Coronary vasoregulation in health and disease.
The present article reviews pertinent contributions from the Coronary Physiology Research Group at the Quebec Heart Institute to the understanding of coronary physiology in health and disease. Mechanisms that contribute to regulation of coronary blood flow and its distribution across the ventricular wall are discussed. Data from animal studies of ischemia-reperfusion injury are also presented and discussed in the context of current concepts regarding postischemic myocardial protection strategies. Future research directions regarding the cardiac nervous system and its importance in the regulation of coronary blood flow, cardiac function and myocyte injury during acute myocardial infarction are also discussed.
Kingma
John G
JG
Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie, Laval Hospital Hospital, Sainte-Foy, Quebec.
Rouleau
Jacques R
JR
D000818:Animals; D002318:Cardiovascular Diseases / Q000473:pathology / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000294:innervation* / Q000502:physiology; D004195:Disease Models, Animal; D006321:Heart / Q000294:innervation* / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans