Betraying the parasite's redox system: diaryl sulfide-based inhibitors of trypanothione reductase: subversive substrates and antitrypanosomal properties.
Stump
Bernhard
B
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg, HCI, 8093 Zürich, Switzerland.
Kaiser
Marcel
M
Brun
Reto
R
Krauth-Siegel
R Luise
RL
Diederich
François
F
D000818:Animals; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology*; D007891:Leishmania / Q000201:enzymology*; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010084:Oxidation-Reduction; D013379:Substrate Specificity; D013440:Sulfides / Q000493:pharmacokinetics / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D014345:Trypanosoma / Q000201:enzymology*
D004791:Enzyme Inhibitors; D013440:Sulfides; D014344:Trypanocidal Agents; D009247:NADH, NADPH Oxidoreductases; C049608:trypanothione reductase