The MnSOD Val9Ala polymorphism, dietary antioxidant intake, risk and survival in ovarian cancer (Australia).
OBJECTIVE
We assessed the MnSOD Val9Ala polymorphism and its interaction with dietary antioxidant intake in ovarian cancer risk and survival.


METHODS
The MnSOD polymorphism was assessed in 543 ovarian cancer cases and 1130 controls. We used regression analysis to model the association between genotype and risk, case-only analyses to estimate risk modification by dietary variables, and proportional hazard models for survival analysis.


RESULTS
We found no association between this polymorphism and ovarian cancer risk or survival, nor was there evidence of any interaction with dietary antioxidant intake.


CONCLUSIONS
The Val9Ala MnSOD polymorphism does not influence ovarian cancer risk or survival.
Johnatty
Sharon E
SE
Queensland Institute of Medical Research, Brisbane, P.O. Royal Brisbane Hospital, Herston, QLD 4029, Australia.
Nagle
Christina M
CM
Spurdle
Amanda B
AB
Chen
Xiaoqing
X
Webb
Penelope M
PM
Chenevix-Trench
Georgia
G
D000328:Adult; D000409:Alanine / Q000235:genetics; D000975:Antioxidants / Q000008:administration & dosage*; D001315:Australia; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism; D014633:Valine / Q000235:genetics
D000975:Antioxidants; D013482:Superoxide Dismutase; D014633:Valine; D000409:Alanine