title: [Expression of augmenter of liver regeneration in cryptorchidism spermatogenic cells and its implication].
abstract: OBJECTIVE
  To investigate the expression of the augmenter of liver regeneration (ALR) in cryptorchidism spermatogenic cells.
  
  
  METHODS
  Twenty cryptorchidism rat models were established by surgery, 10 included as normal controls and anther 10 as sham-surgery controls. The expression of ALR was detected by immunochemistry, the COX II level measured by immunofluorescence and the ferric iron contents assayed by Perls stain.
  
  
  RESULTS
  ALR expressed intensively in the spermatogonia of the control groups but in a signigicantly diminished manner in the cryptorchidism group. No significant difference was found in the COX II level between any two groups of the same age. Ferric iron content of the PND30 cryptorchids decreased significantly (P < 0.05).
  
  
  CONCLUSIONS
  ALR may play an important role in early spermatogenesis. Metabolism dysfunctions caused by ALR defection might be a crucial mechanism for aspermatogenesis of cryptorchidism.
authors.affiliation: Department of Anesthesiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China. novembermarie@163.com
authors.forename: Xuan
authors.initials: X
authors.lastname: Chen
authors.forename: De-ying
authors.initials: DY
authors.lastname: Zhang
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.forename: Guang-hui
authors.initials: GH
authors.lastname: Wei
mesh_terms: D000818:Animals; D003456:Cryptorchidism / Q000378:metabolism / Q000473:pathology*; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004195:Disease Models, Animal; D005455:Fluorescent Antibody Technique; D005854:Germ Cells / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D050862:Oxidoreductases Acting on Sulfur Group Donors
chemical_list: D051546:Cyclooxygenase 2; D011506:Proteins; C088825:GFER protein, rat; D050862:Oxidoreductases Acting on Sulfur Group Donors