Effects of different nutritional support on lung mechanics and remodelling in undernourished rats.
This study investigated the impact of three different oral nutritional support regimens on lung mechanics and remodelling in young undernourished Wistar rats. In the nutritionally deprived group, rats received one-third of their usual daily food consumption for 4 weeks. Undernourished rats were divided into three groups receiving a balanced, glutamine-supplemented, or long-chain triglyceride-supplemented diet for 4 weeks. In the two control groups, rats received food ad libitum for 4 (C4) or 8 weeks. Lung viscoelastic pressure and static elastance were higher in undernourished compared to C4 rats. After refeeding, lung mechanical data remained altered except for the glutamine-supplemented group. Undernutrition led to a reduced amount of elastic and collagen fibres in the alveolar septa. Elastic fibre content returned to control with balanced and glutamine-supplemented diets, but increased with long-chain triglyceride-supplemented diet. The amount of collagen fibre augmented independent of nutritional support. In conclusion, glutamine-supplemented diet is better at reducing morphofunctional changes than other diets after 4 weeks of refeeding.
Dias
Cristina M
CM
Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Ilha do Fundão, 21949-900 Rio de Janeiro, Brazil.
Pássaro
Caroline P
CP
Antunes
Mariana A
MA
Cagido
Viviane R
VR
Einicker-Lamas
Marcelo
M
Lowe
Jennifer
J
Negri
Elnara M
EM
Damaceno-Rodrigues
Nilsa R
NR
Soncini
Roseli
R
Capelozzi
Vera L
VL
Zin
Walter A
WA
Rocco
Patricia R M
PR
D000818:Animals; D015153:Blotting, Western; D001835:Body Weight / Q000502:physiology; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D003094:Collagen / Q000502:physiology; D004328:Drive; D004548:Elasticity; D005652:Functional Residual Capacity / Q000502:physiology; D005973:Glutamine / Q000494:pharmacology; D008055:Lipids / Q000737:chemistry; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D044342:Malnutrition / Q000178:diet therapy / Q000503:physiopathology*; D046529:Microscopy, Electron, Transmission; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D018529:Nutritional Support; D011506:Proteins / Q000737:chemistry; D011650:Pulmonary Alveoli / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D015656:Respiratory Mechanics / Q000502:physiology*; D012132:Respiratory Muscles / Q000187:drug effects / Q000503:physiopathology; D014280:Triglycerides / Q000494:pharmacology
D008055:Lipids; D011506:Proteins; D014280:Triglycerides; D005973:Glutamine; D003094:Collagen