Formulating poly(lactide-co-glycolide) particles for plasmid DNA delivery.
Biodegradable poly(lactide-co-glycolide) (PLGA) particles have shown significant potential for sustained and targeted delivery of several pharmaceutical agents, including plasmid DNA (pDNA). Here, we survey current approaches to PLGA particle preparation for pDNA delivery and discuss recent progress on optimizing formulation development.
Abbas
Aiman O
AO
Division of Pharmaceutics, College of Pharmacy, University of Iowa, S228 Pharmacy Building, 115 S Grand Avenue, Iowa City, Iowa 52242, USA.
Donovan
Maureen D
MD
Salem
Aliasger K
AK
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004247:DNA / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry*; D018014:Gene Transfer Techniques; D006801:Humans; D010957:Plasmids / Q000008:administration & dosage*; D011098:Polyglactin 910 / Q000737:chemistry*
D001672:Biocompatible Materials; D004337:Drug Carriers; D011098:Polyglactin 910; D004247:DNA