Gene dynamics and nuclear architecture during differentiation.
Recent advances have demonstrated that placing genes in a specific nuclear context plays an important role in the regulation of coordinated gene expression, thus adding an additional level of complexity to the mechanisms of gene regulation. Differentiation processes are characterized by dynamic changes in gene activation and silencing. These alterations are often accompanied by gene relocations in relation to other genomic regions or to nuclear compartments. Unraveling of mechanisms and dynamics of chromatin positioning will thus expand our knowledge about cellular differentiation.
Schöfer
Christian
C
Center for Anatomy and Cell Biology, Medical University of Vienna, Schwarzspanierstr. 17, 1090 Vienna, Austria. christian.schoefer@meduniwien.ac.at
Weipoltshammer
Klara
K
D000818:Animals; D001665:Binding Sites / Q000235:genetics; D001692:Biological Transport / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics*; D002467:Cell Nucleus / Q000235:genetics* / Q000378:metabolism / Q000648:ultrastructure*; D042002:Chromatin Assembly and Disassembly; D004330:Drosophila / Q000166:cytology / Q000235:genetics; D022041:Euchromatin / Q000378:metabolism; D005786:Gene Expression Regulation; D023061:Gene Order; D006570:Heterochromatin / Q000378:metabolism; D006801:Humans; D015530:Nuclear Matrix / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D013997:Time Factors; D015533:Transcriptional Activation; D015003:Yeasts / Q000166:cytology / Q000235:genetics
D022041:Euchromatin; D006570:Heterochromatin