title: Prognostic factors for malignant pericardial effusion treated by pericardial drainage in solid-malignancy patients.
abstract: OBJECTIVE
  Malignant pericardial effusion is a frequent complication of advanced incurable malignancies and requires treatment. The purpose of this study was to identify prognostic factors for cytology-positive malignant pericardial effusion in patients treated by pericardial drainage.
  
  
  METHODS
  We retrospectively analyzed a series of consecutive patients diagnosed with cytologically positive malignant pericardial effusion who were treated by pericardial drainage at the National Cancer Center Hospital, Tokyo.
  
  
  RESULTS
  A total of 88 patients with pericardial effusion were treated by pericardial drainage, 60 patients were diagnosed with cytological positive malignant pericardial effusion including 32 with non-small cell lung cancer, 13 with breast cancer, 8 with gastrointestinal cancer, and 7 with miscellaneous cancers. Subxiphoid pericardiostomy was performed in 50 of the patients and percutaneous tube pericardiostomy in the other 10 patients. Malignant pericardial effusion recurred in 14 patients, and pericardial drainage was performed again in 9 of them. The median overall survival time was 6.1 months, and the 1-year survival rate was 28%. A multivariate analysis revealed the following significant negative prognostic factors: performance status, development of malignant pericardial effusion during chemotherapy, mediastinal lymph node enlargement, and cytologic type. (P = 0.03, 0.02, 0.01, 0.001, respectively).
  
  
  CONCLUSIONS
  Patients with poor prognostic factors may be better to consider as indication of palliative therapy, even if oncologic emergency had been resolved rapidly by drainage.
authors.affiliation: Division of Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan. kyonemor@ncc.go.jp
authors.forename: Kan
authors.initials: K
authors.lastname: Yonemori
authors.forename: Hideo
authors.initials: H
authors.lastname: Kunitoh
authors.forename: Koji
authors.initials: K
authors.lastname: Tsuta
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Tamura
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Arai
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shimada
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sasajima
authors.forename: Hisao
authors.initials: H
authors.lastname: Asamura
authors.forename: Tomohide
authors.initials: T
authors.lastname: Tamura
mesh_terms: D000328:Adult; D000368:Aged; D004322:Drainage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D010490:Pericardial Effusion / Q000209:etiology / Q000473:pathology* / Q000601:surgery*; D010491:Pericardial Window Techniques; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis