Changes in forearm muscle temperature alter renal vascular responses to isometric handgrip.
The purpose of the present study was to examine the effect of heating and cooling the forearm muscles on renal vascular responses to ischemic isometric handgrip (IHG). It was hypothesized that heating and cooling the forearm would augment and attenuate, respectively, renal vascular responses to IHG. Renal vascular responses to IHG were studied during forearm heating at 39 degrees C (n = 15, 26 +/- 1 yr) and cooling at 26 degrees C (n = 12, 26 +/- 1 yr). For a control trial, subjects performed the experimental protocol while the forearm was normothermic (approximately 34 degrees C). Muscle temperature (measured by intramuscular probe) was controlled by changing the temperature of water cycling through a water-perfused sleeve. The experimental protocol was as follows: 3 min at baseline, 1 min of ischemia, ischemic IHG to fatigue, and 2 min of postexercise muscle ischemia. At rest, renal artery blood velocity (RBV; Doppler ultrasound) and renal vascular conductance (RVC = RBV/mean arterial blood pressure) were not different between normothermia and the two thermal conditions. During ischemic IHG, there were greater decreases in RBV and RVC in the heating trial. However, RBV and RVC were similar during postexercise muscle ischemia during heating and normothermia. RVC decreased less during cooling than in normothermia while the subjects performed the ischemic IHG protocol. During postexercise muscle ischemia, RVC was greater during cooling than in normothermia. These results indicate that heating augments mechanoreceptor-mediated renal vasoconstriction whereas cooling blunts metaboreceptor-mediated renal vasoconstriction.
Kuipers
Nathan T
NT
Heart and Vascular Institute H047, Department of Cellular and Molecular Physiology, Penn State College of Medicine, The Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033-2390, USA.
Sauder
Charity L
CL
Kearney
Matthew L
ML
Ray
Chester A
CA
D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001831:Body Temperature; D003080:Cold Temperature; D015444:Exercise; D005260:Female; D005542:Forearm; D018737:Hand Strength; D006358:Hot Temperature; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D007537:Isometric Contraction; D008297:Male; D040542:Mechanotransduction, Cellular; D018763:Muscle Fatigue; D009470:Muscle Spindles / Q000378:metabolism; D018482:Muscle, Skeletal / Q000098:blood supply / Q000294:innervation / Q000378:metabolism / Q000503:physiopathology*; D012018:Reflex; D012077:Renal Artery / Q000294:innervation / Q000503:physiopathology; D012079:Renal Circulation; D013564:Sympathetic Nervous System / Q000378:metabolism / Q000503:physiopathology*; D013997:Time Factors; D014463:Ultrasonography; D014661:Vasoconstriction