title: Development and organization of the human brain tissue compartments across the lifespan using diffusion tensor imaging.
abstract: We used a diffusion tensor imaging-based whole-brain tissue segmentation to characterize age-related changes in (a) whole-brain grey matter, white matter, and cerebrospinal fluid relative to intracranial volume and (b) the corresponding brain tissue microstructure using measures of diffusion tensor anisotropy and mean diffusivity. The sample, a healthy cohort of 119 right-handed males and females aged 7-68 years. Our results demonstrate that white matter and grey matter volumes and their corresponding diffusion tensor anisotropy and mean diffusivity follow nonlinear trajectories with advancing age. In contrast, cerebrospinal fluid volume increases linearly with age.
authors.affiliation: Department of Diagnostic and Interventional Imaging, University of Texas-Houston Health Science Center, Houston, Texas, USA. Khader.M.Hasan@uth.tmc.edu
authors.forename: Khader M
authors.initials: KM
authors.lastname: Hasan
authors.forename: Ambika
authors.initials: A
authors.lastname: Sankar
authors.forename: Christopher
authors.initials: C
authors.lastname: Halphen
authors.forename: Larry A
authors.initials: LA
authors.lastname: Kramer
authors.forename: Michael E
authors.initials: ME
authors.lastname: Brandt
authors.forename: Jenifer
authors.initials: J
authors.lastname: Juranek
authors.forename: Paul T
authors.initials: PT
authors.lastname: Cirino
authors.forename: Jack M
authors.initials: JM
authors.lastname: Fletcher
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Papanicolaou
authors.forename: Linda
authors.initials: L
authors.lastname: Ewing-Cobbs
mesh_terms: D000293:Adolescent; D041923:Adolescent Development / Q000502:physiology*; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D016880:Anisotropy; D001284:Atrophy / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development*; D001931:Brain Mapping / Q000379:methods*; D002552:Cerebral Ventricles / Q000033:anatomy & histology / Q000254:growth & development; D002648:Child; D002657:Child Development / Q000502:physiology*; D015331:Cohort Studies; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000502:physiology / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology / Q000502:physiology; D019581:Neuropil / Q000166:cytology / Q000502:physiology; D017711:Nonlinear Dynamics; D013346:Subarachnoid Space / Q000033:anatomy & histology / Q000254:growth & development