title: [Polymorphism of the human platelet alloantigens HPA-3 and HPA-9w in the Chinese Han population].
abstract: OBJECTIVE
  To study the polymorphism of human platelet alloantigens HPA-3 and HPA-9w in the Chinese Han population.
  
  
  METHODS
  A total of 1000 unrelated Chinese Han blood donors from different provinces of China were genotyped for HPA-3 and HPA-9w using PCR-sequence specific primer assay.
  
  
  RESULTS
  Gene frequencies of 1000 Chinese Hans for HPA-3a and HPA-3b were 0.5935 and 0.4065 respectively, and all of them were HPA-9a positive. The distributions of HPA-3, HPA-9w of Chinese Hans which detected by chi-square criterion fit Hardy-Weinberg equilibrium. There were significant differences of the HPA-3 alleles gene frequency between Guangdong province and other five investigated provinces which included Shanxi, Heilongjiang, Zhejiang, Yunnan and Jiangsu. In comparison to other ethnic groups, no significant differences were observed in the distributions of HPA-3 except the Vietnamese and Australian.
  
  
  CONCLUSIONS
  The results show that the chance of HPA-3 incompatibility were 0.3661 in random transfusion, and also provide a basis for researching on alloimmune thrombocytopenia and HPA-matched transfusion.
authors.affiliation: Shanghai Blood Center, Shanghai, 200051 P.R. China. fengmL@sh163.net.
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.forename: Ming-liang
authors.initials: ML
authors.lastname: Feng
authors.forename: Tong
authors.initials: T
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
authors.forename: Biao
authors.initials: B
authors.lastname: Yin
authors.forename: Da-zhuang
authors.initials: DZ
authors.lastname: Liu
mesh_terms: D000483:Alleles; D016824:Antigens, Human Platelet / Q000235:genetics* / Q000276:immunology; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D004247:DNA / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006648:Histocompatibility / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D016824:Antigens, Human Platelet; D004247:DNA