A discrete area within the left dorsolateral prefrontal cortex involved in visual-verbal incongruence judgment.
The role of the frontal lobe in cross-modal visual-auditory processing has been documented in experiments using incongruent/congruent paradigms. In this study, 4 patients with left frontal World Health Organization Grade II glioma were assessed during pre-, intra-, and postoperative sessions with picture-naming and verbal-visual task requiring judgment of congruence between pictures and words. During awake brain surgery, the naming and cross-modal tasks were coupled with electrical stimulation inactivating restricted specific regions. For all patients, focal brain stimulation in the dorsolateral prefrontal cortex elicited picture-word matching disturbances but no naming impairment, and the elicited errors exclusively appeared in incongruent and not congruent conditions. The dissociation observed between correct picture naming and disturbed cross-modal judgment shows that electrical stimulation of a discrete cortical area within the left dorsolateral prefrontal cortex can inhibit the simultaneous processing of visual-verbal information without disturbing larger networks involved in the naming process.
Plaza
Monique
M
Laboratoire de Psychologie et de Neurosciences Cognitives, FRE 2987 (CNRS/Université de Paris V René Descartes), Institut de Psychologie, 71 avenue Edouard Vaillant, 92774 Boulogne Billancourt, France. monique.plaza@univ-paris5.fr
Gatignol
Peggy
P
Cohen
Henri
H
Berger
Brigitte
B
Duffau
Hugues
H
D000328:Adult; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006801:Humans; D007600:Judgment / Q000502:physiology*; D008297:Male; D010775:Photic Stimulation / Q000379:methods; D017397:Prefrontal Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D013060:Speech / Q000502:physiology; D014705:Verbal Behavior / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*