title: Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones.
abstract: A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discovered either in the anti-proliferation test or in the HIV anti-integrase test.
authors.affiliation: Laboratoire de Chimie Organique et Macromoléculaire, UMR CNRS 8009, Bâtiment C3, Université de Lille 1, 59655 Villeneuve d'Ascq Cedex, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bailly
authors.forename: Clémence
authors.initials: C
authors.lastname: Queffélec
authors.forename: Gladys
authors.initials: G
authors.lastname: Mbemba
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mouscadet
authors.forename: Nicole
authors.initials: N
authors.lastname: Pommery
authors.forename: Jean
authors.initials: J
authors.lastname: Pommery
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Hénichart
authors.forename: Philippe
authors.initials: P
authors.lastname: Cotelle
mesh_terms: D001483:Base Sequence; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D017931:DNA Primers; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology*; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
chemical_list: D017931:DNA Primers; D005663:Furans; D019428:HIV Integrase Inhibitors