title: New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation.
abstract: We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro.
authors.affiliation: Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. mfrohn@amgen.com
authors.forename: Mike
authors.initials: M
authors.lastname: Frohn
authors.forename: Han
authors.initials: H
authors.lastname: Xu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zou
authors.forename: Catherine
authors.initials: C
authors.lastname: Chang
authors.forename: Michele
authors.initials: M
authors.lastname: McElvaine
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Plant
authors.forename: Min
authors.initials: M
authors.lastname: Wong
authors.forename: Philip
authors.initials: P
authors.lastname: Tagari
authors.forename: Randall
authors.initials: R
authors.lastname: Hungate
authors.forename: Roland W
authors.initials: RW
authors.lastname: Bürli
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000819:agonists / Q000138:chemical synthesis / Q000494:pharmacology; D016466:CHO Cells; D002464:Cell Migration Inhibition; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D018836:Inflammation Mediators / Q000819:agonists / Q000502:physiology*; D015850:Interleukin-6 / Q000378:metabolism; D015335:Molecular Probes / Q000032:analysis* / Q000138:chemical synthesis*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D044042:Receptors, Formyl Peptide / Q000819:agonists / Q000097:blood / Q000502:physiology*; D044067:Receptors, Lipoxin / Q000819:agonists / Q000097:blood / Q000502:physiology*
chemical_list: D001562:Benzimidazoles; C105101:FPR2 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D015335:Molecular Probes; D044042:Receptors, Formyl Peptide; D044067:Receptors, Lipoxin; C014353:benzimidazolone