title: New light on an old story: facile and efficient synthesis of 1,3-diaryl-5-spirohexahydropyrimidines via a six-molecule, three-component mannich-type reaction.
abstract: A facile and efficient synthesis of 1,3-diaryl-5-spirohexahydropyrimidines via a one-pot condensation of anilines, formaldehyde, and cyclohexanones is reported. In this one-pot, three-component reaction, six molecules of reactants are involved and six new covalent bonds are generated. Bicyclic products are obtained from the starting materials in one pot using readily available starting materials and catalysts.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Wei
authors.forename: Ze-Yi
authors.initials: ZY
authors.lastname: Yan
authors.forename: Yan-Ning
authors.initials: YN
authors.lastname: Niu
authors.forename: Gao-Qiang
authors.initials: GQ
authors.lastname: Li
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D018360:Crystallography, X-Ray; D003512:Cyclohexanones / Q000737:chemistry*; D005557:Formaldehyde / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003512:Cyclohexanones; D011725:Pyridines; D011743:Pyrimidines; D005557:Formaldehyde