Consumption of silibinin, a flavonolignan from milk thistle, and mammary cancer development in the C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma (TAg) mouse.
Silibinin is a flavonolignan extracted from milk thistle with cancer chemopreventive activity in preclinical models of prostate and colorectal cancer. A milk thistle extract, of which silibin is a major component, has recently been shown to exacerbate mammary carcinogenesis in two rodent models. We tested the hypothesis that consumption of silibinin or silipide, a silibinin formulation with pharmaceutical properties superior to the unformulated agent, affect breast cancer development in the C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma mouse model. Mice received silibinin or silipide (0.2% silibinin equivalents) with their diet from weaning, and tumour development was monitored by weekly palpation and the number and weight of neoplasms at the end of the experiment. Intervention neither promoted, nor interfered with, tumour development. The result suggests that promotion of carcinogenesis is not a feature of silibinin consistent across rodent models of mammary carcinogenesis.
Verschoyle
Richard D
RD
Cancer Biomarkers and Prevention Group, Department of Cancer Studies, RKCSB, LRI, University of Leicester, Leicester, LE2 7LX, UK.
Brown
Karen
K
Steward
William P
WP
Gescher
Andreas J
AJ
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics*; D005260:Female; D044947:Flavonolignans / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D015674:Mammary Neoplasms, Animal / Q000139:chemically induced* / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D020944:Silybum marianum / Q000737:chemistry*; D015394:Molecular Structure; D010713:Phosphatidylcholines / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000077385:Silybin; D012838:Silymarin / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D013237:Stereoisomerism
D000952:Antigens, Polyomavirus Transforming; D044947:Flavonolignans; D010713:Phosphatidylcholines; D012838:Silymarin; C067772:IdB 1016; D000077385:Silybin