title: Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity.
abstract: Two new diarylheptanoids (1, 2), together with two known analogs (3, 4), were isolated from the rhizomes of Alpinia officinarum. The new compounds were elucidated to be (5S)-5-hydroxy-7-(3, 4-dihydroxyphenyl)-1-phenyl-3-heptanone (1) and (5R)-5-hydroxy-7-(3-methoxy-4, 5-dihydroxyphenyl)-1-phenyl-3-heptanone (2) based on their spectral analysis. Compound 4 showed moderate cytotoxicity against human tumor cell lines, HepG2, MCF-7 and SF-268, while no significant effect were found for compounds 1-3.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China. zhongmeizou@hotmail.com
authors.forename: Ning
authors.initials: N
authors.lastname: An
authors.forename: Zhong-mei
authors.initials: ZM
authors.lastname: Zou
authors.forename: Ze
authors.initials: Z
authors.lastname: Tian
authors.forename: Xiu-zhen
authors.initials: XZ
authors.lastname: Luo
authors.forename: Shi-lin
authors.initials: SL
authors.lastname: Yang
authors.forename: Li-zhen
authors.initials: LZ
authors.lastname: Xu
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D045744:Cell Line, Tumor; D036381:Diarylheptanoids / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D005909:Glioblastoma / Q000188:drug therapy; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000627:therapeutic use*; D027343:Rhizome
chemical_list: C539193:(5R)-5-hydroxy-7-(3-methoxy-4, 5-dihydroxyphenyl)-1-phenyl-3-heptanone; C539192:(5S)-5-hydroxy-7-(3, 4-dihydroxyphenyl)-1-phenyl-3-heptanone; D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids; D010936:Plant Extracts