Effect of an excessive intake of quercetin on the vitamin E level and antioxidative enzyme activities of mouse liver under paraquat-induced oxidative stress.
The liver alpha-tocopherol level of the paraquat fed mice group was lower than that of the control diet-fed group. An excessive intake of quercetin lowered the liver alpha-tocopherol level of the control diet-fed mice group, but did not affect it in the paraquat-fed mice group. The same quercetin intake significantly increased the superoxide dismutase and glutathione peroxidase activities in the liver of both groups, indicating that excessive quercetin intake can either promote or attenuate oxidative stress in the liver.
Bando
Noriko
N
Department of Food Science, Graduate School of Nutrition and Bioscience, The University of Tokushima, Japan.
Wakamatsu
Saori
S
Terao
Junji
J
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D005260:Female; D005979:Glutathione Peroxidase / Q000032:analysis / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress / Q000187:drug effects*; D010269:Paraquat / Q000008:administration & dosage / Q000633:toxicity*; D011794:Quercetin / Q000008:administration & dosage*; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism; D013997:Time Factors; D014810:Vitamin E / Q000032:analysis / Q000378:metabolism*; D024502:alpha-Tocopherol / Q000032:analysis / Q000378:metabolism
D000975:Antioxidants; D014810:Vitamin E; D011794:Quercetin; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D024502:alpha-Tocopherol; D010269:Paraquat