Urinary profile of 6 beta-hydroxycortisol in workers exposed to aluminum.
The aim of the present study was to evaluate whether aluminum exposure may cause alterations of cytochrome P4503A4 by measuring the urinary excretion of 6 beta-hydroxycortisol as biomarker. There is a positive correlation between urinary 6 beta-hydroxycortisol and aluminum excretion (p < 0.05). The correlations between occupational duration, smoking habits, and age were also evaluated. The increased excretion of the biomarker suggests that this element may induce formation of cytochrome P 450 in exposed individuals.
Baydar
T
T
Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Sihhiye, Ankara, Turkey.
Aydin
A
A
Sahin
G
G
D000328:Adult; D000535:Aluminum / Q000009:adverse effects* / Q000652:urine; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000652:urine; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure
C001380:6 beta-hydroxycortisol; D000535:Aluminum; D006854:Hydrocortisone