title: Serum carboxy-terminal propeptide of type I procollagen (PIP) is a marker of diastolic dysfunction in patients with early type 2 diabetes mellitus.
abstract: This study was designed to investigate whether the serum concentration of the carboxy-terminal propeptide of procollagen type I (PIP), a marker of myocardial fibrosis, is related to changes of the ventricular filling dynamics in patients with early type 2 diabetes mellitus (T2DM). The T2DM group had lower mitral and tricuspid E/A ratios than the control group. Serum PIP was higher in patients with T2DM than in controls (131.1+/-45.6 vs. 109.3+/-32.5 ng/mL, p=0.039). A-Ar, an estimate of passive diastolic function, was inversely related to serum PIP levels in T2DM (r=-0.42, p=0.03). These results show a relation between LV diastolic function and serum PIP levels in early T2DM.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Ihm
authors.forename: Ho-Joong
authors.initials: HJ
authors.lastname: Youn
authors.forename: Dong-Il
authors.initials: DI
authors.lastname: Shin
authors.forename: Sung-Won
authors.initials: SW
authors.lastname: Jang
authors.forename: Chul-Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Pum Joon
authors.initials: PJ
authors.lastname: Kim
authors.forename: Hee-Yeol
authors.initials: HY
authors.lastname: Kim
authors.forename: Kiyuk
authors.initials: K
authors.lastname: Chang
authors.forename: Ki-Bae
authors.initials: KB
authors.lastname: Seung
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Kim
authors.forename: Kyu-Bo
authors.initials: KB
authors.lastname: Choi
mesh_terms: D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D006801:Humans; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000150:complications / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C042813:procollagen type I carboxy terminal peptide