Tris buffer (THAM). An appraisal of its physiologic effects and clinical usefulness.
It has been the purpose of this discussion to review critically the physiologic considerations and clinical evidence regarding the use of Tris buffer in the treatment of acid-base disorders. It is concluded that there is little current evidence, theoretical, experimental, or clinical, to support the view that Tris has a significant therapeutic role. Some possible exceptions to this general conclusion are considered.
Bleich
H L
HL
Department of Medicine, Tufts University School of Medicine, Boston, USA.
Schwartz
W B
WB
D000138:Acidosis / Q000188:drug therapy*; D000142:Acidosis, Respiratory / Q000188:drug therapy; D000143:Acids / Q000506:poisoning*; D001793:Blood Preservation; D002021:Buffers; D019343:Citric Acid; D005947:Glucose / Q000031:analogs & derivatives; D006801:Humans; D011041:Poisoning / Q000188:drug therapy; D014325:Tromethamine / Q000494:pharmacology / Q000627:therapeutic use*
D000143:Acids; D002021:Buffers; D014325:Tromethamine; C002113:acid citrate dextrose; D019343:Citric Acid; D005947:Glucose