Furan based cyclic oligopeptides selectively target G-quadruplex.
We report the binding properties of 18- and 24-membered cyclic oligopeptides developed from a novel furan amino acid, 5-(aminomethyl)-2-furancarboxylic acid, to G-quadruplex. Comparative analysis of the binding data of these ligands with G-quadruplex and double-strand DNA shows that 24-membered cyclic peptides are highly selective for telomeric G-quadruplex structures and thus can be used as a scaffold to target quadruplex structures at the genomic level.
Chakraborty
Tushar Kanti
TK
Indian Institute of Chemical Technology, Hyderabad 500 007, India. chakraborty@iict.res.in
Arora
Amit
A
Roy
Saumya
S
Kumar
Niti
N
Maiti
Souvik
S
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry*; D054856:G-Quadruplexes; D008024:Ligands; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000737:chemistry
C525455:5-(aminomethyl)-2-furancarboxylic acid; D000596:Amino Acids; D005663:Furans; D008024:Ligands; D009842:Oligopeptides; D010456:Peptides, Cyclic; D004247:DNA; D019098:Telomerase