Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study.
The synthesis, characterization and liposome insertion of a novel magnesium(II) carboranyl-porphyrazine, i.e. [2,3,7,8,12,13,17,18-octakis-(1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20-porphyrazine]magnesium(II) complex, MgHECSPz, are described. MgHECSPz was designed to improve the potentiality in multiple approach anticancer therapy. Liposomal formulations with different surface charge were prepared as delivering agents. The obtained loaded vectors were characterized by DLS, SAXS, SANS and zeta potential measurements in order to define the overall properties and structural details of loaded liposomes.
Salvati
Anna
A
University of Firenze, Department of Chemistry, Via della Lastruccia 3, 50019, Sesto Fiorentino (FI), Italy.
Ristori
Sandra
S
Pietrangeli
Daniela
D
Oberdisse
Julian
J
Calamai
Luca
L
Martini
Giacomo
G
Ricciardi
Giampaolo
G
D004337:Drug Carriers / Q000737:chemistry*; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D008564:Membrane Potentials; D008665:Metalloporphyrins / Q000138:chemical synthesis / Q000737:chemistry*; D033363:Neutron Diffraction; D010714:Phosphatidylethanolamines / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction
C525973:(2,3,7,8,12,13,17,18-octakis-(1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20-porphyrazine)magnesium(II); C410262:1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine; D004337:Drug Carriers; D005229:Fatty Acids, Monounsaturated; D008081:Liposomes; D008665:Metalloporphyrins; D010714:Phosphatidylethanolamines; D000644:Quaternary Ammonium Compounds; C070046:1,2-dioleoyloxy-3-(trimethylammonium)propane