Caudate structural abnormalities in idiopathic normal pressure hydrocephalus.
BACKGROUND - Idiopathic normal pressure hydrocephalus (iNPH) is a reversible dementia in which fronto-striatal cognitive deficits and apathy may be present. OBJECTIVES - The study investigated structural volumetric changes in iNPH, apart from ventriculomegaly. MATERIALS AND METHODS - A full-brain voxel-based morphometric analysis between 11 iNPH patients and 14 healthy controls identified regions of interest (ROIs) for manual volumetric analyses. RESULTS - Caudate and corpus callosum ROI measurements revealed diminished caudate nuclei volume in the iNPH group. CONCLUSIONS - The role of the caudate nucleus in cognitive and affective changes in iNPH should now be explored.
DeVito
E E
EE
Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Salmond
C H
CH
Owler
B K
BK
Sahakian
B J
BJ
Pickard
J D
JD
D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000473:pathology* / Q000503:physiopathology; D001480:Basal Ganglia Diseases / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D002421:Caudate Nucleus / Q000473:pathology* / Q000503:physiopathology; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D003337:Corpus Callosum / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted; D019586:Intracranial Hypertension / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D020547:Lateral Ventricles / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests