Metabolic syndrome traits in long-term survivors of pediatric sarcoma.
OBJECTIVE
The metabolic syndrome (MS), a cluster of central obesity, dyslipidemia, hyperglycemia, and hypertension, conveys an increased risk of type 2 diabetes and cardiovascular disease. This cross-sectional study investigated the prevalence of metabolic syndrome traits (MST) in long-term survivors of pediatric sarcoma (SARC) who received multi-modality therapy (MMT).


METHODS
Thirty-two SARC survivors (predominantly Ewings; median age 36.5; median age at MMT 15) underwent body composition, activity, and psychosocial analysis. Serum endocrine and inflammatory parameters and urine beta(2)-microglobulin (B2M) were evaluated. The prevalence of MST was compared to age- and gender-matched U.S. population data.


RESULTS
SARC survivors were more likely to have two or more MST (OR 2.38 95% CI: [1.14, 5.04]). Analysis of individual MST demonstrated higher prevalence of hypertension (OR 2.61 95% CI: [1.20, 5.59]), hypertriglyceridemia (OR 3.63 95% CI: [1.75, 7.60]), and male visceral abdominal obesity (20-39 years old OR 4.63 95% CI: [0.91, 21.63], 40-59 years old OR infinity). Survivors 18-39 years old had a higher prevalence of the MS (OR 4.29 95% CI: [1.50, 11.21]), defined as three or more MST. Plasminogen activator inhibitory activity (P = 0.016) and B2M (P = 0.027) increased with increasing numbers of MST. In males, total testosterone declined (P = 0.0027) as the number of MST increased. Average (P = 0.014) and maximum (P = 0.021) activity levels decreased as the number of MST increased.


CONCLUSIONS
After a median follow up of 17 years, adult SARC survivors of MMT had an increased prevalence of MST, especially those less than 40 years old. The development of MST in this population was associated with decreased testosterone and activity levels.
Hoffman
Karen E
KE
Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Derdak
Joanne
J
Bernstein
Donna
D
Reynolds
James C
JC
Avila
Nilo A
NA
Gerber
Lynn
L
Steinberg
Seth M
SM
Chrousos
George
G
Mackall
Crystal L
CL
Mansky
Patrick J
PJ
D000293:Adolescent; D000328:Adult; D001823:Body Composition; D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology / Q000523:psychology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism* / Q000473:pathology / Q000523:psychology; D012509:Sarcoma / Q000378:metabolism* / Q000473:pathology / Q000523:psychology; D012512:Sarcoma, Ewing / Q000378:metabolism / Q000473:pathology / Q000523:psychology