title: Obesity and the metabolic syndrome in Mediterranean countries: a hypothesis related to olive oil.
abstract: In Mediterranean countries people would previously have consumed a diet with a high proportion of MUFA. Physical activity would have been intense with a low level of stress. The stearoyl-CoA desaturase (SCD1) system selected over thousands of years of this type of behavior must have adapted to a particular capacity of self regulation. Now, this pattern, called the "Mediterranean diet", has been broken and many people living by the Mediterranean consume a high quantity of calories, mainly from saturated or n-6-rich fats and the relative intake of MUFA has decreased. Simultaneously, physical activity has decreased and the pattern of stress has changed towards what is called a western lifestyle. In this new context, if people have a favorable, genetically conditioned SCD1 activity that will let them confront the new situation or else have some other compensatory mechanism, such as being keen on sport, etc, then they can prevent the appearance of some of the complications associated with the metabolic syndrome. If, on the other hand, the SCD1 pattern is genetically unfavorable for this new situation and they have a new cultural context, then they do not have the alternative compensatory mechanisms and the probability of developing the metabolic syndrome is high.
authors.affiliation: Service of Endocrinology and Nutrition, Hospital Universitario Carlos Haya (Fundación Imabis), Málaga, Spain. federico.soriguer.sspa@juntadeandalucia.es
authors.forename: Federico
authors.initials: F
authors.lastname: Soriguer
authors.forename: Gemma
authors.initials: G
authors.lastname: Rojo-Martínez
authors.forename: Fernando Rodriguez
authors.initials: FR
authors.lastname: de Fonseca
authors.forename: Eva
authors.initials: E
authors.lastname: García-Escobar
authors.forename: Eduardo
authors.initials: E
authors.lastname: García Fuentes
authors.forename: Gabriel
authors.initials: G
authors.lastname: Olveira
mesh_terms: D000273:Adipose Tissue / Q000254:growth & development; D038441:Diet, Mediterranean; D004777:Environment; D043371:Fatty Acids, Omega-6; D006801:Humans; D008055:Lipids / Q000097:blood; D019083:Mediterranean Region / Q000453:epidemiology; D024821:Metabolic Syndrome / Q000453:epidemiology*; D009765:Obesity / Q000453:epidemiology* / Q000235:genetics; D000069463:Olive Oil; D010938:Plant Oils / Q000737:chemistry; D013230:Stearoyl-CoA Desaturase / Q000235:genetics / Q000502:physiology
chemical_list: D043371:Fatty Acids, Omega-6; D008055:Lipids; D000069463:Olive Oil; D010938:Plant Oils; C523776:SCD1 protein, human; D013230:Stearoyl-CoA Desaturase