Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.
We investigated the antitumor effect of survivin DNA vaccine in murine pancreatic and lymphoma models, and if xenogenic survivin can generate stronger immune response. We found that mice vaccinated with either human or mouse survivin DNA have significantly slower tumor growth and longer survival than those vaccinated with vector DNA. There was no significant difference between groups that received human and mouse survivin DNA. Lymphocyte infiltration was greater in tumors of mice immunized with survivin DNA than in tumors of control mice. We conclude that survivin DNA vaccine generated specific antitumor effects with increased lymphocyte infiltration at the tumor sites.
Zhu
Kuichun
K
Department of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, United States.
Qin
Hong
H
Cha
Soung-Chul
SC
Neelapu
Sattva S
SS
Overwijk
Willem
W
Lizee
Gregory A
GA
Abbruzzese
James L
JL
Hwu
Patrick
P
Radvanyi
Laszlo
L
Kwak
Larry W
LW
Chang
David Z
DZ
D000818:Animals; D019496:Cancer Vaccines / Q000235:genetics / Q000276:immunology*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008214:Lymphocytes / Q000276:immunology; D008223:Lymphoma / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000276:immunology*; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology / Q000517:prevention & control; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D012097:Repressor Proteins; D000077022:Survivin; D019444:Vaccines, DNA / Q000235:genetics / Q000276:immunology*
C107489:BIRC5 protein, human; C117749:Birc5 protein, mouse; D019496:Cancer Vaccines; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D012097:Repressor Proteins; D000077022:Survivin; D019444:Vaccines, DNA