title: A case of Castleman's disease associated with diffuse idiopathic skeletal hyperostosis and ossification of the posterior longitudinal ligament of the spine.
abstract: Castleman's disease (CD), diffuse idiopathic skeletal hyperostosis (DISH), and ossification of the posterior longitudinal ligament of the spine (OPLL) are three different entities. Castleman's disease displaying a variety of calcifications in the abdomen and/or pelvis has been reported in some papers. However, there were no reports suggesting an association between CD and ossification/calcification in spine and joints. So far, there has been no case report regarding the coexistence of these diseases in the literature. Herein, we detail a 75-year-old man suffering from CD who demonstrated the features of DISH with coexisting features of OPLL. The cardinal symptoms such as fatigue, high fever, and swollen glands in this case were reduced by corticosteroid therapy. However, it is possible to produce actual symptoms of ossifying/calcified diathesis of entheses and ligaments as a consequence, like the pathology of calcification found in the region of the spleen. In this paper, we describe this patient in order to discuss the association of these diseases.
authors.affiliation: Department of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada, Shinjuku-ku, Tokyo, 162-0054, Japan.
authors.forename: Shu
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Momohara
authors.forename: Katsunori
authors.initials: K
authors.lastname: Ikari
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mochizuki
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kawamura
authors.forename: So
authors.initials: S
authors.lastname: Tsukahara
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Nishimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okamoto
authors.forename: Taisuke
authors.initials: T
authors.lastname: Tomatsu
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis*; D015897:Comorbidity; D003937:Diagnosis, Differential; D006801:Humans; D004057:Hyperostosis, Diffuse Idiopathic Skeletal / Q000150:complications / Q000175:diagnosis*; D007719:Knee Joint / Q000000981:diagnostic imaging; D017846:Longitudinal Ligaments / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D017887:Ossification of Posterior Longitudinal Ligament / Q000150:complications / Q000175:diagnosis*; D054850:Osteophyte / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome