title: Steroid use in sepsis-induced conjugated hyperbilirubinemia: report of one case.
abstract: We report a girl with acute lymphoblastic leukemia who developed severe conjugated hyperbilirubinemia (total bilirubin 34.32 mg/dl, direct bilirubin 26.94 mg/dl) following gram-negative (Escherichia coli ) sepsis. Despite broad-spectrum antibiotics, her hyperbilirubinemia progressed. Her mental status deteriorated and steroid therapy (hydrocortisone 8 mg/kg/d) was initiated. Her condition then recovered rapidly. Based on our findings, we suggest that steroid may help to treat progressive conjugated hyperbilirubinemia due to gram-negative sepsis.
authors.affiliation: Department of Pediatrics, Taipei Medical University-Wan Fang Medical Center, Taiwan. jlwang@wanfang.gov.tw
authors.forename: Jinn-Li
authors.initials: JL
authors.lastname: Wang
authors.forename: Tsong-Yih
authors.initials: TY
authors.lastname: Ou
authors.forename: Chun-Nan
authors.initials: CN
authors.lastname: Chen
authors.forename: Ein-Yiao
authors.initials: EY
authors.lastname: Shen
mesh_terms: D016470:Bacteremia / Q000150:complications*; D002648:Child; D004927:Escherichia coli Infections / Q000150:complications*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D006932:Hyperbilirubinemia / Q000188:drug therapy / Q000209:etiology*; D010289:Parenteral Nutrition, Total
chemical_list: D006854:Hydrocortisone