Serum carboxy-terminal propeptide of type I procollagen (PIP) is a marker of diastolic dysfunction in patients with early type 2 diabetes mellitus.
This study was designed to investigate whether the serum concentration of the carboxy-terminal propeptide of procollagen type I (PIP), a marker of myocardial fibrosis, is related to changes of the ventricular filling dynamics in patients with early type 2 diabetes mellitus (T2DM). The T2DM group had lower mitral and tricuspid E/A ratios than the control group. Serum PIP was higher in patients with T2DM than in controls (131.1+/-45.6 vs. 109.3+/-32.5 ng/mL, p=0.039). A-Ar, an estimate of passive diastolic function, was inversely related to serum PIP levels in T2DM (r=-0.42, p=0.03). These results show a relation between LV diastolic function and serum PIP levels in early T2DM.
Ihm
Sang-Hyun
SH
Youn
Ho-Joong
HJ
Shin
Dong-Il
DI
Jang
Sung-Won
SW
Park
Chul-Soo
CS
Kim
Pum Joon
PJ
Kim
Hee-Yeol
HY
Chang
Kiyuk
K
Seung
Ki-Bae
KB
Kim
Jae-Hyung
JH
Choi
Kyu-Bo
KB
D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D006801:Humans; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000150:complications / Q000175:diagnosis
D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C042813:procollagen type I carboxy terminal peptide