title: Inflammatory cytokines patterns in the placenta of pregnancies complicated by HELLP (hemolysis, elevated liver enzyme, and low platelet) syndrome.
abstract: OBJECTIVE
  We investigated the expression pattern and the role of inflammatory cytokines and their receptors in the placentas of pregnancy with HELLP syndrome.
  
  
  METHODS
  Placentas were collected after cesarean section, 10 from normal pregnancy and 10 from HELLP. The array was performed with GEArray Q Series Human Inflammatory Cytokines & Receptors Gene Array HS-015. The data were confirmed by quantitative real-time PCR. The Student's t test was used for statistical analysis.
  
  
  RESULTS
  Macroarray analysis identified 14 cytokines differentially expressed. PCR confirmed that only IL-10, IL-6-receptor, and TGF-beta3 were increased, whilst CCL18, CXCL5, and IL-16 were significantly decreased, in HELLP.
  
  
  CONCLUSIONS
  The regulation of cytokines involved in angiogenesis and adaptive immune responses may be critical for the placental vascular dysfunction. Our data support the hypothesis that HELLP syndrome could be a placental inflammatory response which leads to a systemic and endothelial dysfunction.
authors.affiliation: Istituto di Scienze Materne e Infantili, Università Politecnica Marche, Ancona, Italy.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Tranquilli
authors.forename: Beatrice
authors.initials: B
authors.lastname: Landi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Corradetti
authors.forename: Stefano R
authors.initials: SR
authors.lastname: Giannubilo
authors.forename: Davide
authors.initials: D
authors.lastname: Sartini
authors.forename: Valentina
authors.initials: V
authors.lastname: Pozzi
authors.forename: Monica
authors.initials: M
authors.lastname: Emanuelli
mesh_terms: D000328:Adult; D002585:Cesarean Section; D016207:Cytokines / Q000096:biosynthesis*; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D017359:HELLP Syndrome / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis; D010920:Placenta / Q000098:blood supply / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators