title: [Successful administration of nifekalant hydrochloride for postoperative junctional ectopic tachycardia in congenital cardiac surgery].
abstract: Two episode of junctional ectopic tachycardia (JET) caused hemodynamic deterioration early after tetralogy of Fallot repair in an 8-month-old infant. Sinus rhythm resumed in each of the episodes immediately after intravenous administration of nifekalant hydrochloride (NIF), a newly developed Vaughan-Williams class III antiarrhythmic drug in Japan. Although QT interval was modestly prolonged with NIF, no life-threatening ventricular arrhythmia (i.e., torsades de pointes) occurred. NIF might be an effective alternative in the treatment of postoperative JET in congenital cardiac surgery.
authors.affiliation: Department of Cardiovascular Surgery, Osaka Medical College, Takatsuki, Japan.
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Nemoto
authors.forename: H
authors.initials: H
authors.lastname: Ozawa
authors.forename: T
authors.initials: T
authors.lastname: Katsumata
authors.forename: N
authors.initials: N
authors.lastname: Ozaki
authors.forename: K
authors.initials: K
authors.lastname: Okumura
authors.forename: H
authors.initials: H
authors.lastname: Katayama
authors.forename: H
authors.initials: H
authors.lastname: Tamai
authors.forename: H
authors.initials: H
authors.lastname: Kishida
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy*; D011744:Pyrimidinones / Q000627:therapeutic use*; D013613:Tachycardia, Ectopic Junctional / Q000188:drug therapy* / Q000209:etiology; D013771:Tetralogy of Fallot / Q000601:surgery*
chemical_list: D000889:Anti-Arrhythmia Agents; D011744:Pyrimidinones; C076259:nifekalant