Investigations to the synthesis of n.c.a. [18F]FClO3 as electrophilic fluorinating agent.
An approach to synthesize the electrophilic fluorinating agent no-carrier-added (n.c.a.) [18F]perchloryl fluoride ([18F]FClO3) in superacidic media in the presence of KClO4 or anhydrous perchloric acid starting from [18F]fluoride was demonstrated in this study. However, the radiochemical yields were low (1-6%) and poorly reproducible. Fluorosulphonic acid proved to be an essential intermediate as revealed by non-radioactive experiments. A key problem in the preparation of [18F]FClO3 is the assumed kinetic inhibition due to the unfavourable stoichiometric ratio of the ClO4 moiety to [18F]HSO3F.
Hiller
A
A
Institute of Interdisciplinary Isotope Research, Permoserstrasse 15, D-04318 Leipzig, Germany. hiller@iif-leipzig.de
Fischer
C
C
Jordanova
A
A
Patt
J T
JT
Steinbach
J
J
D004563:Electrochemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006801:Humans; D010472:Perchlorates / Q000138:chemical synthesis* / Q000737:chemistry; D049268:Positron-Emission Tomography; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
D005462:Fluorine Radioisotopes; D010472:Perchlorates; D019275:Radiopharmaceuticals