Screening of hepatoprotective effect of a herbal mixture against CCl4 induced hepatotoxicity in Swiss albino mice.
The hepatoprotective potential of a herbal mixture was evaluated against CCl4 induced liver injury in Swiss albino mice. Liv 52, a commercially available polyherbal hepatoprotective drug was evaluated for comparison. The potential toxicity of the above herbal hepatoprotective agents was also compared. It was observed that there was a reduction in the enzyme biomarkers (Aspartate and Alanine Transaminase) of liver injury in the herbal mixture treated groups, which was similar to the reduction initiated by Liv 52. An increase in glutathione was observed in the herbal mixture treated groups and it was assumed that the herbal mixture protects the liver by virtue of its antioxidant nature along with high regeneration initiation potential. From the study it is also concluded that the herbal mixture is safer than Liv 52.
Lal
A Arun Sam
AA
R.C.C. Laboratories India Pvt. Ltd., Genome Valley, Shameerpet, Hyderabad 500 078, India. arthur.arun@rccltd.in
Murthy
P Balakrishna
PB
Pillai
K Sadasivan
KS
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001806:Blood Urea Nitrogen; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D003404:Creatinine / Q000097:blood; D004338:Drug Combinations; D005260:Female; D005978:Glutathione / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D019684:Magnoliopsida / Q000737:chemistry / Q000633:toxicity; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use* / Q000633:toxicity; D010946:Plants, Medicinal / Q000633:toxicity; D020011:Protective Agents / Q000627:therapeutic use* / Q000633:toxicity; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D001786:Blood Glucose; D004338:Drug Combinations; D010936:Plant Extracts; D020011:Protective Agents; C002614:Liv 52; D003404:Creatinine; D002251:Carbon Tetrachloride; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005978:Glutathione