Hypoxia positron emission tomography imaging with 18f-fluoromisonidazole.
The importance of hypoxia in disease pathogenesis and prognosis is gathering increasing clinical significance and having a greater impact on patient management and outcome. Previous efforts to evaluate hypoxia have included the invasive assessment of hypoxia with immunohistologic and histographic oxygen probes. The emergence of new radiotracers has allowed noninvasive assessment of hypoxia, with the most extensively investigated and validated positron emission tomography radiotracer of hypoxia to date being (18)F-fluoromisonodazole ((18)F-FMISO). This review discusses the relevance and biology of hypoxia in cells and organ systems, and reviews the laboratory and clinical applications of (18)F-FMISO in oncology and noncancer disease states.
Lee
Sze Ting
ST
Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
Scott
Andrew M
AM
D000818:Animals; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000378:metabolism; D015687:Cell Hypoxia; D005462:Fluorine Radioisotopes; D005910:Glioma / Q000000981:diagnostic imaging / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D008920:Misonidazole / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000378:metabolism; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D020521:Stroke / Q000000981:diagnostic imaging* / Q000378:metabolism
D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; C031843:fluoromisonidazole; D008920:Misonidazole