title: Effect of orally administered Eriobotrya japonica seed extract on allergic contact dermatitis in rats.
abstract: The anti-allergic activity of Eriobotrya japonica seeds extract (ESE) was investigated. Oral administration of ESE dramatically inhibited ear swelling due to allergic contact dermatitis caused by repeated application of two antigens, 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone) and dinitrofluorobenzene (DNFB), respectively. The increase of histamine content in inflamed ear tissue induced by oxazolone and DNFB was significantly antagonized by orally administered ESE. Eosinophil peroxidase and myeloperoxidase activity in both models was suppressed by orally administered ESE. Tumour necrosis factor-alpha in the inflamed region caused by repeated application of DNFB was also significantly suppressed. The findings suggest that ESE may be effective for treating allergic contact dermatitis.
authors.affiliation: Department of Biomedical Science, Kochi Medical Graduate School, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan. sungc2004@yahoo.com.cn
authors.forename: Guangchen
authors.initials: G
authors.lastname: Sun
authors.forename: Yixiu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takuma
authors.forename: Masahide
authors.initials: M
authors.lastname: Onogawa
authors.forename: Junko
authors.initials: J
authors.lastname: Yokota
authors.forename: Atsuhide
authors.initials: A
authors.lastname: Hamada
authors.forename: Saburo
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kusunose
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Miyamura
authors.forename: Shojiro
authors.initials: S
authors.lastname: Kyotani
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nishioka
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy*; D004139:Dinitrofluorobenzene; D047209:Eosinophil Peroxidase / Q000187:drug effects / Q000378:metabolism; D031983:Eriobotrya / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D008516:Medicine, Chinese Traditional; D010080:Oxazoles; D009195:Peroxidase / Q000187:drug effects / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: C119678:4-ethoxymethylene-2-phenyl-2-oxazoline-5-one; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D010080:Oxazoles; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D004139:Dinitrofluorobenzene; D047209:Eosinophil Peroxidase; D009195:Peroxidase