Origin of renal proximal tubular injuries by Fe(III)-nta chelate.
Interaction between apo-transferrin and several iron(III) chelates has been investigated in terms of the capillary electrophoresis method. Based on the results, it has been clarified that (i) a binuclear iron(III) unit with an oxo-bridge is necessary for the facile transfer of an iron atom from the iron(III) chelate to apo-transferrin, and (ii) the renal proximal tubular injuries by Fe(III)-nitrilotriacetate (Fe-nta) should be due to the unique binuclear structure of this complex, which gives a peroxide adduct of the binuclear Fe-nta in the presence of glutathione cycle and oxygen.
Nishida
Yuzo
Y
Department of Chemistry, Faculty of Science, Yamagata University, Yamagata 990-8560, Japan. yuzo@sci.kj.yamagata-u.ac.jp
Ito
Yuuta
Y
Satoh
Takahiro
T
D000818:Animals; D001059:Apoproteins / Q000302:isolation & purification / Q000494:pharmacology*; D019075:Electrophoresis, Capillary; D005029:Ethylenediamines / Q000494:pharmacology; D006801:Humans; D007502:Iron Chelating Agents / Q000302:isolation & purification / Q000633:toxicity*; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000293:injuries*; D051381:Rats; D014168:Transferrin / Q000302:isolation & purification / Q000494:pharmacology*
D001059:Apoproteins; D005029:Ethylenediamines; D007502:Iron Chelating Agents; D014168:Transferrin; C028284:apotransferrin; C110714:holotransferrin; C031234:ethylenediamine