Development of spontaneous seizures after experimental status epilepticus: implications for understanding epileptogenesis.
This report examines several concepts concerning the latent period to the first convulsive seizure, subsequent increases in seizure frequency, and possible mechanisms of epileptogenesis after kainate-induced status epilepticus. Previous data concerning the latent period and seizure progression from intermittent and continuous behavioral monitoring are compared, and hypothetical mechanisms of acquired epilepsy are discussed. Data involving electrographic recordings with tethered animals or with radiotelemetry are assessed in terms of their potential for addressing different hypotheses concerning the latent period and progressive changes in seizure frequency. Experimental analyses of the time course of occurrence of spontaneous seizures are interpreted in terms of possible cellular mechanisms underlying epileptogenesis.
Williams
Philip A
PA
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Hellier
Jennifer L
JL
White
Andrew M
AM
Staley
Kevin J
KJ
Dudek
F Edward
FE
D000818:Animals; D015415:Biomarkers; D001930:Brain Injuries / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000706:statistics & numerical data*; D006801:Humans; D007608:Kainic Acid; D008959:Models, Neurological; D008991:Monitoring, Physiologic; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology*; D013226:Status Epilepticus / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology*; D013686:Telemetry; D013997:Time Factors; D014743:Videotape Recording
D015415:Biomarkers; D007608:Kainic Acid