Assessment of risk factors for cardiovasuclar disease in pediatric renal transplant patients.
Pediatric renal TP recipients are at risk for CVD. We performed a cross-sectional study of the prevalence of RF for CVD in 45 long-term pediatric renal TP patients. The time since TP was 42 months. The GFR was 87.8 +/- 3.4 mL/min/1.73 m(2); 25/45 (56%) had Stage 2-4 CKD. A total of 33% had elevated SBP and 24% had high DBP; 57% had elevated SBP or DBP. A total of 20% had elevated serum CHOL levels, while 45% had high serum TG levels. A total of 42% had high HCY levels and 50% had low HCT levels. The vast majority (66.7%) had at least two RF for CVD. A total of 18.2% had abnormal post-TP echocardiography results. There was a negative correlation between GFR and SBP, DBP, serum CHOL, HCY, and BMI. There was a positive correlation between GFR and HCT. Serum CHOL was significantly lower and SBP and DBP trended lower in patients on a SF immunosuppression regimen. Similarly, SBP and DBP trended higher and CHOL was significantly higher in patients receiving SRL vs. mycophenolate mofetil. We conclude that the majority of pediatric renal TP patients exhibit multiple CVD RF.
Silverstein
Douglas M
DM
Department of Pediatrics, Division of Nephrology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. dsilve@lsuhsc.edu
Mitchell
Miranda
M
LeBlanc
Pamela
P
Boudreaux
J Philip
JP
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D002102:Cadaver; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000503:physiopathology; D002648:Child; D003430:Cross-Sectional Studies; D004452:Echocardiography; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D019520:Living Donors; D018579:Patient Selection; D011183:Postoperative Complications / Q000453:epidemiology*; D012307:Risk Factors; D014019:Tissue Donors