A case of celiac disease mimicking amyotrophic lateral sclerosis.
BACKGROUND
A 44-year-old male presented to a general neurology clinic with a 6-month history of progressive right-sided spastic hemiparesis without sensory symptoms or signs. The thigh muscle in the affected leg showed signs of wasting. The patient had a remote family history of celiac disease.


METHODS
Neurological examination, neurophysiological studies, brain MRI scan, routine blood tests, duodenal biopsy, cerebrospinal fluid analysis including polymerase chain reaction test for JC virus DNA, serological testing for HIV and for the presence of serum antibodies to endomysium, gliadin and tissue transglutaminase.


METHODS
Celiac disease with neurological involvement, mimicking amyotrophic lateral sclerosis.


RESULTS
Strict gluten-free diet.
Turner
Martin R
MR
Department of Neurology, John Radcliffe Hospital, Oxford, UK.
Chohan
Gurjit
G
Quaghebeur
Gerardine
G
Greenhall
Richard C D
RC
Hadjivassiliou
Marios
M
Talbot
Kevin
K
D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis*; D001921:Brain / Q000473:pathology; D002446:Celiac Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000178:diet therapy; D018753:Diet, Protein-Restricted; D005983:Glutens; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination / Q000379:methods; D012680:Sensitivity and Specificity; D012698:Serologic Tests
D005983:Glutens