title: Cost of varicella-related hospitalisations in an Italian paediatric hospital: comparison with possible vaccination expenses.
abstract: OBJECTIVE
  The aims of the study were to evaluate the economic burden of hospitalisations due to varicella in an Italian paediatric hospital during a 1-year period and to compare the data with potential expenses projected for a varicella mass vaccination programme.
  
  
  METHODS
  An observational, retrospective, cohort study was designed to measure hospital admission costs in a cohort of paediatric patients with varicella in a 12-month period. A cost comparison with a vaccination programme planned to prevent varicella in a whole birth cohort was performed. All children 0-16 years referred to the Anna Meyer Children's Hospital (AMCH) were considered. Since AMCH is a tertiary-level hospital and accept patients from other Italian regions, in order to avoid overestimation of hospitalisation expenses, all analyses pertaining to both vaccination and hospitalisation costs were uniquely calculated on the basis of the cohort of residents in the district of Florence.
  
  
  RESULTS
  A total of 279 children were examined in the emergency department for varicella; 47/279 (16.8%) were sent to the inpatient clinic. The highest rate of hospitalisation (85.1%) was found in children < 4 years of age, and the largest number of complications (87.2%) occurred in previously healthy children. Mean length of hospitalisation (5.7 +/- 0.6 days) was similar to that reported in other western countries.
  
  
  CONCLUSIONS
  Excluding any indirect cost, permanent sequelae and serious outcomes such as death, hospital expenses (corresponding to euro239 654 in a 1-year period), would account for around 80% of total expenses for vaccinating an entire birth cohort (euro310353).
authors.affiliation: Paediatric Immunology Unit, Anna Meyer Children's Hospital and University of Florence, Florence, Italy. chiara.azzari@unifi.it
authors.forename: C
authors.initials: C
authors.lastname: Azzari
authors.forename: C
authors.initials: C
authors.lastname: Massai
authors.forename: C
authors.initials: C
authors.lastname: Poggiolesi
authors.forename: G
authors.initials: G
authors.lastname: Indolfi
authors.forename: G
authors.initials: G
authors.lastname: Spagnolo
authors.forename: M
authors.initials: M
authors.lastname: De Luca
authors.forename: P
authors.initials: P
authors.lastname: Gervaso
authors.forename: M
authors.initials: M
authors.lastname: de Martino
authors.forename: M
authors.initials: M
authors.lastname: Resti
mesh_terms: D000293:Adolescent; D002644:Chickenpox / Q000191:economics* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003365:Costs and Cost Analysis; D016527:Drug Costs; D005260:Female; D017721:Hospital Costs; D006760:Hospitalization / Q000191:economics*; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007558:Italy; D007902:Length of Stay / Q000191:economics; D008297:Male; D014611:Vaccination / Q000191:economics*