title: Human homeostasis in high-latitude environment.
abstract: Profound changes occur in human metabolism in high-latitude environments under the action of climatic, industrial, and social factors. These changes involve protein, fat, carbohydrate, vitamin, and macro and microelement metabolism. This allowed us to state that "a polar metabolic type" is formed in the Arctic and Antarctic regions. The most pronounced alterations are found in energy metabolism. They can be characterized as "the change-over from carbohydrate-type metabolism to the lipid one." Metabolic changes are reflected in the chemical composition of internal medium (blood) of the human organism and its homeostasis. However, homeostasis in high-latitude environments depends not only on natural, but also on various conditioning factors, in particular, prolonged emotional stress and inactual nutritional pattern. These two factors exert a pronounced effect on adaptive changes in human metabolism and its homeostasis. Both factors often act concurrently and result in sustained and persistent changes of homeostasis, which lead directly to obesity and development of endocrine and cardiovascular pathology. This is observed not only for newcomers, but also for the indigenous population of the Asian North.
authors.affiliation: Institute of Biochemistry SB RAMS, Russia. ibch@soramn.ru
authors.forename: L E
authors.initials: LE
authors.lastname: Panin
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D001110:Arctic Regions; D004644:Emotions; D004734:Energy Metabolism / Q000502:physiology*; D004777:Environment; D004782:Environmental Health; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D008660:Metabolism / Q000502:physiology; D009752:Nutritional Status; D010865:Pilot Projects; D044382:Population Groups; D013315:Stress, Psychological; D022722:Thermogenesis