The influence of experimental desynchronosis on the morphofunctional characteristics of mouse immune system.
The aim of this study is to investigate the influence of experimental desynchronosis on the immune system and estimate benzo[a]pyrene (BP) influence on the immune reactivity of mice under the condition of desyncronosis (DS) in comparison with intact organisms. Mice (CBA X C57BL)F1 were kept under constant light during two weeks and natural alternation of darkness and light (control group). Animals of the two groups received benzo[a]pyrene solution in olive oil. The existence of diurnal variation of cell populations of lymphoid organs and blood, humoral immune response to SRBC were revealed. Changes of diurnal dynamics of these parameters and decrease of humoral immune response to SRBC have been observed in animals kept under constant light in comparison with animals kept under standard light conditions. It is likely to indicate the development of internal DS. BP influenced the cellular composition and immune response of intact and DS animals in a different way. So, the changes of light regime lead to development of the internal DS of immune system that influenced its functional capacity and sensitivity to damaging effect of chemical ecological factor.
Trufakin
V A
VA
Institute of Physiology, Institute of Clinical and Experimental Lymphology SB RAMS, Novosibirsk, Russia.
Shurlygina
A V
AV
Michurina
S V
SV
Verbitskaja
L V
LV
Litvinenko
G I
GI
Kovshik
I G
IG
Panteleeva
N G
NG
Melnikova
E V
EV
Bitchaeva
M V
MV
D000818:Animals; D001564:Benzo(a)pyrene / Q000009:adverse effects / Q000633:toxicity*; D021081:Chronobiology Disorders / Q000139:chemically induced* / Q000276:immunology; D002940:Circadian Rhythm; D003624:Darkness; D007107:Immune System / Q000187:drug effects / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D015213:Neuroimmunomodulation; D013997:Time Factors
D007166:Immunosuppressive Agents; D001564:Benzo(a)pyrene