Dermal peptide delivery using colloidal carrier systems.
The advancement in synthetic and molecular biology techniques over the past years has resulted in the application of peptides or peptide-like drugs becoming a growing field in therapeutics. Because of the unfavorable chemical properties of peptides, it poses a challenge to find an optimized way of drug administration. The transdermal route has attracted interest as a promising way to advance the delivery of these drugs. The objective of this review is to summarize the level of research of microemulsions as colloidal carrier for dermal peptide drug delivery. The presented studies resulted in enhanced drug delivery or superior penetration profiles of peptides incorporated in microemulsions in comparison to conventional vehicles. Due to their benefits like high solubilization capacity, enhanced drug delivery, noninvasive administration or easy preparation, microemulsions offer a suitable vehicle for dermal and transdermal drug delivery.
Goebel
Alexandra
A
Faculty of Biosciences/Institute for Pharmacy, Pharmaceutics and Biopharmaceutics, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany. alexandra.goebel@pharmazie.uni-halle.de
Neubert
Reinhard H H
RH
D000279:Administration, Cutaneous; D000818:Animals; D003102:Colloids; D020405:Dermis / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions; D006801:Humans; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology
D003102:Colloids; D004337:Drug Carriers; D004655:Emulsions; D010455:Peptides