Association between prostate-specific antigen and leptin, adiponectin, HbA1c or C-peptide among African-American and Caucasian men.
Prior studies report slightly lower prostate-specific antigen (PSA) levels among obese men. To understand this effect, we investigated the association between PSA and blood HbA1c, C-peptide, leptin and adiponectin levels in African-American (AA) (n=121) and Caucasian (CA) (n=121) men. Among AA men, PSA levels decreased with increasing C-peptide levels (PSA=0.99, 0.93, 0.75 and 0.53 ng ml(-1) across quartiles of C-peptide, respectively; P(trend)=0.005). Among CA men, PSA levels decreased with increasing HbA1c (PSA=0.84, 0.73, 0.77 and 0.45 ng ml(-1) across quartiles of HbA1c, respectively; P(trend)=0.005). This may suggest that metabolic disturbances related to metabolic syndrome or diabetes affect the ability to detect early-stage prostate cancer.
Fowke
J H
JH
Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37203-1738, USA. jay.fowke@vanderbilt.edu
Matthews
C M
CM
Buchowski
M S
MS
Signorello
L B
LB
Chang
S S
SS
Cookson
M S
MS
Blot
W J
WJ
D052242:Adiponectin / Q000097:blood; D000328:Adult; D001741:Black or African American; D000368:Aged; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood*; D015331:Cohort Studies; D048909:Diabetes Complications / Q000097:blood; D042241:Early Diagnosis; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000208:ethnology; D044465:White People
D052242:Adiponectin; D002096:C-Peptide; D006442:Glycated Hemoglobin; D020738:Leptin; D017430:Prostate-Specific Antigen; C499918:ADIPOQ protein, human; C517652:hemoglobin A1c protein, human