title: c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy.
abstract: Human breast cancer cell line SKBR3 expresses high level of the ErbB2 molecule, which has been associated with poor prognosis of breast cancer. Elevated ErbB2 functions as a transactivating co-receptor and promotes the formation of ErbB2 containing heterodimers, which are more mitogenic and transforming, and have a higher ligand affinity and signaling potency by virtue of the potent latent kinase activity of ErbB2. Interestingly, SKBR3 cells are non-tumorigenic in nude mice. By ectopic overexpression of c-Jun in SKBR3 cells, involvement of c-Jun in invasiveness and metastasis in vivo was investigated in this study. The critical role of c-Jun in the tumorigenesis and metastasis is demonstrated in nude mice.
authors.affiliation: Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Pu
authors.forename: Ming
authors.initials: M
authors.lastname: Shi
authors.forename: Liyong
authors.initials: L
authors.lastname: Chen
authors.forename: Lu
authors.initials: L
authors.lastname: Qian
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Song
authors.forename: Guogang
authors.initials: G
authors.lastname: Yuan
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Yu
authors.forename: Meiru
authors.initials: M
authors.lastname: Hu
authors.forename: Beifen
authors.initials: B
authors.lastname: Shen
authors.forename: Ning
authors.initials: N
authors.lastname: Guo
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D010641:Phenotype; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D014183:Transplantation, Heterologous
chemical_list: D016755:Proto-Oncogene Proteins c-jun