Collecting duct epithelium and injury: not all cells are created equal.
Studies by Butt et al. in the developing fetus provide new and timely insights into the regulation of repair and fibrosis in the injured kidney. Using a clinically relevant model, they have examined the response of the medullary collecting duct to ureteral obstruction, with some unexpected findings.
Hewitson
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TD
Department of Nephrology, Royal Melbourne Hospital, Melbourne, Victoria, Australia. tim.hewitson@mh.org.au
D000818:Animals; D051399:Aquaporin 2 / Q000378:metabolism; D024402:Carbonic Anhydrase II / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005355:Fibrosis; D007679:Kidney Medulla / Q000196:embryology / Q000378:metabolism / Q000473:pathology*; D007685:Kidney Tubules, Collecting / Q000196:embryology / Q000378:metabolism / Q000473:pathology*; D008253:Macaca mulatta; D008648:Mesoderm / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy; D014517:Ureteral Obstruction / Q000378:metabolism / Q000473:pathology
D051399:Aquaporin 2; D024402:Carbonic Anhydrase II