Sarcoidosis in patients with celiac disease.
OBJECTIVE
Several case reports and European studies have suggested an association between sarcoidosis and celiac disease; however, they have been inconsistent. We therefore analyzed a large cohort of celiac-disease patients to assess this association.


METHODS
An anonymized database of patients with celiac disease was reviewed to determine the number of patients with sarcoidosis. Age- and gender-adjusted standardized morbidity ratios with corresponding 95% confidence intervals (CI) were calculated by comparing results to US-population-derived prevalence data.


RESULTS
Ten patients were found to have a comorbid diagnosis of sarcoidosis, representing an age- and gender-adjusted standardized morbidity ratio of 36.8 (95% CI 26.7-50.9).


CONCLUSIONS
In this cohort of patients with celiac disease, there was a significantly increased risk of sarcoidosis when compared with the American white population. This further strengthens prior associations that have been made suggesting a shared mechanism behind the etiologies of celiac disease and sarcoidosis.
Hwang
Elizabeth
E
Department of Medicine, Columbia University Medical Center, 180 Fort Washington Avenue, Room 956, New York, NY 10032, USA.
McBride
Russell
R
Neugut
Alfred I
AI
Green
Peter H R
PH
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002446:Celiac Disease / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000453:epidemiology* / Q000473:pathology; D017678:Sex Distribution; D044465:White People / Q000706:statistics & numerical data*