Mcp-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in hepatopulmonary syndrome.
OBJECTIVE
The aim of this case-control study was to investigate both the distribution of MCP-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes.


METHODS
Between September 1997-January 2005, 20 patients with HPS (group 1) were compared with a group of cirrhotic patients (group 2, n = 19) as well as unrelated healthy controls (group 3, n = 59) in respect to MCP1, eNOS, tPA and PAI-1 gene polymorphism frequency distribution.


RESULTS
MCP1-2518G allele carriage in patients with HPS was higher than in controls (P = 0.01). In non-HPS cirrhotic patients, eNOS Glu298Asp, Asp gene carriers and frequency of Asp alleles were detected to be considerably higher than in patients with HPS and healthy controls (P < 0.05).


CONCLUSIONS
HPS is more common in patients with MCP-1 2518G gene carriage; conversely it is less frequent in patients with high frequency of eNOS 298Asp allele and eNOS 298Asp carriage.
Tumgor
Gokhan
G
Department of Pediatric Gastroenterology, Hepatology and Nutrition and Organ Transplantation and Research Center, Ege University School of Medicine, Izmir, Turkey. gtumgor74@yahoo.com
Berdeli
Afig
A
Arikan
Cigdem
C
Levent
Ertürk
E
Aydogdu
Sema
S
D000293:Adolescent; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D020065:Hepatopulmonary Syndrome / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D010641:Phenotype; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D010959:Tissue Plasminogen Activator / Q000235:genetics*
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D017395:Plasminogen Activator Inhibitor 1; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; D010959:Tissue Plasminogen Activator