title: Ser128Arg E-selectin and Thr715Pro P-selectin polymorphisms and severe preeclampsia.
abstract: OBJECTIVE
  To investigate the association of functional E and P selectin polymorphisms with severe preeclampsia.
  
  
  METHODS
  P-selectin Thr715Pro and E-selectin Serl28Arg polymorphism were determined with the polymerase chain reaction in 126 women with severe preeclampsia and in 106 healthy pregnant women. Genotype distribution and allele prevalence of both groups were compared. Regression analysis was used to analyze the association between disease characteristics and genotype.
  
  
  RESULTS
  Genotype distributions and the allele prevalence were similar in the tested populations. Furthermore, the genotypes investigated had no impact on the risk of eclampsia of the hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. Multiple linear regression analysis identified the P-selectin 715Pro allele as an independent determinant of the time of onset of hypertension (p = 0.034) along with maternal age, smoking and body mass index before pregnancy.
  
  
  CONCLUSIONS
  The polymorphisms tested are not associated with the risk of severe preeclampsia.
authors.affiliation: 1st Department of Pediatrics, Semmelweis University, Budapest, Hungary. derla@gyer1.sote.hu
authors.forename: László
authors.initials: L
authors.lastname: Derzbach
authors.forename: Adám
authors.initials: A
authors.lastname: Balogh
authors.forename: Géza
authors.initials: G
authors.lastname: Bokodi
authors.forename: Barna
authors.initials: B
authors.lastname: Vásárhelyi
authors.forename: János
authors.initials: J
authors.lastname: Rigó
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D019040:E-Selectin / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D017359:HELLP Syndrome / Q000235:genetics*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D019007:P-Selectin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D015995:Prevalence; D011446:Prospective Studies
chemical_list: D019040:E-Selectin; D019007:P-Selectin