title: Sparing the parotid glands and surgically transferred submandibular gland with helical tomotherapy in post-operative radiation of head and neck cancer: a planning study.
abstract: OBJECTIVE
  To evaluate the feasibility of sparing the parotid glands and surgically transferred submandibular gland (SMG) by intensity modulated radiotherapy (IMRT) in post-operative cases of head and neck cancer (HNC).
  
  
  METHODS
  Ten patients (larynx-2, base of tongue-4, tonsil-3, and unknown primary-1; pathologic stages III-IV) who underwent SMG transfers on the side of N0 neck along with definitive surgery were selected for this study. IMRT planning was done retrospectively using helical tomotherapy approach. Planning objective was to deliver 60 Gy to PTV1 and 54 Gy to PTV2 while maintaining the mean dose to the total parotid volume (TPV) and SMG less than 26 Gy.
  
  
  RESULTS
  The mean dose (+/-SD) to the TPV and SMG were 25+/-0.6 Gy and 23+/-1.9 Gy, respectively. The D(95) for PTV1 and PTV2 were 59.9+/-0.1 Gy and 54.9+/-0.3 Gy, respectively, satisfying our planning goal for PTV coverage. The D(99) for PTV1 and PTV2 were 58.2+/-0.7 Gy and 49.5+/-2.2 Gy, respectively, showing that sparing the salivary glands did not result in underdosing of the PTVs.
  
  
  CONCLUSIONS
  By combining the gland transfer and IMRT, the mean dose to TPV and transferred SMG could be reduced to less than 26 Gy in post-operative patients of HNC.
authors.affiliation: Division of Radiation Oncology, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Elantholi P
authors.initials: EP
authors.lastname: Saibishkumar
authors.forename: Naresh
authors.initials: N
authors.lastname: Jha
authors.forename: Rufus A
authors.initials: RA
authors.lastname: Scrimger
authors.forename: Marc A
authors.initials: MA
authors.lastname: MacKenzie
authors.forename: H
authors.initials: H
authors.lastname: Daly
authors.forename: Colin
authors.initials: C
authors.lastname: Field
authors.forename: Gino
authors.initials: G
authors.lastname: Fallone
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Parliament
mesh_terms: D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D010306:Parotid Gland / Q000528:radiation effects*; D011832:Radiation Injuries / Q000517:prevention & control; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012189:Retrospective Studies; D013363:Submandibular Gland / Q000528:radiation effects* / Q000601:surgery; D036542:Tomography, Spiral Computed / Q000379:methods*