The bacterial metabolite 2,3-butanediol ameliorates endotoxin-induced acute lung injury in rats.
Widely identified in bacteria, yeasts and human beings, 2,3-butanediol has been studied for decades. This chemical reportedly functions as a neutralization agent to counteract lethal acidification by bacterial growth and as a signaling molecule involved in interactions among insects, and between bacteria and the plant host. While 2,3-butanediol is produced by many pathogenic bacterial species, its significance and effect on mammals remains basically uncharacterized. Herein, we show that gastric intubation of 2,3-butanediol in rats significantly ameliorates acute lung injury (ALI) and the inflammatory responses induced by the bacterial endotoxin lipopolysaccharide (LPS), with an efficacy comparable to that of the polyphenol compound resveratrol. Such effect was further demonstrated to occur via modulation of the NF-kappaB signaling pathway. These results indicate that bacterial metabolite, 2,3-butanediol has a negative regulatory effect on host innate immunity response, suggesting bacteria may use some metabolites for host immune evasion.
Hsieh
Shang-Chen
SC
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100, Taiwan, ROC.
Lu
Chia-Chen
CC
Horng
Yu-Tze
YT
Soo
Po-Chi
PC
Chang
Yung-Lin
YL
Tsai
Yu-Huan
YH
Lin
Chuan-Sheng
CS
Lai
Hsin-Chih
HC
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002072:Butylene Glycols / Q000008:administration & dosage*; D004731:Endotoxins / Q000008:administration & dosage / Q000633:toxicity*; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity*; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000473:pathology*; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D002072:Butylene Glycols; D004731:Endotoxins; D008070:Lipopolysaccharides; D016328:NF-kappa B; C026978:2,3-butylene glycol