CD14+ monocyte levels in subgroups of acute coronary syndromes.
OBJECTIVE
We aimed to investigate whether there were any differences in the percentages of CD14(+) monocytes between subgroups of acute coronary syndromes (ACS). CD14(+) is a monocyte surface receptor that plays a role in the innate immune system. CD14(+) monocytes are associated with complications of atherosclerosis.


METHODS
In total we enrolled 115 patients with ACS: 24 with unstable angina (UA); 29 with non-ST elevation myocardial infarction (NSTEMI); and 62 with ST elevation myocardial infarction (STEMI). The levels of C-reactive protein and percentage of CD14(+) monocyte were measured on admission.


RESULTS
CD14(+) monocyte percentages were observed to be different between groups by analysis of variance test. The percentages of CD14(+) monocyte were 81.24+/-10.04% in the UA group; 89.40+/-5.84% in the NSTEMI group; and 87.22+/-11.75% in the STEMI group (P=0.013). The differences between the UA and the NSTEMI and between the UA and the STEMI groups with Bonferroni posthoc testing were significant (P=0.014 and P=0.049 respectively). Moreover, no significant difference was found between the NSTEMI and STEMI groups (P=1.000). The C-reactive protein levels in the UA group were detected to be significantly low with Bonferroni posthoc testing compared with both the NSTEMI and STEMI groups (for both comparisons, P<0.002).


CONCLUSIONS
A significant difference in CD14(+) monocyte percentages between subgroups of ACS was determined. CD14(+) monocyte percentages can be a useful parameter in differentiating between the subgroups of ACS, especially between UA and myocardial infarction.
Ozdogru
Ibrahim
I
Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey. iozdogru@erciyes.edu.tr
Inanc
Mehmet Tugrul
MT
Eryol
Namk Kemal
NK
Dogan
Ali
A
Kaya
Mehmet Gungor
MG
Gul
Ibrahim
I
Kalay
Nihat
N
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000378:metabolism*; D000368:Aged; D050197:Atherosclerosis / Q000150:complications; D002097:C-Reactive Protein / Q000096:biosynthesis; D002309:Cardiology / Q000379:methods; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009000:Monocytes / Q000378:metabolism; D009203:Myocardial Infarction / Q000097:blood* / Q000378:metabolism; D016896:Treatment Outcome
D018950:Lipopolysaccharide Receptors; D002097:C-Reactive Protein