Amelioration of arsenic toxicity by L-Ascorbic acid in laboratory rat.
A study so as to confirm the protective effects of L-ascorbic acid against inorganic arsenic (As23) toxicity was made in male Wistar rats. Multiphase observations made on iAs concentration in target organs viz. liver and kidney, liver function, histopathological changes, ultrastructural alterations, lipid peroxidation, oxidative stress and iAs-DNA interaction strongly favoured its ameliorative effects. These effects could mainly be attributed to its antioxidative property. It offers help in regeneration of GSH and alpha-tocopherol. The chelaticn of iAs by ascorbic acid has also been hypothesized. Inhibition of DNA damage by ascorbic acid in liver and kidney appears to be the most significant part of this study On the basis of these results, we conclude that administration of L-ascorbic acid to arsenic affected population may prevent the occurrence of fatal human diseases.
Singh
Sohini
S
Department of Zoology, Toxicology Laboratory, Ch. Charan Singh University, Meerut-250 004, India.
Rana
S V S
SV
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001151:Arsenic / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity / Q000652:urine; D020261:Arsenic Poisoning / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D004249:DNA Damage / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D019803:Glutathione Disulfide / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D001151:Arsenic; D001205:Ascorbic Acid; D001663:Bilirubin; D019803:Glutathione Disulfide