Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6.
Instrumental conditioning allows animals to learn about the consequences of their own actions, but the underpinning molecular mechanisms remain elusive. Here we show that the sphingosine-1-phosphate (S1P) receptor Gpr6 is selectively expressed in the striatopallidal neurons in the striatum. Gpr6-deficient mice showed reduced striatal cyclic AMP production in vitro and selective alterations in instrumental conditioning in vivo. Thus, Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal.
Lobo
Mary Kay
MK
Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California at Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095, USA.
Cui
Yijun
Y
Ostlund
Sean B
SB
Balleine
Bernard W
BW
Yang
X William
XW
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D005576:Colforsin / Q000494:pharmacology; D003216:Conditioning, Operant / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D005508:Food Deprivation; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D005917:Globus Pallidus / Q000166:cytology*; D049452:Green Fluorescent Proteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D011930:Reaction Time / Q000235:genetics; D049349:Receptors, Lysosphingolipid / Q000172:deficiency / Q000378:metabolism*
D049349:Receptors, Lysosphingolipid; D049452:Green Fluorescent Proteins; D005576:Colforsin; D000242:Cyclic AMP