title: Phospho-regulation of Beta-catenin adhesion and signaling functions.
abstract: Beta-catenin plays a critical structural role in cadherin-based adhesions and is also an essential co-activator of Wnt-mediated gene expression. The degree to which beta-catenin participates in these two functions is dictated by the availability of beta-catenin binding partners, and an emerging theme is that these binding interactions are regulated by phosphorylation. Inputs from various cell-signaling events can therefore impact beta-catenin function, which may be necessary for the finely tuned adhesive and signaling responses required for tissue morphogenesis.
authors.affiliation: The Integrated Graduate Program in the Life Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. c-gottardi@northwestern.edu
authors.forename: Rebecca Leadem
authors.initials: RL
authors.lastname: Daugherty
authors.forename: Cara J
authors.initials: CJ
authors.lastname: Gottardi
mesh_terms: D000818:Animals; D015820:Cadherins / Q000737:chemistry / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D010766:Phosphorylation; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs / Q000502:physiology; D015398:Signal Transduction; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism; D051153:Wnt Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051176:beta Catenin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D015820:Cadherins; D004268:DNA-Binding Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D051176:beta Catenin