Insulin resistance in oligomenorrheic infertile women with non-polycystic ovary syndrome.
OBJECTIVE
To determine whether infertile oligomenorrheic women are insulin resistant, using an oral glucose tolerance test (OGTT).


METHODS
Retrospective study.


METHODS
National Center for Child Health and Development.


METHODS
One hundred twenty-seven infertile women with oligomenorrhea (oligomenorrheal group) and 177 infertile eumenorrheic women (normal menstrual group) were recruited.


METHODS
All women underwent an OGTT (75 g glucose).


METHODS
A homeostasis model assessment of insulin resistance (HOMA-IR), area under the curve (AUC) of insulin after the glucose load, and plasma insulin level at 120 minutes after glucose loading (IRI 120) were used as an index of insulin resistance.


RESULTS
The prevalence of insulin resistance (HOMA-IR >or=1.73) among oligomenorrheic women was 23.8%, which was significantly higher than that of eumenorrheic women, at 14.1%. The glucose AUCs (mean +/- SE) in the oligomenorrheal group (13,609 +/- 259 mg/min/dL) were similar to those for the normal menstrual groups (13,054 +/- 196 mg/min/dL), but the insulin AUCs of the oligomenorrheal group (5333 +/- 376 mU x min/L) were significantly higher than those of the normal menstrual groups (4517 +/- 266 mU x min/L).


CONCLUSIONS
The prevalence of insulin resistance assessed using an OGTT was significantly higher among infertile oligomenorrheic women with non-polycystic ovary syndrome than it was among women with normal menstrual cycles.
Ohgi
Shirei
S
Division of Reproductive Medicine, Department of Perinatal Medicine and Maternal Care, National Center for Child Health and Development, Tokyo, Japan. ohgi-s@ncchd.go.jp
Nakagawa
Koji
K
Kojima
Rieko
R
Ito
Megumu
M
Horikawa
Takashi
T
Saito
Hidekazu
H
D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D009839:Oligomenorrhea / Q000097:blood / Q000503:physiopathology*
D001786:Blood Glucose; D007328:Insulin