A new asymmetric synthesis of the anti-tumor alkaloid (R)-(+)-crispine A.
We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.
Allin
Steven M
SM
Department of Chemistry and Department of Chemical Engineering, Loughborough University, Loughborough, Leicestershire, UK. s.m.allin@lboro.ac.uk
Gaskell
Sean N
SN
Towler
Joannah M R
JM
Page
Philip C Bulman
PC
Saha
Basu
B
McKenzie
Michael J
MJ
Martin
William P
WP
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D012015:Reference Standards; D013237:Stereoisomerism
D000470:Alkaloids; D000970:Antineoplastic Agents; D007546:Isoquinolines; C523713:crispine A