title: Can probability of genetic mutation be an indicator of clinical relevance?
abstract: NPM1 gene mutation evaluated on a population basis is a valuable and realistic tool to reflect the pathophysiological relevance of cancer. In a comparison of the NPM1 cDNA of human bladder cancer with its consensus sequence, we have found that a higher NPM1 sequence identity in a population is consistent with poor tumor differentiation, advanced tumor stage, and likelihood of recurrence. These data imply that "probability" of NPM1 mutation is an indicator of status of malignancy.
authors.affiliation: Department of Urology, Chang Gung Memorial Hospital, Chang Gung Bioinformatics Center, Kwei-Shan, Tao-Yuan 333, Taiwan, ROC.
authors.forename: Chien-Lun
authors.initials: CL
authors.lastname: Chen
authors.forename: Ke-Hung
authors.initials: KH
authors.lastname: Tsui
authors.forename: Chiao-Yun
authors.initials: CY
authors.lastname: Lin
authors.forename: Phei-Lang
authors.initials: PL
authors.lastname: Chang
authors.forename: Petrus
authors.initials: P
authors.lastname: Tang
authors.forename: Benjamin  Yat-Ming
authors.initials: B
authors.lastname: Yung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000473:pathology; D017931:DNA Primers / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000235:genetics*; D000090243:Nucleophosmin; D011336:Probability; D012008:Recurrence; D012689:Sequence Homology, Nucleic Acid; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D017931:DNA Primers; D018076:DNA, Complementary; D004273:DNA, Neoplasm; C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D000090243:Nucleophosmin