[Prevalence of Staphylococcus aureus nasal colonization in injection drug users].
A prevalence study was conducted to evaluate Staphylococcus aureus nasal colonization in two groups of injection drug users recruited at two drug addiction treatment centres in Rome and Frosinone (Italy). Prevalence of Staphylococcus aureus nasal colonization in the 181 subjects included in the study was 8.83%. Significantly increased carriage rates were found among drug users in Frosinone with respect to those in Rome. No other significant determinants of colonization were identified through multiple logistic regression analysis. Only 2 of 16 Staphylococcus aureus strains (12.5%) were found to be methicillin resistant. Genomic DNA restriction pattern analysis, through SmaI digestion and pulsed field gel electrophoresis, demonstrated wide genetic heterogeneity among the isolates. Although the great majority of PFGE patterns were found in single isolates, in some cases common patterns were identified in isolates obtained from different drug users, clearly indicating the possibility of interhuman transmission of Staphylococcus aureus in this population.
Tufi
Daniela
D
Sezione di Medicina Clinica e Sanità Pubblica, Dipartimento di Medicina Sperimentale, Sapienza Università di Roma.
De Vito
Corrado
C
Furnari
Giacomo
G
Marzuillo
Carolina
C
Anastasi
Daniela
D
Villari
Paolo
P
D000328:Adult; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D016521:Electrophoresis, Gel, Pulsed-Field / Q000379:methods; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015999:Multivariate Analysis; D009297:Nasal Mucosa / Q000382:microbiology*; D015995:Prevalence; D012044:Regression Analysis; D012384:Rome / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000209:etiology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D015819:Substance Abuse, Intravenous / Q000150:complications*