title: Importance of the Debye screening length on nanowire field effect transistor sensors.
abstract: Nanowire field effect transistors (NW-FETs) can serve as ultrasensitive detectors for label-free reagents. The NW-FET sensing mechanism assumes a controlled modification in the local channel electric field created by the binding of charged molecules to the nanowire surface. Careful control of the solution Debye length is critical for unambiguous selective detection of macromolecules. Here we show the appropriate conditions under which the selective binding of macromolecules is accurately sensed with NW-FET sensors.
authors.affiliation: Department of Biomedical Engineering, Yale University, PO Box 208284, New Haven, Connecticut 06520, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Stern
authors.forename: Robin
authors.initials: R
authors.lastname: Wagner
authors.forename: Fred J
authors.initials: FJ
authors.lastname: Sigworth
authors.forename: Ronald
authors.initials: R
authors.lastname: Breaker
authors.forename: Tarek M
authors.initials: TM
authors.lastname: Fahmy
authors.forename: Mark A
authors.initials: MA
authors.lastname: Reed
mesh_terms: D015374:Biosensing Techniques; D001709:Biotechnology / Q000379:methods*; D004247:DNA / Q000737:chemistry; D004277:DNA, Single-Stranded / Q000737:chemistry; D008027:Light; D046911:Macromolecular Substances / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D015233:Models, Statistical; D008968:Molecular Conformation; D036103:Nanotechnology / Q000379:methods*; D053770:Nanowires / Q000737:chemistry; D019809:Streptavidin / Q000737:chemistry; D013696:Temperature; D014173:Transistors, Electronic
chemical_list: D004277:DNA, Single-Stranded; D046911:Macromolecular Substances; D004247:DNA; D019809:Streptavidin