title: Asymmetric 1,3-dipolar cycloadditions of nitrones and methacrolein catalyzed by chiral bis-titanium lewis acid: a dramatic effect of N-substituent on nitrone.
abstract: Highly stereoselective 1,3-dipolar cycloadditions of methacrolein and nitrones could be realized by the use of bis-titanium chiral Lewis acid catalyst. Key to the success is the introduction of bulky N-substituent on nitrone to attenuate the undesired Lewis acid-nitrone complexation.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Masato
authors.initials: M
authors.lastname: Omote
authors.forename: Taichi
authors.initials: T
authors.lastname: Kano
authors.forename: Keiji
authors.initials: K
authors.lastname: Maruoka