[The role of mucoprotective drugs in a treatment and prevention for NSAID-induced gastric ulcer].
NSAIDs compromise gastroduodenal defense mechanism mediated by inhibiting cyclooxygenase and leading to leukocyte infiltration or neutrophil adherence, and cause gastric ulcers. There are a number of mucoprotective drugs in Japan, and they were often used for NSAIDs-induced ulcer treatment. In vitro or in vivo studies, some mucoprotective drugs have been shown to have anti-inflammatory action due to the inhibition of leukocyte infiltration, production of inflammatory cytokines. However, mucoprotective drugs were given a low priority in "the Japanese guideline for the management of gastric ulcer" edited in 2003. Therefore, mucoprotective drugs should be investigated in terms of effects on NSAIDs-induced gastric ulcer patients because there are a few reliable evidences for the treatment of NSAID-induced gastric ulcer in Japan.
Okuyama
Masatsugu
M
Department of Gastroenterology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases.
Tominaga
Kazunari
K
Tanigawa
Tetsuya
T
Shiba
Masatsugu
M
Watanabe
Toshio
T
Fujiwara
Yasuhiro
Y
Oshitani
Nobuhide
N
Higuchi
Kazuhide
K
Arakawa
Tetsuo
T
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal