Leufolins A and B, potent butyrylcholinesterase-inhibiting flavonoid glucosides from Leucas urticifolia.
New flavonoidal glucosides leufolins A (1) and B (2), have been isolated from the ethyl acetate soluble fraction of the whole plants of Leucas urticifolia. Their structures were elucidated on the basis of extensive analysis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Both of these compounds exhibited significant inhibitory potential against the enzyme butyrylcholinesterase.
Atia-tun-Noor
International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Fatima
Itrat
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Ahmad
Ijaz
I
Malik
Abdul
A
Afza
Nighat
N
Iqbal
Lubna
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Latif
Mehreen
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Khan
Sher Bahadar
SB
D027703:Amaranthaceae / Q000737:chemistry*; D002091:Butyrylcholinesterase / Q000378:metabolism*; D002247:Carbon Isotopes; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D011522:Protons
D002247:Carbon Isotopes; D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D005960:Glucosides; D011522:Protons; C523807:leufolin A; C523808:leufolin B; D002091:Butyrylcholinesterase