title: Association of p53 codon 72 polymorphism with endometriosis.
abstract: OBJECTIVE
  To study the association of endometriosis with p53 codon 72 polymorphism in the population of central Italy and to search for possible interaction with the PTPN22 polymorphism.
  
  
  METHODS
  Study of p53 and PTPN22 polymorphisms in women with endometriosis. Analysis of PTPN22 genotype distribution in relation to p53 genotypes.
  
  
  METHODS
  Department of Obstetrics and Gynecology of the University of Rome "Tor Vergata."
  
  
  METHODS
  The study included 129 women with endometriosis and 147 controls from the Caucasian population of central Italy.
  
  
  METHODS
  None.
  
  
  METHODS
  Evaluation of risk for endometriosis.
  
  
  RESULTS
  No significant difference in the distribution of p53 codon 72 genotypes was observed between endometriosis patients and controls. An interaction between p53 and PTPN22 was observed: a protective action by the Arg/Arg genotype against endometriosis seems to be present only in carriers of the ( *)T allele of PTPN22.
  
  
  CONCLUSIONS
  The negative association between the Arg/Arg genotype of p53 codon 72 found in Chinese people has not been observed in Japanese and Italian populations. Interaction with genes showing different allele frequencies among ethnic groups could be responsible for the differences reported among human populations concerning the relationship between p53 and susceptibility to endometriosis.
authors.affiliation: Division of Obstetrics and Gynecology, Department of Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Ammendola
authors.forename: Fulvia
authors.initials: F
authors.lastname: Gloria-Bottini
authors.forename: Francesco
authors.initials: F
authors.lastname: Sesti
authors.forename: Emilio
authors.initials: E
authors.lastname: Piccione
authors.forename: Egidio
authors.initials: E
authors.lastname: Bottini
mesh_terms: D003062:Codon; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D011110:Polymorphism, Genetic; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22