title: Alkenylzirconocene-mediated preparation of alkenylphosphines.
abstract: Alkenylphosphines with various substituents were prepared by the reaction of an alkenylzirconocene with a chlorophosphine. Reactions of (alpha-unsubstituted alkenyl)zirconocenes with Ph2PCl or PhPCl2 gave the corresponding alkenylphosphines in good yields. On the other hand, direct reactions of (alpha-unsubstituted alkenyl)zirconocenes with iPr2PCl did not proceed. Analogously, (alpha-substituted alkenyl)zirconocenes did not react with chlorophosphines directly. However, these reactions proceeded in the presence of CuCl affording the corresponding alkenylphosphines as CuCl complexes. Treatment of the copper complexes with Na2(dtc) (dtc = N,N-diethyldithiocarbamate) or Na4(edta) liberated free alkenylphosphines from the copper centers. The overall protocol could be applicable to preparation of a variety of alkenylphosphines from alkynes via alkenylzirconocene species.
authors.affiliation: Catalysis Research Center and Graduate School of Pharmaceutical Sciences, Hokkaido University, and SORST, Japan Science and Technology Agency (JST), Sapporo, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Miyaji
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Xi
authors.forename: Masamichi
authors.initials: M
authors.lastname: Ogasawara
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Nakajima
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D010720:Phosphines; D015040:Zirconium