title: HIV subtypes in Scotland, 2000-2006.
abstract: The purpose of this study was to document the dynamics of HIV-1 subtypes in Scotland over a 6-year period. Viral RNA from all-new diagnoses was amplified by nested PCR and sequenced in the gag and/or env regions. Subtype was assigned by phylogenetic analysis, and aligned with demographic data including likely route and geographical origin of infection. We present data on 80% of all new diagnoses in Scotland between April 2000 and April 2006. Within the background of an expanding epidemic, subtype B predominates in men who have sex with men and intravenous drug users but there is a small but consistent number of UK-acquired infections in these risk groups caused by non-B subtypes. In heterosexuals, non-B subtypes acquired abroad, especially Africa, are still the largest group but again UK-acquired numbers are rising. The social and clinical significance of the spread of non-B subtypes in different ethnic and risk groups remains to be established.
authors.affiliation: Department of Medical Microbiology, Ninewells Hospital, Dundee, Scotland, UK. dave.yirrell@nhs.net
authors.forename: D L
authors.initials: DL
authors.lastname: Yirrell
authors.forename: L
authors.initials: L
authors.lastname: Shaw
authors.forename: E
authors.initials: E
authors.lastname: Campbell
authors.forename: S M
authors.initials: SM
authors.lastname: Burns
authors.forename: S O
authors.initials: SO
authors.lastname: Cameron
authors.forename: D
authors.initials: D
authors.lastname: Goldberg
mesh_terms: D005260:Female; D015752:Genes, env / Q000235:genetics; D015750:Genes, gag / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D017720:Molecular Epidemiology; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D012307:Risk Factors; D012606:Scotland / Q000453:epidemiology
chemical_list: D012367:RNA, Viral