Hepatitis C virus and risk of non-Hodgkin lymphoma in British Columbia, Canada.
We investigated Hepatitis C virus (HCV) seropositivity and the risk of non-Hodgkin lymphoma (NHL) in a population-based case-control study in British Columbia, Canada. Cases were aged 20-79, diagnosed between March 2000 and February 2004, and resident in greater Vancouver or Victoria. Cases with HIV or a prior transplant were excluded. Controls were chosen from the Client Registry of the British Columbia (BC) Ministry of Health, and were age/sex/region frequency matched to cases. Antibodies for HCV were measured in 795 cases and 697 control subjects. HCV seropositivity was 2.4% in cases and 0.7% in controls [odds ratio (OR) = 2.6, 95% confidence interval (CI) = 0.9-7.4]. A significantly elevated risk was observed for B-cell lymphoma (OR = 2.9, 95%CI = 1.0-8.6). The highest risks were associated with diffuse large B-cell lymphoma (OR = 7.3, 95%CI = 2.1-25.0) and marginal zone lymphoma (OR = 6.1, 95%CI = 1.1-33.9). Our results provide further evidence that HCV infection contributes to NHL risk.
Spinelli
John J
JJ
BC Cancer Agency, Vancouver, British Columbia, Canada. jspinelli@bccrc.ca
Lai
Agnes S
AS
Krajden
Mel
M
Andonov
Anton
A
Gascoyne
Randy D
RD
Connors
Joseph M
JM
Brooks-Wilson
Angela R
AR
Gallagher
Richard P
RP
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D016174:Hepacivirus / Q000472:pathogenicity*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007124:Immunoenzyme Techniques; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors
D000914:Antibodies, Viral