title: Hepatitis C virus and risk of non-Hodgkin lymphoma in British Columbia, Canada.
abstract: We investigated Hepatitis C virus (HCV) seropositivity and the risk of non-Hodgkin lymphoma (NHL) in a population-based case-control study in British Columbia, Canada. Cases were aged 20-79, diagnosed between March 2000 and February 2004, and resident in greater Vancouver or Victoria. Cases with HIV or a prior transplant were excluded. Controls were chosen from the Client Registry of the British Columbia (BC) Ministry of Health, and were age/sex/region frequency matched to cases. Antibodies for HCV were measured in 795 cases and 697 control subjects. HCV seropositivity was 2.4% in cases and 0.7% in controls [odds ratio (OR) = 2.6, 95% confidence interval (CI) = 0.9-7.4]. A significantly elevated risk was observed for B-cell lymphoma (OR = 2.9, 95%CI = 1.0-8.6). The highest risks were associated with diffuse large B-cell lymphoma (OR = 7.3, 95%CI = 2.1-25.0) and marginal zone lymphoma (OR = 6.1, 95%CI = 1.1-33.9). Our results provide further evidence that HCV infection contributes to NHL risk.
authors.affiliation: BC Cancer Agency, Vancouver, British Columbia, Canada. jspinelli@bccrc.ca
authors.forename: John J
authors.initials: JJ
authors.lastname: Spinelli
authors.forename: Agnes S
authors.initials: AS
authors.lastname: Lai
authors.forename: Mel
authors.initials: M
authors.lastname: Krajden
authors.forename: Anton
authors.initials: A
authors.lastname: Andonov
authors.forename: Randy D
authors.initials: RD
authors.lastname: Gascoyne
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Connors
authors.forename: Angela R
authors.initials: AR
authors.lastname: Brooks-Wilson
authors.forename: Richard P
authors.initials: RP
authors.lastname: Gallagher
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D016174:Hepacivirus / Q000472:pathogenicity*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007124:Immunoenzyme Techniques; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D000914:Antibodies, Viral