title: HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population.
abstract: The heat shock 60-kDa protein 1 (HSP60) is involved in immune and inflammatory reactions, which are hallmarks of rheumatoid arthritis (RA). HSP60 is encoded by the HSPD1 gene located on 2q33, one of the suggested RA susceptibility loci in the French Caucasian population. Our aim was to test whether HSPD1 is a major susceptibility gene by studing families from the French Caucasian population. Three single nucleotide polymorphisms (SNPs) were studied in 100 RA trio families, and 100 other families were used for replication. Genetic analyses were performed by comparing allelic frequencies, by applying the transmission disequilibrium test, and by assessing the genotype relative risk. We observed a significant RA association for the C/C genotype of rs2340690 in the first sample. However, this association was not confirmed when the second sample was added. The two other SNPs and the haplotype analysis did not give any significant results. We conclude that HSPD1 is not a major RA susceptibility gene in the French Caucasian population.
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France. Laurent@polyarthrite.net.|Hôpital Sud Francilien, 59 bd Henri Dunant, 91100, Corbeil-Essonnes, France. Laurent@polyarthrite.net.
authors.forename: Laurent
authors.initials: L
authors.lastname: Jacq
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.|Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
authors.forename: Vitor Hugo
authors.initials: VH
authors.lastname: Teixeira
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Garnier
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Michou
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.|Hôpital Bichat, AP-HP, 46 rue Henri Huchart, 75018, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Dieudé
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Rocha
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Pierlot
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.|Hôpital Sud Francilien, 59 bd Henri Dunant, 91100, Corbeil-Essonnes, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lemaire
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.|Hôpital Sud Francilien, 59 bd Henri Dunant, 91100, Corbeil-Essonnes, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Quillet
authors.affiliation: Hôpital Sud Francilien, 59 bd Henri Dunant, 91100, Corbeil-Essonnes, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Hilliquin
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
authors.forename: Hamdi
authors.initials: H
authors.lastname: Mbarek
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Petit-Teixeira
authors.affiliation: GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057, Evry-Genopole cedex, France.|Hôpital Sud Francilien, 59 bd Henri Dunant, 91100, Corbeil-Essonnes, France.|Hôpital Lariboisière, AP-HP, 2 rue Ambroise Paré, 75010, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Cornélis
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D018834:Chaperonin 60; D018833:Chaperonins / Q000235:genetics*; D005192:Family Health; D005260:Female; D005602:France / Q000208:ethnology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D024101:Mitochondrial Proteins; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics*
chemical_list: D018834:Chaperonin 60; C060293:HSPD1 protein, human; D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D018833:Chaperonins