title: Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived Fungus Aspergillus candidus IF10.
abstract: Three novel cytotoxic substances named prenylterphenyllin (1), 4''-deoxyprenylterphenyllin (2), and 4''-deoxyisoterprenin (3) were isolated from a cultured marine-derived fungus of Aspergillus candidus IF10 together with 4''-deoxyterprenin (4). Their chemical structures were elucidated on the basis of 2D NMR analysis. These compounds 1 approximately 4 showed cytotoxic activity against human epidermoid carcinoma KB cells (KB3-1) with IC(50) of 8.5, 3.0, 2.5, and 4.5 microg/ml, respectively.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, Japan.
authors.forename: Hong
authors.initials: H
authors.lastname: Wei
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Inada
authors.forename: Asami
authors.initials: A
authors.lastname: Hayashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Higashimoto
authors.forename: Patamaporn
authors.initials: P
authors.lastname: Pruksakorn
authors.forename: Sayo
authors.initials: S
authors.lastname: Kamada
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Arai
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ishida
authors.forename: Motomasa
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D013730:Terphenyl Compounds / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C525274:4''-deoxyisoterprenin; C525273:4''-deoxyprenylterphenyllin; C112886:4''-deoxyterprenin; D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D013730:Terphenyl Compounds; C525272:prenylterphenyllin