title: Genetic control of immune response in carriers of the 8.1 ancestral haplotype: correlation with levels of IgG subclasses: its relevance in the pathogenesis of autoimmune diseases.
abstract: Ancestral haplotype (AH) 8.1(HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201) seems to be associated with susceptibility to autoimmune diseases. Different mechanisms are probably involved in increasing autoimmunity, such as unbalanced cytokine production and the lack of C4A protein. So AH 8.1 modifies immune response in many ways. In this study we demonstrate that IgG2 serum levels were significantly lower in 8.1 AH carriers than in 8.1 AH non-carriers. On the contrary, as regards IgG1, IgG3, IgG4 serum levels, no significant differences were observed between the two groups. In AH 8.1 carriers low IgG2 levels might take to slower clearance of the infectious agent and hence to a lasting presence of it. The persistence of infectious antigens could determine an increased production of autoantibodies with a higher risk of cross-reactions.
authors.affiliation: Laboratorio di Immunopatologia, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Corso Tukory 211, 90134 Palermo, Italy. gcandore@unipa.it
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Candore
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Campagna
authors.forename: Irene
authors.initials: I
authors.lastname: Cuppari
authors.forename: Daniele
authors.initials: D
authors.lastname: Di Carlo
authors.forename: Claudia
authors.initials: C
authors.lastname: Mineo
authors.forename: Calogero
authors.initials: C
authors.lastname: Caruso
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D015795:HLA-B8 Antigen / Q000097:blood / Q000145:classification / Q000276:immunology; D015803:HLA-DR3 Antigen / Q000097:blood / Q000145:classification / Q000276:immunology; D006239:Haplotypes / Q000235:genetics* / Q000276:immunology*; D006579:Heterozygote; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D007074:Immunoglobulin G