title: Malignant rhabdoid tumor mimicking hepatoblastoma: a case report and literature review.
abstract: Hepatoblastoma accounts for the vast majority of malignant primary liver tumors in infancy. In contrast, rhabdoid tumors arising in the liver are extremely rare, but they can share clinical and histologic features with hepatoblastoma and can create diagnostic confusion, especially when one is dealing with small biopsies. In this case report we demonstrate that immunohistochemical and molecular techniques can identify the characteristic loss of INI1 and facilitate making the correct diagnosis of primary hepatic malignant rhabdoid tumor. Important similarities and differences between hepatoblastoma and rhabdoid tumors are reviewed, and suggestions are offered to help distinguish these 2 tumor types.
authors.affiliation: Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. lars.wagner@cchmc.org
authors.forename: Lars M
authors.initials: LM
authors.lastname: Wagner
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Garrett
authors.forename: Edgar T
authors.initials: ET
authors.lastname: Ballard
authors.forename: D Ashley
authors.initials: DA
authors.lastname: Hill
authors.forename: Arie
authors.initials: A
authors.lastname: Perry
authors.forename: Jaclyn A
authors.initials: JA
authors.lastname: Biegel
authors.forename: Margaret H
authors.initials: MH
authors.lastname: Collins
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D018197:Hepatoblastoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary*; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D010534:Peritoneal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000556:secondary; D011247:Pregnancy; D047928:Premature Birth; D018335:Rhabdoid Tumor / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D000071796:SMARCB1 Protein; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014178:Translocation, Genetic
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; D014157:Transcription Factors