title: A randomised controlled trial comparing Triadcortyl with 10% glycerine-ichthammol in the initial treatment of severe acute otitis externa.
abstract: Acute otitis externa is a common clinical condition accounting for a large proportion of patients attending the otolaryngology department, although milder cases are often managed in primary care. Treatment of the most severe forms of otitis externa involves aural toilet, followed by the application of a topical preparation, commonly in the form of an ear canal dressing. A prospective single-blind randomized controlled trial was performed to compare the efficacy of 10% glycerine-ichthammol (GI) solution and Triadcortyl (TAC) ointment, both applied as ear canal dressings, in the initial management of severe acute otitis externa. A total of 64 patients were studied. Both treatment modalities were proven efficacious in the treatment of severe acute otitis externa. Although there was a statistically significant improvement of pain parameters in the TAC group, we found no significant differences in clinical findings between the two groups. Therefore, it is recommended that GI dressing can be used instead of an antibiotic dressing as an initial treatment of severe acute otitis externa on the basis of cost, avoidance of resistance and toxicity.
authors.affiliation: Department of Otolaryngology, Associated teaching hospital of the University of London, Luton and Dunstable Hospital, Lewsey Road, Luton, LU4 0DZ, UK. dramasood@yahoo.co.uk
authors.forename: Ajmal
authors.initials: A
authors.lastname: Masood
authors.forename: Ioannis
authors.initials: I
authors.lastname: Moumoulidis
authors.forename: Shalina
authors.initials: S
authors.lastname: Ray
authors.forename: Om
authors.initials: O
authors.lastname: Chawla
authors.forename: Jaan
authors.initials: J
authors.lastname: Panesar
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D005990:Glycerol / Q000008:administration & dosage; D006096:Gramicidin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000008:administration & dosage*; D009761:Nystatin / Q000008:administration & dosage*; D010032:Otitis Externa / Q000188:drug therapy*; D010147:Pain Measurement; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage*; D012997:Solvents / Q000008:administration & dosage; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; C014118:Gramicidin, Neomycin Sulfate, Nystatin, Triamcinolone Acetonide Drug Combination; D000644:Quaternary Ammonium Compounds; D012997:Solvents; D009761:Nystatin; D006096:Gramicidin; D014222:Triamcinolone Acetonide; D009355:Neomycin; C089399:ichthammol; D005990:Glycerol