Primary granulomatous angiitis of the central nervous system: findings of magnetic resonance spectroscopy and fractional anisotropy in diffusion tensor imaging prior to surgery. Case report.
Primary granulomatous angiitis of the central nervous system (CNS) is extremely rare. Its preoperative diagnosis is difficult as the condition displays nonspecific features on routine neuroimaging investigations. In this paper, the authors report findings of magnetic resonance (MR) spectroscopy and fractional anisotropy (FA) with diffusion tensor MR imaging in a case of granulomatous angiitis of the CNS. A 30-year-old man presented with morning headaches and grand mal seizures. An MR image revealed a mass resembling glioblastoma in the right temporal lobe. Magnetic resonance spectroscopy showed a high choline/creatine (Cho/Cr) ratio indicative of a malignant neoplasm, accompanied by a slight elevation of glutamate and glutamine. The FA value was very low, which is inconsistent with malignant glioma. The mass was totally removed surgically. Histologically, the peripheral lesion of the mass consisted of a rough accumulation of fat granule cells, infiltration of inflammatory cells, and distribution of capillary vessels. Some vessels within the lesion were replaced by granulomas. The histological diagnosis was granulomatous angiitis of the CNS. The MIB-1-positive rate of the granuloma was approximately 5%. Both MR spectroscopy and FA were unable to accurately diagnose granulomatous angiitis of the CNS prior to surgery; however, elevated Cho/Cr and glutamate and glutamine shown by MR spectroscopy may indicate the moderate proliferation potential of the granuloma and the inflammatory process, respectively, in this condition. Although the low FA value in the present case enabled the authors to rule out a diagnosis of glioblastoma, FA values in inflammatory lesions require careful interpretation.
Beppu
Takaaki
T
Department of Neurosurgery, Iwate Medical University, Morioka, Japan. tbeppu@iwate-med.ac.jp
Inoue
Takashi
T
Nishimoto
Hideaki
H
Nakamura
Shinichi
S
Nakazato
Yoichi
Y
Ogasawara
Kuniaki
K
Ogawa
Akira
A
D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000098:blood supply* / Q000378:metabolism / Q000601:surgery; D002533:Cerebral Angiography; D002794:Choline / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011300:Preoperative Care; D020293:Vasculitis, Central Nervous System / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*
D003404:Creatinine; D002794:Choline