title: Plasma concentrations of selected organobromine compounds and polychlorinated biphenyls in postmenopausal women of Québec, Canada.
abstract: BACKGROUND
  Brominated flame retardants, especially polybrominated diphenyl ethers (PBDEs), have been widely used in North America, but little is known about the level of exposure of human populations to these compounds.
  
  
  OBJECTIVE
  We set out to assess the internal exposure of postmenopausal Canadian women to selected organobromine compounds and to investigate factors associated with this exposure.
  
  
  METHODS
  We measured concentrations of four PBDEs, one polybrominated biphenyl, and for comparative purposes, 41 polychlorinated biphenyl (PCB) congeners in plasma samples from 110 healthy postmenopausal women who were recruited at a mammography clinic in 2003-2004.
  
  
  RESULTS
  PBDE-47 was the major PBDE congener, with a mean (geometric) concentration of 8.1 ng/g lipids and extreme values reaching 1,780 ng/g. By comparison, the mean concentration of the major PCB congener (PCB-153) was 41.7 ng/g and the highest value was 177 ng/g. PBDEs 47, 99, and 100 were strongly intercorrelated, but weaker correlations were noted with PBDE-153. As the sum of PBDEs (summation operatorPBDEs) increased, the relative contribution of PBDE-47 to the summation operatorPBDEs increased, whereas that of PBDE-153 decreased. PBDE-153 was the only brominated compound correlated to PCB-153. PBDE levels were not linked to any sociodemographic, anthropometric, reproductive, or lifestyle variables documented in the present study. Age and body mass index gain since the age of 18 years were significant predictors of PCB-153 plasma levels.
  
  
  CONCLUSIONS
  Our results suggest that exposure to PBDE-47 likely occurs through direct contact with the penta-PBDE formulation, whereas exposure to PBDE-153 may originate in part from the food chain.
authors.affiliation: Unité de recherche en santé publique, Centre hospitalier universitaire de Québec and Université Laval, Québec, Québec, Canada.
authors.forename: Torkjel M
authors.initials: TM
authors.lastname: Sandanger
authors.forename: Marc
authors.initials: M
authors.lastname: Sinotte
authors.forename: Pierre
authors.initials: P
authors.lastname: Dumas
authors.forename: Mario
authors.initials: M
authors.lastname: Marchand
authors.forename: Courtney D
authors.initials: CD
authors.lastname: Sandau
authors.forename: Daria
authors.initials: D
authors.lastname: Pereg
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bérubé
authors.forename: Jacques
authors.initials: J
authors.lastname: Brisson
authors.forename: Pierre
authors.initials: P
authors.lastname: Ayotte
mesh_terms: D017605:Bromine Compounds / Q000097:blood*; D004781:Environmental Exposure / Q000009:adverse effects*; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D005260:Female; D020387:Food Chain; D055768:Halogenated Diphenyl Ethers; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000097:blood*; D008875:Middle Aged; D010647:Phenyl Ethers / Q000097:blood*; D011075:Polybrominated Biphenyls / Q000097:blood*; D011078:Polychlorinated Biphenyls / Q000097:blood; D017698:Postmenopause; D011792:Quebec / Q000453:epidemiology
chemical_list: D017605:Bromine Compounds; D055768:Halogenated Diphenyl Ethers; D006842:Hydrocarbons, Brominated; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; C511295:2,2',4,4'-tetrabromodiphenyl ether; D011078:Polychlorinated Biphenyls; C478854:2,2',4,4',5,5'-hexabrominated diphenyl ether