title: Imprint cytology improves accuracy of computed tomography-guided percutaneous transthoracic needle biopsy.
abstract: The aim of the present study was to investigate whether imprint cytology can improve the diagnostic accuracy of computed tomography-guided transthoracic core biopsy. Between October 1997 and June 2004, thoracic lesions in 622 patients underwent biopsy using 19-gauge coaxial guiding needles and 20-gauge biopsy needles under computed tomography guidance. Touch imprint cytology and histopathology were performed for all biopsy specimens. Of these lesions, 431 (74.1%) were diagnosed as malignant, 151 (25.9%) as benign and 40 (6%) as nondiagnostic. Imprint cytology plus histology shows an improved diagnostic accuracy of 96.4% compared with that of imprint cytology alone (92.3%) or histopathology alone (93.0%). Procedure-related complications requiring further treatment occurred in eight (1.4%) patients. In conclusion, imprint cytology combined with histopathology can improve the diagnostic accuracy of computed tomography-guided transthoracic needle biopsy.
authors.affiliation: Dept of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Chang
authors.forename: C-J
authors.initials: CJ
authors.lastname: Yu
authors.forename: W-J
authors.initials: WJ
authors.lastname: Lee
authors.forename: S-H
authors.initials: SH
authors.lastname: Kuo
authors.forename: C-H
authors.initials: CH
authors.lastname: Hsiao
authors.forename: I-S
authors.initials: IS
authors.lastname: Jan
authors.forename: F-C
authors.initials: FC
authors.lastname: Hu
authors.forename: H-M
authors.initials: HM
authors.lastname: Liu
authors.forename: W-K
authors.initials: WK
authors.lastname: Chan
authors.forename: P-C
authors.initials: PC
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001707:Biopsy, Needle; D003584:Cytological Techniques; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*