Immunoreceptor-like signaling by beta 2 and beta 3 integrins.
Although adhesion to extracellular structures is one of the most fundamental cell biological processes, the intracellular signals triggered by integrins, the most important receptors involved, are incompletely understood. Several recent reports indicate that signaling by beta(2) and beta(3) integrins in various cell types (neutrophils, macrophages, osteoclasts and platelets) use components of the signal transduction machinery of lymphocyte antigen receptors. Central to this immunoreceptor-like signaling is the phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters (such as DAP12 and the Fc receptor gamma-chain) by Src-family kinases and the concomitant recruitment of the Syk tyrosine kinase through its dual SH2 domains. These and other reports reveal an unexpected similarity between the signal-transduction mechanisms used by integrins and immune recognition receptors.
Jakus
Zoltán
Z
Department of Physiology, Semmelweis University School of Medicine, 1088 Budapest, Hungary.
Fodor
Szabina
S
Abram
Clare L
CL
Lowell
Clifford A
CA
Mócsai
Attila
A
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D018821:CD18 Antigens / Q000737:chemistry / Q000378:metabolism*; D002448:Cell Adhesion; D006801:Humans; D039661:Integrin beta3 / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011487:Protein Conformation; D011946:Receptors, Antigen / Q000737:chemistry / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000378:metabolism; D018909:src Homology Domains; D019061:src-Family Kinases / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D018821:CD18 Antigens; D039661:Integrin beta3; D011946:Receptors, Antigen; D011971:Receptors, Immunologic; D051746:ZAP-70 Protein-Tyrosine Kinase; D019061:src-Family Kinases