Synthesis and pharmacological activity of aminoindanone dimers and related compounds.
A series of N-substituted 3-aminoindanones were synthesised and evaluated for smooth muscle relaxant activity and mediator release inhibition effects. A low level of smooth muscle relaxant activity has been identified in all derivatives. Data have revealed that the significant mediator release inhibition effects observed are related to the nature of the amine substituents. A structure activity relationship is proposed.
Sheridan
H
H
Department of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland. hsheridn@tcd.ie
Butterly
S
S
Walsh
J J
JJ
Cogan
C
C
Jordan
M
M
Nolan
O
O
Frankish
N
N
D000588:Amines; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006632:Histamine; D007082:Ileum; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D000588:Amines; D007189:Indans; D006632:Histamine