Total brain tissue sialic acid levels due to glutathione effect in experimental epilepsy.
Epilepsy can be described as a group of neurological disorders, characterized by recurrent episodes of convulsive seizures, loss of consciousness, sensory disturbances, abnormal behavior, or all of these. Altered glutathione metabolism in association with increased oxidative stress has been implicated in the pathogenesis of many diseases such as seizures. It is therefore reasonable to propose that sialic acid levels can be affected by this pathological state or, alternately, by seizures. The present study showed that the sialic acid levels were significantly different between the experimental groups as well as in the subgroup analysis. The results suggest that glutathione may have a neuroprotective effect by decreasing sialic acid levels in mice brain.
Pence
Sadrettin
S
Department of Physiology, Faculty of Medicine University of Gaziantep, Gaziantep, Turkey. pence@gantep.edu.tr
Erkutlu
Ibrahim
I
Kurtul
Naciye
N
Bosnak
Mehmet
M
Tan
Uner
U
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003292:Convulsants / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000494:pharmacology*; D008297:Male; D051379:Mice; D019158:N-Acetylneuraminic Acid / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000008:administration & dosage; D014018:Tissue Distribution
D003292:Convulsants; D018696:Neuroprotective Agents; D005978:Glutathione; D019158:N-Acetylneuraminic Acid; D010433:Pentylenetetrazole