[Neurotrophic control in the development and function of two endocrine organs: the ovary and the pancreas].
Neurotrophins (NTs) are important for the survival, differentiation and function of sympathetic and sensorial neurons of central and peripheral nervous system. However, similar functions have been described of NTs in non-neural organs. Nerve Growth factor (NGF) participates in the foliculogenesis and ovulation in the ovary, as well as in the islet morphogenesis and insulin secretion of the pancreatic beta cell. The NTs act by binding to two distinct classes of transmembranal receptors: p75 and Trks. Both receptor types lead to activation of intracellular signaling cascades that end with cell survival or apoptosis. In this review different actions of the NTs in the ovarian and the pancreas are described.
Cabrera-Vásquez
Siraam
S
Departamento de Biofísica, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, DF. scabrera@ifc.unam.mx
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000502:physiology*; D009928:Organ Specificity; D006080:Ovarian Follicle / Q000502:physiology; D010053:Ovary / Q000254:growth & development / Q000502:physiology*; D010060:Ovulation / Q000502:physiology; D010179:Pancreas / Q000254:growth & development / Q000502:physiology*; D051381:Rats; D017475:Receptors, Nerve Growth Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D007328:Insulin; D009414:Nerve Growth Factors; D017475:Receptors, Nerve Growth Factor