title: Effects of various forms of calcium on body weight and bone turnover markers in women participating in a weight loss program.
abstract: OBJECTIVE
  This study examined the effects of calcium intake on body weight, body fat, and markers of bone turnover in pre-menopausal adult women undergoing a 12 week weight loss program of diet and exercise.
  
  
  METHODS
  Subjects were prescribed a 12 week diet with a 500 Kcal restriction containing about 750 mg calcium/day, exercised 3 times/week, and were given either placebo capsules, capsules of calcium lactate or calcium phosphate (daily dose about 800 mg calcium), or low fat milk (daily dose about 800 mg calcium). Subjects completed and returned daily diet diaries weekly.
  
  
  RESULTS
  Daily calcium intake in mg from diet records + supplement assignment was: 788 +/- 175 (placebo), 1698 +/- 210 (Ca lactate), 1566 +/- 250 (Ca phosphate), 1514 +/- 225 (milk)(no significant differences among the calcium and milk groups). Each group had statistically significant changes in body weight (p < 0.01), but there were no significant differences among groups for the weight loss: 5.8 +/- 0.8 kg (placebo), 4.1 +/- 0.7 kg (Ca lactate), 5.4 +/- 1.3 kg (Ca phosphate), 4.2 +/- 0.8 kg (milk). Body fat was changed significantly in each group (p < 0.01), with milk group showing a little less change than the other groups. Serum bone specific alkaline phophatase activity, a bone synthesis marker, increased similarly in all groups (p < 0.001 within groups, no significance for changes among groups). In contrast, the Ca lactate group, but not other groups, had a drop in urine values for alpha helical peptide, a bone resorption marker (p < 0.05).
  
  
  CONCLUSIONS
  For the conditions of this study, increased calcium intake, by supplement or milk, did not enhance loss of body weight or fat, though calcium lactate supplementation lowered values for a marker of bone degradation.
authors.affiliation: Human Nutrition, The Ohio State University, 345 Campbell Hall, 1787 Neil Ave, Columbus, OH 43210-1295, USA.
authors.forename: Ginger
authors.initials: G
authors.lastname: Wagner
authors.forename: Shirley
authors.initials: S
authors.lastname: Kindrick
authors.forename: Steven
authors.initials: S
authors.lastname: Hertzler
authors.forename: Robert A
authors.initials: RA
authors.lastname: DiSilvestro
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism*; D017610:Calcium Compounds / Q000008:administration & dosage; D002130:Calcium Phosphates / Q000008:administration & dosage; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000494:pharmacology; D002214:Capsules; D002417:Cattle; D004038:Diet, Reducing; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D007773:Lactates / Q000008:administration & dosage; D008875:Middle Aged; D008892:Milk / Q000737:chemistry; D009765:Obesity / Q000178:diet therapy / Q000188:drug therapy / Q000628:therapy*; D017697:Premenopause; D015431:Weight Loss / Q000187:drug effects / Q000502:physiology
chemical_list: D019440:Anti-Obesity Agents; D050071:Bone Density Conservation Agents; D017610:Calcium Compounds; D002130:Calcium Phosphates; D002136:Calcium, Dietary; D002214:Capsules; D007773:Lactates; C110051:calcium lactate; C020243:calcium phosphate; D000469:Alkaline Phosphatase