title: Initial management of an outbreak of the HTLV-1 virus in Nunavut, Canada.
abstract: BACKGROUND
  HTLV-1 is a retrovirus known to be endemic in Japan, the Caribbean, and parts of Africa. HTLV-1 infection is rare in Canada. The last known cases prior to the present cluster in Nunavut occurred in 1993, when three Aboriginal patients with neurological symptoms in British Columbia were found to be infected with HTLV-1. The Dept. of Health and Social Services in Nunavut became aware of the presence of this virus in the Nunavut population in early June, 2005 when an individual infected with HTLV-1 died from Acute T-cell leukemia.
  
  
  METHODS
  A report of the interventions done by the Department in response to this outbreak.
  
  
  METHODS
  Interviews with the key informants in the Department. A review of the record of meetings, community consultations, expert consultations and communiqués was conducted. Key information points were summarized.
  
  
  RESULTS
  A Nunavut Dept. of Health and Social Services Task Force on HTLV-1 was established. Investigation of the population in the community in which the index case was found using blood samples to identify the virus in the carriers and for antibodies in first-degree relatives of the carriers. A literature review and summary of the epidemiology of the cluster was performed. An intense educational and counseling program regarding HTLV-1 infection was initiated for the (200) health care workers in the Territory and residents in the affected communities. A territory wide publicity and educational package was developed and implemented via meetings, press conferences, and telehealth sessions. Clinical protocols for monitoring the health status of infected individuals have been implemented. Ante-natal screening for HTLV-1 has been initiated, Territory-wide. An unlinked, anonymous HTLV-1 seroprevalence study began in early 2006. To date, approximately 300 persons have been tested for HTLV-1 in Nunavut. The number of infected individuals is less than 20.
  
  
  CONCLUSIONS
  HTLV-1 infection is present in Nunavut. The prevalence is unknown. There has been at least one death from Acute T-cell leukemia in an individual infected. Prenatal screening and the seroprevalence study should provide important information on the breadth of the problem and allow the Department to implement appropriate measures to better manage the spread of the virus and the clinical cases of those infected with it.
authors.affiliation: Department of Health and Social Services, Government of Nunavut, Nunavut, Canada. isobol@gov.nu.ca
authors.forename: Isaac
authors.initials: I
authors.lastname: Sobol
authors.forename: Carolina
authors.initials: C
authors.lastname: Palacios
authors.forename: Geraldine
authors.initials: G
authors.lastname: Osborne
authors.forename: Joe
authors.initials: J
authors.lastname: Hildes
authors.forename: William
authors.initials: W
authors.lastname: MacDonald
authors.forename: Amy
authors.initials: A
authors.lastname: Harty
authors.forename: Igah
authors.initials: I
authors.lastname: Sanguya
authors.forename: Mark
authors.initials: M
authors.lastname: Gilbert
mesh_terms: D000208:Acute Disease; D000998:Antiviral Agents / Q000627:therapeutic use; D002170:Canada / Q000453:epidemiology; D006800:Deltaretrovirus Infections / Q000453:epidemiology*; D004196:Disease Outbreaks / Q000517:prevention & control*; D019538:Health Care Surveys; D015368:Human T-lymphotropic virus 1; D006801:Humans; D007407:Interviews as Topic; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy / Q000453:epidemiology; D020957:Nunavut / Q000453:epidemiology; D016730:Program Development; D015397:Program Evaluation
chemical_list: D000998:Antiviral Agents