title: Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells.
abstract: BACKGROUND
  The rapidly growing field of targeted tumor therapy often utilizes an antibody, sometimes tagged with a tumor-ablating material such as radioisotope, directed against a specific molecule.
  
  
  RESULTS
  This report describes the discovery of nine novel decapeptides which can be radioactively labeled, bind to, and deliver (32)P to colon cancer cells. The decapeptides vary from one another by one to three amino acids and demonstrate vastly different binding abilities. The most avidly binding decapeptide can permanently deliver very high levels of radioisotope to the adenocarcinoma cancer cell lines at an efficiency 35 to 150 times greater than to a variety of other cell types, including cell lines derived from other types of cancer or from normal tissue.
  
  
  CONCLUSIONS
  This experimental approach represents a new example of a strategy, termed peptide binding therapy, for the potential treatment of colorectal and other adenocarcinomas.
authors.affiliation: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. jabrah14@jhmi.edu
authors.forename: John M
authors.initials: JM
authors.lastname: Abraham
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Sato
authors.forename: Yulan
authors.initials: Y
authors.lastname: Cheng
authors.forename: Bogdan
authors.initials: B
authors.lastname: Paun
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Kan
authors.forename: Alexandru
authors.initials: A
authors.lastname: Olaru
authors.forename: Zhe
authors.initials: Z
authors.lastname: Jin
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Rachana
authors.initials: R
authors.lastname: Agarwal
authors.forename: Stefan
authors.initials: S
authors.lastname: David
authors.forename: James P
authors.initials: JP
authors.lastname: Hamilton
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ito
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Mori
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Meltzer
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy*; D018938:Caco-2 Cells; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008495:Medical Oncology / Q000379:methods; D010455:Peptides / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage*; D011485:Protein Binding; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D010455:Peptides; D004364:Pharmaceutical Preparations; D010761:Phosphorus Radioisotopes