title: CSF IgH gene rearrangement analysis in isolated post-transplant lymphoproliferative disorder of the central nervous system.
abstract: Isolated post-transplant lymphoproliferative disorder (PTLD) of the central nervous system is rare and its diagnosis can be challenging. A biopsy is usually required in order to distinguish the disease from opportunistic infections. We present a case in whom immunoglobulin heavy chain gene rearrangement analysis of cerebrospinal fluid (CSF) was instrumental in establishing the diagnosis.
authors.affiliation: Department of Neurology and Neurosurgery, Yale University School of Medicine, 333 Cedar Street, TMP412, New Haven, CT 06510, USA. Joachim.baehring@yale.edu
authors.forename: Joachim M
authors.initials: JM
authors.lastname: Baehring
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Landry
authors.forename: Dennis
authors.initials: D
authors.lastname: Cooper
authors.forename: Pei
authors.initials: P
authors.lastname: Hui
authors.forename: Serguei
authors.initials: S
authors.lastname: Bannykh
mesh_terms: D000368:Aged; D018951:Antigens, CD20 / Q000378:metabolism; D002490:Central Nervous System / Q000473:pathology*; D005260:Female; D015321:Gene Rearrangement / Q000502:physiology*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000134:cerebrospinal fluid*; D016030:Kidney Transplantation / Q000009:adverse effects; D008232:Lymphoproliferative Disorders / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000276:immunology* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods
chemical_list: D018951:Antigens, CD20; D007143:Immunoglobulin Heavy Chains