Hedgehog signaling pathway.
The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Jacob
Leni
L
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lum
Lawrence
L
D000818:Animals; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction
D053823:Hedgehog Proteins