In Vitro susceptibility of methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus to a new antimicrobial, copper silicate.
The soluble copper silicate (CS) MIC of 100 strains of methicillin-resistant Staphylococcus aureus and 100 strains of methicillin-susceptible S. aureus (MSSA) was 175 mg Cu/liter. Bactericidal and postantibiotic effects (> or =1 h) were seen at 2x MIC and 4x MIC. The frequency of mutation was <10(-9), and serial passage could not extend growth beyond 1.6x MIC.
Carson
Kerry C
KC
Division of Microbiology & Infectious Diseases, PathWest Laboratory Medicine WA, Nedlands, Western Australia 6909, Australia. k-carson@cyllene.uwa.edu.au
Bartlett
Jessica G
JG
Tan
Trina-Jean
TJ
Riley
Thomas V
TV
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology*; D016106:Methicillin Resistance / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D017640:Silicates / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D017640:Silicates; C047041:copper silicate; D003300:Copper