title: Amiodarone-induced hepatitis and polyneuropathy.
abstract: Amiodarone chlorhydrate is a diiodated benzofuran derivative, and it is used to treat cardiac rhythm abnormalities. Hepatotoxicity is a relatively uncommon side effect of amiodarone, and symptomatic hepatic dysfunction occurs in fewer than 1% of the patients taking amiodarone. Cirrhosis is a rare complication that's been confirmed in 12 cases. Peripheral neuropathy occurs in 10% of patients taking aminodarone. We report here on an unusual case of amiodarone-induced hepatotoxicity and peripheral neurotoxicity. A 75 year old man with normal liver function was given amiodarone for treating his atrial fibrillation and heart failure. He developed nausea, vomiting, muscle weakness and wasting after 17.8 months therapy with amiodarone (400 mg orally once per day). Liver biopsy showed the presence of foam cells in the hepatic sinusoids and Mallory bodies in the periportal hepatocytes on light microscopy. Sural nerve biopsy showed demyelination, and nerve conduction studies showed mixed sensorimotor polyneuropathy. These observations show the necessity of monitoring the hepatic function and conducting neurologic examination of the patients treated with amiodarone.
authors.affiliation: Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
authors.forename: Hyun Mo
authors.initials: HM
authors.lastname: Kang
authors.forename: Yoon Sae
authors.initials: YS
authors.lastname: Kang
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Jae Kyu
authors.initials: JK
authors.lastname: Seong
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Kang
authors.forename: Heon Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Byung Seok
authors.initials: BS
authors.lastname: Lee
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000139:chemically induced; D008297:Male; D011115:Polyneuropathies / Q000139:chemically induced*
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone