[Microsatellite DNA polymorphism of adrenomedullin gene and atherosclerotic cerebral infarction].
OBJECTIVE
To detect the correlation between the microsatellite DNA polymorphism of adrenomedullin(ADM) gene (repeated sequences of CA) and the atherosclerotic cerebral infarction (ACI).


METHODS
With PCR, ADM genotype was monitored from 189 normotensive subjects and 283 cerebral infarction patients. By using radioimmunoassay, their plasma ADM concentration was measured, so as the biochemical index.


RESULTS
The genotype distribution of ADM between the health control and ACI groups was significantly different, chi square was 28.732, P < 0.05. As one of the four alleles, including 11, 13, 14 and 19 alleles, the frequency of 19 allele in ACI groups was much higher than that in the health control group, chi square was 26.929, P < 0.05. However, there was no significant difference in plasma ADM concentration among the different genotypes of the ACI patients.


CONCLUSIONS
Microsatellite DNA polymorphism of ADM gene may be associated with the genetic predisposition to ACI.
Bi
Guo-rong
GR
Department of Neurology, the Second Affiliated Hospital, China Medical University, Shenyang, Liaoning, 110004 PR China. biguorongcmu@sina.com
Hai
Hong
H
Bai
Li-juan
LJ
Zhang
He-min
HM
Zhou
Hui-jie
HJ
D053607:Adrenomedullin / Q000235:genetics*; D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic
D053607:Adrenomedullin