title: Efficacy of a topically applied formulation of metaflumizone on cats against the adult cat flea, flea egg production and hatch, and adult flea emergence.
abstract: A spot-on metaflumizone formulation was evaluated to determine its adulticidal efficacy, effect upon egg production, and ovicidal activity when applied to flea infested cats. Eight male and eight female adult domestic shorthair cats were randomly assigned to either serve as non-treated controls or were treated topically with a minimum of 40mg/kg metaflumizone in single spot-on Day 0. On Days -2, 7, 14, 21, 28, 35, 42, 49, and 56, each cat was infested with approximately 100 unfed cat fleas, Ctenocephalides felis felis. On Days 1, 2, and 3, and at 48 and 72h after each post-treatment reinfestation, flea eggs were collected and counted. At approximately 72h after treatment or infestation, each cat was combed to remove and count live fleas. Egg viability was determined by examining hatched eggs after 5 days and adult emergence was determined 28 days after egg collection. Metaflumizone provided >/=99.6% efficacy against adult fleas from Days 3 to 45 following a single application. Following treatment, egg production fell by 51.6% within 24h and 99.2% within 48h. Following subsequent weekly infestations egg production from treated cats was negligible out to Day 38, with >/=99.5% reduction relative to non-treated cats. Where there were eggs to evaluate, metaflumizone treatment did not have any apparent effect on the hatching of eggs or on the development and emergence of adult fleas from the eggs produced by fleas from treated animals.
authors.affiliation: Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66503, United States. Dryden@vet.ksu.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Dryden
authors.forename: Patricia
authors.initials: P
authors.lastname: Payne
authors.forename: Amy
authors.initials: A
authors.lastname: Lowe
authors.forename: Sara
authors.initials: S
authors.lastname: Mailen
authors.forename: Vicki
authors.initials: V
authors.lastname: Smith
authors.forename: Douglas
authors.initials: D
authors.lastname: Rugg
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007306:Insecticides / Q000633:toxicity; D008018:Life Cycle Stages / Q000187:drug effects; D008297:Male; D010058:Oviposition / Q000187:drug effects; D010270:Parasite Egg Count / Q000662:veterinary; D011897:Random Allocation; D012664:Semicarbazones / Q000633:toxicity; D005423:Siphonaptera
chemical_list: D007306:Insecticides; D012664:Semicarbazones; C528570:metaflumizone