Multicenter trials need to use the same assay for hepatitis C virus viral load determination.
This study, involving 20 laboratories and using currently available assays for hepatitis C virus RNA quantification, demonstrated that differences in viral load values are due not to interlaboratory variations but rather to the nature of the assay itself. This underlines the importance of using the same assay in multicenter studies or when monitoring antiviral therapy.
Laperche
Syria
S
Centre National de Référence pour les Hépatites B et C en Transfusion, Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, 6 rue Alexandre-Cabanel, 75015, Paris, France.
Bouchardeau
Françoise
F
Thibault
Vincent
V
Pozzetto
Bruno
B
Vallet
Sophie
S
Rosenberg
Arielle R
AR
Roque-Afonso
Anne-Marie
AM
Gassin
Michèle
M
Stoll-Keller
Françoise
F
Trimoulet
Pascale
P
Gault
Elyanne
E
Chanzy
Bruno
B
Mercier
Bernard
B
Branger
Michel
M
Pawlotsky
Jean-Michel
JM
Henquell
Cécile
C
Lunel
Françoise
F
Gaudy-Graffin
Catherine
C
Alain
Sophie
S
Chaix
Marie-Laure
ML
Duverlie
Gilles
G
Izopet
Jacques
J
Lefrère
Jean-Jacques
JJ
D016174:Hepacivirus / Q000302:isolation & purification*; D006801:Humans; D015337:Multicenter Studies as Topic / Q000379:methods*; D012367:RNA, Viral / Q000032:analysis*; D019562:Viral Load
D012367:RNA, Viral