Longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosis.
BACKGROUND
The purpose of this study was to confirm that women with latent toxoplasmosis have developmentally younger fetuses at estimated pregnancy week 16 and to test four exclusive hypotheses that could explain the observed data.


METHODS
In the present retrospective cohort study we analysed by the GLM (general linear model) method data from 730 Toxoplasma-free and 185 Toxoplasma-infected pregnant women.


RESULTS
At pregnancy week 16 estimated from the date of the last menstruation, the mothers with latent toxoplasmosis had developmentally younger fetuses based on ultrasound scan (P = 0.014). Pregnancy of Toxoplasma-positive compared to Toxoplasma-negative women was by about 1.3 days longer, as estimated both from the date of the last menstruation (P = 0.015) and by ultrasonography (P = 0.025).


CONCLUSIONS
The most parsimonious explanation for the observed data is retarded fetal growth during the first weeks of pregnancy in Toxoplasma-positive women. The phenomenon was only detectable in multiparous women, suggesting that the immune system may play some role in it.
Kanková
Sárka
S
Department of Parasitology, Charles University in Prague, Faculty of Science, Vinicná 7, CZ-128 44 Praha 2, Czech Republic. kankova.sarka@seznam.cz
Flegr
Jaroslav
J
D000328:Adult; D000913:Antibodies, Protozoan / Q000032:analysis; D015331:Cohort Studies; D005260:Female; D047109:Fetal Development / Q000502:physiology; D005317:Fetal Growth Retardation / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D016014:Linear Models; D010298:Parity; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000503:physiopathology*; D012189:Retrospective Studies; D013997:Time Factors; D014125:Toxoplasmosis, Congenital / Q000150:complications* / Q000503:physiopathology*; D016216:Ultrasonography, Prenatal
D000913:Antibodies, Protozoan