[Genetic basis of ankylosing spondylitis].
Ankylosing spondylitis (AS) is a common rheumatic condition, highly heritable. Much of the genetic contribution to the disease lies in the major histocompatibility complex (MHC). The association with the allele group HLA-B*27 has been described worldwide for 30 years. On the other hand, genome wide scans have provided some interesting results showing that other MHC and non-MHC genes could be implicated either in disease susceptibility and phenotypic manifestations. Different hypothesis for disease pathophysiology have been investigated which contribute for a better understanding of the genetic basis of AS. This review aims to summarize the status of the knowledge in this exciting area. New data may, in a near future, change the screening of patients and generate new insights for the emergence of novel therapies.
Santos
F Pimentel dos
FP
Serviço de Reumatologia do CHLO EPE, Hospital de Egas Moniz, Lisbon. pimentel.santos@gmail.com
Bastos
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Ligeiro
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Mourão
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AF
Chaves
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Trindade
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Guedes-Pinto
H
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Branco
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JC
D015235:HLA-B Antigens / Q000235:genetics; D015796:HLA-B27 Antigen / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000235:genetics*
D015235:HLA-B Antigens; D015796:HLA-B27 Antigen