title: Highly efficient asymmetric reduction of arylpropionic aldehydes by horse liver alcohol dehydrogenase through dynamic kinetic resolution.
abstract: The enantioselective synthesis of (2S)-2-phenylpropanol and (2S)-2-(4-iso-butylphenyl)propanol ((S)-Ibuprofenol) has been achieved by means of Horse Liver Alcohol Dehydrogenase (HLADH) in buffered aqueous solution or buffered organic solvent mixtures; under the reaction conditions, a dynamic kinetic resolution (DKR) process was realized with good reaction yields and enantiomeric ratios.
authors.affiliation: Department of Chemistry G. Ciamician, Alma Mater Studiorum University of Bologna, Via Selmi 2, 40126, Bologna, Italy. daria.giacomini@unibo.it
authors.forename: Daria
authors.initials: D
authors.lastname: Giacomini
authors.forename: Paola
authors.initials: P
authors.lastname: Galletti
authors.forename: Arianna
authors.initials: A
authors.lastname: Quintavalla
authors.forename: Gabriele
authors.initials: G
authors.lastname: Gucciardo
authors.forename: Francesca
authors.initials: F
authors.lastname: Paradisi
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000447:Aldehydes / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D006736:Horses; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D020005:Propanols / Q000737:chemistry; D011422:Propionates / Q000737:chemistry*; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D020005:Propanols; D011422:Propionates; D012997:Solvents; C439395:1-phenylpropanol; D000426:Alcohol Dehydrogenase; C029658:propionic acid