title: Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma.
abstract: A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA. brennera@mail.nih.gov
authors.forename: A V
authors.initials: AV
authors.lastname: Brenner
authors.forename: M A
authors.initials: MA
authors.lastname: Butler
authors.forename: S S
authors.initials: SS
authors.lastname: Wang
authors.forename: A M
authors.initials: AM
authors.lastname: Ruder
authors.forename: N
authors.initials: N
authors.lastname: Rothman
authors.forename: P A
authors.initials: PA
authors.lastname: Schulte
authors.forename: S J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: H A
authors.initials: HA
authors.lastname: Fine
authors.forename: M S
authors.initials: MS
authors.lastname: Linet
authors.forename: P D
authors.initials: PD
authors.lastname: Inskip
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D016207:Cytokines / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D016207:Cytokines; D005819:Genetic Markers