title: pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia.
abstract: OBJECTIVE
  To analyze the behavior of pH and sodium bicarbonate (NAHCO3) in the saliva of patients with leukemia during the administration protocol for Methotrexate (Mtx).
  
  
  METHODS
  A controlled clinical essay was carried out on 23 patients between 4 and 18 years of age with high-risk Acute Lymphoblastic Leukemia. Sampling was carried out at To: basal condition; T1: 12 hours after intravenous administration of sodium bicarbonate, before administering Mtx and T2: 3 hours after administering Mtx, the time of maximum concentration. Chiron-Diagnostic 378 equipment was used to determine pH and sodium bicarbonate. The data was interpreted using Analysis of Variance at the 5% significance level.
  
  
  RESULTS
  The highest values of sodium bicarbonate were observed at T2, with salivary pH levels remaining within neutrality ranges, diminishing slightly in T1. CONCLUSION. In this study, the dose of sodium bicarbonate considered in the administration protocol of 3 g /m2 Mtx, kept sodium bicarbonate levels in saliva at normal levels and pH neutral.
authors.affiliation: Research Institute, Faculty of Dentistry, University of Zulia. moralesrojas@cantv.net
authors.forename: Thais
authors.initials: T
authors.lastname: Rojas de Morales
authors.forename: Rita
authors.initials: R
authors.lastname: Navas
authors.forename: Ninoska
authors.initials: N
authors.lastname: Viera
authors.forename: Carmen Julia
authors.initials: CJ
authors.lastname: Alvarez
authors.forename: Neira
authors.initials: N
authors.lastname: Chaparro
authors.forename: Dariana
authors.initials: D
authors.lastname: Griman
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008727:Methotrexate / Q000627:therapeutic use*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism*; D017693:Sodium Bicarbonate / Q000032:analysis*
chemical_list: D000964:Antimetabolites, Antineoplastic; D017693:Sodium Bicarbonate; D008727:Methotrexate