Serum HDL-cholesterol in women using low dose oral contraceptives.
This study was done to appraise the effects of low-dose oral contraceptives (OCs) containing 30microgm ethinyl estradiol and 150microgm levonorgestrel on lipid metabolism by a lipid variable-serum HDL-cholesterol (HDL-C). HDL-C has been identified as a lipoprotein that protects against atherosclerosis and its levels are inversely proportional to the risk for developing ischemic coronary disease and venous thromboembolic disorders. Ninety young women within reproductive age group were picked for this study. Sixty women using low-dose oral contraceptives served as experimental group and thirty age matched hormonal contraceptive non users were selected for control group. Experimental group was again subdivided into OCs users for last one-year group, three-year group and five-year group. The result showed that there was no significant difference on serum HDL-cholesterol levels between users & non-users women. It is concluded that low-dose oral contraceptives regimens did not significantly affect the lipid metabolism. It can be safely used as contraceptive & non-contraceptive purposes. The value of studied parameter for serial longer duration of OCs uses needs to be assessed.
Nessa
A
A
Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh. nessa_akhtarun @yahoo.com
Latif
S A
SA
Uddin
M M
MM
Hussain
M A
MA
D000328:Adult; D000367:Age Factors; D008076:Cholesterol, HDL / Q000097:blood* / Q000187:drug effects; D003276:Contraceptives, Oral / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D017202:Myocardial Ischemia; D011446:Prospective Studies; D012307:Risk Factors; D054556:Venous Thromboembolism
D008076:Cholesterol, HDL; D003276:Contraceptives, Oral; D004997:Ethinyl Estradiol; D016912:Levonorgestrel