Effect of homocysteine on bone mineral density of rats.
The relationship between plasma levels of homocysteine (Hcy) and femur bone mineral density (BMD) was studied in Wistar rats. After 8 weeks of treatment with 0.5 and 1.0 g kg(-1) day(-1) l-methionine the mean plasma levels of Hcy were 7.67 +/- 1.25 and 61.2 +/- 11.4 micromol/l, respectively. Only rats treated with the higher dose had Hcy levels significantly higher than those of controls, 6.38 +/- 0.90 micromol/l (p < 0.001). Dual Energy X-ray Absorptiometry was used to measure the BMD, which was significantly lower only in the animals with the highest plasma levels of Hcy (p < 0.001). This led us to conclude that increased levels of Hcy are associated with risk of decreased BMD.
Soyupek
Feray
F
Department of Physical Medicine and Rehabilitation, Süleyman Demirel University School of Medicine, Isparta 32260, Turkey. feraysoyupek@yahoo.com
Cerci
Sureyya
S
Yildiz
Sedat
S
Yildiz
Mustafa
M
Gumus
Burcin
B
D015502:Absorptiometry, Photon / Q000379:methods; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D006710:Homocysteine / Q000097:blood / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008715:Methionine / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D006710:Homocysteine; D008715:Methionine