[Role of heat shock protein in gastric mucosal protection].
Mild stress protects gastric mucosa against ensuing severe stress, a phenomenon named as adaptive cytoprotection. A number of studies have shown that adaptive cytoprotection was not affected by inhibition of endogenous PG synthesis, but was blocked by inhibition of protein synthesis. It has been reported that mild stress induces HSP in a variety of tissues, which prevents tissue injury against more severe stress. We hypothesized that HSP may play a major role in adaptive cytoprotection in gastric mucosa against a various stresses such as H. pylori and NSAIDs. In this paper, we show that GGA, a well known HSP inducer, protects gastric mucosa against various stresses, such as heat, H. pylori, and NSAIDs in bullfrog, mice and humans.
Yanaka
Akinori
A
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D004224:Diterpenes / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D051379:Mice
D000897:Anti-Ulcer Agents; D004224:Diterpenes; D006360:Heat-Shock Proteins; C031049:geranylgeranylacetone