Pulmonary nodular lymphoid hyperplasia associated with Sjögren's syndrome.
Pulmonary nodular lymphoid hyperplasia (NLH) is a term first suggested by Kradin and Mark to describe one or more pulmonary nodules or localized lung infiltrates consisting of reactive lymphoid proliferation. To date, there have been only a few cases of pulmonary NLH reported associated with autoimmune disorders. There is no case of NLH associated with Sjögren's syndrome from Korea in the medical literature. A 56-year-old woman was referred to our hospital with cough productive of sputum and chest tightness. The Computed tomography scans of the chest revealed multiple and well-defined peribronchiolar nodular opacities. A video assisted thoracoscopic surgery (VATS) biopsy was performed and the nodular opacity in the lung parenchyma was pathologically confirmed as NLH. Through meticulous review of patient's record, we found that she had been suffering from dry eye and dry mouth. The symptoms suggested Sjögren's syndrome, which was confirmed by specific laboratory tests including the Schirmer test, anti-nuclear antibody and anti-Ro/La antibody. The patient is followed regularly and has no further progression of symptoms.
Song
Moo-Kon
MK
Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea.
Seol
Young-Mi
YM
Park
Young-Eun
YE
Kim
Yun-Seong
YS
Lee
Min-Ki
MK
Lee
Chang-Hun
CH
Jeong
Yeon-Ju
YJ
D001706:Biopsy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D019310:Pseudolymphoma / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000150:complications*; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed