Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity.
Two new diarylheptanoids (1, 2), together with two known analogs (3, 4), were isolated from the rhizomes of Alpinia officinarum. The new compounds were elucidated to be (5S)-5-hydroxy-7-(3, 4-dihydroxyphenyl)-1-phenyl-3-heptanone (1) and (5R)-5-hydroxy-7-(3-methoxy-4, 5-dihydroxyphenyl)-1-phenyl-3-heptanone (2) based on their spectral analysis. Compound 4 showed moderate cytotoxicity against human tumor cell lines, HepG2, MCF-7 and SF-268, while no significant effect were found for compounds 1-3.
An
Ning
N
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China. zhongmeizou@hotmail.com
Zou
Zhong-mei
ZM
Tian
Ze
Z
Luo
Xiu-zhen
XZ
Yang
Shi-lin
SL
Xu
Li-zhen
LZ
D032429:Alpinia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D045744:Cell Line, Tumor; D036381:Diarylheptanoids / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D005909:Glioblastoma / Q000188:drug therapy; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000627:therapeutic use*; D027343:Rhizome
C539193:(5R)-5-hydroxy-7-(3-methoxy-4, 5-dihydroxyphenyl)-1-phenyl-3-heptanone; C539192:(5S)-5-hydroxy-7-(3, 4-dihydroxyphenyl)-1-phenyl-3-heptanone; D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids; D010936:Plant Extracts