Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii.
From the petroleum ether extract of the root bark of Cussonia zimmermannii four polyacetylenes, 1- 4, were isolated, three of which ( 1- 3) were active against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Plasmodium falciparum, and Leishmania donovani.
Senn
Martin
M
Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.
Gunzenhauser
Sigmund
S
Brun
Reto
R
Séquin
Urs
U
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027481:Araliaceae / Q000737:chemistry*; D007893:Leishmania donovani / Q000187:drug effects; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013636:Tanzania; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects
D000981:Antiprotozoal Agents; D053279:Polyynes