Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae).
Antimalarial activity of anthothecol, a limonoid of Khaya anthotheca (Meliaceae) against Plasmodium falciparum was tested using a [(3)H]-hypoxanthine and 48h culture assay in vitro. Anthotechol showed potent antimalarial activity against malaria parasites with IC(50) values of 1.4 and 0.17microM using two different assays. Also, gedunin had antimalarial activity with IC(50) values of 3.1 and 0.14microM. However, the citrus limonoids, limonin and obacunone did not show any antimalarial activity. The antimalarial activities were compared with the three currently used antimalarial medicines quinine, chloroquinine and artemisinin.
Lee
Sung-Eun
SE
Nanotoxtech. Inc., 301 Myung Jin Building, 234-27 Nonhyeon dong, Gangnam-gu, Seoul 153-010, Republic of Korea.
Kim
Mi-Ran
MR
Kim
Jeong-Han
JH
Takeoka
Gary R
GR
Kim
Tae-Wan
TW
Park
Byeoung-Soo
BS
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D006801:Humans; D019271:Hypoxanthine; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D021241:Spectrometry, Mass, Electrospray Ionization; D014316:Tritium
D000962:Antimalarials; D036701:Limonins; D010936:Plant Extracts; C530481:anthothecol; D014316:Tritium; D019271:Hypoxanthine