A beta-mannoside-selective pyrrolic tripodal receptor.
Acetalic substituents strategically located in a pyrrolic tripodal structure provide a new synthetic receptor endowed with unprecedented affinity for mannosides and the highest selectivity for beta-mannose ever reported for synthetic H-bonding receptors. Binding properties have been determined by NMR, ITC, and ESI-MS techniques, while affinities have been univocally assessed by the BC50(0) parameter, a general descriptor of binding affinity.
Nativi
Cristina
C
Dipartimento di Chimica Organica, Centro Risonanze Magnetiche, Università di Firenze, Sesto Fiorentino, Florence, Italy.
Cacciarini
Martina
M
Francesconi
Oscar
O
Moneti
Gloriano
G
Roelens
Stefano
S
D008362:Mannosides / Q000737:chemistry*; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry
D008362:Mannosides; D009005:Monosaccharides; D011758:Pyrroles