Novel synthetic ligands for targeted PET imaging and radiotherapy of copper.
Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA-Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with (64)Cu, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA-Bn form stable complexes with (64)Cu.
Chong
Hyun-Soon
HS
Chemistry Division, Biological, Chemical, and Physical Science Department, Illinois Institute of Technology, 3101 S. Dearborn Street, Chicago, IL 60616, USA. Chong@iit.edu
Mhaske
Santosh
S
Lin
Mai
M
Bhuniya
Sankar
S
Song
Hyun A
HA
Brechbiel
Martin W
MW
Sun
Xiankai
X
D000818:Animals; D003301:Copper Radioisotopes / Q000737:chemistry*; D004355:Drug Stability; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods*; D011878:Radiotherapy; D051381:Rats; D044967:Serum / Q000737:chemistry
D003301:Copper Radioisotopes; D008024:Ligands; D009942:Organometallic Compounds