[Aldosterone: the mechanisms of molecular action].
Aldosterone: a steroid hormone of adrenal cortex, has recently attracted much interest not only due to its great importance in regulation of salt and water balance, but also because of its key role in therapy of cardiovascular and renal pathology. The classical genomic mechanism of molecular action of aldosterone is mediated through interaction with mineral-corticoid receptors. Fast nongenomic pathway of cell signal transduction begins with interaction with hypothetic membrane receptors and includes activation of different kinase cascades. Interference of these two pathways of signal transduction assures abroad spectrum of aldosterone effects depending on the cell type, and also secures multycomponent regulation depending on the need of specific functional and stress situation. This review is dedicated to modern views of mechanisms of aldosterone molecular action, mostly of the level of aldosterone-sensitive segment of kidney nephron.
Logvinenko
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D000450:Aldosterone / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000502:physiology; D018161:Receptors, Mineralocorticoid / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D015222:Sodium Channels / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000502:physiology
D018161:Receptors, Mineralocorticoid; D015222:Sodium Channels; D000450:Aldosterone