title: Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy.
abstract: Eight d-ribo-phytosphingosine derivatives were synthesized from d-ribo-phytosphingosine and diverse acyl chlorides with N,N-diisopropylethylamine in tetrahydrofuran for 1h at room temperature. Effect of these compounds on IR-induced cell death was evaluated on blood cancer cells (Jurkat). Among these, 3d showed the highest enhancement of radiosensitizing effect.
authors.affiliation: Laboratory of Radiopharmaceuticals, Korea Institute of Radiological and Medical Sciences, 215-4 Gongneungdong, Nowongu, Seoul 139-706, Republic of Korea.
authors.forename: Byung Seok
authors.initials: BS
authors.lastname: Moon
authors.forename: Moon-Taek
authors.initials: MT
authors.lastname: Park
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Park
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Kim
authors.forename: Kyo Chul
authors.initials: KC
authors.lastname: Lee
authors.forename: Gwang Il
authors.initials: GI
authors.lastname: An
authors.forename: Seung Dae
authors.initials: SD
authors.lastname: Yang
authors.forename: Dae Yoon
authors.initials: DY
authors.lastname: Chi
authors.forename: Gi Jeong
authors.initials: GJ
authors.lastname: Cheon
authors.forename: Su-Jae
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D003131:Combined Modality Therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D019169:Jurkat Cells; D015458:Leukemia, T-Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use
chemical_list: D011838:Radiation-Sensitizing Agents; C012491:phytosphingosine; D013110:Sphingosine