title: Penetration of topically applied tacrolimus into the aqueous humor in Behçet's disease.
abstract: We investigated the concentration of tacrolimus in aqueous humor, and serum of patients with ocular Behçet's disease after topical application in 11 patients. All received 1 drop of isotonic tacrolimus solution 0.3% every 6 hours for 3 days. The mean tacrolimus concentration in the aqueous and serum, as measured by microparticle enzyme immunoassay, were 12.49 and 0.76 ng/mL, respectively. Tacrolimus may be a promising treatment modality in anterior uveitis in Behçet's disease by topical application.
authors.affiliation: Ophthalmology Department, Ankara University Faculty of Medicine, Esat Caddes i 74/3 Küçükesat, Ankara, 06660, Turkey. yalcinda@medicine.ankara.edu.tr
authors.forename: F Nilüfer
authors.initials: FN
authors.lastname: Yalçindağ
authors.forename: Figen
authors.initials: F
authors.lastname: Batioğlu
authors.forename: Ozden
authors.initials: O
authors.lastname: Ozdemir
mesh_terms: D000042:Absorption / Q000187:drug effects / Q000502:physiology; D000287:Administration, Topical; D000328:Adult; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism*; D001528:Behcet Syndrome / Q000188:drug therapy* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D016559:Tacrolimus / Q000008:administration & dosage* / Q000493:pharmacokinetics*
chemical_list: D016559:Tacrolimus