FTO polymorphisms in oceanic populations.
It has been suggested that Neel's "thrifty genotype" model may account for high body weights in some Oceanic populations, which presumably arose in modern times. In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity. In this study, we investigated the population frequencies of these variants in six Oceanic populations (Melanesians, Micronesians, and Polynesians) and tested for an association with BMI. Unlike European populations, the Oceanic populations displayed no significant association between the FTO polymorphisms and BMI. These variants were in strong linkage disequilibrium. The population frequencies ranged between 4.2 and 30.3% in the six Oceanic populations, and were similar to those in southeast and east Asian populations. Our study of the FTO polymorphisms has generated no evidence to support the thrifty genotype hypothesis for Oceanic populations.
Ohashi
Jun
J
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. juno-tky@umin.ac.jp.
Naka
Izumi
I
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Kimura
Ryosuke
R
Department of Forensic Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Natsuhara
Kazumi
K
School of Nursing, Fukuoka Prefectural University, Fukuoka, Japan.
Yamauchi
Taro
T
Department of Health Sciences, Hokkaido University School of Medicine, Hokkaido, Japan.
Furusawa
Takuro
T
ASNET Promotion Office, Division for International Relations, The University of Tokyo, Tokyo, Japan.
Nakazawa
Minato
M
Department of Public Health, Graduate School of Medicine, Gunma University, Gunma, Japan.
Ataka
Yuji
Y
School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan.
Patarapotikul
Jintana
J
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Nuchnoi
Pornlada
P
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Tokunaga
Katsushi
K
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Ishida
Takafumi
T
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Inaoka
Tsukasa
T
Department of Environmental Sociology, Faculty of Agriculture, Saga University, Saga, Japan.
Matsumura
Yasuhiro
Y
Information Center, National Institute of Health and Nutrition, Tokyo, Japan.
Ohtsuka
Ryutaro
R
National Institute for Environmental Studies, Ibaraki, Japan.
D000273:Adipose Tissue; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D044383:Black People / Q000235:genetics; D015992:Body Mass Index; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D009765:Obesity / Q000235:genetics*; D010139:Pacific Islands; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics
D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human