Emerging trends in molecular recognition: utility of weak aromatic interactions.
Aromatic interactions play a vital role in chemistry and biology. As about 20% are aromatic in nature, so the role of aromatic interactions become prominent in drug receptor interactions. Not only in drug receptor interactions but also in crystal engineering, protein folding, stacking interactions in DNA/RNA the role of the interactions is of utmost importance. With the emergence of supramolecular chemistry dendrimers, tweezers, rotaxanes, catenanes, and several supramolecular aggregates are associated with aromatic interactions. The mechanism of such interactions is still unknown by the replacement of a small substituent from the aromatic molecule may lead or destroy the interactions. In the present review several models are being discussed with arene interactions under selected heads.
Tewari
Ashish Kumar
AK
Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India. tashish2002@yahoo.com
Dubey
Rashmi
R
D001665:Binding Sites; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D008958:Models, Molecular; D011955:Receptors, Drug; D013329:Structure-Activity Relationship
D006841:Hydrocarbons, Aromatic; D011955:Receptors, Drug