Intravitreal ranibizumab (Lucentis) for choroidal neovascularization associated with Stargardt's disease.
OBJECTIVE
To describe a young patient with choroidal neovascularization, associated with Stargardt's disease, who underwent treatment with intravitreal ranibizumab.


METHODS
A 26-year-old man with a diagnosis of Stargard's disease presented at our department for sudden decreased vison in his right eye (20/800). Upon a complete oplthamologic examination, including fluorescein angiography (FA), indocyanine green angiography (ICGA) and optical coherence tomography (OCT), the patient was diagnosed with subfoveal CNV of the right eye. Owing to the subfoveal localization of the CNV, intravitreal ranibizumab injection was performed on this young patient.


RESULTS
Three months after the last intravitreal injection of ranibizumab, fundus biomicroscopy, FA, ICGA and OCT revealed the CNV closure and total resolution of the associated cistoid macular edema and serous retinal detachment, with no recurrence and no complication from the intravitreal injection of ranibizumab. Visual acuity improved only to 20/400.


CONCLUSIONS
Intravitreal ranibizumab injection seems to induce total regression of CNV complicating Stargardt's disease. Further investigations are required to confirm our results.
Querques
Giuseppe
G
Department of Ophthalmology, Ospedali Riuniti, University of Foggia, Foggia, Italy. giuseppe.querques@hotmail.it
Bocco
Maria Cecilia Angulo
MC
Soubrane
Gisele
G
Souied
Eric H
EH
D000328:Adult; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D004396:Coloring Agents; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D007267:Injections; D008268:Macular Degeneration / Q000150:complications*; D008297:Male; D000069579:Ranibizumab; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D014822:Vitreous Body
D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D004396:Coloring Agents; D007208:Indocyanine Green; D000069579:Ranibizumab