Garlic (Allium sativum L.) as a potential antidote for cadmium and lead intoxication: cadmium and lead distribution and analysis in different mice organs.
Analysis and distribution of Pb and Cd in different mice organs including liver, kidney, spleen, heart and blood were evaluated after treatment with different aqueous concentrations of garlic (12.5-100 mg/l). Atomic absorption spectrometry (AAS) was used for analysis of Pb and Cd in these organs. Treatment of Cd-Pb exposed mice with garlic (12.5-100 mg/l) reduced Pb concentrations by 44.65, 42.61, 38.4, 47.56, and 66.62% in liver, kidney, heart, spleen and blood respectively. Moreover, garlic reduced Cd levels by 72.5, 87.7, 92.6, 95.6, and 71.7% in liver, kidney, heart, spleen and blood respectively. The suppressed immune responses in mice pretreated with Cd-Pb mixture were reversed by 48.85, 55.82, 81.4 and 90.7 in the presence of 100, 50, 25, and 12.5 mg/ml of garlic extract.
Massadeh
A M
AM
Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. massadeh@just.edu.jo
Al-Safi
S A
SA
Momani
I F
IF
Alomary
A A
AA
Jaradat
Q M
QM
AlKofahi
A S
AS
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002104:Cadmium / Q000493:pharmacokinetics*; D002105:Cadmium Poisoning / Q000188:drug therapy*; D005260:Female; D005737:Garlic; D007854:Lead / Q000493:pharmacokinetics*; D007855:Lead Poisoning / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D014018:Tissue Distribution / Q000187:drug effects
D010936:Plant Extracts; D002104:Cadmium; D007854:Lead