title: The evaluation and management of patients with first-episode schizophrenia: a selective, clinical review of diagnosis, treatment, and prognosis.
abstract: Patients who present with a first episode of psychosis pose many challenges to psychiatry. While some morbidity from schizophrenia is probably not modifiable once acute psychosis has occurred, the best management of this stage of illness nevertheless holds the promise of improving long-term outcomes. We review the clinical literature on first-episode psychosis to derive clinical guidance with regard to timely diagnosis and optimal pharmacological and nonpharmacological treatment. We describe the illness course and the prognosis for this acute phase of illness and the immediate, postpsychotic period.
authors.affiliation: The Department of Psychiatry, Harvard Medical School, Schizophrenia Program, Massachusetts General Hospital, Boston, MA 02114, USA. ofreudenreich@partners.org
authors.forename: Oliver
authors.initials: O
authors.lastname: Freudenreich
authors.forename: Daphne J
authors.initials: DJ
authors.lastname: Holt
authors.forename: Corinne
authors.initials: C
authors.lastname: Cather
authors.forename: Donald C
authors.initials: DC
authors.lastname: Goff
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D019411:Clinical Laboratory Techniques; D015897:Comorbidity; D003937:Diagnosis, Differential; D004569:Electroencephalography; D006801:Humans; D011379:Prognosis; D012008:Recurrence; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy*
chemical_list: D014150:Antipsychotic Agents