Radiation-induced antitumor properties of vitamin B5 (pantothenic acid) and its effect on mitomycin C activity: experiments in vitro.
Vitamin B5 (pantothenic acid) shows a strongly pronounced antitumor effect under the influence of ionizing radiation. In the frame of experiments in vitro (model: Escherichia coli bacteria, AB1157) performed under the exact knowledge of concentration and kind of the free radicals acting in the various aqueous media (pH 7.4) the following was established: (i) vitamin B5 possesses a very intense antitumor property, (ii) it exerts a strong synergistic effect on mitomycin C (MMC), (iii) the oxidizing species (OH*, O2*-) appears to be most important in the initiation of the observed effect. The generated radiolytic products from vitamin B5 very likely also play an important role in this respect.
Schittl
Heike
H
Section Radiation Biology, Department of Nutrition Sciences, The University of Vienna, A-1090 Vienna, Austria.
Getoff
Nikola
N
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D005720:Gamma Rays; D016685:Mitomycin / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism; D010205:Pantothenic Acid / Q000737:chemistry / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism
D000970:Antineoplastic Agents; D005609:Free Radicals; D011838:Radiation-Sensitizing Agents; D017382:Reactive Oxygen Species; D010205:Pantothenic Acid; D016685:Mitomycin; D010100:Oxygen