Standard versus tailored left temporal lobe resections: differences in cognitive outcome?
This study explores differences in cognitive outcome after a standard resection (SR) or tailored (TR) in 100 patients with left temporal lobe epilepsy, controlling for extent in the three lateral gyri. Comparing preoperative to 6-month postoperative performance on a battery of intelligence, language and verbal memory tests revealed the following: a differential effect of the procedure was found for digit span, a short-term memory and attention task, the SR group showing a gain and the TR group a loss postoperatively. This could be explained by a rather large improvement of the SR group with below average resection sizes in the superior temporal gyrus (STG) (<2.8 cm), which small resections are nearly absent in TR resections. Effect of larger extent on the STG in the SR group was related to a decrease in verbal intelligence and a tendency in auditory comprehension which poses a risk in 'large' standard resections. Differences in extent of resection on the other gyri did not cause differences in effects on language functioning or verbal memory.


CONCLUSIONS
In standard anterior temporal lobe resections only (without intraoperative language mapping) up to a limit of 4.5 cm, large resections on the STG pose a risk for declining on verbal IQ and auditory comprehension. In general, tailored resections (with language mapping) result in decline on a task measuring short-term memory and attention.
Alpherts
W C J
WC
Department of Psychology, Epilepsy Centre of the Netherlands Foundation (SEIN), Heemstede, The Netherlands. walpherts@sein.nl
Vermeulen
J
J
van Rijen
P C
PC
da Silva
F H Lopes
FH
van Veelen
C W M
CW
D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D038481:Anterior Temporal Lobectomy / Q000009:adverse effects* / Q000379:methods; D001288:Attention; D002648:Child; D003072:Cognition Disorders / Q000209:etiology*; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008875:Middle Aged; D009473:Neuronal Plasticity; D009483:Neuropsychological Tests; D020127:Recovery of Function; D012189:Retrospective Studies; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome