[Experimental model of activated Lamblia (Giardia) muris infection in albino mice].
Experimental L. muris infection was reproduced in 100% of the intact albino mice intragastrically given levomycin in an average total dose of 15.88-34.84 or 0.88-1.02 g/kg for 18-34 days. With levomycin administration, the intensity of giardiasis was 1121.6-8540.1 (mean 4830.9) thousand L. muris trophozoites per animal. The total number of trophozoites per animal decreased to 302.2-3481.4 (mean 1546.4) thousand and 28.1-324.0 (mean 109.4) thousand specimens 5-8 and 11-13 days after discontinuation of the antibiotic, respectively. The maximum number of L. muris trophozoites was observed in the proximal and middle portions of the murine small intestine during and after the administration oflevomycin. The highest isolation of cysts was seen 12-14 days after the initiation of administration of the antibiotic. Following 8-10 days of terminations of a course of levomycin therapy the native smear of animal feces showed no Lamblia cysts. In mice with activated infection, the isolation rate of Lamblia cysts was directly related to the intensity of intestinal infection with trophozoites of the parasite.
Irikov
O A
OA
Kovalenko
F P
FP
D000818:Animals; D002701:Chloramphenicol / Q000008:administration & dosage; D004195:Disease Models, Animal; D005243:Feces / Q000469:parasitology; D005872:Giardia / Q000302:isolation & purification / Q000472:pathogenicity; D005873:Giardiasis / Q000469:parasitology / Q000503:physiopathology*; D007421:Intestine, Small / Q000469:parasitology; D008297:Male; D051379:Mice; D010270:Parasite Egg Count; D013997:Time Factors; D014774:Virulence
D002701:Chloramphenicol