title: Ab initio and density functional theory evidence on the rate-limiting step in the Morita-Baylis-Hillman reaction.
abstract: The first ab initio and DFT studies on the mechanism of the MBH reaction show that the rate-limiting step involves an intramolecular proton transfer in the zwitterionic intermediate generated by the addition of enolate to electrophile. The activation barrier for the C-C bond-formation is found to be 20.2 kcal/mol lower than the proton-transfer step for the MBH reaction between methyl vinyl ketone and benzaldehyde catalyzed by DABCO.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, India.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Roy
authors.forename: Raghavan B
authors.initials: RB
authors.lastname: Sunoj