title: Toxic metals and organochlorine pesticides residue in single herbal drugs used in important ayurvedic formulation - 'Dashmoola'.
abstract: Herbal formulations are getting popularity throughout the world and commercialized extensively for various medicinal properties. WHO has emphasized the need for quality assurance of herbal products, including testing of heavy metals and pesticides residues. 'Dashmoola', a popular herbal formulation, with immunomodulator and febrifugal properties, consists of ten single root drugs. In view of WHO guidelines, single herbal drugs used in 'Dashmoola', were collected from different places of India for testing heavy metals and persistent pesticides residue. Although use of roots in 'Dashmoola' is prescribed in original ayurvedic literature but now many pharmacies use stem in place of roots. Therefore, in the present study both roots and stems were selected for estimation of six heavy metals namely arsenic (As), mercury (Hg), lead (Pb), cadmium (Cd), chromium (Cr) and nickel (Ni). Apart from these, the organochlorine pesticides residue viz. different metabolites of DDT, DDE, isomers of HCH and alpha-endosulfan were checked in total 40 samples of single crude drugs. Heavy metals except Hg, were present in most of the samples. In few samples Pb and Cd concentration were beyond the WHO permissible limits. Although alpha-HCH and gamma-HCH were present in almost all the samples, but other pesticides were not detected in these samples. DDT and DDE were found only in two samples.
authors.affiliation: Society of Ethnobotanists, National Botanical Research Institute, Lucknow 226001, India. vartikarai@rediffmail.com
authors.forename: Vartika
authors.initials: V
authors.lastname: Rai
authors.forename: Poonam
authors.initials: P
authors.lastname: Kakkar
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Singh
authors.forename: Chetna
authors.initials: C
authors.lastname: Misra
authors.forename: Santosh
authors.initials: S
authors.lastname: Kumar
authors.forename: Shanta
authors.initials: S
authors.lastname: Mehrotra
mesh_terms: D001151:Arsenic / Q000032:analysis; D006843:Hydrocarbons, Chlorinated / Q000032:analysis*; D007194:India; D008515:Medicine, Ayurvedic; D008628:Mercury / Q000032:analysis; D019216:Metals, Heavy / Q000032:analysis*; D010573:Pesticide Residues / Q000032:analysis; D028321:Plant Preparations / Q000032:analysis* / Q000592:standards; D018517:Plant Roots / Q000737:chemistry; D011786:Quality Control
chemical_list: C532420:Dashmoola; D006843:Hydrocarbons, Chlorinated; D019216:Metals, Heavy; D010573:Pesticide Residues; D028321:Plant Preparations; D008628:Mercury; D001151:Arsenic