title: New cytologic clues in localized Leishmania lymphadenitis.
abstract: OBJECTIVE
  To describe new cytologic clues to diagnose localized leishmania lymphadenitis (LLL).
  
  
  METHODS
  The study examined cytologic smears of 170 cases of LLL referred to our department from November 1989 to October 2004. A total of 120 cases were confirmed by detecting Leishman-Donovan (LD) bodies in at least 1 of the cytologic smears and 50 cases, which were histologically confirmed. For comparison we studied cytologic smears of 20 cases of tuberculous lymphadenitis, 20 cases of toxoplasma lymphadenitis and 20 cases of granulomatous lymphadenitis of unspecified causes.
  
  
  RESULTS
  Cases were divided into 4 major groups. Cytologic findings in these groups were studied to find highly suggestive clues. Cytologic findings present in most of these groups, but absent or very rare in other granulomatous lymphadenitis, were LD kinetoplasts, plasma cells with different shapes of inclusions and lymphogranular bodies. Rare findings not reported previously were: intraneutrophilic LD bodies, hematoxylin body-like inclusions, fibroblasts, cytoplasmic blebbing and floating parasitophorous vacuoles.
  
  
  CONCLUSIONS
  Despite previous reports emphasizing detecting LD bodies in diagnosing LLL, we present cytologic clues highly suggestive of this self-limited disease when LD bodies cannot be detected or are very few on the smears.
authors.affiliation: Department of Cytopathology and Hematopathology, Dr. Daneshbod Pathology Laboratory, Shiraz School of Medicine, Shiraz, Iran. daneshbk@yahoo.com
authors.forename: Yahya
authors.initials: Y
authors.lastname: Daneshbod
authors.forename: Khosrow
authors.initials: K
authors.lastname: Daneshbod
authors.forename: Bijan
authors.initials: B
authors.lastname: Khademi
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Negahban
authors.forename: Gholam-Reza
authors.initials: GR
authors.lastname: Bedayat
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D007891:Leishmania / Q000502:physiology*; D008199:Lymphadenitis / Q000175:diagnosis* / Q000469:parasitology*; D008297:Male; D008875:Middle Aged; D010271:Parasites / Q000502:physiology; D010950:Plasma Cells / Q000473:pathology; D014388:Tuberculosis, Lymph Node / Q000469:parasitology / Q000473:pathology