Bare rudiments of notch signaling: how receptor levels are regulated.
The Notch signaling pathway, a prototype for high-fidelity intercellular signaling mechanisms, regulates cell fate and other fundamental processes. Notch receptors are activated by transmembrane ligands present on neighboring cells through ligand-dependent proteolysis. This liberates the receptor intracellular domain, creating a transcriptional coactivator. Although tremendous progress towards elucidating the Notch activation mechanism and Notch-dependent processes has been reported, perhaps the most fundamental issue of Notch signaling is still poorly understood -- how cell-type-specific Notch-receptor expression patterns are established and regulated. This is especially true for the four mammalian Notch receptors (Notch1-4), which exhibit unique and overlapping expression patterns. However, recent studies have demonstrated the transcriptional control of Notch receptor levels as an essential determinant of Notch signaling.
Wu
Jing
J
University of Wisconsin School of Medicine, Department of Pharmacology, 385 Medical Sciences Center, Madison, WI 53706, USA.
Bresnick
Emery H
EH
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008024:Ligands; D008322:Mammals; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000378:metabolism; D011485:Protein Binding; D051880:Receptors, Notch / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D051880:Receptors, Notch; D010447:Peptide Hydrolases