IL-15 and psoriasis: another genetic link to Th17?
Interleukin-15 (IL-15) is a pro-inflammatory cytokine expressed in several inflammatory disorders. Zhang et al. (2007, this issue) report a significant genetic association between IL-15 and psoriasis, which may involve increased stability of IL-15 mRNA. Among its several activities, IL-15 stimulates the expression of IL-17 by T-cells. Together with recent genetic and therapeutic evidence implicating IL-23, these findings suggest a genetic basis for Th17-mediated inflammation in psoriasis.
Elder
James T
JT
Department of Dermatology, University of Michigan, and Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan 48109-0932, USA. jelder@umich.edu
D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism; D019409:Interleukin-15 / Q000235:genetics / Q000378:metabolism*; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D053759:Interleukin-23 / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011565:Psoriasis / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism* / Q000473:pathology
D019409:Interleukin-15; D020381:Interleukin-17; D053759:Interleukin-23; D012333:RNA, Messenger