The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1.
Compartmentalized distribution of functional components is a hallmark of the eukaryotic nucleus. Technological advances in recent years have provided unprecedented insights into the role of chromatin organization and interactions of various structural-functional components toward gene regulation. SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation. Studies in recent years have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFNgamma treatment on chromatin loop architecture of the MHC class-I locus and altered expression of genes within the locus. At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin.
Galande
Sanjeev
S
National Centre for Cell Science, Ganeshkhind, Pune 411007, India. sanjeev@nccs.res.in
Purbey
Prabhat Kumar
PK
Notani
Dimple
D
Kumar
P Pavan
PP
D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D036961:Matrix Attachment Region Binding Proteins / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*
D002843:Chromatin; D036961:Matrix Attachment Region Binding Proteins; C076189:SATB1 protein, human