title: Benefits of a beta-blocker for intractable hemolysis due to paraprosthetic leakage.
abstract: We describe a 58-year-old man who was successfully treated with a beta-adrenergic receptor blocking agent for intractable hemolysis due to paraprosthetic leakage. After replacement of a mitral prosthetic valve with another mechanical valve, the patient suffered intractable intravascular hemolysis resulting from recurrent paraprosthetic leakage. With oral administration of a beta-adrenergic receptor blocker, betaxolol hydrochloride, for 3 months, the hemoglobin value increased from 9.7 g x dL(-1) to 12.4 g x dL(-1), although glutamic oxaloacetic transaminase and lactic dehydrogenase values remained elevated.
authors.affiliation: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. aoyagi@med.kurume-u.ac.jp
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Aoyagi
authors.forename: Shuji
authors.initials: S
authors.lastname: Fukunaga
authors.forename: Eiki
authors.initials: E
authors.lastname: Tayama
authors.forename: Eiji
authors.initials: E
authors.lastname: Nakamura
authors.forename: Noriko
authors.initials: N
authors.lastname: Egawa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Hosokawa
mesh_terms: D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000743:Anemia, Hemolytic / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D001219:Aspartate Aminotransferases / Q000097:blood; D015784:Betaxolol / Q000008:administration & dosage / Q000627:therapeutic use*; D001705:Bioprosthesis; D020878:Device Removal; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012086:Reoperation; D013314:Stress, Mechanical; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D006454:Hemoglobins; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D015784:Betaxolol