permeability profile estimation of flavonoids and other phenolic compounds by biopartitioning micellar capillary chromatography.
abstract: This paper points out the usefulness of biopartitioning micellar chromatography (BMC) using capillary columns as a high-throughput primary screening tool providing key information about the oral absorption, skin permeability, and brain-blood distribution coefficients of 15 polyphenols (6 flavones, 2 flavonols, a flavanone, 2 flavan-3-ols, 3 phenolic acids, and a phloroglucinol) in a simple and economical way. For the compounds studied, except vicenin-2, rutin, chlorogenic acid, p-hydroxycinnamic acid, and 4-hydroxybenzoic acid, maximal oral absorption (>90%) can be expected, if there are not solubility problems or metabolic processes. On the other hand, the most retained compounds in BMC, that is, 5-hydroxyflavone, flavone, and flavanone, show the highest brain-blood distribution coefficients and skin permeability coefficients.
authors.affiliation: Departamento de Ciências Farmacêuticas, CCS, Universidade Estadual de Londrina, Rod. Celso Garcia Cid, PR 445 km 380, CEP 86051-990, Londrina, PR, Brazil. maria.j.medina@uv.es
authors.forename: Andréa
authors.initials: A
authors.lastname: Diniz
authors.forename: Laura
authors.initials: L
authors.lastname: Escuder-Gilabert
authors.forename: Norberto P
authors.initials: NP
authors.lastname: Lopes
authors.forename: Leonardo
authors.initials: L
authors.lastname: Gobbo-Neto
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Villanueva-Camañas
authors.forename: Salvador
authors.initials: S
authors.lastname: Sagrado
authors.forename: María José
authors.initials: MJ
authors.lastname: Medina-Hernández
mesh_terms: D002845:Chromatography / Q000379:methods*; D005419:Flavonoids / Q000737:chemistry* / Q000493:pharmacokinetics; D008954:Models, Biological; D010539:Permeability; D010636:Phenols / Q000737:chemistry* / Q000493:pharmacokinetics; D059808:Polyphenols
chemical_list: D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols