title: An assessment of the association of bispectral index with 2 clinical sedation scales for monitoring depth of procedural sedation.
abstract: OBJECTIVE
  We conducted a study to assess the correlation of bispectral index (BIS) to 2 clinical sedation scales.
  
  
  METHODS
  This was a prospective, observational study. The BIS number was recorded at baseline and every 30 seconds. One investigator separately monitored the patients for depth of sedation using the Observer's Assessment of Alertness/Sedation and the Continuum of Depth of Sedation scales.
  
  
  RESULTS
  During the 6-month period, 75 patients were enrolled. The Spearman correlation between the BIS and the Observer's Assessment of Alertness/Sedation was 0.59 (95% confidence interval [CI], 0.44-0.74). The Spearman correlation between the BIS and the Continuum of Depth of Sedation was 0.53 (95% CI, 0.36-0.70). The mean minimum BIS for patients without a complication was 70 (SD, 15.9) compared with 68 (SD, 12.9) for patients with a complication (difference = 2; 95% CI, -7-11).
  
  
  CONCLUSIONS
  Our study demonstrated moderate correlation between BIS and the 2 clinical sedation scales. The correlation is not strong enough to be used reliably in a clinical setting. The mean minimum BIS scores were not significantly different for those with sedation complications vs those without complications.
authors.affiliation: Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. chsweave@iupui.edu
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Weaver
authors.forename: William H
authors.initials: WH
authors.lastname: Hauter
authors.forename: Cory E
authors.initials: CE
authors.lastname: Duncan
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Brizendine
authors.forename: William H
authors.initials: WH
authors.lastname: Cordell
mesh_terms: D016292:Procedural Sedation; D004569:Electroencephalography; D006801:Humans; D006993:Hypnotics and Sedatives; D008991:Monitoring, Physiologic / Q000379:methods*; D019370:Observation; D015742:Propofol; D011446:Prospective Studies; D012815:Signal Processing, Computer-Assisted; D014193:Trauma Centers
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol