Understanding the role of LH: myths and facts.
This review summarizes a series of lectures given at a recent Continuing Medical Education meeting in Hamburg, Germany (May 2007), aiming to understand the role of luteinizing hormone (LH) in follicular development during the natural menstrual cycle and controlled ovarian stimulation. Clinical situations and target groups of patients who might benefit from LH supplementation during their ovarian stimulation were discussed and defined. The lectures updated knowledge on the physiology of LH during the normal menstrual cycle and the role of LH in ovarian stimulation. The concept of the 'LH window' was presented, and the use of LH supplementation in different groups of patients undergoing controlled ovarian stimulation was discussed, including those with advanced age, hypogonadotrophic hypogonadism, pituitary down-regulation and poor response. In addition, the different ways of using LH or human chorionic gonadotrophin supplementation in ovulation induction protocols were described.
Fischer
Robert
R
Hamburg Fertility Centre, Hamburg, Germany. rfischer@kinderwunsch-hamburg.de
D005260:Female; D005858:Germany; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D008597:Menstrual Cycle / Q000378:metabolism; D006080:Ovarian Follicle / Q000187:drug effects / Q000254:growth & development*; D010062:Ovulation Induction
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone