title: Synthesis of (+)-vinblastine and its analogues.
abstract: A synthetic route to vinblastine and its analogues with an ethynyl group, which features a stereoselective coupling of an 11-membered key intermediate with vindoline, is described. Transformations of the alkynyl moiety including a partial reduction as well as a Sonogashira coupling furnished a variety of analogues.
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yokoshima
authors.forename: Siro
authors.initials: S
authors.lastname: Simizu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Tokuyama
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
chemical_list: D014747:Vinblastine