Simple machine-assisted protocol for solid-phase synthesis of depsipeptides.
A straightforward machine-assisted protocol for the synthesis of linear depsipeptides is reported. The synthesis was performed on a 433A Peptide Synthesizer (Applied Biosystems) using preprogrammed and optimized modules for Boc chemistry and without any need for hardware modification. The robustness of the protocol was demonstrated with 12 examples of 26-membered depsipeptides with single and multiple (up to 6) ester backbone substitutions.
Spengler
Jan
J
Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, E-08028 Barcelona, Spain. jspengler@pcb.ub.es
Koksch
Beate
B
Albericio
Fernando
F
D001331:Automation; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation*; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D047630:Depsipeptides