Targeted alpha-particle radiotherapy with 211At-labeled monoclonal antibodies.
An attractive feature of targeted radionuclide therapy is the ability to select radionuclides and targeting vehicles with characteristics that are best suited for a particular clinical application. One combination that has been receiving increasing attention is the use of monoclonal antibodies (mAbs) specifically reactive to receptors and antigens that are expressed in tumor cells to selectively deliver the alpha-particle-emitting radiohalogen astatine-211 (211At) to malignant cell populations. Promising results have been obtained in preclinical models with multiple 211At-labeled mAbs; however, translation of the concept to the clinic has been slow. Impediments to this process include limited radionuclide availability, the need for suitable radiochemistry methods operant at high activity levels and lack of data concerning the toxicity of alpha-particle emitters in humans. Nonetheless, two clinical trials have been initiated to date with 211At-labeled mAbs, and others are planned for the near future.
Zalutsky
Michael R
MR
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA. zalut001@mc.duke.edu
Reardon
David A
DA
Pozzi
Oscar R
OR
Vaidyanathan
Ganesan
G
Bigner
Darell D
DD
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001246:Astatine / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000639:trends*; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D016499:Radioimmunotherapy / Q000639:trends*; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal; D019275:Radiopharmaceuticals; D001246:Astatine