title: [Mucosal lesions in the larynx: predictive value of new imaging modalities for a histological diagnosis].
abstract: BACKGROUND
  Optical coherence tomography (OCT) and high-frequency ultrasound are promising new methods in the early diagnosis of laryngeal cancer. However, no reliable values are given in the literature for epithelial thickness in early laryngeal cancer and its precursor lesions of the vocal folds.
  
  
  METHODS
  In the present study, epithelial thickness in different benign and malignant lesions of the vocal folds was determined histologically using a normal white light microscope.
  
  
  RESULTS
  The vocal fold mucosa showed progressive thickening over the different grades of dysplasia up to microinvasive carcinoma, while additional inflammation did not have any significant influence on the total epithelial thickness. In moderate dysplasia, however, the mean thickness of the epithelium was found to be double that of normal mucosa, and in severe dysplasia and carcinoma in situ, as much as three times that of normal mucosa. In the presence of microinvasive carcinoma, the average thickness of the epithelium was found to be as much as six times that in healthy mucosa. On the other hand, in case of benign lesions such as Reinke's edema, polyps, chronic laryngitis, and papillomas there was only slight epithelial thickening.
  
  
  CONCLUSIONS
  Determination of epithelial thickness by OCT or high-frequency ultrasound may allow conclusions on whether or not a laryngeal lesion is malignant.
authors.affiliation: Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Kantonsspital AG, Tellstrasse, CH-5001, Aarau, Schweiz. marcel.kraft@gmx.ch
authors.forename: M
authors.initials: M
authors.lastname: Kraft
authors.forename: K
authors.initials: K
authors.lastname: Lüerssen
authors.forename: H
authors.initials: H
authors.lastname: Lubatschowski
authors.forename: J
authors.initials: J
authors.lastname: Woenckhaus
authors.forename: S
authors.initials: S
authors.lastname: Schöberlein
authors.forename: H
authors.initials: H
authors.lastname: Glanz
authors.forename: C
authors.initials: C
authors.lastname: Arens
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007820:Laryngeal Mucosa / Q000000981:diagnostic imaging* / Q000473:pathology*; D007822:Laryngeal Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*