2-epi-botcinin A and 3-O-acetylbotcineric acid from Botrytis cinerea.
Two metabolites, 2-epi-botcinin A and 3-O-acetylbotcineric acid, were isolated from Botrytis cinerea (AEM211). The former compound was new, and the latter was known but structurally revised by us. In a test for antifungal activity against Magnaporthe grisea, a pathogen of rice blast disease, 2-epi-botcinin A was 8 times less active than botcinin A (MIC 100 microM), and the MIC value for 3-O-acetylbotcineric acid being 100 microM.
Sakuno
Emi
E
Department of Agricultural Chemistry, Faculty of Agriculture, Tottori University, Japan.
Tani
Hiroko
H
Nakajima
Hiromitsu
H
D000143:Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020171:Botrytis / Q000737:chemistry* / Q000378:metabolism; D005285:Fermentation; D020082:Magnaporthe / Q000187:drug effects / Q000472:pathogenicity; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010935:Plant Diseases / Q000382:microbiology; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D000143:Acids; D000935:Antifungal Agents; D011753:Pyrones