Effects of a cell adhesion molecule coating on the blasted surface of titanium implants on bone healing in the rabbit femur.
OBJECTIVE
One strategy to improve implant osseointegration is to control the quality of the bone reaction at the implant-bone tissue interface using an implant coated with biologically active substances. The purpose of this study was to investigate the effect of a tetra-cell adhesion molecule (T-CAM) coating composed of 4 cell-adhesion molecules-an arginine-glycine-aspartic acid (RGD) sequence, a proline-histidine-serine-arginine-asparagine (PHSRN) sequence, a tyrosine-histidine sequence (YH), and a glutamic acid-proline-aspartic acid-isoleucine-methionine (EPDIM)-on the rough-surfaced titanium implant on peri-implant bone formation in the rabbit femur with poor local bone conditions and minimal primary stability.


METHODS
Seven T-CAM-coated (blasted/T-CAM) and uncoated (blasted) implants with a rough surface (hydroxyapatite-blasted; Ra = 1.8 microm) were placed in slightly oversized beds of the metaphyses of the right and left femurs of 7 New Zealand White rabbits with light tactile pressure, and minimal primary stability was obtained. To evaluate the effects of T-CAM coating on the peri-implant bone healing response, histomorphometric analysis was performed 8 weeks after surgery. The 2 groups were compared using the Student t test, with a significance level of P < .05.


RESULTS
Compared to uncoated blasted implants at 8 weeks of healing, the blasted/T-CAM implants showed a significantly greater amount of bone-implant contact (BIC; P < .01) and new bone formation in the zones 0 to 100 microm and 0 to 500 microm lateral to the implant surface (P < .05) in the medullary space.


CONCLUSIONS
The T-CAM coating on the rough-surfaced titanium implants significantly enhanced peri-implant bone formation in rabbit femurs with poor local bone condition.
Park
Jin-Woo
JW
Department of Periodontology, College of Dentistry, Kyungpook National University, Daegu, Korea.
Lee
Sang-Gu
SG
Choi
Byung-Ju
BJ
Suh
Jo-Young
JY
D000818:Animals; D015519:Bone Density / Q000502:physiology; D001853:Bone Marrow / Q000473:pathology; D002113:Calcification, Physiologic / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry; D005269:Femur / Q000473:pathology*; D008297:Male; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology*; D011817:Rabbits; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D014945:Wound Healing / Q000502:physiology
D015815:Cell Adhesion Molecules; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D003764:Dental Materials; D017886:Durapatite; D014025:Titanium