[Study on the influence of biological characteristics to HIV/HCV co-infection among HIV infected illegal blood donors in China].
OBJECTIVE
To study the influence of biological characteristics on HCV/HIV co-infection, including HIV-1 sequence distance, HIV-1 viral load and CD4+ count.


METHODS
HIV-1 sequence distance was calculated by Clustal W and Phylip software while HIV-1 viral load being tested by NASBA and CD4+ count was tested using Epics XL of Coulter. Significance was determined by t-test using SPSS 12.0.


RESULTS
The mean HIV-1 genetic distances were 7.95% and 15.73% (P < 0.001) between those with HCV co-infection and those without. Their mean HIV-1 viral loads were 4.61 and 4.45 (P = 0.522) and their mean CD4I T counts were 308 and 251 (P = 0.161), respectively.


CONCLUSIONS
Data showed that in the study group, the HIV/HCV co-infection had an influence on the HIV sequence distance, but did not have major impact on HIV-1 viral load and their mean CD4+ T count.
Pan
Pin-liang
PL
National AIDS Reference Laboratory, National Center for AIDS STD Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Liu
Zhen
Z
Zhang
Yong-hong
YH
Long
Xiao-shan
XS
Wu
Hao
H
Jiang
Yan
Y
D000328:Adult; D001782:Blood Donors / Q000706:statistics & numerical data*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002681:China / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000276:immunology; D006526:Hepatitis C / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D006801:Humans; D008297:Male; D010802:Phylogeny