New light on an old story: facile and efficient synthesis of 1,3-diaryl-5-spirohexahydropyrimidines via a six-molecule, three-component mannich-type reaction.
A facile and efficient synthesis of 1,3-diaryl-5-spirohexahydropyrimidines via a one-pot condensation of anilines, formaldehyde, and cyclohexanones is reported. In this one-pot, three-component reaction, six molecules of reactants are involved and six new covalent bonds are generated. Bicyclic products are obtained from the starting materials in one pot using readily available starting materials and catalysts.
Wei
Hai-Long
HL
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
Yan
Ze-Yi
ZY
Niu
Yan-Ning
YN
Li
Gao-Qiang
GQ
Liang
Yong-Min
YM
D018360:Crystallography, X-Ray; D003512:Cyclohexanones / Q000737:chemistry*; D005557:Formaldehyde / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D003512:Cyclohexanones; D011725:Pyridines; D011743:Pyrimidines; D005557:Formaldehyde