title: Role of oxidative stress in mechanisms of premature aging in shift labor workers.
abstract: There have been examined 90 practically healthy male-shift-workers 21-58 aged and 21-60 aged (average age 41.4 +/- 1.4 and 48.6 +/- 1.3) who worked for a long period of time in the North on shift at the enterprises of JS "Yamburggasdobycha" at the moment of examination. It was revealed a high content of glycosaminoglycans (GAG) in blood serum (2.20 +/- 0.12 mmol/l), accumulation of LPO products (3.45 +/- 0.18 nmol MDA/ml) against the background of decreased glutationreductase activity (0.38 +/- 0.04 mkmol/l hour). Level of total cholesterol was increased at standard content of HDL (6.1+0.2). It can be concluded that definition of GAG and MDA in blood is one of the significant criteria, reflecting adaptative tension and premature aging of shift-workers.
authors.affiliation: Scientific Center of Clinical and Experimental Medicine SB RAMS, Novosibirsk, Russia.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Kulikov
authors.forename: Yu M
authors.initials: YM
authors.lastname: Fridman
authors.forename: A N
authors.initials: AN
authors.lastname: Fomin
mesh_terms: D000328:Adult; D000367:Age Factors; D019588:Aging, Premature / Q000503:physiopathology*; D002940:Circadian Rhythm; D003238:Connective Tissue; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D009790:Occupations; D018384:Oxidative Stress; D010561:Personnel Staffing and Scheduling; D012307:Risk Factors; D013997:Time Factors; D014940:Work Schedule Tolerance; D017132:Workplace