In vitro study of Candida tropicalis isolates exhibiting paradoxical growth in the presence of high concentrations of caspofungin.
Paradoxical growth was noted in RPMI 1640 and antibiotic medium 3 in the case of 14 and 1 of 15 Candida tropicalis strains, respectively, at a caspofungin concentration of 12.5 microg/ml using minimum fungicidal concentration tests. Time-kill assays showed that against isolates killed at lower concentrations, caspofungin at a concentration of 12.5 microg/ml was only fungistatic.
Sóczó
G
G
Department of Medical Microbiology, Medical and Science Center, University of Debrecen, 4032 Debrecen, Nagyerdei, Hungary.
Kardos
G
G
Varga
I
I
Kelentey
B
B
Gesztelyi
R
R
Majoros
L
L
D000935:Antifungal Agents / Q000494:pharmacology; D041022:Candida tropicalis / Q000187:drug effects* / Q000254:growth & development; D000077336:Caspofungin; D054714:Echinocandins / Q000494:pharmacology*; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D013997:Time Factors
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin