A stereoselective intramolecular halo-etherification of chiral enamides in the synthesis of halogenated cyclic ethers.
A stereoselective halo-etherification of chiral enamides is described here. This work provides an approach to halogen containing cyclic ethers and reveals further mechanistic insights to the chemistry of chiral enamides.
Ko
Changhong
C
Division of Pharmaceutical Sciencies and Department of Chemistry, Rennebohm Hall 777 Highland Avenue, University of Wisconsin, Madison, Wisconsin 53705-2222, USA.
Hsung
Richard P
RP
Al-Rashid
Ziyad F
ZF
Feltenberger
John B
JB
Lu
Ting
T
Yang
Jin-Haek
JH
Wei
Yonggang
Y
Zificsak
Craig A
CA
D004988:Ethers, Cyclic / Q000138:chemical synthesis*; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure
D004988:Ethers, Cyclic; D006846:Hydrocarbons, Halogenated