[Study of intracerebral focus changes on CADASIL by using MR imaging].
OBJECTIVE
To investigate dynamic changes of intracerebral focus on cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).


METHODS
Using the modified Scheltens scale, the magnetic resonance (MR) changes of lesion distribution, size and shape in 7 patients from a CADASIL family were retrospectively analyzed during 3 years observed.


RESULTS
In 6 of 7 patients, the number and volume of lesion areas in the white matter were increased (parietal lobe, n = 6; temporal lobe, n = 5; frontal lobe, n = 3; occipital lobe, n = 2) and some areas even became confluent as a mass or chain. New lacunar infarcts (n = 1 - 5) appeared in 5 patients and the arcuate fiber were involved in 1 patients. Slight enlargement could be seen in lateral ventricle (n = 1) or lateral ventricle with third ventricle (n = 1).


CONCLUSIONS
MR imaging can help us to reveal dynamic changes of brain lesions and prognosis in patients with CADASIL.
Li
Jian-ce
JC
Department of Radiology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
Jin
De-xin
DX
Yang
Yun-jun
YJ
Chen
Xiu-yun
XY
Li
Jin-lin
JL
Wang
Mei-hao
MH
Wu
En-fu
EF
D000328:Adult; D001921:Brain / Q000473:pathology; D020520:Brain Infarction / Q000473:pathology; D046589:CADASIL / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies