Current challenges in autotransport and two-partner protein secretion pathways.
The two-partner and autotransport pathways are widely represented in Gram-negative bacteria, essentially among pathogens. Both mediate the translocation of large proteins across the outer membrane. Deciphering the molecular mechanisms of secretion machineries as well as folding of exoproteins in the course of translocation represents a current challenge.
Hodak
Hélène
H
INSERM U629, Institut Pasteur de Lille, IFR142, 1 Rue du Professeur Calmette, 59019 Lille Cedex, France.
Jacob-Dubuisson
Françoise
F
D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D001692:Biological Transport; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D018832:Molecular Chaperones / Q000502:physiology; D019897:Periplasm / Q000378:metabolism; D017510:Protein Folding
D001426:Bacterial Proteins; D018832:Molecular Chaperones