title: Antimutagenic and antiproliferative effects of roasted and defatted peanut dregs on human leukemic U937 and HL-60 cells.
abstract: The antimutagenic effects on Salmonella typhimurium TA98 and TA100 strains and antiproliferative effects on leukemia cell lines (U937 and HL-60) of peanut protein isolate (PPI), peanut protein isolate enzyme hydrolysate (PPIEH), roasted and defatted peanut dregs (RDPD), and roasted and defatted peanut dregs enzyme hydrolysate (RDPDEH) were investigated. The antimutagenic effects on B(a)P and 4-NQO toward the TA98 and TA100 strains were found to follow a diminishing order: RDPD > RDPDEH >> PPI = PPIEH with dose-dependency. Antiproliferative effects on leukemia cells U937 and HL-60 were also detected. RDPD was found to be the most effective of all the peanut preparations. At 100 microg/mL concentration, RDPD inhibited the proliferation of U937 and HL-60 cells by 56% and 52%, respectively. We propose to consider RDPD and RDPDEH in the development of natural chemotherapeutic or chemopreventive dietary supplements against leukemia and to upgrade the utilization of these by-products in peanut oil production.
authors.affiliation: Department of Food Science and Technology, Chung-Hwa University of Medical Technology, Tainan 700, Taiwan.
authors.forename: Jean-Yu
authors.initials: JY
authors.lastname: Hwang
authors.forename: Yuh Tai
authors.initials: YT
authors.lastname: Wang
authors.forename: Yung-Shin
authors.initials: YS
authors.lastname: Shyu
authors.forename: James Swi-Bea
authors.initials: JS
authors.lastname: Wu
mesh_terms: D016587:Antimutagenic Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D010367:Arachis / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D018922:HL-60 Cells / Q000187:drug effects; D006358:Hot Temperature; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects*; D020298:U937 Cells / Q000187:drug effects
chemical_list: D016587:Antimutagenic Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts