title: Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome.
abstract: Oral lichen planus (OLP) and burning mouth syndrome (BMS) are chronic conditions affecting the oral mucosa characterized by pain and burning sensation. Saliva plays a significant role in the maintenance of physical and functional integrity of normal oral mucosa. Identification of potential "salivary biomarkers" for early diagnosis and/or monitoring of human diseases is being explored. We investigated the soluble forms of innate immune associated proteins CD14 and toll-like receptor-2 in unstimulated whole saliva (UWS) as potential biomarkers for OLP and BMS. Our results suggest that the levels of sCD14 and sTLR-2 in UWS were upregulated in OLP and BMS respectively. In addition, oral epithelial cells in the saliva of patients with OLP and BMS exhibited elevated levels of CD14 mRNA and decreased levels of TLR-2 mRNA. Interestingly, presence of co-existent oral candidiasis nullified these changes.
authors.affiliation: Department of Oral Pathology, Medicine and Radiology, Indiana University School of Dentistry, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA. mysriniv@iupui.edu
authors.forename: Mythily
authors.initials: M
authors.lastname: Srinivasan
authors.forename: Krithika N
authors.initials: KN
authors.lastname: Kodumudi
authors.forename: Susan L
authors.initials: SL
authors.lastname: Zunt
mesh_terms: D015415:Biomarkers; D002054:Burning Mouth Syndrome / Q000276:immunology* / Q000382:microbiology; D002180:Candidiasis, Oral / Q000276:immunology / Q000382:microbiology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004847:Epithelial Cells / Q000276:immunology; D005260:Female; D005620:Freund's Adjuvant / Q000276:immunology; D006801:Humans; D017676:Lichen Planus, Oral / Q000276:immunology* / Q000382:microbiology; D018950:Lipopolysaccharide Receptors / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology; D008297:Male; D009061:Mouth Mucosa / Q000276:immunology / Q000382:microbiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012463:Saliva / Q000276:immunology* / Q000382:microbiology; D051195:Toll-Like Receptor 2 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018950:Lipopolysaccharide Receptors; D012333:RNA, Messenger; D051195:Toll-Like Receptor 2; D005620:Freund's Adjuvant