Lichen secondary metabolites from the cultured lichen mycobionts of Teloschistes chrysophthalmus and Ramalina celastri and their antiviral activities.
Lichens and spore-derived cultured mycobionts of Teloschistes chrysophthalmus and Ramalina celastri were studied chemically, and results indicated that they produced, respectively, parietin and usnic acid as major secondary metabolites, which were purified and identified. Identification of the compounds was performed by high performance liquid chromatography and structural elucidation by nuclear magnetic resonance (1H) and electron impact mass spectrometry. Usnic acid exhibited antiviral activity whereas parietin had a virucidal effect against the arenaviruses Junin and Tacaribe.
Fazio
Alejandra T
AT
Laboratorio de Liquenología, Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, (1428) Buenos Aires, Argentin.
Adler
Mónica T
MT
Bertoni
María D
MD
Sepúlveda
Claudia S
CS
Damonte
Elsa B
EB
Maier
Marta S
MS
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D002851:Chromatography, High Pressure Liquid; D004642:Emodin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000882:Haplorhini; D008011:Lichens / Q000737:chemistry* / Q000254:growth & development*; D013170:Spores / Q000502:physiology; D014709:Vero Cells
D000998:Antiviral Agents; D001572:Benzofurans; C073339:usnic acid; C008905:physcione; D004642:Emodin