Health implications of antimicrobial resistance for patients with acute kidney injury and bloodstream infection.
Studies have produced conflicting findings on outcomes for patients with antimicrobial-resistant infection. This study evaluated whether infection with an antimicrobial-resistant organism affects outcome in critically ill patients with acute kidney injury treated with renal replacement therapy and whose clinical course is complicated with a nosocomial bloodstream infection. We found that infection with an antimicrobial-resistant organism did not adversely affect clinical outcome in this specific cohort, which already has a high mortality rate.
Hoste
Eric A J
EA
Intensive Care Department, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Eric.Hoste@UGent.be
Vandijck
Dominique M
DM
Vanholder
Raymond C
RC
De Waele
Jan J
JJ
Lameire
Norbert H
NH
Claus
Stefaan
S
De Schuijmer
Johan
J
Dhondt
Annemieke W
AW
Decruyenaere
Johan M A
JM
Verschraegen
Gerda
G
Blot
Stijn I
SI
D058186:Acute Kidney Injury / Q000150:complications* / Q000628:therapy; D000368:Aged; D016470:Bacteremia / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D001530:Belgium / Q000453:epidemiology; D015331:Cohort Studies; D003428:Cross Infection / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D017582:Renal Replacement Therapy