title: Statistical modeling of ultrastructural features of murine dermal collagen under chronic low-dose whole body X-irradiation.
abstract: The present study investigated the changes in ultrastructural features of dermal collagen fibrils of mice following exposure to different cumulative chronic low-dose X-irradiation through digital image analysis-based statistical modeling. Pubertal mice were X-irradiated and dorsal skin biopsies were collected and processed for transmission electron microscopic (TEM) analysis. TEM features of collagen fibrils showed alteration in the cross-sectional area, population density and in the axial periodic pattern of light and dark bands. The mathematical analysis of histogram data from TEM images revealed some adaptive behavior in collagen structures of the X-irradiated group. This finding indicated that exposure to chronic low-dose X-radiation induced an altered steady state with adaptive variation in dermal collagen fibrils in irradiated mice.
authors.affiliation: Department of Radiology (Diag.), Medical College Hospital, 88 College St., Kolkata 700073, India.
authors.forename: Jyotirmoy
authors.initials: J
authors.lastname: Chatterjee
authors.forename: Anirban
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Kanchan
authors.initials: K
authors.lastname: Mukherjee
authors.forename: Pranab K
authors.initials: PK
authors.lastname: Dutta
authors.forename: Keya
authors.initials: K
authors.lastname: Chaudhuri
mesh_terms: D000818:Animals; D003094:Collagen / Q000528:radiation effects* / Q000648:ultrastructure*; D051379:Mice; D008815:Mice, Inbred Strains; D046529:Microscopy, Electron, Transmission; D008954:Models, Biological; D012867:Skin / Q000528:radiation effects* / Q000648:ultrastructure*; D014916:Whole-Body Irradiation; D014965:X-Rays
chemical_list: D003094:Collagen