The potential role of innate immunity in the pathogenesis of Hodgkin's lymphoma.
The innate immune system is our first line of defense against danger signals but in Hodgkin's lymphoma the role seems opposite, favoring malignant development. In this article we describe interactions between Hodgkin's and Reed-Sternberg cells and the cells of the innate immune system: eosinophils, mast cells, neutrophils, and macrophages. These cells clearly contribute to the pathogenesis of this disease and to the prognosis. Cytokines and chemokines released from the activated immune cells probably promote tumor cell growth and survival along with angiogenesis. Mast cells and eosinophils seem also to contribute to the fibrosis that is so characteristic for nodular sclerosis.
Enblad
Gunilla
G
Department of Oncology, Radiology, and Clinical Immunology, Section of Oncology, Uppsala University Hospital, Rudbeck Laboratory C11, S-75185 Uppsala, Sweden. Gunilla.Enblad@onkologi.uu.se
Molin
Daniel
D
Glimelius
Ingrid
I
Fischer
Marie
M
Nilsson
Gunnar
G
D004804:Eosinophils / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology* / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D019899:Paracrine Communication; D016539:Reed-Sternberg Cells / Q000276:immunology