title: Spontaneously regressed Langerhans cell histiocytosis of lymph nodes in an elderly patient.
abstract: Langerhans cell tumors are neoplastic proliferation of Langerhans cells and are classified into Langerhans cell histiocytosis (LCH) and Langerhans cell sarcoma (LCS). We report a case of LCH in an 89-year-old-woman with left axillary lymphadenopathy. A histologic examination demonstrated a proliferation of histiocytoid cells which were positive for CD1a, S-100 protein, and Lagerin (CD207). Initial diagnosis was LCS based on morphologic features, high MIB-1 index, and multi-system involvement detected by FDG-PET. However, the disease disappeared spontaneously without specific treatment in six months. The disease was considered to be spontaneously regressed LCH with multi-system involvement rather than LCS.
authors.affiliation: Department of hematology, Teshi hospital, Sapporo. tohrut@cocoa.ocn.ne.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Takahashi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Yoshimoto
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kondoh
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D011877:Radionuclide Imaging; D012075:Remission, Spontaneous