title: Activation of the prefrontal cortex during the wisconsin card sorting test (Keio Version) as measured by two-channel near-infrared spectroscopy in patients with traumatic brain injury.
abstract: To investigate brain activation in the prefrontal cortex (PFC) during the Wisconsin Card Sorting Test (Keio Version) (KWCST), we examined changes in total hemoglobin volume (THV) in 8 patients with traumatic brain injury (TBI) and 20 healthy control subjects using two-channel near-infrared spectroscopy. As a result, average THV in the right PFC during KWCST in TBI patients (-0.131 +/- 0.127) was significantly lower than in control subjects (0.016 +/- 0.135) (2 x 3 ANOVA; p < 0.05). These results demonstrated that the TBI patients had lower circulation of hemoglobin in the right PFC during the KWCST than the control subjects.
authors.affiliation: Department of Rehabilitation Medicine, Jikei University School of Medicine, Tokyo, Japan. keiman@jikei.ac.jp
authors.forename: Keiji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Go
authors.initials: G
authors.lastname: Uruma
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abo
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003657:Decision Making / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010108:Oxyhemoglobins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000503:physiopathology*; D019265:Spectroscopy, Near-Infrared
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins