title: [The genetics of child temperament].
abstract: BACKGROUND
  In spite of the high initial expectancy in preliminary results concerning the genetics of personality, these studies have not provided satisfactory results. The failure could be related to the lack of biological validity of personality concept and the important influence of environmental factors on personality. A possible way to solve this problem is to look at the temperament of preschool children. It is expected that variability in infants' behaviour can be better defined and with less environmental influence.
  
  
  METHODS
  Firstly, twin and adoption studies of child temperament in comparison with the studies of personality in adults are reviewed. Secondly, the molecular association studies carried out concerning child temperament are analyzed. The serotonin transporter gene (5-HTT), D4 receptor gene (DRD4) and mono amino oxidade-A gene (MAOA) have been considered candidates to explain variability in child temperament because these genes have been related with specific personality dimensions and mental diseases. Finally, the methodological problems and the future direction of research in this field are considered.
  
  
  CONCLUSIONS
  Heritability shows higher values in infant temperament than in adult personality. Different gene polymorphisms on 5-HTT, DRD4 and MAOA could explain some individual variability in children's behavior, although replication studies are needed to confirm the role of these genes. Longitudinal studies in large samples that include gene and environmental interactions are one of the best ways to improve our knowledge about the genetics of child temperament.
authors.affiliation: Laboratorio de Genética Molecular y Humana, Departamento de Genética, Universidad de Valencia. Facultad de Biología, 46010 Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ivorra-Martínez
authors.forename: J
authors.initials: J
authors.lastname: Gilabert-Juan
authors.forename: M D
authors.initials: MD
authors.lastname: Moltó-Ruiz
authors.forename: J
authors.initials: J
authors.lastname: Sanjuán
mesh_terms: D000300:Adoption; D000818:Animals; D001519:Behavior / Q000502:physiology*; D002675:Child, Preschool; D005190:Family / Q000523:psychology; D006801:Humans; D008995:Monoamine Oxidase / Q000235:genetics; D011110:Polymorphism, Genetic; D050638:Receptors, Dopamine D4 / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D013694:Temperament / Q000502:physiology; D014427:Twins / Q000235:genetics
chemical_list: C493599:DRD4 protein, human; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D050638:Receptors, Dopamine D4; D008995:Monoamine Oxidase