title: Excessive dietary vitamin D supplementation as a risk factor for sudden death syndrome in fast growing commercial broilers.
abstract: Broiler diets are frequently fortified with vitamin D (D3) above the recommended levels in an attempt to prevent commonly occurring leg problems. Since the basal levels of dietary D3 are rarely known, there is a risk of over-supplementation. Over-supplementation of D3 has been shown to have detrimental effects on the heart. Sudden death syndrome (SDS) is a condition commonly observed in broiler flocks and is associated with acute heart failure. The present study examines the effects of excessive levels of vitamin D3 on cardiac health in fast growing broiler chickens. Commercial male broilers (Gallus gallus) were exposed to either a commercial diet or a commercial diet supplemented with D3. Throughout the trial all birds were monitored several times daily for overt signs of heart disease, and periodically electrocardiographic measurements were obtained. Morbidity and mortality data were collected daily. On day 32 a simulated stress challenge consisting of a single injection of epinephrine (100 microg/kg BW) was administered under continuous ECG monitoring. Broilers fed the high D3 diet were 2.5 fold more likely to succumb to acute heart failure and die of SDS (p<0.05). Electrocardiographic examination showed a higher rate of cardiac arrhythmia in birds fed the high D3 diet (22.6%), in comparison to those fed the control diet (11.8%). The stress challenge test revealed that broilers exposed to high dietary D3 were more susceptible to ventricular arrhythmia. Our findings indicate that over-supplementation of vitamin D increases the risk of SDS in broilers, and that the most likely mechanism is associated with increased susceptibility of the ventricular myocardium to arrhythmia.
authors.affiliation: Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A8.
authors.forename: S
authors.initials: S
authors.lastname: Nain
authors.forename: B
authors.initials: B
authors.lastname: Laarveld
authors.forename: C
authors.initials: C
authors.lastname: Wojnarowicz
authors.forename: A A
authors.initials: AA
authors.lastname: Olkowski
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000401:mortality; D002645:Chickens; D019587:Dietary Supplements; D004562:Electrocardiography; D005080:Exercise Test; D006339:Heart Rate; D008297:Male; D009206:Myocardium / Q000473:pathology; D011201:Poultry Diseases / Q000401:mortality*; D012307:Risk Factors; D013997:Time Factors; D014807:Vitamin D / Q000009:adverse effects*
chemical_list: D014807:Vitamin D