Oncogenic role of nucleophosmin/B23.
Nucleophosmin/B23 was first identified as a nucleolar protein expressed at higher levels in cancer cells compared to normal cells. Nucleophosmin/B23 has long been thus thought to have a role in tumor formation. With our efforts and others in the last 15 years, nucleophosmin/B23 has proven to have an oncogenic role. In this review, we provide evidence suggesting that nucleophosmin/B23 may be a crucial gene in regulation of cancer growth and discuss how nucleophosmin/B23 can contribute to tumorigenesis.
Yung
Benjamin Yat Ming
BY
Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan, Taiwan. byung@mail.cgu.edu.tw
D000818:Animals; D050687:E2F1 Transcription Factor / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D000090243:Nucleophosmin; D011499:Protein Processing, Post-Translational; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D050687:E2F1 Transcription Factor; C493753:E2F1 protein, human; C489427:MYC protein, human; C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D016271:Proto-Oncogene Proteins c-myc; D016159:Tumor Suppressor Protein p53; D000090243:Nucleophosmin