title: Cigarette smoking induced liver insult concomitant with inflammatory mediators in serum crevicular fluid and bronchio alveolar lavage of schistosomal diabetic subjects with history of bronchial asthma.
abstract: Forty five smokers were classified into schistosomal cases with type-2 diabetis mellitus (GI) and with associated history of bronchial asthma (GII) and without T-2 DM (GIII). A control group (GIV) of non-diabetic non schistosomal age matched subjects who quitted smoking for >6 months were included. Assessed parameters included indices of glycemic status (glycated hemoglobin), angiogenesis (vascular endothelial growth factor) hepatic and bronchoalveolar disposition (Liver function test, metallothionein, serum levels of cotinine, cadmium selenium, copper & zinc) and bronchoalveolar lavage) (BAL) levels of surfactant proteins A & D, zinc and copper oxidative stress and fibrogenesis (total antioxidant capacity thiobarbituric acid reactive substance) and vasculopathy (angiotensin converting enzyme, P-selectin, nitrate) and periodontitis (collagenase and elastase in GCF) impact of cigarette smoking associated with trace element disbalance and enzymatic changes in crevicular fluid on altered parameters collaborative out-come. The study reflected the collaborative outcome of immune mediated mechanisms initiated by liver affection, glycemic status and history of predisposed bronchial integrity induced by oxidative stress.
authors.affiliation: Department of Medical Biochemistry, Faculties of Medicine, Tanta University, Tanta, Egypt.
authors.forename: Samia A
authors.initials: SA
authors.lastname: El-Dardiry
authors.forename: Sherine R
authors.initials: SR
authors.lastname: Shafik
authors.forename: Ayman
authors.initials: A
authors.lastname: Wagih
authors.forename: El-Amir M
authors.initials: el-AM
authors.lastname: Amir
authors.forename: Gamal K
authors.initials: GK
authors.lastname: Kassem
authors.forename: Ghada
authors.initials: G
authors.lastname: Atef
authors.forename: Heba
authors.initials: H
authors.lastname: El-Toukhy
mesh_terms: D000328:Adult; D000818:Animals; D001249:Asthma / Q000453:epidemiology / Q000378:metabolism; D018893:Bronchoalveolar Lavage; D001992:Bronchoalveolar Lavage Fluid; D016022:Case-Control Studies; D015897:Comorbidity; D003367:Cotinine / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000378:metabolism; D005883:Gingival Crevicular Fluid / Q000201:enzymology; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D012552:Schistosomiasis / Q000453:epidemiology / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects*
chemical_list: D003367:Cotinine