title: Advanced small cell carcinoma of the ovary in a seventeen-year-old female, successfully treated with surgery and multi-agent chemotherapy.
abstract: Advanced small cell carcinoma of the ovary (FIGO stage III or IV) is a rare and usually lethal tumor seen in adolescents and young women. In pediatric patients with advanced disease, there have been only two case reports of successful therapy, we report a third patient, diagnosed at 17 years of age, with an abdominal mass and metastatic disease to regional and distant lymph nodes, who was successfully treated with surgery and intensive multi-agent chemotherapy. Imatinib, thalidomide, and celecoxib were also administered for up to 24 months following initial chemotherapy. She remains in remission 3 years from diagnosis.
authors.affiliation: Department of Pediatrics, Albany Medical Center, Albany, New York, USA. kanwarv@mail.amc.edu
authors.forename: Vikramjit S
authors.initials: VS
authors.lastname: Kanwar
authors.forename: Jessica
authors.initials: J
authors.lastname: Heath
authors.forename: Carolyn N
authors.initials: CN
authors.lastname: Krasner
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Pearce
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001549:Benzamides; D001761:Bleomycin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D000068579:Celecoxib; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D010879:Piperazines / Q000008:administration & dosage; D011720:Pyrazoles / Q000008:administration & dosage; D011743:Pyrimidines / Q000008:administration & dosage; D013449:Sulfonamides / Q000008:administration & dosage; D013792:Thalidomide / Q000008:administration & dosage; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D001549:Benzamides; D010879:Piperazines; D011720:Pyrazoles; D011743:Pyrimidines; D013449:Sulfonamides; D001761:Bleomycin; D013792:Thalidomide; D014747:Vinblastine; D005047:Etoposide; D004317:Doxorubicin; D000068877:Imatinib Mesylate; D003520:Cyclophosphamide; D000068579:Celecoxib