title: Cost-effectiveness of live-attenuated influenza vaccine, trivalent in preventing influenza in young children attending day-care centres.
abstract: Vaccinating children at day-care may be a cost-effective approach for improving influenza immunization rates in this high-risk group. This study uses influenza attack-rate data from a randomized, blinded, placebo-controlled clinical trial of live-attenuated influenza vaccine, trivalent in day-care centres from two consecutive influenza seasons, one with a moderate attack rate (H1N1 dominant) and one with a high attack rate (H3N2 dominant). Costs were measured in US dollars. In the moderate attack-rate season (vaccinated, 2.2%; placebo, 13.4%), vaccination saved US$ 5.47 per child in societal costs. In the high attack-rate season (vaccinated, 4.7%; placebo, 32.1%), vaccination led to a societal costs savings of US$ 144.44 per child.
authors.affiliation: RTI Health Solutions, Williams House, Manchester Science Park, Lloyd Street North, Manchester M15 6SE, United Kingdom. hibbert@rti.org
authors.forename: Clare L
authors.initials: CL
authors.lastname: Hibbert
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Piedra
authors.forename: Kimmie K
authors.initials: KK
authors.lastname: McLaurin
authors.forename: Timo
authors.initials: T
authors.lastname: Vesikari
authors.forename: Josephine
authors.initials: J
authors.lastname: Mauskopf
authors.forename: Parthiv J
authors.initials: PJ
authors.lastname: Mahadevia
mesh_terms: D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D003695:Delivery of Health Care; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000191:economics* / Q000276:immunology*; D007251:Influenza, Human / Q000191:economics / Q000276:immunology / Q000517:prevention & control*; D012578:Schools, Nursery; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014613:Vaccines, Attenuated / Q000191:economics / Q000276:immunology*
chemical_list: D007252:Influenza Vaccines; D014613:Vaccines, Attenuated