title: Ultrastructural analysis of the endometrial mucosa of female patients at menopause with hormonal substitutive therapy (TSH).
abstract: The objective of the paper was to observe the ultrastructural aspects of the endometrial biopsies taken from female patients at post-menopause with substitutive hormonal therapy (TSH). Material and methods. A number of three endometrial biopsies were taken from female patients at post-menopause with TSH. The ultrastructural analysis was carried out with the help of the electronic microscope Philips ME 301 using classical electronic microscopy methods. Results and discussions. The ultrastructural analysis has highlighted the presence of cuboidal and columnar epithelial cells, with basally situated nuclei, well represented cellular organelles, some cells having at the apical pole microvilli. At the electronic microscope, three types of epithelial cells are described, at the level of the endometrial mucosa of the woman who is in a fertile period: secretory cells (cells with an average electronic density with microvilli on the luminal surface), ciliated cells and clear cells (cells with a low electronic density). These cells have certain ultrastructural characteristics and of receptivity towards the steroid hormones. The stroma is axial with elongated cells with oval nuclei, with nucleoli and with smooth or undulated membrane. Conclusions. The ultrastructural aspects suggest the presence at endometrial level of epithelial active glandular cells, secretory cells and stromal active cells at female patients at post-menopause with TSH.
authors.affiliation: Department of Histopathology and Immunohistochemistry, Victor Babes National Institute for Research and Development in Pathology and Biomedical Sciences, Bucharest, Romania. danaterzea@gmail.com
authors.forename: Dana
authors.initials: D
authors.lastname: Terzea
authors.forename: Mihaela
authors.initials: M
authors.lastname: Gherghiceanu
authors.forename: Cristina
authors.initials: C
authors.lastname: Iosif
authors.forename: Florina
authors.initials: F
authors.lastname: Vasilescu
authors.forename: F
authors.initials: F
authors.lastname: Andrei
authors.forename: Camelia
authors.initials: C
authors.lastname: Dobrea
authors.forename: Alina
authors.initials: A
authors.lastname: Nicolae
authors.forename: Alina
authors.initials: A
authors.lastname: Georgescu
authors.forename: M
authors.initials: M
authors.lastname: Ceauşu
authors.forename: Ariana
authors.initials: A
authors.lastname: Vişan
authors.forename: Mihaela
authors.initials: M
authors.lastname: Mihai
authors.forename: Carmen
authors.initials: C
authors.lastname: Ardeleanu
mesh_terms: D004717:Endometrium / Q000187:drug effects* / Q000648:ultrastructure*; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects* / Q000648:ultrastructure*; D011374:Progesterone / Q000627:therapeutic use; D045167:Progesterone Congeners / Q000627:therapeutic use
chemical_list: D004967:Estrogens; D045167:Progesterone Congeners; D011374:Progesterone