Life style-related diseases of the digestive system: colorectal cancer as a life style-related disease: from carcinogenesis to medical treatment.
Life style-related diseases are associated with an increased risk of colorectal cancer (CRC). Recently, an association has been demonstrated between obesity and CRC. CRC has been associated with markers of insulin or glucose control, and insulin resistance might be the unifying mechanism by which several risk factors affect colorectal carcinogenesis. We evaluated the association between the number of aberrant crypt foci (ACF) and obesity, insulin resistance, hyperlipidemia, and other factors of life style-related disease. As a result, age, body mass index (BMI), waist circumference, and visceral fat obesity were significantly associated with the number of ACF. These results suggest that visceral fat obesity is an important target for CRC prevention. Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor superfamily and is highly expressed in CRC. PPARgamma ligand administration for 1 to 8 months significantly reduced the number of ACF in human subjects. PPARgamma ligand is a promising candidate as a chemopreventive agent. Further investigation is needed to elucidate these mechanisms.
Takahashi
Hirokazu
H
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yoneda
Kyoko
K
Tomimoto
Ayako
A
Endo
Hiroki
H
Fujisawa
Toshio
T
Iida
Hiroshi
H
Mawatari
Hironori
H
Nozaki
Yuichi
Y
Ikeda
Tamon
T
Akiyama
Tomoyuki
T
Yoneda
Masato
M
Inamori
Masahiko
M
Abe
Yasunobu
Y
Saito
Satoru
S
Nakajima
Atsushi
A
Nakagama
Hitoshi
H
D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D048909:Diabetes Complications; D006801:Humans; D007333:Insulin Resistance; D008019:Life Style; D008024:Ligands; D009765:Obesity / Q000150:complications; D047495:PPAR gamma / Q000187:drug effects / Q000378:metabolism; D011230:Precancerous Conditions / Q000209:etiology*; D012307:Risk Factors
D008024:Ligands; D047495:PPAR gamma