Can circulated lung cancer cells pass to the urine without apparent urine tract metastases? A single centre series.
Urine cytology has been a useful tool for the diagnosis of urinary tract malignancies. However, the presence of tumor cells in the urine sediment without an obvious urothelial metastatic deposit is a rare phenomenon and in patients with lung cancer has never been reported. We present five cases with metastatic lung cancer and positive urine cytology. The possible mechanisms underlining this phenomenon and its implications are discussed.
Kamposioras
Konstantinos
K
Department of Medical Oncology, Ioannina University Hospital, Niarxou Avenue, 45500 Ioannina, Greece.
Pentheroudakis
George
G
Department of Medical Oncology, Ioannina University Hospital, Niarxou Avenue, 45500 Ioannina, Greece.
Malamou-Mitsi
Vassiliki
V
Department of Pathology-Cytopathology, Ioannina University Hospital, Ioannina, Greece.
Pappa
Lina
L
Department of Pathology-Cytopathology, Ioannina University Hospital, Ioannina, Greece.
Bafa
Maria
M
Department of Pathology-Cytopathology, Ioannina University Hospital, Ioannina, Greece.
Pavlidis
Nicholas
N
Department of Medical Oncology, Ioannina University Hospital, Niarxou Avenue, 45500 Ioannina, Greece. Electronic address: npavlid@cc.uoi.gr.
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000652:urine; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D014556:Urine / Q000166:cytology*; D014571:Urologic Neoplasms / Q000556:secondary*