title: Evaluation of the efficacy and safety of a novel formulation of metaflumizone plus amitraz in dogs naturally infested with fleas and ticks in Europe.
abstract: The efficacy and safety of a novel spot-on formulation of metaflumizone plus amitraz (ProMeris/ProMeris Duo for Dogs, Fort Dodge Animal Health, Overland Park, KS) was assessed in dogs naturally infested with ticks and/or fleas in a multiregional, clinical field study. Nineteen veterinary clinics in Germany and 11 clinics in France enrolled patients to the study. One hundred eighty one dogs with tick infestation and 170 dogs with flea infestation (plus three dogs harboring both ticks and fleas) qualified as primary patients and were randomly allocated to one of two treatments in a ratio of approximately 2:1 for metaflumizone plus amitraz (minimum dosage of 20 plus 20mg/kg) or fipronil (at the recommended label rate). Clinical examinations and baseline parasite counts were performed on Day 0 prior to treatment. Tick and/or flea counts and safety evaluations were repeated at intervals of about 2 weeks for 8 weeks. Both products resulted in consistent reductions in tick numbers (>81%) throughout the study, with metaflumizone plus amitraz giving consistently higher reductions in tick numbers. The efficacy against tick count compared with Day 0 was 97.6%, 93.5%, 89% and 94% at Day 14, 28, 42 and 56, respectively, for metaflumizone plus amitraz. The corresponding efficacies for fipronil were 86.3%, 81.1%, 84.8% and 86.1%. Within groups, the tick reduction was highly significant (P<0.0001) compared to baseline at all observation periods. Both treatments resulted in consistent (>89%) and highly significant (P<0.0001) reductions in flea numbers relative to the baseline counts throughout the study, although fipronil resulted in numerically higher reductions on each count day. The efficacy against fleas compared to baseline was 91.8%, 88.7%, 91.5% and 92.0% at Day 14, 28, 42 and 56, respectively, for metaflumizone plus amitraz. The corresponding efficacies for fipronil were 98.2%, 96.3%, 95.9% and 96.7%. Metaflumizone plus amitraz was highly effective in controlling existing infestations of fleas and ticks on dogs and was effective against reinfestation for at least 56 days. Metaflumizone plus amitraz showed a good tolerance profile in dogs.
authors.affiliation: KLIFOVET AG, Geyerspergerstr. 27, D-80689 Munich, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Hellmann
authors.forename: K
authors.initials: K
authors.lastname: Adler
authors.forename: L
authors.initials: L
authors.lastname: Parker
authors.forename: K
authors.initials: K
authors.lastname: Pfister
authors.forename: R L
authors.initials: RL
authors.lastname: Delay
authors.forename: D
authors.initials: D
authors.lastname: Rugg
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004338:Drug Combinations; D064420:Drug-Related Side Effects and Adverse Reactions; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000662:veterinary*; D005060:Europe; D005260:Female; D007306:Insecticides / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D008297:Male; D011720:Pyrazoles / Q000627:therapeutic use; D011897:Random Allocation; D012664:Semicarbazones / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D013984:Tick Infestations / Q000188:drug therapy / Q000662:veterinary; D014052:Toluidines / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D014867:Water
chemical_list: D004338:Drug Combinations; D007306:Insecticides; D011720:Pyrazoles; D012664:Semicarbazones; D014052:Toluidines; D014867:Water; C014983:amitraz; C528570:metaflumizone; C082360:fipronil