Exploring the flap pocket of the antimalarial target plasmepsin II: the "55 % rule" applied to enzymes.
Zürcher
Martina
M
Laboratorium für Organische Chemie, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
Gottschalk
Thomas
T
Meyer
Solange
S
Bur
Daniel
D
Diederich
François
F
D000465:Algorithms; D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D001665:Binding Sites; D015195:Drug Design; D020128:Inhibitory Concentration 50; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D015800:Protozoan Proteins; D013329:Structure-Activity Relationship
D000962:Antimalarials; D011480:Protease Inhibitors; D015800:Protozoan Proteins; D016282:Aspartic Acid Endopeptidases; C100637:plasmepsin II