Description of three new HLA-A*02 subtypes in Caucasians: A*0281, A*0289 and A*9224.
Three new HLA-A*02 alleles were completely characterized by sequencing-based typing (SBT). A*0281 and A*9224 showed eight clustered amino acid differences into the Bw4/Bw6 epitope at positions 74-83, regarding A*02010101. Both disclosed the same Bw4 motif described for A*25 and A*32 alleles. A*9224 has an additional mismatch at residue 265 (G>V) in the alpha3 domain, which has not been reported for any other human leukocyte antigen (HLA) class I molecule. HLA-A*0289 differed from A*02010101 in the conserved amino acid residue 192 (H>Q).
Balas
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Departamento de Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spain. abalas.trans@salud.madrid.org
Alonso-Nieto
M
M
Sánchez-Gordo
F
F
García-Sánchez
F
F
Vicario
J L
JL
D000595:Amino Acid Sequence; D001483:Base Sequence; D015234:HLA-A Antigens / Q000235:genetics*; D015789:HLA-A2 Antigen; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D044465:White People / Q000235:genetics*
D015234:HLA-A Antigens; C524866:HLA-A*02 antigen; C528707:HLA-A*02:124 antigen; C528705:HLA-A*02:81 antigen; C528706:HLA-A*02:89 antigen; D015789:HLA-A2 Antigen