title: The pretransplant Follicular Lymphoma International Prognostic Index is associated with survival of follicular lymphoma patients undergoing autologous hematopoietic stem cell transplantation.
abstract: We retrospectively evaluated the association of the Follicular Lymphoma International Prognostic Index (FLIPI) and other characteristics with survival following high-dose therapy and autologous stem cell transplantation (ASCT) in 207 consecutive follicular lymphoma (FL) patients. The FLIPI was associated with OS both when evaluated as a categorical variable (0 - 1 vs. 2 vs. 3 vs. 4, p = 0.01, global test) and a continuous linear variable (p = 0.002). The association of FLIPI with survival appeared to be more relevant for patients who received standard conditioning regimens compared to those that were treated with high-dose radioimmunotherapy (p = 0.004). Among all patients, mortality was also associated with chemosensitive disease (HR = 0.47, p = 0.01) or untreated relapse (HR = 0.20, p = 0.0002) vs. chemoresistant disease, and > or =2 extranodal sites (HR = 2.82, p = 0.03) after adjusting for FLIPI. These data suggest that the FLIPI and select non-FLIPI factors after adjustment for the FLIPI are associated with survival in FL patients undergoing ASCT.
authors.affiliation: Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA, USA.
authors.forename: Grant E
authors.initials: GE
authors.lastname: Keeney
authors.forename: Ted A
authors.initials: TA
authors.lastname: Gooley
authors.forename: Rosalyn N
authors.initials: RN
authors.lastname: Pham
authors.forename: Oliver W
authors.initials: OW
authors.lastname: Press
authors.forename: John M
authors.initials: JM
authors.lastname: Pagel
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Petersdorf
authors.forename: David G
authors.initials: DG
authors.lastname: Maloney
authors.forename: William
authors.initials: W
authors.lastname: Bensinger
authors.forename: Leona
authors.initials: L
authors.lastname: Holmberg
authors.forename: Ajay K
authors.initials: AK
authors.lastname: Gopal
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D016499:Radioimmunotherapy / Q000379:methods; D019172:Transplantation Conditioning / Q000379:methods; D016896:Treatment Outcome