title: Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins.
abstract: A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.
authors.affiliation: Satoris, Inc., 2686 Middlefield Road, Suite E, Redwood City, California 94063, USA.
authors.forename: Sandip
authors.initials: S
authors.lastname: Ray
authors.forename: Markus
authors.initials: M
authors.lastname: Britschgi
authors.forename: Charles
authors.initials: C
authors.lastname: Herbert
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Takeda-Uchimura
authors.forename: Adam
authors.initials: A
authors.lastname: Boxer
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.forename: Leah F
authors.initials: LF
authors.lastname: Friedman
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Galasko
authors.forename: Marek
authors.initials: M
authors.lastname: Jutel
authors.forename: Anna
authors.initials: A
authors.lastname: Karydas
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Kaye
authors.forename: Jerzy
authors.initials: J
authors.lastname: Leszek
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.forename: Lennart
authors.initials: L
authors.lastname: Minthon
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Quinn
authors.forename: Gil D
authors.initials: GD
authors.lastname: Rabinovici
authors.forename: William H
authors.initials: WH
authors.lastname: Robinson
authors.forename: Marwan N
authors.initials: MN
authors.lastname: Sabbagh
authors.forename: Yuen T
authors.initials: YT
authors.lastname: So
authors.forename: D Larry
authors.initials: DL
authors.lastname: Sparks
authors.forename: Massimo
authors.initials: M
authors.lastname: Tabaton
authors.forename: Jared
authors.initials: J
authors.lastname: Tinklenberg
authors.forename: Jerome A
authors.initials: JA
authors.lastname: Yesavage
authors.forename: Robert
authors.initials: R
authors.lastname: Tibshirani
authors.forename: Tony
authors.initials: T
authors.lastname: Wyss-Coray
mesh_terms: D000544:Alzheimer Disease / Q000097:blood / Q000145:classification* / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D003072:Cognition Disorders / Q000097:blood / Q000145:classification / Q000175:diagnosis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D010641:Phenotype; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins