A practical synthesis of differentially protected 2-(hydroxymethyl)piperazines.
An efficient and scalable synthesis of three differentially protected 2-(hydroxymethyl)piperazines is presented, starting from optically active and commercially available (2S)-piperazine-2-carboxylic acid dihydrochloride. These synthetic building blocks are useful in the preparation of biologically active compounds and as chemical scaffolds for the construction of combinatorial libraries.
Gao
Hongwu
H
Pfizer Global Research and Development, 34790 Ardentech Court, Fremont, California 94555, USA.
Renslo
Adam R
AR
D008968:Molecular Conformation; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry
D010879:Piperazines