Determinants of urinary calcium and uric acid excretion in children after renal transplantation.
HC and HU predispose healthy children to develop hematuria and nephrolithiasis. The natural history of HC and HU has not been studied in renal transplant recipients who may be at greater risk of complications. Our study investigated the prevalence of HC and HU after Tx and determined independent predictors of urinary calcium and uric acid excretion. Twenty-five pediatric transplant patients were studied between one and 12 months after Tx. Demographic data and measurements of the random Uca/cr and uric acid excretion were collected. Multivariable regression analyses were used. The median age of the patients was 10.6 yr. The prevalence of HC and HU was 20% each at one month. At 12 months, 20% had HC and 13% had HU. There were no predictors for HC; for HU, the only predictor was systolic hypertension (p = 0.03). Our data demonstrate a high prevalence of HU and HC in pediatric renal Tx recipients. The long-term clinical implication of these metabolic abnormalities remains to be elucidated in prospective trials.
Peterson
J M
JM
Department of Pediatrics, University of California, Davis Medical Center, Sacramento, CA 95817, USA.
Butani
L
L
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000652:urine; D002118:Calcium / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006417:Hematuria / Q000453:epidemiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D053040:Nephrolithiasis / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology; D016559:Tacrolimus / Q000627:therapeutic use; D014527:Uric Acid / Q000652:urine*
D015415:Biomarkers; D007166:Immunosuppressive Agents; D014527:Uric Acid; D002118:Calcium; D016559:Tacrolimus