Phospho-regulation of Beta-catenin adhesion and signaling functions.
Beta-catenin plays a critical structural role in cadherin-based adhesions and is also an essential co-activator of Wnt-mediated gene expression. The degree to which beta-catenin participates in these two functions is dictated by the availability of beta-catenin binding partners, and an emerging theme is that these binding interactions are regulated by phosphorylation. Inputs from various cell-signaling events can therefore impact beta-catenin function, which may be necessary for the finely tuned adhesive and signaling responses required for tissue morphogenesis.
Daugherty
Rebecca Leadem
RL
The Integrated Graduate Program in the Life Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. c-gottardi@northwestern.edu
Gottardi
Cara J
CJ
D000818:Animals; D015820:Cadherins / Q000737:chemistry / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D010766:Phosphorylation; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs / Q000502:physiology; D015398:Signal Transduction; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism; D051153:Wnt Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051176:beta Catenin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D015820:Cadherins; D004268:DNA-Binding Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D051176:beta Catenin