Evolution of cd59 gene in mammals.
The CD59-coding sequences were obtained from 5 mammals by PCR and BLAST, and combined with the available sequences in GenBank, the nucleotide substitution rates of mammalian cd59 were calculated. Results of synonymous and nonsynonymous substitution rates revealed that cd59 experienced negative selection in mammals overall. Four sites experiencing positive selection were found by using "site-specific" model in PAML software. These sites were distributed on the molecular surface, of which 2 sites located in the key functional domain. Furthermore, "branch-site-specific" model detected 1 positive site in cd59a and cd59b lineages which underwent accelerated evolution caused by positive selection after gene duplication in mouse.
Gong
YuanYing
Y
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
Peng
MinSheng
M
Zhou
WeiPing
W
Zhang
YaPing
Y
D000818:Animals; D018957:CD59 Antigens / Q000235:genetics*; D002417:Cattle; D002522:Chlorocebus aethiops; D016673:Colobinae; D004285:Dogs; D019143:Evolution, Molecular; D020440:Gene Duplication; D006801:Humans; D006922:Hylobates; D008253:Macaca mulatta; D051379:Mice; D002679:Pan troglodytes; D011817:Rabbits; D051381:Rats; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA
D018957:CD59 Antigens