title: A practical synthesis of differentially protected 2-(hydroxymethyl)piperazines.
abstract: An efficient and scalable synthesis of three differentially protected 2-(hydroxymethyl)piperazines is presented, starting from optically active and commercially available (2S)-piperazine-2-carboxylic acid dihydrochloride. These synthetic building blocks are useful in the preparation of biologically active compounds and as chemical scaffolds for the construction of combinatorial libraries.
authors.affiliation: Pfizer Global Research and Development, 34790 Ardentech Court, Fremont, California 94555, USA.
authors.forename: Hongwu
authors.initials: H
authors.lastname: Gao
authors.forename: Adam R
authors.initials: AR
authors.lastname: Renslo
mesh_terms: D008968:Molecular Conformation; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010879:Piperazines