title: Availability of essential elements in nutrient supplements used as antidiabetic herbal formulations.
abstract: Five brands of antidiabetic herbal formulations as tablets, Diabetex, Divya Madhu Nashini, Jambrushila, Diabeticin, and Madhumeh Nashini, from different pharmacies were analyzed for six minor (Na, K, Ca, Cl, Mg, and P) and 20 trace (As, Ba, Br, Ce, Co, Cr, Cs, Cu, Fe, Hg, La, Mn, Rb, Sb, Sc, Se, Sm, Th, V, and Zn) elements by thermal neutron irradiation followed by high-resolution gamma ray spectrometry. Further Ni, Cd, and Pb were determined by atomic absorption spectrophotometry. Most elements vary in a narrow range by a factor of 2-4 while a few others vary in a wide range, e.g., Na (0.05-0.67 mg/g), Mn (26.7-250 microg/g), and V (0.26-2.50 microg/g). All the five brands contain K, Cl, Mg, P, and Ca as minor constituents along with mean trace amounts of Cr (2.11 +/- 0.67 microg/g), Cu (15.7 +/- 7.11 microg/g), Fe (459 +/- 171 microg/g), Mn (143 +/- 23 microg/g), Se (238 +/- 112 ng/g), and V (0.99 +/- 0.93 microg/g). Jambrushila is enriched in Na, Ca, Mg, Cl, Fe, Cu, Se, and Zn, essential nutrients responsible for curing diabetes. Dietary intake of Mn, Fe, and Cu are greater than 10% of the recommended dietary allowance, whereas that for Zn and Se is less than 2%. Mean contents of toxic elements (As, Cd, Hg, and Pb) were found below permissible limits except in Jambrushila. Cr and Zn were inversely correlated with r = -0.81, whereas Rb and Cs exhibit linear correlation (r = 0.93) in five brands. C, H, N analysis showed C approximately 55%, H approximately 12%, and N approximately 2% with a total of approximately 70% organic matter. However, thermal decomposition studies at 700 degrees C suggest less than 5% nonvolatile metal oxides. Herbal formulations contain minor and trace elements in bioavailable forms that favorably influence glucose tolerance and possibly increase the body's ability to ameliorate development of diabetes.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Roorkee 247 667, India.
authors.forename: R Paul
authors.initials: RP
authors.lastname: Choudhury
authors.forename: A V R
authors.initials: AV
authors.lastname: Reddy
authors.forename: A N
authors.initials: AN
authors.lastname: Garg
mesh_terms: D003920:Diabetes Mellitus / Q000178:diet therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry*; D008515:Medicine, Ayurvedic; D018977:Micronutrients / Q000032:analysis*; D009501:Neutron Activation Analysis; D010946:Plants, Medicinal / Q000737:chemistry* / Q000633:toxicity; D013054:Spectrophotometry, Atomic; D014131:Trace Elements / Q000032:analysis*
chemical_list: D007004:Hypoglycemic Agents; D018977:Micronutrients; D014131:Trace Elements