Use of bone morphogenetic proteins for augmentation of bone regeneration.
A large body of preclinical and clinical data now documents that recombinant BMPs can be used for skeletal regeneration in humans and animals. Recombinant human BMP-2 and BMP-7 have been approved for use in human patients with long-bone fractures and nonunions and in patients undergoing lumbar fusion or various maxillofacial and dental regenerative procedures. These products have also been made available for veterinary use.
Kirker-Head
Carl A
CA
Orthopaedic Research Laboratory, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
Boudrieau
Randy J
RJ
Kraus
Karl H
KH
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods / Q000662:veterinary*; D002454:Cell Differentiation; D049109:Cell Proliferation; D017102:Fracture Healing / Q000187:drug effects / Q000502:physiology; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology*; D015398:Signal Transduction; D016211:Transforming Growth Factor alpha / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D016211:Transforming Growth Factor alpha