title: Retreatment of chronic hepatitis C in previous non-responders and relapsers.
abstract: Therapy for chronic hepatitis C has improved dramatically over the past 20 years. Unfortunately, approximately 50% of those treated do not have a durable response to therapy. Non-responders and relapsers after previous interferon-based therapy are particularly challenging with regard to clinical management. This article provides a general overview of the treatment of hepatitis C and reviews present data regarding management of patients with chronic hepatitis C who are non-responders or relapsers after previous treatment. The review ends with the authors' opinion regarding present management of non-responders and relapsers and future emerging therapies.
authors.affiliation: Center for Liver Diseases, University of Chicago, Section of Gastroenterology, 5841 S. Maryland, MC7120, Chicago, IL 60637, USA.
authors.forename: Rohit
authors.initials: R
authors.lastname: Satoskar
authors.forename: Donald M
authors.initials: DM
authors.lastname: Jensen
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage*; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000517:prevention & control / Q000821:virology; D006801:Humans; D019233:Retreatment; D055502:Secondary Prevention; D017211:Treatment Failure
chemical_list: D000998:Antiviral Agents