title: Cytotoxic lignans from the stem bark of Magnolia officinalis.
abstract: Three new lignans, 4'-methoxymagndialdehyde ( 1), 4'-methoxymagnaldehyde B ( 2), and 4'-methoxymagnaldehyde E ( 3), were isolated from hexane- and EtOAc-soluble fractions of the stem bark of Magnolia officinalis, together with eight known compounds ( 4- 11). The structures of compounds 1- 3 were determined on the basis of spectroscopic and physicochemical data analysis. Compounds 1- 11 were tested in vitro for their cytotoxic activity against the K562, HeLa, and A549 cancer cell lines. Among the compounds tested, compound 1 showed the most potent cytotoxic activity against these cancer cell lines, with IC50 values of 3.9, 1.5, and 3.7 microg/mL, respectively.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
authors.forename: Ui-Joung
authors.initials: UJ
authors.lastname: Youn
authors.forename: Quan Cheng
authors.initials: QC
authors.lastname: Chen
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Jin
authors.forename: Ik-Soo
authors.initials: IS
authors.lastname: Lee
authors.forename: Hong-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jong-Pill
authors.initials: JP
authors.lastname: Lee
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Chang
authors.forename: Byung-Sun
authors.initials: BS
authors.lastname: Min
authors.forename: Ki-Hwan
authors.initials: KH
authors.lastname: Bae
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007723:Korea; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031566:Magnolia / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: C524952:4'-methoxymagnaldehyde B; C524953:4'-methoxymagnaldehyde E; C524951:4'-methoxymagndialdehyde; D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans