title: The long and the short of RNA maps.
abstract: The landscapes of mammalian genomes are characterized by complex patterns of intersecting and overlapping sense and antisense transcription, giving rise to large numbers of coding and non-protein-coding RNAs (ncRNAs). A recent report by Kapranov and colleagues(1) describes three potentially novel classes of RNAs located at the very edges of protein-coding genes. The presence of RNAs from one of these classes appears to be correlated with the expression levels of their associated genes. These results suggest that a proportion of these RNAs might have roles in the cis-regulation of neighbouring protein-coding genes' expression.
authors.affiliation: MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, UK.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ponjavic
authors.forename: Chris P
authors.initials: CP
authors.lastname: Ponting
mesh_terms: D000818:Animals; D004303:Dosage Compensation, Genetic; D019143:Evolution, Molecular; D015870:Gene Expression; D020868:Gene Silencing; D016678:Genome; D015894:Genome, Human; D018392:Genomic Imprinting; D006801:Humans; D008322:Mammals; D035683:MicroRNAs / Q000235:genetics; D008957:Models, Genetic; D014176:Protein Biosynthesis / Q000235:genetics; D012313:RNA / Q000737:chemistry* / Q000145:classification* / Q000235:genetics* / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics; D012342:RNA, Small Nuclear / Q000235:genetics; D020537:RNA, Small Nucleolar / Q000235:genetics; D022661:RNA, Untranslated / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D017423:Sequence Analysis, RNA; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs; D034741:RNA, Small Interfering; D012342:RNA, Small Nuclear; D020537:RNA, Small Nucleolar; D022661:RNA, Untranslated; D012313:RNA