title: The monoamine oxidase B gene exhibits significant association to ADHD.
abstract: Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition with strong genetic basis. Recent work in China indicated that ADHD may be linked to Xp1-2 in the Han Chinese population. The gene encoding monoamine oxidase B (MAOB), the main enzyme degrading dopamine in the human brain, is located in this region. The current study sequenced the exons and the 5' and 3' flanking regions of the MAOB gene and found four common variants including 2276C>T and 2327C>T in exon 15, rs1799836 in intron 13 and rs1040399 in 3'-UTR. We assessed the association of these variants with ADHD in 548 trios collected from 468 males and 80 females probands. TDT analysis showed that alleles of each polymorphism were preferentially transmitted to probands (rs1799836, P = 3.28E-15; rs1040399, P = 1.87E-6; 2276T>C or 2327T>C, P = 2.20E-6) and haplotype-based TDT analyses also found distorted transmission. In conclusion, this study provides the strongest evidence for the involvement of MAOB gene in the etiology of ADHD to date, at least in Han Chinese population.
authors.affiliation: Institute of Mental Health, Peking University (Peking University sixth hospital), China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
authors.forename: Songnian
authors.initials: S
authors.lastname: Hu
authors.forename: Rulun
authors.initials: R
authors.lastname: Zhou
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Yu
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Lili
authors.initials: L
authors.lastname: Guan
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D001483:Base Sequence; D002648:Child; D017931:DNA Primers; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006239:Haplotypes; D006801:Humans; D007438:Introns; D015810:Linkage Disequilibrium; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*
chemical_list: D017931:DNA Primers; D008995:Monoamine Oxidase