Concise total synthesis of (-)-spongotine A.
The first asymmetric total synthesis of spongotine A is described. The oxidative synthesis of the imidazoline/ketone unit from keto aldehyde and diamine is a key step in this synthesis. The absolute stereochemistry of the asymmetric center of natural spongotine A is revealed as the (S)-configuration.
Murai
Kenichi
K
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-Oka, Suita, Osaka, Japan.
Morishita
Maiko
M
Nakatani
Ryo
R
Kubo
Ozora
O
Fujioka
Hiromichi
H
Kita
Yasuyuki
Y
D020650:Combinatorial Chemistry Techniques; D048288:Imidazolines / Q000138:chemical synthesis* / Q000737:chemistry; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D048288:Imidazolines; D026121:Indole Alkaloids; C525418:spongotine A