Reaction of retinol with peroxynitrite.
The reactivity of retinol with peroxynitrite, which is a strong oxidant and has been reported to induce several biological damages, was investigated. 13-cis-14-nitroretinol (1), 13-trans-14-nitroretinol (2), 13-apo-beta-carotenone (3), retinal (4), 11,14-epoxyretinol (5), and 11,15-epoxyretinol (6) were identified as reaction products of retinol with peroxynitrite. From these results, it was observed that retinol can undergo a nitration reaction with peroxynitrite. Furthermore, the formation mechanisms of 1, 2, and 3 from retinol with peroxynitrite are discussed.
Suzuki
Rie
R
Faculty of Agriculture, Shizuoka University, Japan.
Kulkarni
Aditya
A
Yomoda
Yuya
Y
Kawagishi
Hirokazu
H
Terada
Yukimasa
Y
Maoka
Takashi
T
Etoh
Hideo
H
D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D009566:Nitrates / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D014801:Vitamin A / Q000737:chemistry / Q000378:metabolism*
D009566:Nitrates; D014801:Vitamin A; C039642:peroxynitric acid; D009584:Nitrogen