title: Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms.
abstract: MTHFR gene variants C677T and A1298C seem to be related to an increased risk of migraine. Folates' metabolism could play a role in the pathophysiology of migraine. We supplemented 16 children with migraine, hyperhomocysteinemia, and MTHFR polymorphisms with folic acid and obtained a resolution/reduction of migraine attacks. Although the mechanism leading to these effects has been not made clear, we believe that the use of folic acid needs further investigations in migraineurs with hyperhomocysteinemia and MTHFR variants. A randomized, double-blind, placebo controlled crossover trial is needed to support these findings.
authors.affiliation: Department of Medical and Surgical Pediatrics, Unit of Infantile Neuropsychiatry, University Hospital of Messina, Messina, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Di Rosa
authors.forename: Sarina
authors.initials: S
authors.lastname: Attinà
authors.forename: Maria
authors.initials: M
authors.lastname: Spanò
authors.forename: Giulia
authors.initials: G
authors.lastname: Ingegneri
authors.forename: Domenica L
authors.initials: DL
authors.lastname: Sgrò
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Pustorino
authors.forename: Maria
authors.initials: M
authors.lastname: Bonsignore
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Trapani-Lombardo
authors.forename: Gaetano
authors.initials: G
authors.lastname: Tortorella
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008881:Migraine Disorders / Q000150:complications* / Q000188:drug therapy / Q000235:genetics*; D011110:Polymorphism, Genetic; D016896:Treatment Outcome
chemical_list: D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2)