Poly(ADP-ribosyl)ation in mammalian ageing.
Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA damage-induced poly(ADP-ribosyl)ation and mammalian longevity. Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through which poly(ADP-ribosyl)ation might act as a factor that limits the rate of ageing.
Beneke
Sascha
S
Molecular Toxicology Group, Department of Biology, University of Konstanz, D-78457 Konstanz, Germany.
Bürkle
Alexander
A
D000375:Aging / Q000502:physiology*; D000818:Animals; D016923:Cell Death; D004260:DNA Repair; D042822:Genomic Instability; D006801:Humans; D051379:Mice; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D051381:Rats; D014158:Transcription, Genetic
D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases