title: Increased serum levels of soluble CD30 in patients with common variable immunodeficiency and its clinical implications.
abstract: Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent pyogenic infections, autoimmunity, and malignancies. Twenty-five cases with CVID (18 male and 7 female) and 25 healthy volunteers were investigate in this study. Soluble CD30 (sCD30) serum levels of the subjects were measured and compared. Serum levels of sCD30 in the patients with CVID were significantly increased in comparison with controls (36.93 +/- 32.38 vs 5.27 +/- 1.32 U/ml, P < 0.001). The group of patients with splenomegaly and reversed ratio of CD3+CD4+ T cells/CD3+CD8+ T cells had the highest serum levels of sCD30 (66.01 +/- 43.34 U/ml) in comparison with other patients (P = 0.010). High levels of sCD30 in the CVID patients with splenomegaly and the presence of lymphoma in a patient with the highest level of sCD30 may suggest a soluble form of this marker as a prognostic tool in such diseases.
authors.affiliation: Immunology, Asthma and Allergy Research Institute, Children's Medical Center, Medical Sciences/University of Tehran, no. 62, Dr. Gharib St, Keshavarz Blvd, P.O. Box 14185-863 Tehran, 14194, Iran. rezaei_nima@hbi.ir
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
authors.forename: Mostafa
authors.initials: M
authors.lastname: Haji-Molla-Hoseini
authors.forename: Asghar
authors.initials: A
authors.lastname: Aghamohammadi
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Pourfathollah
authors.forename: Mina
authors.initials: M
authors.lastname: Moghtadaie
authors.forename: Zahra
authors.initials: Z
authors.lastname: Pourpak
mesh_terms: D000293:Adolescent; D000328:Adult; D016175:B-Lymphocyte Subsets; D002648:Child; D002675:Child, Preschool; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D017730:Ki-1 Antigen / Q000097:blood*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets
chemical_list: D007136:Immunoglobulins; D017730:Ki-1 Antigen