An efficient and practical synthesis of 2-((1H-indol-3-yl)(aryl)methyl)malononitriles under ultrasound irradiation.
Synthesis of 2-((1H-indol-3-yl)(aryl)methyl)malononitrile via the Michael addition of indole with various arylmethylenemalononitriles was carried out in good yields using anhydrous zinc chloride as the catalyst under ultrasound irradiation.
Li
Ji-Tai
JT
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, No. 88, Hezuo Road, Baoding 071002, Hebei Province, PR China. Electronic address: lijitai@mail.hbu.edu.cn.
Lin
Zhi-Ping
ZP
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, No. 88, Hezuo Road, Baoding 071002, Hebei Province, PR China.
D002384:Catalysis; D002712:Chlorides; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis* / Q000528:radiation effects; D009682:Magnetic Resonance Spectroscopy; D009570:Nitriles / Q000138:chemical synthesis* / Q000528:radiation effects; D014465:Ultrasonics; D017967:Zinc Compounds
D002712:Chlorides; D007202:Indicators and Reagents; D007211:Indoles; D009570:Nitriles; D017967:Zinc Compounds; C016837:zinc chloride