Electrical characteristics of various submucosal injection fluids for endoscopic mucosal resection.
Submucosal fluid injection, prerequisite to endoscopic mucosal resection, necessitates detailed evaluation for proper selection. We aimed to compare height of gastric tissues after submucosal injection, and to verify electrical implications of injectants. Porcine stomach pieces were cut out, and eight solutions were used: normal saline, 0.5% sodium hyaluronate (SH), 0.25% SH, hydroxypropyl methylcellulose, 10% glycerin, fibrinogen, 1% sodium alginate (SA), and 2.5% SA. Elevated heights were measured after submucosal injection of the eight fluids, and electrical impedance was measured for fluids plus a reference solution (0.01 N KCl) with a potentiostat electroimpedance spectrometry and an insulation-tipped knife. Resistivity was calculated thereafter. Normal saline and 10% glycerin solution showed greater height diminution. Resistivity were in the range of 80-110 Omega cm, except for 309.7 Omega cm for fibrinogen. Higher resistivity may improve performance of electrosurgery, probably by strengthening impedance and heat dissipation. Further studies are required to back up this basic experiment for clinical application.
Park
Sanghoon
S
Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, 126-1, 5 ga, Anam-dong, Seongbuk-gu, Seoul, Korea.
Chun
Hoon Jai
HJ
Kim
Chul Young
CY
Kim
Ju Young
JY
Jang
Jin Su
JS
Kwon
Yong Dae
YD
Kim
Doo Rang
DR
Keum
Bora
B
Seo
Yeon Seok
YS
Kim
Yong Sik
YS
Jeen
Yoon Tae
YT
Lee
Hong Sik
HS
Um
Soon Ho
SH
Lee
Sang Woo
SW
Choi
Jae Hyun
JH
Kim
Chang Duck
CD
Ryu
Ho Sang
HS
Chang
Jong Hyeon
JH
Pak
James Jungho
JJ
D000464:Alginates / Q000008:administration & dosage / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D017097:Electric Impedance; D005340:Fibrinogen / Q000008:administration & dosage / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000601:surgery*; D005773:Gastroscopy; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000494:pharmacology; D005990:Glycerol / Q000008:administration & dosage / Q000494:pharmacology; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000494:pharmacology; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000494:pharmacology; D007267:Injections; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D012996:Solutions / Q000008:administration & dosage / Q000494:pharmacology*; D013552:Swine
D000464:Alginates; D006603:Hexuronic Acids; D012996:Solutions; D012965:Sodium Chloride; D020723:Glucuronic Acid; D005340:Fibrinogen; D006820:Hyaluronic Acid; D005990:Glycerol