title: Postischemic administration of HMG CoA reductase inhibitor inhibits infarct expansion after transient middle cerebral artery occlusion.
abstract: Infarcts expand over a period of several days after focal cerebral ischemia. Inhibition of infarct expansion would be a promising strategy for the protection of the brain after ischemic insult. In this study, we examined the effect of statin treatment initiated 2 days after transient occlusion of the middle cerebral artery for 80 min. Treatment with continuous infusion of pravastatin with an osmotic minipump for 6 days resulted in a significantly smaller infarct volume and better recovery of motor function at 8 days after ischemia compared to vehicle treatment. These results suggest that statin treatment during the postischemic period may be effective in stroke patients.
authors.affiliation: Osaka Neurological Institute, Toyonaka, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Sugiura
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yagita
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sasaki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Todo
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Terasaki
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohyama
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kitagawa
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology / Q000473:pathology; D002545:Brain Ischemia / Q000201:enzymology / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D006903:Hydroxymethylglutaryl CoA Reductases / Q000187:drug effects; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000201:enzymology / Q000473:pathology* / Q000517:prevention & control; D008297:Male; D017035:Pravastatin / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006903:Hydroxymethylglutaryl CoA Reductases; D017035:Pravastatin