[Influense of stimulation of Substancia Nigra and Nucleus Caudatus on postsynaptic responses of cortical nociceptive neurons].
The aim of the research was to investigate the influence of electric stimulation of Substancia Nigra and Nucleus Caudatus on postsynaptic processes, evoked in the nociceptive neuron of somatosensory cortex of cats. Intracellular recordings of electrical activity of the somatosensory cortex neurons in response to stimulation of the tooth pulp and of ventro-postero-medial (VPM) nucleus of thalamus, revealed the EPSP-peak-IPSP complex. Conditioning stimulation of Substancia Nigra or Nucleus Caudatus, which preceded the test-stimulation of the tooth pulp or VPM, with intervals of 100 to 700 ms, induced 40-50% decrease of IPSP only, in both nociceptive and convergent neurons. The maximal effect in both cases was achieved at an interval of 400-700 ms between conditioning- and test-stimuli. Probably these processes are realized through either pre- or postsynaptic mechanisms.
Tkemaladze
T K
TK
Labukhua
T Sh
TSh
Gurtskaia
G P
GP
Dzhanashia
T K
TK
Abzianidze
E V
EV
D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D008297:Male; D009475:Neurons, Afferent / Q000502:physiology*; D010146:Pain; D013378:Substantia Nigra / Q000502:physiology*; D009435:Synaptic Transmission