title: Ubiquitin-mediated proteasomal degradation in normal and malignant hematopoiesis.
abstract: Understanding the molecular mechanisms controlling normal hematopoietic differentiation is critical to develop new treatments for blood diseases and to manipulate stem cells. Despite the identification of many players in hematopoiesis, the molecular mechanisms controlling hematopoietic differentiation remain poorly understood. Due to a number of recent findings, the targeting of regulators of hematopoiesis to proteasomal degradation might be an important step in control of this developmental program.
authors.affiliation: Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS, Université Paul Sabatier, 205 Route de Narbonne, F-31077 Toulouse, France.
authors.forename: Mélina L
authors.initials: ML
authors.lastname: Heuzé
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lamsoul
authors.forename: Christel
authors.initials: C
authors.lastname: Moog-Lutz
authors.forename: Pierre G
authors.initials: PG
authors.lastname: Lutz
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D019337:Hematologic Neoplasms / Q000378:metabolism*; D006410:Hematopoiesis; D006413:Hematopoietic System / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D054829:RING Finger Domains / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; C480733:SOSTDC1 protein, human; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes; C473697:UBE4B protein, human; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex