Carotid geometry effects on blood flow and on risk for vascular disease.
It has been widely observed that atherosclerotic diseases occur at sites with complex hemodynamics, such as artery bifurcations, junctions, and regions of high curvature. These regions usually have very low or highly oscillatory wall shear stress (WSS). In the present work, 3D pulsatile blood flow through a model of the carotid artery bifurcation was simulated using a finite volume numerical method. The goal was to quantify the risk of atherogenesis associated with different carotid artery geometries. A risk scale based on the average WSS on the sinus wall of the internal carotid artery was proposed-a scale that can be used to quantify the effect of the carotid geometry on the relative risk for developing vascular disease. It was found that the bifurcation angle and the out-of-plane angle of the internal carotid artery affect the formation of low stress regions on the carotid walls. The main conclusions are: (a) larger internal carotid artery angles (theta(IC)) generally increase the frequency and the area of blood recirculation and lower the WSS on the sinus wall, hence increasing the risk of plaque build-up; (b) off-plane angles were found to lower the WSS on the sinus for geometries with theta(IC)25 degrees . Larger off-plane angles generally increase the danger of plague build-up; (c) for theta(IC) < 25 degrees , the off-plane angle does not have an obvious effect on the hemodynamic WSS; (d) symmetric bifurcations were found to increase the WSS on the sinus wall and ease the risk of vascular disease.
Nguyen
Kien T
KT
School of Chemical, Biological and Materials Engineering, The University of Oklahoma, 100 East Boyd, SEC T-335, Norman, OK 73019, USA.
Clark
Christopher D
CD
Chancellor
Thomas J
TJ
Papavassiliou
Dimitrios V
DV
D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002339:Carotid Arteries / Q000033:anatomy & histology / Q000502:physiology*; D002340:Carotid Artery Diseases / Q000209:etiology / Q000503:physiopathology*; D016893:Carotid Stenosis / Q000209:etiology / Q000503:physiopathology*; D003198:Computer Simulation; D018056:Hemorheology; D006801:Humans; D008954:Models, Biological; D011673:Pulsatile Flow / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D012307:Risk Factors; D013314:Stress, Mechanical