title: Relationship between detectability of ischemic lesions by diffusion-weighted imaging and embolic sources in transient ischemic attacks.
abstract: OBJECTIVE
  The aim of this study is to clarify the relationship between lesion detectability by diffusion-weighted magnetic resonance imaging (DWI) and the etiology of transient ischemic attacks (TIAs).
  
  
  METHODS
  A retrospective study was performed on 72 patients with carotid TIAs who underwent DWI studies within 2 weeks after the last episode.
  
  
  RESULTS
  Lesions were detected in 24 of 72 patients (33%). The detectability of lesions was 12% (3/25) in the large-artery atherosclerosis (LA) group, 57% (8/14) in the cardioembolism (CE) group, 8% (1/13) in the small-artery occlusion (SA) group, and 60% (12/20) in the other etiology or undetermined etiology (UD) group. Detectabilities in the CE group and the UD group were higher than those in the LA and SA groups. Of 24 patients with DWI-positive lesions, 17 (71%) had embolic sources in the heart; 9 were classified in the UD group because they had embolic sources both in the heart and large artery.
  
  
  CONCLUSIONS
  Ischemic DWI lesions in TIAs are most likely caused by a cardioembolic mechanism. In TIA patients showing lesions on DWI, heart disease should be surveyed as the possible embolic source.
authors.affiliation: Department of Cerebrovascular Medicine, National Cardiovascular Center, Suita, Japan.
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Uno
authors.forename: Akihiko
authors.initials: A
authors.lastname: Taguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Oe
authors.forename: Keiko
authors.initials: K
authors.lastname: Nagano
authors.forename: Naoaki
authors.initials: N
authors.lastname: Yamada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moriwaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Naritomi
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D002544:Cerebral Infarction / Q000473:pathology*; D016009:Chi-Square Distribution; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004617:Embolism / Q000150:complications*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D002546:Ischemic Attack, Transient / Q000175:diagnosis* / Q000209:etiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors