Efficient use of the iron ortho-nitrophenylporphyrin chloride to mimic biological oxidations of dimethylaminoantipyrine.
Major metabolites of dimethylaminoantipyrine have been synthesized using iron ortho-nitrophenylporphyrin chloride as biomimetic catalyst. Reactivity of iron tetrakis-ortho-nitrophenylporphyrin chloride [Fe(TNO2PP)Cl] has been compared with iron tetrakis-pentafluorophenylporphyrin chloride and iron tetrakis-2,6-dichlorophenylporphyrin chloride using various oxidants such as hydrogen peroxide, iodosobenzene, and cumene hydroperoxide in either protic or aprotic solvent. Effect of imidazole has been showed on the reactivity of Fe(TNO2PP)Cl/cumene hydroperoxide system.
Bazin
Marc J
MJ
Shi
Helen
H
Delaney
Jeannine
J
Kline
Billie
B
Zhu
Zhendong
Z
Kuhn
Cyrille
C
Berlioz
Francoise
F
Farley
Kathleen A
KA
Fate
Gwen
G
Lam
Wing
W
Walker
Gregory S
GS
Yu
Linning
L
Pollastri
Michael P
MP
D000632:Aminopyrine / Q000737:chemistry* / Q000378:metabolism; D002712:Chlorides / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D008665:Metalloporphyrins / Q000737:chemistry*; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction
D002712:Chlorides; D008665:Metalloporphyrins; D016877:Oxidants; D000632:Aminopyrine; D006861:Hydrogen Peroxide; D007501:Iron