title: Lance-Adams syndrome: a report of two cases.
abstract: Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have undergone a cardiorespiratory arrest, regained consciousness afterwards, and then developed myoclonus days or weeks after the event. Worldwide, 122 cases have been reported in the literature so far, including 1 case of Chinese. Here we report 2 Chinese LAS patients with detailed neuroimagings. Cranial single photon emission computed tomography (SPECT) of patient 1, a 52-year-old woman, showed a mild hypoperfusion in her left temporal lobe, whereas patient 2, a 54-year-old woman, manifested a mild bilateral decrease of glucose metabolism in the frontal lobes and a mild to moderate decrease of the N-acetyl aspartate (NAA) peak in the bilateral hippocampi by cranial [(18)F]-fluorodeoxyglucose positron emission tomographic (PET) scan and cranial magnetic resonance spectroscopy (MRS), respectively. We also review the literature on the neuroimaging, pathogenesis, and treatment of LAS.
authors.affiliation: Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
authors.forename: Yan-xing
authors.initials: YX
authors.lastname: Zhang
authors.forename: Jian-ren
authors.initials: JR
authors.lastname: Liu
authors.forename: Biao
authors.initials: B
authors.lastname: Jiang
authors.forename: Hui-qin
authors.initials: HQ
authors.lastname: Liu
authors.forename: Mei-ping
authors.initials: MP
authors.lastname: Ding
authors.forename: Shui-jiang
authors.initials: SJ
authors.lastname: Song
authors.forename: Bao-rong
authors.initials: BR
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Huai-hong
authors.initials: HH
authors.lastname: Chen
authors.forename: Zhong-jin
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Jian-zheng
authors.initials: JZ
authors.lastname: Huang
mesh_terms: D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects*; D002524:Cerebellar Ataxia / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000209:etiology*; D008875:Middle Aged; D009207:Myoclonus / Q000175:diagnosis* / Q000209:etiology*; D013577:Syndrome