microRNAs join the p53 network--another piece in the tumour-suppression puzzle.
Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.
He
Lin
L
Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
He
Xingyue
X
Lowe
Scott W
SW
Hannon
Gregory J
GJ
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics; D015513:Oncogene Proteins / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D034622:RNA Interference / Q000502:physiology; D018510:RNA, Helminth / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; D035683:MicroRNAs; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D018510:RNA, Helminth; D016159:Tumor Suppressor Protein p53