Prognostic factors in typhoid ileal perforation: a prospective study of 53 cases.
BACKGROUND
Typhoid ileal perforation remains a serious complication of typhoid enteritis with high morbidity and mortality in many tropical countries.


OBJECTIVE
To determine the prognostic factors in typhoid perforation in Kano, Nigeria.


METHODS
Fifty-three consecutive patients with typhoid perforation managed surgically were prospectively studied at the general surgical unit of Aminu Kano Teaching Hospital Kano, from March 2004 to February 2006.


RESULTS
There were 26 (49.1%) males and 27 (50.9%) females, with age range of 2-55 years and a mean +/- SD of 12.2 +/- 10.2 years. The morbidity was 49.1% and the most common postoperative complications included wound infection, wound dehiscence, burst abdomen, residual intra-abdominal abscesses and enterocutaneous fistula. Mortality was 15.1% and was significantly affected by multiple perforations, severe peritoneal contamination and burst abdomen (p value <0.05, odds ratio >1). The mean duration of hospital stay for survivors was 16.1 days with a range of 8-57 days.


CONCLUSIONS
This study has attempted to determine the factors that statistically influence mortality in typhoid perforation in our environment.
Edino
Steven T
ST
Department of Surgery, Bayero University, Kano, Nigeria. steveedino@yahoo.com
Yakubu
Ahmed A
AA
Mohammed
Aminu Z
AZ
Abubakar
Isa S
IS
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004751:Enteritis / Q000209:etiology* / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000209:etiology* / Q000382:microbiology; D007416:Intestinal Perforation / Q000209:etiology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D011183:Postoperative Complications; D011379:Prognosis; D011446:Prospective Studies; D013534:Survival; D016896:Treatment Outcome; D014435:Typhoid Fever / Q000150:complications* / Q000401:mortality / Q000601:surgery