Resveratrol: is there any effect on healthy subject?
This preliminary study was planned to investigate the effects of resveratrol on oxidative-nitrosative stress markers and on trace element concentrations in blood and on circulatory system parameters in rats. Twenty-five Sprague-Dawley male rats, 10-12 weeks old, with mean body weight of 295 g were used in the study. Administration of resveratrol (0.5 ml/day) was performed in experimental group in 10 days. In control (n = 10) and in experimental groups (n = 15), after 1 week training period, systolic arterial blood pressures and heart rates were recorded daily. At the end of the tenth day, blood samples of control and experimental groups were drawn. Total nitrite, nitrite, nitrate, malondialdehyde, copper, zinc concentrations in plasma, superoxide dismutase, and catalase activities and copper, zinc concentrations in red cell were determined both in control and experimental groups. Alterations in oxidative and nitrosative stress markers, trace element concentrations, and circulatory system parameters in experimental group compared to controls were observed. The results of this study were discussed according to the effect of resveratrol.
Kavas
Güzin Ozelçi
GO
Faculty of Medicine, Department of Pathophysiology, Ankara University, Sihhiye, Ankara 06100, Turkey.
Aribal-Kocatürk
Pelin
P
Büyükkağnici
Demet Iren
DI
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D003300:Copper / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D009584:Nitrogen / Q000737:chemistry / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D015032:Zinc / Q000737:chemistry
D000975:Antioxidants; D017382:Reactive Oxygen Species; D013267:Stilbenes; D009569:Nitric Oxide; D008315:Malondialdehyde; D003300:Copper; D002374:Catalase; D015032:Zinc; D009584:Nitrogen; D000077185:Resveratrol; D010100:Oxygen