title: Therapeutic trial of granulocyte-colony stimulating factor for dilated cardiomyopathy in three dogs.
abstract: Three dogs were presented to us for evaluation of cardiac problems. Electrocardiographic recordings revealed severe tachyarrhythmia and atrial fibrillation with ventricular tachycardia in 2 of the 3 dogs. The echocardiographic findings of the 3 dogs revealed markedly decreased fractional shortening and a marked increase in E-point septal separation. Based on the results of electrocardiographic and echocardiographic evaluation, the 3 dogs were diagnosed as dilated cardiomyopathy (DCM). The dogs were treated with conventional cardiac medication, but cardiac function did not improve and the clinical signs remained. We subsequently attempted treatment with granulocyte-colony stimulating factor (G-CSF; 10 microg/kg, subcutaneously). The specific purpose of G-CSF therapy for DCM was to improve cardiac function and a significant improvement in cardiac function was confirmed. The three dogs had no treatment side effects. This case report suggests that G-CSF might have therapeutic effects for medically refractory DCM in dogs.
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
authors.forename: Chul
authors.initials: C
authors.lastname: Park
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Yoo
authors.forename: Hyo-Won
authors.initials: HW
authors.lastname: Jeon
authors.forename: Byeong-Teck
authors.initials: BT
authors.lastname: Kang
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Dong-In
authors.initials: DI
authors.lastname: Jung
authors.forename: Chae-Young
authors.initials: CY
authors.lastname: Lim
authors.forename: Hye-Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Hahm
authors.forename: Eung-Je
authors.initials: EJ
authors.lastname: Woo
authors.forename: Hee-Myung
authors.initials: HM
authors.lastname: Park
mesh_terms: D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D004562:Electrocardiography / Q000662:veterinary; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D008297:Male
chemical_list: D016179:Granulocyte Colony-Stimulating Factor