Chromosome kissing.
Eukariotic chromosomes occupy distinct territories in the cell nucleus. These territories intermingle little with other chromosomes. Nevertheless, several contacts between different chromosomal loci have been documented, a phenomenon called chromosome kissing. Some of these contacts may arise simply because of preferred chromosome neighborhoods and of the sharing of transcriptional machineries, while others seem to have exquisite regulatory functions. Recent approaches that allow to detect chromosome kissing events in an unbiased manner suggest that chromatin folding is such that cis contacts with neighboring elements are most frequent, but contacts with remote parts of the same chromosome or with different chromosomes are possible. These contacts are modulated by specific chromatin features of each locus, and they may play important roles in the regulation of gene expression. Chromosome kissing events may also be at the origin of chromosomal rearrangements.
Cavalli
Giacomo
G
Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier, France. Giacomo.Cavallli@igh.cnrs.fr
D002843:Chromatin / Q000378:metabolism*; D045584:Chromosome Positioning; D002877:Chromosomes, Human / Q000378:metabolism; D020868:Gene Silencing; D023281:Genomics; D006801:Humans; D014158:Transcription, Genetic / Q000502:physiology; D014178:Translocation, Genetic / Q000502:physiology
D002843:Chromatin