Safety of cyclosporin A in HCV-infected patients: experience with cyclosporin A in patients affected by rheumatological disorders and concomitant HCV infection.
Because of the relatively high prevalence of both hepatitis C virus (HCV) infection and autoimmune disorders (ADs), it is not rare to encounter in daily clinical practice patients with ADs also carrying HCV. Corticosteroids and/or immunosuppressant drugs are needed to treat ADs, but they place HCV-infected patients at risk of worsening the infection. So, rheumatologists have often refrained from using corticosteroids or immunosuppressants in AD when HCV-RNA is also present. Cyclosporin A (CsA) is an immunosuppressive agent used to treat a wide range of ADs, but there is a large evidences in the literature, both in vitro and in vivo, suggesting that CsA also exerts an inhibitory effect on HCV replication at standard therapeutic dose. Therefore, this evidence has opened new ways to improve the therapy and the prognosis in patients with HCV-related liver diseases, including those with transplants. Recent reports, although limited in number, also suggest the safety of CsA in the treatment of patients with AD and concomitant HCV infection. In this review we also report our personal experience on the combination treatment with CsA and anti-TNF-alpha agents in rheumatoid arthritis.
Galeazzi
Mauro
M
U.O.C. di Reumatologia, Policlinico Le Scotte, Viale Bracci 53100 Siena, Italy. galeazzi@unisi.it
Bellisai
Francesca
F
Giannitti
Chiara
C
Manganelli
Stefania
S
Morozzi
Gabriella
G
Sebastiani
Gian Domenico
GD
D001327:Autoimmune Diseases / Q000188:drug therapy / Q000378:metabolism; D002908:Chronic Disease; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D064420:Drug-Related Side Effects and Adverse Reactions; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy* / Q000378:metabolism / Q000821:virology; D006801:Humans; D012216:Rheumatic Diseases / Q000150:complications* / Q000188:drug therapy* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism
D014409:Tumor Necrosis Factor-alpha; D016572:Cyclosporine