title: Exploring the flap pocket of the antimalarial target plasmepsin II: the "55 % rule" applied to enzymes.
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
authors.forename: Martina
authors.initials: M
authors.lastname: Zürcher
authors.forename: Thomas
authors.initials: T
authors.lastname: Gottschalk
authors.forename: Solange
authors.initials: S
authors.lastname: Meyer
authors.forename: Daniel
authors.initials: D
authors.lastname: Bur
authors.forename: François
authors.initials: F
authors.lastname: Diederich
mesh_terms: D000465:Algorithms; D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D001665:Binding Sites; D015195:Drug Design; D020128:Inhibitory Concentration 50; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D015800:Protozoan Proteins; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D011480:Protease Inhibitors; D015800:Protozoan Proteins; D016282:Aspartic Acid Endopeptidases; C100637:plasmepsin II