Transcription factors NFAT2 and Egr1 cooperatively regulate the maturation of T-lymphoma in vitro.
We have demonstrated that transcription factors Egr1 and NFAT2 cooperate in regulation of the early stages of T-lymphocyte development, whereas the related factors Egr2 and Egr3 do not cooperate with NFAT2. Egr1 and NFAT2 are shown to cooperatively control gene expression of the regulatory factor Id3 and recombinase Rag2, whose functions are critical for T-lymphocyte differentiation. Thus, the concerted action of the transcription factors Egr1 and NFAT2 can play a crucial role in regulation of the T cell differentiation in vitro due to the cooperative regulation of Id3 and Rag2 gene expression.
Koltsova
E K
EK
Moscow State Medical Stomatological University, Moscow 127473, Russia. ekoltsova@gmail.com
Wiest
D L
DL
Vavilova
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TP
D000818:Animals; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000378:metabolism; D051766:Early Growth Response Protein 1 / Q000502:physiology*; D051767:Early Growth Response Protein 2 / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D051796:Inhibitor of Differentiation Proteins / Q000378:metabolism; D053645:Interleukin-2 Receptor alpha Subunit / Q000096:biosynthesis; D016399:Lymphoma, T-Cell; D051379:Mice; D050778:NFATC Transcription Factors / Q000502:physiology*; D015221:Potassium Channels / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology*
D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; D051767:Early Growth Response Protein 2; C486109:Egr1 protein, mouse; C497327:Egr2 protein, mouse; C488358:Erg3 protein, mouse; D051796:Inhibitor of Differentiation Proteins; D053645:Interleukin-2 Receptor alpha Subunit; D050778:NFATC Transcription Factors; D015221:Potassium Channels; C499308:Rag2 protein, mouse; C067679:Idb3 protein, mouse