Dual mechanisms of DNA damage by MoCH(3)(eta(3)-allyl)(CO)(2)(phen) complexes.
DNA damage by MoCH3(eta3-allyl)(CO)2(phen) complexes has been shown to occur by two mechanisms: by backbone cleavage via the abstraction of H1' and/or H5' from the deoxyribose moiety and by base modification, resulting in G-specific cleavage via the formation of base-labile residues methylguanine, methoxyguanine, and 8-oxo-G.
Mohler
Debra L
DL
Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA. mohlerdl@jmu.edu
Shell
Jennifer R
JR
Coonce
Janet G
JG
Mirandi
Jessica L
JL
Riera
Lucía
L
Cuesta
Luciano
L
Pérez
Julio
J
D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry
D009942:Organometallic Compounds; D008982:Molybdenum; D004247:DNA