CSF biomarkers in the evaluation of idiopathic normal pressure hydrocephalus.
BACKGROUND - To evaluate cerebrospinal fluid (CSF) markers for neuronal degeneration and demyelination in idiopathic normal pressure hydrocephalus (INPH), subcortical arteriosclerotic encephalopathy (SAE), and neurologically healthy subjects. METHODS - Lumbar CSF concentrations of sulfatide, neurofilament protein light (NFL), total-tau (T-tau), hyperphosphorylated tau (P-tau), and beta-amyloid(1-42) (Abeta42) were analyzed in 62 INPH patients, 26 SAE patients, and 23 neurologically healthy controls. In INPH patients, samples before and after shunt surgery were analysed. RESULTS - The CSF concentration of NFL was elevated in INPH and SAE compared with the controls, and levels of T-tau, P-tau, and Abeta42 were lower in INPH compared with SAE and controls. No difference was seen for sulfatide. All markers except Abeta42 were significantly elevated after shunt surgery. CONCLUSIONS - The most striking finding was the power of the combined pattern of NFL, P-tau, and Abeta42 in distinguishing between the clinical diagnoses of INPH, SAE, and neurologically healthy elderly.
Agren-Wilsson
A
A
Department of Clinical Neuroscience, Umeå University, Umeå, Sweden. aina.agren.wilsson@neuro.umu.se
Lekman
A
A
Sjöberg
W
W
Rosengren
L
L
Blennow
K
K
Bergenheim
A T
AT
Malm
J
J
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000032:analysis / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D002557:Cerebrospinal Fluid Shunts; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000503:physiopathology; D002537:Intracranial Arteriosclerosis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000503:physiopathology; D019586:Intracranial Hypertension / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000209:etiology; D016900:Neurofilament Proteins / Q000032:analysis / Q000134:cerebrospinal fluid; D010446:Peptide Fragments / Q000032:analysis / Q000134:cerebrospinal fluid; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013433:Sulfoglycosphingolipids / Q000032:analysis / Q000134:cerebrospinal fluid; D015854:Up-Regulation / Q000502:physiology; D016875:tau Proteins / Q000032:analysis / Q000134:cerebrospinal fluid
D016229:Amyloid beta-Peptides; D015415:Biomarkers; D016900:Neurofilament Proteins; D010446:Peptide Fragments; D013433:Sulfoglycosphingolipids; C075222:amyloid beta-protein (1-42); C044882:neurofilament protein L; D016875:tau Proteins