title: Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues.
abstract: Disease manifestation, pathology, and tissue tropism following infection with Tioman virus (TioPV), a newly isolated, bat-derived paramyxovirus, was investigated in subcutaneously (n = 12) and oronasally (n = 4) inoculated pigs. Pigs were either asymptomatic or developed pyrexia, but all of the animals produced neutralizing antibodies. The virus (viral antigen and/or genome) was detected in lymphocytes of the thymus, tonsils, spleen, lymph nodes and Peyer's patches (ileum), tonsillar epithelium, and thymic epithelioreticular cells. Virus was isolated from oral swabs but not from urine. Our findings suggest that the pig could act as an intermediate or amplifying host for TioPV and that oral secretion is a possible means of viral transmission.
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Koon Chu
authors.initials: KC
authors.lastname: Yaiw
authors.forename: John
authors.initials: J
authors.lastname: Bingham
authors.forename: Gary
authors.initials: G
authors.lastname: Crameri
authors.forename: Bruce
authors.initials: B
authors.lastname: Mungall
authors.forename: Alex
authors.initials: A
authors.lastname: Hyatt
authors.forename: Meng
authors.initials: M
authors.lastname: Yu
authors.forename: Bryan
authors.initials: B
authors.lastname: Eaton
authors.forename: Devi
authors.initials: D
authors.lastname: Shamala
authors.forename: Lin-Fa
authors.initials: LF
authors.lastname: Wang
authors.forename: Kum
authors.initials: K
authors.lastname: Thong Wong
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D005334:Fever / Q000821:virology; D008198:Lymph Nodes / Q000821:virology; D008214:Lymphocytes / Q000821:virology; D008221:Lymphoid Tissue / Q000821:virology*; D009055:Mouth / Q000821:virology; D009500:Neutralization Tests; D014066:Palatine Tonsil / Q000821:virology; D010252:Paramyxoviridae / Q000276:immunology / Q000472:pathogenicity*; D018184:Paramyxoviridae Infections / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D010581:Peyer's Patches / Q000821:virology; D013154:Spleen / Q000821:virology; D013553:Swine Diseases / Q000821:virology*; D013950:Thymus Gland / Q000821:virology; D014556:Urine / Q000821:virology
chemical_list: D000914:Antibodies, Viral