Elemental tomography of cancer-cell spheroids reveals incomplete uptake of both platinum(II) and platinum(IV) complexes.
Alderden
Rebecca A
RA
Centre for Heavy Metals Research, School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Mellor
Howard R
HR
Modok
Szabolcs
S
Hall
Matthew D
MD
Sutton
Stephen R
SR
Newville
Matthew G
MG
Callaghan
Richard
R
Hambley
Trevor W
TW
D045744:Cell Line, Tumor; D002945:Cisplatin / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D008856:Microscopy, Fluorescence; D009942:Organometallic Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D010984:Platinum / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013052:Spectrometry, X-Ray Emission / Q000295:instrumentation / Q000379:methods*; D018874:Spheroids, Cellular / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*
D009942:Organometallic Compounds; D010984:Platinum; D002945:Cisplatin