One-pot syntheses, coordination, and characterization of application-specific biodegradable ligand-polymers.
Syntheses and chelation of tailored biodegradable polymers to rhenium for medicinal applications are described. A group of bifunctional ligand-initiators consisting of a chelating end for metal complexation and a hydroxyl end suitable to initiate polymerization was utilized in the ring-opening polymerization of l-lactide. The resulting biodegradable ligand-polymers were equipped with a tridentate donor set to coordinate specific metal ions. All synthesized compounds were characterized by IR spectroscopy, 1D/2D NMR spectroscopy and MALDI-TOF mass spectrometry, confirming successful polymerization and coordination to the [Re(CO)(3)](+) core. The pliability of designing application-specific polymers with respect to the nature of the metal ion facilitates extending the application of these biodegradable polymers to early detection of diseases (imaging) and radiotherapy of cancers.
Saatchi
Katayoun
K
Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, British Columbia V6T 1Z3, Canada.
Häfeli
Urs O
UO
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D019275:Radiopharmaceuticals; D012211:Rhenium / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D001672:Biocompatible Materials; D008024:Ligands; D009942:Organometallic Compounds; D011091:Polyesters; D011108:Polymers; D019275:Radiopharmaceuticals; D019344:Lactic Acid; C033616:poly(lactide); D012211:Rhenium