Necrosis and the serpin under't.
Caspase proteases play essential roles in apoptotic cell death, while other proteases are active in necrotic cell death. In a recent paper in Cell, Luke et al. (2007) present findings demonstrating that a gene believed to be a natural protease inhibitor may have a role in preventing necrosis.
Abraham
Mary C
MC
Laboratory of Developmental Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
Shaham
Shai
S
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins; D008247:Lysosomes / Q000378:metabolism / Q000648:ultrastructure; D009336:Necrosis; D015843:Serpins / Q000235:genetics / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; D015843:Serpins; C523762:srp-6 protein, C elegans